LOCUS 003_TF8A_auf_Barbe 4001902 bp DNA circular CON 12-JAN-2021 DEFINITION Bacillus subtilis subsp. subtilis str. 168 complete genome. ACCESSION NC_000964 DBLINK BioProject: PRJNA76 BioSample: SAMEA3138188 KEYWORDS RefSeq; complete genome. SOURCE Bacillus subtilis subsp. subtilis str. 168 ORGANISM Bacillus subtilis subsp. subtilis str. 168 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. REFERENCE 1 AUTHORS Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C., Sekowska,A. and Vallenet,D. TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement JOURNAL Microb Biotechnol 11 (1), 3-17 (2018) PUBMED 29280348 REFERENCE 2 (bases 1 to 4215606) AUTHORS Belda,E., Sekowska,A., Le, Fevre,F., Morgat,A., Mornico,D., Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A. TITLE An updated metabolic view of the Bacillus subtilis 168 genome JOURNAL Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013) PUBMED 23429746 REFERENCE 3 (bases 1 to 4215606) AUTHORS Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G., Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and Danchin,A. TITLE From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later JOURNAL Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009) PUBMED 19383706 REFERENCE 4 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G., Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S., Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M., Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A., Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M., Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H., Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and Danchin,A. TITLE The complete genome sequence of the gram-positive bacterium Bacillus subtilis JOURNAL Nature 390 (6657), 249-256 (1997) PUBMED 9384377 REFERENCE 5 (bases 1 to 4215606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (17-SEP-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM AMAbiotics and Genoscope TITLE Direct Submission JOURNAL Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA (Commissariat a l'energie atomique et aux energies alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr) REFERENCE 7 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM Institut Pasteur and Genoscope TITLE Direct Submission JOURNAL Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr) REFERENCE 8 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail: moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33 (0)1 45 68 89 48 COMMENT ##gff-version-START## gff-version :: 3 ##gff-version-END## FEATURES Location/Qualifiers S_feature 1..148 /Source="Nicolas_S_feature" /locus_tag="new_1_148" /HighExp="T0.30H, C30, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, S2, T-1.10H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1" S_feature complement(24..297) /Source="Nicolas_S_feature" /locus_tag="new_24_297_c" /HighExp="S8, C30, Etha, S3, S7, S4, Cold, BT, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.178448" /TUshortSig="SigK, SigEF" /TUshortPSig="0.621, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S2" promotor_-35 120..124 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-35" promotor_-10 140..159 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-10" S_feature 150..409 /Source="Nicolas_S_feature" /locus_tag="new_150_409" /HighExp="Heat, G180, LPhT, G150, dia15, Oxctl, S1, G135, LBGstat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S3" upshifts 150 /Source="Nicolas_upshifts" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" promotor_-10 complement(285..304) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(297) /Source="Nicolas_upshifts" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" S_feature complement(299..1067) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" promotor_-35 complement(318..326) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-35" CDS 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" gene 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" promotor_-10 complement(1040..1058) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" promotor_-35 complement(1074..1079) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751..1938 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" gene 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" downshifts 3059 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" promotor_-35 3140..3144 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161..3180 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3169 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" gene 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" CDS 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" gene 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" misc_feature 3635..3654 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3653 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" gene 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" CDS 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" gene 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" promotor_-10 complement(6412..6430) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6414) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(6446..6451) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6784..6993 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" gene 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" promotor_-35 9373..9376 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9374 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9393..9410 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9440 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" promotor_-35 9504..9510 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9524..9543 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9529..9614 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9529 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" promotor_-35 9600..9607 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9616 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9622..9641 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" tRNA 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" tRNA 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" rRNA 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" rRNA 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" S_feature 14811..15868 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" gene complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" promotor_-35 15847..15854 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15869..15888 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15870 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" upshifts complement(15875) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" promotor_-10 complement(15884..15895) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15909..15915) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" gene 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" downshifts complement(15919) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(15945..16045) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15985) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(17238..17833) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 17369 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" promotor_-35 17427..17431 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17447..17466 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17453..17533 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17453 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" gene 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" promotor_-10 complement(17822..17840) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17833) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" promotor_-35 complement(17855..17861) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18747 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" S_feature 18866..18974 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18944..18947 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18962..18981 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18976..19061 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18976 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" gene 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" S_feature complement(19194..19923) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19911..19929) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19923) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" promotor_-35 complement(19945..19950) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" gene 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" misc_RNA 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" downshifts 20788 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" CDS 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" gene 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" downshifts 22135 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" promotor_-35 22246..22253 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 22268..22287 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 22268 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" tRNA 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" downshifts 22407 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" S_feature 22452..22529 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " gene complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" promotor_-35 22515..22521 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22520) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" S_feature 22531..23167 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22531 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 22535..22546 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" gene complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" promotor_-10 complement(23810..23829) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23828) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" promotor_-35 complement(23845..23849) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" gene complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" downshifts complement(23905) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(25182..25200) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25203) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25216..25221) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" gene complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" promotor_-35 25632..25636 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25651..25670 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25655..25851 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25657 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" promotor_-10 complement(25791..25809) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25810) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25824..25830) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" gene 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" promotor_-35 26341..26347 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" gene 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" S_feature 26383..26532 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 26383 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" S_feature 26636..26731 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26688 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" promotor_-35 26752..26755 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26770..26789 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26779 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" gene 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" promotor_-35 28346..28353 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 28368..28387 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 28383 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" gene 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" CDS 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" gene 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" CDS 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" gene 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" promotor_-35 29708..29713 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29725 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" promotor_-10 29729..29747 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" gene 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" promotor_-35 30048..30055 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 30069..30088 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 30076..30278 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 30076 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" rRNA 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" tRNA 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" tRNA 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" rRNA 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" S_feature 35104..35236 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" S_feature 35356..35458 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35419..35427 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35441..35460 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35460 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" CDS 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" gene 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" downshifts 35709 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" promotor_-35 35770..35779 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35791..35806 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35797 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" gene 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" CDS 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" gene 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" S_feature 37639..37719 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" gene 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" promotor_-35 39082..39088 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 39103..39121 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 39112 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" CDS 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" gene 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" promotor_-35 39792..39799 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39812..39831 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39823 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" gene 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" CDS 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" gene 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" CDS 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" gene 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" CDS 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " gene 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" CDS 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" gene 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" CDS 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" gene 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" CDS 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" gene 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" CDS 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" gene 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" downshifts 44772 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" CDS complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" gene complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" downshifts complement(44850) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" downshifts 45169 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" promotor_-10 complement(45205..45224) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45222) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" S_feature complement(45224..45399) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(45238..45245) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(45395..45414) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(45399) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" promotor_-35 complement(45428..45435) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45499..45503 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45518..45537 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45524..45632 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45524 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" CDS 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" gene 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" promotor_-10 complement(46381..46400) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(46389) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(46416..46420) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47611 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" S_feature complement(47673..50019) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" gene 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" S_feature 48474..48554 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48531..48536 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48552..48570 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48556 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-35 48581..48584 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48599..48618 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48616 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" CDS 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" gene 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" promotor_-35 48649..48656 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48667 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 48671..48690 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49903 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" promotor_-35 49965..49969 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49985..50004 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49987..50086 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49987 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 complement(50011..50026) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(50027) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" promotor_-35 complement(50038..50047) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 50083..50099 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" gene 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" upshifts 50097 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" CDS 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" gene 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" downshifts 51483 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" promotor_-35 51533..51542 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51556..51575 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51558..51679 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51558 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" CDS 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" gene 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" downshifts 52539 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" S_feature 52649..52719 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52710..52717 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52721 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" promotor_-10 52731..52750 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52740..52754) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52747) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(52763..52767) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" gene 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" downshifts 52935 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" downshifts 53022 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" promotor_-35 53088..53094 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 53108..53119 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 53111..53182 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 53111 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" CDS 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" gene 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" downshifts 53353 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" S_feature complement(53363..55717) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53446..53450 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53466..53485 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53469 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" CDS 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" gene 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" CDS 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" gene 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" CDS 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" gene 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" downshifts 55662 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" promotor_-10 complement(55706..55724) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55707..55815 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55718) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" promotor_-35 complement(55740..55745) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55795..55803 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55814..55832 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55817 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" CDS 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" gene 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" downshifts 56148 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" S_feature 56193..56304 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 56286..56290 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 56306..56325 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 56306 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" gene 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" downshifts complement(57697) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" CDS 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" gene 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" promotor_-35 58711..58717 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58730 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" promotor_-10 58732..58750 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" gene 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" downshifts 59381 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" CDS 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" gene 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" misc_feature 59683..59686 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59689 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" gene 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" S_feature 60361..60429 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" gene 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" promotor_-35 63981..63987 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 64001..64098 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 64001..64012 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 64001 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" CDS 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" gene 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" downshifts 64639 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" misc_feature 64735..64754 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64746 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" CDS 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" gene 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" promotor_-35 66286..66293 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 66308..66327 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 66322 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" CDS 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" gene 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" promotor_-35 67046..67053 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 67067..67085 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 67081 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" promotor_no_box complement(67469..67569) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67509) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" gene 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" promotor_-35 68142..68147 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68163..68181 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68181 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" downshifts complement(68213) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" CDS 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" gene 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" CDS 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" gene 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" promotor_-35 69020..69029 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69042..69057 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69044 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" promotor_-35 69076..69084 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69095..69113 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69105 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" CDS 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" gene 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" CDS 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" gene 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" downshifts 70006 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" promotor_-35 70120..70127 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 70141..70160 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 70156 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" tRNA 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" tRNA 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" downshifts 70337 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" S_feature 70382..70493 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70489..70508 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70495 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" CDS 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" gene 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" downshifts 70579 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" S_feature complement(71190..71799) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(71216) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" promotor_-10 complement(71772..71790) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71798) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" promotor_-35 complement(71806..71811) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 72003..72009 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72024..72042 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72031 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" promotor_-35 73041..73044 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 73062..73079 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 73065 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" CDS 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" gene 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" CDS 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" gene 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" promotor_-35 74357..74363 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 74379..74397 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 74385 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" promotor_-35 74855..74862 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74876..74895 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74886 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" gene 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" promotor_-35 75724..75731 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75746..75765 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75749 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" downshifts complement(76342) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" CDS 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" gene 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" upshifts complement(76749) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(76751..76755) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76773..76776) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76887..76983 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" gene 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" downshifts 78895 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" misc_feature complement(78934..78938) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78940..79025 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78942) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 79002..79009 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 79023..79042 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 79027..79091 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 79027 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" gene 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" CDS 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" gene 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" CDS 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" gene 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" promotor_-35 81425..81430 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81447..81465 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81448 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 81694..81701 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81716..81735 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81723 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" gene 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" downshifts 82690 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" promotor_-35 82744..82752 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82766..82774 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82768 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 82796..82799 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82814..82833 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82824 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" gene 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" promotor_-35 83666..83668 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83686..83704 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83692 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 84033..84040 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 84053..84072 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 84066 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" gene 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" CDS 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" gene 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" CDS 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" gene 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" CDS 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" gene 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" CDS 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" gene 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" CDS 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" gene 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" CDS 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " gene 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" S_feature complement(88050..89566) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88636..88726 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" gene 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" promotor_-10 complement(89550..89568) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89566) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" promotor_-35 complement(89584..89589) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 90207 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" promotor_-35 90302..90309 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 90318..90535 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 90318 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" promotor_-10 90323..90342 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(90368) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" rRNA 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" rRNA 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" rRNA 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" tRNA 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" tRNA 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" tRNA 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" tRNA 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" tRNA 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" tRNA 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" tRNA 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" tRNA 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" tRNA 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" rRNA 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" rRNA 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" rRNA 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" S_feature 101212..101289 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 101259..101262 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101278..101297 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101291 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-35 101325..101331 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 101345..101364 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 101356 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" promotor_-35 101371..101378 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101392..101411 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101404 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" gene 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" misc_feature complement(101560..101564) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101566) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" gene 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" CDS 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" gene 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" CDS 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" gene 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" downshifts 105999 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" CDS 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" gene 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" promotor_-35 106551..106560 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106573..106588 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106576 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" gene 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" S_feature 108559..108673 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" gene 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" downshifts complement(109596) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" CDS 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" gene 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" CDS 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" gene 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" promotor_-35 110960..110967 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110981..111000 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110994 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" gene 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" promotor_-35 111976..111985 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111999..112018 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111999 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" S_feature 112499..112799 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " gene 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" CDS 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" gene 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" CDS 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" gene 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" CDS 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" gene 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" CDS 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" gene 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" promotor_-35 116536..116543 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116558..116577 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116560 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" gene 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" downshifts complement(117054) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" S_feature 117257..117348 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" gene 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" CDS 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" gene 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" S_feature 117712..117889 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117883) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" CDS 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" gene 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" upshifts complement(117978) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(117981..117985) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(118000..118005) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118434..118441 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118452..118590 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118452 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 118455..118474 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" gene 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" S_feature 119017..119110 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" gene 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" downshifts complement(119783) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" misc_RNA 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" gene 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" upshifts complement(119871) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(119874..119878) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119927 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" CDS 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" gene 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" CDS 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" gene 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" downshifts 120894 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" downshifts 120967 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" CDS 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" gene 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" promotor_-35 121668..121672 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121686..121918 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121686 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 121688..121707 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" gene 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" promotor_-10 complement(123504..123523) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123507) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(123537..123546) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(124375..124379) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(124380) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(124394..124400) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" gene 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" downshifts complement(128626) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" upshifts complement(128780) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(128798..128799) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(129110) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" S_feature 129162..129283 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 129265..129272 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 129285 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 129286..129305 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(129303..129307) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(129306) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" gene 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" S_feature 129589..129701 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" gene 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" CDS 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" gene 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" CDS 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" gene 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" S_feature 132763..132881 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" gene 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" downshifts 134067 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" misc_feature complement(134098..134101) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(134102) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 134128..134147 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 134136 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" gene 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" promotor_-35 135134..135141 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 135155..135174 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 135170..135363 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 135170 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" CDS 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" gene 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" CDS 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" gene 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" CDS 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" gene 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" CDS 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" gene 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" CDS 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" gene 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" downshifts complement(137447) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" CDS 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" gene 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" CDS 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" gene 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" CDS 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" gene 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" downshifts complement(138855) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(138936..138940) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138943) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(138957..138959) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" gene 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" CDS 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" gene 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" CDS 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" gene 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" CDS 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" gene 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" CDS 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" gene 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" CDS 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" gene 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" CDS 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" gene 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" CDS 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" gene 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" downshifts complement(142375) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" CDS 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" gene 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" CDS 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" gene 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" CDS 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" gene 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" CDS 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" gene 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" CDS 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" gene 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" CDS 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" gene 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" CDS 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " gene 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" CDS 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" gene 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" CDS 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" gene 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" CDS 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" gene 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" CDS 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" gene 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" CDS 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" gene 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" CDS 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" gene 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" S_feature 148755..148930 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" gene 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" CDS 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" gene 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" downshifts 150317 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" S_feature 150362..150442 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" gene 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" CDS 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" gene 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" CDS 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" gene 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" CDS 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" gene 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" S_feature complement(153039..153507) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 153172..153177 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153192..153209 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153211 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" promotor_-10 complement(153507..153526) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153529) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" promotor_-35 complement(153539..153548) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153700..153706 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153721..153740 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153725 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" misc_RNA 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" gene 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" CDS 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" gene 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" CDS 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" gene 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" downshifts 154667 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" promotor_-35 154809..154816 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154830..154849 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154838..155119 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154838 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" misc_feature 155118..155137 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 155121 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" CDS 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" gene 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" downshifts 155914 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" promotor_-35 156053..156059 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156074..156085 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156081 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" CDS 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" gene 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" promotor_-35 156552..156557 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156573..156591 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156574 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" CDS 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" gene 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" upshifts 157370 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" misc_feature 157373..157392 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" gene 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" S_feature complement(158050..158514) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158465 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" S_feature 158510..159181 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" gene complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" promotor_-10 complement(159104..159115) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(159116) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" promotor_-35 complement(159129..159135) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(159149..159778) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" gene 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" S_feature 159779..160673 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" gene complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" promotor_-10 complement(160574..160592) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160594) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" promotor_-35 complement(160608..160613) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160651..160658 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160673..160692 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160675..160892 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160675 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" rRNA 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" rRNA 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" rRNA 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" tRNA 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" tRNA 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" tRNA 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" tRNA 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" tRNA 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" tRNA 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" rRNA 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" rRNA 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" rRNA 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" rRNA 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" rRNA 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" rRNA 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" S_feature 176316..176924 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176892..176896 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176912..176931 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176926..177082 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176926 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" CDS 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" gene 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" downshifts 178508 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" promotor_-35 178562..178567 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178580..178599 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178598 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" CDS 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" gene 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" downshifts 179566 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" CDS complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" gene complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" downshifts complement(179619) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" CDS complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" gene complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" CDS complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" gene complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" CDS complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" gene complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" promotor_-35 182683..182689 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182704..182722 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182713 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(183354..183373) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(183361) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" CDS complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" gene complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" promotor_-10 complement(185044..185063) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(185056) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" promotor_-35 complement(185078..185085) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(185165) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" CDS complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" gene complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" downshifts complement(185215) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" CDS complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" gene complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" CDS complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" gene complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" CDS complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" gene complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" CDS complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" gene complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" CDS complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" gene complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" promotor_-10 complement(192996..193014) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193009) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" promotor_-35 complement(193030..193037) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" gene complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" CDS complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" gene complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" promotor_-10 complement(194051..194070) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(194072) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" promotor_-35 complement(194085..194086) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 194145..194152 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 194167..194186 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 194178 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" tRNA 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" tRNA 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" tRNA 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" tRNA 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" tRNA 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" downshifts 194624 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" S_feature 194669..194786 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194787..194796 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194788 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" promotor_-10 194808..194823 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" gene 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" CDS 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" gene 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" downshifts complement(195844) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(196002..196102) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 196032 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" upshifts complement(196042) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 196101..196108 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 196123..196142 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 196132..196212 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 196132 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" CDS 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" gene 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" CDS 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" gene 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" CDS 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" gene 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" downshifts 199838 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" promotor_-35 199862..199870 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199878 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" promotor_-10 199884..199903 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199930..199935 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199951..199970 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199957 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_feature 200001..200017 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 200014 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_RNA 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" gene 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" S_feature 200188..200276 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" gene 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" S_feature complement(201802..202546) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 202065 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" CDS 202126..202266 /gene="ybbU" /locus_tag="BSU_01790" /old_locus_tag="BSU01790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513939.1" /translation="MSKSERTSTVEKWIKEVDGTGPDYRSTMAIDLRCFLIRSVNQVK RH*" gene 202126..202266 /gene="ybbU" /locus_tag="BSU_01790" /old_locus_tag="BSU01790" CDS complement(202547..203458) /gene="alkA" /locus_tag="BSU_01800" /old_locus_tag="BSU01800" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7565865, 8376346, 16468998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7565865, 8376346, 16468998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-3-methyladenine glycosylase; prophage 1 region" /protein_id="NP_388061.1" /db_xref="EnsemblGenomes-Gn:BSU01800" /db_xref="EnsemblGenomes-Tr:CAB11956" /db_xref="GOA:P37878" /db_xref="InterPro:IPR000035" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR012904" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR037046" /db_xref="SubtiList:BG10165" /db_xref="UniProtKB/Swiss-Prot:P37878" /translation="MTWHEVNDVIVITLPEIFDMNANLGYLTREKNECMYEIENNIIT KVIAIGEIRSLVQVSVINNKQMIVQFLNDSRPVEQWKREEIVKYIHEWFDLDNDLTPF YEMAKADPLLKMPARKFYGLRVIGIPDLFEALCWGVLGQQINLAFAYSLKKQFVEAFG DSIEWNGKKYWVFPPYERIARLTPTDLADIKMTVKKSEYIIGIARLMASGELSREKLM KMNFKDAEKNLIKIRGIGPWTANYVLMRCLRFPTAFPIDDVGLIHSIKILRNMNRKPT KDEILEISVPWKEWQSYATFYLWRVLY*" gene complement(202547..203458) /gene="alkA" /locus_tag="BSU_01800" /old_locus_tag="BSU01800" misc_feature complement(203505..203524) /Source="Nicolas_upshift_promotors" /id="U125" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.947052947052947" /psig="0.963036963036963" /xcortree=772 /SigmaFactorBS="aaaaaataaggtggttagaatgtaatagcaagataacaaaat gagtaaagatgattaTGTGATAAACTAATTTCAACcagcgtgagttttcttataatta t" /listShort="alkA, S70" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(203521) /Source="Nicolas_upshifts" /id="U125" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.947052947052947" /psig="0.963036963036963" /xcortree=772 /SigmaFactorBS="aaaaaataaggtggttagaatgtaatagcaagataacaaaat gagtaaagatgattaTGTGATAAACTAATTTCAACcagcgtgagttttcttataatta t" /listShort="alkA, S70" /GFF_Attribute="listLong" promotor_-35 203570..203576 /Source="Nicolas_upshift_promotors" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203591..203610 /Source="Nicolas_upshift_promotors" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203603 /Source="Nicolas_upshifts" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" CDS 203729..204364 /gene="adaA" /locus_tag="BSU_01810" /old_locus_tag="BSU01810" /EC_number="2.1.1.63" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1744039, 2120677, 7565865, 8376346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744039, 2120677, 7565865, 8376346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family)" /protein_id="NP_388062.1" /db_xref="EnsemblGenomes-Gn:BSU01810" /db_xref="EnsemblGenomes-Tr:CAB11957" /db_xref="GOA:P19219" /db_xref="InterPro:IPR004026" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR016220" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG10166" /db_xref="UniProtKB/Swiss-Prot:P19219" /translation="MPDSINNGHKESHDHRISNDAEMITDEKWQAIINNDAAYNNQFF YAVKSTGIFCKPSCKSRVPKKENVCIFPNTEQALRANFRPCKRCKPTNEKMPDSEWVD LITEYIDKNFTEKLTLESLADICHGSPYHMHRTFKKIKGITLVEYIQQVRVHAAKKYL IQTNKAIGDIAICVGIANAPYFITLFKKKTGQTPARFRQMSKMEETYNGNK*" gene 203729..204364 /gene="adaA" /locus_tag="BSU_01810" /old_locus_tag="BSU01810" CDS 204351..204890 /gene="adaB" /locus_tag="BSU_01820" /old_locus_tag="BSU01820" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1744039, 2120677, 7565865, 8376346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744039, 2120677, 7565865, 8376346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-methylguanine-DNA methyltransferase; prophage1 region" /protein_id="NP_388063.1" /db_xref="EnsemblGenomes-Gn:BSU01820" /db_xref="EnsemblGenomes-Tr:CAB11958" /db_xref="GOA:P19220" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10167" /db_xref="UniProtKB/Swiss-Prot:P19220" /translation="METNKPTLYWSLLMFKDWNFYIASTLKGLVFVGSQNKPIEELFE WARKRFPGSLLVEDDDKLEPYAVEITQYLEGKRKNFTVPVEYAGTQFQLAVWNALCEI PYGQTKSYSDIANDINKPAAVRAVGAAIGANPVLITVPCHRVIGKNGSLTGYRGGFEM KTLLLDLEKRASSEMDVPH*" gene 204351..204890 /gene="adaB" /locus_tag="BSU_01820" /old_locus_tag="BSU01820" S_feature 204891..204975 /Source="Nicolas_S_feature" /locus_tag="new_204891_204975" /HighExp="Sw, BC, S8, S6, S7, S3, G135, S4, G180, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.77593299999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S71" promotor_-35 204954..204961 /Source="Nicolas_upshift_promotors" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204976..204995 /Source="Nicolas_upshift_promotors" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 204977..205210 /Source="Nicolas_S_feature" /locus_tag="new_204977_205210" /HighExp="HiOs, Heat, HiTm, MG 150, dia15, MG-0.2, Lbtran, GM-0.2, M9-stat, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S72" upshifts 204977 /Source="Nicolas_upshifts" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" downshifts 205167 /Source="Nicolas_upshifts" /id="D66" /incds=0 /nref=60 /ntot=223 /MaxReadThrough="6.74927" /MaxDrop="5.18296" /score="13.5044076" /energy="-17.5" /TU="U127" /idTUdmin="U126" /TUdmin=1344 /isTUend="FALSE" S_feature 205212..205408 /Source="Nicolas_S_feature" /locus_tag="new_205212_205408" /HighExp="Heat, G135, G180, UNK1, S8, C30, Gly, GM-0.2, G150, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S73" CDS 205409..206926 /gene="ndhF" /locus_tag="BSU_01830" /old_locus_tag="BSU01830" /EC_number="1.6.-.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658656, 15849754, 16850406, 17015645, 6816592, 7565865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase; prophage 1 region" /protein_id="NP_388064.1" /db_xref="EnsemblGenomes-Gn:BSU01830" /db_xref="EnsemblGenomes-Tr:CAB11959" /db_xref="GOA:P39755" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="SubtiList:BG10949" /db_xref="UniProtKB/Swiss-Prot:P39755" /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGI LALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSY RKYFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISG RLFLLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPA AQWPFQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLASIS VLIGTGISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQ AGSAVGRHEVSTRTNERTSYLWVMAGRILSLVIGVAFWLTAPGDGYHLISALILGWSL SVSWDQLVAFGEGRIGRIAGLTVLGGAALVYFIIHHLFYKWLHTTIFQSVQPPMSAVM IVVCLLLFGSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS*" gene 205409..206926 /gene="ndhF" /locus_tag="BSU_01830" /old_locus_tag="BSU01830" CDS 206941..209556 /gene="ybcC" /locus_tag="BSU_01845" /old_locus_tag="BSU01845" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved transmembrane protein coupled to NADH-ubiquinone oxidoreductase chain 5 homolog; prophage 1 region" /protein_id="NP_388065.2" /db_xref="EnsemblGenomes-Gn:BSU01845" /db_xref="EnsemblGenomes-Tr:CAB11960" /db_xref="InterPro:IPR018752" /db_xref="SubtiList:BG12706" /db_xref="UniProtKB/Swiss-Prot:O34688" /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIS TFAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQR WLDSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVSECSGLDHIENVFMQPL SSYIENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPAL SKKQRERVKGWPKEAHLALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQS SHEHALLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWS QMTASEQNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGREKSALAQ LAFCIDVRSEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNK IKEFADEDVFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFV PRKAGRFIRNLREAWLRKPDTKLSLHHDATEAEIPVGFTDEEKVNYARQALKMMGLTE NIAPLVVICGHGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLAEG IKIPEDTVFAAAEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQ LPNFQSKLKNPKAEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHN YDWKQDESGELLANIIVGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQ GNASDLLAGLPWQSVMESDHEAYHSPLRLLILIQAPREYVERLLNHDSAFLQKVQNGW VRLASLDPEGCWESW*" gene 206941..209556 /gene="ybcC" /locus_tag="BSU_01845" /old_locus_tag="BSU01845" S_feature 209557..209632 /Source="Nicolas_S_feature" /locus_tag="new_209557_209632" /HighExp="Heat, G180, G135, C30, GM-0.2, UNK1, GM-0.1, BMM, G150, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S74" CDS 209633..210160 /gene="ybcF" /locus_tag="BSU_01860" /old_locus_tag="BSU01860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; prophage 1 region" /protein_id="NP_388067.1" /db_xref="EnsemblGenomes-Gn:BSU01860" /db_xref="EnsemblGenomes-Tr:CAB11962" /db_xref="GOA:O34823" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12708" /db_xref="UniProtKB/Swiss-Prot:O34823" /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGASI SHPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNGLTQLETMKDKIQTLDYLFQN CKPEFLGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVNHKGGKPSIAEV PDVKTGQAMPDHCLS*" gene 209633..210160 /gene="ybcF" /locus_tag="BSU_01860" /old_locus_tag="BSU01860" CDS 210224..210514 /gene="ybcH" /locus_tag="BSU_01870" /old_locus_tag="BSU01870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; prophage 1 region" /protein_id="NP_388068.1" /db_xref="EnsemblGenomes-Gn:BSU01870" /db_xref="EnsemblGenomes-Tr:CAB11963" /db_xref="SubtiList:BG12709" /db_xref="UniProtKB/Swiss-Prot:O34795" /translation="MSANLTDFVTKTIEEMNSFDRENMECIKKLIRKAIDFYHLKSYE EVEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY*" gene 210224..210514 /gene="ybcH" /locus_tag="BSU_01870" /old_locus_tag="BSU01870" CDS 210572..210946 /gene="ybcI" /locus_tag="BSU_01880" /old_locus_tag="BSU01880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage 1 region" /protein_id="NP_388069.1" /db_xref="EnsemblGenomes-Gn:BSU01880" /db_xref="EnsemblGenomes-Tr:CAB11964" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12710" /db_xref="UniProtKB/Swiss-Prot:O34380" /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNL KGILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSR TGERVMVFKLCNDLEKNLEKIL*" gene 210572..210946 /gene="ybcI" /locus_tag="BSU_01880" /old_locus_tag="BSU01880" S_feature 210947..211412 /Source="Nicolas_S_feature" /locus_tag="new_210947_211412" /HighExp="Heat, G135, G180, C30, S8, Etha, S7, GM-0.1, GM-0.2, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S75" promotor_-10 complement(211327..211345) /Source="Nicolas_upshift_promotors" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(211335) /Source="Nicolas_upshifts" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(211360..211366) /Source="Nicolas_upshift_promotors" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211393..211400 /Source="Nicolas_upshift_promotors" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211413..211432 /Source="Nicolas_upshift_promotors" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211414 /Source="Nicolas_upshifts" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" CDS 211429..211731 /gene="ybzH" /locus_tag="BSU_01889" /old_locus_tag="BSU01889" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family); prophage 1 region" /protein_id="YP_003097670.1" /db_xref="EnsemblGenomes-Gn:BSU01889" /db_xref="EnsemblGenomes-Tr:CAX52540" /db_xref="GOA:C0H3S9" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S9" /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCV SQITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI*" gene 211429..211731 /gene="ybzH" /locus_tag="BSU_01889" /old_locus_tag="BSU01889" downshifts 211724 /Source="Nicolas_upshifts" /id="D67" /incds=0 /nref=175 /ntot=256 /MaxReadThrough="5.31372" /MaxDrop="5.98354" /score="13.6598797" /energy="-10.8" /TU="U129" /idTUdmin="U127" /TUdmin=25 /isTUend="FALSE" S_feature 211769..211858 /Source="Nicolas_S_feature" /locus_tag="new_211769_211858" /HighExp="dia5, Diami, C30, Heat, dia15, T2.0H, S8, S1, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S76" CDS 211859..213031 /gene="ybcL" /locus_tag="BSU_01890" /old_locus_tag="BSU01890" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15812018, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter; prophage 1 region" /protein_id="NP_388070.1" /db_xref="EnsemblGenomes-Gn:BSU01890" /db_xref="EnsemblGenomes-Tr:CAB11965" /db_xref="GOA:O34663" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12711" /db_xref="UniProtKB/Swiss-Prot:O34663" /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQ LITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARII MAMGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKS VFGAIALLGLIAMVVIFFTLPYTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYS VAYTYLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMTL HIVTLILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSM MQFAMAVGAGIGGVFVENVSLASITWVGALGVMIAIIASLLIFNSQPKQALKDINQ*" gene 211859..213031 /gene="ybcL" /locus_tag="BSU_01890" /old_locus_tag="BSU01890" promotor_-35 212376..212383 /Source="Nicolas_upshift_promotors" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 212397..212416 /Source="Nicolas_upshift_promotors" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 212401 /Source="Nicolas_upshifts" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 213016 /Source="Nicolas_upshifts" /id="D68" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="0.16425" /MaxDrop="4.4712" /score="19.9212489" /energy="-11" /TU="NA" /idTUdmin="U129" /TUdmin="-3" /isTUend="TRUE" CDS 213155..213469 /gene="ybcM" /locus_tag="BSU_01900" /old_locus_tag="BSU01900" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388071.1" /db_xref="EnsemblGenomes-Gn:BSU01900" /db_xref="EnsemblGenomes-Tr:CAB11983" /db_xref="GOA:O31421" /db_xref="SubtiList:BG12712" /db_xref="UniProtKB/Swiss-Prot:O31421" /translation="MRFLKALPRRAEVQYDCLDRTLETQENVNLNIRVNVKEVATWGV NTCIISLKGLDNADDRFVLPEVNTALALFPLSIAADCLLMLPCISVVMSISSVMKSVT VE*" gene 213155..213469 /gene="ybcM" /locus_tag="BSU_01900" /old_locus_tag="BSU01900" misc_feature 213273..213274 /Source="Nicolas_upshift_promotors" /id="U131" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.908091908091908" /psig="0.014985014985015" /xcortree=18 /SigmaFactorBS="aacacaagagaacgtaaacctgaacatccgcgtaaacgtcaa ggaagttgCCacttggggagtaaacacttgcatcatctcgctgaaaggcctagacaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 213283 /Source="Nicolas_upshifts" /id="U131" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.908091908091908" /psig="0.014985014985015" /xcortree=18 /SigmaFactorBS="aacacaagagaacgtaaacctgaacatccgcgtaaacgtcaa ggaagttgCCacttggggagtaaacacttgcatcatctcgctgaaaggcctagacaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 213349 /Source="Nicolas_upshifts" /id="D69" /incds=1 /nref=5 /ntot=15 /MaxReadThrough="0.469730000000001" /MaxDrop="5.4933" /score="-8.96893905" /energy="-9.8" /TU="NA" /idTUdmin="U131" /TUdmin=0 /isTUend="TRUE" promotor_-35 213850..213857 /Source="Nicolas_upshift_promotors" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 213870 /Source="Nicolas_upshifts" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" promotor_-10 213871..213890 /Source="Nicolas_upshift_promotors" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 213878..213940 /Source="Nicolas_S_feature" /locus_tag="new_213878_213940" /HighExp="M9-stat, T5.0H, T3.0H, T2.30H, T4.0H, T3.30H, T1.30H, T1.0H, T0.0H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S77" CDS 213941..214108 /gene="skfA" /locus_tag="BSU_01910" /old_locus_tag="BSU01910" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type f: factor" /codon_start=1 /transl_table=11 /product="sporulation killing factor A" /protein_id="NP_388072.1" /db_xref="EnsemblGenomes-Gn:BSU01910" /db_xref="EnsemblGenomes-Tr:CAB11984" /db_xref="GOA:O31422" /db_xref="InterPro:IPR030919" /db_xref="SubtiList:BG12713" /db_xref="UniProtKB/Swiss-Prot:O31422" /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRV CALPHPAMRAI*" gene 213941..214108 /gene="skfA" /locus_tag="BSU_01910" /old_locus_tag="BSU01910" downshifts complement(213954) /Source="Nicolas_upshifts" /id="D70" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="0.99059" /MaxDrop="3.89647" /score="2.42246888" /energy="-3.5" /TU="NA" /idTUdmin="U134" /TUdmin=2289 /isTUend="FALSE" downshifts 214098 /Source="Nicolas_upshifts" /id="D71" /incds=0 /nref=24 /ntot=172 /MaxReadThrough="8.08284" /MaxDrop="7.24265" /score="-7.12226565" /energy="-13" /TU="U132" /idTUdmin="U131" /TUdmin=749 /isTUend="FALSE" CDS 214175..215407 /gene="skfB" /locus_tag="BSU_01920" /old_locus_tag="BSU01920" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 18307109, 23282011, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 18307109, 23282011, 26284661; Product type f: factor" /codon_start=1 /transl_table=11 /product="synthesis of sporulation killing factor A" /protein_id="NP_388073.2" /db_xref="EnsemblGenomes-Gn:BSU01920" /db_xref="EnsemblGenomes-Tr:CAB11985" /db_xref="GOA:O31423" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR030915" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12714" /db_xref="UniProtKB/Swiss-Prot:O31423" /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLA FLLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLD SYLPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTG GEAKLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNT HDQLRGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFR AGKTLSVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCT PGYLAWYIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIE LSEPDLPFQKEVKAGIQE*" gene 214175..215407 /gene="skfB" /locus_tag="BSU_01920" /old_locus_tag="BSU01920" CDS 215404..216894 /gene="skfC" /locus_tag="BSU_01935" /old_locus_tag="BSU01935" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export" /protein_id="YP_003097671.1" /db_xref="EnsemblGenomes-Gn:BSU01935" /db_xref="EnsemblGenomes-Tr:CAX52541" /db_xref="GOA:O31425" /db_xref="InterPro:IPR003675" /db_xref="UniProtKB/Swiss-Prot:O31425" /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQ FIKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQ NQSFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGT GKKEEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQV ESTFGVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTI VNAYDARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQI FYGIGAGLISLGVTSLLFNLLEKKQYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIG EEVIYRLLMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLG VLFIKFGFICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL*" gene 215404..216894 /gene="skfC" /locus_tag="BSU_01935" /old_locus_tag="BSU01935" promotor_-35 216301..216309 /Source="Nicolas_upshift_promotors" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(216318..216337) /Source="Nicolas_upshift_promotors" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 216321..216339 /Source="Nicolas_upshift_promotors" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216321 /Source="Nicolas_upshifts" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" upshifts complement(216331) /Source="Nicolas_upshifts" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(216350..216359) /Source="Nicolas_upshift_promotors" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 216913..217632 /gene="skfE" /locus_tag="BSU_01950" /old_locus_tag="BSU01950" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export; ABC transporter (binding protein)" /protein_id="NP_388077.1" /db_xref="EnsemblGenomes-Gn:BSU01950" /db_xref="EnsemblGenomes-Tr:CAB11989" /db_xref="GOA:O31427" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12718" /db_xref="UniProtKB/Swiss-Prot:O31427" /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTT TIRCLTGLYKPDKGDILIEGSPPGDINVQKKVALIPDQPYLYPALTAAEHIQFRARGY HPGKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPT VGLDIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVIETADRVILIRDGKLMQDLYVPQ FEEQAEWRKEVIRLLGEWSDE*" gene 216913..217632 /gene="skfE" /locus_tag="BSU_01950" /old_locus_tag="BSU01950" CDS 217697..219040 /gene="skfF" /locus_tag="BSU_01960" /old_locus_tag="BSU01960" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export; ABC transporter (permease)" /protein_id="NP_388078.2" /db_xref="EnsemblGenomes-Gn:BSU01960" /db_xref="EnsemblGenomes-Tr:CAB11990" /db_xref="GOA:O31428" /db_xref="InterPro:IPR030920" /db_xref="SubtiList:BG12719" /db_xref="UniProtKB/Swiss-Prot:O31428" /translation="MPFLIMLLFVGAIGFQVSFVSRSTTWDMSIAGWVLTGVFILYTA FGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFSVTWKALLWIISAIFGDVLIVLL SGDHINLLGRSIIFVGLFFIAEVWLMSVSCARTVKKMKRVYVLVFLLMLGIYSICLYR FFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIGIITVSFMTIAFTSRQVEMKE SLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGIWSFLWLELLLFKKYLFFHS IHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSGIVRHSQSGTLHLFPGALW KKIIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIYIWFMTIRLFAFTHTNRN DIKLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVCIGSLSWCLFYRFR*" gene 217697..219040 /gene="skfF" /locus_tag="BSU_01960" /old_locus_tag="BSU01960" CDS 219087..219602 /gene="skfG" /locus_tag="BSU_01970" /old_locus_tag="BSU01970" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export" /protein_id="NP_388079.2" /db_xref="EnsemblGenomes-Gn:BSU01970" /db_xref="EnsemblGenomes-Tr:CAB11991" /db_xref="GOA:O31429" /db_xref="InterPro:IPR016024" /db_xref="SubtiList:BG12720" /db_xref="UniProtKB/Swiss-Prot:O31429" /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEA LKEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPF VIKIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGK LIAFQLKDKED*" gene 219087..219602 /gene="skfG" /locus_tag="BSU_01970" /old_locus_tag="BSU01970" CDS 219607..220032 /gene="skfH" /locus_tag="BSU_01980" /old_locus_tag="BSU01980" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="sibling killing effect; sporulation killing factor biosynthesis and export" /protein_id="NP_388080.2" /db_xref="EnsemblGenomes-Gn:BSU01980" /db_xref="EnsemblGenomes-Tr:CAB11992" /db_xref="GOA:O31430" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12721" /db_xref="UniProtKB/Swiss-Prot:O31430" /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNC HQLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVT TCHVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL*" gene 219607..220032 /gene="skfH" /locus_tag="BSU_01980" /old_locus_tag="BSU01980" S_feature 220033..220103 /Source="Nicolas_S_feature" /locus_tag="new_220033_220103" /HighExp="T4.0H, T5.0H, Pyr, T3.30H, S2, G/S, LoTm, T3.0H, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S78" downshifts 220060 /Source="Nicolas_upshifts" /id="D72" /incds=0 /nref=22 /ntot=127 /MaxReadThrough="4.07672" /MaxDrop="3.58139" /score="5.89945455" /energy="-8.8" /TU="U132" /idTUdmin="U133" /TUdmin=0 /isTUend="TRUE" S_feature 220105..220278 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 220279..221256 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" gene 220279..221256 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" CDS 221258..221929 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" gene 221258..221929 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" promotor_-35 221823..221829 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 221843..221862 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 221861 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" CDS 221950..222912 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" gene 221950..222912 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" promotor_-35 222924..222926 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 222942..222961 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 222945 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" CDS 222971..223234 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" gene 222971..223234 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" downshifts 223175 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" CDS complement(223219..223989) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" gene complement(223219..223989) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" CDS complement(224075..224932) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" gene complement(224075..224932) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" downshifts complement(224097) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(224146..224165) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(224179..224188) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(224181) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(224945..224964) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(224970) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" promotor_-35 complement(224979..224986) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 225000..225007 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 225021..225039 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 225023 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" CDS 225064..226248 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" gene 225064..226248 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" downshifts 226234 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" promotor_-35 226402..226408 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226422..226441 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 226436..226565 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 226436 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" CDS 226566..227954 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" gene 226566..227954 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" downshifts 227962 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" promotor_-35 228000..228006 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228020..228031 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 228021 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" CDS 228066..228314 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" gene 228066..228314 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" CDS 228331..228522 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" gene 228331..228522 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" downshifts 228504 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" CDS complement(228549..229352) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" gene complement(228549..229352) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" promotor_-10 complement(229374..229392) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(229382) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" promotor_-35 complement(229403..229411) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 229466..229472 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 229487..229505 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 229493 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" CDS 229525..230778 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" gene 229525..230778 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" misc_feature 229837..229844 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 229847 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 230771 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" CDS complement(230819..231079) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" gene complement(230819..231079) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" downshifts complement(230838) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" promotor_-10 complement(231109..231127) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(231118) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" promotor_-35 complement(231141..231147) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 231271..231278 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231288 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" promotor_-10 231294..231313 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231348..232967 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" gene 231348..232967 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" downshifts 232950 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" CDS complement(233014..233895) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" gene complement(233014..233895) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" downshifts complement(233025) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" upshifts complement(233938) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" promotor_-10 complement(233947..233963) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(233972..233978) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(233994..235328) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" gene complement(233994..235328) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" promotor_-35 234976..234985 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 234998..235624 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 234998..235017 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234998 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" S_feature complement(235329..235401) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(235361..235461) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(235401) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" S_feature complement(235403..235489) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(235479..235498) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(235493) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" promotor_-35 complement(235511..235518) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 235625..235873 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" gene 235625..235873 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" promotor_-35 235897..235904 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 235904 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" promotor_-10 235920..235939 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 235965..236882 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" gene 235965..236882 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" CDS 236879..238129 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" gene 236879..238129 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" downshifts 238119 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" CDS complement(238164..238448) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" gene complement(238164..238448) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo downshifts complement(238217) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" CDS complement(238354..238476) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" gene complement(238354..238476) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo S_feature complement(238449..238569) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(238554..238572) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238569) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" S_feature complement(238571..238643) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(238589..238594) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(238644..239555) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" gene complement(238644..239555) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" S_feature complement(239556..239643) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(239644..241842) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" gene complement(239644..241842) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" misc_feature complement(241877..241895) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(241889) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" CDS complement(241917..242837) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" gene complement(241917..242837) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" CDS complement(242834..243661) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " gene complement(242834..243661) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" misc_feature complement(243688..243707) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(243695) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" promotor_-35 243835..243838 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 243853..243872 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 243858 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" CDS 243892..245046 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" gene 243892..245046 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" downshifts 245027 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" promotor_-35 245107..245112 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 245121 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" promotor_-10 245127..245145 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 245161..245168 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 245183..245202 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 245183 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" CDS 245190..246131 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" gene 245190..246131 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" CDS 246094..246492 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" gene 246094..246492 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" promotor_-10 complement(246186..246200) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(246196) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(246216..246221) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 246479 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" promotor_-35 246548..246555 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 246570..246589 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 246583..246657 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 246583 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" CDS 246658..247548 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" gene 246658..247548 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" promotor_-35 246892..246899 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 246908 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" promotor_-10 246913..246931 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 247549..247743 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 247744..248277 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" gene 247744..248277 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" CDS 248268..248756 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" gene 248268..248756 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" CDS 248749..249540 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" gene 248749..249540 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" downshifts 249515 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" CDS 249595..249873 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" gene 249595..249873 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" promotor_-35 249916..249925 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 249934 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" promotor_-10 249938..249953 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249979..251319 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" gene 249979..251319 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" downshifts 251319 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" upshifts 251385 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" misc_feature 251388..251407 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 251427..252314 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" gene 251427..252314 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" S_feature 252315..252458 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 252430..252437 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 252451..252470 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 252460 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" CDS 252514..253482 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" gene 252514..253482 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" promotor_-10 complement(253336..253354) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(253353) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(253370..253375) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 253479 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" downshifts complement(253518) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" CDS complement(253518..254762) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" gene complement(253518..254762) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" promotor_-10 complement(254796..254814) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(254805) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(254825..254833) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(254833..254851) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(254849) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(254867..254872) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(254907..256802) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" gene complement(254907..256802) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" downshifts complement(254923) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" misc_feature 256668..256687 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 256685 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(256823..257572) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" gene complement(256823..257572) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" S_feature 257545..257726 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(257573..257643) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(257632..257651) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(257647) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" promotor_-35 complement(257667..257674) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 257713..257720 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 257728 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" promotor_-10 257733..257752 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 257791..258498 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" gene 257791..258498 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" promotor_-35 258464..258465 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258481..258495 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258491 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" CDS 258532..258807 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" gene 258532..258807 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" promotor_-10 complement(258590..258608) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(258596) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(258623..258629) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 258799 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" promotor_-35 258850..258854 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258870..258889 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258876 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" S_feature 258887..259015 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 259016..260086 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" gene 259016..260086 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" downshifts 260075 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" CDS complement(260123..261535) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" gene complement(260123..261535) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" downshifts complement(260140) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" S_feature complement(261536..261647) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(261620..261639) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(261647) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" promotor_-35 complement(261654..261661) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(261656..262603) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" gene complement(261656..262603) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" promotor_-10 complement(262641..262660) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(262658) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" promotor_-35 complement(262675..262682) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(262732..264168) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" gene complement(262732..264168) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" downshifts complement(262747) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" CDS complement(264191..265174) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" gene complement(264191..265174) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" promotor_-10 complement(265268..265285) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 265273..265292 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(265275) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 265279 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(265301..265308) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265476..266708 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" gene 265476..266708 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" CDS 266719..267663 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" gene 266719..267663 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" downshifts 267640 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" promotor_-35 267760..267767 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 267772..267889 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 267772 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" promotor_-10 267781..267800 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 267890..268816 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" gene 267890..268816 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" CDS 268846..270312 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" gene 268846..270312 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" CDS 270396..271763 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" gene 270396..271763 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" CDS 271800..273167 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" gene 271800..273167 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" promotor_-35 273181..273188 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 273203..273220 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 273206 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" CDS 273237..273938 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" gene 273237..273938 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" downshifts 273888 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" downshifts 273932 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" CDS 274029..275561 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" gene 274029..275561 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" promotor_-35 275573..275576 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275591..275610 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 275603..275837 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 275603 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" CDS 275838..276758 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" gene 275838..276758 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" promotor_-35 276760..276767 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276782..276801 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276792 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" misc_RNA 276815..277062 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" gene 276815..277062 /gene="tboW" /locus_tag="BSU_misc_RNA_6" downshifts 277031 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" CDS 277160..277321 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" gene 277160..277321 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" promotor_no_box 277238..277338 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 277298 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 277342..278280 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" gene 277342..278280 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" downshifts 277386 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" misc_feature 278303..278322 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 278308..278376 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 278308 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" CDS 278377..279057 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" gene 278377..279057 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" CDS 279059..279994 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" gene 279059..279994 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" CDS 280086..281009 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" gene 280086..281009 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" S_feature complement(280556..281740) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 281028..281714 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" gene 281028..281714 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" CDS complement(281675..281809) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" gene complement(281675..281809) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" downshifts 281709 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" CDS complement(281769..282155) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" gene complement(281769..282155) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" downshifts complement(281785) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(282181..282199) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282200) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" promotor_-35 complement(282213..282219) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(282233..283231) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(282276) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" promotor_-35 282412..282417 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 282431 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" promotor_-10 282433..282451 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282445) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" promotor_-10 complement(282447..282461) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(282467) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" promotor_-35 complement(282469..282473) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282469..282897 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" gene 282469..282897 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" downshifts 282876 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" promotor_-35 282942..282948 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 282961..282980 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 282963 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" CDS 283003..283734 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" gene 283003..283734 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" promotor_-10 complement(283205..283224) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283231) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" promotor_-35 complement(283238..283245) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 283652 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" CDS 283816..283992 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" gene 283816..283992 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" promotor_-35 283944..283950 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 283957..283974 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 283968 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" CDS 284011..285762 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" gene 284011..285762 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" promotor_-10 complement(284065..284080) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(284071) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(284093..284102) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 285775..285987 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" gene 285775..285987 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" S_feature 285988..286047 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 286048..286776 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" gene 286048..286776 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" downshifts complement(286056) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" CDS complement(286773..287420) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" gene complement(286773..287420) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" promotor_-10 complement(287435..287454) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 287448..287454 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(287449) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" promotor_-10 287469..287488 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(287469..287473) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 287471 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" CDS 287499..288611 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" gene 287499..288611 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" upshifts complement(287845) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(287848..287867) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(287883..287887) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 288605 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" CDS complement(288653..290092) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" gene complement(288653..290092) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" downshifts complement(288660) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" CDS complement(290132..290698) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" gene complement(290132..290698) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" promotor_-10 complement(290736..290755) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(290750) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" promotor_-35 complement(290770..290777) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 290852..290858 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290874..290891 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290880 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" CDS 290915..292042 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" gene 290915..292042 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" downshifts 292015 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" promotor_-35 292139..292145 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 292159..292178 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 292159 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" CDS 292205..292843 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" gene 292205..292843 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" downshifts 292829 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" S_feature 292874..293464 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(292881..293264) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" gene complement(292881..293264) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" downshifts complement(292905) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(293294..293313) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293301) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" promotor_-35 complement(293327..293334) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293436..293439 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 293455..293474 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 293466 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" CDS 293499..294575 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" gene 293499..294575 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" downshifts 294569 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" CDS complement(294615..295571) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" gene complement(294615..295571) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" downshifts complement(294643) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" CDS complement(295584..296285) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" gene complement(295584..296285) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" promotor_-10 complement(296309..296328) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(296315) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" promotor_-35 complement(296344..296347) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 296365..296368 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 296384..296403 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 296394 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" CDS 296429..297169 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" gene 296429..297169 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" CDS 297170..298330 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" gene 297170..298330 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" promotor_-35 298381..298389 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 298401..298419 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 298401 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" CDS 298466..299398 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" gene 298466..299398 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" CDS complement(299438..300502) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" gene complement(299438..300502) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" downshifts complement(299439) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" S_feature complement(300503..300693) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(300525..300656) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " gene complement(300525..300656) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" promotor_-10 complement(300678..300697) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300698) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" promotor_-35 complement(300712..300719) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 300830..302248 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" gene 300830..302248 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" promotor_-10 complement(302291..302309) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302299) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(302323..302330) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 302355..302434 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 302355 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" promotor_-35 302357..302363 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 302378..302395 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 302435..303796 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" gene 302435..303796 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" S_feature 303797..304377 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(303804..304307) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" gene complement(303804..304307) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" S_feature complement(304308..304389) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 304379 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" promotor_-10 complement(304381..304400) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 304382..304401 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(304390) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" promotor_-35 complement(304413) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 304430..305551 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" gene 304430..305551 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" downshifts 305545 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" promotor_-35 305592..305598 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 305613..305631 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 305616 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 305658..306434 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" gene 305658..306434 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" downshifts complement(305665) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" CDS 306459..308144 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" gene 306459..308144 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" promotor_no_box 307399..307499 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 307459 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 307525 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" downshifts 308141 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" promotor_-35 308235..308242 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308258..308277 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308264 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 308332..309291 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" gene 308332..309291 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" promotor_-35 308887..308893 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308907..308926 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308911 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" downshifts 309263 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" CDS 309347..310042 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" gene 309347..310042 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" CDS 310000..310842 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" gene 310000..310842 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" downshifts 310829 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" CDS complement(310880..311875) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" gene complement(310880..311875) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" promotor_-35 311831..311838 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 311853..311872 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 311859..312061 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 311859 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" promotor_-10 complement(311907..311926) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(311915) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" promotor_-35 complement(311941..311948) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 312045..312054 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 312063..312158 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 312063 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" promotor_-10 312067..312082 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 312159..312758 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" gene 312159..312758 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" CDS 312780..313361 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" gene 312780..313361 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" CDS 313396..313974 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" gene 313396..313974 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" CDS 314025..314798 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" gene 314025..314798 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" downshifts 314785 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" CDS 314883..316496 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" gene 314883..316496 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" CDS 316512..317603 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" gene 316512..317603 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" downshifts 317577 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" promotor_-35 317657..317664 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 317679..317698 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 317687 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" CDS 317725..318927 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" gene 317725..318927 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" downshifts 318907 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" CDS complement(319180..320352) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" gene complement(319180..320352) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" downshifts complement(319195) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" CDS complement(320421..320723) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" gene complement(320421..320723) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" downshifts complement(320449) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(320706..320725) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(320725) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" promotor_-35 complement(320739..320745) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 320972..320991 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 320972 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" CDS 321013..322269 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" gene 321013..322269 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" downshifts complement(321021) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" CDS 322271..323119 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" gene 322271..323119 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" CDS 323119..324000 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" gene 323119..324000 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" downshifts 323981 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" downshifts complement(324013) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" CDS complement(324038..325189) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" gene complement(324038..325189) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" downshifts complement(324057) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" S_feature complement(325190..325277) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 325245..325252 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(325264..325283) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 325267..325286 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(325277) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" upshifts 325280 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" promotor_-35 complement(325296..325302) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 325339..326772 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" gene 325339..326772 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" promotor_-35 326077..326085 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326097..326115 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326116 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 326754 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" promotor_-35 326815..326822 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326837..326856 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326846 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" CDS 326888..327469 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" gene 326888..327469 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" upshifts 327282 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" misc_feature 327286..327290 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 327445..327452 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 327467..327486 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 327480..327617 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 327480 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" CDS 327618..329597 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" gene 327618..329597 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" downshifts 329611 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" promotor_-35 329677..329684 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 329694 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" promotor_-10 329698..329717 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 329774..330739 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" gene 329774..330739 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" CDS 330771..332396 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" gene 330771..332396 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" downshifts 330777 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" downshifts 332383 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" CDS complement(332441..333979) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" gene complement(332441..333979) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" downshifts complement(332459) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(333033..333133) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(333073) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 333993..333997 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 334013..334032 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 334027 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" promotor_-10 complement(334059..334078) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(334062) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" CDS 334092..334556 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" gene 334092..334556 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" promotor_-35 complement(334093..334099) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 334566..334571 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 334587..334605 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 334597 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" CDS 334630..335259 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" gene 334630..335259 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" promotor_-35 335270..335279 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335293..335312 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335301 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" CDS 335329..336090 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" gene 335329..336090 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" S_feature complement(335729..336091) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 336087 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" CDS complement(336092..337432) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" gene complement(336092..337432) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" promotor_-10 complement(337459..337470) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(337469) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" promotor_-35 complement(337485..337491) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 337511..337517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 337525 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" promotor_-10 337532..337543 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 337562..338158 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" gene 337562..338158 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" promotor_-35 338166..338173 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 338187..338287 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 338187..338206 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 338187 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" downshifts complement(338283) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" CDS 338288..339106 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" gene 338288..339106 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" downshifts 339088 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" CDS complement(339156..339749) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" gene complement(339156..339749) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" downshifts complement(339163) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(339764..339783) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339779) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(339798..339801) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(339807..339955) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 339857..339864 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 339877..339896 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 339879..339987 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 339881 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" promotor_-10 complement(339949..339967) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 339955..339962 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(339965) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" promotor_-10 339977..339996 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(339983..339988) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 339989 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" CDS 340025..340585 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" gene 340025..340585 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" downshifts 340562 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" CDS complement(340613..341374) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" gene complement(340613..341374) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" downshifts complement(340637) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(341406..341425) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 341407..341414 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(341412) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" promotor_-10 341429..341448 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(341440..341445) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 341441 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" CDS 341492..342466 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" gene 341492..342466 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" S_feature 342467..342537 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 342538..343494 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" gene 342538..343494 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" promotor_-35 342953..342959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342974..342985 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342981 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" S_feature 343495..343573 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 343548..343553 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 343570..343588 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 343575 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" CDS 343578..344360 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" gene 343578..344360 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" downshifts 344325 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" S_feature 344370..344497 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 344474..344478 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344493..344512 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344499 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 344551..345462 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" gene 344551..345462 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" CDS 345479..347026 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" gene 345479..347026 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" promotor_-35 346450..346456 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 346470..346489 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 346478 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" promotor_-35 346561..346567 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 346580..346599 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 346589 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" misc_feature 347025..347029 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 347027..347149 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 347029 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 347150..348571 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" gene 347150..348571 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" S_feature complement(347670..349525) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 348551 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" S_feature 348596..348692 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 348663..348670 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348685..348704 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 348694 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" CDS 348724..349959 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" gene 348724..349959 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" promotor_-10 complement(349518..349536) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(349535) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" promotor_-35 complement(349550..349557) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(349943) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" CDS complement(349996..350853) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" gene complement(349996..350853) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" downshifts complement(350009) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" CDS complement(350858..351742) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" gene complement(350858..351742) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" upshifts complement(351794) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" promotor_-10 complement(351799..351812) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(351827..351835) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(351842..352696) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" gene complement(351842..352696) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" promotor_-10 complement(352715..352734) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(352735) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" promotor_-35 complement(352749..352752) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 352786..352805 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(352786..352804) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 352793..352857 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 352794 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" upshifts complement(352803) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(352820..352825) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 352858..353868 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" gene 352858..353868 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" S_feature 353869..356316 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(353900..355351) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" gene complement(353900..355351) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" downshifts complement(353904) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" CDS complement(355412..355732) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" gene complement(355412..355732) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" promotor_-35 355583..355588 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355602..355606 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355609 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(355641) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" promotor_-10 complement(355643..355662) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(355676..355683) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(355764..358181) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" gene complement(355764..358181) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" promotor_-10 complement(358206..358225) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(358220) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 complement(358237..358243) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(358303..360435) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" gene complement(358303..360435) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" CDS complement(360442..362757) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" gene complement(360442..362757) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" promotor_no_box complement(362776..362876) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(362816) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 362859..362866 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 362880..362899 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 362892 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" CDS 362937..364142 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" gene 362937..364142 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" downshifts 364127 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" promotor_-35 364186..364192 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 364207..364226 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 364215 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" CDS 364259..365173 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" gene 364259..365173 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" CDS 365170..365754 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" gene 365170..365754 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" promotor_-35 365765..365772 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 365786..365805 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 365796 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" CDS 365850..366035 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" gene 365850..366035 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" CDS 366063..367256 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" gene 366063..367256 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" downshifts 367248 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" S_feature 367293..368962 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(367305..367985) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" gene complement(367305..367985) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" downshifts complement(367311) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" CDS complement(367995..368858) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" gene complement(367995..368858) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" promotor_-10 complement(368880..368899) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(368892) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" S_feature complement(368894..371728) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(368914..368921) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 368931..368937 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 368952..368970 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 368964..369186 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 368964 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" CDS 369020..369217 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" gene 369020..369217 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" promotor_-35 369155..369160 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 369176..369194 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 369188 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" CDS 369236..369691 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" gene 369236..369691 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" downshifts 369666 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" promotor_-35 369714..369720 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 369727 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" promotor_-10 369734..369745 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 369773..370105 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" gene 369773..370105 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" downshifts 370086 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" promotor_-35 370191..370198 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 370214..370233 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 370218 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" CDS 370259..371692 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" gene 370259..371692 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" downshifts 371670 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" CDS complement(371729..372127) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" gene complement(371729..372127) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" promotor_no_box complement(372124..372224) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(372154..372603) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" gene complement(372154..372603) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" upshifts complement(372164) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" promotor_-10 complement(372618..372637) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(372626) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" S_feature complement(372628..372770) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(372651..372658) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(372771..374492) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" gene complement(372771..374492) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" promotor_-35 372783..372790 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 372801..375944 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 372801 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" promotor_-10 372805..372824 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(372806..372906) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(372846) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" promotor_-10 complement(374516..374534) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(374531) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" promotor_-35 complement(374548..374555) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(374603..375160) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" gene complement(374603..375160) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" downshifts complement(374606) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" CDS complement(375166..375798) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" gene complement(375166..375798) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" promotor_-10 complement(375824..375843) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(375839) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" promotor_-35 complement(375858..375861) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 375922..375925 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 375940..375959 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 375946 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" CDS 376032..376394 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" gene 376032..376394 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" downshifts 376378 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" promotor_-35 376641..376644 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 376659..376678 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 376667..376967 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 376667 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" CDS 376968..387731 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" gene 376968..387731 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" CDS 387744..398495 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" gene 387744..398495 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" CDS 390880..391020 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" gene 390880..391020 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" CDS 398532..402359 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" gene 398532..402359 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" CDS 402388..403116 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" gene 402388..403116 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" downshifts 403098 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" promotor_-35 403154..403161 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 403164 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" promotor_-10 403173..403192 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 403217..404443 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" gene 403217..404443 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" downshifts 404437 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" CDS complement(404458..405015) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" gene complement(404458..405015) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" promotor_no_box complement(404473..404573) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(404495) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" upshifts complement(404513) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(405044..405063) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(405046) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" CDS complement(405069..406007) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" gene complement(405069..406007) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" promotor_-10 complement(406046..406064) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406053) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(406080..406085) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 406131..407465 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" gene 406131..407465 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" CDS complement(407460..407627) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" gene complement(407460..407627) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo CDS complement(407638..408135) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" gene complement(407638..408135) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo misc_feature complement(408162..408181) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(408174) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" CDS complement(408240..408887) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" gene complement(408240..408887) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" promotor_-10 complement(408916..408935) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(408919) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" promotor_-35 complement(408951..408955) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(409056..409207) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(409208..409951) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" gene complement(409208..409951) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" downshifts complement(409264) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" CDS complement(409965..410669) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" gene complement(409965..410669) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" CDS complement(410656..411462) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" gene complement(410656..411462) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" promotor_-10 complement(411511..411530) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(411523) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(411544..411551) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(411578..412450) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" gene complement(411578..412450) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" promotor_-10 complement(412188..412206) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412195) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(412221..412227) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 412504..412511 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(412519..412538) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 412525..412544 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412525) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" upshifts 412533 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" CDS 412540..413154 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" gene 412540..413154 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" promotor_-35 complement(412552..412559) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 413157..414578 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" gene 413157..414578 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" CDS 414595..414822 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" gene 414595..414822 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" CDS 414819..415283 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" gene 414819..415283 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" downshifts 415264 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" misc_feature 415290..415291 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 415291 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 415350..416195 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" gene 415350..416195 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" CDS complement(416235..417713) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" gene complement(416235..417713) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" downshifts complement(416243) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" promotor_-35 417740..417742 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(417741..417760) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 417751 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 417759..417777 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(417761) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" S_feature complement(417763..418267) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(417775..417782) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 417931..417940 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 417953..417972 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 417954 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" CDS 417993..419747 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" gene 417993..419747 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" promotor_-10 complement(418264..418282) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(418277) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" promotor_-35 complement(418298..418303) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 419738 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" CDS complement(419763..419984) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" gene complement(419763..419984) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" promotor_-10 complement(420003..420014) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(420005) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" promotor_-35 complement(420029..420035) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 420050..420056 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420070..420081 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420083 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" CDS 420110..421744 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" gene 420110..421744 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" CDS 421734..422957 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" gene 421734..422957 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" CDS 422982..424103 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" gene 422982..424103 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" downshifts 424087 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" CDS complement(424208..424888) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" gene complement(424208..424888) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" CDS complement(424904..426364) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" gene complement(424904..426364) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" misc_feature 426534..426553 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 426537 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" CDS 426577..427260 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" gene 426577..427260 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" CDS 427247..428668 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" gene 427247..428668 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" downshifts 428644 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" S_feature 428689..428793 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 428783..428802 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 428795 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" downshifts complement(428827) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" CDS 428831..429979 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" gene 428831..429979 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" promotor_-35 429679..429684 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 429697 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" promotor_-10 429701..429719 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 429841..429849 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 429861..429879 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 429873 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" CDS 429963..430085 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" gene 429963..430085 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" downshifts 430072 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" downshifts complement(430140) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" CDS complement(430185..430274) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" gene complement(430185..430274) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" downshifts complement(430345) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" CDS complement(430356..430469) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" gene complement(430356..430469) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" promotor_-10 complement(430490..430509) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430501) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" promotor_-35 complement(430522..430531) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(430623..431987) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" gene complement(430623..431987) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" downshifts complement(430631) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" downshifts complement(430675) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(432023..432042) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(432039) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" promotor_-35 complement(432057..432064) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 432178..432182 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432198..432217 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432210 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" promotor_-35 432241..432248 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432262..432281 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432271..432371 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 432271 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" CDS 432372..433322 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" gene 432372..433322 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" CDS 433315..434262 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" gene 433315..434262 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" CDS 434256..435014 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" gene 434256..435014 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" CDS 435036..435989 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" gene 435036..435989 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" downshifts 435972 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" CDS complement(436036..437454) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" gene complement(436036..437454) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" downshifts complement(436057) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" CDS complement(437474..438352) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" gene complement(437474..438352) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" S_feature complement(438353..438419) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(438418..438437) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(438427) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" promotor_-35 complement(438452..438458) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(438516..439265) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" gene complement(438516..439265) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" downshifts complement(438529) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" CDS complement(439282..439569) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" gene complement(439282..439569) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" promotor_-35 439535..439542 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 439556..439575 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 439575 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(439613..439632) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(439629) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" promotor_-35 complement(439646..439653) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 439674..439681 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 439686 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" promotor_-10 439692..439711 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 439709..440023 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" gene 439709..440023 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" downshifts 440015 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" CDS complement(440025..441464) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" gene complement(440025..441464) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" promotor_-10 complement(440349..440360) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(440355) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(440374..440380) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(441507..441526) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 441508..441515 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(441514) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 441529..441548 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 441533 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" promotor_-35 complement(441537..441544) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 441571..442881 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" gene 441571..442881 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" promotor_-35 442759..442765 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 442779..442797 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 442787 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" promotor_-35 442883..442890 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 442905..442924 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 442914 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" CDS 442950..444338 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" gene 442950..444338 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" downshifts 444346 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" promotor_-35 444396..444402 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444416..444427 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444417 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" CDS 444461..445324 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" gene 444461..445324 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" CDS 445344..446129 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" gene 445344..446129 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" misc_feature 445449..445468 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 445449 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 445537 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" downshifts 446131 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" CDS complement(446174..446788) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" gene complement(446174..446788) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" downshifts complement(446185) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" CDS complement(446801..448426) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" gene complement(446801..448426) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" CDS complement(448461..449033) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" gene complement(448461..449033) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" promotor_-10 complement(449055..449074) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(449070) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" promotor_-35 complement(449088..449095) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 449155..449174 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 449167 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" CDS 449198..449551 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" gene 449198..449551 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" downshifts 449522 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" promotor_-35 449615..449622 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 449636..449655 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 449641 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" S_feature 449651..449723 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 449724..451160 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" gene 449724..451160 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" CDS 451185..451616 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" gene 451185..451616 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" CDS 451618..452739 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" gene 451618..452739 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" downshifts 452722 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" promotor_-35 452768..452771 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 452787..452806 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 452789 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" CDS 452830..453894 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" gene 452830..453894 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" promotor_-35 453064..453072 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453086..453105 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453096 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 453888 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" promotor_-35 453961..453968 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453981..454000 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453994 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" CDS 454029..454592 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" gene 454029..454592 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" S_feature 454593..455317 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(454652..455260) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" gene complement(454652..455260) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" misc_feature complement(455278..455297) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 455294..455300 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(455301) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" promotor_-10 455313..455332 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455319 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" CDS 455346..455738 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" gene 455346..455738 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" downshifts 455715 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" CDS complement(455771..455935) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" gene complement(455771..455935) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" downshifts complement(455791) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(455945..455963) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455967) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" promotor_-35 complement(455978..455984) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 455997..456004 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456018..456037 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456021 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" CDS 456068..456817 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" gene 456068..456817 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" downshifts 456794 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" downshifts complement(456870) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" promotor_-35 456900..456906 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456920..456939 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 456926..457022 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 456926 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" CDS 457023..457796 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" gene 457023..457796 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" CDS 457811..459025 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" gene 457811..459025 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" CDS 459049..459822 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" gene 459049..459822 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" CDS 459867..460589 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" gene 459867..460589 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" CDS 460592..461599 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" gene 460592..461599 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" downshifts 461085 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" promotor_no_box 461179..461279 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 461239 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" CDS 461615..462367 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" gene 461615..462367 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" promotor_-35 462365..462374 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 462388..462407 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 462398 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" CDS 462431..463072 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" gene 462431..463072 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" downshifts 463058 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" S_feature complement(463070..463495) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(463115) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" promotor_-35 463148..463154 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463168..463187 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463169 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" CDS 463245..463490 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" gene 463245..463490 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" S_feature 463491..463901 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(463496..463783) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" gene complement(463496..463783) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" misc_feature complement(463804..463823) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(463820) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" promotor_-35 463877..463881 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463898..463917 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463903 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" CDS 463934..465940 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" gene 463934..465940 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" S_feature 465941..466041 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 466042..466944 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" gene 466042..466944 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" downshifts 466924 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" promotor_-35 467017..467024 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467038..467057 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 467042..467129 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 467042 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" CDS 467130..469214 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" gene 467130..469214 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" downshifts 469201 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" promotor_-35 469243..469249 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 469263..469281 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 469275 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" S_feature 469286..469367 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 469329..469336 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 469350..469369 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 469369 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" CDS 469426..470937 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" gene 469426..470937 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" downshifts 470921 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" CDS complement(470957..471502) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" gene complement(470957..471502) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" downshifts complement(470990) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(471569..471587) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(471583) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" promotor_-35 complement(471602..471608) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 471644..471650 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 471662 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" promotor_-10 471665..471683 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 471709..472569 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" gene 471709..472569 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" CDS 472585..473088 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" gene 472585..473088 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" downshifts 473069 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" promotor_-35 473117..473124 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473138..473157 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 473140 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" CDS 473174..473725 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" gene 473174..473725 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" promotor_-35 473740..473746 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473761..473779 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 473774 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" CDS 473803..474225 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" gene 473803..474225 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" promotor_-35 474230..474238 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474249..474268 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 474268..474634 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 474268 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" promotor_no_box complement(474294..474394) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(474329..474597) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" gene complement(474329..474597) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" upshifts complement(474334) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 474591 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" promotor_-35 474671..474680 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474693..474708 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 474698 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" CDS 474731..475540 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" gene 474731..475540 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" downshifts 475521 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" CDS complement(475584..475874) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" gene complement(475584..475874) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" downshifts complement(475588) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" misc_feature complement(475902..475921) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 475902..475920 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 475908 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(475918) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" promotor_-35 475996..476003 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476017..476036 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476021 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" CDS 476059..476493 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" gene 476059..476493 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" promotor_-35 476490..476493 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 476502 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" promotor_-10 476510..476529 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 476558..478741 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" gene 476558..478741 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" downshifts 478724 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" promotor_-35 478790..478796 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478811..478829 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 478812..478943 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 478812 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" CDS 478944..480032 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" gene 478944..480032 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" CDS 480013..480864 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" gene 480013..480864 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" CDS 480875..482584 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" gene 480875..482584 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" CDS 482577..483839 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" gene 482577..483839 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" CDS 483845..485956 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" gene 483845..485956 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" downshifts 485940 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" promotor_-35 486053..486060 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486075..486094 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486082 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" misc_RNA 486092..486235 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" gene 486092..486235 /gene="swaO" /locus_tag="BSU_misc_RNA_7" downshifts 486233 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" S_feature 486278..486431 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 486432..488255 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" gene 486432..488255 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" downshifts 488247 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" CDS 488314..488763 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" gene 488314..488763 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" promotor_-35 488776..488782 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488797..488815 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488798 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" CDS 488830..490554 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" gene 488830..490554 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" S_feature complement(489666..490525) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(490527..490638) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 490538 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" CDS complement(490546..490749) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" gene complement(490546..490749) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" downshifts complement(490570) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" promotor_no_box complement(490598..490698) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 490607..490612 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490629..490647 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(490638) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" S_feature 490639..490854 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 490639 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" S_feature complement(490705..490776) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(490748) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" CDS complement(490777..491043) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" gene complement(490777..491043) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" promotor_-10 complement(491059..491078) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(491077) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" promotor_-35 complement(491090..491097) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(491147..492424) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" gene complement(491147..492424) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" downshifts complement(491166) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(492486..492505) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(492498) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" S_feature complement(492500..492577) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(492518..492525) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(492561..492580) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(492577) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" promotor_-35 complement(492594..492603) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(492654..492911) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" gene complement(492654..492911) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" downshifts complement(492662) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" downshifts complement(492728) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" CDS complement(492989..493441) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" gene complement(492989..493441) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" promotor_-10 complement(493460..493478) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(493477) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" promotor_-35 complement(493492..493498) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 493510 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" misc_feature 493518..493537 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 493559..494377 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" gene 493559..494377 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" downshifts 494368 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" promotor_-35 494445..494451 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 494465..494483 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 494473 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" CDS 494506..494877 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" gene 494506..494877 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" downshifts complement(494510) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" downshifts 494894 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" upshifts complement(494928) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(494931..494934) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 494956..494963 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 494975..494994 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 494982 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" CDS 495009..495350 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" gene 495009..495350 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" CDS 495344..495703 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" gene 495344..495703 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" S_feature complement(495406..495699) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 495644 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" downshifts 495688 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" CDS complement(495740..496561) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" gene complement(495740..496561) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" downshifts complement(495744) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" promotor_-10 complement(496583..496601) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(496604) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" promotor_-35 complement(496615..496621) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(496646..497698) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" gene complement(496646..497698) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" promotor_-35 496958..496965 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 496980..497767 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 496980..496999 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 496981 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" promotor_-10 complement(497711..497730) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(497716) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" promotor_-35 complement(497744..497751) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 497768..499375 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" gene 497768..499375 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" CDS 499365..500045 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" gene 499365..500045 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" S_feature 500046..500120 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 500087..500094 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500109..500126 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500122 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" CDS 500166..501431 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" gene 500166..501431 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" downshifts 501424 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" downshifts complement(501478) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" misc_feature 501515..501532 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 501517 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 501579..502631 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" gene 501579..502631 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" S_feature 502632..502875 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 502832 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" CDS 502908..503834 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" gene 502908..503834 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" CDS 503854..504594 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" gene 503854..504594 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" misc_feature 504653..504672 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 504658 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 504689..505024 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" gene 504689..505024 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" downshifts 504999 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" S_feature 505044..505113 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 505079..505086 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505100..505119 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505114 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" CDS 505152..506297 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" gene 505152..506297 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" downshifts 506279 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" CDS complement(506322..506501) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" gene complement(506322..506501) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" downshifts complement(506340) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" CDS complement(506455..506619) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" gene complement(506455..506619) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" S_feature complement(506502..506670) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(506662..506681) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(506672) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" promotor_-35 complement(506696..506703) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 506811..506816 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506832..506850 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506836 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" CDS 506866..507738 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" gene 506866..507738 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" promotor_-35 507102..507111 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 507124..507139 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 507127 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" S_feature complement(507683..507752) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(507726) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" S_feature 507739..508088 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(507753..508073) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" gene complement(507753..508073) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" promotor_-35 508069..508073 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508082..508096 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 508090..508247 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 508090 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" promotor_-10 complement(508094..508113) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(508109) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" promotor_-35 complement(508127..508134) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508248..509312 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" gene 508248..509312 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" downshifts 509300 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" CDS 509384..510757 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" gene 509384..510757 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" promotor_-35 510788..510794 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510808..510819 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 510818 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" misc_feature 510861..510880 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 510862..511036 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 510862 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" promotor_-35 511004..511011 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 511026..511045 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 511038..511105 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 511038 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" CDS 511157..512641 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" gene 511157..512641 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" downshifts 512634 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" S_feature 512754..512813 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 512754..512763 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 512756 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" promotor_-10 512775..512790 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 512814..513293 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " gene 512814..513293 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" CDS 513283..514764 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" gene 513283..514764 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" downshifts 514734 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" S_feature 514779..515106 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(514788) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" CDS complement(515016..515615) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" gene complement(515016..515615) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" promotor_-35 515076..515081 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 515094..515113 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 515108..515709 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 515108 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" misc_feature complement(515639..515658) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(515650) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" CDS 515710..516075 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" gene 515710..516075 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" promotor_-35 516078..516083 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 516099..516240 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 516099..516117 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 516099 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" CDS 516241..517257 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" gene 516241..517257 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" downshifts 517242 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" promotor_-35 517302..517309 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 517323..517342 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 517330 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 517372..518541 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" gene 517372..518541 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" promotor_-35 518470..518475 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 518490..518508 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 518496 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" promotor_-35 518571..518574 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 518590..518609 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 518591 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 518657..518938 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" gene 518657..518938 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" CDS 518943..519293 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" gene 518943..519293 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" S_feature complement(519083..519559) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(519126) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" downshifts 519273 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" promotor_-35 519327..519334 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519348..519367 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519356 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 519408..520232 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" gene 519408..520232 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" promotor_-10 complement(519542..519560) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(519559) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" S_feature complement(519561..520160) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(519574..519581) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(520149..520167) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(520160) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" S_feature complement(520162..520750) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(520181..520187) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 520237..520602 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" gene 520237..520602 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" CDS 520606..521007 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" gene 520606..521007 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" promotor_-10 complement(520748..520767) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(520765) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" promotor_-35 complement(520781..520790) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 521019..522026 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" gene 521019..522026 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" promotor_-35 522020..522026 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 522041..522059 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 522047 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 522088..522417 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" gene 522088..522417 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" CDS 522414..522896 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" gene 522414..522896 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" CDS 522862..523650 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" gene 522862..523650 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" CDS 523650..524249 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" gene 523650..524249 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" downshifts 524235 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" promotor_-35 524293..524299 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524314..524333 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524326 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 524360..524476 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" gene 524360..524476 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" CDS 524492..524785 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" gene 524492..524785 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" promotor_-35 524753..524761 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524773..524792 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 524782..525222 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" gene 524782..525222 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" upshifts 524788 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" S_feature complement(525021..528076) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 525206..525649 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" gene 525206..525649 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" downshifts 525624 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" promotor_-35 525680..525681 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 525697..525716 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 525697 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" CDS 525743..527902 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" gene 525743..527902 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" misc_feature 527890..527909 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 527912..528128 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 527912 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" CDS complement(527912..528025) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" gene complement(527912..528025) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" promotor_-10 complement(528065..528084) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528082) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" promotor_-35 complement(528099..528107) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 528129..528581 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" gene 528129..528581 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" promotor_-35 528587..528593 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528608..528627 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 528616..528703 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 528616 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" downshifts complement(528648) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" tRNA 528704..528778 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528704..528778 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" tRNA 528783..528873 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528783..528873 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" tRNA 528903..528974 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528903..528974 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" tRNA 528986..529060 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528986..529060 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" tRNA 529087..529162 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529087..529162 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" tRNA 529174..529255 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529174..529255 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" downshifts 529320 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" tRNA 529336..529422 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529336..529422 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" downshifts 529409 /Source="Nicolas_upshifts" /id="D229" /incds=0 /nref=82 /ntot=235 /MaxReadThrough="4.38481" /MaxDrop="5.23398" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=89 /isTUend="FALSE" S_feature 529454..530352 /Source="Nicolas_S_feature" /locus_tag="new_529454_530352" /HighExp="Cold, G180, G135, Paraq, Oxctl, C30, G150, H2O2, Fru, Lbexp" /AntisenseName="ydcL" /AntisenseCor="-0.23338643759911901" /AntisenseRegPval="-4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S169" downshifts complement(529477) /Source="Nicolas_upshifts" /id="D230" /incds=0 /nref=96 /ntot=231 /MaxReadThrough="2.93365" /MaxDrop="6.05127" /score="8.78044068" /energy="-9.2" /TU="U381" /idTUdmin="U381" /TUdmin="-125" /isTUend="FALSE" CDS complement(529505..530611) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22505685; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: integrase" /protein_id="NP_388361.1" /db_xref="EnsemblGenomes-Gn:BSU04800" /db_xref="EnsemblGenomes-Tr:CAB12287" /db_xref="GOA:P96629" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG12099" /db_xref="UniProtKB/Swiss-Prot:P96629" /translation="MSVKKLENGQYQVDVSFGFDPITGERIRTRPVASTRKEALELEA KLRREFQEERARKSRSVSFPTLISIYLASCEIDSKPNYYQNQKYIINKHISDYFLKSD IQKITHREITDFRKHLMETGLSNKSVNNIMTSLSKIFDTAVHEEILKRNPCDNVKRLP LTRKKMKFWRPEEFKKFISLIPQDQLLFKTFYTVAFLTGLRCGEMLALQWKDIDKILL EIDVHKSCTWLDGQFVVTTPKTKNSIRRVSINKKLLKLLERWKEAQEELFNELGIRHS HDTYIFQYKDTPSRKDIFSRKIKYFCKDSDLTPIRLHDFRHSHVALLIHQGEDYITIK ERLGHGSVKTTIDVYGHLYPNKQKEMADKLDDLL*" gene complement(529505..530611) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" CDS complement(530624..531133) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:18761623, 21036995, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18761623, 21036995, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: site-specific protease cleaving ImmR" /protein_id="NP_388362.1" /db_xref="EnsemblGenomes-Gn:BSU04810" /db_xref="EnsemblGenomes-Tr:CAB12288" /db_xref="GOA:P96630" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG12100" /db_xref="UniProtKB/Swiss-Prot:P96630" /translation="MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQ ANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKL EHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRI YSHEISAFG*" gene complement(530624..531133) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" downshifts complement(530936) /Source="Nicolas_upshifts" /id="D231" /incds=1 /nref=12 /ntot=39 /MaxReadThrough="6.14325" /MaxDrop="3.22989" /score="17.0287275" /energy="-11.8" /TU="U381" /idTUdmin="U384" /TUdmin=1518 /isTUend="FALSE" CDS complement(531130..531513) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8083175, 17511812, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 17511812, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: transcriptional regulator(Xre family)" /protein_id="NP_388363.1" /db_xref="EnsemblGenomes-Gn:BSU04820" /db_xref="EnsemblGenomes-Tr:CAB12289" /db_xref="GOA:P96631" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG12101" /db_xref="UniProtKB/Swiss-Prot:P96631" /translation="MSLGKRLKEARQKAGYTQKEAAEKLNIGNNNLSNYERDYRDPDT DTLLKLSNLYNVSTDYLLGKDEVSKKNETDLLNKTINEAIQELKDEDTLLFMNDGEFD EETARLVKKALKNGIKFIDELKKKE*" gene complement(531130..531513) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" promotor_-10 complement(531542..531561) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531554) /Source="Nicolas_upshifts" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" promotor_-35 complement(531576..531583) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 531713..531720 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-35" promotor_-10 531735..531754 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-10" upshifts 531740 /Source="Nicolas_upshifts" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" CDS 531787..531981 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3269394, 17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3269394, 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: excisionase" /protein_id="NP_388364.1" /db_xref="EnsemblGenomes-Gn:BSU04830" /db_xref="EnsemblGenomes-Tr:CAB12290" /db_xref="GOA:O31490" /db_xref="SubtiList:BG12670" /db_xref="UniProtKB/Swiss-Prot:O31490" /translation="MKGEFLTARDIQKILGVKQAKSYDIIRTLNAQMKEEGYMVIQGK VSRAKFEECYCYKGPKSQTG*" gene 531787..531981 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" CDS 531978..532238 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="YP_003097681.1" /db_xref="EnsemblGenomes-Gn:BSU04839" /db_xref="EnsemblGenomes-Tr:CAX52552" /db_xref="UniProtKB/Swiss-Prot:C0H3V5" /translation="MIFINIDITNSFMKEAVPLARQMEGDWIARMKIALNSVIINHYL NLPLTIENVNELLRKGVSYRRICKHYGIGRKDIEKLRQSSVV*" gene 531978..532238 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" CDS 532292..532552 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388365.1" /db_xref="EnsemblGenomes-Gn:BSU04840" /db_xref="EnsemblGenomes-Tr:CAB12291" /db_xref="SubtiList:BG12102" /db_xref="UniProtKB/Swiss-Prot:P96632" /translation="MKIRVNATIITDVEALKADKDLNHFKDYATCETFVVDADNHLKA NEEISELLKGWDWWCIWSTRPLSKKDNQVFTLYNDDLYNLCR*" gene 532292..532552 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" S_feature complement(532412..532652) /Source="Nicolas_S_feature" /locus_tag="new_532412_532652_c" /HighExp="T5.0H, T4.0H, T3.0H, Lbstat, T3.30H, T2.0H, Cold, Gly, S2, T2.30H" /AntisenseName="ydcO" /AntisenseCor="0.131178357364787" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S170" promotor_-35 532578..532585 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(532583..532642) /gene="sncO" /locus_tag="BSU_misc_RNA_65" /product="ICEBs1 mobile element: conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796, 22505685; Product type n: RNA" gene complement(532583..532642) /gene="sncO" /locus_tag="BSU_misc_RNA_65" promotor_-10 532600..532619 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 532604..532921 /Source="Nicolas_S_feature" /locus_tag="new_532604_532921" /HighExp="T0.30H, T0.0H, T1.0H, T1.30H, T-0.40H, T2.0H, HiOs, T2.30H, MG 120, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S171" upshifts 532604 /Source="Nicolas_upshifts" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" promotor_-10 complement(532637..532656) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532652) /Source="Nicolas_upshifts" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" promotor_-35 complement(532670..532677) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532758..532886 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 22505685" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: hypothetical protein" /protein_id="YP_009513947.1" /translation="MMAIISLLGCHEGVKPLATDKRQDGYRTGANQKHKIEINVLL*" gene 532758..532886 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" CDS 532922..533302 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" /experiment="publication(s) with functional evidences, PMID:22505685, 23326247, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 23326247, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: helicase processivity factor" /protein_id="NP_388366.1" /db_xref="EnsemblGenomes-Gn:BSU04850" /db_xref="EnsemblGenomes-Tr:CAB12292" /db_xref="InterPro:IPR010365" /db_xref="SubtiList:BG12103" /db_xref="UniProtKB/Swiss-Prot:P96633" /translation="MNLNFIVPDINMTFGDMKFMGLNRERYVYDRENNKRTDVLESRI YNIASAVQGGQIEVTIPEYAGAKEIPPFADIELKNPKISAMATSQRDSTYANVMWKLE ADDIVVKGGSSVKPAAATGGNEKK*" gene 532922..533302 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" CDS 533338..534780 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" /experiment="publication(s) with functional evidences, PMID:17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: coupling conjugation protein VirD4" /protein_id="NP_388367.1" /db_xref="EnsemblGenomes-Gn:BSU04860" /db_xref="EnsemblGenomes-Tr:CAB12293" /db_xref="GOA:P96634" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12104" /db_xref="UniProtKB/Swiss-Prot:P96634" /translation="MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLF WREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQK IAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRF QNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMK HISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLP KKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAF MDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGL MSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALV GVEGAQATAVASGSVSDQTASGEGVSEANG*" gene 533338..534780 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" CDS 534773..535831 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" /experiment="publication(s) with functional evidences, PMID:17511812, 17693500, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 17693500, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: DNA relaxase" /protein_id="NP_388368.1" /db_xref="EnsemblGenomes-Gn:BSU04870" /db_xref="EnsemblGenomes-Tr:CAB12294" /db_xref="GOA:P96635" /db_xref="InterPro:IPR003491" /db_xref="SubtiList:BG12105" /db_xref="UniProtKB/Swiss-Prot:P96635" /translation="MDELKQPPHANRGVVIVKEKNEAVESPLVSMVDYIRVSFKTHDV DRIIEEVLHLSKDFMTEKQSGFYGYVGTYELDYIKVFYSAPDDNRGVLIEMSGQGCRQ FESFLECRKKTWYDFFQDCMQQGGSFTRFDLAIDDKKTYFSIPELLKKAQKGECISRF RKSDFNGSFDLSDGITGGTTIYFGSKKSEAYLCFYEKNYEQAEKYNIPLEELGDWNRY ELRLKNERAQVAIDALLKTKDLTLIAMQIINNYVRFVDADENITREHWKTSLFWSDFI GDVGRLPLYVKPQKDFYQKSRNWLRNSCAPTMKMVLEADEHLGKTDLSDMIAEAELAD KHKKMLDVYMADVADMVV*" gene 534773..535831 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" downshifts 534776 /Source="Nicolas_upshifts" /id="D232" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="5.48512" /MaxDrop="3.25403" /score="-9.5933493" /energy="-23.1" /TU="U382,U383" /idTUdmin="U382" /TUdmin="-176" /isTUend="FALSE" S_feature 535832..536095 /Source="Nicolas_S_feature" /locus_tag="new_535832_536095" /HighExp="T0.30H, T1.0H, T1.30H, T0.0H, T2.0H, T2.30H, T-0.40H, T3.0H, T3.30H, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigA" /TUlongPSig=1 /label="S172" CDS 536096..536365 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388369.1" /db_xref="EnsemblGenomes-Gn:BSU04880" /db_xref="EnsemblGenomes-Tr:CAB12295" /db_xref="SubtiList:BG12106" /db_xref="UniProtKB/Swiss-Prot:P96636" /translation="MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAE RFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE*" gene 536096..536365 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" promotor_-10 complement(536156..536175) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(536172) /Source="Nicolas_upshifts" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(536190..536197) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 536404..536670 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388370.1" /db_xref="EnsemblGenomes-Gn:BSU04890" /db_xref="EnsemblGenomes-Tr:CAB12296" /db_xref="SubtiList:BG12107" /db_xref="UniProtKB/Swiss-Prot:P96637" /translation="MFNINLLNQARLESDLDSLGCLDIAEELIEKMMEDVFYSDVAQR IIVQTLAVINNANAKLQATFNILEDEDMETDERSVEFEGISYYE*" gene 536404..536670 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" CDS 536687..536995 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388371.1" /db_xref="EnsemblGenomes-Gn:BSU04900" /db_xref="EnsemblGenomes-Tr:CAB12297" /db_xref="SubtiList:BG12108" /db_xref="UniProtKB/Swiss-Prot:P96638" /translation="MSAVDKRFKSLGFNVGIPSLVFVRSLSRDCMLVVEGERVKGFAE YRYTFYKTRYLPDGRMTSLKVYMENQSIKRVLHRVASFLSFLERTKQIEQKECEKVAQ *" gene 536687..536995 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" CDS 536985..538049 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery VirB8" /protein_id="NP_388372.1" /db_xref="EnsemblGenomes-Gn:BSU04910" /db_xref="EnsemblGenomes-Tr:CAB12298" /db_xref="GOA:O31491" /db_xref="InterPro:IPR024735" /db_xref="InterPro:IPR035628" /db_xref="SubtiList:BG12109" /db_xref="UniProtKB/Swiss-Prot:O31491" /translation="MLNKEIGSDKKEESFFRSAFQKLKRIERPEKDKQKVPRDRSKLI AVTLWSCVGSLLFICLLAVLLSINTRSQLNDMKDETNKPTNDDKQKISVTAAENFLSG FINEYMNVKNDQESIEKRMQSLESYMVKQEDNHFEDEERFNVDGLKGDRELKGYSLYN VKEGDKNSLFQYKVTYENLYPVEKEVEKEVKDGKKKKKVKEKVKTNEKYEKQMLLNIP VTNKGDSFAVSAVPYFTQIYDLKGDIAFKGKEETRDEYAGEKKESIESFLQNFFEKYA SEKKEEMVYMMKKPEALEGNLLFGEVQSVKIFETKKGFEVFCAVRFKEKENDIPVNEK FSLEITENSGQFYVNKLKHQ*" gene 536985..538049 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" misc_feature 537523..537530 /Source="Nicolas_upshift_promotors" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 537526 /Source="Nicolas_upshifts" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" downshifts 537614 /Source="Nicolas_upshifts" /id="D233" /incds=1 /nref=1 /ntot=15 /MaxReadThrough="6.32422" /MaxDrop="3.45679" /score="-2.67923628" /energy="-7.8" /TU="U383,U386" /idTUdmin="U382" /TUdmin=2662 /isTUend="FALSE" CDS 538061..538309 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388373.1" /db_xref="EnsemblGenomes-Gn:BSU04920" /db_xref="EnsemblGenomes-Tr:CAB12299" /db_xref="GOA:P96640" /db_xref="SubtiList:BG12110" /db_xref="UniProtKB/Swiss-Prot:P96640" /translation="MDFMNFFILGADLPTLGGVKGWASDVVIQFITIVVMFIAAKNLM KLKMGGIIFVCCIGSAVTWVIKHWSEFSGWINALMEKL*" gene 538061..538309 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" CDS 538322..538846 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388374.1" /db_xref="EnsemblGenomes-Gn:BSU04930" /db_xref="EnsemblGenomes-Tr:CAB12300" /db_xref="GOA:P96641" /db_xref="InterPro:IPR025608" /db_xref="SubtiList:BG12111" /db_xref="UniProtKB/Swiss-Prot:P96641" /translation="MGRLVFNYRKAMREPKKIQQLTENYSLPFAVELIPAINYFIFVG LCFGFWYGVRMIFPHAFDNSYVIVIFGIPFFLTMLVTKIKPEGKNIYIYFFDFAKYYF FIKLPQKKYCNDRKIDLSNEKQIEFRKLVKVVDYSNETKNAYEGNTQEFAVNKNGRRV GVLPNKKQFDSYAK*" gene 538322..538846 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" CDS 538734..541229 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" /experiment="publication(s) with functional evidences, PMID:19734305, 19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19734305, 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB4-like ATPase" /protein_id="NP_388375.3" /db_xref="EnsemblGenomes-Gn:BSU04940" /db_xref="EnsemblGenomes-Tr:CAB12301" /db_xref="GOA:P96642" /db_xref="InterPro:IPR016628" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12112" /db_xref="UniProtKB/Swiss-Prot:P96642" /translation="MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESY KKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLL EQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSF FEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITN TIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQT ESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMN WLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDK NWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPF LANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQ RVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFE QVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNE VVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFA LGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTK DALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGR TSKISIECLFEEWQGALKTVEKKAVAYAEEKYL*" gene 538734..541229 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" CDS 541248..541574 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19943900, 22505685, 26013486; Producttype h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388376.1" /db_xref="EnsemblGenomes-Gn:BSU04950" /db_xref="EnsemblGenomes-Tr:CAB12302" /db_xref="InterPro:IPR015055" /db_xref="SubtiList:BG12113" /db_xref="UniProtKB/Swiss-Prot:P96643" /translation="MEIAFLNSLVVTSPGFYKAEKITLDEVKQWLKHYDGRYKSFIGH KSTAQFLQKLLGIRIEQNRKTFRHMKYQKAICFSLYERYPENVLLTQRDLEKARYQFY LLTRLD*" gene 541248..541574 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" CDS 541578..544025 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" /experiment="publication(s) with functional evidences, PMID:19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB6 subunit of the conjugation machinery" /protein_id="NP_388377.1" /db_xref="EnsemblGenomes-Gn:BSU04960" /db_xref="EnsemblGenomes-Tr:CAB12303" /db_xref="GOA:P96644" /db_xref="InterPro:IPR000515" /db_xref="SubtiList:BG12114" /db_xref="UniProtKB/Swiss-Prot:P96644" /translation="MVVMKKKRILIVSAIVLLFLTVASAVTVFSADGDTTTQPKVEKA GGVELKVKRFPISRYQANNEASDDLIKGAFVGLTNVTFSFAGNIVRVVDTGMDILYNL QPIDEFANSITNVSKTVYKTLKKNFGEALFIFTCAYVVYLFCVRGSVKEAMRRSILFI CVMVIGGLWMSNAGYYMKVLNALSVEAQGKLLTAGNGLVGIVQDEGNFADSSAIEKGK EMEGTVAVMRNLYFDIALMKPFLIVNFDETSEKKINEEDTDKGGLNRIDKLLSYKLSE DGEKDKKDYIKETEIDDYKNESMTSGNVFNQLGESFIAVVASIVIGIPFLALAFFNFL LQVVALVIVFFVPFAFILAYVPQLAYSGFVTLGRLGSVYLLKAMLGVIVLFVYVTCFI VDKLIPPNGFGMYLLNVAVLASILWIGFHKRDAIIKFVTAGKVVSVDNNMMENMRQNI VQPAWEQAKKIGGVWGNGGGVFTDFTKHFGGRKDGSNADGVTGAPSGGGNSPSGTAMG YDNTHAISRTPQKETANGIANHNSRSLKRNPQTLSKEQEKQKQKEAFANAKENKQQSH LARLRKDGINSPMLKDALNEGNEDLSKRAPILQDKKDESARTDQKEYVEQLLKQPNNQ QQTDDASLQHEEESTSNRAPVLQENEKDTERTDQKAYIYDEQNQNLETDQQQDFEVQK DDSVSNSEPVAQEKTAEIKRSDQKVMMNQPEPQLGFESPQSTKVENQPIANNERKIRP SEPAKVHSDGIRVDEKQAVAPAENKTVSREKQPSSQTIKRTEQSVNSFDQVSLNEIAR RSSSKVEDRLRRDERTR*" gene 541578..544025 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" CDS 544022..545011 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" /experiment="publication(s) with functional evidences, PMID:18305117, 22505685, 24532767, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18305117, 22505685, 24532767, 26013486; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: two-domain autolysin withN-acetylmuramidase and DL-endopeptidase activity VirB1" /protein_id="NP_388378.1" /db_xref="EnsemblGenomes-Gn:BSU04970" /db_xref="EnsemblGenomes-Tr:CAB12304" /db_xref="GOA:P96645" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG12115" /db_xref="UniProtKB/Swiss-Prot:P96645" /translation="MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGG DGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESI GLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTK KLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALK YEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDL VFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK*" gene 544022..545011 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" CDS 545026..545532 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388379.1" /db_xref="EnsemblGenomes-Gn:BSU04980" /db_xref="EnsemblGenomes-Tr:CAB12305" /db_xref="GOA:P96646" /db_xref="SubtiList:BG12116" /db_xref="UniProtKB/Swiss-Prot:P96646" /translation="MKTHIAWASACLLLVMLTGFFTIGQQTYKIEKLKDKNEVLSEKI KELNHIESTSSASENKAFFEAFFNYSDIDIRYETVKKHTTGKGFDYAFPSRSDQKHTV SVQSELLSLESYSKPLDESHELFLNIVEVATTANSVTTNQVLIVQTTMKKEKDGWLVD NVQVKGNG*" gene 545026..545532 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" promotor_-35 545535..545541 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 545555..545574 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 545564 /Source="Nicolas_upshifts" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" CDS 545595..545975 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative lipoprotein of unknown function" /protein_id="NP_388380.1" /db_xref="EnsemblGenomes-Gn:BSU04990" /db_xref="EnsemblGenomes-Tr:CAB12306" /db_xref="InterPro:IPR028075" /db_xref="SubtiList:BG12117" /db_xref="UniProtKB/Swiss-Prot:P96647" /translation="MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTE INIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGEN DRLGLSKKTPDYEEVKGEETELEE*" gene 545595..545975 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" downshifts 545952 /Source="Nicolas_upshifts" /id="D234" /incds=0 /nref=167 /ntot=245 /MaxReadThrough="2.07932" /MaxDrop="5.51482" /score="8.08816145" /energy="-14.7" /TU="NA" /idTUdmin="U383" /TUdmin=0 /isTUend="TRUE" downshifts complement(546028) /Source="Nicolas_upshifts" /id="D235" /incds=0 /nref=51 /ntot=228 /MaxReadThrough="3.21157" /MaxDrop="4.80215" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-110" /isTUend="FALSE" S_feature complement(546051..546165) /Source="Nicolas_S_feature" /locus_tag="new_546051_546165_c" /HighExp="LPhT, Lbtran, Mt0, HiTm, Lbexp, M40t45, M0t45, HPh, dia0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S173" downshifts complement(546094) /Source="Nicolas_upshifts" /id="D236" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="5.69722" /MaxDrop="4.64006" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-176" /isTUend="FALSE" CDS complement(546166..546966) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388381.1" /db_xref="EnsemblGenomes-Gn:BSU05000" /db_xref="EnsemblGenomes-Tr:CAB12307" /db_xref="GOA:P96648" /db_xref="InterPro:IPR000157" /db_xref="InterPro:IPR035897" /db_xref="SubtiList:BG12118" /db_xref="UniProtKB/Swiss-Prot:P96648" /translation="MDTLKKLKFEANGIIGVLLDYSREPVLTNIIDQFRTSLESNDIE LIRYSLEQLKTWYARNRNEIYKNEFVFNEFEHHETENKIKKFLDELPVVDETEKSSIT HFSSDQNRELEKKIFISHSSKDKIVCNAFVELLEDIGVSSEDIIYTSSPYHGIPGDED IFEYLKKHLFKGAYVFYMLSDNYYDSVYCLNEMGATWVNSNNCSTFILPGFKGEIKGV IDKNKKAFSLEEPIDLFNLKEKILRMYDLTLEDKKWERIKAKFNTKLK*" gene complement(546166..546966) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" promotor_-10 complement(547011..547030) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(547029) /Source="Nicolas_upshifts" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" promotor_-35 complement(547046..547049) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-35" CDS 547306..548481 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" /EC_number="3.1.-.-" /experiment="publication(s) with functional evidences, PMID:16105942, 22505685, 23526881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16105942, 22505685, 23526881; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: response regulator aspartate phosphatase" /protein_id="NP_388382.1" /db_xref="EnsemblGenomes-Gn:BSU05010" /db_xref="EnsemblGenomes-Tr:CAB12308" /db_xref="GOA:P96649" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4I1A" /db_xref="SubtiList:BG12119" /db_xref="UniProtKB/Swiss-Prot:P96649" /translation="MRGVFLDKDKIPYDLVTKKLNEWYTSIKNDQVEQAEIIKTEVEK ELLNMEENQDALLYYQLLEFRHEIMLSYMKSKEIEDLNNAYETIKEIEKQGQLTGMLE YYFYFFKGMYEFRRKELISAISAYRIAESKLSEVEDEIEKAEFFFKVSYVYYYMKQTY FSMNYANRALKIFREYEEYAVQTVRCQFIVAGNLIDSLEYERALEQFLKSLEISKESN IEHLIAMSHMNIGICYDELKEYKKASQHLILALEIFEKSKHSFLTKTLFTLTYVEAKQ QNYNVALIYFRKGRFIADKSDDKEYSAKFKILEGLFFSDGETQLIKNAFSYLASRKMF ADVENFSIEVADYFHEQGNLMLSNEYYRMSIEARRKIKKGEIIDENQPDSIGSSDFK* " gene 547306..548481 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" promotor_-35 548161..548168 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548182..548200 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548192 /Source="Nicolas_upshifts" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" promotor_-35 548389..548395 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 548394 /Source="Nicolas_upshifts" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" promotor_-10 548410..548421 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 548438..548557 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200, 21908671, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 21908671, 22505685; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: secreted regulator of theactivity of phosphatase RapI" /protein_id="NP_388383.1" /db_xref="EnsemblGenomes-Gn:BSU05020" /db_xref="EnsemblGenomes-Tr:CAB12309" /db_xref="SubtiList:BG12645" /db_xref="UniProtKB/Swiss-Prot:O31492" /translation="MKISRILLAAVILSSVFSITYLQSDHNTEIKVAADRVGA*" gene 548438..548557 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" downshifts 548555 /Source="Nicolas_upshifts" /id="D237" /incds=0 /nref=46 /ntot=227 /MaxReadThrough="4.14733" /MaxDrop="5.8523" /score="15.7846721" /energy="-10.4" /TU="U389" /idTUdmin="U390" /TUdmin="-15" /isTUend="TRUE" CDS 548710..549651 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative helicase" /protein_id="NP_388384.1" /db_xref="EnsemblGenomes-Gn:BSU05030" /db_xref="EnsemblGenomes-Tr:CAB12310" /db_xref="GOA:P96650" /db_xref="SubtiList:BG12120" /db_xref="UniProtKB/Swiss-Prot:P96650" /translation="MGENMFKKEKVTEYIWTILIPTIITFIISWVGSYYNGTSTVSIG QPTKVSGQYITPINISPYHDIKELRITFPQKLDVKQISSNEPINVKSDKNNIGVESNS TFEIAKIVENNSVQLLITTQKKLNDKEIRIDKNGNNISVNYESQIVNPAKKQLINLII TSSIYFIMLNILALIMNKRWDKYYAKMKNEIKEFEDNAKDLDKKSKKKSEELSELRKT LNQAFEETDRIKYHEKKKQILLLAKLNDYKKELTFWRNTIRKVLYELPDGDKKADKLI GTVTSSLKTYGTVEKNEHDYESLKVAAALLNDSDKRS*" gene 548710..549651 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" S_feature 549652..549910 /Source="Nicolas_S_feature" /locus_tag="new_549652_549910" /HighExp="HPh, S1, Gly, LoTm, LPh, MG 120, GM-0.1, aero, S2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80510899999999996" /TUshortSig="SigD" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S174" S_feature complement(549923..550239) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S175" downshifts 549952 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" downshifts complement(549984) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" CDS complement(550240..551259) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" gene complement(550240..551259) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" promotor_-10 complement(550935..550954) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550948) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" promotor_-35 complement(550969..550976) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 551048..551052 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 551069..551088 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 551073 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" S_feature 551074..551518 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 551519..551929 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" gene 551519..551929 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" S_feature 551930..551999 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 551956 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" CDS complement(552052..552501) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" gene complement(552052..552501) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" CDS 552616..553158 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" gene 552616..553158 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" promotor_-35 553631..553635 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 553652..553671 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 553661 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" CDS 553711..554475 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" gene 553711..554475 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" CDS 554669..555979 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" gene 554669..555979 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" S_feature 556002..556561 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 556562..556738 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" gene 556562..556738 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" CDS 556763..557449 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" gene 556763..557449 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" promotor_-35 557791..557795 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 557810..557829 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 557818 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" CDS 557873..558058 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" gene 557873..558058 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" downshifts 558057 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" CDS 558408..559001 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" gene 558408..559001 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" promotor_-35 559114..559121 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559135..559154 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559146..559263 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 559146 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" downshifts complement(559181) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" CDS 559264..559464 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" gene 559264..559464 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" S_feature complement(559362..560150) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 559367 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" downshifts 559468 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" misc_RNA complement(559532..559610) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(559532..559610) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" CDS complement(560151..560612) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" gene complement(560151..560612) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" S_feature 560621..561166 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(560664) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" promotor_-10 complement(560671..560690) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(560706..560713) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 561133 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" CDS complement(561180..561416) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" gene complement(561180..561416) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" CDS complement(561514..562389) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" gene complement(561514..562389) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" CDS 562502..563461 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" gene 562502..563461 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" upshifts complement(562523) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" misc_feature complement(562527..562546) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(563614..564486) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" gene complement(563614..564486) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" promotor_-10 complement(564579..564584) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(564586..564587) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(564591) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 564660..564666 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 564674 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" promotor_-10 564680..564699 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 564713..566101 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" gene 564713..566101 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" downshifts 566077 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" CDS 566211..567503 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" gene 566211..567503 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" promotor_-35 567512..567518 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567533..567552 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567540 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" S_feature 567551..567661 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 567662..568108 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" gene 567662..568108 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" downshifts 568137 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" promotor_-35 568188..568195 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 568210..568229 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 568211 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" CDS 568345..568938 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" gene 568345..568938 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" downshifts 568981 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" downshifts complement(569057) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" promotor_-35 569070..569077 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 569091 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 569092..569111 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(569290..569949) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" gene complement(569290..569949) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" promotor_-10 complement(569998..570017) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570005) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" promotor_-35 complement(570029..570034) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(570371..571234) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" gene complement(570371..571234) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" promotor_-35 571277..571283 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 571298..571317 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(571299..571318) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 571313 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(571323) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(571333..571340) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 571389..572780 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" gene 571389..572780 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" promotor_-35 572908..572915 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 572926..572945 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 572940 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" CDS 572974..573399 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" gene 572974..573399 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" S_feature 573400..574654 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(573452..574024) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" gene complement(573452..574024) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" downshifts complement(573457) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" S_feature complement(574025..574105) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(574106..574435) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" gene complement(574106..574435) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" misc_feature complement(574452..574471) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(574469) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" misc_feature 574643..574662 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 574656 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" CDS 574690..575562 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" gene 574690..575562 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" downshifts 575449 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" downshifts 575647 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" CDS complement(575712..576098) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" gene complement(575712..576098) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" downshifts complement(575724) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" S_feature complement(576099..576163) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 576151..576158 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(576152..576171) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576165) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" promotor_-10 576172..576191 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576175 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" promotor_-35 complement(576186..576193) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 576209..576802 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" gene 576209..576802 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" CDS complement(576946..578133) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" gene complement(576946..578133) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" promotor_-35 578269..578273 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578287 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" promotor_-10 578288..578307 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 578337..578933 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" gene 578337..578933 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" CDS 579047..579232 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" gene 579047..579232 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" downshifts 579211 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" promotor_-35 579344..579347 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 579354..579540 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 579354 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" promotor_-10 579362..579381 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 579541..579876 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" gene 579541..579876 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" CDS 579889..581196 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" gene 579889..581196 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" CDS 581228..581332 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" gene 581228..581332 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo CDS 581341..581454 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" gene 581341..581454 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo promotor_-35 581640..581648 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 581659..581677 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581676 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 581694..582479 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" gene 581694..582479 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" downshifts 581741 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" downshifts 582489 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" CDS complement(582536..583456) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" gene complement(582536..583456) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" CDS 583589..585037 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" gene 583589..585037 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" CDS complement(585155..585778) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" gene complement(585155..585778) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" promotor_-10 complement(585802..585821) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 585810..585817 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(585821) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" promotor_-10 585832..585851 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585834 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" promotor_-35 complement(585836..585842) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 585868..586548 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" gene 585868..586548 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" downshifts 586581 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" CDS complement(586628..587071) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" gene complement(586628..587071) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" downshifts complement(586633) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(587094..587113) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587118) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" promotor_-35 complement(587127..587134) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(587157..587336) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" gene complement(587157..587336) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" CDS complement(587333..587476) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" gene complement(587333..587476) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" promotor_-35 587427..587429 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587445..587464 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587461 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 587744..588967 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" gene 587744..588967 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" CDS 588960..589601 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" gene 588960..589601 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" downshifts 589595 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(589628..589647) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(589649) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(589661..589668) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 589709..589714 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 589717..591891 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" gene 589717..591891 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" upshifts 589727 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" promotor_-10 589729..589747 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(590793..590811) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(590793) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(591895..592302) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 591912..591916 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 591926 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 591929..591948 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(591940) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" CDS complement(592303..593205) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" gene complement(592303..593205) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" S_feature complement(593206..593301) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(593281..593300) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(593301) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" promotor_-35 complement(593314..593321) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(593407..594096) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" gene complement(593407..594096) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" CDS complement(594186..594998) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" gene complement(594186..594998) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" promotor_-10 complement(595027..595046) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595040) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" promotor_-35 complement(595062..595069) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(595109..596002) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" gene complement(595109..596002) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" downshifts complement(595129) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" S_feature complement(596003..596095) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(596076..596095) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(596093) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" promotor_-35 complement(596111..596118) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 596284..596291 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596306..596325 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 596312 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" CDS 596478..597098 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" gene 596478..597098 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" promotor_-35 596822..596828 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 596833 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" promotor_-10 596842..596860 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 597114..598052 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" gene 597114..598052 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" promotor_-35 598040..598043 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598058..598077 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 598065..598153 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 598065 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" CDS 598154..598543 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" gene 598154..598543 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" downshifts 598534 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" misc_feature 598657..598676 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 598659..598728 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 598659 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" CDS 598729..599067 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" gene 598729..599067 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" downshifts 599055 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" CDS complement(599107..599343) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" gene complement(599107..599343) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" downshifts complement(599131) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" promotor_-35 599155..599161 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599176..599187 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599187 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(599344..599505) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(599509..599874) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(599549) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" CDS complement(599875..600105) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" gene complement(599875..600105) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" downshifts 600089 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" promotor_-10 complement(600126..600145) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600143) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" S_feature complement(600145..600228) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(600159..600168) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(600229..600906) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" gene complement(600229..600906) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" promotor_-10 complement(600877..600888) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600891) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(600903..600909) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(600907..601740) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 600922..600927 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 600942..600953 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 600947 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" CDS 601019..601726 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" gene 601019..601726 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" CDS complement(601741..602172) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" gene complement(601741..602172) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" CDS complement(602185..602427) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" gene complement(602185..602427) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" CDS complement(602441..602713) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" gene complement(602441..602713) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" promotor_-10 complement(602735..602754) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(602739) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(602768..602777) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 602932..602939 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602955..602974 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 602963 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" CDS 603012..603599 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" gene 603012..603599 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" CDS 603596..603940 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" gene 603596..603940 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" S_feature 603941..604102 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 604103..604576 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" gene 604103..604576 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" S_feature 604577..605269 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(604719) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" CDS complement(604736..606379) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" gene complement(604736..606379) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" S_feature complement(606414..606611) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 606428..606430 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606447..606465 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606451 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(606457) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" downshifts 606577 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(606603..606622) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(606615) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" promotor_-35 complement(606635..606642) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(606698) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" CDS complement(606699..608075) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" gene complement(606699..608075) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" misc_feature complement(608125..608144) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(608140) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" CDS complement(608246..608764) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" gene complement(608246..608764) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" downshifts complement(608260) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(608790..608809) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608809) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" promotor_-35 complement(608825..608828) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 608846..608853 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 608868..608887 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 608886 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" CDS 608933..609391 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" gene 608933..609391 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" CDS 609388..612045 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" gene 609388..612045 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" downshifts 612166 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" CDS complement(612191..612820) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" gene complement(612191..612820) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" downshifts complement(612195) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" CDS complement(612836..613330) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" gene complement(612836..613330) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" promotor_-10 complement(613322..613341) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(613337) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" promotor_-35 complement(613357..613362) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 613528..613530 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 613546..613565 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 613552..613640 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 613552 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" CDS 613641..614849 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" gene 613641..614849 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" downshifts 614828 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" CDS complement(614885..615622) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" gene complement(614885..615622) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" S_feature complement(615623..615761) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(615749..615768) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(615761) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" promotor_-35 complement(615782..615789) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 615793..615800 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 615814..615833 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 615818 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" CDS 615871..616545 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" gene 615871..616545 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" promotor_-35 616604..616609 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616625..616643 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 616631 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" CDS 616672..617934 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" gene 616672..617934 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" downshifts 617908 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" promotor_-35 618006..618013 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 618027..618046 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 618031 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" CDS 618095..619282 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" gene 618095..619282 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" downshifts 619294 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" CDS complement(619321..620031) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" gene complement(619321..620031) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" downshifts complement(619347) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" CDS complement(620097..621485) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" gene complement(620097..621485) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" promotor_-10 complement(621542..621559) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(621543) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" S_feature complement(621545..621613) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(621566..621573) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(621603..621621) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(621621) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" promotor_-35 complement(621637..621642) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 621690..621697 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621711..621730 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621713..621846 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 621713 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" CDS 621847..622218 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" gene 621847..622218 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" downshifts 622197 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" downshifts complement(622292) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" CDS complement(622293..622790) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" gene complement(622293..622790) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" CDS complement(622808..623290) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" gene complement(622808..623290) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" promotor_-35 622963..622970 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622984..623003 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622988 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(623319..623338) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(623329) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" promotor_-35 complement(623353..623356) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 623373..624350 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" gene 623373..624350 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" downshifts 624330 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" promotor_-35 624377..624383 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 624398..624416 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 624406 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-35 624442..624449 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 624462 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-10 624463..624482 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 624492..625109 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" gene 624492..625109 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" downshifts 625096 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" CDS complement(625125..626291) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" gene complement(625125..626291) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" downshifts complement(625154) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(626346..626446) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" gene complement(626346..626446) /gene="aswA" /locus_tag="BSU_misc_RNA_8" downshifts complement(626387) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" promotor_-10 complement(626456..626475) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(626470) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" promotor_-35 complement(626491..626495) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 626554..626561 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 626575..626594 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 626582 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 626622..626933 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" gene 626622..626933 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" CDS 626933..627265 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" gene 626933..627265 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" CDS 627284..628612 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" gene 627284..628612 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" CDS 628630..630027 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" gene 628630..630027 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" S_feature 630028..630114 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 630092..630099 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 630113..630132 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 630116 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 630170..630883 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" gene 630170..630883 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" CDS 630912..631811 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" gene 630912..631811 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" CDS 631808..632755 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" gene 631808..632755 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" CDS 632774..633862 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" gene 632774..633862 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" downshifts 633856 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" CDS complement(633923..634651) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" gene complement(633923..634651) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo downshifts complement(633973) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" CDS complement(634582..634776) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" gene complement(634582..634776) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo promotor_-10 complement(634809..634820) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(634817) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" promotor_-35 complement(634834..634840) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 634895..634902 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 634916..634935 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 634918..635018 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 634920 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" downshifts complement(634966) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" upshifts 634978 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" promotor_-35 634986..634993 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 635007..635026 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 635022..635109 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 635022 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" tRNA 635110..635186 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635110..635186 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" tRNA 635200..635273 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635200..635273 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" rRNA 635433..636987 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635433..636987 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" rRNA 637155..640082 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 637155..640082 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" rRNA 640138..640254 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640138..640254 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" tRNA 640268..640344 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640268..640344 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" tRNA 640405..640481 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640405..640481 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" downshifts 640478 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" promotor_-35 640582..640586 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640602..640621 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640606 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" CDS 640662..641639 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" gene 640662..641639 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" CDS 641654..642130 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" gene 641654..642130 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" CDS 642111..642800 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" gene 642111..642800 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" CDS 642810..643265 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" gene 642810..643265 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" CDS 643258..644298 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" gene 643258..644298 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" downshifts 644262 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" CDS complement(644528..646456) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" gene complement(644528..646456) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" downshifts complement(644545) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" misc_feature 646208..646227 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 646218 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" S_feature 646220..646409 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 646374..646381 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646395..646414 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646411..646581 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 646411 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" promotor_-10 complement(646476..646495) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(646488) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" promotor_-35 complement(646509..646516) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 646582..647094 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" gene 646582..647094 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" CDS 647091..647738 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" gene 647091..647738 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" promotor_no_box 647568..647668 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 647628 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" CDS 647760..647933 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" gene 647760..647933 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" CDS 647940..648704 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" gene 647940..648704 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" downshifts 648684 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" CDS complement(648742..648933) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" gene complement(648742..648933) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" downshifts complement(648759) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" CDS complement(648930..649664) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" gene complement(648930..649664) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" promotor_-35 649322..649327 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649342..649360 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 649344 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 649663..649664 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 649674..649688 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 649696 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" promotor_-10 complement(649701..649720) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 649718..649826 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(649721) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" promotor_-35 complement(649734..649739) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 649800..649806 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649820..649839 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 649828..649902 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 649828 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" CDS 649903..650187 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" gene 649903..650187 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" CDS 650234..651868 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" gene 650234..651868 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" S_feature 651869..651961 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 651918 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" CDS complement(651956..652084) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" gene complement(651956..652084) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo S_feature 651963..653431 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(652087..652245) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" gene complement(652087..652245) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo CDS complement(652290..652418) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" gene complement(652290..652418) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo CDS complement(652511..652720) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" gene complement(652511..652720) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo CDS complement(652713..653018) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " gene complement(652713..653018) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo CDS 653432..653812 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="NP_388485.1" /db_xref="EnsemblGenomes-Gn:BSU06040" /db_xref="EnsemblGenomes-Tr:CAB12423" /db_xref="SubtiList:BG12785" /db_xref="UniProtKB/Swiss-Prot:O34672" /translation="MLSDNNFVSETLENVQYLLPGAKVIKLRGYSRAHKVYTIAKSPV EKWKVAAGLSGSEIAILIRKGHWIGASIPAGGIVIDIDDSKQGELVKGLLDAQNFHCH CIRTLMGGSLFLRITNMGKRKLNK*" gene 653432..653812 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" S_feature 653813..654070 /Source="Nicolas_S_feature" /locus_tag="new_653813_654070" /HighExp="H2O2, dia15, S1, Heat, G150, Diami, G135, G180, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.1454" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S211" CDS 654071..654343 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="YP_003097688.1" /db_xref="EnsemblGenomes-Gn:BSU06048" /db_xref="EnsemblGenomes-Tr:CAX52567" /db_xref="UniProtKB/Swiss-Prot:C0H3W7" /translation="MKAWKVEPYEISKAMELIYKYLLLDKKDFSLEEFYKLTIYAIKW KLEQAQFPLYLESTKKSHQNVIPQPFKIKGNVLYKTVIKNSGDFEE*" gene 654071..654343 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" CDS 654333..654692 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage terminase (fragment); defective prophage 3" /db_xref="PSEUDO:CAX52568.1" /translation="MKNSSSWRVGVIHPFKKLSNIERNSVHYELASNDNGREKKDIVP ASVISPSGSCFSLADNGLVEKEGQKMKLTERQRRFCDFFTETRNTTEATRLAGNKGKN LNRVASQNLSKLDIQTI*" gene 654333..654692 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /pseudo S_feature 654693..655136 /Source="Nicolas_S_feature" /locus_tag="new_654693_655136" /HighExp="H2O2, dia15, S1, G180, G135, G150, Heat, Diami, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S212" CDS 654978..655193 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative N-terminus of restriction enzyme; defective prophage 3" /db_xref="PSEUDO:SOX90546.1" /translation="MIKFSVILGMIRCSLTHITTKNTVNALKRMIYPKQKPSFFHEFK VLYKLLKKFCIKGIMIKNIRSCMGYFL*" gene 654978..655193 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /pseudo promotor_-35 655123..655129 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 655138..655222 /Source="Nicolas_S_feature" /locus_tag="new_655138_655222" /HighExp="Diami, H2O2, dia5, dia15, Salt, M40t45, G180, G150, G135, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S213" upshifts 655138 /Source="Nicolas_upshifts" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" promotor_-10 655143..655162 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 655223..656506 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 12682299, 16014871, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 12682299, 16014871, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); prophage 3 region" /protein_id="NP_388487.1" /db_xref="EnsemblGenomes-Gn:BSU06060" /db_xref="EnsemblGenomes-Tr:CAB12425" /db_xref="GOA:O34939" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12787" /db_xref="UniProtKB/Swiss-Prot:O34939" /translation="MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVT SRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWE ACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRI KDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPG IIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQIN EFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPD CHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFP DFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR*" gene 655223..656506 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" CDS 656528..657697 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); defective prophage 3" /protein_id="NP_388488.1" /db_xref="EnsemblGenomes-Gn:BSU06070" /db_xref="EnsemblGenomes-Tr:CAB12426" /db_xref="GOA:O34680" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR018117" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR031303" /db_xref="SubtiList:BG12788" /db_xref="UniProtKB/Swiss-Prot:O34680" /translation="MKVVSLFSGIGGIELGLHQSGHTTEIFCEVDPLAKAVLSKNFPG VKIEDDINEIRELPSCDLVAAGFPCQDLSQAGGKEGIDGSRSGLVKKLFELIEKKEHA NRPPWILIENVPYMLRLNRGKAMSYLTSVLSELGYTWAYRTVDARCFGLPQRRHRVIL LASLFEDPKDVIFSQDHSEPDLDGKPSVVDHSNYYGFYWTEGLRGVGWAREAVPPIKC GSSVGIASPPAVWSPYEDIVGTINIRDAERLQGFPEDWTNITTETGKDIKEGARWRLV GNAVSVRVSKWIGENLSQPKGSISDFEGELVTKTWPSAAWGYGDKKYKVPVSKWVANT EQIAISEFLNHPLKPLSARALNGFLGRAARCTNVNYSDEFINSLERCKDRQLQKV*" gene 656528..657697 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" downshifts 657703 /Source="Nicolas_upshifts" /id="D293" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="2.10319" /MaxDrop="7.17612" /score="34.7238204" /energy="-15.1" /TU="NA" /idTUdmin="U468" /TUdmin=0 /isTUend="TRUE" downshifts complement(657777) /Source="Nicolas_upshifts" /id="D294" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="2.48582" /MaxDrop="4.12737" /score="11.0887998" /energy="-15.6" /TU="NA" /idTUdmin="U471" /TUdmin=2 /isTUend="TRUE" CDS complement(657793..658062) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; C-terminal part of YdzW; defective prophage 3" /db_xref="PSEUDO:CAX52569.1" /translation="MNLASFGSVKVTTVEDYLTGIERLWKALRNSWAFHSQMFLNVFL KSDPWMCLRLSGTEPKIKFYFRVDESLAETRNPQRIEKEFMELVE*" gene complement(657793..658062) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /pseudo CDS complement(658019..658189) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="MSLYEALLSIEEYGYFQEGLRSLTLKGKEGAELIQQTLAAFRSE FGQLWFRQGYHC*" gene complement(658019..658189) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /pseudo CDS complement(658120..658605) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /EC_number="5.4.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="LIATDPDADRLGIAVKNENGEYTVLTGNQTEPLLLHYILTQIKK KGTLPSNGIVLKTIVTSELGREVATSFRVETIGVLTGFKFIARKINGYYKTGEHNFLF GYEESYGYLIGDFVRDKDAVQTDVLAVEVCAYYKKKGFHYTKLSLVLKNMATFRKACA H*" gene complement(658120..658605) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /pseudo promotor_-35 658470..658473 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658488..658507 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658492 /Source="Nicolas_upshifts" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" S_feature 658495..658899 /Source="Nicolas_S_feature" /locus_tag="new_658495_658899" /HighExp="Cold, LoTm, C30, T0.30H, HPh, Gly, S0, LPh, UNK1, T1.0H" /AntisenseName="ydzW" /AntisenseCor="0.298083403528066" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S214" CDS complement(658615..658758) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /db_xref="PSEUDO:CAX52572.1" /translation="MALAAMNYKHVAVGKEQEQPALCFPLSPVQMLKNMPRLSWPSGK AAN*" gene complement(658615..658758) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /pseudo CDS complement(658813..659010) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="FAVRHLHGFAGIVVTASHNPPEYNGYKVYGPDGGQLPPSKGPDQ NIAQRWTRHTLNYFRKLKYLR*" gene complement(658813..659010) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /pseudo CDS complement(658968..659129) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /translation="DIYTLRKVSAGLAAFIMEAARTLASSAYVFESLRPTTVLSLQYV TFMVLPVLL*" gene complement(658968..659129) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /pseudo CDS complement(659114..659221) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; N-terminal part of YdzW; defective prophage 3" /translation="MRKTWKMLFIRNLGYGTGGMRGEIGAGTNRMTSIR*" gene complement(659114..659221) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /pseudo S_feature complement(659222..659341) /Source="Nicolas_S_feature" /locus_tag="new_659222_659341_c" /HighExp="LoTm, T4.0H, BC, T5.0H, M9-stat, T3.30H, S2, T3.0H, Sw, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S215" promotor_-10 complement(659332..659351) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(659341) /Source="Nicolas_upshifts" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" S_feature complement(659343..659558) /Source="Nicolas_S_feature" /locus_tag="new_659343_659558_c" /HighExp="LBGstat, T0.30H, M9-stat, T1.0H, T1.30H, Lbtran, T2.0H, LBGtran, T2.30H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.11296" /TUshortSig="SigA" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S216" promotor_-35 complement(659367..659370) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 659535..659541 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(659544..659563) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-10" promotor_-10 659554..659573 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(659558) /Source="Nicolas_upshifts" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" upshifts 659560 /Source="Nicolas_upshifts" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" promotor_-35 complement(659578..659581) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-35" CDS 659623..660564 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814, 15728999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 15728999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRA (YdiR); prophage region 3" /protein_id="NP_388490.1" /db_xref="EnsemblGenomes-Gn:BSU06090" /db_xref="EnsemblGenomes-Tr:CAB12428" /db_xref="GOA:O35025" /db_xref="SubtiList:BG12790" /db_xref="UniProtKB/Swiss-Prot:O35025" /translation="MTFIKRLEDAYETLLGNYPAGVSSTSTSKYNEIRKIVSEAFLIG ENEVYVTGTSRRISNLDTRFAQGNQRNKHTRMAVAFISIPSVDDSELDELIIRTRNSA ITTSSKFCNGEERGTIFDGILLFLVFEGETKVYPLAFLVFENDFELKEKAEELIPGIE LKEYPRANQSPAQENNKSAKNEDEESAKSYVVFLDIEEDGSIVEFVEDKDKTYRIGDM IWTASHTNGSSAITRRLEVIEVVENLVVCKIKHKYNEPVDKNSLLKFVNIEQDLISFL DLHPNVQNGSEGFVSGDIVDENATTSSDDLPEDFENN*" gene 659623..660564 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" CDS 660596..661627 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRB (YdiS); prophage region 3" /protein_id="NP_388491.1" /db_xref="EnsemblGenomes-Gn:BSU06100" /db_xref="EnsemblGenomes-Tr:CAB12429" /db_xref="GOA:O34885" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12791" /db_xref="UniProtKB/Swiss-Prot:O34885" /translation="MEISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGK SNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQFIGAYKPVPIYKKLSGEEEIFSSNFR DKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVFGDIFQLLD RNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFK RRWSFEYLELEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGP FFLKESELWNQNVFKNKLLYYLKEDVFKHNPTIDFLNASTFSELIEKYDGSDNIFTFD IDDSSFVSD*" gene 660596..661627 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" CDS 661630..663027 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" /EC_number="3.1.21.4" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRC (YdjA); prophage region 3" /protein_id="NP_388492.1" /db_xref="EnsemblGenomes-Gn:BSU06110" /db_xref="EnsemblGenomes-Tr:CAB12430" /db_xref="GOA:O34303" /db_xref="InterPro:IPR018579" /db_xref="SubtiList:BG12792" /db_xref="UniProtKB/Swiss-Prot:O34303" /translation="MDKSSKFFFEDQKYNKERIVRVLGGNLALLKSKGILYEDSSGDL IFNYVGVISNGRNVIFILPKYCNRHLDEHSKRTLFNKLLKIFKKYSGLNKSRESDYFV SELDSDEVSDFMIADYLLNDFSLNGYYQKKFTEYEIDGEGIIDWSKTVNEITPVFSKG VPYYFSTYNEVVQKDEYHLIVKIHKWALSKYFNDFGVILGFTGLEFDKSCDGMKILDY ADFFGSVINKEIVNTYVDRDVKLLKALKTAIDREENQFSKRPTLSLYGTKYFHRVWEE VCKTVFSHVNEYVKKISRPNWINFTDIEVNKEKKTLEPDIIKAFEYRSKEYFLILDAK YYNINFDGKKLEGNPGVEDITKQLLYDKALEKLSRGKTKHNAFLFPSSNSTNTFKVFG SVDFDFLDIAAVTLVYISAEQVYNLYLENKTFSTDDLFKFVSEINKSKKRHSVITSTL YGNMFLFTKRLSDKN*" gene 661630..663027 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" S_feature 663028..663224 /Source="Nicolas_S_feature" /locus_tag="new_663028_663224" /HighExp="Lbtran, C90, M40t45, HPh, M0t45, LBGtran, aero, Lbstat, BI, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S217" downshifts 663181 /Source="Nicolas_upshifts" /id="D295" /incds=0 /nref=3 /ntot=131 /MaxReadThrough="5.36465" /MaxDrop="3.0162" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1364" /isTUend="FALSE" downshifts 663243 /Source="Nicolas_upshifts" /id="D296" /incds=0 /nref=5 /ntot=69 /MaxReadThrough="4.58628" /MaxDrop="3.49698" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1302" /isTUend="FALSE" S_feature 663288..663600 /Source="Nicolas_S_feature" /locus_tag="new_663288_663600" /HighExp="dia15, Diami, H2O2, Paraq, dia5, LBGstat, G180, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S218" CDS 663601..663936 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage region 3" /protein_id="NP_388493.1" /db_xref="EnsemblGenomes-Gn:BSU06120" /db_xref="EnsemblGenomes-Tr:CAB12431" /db_xref="SubtiList:BG12793" /db_xref="UniProtKB/Swiss-Prot:O34778" /translation="MLNIKSDRIMTSDPQKFTVDGVRFFQQYLNKIRPDAMEIDNLII NSDIIKEDLIVHVSKMIDRLALYDLHRKRSIDKHFSAAFTVDINDREEFYSANIADVS IDLNESSGV*" gene 663601..663936 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" S_feature 663937..664318 /Source="Nicolas_S_feature" /locus_tag="new_663937_664318" /HighExp="H2O2, dia15, G135, Paraq, G180, G150, Diami, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S219" CDS 664319..664669 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388494.1" /db_xref="EnsemblGenomes-Gn:BSU06130" /db_xref="EnsemblGenomes-Tr:CAB12432" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12794" /db_xref="UniProtKB/Swiss-Prot:O34715" /translation="MVSIFYANRLSYSIWNTIPGKYIREELEQNGVTYNELIKYWDIT DPSQALPKVNKDNVLLISAKHDQYIDLKDADYLWESWGRPTRYVYNCGHSGIVLCRKK LANDTLSFIREKLV*" gene 664319..664669 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" downshifts 664545 /Source="Nicolas_upshifts" /id="D297" /incds=1 /nref=1 /ntot=71 /MaxReadThrough="1.89703" /MaxDrop="2.58458" /score="-4.72838456" /energy="-13.9" /TU="NA" /idTUdmin="U473" /TUdmin=0 /isTUend="TRUE" CDS complement(664775..667264) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" gene complement(664775..667264) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" downshifts complement(664797) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(667278..667297) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667304) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" promotor_-35 complement(667311..667318) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 667367..667368 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 667383..667465 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 667383 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" promotor_-10 667384..667403 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 667466..668527 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" gene 667466..668527 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" CDS 668601..669992 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" gene 668601..669992 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" promotor_-35 670019..670026 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 670040..670059 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 670045 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" CDS 670087..671049 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" gene 670087..671049 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" downshifts 671034 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" promotor_-35 671174..671183 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 671190 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" promotor_-10 671196..671211 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 671245..671928 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" gene 671245..671928 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" S_feature 671929..671993 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 671994..673019 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" gene 671994..673019 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" CDS 673019..673783 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" gene 673019..673783 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" CDS 673814..674785 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" gene 673814..674785 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" downshifts 674775 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" downshifts 674819 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" CDS complement(674832..675857) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" gene complement(674832..675857) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" promotor_-10 complement(675889..675908) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(675907) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" promotor_-35 complement(675922..675928) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 676117..676124 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 676137 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" S_feature 676139..676441 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 676139..676158 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 676442..677863 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" gene 676442..677863 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" downshifts 677855 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" downshifts complement(677911) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" CDS complement(677911..678951) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" gene complement(677911..678951) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" promotor_-35 678491..678500 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678514..678533 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 678515..679050 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 678515 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" S_feature complement(678952..679246) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 679051..679070 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 679052..679349 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 679052 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" misc_feature complement(679241..679255) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(679246) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" promotor_-35 679329 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679348..679367 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 679351 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" CDS 679390..679761 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" gene 679390..679761 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" downshifts 679747 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" CDS 679827..680873 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" gene 679827..680873 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" downshifts 680847 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" CDS complement(680907..681065) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" gene complement(680907..681065) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" downshifts complement(680923) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" S_feature complement(681122..681254) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(681165) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" CDS complement(681255..681464) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" gene complement(681255..681464) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" promotor_-10 complement(681497..681516) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(681508) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(681533) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(681547..682362) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" gene complement(681547..682362) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" promotor_-35 682189..682198 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682211..682230 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682211 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(682375..683364) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" gene complement(682375..683364) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" promotor_-10 complement(683229..683247) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(683237) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(683263..683268) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(683386..683401) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(683407) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" promotor_-35 complement(683413..683422) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(683462..685003) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" gene complement(683462..685003) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" downshifts complement(683475) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(685034..685053) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(685048) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" promotor_-35 complement(685067..685076) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(685155..686564) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" gene complement(685155..686564) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" downshifts complement(685169) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" CDS complement(686602..686889) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" gene complement(686602..686889) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" misc_feature complement(686605..686624) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(686619) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" promotor_-35 686895..686902 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 686918..686937 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 686919 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" CDS 686962..687834 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" gene 686962..687834 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" downshifts 687799 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" downshifts complement(688074) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" misc_feature 688128..688147 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 688138 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" CDS 688184..689146 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" gene 688184..689146 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" CDS 689146..690342 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" gene 689146..690342 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" CDS 690364..692577 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" gene 690364..692577 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" promotor_-35 692572..692579 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 692594..692613 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 692610..692739 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 692610 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" CDS 692740..694281 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" gene 692740..694281 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" downshifts 694267 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" promotor_-35 694388..694392 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 694408..694427 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 694418 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" misc_RNA 694425..694527 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 694425..694527 /gene="gswC" /locus_tag="BSU_misc_RNA_9" downshifts 694553 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" CDS 694662..695984 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" gene 694662..695984 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" downshifts 695962 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" downshifts 696005 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" promotor_-35 696034..696043 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 696054..696194 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 696054 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" promotor_-10 696056..696071 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 696195..696998 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" gene 696195..696998 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" downshifts 696983 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" promotor_-35 697066..697073 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697087..697106 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 697093..697156 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 697093 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" CDS 697157..697324 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" gene 697157..697324 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" downshifts 697331 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" promotor_-35 697375..697381 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697396..697414 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 697399..697485 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 697399 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" promotor_-35 697464..697471 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697485..697504 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 697487 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" CDS 697538..698092 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" gene 697538..698092 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" CDS 698092..698289 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" gene 698092..698289 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" downshifts 698279 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" promotor_-35 698335..698342 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698357..698376 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698359 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" misc_RNA 698369..698471 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 698369..698471 /gene="gswD" /locus_tag="BSU_misc_RNA_10" S_feature 698472..698611 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 698612..699100 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" gene 698612..699100 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" CDS 699093..700235 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" gene 699093..700235 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" CDS 700232..701527 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" gene 700232..701527 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" promotor_-10 complement(700537..700556) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(700558) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(700571..700578) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 701601..702326 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" gene 701601..702326 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" CDS 702319..702573 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" gene 702319..702573 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" CDS 702570..703253 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" gene 702570..703253 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" CDS 703237..705465 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" gene 703237..705465 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" downshifts complement(703485) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" CDS 705441..706871 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" gene 705441..706871 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" S_feature 706872..706972 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 706973..708013 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" gene 706973..708013 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" CDS 708010..708597 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" gene 708010..708597 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" misc_feature 708020..708034 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 708029 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" promotor_-10 complement(708296..708314) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708303) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(708330..708335) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 708594..710132 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" gene 708594..710132 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" CDS 710148..711416 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" gene 710148..711416 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" downshifts 711401 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" CDS complement(711456..711875) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" gene complement(711456..711875) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" misc_feature complement(711945..711964) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(711954) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" CDS 712019..713293 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" gene 712019..713293 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" downshifts 713242 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" CDS complement(713308..713535) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" gene complement(713308..713535) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" downshifts complement(713319) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" S_feature complement(713536..713956) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 713603..713608 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 713619 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" promotor_-10 713622..713641 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 713664..715406 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" gene 713664..715406 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" promotor_-10 complement(713941..713952) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713956) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" promotor_-35 complement(713966..713972) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 713987 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" promotor_-35 715380..715386 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 715398 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" promotor_-10 715399..715418 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 715433..716428 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" gene 715433..716428 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" CDS 716431..716745 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" gene 716431..716745 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" downshifts 716608 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" downshifts 716750 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" CDS complement(716780..718357) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" gene complement(716780..718357) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" downshifts complement(716794) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(718371..718390) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718390) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" promotor_-35 complement(718405..718411) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 718554..718557 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 718571 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" promotor_-10 718574..718593 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 718622..719308 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" gene 718622..719308 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" CDS 719370..721589 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " gene 719370..721589 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" CDS 721613..723619 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" gene 721613..723619 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" CDS 723635..724825 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" gene 723635..724825 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" misc_feature complement(723830..723834) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(723834) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 724862..724881 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 724870..724986 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 724870 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" downshifts complement(724934) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" CDS 724987..725997 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" gene 724987..725997 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" promotor_no_box complement(725004..725104) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(725044) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 725980 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" S_feature 726024..726828 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(726035..726733) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" gene complement(726035..726733) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" downshifts complement(726056) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(726753..726771) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726774) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" promotor_-35 complement(726787..726792) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(726840..728318) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" gene complement(726840..728318) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" downshifts complement(726854) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" upshifts complement(727706) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" misc_feature complement(727709..727722) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(728319..728449) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(728440..728458) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728449) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" promotor_-35 complement(728473..728479) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 728580..728583 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 728598..728731 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 728598 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" promotor_-10 728600..728619 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 728732..729022 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" gene 728732..729022 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" CDS 729038..730495 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" gene 729038..730495 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" CDS 730509..731939 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" gene 730509..731939 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" downshifts 731920 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" CDS complement(731954..732823) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" gene complement(731954..732823) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" downshifts complement(731996) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" promotor_-35 732613..732618 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 732634..732652 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 732646 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" S_feature complement(732824..732898) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 732876..732883 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(732892..732911) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732898 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" promotor_-10 732899..732918 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732905) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" promotor_-35 complement(732926..732933) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732955..736113 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" gene 732955..736113 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" downshifts 736100 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" promotor_-35 736352..736355 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736370..736389 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736378 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" CDS 736436..737347 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" gene 736436..737347 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" S_feature 737348..737602 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 737603..738982 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" gene 737603..738982 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" S_feature 738983..739575 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(738995..739897) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" gene complement(738995..739897) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" downshifts 739532 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" S_feature 739577..739877 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 739878..740213 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" gene 739878..740213 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" S_feature 740214..740287 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 740288..742927 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" gene 740288..742927 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" CDS 742939..744738 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" gene 742939..744738 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" promotor_-10 complement(743179..743194) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743194) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(743206..743215) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744739..744850 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 744851..745999 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" gene 744851..745999 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" S_feature 746000..747189 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(746261..746566) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " gene complement(746261..746566) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" CDS complement(746633..746839) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" gene complement(746633..746839) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" CDS complement(747079..747534) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" gene complement(747079..747534) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" downshifts complement(747092) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" CDS complement(747554..749563) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" gene complement(747554..749563) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" promotor_-10 complement(747921..747940) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(747928) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" promotor_-35 complement(747953..747958) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(749590..749609) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(749600) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" CDS 749775..750797 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" gene 749775..750797 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" promotor_-35 750897..750904 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 750918..750937 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 750919 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" CDS 750959..752089 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" gene 750959..752089 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" CDS 752079..752252 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" gene 752079..752252 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" downshifts 752207 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" S_feature 752253..752357 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 752324..752331 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752346..752365 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752359 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" CDS 752412..753131 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" gene 752412..753131 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" downshifts complement(752414) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" promotor_-35 752989..752996 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753010..753029 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753020 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" downshifts 753113 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" promotor_-35 753200..753209 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753223..753242 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753226 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" promotor_-10 complement(753230..753248) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(753250) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(753264..753269) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 753265..753702 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" gene 753265..753702 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" downshifts complement(753272) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" downshifts 753702 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" promotor_-35 753762..753769 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753785..753804 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753790 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" CDS 753817..754401 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" gene 753817..754401 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" downshifts 754382 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" CDS 754480..754923 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" gene 754480..754923 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" CDS 754920..755780 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" gene 754920..755780 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" promotor_-35 755842..755847 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755863..755881 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755863 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" promotor_-10 complement(755885..755899) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(755890) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(755907..755911) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 755907..756155 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" gene 755907..756155 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" CDS 756139..756402 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" gene 756139..756402 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" CDS 756417..756986 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" gene 756417..756986 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" S_feature 756987..757065 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 757038..757043 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 757058..757077 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 757067 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" CDS 757111..757653 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" gene 757111..757653 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" downshifts 757620 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" CDS 757676..757978 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" gene 757676..757978 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" promotor_-35 758021..758029 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758040..758058 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 758046 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" CDS 758093..758722 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" gene 758093..758722 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" CDS 758719..760452 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" gene 758719..760452 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" CDS 760452..761558 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" gene 760452..761558 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" downshifts 761512 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" promotor_-35 761597..761600 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761615..761634 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761622 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 761662..762945 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" gene 761662..762945 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" CDS 762942..763871 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" gene 762942..763871 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" CDS 763875..764765 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" gene 763875..764765 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" CDS 764781..765815 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" gene 764781..765815 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" CDS 765838..768123 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" gene 765838..768123 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" CDS 768137..768835 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" gene 768137..768835 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" CDS 768828..769490 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" gene 768828..769490 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" CDS 769487..770113 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" gene 769487..770113 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" CDS 770234..772096 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" gene 770234..772096 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" promotor_no_box 770274..770374 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 770334 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(770872) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(770873..770892) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(770905..770914) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 772142..773980 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" gene 772142..773980 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" CDS 774138..774791 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " gene 774138..774791 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" CDS 774799..776790 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" gene 774799..776790 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" CDS 776834..779407 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" gene 776834..779407 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" promotor_-10 complement(778156..778174) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(778169) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(778190..778195) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 779529..781037 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" gene 779529..781037 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" CDS 781092..782048 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" gene 781092..782048 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" downshifts complement(781366) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" promotor_no_box complement(781392..781492) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(781432) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 782062..782949 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" gene 782062..782949 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" promotor_-35 782696..782701 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 782717..782735 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 782720 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" CDS 782958..784298 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" gene 782958..784298 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" S_feature complement(783392..785083) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 784299..784380 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 784381..785076 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" gene 784381..785076 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" downshifts 785074 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" CDS complement(785113..785439) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" gene complement(785113..785439) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" downshifts complement(785128) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" downshifts 785426 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" promotor_-10 complement(785462..785481) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(785480) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" promotor_-35 complement(785496..785503) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(785543..785905) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" gene complement(785543..785905) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" promotor_-10 complement(785928..785947) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(785942) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" promotor_-35 complement(785960..785966) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(785976..786536) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(786008) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(786519..786538) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786536) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" promotor_-35 complement(786552..786561) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786624..786631 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 786640 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" promotor_-10 786644..786663 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 786689..787270 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" gene 786689..787270 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo CDS 787264..787560 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" gene 787264..787560 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo downshifts 787552 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" promotor_-35 787631..787638 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787652..787671 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 787660 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" CDS 787715..787882 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" gene 787715..787882 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" promotor_-35 787924..787931 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787947..787966 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 787948 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" CDS 787992..788636 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" gene 787992..788636 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" downshifts 788572 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" downshifts 788616 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" CDS 788636..789628 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" gene 788636..789628 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" downshifts 789562 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" downshifts 789606 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" CDS complement(789652..790155) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" gene complement(789652..790155) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" promotor_-10 complement(790180..790199) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790188) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" promotor_-35 complement(790213..790220) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 790318..791427 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" gene 790318..791427 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" downshifts 791410 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" CDS complement(791462..792532) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" gene complement(791462..792532) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" downshifts complement(791486) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(792563..792582) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(792589) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" promotor_-35 complement(792597..792604) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 792612..792618 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792633..792651 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 792642 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" CDS 792682..795867 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" gene 792682..795867 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" downshifts 795854 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" promotor_-35 795917..795922 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 795938..795956 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 795959 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" promotor_-35 795987..795990 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796007..796026 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 796008..796313 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 796008 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" CDS 796314..798233 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" gene 796314..798233 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" downshifts 798232 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" promotor_-35 798321..798330 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 798340..798468 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 798340 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" promotor_-10 798344..798363 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(798394) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" CDS 798469..799233 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" gene 798469..799233 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" CDS 799240..800208 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" gene 799240..800208 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" CDS 800232..801143 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" gene 800232..801143 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" promotor_-35 801021..801030 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801043..801062 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801046 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" CDS 801172..802350 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" gene 801172..802350 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" promotor_-35 801891..801897 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801912..801931 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801926 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 802351..803286 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" gene 802351..803286 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" downshifts 803158 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" downshifts 803268 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" downshifts complement(803309) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" CDS complement(803317..804546) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" gene complement(803317..804546) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" promotor_-10 complement(804575..804594) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(804593) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" promotor_-35 complement(804610..804617) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(804657..805364) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" gene complement(804657..805364) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" downshifts complement(804686) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" misc_feature complement(805387..805406) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(805410) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" CDS complement(805456..806841) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" gene complement(805456..806841) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" downshifts complement(805478) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(806890..806909) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(806907) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" promotor_-35 complement(806924..806931) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 807009..807016 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 807024 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" promotor_-10 807030..807048 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 807091..808548 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" gene 807091..808548 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" promotor_-10 complement(807884..807903) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(807898) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(807916..807925) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 808562..809422 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" gene 808562..809422 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" downshifts 809406 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" promotor_-35 809490..809497 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809511..809530 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809516 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" CDS 809557..811446 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" gene 809557..811446 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" downshifts 811430 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" misc_feature 811510..811529 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 811518 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" CDS 811569..812015 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" gene 811569..812015 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" downshifts complement(811571) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(811655..811658) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811660) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(811676..811677) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 812002 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" promotor_-35 812078..812085 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812099..812118 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812111 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" CDS 812140..812562 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" gene 812140..812562 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" downshifts 812398 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" CDS 812628..813818 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" gene 812628..813818 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" downshifts complement(813882) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" CDS 814109..814264 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" gene 814109..814264 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" CDS complement(814384..815940) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" gene complement(814384..815940) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" downshifts complement(814408) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" promotor_-35 815770..815776 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815791..815802 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815808 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" promotor_-10 complement(815990..816009) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(815994) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" promotor_-35 complement(816025..816029) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 816050..816053 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 816069..816088 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 816072 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" CDS 816113..817243 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" gene 816113..817243 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" downshifts 817226 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" CDS 817311..817757 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" gene 817311..817757 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" CDS complement(817810..818829) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" gene complement(817810..818829) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" downshifts complement(817820) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(818850..818869) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818854) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" S_feature complement(818856..819310) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(818882..818889) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818948..818955 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818969..818988 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 818976..820073 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 818976 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" CDS complement(819311..820531) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" gene complement(819311..820531) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" promotor_-10 complement(820568..820587) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820575) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" promotor_-35 complement(820603..820610) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 820629..820636 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 820648..820823 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 820648 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" promotor_-10 820651..820670 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 820780 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" CDS 820867..822330 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" gene 820867..822330 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" S_feature complement(821232..822902) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 822331..822824 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 822812..822817 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 822826..826091 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 822826 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" promotor_-10 822833..822851 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(822903..823703) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" gene complement(822903..823703) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" CDS complement(823716..824717) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " gene complement(823716..824717) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" promotor_-10 complement(824303..824322) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(824315) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(824337..824344) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(824714..825715) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " gene complement(824714..825715) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" misc_feature complement(825785..825804) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(825787..826734) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" gene complement(825787..826734) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" downshifts complement(825806) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" upshifts complement(825806) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" promotor_-35 826061..826066 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826082..826100 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 826093..826718 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 826093 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" misc_feature 826714..826733 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 826720..827251 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 826720 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" promotor_-10 complement(826776..826795) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826783) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(826809..826816) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826843..827211) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" gene complement(826843..827211) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" S_feature complement(827212..827324) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(827313..827332) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(827324) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" promotor_-35 complement(827344..827351) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 827392..827398 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827412..827430 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827412 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" CDS 827455..827802 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" gene 827455..827802 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" downshifts complement(827456) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" downshifts 827798 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" S_feature 827843..827923 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 827924..827943 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 827925 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" CDS 827993..829255 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" gene 827993..829255 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" downshifts 829250 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" promotor_-35 829308..829311 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829326..829345 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829334 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" CDS 829382..830818 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" gene 829382..830818 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" downshifts 830810 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" misc_feature 830909..830928 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 830920 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" CDS 830945..832573 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" gene 830945..832573 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" CDS 832545..833225 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" gene 832545..833225 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" CDS 833228..834187 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" gene 833228..834187 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" downshifts 834156 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" promotor_-35 834279..834286 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834299..834318 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 834310..834382 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 834310 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" CDS 834383..835684 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" gene 834383..835684 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" promotor_-35 835681..835687 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835701..835712 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835702 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" CDS 835740..836534 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" gene 835740..836534 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" downshifts 836510 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" promotor_-35 836589..836592 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836607..836626 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836620 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" CDS 836653..837744 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" gene 836653..837744 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" CDS complement(837735..838010) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" gene complement(837735..838010) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" S_feature 837745..838076 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(838024..838043) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838038) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" promotor_-35 complement(838058..838065) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 838077..838742 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" gene 838077..838742 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" CDS complement(838783..838920) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" gene complement(838783..838920) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" downshifts complement(838797) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" S_feature complement(838921..839051) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(839037..839055) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 839047..839052 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(839051) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" S_feature 839062..840126 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 839063 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" promotor_-10 839068..839086 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(839071..839076) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(839077..839232) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" gene complement(839077..839232) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" S_feature complement(839233..839338) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(839339..839653) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" gene complement(839339..839653) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" S_feature complement(839654..839734) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(839735..840484) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" gene complement(839735..840484) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" promotor_-10 complement(840513..840532) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840526) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" S_feature complement(840528..841664) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(840544..840552) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840595..840596 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840616..840635 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840619 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" CDS 840656..842014 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" gene 840656..842014 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" promotor_-10 complement(841650..841669) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841664) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" promotor_-35 complement(841683..841692) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 841900 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" downshifts 842010 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" CDS complement(842047..843996) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" gene complement(842047..843996) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" downshifts complement(842064) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" promotor_-35 843106..843112 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843128..843146 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 843132..844096 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 843132 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" S_feature complement(843997..844071) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(844048..844067) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844071) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" S_feature complement(844073..844595) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(844083..844087) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844097..844234 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" gene 844097..844234 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" upshifts 844212 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" misc_feature 844213..844232 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 844253..844645 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" gene 844253..844645 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" promotor_-10 complement(844593..844611) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844608) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" promotor_-35 complement(844627..844632) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 844714..844720 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844735..844753 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844735 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" CDS 844770..846185 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" gene 844770..846185 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" downshifts complement(844771) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" promotor_no_box complement(844797..844897) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(844837) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(846182..847258) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" gene complement(846182..847258) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" S_feature 846186..849552 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(847282..847482) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" gene complement(847282..847482) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" CDS complement(847498..848652) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" gene complement(847498..848652) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" CDS complement(848633..850174) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" gene complement(848633..850174) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" promotor_-10 complement(850224..850235) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(850227) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" promotor_-35 complement(850249..850255) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 850284..850291 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 850306..850325 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 850313 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" downshifts complement(850359) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" CDS 850367..851779 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" gene 850367..851779 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" promotor_no_box complement(850385..850485) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(850425) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 851850..853535 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" gene 851850..853535 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" promotor_-10 complement(852156..852171) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852163) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(852184..852193) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 853508..853512 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853528..853547 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853531 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" CDS 853556..854272 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" gene 853556..854272 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" downshifts 854265 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" promotor_-35 854347..854350 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854366..854385 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854375 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" CDS 854412..855077 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" gene 854412..855077 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" downshifts 855058 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" CDS complement(855114..859502) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" gene complement(855114..859502) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" downshifts complement(855133) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(859535..859554) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859552) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" promotor_-35 complement(859569..859572) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859679..859685 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859699..859717 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859702 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 859745..860263 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" gene 859745..860263 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" downshifts 860249 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" downshifts complement(860293) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" S_feature 860294..861944 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(860303..861493) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" gene complement(860303..861493) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" S_feature complement(861494..861585) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(861586..861801) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" gene complement(861586..861801) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" downshifts complement(861645) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(861833..861852) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861847) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" promotor_-35 complement(861867..861868) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 861914..861921 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861936..861955 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861946 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 862004..862474 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" gene 862004..862474 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" CDS 862492..862812 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" gene 862492..862812 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" CDS 862836..863663 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " gene 862836..863663 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" promotor_-35 863642..863648 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863663..863674 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863681..863837 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 863681 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" downshifts complement(863713) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" downshifts 863812 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" CDS complement(863862..865037) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " gene complement(863862..865037) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" downshifts complement(863867) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" promotor_-35 864474..864480 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 864496..864514 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 864500..865153 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 864500 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" promotor_-10 complement(865062..865081) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865077) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" promotor_-35 complement(865095..865102) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 865143..865148 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 865155 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" promotor_-10 865163..865181 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 865205..866260 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" gene 865205..866260 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" promotor_-35 866274..866280 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866295..866306 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866299 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" CDS 866331..867125 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" gene 866331..867125 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" downshifts 867113 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" CDS complement(867164..868006) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" gene complement(867164..868006) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" downshifts complement(867166) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" CDS complement(868007..869128) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" gene complement(868007..869128) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" promotor_-10 complement(869169..869188) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869187) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" promotor_-35 complement(869204..869208) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869216..869223 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869237..869256 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869247 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" CDS 869273..869458 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" gene 869273..869458 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" downshifts 869437 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" promotor_-35 869501..869507 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 869513 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" promotor_-10 869522..869533 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 869559..870350 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" gene 869559..870350 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" downshifts 870348 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" CDS complement(870388..871248) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" gene complement(870388..871248) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" downshifts complement(870402) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(871268..871287) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(871282) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" promotor_-35 complement(871303..871306) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(871347..872306) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" gene complement(871347..872306) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" downshifts complement(871370) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(872317..872336) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(872320) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" promotor_-35 complement(872352..872355) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 872367..872371 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872385..872404 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872394 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" CDS 872425..873288 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" gene 872425..873288 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" S_feature 873289..873401 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 873402..874802 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" gene 873402..874802 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" downshifts 874814 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" promotor_-35 875108..875115 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875131..875150 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875137 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" S_feature 875144..875427 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 875428..875694 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" gene 875428..875694 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" promotor_-10 complement(875642..875661) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875660) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(875676..875679) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 875695..876176 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 876147..876150 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876167..876186 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 876178..876425 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 876178 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" CDS 876426..877403 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" gene 876426..877403 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" S_feature 877404..877496 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 877453 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" promotor_-35 877537..877543 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877555..877574 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877564 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" CDS 877599..878051 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" gene 877599..878051 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" CDS 878081..878770 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" gene 878081..878770 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" downshifts 878775 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" misc_feature 878947..878965 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 878954 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" CDS 879002..880003 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " gene 879002..880003 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" CDS 880007..881035 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" gene 880007..881035 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" CDS 881049..882245 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" gene 881049..882245 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" downshifts complement(881050) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" CDS 882266..883642 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" gene 882266..883642 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" downshifts 883636 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" promotor_-35 883689..883696 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883709..883728 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883717 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" CDS 883758..885575 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" gene 883758..885575 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" promotor_-35 885576..885582 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 885594 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" promotor_-10 885597..885608 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 885629..885808 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" gene 885629..885808 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" downshifts 885792 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" CDS complement(885844..886173) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" gene complement(885844..886173) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" downshifts complement(885858) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" CDS complement(886223..886681) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" gene complement(886223..886681) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" S_feature complement(886682..886774) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(886775..887332) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" gene complement(886775..887332) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" promotor_-35 887198..887203 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 887211 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" promotor_-10 887218..887236 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 887222..887809 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(887364..888131) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" gene complement(887364..888131) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" CDS complement(888143..889366) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" gene complement(888143..889366) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" CDS complement(889372..889686) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" gene complement(889372..889686) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" promotor_-10 complement(889734..889753) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889747) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" promotor_-35 complement(889768..889771) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 889978..889997 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889981 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" CDS 890022..891371 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " gene 890022..891371 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" misc_feature 891400..891419 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 891402 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" CDS 891436..892200 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" gene 891436..892200 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" promotor_-10 complement(891580..891594) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(891610..891616) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(891610) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 892215..893798 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" gene 892215..893798 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" downshifts 893778 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" promotor_-35 893827..893834 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893849..893868 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893857 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" CDS 893904..895625 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" gene 893904..895625 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" CDS 895619..897433 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" gene 895619..897433 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" downshifts 897408 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" promotor_-35 897515..897522 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897536..897555 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897540 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" CDS 897588..897992 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" gene 897588..897992 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" CDS 898010..898867 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" gene 898010..898867 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" downshifts 898854 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" CDS 898961..899905 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" gene 898961..899905 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" downshifts complement(899772) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" promotor_no_box complement(899820..899920) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(899860) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 900080..901528 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" gene 900080..901528 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" CDS 901555..902496 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" gene 901555..902496 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" CDS 902506..903687 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" gene 902506..903687 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" downshifts 903677 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" promotor_-35 903747..903753 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903768..903787 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903786 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" CDS 903811..905013 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" gene 903811..905013 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" CDS 905010..905672 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" gene 905010..905672 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" downshifts 905680 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" CDS 905816..906751 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" gene 905816..906751 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" CDS 906764..907954 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" gene 906764..907954 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" CDS 907968..909125 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" gene 907968..909125 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" promotor_-35 908079..908084 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908099..908117 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908100 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(909123..909197) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(909166) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" CDS complement(909198..909746) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" gene complement(909198..909746) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" S_feature complement(909747..909826) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(909815..909834) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(909826) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" promotor_-35 complement(909848..909853) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 909949..909952 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909968..909987 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909975 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" CDS 910019..910651 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" gene 910019..910651 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" downshifts 910630 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" promotor_-35 910766..910771 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910785..910804 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910795 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" CDS 910840..911928 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" gene 910840..911928 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" S_feature complement(911330..911718) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(911718) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" promotor_-10 complement(911720..911739) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(911752..911760) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(911964..912581) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" gene complement(911964..912581) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" downshifts complement(911982) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" CDS complement(912547..913800) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" gene complement(912547..913800) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" promotor_-10 complement(912608..912627) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(912620) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" promotor_-35 complement(912641..912648) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(913834..913853) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913852) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(913868..913875) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 913879..913898 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 913884 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" CDS 913924..914460 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" gene 913924..914460 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" CDS complement(914457..916013) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" gene complement(914457..916013) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" promotor_-10 complement(916035..916053) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916052) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(916069..916072) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(916124..916606) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" gene complement(916124..916606) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" downshifts complement(916140) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(916631..916650) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916647) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" promotor_-35 complement(916665..916671) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916692..916699 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916713..916732 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916721 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" CDS 916778..919348 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" gene 916778..919348 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" downshifts 919319 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" CDS complement(919366..920343) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" gene complement(919366..920343) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" downshifts complement(919377) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" promotor_-35 920358..920365 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920370..920389) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 920380..920399 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920382..920473 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 920382 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" upshifts complement(920387) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" promotor_-35 complement(920404..920411) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920474..921475 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " gene 920474..921475 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" CDS 921472..922503 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" gene 921472..922503 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" downshifts 922484 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" promotor_-35 922554..922556 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922572..922591 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922575 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" CDS 922618..923499 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" gene 922618..923499 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" promotor_-35 923510..923517 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 923533..923552 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 923542 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" CDS 923587..924171 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" gene 923587..924171 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" downshifts 924158 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" CDS complement(924210..924401) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" gene complement(924210..924401) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" downshifts complement(924228) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" upshifts complement(924433) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" promotor_-10 complement(924436..924447) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(924462..924468) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924468..924578) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" gene complement(924468..924578) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" promotor_-10 complement(924607..924618) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(924609) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(924633..924639) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924633..925544) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" gene complement(924633..925544) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" promotor_-35 925430..925433 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925450..925469 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 925460..925632 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 925460 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" promotor_-10 complement(925566..925584) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925580) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(925598..925604) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 925633..926427 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" gene 925633..926427 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" CDS 926429..926743 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" gene 926429..926743 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" S_feature complement(926651..926919) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 926733 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" promotor_-35 926817..926822 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926838..926857 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926843 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" CDS 926886..928079 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" gene 926886..928079 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" S_feature 928080..928314 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(928112..928264) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" gene complement(928112..928264) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" downshifts complement(928129) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" promotor_-35 928293..928300 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928314..928333 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 928316..928388 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 928316 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" promotor_-10 complement(928323..928334) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928333) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" promotor_-35 complement(928349..928355) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 928389..928658 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" gene 928389..928658 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" downshifts 928647 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" promotor_-35 928736..928742 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 928757 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 928758..928776 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 928803..929321 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" gene 928803..929321 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" S_feature 929322..929389 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 929357..929366 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 929378..929393 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 929391 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" CDS 929406..929738 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" gene 929406..929738 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" CDS 929725..930585 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" gene 929725..930585 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" downshifts 930583 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" promotor_-35 930643..930649 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930663..930674 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 930671..930735 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 930671 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" promotor_-10 complement(930693..930712) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930702) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 930718..930724 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(930726..930727) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 930737..930817 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 930737 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 930739..930757 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930818..931807 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" gene 930818..931807 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" upshifts complement(930967) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(930972..930976) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(930993..930997) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 931808..931878 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 931879..934464 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" gene 931879..934464 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" downshifts 934433 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" CDS complement(934457..935440) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" gene complement(934457..935440) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" downshifts complement(934491) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" promotor_-35 934914..934923 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934936..934955 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934940 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(935441..935588) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 935545..935549 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935565..935584 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935572 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 935578..935655 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(935586..935605) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935588) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" promotor_-35 complement(935620..935627) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 935656..936765 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" gene 935656..936765 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" promotor_-35 936602..936606 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936622..936641 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936634 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 936766..937078 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(936773..936997) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" gene complement(936773..936997) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" promotor_-10 complement(937027..937038) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937029) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" promotor_-35 complement(937052..937058) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 937079..937831 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" gene 937079..937831 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" promotor_-35 937848..937854 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 937869..937880 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 937870 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" promotor_-10 complement(937877..937891) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937898) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(937900..937904) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 937900..938154 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" gene 937900..938154 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" downshifts 938152 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" downshifts complement(938177) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" CDS 938243..938587 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" gene 938243..938587 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" promotor_-35 938250..938258 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938269..938287 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938271 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" downshifts 938570 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" promotor_-35 938626..938633 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938647..938666 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938656..938730 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 938656 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" CDS 938731..939261 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" gene 938731..939261 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" downshifts 939252 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" CDS 939349..941091 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" gene 939349..941091 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" downshifts 941078 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" CDS complement(941168..942229) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" gene complement(941168..942229) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" downshifts complement(941179) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" S_feature complement(942230..942320) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(942318..942337) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942327) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" promotor_-35 complement(942352..942359) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(942449..943738) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" gene complement(942449..943738) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" downshifts complement(942452) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(943766..943785) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943785) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" S_feature complement(943787..944498) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(943797..943802) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 943831..943838 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943852..943871 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943852 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" CDS 943891..944364 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" gene 943891..944364 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" promotor_-35 944401..944408 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 944423..944442 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 944429 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" CDS 944487..944924 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" gene 944487..944924 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" downshifts 944906 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" CDS complement(944959..945312) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" gene complement(944959..945312) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" downshifts 944972 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" downshifts complement(944982) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" promotor_-35 945308..945312 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 945320..945334 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(945324..945343) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 945324..945415 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 945324 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" upshifts complement(945334) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" promotor_-35 945392..945395 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 945410..945429 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 945417..945519 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 945417 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" CDS 945520..946404 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" gene 945520..946404 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" promotor_-35 946387..946394 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946408..946427 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 946423..946695 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 946423 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" downshifts complement(946456) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" rRNA 946696..948250 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 946696..948250 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" rRNA 948418..951345 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 948418..951345 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" S_feature 951346..951431 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 951407..951414 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951428..951447 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951433 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" rRNA 951457..951572 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951457..951572 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" tRNA 951582..951656 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951582..951656 /gene="asnTA" /locus_tag="BSU_tRNA_29" tRNA 951662..951753 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951662..951753 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" downshifts 951749 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" tRNA 951788..951859 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951788..951859 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" tRNA 951869..951944 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951869..951944 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" tRNA 951954..952030 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951954..952030 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" tRNA 952042..952118 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952042..952118 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" tRNA 952131..952206 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952131..952206 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" tRNA 952212..952284 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952212..952284 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" tRNA 952307..952391 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952307..952391 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" tRNA 952397..952470 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952397..952470 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" tRNA 952495..952570 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952495..952570 /gene="trnD-His" /locus_tag="BSU_tRNA_39" tRNA 952580..952651 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952580..952651 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" tRNA 952701..952775 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952701..952775 /gene="glyTB" /locus_tag="BSU_tRNA_41" tRNA 952781..952851 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952781..952851 /gene="cysTA" /locus_tag="BSU_tRNA_42" tRNA 952859..952947 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952859..952947 /gene="leuTA" /locus_tag="BSU_tRNA_43" S_feature 952948..953024 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 952981 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" S_feature 953026..953194 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 953151..953158 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 953157 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" promotor_-10 953172..953191 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 953196 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" tRNA 953213..953294 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 953213..953294 /gene="leuTB" /locus_tag="BSU_tRNA_44" promotor_-10 complement(953230..953247) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953233) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(953268..953273) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(953303) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" CDS complement(953373..954149) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" gene complement(953373..954149) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" downshifts complement(953387) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(954176..954191) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954198) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" promotor_-35 complement(954204..954213) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954233..954239 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954254..954265 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954257 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" CDS 954291..954494 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" gene 954291..954494 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" downshifts 954477 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" downshifts complement(954553) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" CDS complement(954579..954851) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" gene complement(954579..954851) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" promotor_-10 complement(954810..954828) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954817) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" promotor_-35 954832..954839 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(954845..954850) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954852..954871 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 954860 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" CDS 954893..955585 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" gene 954893..955585 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" promotor_-35 955614..955618 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(955617..955636) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955629) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 955632..955651 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(955651..955658) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 955655..955762 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 955655..955762 /gene="tswD" /locus_tag="BSU_misc_RNA_11" upshifts 955662 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" downshifts 955793 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" CDS 955895..957667 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" gene 955895..957667 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" downshifts 957643 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" S_feature 957688..958613 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(957705..959060) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" gene complement(957705..959060) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" promotor_-10 complement(959088..959107) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(959105) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" promotor_-35 complement(959121..959130) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 959178..959184 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959199..959218 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959227 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" CDS 959311..959508 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" gene 959311..959508 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" CDS complement(959535..960986) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" gene complement(959535..960986) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" downshifts complement(959545) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" promotor_-35 960963..960969 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960984..961003 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960987 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" promotor_-10 complement(961004..961023) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 961009..961338 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(961023) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" promotor_-35 complement(961037..961044) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(961082..961100) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(961107) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" downshifts 961295 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" CDS 961394..962161 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" gene 961394..962161 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" CDS 962179..963177 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" gene 962179..963177 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" CDS 963174..964004 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" gene 963174..964004 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" CDS 964027..965157 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" gene 964027..965157 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" misc_feature 965184..965203 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 965190 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" CDS 965261..965797 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" gene 965261..965797 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" S_feature 965798..965868 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 965838..965845 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965859..965878 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965870 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" CDS 965909..966178 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" gene 965909..966178 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" promotor_-35 965981..965985 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966008..966024 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966024 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 966165 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" CDS complement(966196..966669) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" gene complement(966196..966669) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" downshifts complement(966232) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" CDS complement(966671..966871) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" gene complement(966671..966871) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" promotor_-10 complement(966900..966919) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966914) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" promotor_-35 complement(966932..966939) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 966995..967000 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967014..967033 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967014 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" tRNA 967065..967138 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 967065..967138 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" S_feature 967139..967321 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(967229..967852) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" gene complement(967229..967852) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" downshifts complement(967244) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" downshifts 967278 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" S_feature 967323..967934 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(967876..967895) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(967897) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" promotor_-35 complement(967909..967916) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 967935..969095 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" gene 967935..969095 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" downshifts 969104 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" misc_feature 969121..969133 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 969126 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" CDS 969162..970097 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" gene 969162..970097 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" downshifts complement(969180) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" promotor_-35 970081..970084 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 970099 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" promotor_-10 970100..970119 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 970135..970617 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" gene 970135..970617 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" downshifts 970600 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" CDS 970667..971383 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" gene 970667..971383 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" promotor_-35 970687..970694 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970709..970728 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970710 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" CDS 971374..972087 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" gene 971374..972087 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" CDS 972099..972806 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" gene 972099..972806 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" downshifts 972690 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" downshifts 972734 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" downshifts 972800 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" S_feature complement(972833..973008) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(972876) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" promotor_-10 complement(973000..973019) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973008) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" promotor_-35 complement(973034..973041) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973073..973078 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973094..973112 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973094 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" CDS 973156..975051 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" gene 973156..975051 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" promotor_no_box 973598..973698 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 973658 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 973724 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" downshifts 975044 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" promotor_-35 975108..975113 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975129..975147 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 975132..975230 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 975132 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" CDS 975231..976409 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" gene 975231..976409 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" promotor_-35 975429..975432 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975447..975466 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975451 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(975692) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" downshifts 976388 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" promotor_-35 976496..976503 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 976518..976537 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976518 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 976569..977033 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" gene 976569..977033 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" promotor_-35 976858..976864 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 976879..976897 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976892 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" promotor_-35 977042..977048 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977062..977073 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977068 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 977069..977734 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" gene 977069..977734 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" CDS 977775..979373 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" gene 977775..979373 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" CDS 979396..979926 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" gene 979396..979926 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" CDS 979939..980313 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" gene 979939..980313 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" downshifts 980302 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" CDS 980313..980468 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" gene 980313..980468 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" promotor_-35 980403..980409 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980424..980443 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980434 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" CDS 980473..981234 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" gene 980473..981234 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" promotor_-10 complement(980786..980804) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980800) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(980820..980825) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 981237..981602 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" gene 981237..981602 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" CDS 981604..982302 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" gene 981604..982302 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" CDS 982319..983236 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" gene 982319..983236 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" CDS 983229..984170 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" gene 983229..984170 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" downshifts 984152 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" CDS complement(984262..984465) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" gene complement(984262..984465) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" downshifts complement(984276) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" S_feature complement(984466..984593) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 984553..984564 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 984570 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(984582..984601) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984593) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" S_feature complement(984595..985733) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(984615..984620) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 984760..984767 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984782..984800 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984789 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" S_feature 984790..984900 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 984901..985731 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" gene 984901..985731 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" downshifts 985690 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" CDS complement(985734..986813) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" gene complement(985734..986813) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" promotor_-10 complement(986823..986842) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(986844) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" promotor_-35 complement(986858..986862) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 986920..986927 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986941..986960 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986947 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" CDS 986986..988377 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" gene 986986..988377 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" S_feature complement(988013..988416) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 988356 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" CDS complement(988417..988872) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" gene complement(988417..988872) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" promotor_-10 complement(988887..988905) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(988915) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" promotor_-35 complement(988920..988926) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988964..988970 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 988984..988995 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 988988 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" CDS 989022..989591 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" gene 989022..989591 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" promotor_-35 989218..989224 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 989235 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 989238..989249 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 989566 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" promotor_-35 989634..989643 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989657..989676 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989667 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" CDS 989712..990680 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" gene 989712..990680 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" downshifts 990556 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" CDS complement(990612..991265) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " gene complement(990612..991265) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" downshifts complement(990629) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(991296..991307) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991298) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" promotor_-35 complement(991322..991328) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 991337..991345 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 991348..995001 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" gene 991348..995001 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" promotor_-10 991356..991374 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991371 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" CDS 994998..995594 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" gene 994998..995594 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" downshifts 995573 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" CDS complement(995624..996532) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" gene complement(995624..996532) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" promotor_-35 996588..996596 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(996589..996600) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996595) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" S_feature complement(996597..997083) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 996607 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" promotor_-10 996610..996629 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(996614..996620) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 996643..997038 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" gene 996643..997038 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" misc_feature complement(997069..997088) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(997083) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" promotor_-35 997123..997129 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 997138 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" promotor_-10 997143..997154 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(997153..997167) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997167) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(997175..997179) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 997175..997597 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" gene 997175..997597 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" promotor_no_box complement(997501..997601) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(997541) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 997575 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" downshifts complement(997607) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" promotor_-35 997647..997654 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997668..997687 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997676 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" CDS 997724..998386 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" gene 997724..998386 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" CDS 998402..999943 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" gene 998402..999943 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" downshifts 999926 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" CDS 1000027..1000218 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" gene 1000027..1000218 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo promotor_-35 1000249..1000256 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 1000271..1000290 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 1000282..1000363 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 1000282 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" CDS 1000364..1001716 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" gene 1000364..1001716 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" CDS 1001744..1002322 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" gene 1001744..1002322 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" promotor_-35 1002317..1002324 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1002339..1002358 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1002350 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" downshifts 1002365 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" S_feature 1002410..1002500 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 1002501..1003325 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" gene 1002501..1003325 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" CDS 1003344..1004834 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" gene 1003344..1004834 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" promotor_-35 1004145..1004151 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 1004166..1004185 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 1004176 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" S_feature 1004835..1004923 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 1004880 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1004886..1004986 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1004946 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" CDS 1004975..1006642 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" gene 1004975..1006642 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" promotor_-35 1006404..1006409 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 1006424..1006442 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 1006433 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" promotor_-35 1006487..1006493 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1006508 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 1006509..1006527 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1006610 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" S_feature 1006655..1006728 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 1006710..1006717 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1006730 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 1006731..1006750 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1006774..1008519 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" gene 1006774..1008519 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" downshifts 1008508 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" S_feature 1008553..1008622 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 1008624..1008643 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1008624 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" CDS 1008668..1009807 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" gene 1008668..1009807 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" CDS 1009804..1010448 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" gene 1009804..1010448 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" CDS 1010445..1010969 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" gene 1010445..1010969 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" downshifts 1010934 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" CDS complement(1010984..1011226) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" gene complement(1010984..1011226) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" downshifts complement(1011005) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" promotor_-10 complement(1011262..1011273) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1011273) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" promotor_-35 complement(1011287..1011294) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1011361..1011367 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1011381..1011392 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011391 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" CDS 1011427..1011750 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" gene 1011427..1011750 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" S_feature 1011751..1013617 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(1011792..1013258) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" gene complement(1011792..1013258) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" downshifts complement(1011804) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1011891) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1013298..1013316) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013310) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" promotor_-35 complement(1013330..1013337) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1013411..1013851) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" gene complement(1013411..1013851) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" downshifts complement(1013441) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" promotor_-35 1013839..1013845 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013859..1013870 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1013861..1013971 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 1013861 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" promotor_-10 complement(1013873..1013892) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013889) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" promotor_-35 complement(1013904..1013910) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1013930 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" CDS complement(1013958..1015616) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" gene complement(1013958..1015616) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" downshifts complement(1013963) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" promotor_-10 complement(1015507..1015525) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015527) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" promotor_-35 complement(1015539..1015545) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1015588..1015593 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1015609..1015627 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1015622 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" CDS 1015647..1017053 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" gene 1015647..1017053 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" downshifts 1017033 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" CDS complement(1017083..1018468) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" gene complement(1017083..1018468) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" downshifts complement(1017109) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" upshifts complement(1018495) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" S_feature complement(1018497..1020028) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(1018505..1018516) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1018624..1018631 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018644..1018663 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1018650..1018937 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 1018650 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" promotor_-35 1018900..1018903 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018918..1018937 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018939 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" CDS 1018998..1020002 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" gene 1018998..1020002 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" downshifts 1019864 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" downshifts 1019994 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" upshifts complement(1020028) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" promotor_-10 complement(1020035..1020050) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1020040 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" promotor_-35 complement(1020062..1020071) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1020073..1020948) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" gene complement(1020073..1020948) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" promotor_-35 1021001..1021002 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1021014..1021033) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 1021019..1021038 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021020) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" upshifts 1021029 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" promotor_-35 complement(1021048..1021053) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 1021057..1022157 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" gene 1021057..1022157 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" promotor_-35 1022168..1022174 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022189..1022207 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022194 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" CDS 1022231..1023100 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" gene 1022231..1023100 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" downshifts 1023108 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" promotor_-35 1023185..1023188 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1023200 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" promotor_-10 1023203..1023222 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 1023248..1023267 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1023253..1023349 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 1023253 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" CDS 1023350..1024747 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" gene 1023350..1024747 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" downshifts 1024727 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" promotor_-35 1024808..1024812 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1024828..1024847 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1024835 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" CDS 1024865..1026220 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" gene 1024865..1026220 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" downshifts 1026201 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" CDS complement(1026255..1027664) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" gene complement(1026255..1027664) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" promotor_-35 1027713..1027716 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1027731..1027750 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1027733 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" promotor_-10 complement(1027735..1027754) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027747) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" promotor_-35 complement(1027770..1027774) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1027774..1028202 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" gene 1027774..1028202 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" downshifts 1028181 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" CDS complement(1028233..1028523) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" gene complement(1028233..1028523) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" downshifts complement(1028257) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" CDS complement(1028511..1029587) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" gene complement(1028511..1029587) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" CDS complement(1029577..1030068) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" gene complement(1029577..1030068) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" S_feature complement(1030069..1030171) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(1030160..1030179) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030171) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" promotor_-35 complement(1030193..1030196) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030209..1030215 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1030226 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" promotor_-10 1030230..1030248 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1030259) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" CDS 1030265..1031260 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" gene 1030265..1031260 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" downshifts 1031239 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1031322..1031325 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031340..1031359 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031345 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" CDS 1031395..1031994 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" gene 1031395..1031994 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" downshifts 1032009 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" S_feature 1032054..1034008 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(1032063..1033397) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" gene complement(1032063..1033397) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" downshifts complement(1032082) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" CDS complement(1033458..1033889) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" gene complement(1033458..1033889) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" promotor_-10 complement(1033901..1033920) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033911) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" promotor_-35 complement(1033935..1033941) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(1033937..1034037) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 1033972..1033979 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(1033977) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1033993..1034012 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 1034010 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" CDS 1034046..1035227 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" gene 1034046..1035227 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" downshifts 1035212 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" S_feature 1035257..1035395 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 1035391..1035410 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1035397..1035553 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 1035397 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" CDS 1035554..1036939 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" gene 1035554..1036939 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" downshifts 1036829 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" downshifts 1036915 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" CDS complement(1036953..1037309) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" gene complement(1036953..1037309) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" CDS complement(1037306..1037701) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" gene complement(1037306..1037701) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" CDS complement(1037688..1038419) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" gene complement(1037688..1038419) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" misc_feature complement(1038444..1038463) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1038465) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" promotor_-35 1038512..1038520 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038529 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" promotor_-10 1038534..1038549 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1038543..1038616 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 1038603..1038604 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038618 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" promotor_-10 1038620..1038639 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1038653..1038760 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" gene 1038653..1038760 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" S_feature 1038761..1038814 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 1038785 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" misc_feature 1038865..1038884 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1038871 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" CDS 1038909..1040024 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" gene 1038909..1040024 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" downshifts 1040004 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" misc_feature 1040061..1040080 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1040061 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" CDS 1040094..1040837 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" gene 1040094..1040837 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" downshifts 1040809 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" CDS complement(1040861..1041709) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" gene complement(1040861..1041709) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" downshifts complement(1040885) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" promotor_-35 1041705..1041710 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1041710..1041809) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 1041726..1041744 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1041728 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" S_feature 1041733..1041928 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(1041798..1041817) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041812) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" promotor_-35 complement(1041832..1041835) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1041927..1041946 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1041930..1041993 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 1041930 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" CDS 1041994..1042842 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" gene 1041994..1042842 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" downshifts 1042833 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" CDS complement(1042885..1044246) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" gene complement(1042885..1044246) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" downshifts complement(1042909) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" S_feature complement(1044247..1044317) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(1044290..1044309) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1044317) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" CDS complement(1044373..1044873) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" gene complement(1044373..1044873) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" downshifts complement(1044405) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(1044895..1044913) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044915) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" promotor_-35 complement(1044928..1044934) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044952..1044959 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1044967..1045036 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 1044968 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" promotor_-10 1044974..1044993 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045037..1045198 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" gene 1045037..1045198 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" downshifts 1045128 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" S_feature 1045199..1045317 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 1045318..1047075 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" gene 1045318..1047075 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" CDS 1047072..1049093 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" gene 1047072..1049093 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" downshifts 1049081 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" CDS complement(1049142..1049762) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" gene complement(1049142..1049762) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" downshifts complement(1049157) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1049747..1049847 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1049776..1049795) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1049791) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" CDS complement(1049801..1049926) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" gene complement(1049801..1049926) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" upshifts 1049807 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1049810..1049813) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1049940..1049959) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1049949) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" promotor_-35 complement(1049973..1049982) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1050005 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" CDS complement(1050031..1050234) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" gene complement(1050031..1050234) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" downshifts complement(1050036) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" S_feature complement(1050235..1050345) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 1050275..1050375 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1050335 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1050351) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" promotor_-10 complement(1050355..1050366) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1050381..1050387) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050443..1050661) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" gene complement(1050443..1050661) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" downshifts complement(1050477) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(1050702..1050721) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050719) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" promotor_-35 complement(1050735..1050742) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050811..1052172) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" gene complement(1050811..1052172) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" downshifts complement(1050829) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" downshifts complement(1050873) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" CDS complement(1052162..1053253) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" gene complement(1052162..1053253) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" promotor_-10 complement(1052577..1052591) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052589) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1052605..1052613) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1053254..1053359) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1053343..1053361) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053363) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" promotor_-35 complement(1053377..1053382) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1053425..1053432 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053447..1053466 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053458 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" CDS 1053520..1054653 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" gene 1053520..1054653 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" S_feature 1054654..1054745 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1054746..1055099 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" gene 1054746..1055099 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" downshifts 1055087 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" CDS complement(1055143..1056216) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" gene complement(1055143..1056216) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" downshifts complement(1055250) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" promotor_-10 complement(1056238..1056257) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1056250) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" promotor_-35 complement(1056271..1056278) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1056353..1056360 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1056373 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" promotor_-10 1056375..1056394 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1056384..1056537 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1056494 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" S_feature 1056539..1056622 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1056579 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" promotor_-35 1056635..1056640 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056656..1056674 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056665 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" CDS 1056702..1057568 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" gene 1056702..1057568 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" downshifts 1057550 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" promotor_-35 1057613..1057616 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057631..1057650 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057639 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" CDS 1057680..1059185 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" gene 1057680..1059185 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" downshifts 1059155 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" CDS complement(1059203..1060420) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" gene complement(1059203..1060420) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" downshifts complement(1059209) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" CDS complement(1060427..1060924) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" gene complement(1060427..1060924) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" CDS complement(1060988..1061326) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" gene complement(1060988..1061326) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" promotor_-10 complement(1061338..1061357) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061362) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" promotor_-35 complement(1061371..1061378) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061398..1061405 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061420..1061439 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061430 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" CDS 1061491..1062258 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" gene 1061491..1062258 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" downshifts 1062259 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" CDS complement(1062279..1062464) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" gene complement(1062279..1062464) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" promotor_-10 complement(1062500..1062518) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062511) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" promotor_-35 complement(1062529..1062537) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1062538..1062541 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1062556..1062575 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1062566 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" CDS 1062591..1063487 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" gene 1062591..1063487 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" CDS 1063480..1064739 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" gene 1063480..1064739 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" downshifts 1064723 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" promotor_-35 1064787..1064794 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1064806..1064825 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1064811 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" CDS 1064846..1066072 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" gene 1064846..1066072 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" downshifts complement(1065547) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" CDS 1066077..1068968 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" gene 1066077..1068968 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" promotor_-35 1067358..1067363 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1067379..1067397 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1067385 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" promotor_-35 1068976..1068981 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068996..1069015 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069011 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" CDS 1069042..1069986 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" gene 1069042..1069986 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" downshifts 1069964 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" promotor_-35 1070045..1070050 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070066..1070084 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070069 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" CDS 1070111..1070323 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" gene 1070111..1070323 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" downshifts 1070316 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" downshifts complement(1070354) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" CDS complement(1070364..1071242) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" gene complement(1070364..1071242) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" downshifts complement(1070552) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" promotor_-10 complement(1071280..1071299) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071304) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" promotor_-35 complement(1071313..1071320) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071340..1071349 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071361 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" promotor_-10 1071362..1071381 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1071398..1071412) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071399) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1071402..1071488 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" gene 1071402..1071488 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" promotor_-35 complement(1071421..1071425) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1071489..1071740 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1071613..1071699 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" gene 1071613..1071699 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" downshifts 1071697 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" S_feature complement(1071709..1071971) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1071742..1072225 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1071752) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1071964..1071983) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071971) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" S_feature complement(1071973..1072041) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1071997..1072002) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1072042..1072560) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" gene complement(1072042..1072560) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" promotor_-35 1072347..1072355 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072367..1072385 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072380 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1072591..1072610) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1072609) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" promotor_-35 complement(1072626..1072632) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1072709..1072712 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072727..1072746 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072732 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" CDS 1072768..1073109 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" gene 1072768..1073109 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" S_feature complement(1072963..1073105) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1073006) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" CDS complement(1073106..1073717) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" gene complement(1073106..1073717) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" S_feature 1073110..1073875 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1073182) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" promotor_-35 1073713..1073717 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1073725..1073738 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1073737 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1073742..1073761) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1073765) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" promotor_-35 complement(1073776..1073779) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1073832 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" CDS complement(1073895..1074251) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" gene complement(1073895..1074251) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" downshifts complement(1073899) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" promotor_-35 1074328..1074333 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1074334..1074353) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1074348) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" promotor_-10 1074349..1074367 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1074349 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" S_feature complement(1074350..1074613) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1074381..1074572 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" gene 1074381..1074572 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" S_feature 1074573..1076008 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1074646..1075164) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" gene complement(1074646..1075164) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" downshifts complement(1074658) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" S_feature complement(1075165..1075252) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1075244..1075263) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075252) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" promotor_-35 complement(1075277..1075284) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1075289..1076368) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" gene complement(1075289..1076368) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" misc_feature complement(1076407..1076426) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1076418) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" S_feature complement(1076420..1076501) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1076515..1076952) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" gene complement(1076515..1076952) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" downshifts complement(1076546) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(1076985..1077004) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076999) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" downshifts 1077002 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" promotor_-35 complement(1077018..1077025) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1077024..1077320) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1077067) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" promotor_-10 complement(1077318..1077329) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1077324) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" promotor_-35 complement(1077344..1077350) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1077380..1077387 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077401..1077420 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077410 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" CDS 1077440..1078183 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" gene 1077440..1078183 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" CDS 1078176..1079402 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" gene 1078176..1079402 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" promotor_-10 complement(1078735..1078753) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1078750) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1078769..1078774) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079422..1080132 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" gene 1079422..1080132 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" downshifts 1080096 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" CDS complement(1080150..1081340) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" gene complement(1080150..1081340) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" downshifts complement(1080160) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1080225) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" promotor_-10 complement(1081364..1081383) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081385) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1081397..1081402) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081413..1082804) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" gene complement(1081413..1082804) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" promotor_-10 complement(1082815..1082834) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1082820) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1082847..1082856) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1082870..1083184) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" gene complement(1082870..1083184) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" CDS complement(1083229..1083729) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" gene complement(1083229..1083729) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" downshifts complement(1083256) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(1083742..1083761) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1083744..1083748 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1083763) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" promotor_-10 1083764..1083783 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083765 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" promotor_-35 complement(1083778..1083779) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1083796..1083802 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1083817..1083828 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083822 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" CDS 1083851..1085995 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" gene 1083851..1085995 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" promotor_-10 complement(1083895..1083906) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1083898) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1083920..1083926) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1086032..1086038 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1086052..1086071 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086062 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" CDS 1086117..1087178 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" gene 1086117..1087178 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" CDS 1087250..1088182 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" gene 1087250..1088182 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" CDS 1088197..1089609 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" gene 1088197..1089609 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" downshifts 1088200 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" downshifts 1089586 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" promotor_-35 1089670..1089677 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1089691..1089710 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1089696 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" CDS 1089755..1090330 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" gene 1089755..1090330 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" promotor_-35 1090074..1090077 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1090092 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" promotor_-10 1090094..1090113 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1090331..1090400 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1090401..1092728 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" gene 1090401..1092728 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" downshifts 1092710 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" CDS complement(1092770..1093747) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" gene complement(1092770..1093747) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" downshifts complement(1092783) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" promotor_-10 complement(1093761..1093780) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093779) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" promotor_-35 complement(1093794..1093800) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1093806..1093814 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093825..1093843 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1093832 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" CDS 1093874..1094650 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" gene 1093874..1094650 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" S_feature complement(1094366..1094987) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1094651..1095022 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1094965..1094984) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094986) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" promotor_-35 complement(1094998..1095007) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1095000..1095007 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1095022..1095041 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1095024 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" CDS 1095063..1096103 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" gene 1095063..1096103 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" CDS 1096116..1096523 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" gene 1096116..1096523 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" downshifts 1096494 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" CDS complement(1096560..1097849) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" gene complement(1096560..1097849) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" downshifts complement(1096590) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" S_feature complement(1097850..1097950) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1097949..1097968) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097950) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" S_feature complement(1097952..1098088) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1097983..1097989) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1098120..1098260) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" gene complement(1098120..1098260) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" downshifts complement(1098133) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" promotor_-10 complement(1098279..1098298) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1098298) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" promotor_-35 complement(1098311..1098318) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1098342..1098348 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098362..1098381 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098365 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" CDS 1098412..1099146 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" gene 1098412..1099146 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" CDS 1099159..1100154 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" gene 1099159..1100154 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" CDS 1100219..1100863 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" gene 1100219..1100863 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" downshifts 1100851 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" promotor_-35 1100891..1100894 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100909..1100928 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100916 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" CDS 1100980..1102521 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" gene 1100980..1102521 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" downshifts 1102501 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" CDS complement(1102560..1102955) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" gene complement(1102560..1102955) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" downshifts complement(1102577) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1102975..1102986) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102979) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" promotor_-35 complement(1103001..1103007) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103040..1103043 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1103051 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" promotor_-10 1103058..1103077 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1103104..1104384 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" gene 1103104..1104384 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" promotor_-10 complement(1103531..1103550) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103545) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1103566..1103571) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1104371 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" downshifts complement(1104421) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" CDS complement(1104423..1105568) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" gene complement(1104423..1105568) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" S_feature complement(1105569..1105635) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1105624..1105643) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1105641) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" promotor_-35 complement(1105659..1105663) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1105948..1105955 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1105970..1105989 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1105972 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" CDS 1106003..1106452 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" gene 1106003..1106452 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" promotor_-35 1106468..1106475 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106490..1106509 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1106497 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" CDS 1106524..1107516 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" gene 1106524..1107516 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" downshifts 1107517 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" S_feature 1107562..1107672 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1107650..1107657 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107673..1107692 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107674 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" CDS 1107733..1108704 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" gene 1107733..1108704 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" downshifts 1108683 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" CDS complement(1108736..1109317) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" gene complement(1108736..1109317) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" downshifts complement(1108759) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1109341..1109360) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109353) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" promotor_-35 complement(1109376..1109379) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1109388..1110482) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" gene complement(1109388..1110482) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" CDS complement(1110479..1111918) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" gene complement(1110479..1111918) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" CDS complement(1111925..1112485) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" gene complement(1111925..1112485) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" misc_feature complement(1111935..1111954) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1111949) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-10 complement(1112510..1112529) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1112524) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-35 complement(1112544..1112551) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1112620..1113918) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" gene complement(1112620..1113918) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" downshifts complement(1112631) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1113972..1113990) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1113975) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" promotor_-35 complement(1114004..1114010) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1114057..1115586) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" gene complement(1114057..1115586) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" promotor_-10 complement(1115613..1115631) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115623) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" promotor_-35 1115642..1115647 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1115646..1115651) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1115659 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" promotor_-10 1115663..1115681 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1115698..1116555 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" gene 1115698..1116555 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" downshifts 1116537 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" CDS complement(1116583..1116816) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" gene complement(1116583..1116816) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" downshifts complement(1116616) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(1116833..1116852) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1116836..1116837 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1116836 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" promotor_-10 1116840..1116855 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116855) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" S_feature complement(1116857..1117712) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1116867..1116874) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117039..1117046 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1117058..1117077 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1117064 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" CDS 1117109..1117687 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" gene 1117109..1117687 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" S_feature 1117688..1117833 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1117734..1118633) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" gene complement(1117734..1118633) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" downshifts complement(1117757) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1117820..1117823 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1117835 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1117841..1117845 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1117879 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" S_feature 1117924..1118790 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1118660..1118678) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118677) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" promotor_-35 complement(1118693..1118699) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118767..1118774 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118789..1118808 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118792 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" CDS 1118850..1119119 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" gene 1118850..1119119 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" downshifts 1119111 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" downshifts complement(1119159) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" CDS complement(1119162..1120631) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" gene complement(1119162..1120631) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" CDS complement(1120628..1120828) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" gene complement(1120628..1120828) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" S_feature complement(1120829..1120947) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1120930..1120949) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1120947) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" promotor_-35 complement(1120962..1120969) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1121035) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" CDS complement(1121036..1121398) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" gene complement(1121036..1121398) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" promotor_-35 1121236..1121241 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1121257..1121275 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1121258 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" S_feature 1121267..1121506 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1121428..1121447) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121446) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" promotor_-35 complement(1121462..1121469) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1121488..1121495 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1121508 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" promotor_-10 1121509..1121528 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1121550..1122173 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" gene 1121550..1122173 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" CDS 1122175..1122681 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" gene 1122175..1122681 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" downshifts 1122674 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" promotor_-35 1122732..1122739 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122753..1122772 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1122762..1122861 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1122762 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" CDS 1122862..1124361 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" gene 1122862..1124361 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" promotor_-35 1124369..1124376 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1124388 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" promotor_-10 1124390..1124409 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1124438..1124965 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" gene 1124438..1124965 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" downshifts 1124927 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" S_feature complement(1124979..1125122) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1125017) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" CDS complement(1125123..1126328) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" gene complement(1125123..1126328) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" promotor_-35 1125818..1125823 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1125840..1125858 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1125843..1126369 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1125844 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" downshifts 1126327 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" CDS complement(1126400..1127452) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" gene complement(1126400..1127452) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" CDS complement(1127466..1128314) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" gene complement(1127466..1128314) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" CDS complement(1128286..1129611) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" gene complement(1128286..1129611) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" promotor_-35 1128455..1128460 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1128476..1128494 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1128482..1129270 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1128482 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" promotor_-35 1129246..1129253 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129268..1129287 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1129272..1129714 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1129272 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" promotor_-10 complement(1129646..1129665) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129658) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" promotor_-35 complement(1129679..1129686) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1129715..1130704 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" gene 1129715..1130704 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" S_feature 1130705..1131082 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1130759..1130917) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1130802) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" CDS complement(1130918..1132072) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" gene complement(1130918..1132072) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" S_feature complement(1132073..1132144) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1132127..1132146) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132143) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" promotor_-35 complement(1132160..1132165) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1132179..1133384) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" gene complement(1132179..1133384) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" misc_feature 1133405..1133424 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1133410 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1133498..1135225 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" gene 1133498..1135225 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" promotor_-35 1134811..1134818 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134833..1134852 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134840 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1135255..1135581) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" gene complement(1135255..1135581) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" CDS complement(1135699..1136136) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" gene complement(1135699..1136136) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" downshifts complement(1135708) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" promotor_-10 complement(1136167..1136186) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1136187) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" promotor_-35 complement(1136199..1136208) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1136256..1136263 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1136277..1136296 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1136289 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" CDS 1136320..1139820 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" gene 1136320..1139820 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" CDS 1139807..1143505 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" gene 1139807..1143505 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" S_feature 1143506..1143576 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1143577..1144752 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " gene 1143577..1144752 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" CDS 1144749..1148141 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" gene 1144749..1148141 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" promotor_-35 1147396..1147402 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1147417..1147428 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1147424 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" S_feature complement(1147493..1148466) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1148155..1148457 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" gene 1148155..1148457 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" downshifts 1148437 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" CDS complement(1148494..1148712) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" gene complement(1148494..1148712) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" downshifts complement(1148511) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" CDS complement(1148744..1149145) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" gene complement(1148744..1149145) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" CDS complement(1149145..1149321) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" gene complement(1149145..1149321) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" CDS complement(1149318..1149935) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" gene complement(1149318..1149935) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" CDS complement(1149958..1150191) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" gene complement(1149958..1150191) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" CDS complement(1150206..1150427) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" gene complement(1150206..1150427) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" S_feature complement(1150428..1150514) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1150442..1150448 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150462..1150481 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1150464..1151119 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1150464 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" promotor_-10 complement(1150501..1150520) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150514) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" S_feature complement(1150516..1150645) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1150533..1150542) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1150647..1150849) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1150690) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" CDS complement(1150850..1151020) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" gene complement(1150850..1151020) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" misc_feature complement(1151064..1151083) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151067) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" S_feature complement(1151069..1151165) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1151076 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" S_feature 1151121..1151285 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1151166..1152089) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" gene complement(1151166..1152089) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" promotor_-10 complement(1152111..1152130) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1152122) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" promotor_-35 complement(1152144..1152153) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1152173..1152181 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1152193..1152211 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1152198 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" CDS 1152244..1153149 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" gene 1152244..1153149 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" S_feature 1153150..1153230 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1153200..1153203 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153220..1153239 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1153232 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" CDS 1153265..1153621 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" gene 1153265..1153621 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" downshifts 1153518 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" downshifts 1153609 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" upshifts 1153742 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" misc_feature 1153745..1153764 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1153789..1156473 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" gene 1153789..1156473 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" downshifts complement(1153957) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" downshifts 1156465 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" CDS complement(1156504..1157091) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" gene complement(1156504..1157091) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" promotor_-10 complement(1157106..1157125) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157125) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" promotor_-35 complement(1157141..1157143) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157146..1157152 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157164 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" promotor_-10 1157167..1157185 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1157170..1157236 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1157237..1159081 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" gene 1157237..1159081 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" S_feature 1159082..1159149 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1159106 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" CDS complement(1159211..1159690) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " gene complement(1159211..1159690) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" upshifts complement(1159710) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" promotor_-10 complement(1159714..1159732) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1159743..1159751) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1159882..1159886 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1159899 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" promotor_-10 1159901..1159920 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1159922..1160746 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" gene 1159922..1160746 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" promotor_-35 1160134..1160140 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160155..1160173 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160162 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1160756..1162206 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1160776..1162143) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" gene complement(1160776..1162143) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" promotor_-35 1162175..1162182 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1162196..1162215 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1162208 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" CDS 1162267..1163130 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" gene 1162267..1163130 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" CDS 1163148..1164161 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" gene 1163148..1164161 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" downshifts 1164144 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" promotor_-35 1164213..1164220 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1164235..1164254 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1164254..1164369 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1164254 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" CDS 1164370..1165398 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" gene 1164370..1165398 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" downshifts 1165420 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" CDS complement(1165449..1165958) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" gene complement(1165449..1165958) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" downshifts complement(1165468) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" promotor_-10 complement(1165971..1165989) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165987) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" promotor_-35 complement(1166001..1166009) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1166008..1166670) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" gene complement(1166008..1166670) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" promotor_-35 1166689..1166695 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166709..1166728 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166718 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" CDS 1166737..1168191 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" gene 1166737..1168191 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" S_feature complement(1168046..1168198) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1168081) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" CDS complement(1168199..1168837) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" gene complement(1168199..1168837) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" S_feature complement(1168838..1168972) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1168886..1168891 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168907..1168925 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168908 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" S_feature 1168918..1169042 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1168958..1168977) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168972) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" promotor_-35 complement(1168992..1168999) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1169043..1169849 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" gene 1169043..1169849 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" downshifts 1169842 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" CDS complement(1169877..1170476) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" gene complement(1169877..1170476) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" downshifts complement(1169896) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" CDS complement(1170473..1171642) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" gene complement(1170473..1171642) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" S_feature complement(1171643..1171754) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1171755..1172465) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" gene complement(1171755..1172465) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" promotor_-10 complement(1172509..1172528) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1172531) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" promotor_-35 complement(1172541..1172550) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1172580..1172589 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172603..1172622 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172614 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" CDS 1172650..1173336 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" gene 1172650..1173336 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" CDS 1173333..1174091 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" gene 1173333..1174091 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" downshifts 1174088 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" CDS complement(1174136..1174765) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" gene complement(1174136..1174765) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" promotor_-10 complement(1174799..1174817) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174816) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" promotor_-35 complement(1174832..1174837) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1174861..1175976) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" gene complement(1174861..1175976) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" downshifts complement(1174890) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" CDS complement(1175985..1177253) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" gene complement(1175985..1177253) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" promotor_-10 complement(1177279..1177290) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177288) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" promotor_-35 complement(1177304..1177310) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1177365..1178213) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" gene complement(1177365..1178213) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" downshifts complement(1177376) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" CDS complement(1178218..1178667) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" gene complement(1178218..1178667) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" promotor_-10 complement(1178688..1178707) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178702) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" promotor_-35 complement(1178723..1178724) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1178757..1180595) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" gene complement(1178757..1180595) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" downshifts complement(1178784) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" downshifts complement(1180677) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" misc_RNA complement(1180685..1180802) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1180685..1180802) /gene="mswK" /locus_tag="BSU_misc_RNA_12" promotor_-10 complement(1180854..1180873) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1180868) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1180888..1180895) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1180909..1181400) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" gene complement(1180909..1181400) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" promotor_-35 1181418..1181421 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1181424..1181443) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1181436..1181455 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181437 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" upshifts complement(1181442) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1181458..1181465) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1181499..1182395 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" gene 1181499..1182395 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" downshifts 1182382 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" CDS complement(1182448..1183032) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" gene complement(1182448..1183032) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" downshifts complement(1182458) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" CDS complement(1183029..1183958) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" gene complement(1183029..1183958) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" misc_feature complement(1183114) /Source="Nicolas_upshift_promotors" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1183116) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" CDS complement(1183943..1184479) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" gene complement(1183943..1184479) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" promotor_-10 complement(1184515..1184534) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184529) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" promotor_-35 complement(1184549..1184552) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1184620..1184627 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1184642..1184661 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1184645 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" CDS 1184657..1185004 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" gene 1184657..1185004 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" CDS 1185001..1185588 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" gene 1185001..1185588 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" CDS 1185608..1185901 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" gene 1185608..1185901 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" downshifts 1185881 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" downshifts 1185925 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" CDS 1186037..1187653 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" gene 1186037..1187653 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" downshifts 1187641 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" CDS complement(1187700..1188551) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" gene complement(1187700..1188551) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" downshifts complement(1187717) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" promotor_-35 1188098..1188105 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188120..1188139 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1188125..1188650 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1188127 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" promotor_-10 complement(1188592..1188611) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188615) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" promotor_-35 1188629..1188634 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1188631) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188649..1188667 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1188652 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" CDS 1188689..1189531 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" gene 1188689..1189531 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" promotor_-35 1189184..1189192 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1189203..1189221 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1189203 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" S_feature 1189532..1189645 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1189646..1190005 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" gene 1189646..1190005 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" downshifts 1189994 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" CDS complement(1190036..1190233) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" gene complement(1190036..1190233) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" downshifts complement(1190049) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" S_feature complement(1190234..1190430) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1190430) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" promotor_-10 complement(1190432..1190443) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1190458..1190464) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1190490..1191302) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" gene complement(1190490..1191302) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" promotor_-10 complement(1191340..1191359) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1191360..1191367 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1191360) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" promotor_-35 complement(1191373..1191380) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191379..1191398 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1191381 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" CDS 1191423..1192190 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" gene 1191423..1192190 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" promotor_-35 1192199..1192205 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1192219 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" promotor_-10 1192220..1192239 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1192254..1192562 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" gene 1192254..1192562 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" downshifts 1192547 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" S_feature 1192592..1192857 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1192858..1194288 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" gene 1192858..1194288 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" CDS 1194333..1194827 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" gene 1194333..1194827 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" downshifts 1194791 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" promotor_-35 1194965..1194972 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1194971 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" promotor_-10 1194986..1195005 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1195034..1196071 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" gene 1195034..1196071 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" CDS 1196091..1197311 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" gene 1196091..1197311 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" CDS 1197326..1198102 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" gene 1197326..1198102 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" CDS 1198099..1199256 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" gene 1198099..1199256 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" CDS 1199327..1200388 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQ PYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMT SQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEW IFDDYLKNVIPARREIAHA*" gene 1199327..1200388 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" misc_feature complement(1200222..1200241) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1200232) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1200381..1203473 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" gene 1200381..1203473 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" CDS 1203461..1204420 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" gene 1203461..1204420 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" downshifts 1204383 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" S_feature complement(1204423..1204697) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1204448..1204454 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1204456) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" promotor_-10 1204469..1204480 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1204490 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" CDS 1204506..1204685 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" gene 1204506..1204685 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" downshifts 1204695 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" CDS complement(1204731..1204916) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" gene complement(1204731..1204916) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" downshifts complement(1204742) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" promotor_-10 complement(1204945..1204964) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1204962) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" promotor_-35 complement(1204975..1204982) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1205017..1205023 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205035..1205054 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205040 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1205097..1205106 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1205106 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" promotor_-10 1205119..1205138 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1205165..1205899 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" gene 1205165..1205899 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" S_feature complement(1205658..1206260) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1205880..1205885 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1205898 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" upshifts 1205898 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" promotor_-10 1205901..1205919 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1205981..1206538 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" gene 1205981..1206538 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" promotor_-10 complement(1206240..1206259) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206260) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" promotor_-35 complement(1206274..1206278) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1206545..1206552 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1206567..1206586 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1206579 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" CDS 1206629..1207582 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" gene 1206629..1207582 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" promotor_-35 1207246..1207250 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1207266..1207285 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1207279 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" CDS 1207597..1207788 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" gene 1207597..1207788 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" downshifts 1207767 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" S_feature 1207812..1208152 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1207818..1208057) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" gene complement(1207818..1208057) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" downshifts complement(1207834) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" promotor_-10 complement(1208070..1208089) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1208091) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" promotor_-35 complement(1208103..1208112) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1208118..1208125 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1208140..1208159 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1208154 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" CDS 1208222..1209160 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" gene 1208222..1209160 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" promotor_-35 1208299..1208308 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1208317 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" promotor_-10 1208320..1208335 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1209183..1210424 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" gene 1209183..1210424 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" promotor_-10 complement(1209397..1209415) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209405) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1209431..1209436) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1210275 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" downshifts 1210408 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" promotor_-35 1210449..1210458 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1210471..1210490 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1210473 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" promotor_-35 1210485..1210493 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1210500..1211285 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" gene 1210500..1211285 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" promotor_-10 1210505..1210523 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210517 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1211286..1211370 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1211302..1211320) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1211319) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1211335..1211340) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1211338..1211345 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211360..1211379 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1211372..1211476 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1211372 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1211477..1212463 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" gene 1211477..1212463 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" CDS 1212460..1213449 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" gene 1212460..1213449 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" misc_feature 1213455..1213461 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1213460..1213536 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1213460 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1213537..1214028 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" gene 1213537..1214028 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo CDS 1214001..1215167 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" gene 1214001..1215167 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo downshifts 1215158 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" CDS 1215243..1216193 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" gene 1215243..1216193 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" CDS 1216210..1217121 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" gene 1216210..1217121 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" downshifts 1217135 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" S_feature 1217180..1217287 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1217260..1217265 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217281..1217299 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217289 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" CDS 1217326..1218078 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" gene 1217326..1218078 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" downshifts 1218058 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" CDS complement(1218113..1219105) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" gene complement(1218113..1219105) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" downshifts complement(1218134) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" misc_RNA complement(1219164..1219378) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene complement(1219164..1219378) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" downshifts complement(1219212) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" misc_feature complement(1219397..1219416) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1219410) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" promotor_-35 1219665..1219672 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1219686..1219848 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1219687..1219706 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219687 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" CDS 1219849..1221486 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" gene 1219849..1221486 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" downshifts 1221380 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" S_feature 1221487..1221593 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1221594..1222529 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" gene 1221594..1222529 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" promotor_-10 complement(1221637..1221656) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221654) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1221672..1221678) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1222533..1223450 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" gene 1222533..1223450 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" CDS 1223455..1224531 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" gene 1223455..1224531 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" CDS 1224533..1225450 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" gene 1224533..1225450 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" downshifts 1225420 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" promotor_-35 1225500..1225503 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1225516 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1225518..1225537 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1225557..1226774 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" gene 1225557..1226774 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" promotor_-35 1226827..1226836 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1226849..1226864 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1226858..1226937 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1226858 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" CDS 1226938..1227516 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" gene 1226938..1227516 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" S_feature 1227517..1227631 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1227568..1227587) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227572) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1227601..1227608) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1227634..1227647 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1227634 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" CDS 1227697..1228092 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" gene 1227697..1228092 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" promotor_no_box complement(1227928..1228028) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1227968) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1228090 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" S_feature 1228135..1228924 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1228135..1228791) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" gene complement(1228135..1228791) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" promotor_-10 complement(1228821..1228839) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1228836) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" promotor_-35 complement(1228854..1228859) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1228897..1228904 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228918..1228937 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1228926..1229067 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1228926 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" CDS 1228961..1229101 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" gene 1228961..1229101 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" CDS 1229068..1229724 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" gene 1229068..1229724 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" downshifts 1229714 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" CDS complement(1229719..1229841) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" gene complement(1229719..1229841) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" S_feature 1229759..1229848 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1229827..1229835 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229846..1229864 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1229850..1229914 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1229850 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" CDS 1229915..1231036 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" gene 1229915..1231036 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" promotor_-35 1230690..1230696 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1230708 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" promotor_-10 1230711..1230729 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1230922..1230930 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1230942..1230960 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1230949 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" promotor_-35 1231030..1231036 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1231051..1231062 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1231060 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" CDS 1231083..1233095 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" gene 1231083..1233095 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" promotor_-35 1231158..1231165 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1231180..1231199 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1231192 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" downshifts 1233042 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" S_feature 1233096..1233397 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1233133..1233300) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" gene complement(1233133..1233300) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" downshifts complement(1233146) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(1233320..1233338) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233336) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" promotor_-35 complement(1233354..1233359) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1233390..1233397 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1233399..1233524 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1233399 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" misc_RNA 1233405..1233543 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" gene 1233405..1233543 /gene="roxS" /locus_tag="BSU_misc_RNA_67" promotor_-10 1233412..1233431 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1233481 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" CDS complement(1233614..1234513) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" gene complement(1233614..1234513) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" downshifts complement(1233645) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1233849..1233854 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1233861 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" promotor_-10 1233870..1233888 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1233877..1235778 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1234510..1234908) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" gene complement(1234510..1234908) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" S_feature complement(1234909..1235088) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1235080..1235099) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1235088) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" promotor_-35 complement(1235111..1235118) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1235163..1235708) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" gene complement(1235163..1235708) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" downshifts complement(1235187) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" S_feature complement(1235709..1235911) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1235912..1236484) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" gene complement(1235912..1236484) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" promotor_-10 complement(1236057..1236075) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1236066) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 complement(1236088..1236095) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1236513..1236532) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1236530) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 1236546..1236549 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1236547..1236554) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1236562 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" promotor_-10 1236565..1236584 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1236609..1236977 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" gene 1236609..1236977 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" CDS 1237006..1237641 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" gene 1237006..1237641 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" CDS 1237660..1238460 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" gene 1237660..1238460 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" CDS 1238523..1239374 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" gene 1238523..1239374 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" downshifts 1239333 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" CDS complement(1239387..1240121) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" gene complement(1239387..1240121) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" downshifts complement(1239409) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" promotor_-35 1240243..1240247 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1240264..1240283 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1240278 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" S_feature 1240279..1240355 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1240356..1242200 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" gene 1240356..1242200 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" misc_feature complement(1240683..1240702) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1240707) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1242202..1242209 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1242223..1242242 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1242229 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" misc_RNA 1242262..1242370 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1242262..1242370 /gene="tswA" /locus_tag="BSU_misc_RNA_14" downshifts 1242365 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" CDS 1242449..1243159 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" gene 1242449..1243159 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" CDS 1243134..1243751 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" gene 1243134..1243751 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" CDS 1243735..1244844 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" gene 1243735..1244844 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" CDS 1244844..1245044 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" gene 1244844..1245044 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" CDS 1245041..1245811 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" gene 1245041..1245811 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" CDS 1245808..1246818 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" gene 1245808..1246818 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" CDS 1246837..1247652 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" gene 1246837..1247652 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" downshifts 1247626 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1247699..1247705 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247718..1247737 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1247728 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" CDS 1247788..1248564 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" gene 1247788..1248564 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" downshifts 1248553 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" promotor_-35 1248612..1248617 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248633..1248651 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248637 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" promotor_-10 complement(1248649..1248663) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248649) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1248665..1249348 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" gene 1248665..1249348 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" promotor_-35 complement(1248671..1248675) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1249343 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" downshifts 1249431 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" CDS complement(1249442..1249888) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" gene complement(1249442..1249888) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" downshifts complement(1249463) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" S_feature complement(1249889..1250015) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1250016..1250504) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" gene complement(1250016..1250504) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" promotor_-35 1250184..1250190 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250205..1250224 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250223 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1250500..1250504 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250513..1250527 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250531 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1250541..1250560) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250558) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1250574..1250583) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1250590..1250608) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250607) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1250624..1250629) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1250641 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" CDS complement(1250656..1251174) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" gene complement(1250656..1251174) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" downshifts complement(1250680) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" downshifts 1250685 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" S_feature complement(1251175..1251272) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1251273..1251590) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" gene complement(1251273..1251590) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" CDS complement(1251631..1252017) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" gene complement(1251631..1252017) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" promotor_-35 1252013..1252017 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1252025..1252039 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1252027 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1252037..1252056) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252059) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" S_feature complement(1252061..1252565) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 complement(1252075) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1252114..1252119 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1252135..1252153 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1252137 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" CDS 1252177..1252533 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" gene 1252177..1252533 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" promotor_-35 1252543..1252552 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1252550..1252569) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1252558..1252791) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" gene complement(1252558..1252791) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo upshifts complement(1252565) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" S_feature 1252566..1252752 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1252566..1252583 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1252566 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" promotor_-35 complement(1252583..1252592) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1252609) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" downshifts 1252709 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" upshifts complement(1252763) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1252764..1252773 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1252771..1252778) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1252787..1252806 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1252797 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" CDS 1252815..1253021 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" gene 1252815..1253021 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" CDS 1252858..1253073 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" gene 1252858..1253073 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" promotor_-35 1253045..1253054 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253067..1253086 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253072 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" promotor_-10 complement(1253079..1253093) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253093) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1253103..1253107) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1253103..1253252 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" gene 1253103..1253252 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" downshifts 1253193 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" S_feature 1253253..1253384 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1253385..1253639 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" gene 1253385..1253639 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" downshifts 1253624 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" downshifts complement(1253643) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" S_feature 1253669..1254769 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1253713..1255992) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" gene complement(1253713..1255992) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" downshifts complement(1253731) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" S_feature complement(1255867..1256041) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1255920..1255928 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255939..1255957 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1255943..1256078 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1255943 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" promotor_-10 complement(1256029..1256048) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1256040) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" promotor_-35 1256056..1256062 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1256064..1256068) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256077..1256095 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256080 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" CDS 1256109..1256363 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" gene 1256109..1256363 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" downshifts 1256339 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" downshifts complement(1256429) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" CDS complement(1256436..1256858) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" gene complement(1256436..1256858) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" CDS complement(1256862..1257377) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" gene complement(1256862..1257377) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" CDS complement(1257414..1258136) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" gene complement(1257414..1258136) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" misc_feature complement(1258175..1258194) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1258196) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" promotor_-35 1258245..1258252 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258267..1258286 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258271 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" misc_RNA 1258304..1258424 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 1258304..1258424 /gene="mswA" /locus_tag="BSU_misc_RNA_15" downshifts 1258429 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" CDS 1258492..1259613 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" gene 1258492..1259613 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" CDS 1259606..1260778 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" gene 1259606..1260778 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" downshifts 1260761 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" misc_feature 1260795..1260813 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1260805 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" S_feature 1260806..1262335 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1260811..1261356) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" gene complement(1260811..1261356) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" downshifts complement(1260832) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" CDS complement(1261426..1262616) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" gene complement(1261426..1262616) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" promotor_-10 complement(1262642..1262661) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262646) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" promotor_-35 complement(1262676..1262683) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1262710..1262717 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1262721 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" promotor_-10 1262731..1262750 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1262789..1262861 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 1262789..1262861 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" promotor_-10 complement(1262803..1262820) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262817) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1262841..1262847) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1262851 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" S_feature complement(1262876..1263611) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1262896..1264544 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1262905) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" S_feature complement(1263613..1263701) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1263656) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" CDS complement(1263702..1264931) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" gene complement(1263702..1264931) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" downshifts complement(1263824) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" downshifts 1264501 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" S_feature complement(1264932..1265017) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1264972..1264979 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264994..1265013 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1265003..1265022) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265007 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" upshifts complement(1265021) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" promotor_-35 complement(1265035..1265041) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265057..1265377 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" gene 1265057..1265377 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" downshifts 1265387 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" S_feature 1265432..1265529 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1265530..1265661 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " gene 1265530..1265661 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" CDS 1265677..1265850 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" gene 1265677..1265850 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" CDS 1265887..1266348 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" gene 1265887..1266348 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" promotor_-35 1266319..1266326 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1266341..1266360 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1266349..1266589 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1266349 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" promotor_-35 1266562..1266569 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266583..1266601 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1266591 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" CDS 1266614..1267117 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" gene 1266614..1267117 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" CDS 1267129..1267413 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" gene 1267129..1267413 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" downshifts 1267383 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" upshifts complement(1267415) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1267426..1267429) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1267574..1268101 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" gene 1267574..1268101 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" promotor_-35 1268248..1268253 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268266..1268285 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268269 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" CDS 1268275..1268592 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" gene 1268275..1268592 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" S_feature 1268593..1268828 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1268829..1269584 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" gene 1268829..1269584 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" S_feature 1269585..1269672 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1269629 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" S_feature complement(1269672..1269732) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1269703) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" CDS complement(1269733..1270080) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" gene complement(1269733..1270080) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" promotor_-10 complement(1270112..1270130) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270125) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" S_feature complement(1270127..1270583) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1270141..1270149) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1270543..1270561 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1270555 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" promotor_-10 complement(1270561..1270580) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270583) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" promotor_-35 complement(1270594..1270601) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1270631..1272577 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" gene 1270631..1272577 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" downshifts 1272553 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" promotor_-35 1272653..1272656 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272672..1272691 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" upshifts complement(1272695) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1272704..1272718) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1272725..1274677 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" gene 1272725..1274677 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" CDS 1274692..1275639 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" gene 1274692..1275639 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" S_feature 1275640..1275738 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1275713..1275719 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275734..1275753 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1275740..1275808 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1275740 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" CDS 1275809..1276291 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" gene 1275809..1276291 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" downshifts 1276271 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" CDS complement(1276337..1276843) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" gene complement(1276337..1276843) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" downshifts complement(1276361) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" misc_feature complement(1276868..1276887) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1276874) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" S_feature complement(1276876..1277061) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1277062..1277457) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" gene complement(1277062..1277457) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" promotor_-10 complement(1277480..1277498) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1277493) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" S_feature complement(1277495..1278195) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1277513..1277518) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1277601..1277608 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277622..1277641 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1277633 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" CDS 1277686..1278165 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " gene 1277686..1278165 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" downshifts 1278164 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" CDS complement(1278205..1278399) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" gene complement(1278205..1278399) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" downshifts complement(1278240) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" promotor_-10 complement(1278413..1278428) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278429) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" promotor_-35 complement(1278440..1278449) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1278565..1278894) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" gene complement(1278565..1278894) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" promotor_-10 complement(1278931..1278950) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278944) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" S_feature complement(1278946..1279513) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1278965..1278970) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1278998..1279002 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279018..1279037 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1279022..1279523 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1279022 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" CDS complement(1279514..1280503) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" gene complement(1279514..1280503) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" promotor_-10 complement(1280504..1280523) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1280507) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" promotor_-35 complement(1280537..1280542) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1280626..1280874) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" gene complement(1280626..1280874) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" downshifts complement(1280636) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" promotor_-35 1280870..1280874 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280883..1280897 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1280892 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1280899..1280918) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1280908) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" promotor_-35 complement(1280932..1280941) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1280989..1280996 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1281003..1281022) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1281010..1281029 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281012) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" upshifts 1281023 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" S_feature 1281024..1281127 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1281036..1281043) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1281128..1282531 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" gene 1281128..1282531 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" downshifts 1282520 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" CDS complement(1282571..1283044) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" gene complement(1282571..1283044) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" downshifts complement(1282575) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1283066..1283084) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283084) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1283099..1283104) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283169..1283336) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" gene complement(1283169..1283336) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" downshifts complement(1283172) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" promotor_-10 complement(1283348..1283366) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283357) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1283379..1283386) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1283463..1284362 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" gene 1283463..1284362 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" CDS complement(1284371..1284769) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" gene complement(1284371..1284769) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" downshifts complement(1284401) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" promotor_-10 complement(1284798..1284817) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284817) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1284832..1284839) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1284870..1285445) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" gene complement(1284870..1285445) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" downshifts complement(1284885) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" promotor_-10 complement(1285464..1285482) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285479) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1285496..1285502) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1285520..1285526 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285541..1285559 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285542 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" CDS 1285591..1288548 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" gene 1285591..1288548 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" CDS 1288541..1289101 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" gene 1288541..1289101 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" downshifts 1289094 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" S_feature 1289139..1289257 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1289235..1289238 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289254..1289273 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289259 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" CDS 1289298..1289939 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" gene 1289298..1289939 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" downshifts complement(1289307) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" downshifts 1289912 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" CDS 1290018..1290644 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" gene 1290018..1290644 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" downshifts 1290646 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" downshifts complement(1290649) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" CDS complement(1290675..1290953) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" gene complement(1290675..1290953) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" downshifts complement(1290693) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1290982..1290993) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1290995..1291001) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1291001) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" S_feature complement(1291003..1291419) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1291171 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" misc_feature 1291172..1291191 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1291189..1291343 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1291344..1292534 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" gene 1291344..1292534 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" promotor_-10 complement(1291417..1291436) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291419) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" promotor_-35 complement(1291450..1291459) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1292557..1293735 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" gene 1292557..1293735 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" CDS complement(1293776..1293964) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" gene complement(1293776..1293964) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" downshifts complement(1293792) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(1293990..1294009) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293993) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" promotor_-35 complement(1294023..1294029) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294051..1294058 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294073..1294092 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294084 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" promotor_-10 complement(1294099..1294118) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294103) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1294133..1294140) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1294138..1294950 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" gene 1294138..1294950 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" downshifts 1294929 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" CDS complement(1294996..1295748) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" gene complement(1294996..1295748) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" downshifts complement(1295005) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" CDS complement(1295748..1296500) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" gene complement(1295748..1296500) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" CDS complement(1296620..1297594) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" gene complement(1296620..1297594) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" downshifts complement(1296655) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1297615..1297634) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297641) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" S_feature complement(1297643..1300149) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1297649..1297656) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297677..1297683 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297698..1297716 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297701 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" CDS 1297726..1298223 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" gene 1297726..1298223 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" S_feature 1298224..1298337 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1298317..1298321 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298337..1298356 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1298339..1298611 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1298339 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" CDS 1298612..1299034 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" gene 1298612..1299034 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" CDS 1299074..1300252 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" gene 1299074..1300252 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" promotor_no_box 1300083..1300183 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1300141..1300159) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300143 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1300149) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" promotor_-35 complement(1300171..1300179) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1300251 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" promotor_-35 1300360..1300367 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300382..1300401 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300407 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" CDS 1300450..1301871 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" gene 1300450..1301871 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" CDS 1301939..1303318 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" gene 1301939..1303318 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" promotor_-10 complement(1302458..1302477) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1302463) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1302491..1302498) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1303343 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" misc_feature 1303353..1303360 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1303355..1303422 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1303423..1304436 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" gene 1303423..1304436 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" CDS 1304442..1305461 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" gene 1304442..1305461 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" CDS 1305486..1306565 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" gene 1305486..1306565 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" CDS 1306562..1307398 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" gene 1306562..1307398 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" CDS 1307446..1308714 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" gene 1307446..1308714 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" promotor_-35 1308658..1308661 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308677..1308681 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308679 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" misc_feature 1308747..1308766 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1308747 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" CDS 1308802..1309803 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " gene 1308802..1309803 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" promotor_no_box complement(1309485..1309585) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1309525) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1309779 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" CDS 1309880..1311322 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" gene 1309880..1311322 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" CDS 1311319..1312812 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" gene 1311319..1312812 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" CDS complement(1312851..1313615) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGSIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" gene complement(1312851..1313615) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" downshifts complement(1312870) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" SCAR join(1313642,1313649) /created_by="User" /modified_by="User" /label="TF8A" N_region 1313643..1313648 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1313651..1313971 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1313651..1313971 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1313980 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" S_feature complement(1313989..1314192) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1314008..1314145) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" gene complement(1314008..1314145) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" downshifts complement(1314032) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" CDS complement(1314231..1314401) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" gene complement(1314231..1314401) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" downshifts complement(1314237) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" CDS complement(1314401..1315147) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" gene complement(1314401..1315147) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" promotor_-10 complement(1314982..1315001) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1314999) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1315017..1315024) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1315173..1315191) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315186) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1315207..1315212) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1315257..1316258) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " gene complement(1315257..1316258) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" downshifts complement(1315286) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" CDS complement(1316271..1316888) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" gene complement(1316271..1316888) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" promotor_-10 complement(1316924..1316943) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316926) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" S_feature complement(1316928..1317025) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1316959..1316963) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1317005..1317024) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1317025) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" promotor_-35 complement(1317039..1317046) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1317070..1317089) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1317082) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" CDS complement(1317164..1318480) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" gene complement(1317164..1318480) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" downshifts complement(1317179) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1318527..1318546) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1318543) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" promotor_-35 complement(1318561..1318564) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1318763..1318770 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1318785..1318804 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1318797..1318868 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1318797 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" CDS 1318869..1319819 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" gene 1318869..1319819 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" downshifts 1319807 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" CDS 1319920..1320066 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" gene 1319920..1320066 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" CDS 1320074..1322224 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" gene 1320074..1322224 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" promotor_no_box 1320963..1321063 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1321023 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1321111 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" CDS 1322236..1323207 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" gene 1322236..1323207 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" S_feature complement(1322564..1323205) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1323250) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" S_feature complement(1323275..1323641) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1323318) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" promotor_-10 complement(1323621..1323636) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323641) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" promotor_-35 complement(1323648..1323657) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1323725..1325074) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " gene complement(1323725..1325074) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" downshifts complement(1323739) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" promotor_-35 1325114..1325121 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1325126..1325145) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325134 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" promotor_-10 1325136..1325155 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1325144) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" S_feature complement(1325146..1325228) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1325156..1325163) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1325185..1325191 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325206..1325225 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325209 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" promotor_-10 complement(1325211..1325230) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1325228) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" CDS 1325243..1326061 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" gene 1325243..1326061 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" promotor_-35 complement(1325246..1325249) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1326039 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" promotor_-35 1326118..1326125 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326140..1326159 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326144 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1326190..1327014 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" gene 1326190..1327014 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" CDS 1327031..1327957 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" gene 1327031..1327957 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" CDS 1327963..1328925 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" gene 1327963..1328925 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" promotor_-35 1328657..1328662 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328678..1328696 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328679 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1328930..1329937 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" gene 1328930..1329937 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" CDS 1329940..1331589 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" gene 1329940..1331589 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" downshifts 1331583 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" CDS 1331677..1332636 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" gene 1331677..1332636 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" CDS 1332633..1333733 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" gene 1332633..1333733 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" CDS 1333730..1334620 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" gene 1333730..1334620 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" CDS 1334633..1335622 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" gene 1334633..1335622 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" S_feature complement(1334916..1335643) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1335612 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" S_feature 1335657..1336825 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1335665..1336714) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" gene complement(1335665..1336714) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" downshifts complement(1335688) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1336741..1336760) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336752) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" promotor_-35 complement(1336775..1336782) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1336804..1337664) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" gene complement(1336804..1337664) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" promotor_-10 complement(1337689..1337707) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337706) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" promotor_-35 complement(1337723..1337729) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337738..1337745 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1337759..1337778 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337766 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" CDS 1337824..1338342 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" gene 1337824..1338342 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" downshifts 1338333 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" promotor_-35 1338407..1338413 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1338425..1338531 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1338425 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" promotor_-10 1338427..1338438 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1338506..1338509 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338525..1338544 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338533 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" CDS 1338581..1339780 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" gene 1338581..1339780 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" downshifts 1339769 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" S_feature 1339814..1340185 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1339857..1340081) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" gene complement(1339857..1340081) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" promotor_-35 1340161..1340167 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340181..1340192 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1340187 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" CDS 1340226..1340957 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" gene 1340226..1340957 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" downshifts 1340935 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" promotor_-35 1340996..1341004 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341015..1341033 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341023 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" CDS 1341049..1341576 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" gene 1341049..1341576 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" CDS 1341566..1342084 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" gene 1341566..1342084 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" promotor_-35 1342078..1342085 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1342099..1342118 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1342102 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" misc_RNA 1342117..1342228 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" gene 1342117..1342228 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" downshifts 1342191 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" CDS 1342306..1342644 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" gene 1342306..1342644 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" CDS 1342644..1342961 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" gene 1342644..1342961 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" promotor_-35 1342961..1342964 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342980..1342999 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342992 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" CDS 1343032..1343934 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" gene 1343032..1343934 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" downshifts 1343925 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" promotor_-35 1343981..1343987 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1343993 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" promotor_-10 1344001..1344020 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1344022..1344232 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" gene 1344022..1344232 /gene="pswB" /locus_tag="BSU_misc_RNA_17" downshifts 1344190 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" CDS 1344285..1345382 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" gene 1344285..1345382 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" promotor_-35 1344472..1344474 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344476..1344480 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344476 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" CDS 1345394..1346641 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" gene 1345394..1346641 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" downshifts 1346632 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" promotor_-35 1346703..1346710 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346725..1346744 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346734 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" CDS 1346767..1347192 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" gene 1346767..1347192 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" downshifts 1347181 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" CDS complement(1347223..1347666) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" gene complement(1347223..1347666) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" downshifts complement(1347257) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1347693..1347712) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347699) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" promotor_-35 complement(1347727..1347730) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1347748..1347754 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347768..1347786 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347774 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" CDS 1347809..1348219 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" gene 1347809..1348219 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" downshifts 1348197 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" CDS 1348246..1348416 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" gene 1348246..1348416 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" S_feature 1348417..1349094 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1348466..1348936) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" gene complement(1348466..1348936) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" downshifts complement(1348490) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1348958..1348977) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1348974) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" S_feature complement(1348976..1349083) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1348993..1348996) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1349052 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" CDS complement(1349109..1351397) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" gene complement(1349109..1351397) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" downshifts complement(1349128) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" S_feature complement(1351398..1351460) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1351420..1351520) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1351460) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" misc_RNA complement(1351525..1351680) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" gene complement(1351525..1351680) /gene="mswB" /locus_tag="BSU_misc_RNA_18" downshifts complement(1351526) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1351713..1351732) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1351725) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" S_feature complement(1351727..1351812) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1351748..1351755) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1351813..1352772) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" gene complement(1351813..1352772) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" S_feature complement(1352773..1352824) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1352817..1352836) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1352829) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" promotor_-35 complement(1352850..1352856) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1352941..1352944 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1352957 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" promotor_-10 1352960..1352979 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1352995..1353828 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" gene 1352995..1353828 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" downshifts 1353804 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" CDS complement(1353859..1354623) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" gene complement(1353859..1354623) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" downshifts complement(1353880) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" CDS complement(1354598..1356241) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" gene complement(1354598..1356241) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" CDS complement(1356228..1356827) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" gene complement(1356228..1356827) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" CDS complement(1356829..1357431) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" gene complement(1356829..1357431) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" downshifts complement(1357509) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" misc_RNA complement(1357528..1357640) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene complement(1357528..1357640) /gene="tswB" /locus_tag="BSU_misc_RNA_19" promotor_-35 1357641..1357644 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1357655..1357674) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1357660..1357679 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357671 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1357676) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" promotor_-35 complement(1357689..1357696) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1357742..1358428 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" gene 1357742..1358428 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" CDS 1358432..1359796 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" gene 1358432..1359796 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" CDS 1359793..1360473 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" gene 1359793..1360473 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" promotor_-35 1360502..1360507 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360523..1360541 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360526 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" CDS 1360565..1361077 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" gene 1360565..1361077 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" downshifts 1361063 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" promotor_-35 1361108..1361114 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361128..1361139 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361129 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" CDS 1361160..1361297 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" gene 1361160..1361297 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" downshifts 1361270 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" promotor_-35 1361356..1361363 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361377..1361396 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1361379..1361698 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1361379 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" misc_RNA 1361411..1361564 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1361411..1361564 /gene="swmG" /locus_tag="BSU_misc_RNA_68" promotor_-35 1361676..1361685 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361698..1361717 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1361700..1361801 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1361700 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" CDS 1361802..1363157 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" gene 1361802..1363157 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" downshifts 1363148 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" CDS complement(1363200..1363532) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" gene complement(1363200..1363532) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" promotor_-10 complement(1363548..1363567) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363558) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" S_feature complement(1363560..1363948) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1363583..1363588) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1363620..1363720 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1363680 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" CDS 1363727..1363882 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" gene 1363727..1363882 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" promotor_-35 1363891..1363898 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363905..1363922 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363922 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" promotor_-10 complement(1363933..1363952) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363948) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" promotor_-35 complement(1363966..1363972) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1363970..1364152 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" gene 1363970..1364152 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" downshifts 1364120 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" promotor_-35 1364177..1364185 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1364196..1364214 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1364202..1364284 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1364202 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" CDS 1364285..1364749 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" gene 1364285..1364749 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" downshifts 1364734 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" CDS complement(1364764..1365885) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" gene complement(1364764..1365885) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" promotor_-35 1365173..1365181 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365195..1365214 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1365198..1365976 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1365198 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" promotor_-10 complement(1365914..1365925) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365934) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1365940..1365946) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1365977..1366528 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" gene 1365977..1366528 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" downshifts 1366496 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" CDS complement(1366556..1367368) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" gene complement(1366556..1367368) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" promotor_-10 complement(1367328..1367347) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367342) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1367361..1367366) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1367469..1367475 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1367486..1367560 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1367486 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" promotor_-10 1367489..1367500 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1367561..1369255 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" gene 1367561..1369255 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" CDS 1369268..1370281 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" gene 1369268..1370281 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" downshifts 1370266 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" CDS complement(1370307..1372142) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" gene complement(1370307..1372142) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" downshifts complement(1370356) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" CDS complement(1372146..1373081) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" gene complement(1372146..1373081) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" promotor_-10 complement(1373052..1373063) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373062) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" promotor_-35 complement(1373078..1373084) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1373118..1375520) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" gene complement(1373118..1375520) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" downshifts complement(1373150) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" S_feature complement(1375368..1375570) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1375559..1375577) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375570) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" promotor_-35 complement(1375591..1375598) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375637..1375644 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375658..1375677 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375670 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" CDS 1375701..1376366 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" gene 1375701..1376366 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" promotor_-10 complement(1376235..1376254) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376252) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1376268..1376277) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1376361..1376368 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376383..1376402 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376396 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" misc_RNA 1376422..1376555 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1376422..1376555 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" CDS 1376443..1377417 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" gene 1376443..1377417 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" downshifts 1376506 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" downshifts 1377405 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1377527..1377535 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1377549..1377557 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1377559 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" S_feature 1377562..1377648 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1377621..1377628 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1377642..1377661 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1377650 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" CDS 1377681..1378436 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" gene 1377681..1378436 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" CDS 1378433..1379578 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" gene 1378433..1379578 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" S_feature 1379579..1380738 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1379589..1379783) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" gene complement(1379589..1379783) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" downshifts complement(1379596) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1379826..1379837) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379836) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" promotor_-35 complement(1379852..1379858) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1379914..1380615) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" gene complement(1379914..1380615) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" downshifts complement(1379948) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" S_feature complement(1380616..1380696) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1380688..1380707) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1380696) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" promotor_-35 1380712..1380719 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1380721..1380728) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380733..1380752 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380740 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" CDS 1380786..1381682 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" gene 1380786..1381682 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" downshifts 1381676 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" promotor_-35 1381787..1381791 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381807..1381826 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381811 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" CDS 1381856..1383205 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " gene 1381856..1383205 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" downshifts 1383193 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1383254..1383260 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383274..1383285 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1383282..1383349 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1383282 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" CDS 1383350..1383505 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" gene 1383350..1383505 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" CDS 1383508..1383684 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" gene 1383508..1383684 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" promotor_no_box 1383574..1383674 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1383634 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1383680 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" CDS complement(1383727..1384749) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" gene complement(1383727..1384749) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" downshifts complement(1383750) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" promotor_-10 complement(1384794..1384813) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384810) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" promotor_-35 complement(1384825..1384831) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1384938..1384946 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1384954 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" promotor_-10 1384957..1384975 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385002..1387218 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" gene 1385002..1387218 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" S_feature complement(1386993..1387933) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1387071..1387078 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387093..1387112 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1387095 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" CDS 1387215..1387712 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" gene 1387215..1387712 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" S_feature 1387713..1387952 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1387802..1387927 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" gene 1387802..1387927 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" downshifts 1387920 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" CDS complement(1387961..1389022) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" gene complement(1387961..1389022) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" downshifts complement(1387978) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" CDS complement(1389030..1390223) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" gene complement(1389030..1390223) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" downshifts 1389090 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" downshifts complement(1390310) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" misc_RNA complement(1390316..1390472) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" gene complement(1390316..1390472) /gene="mswC" /locus_tag="BSU_misc_RNA_20" promotor_-10 complement(1390507..1390526) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1390508) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" promotor_-35 complement(1390542..1390549) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1390552..1390555 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1390556..1391335) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" gene complement(1390556..1391335) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" promotor_-10 1390571..1390590 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390580 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1391028..1391035 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1391048..1391067 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1391063 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" S_feature 1391070..1391387 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1391357..1391364 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1391365..1391384) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1391379..1391398 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391379) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" upshifts 1391389 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" promotor_-35 complement(1391400..1391407) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1391430..1392626 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" gene 1391430..1392626 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" promotor_-35 1392608..1392615 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1392630..1392649 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1392649 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" misc_RNA 1392665..1392765 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" gene 1392665..1392765 /gene="mswD" /locus_tag="BSU_misc_RNA_21" downshifts 1392764 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" CDS 1392850..1394067 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" gene 1392850..1394067 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" CDS 1394064..1394771 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" gene 1394064..1394771 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" CDS 1394729..1395358 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" gene 1394729..1395358 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" CDS 1395373..1395909 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" gene 1395373..1395909 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" S_feature complement(1395756..1395949) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1395909 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" CDS complement(1395950..1396270) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" gene complement(1395950..1396270) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" downshifts complement(1396008) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" S_feature complement(1396271..1396360) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1396296..1396302 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396317..1396335 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396327 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" S_feature 1396328..1396412 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1396342..1396361) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1396359) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" promotor_-35 complement(1396376..1396379) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1396386..1396393 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396408..1396427 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1396414..1396472 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1396414 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" downshifts complement(1396470) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" CDS 1396473..1396730 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" gene 1396473..1396730 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" downshifts 1396724 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" CDS 1396816..1397247 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" gene 1396816..1397247 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" CDS complement(1397275..1398795) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" gene complement(1397275..1398795) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" downshifts complement(1397287) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1397996..1398002 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398016..1398027 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398022 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1398803..1398822) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1398824) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" promotor_-35 1398922..1398929 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398944..1398963 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398946 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" CDS 1398988..1399425 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" gene 1398988..1399425 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" downshifts 1399408 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" CDS complement(1399465..1400250) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" gene complement(1399465..1400250) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" downshifts complement(1399484) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" downshifts complement(1399946) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" CDS complement(1400222..1401034) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" gene complement(1400222..1401034) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" promotor_-10 complement(1401065..1401083) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401081) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" promotor_-35 complement(1401097..1401104) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1401172..1401394) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1401204) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" CDS complement(1401417..1403516) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" gene complement(1401417..1403516) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" downshifts complement(1401439) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" S_feature complement(1403517..1403767) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1403727..1403827) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1403767) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" promotor_-35 1403803..1403808 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1403818 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" promotor_-10 1403824..1403842 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1403881..1404924 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" gene 1403881..1404924 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" S_feature 1404925..1405016 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1404993..1404997 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405014..1405033 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405018 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" misc_RNA 1405063..1405107 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" gene 1405063..1405107 /gene="qswA" /locus_tag="BSU_misc_RNA_22" downshifts 1405084 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" S_feature 1405129..1405236 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1405237..1405896 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" gene 1405237..1405896 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" CDS 1405889..1406338 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" gene 1405889..1406338 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" CDS 1406331..1407062 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" gene 1406331..1407062 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" CDS 1407080..1407577 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" gene 1407080..1407577 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" S_feature 1407578..1407854 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1407812 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" downshifts complement(1407822) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" S_feature complement(1407891..1408135) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1407932) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" CDS complement(1408136..1408492) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" gene complement(1408136..1408492) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" misc_feature complement(1408523..1408542) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1408540) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" promotor_-35 1408558 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408577..1408595 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408582 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" CDS 1408661..1409407 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" gene 1408661..1409407 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" downshifts 1409462 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" promotor_-35 1409810..1409818 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409832..1409851 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409836 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" CDS 1409888..1411087 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" gene 1409888..1411087 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" promotor_-35 1409970..1409976 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409991..1410009 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409997 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" promotor_-35 1411056..1411058 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411078..1411096 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1411090 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" CDS 1411103..1411330 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" gene 1411103..1411330 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" misc_feature complement(1411180..1411199) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1411188) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1411331..1411426 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1411427..1412125 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" gene 1411427..1412125 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo S_feature complement(1412078..1412904) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1412106..1412357 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" gene 1412106..1412357 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo misc_feature 1412607..1412622 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1412630..1412841 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1412630 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" downshifts 1412806 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1412893..1412912) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1412915) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" promotor_-35 complement(1412928..1412935) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1412980..1412987 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1413002..1413021 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1413004 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" CDS 1413040..1413330 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" gene 1413040..1413330 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" S_feature complement(1413367..1413450) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1413410) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" CDS complement(1413451..1413636) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" gene complement(1413451..1413636) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" promotor_-10 complement(1413669..1413688) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413680) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" S_feature complement(1413682..1414026) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1413702..1413709) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1413735..1413740 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1413756..1413775 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1413763 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" CDS 1413802..1413996 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" gene 1413802..1413996 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" downshifts 1413972 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(1414017..1414035) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414033) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" promotor_-35 complement(1414052..1414057) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1414295..1414921 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" gene 1414295..1414921 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" downshifts 1414852 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" promotor_-35 1414978..1414983 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1414990 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" promotor_-10 1414999..1415017 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1415039..1416376 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" gene 1415039..1416376 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" CDS 1416427..1416924 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" gene 1416427..1416924 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" promotor_-35 1416773..1416779 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1416788 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1416794..1416812 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1416898 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" promotor_-35 1417019..1417025 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417036..1417055 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417048 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" S_feature 1417052..1417159 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1417160..1419073 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" gene 1417160..1419073 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" promotor_-10 complement(1417309..1417328) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417326) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1417341..1417350) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1417477..1417496) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417502) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1417510..1417516) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1419054 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" downshifts complement(1419130) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1419341..1419360) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1419350) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1419374..1419381) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1419425..1419444 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1419435 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" CDS 1419480..1420571 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" gene 1419480..1420571 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" downshifts 1420220 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" downshifts 1420550 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" S_feature complement(1420584..1420802) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1420595..1420852 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1420789..1420808) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1420802) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" promotor_-35 complement(1420824..1420831) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1420853..1421818 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" gene 1420853..1421818 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" promotor_-35 1421836..1421843 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1421858..1421877 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1421870 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" CDS 1421881..1422747 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" gene 1421881..1422747 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" promotor_-35 1422602..1422606 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422623..1422642 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422631 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" downshifts 1422749 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" misc_RNA 1422794..1422945 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" S_feature 1422794..1422945 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1422794..1422945 /gene="gswA" /locus_tag="BSU_misc_RNA_88" promotor_-35 1422923..1422929 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422943..1422954 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422947 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" CDS 1422976..1425075 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" gene 1422976..1425075 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" promotor_-35 1425093..1425097 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1425113..1425132 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1425124 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" CDS 1425173..1425439 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" gene 1425173..1425439 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" CDS 1425439..1427151 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" gene 1425439..1427151 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" downshifts 1427138 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" promotor_-35 1427191..1427197 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427212..1427223 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427215 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" CDS 1427242..1427481 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" gene 1427242..1427481 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" S_feature complement(1427262..1428601) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1427559..1428587 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" gene 1427559..1428587 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" downshifts 1428557 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" CDS complement(1428602..1429282) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" gene complement(1428602..1429282) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" promotor_-10 complement(1429292..1429311) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1429315) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" promotor_-35 complement(1429326..1429333) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1429367..1429374 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1429388..1429406 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1429394 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" CDS 1429417..1431384 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" gene 1429417..1431384 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" misc_feature complement(1429857..1429872) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1429869) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1431355 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1431428..1431430 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1431446..1431465 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1431456 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" downshifts complement(1431498) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" CDS 1431522..1432388 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" gene 1431522..1432388 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" downshifts 1432368 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" CDS complement(1432427..1433200) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" gene complement(1432427..1433200) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" downshifts complement(1432444) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1433232..1433251) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1433242) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" misc_feature 1433475..1433494 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1433488 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" S_feature 1433490..1433593 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1433537..1435651 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" gene 1433537..1435651 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" promotor_-10 complement(1434830..1434848) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1434842) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1434864..1434869) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1435632 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" promotor_-35 1435724..1435732 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1435744..1435762 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1435756 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" CDS 1435815..1437635 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" gene 1435815..1437635 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" CDS complement(1437646..1438827) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" gene complement(1437646..1438827) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" downshifts complement(1437680) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1438855..1438874) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1438871) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" promotor_-10 complement(1438903..1438921) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1438915) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" S_feature complement(1438917..1438985) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1438936..1438941) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1438979..1438998) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1438985) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" CDS complement(1439029..1439190) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" gene complement(1439029..1439190) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" promotor_-10 complement(1439213..1439232) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439226) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" promotor_-35 complement(1439246..1439253) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439327..1439334 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1439346 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" promotor_-10 1439347..1439365 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1439394..1440305 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" gene 1439394..1440305 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" downshifts complement(1439399) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" promotor_-35 1439848..1439856 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439870..1439887 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439873 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1440290 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" CDS complement(1440349..1440813) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" gene complement(1440349..1440813) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" downshifts complement(1440367) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1440843..1440862) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440853) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" promotor_-35 complement(1440877..1440884) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1440939..1442231) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" gene complement(1440939..1442231) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" downshifts complement(1440961) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1442255..1442274) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1442259) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" promotor_-35 complement(1442290..1442294) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1442307..1442801) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" gene complement(1442307..1442801) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" promotor_-10 complement(1442817..1442836) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442833) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" promotor_-35 complement(1442850..1442859) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1442858..1443718) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" gene complement(1442858..1443718) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" misc_feature complement(1443739..1443758) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1443752) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" promotor_-35 1443789..1443796 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1443812..1443831 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1443825 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" CDS 1443861..1444625 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" gene 1443861..1444625 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" S_feature 1444626..1444774 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1444755..1444773 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1444776..1444925 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1444776 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" downshifts complement(1444823) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" CDS 1444926..1446656 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" gene 1444926..1446656 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" CDS 1446722..1447240 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" gene 1446722..1447240 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" downshifts 1447238 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" promotor_-35 1447283..1447288 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447301..1447320 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447304 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" CDS 1447336..1447884 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" gene 1447336..1447884 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" S_feature 1447885..1448036 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1448037..1449260 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" gene 1448037..1449260 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" promotor_-10 complement(1449223..1449241) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449233) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1449239 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(1449256..1449261) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1449309..1449316 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1449328..1449429 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1449328 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" promotor_-10 1449331..1449350 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1449346..1449429 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" gene 1449346..1449429 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" downshifts 1449386 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" promotor_-35 1449440..1449445 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1449460..1449744 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1449460 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" promotor_-10 1449462..1449480 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1449721..1449727 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1449741..1449752 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1449746..1449833 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1449746 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" misc_feature 1449822..1449841 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1449835 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1449906..1450145 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" gene 1449906..1450145 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" S_feature 1450146..1450254 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1450255..1450773 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" gene 1450255..1450773 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" promotor_-35 1450810..1450817 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1450831..1450850 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1450845 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1450907..1451104 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" gene 1450907..1451104 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" downshifts 1451100 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" S_feature 1451145..1451241 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1451242..1451685 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" gene 1451242..1451685 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" S_feature 1451686..1451793 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1451761..1451766 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451781..1451800 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451795 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" CDS 1451834..1452715 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" gene 1451834..1452715 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" downshifts 1452694 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" promotor_-35 1452750..1452757 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1452772..1452791 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1452777 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1452827..1453303 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" gene 1452827..1453303 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" CDS 1453293..1454186 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" gene 1453293..1454186 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" CDS 1454202..1454657 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" gene 1454202..1454657 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" promotor_-10 complement(1454473..1454492) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1454486) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1454506..1454514) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1454651 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" promotor_-35 1454696..1454703 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1454717..1454736 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1454718 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1454762..1455472 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" gene 1454762..1455472 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" downshifts complement(1454771) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1454881..1454885) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1454881) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1454903) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1455542..1456666 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" gene 1455542..1456666 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" promotor_-35 1456678..1456684 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456698..1456709 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456700 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" promotor_-10 complement(1456704..1456718) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1456728..1456732) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1456728..1456973 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" gene 1456728..1456973 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" upshifts complement(1456729) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1456961 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" S_feature 1457006..1457956 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1457010..1457813) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" gene complement(1457010..1457813) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" downshifts complement(1457022) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(1457864..1457883) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457873) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" promotor_-35 complement(1457897..1457904) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1457929..1457936 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1457951..1457970 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1457958..1458049 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1457958 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" CDS 1458050..1458592 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" gene 1458050..1458592 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" CDS 1458664..1459110 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" gene 1458664..1459110 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" downshifts 1459118 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" promotor_-35 1459503..1459510 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1459523 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" promotor_-10 1459525..1459544 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1459576..1460151 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" gene 1459576..1460151 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" downshifts 1460129 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" CDS complement(1460192..1461157) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" gene complement(1460192..1461157) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" downshifts complement(1460205) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" promotor_-35 1460501..1460502 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1460520..1460539 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1460526..1461250 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1460526 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 complement(1461178..1461196) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461199) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" promotor_-35 complement(1461211..1461216) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1461237..1461243 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1461253 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 1461257..1461276 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1461294..1461893 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" gene 1461294..1461893 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" CDS 1461944..1462963 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" gene 1461944..1462963 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" CDS 1462981..1464273 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" gene 1462981..1464273 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" CDS 1464234..1464755 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" gene 1464234..1464755 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" CDS 1464755..1465228 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" gene 1464755..1465228 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" CDS 1465221..1465454 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" gene 1465221..1465454 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" downshifts 1465433 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" promotor_-35 1465499..1465504 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1465521..1465539 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1465529 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" S_feature 1465541..1465627 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1465617..1465620 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1465629 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1465635..1465654 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1465678..1467435 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" gene 1465678..1467435 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" CDS 1467447..1469261 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" gene 1467447..1469261 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" promotor_-10 complement(1467884..1467903) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1467894) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1467918..1467925) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1469312..1469321 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1469333..1469348 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469337 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" CDS 1469371..1470066 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" gene 1469371..1470066 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" CDS 1470071..1471204 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" gene 1470071..1471204 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" CDS 1471205..1471897 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" gene 1471205..1471897 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" CDS 1471894..1473087 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" gene 1471894..1473087 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" downshifts 1473065 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" promotor_-35 1473136..1473142 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473156..1473167 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473164 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" promotor_-35 1473209..1473216 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1473231..1473250 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1473236..1473327 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1473236 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" promotor_-35 1473291..1473298 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473312..1473331 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473329 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" CDS 1473367..1474122 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" gene 1473367..1474122 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" upshifts complement(1473515) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1473517..1473519) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1473537) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1474119..1475030 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" gene 1474119..1475030 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" CDS 1475045..1476952 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" gene 1475045..1476952 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" downshifts 1476937 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" promotor_-35 1477021..1477028 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1477039..1477058 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1477042 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" CDS 1477097..1477678 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" gene 1477097..1477678 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" downshifts 1477663 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" downshifts 1477707 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" CDS complement(1477712..1477981) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" gene complement(1477712..1477981) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" downshifts complement(1477717) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" S_feature complement(1477982..1478047) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1478028..1478047) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1478047) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" promotor_-35 1478100..1478107 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478118..1478137 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478122 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" CDS 1478162..1479784 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" gene 1478162..1479784 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" downshifts 1479772 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" CDS 1479841..1480752 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" gene 1479841..1480752 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" downshifts 1480757 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" CDS complement(1480786..1482018) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" gene complement(1480786..1482018) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" downshifts complement(1480797) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1482036..1482055) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482060) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" promotor_-35 complement(1482070..1482075) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1482128..1482262) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" gene complement(1482128..1482262) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" downshifts complement(1482139) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1482284..1482302) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482295) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" S_feature complement(1482297..1482362) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1482318..1482323) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1482363..1483370) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" gene complement(1482363..1483370) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" upshifts complement(1483416) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" promotor_-10 complement(1483417..1483425) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1483439..1483447) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1483557..1483566 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1483578 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" promotor_-10 1483579..1483594 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1483581..1483653 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1483654..1483932 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" gene 1483654..1483932 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" downshifts 1483930 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" S_feature complement(1483964..1485593) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1483975..1484079 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1483987) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" promotor_-35 1484061..1484068 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484080..1484099 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484081 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" CDS 1484122..1485408 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" gene 1484122..1485408 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" CDS 1485424..1486257 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" gene 1485424..1486257 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" promotor_-10 complement(1485590..1485608) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1485605) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" promotor_-35 complement(1485624..1485629) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1486320..1486985 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" gene 1486320..1486985 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" downshifts 1486969 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1487076..1487082 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1487097..1487116) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1487097..1487116 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487109 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" upshifts complement(1487111) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1487140..1488873 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" gene 1487140..1488873 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" S_feature complement(1488268..1488872) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1488862 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" CDS complement(1488907..1490574) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" gene complement(1488907..1490574) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" downshifts complement(1488917) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" CDS complement(1490580..1490789) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" gene complement(1490580..1490789) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" promotor_-10 complement(1490826..1490845) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1490848) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" S_feature complement(1490850..1491027) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1490860..1490863) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1491028) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" promotor_-10 complement(1491030..1491041) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1491055..1491061) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1491100..1491107 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491121..1491140 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491137 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" CDS 1491175..1491948 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" gene 1491175..1491948 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" downshifts 1491919 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" CDS complement(1491984..1492538) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" gene complement(1491984..1492538) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" downshifts complement(1491995) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1492560..1492579) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492570) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" promotor_-35 complement(1492594..1492601) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1492623 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" downshifts complement(1492647) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" CDS complement(1492648..1492806) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" gene complement(1492648..1492806) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" CDS complement(1492713..1492856) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" gene complement(1492713..1492856) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" promotor_-35 1492802..1492806 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1492807..1492875) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1492816..1492830 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492843 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1492859..1492878) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492888) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" promotor_-35 complement(1492891..1492900) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492962..1492969 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1492983..1493002 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492987 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" CDS 1493020..1493691 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" gene 1493020..1493691 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" promotor_-35 1493359..1493368 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1493381..1493399 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1493393 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1493638 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" promotor_-35 1493866..1493871 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1493888..1493907 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1493889..1494114 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1493889 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" misc_feature complement(1493893..1493912) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1493909) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1494013..1494021) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1494019) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1494035..1494043) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1494115..1495230 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" gene 1494115..1495230 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" CDS 1495234..1496211 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" gene 1495234..1496211 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" S_feature 1496212..1496325 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1496246..1496265) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1496263) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1496280..1496283) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1496326..1497654 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" gene 1496326..1497654 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" promotor_-35 1496470..1496477 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1496492..1496511 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1496495 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" CDS 1497659..1499071 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" gene 1497659..1499071 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" downshifts 1499068 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" CDS complement(1499116..1499490) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" gene complement(1499116..1499490) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" downshifts complement(1499164) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" misc_feature complement(1499521..1499540) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1499531) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" promotor_-35 1499694..1499699 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1499715..1499733 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1499725 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" S_feature 1499729..1499838 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1499761) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" promotor_-35 1499822..1499829 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1499840 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" promotor_-10 1499844..1499863 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1499859..1500069 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" gene 1499859..1500069 /gene="srrA" /locus_tag="BSU_misc_RNA_70" CDS 1499909..1500028 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" gene 1499909..1500028 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" downshifts complement(1499915) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" downshifts 1500015 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" S_feature 1500060..1501663 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1500068..1501540) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" gene complement(1500068..1501540) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" downshifts complement(1500086) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" S_feature complement(1501541..1501636) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1501619..1501638) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1501636) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" promotor_-35 1501643..1501646 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1501653..1501660) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1501661..1501680 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1501665 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" CDS 1501725..1501991 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" gene 1501725..1501991 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" downshifts 1501973 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" CDS complement(1502024..1502662) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" gene complement(1502024..1502662) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" downshifts complement(1502049) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1502683..1502702) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1502707) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" promotor_-35 complement(1502717..1502721) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1502732..1502738 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1502753..1502771 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1502754 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" promotor_-35 1502792..1502801 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1502814..1502833 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1502818..1502901 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1502818 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" CDS 1502902..1503090 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" gene 1502902..1503090 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" downshifts complement(1502907) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" downshifts 1503083 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" upshifts complement(1503105) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1503113..1503116) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1503160..1503163 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503180..1503199 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503183 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" CDS 1503230..1504027 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" gene 1503230..1504027 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" CDS 1504053..1504481 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" gene 1504053..1504481 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" downshifts 1504438 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" S_feature 1504482..1505435 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1504557) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" CDS complement(1504559..1505473) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" gene complement(1504559..1505473) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" promotor_-10 complement(1505539..1505558) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1505547) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" promotor_-35 complement(1505573..1505580) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1505825..1507390) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" gene complement(1505825..1507390) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" promotor_-10 complement(1507425..1507444) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1507436) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" promotor_-35 complement(1507458..1507465) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1507675..1509615 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" gene 1507675..1509615 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" CDS 1509605..1509874 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" gene 1509605..1509874 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" promotor_-35 1509840..1509844 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1509858..1509877 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1509871 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" CDS 1509874..1510395 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" gene 1509874..1510395 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" CDS 1510392..1510685 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" gene 1510392..1510685 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" CDS complement(1510725..1511336) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" gene complement(1510725..1511336) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" downshifts complement(1510739) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1511368..1511387) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1511377) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" promotor_-35 complement(1511402..1511405) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1511592) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" CDS complement(1511609..1511797) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" gene complement(1511609..1511797) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" downshifts complement(1511663) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1511819..1511838) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1511836) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" promotor_-35 complement(1511851..1511858) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1511864..1511883 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1511871 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" CDS 1511910..1513748 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" gene 1511910..1513748 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" CDS 1513805..1514122 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" gene 1513805..1514122 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" downshifts 1514096 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" downshifts complement(1514171) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" CDS complement(1514178..1514387) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" gene complement(1514178..1514387) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" misc_feature complement(1514401..1514420) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1514416) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" CDS complement(1514470..1515099) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" gene complement(1514470..1515099) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" downshifts complement(1514501) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1515001..1515019) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1515007) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1515031..1515039) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1515134..1515145) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1515139) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" promotor_-35 1515151..1515156 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1515160..1515166) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1515172..1515190 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1515172 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" S_feature 1515173..1515253 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1515254..1516582 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" gene 1515254..1516582 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" S_feature complement(1516438..1516585) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1516481) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" S_feature 1516583..1517173 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1516586..1517071) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" gene complement(1516586..1517071) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" promotor_-10 complement(1517083..1517102) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517111) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" promotor_-35 complement(1517117..1517124) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1517174..1518103 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" gene 1517174..1518103 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" misc_feature 1517688..1517707 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1517697 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" promotor_-35 1518127..1518130 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518145..1518164 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518153 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" CDS 1518201..1518482 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" gene 1518201..1518482 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" downshifts 1518471 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" promotor_-35 1518545..1518548 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1518561..1518687 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1518561 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" promotor_-10 1518566..1518572 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1518688..1519899 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" gene 1518688..1519899 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" promotor_-35 1519909..1519913 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1519928..1519947 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1519947 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" CDS 1519974..1523420 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" gene 1519974..1523420 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" promotor_-10 complement(1522986..1523004) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1523006) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1523020..1523025) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1523400 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" downshifts 1523445 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" downshifts complement(1523477) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" downshifts 1523489 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" CDS complement(1523823..1524743) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" gene complement(1523823..1524743) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" downshifts complement(1523829) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1524783..1524802) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1524798) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" promotor_-35 complement(1524816..1524823) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1524878..1524885 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524899..1524918 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1524900..1525005 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1524900 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" S_feature 1525007..1525097 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1525007 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" promotor_-35 1525013..1525016 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525031..1525047 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1525098..1526015 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" gene 1525098..1526015 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" downshifts 1526044 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" upshifts 1526063 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" misc_feature 1526064..1526069 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1526123..1526128 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1526143..1526161 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1526151..1526254 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1526151 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" CDS 1526255..1527325 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" gene 1526255..1527325 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" CDS 1527358..1529226 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" gene 1527358..1529226 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" CDS 1529226..1529849 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" gene 1529226..1529849 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" CDS 1529852..1530184 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" gene 1529852..1530184 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" CDS 1530211..1531104 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" gene 1530211..1531104 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" downshifts 1531079 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" CDS complement(1531136..1531498) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" gene complement(1531136..1531498) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" downshifts complement(1531155) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" promotor_-35 1531491..1531495 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1531504..1531517 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1531522..1531541) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1531526..1531637 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1531526 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" upshifts complement(1531534) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" promotor_-35 complement(1531556..1531563) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1531638..1532084 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" gene 1531638..1532084 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" promotor_-35 1531670..1531677 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1531689..1531708 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1531694 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" promotor_-35 1532093..1532100 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1532114..1532133 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1532125 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" CDS 1532168..1533208 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" gene 1532168..1533208 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" promotor_-10 complement(1533131..1533149) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1533136) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1533165..1533170) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1533188 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" promotor_-35 1533372..1533381 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1533395..1533414 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1533409 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" CDS 1533440..1533838 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" gene 1533440..1533838 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" downshifts complement(1533444) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" CDS 1533854..1534093 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" gene 1533854..1534093 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" downshifts 1534072 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" promotor_-35 1534160..1534167 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1534178..1534197 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1534183 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" CDS 1534209..1534658 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" gene 1534209..1534658 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" downshifts 1534644 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" CDS 1534713..1534985 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" gene 1534713..1534985 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" S_feature complement(1534790..1535013) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1534988..1535108 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" gene 1534988..1535108 /gene="csfG" /locus_tag="BSU_misc_RNA_23" S_feature complement(1535015..1535138) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1535058) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" S_feature 1535109..1535214 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1535139..1535151) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535146) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" promotor_-35 complement(1535166..1535172) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1535195..1535199 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1535215..1535234 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1535216..1535307 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1535216 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" CDS 1535308..1535862 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" gene 1535308..1535862 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" CDS 1535867..1536352 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" gene 1535867..1536352 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" downshifts 1536319 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" CDS complement(1536363..1537589) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" gene complement(1536363..1537589) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" S_feature 1536364..1537638 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1537590..1537691) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1537613..1537620 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1537632..1537651 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1537640..1537769 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1537640 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" promotor_-10 complement(1537686..1537704) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1537701) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" promotor_-35 complement(1537721..1537726) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1537770..1538552 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" gene 1537770..1538552 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" promotor_-35 1538332..1538338 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1538352..1538363 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1538363 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" CDS 1538554..1539579 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" gene 1538554..1539579 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" downshifts 1539463 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" CDS complement(1539596..1540843) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" gene complement(1539596..1540843) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" downshifts complement(1539623) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" promotor_-35 1540760..1540766 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1540780..1540791 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1540784 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" CDS complement(1540840..1541025) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" gene complement(1540840..1541025) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" promotor_-35 1540858..1540862 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1540878..1540897 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1540887..1541022 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1540887 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" promotor_-10 complement(1540916..1540935) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1540926) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" promotor_-35 complement(1540949..1540956) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1540993..1541000 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1541014..1541033 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1541024 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" CDS 1541053..1541571 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" gene 1541053..1541571 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" CDS 1541593..1541772 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" gene 1541593..1541772 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" downshifts 1541752 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" upshifts complement(1541795) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1541799..1541802) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1541853..1541858 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1541874..1541892 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1541875 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" CDS 1541918..1542499 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" gene 1541918..1542499 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" downshifts 1542500 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" CDS complement(1542556..1543038) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" gene complement(1542556..1543038) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" downshifts complement(1542575) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" downshifts 1543028 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" promotor_-10 complement(1543061..1543080) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1543080) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" promotor_-35 complement(1543094..1543101) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1543138..1543144 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1543156..1543175 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1543158 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" CDS 1543198..1544094 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" gene 1543198..1544094 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" CDS 1544165..1545784 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" gene 1544165..1545784 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" downshifts 1545756 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" promotor_-35 1545818..1545821 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1545836..1545909 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1545836..1545855 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1545836 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" downshifts complement(1545893) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" CDS 1545910..1546341 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" gene 1545910..1546341 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" CDS 1546411..1547346 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" gene 1546411..1547346 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" S_feature complement(1547013..1548465) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1547386..1547739 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" gene 1547386..1547739 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" CDS 1547736..1549886 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" gene 1547736..1549886 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" promotor_-10 complement(1548446..1548464) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1548465) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" promotor_-35 complement(1548479..1548485) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1549869 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1549941..1549946 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1549962..1549980 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1549962 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" CDS 1550003..1551943 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" gene 1550003..1551943 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" promotor_-35 1551739..1551745 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1551760..1551768 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1551766 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" downshifts 1551916 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" S_feature 1551961..1552028 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1551998..1552002 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1552018..1552037 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1552030..1552118 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1552030 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" CDS 1552119..1553603 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" gene 1552119..1553603 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" S_feature 1553604..1553714 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1553715..1554689 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" gene 1553715..1554689 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" CDS 1554690..1556045 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" gene 1554690..1556045 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" promotor_-35 1555869..1555874 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1555890..1555908 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1555900 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" CDS 1556106..1557206 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" gene 1556106..1557206 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" S_feature 1557207..1557328 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1557329..1558420 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" gene 1557329..1558420 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" promotor_-35 1557809..1557818 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1557831..1557846 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1557836 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" promotor_no_box 1557842..1557942 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1557902 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" CDS 1558452..1559363 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" gene 1558452..1559363 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" downshifts 1559381 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" CDS 1559493..1560284 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" gene 1559493..1560284 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" CDS 1560281..1560976 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" gene 1560281..1560976 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" CDS 1560999..1561706 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" gene 1560999..1561706 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" CDS 1561724..1562089 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" gene 1561724..1562089 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" promotor_-35 1561941..1561944 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1561960..1561979 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1561976 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" S_feature 1562090..1562262 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1562263..1563585 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" gene 1562263..1563585 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" upshifts complement(1562470) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1562474..1562478) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1562493..1562497) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1563621..1564769 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" gene 1563621..1564769 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" downshifts 1564743 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" S_feature 1564968..1565071 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1564968 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" misc_feature 1564970..1564989 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1565072..1569373 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" gene 1565072..1569373 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" downshifts 1569370 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" S_feature complement(1569381..1570523) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1569423) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" S_feature 1569501..1569567 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1569503 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" misc_feature 1569504..1569523 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1569521..1569533) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1569533) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1569568..1570497 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" gene 1569568..1570497 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" promotor_-10 complement(1570512..1570531) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1570525) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" promotor_-35 complement(1570546..1570549) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1570560..1571279 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" gene 1570560..1571279 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" S_feature 1571280..1571369 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1571353..1571359 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1571371 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" promotor_-10 1571373..1571384 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1571419..1572201 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" gene 1571419..1572201 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" S_feature 1572202..1572290 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1572255..1572262 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1572275..1572294 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1572292 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1572349..1573143 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" gene 1572349..1573143 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" promotor_-35 1573061..1573064 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1573079..1573098 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1573087 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" misc_RNA 1573156..1573257 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1573156..1573257 /gene="tswE" /locus_tag="BSU_misc_RNA_24" downshifts 1573244 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" CDS 1573345..1574625 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" gene 1573345..1574625 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" misc_feature complement(1574566..1574582) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1574571) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1574646..1574651 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1574667..1574685 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1574671 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" CDS 1574708..1574953 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" gene 1574708..1574953 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" promotor_-35 1574869..1574877 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574888..1574906 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574896 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1574954..1575064 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1575056..1575075 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1575066 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1575116..1575952 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" gene 1575116..1575952 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" CDS 1575959..1576651 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" gene 1575959..1576651 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" CDS 1576648..1577103 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" gene 1576648..1577103 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" CDS 1577110..1577382 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" gene 1577110..1577382 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" downshifts 1577371 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" CDS 1577443..1578216 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" gene 1577443..1578216 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" promotor_-35 1577932..1577939 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577953..1577971 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577976 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1578217..1578309 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1578310..1578804 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" gene 1578310..1578804 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" promotor_-35 1578817..1578824 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578838..1578857 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578845 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" misc_RNA 1578867..1579093 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" gene 1578867..1579093 /gene="iswA" /locus_tag="BSU_misc_RNA_25" downshifts 1579060 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" CDS 1579146..1581911 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" gene 1579146..1581911 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" downshifts 1581902 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1581957) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" promotor_-35 1581992..1581998 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1582013..1582024 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1582013 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" CDS 1582056..1582430 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" gene 1582056..1582430 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" promotor_-35 1582462..1582466 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1582481 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" promotor_-10 1582482..1582501 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1582533..1582997 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" gene 1582533..1582997 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" CDS 1582999..1583910 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" gene 1582999..1583910 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" promotor_-35 1583905..1583912 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1583927..1583946 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1583941 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" misc_RNA 1583950..1584066 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1583950..1584066 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" CDS 1584093..1584638 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" gene 1584093..1584638 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" downshifts complement(1584287) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" downshifts 1584629 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" misc_RNA 1584642..1584759 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1584642..1584759 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" CDS 1584812..1586119 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" gene 1584812..1586119 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" misc_RNA 1586120..1586234 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1586120..1586234 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" CDS 1586265..1587179 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" gene 1586265..1587179 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" CDS 1587163..1588449 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" gene 1587163..1588449 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" CDS 1588446..1589540 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" gene 1588446..1589540 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" CDS 1589525..1592740 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" gene 1589525..1592740 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" CDS 1592737..1593507 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" gene 1592737..1593507 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" CDS 1593507..1594442 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" gene 1593507..1594442 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" CDS 1594411..1595130 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" gene 1594411..1595130 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" CDS 1595109..1595759 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" gene 1595109..1595759 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" downshifts 1595761 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" S_feature 1595806..1595878 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1595858..1595865 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1595879..1595898 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1595880 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" misc_RNA 1595904..1596009 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" gene 1595904..1596009 /gene="mswE" /locus_tag="BSU_misc_RNA_29" S_feature 1596010..1596170 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1596171..1596872 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" gene 1596171..1596872 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" CDS 1596884..1597948 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" gene 1596884..1597948 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" CDS 1597997..1599145 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" gene 1597997..1599145 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" upshifts complement(1598086) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1598098..1598102) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1598120..1598121) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1599158..1599751 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" gene 1599158..1599751 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" S_feature 1599752..1599849 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1599850..1600623 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" gene 1599850..1600623 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" promotor_-35 1600528..1600535 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1600550..1600569 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1600551 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" CDS 1600626..1601411 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" gene 1600626..1601411 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" CDS 1601392..1601880 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" gene 1601392..1601880 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" downshifts 1601860 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" downshifts complement(1601907) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" CDS complement(1601920..1603638) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" gene complement(1601920..1603638) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" promotor_-10 complement(1603660..1603679) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1603674..1603679 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1603674) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" promotor_-35 complement(1603692..1603697) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603695..1603713 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1603699 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" CDS 1603754..1606426 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" gene 1603754..1606426 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" promotor_-10 complement(1605159..1605178) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1605170) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1605193..1605200) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1606432..1606451 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1606435..1606508 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1606435 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1606509..1607384 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" gene 1606509..1607384 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" CDS 1607461..1607730 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" gene 1607461..1607730 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" misc_feature complement(1607541..1607545) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1607546) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1607738..1608352 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" gene 1607738..1608352 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" CDS 1608356..1608559 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" gene 1608356..1608559 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" downshifts 1608548 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" CDS 1608640..1609860 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" gene 1608640..1609860 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" S_feature complement(1609699..1610274) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1609857..1612274 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" gene 1609857..1612274 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" promotor_-10 complement(1610270..1610288) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1610274) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" promotor_-35 complement(1610302..1610308) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1612125..1612129 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1612145..1612164 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1612156 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1612301..1612783 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" gene 1612301..1612783 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" CDS 1612788..1613741 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" gene 1612788..1613741 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" CDS 1613728..1615071 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" gene 1613728..1615071 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" CDS 1615075..1616166 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" gene 1615075..1616166 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" CDS 1616173..1616937 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" gene 1616173..1616937 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" downshifts 1616226 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" CDS 1616931..1618877 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" gene 1616931..1618877 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" promotor_-35 1618786..1618792 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1618806..1618824 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1618822 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1618892..1619788 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" gene 1618892..1619788 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" CDS 1619793..1620446 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " gene 1619793..1620446 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" promotor_-35 1620444..1620453 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1620467..1620486 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1620472 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" CDS 1620519..1621163 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" gene 1620519..1621163 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" promotor_-35 1620924..1620930 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1620941 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" promotor_-10 1620945..1620963 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1621054..1621059 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621075..1621093 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1621088 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" S_feature 1621164..1621234 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1621235..1621315 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" gene 1621235..1621315 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" downshifts 1621330 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" S_feature 1621375..1621747 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1621388..1621576) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" gene complement(1621388..1621576) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" downshifts complement(1621404) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" downshifts complement(1621450) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1621577..1621669) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1621651..1621670) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621669) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" promotor_-35 complement(1621686..1621689) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1621720..1621727 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1621742..1621760 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1621749 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" promotor_-35 1621788..1621791 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1621806..1621825 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1621814 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" CDS 1621853..1622215 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" gene 1621853..1622215 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" downshifts complement(1622066) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" CDS 1622231..1623892 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" gene 1622231..1623892 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" S_feature 1623893..1623982 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1623955..1623962 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1623976..1623995 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1623984 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" CDS 1624031..1624693 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" gene 1624031..1624693 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" CDS 1624719..1625621 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" gene 1624719..1625621 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" CDS 1625599..1627647 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" gene 1625599..1627647 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" promotor_-35 1627683..1627690 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1627705..1627724 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1627711 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1627756..1628322 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" gene 1627756..1628322 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" CDS 1628336..1629337 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " gene 1628336..1629337 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" CDS 1629356..1630309 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" gene 1629356..1630309 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" CDS 1630302..1631042 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" gene 1630302..1631042 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" promotor_-35 1631073..1631077 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1631093..1631112 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1631098 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1631126..1631359 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" gene 1631126..1631359 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" downshifts 1631340 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" promotor_no_box 1631368..1631468 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1631428..1631498 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1631428 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1631499..1632248 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" gene 1631499..1632248 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" downshifts 1632220 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" promotor_-35 1632290..1632296 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1632308..1632327 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632330 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" CDS 1632349..1635909 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" gene 1632349..1635909 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" S_feature complement(1635843..1636913) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1635929..1636918 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" gene 1635929..1636918 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" downshifts 1636905 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" CDS complement(1636955..1637440) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" gene complement(1636955..1637440) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" downshifts complement(1636958) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" promotor_-10 complement(1637462..1637480) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637478) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" promotor_-35 complement(1637494..1637501) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1637543..1637549 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1637564..1637583 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1637566 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1637617..1637949 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" gene 1637617..1637949 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" downshifts complement(1637620) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" CDS 1637963..1639303 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" gene 1637963..1639303 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" S_feature 1639304..1639408 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1639409..1639681 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" gene 1639409..1639681 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" CDS 1639681..1639926 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" gene 1639681..1639926 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" downshifts 1639898 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" S_feature 1639943..1640047 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1640048..1640434 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" gene 1640048..1640434 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" CDS 1640439..1640963 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" gene 1640439..1640963 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" CDS 1640960..1641691 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" gene 1640960..1641691 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" promotor_-35 1641697..1641704 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1641718..1641737 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1641722 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" misc_RNA 1641770..1641811 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" gene 1641770..1641811 /locus_tag="BSU_misc_RNA_30" CDS 1641831..1642178 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" gene 1641831..1642178 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" downshifts 1642180 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" promotor_-35 1642233..1642239 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1642252..1642320 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1642252 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" promotor_-10 1642253..1642272 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1642321..1643169 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" gene 1642321..1643169 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" promotor_-35 1643190..1643197 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1643210..1643228 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1643220 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1643240..1644007 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" gene 1643240..1644007 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" CDS 1644039..1645769 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" gene 1644039..1645769 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" upshifts complement(1645276) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1645277..1645296) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1645311..1645318) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1645766..1646047 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" gene 1645766..1646047 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" downshifts 1645879 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" S_feature 1646048..1646167 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1646139..1646146 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1646160..1646179 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1646169 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1646220..1647377 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" gene 1646220..1647377 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" promotor_no_box complement(1646292..1646392) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1646332) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1647406..1648308 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" gene 1647406..1648308 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" downshifts 1648298 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" CDS 1648369..1649262 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" gene 1648369..1649262 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" promotor_-35 1649268..1649275 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1649290..1649309 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1649297..1649449 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1649297 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1649450..1651525 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" gene 1649450..1651525 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" downshifts 1651495 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" promotor_-35 1651557..1651562 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1651569 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" promotor_-10 1651578..1651596 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651601..1652908 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" gene 1651601..1652908 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" promotor_-35 1652914..1652918 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1652935..1652954 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1652945 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1652976..1653890 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" gene 1652976..1653890 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" promotor_-35 1653015..1653019 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1653032 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" promotor_-10 1653035..1653054 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1653903..1654448 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" gene 1653903..1654448 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" CDS 1654465..1655868 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" gene 1654465..1655868 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" CDS 1655908..1656687 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" gene 1655908..1656687 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" downshifts 1656662 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" downshifts 1656706 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" promotor_-35 1656807..1656814 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1656827..1656845 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1656838..1656991 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1656838 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1656966..1656973 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1656988..1657007 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1656993 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1657067..1657456 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" gene 1657067..1657456 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" CDS 1657456..1657908 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" gene 1657456..1657908 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" CDS 1657919..1658239 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" gene 1657919..1658239 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" downshifts complement(1658234) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" CDS 1658285..1659895 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" gene 1658285..1659895 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" CDS 1659908..1660924 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" gene 1659908..1660924 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" S_feature 1660925..1661042 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1660988..1661088) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1661028) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1661043..1661669 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" gene 1661043..1661669 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" CDS 1661666..1662982 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" gene 1661666..1662982 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" CDS 1662985..1663428 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" gene 1662985..1663428 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" CDS 1663440..1664054 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" gene 1663440..1664054 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" CDS 1664067..1665530 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" gene 1664067..1665530 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" CDS 1665527..1665949 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" gene 1665527..1665949 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" CDS 1665971..1666765 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" gene 1665971..1666765 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" CDS 1666805..1667020 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" gene 1666805..1667020 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" CDS 1667017..1667439 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" gene 1667017..1667439 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" CDS 1667473..1668471 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" gene 1667473..1668471 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" CDS 1668461..1669597 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" gene 1668461..1669597 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" CDS 1669623..1669985 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" gene 1669623..1669985 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" CDS 1670000..1670659 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" gene 1670000..1670659 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" CDS 1670652..1671317 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" gene 1670652..1671317 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" CDS 1671332..1671601 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" gene 1671332..1671601 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" CDS 1671609..1672388 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" gene 1671609..1672388 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" CDS 1672388..1673470 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" gene 1672388..1673470 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" CDS 1673503..1675536 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" gene 1673503..1675536 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" CDS 1675536..1676636 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" gene 1675536..1676636 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" promotor_-10 complement(1676513..1676532) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1676520) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1676546..1676555) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1676627..1677523 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" gene 1676627..1677523 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" CDS 1677525..1678598 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" gene 1677525..1678598 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" CDS 1678604..1680622 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" gene 1678604..1680622 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" CDS 1680644..1681114 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" gene 1680644..1681114 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" CDS 1681133..1681762 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" gene 1681133..1681762 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" CDS 1681759..1682259 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" gene 1681759..1682259 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" CDS 1682282..1683046 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" gene 1682282..1683046 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" promotor_-35 1683056..1683062 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1683075..1683578 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" gene 1683075..1683578 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" promotor_-10 1683077..1683088 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1683091 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1683574..1683580 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1683595..1683614 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1683597..1683721 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1683597 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1683722..1684462 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" gene 1683722..1684462 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" downshifts 1684444 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" S_feature 1684489..1684563 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1684564..1685445 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" gene 1684564..1685445 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" S_feature 1685446..1685590 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1685591..1686313 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" gene 1685591..1686313 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" CDS 1686315..1686872 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" gene 1686315..1686872 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" downshifts complement(1686819) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" promotor_-35 1686861..1686864 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1686879..1686898 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1686897..1687002 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1686897 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1687003..1687785 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" gene 1687003..1687785 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" CDS 1687789..1688598 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" gene 1687789..1688598 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" promotor_-35 1688579..1688586 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1688601..1688620 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1688602 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1688660..1689811 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" gene 1688660..1689811 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" CDS 1689818..1691086 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" gene 1689818..1691086 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" CDS 1691119..1692813 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" gene 1691119..1692813 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" S_feature 1692814..1692921 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1692922..1697235 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" gene 1692922..1697235 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" S_feature 1697236..1697300 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1697246..1697463 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 1697246..1697463 /gene="surG" /locus_tag="BSU_misc_RNA_71" promotor_-35 1697272..1697278 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1697293..1697304 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1697302..1697369 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1697302 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" promotor_-35 1697352..1697358 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1697371..1697564 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1697371 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" promotor_-10 1697372..1697391 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1697565..1698035 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" gene 1697565..1698035 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" downshifts complement(1697886) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" CDS 1698070..1699185 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" gene 1698070..1699185 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" promotor_no_box complement(1698132..1698232) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1698172) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1699199..1699474 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" gene 1699199..1699474 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" CDS 1699476..1699778 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" gene 1699476..1699778 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" CDS 1699798..1701948 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" gene 1699798..1701948 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" promotor_-35 1701843..1701849 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1701858 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" promotor_-10 1701864..1701882 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1701945..1702223 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" gene 1701945..1702223 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo CDS 1702240..1702593 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" gene 1702240..1702593 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" downshifts 1702584 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" CDS 1702675..1703604 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" gene 1702675..1703604 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" promotor_-35 1703389..1703396 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1703410..1703429 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1703419 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" CDS 1703623..1704573 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" gene 1703623..1704573 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" promotor_-35 1704606..1704612 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1704613..1704729 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1704613 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" promotor_-10 1704627..1704646 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1704730..1704999 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" gene 1704730..1704999 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" downshifts 1704982 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" S_feature 1705027..1705112 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1705093..1705096 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705112..1705131 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705114 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" CDS 1705172..1707289 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" gene 1705172..1707289 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" downshifts 1707072 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" downshifts 1707273 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" S_feature 1707318..1707406 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1707407..1708366 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" gene 1707407..1708366 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" promotor_-10 complement(1707475..1707483) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707478) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1707497..1707504) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707970..1707975 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1707991..1708009 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1707996 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" CDS 1708406..1709635 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" gene 1708406..1709635 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" downshifts 1709624 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" promotor_-35 1709664..1709669 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1709679 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" promotor_-10 1709685..1709703 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1709713..1709970 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" gene 1709713..1709970 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" S_feature 1709971..1710025 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1709998 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" promotor_-35 1710067..1710076 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1710086..1710155 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1710086 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" promotor_-10 1710090..1710109 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1710156..1711049 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" gene 1710156..1711049 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" CDS 1711052..1711654 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" gene 1711052..1711654 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" misc_feature 1711708..1711727 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1711708..1711779 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1711708 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" CDS 1711780..1712820 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" gene 1711780..1712820 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" S_feature 1712821..1712911 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1712912..1714126 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" gene 1712912..1714126 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" CDS 1714157..1715029 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" gene 1714157..1715029 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" S_feature complement(1714500..1715684) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1715036 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" promotor_-35 1715129..1715132 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1715146 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" promotor_-10 1715148..1715167 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1715207..1716874 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" gene 1715207..1716874 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" promotor_-10 complement(1715671..1715689) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715688) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" promotor_-35 complement(1715705..1715710) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1716862 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" promotor_-35 1716929..1716935 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1716949..1716960 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1716950 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" CDS 1716990..1717727 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" gene 1716990..1717727 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" CDS 1717724..1717936 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" gene 1717724..1717936 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" misc_feature 1717964..1717983 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1717978 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" CDS 1718067..1720430 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" gene 1718067..1720430 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" S_feature 1720431..1720531 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1720492..1720499 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720514..1720533 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1720532 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" CDS 1720574..1721299 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" gene 1720574..1721299 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" downshifts 1721286 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" promotor_-35 1721355..1721361 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1721374 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" promotor_-10 1721376..1721387 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1721438..1722646 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" gene 1721438..1722646 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" downshifts 1722604 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" promotor_-35 1722715..1722722 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1722735..1722754 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1722757 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" promotor_-35 1722769..1722772 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722788..1722800 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1722802 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" CDS 1722826..1724106 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" gene 1722826..1724106 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" CDS 1724103..1725389 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" gene 1724103..1725389 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" downshifts 1725239 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" S_feature 1725390..1725443 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1725444..1726172 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" gene 1725444..1726172 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" promotor_-35 1726188..1726194 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1726206 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" promotor_-10 1726208..1726219 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726219) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1726230..1726244) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1726253..1726257) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1726253..1726510 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" gene 1726253..1726510 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" downshifts 1726495 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" downshifts complement(1726527) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" promotor_-35 1726568..1726571 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1726586..1726605 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1726586 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" CDS 1726640..1727155 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" gene 1726640..1727155 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo CDS 1727091..1727429 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" gene 1727091..1727429 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo CDS 1727496..1728362 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" gene 1727496..1728362 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" promotor_no_box 1727559..1727659 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1727619 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" downshifts 1728322 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" CDS 1728412..1728993 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" gene 1728412..1728993 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" CDS 1729011..1730261 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" gene 1729011..1730261 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" S_feature 1730262..1730388 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1730368..1730375 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1730390..1730409 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1730390 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" CDS 1730434..1731480 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" gene 1730434..1731480 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" downshifts 1731492 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" S_feature 1731537..1731602 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1731574..1731583 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1731596..1731611 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1731604 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" CDS 1731648..1732823 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " gene 1731648..1732823 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" S_feature 1732824..1732923 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1732897..1732904 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1732918..1732937 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1732925..1733098 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1732925 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" CDS 1733099..1734661 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" gene 1733099..1734661 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" downshifts 1734638 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" CDS 1734730..1735524 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" gene 1734730..1735524 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" promotor_-35 1735279..1735284 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1735300..1735318 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1735320 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" promotor_-35 1735568..1735573 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1735584..1735723 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1735584 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" promotor_-10 1735589..1735607 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1735616) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1735627..1735640) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1735649..1735653) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1735660) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" CDS 1735724..1735984 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" gene 1735724..1735984 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" downshifts 1735936 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" downshifts complement(1735968) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" downshifts 1735980 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" S_feature 1736025..1736199 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1736183..1736190 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1736201 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1736205..1736224 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1736250..1737293 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" gene 1736250..1737293 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" CDS 1737306..1738484 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" gene 1737306..1738484 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" downshifts 1738466 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" promotor_-35 1738564..1738567 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1738576 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1738582..1738601 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1738632..1740161 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" gene 1738632..1740161 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" CDS 1740163..1740594 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" gene 1740163..1740594 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" downshifts 1740577 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1740725..1740730 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740746..1740764 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1740754..1740855 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1740754 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" CDS 1740856..1741401 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" gene 1740856..1741401 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" downshifts 1741395 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" downshifts complement(1741402) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" promotor_-35 1741459..1741462 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1741477..1741496 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1741481 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" CDS 1741534..1744110 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" gene 1741534..1744110 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" CDS 1744126..1746009 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" gene 1744126..1746009 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" S_feature complement(1745912..1746406) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1745924 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" downshifts complement(1745934) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" promotor_-35 1746156..1746163 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746178..1746197 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1746188..1746321 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1746188 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" misc_RNA complement(1746193..1746343) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" gene complement(1746193..1746343) /gene="surX" /locus_tag="BSU_misc_RNA_89" downshifts 1746278 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" CDS complement(1746407..1746862) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" gene complement(1746407..1746862) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" S_feature complement(1746863..1746954) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1746942..1746961) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746954) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" promotor_-35 complement(1746978..1746981) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1747017..1747574) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" gene complement(1747017..1747574) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" promotor_-35 1747658..1747665 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1747678..1747697 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1747680..1747698) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1747683 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" upshifts complement(1747694) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1747695..1748312 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17234808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17234808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of bacillaene synthesis operon" /protein_id="NP_389589.1" /db_xref="EnsemblGenomes-Gn:BSU17080" /db_xref="EnsemblGenomes-Tr:CAB13580" /db_xref="GOA:O34381" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12647" /db_xref="UniProtKB/Swiss-Prot:O34381" /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLG ALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAVRDLLPKEKVLQILLEMVPTNEETIR EMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKDIEAERLYA LVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP*" gene 1747695..1748312 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" promotor_-35 complement(1747713..1747718) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1748300 /Source="Nicolas_upshifts" /id="D926" /incds=0 /nref=121 /ntot=233 /MaxReadThrough="1.91611" /MaxDrop="4.92546" /score="24.8248143" /energy="-17.1" /TU="NA" /idTUdmin="U1367" /TUdmin=0 /isTUend="TRUE" misc_feature 1748419..1748438 /Source="Nicolas_upshift_promotors" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1748432..1748501 /Source="Nicolas_S_feature" /locus_tag="new_1782643_1782712" /HighExp="T3.0H, HiOs, T2.30H, T2.0H, BC, T3.30H, M9-tran, MG 150, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S614" upshifts 1748432 /Source="Nicolas_upshifts" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" CDS 1748502..1749179 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" /EC_number="3.1.2.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in bacillaene synthesis" /protein_id="NP_389590.1" /db_xref="EnsemblGenomes-Gn:BSU17090" /db_xref="EnsemblGenomes-Tr:CAB13581" /db_xref="GOA:O34769" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12648" /db_xref="UniProtKB/Swiss-Prot:O34769" /translation="MNLTYKVHPIKTRYQGWTNYCYIIEDIVSRSAIVVDPSWELSKI TTTLSELEAELKAVALTHSHYDHVNLVDPLTKMFNAQVYMSKKEIDYYQFRCRNLISL DDHQTISIGNTRAQCLLTPGHTAGGMCYLFSESIFTGDTVFTEGCGICEDDGSSAEEM FDSIQRIKSEVSPHVRVYPGHSFGKSPGHSIKDLYQHNIYFQIDKKEYFVKFRTRKNQ KGIFDFK*" gene 1748502..1749179 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" S_feature 1749180..1749447 /Source="Nicolas_S_feature" /locus_tag="new_1783391_1783658" /HighExp="HiOs, T2.0H, M0t90, S2, S1, T4.0H, T-5.40H, Lbstat, M9-tran, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S615" CDS 1749289..1749555 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513956.1" /translation="MKRIIMIWRPICNPGLFSYVLLYLLILYSSMEKSRKTMEQTVGK INLTDNIYRGYHQHEHATIYPVITIIKSYRSETHLLIGRVALRE*" gene 1749289..1749555 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" promotor_-35 1749424..1749431 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1749446..1749465 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1749449..1749551 /Source="Nicolas_S_feature" /locus_tag="new_1783660_1783762" /HighExp="S2, M0t90, M9-stat, HiOs, Lbstat, BC, M40t90, T2.30H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.62175899999999995" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S616" upshifts 1749449 /Source="Nicolas_upshifts" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" CDS 1749552..1750418 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" /EC_number="2.3.1.39" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16707694, 16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl-CoA-acyltransferase involved in bacillaene synthesis" /protein_id="NP_389591.1" /db_xref="EnsemblGenomes-Gn:BSU17100" /db_xref="EnsemblGenomes-Tr:CAB13582" /db_xref="GOA:O34825" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="PDB:5DZ6" /db_xref="SubtiList:BG12649" /db_xref="UniProtKB/Swiss-Prot:O34825" /translation="MITYVFPGQGSQKQGMGSGLFDEFKELTDQADEILGYSIKRLCL ENPYSNLNKTQFTQPALYVVNALSYLKKIRDEEVKPDFVAGHSLGEYNALFAAEAFDF ETGLQLVRKRGELMSLISNGGMAAVMGLNEEQVAKALKEYHLHDVDIANVNAPYQIVI SGKKDEIEKAASLFETMTEVTMVLPLNVSGAFHSRYMNKAKEEFEEFLHAFYFSPPSI PVISNVYAKPYTYEFMKQTLADQINHSVKWTDSISYLMKKGHMEFEEVGPGNVLTGLI HRIKKDAEAMPR*" gene 1749552..1750418 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" S_feature 1750419..1750921 /Source="Nicolas_S_feature" /locus_tag="new_1784630_1785132" /HighExp="S2, Lbstat, M0t90, M40t90, S1, T1.0H, HiOs, T2.30H, M9-tran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S617" CDS 1750922..1751896 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389592.2" /db_xref="EnsemblGenomes-Gn:BSU17110" /db_xref="EnsemblGenomes-Tr:CAB13583" /db_xref="GOA:O34877" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="SubtiList:BG12650" /db_xref="UniProtKB/Swiss-Prot:O34877" /translation="MNEPLVFMFSGQGSQYYHMGKELFKENTVFRQSMLEMDAIAARR IGTSIVEEIYHPGKRVSDPFDSILFSHPAIFMIEYSLYKVLEDRGIYPDYVLGSSLGE FAAAAVSGVSDAEDMLDCILEQAIIIQNSCDKGKMLAILDKPQLLNDHPQLFGNSELI SINYDSHFVISGEEDHIRKIMEDLKEKQILCQLLPVSYAFHSSLIDPAESAYAEFLRS KSFQKPSIPIVSSLTGSCLHVMDENFFWNAVRKPMMFREAIRYLESQHTCKFIDLGPS GTLAAFVKQLIPGDSADRCCSIITPFHQELKNLNTVEYFRTPERKFTR*" gene 1750922..1751896 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" CDS 1751893..1754196 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389593.3" /db_xref="EnsemblGenomes-Gn:BSU17120" /db_xref="EnsemblGenomes-Tr:CAB13584" /db_xref="GOA:O34787" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR014179" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="PDB:5DZ7" /db_xref="SubtiList:BG12651" /db_xref="UniProtKB/Swiss-Prot:O34787" /translation="MITYVFPGQGSQQKGMGQGLFEQYQHLTDQADQILGYSIEKLCT EKSYLDVNHTEYTQPALYVVNALSYLKRVEETGRKPDFAAGHSLGEYNALMAAGAFDF ETGLRLVKKRGELMGRITGGGMAAVIGLSKEQVTAVLEEHRLYDIDVANENTPQQIVI SGPKKEIEKARAVFENTKDVKLFHPLNVSGAFHSRYMNEAKQVFKQYIDSFQFAPLAI PVISNVYAEPYHQDRLKDTLSEQMDNTVKWTDSIRFLMGRGEMEFAEIGPGTVLTGLI HRIKNEAEPLTYIPKKNPAISAHLKEQRNVQAGITAESLGSAEFKQDYHLTYAYLAGG MYRGIASKEMVVKLSRAGMMGFFGTGGLSLKEVEDAIHAIQGELGKGQAYGINLVHNM KHTESEEKMIDLLLRNQVSIVEASAFLSVTPVLVRYRAKGVKRNQNGDVICSNRLIAK ISRPEVAESFLSPAPENMLQKLLGENKITMNEAELLRCIPMADDICVEADSGGHTDGG VAYSLMPAMTSLRDEMMKKYQYRKKIRVGAAGGIGTPEAAMAAFMLGADFILTGSINQ CTVEAATSDKVKDLLQQMNVQDTAYAPAGDMFESGSKVQVLKKGVFFPARANKLYELY QRYGSIRELDAKMLAQLEEKYFKRSIEDIYKDIALHYPAADIEKAEQNPKHKMALIFR WYFRYSSKLAISGSEHSKVDYQIHCGPALGAFNQWVKGSQLENWRNRHVDEIGKKLMT ETAVLLHERMQSMYQPSHETDNIKIKV*" gene 1751893..1754196 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" CDS 1754258..1754506 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl-carrier protein involved in bacillaene synthesis" /protein_id="NP_570904.1" /db_xref="EnsemblGenomes-Gn:BSU17130" /db_xref="EnsemblGenomes-Tr:CAE01454" /db_xref="GOA:Q7PC63" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG14186" /db_xref="UniProtKB/Swiss-Prot:Q7PC63" /translation="MDKQRIFEVLITNICEVLPELDGHRFEPEDQLVELGADSVDRAE IITMVLEDLSLKIPRIELSGVKNIGELAEVLYDKVQSA*" gene 1754258..1754506 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" CDS 1754484..1755731 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase converting malonyl-S-AcpK to acetyl-S-AcpK for bacillaene-related polyketide synthesis" /protein_id="NP_389594.2" /db_xref="EnsemblGenomes-Gn:BSU17140" /db_xref="EnsemblGenomes-Tr:CAB13585" /db_xref="GOA:P40804" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020841" /db_xref="SubtiList:BG10925" /db_xref="UniProtKB/Swiss-Prot:P40804" /translation="MTKCNLPEVVVTGVGVTASIGQGKEDFASSLLSGRHAFDVMKRS GRQKDSRFIGAEIASLSYPDRLSKKMLRKASFSSRAALVTLTEAWEEAELDDADSSRI GLVVGGSNFQQRENFEVYERYQDRSGFISPAYGLSFMDSDLCGICTDQFGITGLAYTV GGASASGQLAVIHAIQQVLSGEVDTCIALGALMDLSYMECEALRALGAMGTDKYADEP ENACRPFDQNRDGFIYGESCGALVIERKETALRRGLKPYAALSGWSIKLDGNRNPDPS LEGEIHVIQKALERARLLPEDIDYINPHGTGSFIGDEIELKALRACRLSHAYINATKS ITGHGLSAAGIVEIISVLLQMKKSALHPSRNLDHPIDDSFHWVNEKSISYRIKNALSL SMGFGGMNTAVCIQNIEKCGGES*" gene 1754484..1755731 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" CDS 1755732..1756994 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-S-AcpK beta-ketothioester bacillaene intermediate transferase" /protein_id="NP_389595.2" /db_xref="EnsemblGenomes-Gn:BSU17150" /db_xref="EnsemblGenomes-Tr:CAB13586" /db_xref="GOA:P40830" /db_xref="InterPro:IPR013528" /db_xref="InterPro:IPR013746" /db_xref="InterPro:IPR016039" /db_xref="PDB:4YXQ" /db_xref="PDB:4YXT" /db_xref="PDB:4YXV" /db_xref="SubtiList:BG10926" /db_xref="UniProtKB/Swiss-Prot:P40830" /translation="MVSAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEKAV ALPYEDPVTFGVNAAKPIIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLN RNCRLFEVKQACYSGTAGFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSED WSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAGDSDLSLM SYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFGGMVKGAHRTMMRKVAKVKTSGI ETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFDTPKRIGCFSYGSGCCSEF YSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKLDFEMIP GIMQSTQEKPRLFLEEISEFHRKYRWIS*" gene 1755732..1756994 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" CDS 1756982..1757761 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase for bacillaene biosynthesis" /protein_id="NP_389596.1" /db_xref="EnsemblGenomes-Gn:BSU17160" /db_xref="EnsemblGenomes-Tr:CAB13587" /db_xref="GOA:P40805" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:3HP0" /db_xref="SubtiList:BG10927" /db_xref="UniProtKB/Swiss-Prot:P40805" /translation="MDLVTYQTIKVRFQASVCYITFHRPEANNTINDTLIEECLQVLN QCETSTVTVVVLEGLPEVFCFGADFQEIYQEMKRGRKQASSQEPLYDLWMKLQTGPYV TISHVRGKVNAGGLGFVSATDIAIADQTASFSLSELLFGLYPACVLPFLIRRIGRQKA HYMTLMTKPISVQEASEWGLIDAFDAESDVLLRKHLLRLRRLNKKGIAHYKQFMSSLD HQVSRAKATALTANQDMFSDPQNQMGIIRYVETGQFPWEDQ*" gene 1756982..1757761 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" CDS 1757801..1758550 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase involved in bacillaene synthesis" /protein_id="NP_389597.2" /db_xref="EnsemblGenomes-Gn:BSU17170" /db_xref="EnsemblGenomes-Tr:CAB13588" /db_xref="GOA:P40802" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:4Q1G" /db_xref="PDB:4Q1H" /db_xref="PDB:4Q1I" /db_xref="PDB:4Q1J" /db_xref="PDB:4Q1K" /db_xref="SubtiList:BG10928" /db_xref="UniProtKB/Swiss-Prot:P40802" /translation="MTHSVVELIEIESAIIQVKMQDRTHKNAFSQELTDDLIQAFEYI RQNPKYKAVILTGYDNYFASGGTQEGLLRIQQGLTKFTDDNLYSLALDCEIPVIAAMQ GHGIGGGFVMGLFADIVILSRESVYTANFMKYGFTPGMGATFIVPKKLGFSLAQEILL NAGSYRGADLEKRGVPFKVLPRAEVLDYAVELAQELAEKPRNSLVTLKDHLVAPLRDQ LPRVIEQELMMHEKTFHHEEVKSRIKGLYGN*" gene 1757801..1758550 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" CDS 1758595..1773726 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 17827323, 26284661, 26268540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389598.3" /db_xref="EnsemblGenomes-Gn:BSU17180" /db_xref="EnsemblGenomes-Tr:CAB13589" /db_xref="GOA:P40806" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:4J1Q" /db_xref="PDB:4J1S" /db_xref="PDB:4NA1" /db_xref="PDB:4NA2" /db_xref="PDB:4NA3" /db_xref="PDB:5KTK" /db_xref="SubtiList:BG10929" /db_xref="UniProtKB/Swiss-Prot:P40806" /translation="MRNNDNIRILTNPSVSHGEPLHISEKQPATIPEVLYRTATELGD TKGIIYLQPDGTEVYQSYRRLWDDGLRIAKGLRQSGLKAKQSVILQLGDNSQLLPAFW GCVLTGVVPAPLAVPPTYAESSSGTQKLKDAWTLLDKPAVITDRGMHQEMLDWAKEQG LEGFRAIIVEDLLSAEADTDWHQSSPEDLALLLLTSGSTGTPKAVMLNHRNIMSMVKG IIQMQGFTREDITFNWMPFDHVGGIGMLHLRDVYLGCQEINVSSETILMEPLKWLDWI DHYRASVTWAPNFAFGLVTDFAEEIKDKKWDLSSMRYMLNGGEAMVAKVGRRILELLE PHGLPADAIRPAWGMSETSSGVIFSHEFTRAGTSDDDHFVEIGSPIPGFSMRIVNDHN ELVEEGEIGRFQVSGLSVTSGYYQRPDLNESVFTEDGWFETGDLGFLRNGRLTITGRT KDAIIINGINYYSHAIESAVEELPEIETSYTAACAVRLGQNSTDQLAIFFVTSAKLND EQMSQLLRNIQSHVSQVIGVTPEYLLPVQKEEIPKTAIGKIQRTQLKTSFENGEFDHL LHKPNRMNDAVQDEGIQQADQVKRVREEIQKHLLTCLTEELHVSHDWVEPNANIQSLG VNSIKMMKLIRSIEKNYHIKLTAREIHQYPTIERLASYLSEHEDLSSLSADKKGTDTY KTEPERSQATFQPLSEVQKGLWTLQKMSPEKSAYHVPLCFKFSSGLHHETFQQAFGLV LNQHPILKHVIQEKDGVPFLKNEPALSIEIKTENISSLKESDIPAFLRKKVKEPYVKE NSPLVRVMSFSRSEQEHFLLVVIHHLIFDGVSSVTFIRSLFDTYQLLLKGQQPEKAVS PAIYHDFAAWEKNMLAGKDGVKHRTYWQKQLSGTLPNLQLPNVSASSVDSQFREDTYT RRLSSGFMNQVRTFAKEHSVNVTTVFLSCYMMLLGRYTGQKEQIVGMPAMVRPEERFD DAIGHFLNMLPIRSELNPADTFSSFISKLQLTILDGLDHAAYPFPKMVRDLNIPRSQA GSPVFQTAFFYQNFLQSGSYQSLLSRYADFFSVDFVEYIHQEGEYELVFELWETEEKM ELNIKYNTGLFDAASISAMFDHFVYVTEQAMLNPSQPLKEYSLLPEAEKQMILKTWNA TGKTYPYITFHELFEQQAKKTPDRAAVSYEGQTLTYRELDEKSTQLAIYLQAHGVGPD RLAGIYVDRSLDMLVGLLAILKAGGAYVPLDPSYPAERLEYMLEDSEVFITLTTSELV NTLSWNGVTTALLDQDWDEIAQTASDRKVLTRTVTPENLAYVIYTSGSTGKPKGVMIP HKALTNFLVSMGETPGLTAEDKMLAVTTYCFDIAALELFLPLIKGAHCYICQTEHTKD VEKLKRDIRAIKPTVMQATPATWKMLFYSGWENEESVKILCGGEALPETLKRYFLDTG SEAWNMFGPTETTIWSAVQRINVECSHATIGRPIANTQIYITDSQLAPVPAGVPGELC IAGDGVAKGYYKKEELTDSRFIDNPFEPGSKLYRTGDMARWLTGGRIEYIGRIDNQVK IRGFRIELGDIESRLSEHPGILECVVVADMDNLAAYYTAKHANASLTARELRHFVKNA LPAYMVPSYFIQLDHMPLTPNGKIDRNSLKNIDLSGEQLKQRQTSPKNIQDTVFTIWQ EVLKTSDIEWDDGFFDVGGDSLLAVTVADRIKHELSCEFSVTDLFEYSTIKNISQYIT EQRMGDASDHIPTDPAAHIEDQSTEMSDLPDYYDDSVAIIGISCEFPGAKNHDEFWEN LRDGKESIAFFNKEELQRFGISKEIAENADYVPAKASIDGKDRFDPSFFQISPKDAEF MDPQLRMLLTHSWKAIEDAGYAARQIPQTSVFMSASNNSYRALLPSDTTESLETPDGY VSWVLAQSGTIPTMISHKLGLRGPSYFVHANCSSSLIGLHSAYKSLLSGESDYALVGG ATLHTESNIGYVHQPGLNFSSDGHIKAFDASADGMIGGEGVAVVLLKKAADAVKDGDH IYALLRGIGVNNDGADKVGFYAPSVKGQADVVQQVMNQTKVQPESICYVEAHGTGTKL GDPIELAALTNVYRQYTNKTQFCGIGSVKTNIGHLDTAAGLAGCIKVVMSLYHQELAP SVNYKEPNPNTDLASSPFYVVDQKKTLSREIKTHRAALSSFGLGGTNTHAIFEQFKRD SDKGKIDGTCIVPISAKNKERLQEYAEDILAYLERRGFENSQLPDFAYTLQVGREAME HRVVFIADHVNELKQRLTDFINGNTAIEGCFQGSKHNAREVSWLTEDEDSAELIRKWM AKGKVNKLAEMWSKGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQIS GNQTGIGSIHPLLHQNTSDFSEQKFSSVFTGDEFFLRDHVVRGKPVLPGVAYLEMAYA AINQAAGSEIGQDVRIRLNHTVWVQPVVVDRHSAQVDISLFPEEDGKITFDIYSTQED GDDPVIHSQGSAELASAAETPVADLTEMSRRCGKGKMSPDQFYEEGRSRGMFHGPAFQ GIKNVNIGNREVLAQLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQELTDQKLIL PFALEELEVIKGCSSSMWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGFSTRV LEGEVHTSKPSTRHERLMLEPVWEKQNEEREDEDLSYTEHIIVLFETERSVTDSIASH MKDARVITLNEAVGHIAERYQCYMQNIFELLQSKVRKLSAGRIIIQAIVPLEKEKQLF AGVSGLFKTAEIEFSKLTAQVIEIEKPEEMIDLHLKLKDDSRRPFDKQIRYEAGYRFV KGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKEIANRTGRSTIVLTGRSVL SEDKENELEALRSIGAEVVYREADVSDQHAVRHLLEEIKERYGTLNGIIHGAGSSKDR FIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCLGNAGQADYAAAN SFMDAFAEYRRSLAASKKRFGSTISFNWPLWEEGGMQVGAEDEKRMLKTTGMVPMPTD SGLKAFYQGIVSDKPQVFVMEGQLQKMKQKLLSAGSKAKRNDQRKADQDQGQTRKLEA ALIQMVGAILKVNTDDIDVNTELSEYGFDSVTFTVFTNKINEKFQLELTPTIFFEYGS VQSLAEYVVAAYQGEWNQDATAKGKDERTNLVHSLSSLEASLSNMVSAILKVNSEDID VNTELSEYGFDSVTFTVFTNKINEEFQLELTPTIFFEYGSLHSLAEYLTVEHGDTLVQ EREKPEGQEELQTKSSEAPKITSRRKRRFTQPIIAKAERNKKQAADFEPVAIVGISGR FPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGNPDTDVNKTDIKWGGFIDGVAE FDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQSLSGTGTGIFIGTGNTGYK DLFHRANLPIEGHAATGHMIPSVGPNRMSYFLNIHGPSEPVETACSSSLVAIHRAVTA MQNGDCEMAIAGGVNTILTEEAHISYSKAGMLSTDGRCKTFSADANGYVRGEGVGMVM LKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADLLVRAYRQADIDPSTV TYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCGIGSVKSNIGHLEL AAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQEWKSVTDRDGNE LPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNKSRLIDRASQL LEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKLQAFVDGKEETDE FFRGQSHRNKETQTIFTADEDMALALDAWIRKRKYAKLADLWVKGVSIQWNTLYGETK PRLISLPSYPFAKDHYWVPAKEHSERDKKELVNAIEDRAACFLTKQWSLSPIGSAVPG TRTVAILCCQETADLAAEVSSYFPNHLLIDVSRIENDQSDIDWKEFDGLVDVIGCGWD DEGRLDWIEWVQRLVEFGHKEGLRLLCVTKGLESFQNTSVRMAGASRAGLYRMLQCEY SHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRYQAFLKAHPETGKAT EQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREEWARFKTS NTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIHCAGLT DMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSAGQ ADYAMANSYMDYFAEAHQKHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSEGL RFLDQIVSKKFGPVVLPAMANQTNWEPELLMKRRKPHEGGLQEAALQSPPARDIEEAD EVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQVLQRINRKL EAALDPSILYEYPTIQRFADWLIGSYSERLSALFGGRISDASAPLENKIEAEASVPGK DRALTPQIQAPAILSPDSHAEGIAVVGLSCRFPGAETLESYWSLLSEGRSSIGPIPAE RWGCKTPYYAGVIDGVSYFDPDFFLLHEEDVRAMDPQALLVLEECLKLLYHAGYTPEE IKGKPVGVYIGGRSQHKPDEDSLDHAKNPIVTVGQNYLAANLSQFFDVRGPSVVVDTA CSSALVGMNMAIQALRGGDIQSAIVGGVSLLSSDASHRLFDRRGILSKHSSFHVFDER ADGVVLGEGVGMVMLKTVKQALEDGDIIYAVVKAASVNNDGRTAGPATPNLEAQKEVM KDALFKSGKKPEDISYLEANGSGSIVTDLLELKAIQSVYRSGHSSPLSLGSIKPNIGH PLCAEGIASFIKVVLMLKERRFVPFLSGEKEMAHFDQQKANITFSRALEKWTDSQPTA AINCFADGGTNAHVIVEAWEKDEKHAIKRSPISPPQLKKRMLSPGEPKLEAETSKMTA ANIWDTYEVEV*" gene 1758595..1773726 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" promotor_-10 complement(1763440..1763459) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763456) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1763473..1763482) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1773710..1787326 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I (bacillaene synthesis)" /protein_id="NP_389600.3" /db_xref="EnsemblGenomes-Gn:BSU17190" /db_xref="EnsemblGenomes-Tr:CAB13602" /db_xref="GOA:Q05470" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR011254" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:5E1V" /db_xref="PDB:5E5N" /db_xref="PDB:5E6K" /db_xref="PDB:5ENY" /db_xref="PDB:5ERF" /db_xref="SubtiList:BG10698" /db_xref="UniProtKB/Swiss-Prot:Q05470" /translation="MRWRSNVKKITKQLTLSLKNPFIYHHVVYGQNVLPGLAYIDIIY QIFREHGFSCSELQLRNLSIYQPLTAEQDAVIVLNIQCAEKKEGQWQITAKGIEKRDG KEASEEKLYMKADMHADSPAIFEETLDLSQIKASAQNVVQLDDVYEQCRRQELVHSEY MKAKGCIYEEEDGVLLELSLGSEAMLHAEGFMFHPTLIDGSGVGANHLLTSLLKGEQR LYLPLFYESFSASALLQTDCMTRIKRSSVRREKELIYVTLEFFNASGEKVAELKNFTS KLVREAELISGKHQDAQETQMTRADTAERDKPADMVSSPVNSYSEAEQFVSQLIAEKI NKPVEQVEKQVGYYQMGLNSSGLLEVVETISDKIGESLSPTLLFEHTTIAELSAFLAE EYAEHFSAAGSLGQNERARVSDSINDHKTVEGSRPAPIEAAGDIAIIGLAGRYPKAAN IHEFWNNLKEGKDCVSEIPESRWDWQRLEGITSPSGKDISKWGGFIDDPDCFDPQFFR ITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNKRQHVGVFAGVMHKDYT LVGAEEASAENVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLALESIR HGECDVALAGGVNLSLHPNKYMTYGVWDMFSTDGHCRTFGKDGDGYVPAEGIGAVLLK PLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPSPVSQADLIETCLEKTGIDPRTISY VEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIGSVKSNIGHAESAAGISGLSKVA LQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQPVIKENGEDVPYPRRAGIS SFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSARNQERLRVYAKRLLDFL HDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAFIEGRKAIQHCWKGRVSR GSEPSRPAESVHKLLEQRKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVR YWVPKAEKKTDRSKQERHILHPLLHQNVSDISGVRFRSAFTGREFFLKDHVIKGEHVL PGAALLEMVRAAVERAAADQFPTGFRLRNIVWVRPFAVTEQQKDIDVRLYPEENGEIT FEICRDPESAEESPIVYGQGSAVLCEAGENPVINIEELKASYNGRTLSPFDCYEAYTE MGIHYGDSHRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRL GGATSLEDRKAMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEG QVCVRLTSYSARVLETDQEGPSEANDTLLFEHIWEERAAERQELIEYDTYKVVVCDVG EQMESLQNHLDCTVLQHDTETIDERFEGYAIQLFEEIKQLMHSKTGGHTFIQVAVPAL DEPQLLSGLTGLLKTAELENPKLTGQLIEIETGMSAGELFEILEENRRYPRDTHIRHW QGKRFVSKWKEVSGEHLSADMPWKDKGVYLITGGAGGLGFIFATEIANQTNDAVVILT GRSPLDERKKKKLKALQKLGIQAIYRQADLADKQTVDALLKETQNVYGDLDGIIHSAG LIKDNFIMKKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQAD YAMANAFMNAFSEYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMV AMETDRGIQALYHGWTSGKPQVLVASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEA EKADMIGEIDEEILREKAENYFKQVLSSVIKLPAGQIDAEAPLEDYGIDSIMIMHVTG QLEKVFGSLSKTLFFEYQDIRSLTRYFIDSRREKLLDILGFETGKPSVERKSEPEKQE IPVIPRKSGFLPLQDKEQKQVREKETEEIAIIGISGRYPQADNIDELWEKLRDGRDCI TEIPADRWDHSLYYDEDKDKPGKTYSKWGGFMKDVDKFDPQFFHISPREAKLMDPQER LFLQCVYETMEDAGYTREHLGRKRDAELGGSVGVYVGVMYEEYQLYGAQEQVRGRSLA LTGNPSSIANRVSYYFDFHGPSIALDTMCSSSLTAIHLACQSLQRGECEAAFAGGVNV SIHPNKYLMLGQNKFMSSKGRCESFGQGGDGYVPGEGVGAVLLKPLSKAVEDGDHIYG IIKGTAINHGGKTNGYSVPNPNAQADVIKKAFVEAKVDPRTVSYIEAHGTGTSLGDPI EITGLSKVFTQETDDKQFCAIGSAKSNIGHCESAAGIAGVTKVLLQMKYRQLAPSLHS NVLNPNIDFLNSPFKVQQELEEWKRPIISVNGKDIELPRIAGVSSFGAGGVNAHILIE EYAPEPVEERLPARKQPAVIVLSAKNEERLQKRAERLLHAIREQTYVEADLHRIAYTL QVGREAMKERLAFVAETMQELEEKLYECISGTENREYVYRGQVKSNKEAIAAFAADED MSKTIEAWLQKGKYAKVLDLWVRGLRIDWSTLYQDQKPRRISLPAYPFARDRYWIDVN AKAEEKRTEEPFAPVQPVIPKPSVDREASGKPANITLQPLMTNQDRLERVPSDTETET ITAEALCDELTAGLAEVLYMDQNEIDPDEAFIDIGMDSITGLEWIKAINKQYGTSLNV TKVYDYPTTRDFAVYLAHELSTQAGEKKQTETYTPIRQKTVVPAAKPANISLQPLEHH QPVQEEAEETIQYAAAEISASRQYTVAIETLHENLRESIADVLYMEPYEVDIDEAFID IGMDSITGLEWIKAVNKQYGTSFTVTRVYDYPTIRDFAEMLKSELGTHLDRKIEHTDS FEAAQQKPAASSHPKPAERPLQPVQHPIKKEHEKKTVPVLQDRPEDAIAIVGMSGRYP GARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMGMLDDIEHFD PLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLGIMSNEYGVM LNRQSRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLARQALINKEID MALVGGVSLYLTPESYMSMCEAGMLSPDGQCKAFDNGANGFVPGEGAGALVLKRLKDA EADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISYVEMHG TGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLCMNH KTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIVI EEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQ TGREAMDYRMAFLADSREMLIKALDDYLAEMPNGSIFAAHVKTKKSEIKLFETDHDAK ALLQTWIEKKRLEKVAELWVKGLQIDWNKLYGEYTPRRISLPAYPFAEEYYWLPTQEG EPETIATAMPQFELMPKRCFLRKQWQPCPIEPAEMTNQTVAILANEETMALAEELSAY FSTYRIFDSQELDRVSAADYEHVAGAIDLIGCGTSHEHSMGWINWLQKLIEQGRASKH HLTVLGVTKGLEAYANEGVLLSGASRAGLYRMLQSEYSHLTSRHADMECEASHEELAR LIAVEYYAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGL GLLCARHFVKTYGVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQV LSLDLTDRVAVEQSLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKV EGLQTLFDLLQDEPLAFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQDKCPI VSIQWPNWKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTN VWKPDKLMQPSLPVEALSHPETKEQTSTRNLFPETVDWLVTLFSDELKIAAEDFETDE PFQEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISAVLQPS VPEKQTPLKPQSAMKQKLVPEQRPQQISHEKTALLAEDIAIIGLSCRFPGAETLEEYW DLIRDGRSAIAPVPPERFGNSSSNYAGLIDEMNRFDHDFFMMSESDVRAMDPQALAVL EESLKLWYHAGYTEKEVKGMRAGVYIGGRSQHKPDPASLSKAKNPIVAGGQNYLAANI SQFFDLKGPSIVLDTACSSALVGLNMAIQALRSGDIEAAVVGGVSLLDADAHRMFHER GLLCDKPSFHIFDKRADGVILGEGVGMVLVKTVNQAVEDGDSIYAVIKAAAINNDGRT AGPSSPNLEAQKDVMLSALEKSGKKTEEISYLEANGSGSAVTDLLELKAIQSIYRSES KAPLGLGSVKPNIGHPLCAEGIASLIKVALMLKHRQLVPFLSGNENMPYFDIEKTDLY FSRSQAEWKETTPAAAINCFADGGTNAHLIIEGWRDSAERPIRRKPLPLPELNRQPVL IKPSAQNVQKKVHSDTGASKDMFWKTFK*" gene 1773710..1787326 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" CDS 1787342..1800130 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15480790, 16707694, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15480790, 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389601.3" /db_xref="EnsemblGenomes-Gn:BSU17200" /db_xref="EnsemblGenomes-Tr:CAB13603" /db_xref="GOA:P40872" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10931" /db_xref="UniProtKB/Swiss-Prot:P40872" /translation="MITEQLHISLNNPIMSNHKVYGQALLPGLAYIDLIYQVFQEHGY AYQELELKNLTIFYPLIADESYDIALTIHVSERKEGTWSIIIDGQKQHGESLSDKRQY VTADMHRKEQTAFAESIDLNQWKSTADRILNLDEIYEQCRSQELVHTGMMKAEGQIYE AKEGAVIDLAVGQEALRHSDAFLFHPTLIDGSGIGSSCLISDQTMYLPLYYESFSASE RLQKGCTARILSSSVRQKKELTYMTIEYFNSAGQKVAELKQFAGKSVRNMSAFHSAKE IQEERAAVSQNISRDYPAFEMYLRQLLAKQLERPAEQMDIHAGYYELGLDSSSLLTVV QEIGDKVGADLAPTLLFEFTTIAELAAHLADHYSIGEADDAVRQSPSPIDGVTSSPEI GEDIAIIGMAGRYPKAKNIQEFWEQLKAGTDCITEIPNSRWEWKESDGLDSPAGKPLS KWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWEAIEDAGYTPETIASPQGE NKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNYAQIANRVSYYCNFHGPSMAVD TVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYCHTFG KGGDGYVSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQAD VIEACLEKTGIDPRTISYVEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKS NIGHAEAAAGISGLTKTVLQLHHKTLVPSLHSEELNPYLKLDQTPFFVQHETKEWEQP SFTENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSETILTKNEEIVIPLSAR NKDRLQAYALKLLDFLSEDVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKLRAFA NGEEEIEGCWTGRAKENQEAAGLASVNALNNNLIRDSEMMEMAKAWVQGKRVTWDDLY GDRKPLKISVPTYPFARERYWISVPEMKTSTVNHILHPLVHRNTSDFTEQRFSSVFTG TEFFLSDHVVQGQKILPGVAYLEMAREAAEKAAGDLDGEQRVVSLKDIVWVRPITIES EPKEIHIGLFPEDNGDISFDIYSSSEHKEEALTIHCQGRAVISDEAETSILNLSSIQT ECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVGKDQLLAKISLPAFLKNDKQHFA LHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQEVDIFSPCPEKIWSYIRYSSD SKAENKVRKYDIDLCDENGRVCVRMKGASMRALDGEQHSKPQLLTDSQLTGHTVMIPV WEPVSLEAEDNASFAGKRAVLCGAAEADRTFIKHHYPQISFVDIRPADDIEAIADKLQ AYGSIDHVLWIAPSHRGSIGSDGQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQ PVTQHEAVQPAHASIHGLAGTMAKEYPHWKIRLLDLEKGCTWPVNHMFALPADRLGHA WAYRNQQWHQQQLIPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWSEYMIRRYQAQIV WIGRSQLNAAIQSKIDRLSALGPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHS AMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQ SHYASGCTFADAFAHQLSQSWACPVKVMNWGYWGNSEAAEDEHYVQLMNQIGLGLIEP AEAMKALEALLSGPVSQTAFIHTTKPVAVEGVNQNEFITLYPEQPSADAESLMERLPT TGRFQRVTHEELDDLLYRLLLGQLQTAELFDGYTLSVERLQQYKTREFYGKWIRQSSE FLLQHGYLKKVGDSLVRKDQAEDIELLWLEWNAKKEKWLKDSETKAMVVLAEAMLQAL PDILTGKVPATDIMFPHSSMELVEGIYKHNQVADYFNKVLADTLLAYLDERLKHDPEA SIRIMEIGAGTGGTSAGIFEKLKPYQKHINEYCYTDLSKAFLLHAEKEYGAENPYLTY QLFDVEKPIDQQEFEAGGYDVVIAANVLHATKNIRQTLRHTKAVMKNNGMLLLNEMAG NSLFPHITFGLLEGWWLYEDPAVRIPGCPGLHPDSWKAALESEGFESVFFPAEAAHDL SHQIVAASSNGLVRRMMKNVILPEKVVSQASNQEPAYIHTIDSEEAGQSKHALLREKS TEYMKKLIGETLKIPAGKIESSEPLEKYGIDSIVVVQLTNTLRKEFDHVSSTLFFEYQ TIDALVEHFIKTKTEALMKLTGLDRQVQQHTPAESRTQSSQKPDQAAKRTRRFRKLGF SGEKETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDWKAY YDKEKGKEGSIYTKWGGFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYASIEDA GYTPDSLCSSRKIGVFAGVMNKNYPTGYGYWSIANRISYLLNFQGPSLAVDTACSSSL TAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNMLSASDTCKSFGDDADGFV DGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHAQAQVIKEAIE RADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSKSNIGHCES AAGIAGLTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPVIGGQEV PRRAGLSSFGAGGSNAHIILEEYIPRTGAQTPKDHPPALIVLSAKNMERLQEKAEQLL TAIKQKRYCETDLIRIAYTLQTGREAMEERLAFIAESLEDLERKLNDFIENKADSLYL DRIDDNKKALAVLSADEDTEKIIEAWMSKGKYTKLLDLWVKGLSFDWGMLYGTQTPVR ISLPAYPFAKERYWAPGAAKAPVSIEQDHDQQTEEPFKVMTFQEVWKEEPATLTSKRI KTLICFLTEREKQNAFASALKNVDQDTKVIFISQGEVYSKQSEYSYQIVRQEPVTFEK AFQSIKEELGEPDAILYMWPMEDKRCIKDHSCIVYLLQGMSAAKLHPSRLLLAGCFED SLDRSYLESWIGFERSLGLVLPHTKVTGIFQPAEQGSMDDWTRKVWAELQASTEQTVL YQNLKRYVNHIEQTTIQPDNSKLKSGGTYLITGGVGGLGYLFAKHLAKNYAANLILTG RSPFNDEKQKQIKELKDLGGEAMYAEADVSDPIAMGDCVKRGKDRFGAINGVIHAAGI ESDSAIFDKKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCCDY AIGNRFQMAYAQYRNELHNGKTFVINWPVWKDGGMKIGDEETTDMYLKSSGQRFLEAE EGIRMFEHILAQQDAQHLVIAGQPSRVSRFLGMTEPAIPEPATQAPLAQENKDEVKTL SIEKRLEHDLKEHIHTLLKISKDKLNLNKNWADFGFDSIYLAKFSNVLSKHFNIEVTP ALFFGYSTLQELISFFLTDHKELIEAFYRDDASEAQKPPEAYAVIPVALEPEASKKSI RQVHDEPIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERRDWGRANRDPEKAV PRWGAFLKDIDRFDPLFFQISPKEAESMDPRQRIFLEEAWHTFEDAGYMGDRIKGKSC GVYVGVEEGEYAHLTGDTDYINGTQNATLSARIAYALDLKGPNMALTAACSSGLVAIH QACSALRQGDCEMALAGGVSLNISHMSFEALTRAEMLSPNGQCKVFDQDANGLVPGEA VAAVLLKPLSKAIEDKDHIYGCIKASGVNYDGKTNGITAPNPFSQAELIENIYEKNEI NPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQKQFCMISSIKPLIGHTFAASGT VALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLCKENRSWIKKNQKPRMGTIST TGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQNDDRLQDAACRMIAYLEQNH NLSLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKEYVEAMKNGGVSGQQRSLYTG YTEGILEEQDEAVLQALAKERNLENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFA RERYWISSGTQQSEAVKQHSQDMKTEIDEPNGKTHIQKIIVQFLARELGISEDRINFK RNFLDYGMDSILGRKLMRHIEKTTQLKMAGREILECQTVQALSDHLALKAEKQNHSAA AHHIKGTYTDEQIIGLMQEVALGKLDFKSVQNIIEGSKSYES*" gene 1787342..1800130 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" CDS 1800198..1816664 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16460000, 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389602.3" /db_xref="EnsemblGenomes-Gn:BSU17210" /db_xref="EnsemblGenomes-Tr:CAB13604" /db_xref="GOA:O31782" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG12652" /db_xref="UniProtKB/Swiss-Prot:O31782" /translation="MKRQLKSPLSEGQKGLWMLQKMSPGMSAYNIPLCFRFSKPIHAE TFKKALLFVQRQYPVLASVIQEENGIPFQSVQLSKDLYFVEEDISAMKSADIMPFLKE KAKEPFQLEAGPLWRTHLFHRLEECIVLITIHHIIFDGVSMLTLISALFEAYQQLLNG IEPLQQPSTADYYDFVDWENRMLTGREGEEHLAYWKEQLSGSLPVLDLPADRPRSSAR KFKGQAYKSLLPHHLRNQIKSFARTNHVNESVVFLSIYKVLLHHYTKQKDIIVGVPTM GRQEDRFETLIGYFINMMAVRSKNIGSQPLTAFIRELQLTVAVGLDHAAFPFPALVRE LNVDRSAADSPVFQTAFLYQNFFQATGLQKVLEPYQTLGIEYIEDIRQEGEFELALEI YEQENETVLHLLYNPDLYELSSIESMMENYMKLAQHMMEDPSLPLEAYSLQLNQEQTS LLEQWNATGTNIANDKCIHEVFEEKAKQTPDAVAVMFEDRSLTYKEVDEKSTSVAVYL QHQGVRPEQPVGICAERSFDMIIGILGILKAGGAYVPLDPSFPQERLKYMLKDSQASI VLTQPNVHDRISGLTGSHVKAINIELACRNGYTDQQSSGLKREVKPEHLAYIIYTSGS TGEPKGVMVEHRSIMNTLNFLESHYPVTAEDAYLLKTNYVFDVSISELFGWFIGDGRL VILPPNGEKSPQLCMDYIETYKVTHINFVPAMLHVFLEMAKDNKRFTEDGPLKYMMVA GEAFPKVLVKKAVSLFTNCRVENIYGPTEASIYAAYFGCGKGDIASHHTPIGKPVSNT KIYIVDQHLKPVPIGKPGELCIAGAGLARGYFKKPGLTAEKFIDNPFESGTKLYKSGD SARWLPDGNIEYLGRIDSQVKIRGFRVELGAIETKLGEFPGILDQAVVVKQLEGHQQL AAYYTEESGHASANPKDLRLHLKSSLPEYMIPSHFIRLDELPLSPSGKVNRKELEKRE IVFNRRKPNHLQLTEIEDQVLRIWEETLKVSGFGPEDGFFDAGGDSLLAVAVAERIKK EFDCEFHVTELFEYSTIRAISEYILEMKNSDLAGTQNEDDHDDKKDGKYPKQKIPPYF DDSVAIVGISCQFPGAKNHHDFWNHIKEGKESIRFFSEEELRANGVPEELIQHPDYVP VQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDAGYVAKEIPATSVYM SASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYFVHSNCS SSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFDASAD GMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEVIQ HVLDTTKIHPETVSYIEAHGTGTKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIG HLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPDIKFESSPFYVVRERKSLEKHAGV HRAALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKNSERLQVYAKEML SYISQDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAFVTGKPLAEGC IQGEKTRMTSAEQLLGNAEADDMASSRISKEELRKLAEMWANGFHVEWRRLYPNIKPR RISLPTYPFAEERYWPESSTGAITTIEPSRLHPLVHHNTSVLSEQRFSSIFTGQEYFI AEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKNVVWVRPVVAGSEPVQV NIGLYDEDGGHIAYRMYGDPESADAEPVVYNQGKAELIQLKREKALDLSKIKKQCDQS KMDAASFYEGMIGADYGPGYKSVEAVYKGDGQLLAKLSLPESVAHTLGDYVLHPSVMD GALQAAEYLQNVVRAELSDTEDFKAALPFALEELEVFRQCVSDMWVYVQFNSKNKPGD LIQKVDIHLCDEHGMICVRLKGFSTRVMEADIQTEPSKINAETLLLQPVWQEQKAANS LAAKKYAEHLVFLCEYDHETRKQIEAAIEDVHVYSLEARPSSVDGRFHSYTEQVFKKV QEIIRTKPKDGILVQIVTSAEGEQQLFSGLTGLLKTACQENAKLTGQMIEVSSEESGE SIAGKLLENQMSSDSYVKYQNGTRYIADWREIKQAKGDGSKPWKDNGVYLISGGAGGL GHIFAKEIAEQTKNATVILAGRSPLSESKSKKLKELHSKGADITYRQTDVTNKIEVYQ LIDDIQKRYGRLNGILHSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPL DFFILFSSLSGSLGSIGQSDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRD GGMQVDQETEKRLVQLAGIVPMRAEKGIQALYQALHSEANQVMVIEGDVQKIKQNMLA KNASAPMEKKEAEHMTEQINSIDADSLLDKVKAMLKREIAKLLKVKLETIDDHAEMTV YGFDSISMTEFTNHINRAYQLELTPTVFFDHPTIHAFGKHLSEEYQSVFAKTFAVRAV SAQLQPAAKQEQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPMAKDVEA YWNILKEGKDCMTEIPKDRWDWREYEGDPAKEVNKTNVKWGGFIDGIADFDPLFFGIS PREAEQMEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSA IEGSAAANTSPSVGPNRVSYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMAL AGGVNTIILPEVYISFDKAGALSKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEA GDHIYGVIKGSAINHGGRAASLTTPNPKAQADVIQSAYQKAGIDPKTVTYIEAHGTGT ELGDPVEINGLKSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIKILLQ LKHKTLVKSLHCENVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIG GVNAHVIIEEYIPEASDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYS DVNLARIAYTLQAGRDAMEERLGIISGSIEDLQKKLKDFAAEKSGVEDVFKGRIDKGT LQMLTEDEEIQEAVEKWMERGKYAKLLELWVKGLDVDWTKLYGENLPKRISLPTYPFA KDRYWISDHIEKSGSIDANQAASRLGGAVLHPLMHQNTSNLSEQRFSSIYTGEEFFLA DHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVVEDQPQQVHI RLLPGENGEISYEIYGHSDVTGEQSIVYSQGSAVLNPAENLPAVDLQSLREQCQESHF SVNEVYDTYRMIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYKMHPGLMD SALQASSILTGAGDNQLTLPFAVQELEVFGACSSEMWVYARYSQGSKATDKVQKRDMD ILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLATLMFEEKWVPKDFKKESPEPHYER HIVMLCDMNGLSKDRIESRMTGAECIVLESFREGLAERFQDYAEQALETVQGLLKSRP QGNVLIQLLTSAQRKQYSFSGLSALLKTAGLENKKLIGQTIEIDSHENVESVIEKLKE NKRHTEDQHIKYEKGKRYINDLDEMQIDDREISMPWRDKGVYLITGGAGGLGFIFAKE IARQAEQPVLILTGRSALNADQQAELNELQQLGARAEYRQVDVTQTEAASELITSITS DYEDLNGVIHSAGLIKDNYLMSKTNEELTQVLAPKVKGLVNVDEATEHLALDFFILFS SISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKEGGMRANK EIENMTLKNTGVTPMRTETGIQALYKGLAFGKDQVIVMEGFKDMMREKLTQKPSSDDV PMKTVQVRVTSEARMDQGNMFDHIQEVLKQTISQLLKIKPEEIDPDMEFNQYGFDSIT LTEFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNAFTAQTPAKAEVLMQPVE QNIKNMTFSTENRFVKPSVTPMQKEADHKPEPIAIVGMSGVFPKAKDVEEYWKNLSSG ADCITEVPKDRWDWQEYYGDPLKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQME PQQRLLMTYAWKAVEEAGHSARSLAGTKTGIFIGTGNTGYSSLLSNVDIEGSAAANMS PSAGPNRVSYFLNIHGPSEPIDTACSSSLVAIHHAVCAIENGNCEMAIAGGVNTVVTP QGHIAYDKAGALSKEGRCKTFSDKADGFAVSEGAGILFLKKLTAAERDGDHIYGVIKG SAVNHGGRANSLTTPNPKAQADVVKTAYEKAGIDPRTVTYIEAHGTGTELGDPVEING LKAAFKELYEKTGDPAVHGSHCGLGSAKTNIGHLSLAAGVAGVIKVLLQLKHKTLVKS LYSETVNPYIRLDDSPFYIVQESREWQALRDEAGRELPRRAGISSFGIGGVNAHVVIE EYIPKETTHPATAPAVTAQHPGIFILSAKDEDRLKDQARQLADFISKRSITARDLTDI AYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEGGTNAKYMYRGRAEKGIAQTLRSD DEVQKTLNNSWEPHIYERLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWIT DTKEEAAAHQTALKTVESAALHPLIHVNTSDLSEQRFSSAFTGAEFFFADHKVKGKPV MPGVAYLEMVHAAVTRAVRRTEDQQSVIHIKNVVWVQPIVADGQPVQVDISLNPQQDG EIAFNVYTEAAHNDRKIHCQGSASIRGAGDIPVQDISALQDQCSLSTLSHDQCYELFK AIGIDYGPGFQGIDRLYIGRNQALAELSLPAGVTHTLNEFVLHPSMADSALQASIGLK LNSGDEQLSLPFALQELEIFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRVCVRI KGITSRLLEEGIQPPDGPTSLGNSKATLNGALLMAPIWDRVQLEKRSISPADERVVIL GGDDNSRKAVQREFPFAKELYIEPNASIHRITGQLEALGSFDHIVWMSPSRVTECEVG DEMIEAQDQGVIQMYRLIKAMLSLGYGQKEISWTIVTVNTQYVDQHDIVDPVDAGVHG LIGSMSKEYPNWQTKLIDVKKYEDLPLSQLLSLPADQEGNTWAYRNKIWHKLRLIPVH NNQPVHTKYKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIGRRKKDAAIQSKLDR FARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIVLQDRSLMNMSEECF RNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAAGCSFKDAFAQRL SQVWPCTVAVMNWSYWGSIGVVSSPDYQKRMAQAGIGSIEAPEAMEALELLLGGPLKQ LVMMKMANETNDEAEQTEETIEVYPETHGSAIQKLRSYHPGDNTKIQQLL*" gene 1800198..1816664 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" CDS 1816679..1824310 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10960106, 15480790, 16707694, 17234808, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389604.2" /db_xref="EnsemblGenomes-Gn:BSU17220" /db_xref="EnsemblGenomes-Tr:CAB13606" /db_xref="GOA:O31784" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036736" /db_xref="PDB:4U3V" /db_xref="SubtiList:BG12654" /db_xref="UniProtKB/Swiss-Prot:O31784" /translation="MLNTEDILCKMLFAQLQSIGFFTESKSQPVLENFYGRWFEESQS ILERHQFLKRTENGHVPTRSIGTMSELWKEWNEQKFDLLQDNNMKAMVTLVETALKAL PEILTGKASATDILFPNSSMDLVEGVYKNNQVADYFNDVLADTLTAYLQERLKQEPEA KIRILEIGAGTGGTSAAVFQKLKAWQTHIKEYCYTDLSKAFLMHAENKYGPDNPYLTY KRFNVEEPASEQHIDAGGYDAVIAANVLHATKNIRQTLRNAKAVLKKNGLLLLNEISN HNIYSHLTFGLLEGWWLYEDPDLRIPGCPGLYPDTWKMVLESEGFRYVSFMAEQSHQL GQQIIAAESNGVVRQKKRTEAEEDPSHIQMNAEIDHSQESDSLIEQTAQFVKHTLAKS IKLSPERIHEDTTFEKYGIDSILQVNFIRELEKVTGELPKTILFEHNNTKELVEYLVK GHENKLRTALLKEKTKPAKNEAPLQTERTDPNKPFTFHTRRFVTEQEVTETQLANTEP LKIEKTSNLQGTHFNDSSTEDIAIIGVSGRYPMSNSLEELWGHLIAGDNCITEAPESR WRTSLLKTLSKDPKKPANKKRYGGFLQDIEAFDHQLFEVEQNRVMEMTPELRLCLETV WETFEDGGYTRTRLDKLRDDDGVGVFIGNMYNQYFWNIPSLEQAVLSSNGGDWHIANR VSHFFNLTGPSIAVSSACSSSLNAIHLACESLKLKNCSMAIAGGVNLTLDLSKYDSLE RANLLGSGNQSKSFGTGNGLIPGEGVGAVLLKPLSKAMEDQDHIYAVIKSSFANHSGG RQMYTAPDPKQQAKLIVKSIQQSGIDPETIGYIESAANGSALGDPIEVIALTNAFQQY TNKKQFCAIGSVKSNLGHLEAASGISQLTKVLLQMKKGTLVPTINAMPVNPNIKLEHT AFYLQEQTEPWHRLNDPETGKQLPRRSMINSFGAGGAYANLIIEEYMETAPEKEHIAP RQQEFTAVFSAKTKWSLLSYLENMQLFLEKEASLDIEPVVQALHRRNHNLEHRTAFTV ASTQELIEKLKVFRTSRESSLQQGIYTSFDLQPCAESASRDREINAAEQWAQGALIAF KEADIGNRTGWVHLPHYAFDHNTSFHFDVSSINEKSSDVEDNINQPVIQDQFTYDEPY VQGHVFNNERVLVGATYGSLAIEAFFNLFPEENSGRISKLSYISPIVIKQGETIELQA KPLQKDQVIELQIMYREPSSGLWKPAAIGQCGIGSFEPKKVNIENVKHSLTKLHHIDQ MYKTGNGPEWGELFKTITHLYRDHKSILAKIRLPQSGLANGHHYTVSPLMTNSAYLAI LSFLEQFDMTGGFLPFGINDIQFTKQTIKGDCWLLITLVKNTGDMLLFDVDVINESSE TVLHYSGYSLKQLRISNQRGNQNKAIKASNLKARIRSYVTDKLAVNMADPSKLSIAKA HIMDFGIDSSQLVALTREMEAETKIELNPTLFFEYPTIQELIDFFADKHEASFAQLFG EAHQQEERPAQIENQMKQIPAYETNTDKTIEHAADGIAIIGMSGQFPKANSVTEFWDN LVQGKNCVSEVPKERWDWRKYAAADKEGQSSLQWGGFIEGIGEFDPLFFGISPKEAAN MDPQEFLLLIHAWKAMEDAGLTGQVLSSRPTGVFVAAGNTDTAVVPSLIPNRISYALD VKGPSEYYEAACSSALVALHRAIQSIRNGECEQAIVGAVNLLLSPKGFIGFDSMGYLS EKGQAKSFQADANGFVRSEGAGVLIIKPLQKAIEDSDHIYSVIKGSGVSHGGRGMSLH APNPAGMKDAMLKAYQGAQIDPKTVTYIEAHGIASPLADAIEIEALKSGCSQLELELP QEVREEAPCYISSLKPSIGHGELVSGMAALMKVSMAMKHQTIPGISGFSSLNDQVSLK GTRFRVTAENQQWRDLSDDAGKKIPRRASINSYSFGGVNAHVILEEYIPLPKPPVSMS ENGAHIVVLSAKNQDRLKAIAQQQLDYVNKQQELSLQDYAYTLQTGREEMEDRLALVV RSKEELVIGLQACLAEKGDKLKSSVPVFSGNAENGSSDLEALLDGPLREMVIETLLSE NNLEKIAFCWTKGVQIPWEKLYQGKGARRIPLPTYPFEKRSCWNGFQAVENTPSVSQD ERINNSSDHHILANVLGMAPDELQFHKPLQQYGFDSISCIQLLQQLQSKVDPLIVLTE LQACHTVQDMMDLIAKKQEDTSLQNDQARTFPELIPLNDGKRGRPVFWFHGGVGGVEI YQQFAQKSQRPFYGIQARGFMTDSAPLHGIEQMASYYIEIIRSIQPEGPYDVGGYSLG GMIAYEVTRQLQSQGLAVKSMVMIDSPYRSETKENEASMKTSMLQTINTMLASIAKRE KFTDVLISREEVDISLEDEEFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLE SYTVKPLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHF HLVDVDSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETD ELVKR*" gene 1816679..1824310 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" downshifts 1824299 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" CDS complement(1824355..1825572) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" gene complement(1824355..1825572) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" downshifts complement(1824374) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(1825587..1825687) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1825627) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" promotor_-10 complement(1825659..1825678) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1825671) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" S_feature complement(1825673..1825753) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1825693..1825700) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1825797) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" CDS complement(1825803..1826159) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" gene complement(1825803..1826159) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" misc_feature complement(1826219..1826232) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1826224) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" CDS complement(1826238..1827062) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" gene complement(1826238..1827062) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" promotor_-10 complement(1827084..1827103) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827100) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" promotor_-35 complement(1827115..1827121) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1827173..1828501) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" gene complement(1827173..1828501) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" downshifts complement(1827180) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" promotor_-10 complement(1828524..1828543) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828543) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" promotor_-35 complement(1828557..1828565) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1828658..1828665 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1828673..1828692) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1828681..1828700 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828684) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" upshifts 1828687 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" promotor_-35 complement(1828705..1828712) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1828726..1828803 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" gene 1828726..1828803 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo downshifts complement(1828728) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" CDS 1828781..1828957 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" gene 1828781..1828957 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo downshifts 1828938 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" S_feature 1828983..1829171 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1829166..1829185 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1829173 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" CDS 1829237..1829944 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" gene 1829237..1829944 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" promotor_-35 1829955..1829961 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829975..1829994 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829979 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" CDS 1830014..1830466 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" gene 1830014..1830466 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" downshifts 1830454 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" CDS complement(1830480..1830833) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" gene complement(1830480..1830833) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" downshifts complement(1830521) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" CDS complement(1830847..1831164) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" gene complement(1830847..1831164) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" promotor_-10 complement(1831208..1831227) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1831216) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" promotor_-35 complement(1831242..1831249) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1831301..1831576) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" gene complement(1831301..1831576) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" downshifts complement(1831302) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" promotor_-35 1831572..1831577 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1831593..1831611 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1831603..1831622) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1831613 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" upshifts complement(1831616) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" promotor_-35 complement(1831635..1831644) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1831665..1832078 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" gene 1831665..1832078 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" upshifts 1832129 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" misc_feature 1832135..1832154 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1832178..1833122 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" gene 1832178..1833122 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" promotor_-35 1833102..1833110 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1833121..1833139 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1833123 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" CDS 1833162..1833383 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" gene 1833162..1833383 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" downshifts complement(1833173) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" promotor_-10 complement(1833235..1833239) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833239) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1833254..1833259) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1833383 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" CDS 1833579..1833851 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" gene 1833579..1833851 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" promotor_-35 1833867..1833874 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833888..1833907 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833890 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" CDS 1833933..1834163 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" gene 1833933..1834163 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" S_feature 1834164..1834240 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1834197 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" S_feature 1834242..1834349 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1834322..1834329 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1834343..1834362 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1834351 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" CDS 1834406..1834798 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" gene 1834406..1834798 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" CDS 1834758..1836860 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" gene 1834758..1836860 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" CDS 1836878..1837867 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" gene 1836878..1837867 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" downshifts 1837827 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" S_feature complement(1837881..1838540) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1837896) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" CDS 1837917..1838537 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" gene 1837917..1838537 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" downshifts 1838518 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" promotor_-35 1838553..1838557 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1838575..1838942 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1838575 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" promotor_-10 1838579..1838596 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1838585) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" CDS complement(1838601..1839368) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" gene complement(1838601..1839368) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" promotor_-10 complement(1839377..1839396) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839400) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" promotor_-35 complement(1839409..1839418) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1839522..1839527 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839543..1839561 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839543 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1839825..1839830 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1839847..1839865 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1839851..1839991 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1839851 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" CDS 1839992..1840960 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" gene 1839992..1840960 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" downshifts 1840929 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" promotor_-35 1841024..1841032 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1841039 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" promotor_-10 1841043..1841062 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1841093..1842355 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" gene 1841093..1842355 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" CDS 1842373..1843638 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" gene 1842373..1843638 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" promotor_-35 1843686..1843693 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1843708..1843727 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1843720 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1843748..1844155 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" gene 1843748..1844155 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" downshifts complement(1843754) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" misc_feature 1844136..1844154 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1844161 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" downshifts complement(1844214) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" CDS 1844214..1845548 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" gene 1844214..1845548 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" downshifts 1845525 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" S_feature 1845570..1845830 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1845805..1845812 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1845827..1845846 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1845832 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1845876..1846166 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" gene 1845876..1846166 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" S_feature 1846167..1846411 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1846412..1846756 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" gene 1846412..1846756 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" downshifts 1846734 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" CDS 1846887..1847138 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" gene 1846887..1847138 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" promotor_-35 1847164..1847171 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1847182..1847201 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1847195..1847324 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1847195 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" CDS 1847325..1847759 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" gene 1847325..1847759 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" CDS 1847829..1848620 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" gene 1847829..1848620 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" promotor_-10 complement(1847937..1847956) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847945) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1847972..1847974) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1848616 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" downshifts 1848682 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1848893..1848901 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1848913..1848931 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1848924 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" CDS 1848955..1849467 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" gene 1848955..1849467 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" promotor_-35 1849914..1849920 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1849914 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" promotor_-35 1849916..1849920 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849934..1849953 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1849934..1849953 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1849958..1850026 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1849958 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" CDS 1850027..1850668 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" gene 1850027..1850668 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" S_feature 1850669..1850756 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1850757..1851110 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" gene 1850757..1851110 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" CDS 1851154..1851429 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" gene 1851154..1851429 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" downshifts complement(1851530) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" CDS 1851542..1851706 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" gene 1851542..1851706 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" S_feature 1851707..1851845 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1851846..1852316 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" gene 1851846..1852316 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" S_feature 1852317..1853140 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1852480..1852498) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852498) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1852514..1852519) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1853141..1854532 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" gene 1853141..1854532 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" CDS 1854563..1856164 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" gene 1854563..1856164 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" S_feature complement(1854679..1854984) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1854979..1854998) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854984) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" promotor_-35 complement(1855012..1855020) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1856162 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" CDS complement(1856301..1857455) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" gene complement(1856301..1857455) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" downshifts complement(1856304) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" S_feature complement(1857354..1857532) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1857500..1857506 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1857515..1857534) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1857516..1857532 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1857526 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1857532) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" promotor_-35 complement(1857549..1857552) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1857559..1857566 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1857581..1857600 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1857592..1857696 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1857593 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" CDS 1857697..1859034 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" gene 1857697..1859034 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" S_feature 1859035..1859109 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1859066 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" CDS 1859185..1860684 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" gene 1859185..1860684 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" S_feature 1860685..1861000 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1860958 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" CDS complement(1861167..1861802) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" gene complement(1861167..1861802) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" promotor_-10 complement(1861839..1861858) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861848) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" promotor_-35 complement(1861873..1861880) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1861990..1861997 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1862012..1862031 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1862014..1862212 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1862014 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" CDS 1862213..1863628 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" gene 1862213..1863628 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" downshifts 1863618 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1863721) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" CDS complement(1863730..1864914) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" gene complement(1863730..1864914) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" S_feature complement(1864915..1864994) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1864987..1865005) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864998) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" promotor_-35 complement(1865021..1865026) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1865306..1865313 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865328..1865347 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865336 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" CDS 1865378..1865839 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" gene 1865378..1865839 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" CDS 1865869..1866303 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" gene 1865869..1866303 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" S_feature complement(1866052..1866357) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1866150 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" S_feature 1866304..1867400 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1866359..1866644) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1866402) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1866639..1866658) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866644) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" promotor_-35 complement(1866670..1866675) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1866906) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" CDS complement(1866906..1867166) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" gene complement(1866906..1867166) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" promotor_-10 complement(1867187..1867206) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867197) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" promotor_-35 complement(1867219..1867228) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1867401..1867526 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" gene 1867401..1867526 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo S_feature 1867527..1867643 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1867570..1867734 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" gene 1867570..1867734 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" promotor_-35 1867618..1867627 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867641..1867660 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1867645..1867955 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1867645 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" promotor_-35 1867936..1867943 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867957..1867976 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867957 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" CDS 1868008..1868847 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" gene 1868008..1868847 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" promotor_-10 complement(1868030..1868049) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868051) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1868064..1868067) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1868807 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" downshifts complement(1868953) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" S_feature complement(1868954..1869260) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1868970..1869257) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" gene complement(1868970..1869257) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" downshifts complement(1868997) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" promotor_-35 1869084..1869092 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869106..1869125 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1869108 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" S_feature 1869119..1869279 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1869251 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" CDS complement(1869300..1870022) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" gene complement(1869300..1870022) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" downshifts complement(1869305) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1870047..1870066) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1870055) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" S_feature complement(1870057..1870181) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1870182..1870538) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" gene complement(1870182..1870538) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" promotor_-10 complement(1870562..1870581) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870579) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" promotor_-35 complement(1870597..1870601) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1870778) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" CDS complement(1870784..1870984) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" gene complement(1870784..1870984) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" downshifts 1870967 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" promotor_-10 complement(1871006..1871025) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871018) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" promotor_-35 complement(1871038..1871047) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1871159..1871347) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" gene complement(1871159..1871347) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" downshifts complement(1871175) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" misc_feature complement(1871316..1871323) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1871329) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-10 complement(1871376..1871395) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871394) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-35 complement(1871410..1871417) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1871426..1871563 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" gene 1871426..1871563 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" promotor_-35 1871457..1871462 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871477..1871495 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1871495..1871597 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1871495 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" CDS 1871598..1871996 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" gene 1871598..1871996 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" S_feature 1871997..1872801 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1872061..1872495) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" gene complement(1872061..1872495) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" downshifts complement(1872077) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1872525..1872544) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872541) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" promotor_-35 complement(1872558..1872565) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1872802..1872990 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" gene 1872802..1872990 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" S_feature 1872991..1873076 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1873035 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" promotor_-35 1873105..1873111 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1873123..1873282 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1873123 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" promotor_-10 1873125..1873136 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1873283..1874845 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" gene 1873283..1874845 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" promotor_-10 complement(1873586..1873605) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873595) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1873620..1873627) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1874875..1875966 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" gene 1874875..1875966 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" CDS 1875956..1877170 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" gene 1875956..1877170 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" promotor_-35 1877248..1877255 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1877270..1877289 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1877281 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" CDS 1877317..1878123 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" gene 1877317..1878123 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" S_feature complement(1877931..1879029) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1878128..1878745 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" gene 1878128..1878745 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" CDS 1878742..1880382 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" gene 1878742..1880382 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" promotor_-10 complement(1879016..1879035) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879029) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" promotor_-35 complement(1879049..1879057) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1880022..1880788) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1880419..1880784 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" gene 1880419..1880784 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" downshifts 1880761 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" misc_RNA complement(1880781..1881061) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene complement(1880781..1881061) /gene="surA" /locus_tag="BSU_misc_RNA_72" S_feature complement(1880790..1880921) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1880833) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1880881..1880890 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1880903..1880912) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1880904..1880923 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1880909 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" S_feature 1880911..1881009 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1880921) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" S_feature complement(1880923..1881053) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1881010..1881768 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" gene 1881010..1881768 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" promotor_-35 1881036 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881038 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1881043 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" promotor_-10 complement(1881059..1881078) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881060) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" promotor_-35 complement(1881093..1881100) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1881583..1881794) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1881747 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" S_feature 1881792..1882411 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1881795..1882334) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" gene complement(1881795..1882334) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" promotor_-10 complement(1882335..1882349) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882341) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" promotor_-35 complement(1882363..1882369) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1882389..1882398 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1882411..1882426 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1882413 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" CDS 1882452..1882886 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" gene 1882452..1882886 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" CDS 1882744..1883091 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" gene 1882744..1883091 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" S_feature 1882887..1883219 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1883178..1883187 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1883199..1883214 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1883221..1883399 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1883221 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" misc_RNA 1883290..1883369 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 1883290..1883369 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" downshifts 1883356 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" CDS complement(1883428..1884045) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" gene complement(1883428..1884045) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" downshifts complement(1883429) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(1884069..1884088) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884090) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" promotor_-35 complement(1884102..1884109) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1884125..1884132 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1884144 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" promotor_-10 1884146..1884165 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1884195..1884512 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" gene 1884195..1884512 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" promotor_-10 complement(1884212..1884230) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884215) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1884244..1884251) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1884531..1885184 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " gene 1884531..1885184 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" promotor_-35 1885187..1885194 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1885208..1885227 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1885221 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" CDS 1885248..1885481 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" gene 1885248..1885481 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" S_feature 1885482..1885617 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1885585..1885592 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1885606..1885625 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1885619 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" CDS 1885650..1887653 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" gene 1885650..1887653 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" misc_feature complement(1885854..1885873) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1885871) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1887643 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" S_feature complement(1887655..1888313) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1887753 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" misc_feature 1887754..1887773 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1887806..1888252 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" gene 1887806..1888252 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" misc_feature 1888276..1888295 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1888284 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" promotor_-10 complement(1888295..1888312) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888313) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" promotor_-35 complement(1888331..1888335) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1888338..1888556 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" gene 1888338..1888556 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" downshifts 1888568 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" S_feature 1888613..1888912 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1888630..1888803) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" gene complement(1888630..1888803) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" downshifts complement(1888643) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1888841..1888860) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888848) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" promotor_-35 complement(1888874..1888881) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1888883..1888891 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1888903..1888922) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1888903..1888921 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1888914..1889022 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1888914 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" upshifts complement(1888915) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" promotor_-35 complement(1888937..1888944) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1889023..1889730 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" gene 1889023..1889730 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" promotor_-35 1889750..1889757 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1889769..1889788 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1889777 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" CDS 1889819..1890181 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" gene 1889819..1890181 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" promotor_-35 1890199..1890202 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1890217..1890236 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1890228 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" CDS 1890260..1890751 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" gene 1890260..1890751 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" downshifts 1890747 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" CDS complement(1890782..1891210) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" gene complement(1890782..1891210) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" downshifts complement(1890799) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1891228..1891247) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891240) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" S_feature complement(1891242..1891327) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1891261..1891268) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1891298..1891307 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1891317..1891426 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1891317 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" promotor_-10 1891320..1891339 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1891322..1891341) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891327) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" S_feature complement(1891329..1891412) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1891356..1891359) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1891383 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" CDS complement(1891444..1891836) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" gene complement(1891444..1891836) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" downshifts complement(1891457) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" promotor_-35 1891679..1891684 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1891700..1891718 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1891704 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" promotor_-35 1891814..1891818 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1891828..1891842 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1891843..1891862) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1891845 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1891858) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" promotor_-35 complement(1891876..1891885) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1891917..1892063) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" gene complement(1891917..1892063) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" downshifts complement(1891938) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" CDS complement(1892095..1892241) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" gene complement(1892095..1892241) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" S_feature 1892241..1892374 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1892241 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 1892252..1892254 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1892257..1892268) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892271) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" promotor_-35 complement(1892283..1892289) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1892364..1892371 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1892376..1892468 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1892376 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1892386..1892405 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1892427) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" CDS 1892469..1895198 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" gene 1892469..1895198 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" misc_feature complement(1892489..1892493) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1892493) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1895199..1895269 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1895270..1895782 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" gene 1895270..1895782 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" downshifts 1895739 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" promotor_-35 1895808..1895814 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1895827 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1895829..1895840 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1895863..1895988 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" gene 1895863..1895988 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" downshifts complement(1895881) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" promotor_-35 1896002..1896008 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896023..1896034 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1896025 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" CDS 1896053..1896199 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" gene 1896053..1896199 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" CDS 1896236..1896487 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" gene 1896236..1896487 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" downshifts 1896465 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" promotor_-35 1896508..1896513 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896527..1896546 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1896531..1896622 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1896531 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" CDS 1896623..1896988 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" gene 1896623..1896988 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" CDS 1897004..1897303 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" gene 1897004..1897303 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" downshifts 1897279 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" CDS complement(1897334..1897621) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" gene complement(1897334..1897621) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" downshifts complement(1897355) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" downshifts complement(1897421) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1897651..1897670) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1897663) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" promotor_-35 complement(1897686..1897693) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1897709..1898290) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" gene complement(1897709..1898290) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" S_feature 1898291..1898421 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1898316..1898335) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1898333) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" promotor_-35 1898406..1898409 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1898423 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" promotor_-10 1898425..1898444 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1898460..1898867 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" gene 1898460..1898867 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" downshifts 1898863 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" promotor_-35 1898929..1898932 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1898947..1898966 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1898951..1899265 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1898951 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" CDS 1899266..1901233 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" gene 1899266..1901233 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" CDS 1901237..1903657 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" gene 1901237..1903657 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" downshifts 1903637 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" S_feature complement(1903665..1903854) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1903704..1903880) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" gene complement(1903704..1903880) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo downshifts complement(1903708) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" CDS complement(1903855..1904265) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" gene complement(1903855..1904265) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo promotor_-10 complement(1904238..1904257) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904241) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1904272..1904279) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1904306..1904325) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904307) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1904340..1904347) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1904354..1904373) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904365) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1904387..1904396) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1904613..1904618 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1904631..1904650 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1904636 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" S_feature 1904649..1904713 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1904714..1906111 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" gene 1904714..1906111 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" downshifts 1906100 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" downshifts 1906145 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" S_feature complement(1906201..1906947) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1906324..1906331 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1906343 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" promotor_-10 1906344..1906363 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1906414..1907913 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" gene 1906414..1907913 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" promotor_-10 complement(1906946..1906965) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906969) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" promotor_-35 complement(1906979..1906988) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1907861 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" CDS 1907981..1908244 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" gene 1907981..1908244 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" downshifts complement(1908503) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" CDS complement(1908503..1909771) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" gene complement(1908503..1909771) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" S_feature complement(1909772..1909901) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1909902..1911443) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" gene complement(1909902..1911443) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" S_feature complement(1911444..1911765) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1911755..1911774) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911766) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" promotor_-35 complement(1911789..1911792) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1911992..1911999 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1912012..1912031 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1912019 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1912038..1912484 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" gene 1912038..1912484 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" CDS 1912491..1913384 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" gene 1912491..1913384 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" misc_feature 1913001..1913020 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1913009 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" CDS 1913457..1914053 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" gene 1913457..1914053 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" downshifts 1914043 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" CDS complement(1914102..1915301) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" gene complement(1914102..1915301) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" S_feature complement(1915302..1915373) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1915361..1915372) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915373) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" promotor_-35 complement(1915387..1915393) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915471..1917006) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" gene complement(1915471..1917006) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" downshifts complement(1915483) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" CDS complement(1917017..1917799) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" gene complement(1917017..1917799) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" CDS complement(1917820..1918719) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" gene complement(1917820..1918719) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" CDS complement(1918734..1918955) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" gene complement(1918734..1918955) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" CDS complement(1918970..1920304) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" gene complement(1918970..1920304) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" CDS complement(1920314..1921963) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" gene complement(1920314..1921963) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" promotor_no_box 1920363..1920463 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1920423 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1922007..1923149) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" gene complement(1922007..1923149) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" promotor_-10 complement(1923168..1923186) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923185) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" promotor_-35 complement(1923202..1923207) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1923240..1923545) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " gene complement(1923240..1923545) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" CDS complement(1923535..1923708) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" gene complement(1923535..1923708) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" CDS complement(1923816..1925348) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" gene complement(1923816..1925348) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" downshifts complement(1923827) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(1925383..1925402) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925383) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" promotor_-35 complement(1925415..1925424) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925484..1925876) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" gene complement(1925484..1925876) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" downshifts complement(1925515) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1925904..1925915) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925911) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" promotor_-35 complement(1925929..1925935) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925987..1929826) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" gene complement(1925987..1929826) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" downshifts complement(1925999) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" CDS complement(1929834..1940645) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" gene complement(1929834..1940645) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" promotor_-35 1932854..1932857 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1932874..1932893 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1932875 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1940670..1948337) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" gene complement(1940670..1948337) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" CDS complement(1948354..1956036) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" gene complement(1948354..1956036) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" downshifts complement(1952025) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" upshifts complement(1952069) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" promotor_-10 complement(1952071..1952075) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1952093..1952096) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1952372..1952376 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1952389 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1952392..1952411 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1956061..1963746) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" gene complement(1956061..1963746) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" S_feature complement(1963747..1963855) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1963840..1963859) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963855) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" promotor_-35 complement(1963873..1963880) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1964129..1965604) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" gene complement(1964129..1965604) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" downshifts complement(1964141) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" CDS complement(1965638..1966615) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" gene complement(1965638..1966615) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" promotor_-10 complement(1966644..1966662) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966656) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" promotor_-35 complement(1966674..1966682) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1966749..1968140) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" gene complement(1966749..1968140) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" downshifts complement(1966763) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" downshifts 1966909 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" promotor_-35 1967930..1967936 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1967950..1967968 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1967961..1968294 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1967961 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" S_feature complement(1968141..1968245) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1968205..1968305) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1968245) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" promotor_-35 1968267..1968272 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968288..1968306 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968296 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" promotor_-35 1968354..1968361 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968374..1968393 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968377 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" CDS 1968426..1968971 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" gene 1968426..1968971 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" downshifts 1968955 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" tRNA complement(1969065..1969137) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(1969065..1969137) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" downshifts complement(1969163) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" CDS complement(1969190..1969735) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" gene complement(1969190..1969735) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" promotor_-10 complement(1969775..1969794) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969789) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" promotor_-35 complement(1969808..1969815) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1970051..1970281) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" gene complement(1970051..1970281) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" downshifts complement(1970065) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1970307..1970326) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970319) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" promotor_-35 complement(1970338..1970344) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1970373..1970392) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1970383) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1970396..1970403 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970417..1970436 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970421 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" CDS 1970466..1972229 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" gene 1970466..1972229 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" downshifts 1972210 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" CDS complement(1972330..1973187) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" gene complement(1972330..1973187) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" promotor_-10 complement(1973233..1973252) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973253) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" promotor_-35 complement(1973266..1973273) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1973315..1974304 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" gene 1973315..1974304 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" S_feature complement(1973371..1974329) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1974361..1975842) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" gene complement(1974361..1975842) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" downshifts complement(1974374) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" CDS complement(1975859..1980421) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" gene complement(1975859..1980421) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" promotor_no_box 1978882..1978982 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1978942 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1980422..1980493) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1980473..1980492) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1980490..1980497 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1980493) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" promotor_-35 complement(1980507..1980514) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1980509 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" promotor_-10 1980512..1980531 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1980568..1981470 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" gene 1980568..1981470 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" downshifts 1981450 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" CDS complement(1981522..1982637) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" gene complement(1981522..1982637) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" CDS complement(1982634..1983527) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" gene complement(1982634..1983527) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" promotor_-10 complement(1983532..1983551) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1983540 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" upshifts complement(1983550) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1983565..1983571) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1983580..1983598) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983598) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1983614..1983619) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983675..1984043) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" gene complement(1983675..1984043) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" promotor_-10 complement(1984078..1984096) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1984101) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" S_feature complement(1984103..1984222) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1984108..1984116) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1984214..1984233) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984222) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" S_feature complement(1984224..1984320) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1984248..1984255) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984343..1985059) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" gene complement(1984343..1985059) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" downshifts complement(1984365) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" promotor_-10 complement(1985097..1985116) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985106) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" promotor_-35 complement(1985132..1985135) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1985160..1985166 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1985180..1985198 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1985185 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" CDS 1985210..1985515 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " gene 1985210..1985515 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" downshifts 1985499 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" CDS 1985586..1986356 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" gene 1985586..1986356 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" promotor_-35 1986338..1986345 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1986357 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" promotor_-10 1986360..1986379 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1986400..1986933 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" gene 1986400..1986933 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" S_feature 1986934..1987019 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1986976 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" CDS complement(1987012..1988256) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" gene complement(1987012..1988256) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" S_feature 1987021..1987760 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1987026) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" S_feature complement(1988257..1988349) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1988350..1989813) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" gene complement(1988350..1989813) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" CDS complement(1989831..1990865) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" gene complement(1989831..1990865) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" S_feature complement(1990877..1990948) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1990920) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" misc_RNA complement(1990949..1991040) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1990949..1991040) /gene="mswF" /locus_tag="BSU_misc_RNA_31" promotor_-10 complement(1991068..1991087) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991080) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" promotor_-35 complement(1991102..1991109) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1991122..1991129 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1991143..1991162 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1991147 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" CDS 1991189..1993231 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" gene 1991189..1993231 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" promotor_-35 1993239..1993248 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1993261..1993276 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1993264 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1993298..1993591 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" gene 1993298..1993591 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" downshifts 1993571 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" S_feature complement(1993616..1993963) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1993647) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" CDS complement(1993964..1994368) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" gene complement(1993964..1994368) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" S_feature complement(1994369..1994464) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1994454..1994469) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1994454..1994573) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" gene complement(1994454..1994573) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" upshifts complement(1994464) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" promotor_-35 complement(1994482..1994491) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1994569..1994575 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994589..1994600 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1994600..1994808 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1994600 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1994643..1994765 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" gene 1994643..1994765 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" CDS 1994809..1995102 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" gene 1994809..1995102 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" S_feature 1995103..1995196 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1995153 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" CDS complement(1995218..1996903) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" gene complement(1995218..1996903) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" downshifts complement(1995230) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" S_feature complement(1996904..1996991) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1996983..1997001) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996991) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" promotor_-35 complement(1997015..1997022) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1997160..1997169 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1997179 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" promotor_-10 1997182..1997201 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1997228..1998679 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" gene 1997228..1998679 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" downshifts 1998655 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" CDS complement(1998716..1999414) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" gene complement(1998716..1999414) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" downshifts complement(1998731) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" promotor_-10 complement(1999449..1999468) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999468) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" S_feature complement(1999470..1999683) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1999482..1999489) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999684..2000361) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" gene complement(1999684..2000361) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" S_feature complement(2000362..2002851) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 2000534..2001571 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" gene 2000534..2001571 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" promotor_-35 2001768..2001774 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2001789..2001800 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2001801 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" CDS 2001828..2002511 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" gene 2001828..2002511 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" CDS complement(2002852..2003157) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " gene complement(2002852..2003157) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" S_feature complement(2003158..2003259) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(2003238..2003257) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003259) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" promotor_-35 complement(2003272..2003279) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2003287..2003389) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(2003329) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" CDS complement(2003390..2004568) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" gene complement(2003390..2004568) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" promotor_-10 complement(2004594..2004613) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004613) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" promotor_-35 complement(2004627..2004636) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2004691..2005179) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" gene complement(2004691..2005179) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" downshifts complement(2004716) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" CDS complement(2005204..2005359) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" gene complement(2005204..2005359) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" CDS complement(2005399..2006154) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" gene complement(2005399..2006154) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" promotor_-35 2006407..2006412 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006428..2006446 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2006443 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" CDS 2006462..2006818 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" gene 2006462..2006818 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" CDS complement(2006777..2007016) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" gene complement(2006777..2007016) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" S_feature 2006819..2007255 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(2007017..2007118) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(2007119..2007616) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" gene complement(2007119..2007616) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" S_feature complement(2007617..2007716) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(2007717..2008628) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" gene complement(2007717..2008628) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" promotor_-10 complement(2008650..2008661) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008652) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" promotor_-35 complement(2008676..2008682) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2008912..2008919 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2008928 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" promotor_-10 2008934..2008953 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2008975..2009457 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" gene 2008975..2009457 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" CDS 2009467..2009721 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" gene 2009467..2009721 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" S_feature 2009722..2009826 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 2009827..2010621 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" gene 2009827..2010621 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" S_feature 2010622..2011632 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(2010745..2011617) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" gene complement(2010745..2011617) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" CDS 2011718..2012596 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" gene 2011718..2012596 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" S_feature complement(2012709..2012768) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(2012744) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" CDS complement(2012769..2013200) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" gene complement(2012769..2013200) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" promotor_-10 complement(2013220..2013239) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2013228) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" S_feature complement(2013230..2013463) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(2013253..2013259) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2013464..2013482) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2013464..2014096) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" gene complement(2013464..2014096) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" upshifts complement(2013470) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" promotor_-35 complement(2013498..2013503) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2014234..2014241 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2014256..2014275 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2014260 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" CDS 2014322..2015242 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" gene 2014322..2015242 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" promotor_-10 complement(2014753..2014772) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2014768) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2014787..2014794) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2015243..2015900 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(2015739..2016101) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" gene complement(2015739..2016101) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" CDS complement(2016162..2016374) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" gene complement(2016162..2016374) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo promotor_-35 2016413..2016420 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2016435..2016454 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2016438 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" CDS 2016478..2016741 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" gene 2016478..2016741 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" downshifts 2016719 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" CDS complement(2017118..2019718) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" gene complement(2017118..2019718) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" S_feature complement(2019719..2019828) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 2019744..2019751 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019766..2019785 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2019774..2020401 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 2019774 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" promotor_-10 complement(2019818..2019837) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019828) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" promotor_-35 complement(2019852..2019858) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2019874..2020333) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(2019916) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" downshifts complement(2020378) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" CDS complement(2020388..2021029) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" gene complement(2020388..2021029) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" S_feature complement(2021030..2021147) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(2021124..2021143) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021147) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" promotor_-35 complement(2021157..2021159) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021657..2021896) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" gene complement(2021657..2021896) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" downshifts complement(2021677) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" misc_feature complement(2021936..2021955) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2021943) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" promotor_-35 2022002..2022009 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2022024..2022043 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2022031 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" CDS 2022067..2022405 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" gene 2022067..2022405 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" S_feature 2022406..2023002 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(2022439..2022795) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" gene complement(2022439..2022795) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" CDS 2023003..2023368 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" gene 2023003..2023368 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" S_feature complement(2023377..2024503) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(2023420) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" CDS 2023590..2024249 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" gene 2023590..2024249 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" downshifts 2024327 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" CDS complement(2024504..2025427) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" gene complement(2024504..2025427) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" promotor_-10 complement(2025283..2025302) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025286) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" promotor_-35 complement(2025314..2025321) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2025438..2025457) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(2025459) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" promotor_-35 complement(2025472..2025479) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(2025480..2025653) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" gene complement(2025480..2025653) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" CDS 2025798..2026022 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" gene 2025798..2026022 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" CDS complement(2026026..2026481) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" gene complement(2026026..2026481) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" promotor_-35 2026541..2026548 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026563..2026582 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026567 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" CDS 2026606..2026866 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" gene 2026606..2026866 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" downshifts 2026813 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" promotor_-35 2027281..2027284 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2027298..2027317 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2027315 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2027427 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" CDS 2027644..2027784 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" gene 2027644..2027784 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo downshifts 2027781 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" promotor_-35 2027866..2027873 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2027885..2027904 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2027886 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" CDS 2027939..2029054 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" gene 2027939..2029054 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" promotor_-35 2028778..2028786 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2028795 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" promotor_-10 2028798..2028816 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2029051..2029173 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" gene 2029051..2029173 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" downshifts 2029167 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" CDS complement(2029299..2029952) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " gene complement(2029299..2029952) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo downshifts complement(2029573) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" CDS complement(2029989..2030336) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" gene complement(2029989..2030336) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo CDS complement(2030329..2030622) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" gene complement(2030329..2030622) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" upshifts 2030773 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" misc_feature 2030774..2030793 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2030831..2031166 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" gene 2030831..2031166 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" promotor_no_box complement(2031205..2031305) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(2031212) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" CDS complement(2031213..2034818) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" gene complement(2031213..2034818) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" upshifts complement(2031245) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2034819..2034963) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(2034956..2034975) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2034963) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" S_feature complement(2034965..2035050) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(2035051..2035350) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" gene complement(2035051..2035350) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo S_feature complement(2035351..2035488) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(2035466..2035484) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035488) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" promotor_-35 complement(2035498..2035504) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2035521..2035904) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" gene complement(2035521..2035904) /gene="asrE" /locus_tag="BSU_misc_RNA_74" S_feature complement(2035535..2035771) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 2035568..2035570 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2035578) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" promotor_-10 2035586..2035605 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2035591 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" S_feature 2035613..2035766 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 2035672..2035764 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" gene 2035672..2035764 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" downshifts 2035723 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2035773..2035907) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 2035789 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" downshifts complement(2035816) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" upshifts complement(2035907) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" S_feature complement(2035909..2036032) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(2035916..2035917) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2036033..2036875) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" gene complement(2036033..2036875) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" promotor_-35 2036370..2036373 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2036383 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2036389..2036393 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2036901..2036916) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(2036902) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" S_feature complement(2036904..2036986) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(2036928..2036937) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(2036988..2037074) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(2037031) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" CDS complement(2037075..2037533) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" gene complement(2037075..2037533) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" CDS complement(2037543..2039345) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" gene complement(2037543..2039345) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" promotor_-10 complement(2039369..2039388) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(2039385) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" promotor_-35 complement(2039400..2039407) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(2039447..2040004) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /translation="MTNFVHKTVNGLKSLLDEKGAIKLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" gene complement(2039447..2040004) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" S_feature complement(2040011..2040406) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 2040069..2040074 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 2040090..2040108 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 2040099 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" S_feature 2040101..2040227 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 2040132..2041568 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" gene 2040132..2041568 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" promotor_-10 complement(2040392..2040411) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2040406) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" promotor_-35 complement(2040425..2040431) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2041569..2041900 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 2041882..2041890 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2041901..2041919 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2041902..2041994 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 2041902 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" CDS 2041995..2044415 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" gene 2041995..2044415 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" S_feature complement(2044337..2044972) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 2044416..2044873 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 2044848..2044855 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044867..2044886 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2044875..2044985 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 2044875 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" misc_RNA 2044885..2044992 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" gene 2044885..2044992 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" downshifts 2044970 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" CDS complement(2045003..2045335) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" gene complement(2045003..2045335) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" downshifts complement(2045017) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" CDS complement(2045400..2046125) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" gene complement(2045400..2046125) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" CDS complement(2046140..2046883) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" gene complement(2046140..2046883) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" promotor_-10 complement(2046911..2046930) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046930) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" promotor_-35 complement(2046944..2046950) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2046961..2047536) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" gene complement(2046961..2047536) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" CDS complement(2047542..2048243) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" gene complement(2047542..2048243) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" promotor_-10 complement(2048273..2048292) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048273) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" promotor_-10 complement(2048277..2048292) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2048307..2048314) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2048307..2048314) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2048317) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" CDS complement(2048320..2048802) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" gene complement(2048320..2048802) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" misc_feature complement(2048841..2048858) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2048845) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" CDS complement(2048856..2049797) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" gene complement(2048856..2049797) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" downshifts complement(2048889) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(2049827..2049846) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2049835) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" promotor_-35 complement(2049860..2049864) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2049868..2049877 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049890..2049909 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049898 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" S_feature 2049913..2049977 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 2049949..2049954 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049970..2049988 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049979 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" CDS 2050003..2050548 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" gene 2050003..2050548 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" downshifts 2050507 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" CDS complement(2050575..2050898) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" gene complement(2050575..2050898) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" downshifts complement(2050582) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(2050919..2050938) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2050930) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" promotor_-35 complement(2050951..2050958) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2051019..2051025 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2051036 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" promotor_-10 2051040..2051059 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2051092..2051769 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" gene 2051092..2051769 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" downshifts 2051761 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" CDS complement(2051859..2052395) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" gene complement(2051859..2052395) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" downshifts complement(2051882) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2052422..2052441) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052442) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" promotor_-35 complement(2052455..2052462) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052532..2053314) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" gene complement(2052532..2053314) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" downshifts complement(2052541) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2053336..2053354) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053355) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" promotor_-35 complement(2053368..2053374) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2053411..2053418 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2053433..2053452 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2053437 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" CDS 2053485..2053982 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" gene 2053485..2053982 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" promotor_-35 2053989..2053992 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2054008..2054027 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2054010 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" CDS 2054046..2055023 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" gene 2054046..2055023 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" downshifts 2054995 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" promotor_-35 2055120..2055127 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2055142..2055161 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2055149 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" CDS 2055185..2056243 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" gene 2055185..2056243 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" S_feature 2056244..2056313 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 2056297..2056303 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2056315..2056334 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2056315 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" CDS 2056363..2057475 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" gene 2056363..2057475 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" CDS 2057494..2058093 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" gene 2057494..2058093 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" downshifts 2058031 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" downshifts 2058075 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" S_feature complement(2058115..2058613) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(2058151) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" promotor_-35 2058585..2058594 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2058597..2058615) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2058606..2058800 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 2058606 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" promotor_-10 2058607..2058626 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058613) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" promotor_-35 complement(2058632..2058637) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2058688..2059551) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" gene complement(2058688..2059551) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" downshifts complement(2058701) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" downshifts 2058757 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" downshifts complement(2058789) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" S_feature 2058802..2059569 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 2059547..2059551 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2059560..2059574 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2059571 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2059590..2059609) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059603) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" S_feature complement(2059605..2059798) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(2059621..2059627) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2059799..2061574) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" gene complement(2059799..2061574) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" S_feature complement(2061575..2061705) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(2061698..2061900) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" gene complement(2061698..2061900) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" downshifts complement(2061750) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" promotor_-10 complement(2061898..2061917) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(2061916) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" S_feature complement(2061918..2062110) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(2061930..2061937) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(2062139..2062765) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" gene complement(2062139..2062765) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" downshifts complement(2062155) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(2062799..2062818) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(2062812) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" promotor_-35 complement(2062832..2062839) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(2062915..2063406) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" gene complement(2062915..2063406) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" downshifts complement(2062924) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2063418..2063436) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(2063430) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" promotor_-35 complement(2063450..2063456) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(2063481..2063813) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" gene complement(2063481..2063813) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" S_feature complement(2063814..2064104) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 2063829..2063834 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 2063849..2063867 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 2063851 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" CDS 2063891..2064118 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" gene 2063891..2064118 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" CDS complement(2064105..2064581) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" gene complement(2064105..2064581) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" S_feature 2064119..2064626 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(2064582..2064684) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 2064599..2064604 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064619..2064637 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2064628 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" CDS 2064648..2064911 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" gene 2064648..2064911 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" promotor_-10 complement(2064664..2064683) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064684) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2064686..2065211) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(2064697..2064701) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2064916..2065149 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" gene 2064916..2065149 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" downshifts 2065136 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" CDS complement(2065235..2065579) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" gene complement(2065235..2065579) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" downshifts complement(2065256) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" S_feature complement(2065580..2065652) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(2065648..2065667) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065652) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2065654..2065757) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(2065681..2065686) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2065744..2065759) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065757) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" promotor_-35 complement(2065772..2065781) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2065900) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" CDS complement(2065936..2066139) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" gene complement(2065936..2066139) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" promotor_-10 complement(2066160..2066179) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066178) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" S_feature complement(2066180..2066246) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(2066195..2066202) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2066212..2066219 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 2066231 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" misc_feature complement(2066233..2066245) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2066233..2066252 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 2066236..2066368 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(2066257) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" CDS 2066369..2067856 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" gene 2066369..2067856 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" promotor_-10 complement(2066812..2066829) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066818) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2066842..2066850) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2067842 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 2067904..2067909 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2067925..2067943 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2067930 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" CDS 2067957..2069855 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" gene 2067957..2069855 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" promotor_-10 complement(2068900..2068919) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068908) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2068933..2068942) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2069845..2070690 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" gene 2069845..2070690 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" S_feature 2070691..2072197 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(2070723..2072060) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" gene complement(2070723..2072060) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" downshifts complement(2070734) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" promotor_-10 complement(2072088..2072107) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072103) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" S_feature complement(2072105..2073263) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(2072122..2072129) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2072181..2072184 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2072199..2072218 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2072199 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" CDS 2072279..2073244 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" gene 2072279..2073244 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" downshifts 2073232 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" CDS complement(2073294..2074547) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" gene complement(2073294..2074547) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" downshifts complement(2073308) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" CDS complement(2074563..2077397) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" gene complement(2074563..2077397) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" promotor_-10 complement(2077492..2077511) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077507) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" S_feature complement(2077509..2077625) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(2077526..2077533) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2077626..2079542) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" gene complement(2077626..2079542) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" CDS complement(2079553..2080467) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" gene complement(2079553..2080467) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" promotor_-10 complement(2080471..2080490) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(2080486) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" promotor_-35 complement(2080507..2080511) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(2080531..2081121) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" gene complement(2080531..2081121) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" CDS complement(2081214..2082458) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" gene complement(2081214..2082458) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" downshifts complement(2081216) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" promotor_-10 complement(2082521..2082539) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082534) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" S_feature complement(2082536..2082756) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(2082552..2082559) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2082742..2082760) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082756) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" promotor_-35 complement(2082772..2082780) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2082840..2084057) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" gene complement(2082840..2084057) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" downshifts complement(2082866) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2084090..2084109) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084098) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" promotor_-35 complement(2084123..2084130) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2084293..2084916) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" gene complement(2084293..2084916) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" S_feature complement(2084917..2085067) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 2084943..2084949 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2084955 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" promotor_-10 2084963..2084974 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2084981..2084989 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2084997..2085097 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2085001..2085019 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2085012 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2085050..2085068) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2085057..2085142 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 2085057 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" upshifts complement(2085067) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" promotor_-35 complement(2085084..2085090) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2085118..2085125 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2085138..2085157 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2085144 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" CDS 2085182..2086540 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" gene 2085182..2086540 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" promotor_-10 complement(2085524..2085535) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085529) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2085549..2085555) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2086556..2087404 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" gene 2086556..2087404 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" promotor_-10 complement(2086820..2086839) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086827) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2086853..2086861) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2087367 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" downshifts complement(2087399) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" CDS complement(2087430..2088095) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" gene complement(2087430..2088095) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" downshifts complement(2087444) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" CDS complement(2088114..2088464) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" gene complement(2088114..2088464) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" CDS complement(2088461..2088739) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" gene complement(2088461..2088739) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" promotor_-10 complement(2088766..2088785) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088782) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2088800..2088806) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2088815..2089711) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" gene complement(2088815..2089711) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" promotor_-35 2089553..2089562 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2089573 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" promotor_-10 2089576..2089595 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2089591..2089809 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(2089735..2089754) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2089755) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2089766..2089773) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2089810..2090283 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" gene 2089810..2090283 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" downshifts 2090280 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" CDS complement(2090318..2090554) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" gene complement(2090318..2090554) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" downshifts complement(2090326) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(2090577..2090596) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2090592) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" promotor_-35 complement(2090610..2090619) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2090639..2091973) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" gene complement(2090639..2091973) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" S_feature complement(2091974..2092109) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(2092106..2092125) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092116) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" promotor_-35 complement(2092140..2092147) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2092205..2092212 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2092227..2092246 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2092230 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" S_feature 2092231..2092337 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 2092338..2092727 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" gene 2092338..2092727 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" downshifts 2092737 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" CDS complement(2093134..2093472) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" gene complement(2093134..2093472) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" promotor_-35 2093495..2093502 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093516..2093535 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093525 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" S_feature 2093529..2093601 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(2093560..2093579) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093563) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" promotor_-35 complement(2093591..2093597) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2093602..2094210 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" gene 2093602..2094210 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" downshifts 2094200 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" CDS complement(2094253..2094855) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" gene complement(2094253..2094855) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" CDS complement(2094871..2095782) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" gene complement(2094871..2095782) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" promotor_-10 complement(2095811..2095830) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095827) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" promotor_-35 complement(2095846..2095851) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2095903..2095906 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2095921..2095940 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2095923 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" CDS 2095966..2096166 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" gene 2095966..2096166 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" CDS 2096166..2097656 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" gene 2096166..2097656 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" promotor_-10 complement(2096901..2096912) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096905) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2096926..2096932) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2097644 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" CDS complement(2097691..2099091) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" gene complement(2097691..2099091) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" downshifts complement(2097715) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" promotor_-35 2098862..2098871 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098883..2098898 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098897 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2099111..2099130) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099131) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" promotor_-35 complement(2099144..2099151) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2099190..2099199 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2099205 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" promotor_-10 2099212..2099231 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2099244..2099945 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" gene 2099244..2099945 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" promotor_-35 2099970..2099978 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099992..2100011 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099997 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" CDS 2100033..2100284 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" gene 2100033..2100284 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" downshifts 2100305 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" CDS complement(2100355..2101176) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" gene complement(2100355..2101176) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" downshifts complement(2100381) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" S_feature complement(2101177..2101258) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(2101259..2101960) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" gene complement(2101259..2101960) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" S_feature complement(2101961..2102050) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(2102035..2102054) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102050) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" promotor_-35 complement(2102070..2102074) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2102108..2102114 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2102129..2102140 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2102146 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" CDS 2102162..2102287 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" gene 2102162..2102287 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" downshifts 2102285 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" CDS complement(2102327..2102641) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" gene complement(2102327..2102641) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" downshifts complement(2102339) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2102662..2102680) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102669) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" promotor_-35 complement(2102691..2102699) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102702..2103313) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" gene complement(2102702..2103313) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" CDS complement(2103391..2103567) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" gene complement(2103391..2103567) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" downshifts complement(2103395) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" upshifts complement(2103406) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" promotor_-10 complement(2103410..2103429) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2103445..2103448) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2103581..2103599) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(2103602) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" S_feature complement(2103604..2103825) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(2103615..2103620) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 2103625..2103630 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103645..2103663 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103647 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" CDS 2103686..2103829 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" gene 2103686..2103829 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" CDS complement(2103826..2104506) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" gene complement(2103826..2104506) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" S_feature 2103830..2104841 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(2104533..2104552) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104539) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" promotor_-35 complement(2104566..2104575) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2104657..2104881) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" gene complement(2104657..2104881) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" downshifts complement(2104671) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2104922..2104941) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2104934) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" CDS complement(2104968..2105246) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" gene complement(2104968..2105246) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" CDS complement(2105243..2106658) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" gene complement(2105243..2106658) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" promotor_-35 2105914..2105917 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2105933..2105952 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2105938 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2106687..2107514) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " gene complement(2106687..2107514) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" CDS complement(2107492..2108802) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" gene complement(2107492..2108802) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" CDS complement(2108811..2109464) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " gene complement(2108811..2109464) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" CDS complement(2109449..2110138) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" gene complement(2109449..2110138) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" CDS complement(2110145..2111479) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" gene complement(2110145..2111479) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" CDS complement(2111460..2111615) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" gene complement(2111460..2111615) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" promotor_-10 complement(2111498..2111516) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111514) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" promotor_-35 complement(2111532..2111537) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2111609..2111842) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" gene complement(2111609..2111842) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" downshifts complement(2111616) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" promotor_-35 2111718..2111722 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111731..2111745 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111746 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2111747..2111766) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111756) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2111781..2111790) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2111802..2112581) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" gene complement(2111802..2112581) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" CDS complement(2112610..2113890) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" gene complement(2112610..2113890) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" promotor_-10 complement(2113258..2113276) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113274) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2113290..2113297) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2113858..2113876) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113868) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2113892..2113897) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2113955..2114260) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " gene complement(2113955..2114260) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" downshifts complement(2114088) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" promotor_-10 complement(2114284..2114303) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(2114299) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" promotor_-35 complement(2114317..2114326) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 2114396..2114405 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2114419..2114438 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2114419 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" upshifts complement(2114440) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2114442..2114456) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2114465..2114469) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2114465..2114866 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" gene 2114465..2114866 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" CDS 2114873..2115826 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" gene 2114873..2115826 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" downshifts 2115816 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" CDS complement(2115897..2117045) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" gene complement(2115897..2117045) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" downshifts complement(2115914) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" promotor_-35 2117058..2117062 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2117071..2117090) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2117078..2117097 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117080) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2117088 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2117349..2117357 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2117371..2117390 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2117374 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" CDS 2117415..2118440 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 2117415..2118440 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 2117818 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" SCAR 2117834..2117835 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 2118432 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" CDS complement(2118484..2118915) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" gene complement(2118484..2118915) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" downshifts complement(2118489) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" CDS complement(2118916..2119449) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" gene complement(2118916..2119449) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" promotor_-35 2119453..2119459 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2119470..2119580 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 2119470 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" promotor_-10 2119472..2119491 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2119477..2119496) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119497) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" promotor_-35 complement(2119512..2119513) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2119581..2120006 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" gene 2119581..2120006 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" downshifts 2119994 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" S_feature 2120039..2121270 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(2120056..2121393) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" gene complement(2120056..2121393) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" CDS complement(2121465..2121659) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" gene complement(2121465..2121659) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" downshifts complement(2121478) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" CDS complement(2121672..2122235) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" gene complement(2121672..2122235) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" CDS complement(2122245..2123012) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" gene complement(2122245..2123012) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" promotor_-10 complement(2123036..2123055) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123053) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" promotor_-35 complement(2123066..2123073) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2123090..2123671) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" gene complement(2123090..2123671) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" S_feature complement(2123672..2123787) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(2123819..2124070) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" gene complement(2123819..2124070) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" downshifts complement(2123832) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2124093..2124112) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2124107) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" CDS complement(2124156..2125424) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" gene complement(2124156..2125424) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" promotor_-10 complement(2125458..2125477) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125477) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" promotor_-35 complement(2125489..2125496) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2125631..2125650 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2125634 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" CDS 2125673..2126668 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" gene 2125673..2126668 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" CDS 2126689..2127330 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" gene 2126689..2127330 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" S_feature 2127331..2128432 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2127369..2127989) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" gene complement(2127369..2127989) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" downshifts complement(2127395) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" CDS complement(2127990..2128496) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" gene complement(2127990..2128496) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" CDS complement(2128493..2129287) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" gene complement(2128493..2129287) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" CDS complement(2129371..2129904) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" gene complement(2129371..2129904) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" downshifts complement(2129376) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" promotor_-35 2129834..2129839 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2129850..2130796 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2129852 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" promotor_-10 2129856..2129874 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2129922..2130533) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" gene complement(2129922..2130533) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" promotor_-10 complement(2130565..2130584) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130584) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" promotor_-35 complement(2130597..2130602) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2130753 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" CDS complement(2130793..2131566) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" gene complement(2130793..2131566) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" downshifts complement(2130828) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" CDS complement(2131608..2132042) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" gene complement(2131608..2132042) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" downshifts complement(2131620) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" promotor_-10 complement(2132071..2132090) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2132082) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" S_feature complement(2132084..2132148) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2132104..2132111) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2132127) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" CDS complement(2132149..2133825) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" gene complement(2132149..2133825) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" S_feature complement(2133826..2134016) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2134005..2134024) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134016) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" promotor_-35 complement(2134039..2134042) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134114..2135247) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" gene complement(2134114..2135247) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" downshifts complement(2134130) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" misc_feature complement(2135269..2135288) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2135272) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" CDS complement(2135307..2135924) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" gene complement(2135307..2135924) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" CDS complement(2135940..2136422) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" gene complement(2135940..2136422) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" S_feature complement(2136423..2136570) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2136561..2136579) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2136571) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" promotor_-35 complement(2136590..2136598) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2136624..2136633 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2136646..2136661 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2136648..2136734 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2136648 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" promotor_-35 2136697..2136704 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2136719..2136738 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2136736 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" CDS 2136765..2137670 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" gene 2136765..2137670 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" misc_feature 2137705..2137724 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2137719 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" S_feature 2137720..2137900 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2137901..2139049 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" gene 2137901..2139049 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" S_feature complement(2138070..2139099) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2139045 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2139081..2139100) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139099) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" promotor_-35 complement(2139115..2139123) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2139130..2139276 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" gene 2139130..2139276 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" promotor_-35 2139169..2139176 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139190..2139209 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2139201..2139291 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2139201 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" CDS 2139292..2139492 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" gene 2139292..2139492 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" downshifts 2139507 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" CDS complement(2139544..2139726) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" gene complement(2139544..2139726) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" S_feature 2139552..2139857 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2139561) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2139787..2139805) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2139819..2139825) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2139823) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" promotor_-35 2139833..2139839 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139854..2139865 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139859 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" CDS 2139882..2140151 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" gene 2139882..2140151 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" downshifts 2140006 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" downshifts 2140134 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" CDS complement(2140179..2140361) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" gene complement(2140179..2140361) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" downshifts complement(2140199) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" CDS complement(2140354..2141034) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" gene complement(2140354..2141034) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" S_feature complement(2141035..2141172) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2141051..2141056 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2141069..2141088 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2141074 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" CDS 2141117..2141806 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" gene 2141117..2141806 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" promotor_-10 complement(2141167) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2141170..2141186) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2141173) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" S_feature complement(2141174..2141563) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2141544..2141563) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141561) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" promotor_-35 complement(2141575..2141583) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2141806..2142204 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" gene 2141806..2142204 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" promotor_-35 2142197..2142203 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2142218..2142229 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2142229 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" CDS 2142246..2142374 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" gene 2142246..2142374 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" S_feature 2142375..2143355 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2142382..2143272) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" gene complement(2142382..2143272) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" downshifts complement(2142419) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" promotor_-10 complement(2143294..2143313) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143301) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" promotor_-35 complement(2143325..2143331) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2143329 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" CDS complement(2143373..2143519) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" gene complement(2143373..2143519) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" downshifts complement(2143389) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" upshifts complement(2143543) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" promotor_-10 complement(2143544..2143555) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2143570..2143576) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2143594..2143851) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" gene complement(2143594..2143851) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" promotor_-10 complement(2143871..2143890) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143886) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" promotor_-35 complement(2143902..2143909) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2143916..2147497) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" gene complement(2143916..2147497) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" S_feature complement(2147498..2147569) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2147559..2147578) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2147569) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" S_feature complement(2147614..2147811) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2147657) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" CDS complement(2147673..2147762) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" gene complement(2147673..2147762) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" promotor_-10 complement(2147790..2147809) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147811) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" promotor_-35 complement(2147824..2147831) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2147833..2148339) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" gene complement(2147833..2148339) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" CDS complement(2148343..2149440) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" gene complement(2148343..2149440) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" promotor_-10 complement(2149458..2149469) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149461) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" promotor_-35 complement(2149484..2149490) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2149514..2150830) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" gene complement(2149514..2150830) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" downshifts complement(2149527) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" CDS complement(2150827..2151411) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" gene complement(2150827..2151411) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" misc_RNA complement(2151500..2151600) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene complement(2151500..2151600) /gene="gswA" /locus_tag="BSU_misc_RNA_34" downshifts complement(2151507) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" S_feature complement(2151601..2151741) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2151742..2153247) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" gene complement(2151742..2153247) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" promotor_no_box complement(2153183..2153283) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2153223) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" downshifts 2153235 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" promotor_-10 complement(2153273..2153292) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153289) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" promotor_-35 complement(2153306..2153313) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2153359..2154351) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" gene complement(2153359..2154351) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" downshifts complement(2153377) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" CDS complement(2154396..2154986) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" gene complement(2154396..2154986) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" CDS complement(2154988..2155962) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" gene complement(2154988..2155962) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" CDS complement(2156000..2157019) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" gene complement(2156000..2157019) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" promotor_-10 complement(2157067..2157086) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157077) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" promotor_-35 complement(2157098..2157105) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2157140..2157147 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2157161..2157240 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2157161 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" promotor_-10 2157162..2157181 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2157241..2158068 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " gene 2157241..2158068 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" CDS 2158070..2158834 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" gene 2158070..2158834 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" downshifts 2158823 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" downshifts complement(2158865) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" CDS complement(2158875..2160800) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" gene complement(2158875..2160800) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" promotor_-10 complement(2160831..2160850) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160835) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" S_feature complement(2160837..2160901) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2160865..2160869) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2160902..2161093) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" gene complement(2160902..2161093) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" promotor_-10 complement(2161112..2161130) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2161121) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" S_feature complement(2161123..2161428) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2161146..2161151) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2161160..2161166 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161181..2161192 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161190 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" CDS 2161257..2161409 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" gene 2161257..2161409 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" downshifts 2161419 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" CDS complement(2161462..2162619) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" gene complement(2161462..2162619) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" downshifts complement(2161473) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2162707..2163107) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2162707..2163107) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" downshifts complement(2162717) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" promotor_-10 complement(2163104..2163123) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163122) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" promotor_-35 complement(2163138..2163144) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2163166..2163462) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" gene complement(2163166..2163462) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" promotor_-10 complement(2163487..2163506) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2163497) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" promotor_-35 complement(2163520..2163527) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2163540..2164169) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" gene complement(2163540..2164169) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" downshifts complement(2164135) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" CDS complement(2164171..2164398) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" gene complement(2164171..2164398) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" promotor_-10 complement(2164426..2164445) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2164441) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" S_feature complement(2164443..2164597) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2164459..2164467) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2164482..2164610) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" gene complement(2164482..2164610) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" upshifts complement(2164597) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" S_feature complement(2164599..2164710) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2164600..2164619) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2164635..2164639) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2164711..2165952) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" gene complement(2164711..2165952) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" promotor_-10 complement(2165666..2165684) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2165675) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" promotor_-35 complement(2165699..2165706) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2165968..2168217) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" gene complement(2165968..2168217) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" promotor_-10 complement(2168233..2168252) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2168249) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2168266..2168272) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2168320..2168826) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" gene complement(2168320..2168826) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" downshifts complement(2168343) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" promotor_-10 complement(2168870..2168889) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2168887) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2168903..2168910) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2168908..2168917 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168931..2168950 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168943 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" CDS 2168964..2169383 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" gene 2168964..2169383 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" S_feature 2169384..2169534 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2169404..2169781) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" gene complement(2169404..2169781) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" downshifts complement(2169437) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" S_feature 2169779..2169924 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2169811..2169829) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2169830) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" promotor_-35 complement(2169843..2169852) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2169925..2169944 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2169926 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" CDS 2169969..2170157 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" gene 2169969..2170157 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" downshifts 2170173 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" CDS complement(2170196..2170567) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" gene complement(2170196..2170567) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" downshifts complement(2170229) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2170579..2170598) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170592) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" promotor_-35 complement(2170611..2170616) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170613..2170858) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" gene complement(2170613..2170858) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" promotor_-10 complement(2170884..2170902) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170889) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" promotor_-35 complement(2170914..2170922) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2171008..2171014 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171029..2171040 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171036 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" CDS 2171057..2171161 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" gene 2171057..2171161 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" downshifts 2171143 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" CDS complement(2171186..2172148) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" gene complement(2171186..2172148) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" promotor_-35 2171316..2171325 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171337..2171352 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171337 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" S_feature 2171341..2171676 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2171647..2171651 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171667..2171686 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2171678..2172188 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2171678 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" S_feature complement(2172149..2172605) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2172189..2172809 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" gene 2172189..2172809 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" promotor_-10 complement(2172594..2172605) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2172605) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" promotor_-35 complement(2172620..2172626) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2172831..2175575 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" gene 2172831..2175575 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" downshifts complement(2175245) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" downshifts 2175561 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" CDS complement(2175651..2176145) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" gene complement(2175651..2176145) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" downshifts complement(2175664) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" CDS complement(2176142..2176801) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" gene complement(2176142..2176801) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" CDS complement(2176820..2177518) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" gene complement(2176820..2177518) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" S_feature complement(2177519..2177610) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2177611..2178903) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" gene complement(2177611..2178903) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" S_feature complement(2178904..2178965) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2178965..2178984) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178965) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2178999..2179006) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2179047..2180228) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" gene complement(2179047..2180228) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" downshifts complement(2179051) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" CDS complement(2180251..2180736) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" gene complement(2180251..2180736) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" promotor_-10 complement(2180684..2180703) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180701) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2180716..2180723) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2180745..2180915) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" gene complement(2180745..2180915) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" S_feature complement(2180916..2180987) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2180949..2180955 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2180970..2180989) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2180970..2180981 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2180977..2181051 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2180977 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2180987) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" S_feature complement(2180989..2181057) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2181005..2181011) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2181021 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" CDS complement(2181058..2183853) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" gene complement(2181058..2183853) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" promotor_-35 2181526..2181530 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2181527 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2181532..2181536 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2182183..2182198) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2182197) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2182211..2182220) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2183854..2183978) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2183979..2184362) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" gene complement(2183979..2184362) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" CDS complement(2184364..2185224) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" gene complement(2184364..2185224) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" CDS complement(2185226..2186059) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" gene complement(2185226..2186059) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" S_feature complement(2186060..2186267) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2186262..2186281) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2186267) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2186298..2186302) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2186305..2187282) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" gene complement(2186305..2187282) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" CDS complement(2187267..2188460) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" gene complement(2187267..2188460) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" CDS complement(2188465..2189598) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" gene complement(2188465..2189598) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" CDS complement(2189595..2190305) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" gene complement(2189595..2190305) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" CDS complement(2190298..2190711) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" gene complement(2190298..2190711) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" CDS complement(2190727..2191530) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" gene complement(2190727..2191530) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" CDS complement(2191542..2191877) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" gene complement(2191542..2191877) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" promotor_-10 complement(2191897..2191916) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2191907) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2191930..2191937) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2191946..2191953 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2191962..2191981) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2191967..2191986 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191973 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" upshifts complement(2191981) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" CDS 2192017..2192889 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" gene 2192017..2192889 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" CDS complement(2192931..2193725) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" gene complement(2192931..2193725) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" downshifts complement(2192956) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" S_feature complement(2193726..2193793) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2193794..2194351) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" gene complement(2193794..2194351) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" S_feature complement(2194352..2194431) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2194476) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" CDS complement(2194498..2195265) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" gene complement(2194498..2195265) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" CDS complement(2195300..2195974) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" gene complement(2195300..2195974) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" CDS complement(2195976..2196479) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" gene complement(2195976..2196479) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" downshifts 2196488 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" promotor_-10 complement(2196543..2196562) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2196543) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" promotor_-35 complement(2196577..2196584) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2196622..2197068) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" gene complement(2196622..2197068) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" downshifts 2197071 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" CDS complement(2197123..2197662) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" gene complement(2197123..2197662) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" downshifts complement(2197136) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2197695..2197713) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2197706) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" promotor_-35 complement(2197725..2197733) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2197734..2199005) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" gene complement(2197734..2199005) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" S_feature complement(2199006..2199073) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2199070..2199089) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199073) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" promotor_-35 complement(2199103..2199110) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2199140..2199159) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2199146) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" S_feature complement(2199148..2199292) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2199170..2199177) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2199274..2199292) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2199292) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2199308..2199313) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2199341..2200627) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" gene complement(2199341..2200627) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" downshifts complement(2199364) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" CDS complement(2200638..2201753) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" gene complement(2200638..2201753) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" CDS complement(2201802..2202884) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" gene complement(2201802..2202884) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" CDS complement(2202895..2203698) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" gene complement(2202895..2203698) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" promotor_-10 complement(2203383..2203402) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2203400) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2203414..2203421) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2203691..2204893) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" gene complement(2203691..2204893) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" CDS complement(2204874..2205521) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" gene complement(2204874..2205521) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" downshifts complement(2204968) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" misc_feature complement(2205144..2205147) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2205144) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" downshifts complement(2205364) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" CDS complement(2205526..2206275) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" gene complement(2205526..2206275) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo misc_feature complement(2205559..2205561) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2205562) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2206268..2207284) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" gene complement(2206268..2207284) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" CDS complement(2207256..2208803) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" gene complement(2207256..2208803) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" S_feature complement(2208882..2209013) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2208925) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2209004..2209023) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2209013) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2209019..2209402) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" gene complement(2209019..2209402) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" promotor_-35 complement(2209038..2209045) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2209399..2210487) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" gene complement(2209399..2210487) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" promotor_-10 complement(2209528..2209543) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2209541) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2209556..2209564) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2210487..2211659) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" gene complement(2210487..2211659) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" promotor_-10 complement(2211694..2211713) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2211711) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2211726..2211733) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2211734..2212504) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" gene complement(2211734..2212504) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" promotor_-10 complement(2212530..2212549) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2212547) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2212561..2212567) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2212579..2212740) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2212622) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" CDS complement(2212741..2213190) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" gene complement(2212741..2213190) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" promotor_-10 complement(2213233..2213252) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2213240) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2213265..2213272) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2213306..2214352) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" gene complement(2213306..2214352) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" CDS complement(2214294..2214995) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" gene complement(2214294..2214995) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" CDS complement(2215002..2215757) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" gene complement(2215002..2215757) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" S_feature complement(2215758..2215843) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2215832..2215851) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2215843) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2215862..2215869) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2215921..2216148) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" gene complement(2215921..2216148) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" downshifts complement(2215942) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" CDS complement(2216170..2216742) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" gene complement(2216170..2216742) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" promotor_-10 complement(2216771..2216790) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2216781) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" S_feature complement(2216783..2216866) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2216803..2216809) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2216911) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" CDS complement(2216930..2217208) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" gene complement(2216930..2217208) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" S_feature complement(2217209..2217434) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2217416..2217435) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2217434) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2217452..2217457) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2217582..2219060) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" gene complement(2217582..2219060) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" downshifts complement(2217595) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" S_feature complement(2219061..2219222) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2219209..2219227) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2219234) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" CDS complement(2219241..2219975) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" gene complement(2219241..2219975) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" promotor_-35 complement(2219242..2219247) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2219267) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" CDS complement(2219997..2220200) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" gene complement(2219997..2220200) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" promotor_-10 complement(2220236..2220255) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220257) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" promotor_-35 complement(2220269..2220276) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2220322..2220521) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2220365) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2220496..2220515) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220521) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" promotor_-35 complement(2220529..2220538) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220538..2221575) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" gene complement(2220538..2221575) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" CDS complement(2221593..2222903) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" gene complement(2221593..2222903) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" S_feature complement(2222904..2223028) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2223014..2223033) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223028) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2223048..2223051) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223057..2223251) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" gene complement(2223057..2223251) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" CDS complement(2223248..2224141) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" gene complement(2223248..2224141) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" CDS complement(2224138..2224737) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" gene complement(2224138..2224737) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" promotor_-35 2224610..2224616 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2224625..2224808 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2224627 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" promotor_-10 2224630..2224641 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2224748..2224766) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224767) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2224782..2224787) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2224815..2224946 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " gene 2224815..2224946 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" downshifts 2224934 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" CDS complement(2224989..2226038) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" gene complement(2224989..2226038) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" downshifts complement(2225009) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" downshifts complement(2225913) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" CDS complement(2226051..2227199) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" gene complement(2226051..2227199) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" misc_feature 2226380..2226383 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2226407 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2226473 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" downshifts 2227177 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" S_feature complement(2227200..2227339) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2227338..2227357) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227339) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" S_feature complement(2227341..2227431) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2227372..2227379) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2227432..2228106) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" gene complement(2227432..2228106) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" S_feature complement(2228107..2228184) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2228185..2228361) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" gene complement(2228185..2228361) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" promotor_-10 complement(2228373..2228391) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228390) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2228406..2228412) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2228406..2229059) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " gene complement(2228406..2229059) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" promotor_-10 complement(2229089..2229108) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2229102) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2229124..2229128) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2229152..2230504) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" gene complement(2229152..2230504) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" downshifts complement(2229167) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" CDS complement(2230539..2231456) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" gene complement(2230539..2231456) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" downshifts complement(2230927) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" misc_feature complement(2231078..2231085) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2231081) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" promotor_-10 complement(2231494..2231505) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231503) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" promotor_-35 complement(2231519..2231525) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231595..2232251) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" gene complement(2231595..2232251) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" downshifts complement(2231609) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2232276..2232295) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2232291) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" CDS complement(2232371..2233345) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" gene complement(2232371..2233345) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" downshifts complement(2232379) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" promotor_-35 2233199..2233204 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233220..2233238 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2233230..2233423 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2233230 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" downshifts 2233381 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" CDS complement(2233454..2234737) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" gene complement(2233454..2234737) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" downshifts complement(2233457) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" promotor_-35 2233495..2233501 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233513..2233517 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2233513 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2234780..2234799) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234801) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" promotor_-35 complement(2234814..2234821) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2234893..2235477) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" gene complement(2234893..2235477) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" downshifts complement(2234895) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" S_feature complement(2235478..2235559) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2235552..2235571) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2235559) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" promotor_-35 complement(2235585..2235592) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2235636..2236415) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" gene complement(2235636..2236415) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" promotor_-10 complement(2236441..2236456) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2236452) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" promotor_-35 complement(2236468..2236477) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2236501..2236944) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" gene complement(2236501..2236944) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" downshifts complement(2236518) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" CDS complement(2237007..2237729) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" gene complement(2237007..2237729) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" downshifts complement(2237288) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" CDS complement(2237680..2238249) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" gene complement(2237680..2238249) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" promotor_-10 complement(2237998..2238016) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238014) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" promotor_-35 complement(2238031..2238037) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2238268..2239014 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2238309..2239799) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" gene complement(2238309..2239799) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" CDS complement(2239792..2240850) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" gene complement(2239792..2240850) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" promotor_-35 2240140..2240149 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2240160..2240950 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2240160 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" promotor_-10 2240162..2240181 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2240891..2240910) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2240914) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" promotor_-35 complement(2240922..2240929) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2240928..2240934 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2240948..2240967 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2240952..2241021 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2240952 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" promotor_-35 2241001..2241008 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2241023..2241115 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2241023..2241042 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2241023 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" CDS 2241116..2241364 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" gene 2241116..2241364 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" downshifts 2241348 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" CDS complement(2241404..2241976) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" gene complement(2241404..2241976) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" downshifts complement(2241424) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2241968..2242275) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" gene complement(2241968..2242275) /gene="fswB" /locus_tag="BSU_misc_RNA_78" S_feature complement(2241977..2242081) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2242274..2242293) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242290) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" promotor_-35 complement(2242307..2242313) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2242402..2242409 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2242420 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" promotor_-10 2242424..2242443 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2242473..2244050 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" gene 2242473..2244050 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" downshifts 2244032 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" CDS complement(2244093..2244860) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" gene complement(2244093..2244860) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" downshifts complement(2244108) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" S_feature 2244362..2244974 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2244887..2244906) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244900) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" promotor_-35 complement(2244921..2244924) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2244934 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" CDS complement(2244972..2246078) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" gene complement(2244972..2246078) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" downshifts complement(2244989) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" CDS complement(2246014..2246598) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" gene complement(2246014..2246598) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" promotor_-35 2246392..2246397 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2246408 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2246412..2246416 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2246549..2246554 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2246566 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" promotor_-10 2246570..2246588 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2246606 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2246647..2246666) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2246651..2246758 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2246655) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" promotor_-35 complement(2246679..2246686) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2246714 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" S_feature complement(2246743..2246801) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2246774) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" CDS complement(2246802..2248571) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" gene complement(2246802..2248571) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" downshifts complement(2246858) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" CDS complement(2248568..2249290) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" gene complement(2248568..2249290) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" S_feature complement(2249291..2249370) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2249371..2250546) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " gene complement(2249371..2250546) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" CDS complement(2250566..2252194) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" gene complement(2250566..2252194) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" CDS complement(2252191..2252730) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" gene complement(2252191..2252730) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" S_feature complement(2252731..2252824) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2252825..2253559) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" gene complement(2252825..2253559) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" promotor_-10 complement(2253568..2253587) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253591) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2253602..2253606) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2253651..2254187) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" gene complement(2253651..2254187) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" promotor_-10 complement(2253656..2253675) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253660) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2253690..2253697) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2254192..2254782) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" gene complement(2254192..2254782) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" CDS complement(2254770..2255918) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" gene complement(2254770..2255918) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" promotor_-10 complement(2255940..2255958) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255947) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2255973..2255978) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2256041..2256580) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" gene complement(2256041..2256580) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" downshifts complement(2256054) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2256589..2256606) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256604) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2256621..2256626) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2256635..2257228) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" gene complement(2256635..2257228) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" CDS complement(2257218..2257973) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" gene complement(2257218..2257973) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" promotor_-35 2257817..2257826 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2257839..2257858 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2257848 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2258019..2258038) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258034) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2258052..2258059) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2258199..2258206 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258217..2258236 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2258222 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" CDS 2258254..2258778 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" gene 2258254..2258778 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" CDS complement(2258792..2259166) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" gene complement(2258792..2259166) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" downshifts complement(2258808) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2259228..2259247) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259240) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2259259..2259266) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2259279..2259743) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" gene complement(2259279..2259743) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" promotor_-35 2259614..2259618 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2259632..2259636 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2259635 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2259776..2260972) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" gene complement(2259776..2260972) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" CDS complement(2260987..2261634) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" gene complement(2260987..2261634) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" CDS complement(2261645..2262730) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" gene complement(2261645..2262730) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" S_feature complement(2262731..2262859) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2262860..2263004) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" gene complement(2262860..2263004) /gene="fswA" /locus_tag="BSU_misc_RNA_36" promotor_-10 complement(2263021..2263040) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263031) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2263055..2263062) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2263124..2263468) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" gene complement(2263124..2263468) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" downshifts complement(2263139) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2263500..2263518) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263513) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" promotor_-35 2263527..2263532 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2263533..2263539) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2263547..2264469 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2263547 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" promotor_-10 2263548..2263566 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2263554..2263569) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263557) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" S_feature complement(2263559..2263625) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2263582..2263591) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2263620..2263628) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263625) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" promotor_-35 complement(2263642..2263650) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2263703..2264257) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" gene complement(2263703..2264257) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" downshifts complement(2263713) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2264283..2264302) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264301) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" S_feature complement(2264303..2264702) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2264314..2264320) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2264524..2264760 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" gene 2264524..2264760 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" CDS complement(2264703..2264909) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" gene complement(2264703..2264909) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" misc_feature complement(2264942..2264961) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2264964) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" CDS complement(2265018..2265272) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" gene complement(2265018..2265272) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo promotor_-35 2265152..2265161 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2265163..2265552) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" gene complement(2265163..2265552) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo S_feature 2265175..2266246 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2265175..2265194 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2265175 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" CDS complement(2265530..2265733) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" gene complement(2265530..2265733) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" CDS 2266142..2266258 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" gene 2266142..2266258 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo downshifts 2266209 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" promotor_-35 2266335..2266344 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2266357..2266376 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2266357 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" CDS 2266399..2266611 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" gene 2266399..2266611 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" downshifts 2266605 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" downshifts complement(2266747) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" CDS complement(2266747..2267178) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" gene complement(2266747..2267178) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" S_feature complement(2267179..2267265) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2267248..2267267) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267265) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" promotor_-35 complement(2267281..2267286) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2267315..2267324 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2267334..2267431 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2267334 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" promotor_-10 2267337..2267352 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2267432..2268304 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" gene 2267432..2268304 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" downshifts 2268211 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" downshifts 2268277 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" CDS complement(2268334..2269653) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" gene complement(2268334..2269653) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" downshifts complement(2268354) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" S_feature complement(2269654..2269718) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2269714..2269733) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269718) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2269748..2269755) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269759..2271240) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" gene complement(2269759..2271240) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" misc_feature complement(2270465..2270484) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2270469) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2271191..2271802) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" gene complement(2271191..2271802) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" CDS complement(2271810..2272160) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" gene complement(2271810..2272160) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" CDS complement(2272162..2273178) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" gene complement(2272162..2273178) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" promotor_-35 2272658..2272665 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272679..2272698 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2272701 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2273191..2273643) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" gene complement(2273191..2273643) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" CDS complement(2273656..2274081) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" gene complement(2273656..2274081) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" CDS complement(2274071..2274691) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" gene complement(2274071..2274691) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" promotor_-10 complement(2274722..2274733) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274732) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2274747..2274753) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274816..2275583) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" gene complement(2274816..2275583) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" downshifts complement(2274846) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" CDS complement(2275595..2276035) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" gene complement(2275595..2276035) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" CDS complement(2276032..2276385) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" gene complement(2276032..2276385) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" promotor_-10 complement(2276410..2276428) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276421) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" S_feature complement(2276423..2276480) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2276440..2276448) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276481..2277650) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" gene complement(2276481..2277650) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" promotor_-10 complement(2277679..2277690) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2277694) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" promotor_-35 complement(2277704..2277710) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2277796) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" CDS complement(2277805..2278620) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" gene complement(2277805..2278620) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" CDS complement(2278633..2279817) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" gene complement(2278633..2279817) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" promotor_-10 complement(2279866..2279885) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279884) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" S_feature complement(2279886..2279977) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2279901..2279908) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279978..2280868) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" gene complement(2279978..2280868) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" CDS complement(2280876..2281103) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" gene complement(2280876..2281103) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" promotor_-10 complement(2281006..2281025) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281017) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2281039..2281046) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2281096) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-10 complement(2281105..2281123) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2281133..2281151) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2281139..2281145) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2281146) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2281168..2281173) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2281228) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" CDS complement(2281228..2281677) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" gene complement(2281228..2281677) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" promotor_-10 complement(2281701..2281720) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2281711) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" S_feature complement(2281713..2281789) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2281736..2281740) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2281790..2282434) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" gene complement(2281790..2282434) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" promotor_-10 complement(2282465..2282483) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2282482) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" promotor_-35 complement(2282498..2282503) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2282535..2282750) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" gene complement(2282535..2282750) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" downshifts complement(2282615) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" CDS complement(2282850..2284169) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" gene complement(2282850..2284169) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" downshifts complement(2282857) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" CDS complement(2284187..2285593) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" gene complement(2284187..2285593) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" promotor_-10 complement(2285641..2285660) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285650) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2285652..2285733) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2285675..2285682) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2285734..2287161) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" gene complement(2285734..2287161) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" CDS complement(2287206..2288195) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" gene complement(2287206..2288195) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" S_feature complement(2288196..2288275) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2288257..2288276) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288275) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2288277..2288597) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2288291..2288298) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2288316..2288323 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2288336..2288355 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2288338 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" CDS 2288377..2288727 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" gene 2288377..2288727 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" S_feature complement(2288599..2288735) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2288642) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" CDS complement(2288736..2289899) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" gene complement(2288736..2289899) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" CDS complement(2289896..2290453) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" gene complement(2289896..2290453) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" promotor_no_box complement(2290383..2290483) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2290423) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" promotor_-35 2290467..2290472 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290488..2290506 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2290490..2290504) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2290494 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" S_feature 2290501..2290675 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2290506..2290509) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2290509) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" CDS 2290528..2290650 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" gene 2290528..2290650 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" promotor_-35 2290651..2290658 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290672..2290691 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2290677 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" CDS 2290713..2291633 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" gene 2290713..2291633 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" downshifts 2291622 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" CDS complement(2291665..2291889) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" gene complement(2291665..2291889) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" downshifts complement(2291722) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2291912..2291931) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291919) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" promotor_-35 complement(2291946..2291953) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2291968..2291975 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291990..2292009 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291997 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" CDS 2292051..2292968 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" gene 2292051..2292968 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" downshifts 2292943 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" CDS complement(2293008..2293247) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" gene complement(2293008..2293247) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" downshifts complement(2293019) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" CDS complement(2293260..2293583) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" gene complement(2293260..2293583) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" promotor_-10 complement(2293326..2293345) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293327) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2293359..2293366) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2293580..2294611) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" gene complement(2293580..2294611) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" promotor_-10 complement(2293607..2293626) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293614) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2293637..2293644) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294604..2294948) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" gene complement(2294604..2294948) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" CDS complement(2294958..2295428) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" gene complement(2294958..2295428) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" S_feature complement(2295429..2295505) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2295429 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(2295480..2295499) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2295505) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" S_feature complement(2295507..2295613) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2295514..2295521) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295614..2295952) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" gene complement(2295614..2295952) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" CDS complement(2295949..2297187) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" gene complement(2295949..2297187) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" misc_feature 2296111..2296112 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2296122 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2296177 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2297212..2297230) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2297221) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" promotor_-35 complement(2297247..2297252) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2297292..2297295 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2297310..2297329 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2297319 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" CDS 2297353..2297559 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" gene 2297353..2297559 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" promotor_-35 2298042..2298045 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2298060..2298079 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2298076 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" CDS 2298108..2299340 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" gene 2298108..2299340 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" CDS 2299187..2299549 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" gene 2299187..2299549 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" S_feature complement(2299366..2299545) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2299399) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" CDS complement(2299546..2299932) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" gene complement(2299546..2299932) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" CDS complement(2299936..2300895) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" gene complement(2299936..2300895) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" S_feature complement(2300896..2300966) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2300967..2302313) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" gene complement(2300967..2302313) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" S_feature complement(2302314..2302388) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2302389..2303168) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" gene complement(2302389..2303168) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" CDS complement(2303174..2304133) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" gene complement(2303174..2304133) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" promotor_-10 complement(2304155..2304174) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304174) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" promotor_-35 complement(2304189..2304196) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2304230..2304237 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2304251..2304537 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2304251 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" promotor_-10 2304253..2304272 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2304267..2304512 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" gene 2304267..2304512 /gene="pswI" /locus_tag="BSU_misc_RNA_91" CDS 2304538..2305374 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" gene 2304538..2305374 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" downshifts 2305372 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" CDS complement(2305415..2307058) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" gene complement(2305415..2307058) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" downshifts complement(2305427) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" promotor_-35 2307076..2307082 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2307089 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2307096..2307107 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2307114..2307133) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2307119) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" promotor_-35 2307165..2307172 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2307186..2307205 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2307188 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" CDS 2307230..2308246 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" gene 2307230..2308246 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" downshifts 2308233 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" promotor_-35 2308295..2308304 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308317..2308332 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2308321 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" CDS 2308356..2309117 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" gene 2308356..2309117 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" downshifts 2309025 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" downshifts 2309113 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" S_feature complement(2309145..2309345) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2309161..2309286) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" gene complement(2309161..2309286) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo downshifts complement(2309188) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" CDS complement(2309279..2309311) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" gene complement(2309279..2309311) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo promotor_-10 complement(2309339..2309358) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309345) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" promotor_-35 complement(2309371..2309378) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309393..2310316) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" gene complement(2309393..2310316) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" promotor_-10 complement(2310342..2310361) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310355) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" promotor_-35 complement(2310375..2310380) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2310454..2310461 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2310475..2310494 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2310477..2310542 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2310477 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" CDS 2310543..2312012 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" gene 2310543..2312012 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" downshifts 2311995 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" downshifts 2312063 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" CDS complement(2312137..2313546) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" gene complement(2312137..2313546) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" downshifts complement(2312154) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" downshifts complement(2312227) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" misc_feature complement(2313610..2313628) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2313612) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" CDS complement(2313656..2314900) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" gene complement(2313656..2314900) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" S_feature complement(2314901..2315175) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2314921..2314928 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314942..2314961 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2314942 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" CDS 2314973..2315260 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" gene 2314973..2315260 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" promotor_-10 complement(2315157..2315176) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2315177) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" promotor_-35 complement(2315192..2315195) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2315291..2316118 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " gene 2315291..2316118 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" downshifts 2315935 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" downshifts 2316111 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" S_feature complement(2316123..2317043) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2316166) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2316236..2316242 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2316256..2316274 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2316265 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" CDS 2316298..2317026 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" gene 2316298..2317026 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" CDS complement(2317067..2318182) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" gene complement(2317067..2318182) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" downshifts complement(2317088) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" CDS complement(2318200..2319723) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " gene complement(2318200..2319723) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" promotor_-10 complement(2319306..2319325) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319328) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" promotor_-35 complement(2319340..2319344) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2319716..2320138) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" gene complement(2319716..2320138) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" promotor_-35 2320167..2320174 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320188..2320207 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2320202..2320355 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2320202 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" downshifts 2320312 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" CDS complement(2320340..2320870) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" gene complement(2320340..2320870) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" S_feature 2320357..2320992 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2320887..2320898) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320894) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" promotor_-35 complement(2320913..2320919) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2320922..2321890) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" gene complement(2320922..2321890) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" downshifts complement(2320938) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" CDS complement(2321961..2322683) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" gene complement(2321961..2322683) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" downshifts complement(2321972) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" CDS complement(2322676..2323335) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" gene complement(2322676..2323335) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" S_feature complement(2323336..2323415) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2323416..2324183) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" gene complement(2323416..2324183) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" promotor_-10 complement(2324233..2324252) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324248) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" promotor_-35 complement(2324267..2324274) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2324451..2324888) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" gene complement(2324451..2324888) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" downshifts complement(2324460) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" promotor_-10 complement(2324912..2324931) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2324933) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" promotor_-35 complement(2324946..2324953) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2324986..2324992 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2325005 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" promotor_-10 2325007..2325025 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2325049..2325942 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" gene 2325049..2325942 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" promotor_-35 2325975..2325982 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325998..2326017 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326006 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" CDS 2326043..2327212 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" gene 2326043..2327212 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" downshifts 2327195 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" CDS 2327285..2328121 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" gene 2327285..2328121 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" downshifts 2328119 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" downshifts complement(2328183) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" CDS complement(2328183..2329457) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" gene complement(2328183..2329457) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" CDS complement(2329480..2330463) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" gene complement(2329480..2330463) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" CDS complement(2330477..2331469) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" gene complement(2330477..2331469) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" CDS complement(2331491..2332915) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" gene complement(2331491..2332915) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" CDS complement(2332936..2334027) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" gene complement(2332936..2334027) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" CDS complement(2334046..2335140) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" gene complement(2334046..2335140) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" CDS complement(2335152..2336051) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" gene complement(2335152..2336051) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" misc_feature complement(2336087..2336106) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2336092) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" S_feature complement(2336094..2336175) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2336176..2338254) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" gene complement(2336176..2338254) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" promotor_-10 complement(2338314..2338333) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338331) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" promotor_-35 2338341..2338348 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2338350..2338353) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338362..2338381 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338369 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" CDS 2338407..2338643 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" gene 2338407..2338643 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" downshifts 2338634 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" CDS complement(2338685..2339590) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" gene complement(2338685..2339590) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" downshifts complement(2338688) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" CDS complement(2339608..2341026) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" gene complement(2339608..2341026) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" misc_feature complement(2339903..2339922) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2339920) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2341041..2342159) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" gene complement(2341041..2342159) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" CDS complement(2342193..2343332) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" gene complement(2342193..2343332) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" CDS complement(2343360..2344223) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" gene complement(2343360..2344223) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" CDS complement(2344248..2345429) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" gene complement(2344248..2345429) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" downshifts complement(2345009) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" misc_feature complement(2345116..2345122) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2345119) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box complement(2345343..2345443) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2345383) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2345476..2345494) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345494) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" promotor_-35 complement(2345510..2345515) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2345556..2346287) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" gene complement(2345556..2346287) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" downshifts complement(2345563) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2346310..2346329) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346321) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2346344..2346347) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2346366..2346986) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" gene complement(2346366..2346986) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" CDS complement(2347001..2347294) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" gene complement(2347001..2347294) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" promotor_-10 complement(2347314..2347333) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347320) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2347348..2347355) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2347550..2347557 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2347571..2347590 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2347588..2347793 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2347588 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" CDS 2347602..2347754 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" gene 2347602..2347754 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" promotor_-35 2347762..2347769 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2347784..2347803 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2347795 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" CDS 2347827..2348945 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" gene 2347827..2348945 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" downshifts 2348930 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2348972..2349142) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2349015) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2349126..2349141) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349142) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" S_feature complement(2349144..2349272) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2349153..2349162) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2349271..2349290) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349294) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" promotor_-35 complement(2349304..2349312) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2349404) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" CDS complement(2349410..2350213) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" gene complement(2349410..2350213) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" promotor_-10 complement(2350256..2350274) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350262) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" S_feature complement(2350264..2350416) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2350285..2350293) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2350412..2350431) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350424) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" promotor_-35 complement(2350443..2350450) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2350489..2351769) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" gene complement(2350489..2351769) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" downshifts complement(2350504) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2351830..2351841) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351844) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" promotor_-35 complement(2351856..2351862) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2351944..2353674) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" gene complement(2351944..2353674) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" downshifts complement(2351959) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" CDS complement(2353711..2354160) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" gene complement(2353711..2354160) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" S_feature complement(2354161..2354246) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2354258..2355103) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" gene complement(2354258..2355103) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" downshifts complement(2354291) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" CDS complement(2355100..2357001) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" gene complement(2355100..2357001) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" promotor_-35 2356209..2356215 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356230..2356241 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2356238 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2357002..2357130) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2357125..2357144) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357130) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2357159..2357165) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2357176..2358066) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" gene complement(2357176..2358066) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" CDS complement(2358056..2358310) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" gene complement(2358056..2358310) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" CDS complement(2358307..2359653) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" gene complement(2358307..2359653) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" S_feature complement(2359654..2359790) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2359791..2360642) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" gene complement(2359791..2360642) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" CDS complement(2360654..2361049) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" gene complement(2360654..2361049) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" misc_feature complement(2361092..2361111) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2361111) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" S_feature complement(2361113..2361275) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2361313..2361720) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" gene complement(2361313..2361720) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" downshifts complement(2361320) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" CDS complement(2361741..2363093) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" gene complement(2361741..2363093) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" promotor_-10 complement(2362622..2362641) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2362629) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" promotor_-35 complement(2362656..2362662) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2363105..2363584) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " gene complement(2363105..2363584) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" promotor_-10 complement(2363643..2363662) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2363654) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2363676..2363683) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2363740..2364396) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" gene complement(2363740..2364396) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" downshifts complement(2363747) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" CDS complement(2364397..2365086) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" gene complement(2364397..2365086) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" CDS complement(2365079..2365699) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" gene complement(2365079..2365699) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" promotor_-10 complement(2365405..2365423) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365423) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" promotor_-35 complement(2365439..2365444) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2365713..2366912) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" gene complement(2365713..2366912) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" CDS complement(2366931..2367332) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" gene complement(2366931..2367332) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" CDS complement(2367339..2367545) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" gene complement(2367339..2367545) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" CDS complement(2367568..2368083) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" gene complement(2367568..2368083) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" CDS complement(2368077..2369000) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" gene complement(2368077..2369000) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" S_feature complement(2369001..2369075) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2369076..2369357) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" gene complement(2369076..2369357) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" promotor_-10 complement(2369377..2369395) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2369400) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" promotor_-35 complement(2369411..2369416) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2369502..2370059) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" gene complement(2369502..2370059) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" downshifts complement(2369514) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" CDS complement(2370084..2371145) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" gene complement(2370084..2371145) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" CDS complement(2371142..2371588) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" gene complement(2371142..2371588) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" promotor_-10 complement(2371637..2371656) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371653) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" promotor_-35 complement(2371669..2371676) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371675..2372211) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" gene complement(2371675..2372211) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" promotor_-10 complement(2372224..2372235) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2372233) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" promotor_-35 complement(2372249..2372255) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2372281..2372287 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2372300 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" promotor_-10 2372302..2372320 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2372357..2372360 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2372375..2372394 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2372386 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" CDS 2372438..2373394 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" gene 2372438..2373394 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" CDS 2373434..2373829 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" gene 2373434..2373829 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" promotor_no_box 2373712..2373812 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2373772 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2373815 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" CDS complement(2373826..2374701) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" gene complement(2373826..2374701) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" promotor_-10 complement(2374728..2374746) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374745) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" promotor_-35 complement(2374762..2374767) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2374827..2375255) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" gene complement(2374827..2375255) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" downshifts complement(2374854) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" promotor_-10 complement(2375290..2375309) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375298) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" promotor_-35 complement(2375325..2375329) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2375355..2376191) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" gene complement(2375355..2376191) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" promotor_-10 complement(2376215..2376234) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376226) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" S_feature complement(2376228..2376772) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2376248..2376255) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2376272..2376277 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2376291..2376310 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2376291 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" S_feature 2376302..2376381 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2376382..2376762 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" gene 2376382..2376762 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" downshifts 2376698 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" downshifts 2376742 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" CDS complement(2376797..2378263) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" gene complement(2376797..2378263) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" downshifts complement(2376817) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" CDS complement(2378256..2379602) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" gene complement(2378256..2379602) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" CDS complement(2379632..2380720) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" gene complement(2379632..2380720) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" misc_RNA complement(2380794..2380993) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" gene complement(2380794..2380993) /gene="swgA" /locus_tag="BSU_misc_RNA_37" downshifts complement(2380844) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" S_feature complement(2380994..2381064) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2380997..2381002 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2381018..2381036 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2381022 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" S_feature 2381032..2381161 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2381050..2381069) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2381064) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" promotor_-35 complement(2381083..2381090) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2381162..2382835 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" gene 2381162..2382835 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" CDS 2382856..2383650 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" gene 2382856..2383650 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" misc_feature 2383186..2383187 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2383192 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" promotor_-35 2383674..2383677 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2383693..2383712 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2383694..2383832 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2383694 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" CDS 2383833..2384006 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" gene 2383833..2384006 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" promotor_-35 2383991..2383995 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2384008..2384027 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2384008 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" CDS 2384040..2384375 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" gene 2384040..2384375 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" downshifts 2384352 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" downshifts 2384442 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" CDS complement(2384468..2385253) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" gene complement(2384468..2385253) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" downshifts complement(2384474) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2385306..2385323) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2385310) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" CDS complement(2385317..2385889) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" gene complement(2385317..2385889) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" CDS complement(2385873..2386634) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" gene complement(2385873..2386634) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" promotor_-10 complement(2386694..2386713) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2386712) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" promotor_-35 complement(2386727..2386734) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2386856..2386862 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2386863 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" promotor_-10 2386876..2386887 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2386906..2387232 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" gene 2386906..2387232 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" S_feature complement(2387049..2387273) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2387092) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" downshifts 2387214 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" CDS complement(2387274..2387453) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" gene complement(2387274..2387453) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" promotor_-10 complement(2387472..2387490) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387487) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2387505..2387511) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2387524..2387898) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" gene complement(2387524..2387898) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" CDS complement(2387899..2388282) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" gene complement(2387899..2388282) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" CDS complement(2388308..2388655) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" gene complement(2388308..2388655) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" CDS complement(2388639..2389070) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" gene complement(2388639..2389070) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" CDS complement(2389060..2389356) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" gene complement(2389060..2389356) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" CDS complement(2389370..2390341) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" gene complement(2389370..2390341) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" CDS complement(2390394..2391464) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" gene complement(2390394..2391464) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" promotor_-10 complement(2391482..2391501) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391498) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2391515..2391522) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2391647..2391875) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2391688) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" CDS complement(2391876..2392829) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" gene complement(2391876..2392829) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" promotor_-10 complement(2392853..2392872) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392874) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" promotor_-35 complement(2392886..2392892) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2392912..2392918 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2392933..2392951 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2392951 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" CDS 2392972..2394300 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" gene 2392972..2394300 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" S_feature 2394301..2395275 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2394353..2395189) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" gene complement(2394353..2395189) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" S_feature complement(2395190..2395374) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2395276..2395346 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene 2395276..2395346 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" CDS complement(2395413..2395793) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" gene complement(2395413..2395793) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" downshifts complement(2395419) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" promotor_-10 complement(2395822..2395840) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2395841) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" promotor_-35 complement(2395855..2395861) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2395880..2395885 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2395901..2395919 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2395910 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" promotor_-35 2395960..2395967 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2395982 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" promotor_-10 2395983..2396002 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2396025..2396270 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" gene 2396025..2396270 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" downshifts 2396167 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" downshifts 2396256 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" S_feature 2396301..2397056 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2396310..2396945) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" gene complement(2396310..2396945) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" downshifts complement(2396335) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2396967..2396986) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396984) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" promotor_-35 complement(2397000..2397007) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2397024..2397031 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2397046..2397065 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2397058 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" upshifts complement(2397078) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2397080..2397094) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2397102..2397106) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2397102..2397275 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" gene 2397102..2397275 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" downshifts 2397263 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" CDS complement(2397307..2397621) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" gene complement(2397307..2397621) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" S_feature 2397308..2398375 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2397321) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" CDS complement(2397624..2398685) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" gene complement(2397624..2398685) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" CDS complement(2398747..2399877) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" gene complement(2398747..2399877) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" promotor_-10 complement(2399885..2399903) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399917) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2399919..2399924) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2399960..2401876) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" gene complement(2399960..2401876) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" downshifts complement(2399987) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" promotor_-35 2400992..2400998 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2401011..2402040 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2401011 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" promotor_-10 2401014..2401032 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2401877..2401943) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2401937..2401956) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401943) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2401971..2401978) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2401993..2402958) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" gene complement(2401993..2402958) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" CDS complement(2402969..2403184) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" gene complement(2402969..2403184) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" S_feature complement(2403185..2403293) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2403294..2404817) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " gene complement(2403294..2404817) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" promotor_-10 complement(2404835..2404854) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404848) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2404869..2404876) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2404907..2405080) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" gene complement(2404907..2405080) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" downshifts complement(2404934) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2405096..2405107) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405108) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2405121..2405127) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2405147..2405710) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" gene complement(2405147..2405710) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" S_feature complement(2405711..2405794) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2405795..2405944) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" gene complement(2405795..2405944) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" downshifts complement(2405841) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" promotor_-10 complement(2405981..2406000) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405991) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2406016..2406019) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2406028..2407107) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" gene complement(2406028..2407107) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" CDS complement(2407104..2407574) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" gene complement(2407104..2407574) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" promotor_-35 2407519..2407527 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407541..2407549 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2407542..2407715 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2407543 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" promotor_-10 complement(2407610..2407629) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407622) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" promotor_-35 complement(2407641..2407648) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2407687..2407691 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407707..2407726 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2407717 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" CDS 2407754..2408107 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" gene 2407754..2408107 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" CDS 2408104..2408568 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" gene 2408104..2408568 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" downshifts 2408554 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" CDS complement(2408597..2409379) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" gene complement(2408597..2409379) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" downshifts complement(2408608) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" CDS complement(2409390..2410199) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" gene complement(2409390..2410199) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" CDS complement(2410220..2411104) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" gene complement(2410220..2411104) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" CDS complement(2411104..2412033) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" gene complement(2411104..2412033) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" CDS complement(2412102..2413004) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" gene complement(2412102..2413004) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" upshifts complement(2413059) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" promotor_-10 complement(2413067..2413083) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2413094..2413096) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2413158..2415308) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" gene complement(2413158..2415308) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" downshifts complement(2413168) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(2413902..2413920) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413910) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2413936..2413942) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2414597..2414616) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414614) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2414630..2414639) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2415358..2415377) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415363) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2415393..2415397) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2415422..2416714) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" gene complement(2415422..2416714) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" promotor_-10 complement(2416737..2416748) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416748) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2416762..2416768) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2416821..2417429) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" gene complement(2416821..2417429) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" downshifts complement(2416836) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2417481..2417500) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2417492) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" S_feature complement(2417494..2417562) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2417515..2417522) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2417553..2417571) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2417562) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" promotor_-35 complement(2417586..2417592) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2417608..2418090) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" gene complement(2417608..2418090) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" S_feature complement(2418091..2418383) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2418133..2418139 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418154..2418173 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418167 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" CDS 2418200..2418967 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" gene 2418200..2418967 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" promotor_-10 complement(2418381..2418399) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2418383) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" S_feature complement(2418385..2419321) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2418413..2418419) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2418968..2419398 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2419355 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" downshifts complement(2419366) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" CDS complement(2419383..2419811) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" gene complement(2419383..2419811) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" promotor_-35 2419807..2419811 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2419821..2419835 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2419830 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" promotor_-10 complement(2419834..2419853) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2419857) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" promotor_-35 complement(2419868..2419875) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2420026..2420031 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2420047..2420065 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2420059 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" CDS 2420088..2420387 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" gene 2420088..2420387 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" promotor_-35 2420400..2420407 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2420422..2420441 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2420433..2420509 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2420433 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" CDS 2420510..2421643 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" gene 2420510..2421643 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" downshifts 2421624 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" CDS complement(2421669..2422058) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" gene complement(2421669..2422058) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" downshifts complement(2421695) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2422089..2422100) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422093) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" promotor_-35 complement(2422114..2422120) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2422133..2422140 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422151..2422170 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2422152 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" CDS 2422191..2422772 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" gene 2422191..2422772 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" downshifts 2422770 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" S_feature 2422815..2423423 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2422815..2423252) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" gene complement(2422815..2423252) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" downshifts complement(2422819) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" S_feature complement(2423253..2423347) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2423343..2423362) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423347) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2423377..2423384) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2423390..2424271) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" gene complement(2423390..2424271) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" promotor_-35 2424267..2424272 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424288..2424306 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424304 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" misc_feature complement(2424309..2424328) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2424315) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" S_feature complement(2424317..2424644) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2424333..2424342 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2424349 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" promotor_-10 2424355..2424374 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2424387..2424641 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" gene 2424387..2424641 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" downshifts 2424628 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" CDS complement(2424668..2425561) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" gene complement(2424668..2425561) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" S_feature 2424673..2425474 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2424689) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" CDS complement(2425571..2426887) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" gene complement(2425571..2426887) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" promotor_-10 complement(2426923..2426942) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426934) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2426958..2426962) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2426991..2427000 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2427012 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" promotor_-10 2427014..2427033 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2427056..2427799 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" gene 2427056..2427799 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" downshifts 2427781 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" promotor_-35 2427803..2427810 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2427824..2427843 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2427826..2427921 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2427826 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" CDS 2427922..2428866 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" gene 2427922..2428866 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" downshifts 2428837 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" CDS complement(2428889..2430010) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" gene complement(2428889..2430010) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" downshifts complement(2428914) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" CDS complement(2430003..2430653) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" gene complement(2430003..2430653) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" S_feature complement(2430654..2430762) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2430750..2430769) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430762) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2430764..2430877) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2430785..2430789) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2430910..2431272) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" gene complement(2430910..2431272) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" downshifts complement(2430922) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" promotor_-35 2431268..2431272 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431280..2431294 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2431301 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2431309..2431328) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431311) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2431313..2431434) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2431340..2431347) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2431414 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2431423..2431442) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2431431..2431450 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431434) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2431436..2431575) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2431437..2431541 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2431437 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" promotor_-35 complement(2431456..2431462) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2431505..2431512 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431526..2431545 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2431543..2433692 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2431543 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" CDS complement(2431601..2432716) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" gene complement(2431601..2432716) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" downshifts complement(2431620) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" S_feature complement(2432717..2432914) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2432915..2434726) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" gene complement(2432915..2434726) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" promotor_-35 2434321..2434327 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2434337 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" promotor_-10 2434339..2434358 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2434366..2434662 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" gene 2434366..2434662 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" CDS complement(2434760..2435254) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" gene complement(2434760..2435254) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" promotor_-10 complement(2435227..2435245) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2435238) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2435255..2435368) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2435257..2435265) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2435263..2435268 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2435284..2435302 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2435299 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2435353..2435371) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2435368) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2435370..2435447) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2435387..2435392) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2435413..2435432) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2435447) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2435448..2435451) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2435508..2436320) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" gene complement(2435508..2436320) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" CDS complement(2436346..2436984) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" gene complement(2436346..2436984) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" S_feature complement(2436985..2437116) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2437110..2437129) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2437117..2439156) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" gene complement(2437117..2439156) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" upshifts complement(2437119) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2437144..2437151) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2437163) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" downshifts complement(2437229) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" CDS complement(2439149..2440036) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" gene complement(2439149..2440036) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" misc_RNA complement(2440119..2440293) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" gene complement(2440119..2440293) /gene="tboG" /locus_tag="BSU_misc_RNA_39" downshifts complement(2440153) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" promotor_-35 2440268..2440273 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2440289..2440307 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2440297..2440316) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2440299..2441711 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2440299 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" upshifts complement(2440309) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2440331..2440338) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2440333..2441100) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" gene complement(2440333..2441100) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" CDS complement(2441137..2441280) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" gene complement(2441137..2441280) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" S_feature complement(2441281..2441427) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2441428..2442333) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" gene complement(2441428..2442333) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" CDS complement(2442314..2442724) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" gene complement(2442314..2442724) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" promotor_-10 complement(2442762..2442781) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2442773) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" S_feature complement(2442775..2442842) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2442796..2442799) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2442843..2443214) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" gene complement(2442843..2443214) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" CDS complement(2443195..2443668) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" gene complement(2443195..2443668) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" CDS complement(2443669..2445804) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" gene complement(2443669..2445804) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" promotor_-35 2445648..2445653 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2445668 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2445669..2445687 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2445883..2446842) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" gene complement(2445883..2446842) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" downshifts complement(2445898) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" CDS complement(2446839..2448035) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" gene complement(2446839..2448035) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" promotor_-10 complement(2446906..2446925) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2446911) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2446939..2446946) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2446986..2447004) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2446998) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" promotor_-35 complement(2447019..2447025) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2447213) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" promotor_-10 complement(2447227..2447238) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2447253..2447259) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2448054..2448335) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" gene complement(2448054..2448335) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" CDS complement(2448392..2448811) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" gene complement(2448392..2448811) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" downshifts complement(2448406) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" CDS complement(2448836..2449831) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" gene complement(2448836..2449831) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" CDS complement(2449853..2451166) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" gene complement(2449853..2451166) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" promotor_-10 complement(2451202..2451217) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2451219) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" promotor_-35 complement(2451230..2451239) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2451297..2451743) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" gene complement(2451297..2451743) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" downshifts complement(2451310) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" downshifts complement(2451508) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" CDS complement(2451758..2451931) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" gene complement(2451758..2451931) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" misc_feature 2451867..2451871 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2451872 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2451992..2452011) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452007) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" promotor_-35 complement(2452025..2452032) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2452050..2452055 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2452070 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" promotor_-10 2452071..2452089 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2452104..2453027 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" gene 2452104..2453027 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" CDS complement(2453064..2454419) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" gene complement(2453064..2454419) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" downshifts complement(2453070) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" CDS complement(2454419..2455189) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" gene complement(2454419..2455189) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" CDS complement(2455212..2456147) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" gene complement(2455212..2456147) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" CDS complement(2456172..2457299) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" gene complement(2456172..2457299) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" misc_feature 2457216..2457219 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2457227 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2457300..2457477) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2457339..2457429 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 2457339..2457429 /gene="surC" /locus_tag="BSU_misc_RNA_79" CDS complement(2457499..2459334) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" gene complement(2457499..2459334) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" downshifts complement(2457522) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" CDS complement(2459358..2459921) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" gene complement(2459358..2459921) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" S_feature complement(2459922..2459992) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2459993..2461024) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" gene complement(2459993..2461024) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" promotor_-10 complement(2461065..2461084) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461078) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2461099..2461106) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461105..2462244) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" gene complement(2461105..2462244) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" promotor_-10 complement(2462117..2462128) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2462121) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" promotor_-35 complement(2462142..2462148) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2462297..2464135) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" gene complement(2462297..2464135) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" downshifts complement(2462319) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" promotor_-10 complement(2464170..2464189) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464187) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2464205..2464209) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2464269..2464607) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" gene complement(2464269..2464607) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" downshifts complement(2464275) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" CDS complement(2464624..2465829) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" gene complement(2464624..2465829) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" promotor_-10 complement(2465849..2465867) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465861) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2465883..2465888) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2465892..2466998) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" gene complement(2465892..2466998) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" promotor_-10 complement(2467026..2467037) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467033) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2467052..2467058) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2467097..2467100 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2467113 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" promotor_-10 2467116..2467135 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2467127..2467201 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2467202..2467468 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" gene 2467202..2467468 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" downshifts 2467457 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" CDS complement(2467483..2468526) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" gene complement(2467483..2468526) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" downshifts complement(2467528) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" promotor_-10 complement(2468555..2468574) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2468566..2468715) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" gene complement(2468566..2468715) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" upshifts complement(2468567) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" promotor_-35 complement(2468588..2468592) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2468590..2468929) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2468633) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" promotor_-35 2468702..2468708 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2468722..2468741 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2468723 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" CDS 2468756..2468890 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" gene 2468756..2468890 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" downshifts 2468884 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" CDS complement(2468930..2471260) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" gene complement(2468930..2471260) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" promotor_-10 complement(2468947..2468966) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468963) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2468980..2468989) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2471264..2471833) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" gene complement(2471264..2471833) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" promotor_-10 complement(2471860..2471879) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2471870) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" promotor_-35 complement(2471894..2471901) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2471900..2472517) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" gene complement(2471900..2472517) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" promotor_-35 2472538..2472543 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2472555 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" promotor_-10 2472559..2472577 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2472578..2472592) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472580) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" S_feature complement(2472582..2473429) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2472601..2472605) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2472601..2473422 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" gene 2472601..2473422 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" promotor_-10 complement(2473417..2473436) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2473423..2473503 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2473430) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2473450..2473457) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2473463 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" CDS complement(2473488..2474231) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" gene complement(2473488..2474231) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" downshifts complement(2473518) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" CDS complement(2474228..2474584) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" gene complement(2474228..2474584) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" CDS complement(2474602..2475162) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" gene complement(2474602..2475162) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" CDS complement(2475152..2475721) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" gene complement(2475152..2475721) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" CDS complement(2475733..2476023) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" gene complement(2475733..2476023) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" CDS complement(2476017..2476859) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" gene complement(2476017..2476859) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" downshifts 2476851 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" CDS complement(2476877..2477977) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" gene complement(2476877..2477977) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" CDS complement(2477981..2478499) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" gene complement(2477981..2478499) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" promotor_-10 complement(2478409..2478426) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478423) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2478442..2478445) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2478500..2479061) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2478533) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" promotor_-35 2478724..2478731 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2478742..2478842 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2478742..2478761 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478742 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" misc_RNA complement(2478792..2479050) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(2478792..2479050) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" CDS 2478843..2479001 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" gene 2478843..2479001 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" S_feature 2479002..2479248 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2479049..2479068) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479060) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2479084..2479088) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2479112..2479259) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2479149) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" downshifts 2479205 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" S_feature 2479250..2480303 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2479254..2479273) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479259) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" promotor_-35 complement(2479286..2479295) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479307..2480038) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" gene complement(2479307..2480038) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" promotor_-10 complement(2480057..2480076) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480073) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" S_feature complement(2480075..2480183) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2480090..2480096) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2480184..2480202) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480205) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" promotor_-35 complement(2480217..2480222) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2480290..2481042) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" gene complement(2480290..2481042) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" downshifts complement(2480293) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" promotor_-35 2480421..2480427 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2480441..2480459 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2480448 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2481052..2481071) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481071) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" promotor_-35 complement(2481085..2481093) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2481137..2481144 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2481159..2481178 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2481163..2481228 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2481163 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" CDS 2481229..2481855 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" gene 2481229..2481855 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" downshifts 2481823 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" CDS complement(2481874..2482767) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" gene complement(2481874..2482767) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" downshifts complement(2481899) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" promotor_-35 2482950..2482956 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2482968..2482987 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2482968 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" CDS 2483019..2483741 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" gene 2483019..2483741 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" CDS complement(2483774..2484184) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" gene complement(2483774..2484184) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" downshifts complement(2483799) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" promotor_-10 complement(2484204..2484222) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484206) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" promotor_-35 complement(2484238..2484243) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2484307..2484315 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2484328 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" promotor_-10 2484329..2484348 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2484380..2484850 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" gene 2484380..2484850 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo downshifts 2484570 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" downshifts 2484702 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" CDS complement(2484758..2486260) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" gene complement(2484758..2486260) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" downshifts complement(2484774) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(2486367..2486385) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486385) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" S_feature complement(2486387..2486688) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2486402..2486407) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2486709..2487128) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" gene complement(2486709..2487128) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" downshifts complement(2486733) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" CDS complement(2487140..>2487268) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2487140..>2487268) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2487264,2487271) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2487265..2487270 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2487266..2487652 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2487266..2487652 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2487619..2487637) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2487634..2488050 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" gene 2487634..2488050 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo misc_feature 2487639..2487653 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2487647) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2487658 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" downshifts 2488034 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" CDS 2488050..2488166 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" gene 2488050..2488166 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" S_feature 2488079..2489413 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2488197) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" CDS complement(2488275..2488439) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" gene complement(2488275..2488439) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" promotor_-10 complement(2488369..2488388) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488395) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" promotor_-35 complement(2488403..2488410) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2488573) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" CDS complement(2488984..2489400) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" gene complement(2488984..2489400) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" CDS complement(2489446..2490744) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" gene complement(2489446..2490744) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" CDS complement(2490731..2491426) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" gene complement(2490731..2491426) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" misc_feature complement(2491492..2491509) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2491501) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" promotor_-35 2491587..2491593 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2491600..2491618 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2491615 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2491694..2492911 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" gene 2491694..2492911 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" promotor_-35 2492153..2492160 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492175..2492194 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492191 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2492830..2493078 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" gene 2492830..2493078 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" S_feature complement(2493007..2494054) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2493423..2493980 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" gene 2493423..2493980 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" S_feature 2493981..2494103 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2494056..2494470) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2494099) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" CDS complement(2494471..2494995) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" gene complement(2494471..2494995) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" promotor_-35 2494843..2494850 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494861..2494880 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494875 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2494996..2495083) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2495078..2495097) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495083) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2495085..2495238) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2495112..2495119) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495239..2495715) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" gene complement(2495239..2495715) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" promotor_-10 complement(2495751..2495770) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495765) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2495767..2496297) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2495784..2495791) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2496298..2497083) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" gene complement(2496298..2497083) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" CDS complement(2497144..2497371) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" gene complement(2497144..2497371) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" downshifts complement(2497168) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" CDS complement(2497405..2498538) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" gene complement(2497405..2498538) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" misc_feature complement(2498240..2498255) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2498251) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2498539..2498872) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2498873..2499430) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" gene complement(2498873..2499430) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" S_feature complement(2499431..2499615) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2499616..2500098) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" gene complement(2499616..2500098) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" S_feature complement(2500099..2500207) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2500245..2500436) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" gene complement(2500245..2500436) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" downshifts complement(2500252) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" S_feature complement(2500437..2500526) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2500527..2500844) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" gene complement(2500527..2500844) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo promotor_-10 complement(2500633..2500652) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500649) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2500665..2500671) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2500886..2501101) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" gene complement(2500886..2501101) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo promotor_-10 complement(2500914..2500933) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500928) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2500948..2500955) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2501102..2501228) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2501229..2501789) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" gene complement(2501229..2501789) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" CDS complement(2501806..2501982) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" gene complement(2501806..2501982) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" promotor_-10 complement(2501816..2501835) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501827) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" S_feature complement(2501829..2502014) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2501848..2501857) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2502015..2502161) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" gene complement(2502015..2502161) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" CDS complement(2502331..2503152) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" gene complement(2502331..2503152) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" promotor_-35 2503160..2503167 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2503162..2503181) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2503179) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2503181..2505185) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2503183..2503202 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503191 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" CDS 2503269..2504471 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" gene 2503269..2504471 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" CDS 2504640..2505098 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" gene 2504640..2505098 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" downshifts complement(2505230) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" CDS complement(2505255..2506559) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" gene complement(2505255..2506559) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" S_feature complement(2506560..2506639) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2506625..2506644) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506639) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" promotor_-35 complement(2506659..2506666) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2506822..2506965) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" gene complement(2506822..2506965) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" CDS complement(2506983..2507948) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" gene complement(2506983..2507948) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" promotor_-35 2507986..2507989 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508004..2508023 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2508031 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" CDS 2508074..2508940 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" gene 2508074..2508940 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" S_feature 2508941..2509041 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2508999 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" CDS complement(2509063..2510100) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" gene complement(2509063..2510100) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" downshifts complement(2509075) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" S_feature complement(2510101..2510187) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2510188..2511123) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" gene complement(2510188..2511123) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" promotor_-10 complement(2511158..2511177) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511165) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" S_feature complement(2511167..2511250) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2511192..2511199) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2511231..2511250) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511250) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" promotor_-35 complement(2511264..2511271) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2511385) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" CDS complement(2511410..2511799) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" gene complement(2511410..2511799) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" promotor_-35 2512047..2512054 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512070..2512089 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512079 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" CDS 2512133..2513023 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" gene 2512133..2513023 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" promotor_-35 2512711..2512716 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512732..2512750 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512739 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2513181..2513498) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" gene complement(2513181..2513498) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" CDS complement(2513456..2514778) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" gene complement(2513456..2514778) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" CDS complement(2514943..2515275) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" gene complement(2514943..2515275) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" CDS complement(2515272..2516036) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" gene complement(2515272..2516036) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" CDS complement(2516049..2516522) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" gene complement(2516049..2516522) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" CDS complement(2516856..2517131) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" gene complement(2516856..2517131) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" misc_feature complement(2517143..2517162) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2517149) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2517217..2517402) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2517403..2518635) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" gene complement(2517403..2518635) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" CDS complement(2518685..2518843) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" gene complement(2518685..2518843) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo CDS complement(2518840..2519043) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" gene complement(2518840..2519043) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo promotor_-10 complement(2519004..2519022) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519021) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" CDS complement(2519028..2519177) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" gene complement(2519028..2519177) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo promotor_-35 complement(2519037..2519042) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2519261) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" CDS complement(2519276..2519839) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" gene complement(2519276..2519839) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" downshifts 2519757 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" promotor_-10 complement(2519869..2519888) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519877) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" promotor_-35 complement(2519903..2519910) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2520068..2520439) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" gene complement(2520068..2520439) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" S_feature complement(2520440..2520669) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2520651..2520670) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2520667) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" promotor_-35 complement(2520684..2520691) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2521235) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" CDS complement(2521249..2521752) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" gene complement(2521249..2521752) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" S_feature complement(2521753..2521977) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2521978..2522832) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" gene complement(2521978..2522832) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" S_feature complement(2522833..2522935) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2522916..2522935) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522933) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" promotor_-35 complement(2522950..2522953) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2523104..2523111 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523125..2523144 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523140 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" S_feature 2523145..2523210 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2523211..2524254 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" gene 2523211..2524254 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" downshifts 2524252 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" promotor_-35 2524539..2524546 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2524553 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" promotor_-10 2524560..2524579 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2524604..2525401 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" gene 2524604..2525401 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" promotor_-35 2525707..2525711 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2525725..2525744 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2525735 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" promotor_-10 complement(2525759..2525773) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525773) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2525782..2525786) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2525782..2526489 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" gene 2525782..2526489 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" downshifts 2526489 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" S_feature 2526534..2526707 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2526689..2526690 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2526706..2526725 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2526709..2527037 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2526709 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" CDS 2526813..2526974 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" gene 2526813..2526974 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo promotor_-35 2527003..2527012 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527025..2527044 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2527039..2527190 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2527039 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" CDS 2527065..2527142 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" gene 2527065..2527142 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" downshifts 2527147 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" S_feature 2527192..2527389 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2527381..2527652) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2527423) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" CDS complement(2527429..2527590) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" gene complement(2527429..2527590) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" CDS complement(2527653..2528408) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" gene complement(2527653..2528408) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" promotor_-10 complement(2528439..2528458) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528455) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" promotor_-35 complement(2528474..2528479) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2528540..2529070) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" gene complement(2528540..2529070) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" promotor_-10 complement(2529116..2529135) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2529139) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2529149..2529156) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2529205..2530185 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" gene 2529205..2530185 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" CDS complement(2530459..2531775) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" gene complement(2530459..2531775) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" S_feature complement(2531776..2531889) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2531890..2532759) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" gene complement(2531890..2532759) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" promotor_-10 complement(2532782..2532801) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532799) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" promotor_-35 complement(2532816..2532821) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2532866..2532867) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532874) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" promotor_-35 complement(2532904..2532905) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2532904..2534007 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" gene 2532904..2534007 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" misc_feature 2533897..2533916 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2533903 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(2534254) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" CDS complement(2534280..2535113) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" gene complement(2534280..2535113) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" misc_feature complement(2535143..2535162) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2535152) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" promotor_-35 2535318..2535322 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2535333..2535555 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2535333 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" promotor_-10 2535337..2535356 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2535556..2535819 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" gene 2535556..2535819 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" downshifts 2535807 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" CDS 2535956..2536771 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" gene 2535956..2536771 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" S_feature complement(2537106..2537178) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2537149) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" CDS complement(2537179..2537535) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" gene complement(2537179..2537535) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" CDS complement(2537588..2537947) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" gene complement(2537588..2537947) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" misc_feature complement(2538040..2538059) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2538050) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" CDS complement(2538219..2538320) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" gene complement(2538219..2538320) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" S_feature complement(2538360..2538462) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2538402) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" CDS complement(2538463..2538849) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" gene complement(2538463..2538849) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" misc_feature complement(2538891..2538907) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2538907) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" promotor_-35 2539040..2539046 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2539061..2539072 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2539061 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" CDS 2539098..2539343 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" gene 2539098..2539343 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" CDS 2539361..2539729 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" gene 2539361..2539729 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" CDS 2539748..2540884 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" gene 2539748..2540884 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" CDS 2540903..2541100 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" gene 2540903..2541100 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" CDS 2541116..2541415 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" gene 2541116..2541415 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" downshifts 2541406 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" CDS complement(2541678..2542100) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" gene complement(2541678..2542100) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" promotor_-35 2542098..2542101 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2542117..2542136 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2542132..2542282 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2542132 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" promotor_-10 complement(2542135..2542154) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542142) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" promotor_-35 complement(2542168..2542175) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2542251..2542270) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2542259) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" CDS 2542283..2542477 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" gene 2542283..2542477 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" promotor_-35 complement(2542285..2542292) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2542495..2542502 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2542518..2542537 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2542522 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" S_feature 2542523..2542607 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2542608..2543657 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" gene 2542608..2543657 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" promotor_-35 2543725..2543732 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2543747..2543766 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2543760 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" CDS 2543788..2544297 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" gene 2543788..2544297 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" downshifts 2544266 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" S_feature 2544311..2545416 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2544339..2546372) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" gene complement(2544339..2546372) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" downshifts complement(2544364) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" CDS complement(2546281..2546448) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" gene complement(2546281..2546448) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" S_feature complement(2546373..2546528) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2546529..2547356) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " gene complement(2546529..2547356) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" CDS complement(2547377..2548186) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" gene complement(2547377..2548186) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" CDS complement(2548203..2548691) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" gene complement(2548203..2548691) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" CDS complement(2548691..2549131) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" gene complement(2548691..2549131) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" downshifts 2549128 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" misc_feature complement(2549168..2549186) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2549172) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" CDS complement(2549321..2552128) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" gene complement(2549321..2552128) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" misc_feature complement(2552344..2552363) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2552350) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" CDS 2552675..2552815 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" gene 2552675..2552815 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" misc_feature 2552796..2552815 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2552806 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" CDS 2552854..2554242 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" gene 2552854..2554242 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" downshifts 2554231 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2554264..2554337) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2554306) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" CDS complement(2554338..2554970) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" gene complement(2554338..2554970) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" downshifts complement(2554394) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(2555024..2555043) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555035) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" promotor_-35 2555049..2555055 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2555058..2555065) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555069..2555088 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555074 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" CDS 2555123..2555950 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " gene 2555123..2555950 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" downshifts 2555946 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" promotor_-35 2556063..2556072 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2556085..2556100 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2556090 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" CDS 2556146..2556646 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" gene 2556146..2556646 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" CDS 2556646..2557503 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" gene 2556646..2557503 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" promotor_-10 complement(2557521..2557532) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557540) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2557547..2557553) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2557614..2559518 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" gene 2557614..2559518 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" promotor_-35 2559599..2559605 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559621..2559639 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559627 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" CDS 2559652..2559942 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" gene 2559652..2559942 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" S_feature 2559943..2560058 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2560040..2560047 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2560060..2560185 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2560060 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" promotor_-10 2560061..2560079 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2560079..2560179 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" gene 2560079..2560179 /gene="surF" /locus_tag="BSU_misc_RNA_82" downshifts 2560142 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" CDS complement(2560186..2563350) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" gene complement(2560186..2563350) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" downshifts complement(2560202) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" promotor_-35 2561336..2561345 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2561359..2561378 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2561380 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2563366..2563950) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" gene complement(2563366..2563950) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" CDS complement(2564173..2564715) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" gene complement(2564173..2564715) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" S_feature complement(2564716..2564801) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2564799..2564814) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564801) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" promotor_-35 complement(2564827..2564836) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2564870..2565086) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2564904..2565062) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" gene complement(2564904..2565062) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" downshifts complement(2564913) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(2565084..2565103) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565086) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" S_feature complement(2565088..2565218) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2565117..2565126) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565219..2565368) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" gene complement(2565219..2565368) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" downshifts 2565362 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" S_feature complement(2565369..2565459) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2565461..2565680) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2565504) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" downshifts 2565626 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" promotor_-10 complement(2565659..2565678) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565680) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" S_feature complement(2565682..2565757) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2565693..2565700) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565758..2566558) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" gene complement(2565758..2566558) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" S_feature complement(2566627..2566780) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2566670) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2566771..2566790) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2566780) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" promotor_-35 complement(2566805..2566811) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2566821..2567189) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" gene complement(2566821..2567189) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" S_feature complement(2567190..2567286) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2567272..2567291) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2567276..2567279 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2567292) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" promotor_-10 2567295..2567314 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2567297 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" S_feature 2567298..2567504 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2567307..2567311) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2567505..2570447 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" gene 2567505..2570447 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" CDS 2570466..2570948 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" gene 2570466..2570948 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" downshifts 2570928 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" CDS complement(2570984..2571214) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" gene complement(2570984..2571214) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" downshifts complement(2571004) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" S_feature complement(2571215..2571296) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2571297..2572436) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" gene complement(2571297..2572436) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" CDS complement(2572438..2573361) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" gene complement(2572438..2573361) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" downshifts complement(2573354) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" S_feature complement(2573362..2573425) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2573426..2574121) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" gene complement(2573426..2574121) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" promotor_-10 complement(2573861..2573880) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2573879) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2573893..2573902) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2574142..2574783) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" gene complement(2574142..2574783) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" promotor_-10 complement(2574350..2574369) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2574369) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2574386..2574389) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2574835..2574844 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2574841..2574860) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2574847) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-10 2574857..2574876 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2574866..2574930 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2574866 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" promotor_-35 complement(2574876..2574879) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2574911..2574918 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2574932 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" promotor_-10 2574934..2574951 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2574976..2575179 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" gene 2574976..2575179 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" downshifts 2575186 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" CDS complement(2575216..2575917) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" gene complement(2575216..2575917) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" downshifts complement(2575228) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" CDS complement(2575982..2577736) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" gene complement(2575982..2577736) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" misc_feature complement(2576010..2576029) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2576020) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-10 complement(2577051..2577066) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577054) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 complement(2577079..2577088) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2577282..2577300) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577296) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 2577315..2577322 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2577315..2577320) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577337..2577356 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2577342 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2577790..2578263) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" gene complement(2577790..2578263) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" downshifts complement(2577797) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" S_feature complement(2578264..2578396) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2578378..2578397) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2578396) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" S_feature complement(2578398..2578506) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2578411..2578418) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2578499..2578518) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2578506) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" CDS complement(2578514..2579149) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" gene complement(2578514..2579149) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" promotor_-35 complement(2578534..2578538) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2578644..2578649 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2578665..2578683 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2578672 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2579156..2580424) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" gene complement(2579156..2580424) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" CDS complement(2580443..2581372) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" gene complement(2580443..2581372) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" CDS complement(2581378..2582031) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " gene complement(2581378..2582031) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" S_feature complement(2582032..2582136) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2582118..2582137) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2582136) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2582153..2582157) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2582183..2583265) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" gene complement(2582183..2583265) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" downshifts complement(2582217) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" promotor_-10 complement(2583281..2583300) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583301) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2583315..2583318) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2583391) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" CDS complement(2583396..2583677) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" gene complement(2583396..2583677) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" downshifts complement(2583456) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" CDS complement(2583695..2584111) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" gene complement(2583695..2584111) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" promotor_-10 complement(2583943..2583961) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583962) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2583977..2583982) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2584119..2584385) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" gene complement(2584119..2584385) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" promotor_-35 2584273..2584281 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2584296..2584315 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2584304..2585493 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2584304 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" S_feature complement(2584386..2584446) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2584440..2584459) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584446) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" CDS complement(2584470..2587106) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" gene complement(2584470..2587106) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" promotor_-35 complement(2584473..2584480) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2586872..2586890) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2586888) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2586904..2586911) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2587107..2587185) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2587186..2587393) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2587186..2587393) /gene="tboA" /locus_tag="BSU_misc_RNA_40" promotor_-10 complement(2587401..2587420) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587416) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2587435..2587442) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2587437..2588498) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" gene complement(2587437..2588498) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" promotor_-35 2588407..2588412 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2588418..2588653 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2588419 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" promotor_-10 2588428..2588446 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2588515..2588526) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2588516) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" promotor_-35 complement(2588540..2588546) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2588654..2589382 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" gene 2588654..2589382 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" downshifts complement(2589110) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" CDS 2589404..2590225 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" gene 2589404..2590225 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" CDS 2590286..2590936 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" gene 2590286..2590936 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" CDS 2590953..2591609 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" gene 2590953..2591609 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" downshifts 2591608 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" CDS complement(2591644..2591775) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " gene complement(2591644..2591775) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" downshifts complement(2591662) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" CDS complement(2591797..2591988) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" gene complement(2591797..2591988) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" CDS complement(2592000..2592524) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" gene complement(2592000..2592524) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" upshifts complement(2592111) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-10 complement(2592115..2592126) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2592141..2592147) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2592495..2592506) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592501) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-35 complement(2592521..2592527) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592582..2594978) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" gene complement(2592582..2594978) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" downshifts complement(2592608) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" promotor_-35 2592828..2592834 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2592842 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" promotor_-10 2592849..2592860 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2592862..2593211 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2592963) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" CDS complement(2595003..2595623) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" gene complement(2595003..2595623) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" CDS complement(2595709..2596824) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" gene complement(2595709..2596824) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" downshifts complement(2595710) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" CDS complement(2596855..2597994) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" gene complement(2596855..2597994) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" promotor_-10 complement(2597561..2597580) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2597573) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2597594..2597601) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2598013..2598429) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" gene complement(2598013..2598429) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" S_feature complement(2598430..2598527) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2598512..2598531) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2598527) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2598547..2598550) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2598575..2598582 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2598596..2598615 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2598604 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" CDS 2598632..2599897 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" gene 2598632..2599897 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" downshifts 2599896 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" CDS complement(2599939..2600703) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" gene complement(2599939..2600703) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" downshifts complement(2599957) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2600787..2600987) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" gene complement(2600787..2600987) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" downshifts complement(2600805) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" upshifts 2600974 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2600975..2600984 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2600985..2601004) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600996) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2601017..2601024) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2601039..2602817) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" gene complement(2601039..2602817) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" CDS complement(2602831..2604105) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" gene complement(2602831..2604105) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" misc_RNA complement(2604195..2604427) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" gene complement(2604195..2604427) /gene="tboH" /locus_tag="BSU_misc_RNA_42" downshifts complement(2604225) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" promotor_-35 2604437..2604440 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2604451..2604470) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2604455..2604474 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2604457..2604741 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2604457 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" upshifts complement(2604470) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2604485..2604492) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2604487..2604657) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" gene complement(2604487..2604657) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" promotor_-10 complement(2604688..2604699) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2604705) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" promotor_-35 complement(2604714..2604720) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2604717..2604724 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2604738..2604756 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2604743 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" CDS 2604790..2606346 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" gene 2604790..2606346 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" downshifts 2606325 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" CDS complement(2606373..2606771) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" gene complement(2606373..2606771) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" downshifts complement(2606381) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" CDS complement(2606825..2609029) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" gene complement(2606825..2609029) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" promotor_-10 complement(2609058..2609077) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609065) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" S_feature complement(2609067..2609157) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2609092..2609099) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2609121 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" CDS complement(2609197..2609709) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" gene complement(2609197..2609709) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" downshifts complement(2609202) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" CDS complement(2609715..2612075) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" gene complement(2609715..2612075) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" promotor_-10 complement(2610179..2610198) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2610187) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2610212..2610221) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2612089..2612108) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612100) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" promotor_-35 complement(2612123..2612129) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612142..2612465) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" gene complement(2612142..2612465) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" promotor_-10 complement(2612486..2612504) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2612497) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2612519..2612525) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2612541..2613038) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" gene complement(2612541..2613038) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" S_feature complement(2613039..2613114) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2613108..2613127) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2613114) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" promotor_-35 complement(2613141..2613148) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2613196..2615409) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" gene complement(2613196..2615409) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" downshifts complement(2613201) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" promotor_-35 2614968..2614973 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2614987..2615006 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614995 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2615448..2615744) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" gene complement(2615448..2615744) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" downshifts 2615655 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" S_feature complement(2615745..2615823) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2615785..2615790 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2615807..2615825 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2615809..2615828) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2615809 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" upshifts complement(2615823) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" S_feature complement(2615825..2616743) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2615843..2615846) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2615860..2617416 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" gene 2615860..2617416 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" promotor_-10 complement(2616729..2616747) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2616743) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" promotor_-35 complement(2616759..2616767) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2617417..2618181 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2617420..2618076) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" gene complement(2617420..2618076) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" promotor_-10 complement(2618095..2618106) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618107) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" promotor_-35 complement(2618120..2618126) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2618159..2618164 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2618180..2618198 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2618183 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" CDS 2618211..2618663 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" gene 2618211..2618663 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" downshifts 2618647 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" downshifts complement(2618702) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" CDS complement(2618720..2618986) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" gene complement(2618720..2618986) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" CDS complement(2619023..2620168) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" gene complement(2619023..2620168) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" upshifts complement(2619075) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" misc_feature complement(2619078) /Source="Nicolas_upshift_promotors" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2619119) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" promotor_-10 complement(2619121..2619140) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2619155..2619160) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2620195..2621223) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" gene complement(2620195..2621223) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" CDS complement(2621253..2621453) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" gene complement(2621253..2621453) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" CDS complement(2621446..2622450) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" gene complement(2621446..2622450) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" CDS complement(2622461..2623066) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" gene complement(2622461..2623066) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" promotor_-10 complement(2623085..2623104) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623101) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" S_feature complement(2623103..2623204) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2623115..2623121) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623205..2623717) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" gene complement(2623205..2623717) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" promotor_-10 complement(2623746..2623757) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2623761) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" CDS complement(2623765..2625072) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" gene complement(2623765..2625072) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" promotor_-35 complement(2623772..2623778) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2625026) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" promotor_-10 complement(2625096..2625114) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2625111) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" promotor_-35 complement(2625129..2625135) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2625143..2626168) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" gene complement(2625143..2626168) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" promotor_-10 complement(2626205..2626224) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2626225) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" promotor_-35 complement(2626239..2626246) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2626294..2626301 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626315..2626334 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626323 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-35 2626355..2626360 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2626369 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-10 2626376..2626394 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2626406..2627053 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" gene 2626406..2627053 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" S_feature complement(2626728..2627061) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2627032 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" S_feature complement(2627063..2627260) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2627099..2627221) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" gene complement(2627099..2627221) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" downshifts complement(2627106) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" upshifts complement(2627269) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" promotor_-10 complement(2627270..2627287) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2627294..2627301) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2627306..2627596 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" gene 2627306..2627596 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" misc_feature 2627317..2627336 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2627317..2627464 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2627317 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" CDS 2627603..2627743 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" gene 2627603..2627743 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" downshifts 2627732 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2627792..2627798 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2627806..2627906 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2627813..2627831 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2627814 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" upshifts 2627866 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" CDS 2627907..2629361 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" gene 2627907..2629361 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" downshifts 2629362 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" CDS complement(2629402..2630124) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" gene complement(2629402..2630124) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" S_feature 2629407..2629828 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2629418) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" promotor_-10 complement(2630147..2630166) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630164) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" promotor_-35 complement(2630180..2630187) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630227..2630823) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" gene complement(2630227..2630823) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" downshifts complement(2630242) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" promotor_-10 complement(2630866..2630877) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630868) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" S_feature complement(2630870..2630934) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2630892..2630898) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630971..2632134) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" gene complement(2630971..2632134) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" downshifts complement(2630979) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" S_feature complement(2632135..2632210) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2632186..2632204) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632210) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2632220..2632225) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2632251..2633357) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" gene complement(2632251..2633357) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" promotor_-10 complement(2632933..2632951) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632958) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2632967..2632972) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2633269 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2633270..2633273 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2633344..2634213) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" gene complement(2633344..2634213) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" downshifts 2633438 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" CDS complement(2634167..2635762) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" gene complement(2634167..2635762) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" promotor_-10 complement(2635790..2635809) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2635790..2635797 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2635811 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" promotor_-10 2635813..2635832 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635814) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2635824..2635831) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2635865..2637052 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" gene 2635865..2637052 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" promotor_-10 complement(2635866..2635885) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635884) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2635900..2635909) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2636767..2636772 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2636781 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" promotor_-10 2636783..2636802 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2637012..2637554 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" gene 2637012..2637554 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" downshifts 2637537 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" CDS complement(2637579..2638436) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" gene complement(2637579..2638436) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" S_feature 2637582..2638291 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2637599) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" CDS complement(2638453..2638896) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" gene complement(2638453..2638896) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" CDS complement(2638957..2640243) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" gene complement(2638957..2640243) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" CDS complement(2640277..2640855) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" gene complement(2640277..2640855) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" S_feature complement(2640856..2640921) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2640906..2640925) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640921) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" S_feature complement(2640923..2641140) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2640933..2641055 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" gene 2640933..2641055 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" promotor_-35 complement(2640939..2640946) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2641176..2641460) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" gene complement(2641176..2641460) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" downshifts complement(2641185) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" CDS complement(2641473..2641811) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" gene complement(2641473..2641811) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" CDS complement(2641814..2642122) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" gene complement(2641814..2642122) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" misc_RNA complement(2642136..2642211) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" gene complement(2642136..2642211) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" promotor_-10 complement(2642223..2642242) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642243) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" promotor_-35 complement(2642256..2642263) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642269..2643135) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" gene complement(2642269..2643135) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" CDS complement(2643128..2643922) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" gene complement(2643128..2643922) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" downshifts 2643925 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" promotor_no_box 2643931..2644031 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2643946..2643964) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2643957) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" promotor_-35 complement(2643980..2643985) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2643991 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2644034 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" downshifts complement(2644069) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" CDS complement(2644072..2644878) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" gene complement(2644072..2644878) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" CDS complement(2644880..2645560) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" gene complement(2644880..2645560) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" CDS complement(2645613..2646131) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" gene complement(2645613..2646131) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" CDS complement(2646128..2647000) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" gene complement(2646128..2647000) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" CDS complement(2647031..2648044) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" gene complement(2647031..2648044) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" upshifts complement(2648085) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" misc_feature complement(2648097..2648115) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2648136..2648831) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" gene complement(2648136..2648831) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" CDS complement(2648868..2649437) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" gene complement(2648868..2649437) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" promotor_-10 complement(2649289..2649304) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649298) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2649317..2649326) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2649476..2649495) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649492) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2649509..2649515) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2649588) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" CDS complement(2649590..2650588) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" gene complement(2649590..2650588) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" promotor_-10 complement(2650635..2650654) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650643) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2650666..2650673) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2650711) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" CDS complement(2650722..2651468) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" gene complement(2650722..2651468) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" promotor_-10 complement(2651496..2651515) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2651503) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2651530..2651537) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2651608..2652900) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" gene complement(2651608..2652900) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" downshifts complement(2651613) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" S_feature complement(2652901..2652959) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2652960..2655602) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" gene complement(2652960..2655602) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" S_feature complement(2655603..2655661) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2655662..2655884) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2655662..2655884) /gene="tboV" /locus_tag="BSU_misc_RNA_44" downshifts complement(2655705) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" promotor_-10 complement(2655913..2655932) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655925) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" S_feature complement(2655927..2656035) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2655947..2655952) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2655989..2655998 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2656011..2656030 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2656012 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" promotor_-10 complement(2656028..2656042) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656035) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" promotor_-35 complement(2656050..2656054) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2656050..2656241 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" gene 2656050..2656241 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" CDS complement(2656260..2657285) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" gene complement(2656260..2657285) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" downshifts complement(2656290) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" CDS complement(2657318..2659045) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" gene complement(2657318..2659045) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" promotor_-35 2658647..2658650 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2658666..2658685 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658672 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2659041..2659045 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2659054..2659068 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2659068 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2659083..2659101) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2659099) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" promotor_-35 complement(2659117..2659122) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2659176..2660468) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" gene complement(2659176..2660468) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" downshifts complement(2659193) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" CDS complement(2660498..2661472) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" gene complement(2660498..2661472) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" CDS complement(2661469..2662257) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" gene complement(2661469..2662257) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" CDS complement(2662247..2663191) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" gene complement(2662247..2663191) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" CDS complement(2663224..2664054) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" gene complement(2663224..2664054) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" CDS complement(2664062..2665429) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" gene complement(2664062..2665429) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" misc_feature complement(2665493..2665512) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2665499) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2665501..2665590) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2665550..2665569 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2665558 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2665587..2665606) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2665590) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2665592..2666008) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2665617..2665625) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2665659..2666156 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" gene 2665659..2666156 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" promotor_-10 complement(2665992..2666010) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666008) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" S_feature complement(2666010..2666140) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2666026..2666032) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2666120..2666131) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2666140) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" promotor_-35 complement(2666146..2666152) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2666178..2666765) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" gene complement(2666178..2666765) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" downshifts complement(2666206) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" CDS complement(2666762..2669086) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" gene complement(2666762..2669086) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" S_feature complement(2669087..2669198) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2669183..2669202) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669198) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" promotor_-35 complement(2669216..2669223) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669267..2670925) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" gene complement(2669267..2670925) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" downshifts complement(2669286) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2670969..2670987) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670980) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" promotor_-35 complement(2671003..2671008) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2671077..2672339) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" gene complement(2671077..2672339) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" downshifts complement(2671087) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2672340..2672429) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2672417..2672436) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672429) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" S_feature complement(2672431..2672562) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2672448..2672455) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2672607) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" CDS complement(2672611..2673885) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" gene complement(2672611..2673885) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" S_feature complement(2673886..2674075) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2674062..2674081) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674075) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" promotor_-35 complement(2674096..2674100) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2674113..2675117) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" gene complement(2674113..2675117) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" promotor_-10 complement(2675142..2675161) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2675160) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2675173..2675180) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2675236..2675835) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" gene complement(2675236..2675835) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" downshifts complement(2675257) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" CDS complement(2675848..2677266) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" gene complement(2675848..2677266) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" promotor_-35 2677155..2677159 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2677174..2677178 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677174 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2677316..2678413) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" gene complement(2677316..2678413) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" CDS complement(2678434..2679990) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" gene complement(2678434..2679990) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" promotor_-35 2678830..2678833 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2678846..2681287 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2678846 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" promotor_-10 2678848..2678867 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2679977..2681005) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" gene complement(2679977..2681005) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" CDS complement(2681029..2681547) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" gene complement(2681029..2681547) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" promotor_-35 2681268..2681271 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2681287..2681291 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2681289 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2681544..2683268) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" gene complement(2681544..2683268) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" S_feature complement(2683269..2683389) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2683390..2683636) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2683390..2683636) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" downshifts complement(2683433) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" S_feature complement(2683637..2683763) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2683745..2683764) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2683763) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" S_feature complement(2683765..2683895) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2683779..2683786) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2683890..2683909) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2683899) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2683923..2683926) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2684021..2684030 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684044..2684063 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2684046 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" CDS 2684084..2684419 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" gene 2684084..2684419 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" downshifts 2684413 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" promotor_-35 2684500..2684507 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684521..2684540 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2684523..2684587 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2684523 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" CDS 2684588..2685043 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" gene 2684588..2685043 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" promotor_-35 2685151..2685157 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2685171..2685189 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685178 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" CDS 2685227..2686048 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" gene 2685227..2686048 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" downshifts 2686041 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" downshifts 2686105 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" tRNA complement(2686112..2686185) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2686112..2686185) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" downshifts complement(2686146) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" promotor_-10 complement(2686222..2686241) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686225) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" promotor_-35 complement(2686255..2686262) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686316..2686825) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" gene complement(2686316..2686825) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" downshifts complement(2686333) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" CDS complement(2686841..2687437) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" gene complement(2686841..2687437) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" CDS complement(2687450..2688187) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" gene complement(2687450..2688187) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" promotor_-10 complement(2688269..2688288) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688285) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" CDS complement(2688298..2689398) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" gene complement(2688298..2689398) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" promotor_-35 complement(2688303..2688308) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2688315) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" promotor_-10 complement(2689421..2689439) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689437) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" promotor_-35 complement(2689454..2689459) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2689513..2690331) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" gene complement(2689513..2690331) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" downshifts complement(2689525) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" CDS complement(2690339..2690779) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" gene complement(2690339..2690779) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" promotor_-10 complement(2690822..2690841) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690831) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" S_feature complement(2690833..2690975) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2690857..2690861) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2691020) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" CDS complement(2691023..2691247) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" gene complement(2691023..2691247) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" upshifts 2691296 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2691298..2691316 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2691305..2691324) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691325) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" promotor_-35 complement(2691338..2691347) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2691363..2691806) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" gene complement(2691363..2691806) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" CDS complement(2691867..2692628) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" gene complement(2691867..2692628) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" downshifts complement(2691875) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" CDS complement(2692631..2694391) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" gene complement(2692631..2694391) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" CDS complement(2694425..2695033) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" gene complement(2694425..2695033) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" promotor_-35 2694803..2694810 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2694823..2694842 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2694825 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2695034..2695129) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2695119..2695138) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2695129) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" S_feature complement(2695131..2695752) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2695153..2695160) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2695268..2695272 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2695282..2695382 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2695289..2695308 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2695298 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" CDS 2695326..2695772 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" gene 2695326..2695772 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" upshifts 2695342 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" downshifts 2695760 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" downshifts complement(2695798) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" CDS complement(2695816..2697042) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" CDS complement(2695816..2696307) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" gene complement(2695816..2697042) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" gene complement(2695816..2696307) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" downshifts complement(2697156) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" misc_RNA complement(2697168..2697347) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" gene complement(2697168..2697347) /gene="kswC" /locus_tag="BSU_misc_RNA_46" downshifts complement(2697200) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2697372..2697391) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2697379) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" promotor_-35 complement(2697404..2697411) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2697412..2699184) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" gene complement(2697412..2699184) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" promotor_-10 complement(2699211..2699230) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2699225) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" promotor_-35 complement(2699244..2699251) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2699314) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" CDS complement(2699320..2699634) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" gene complement(2699320..2699634) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" promotor_-10 complement(2699660..2699679) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699674) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" S_feature complement(2699676..2699885) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2699695..2699697) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2699779..2699889) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" gene complement(2699779..2699889) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo promotor_-10 complement(2699875..2699893) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2699885) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" promotor_-35 complement(2699908..2699914) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2699957..2701444) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" gene complement(2699957..2701444) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" S_feature complement(2701445..2701557) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2701538..2701557) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2701557) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" promotor_-35 complement(2701572..2701579) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2701661..2702638) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" gene complement(2701661..2702638) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" downshifts complement(2701669) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" CDS complement(2702674..2703447) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" gene complement(2702674..2703447) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" CDS complement(2703462..2704238) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" gene complement(2703462..2704238) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" downshifts 2703527 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" CDS complement(2704253..2704837) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" gene complement(2704253..2704837) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" promotor_-10 complement(2704879..2704898) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704879) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" promotor_-35 complement(2704911..2704918) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2704942..2706624) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" gene complement(2704942..2706624) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" misc_feature complement(2706653..2706672) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2706661) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" downshifts complement(2706749) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" CDS complement(2706813..2707217) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" gene complement(2706813..2707217) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" downshifts complement(2706815) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" CDS complement(2707232..2709589) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" gene complement(2707232..2709589) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" CDS complement(2709610..2711322) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" gene complement(2709610..2711322) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" S_feature complement(2711323..2711395) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2711396..2711929) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" gene complement(2711396..2711929) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" CDS complement(2711936..2712193) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" gene complement(2711936..2712193) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" promotor_-10 complement(2712220..2712239) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712236) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" promotor_-35 complement(2712251..2712258) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2712276..2712295 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2712283 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" CDS 2712327..2713268 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" gene 2712327..2713268 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" promotor_-10 complement(2713000..2713019) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713015) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2713033..2713040) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2713251 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" downshifts complement(2713283) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" CDS complement(2713304..2715718) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" gene complement(2713304..2715718) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" downshifts complement(2713327) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" CDS complement(2715734..2716768) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" gene complement(2715734..2716768) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" S_feature complement(2716769..2717089) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2716850..2717056 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" gene 2716850..2717056 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" S_feature 2717079..2717343 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2717079 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" promotor_-10 complement(2717084..2717103) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2717086..2717100 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2717089) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" promotor_-35 complement(2717118..2717121) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717123..2717869) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" gene complement(2717123..2717869) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" promotor_-10 complement(2717896..2717915) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2717902..2717908 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2717909) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" promotor_-10 2717922..2717933 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2717929..2717935) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2717936 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" CDS 2717988..2718203 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" gene 2717988..2718203 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" S_feature complement(2718185..2719597) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2718214..2718221 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718237..2718256 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718245 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" CDS 2718272..2719378 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" gene 2718272..2719378 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" promotor_-35 2719414..2719417 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719433..2719452 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719437 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" CDS 2719481..2720893 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" gene 2719481..2720893 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" promotor_-10 complement(2719583..2719602) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719597) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" promotor_-35 complement(2719615..2719624) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2720890..2722224 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" gene 2720890..2722224 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" downshifts 2722222 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" downshifts complement(2722261) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" CDS complement(2722263..2722505) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" gene complement(2722263..2722505) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" S_feature complement(2722506..2722677) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2722565..2722735) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" gene complement(2722565..2722735) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" CDS complement(2722678..2724474) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" gene complement(2722678..2724474) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" promotor_-10 complement(2722780..2722798) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722798) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2722810..2722818) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2724471 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" promotor_-10 complement(2724499..2724518) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724509) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2724533..2724539) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2724569..2724625) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2724593) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" CDS complement(2724626..2726128) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" gene complement(2724626..2726128) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" downshifts complement(2725999) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" promotor_no_box complement(2726103..2726203) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2726143) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" CDS complement(2726147..2726992) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" gene complement(2726147..2726992) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" CDS complement(2726993..2727934) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" gene complement(2726993..2727934) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" CDS complement(2727970..2729271) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" gene complement(2727970..2729271) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" CDS complement(2729302..2730486) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" gene complement(2729302..2730486) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" CDS complement(2730483..2731301) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" gene complement(2730483..2731301) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" CDS complement(2731279..2731968) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" gene complement(2731279..2731968) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" CDS complement(2731985..2733667) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" gene complement(2731985..2733667) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" CDS complement(2733681..2735171) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" gene complement(2733681..2735171) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" promotor_-10 complement(2735264..2735283) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2735271) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" S_feature complement(2735273..2735348) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2735298..2735305) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2735349..2736320) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" gene complement(2735349..2736320) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" S_feature complement(2736321..2736449) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2736434..2736453) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2736449) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" promotor_-35 complement(2736468..2736471) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2736517..2737602) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" gene complement(2736517..2737602) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" downshifts complement(2736531) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2737628..2737647) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2737651) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" promotor_-35 complement(2737662..2737669) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2737720..2737729 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2737735 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" promotor_-10 2737741..2737756 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2737786..2738178 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" gene 2737786..2738178 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" downshifts 2738149 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" S_feature 2738194..2738500 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2738194..2738463) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" gene complement(2738194..2738463) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" downshifts complement(2738210) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" downshifts complement(2738379) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" downshifts 2738457 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" CDS complement(2738520..2738879) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" gene complement(2738520..2738879) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" downshifts complement(2738533) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" CDS complement(2738911..2739111) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" gene complement(2738911..2739111) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" CDS complement(2739124..2739645) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" gene complement(2739124..2739645) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" misc_RNA complement(2739707..2739846) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" gene complement(2739707..2739846) /locus_tag="BSU_misc_RNA_47" promotor_-10 complement(2739843..2739862) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739853) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" S_feature complement(2739855..2739919) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2739876..2739883) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2739901..2739920) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739919) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" promotor_-35 complement(2739936..2739940) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2740038..2740045 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2740059..2740077 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2740059 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" CDS 2740091..2740756 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" gene 2740091..2740756 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" downshifts 2740734 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" CDS complement(2740788..2741483) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" gene complement(2740788..2741483) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" downshifts complement(2740810) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" downshifts complement(2740854) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" CDS complement(2741505..2741945) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" gene complement(2741505..2741945) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" promotor_-10 complement(2741967..2741986) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741986) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" promotor_-35 complement(2742002..2742005) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2742079..2742804) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" gene complement(2742079..2742804) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" downshifts complement(2742108) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" CDS complement(2742782..2744563) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" gene complement(2742782..2744563) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" promotor_-35 2744647..2744650 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2744659..2744678) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2744664) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2744665..2744684 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744672 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" CDS 2744730..2745512 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" gene 2744730..2745512 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" downshifts 2745496 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" downshifts complement(2745546) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" CDS complement(2745553..2747484) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" gene complement(2745553..2747484) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" misc_RNA complement(2747528..2747775) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2747528..2747775) /gene="tboT" /locus_tag="BSU_misc_RNA_48" promotor_-10 complement(2747531..2747540) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747531) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" promotor_-35 complement(2747559) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2747586) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" promotor_-10 complement(2747786..2747805) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747799) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" S_feature complement(2747801..2747881) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2747821..2747825) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2747882..2748727) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" gene complement(2747882..2748727) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" promotor_-10 complement(2748747..2748765) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748753) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2748781..2748786) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2748806..2749447) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" gene complement(2748806..2749447) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" CDS complement(2749481..2750416) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" gene complement(2749481..2750416) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" CDS complement(2750444..2751862) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" gene complement(2750444..2751862) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" promotor_-10 complement(2751891..2751910) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751899) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2751925..2751928) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2751977..2752435) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" gene complement(2751977..2752435) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" downshifts complement(2751996) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2752436..2752583) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2752574..2752593) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2752583) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" S_feature complement(2752585..2752663) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2752608..2752611) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2752708) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" CDS complement(2752709..2753089) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" gene complement(2752709..2753089) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" S_feature complement(2753090..2753244) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2753224..2753243) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753231 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2753232..2753251 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2753244) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2753258..2753264) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2753322..2753333) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2753328..2754350) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" gene complement(2753328..2754350) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" upshifts complement(2753329) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" promotor_-35 complement(2753348..2753354) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2754394..2754413) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2754425) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" promotor_-35 complement(2754426..2754433) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2754556..2754936) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" gene complement(2754556..2754936) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" downshifts complement(2754580) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" S_feature complement(2754937..2755067) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2754992..2754996 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2755012..2755031 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2755013..2755119 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2755013 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" promotor_-10 complement(2755057..2755076) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755067) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" promotor_-35 complement(2755091..2755098) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2755120..2756310 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" gene 2755120..2756310 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" promotor_-10 complement(2755942..2755960) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755958) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2755976..2755981) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2756334..2757176 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" gene 2756334..2757176 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" promotor_-35 2756949..2756954 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2756970..2756988 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2756971 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2757169 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" downshifts complement(2757209) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" CDS complement(2757218..2757811) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" gene complement(2757218..2757811) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" CDS complement(2757827..2758459) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" gene complement(2757827..2758459) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" S_feature complement(2758460..2758624) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2758625..2759455) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" gene complement(2758625..2759455) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" CDS complement(2759478..2762120) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" gene complement(2759478..2762120) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" promotor_-10 complement(2762175..2762194) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762184) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" promotor_-35 complement(2762208..2762215) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2762244..2762363) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2762287) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" CDS complement(2762364..2764103) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" gene complement(2762364..2764103) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" CDS complement(2764096..2764818) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" gene complement(2764096..2764818) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" promotor_-10 complement(2764886..2764905) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2764896) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" S_feature complement(2764898..2764998) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2764919..2764925) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2765030..2765968) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" gene complement(2765030..2765968) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" downshifts complement(2765043) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" CDS complement(2766012..2767283) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" gene complement(2766012..2767283) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" misc_feature complement(2767068..2767087) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2767080) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" S_feature complement(2767284..2767366) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2767366) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" S_feature complement(2767368..2767446) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2767368..2767387) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2767403..2767407) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2767447..2768565) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" gene complement(2767447..2768565) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" downshifts 2768060 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" misc_feature 2768407..2768410 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2768415 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2768544 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2768566..2768772) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2768740..2768752 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2768751 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2768758..2768777) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768772) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" promotor_-35 complement(2768792..2768796) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2768892) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" CDS complement(2768899..2769363) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" gene complement(2768899..2769363) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" promotor_-10 complement(2769376..2769395) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769390) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" S_feature complement(2769392..2770577) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2769392..2769397 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2769408..2769416) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2769412..2769430 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2769418 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" CDS 2769460..2770575 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" gene 2769460..2770575 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" downshifts 2770546 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" CDS complement(2770608..2770991) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" gene complement(2770608..2770991) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" downshifts complement(2770622) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" S_feature complement(2770992..2771083) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2771084..2772841) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" gene complement(2771084..2772841) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" CDS complement(2772884..2773843) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" gene complement(2772884..2773843) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" S_feature complement(2773844..2773945) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2773934..2773953) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773945) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2773969..2773973) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774027..2775004) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" gene complement(2774027..2775004) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" downshifts complement(2774054) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" CDS complement(2774989..2775861) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" gene complement(2774989..2775861) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" promotor_-35 2775823..2775828 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2775844..2775862 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2775848..2777022 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2775848 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" S_feature complement(2775862..2775945) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2775934..2775953) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775945) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" S_feature complement(2775947..2776099) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2775969..2775973) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2776101..2776195) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2776144) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" CDS complement(2776196..2777428) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" gene complement(2776196..2777428) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" S_feature complement(2777429..2777545) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2777533..2777552) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2777545) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" CDS complement(2777565..2780912) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" gene complement(2777565..2780912) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" promotor_-35 complement(2777566..2777573) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2778577..2778586 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2778598..2778613 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778598 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2778786..2778805) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778805) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2778819..2778826) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2780943..2780962) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2780961) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" promotor_-35 complement(2780976..2780983) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2781001..2781006 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2781018 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" promotor_-10 2781022..2781040 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2781052..2781393 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" gene 2781052..2781393 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" CDS 2781390..2781893 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" gene 2781390..2781893 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" promotor_-35 2781926..2781929 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781944..2781963 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2781944 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" CDS 2781995..2782186 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" gene 2781995..2782186 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" downshifts complement(2781996) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" downshifts 2782162 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" CDS complement(2782204..2783145) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" gene complement(2782204..2783145) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" S_feature 2782207..2782578 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2782239) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2782547..2782556 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2782570..2782589 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2782580..2782974 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2782580 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-35 2782936..2782942 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2782958..2782977 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2782976..2783275 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2782976 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-10 complement(2783164..2783183) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2783180) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" S_feature complement(2783182..2783596) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2783198..2783201) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2783276..2783578 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" gene 2783276..2783578 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" S_feature 2783579..2785374 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2783597..2784916) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" gene complement(2783597..2784916) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" promotor_-10 complement(2784942..2784961) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784963) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" promotor_-35 complement(2784976..2784981) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2785092..2785994) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" gene complement(2785092..2785994) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" CDS complement(2786013..2787263) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" gene complement(2786013..2787263) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" CDS complement(2787281..2787973) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" gene complement(2787281..2787973) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" CDS complement(2788020..2789348) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" gene complement(2788020..2789348) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" CDS complement(2789345..2789626) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" gene complement(2789345..2789626) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" CDS complement(2789641..2790645) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" gene complement(2789641..2790645) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" CDS complement(2790642..2791421) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" gene complement(2790642..2791421) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" CDS complement(2791418..2792125) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" gene complement(2791418..2792125) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" CDS complement(2792155..2792874) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" gene complement(2792155..2792874) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" promotor_-35 2792700..2792707 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2792722..2792741 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2792722 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2792896..2793708) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" gene complement(2792896..2793708) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" CDS complement(2793722..2794531) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" gene complement(2793722..2794531) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" CDS complement(2794545..2795081) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" gene complement(2794545..2795081) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" promotor_-35 2795118..2795125 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2795136..2795155) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2795139..2795158 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2795142..2795233 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2795142 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" upshifts complement(2795152) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" promotor_-35 complement(2795169..2795176) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2795234..2796160 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" gene 2795234..2796160 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" S_feature complement(2795636..2796165) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2796210) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" CDS complement(2796211..2796894) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" gene complement(2796211..2796894) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" S_feature complement(2796895..2796956) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2796957..2797724) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" gene complement(2796957..2797724) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" promotor_-10 complement(2797769..2797788) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797791) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" promotor_-35 complement(2797804..2797806) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2797851..2798087) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" gene complement(2797851..2798087) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" downshifts 2797936 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" downshifts complement(2797956) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" CDS complement(2798047..2799432) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" gene complement(2798047..2799432) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" CDS complement(2799429..2800640) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" gene complement(2799429..2800640) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" S_feature complement(2800641..2800718) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2800711..2800730) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800717) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" promotor_-35 complement(2800745..2800752) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2800810..2801322) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" gene complement(2800810..2801322) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" downshifts complement(2800828) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2801348..2801367) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801356) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" promotor_-35 complement(2801381..2801388) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801407..2802594) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" gene complement(2801407..2802594) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" downshifts complement(2801422) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" S_feature complement(2802595..2802699) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2802684..2802703) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2802699) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" S_feature complement(2802701..2802830) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2802719..2802723) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2802767..2802970) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" gene complement(2802767..2802970) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" promotor_-10 complement(2802828..2802839) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2802830) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" promotor_-35 complement(2802854..2802860) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2802942..2803931) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" gene complement(2802942..2803931) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" downshifts complement(2802960) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" CDS complement(2803992..2804495) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" gene complement(2803992..2804495) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" downshifts complement(2803998) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" promotor_no_box 2804212..2804312 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2804272 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2804491 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2804518..2804537) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804534) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" promotor_-35 complement(2804551..2804558) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2804605..2805060) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" gene complement(2804605..2805060) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" downshifts complement(2804633) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" CDS complement(2805074..2805754) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" gene complement(2805074..2805754) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" upshifts complement(2805166) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" promotor_-10 complement(2805173..2805184) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2805199..2805205) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2805492) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(2805767..2805785) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2805781) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" promotor_-35 complement(2805800..2805805) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2805829..2806323) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" gene complement(2805829..2806323) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" downshifts complement(2805844) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" CDS complement(2806336..2807343) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" gene complement(2806336..2807343) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" promotor_-10 complement(2807367..2807382) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807384) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" S_feature complement(2807386..2807465) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2807394..2807403) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2807443..2807462 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2807453 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" promotor_-10 complement(2807458..2807477) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2807462..2807528 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2807465) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" promotor_-35 complement(2807493..2807497) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2807529..2808332 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" gene 2807529..2808332 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" downshifts 2808262 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" downshifts 2808320 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" CDS complement(2808364..2809953) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" gene complement(2808364..2809953) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" downshifts complement(2808373) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" CDS complement(2809973..2811562) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" gene complement(2809973..2811562) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" promotor_-10 complement(2811608..2811625) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811613) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" promotor_-35 complement(2811641..2811647) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2811740) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" CDS complement(2811741..2811950) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" gene complement(2811741..2811950) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" promotor_-35 2811946..2811950 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2811950 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2811959..2811973 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2811971..2811982) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811982) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" promotor_-35 complement(2811997..2812003) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2812044..2813249) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" gene complement(2812044..2813249) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" CDS complement(2813253..2814398) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" gene complement(2813253..2814398) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" S_feature complement(2814399..2815542) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2814485..2814492 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2814503..2814592 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2814503 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" promotor_-10 2814505..2814524 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2814593..2815930 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" gene 2814593..2815930 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" promotor_-10 complement(2815528..2815547) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815542) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" promotor_-35 complement(2815562..2815569) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2815906 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" CDS complement(2816025..2817713) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" gene complement(2816025..2817713) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" downshifts complement(2816026) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2817714..2817819) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2817796..2817804 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2817807..2817826) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2817815..2817834 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817819) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" upshifts 2817819 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2817820..2817909 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2817821..2818380) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2817842..2817844) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2817910..2818716 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" gene 2817910..2818716 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" promotor_-10 complement(2818384..2818403) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818397) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" promotor_-35 complement(2818415..2818422) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2818666..2818712) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2818688) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" CDS complement(2818713..2819336) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" gene complement(2818713..2819336) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" S_feature 2818717..2819059 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2819037..2819044 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2819059..2819078 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2819061..2819204 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2819061 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" promotor_-35 2819176..2819180 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2819196..2819215 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2819206..2819336 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2819206 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2819338..2819462 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2819338 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" promotor_-10 complement(2819352..2819370) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2819354..2819373 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2819370) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" promotor_-35 complement(2819381..2819389) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2819463..2819954 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" gene 2819463..2819954 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" downshifts 2819933 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" CDS complement(2819992..2821731) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" gene complement(2819992..2821731) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" downshifts complement(2820010) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" promotor_-35 2821205..2821212 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2821226..2821244 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2821229 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" S_feature 2821231..2821826 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2821761..2821780) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2821769) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" S_feature complement(2821771..2822604) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2821807..2821814 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2821828..2822025 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2821828..2821847 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821828 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" misc_RNA 2821885..2822017 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" gene 2821885..2822017 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" CDS 2822026..2822628 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" gene 2822026..2822628 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" downshifts 2822551 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" S_feature complement(2822606..2822825) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2822614 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" downshifts complement(2822649) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" downshifts 2822661 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" S_feature 2822706..2822879 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2822821..2822839) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822833) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" downshifts 2822837 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2822854..2822860) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2822899..2824167) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" gene complement(2822899..2824167) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" downshifts complement(2822925) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" misc_RNA complement(2824191..2824464) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" gene complement(2824191..2824464) /gene="tboY" /locus_tag="BSU_misc_RNA_83" S_feature complement(2824212..2824355) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2824255) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(2824462..2824481) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824474) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2824494..2824501) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2824509..2826227) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" gene complement(2824509..2826227) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" promotor_-35 2826241..2826248 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2826255..2826274) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2826263..2826282 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826269 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2826278) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2826288..2826294) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2826311..2826318 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2826332..2826351 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826335 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" CDS 2826388..2827020 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" gene 2826388..2827020 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" promotor_-35 2826593..2826601 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2826615..2826634 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826621 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" CDS 2827047..2827691 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" gene 2827047..2827691 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" CDS 2827688..2828851 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" gene 2827688..2828851 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" downshifts 2828842 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" CDS complement(2828862..2829590) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" gene complement(2828862..2829590) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" downshifts complement(2828898) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" CDS complement(2829580..2830398) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" gene complement(2829580..2830398) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" CDS complement(2830461..2831465) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" gene complement(2830461..2831465) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" downshifts complement(2830478) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" misc_feature complement(2831500..2831519) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2831515) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" S_feature complement(2831517..2831625) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2831625..2831644) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831625) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" S_feature complement(2831627..2831692) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2831658..2831664) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2831738) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" CDS complement(2831741..2832817) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" gene complement(2831741..2832817) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" promotor_-10 complement(2832858..2832877) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2832878) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" S_feature complement(2832880..2832980) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2832892..2832899) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2832914 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" promotor_-10 complement(2832968..2832987) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832980) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" promotor_-35 complement(2833001..2833007) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2833053..2833379) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" gene complement(2833053..2833379) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" downshifts complement(2833062) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" CDS complement(2833403..2833858) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" gene complement(2833403..2833858) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" CDS complement(2833889..2834311) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" gene complement(2833889..2834311) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" promotor_-10 complement(2834332..2834350) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834345) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" promotor_-35 complement(2834364..2834370) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2834384..2834402) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2834393) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" promotor_-35 complement(2834413..2834421) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2834473..2835771) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" gene complement(2834473..2835771) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" downshifts complement(2834482) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(2835796..2835815) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835797) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" S_feature complement(2835799..2835995) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2835828..2835837) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2835978..2835997) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835995) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" promotor_-35 complement(2836009..2836015) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2836021..2838879) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" gene complement(2836021..2838879) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" promotor_-10 complement(2838913..2838932) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2838923) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" promotor_-35 complement(2838948..2838952) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2839022) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" CDS complement(2839039..2839644) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" gene complement(2839039..2839644) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" CDS complement(2839660..2840469) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" gene complement(2839660..2840469) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" CDS complement(2840484..2840807) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" gene complement(2840484..2840807) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" S_feature complement(2840808..2840946) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2840846..2840962) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" gene complement(2840846..2840962) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" promotor_-10 complement(2840933..2840952) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2840946) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" promotor_-35 2840954..2840961 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2840968) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-35" promotor_-10 2840976..2840995 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2840981 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" CDS 2841042..2841488 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" gene 2841042..2841488 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" S_feature 2841489..2842217 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2841543..2842616) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" gene complement(2841543..2842616) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" downshifts complement(2841562) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2842638..2842657) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842642) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" promotor_-35 complement(2842671..2842678) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2842713..2842716 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2842731..2842750 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2842736 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" CDS 2842775..2843092 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" gene 2842775..2843092 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" downshifts 2843092 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" CDS complement(2843145..2844845) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" gene complement(2843145..2844845) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" downshifts complement(2843164) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(2844877..2844895) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844884) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" promotor_-35 complement(2844910..2844916) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2844927..2845697) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" gene complement(2844927..2845697) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" S_feature complement(2845698..2845786) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2845784..2845803) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845786) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" promotor_-35 complement(2845819..2845823) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2845843..2846484) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" gene complement(2845843..2846484) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" downshifts complement(2845853) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" downshifts complement(2845918) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(2846510..2846529) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846519) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" S_feature complement(2846521..2846969) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2846545..2846549) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2846628..2846634 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2846649..2846660 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2846656 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" CDS 2846691..2846969 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" gene 2846691..2846969 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" S_feature 2846970..2847140 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2846970..2847584) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" gene complement(2846970..2847584) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" downshifts 2847118 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" S_feature complement(2847585..2847920) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2847912..2847931) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2847920) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" promotor_-35 complement(2847946..2847953) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2847947..2850103) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" gene complement(2847947..2850103) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" CDS complement(2850129..2851058) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" gene complement(2850129..2851058) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" CDS complement(2851107..2852021) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" gene complement(2851107..2852021) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" promotor_-10 complement(2851784..2851802) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2851792) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2851816..2851822) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2852047..2852598) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" gene complement(2852047..2852598) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" misc_feature 2852461..2852480 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2852464 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2852621..2852640) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2852633) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2852656..2852659) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2852681..2852688 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2852699..2852718 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2852702..2852713) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2852706 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" upshifts complement(2852716) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" promotor_-35 complement(2852727..2852733) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2852747..2853682 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" gene 2852747..2853682 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" downshifts 2853658 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" CDS complement(2853716..2855107) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" gene complement(2853716..2855107) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" downshifts complement(2853728) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" S_feature complement(2855108..2855548) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2855134..2855139 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2855153..2855172 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2855166 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" CDS 2855204..2856502 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" gene 2855204..2856502 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" promotor_-10 complement(2855525..2855544) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855548) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" promotor_-35 complement(2855559..2855565) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2856489 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" CDS complement(2856542..2857699) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" gene complement(2856542..2857699) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" downshifts complement(2856567) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" promotor_-35 2856815..2856820 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2856835..2856853 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2856843 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2857696..2858406) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" gene complement(2857696..2858406) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" promotor_-10 complement(2858420..2858435) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858437) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" promotor_-35 complement(2858447..2858456) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2858463..2858464 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2858476..2858581 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2858476 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" promotor_-10 2858484..2858494 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2858547..2858553 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2858568..2858587 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2858583..2858696 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2858583 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" CDS 2858697..2858918 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" gene 2858697..2858918 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" downshifts 2858901 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" downshifts 2858970 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" CDS complement(2859039..2859758) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" gene complement(2859039..2859758) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" downshifts complement(2859053) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" downshifts complement(2859824) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" CDS complement(2859827..2861461) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" gene complement(2859827..2861461) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" misc_feature complement(2861493..2861512) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2861509) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" promotor_-35 2861579..2861583 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2861599..2861618 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2861617 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" CDS 2861663..2862925 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" gene 2861663..2862925 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" S_feature 2862926..2863024 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2862998..2863004 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2863020..2863038 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2863026..2863113 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2863026 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" CDS 2863114..2864652 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" gene 2863114..2864652 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" downshifts 2864632 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" CDS complement(2864689..2864871) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" gene complement(2864689..2864871) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" downshifts complement(2864708) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2864886..2864904) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864906) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" promotor_-35 complement(2864920..2864925) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2864939..2865607) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" gene complement(2864939..2865607) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" CDS complement(2865629..2866915) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" gene complement(2865629..2866915) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" CDS complement(2866927..2867430) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" gene complement(2866927..2867430) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" CDS complement(2867427..2868548) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" gene complement(2867427..2868548) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" CDS complement(2868556..2869521) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" gene complement(2868556..2869521) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" upshifts complement(2869547) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" promotor_-10 complement(2869548..2869567) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2869582..2869589) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2869677..2869684 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2869697 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" promotor_-10 2869700..2869719 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2869737..2872055 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" gene 2869737..2872055 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" downshifts 2872045 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" CDS complement(2872096..2873592) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" gene complement(2872096..2873592) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" downshifts complement(2872098) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" CDS complement(2873617..2874477) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" gene complement(2873617..2874477) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" promotor_-10 complement(2874553..2874572) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2874562) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" promotor_-35 complement(2874588..2874595) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2874684..2875445) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" gene complement(2874684..2875445) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" downshifts complement(2874713) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2875446..2875521) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2875522..2876709) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" gene complement(2875522..2876709) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" CDS complement(2876778..2877785) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" gene complement(2876778..2877785) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" CDS complement(2877788..2878483) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" gene complement(2877788..2878483) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" CDS complement(2878480..2879649) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" gene complement(2878480..2879649) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" promotor_-35 2878516..2878523 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878538..2878557 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878556 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2879639..2880985) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" gene complement(2879639..2880985) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" promotor_-35 2880055..2880059 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2880074 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2880075..2880093 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2880975..2881751) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" gene complement(2880975..2881751) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" S_feature complement(2881752..2881844) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2881830..2881849) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881844) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" promotor_-35 complement(2881864..2881871) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2881961..2882860) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" gene complement(2881961..2882860) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" promotor_-10 complement(2882883..2882901) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882900) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2882912..2882920) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2882990..2882997 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883013..2883032 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883019 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2883078..2884112 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" gene 2883078..2884112 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" promotor_-35 2884061..2884068 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884083..2884091 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2884100 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2884146..2885426 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" gene 2884146..2885426 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" CDS 2885419..2886330 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" gene 2885419..2886330 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" CDS 2886327..2887157 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" gene 2886327..2887157 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" promotor_-35 2887130..2887134 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887150..2887169 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2887158 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2887177..2888475 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" gene 2887177..2888475 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" downshifts 2888456 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" CDS complement(2888497..2888808) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" gene complement(2888497..2888808) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" downshifts complement(2888508) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(2888832..2888851) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888840) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" promotor_-35 complement(2888866..2888873) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2888874 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" CDS complement(2888925..2891339) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" gene complement(2888925..2891339) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" downshifts complement(2888929) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" S_feature complement(2891340..2891435) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2891449..2891663) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" gene complement(2891449..2891663) /gene="tboL" /locus_tag="BSU_misc_RNA_49" downshifts complement(2891480) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2891675..2891694) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2891696) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" promotor_-35 2891700..2891705 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2891709..2891714) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891721..2891739 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2891734..2892174 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2891734 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" CDS complement(2891766..2892101) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" gene complement(2891766..2892101) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" S_feature complement(2892096..2892360) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2892345..2892364) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2892360) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" promotor_-35 complement(2892379..2892386) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2892399..2892406 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892420..2892439 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2892436 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" S_feature 2892438..2892505 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2892506..2893291 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" gene 2892506..2893291 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" S_feature 2893292..2893348 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2893528..2894721) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" gene complement(2893528..2894721) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" downshifts complement(2893548) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" S_feature complement(2894722..2894820) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2894801..2894820) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894820) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" promotor_-35 complement(2894834..2894841) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2894858..2894861 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2894876..2894895 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2894880 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" CDS 2894910..2895656 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" gene 2894910..2895656 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" downshifts 2895551 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" downshifts 2895650 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" CDS complement(2895693..2897633) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" gene complement(2895693..2897633) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" downshifts complement(2895704) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" CDS complement(2897623..2898384) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" gene complement(2897623..2898384) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" misc_feature complement(2898408..2898426) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2898427) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" CDS complement(2898486..2899490) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" gene complement(2898486..2899490) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" downshifts complement(2898525) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" CDS complement(2899483..2900178) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" gene complement(2899483..2900178) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" promotor_-10 complement(2900202..2900220) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900214) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2900236..2900239) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2900275..2901585) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" gene complement(2900275..2901585) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" downshifts complement(2900297) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" CDS complement(2901575..2902270) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" gene complement(2901575..2902270) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" CDS complement(2902285..2903262) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" gene complement(2902285..2903262) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" CDS complement(2903292..2904278) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" gene complement(2903292..2904278) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" promotor_-35 2904148..2904157 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2904164 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2904170..2904185 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2904272..2905150) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" gene complement(2904272..2905150) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" CDS complement(2905143..2905535) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" gene complement(2905143..2905535) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" S_feature complement(2905536..2905780) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2905569..2905706) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" gene complement(2905569..2905706) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" downshifts 2905704 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(2905775..2905794) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2905780) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2905808..2905815) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2905861..2906133) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" gene complement(2905861..2906133) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" downshifts complement(2905868) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2906173..2906184) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2906177..2906185 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2906177) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" upshifts 2906188 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" promotor_-10 2906199..2906217 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2906199..2906205) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2906228..2906233 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906247..2906266 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906254 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" CDS 2906295..2907263 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" gene 2906295..2907263 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" CDS 2907260..2907844 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" gene 2907260..2907844 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" downshifts 2907808 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" CDS complement(2907834..2908937) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" gene complement(2907834..2908937) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" downshifts complement(2907875) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" CDS complement(2908958..2909737) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" gene complement(2908958..2909737) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" promotor_-35 2909380..2909387 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2909402..2909421 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2909419 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" S_feature complement(2909738..2910317) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2909786..2910301 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" gene 2909786..2910301 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" promotor_-10 complement(2910308..2910327) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910317) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" S_feature complement(2910319..2910453) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2910339..2910346) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2910428..2910447) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2910453) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" CDS complement(2910546..2911937) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" gene complement(2910546..2911937) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" downshifts complement(2910554) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" S_feature complement(2911938..2912072) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2912073..2913971) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" gene complement(2912073..2913971) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" promotor_-35 2913129..2913135 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913150..2913161 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913162 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2913972..2914095) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2914121..2915323) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" gene complement(2914121..2915323) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" downshifts complement(2914140) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(2915366..2915377) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915372) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" S_feature complement(2915374..2915490) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2915391..2915397) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2915491..2915629) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2915491..2915629) /gene="mswG" /locus_tag="BSU_misc_RNA_50" downshifts 2915589 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" promotor_-10 complement(2915638..2915657) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2915653) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" promotor_-35 complement(2915674..2915678) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2915750..2915757 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2915769 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" promotor_-10 2915771..2915790 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2915826..2917409 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" gene 2915826..2917409 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" downshifts 2917398 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" CDS complement(2917448..2917690) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" gene complement(2917448..2917690) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" downshifts complement(2917462) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" CDS complement(2917742..2918515) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" gene complement(2917742..2918515) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" S_feature complement(2918516..2918606) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2918582..2918591 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2918595..2918614) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918603 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" promotor_-10 2918604..2918623 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918608) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" promotor_-35 complement(2918629..2918636) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2918666..2919670 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" gene 2918666..2919670 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" CDS 2919683..2920465 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" gene 2919683..2920465 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" S_feature complement(2919687..2921235) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2920440..2921252 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" gene 2920440..2921252 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" downshifts 2921237 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" CDS complement(2921279..2921755) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" gene complement(2921279..2921755) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" downshifts complement(2921280) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" misc_feature complement(2921785..2921804) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2921798) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" S_feature complement(2921800..2921934) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2921934) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" promotor_-10 complement(2921936..2921947) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2921962..2921968) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2921964..2922368) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" gene complement(2921964..2922368) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" promotor_-10 complement(2922396..2922415) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922413) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2922415..2922501) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2922428..2922437) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2922534..2922971) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" gene complement(2922534..2922971) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" downshifts complement(2922546) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2922988..2923006) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923006) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2923008..2923233) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2923021..2923027) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2923063..2923082 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2923064..2923240 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" gene 2923064..2923240 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" upshifts 2923065 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" CDS complement(2923234..2923671) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" gene complement(2923234..2923671) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" downshifts 2923260 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2923690..2923709) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2923711) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" promotor_-35 complement(2923720..2923728) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2923791..2924264) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" gene complement(2923791..2924264) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" downshifts complement(2923800) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" downshifts complement(2923887) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" S_feature complement(2924265..2924616) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2924336..2924343 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924356..2924375 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924361 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2924393..2924620 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" gene 2924393..2924620 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" CDS complement(2924617..2925180) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" gene complement(2924617..2925180) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" misc_feature complement(2925205..2925224) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2925220) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" CDS complement(2925274..2925522) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" gene complement(2925274..2925522) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" downshifts complement(2925295) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" promotor_-10 complement(2925550..2925569) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2925583..2925590) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2925587) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" promotor_-35 2925649..2925655 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2925669..2925680 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2925681 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" CDS 2925727..2927058 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" gene 2925727..2927058 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" CDS 2927102..2928142 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" gene 2927102..2928142 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" promotor_-35 2928136..2928142 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928157..2928168 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928167 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" CDS 2928196..2928354 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" gene 2928196..2928354 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" downshifts 2928343 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" CDS complement(2928373..2929260) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" gene complement(2928373..2929260) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" downshifts complement(2928396) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" CDS complement(2929250..2930557) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" gene complement(2929250..2930557) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" CDS complement(2930563..2931315) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" gene complement(2930563..2931315) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" CDS complement(2931334..2932254) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" gene complement(2931334..2932254) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" promotor_-10 complement(2932290..2932301) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2932291) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2932293..2932384) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2932315..2932321) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2932369 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2932370..2932389) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2932372..2932384 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2932384) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" S_feature complement(2932386..2932467) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2932404..2932411) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2932467) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" promotor_-10 complement(2932476..2932495) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2932509..2932516) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2932534..2933649) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" gene complement(2932534..2933649) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" downshifts complement(2932577) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" CDS complement(2933646..2935106) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" gene complement(2933646..2935106) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" promotor_-10 complement(2934549..2934567) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934553) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" promotor_-35 complement(2934582..2934588) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2935195) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" CDS complement(2935197..2936012) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" gene complement(2935197..2936012) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" CDS complement(2936047..2936871) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" gene complement(2936047..2936871) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" promotor_-10 complement(2936129..2936148) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2936129) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" promotor_-35 complement(2936164..2936167) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2936295) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" promotor_-10 complement(2936305..2936316) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2936331..2936337) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2936859..2938601) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" gene complement(2936859..2938601) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" CDS complement(2938598..2940013) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" gene complement(2938598..2940013) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" S_feature complement(2940014..2940126) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2940106..2940125) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2940126) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" S_feature complement(2940128..2940278) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2940141..2940144) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2940239..2940245 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2940259..2940278) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2940259..2940270 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940267 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" upshifts complement(2940278) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" promotor_-35 complement(2940292..2940301) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2940303..2941022 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" gene 2940303..2941022 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" S_feature complement(2940373..2941030) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2941011 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" CDS complement(2941031..2941849) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" gene complement(2941031..2941849) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" promotor_-10 complement(2941870..2941889) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941884) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" promotor_-35 complement(2941904..2941912) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2941950..2941958 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2941971..2941990 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941972 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" CDS 2942021..2943307 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" gene 2942021..2943307 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" CDS 2943304..2944254 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" gene 2943304..2944254 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" CDS 2944257..2945480 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" gene 2944257..2945480 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" downshifts complement(2945404) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" S_feature 2945481..2946048 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2945554..2945985) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" gene complement(2945554..2945985) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" downshifts complement(2945580) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" CDS complement(2945987..2947042) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" gene complement(2945987..2947042) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" CDS complement(2947057..2948190) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" gene complement(2947057..2948190) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" promotor_-10 complement(2948223..2948242) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2948242) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" promotor_-35 complement(2948255..2948264) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2948328..2948337 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948351..2948370 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948353 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" CDS 2948380..2949453 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" gene 2948380..2949453 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" promotor_-35 2948677..2948683 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2948694 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2948697..2948708 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2949442 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" promotor_-35 2949480..2949486 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2949501 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2949502..2949520 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2949533..2950000 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" gene 2949533..2950000 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" downshifts 2949972 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" CDS complement(2950031..2952427) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" gene complement(2950031..2952427) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" downshifts complement(2950046) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" CDS complement(2952414..2953868) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" gene complement(2952414..2953868) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" CDS complement(2953865..2954896) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" gene complement(2953865..2954896) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" CDS complement(2954920..2956062) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" gene complement(2954920..2956062) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" CDS complement(2956059..2957942) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" gene complement(2956059..2957942) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" S_feature 2956768..2958187 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2957974..2957989) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957987) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" promotor_-35 complement(2958004..2958009) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2958054) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" tRNA complement(2958175..2958246) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958175..2958246) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" tRNA complement(2958272..2958362) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958272..2958362) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" tRNA complement(2958366..2958440) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958366..2958440) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" tRNA complement(2958451..2958527) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958451..2958527) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" tRNA complement(2958543..2958616) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958543..2958616) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" tRNA complement(2958627..2958702) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958627..2958702) /gene="trnB-His" /locus_tag="BSU_tRNA_67" tRNA complement(2958720..2958795) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958720..2958795) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" tRNA complement(2958808..2958884) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958808..2958884) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" tRNA complement(2958896..2958972) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958896..2958972) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" tRNA complement(2958990..2959082) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2958990..2959082) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" tRNA complement(2959089..2959165) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959089..2959165) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" tRNA complement(2959168..2959244) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959168..2959244) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" tRNA complement(2959264..2959336) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959264..2959336) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" tRNA complement(2959342..2959418) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959342..2959418) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" tRNA complement(2959434..2959510) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959434..2959510) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" tRNA complement(2959520..2959605) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959520..2959605) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" tRNA complement(2959620..2959694) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959620..2959694) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" tRNA complement(2959700..2959786) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959700..2959786) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" tRNA complement(2959797..2959872) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959797..2959872) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" tRNA complement(2959910..2959985) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2959910..2959985) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" tRNA complement(2960018..2960093) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2960018..2960093) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" rRNA complement(2960114..2960231) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2960114..2960231) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" rRNA complement(2960287..2963214) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2960287..2963214) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" rRNA complement(2963382..2964936) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2963382..2964936) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" S_feature complement(2964937..2965228) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2965064..2965072 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2965070 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2965180 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2965201..2965220) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2965228) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" S_feature complement(2965230..2966196) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2965234..2965241) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2965353..2965356 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2965368 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" promotor_-10 2965371..2965390 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2965401..2965502 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 2965401..2965502 /gene="tswC" /locus_tag="BSU_misc_RNA_51" downshifts 2965501 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" CDS 2965602..2966180 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" gene 2965602..2966180 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" downshifts 2966170 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" CDS complement(2966222..2966743) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" gene complement(2966222..2966743) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" downshifts complement(2966240) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" downshifts complement(2966312) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" CDS complement(2966761..2968290) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" gene complement(2966761..2968290) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" CDS complement(2968311..2968835) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" gene complement(2968311..2968835) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" promotor_-10 complement(2968879..2968894) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2968885) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" S_feature complement(2968887..2968974) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2968906..2968915) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2968959..2968977) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968969 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" misc_feature 2968973..2968992 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2968974) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" promotor_-35 complement(2968992..2968997) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2969003..2969491 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" gene 2969003..2969491 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" downshifts 2969468 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" CDS complement(2969497..2970075) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" gene complement(2969497..2970075) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" S_feature 2969513..2969904 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2969524) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2970109..2970128) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970118) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" promotor_-35 complement(2970142..2970149) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2970163..2971371) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" gene complement(2970163..2971371) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" downshifts complement(2970184) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2971140..2971159) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971152) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2971174..2971181) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2971388..2972860) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" gene complement(2971388..2972860) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" promotor_-10 complement(2972911..2972930) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2972912) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" promotor_-35 complement(2972945..2972952) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2972972..2972978 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2972992..2973011 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973007 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" CDS 2973059..2973601 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" gene 2973059..2973601 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" downshifts 2973584 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" promotor_-35 2973678..2973685 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2973698..2973798 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2973698 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" promotor_-10 2973700..2973719 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2973799..2974344 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" gene 2973799..2974344 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" downshifts 2974331 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2974436..2974443 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974457..2974476 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974464 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" misc_RNA 2974469..2974637 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" gene 2974469..2974637 /gene="swdA" /locus_tag="BSU_misc_RNA_52" downshifts 2974618 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" CDS 2974710..2975378 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" gene 2974710..2975378 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" CDS 2975385..2976722 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" gene 2975385..2976722 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" downshifts 2976708 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" CDS complement(2976758..2977021) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" gene complement(2976758..2977021) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" downshifts complement(2976776) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" promotor_-10 complement(2977061..2977080) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2977063) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" promotor_-35 complement(2977093..2977100) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2977130..2977978) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" gene complement(2977130..2977978) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" promotor_-10 complement(2978023..2978042) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978033) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" promotor_-35 complement(2978057..2978064) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2978139..2979674) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" gene complement(2978139..2979674) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" downshifts complement(2978148) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" promotor_no_box 2979332..2979432 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2979392 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2979458 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" S_feature complement(2979675..2979842) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2979831..2979850) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2979842) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" S_feature complement(2979844..2980721) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2979865..2979872) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2980084..2980093 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980107..2980126 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980107 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" CDS 2980159..2980644 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" gene 2980159..2980644 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" S_feature 2980645..2980931 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2980751..2980823) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene complement(2980751..2980823) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" downshifts complement(2980766) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" downshifts complement(2980810) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(2980834..2980853) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980854) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" promotor_-35 complement(2980868..2980871) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2980888 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" CDS complement(2980931..2981761) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" gene complement(2980931..2981761) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" downshifts complement(2980942) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2981762..2981853) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2981854..2983020) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" gene complement(2981854..2983020) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" promotor_-35 2983016..2983020 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2983028..2983042 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2983044..2983063) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2983044 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2983063) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" promotor_-35 complement(2983077..2983084) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2983142..2983149 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2983155 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" promotor_-10 2983160..2983179 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2983202..2984188 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" gene 2983202..2984188 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" downshifts 2984159 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" CDS complement(2984229..2985503) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" gene complement(2984229..2985503) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" downshifts complement(2984242) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" CDS complement(2985529..2985843) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" gene complement(2985529..2985843) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" CDS complement(2985861..2987318) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" gene complement(2985861..2987318) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" CDS complement(2987323..2988099) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" gene complement(2987323..2988099) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" misc_feature complement(2988133..2988152) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2988149) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" CDS complement(2988156..2990225) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" gene complement(2988156..2990225) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" promotor_-10 complement(2990258..2990277) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990270) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" promotor_-35 complement(2990291..2990297) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2990363..2992351) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" gene complement(2990363..2992351) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" downshifts complement(2990382) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2992355..2992362 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2992372..2992390) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2992378..2992397 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992385) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" upshifts 2992394 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2992404..2992411) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2992460 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" CDS complement(2992465..2994450) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" gene complement(2992465..2994450) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" downshifts complement(2992470) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2994471..2994489) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2994486) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" S_feature complement(2994488..2994575) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2994503..2994510) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2994576..2996564) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" gene complement(2994576..2996564) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" promotor_-10 complement(2996589..2996607) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2996604) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" promotor_-35 complement(2996621..2996628) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2996741..2998729) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" gene complement(2996741..2998729) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" downshifts complement(2996760) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2998750..2998768) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998771) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" promotor_-35 complement(2998781..2998788) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2998831..2998840 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998854..2998873 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998857 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" CDS 2998887..2999624 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" gene 2998887..2999624 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" promotor_-10 complement(2998912..2998931) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2998920) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" promotor_-35 complement(2998947..2998951) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2999625..3002445 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2999638..2999892) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" gene complement(2999638..2999892) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" downshifts complement(2999664) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" S_feature complement(2999893..3000149) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(3000150..3000548) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" gene complement(3000150..3000548) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" CDS complement(3000508..3000642) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" gene complement(3000508..3000642) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" promotor_-10 complement(3000591..3000610) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000598) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" promotor_-35 complement(3000625..3000631) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3000668..3002332) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" gene complement(3000668..3002332) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" downshifts complement(3000684) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3001640..3001659) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001645) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3001673..3001680) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3002357..3002375) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002374) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" promotor_-35 complement(3002391..3002396) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3002459..3003748) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" gene complement(3002459..3003748) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" downshifts complement(3002468) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" promotor_-35 3003277..3003283 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003297..3003315 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003303 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" S_feature 3003307..3003959 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(3003792..3004469) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" gene complement(3003792..3004469) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" downshifts complement(3003802) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" S_feature 3004144..3004820 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(3004504..3004523) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3004511..3004774) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" gene complement(3004511..3004774) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" upshifts complement(3004525) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(3004537..3004544) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3004786..3004804) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004800) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(3004820..3004825) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3004821..3005153 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" gene 3004821..3005153 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" promotor_-35 3004838..3004844 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004859..3004876 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3004870 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" CDS 3005150..3006136 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" gene 3005150..3006136 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" downshifts complement(3006111) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" CDS complement(3006133..3006537) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" gene complement(3006133..3006537) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" S_feature complement(3006538..3006596) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(3006597..3006968) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" gene complement(3006597..3006968) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" CDS complement(3007027..3008379) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" gene complement(3007027..3008379) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" downshifts complement(3007038) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" promotor_-10 complement(3007194..3007212) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007211) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" promotor_-35 complement(3007228..3007233) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3008352) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" misc_feature complement(3008355..3008366) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3008411..3008430) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008417) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" S_feature complement(3008419..3008490) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(3008445..3008448) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3008491..3009663) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" gene complement(3008491..3009663) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" S_feature 3008826..3009747 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(3009696..3009715) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(3009709) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" promotor_-35 complement(3009732..3009735) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(3009767..3010930) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" gene complement(3009767..3010930) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" downshifts complement(3009782) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3010945..3010964) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(3010963) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" S_feature complement(3010965..3011120) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(3010979..3010986) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 3011016..3011022 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3011037..3011055 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3011047 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" S_feature 3011048..3011106 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 3011093..3011099 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3011095..3011106) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3011108 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" promotor_-10 3011113..3011124 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3011120..3011126) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3011120) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" S_feature complement(3011122..3011433) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 3011160..3011396 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" gene 3011160..3011396 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" downshifts 3011356 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" downshifts 3011422 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" CDS complement(3011474..3011866) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" gene complement(3011474..3011866) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" downshifts complement(3011478) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3011908..3011927) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(3011915) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" S_feature complement(3011917..3012067) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(3011943..3011947) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 3011970..3011976 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3011983..3012967 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 3011983 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" promotor_-10 3011991..3012009 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3012068..3013228) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" gene complement(3012068..3013228) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" promotor_-35 3013120..3013126 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3013138 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3013140..3013144 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3013229..3013729) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" gene complement(3013229..3013729) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" promotor_-10 complement(3013759..3013778) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 3013765..3013771 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3013780) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" promotor_-10 3013786..3013797 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3013786 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" promotor_-35 complement(3013789..3013796) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 3013798..3013876 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 3013877..3014698 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" gene 3013877..3014698 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" downshifts 3014678 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" downshifts complement(3014725) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" CDS complement(3014727..3014987) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" gene complement(3014727..3014987) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" promotor_-35 3014977..3014980 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 3014995..3015014 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 3015007 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" S_feature 3015008..3015073 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(3015013..3015032) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015018) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" promotor_-35 complement(3015044..3015050) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3015074..3016237 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" gene 3015074..3016237 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" promotor_-35 3016300..3016306 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016318..3016337 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3016328 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" CDS 3016363..3017649 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" gene 3016363..3017649 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" S_feature complement(3017365..3018107) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 3017644..3017651 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3017665..3017684 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3017666 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" CDS 3017695..3018081 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" gene 3017695..3018081 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" downshifts 3018063 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" CDS complement(3018108..3018725) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" gene complement(3018108..3018725) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" promotor_-10 complement(3018760..3018778) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3018777) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" S_feature complement(3018779..3020867) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(3018793..3018798) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3018841..3018844 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 3018859..3018878 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 3018870 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" CDS 3018936..3020114 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" gene 3018936..3020114 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" promotor_-35 3020152..3020158 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3020170..3020189 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3020175 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" CDS 3020207..3022081 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" gene 3020207..3022081 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" promotor_-10 complement(3020847..3020866) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3020867) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" promotor_-35 complement(3020880..3020889) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3022102..3022515 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" gene 3022102..3022515 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" downshifts 3022507 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" CDS complement(3022718..3023275) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" gene complement(3022718..3023275) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" misc_feature 3022739..3022758 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3022749 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" downshifts complement(3022759) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" S_feature 3022771..3023452 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(3023301..3023320) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023309) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" promotor_-35 complement(3023336..3023340) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3023453..3025054 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" gene 3023453..3025054 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" CDS 3025047..3025754 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" gene 3025047..3025754 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" downshifts 3025739 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" promotor_-35 3025918..3025925 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3025936..3026225 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 3025936 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" promotor_-10 3025940..3025959 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3026226..3027305 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" gene 3026226..3027305 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" CDS 3027381..3028913 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" gene 3027381..3028913 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" CDS 3028906..3029952 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" gene 3028906..3029952 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" CDS 3029953..3030912 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" gene 3029953..3030912 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" S_feature 3030913..3031034 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 3031007..3031010 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3031025..3031044 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3031036 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" CDS 3031066..3032412 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" gene 3031066..3032412 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" downshifts 3032395 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" CDS complement(3032448..3032663) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" gene complement(3032448..3032663) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" promotor_-35 3032603..3032609 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032623..3032634 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032627 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3032674..3032692) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032681) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" promotor_-35 3032706..3032713 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3032708..3032713) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3032728..3032823 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 3032728..3032747 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032728 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" promotor_-35 3032786..3032790 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032806..3032825 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3032825..3032974 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 3032825 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3032894..3035299 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" gene 3032894..3035299 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" CDS 3035292..3035723 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" gene 3035292..3035723 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" CDS 3035723..3036064 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" gene 3035723..3036064 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" promotor_no_box 3035955..3036055 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3036015 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3036057..3037538 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" gene 3036057..3037538 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" S_feature complement(3036790..3038658) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 3037544..3038020 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" gene 3037544..3038020 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" CDS 3038020..3038304 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" gene 3038020..3038304 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" CDS 3038288..3038662 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" gene 3038288..3038662 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" downshifts 3038633 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" CDS complement(3038701..3039081) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" gene complement(3038701..3039081) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" downshifts complement(3038703) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" CDS complement(3039100..3039744) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" gene complement(3039100..3039744) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" S_feature complement(3039745..3039824) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(3039825..3042134) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" gene complement(3039825..3042134) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" promotor_-35 3040819..3040826 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3040840..3040859 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3040855 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 3041728..3042700 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 3041728 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" misc_feature 3041740..3041756 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3042149..3042316) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" gene complement(3042149..3042316) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" CDS complement(3042304..3043203) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKELIKECLLSYTKGDTRCKT*" gene complement(3042304..3043203) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" S_feature complement(3043204..3043317) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(3043311..3043330) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043317) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" promotor_-35 complement(3043344..3043350) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043388..3043528) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" gene complement(3043388..3043528) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" downshifts complement(3043417) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" S_feature complement(3043529..3043615) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(3043599..3043618) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043615) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" promotor_-35 complement(3043632..3043638) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3043715..3043733) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043725) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3043748..3043754) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3043750..3043875 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" gene 3043750..3043875 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" S_feature complement(3043903..3044332) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 3043928..3043933 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3043945) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" promotor_-10 3043948..3043966 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3043950 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" CDS 3043989..3044357 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" gene 3043989..3044357 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" CDS complement(3044333..3045562) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" gene complement(3044333..3045562) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" S_feature 3044358..3045671 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(3045597..3045616) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045616) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" downshifts 3045629 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3045631..3045638) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3045699..3047171) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" gene complement(3045699..3047171) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" downshifts complement(3045709) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" misc_feature 3047052..3047056 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3047059 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3047169 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" CDS complement(3047187..3047738) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" gene complement(3047187..3047738) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" promotor_-10 complement(3047760..3047779) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047773) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3047792..3047799) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3047835..3048233) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" gene complement(3047835..3048233) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" S_feature complement(3048234..3048304) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(3048305..3048553) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" gene complement(3048305..3048553) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" promotor_-10 complement(3048576..3048595) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048587) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3048611..3048614) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048626..3048847) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" gene complement(3048626..3048847) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" downshifts complement(3048653) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" downshifts 3048841 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(3048865..3048884) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048871) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" promotor_-35 complement(3048897..3048906) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048907..3050016) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" gene complement(3048907..3050016) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" promotor_-35 3049668..3049675 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049690..3049709 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3049699..3050093 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 3049699 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" promotor_-10 complement(3050064..3050083) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(3050080) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" S_feature complement(3050082..3050522) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 3050085..3050087 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3050095 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3050097..3050102) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 3050103..3050122 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3050131..3050520 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" gene 3050131..3050520 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" CDS complement(3050561..3050797) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" gene complement(3050561..3050797) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" downshifts complement(3050567) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3050817..3050836) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050831) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" S_feature complement(3050833..3050973) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(3050850..3050859) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3050974..3051504) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" gene complement(3050974..3051504) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" promotor_-10 complement(3051524..3051543) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(3051535) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" S_feature complement(3051537..3051623) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(3051555..3051563) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(3051618..3051637) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051625) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" promotor_-35 complement(3051651..3051660) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3051702..3052433) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" gene complement(3051702..3052433) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" downshifts complement(3051732) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(3052448..3052467) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052459) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" promotor_-35 complement(3052482..3052489) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3052496..3052951) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" gene complement(3052496..3052951) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" promotor_-35 3052904..3052910 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052925..3052943 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3052933..3055300 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 3052933 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" CDS complement(3052983..3056213) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" gene complement(3052983..3056213) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" CDS complement(3056210..3060697) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" gene complement(3056210..3060697) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" promotor_-35 3059972..3059978 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059993..3060011 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3059999..3060961 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 3059999 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" CDS complement(3060758..3062113) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" gene complement(3060758..3062113) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" downshifts complement(3060779) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" CDS complement(3062128..3062367) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" gene complement(3062128..3062367) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" CDS complement(3062437..3062730) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" gene complement(3062437..3062730) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" downshifts complement(3062447) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" downshifts 3062724 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" S_feature complement(3062731..3062809) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 3062772..3062779 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3062789..3062808) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3062790 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" promotor_-10 3062794..3062811 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3062809) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" promotor_-35 complement(3062823..3062830) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3062868..3062873 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3062888..3062907 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3062900..3063006 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 3062900 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" promotor_-35 3063075..3063081 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3063095..3063114 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3063098 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3063203..3063206 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 3063215 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" promotor_-10 complement(3063218..3063237) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3063222..3063241 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(3063240) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3063251..3064519 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" gene 3063251..3064519 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" promotor_-35 complement(3063252..3063259) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3064579..3064598 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3064584 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" CDS 3064621..3065757 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" gene 3064621..3065757 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" downshifts 3065757 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" promotor_-35 3065806..3065814 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3065824 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" promotor_-10 3065826..3065844 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3065869..3066546 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" gene 3065869..3066546 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" downshifts 3066530 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" CDS complement(3066590..3066799) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" gene complement(3066590..3066799) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" downshifts complement(3066602) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" CDS complement(3066815..3073951) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" gene complement(3066815..3073951) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" CDS complement(3073971..3074909) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" gene complement(3073971..3074909) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" CDS complement(3074937..3076556) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" gene complement(3074937..3076556) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" CDS complement(3076585..3077781) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" gene complement(3076585..3077781) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" promotor_-35 3077629..3077636 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077651..3077670 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3077658 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3077807..3078592) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" gene complement(3077807..3078592) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" S_feature complement(3078593..3078702) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(3078697..3078716) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3078702) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" S_feature complement(3078704..3078785) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(3078730..3078737) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3078786..3079655) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" gene complement(3078786..3079655) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" S_feature complement(3079656..3079736) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(3079720..3079739) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079736) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" promotor_-35 complement(3079753..3079760) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3079869..3080465) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" gene complement(3079869..3080465) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" S_feature complement(3080466..3080550) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 3080501..3080508 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3080518 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" promotor_-10 3080523..3080542 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3080544..3080558) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3080550) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" promotor_-35 complement(3080566..3080570) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3080566..3081168 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" gene 3080566..3081168 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" downshifts 3081154 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" CDS complement(3081238..3082566) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" gene complement(3081238..3082566) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" downshifts complement(3081254) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(3082620..3082639) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082623) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" promotor_-35 complement(3082654..3082661) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3082713..3084215) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" gene complement(3082713..3084215) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" downshifts complement(3082728) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" misc_feature 3083780..3083794 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3083796 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3084216..3084290) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 3084238..3084245 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084256..3084275 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3084258..3084372 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 3084258 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" misc_feature complement(3084285..3084304) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3084295) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" CDS 3084373..3084849 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" gene 3084373..3084849 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" downshifts 3084798 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" CDS complement(3084880..3085536) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" gene complement(3084880..3085536) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" downshifts complement(3084908) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3085184..3085193 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3085207..3085226 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085224 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" S_feature 3085226..3085672 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(3085550) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" promotor_-10 complement(3085552..3085563) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3085578..3085584) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3085629 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" CDS complement(3085640..3085960) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" gene complement(3085640..3085960) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" downshifts complement(3085654) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" S_feature 3085674..3085884 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 3085826..3085926 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3085886..3085995 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 3085886 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" downshifts 3085952 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3085979..3085998) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085984) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" S_feature 3085997..3086548 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(3086013..3086020) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3086014..3086157) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" gene complement(3086014..3086157) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" promotor_-10 complement(3086181..3086200) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086202) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" promotor_-35 complement(3086216..3086219) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3086330..3087550) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" gene complement(3086330..3087550) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" downshifts complement(3086358) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" S_feature complement(3087551..3087678) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(3087678) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" S_feature complement(3087680..3087744) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(3087680..3087698) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3087714..3087719) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3087735..3087754) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087743) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" promotor_-35 complement(3087769..3087776) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3087818..3087825 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087837..3087856 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087837 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" CDS 3087882..3088880 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" gene 3087882..3088880 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" promotor_-10 complement(3087905..3087923) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087920) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3087940..3087945) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3088856 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" CDS complement(3088919..3089059) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" gene complement(3088919..3089059) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" downshifts complement(3088931) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" S_feature complement(3089060..3089189) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(3089170..3089189) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089189) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" S_feature complement(3089191..3089438) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(3089203..3089209) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3089246..3089253 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089267..3089286 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089275 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" CDS 3089338..3090318 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" gene 3089338..3090318 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" upshifts complement(3089439) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" promotor_-10 complement(3089443..3089454) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3089468..3089474) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3090286 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" downshifts complement(3090391) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" CDS complement(3090392..3091015) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" gene complement(3090392..3091015) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" CDS complement(3091039..3091557) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" gene complement(3091039..3091557) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" misc_feature complement(3091604..3091623) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3091616) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3091618..3091726) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(3091713..3091730) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091724) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" promotor_-35 complement(3091745..3091752) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3091880) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" CDS complement(3091895..3092257) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" gene complement(3091895..3092257) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" promotor_-10 complement(3092288..3092307) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092298) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3092321..3092328) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092336..3093190) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" gene complement(3092336..3093190) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" promotor_-10 complement(3092906..3092925) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092914) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3092938..3092947) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3093212..3093231) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093226) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" promotor_-35 complement(3093246..3093249) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3093313..3094527) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" gene complement(3093313..3094527) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" promotor_-35 3093862..3093868 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3093883..3093901 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3093890 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" S_feature 3093894..3094663 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(3094564..3094583) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(3094569) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" promotor_-35 complement(3094598..3094605) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 3094620 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" CDS complement(3094664..3094900) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" gene complement(3094664..3094900) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" S_feature 3094665..3095081 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(3094682) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(3094865..3094866) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3094870..3094874) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3094872) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-10 complement(3094915..3094934) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3094916) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-35 complement(3094948..3094955) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3095058..3095063 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3095077..3095096 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3095083 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" CDS 3095163..3096230 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" gene 3095163..3096230 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" downshifts 3096214 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" CDS complement(3096256..3096582) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" gene complement(3096256..3096582) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" downshifts complement(3096279) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3096614..3096633) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096631) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" promotor_-35 complement(3096646..3096653) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3096666..3096670 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3096682..3097017 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" gene 3096682..3097017 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" promotor_-10 3096683..3096702 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096688 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" downshifts complement(3096807) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" downshifts 3096995 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" CDS complement(3097059..3099032) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" gene complement(3097059..3099032) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" downshifts complement(3097071) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3099047..3099065) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099070) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" promotor_-35 complement(3099077..3099085) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3099140..3100069) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" gene complement(3099140..3100069) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" downshifts complement(3099153) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" CDS complement(3100066..3101124) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" gene complement(3100066..3101124) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" CDS complement(3101124..3102425) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" gene complement(3101124..3102425) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" promotor_-35 3102310..3102319 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102334..3102353 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102341 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3102426..3102507) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(3102492..3102511) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3102507) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" S_feature complement(3102509..3102625) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(3102526..3102533) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3102626..3103645) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" gene complement(3102626..3103645) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" promotor_-35 3103453..3103458 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3103474..3103492 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103478 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3103668..3103686) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103675) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" promotor_-35 3103684..3103689 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3103702..3103707) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3103705..3103769 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 3103705..3103723 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103705 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" promotor_-35 3103742..3103751 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3103764..3103783 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103771 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" CDS 3103798..3104298 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" gene 3103798..3104298 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" CDS complement(3104325..3105095) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" gene complement(3104325..3105095) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" downshifts complement(3104353) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" CDS complement(3105124..3105558) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" gene complement(3105124..3105558) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" CDS complement(3105582..3105857) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" gene complement(3105582..3105857) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" promotor_-10 complement(3105877..3105896) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105902) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" S_feature complement(3105904..3106596) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(3105910..3105917) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3105920..3105926 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105941..3105952 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105949 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" CDS 3105972..3106604 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" gene 3105972..3106604 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" downshifts 3106565 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" CDS complement(3106620..3107516) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" gene complement(3106620..3107516) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" downshifts complement(3106641) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" S_feature complement(3107517..3107651) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(3107638..3107657) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(3107651) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" promotor_-35 complement(3107673..3107677) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 3107691..3107697 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3107711..3107722 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3107723 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" CDS 3107751..3108731 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" gene 3107751..3108731 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" upshifts complement(3107829) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3107843..3107862) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3107879..3107882) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3108723 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" CDS complement(3108759..3109523) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" gene complement(3108759..3109523) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" downshifts complement(3108775) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3109537..3109555) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109545) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" promotor_-35 complement(3109571..3109576) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3109596..3109901) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " gene complement(3109596..3109901) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" downshifts complement(3109604) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" promotor_-10 complement(3109915..3109934) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109938) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3109948..3109956) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3109966..3111354) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" gene complement(3109966..3111354) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" CDS complement(3111374..3112195) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" gene complement(3111374..3112195) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" CDS complement(3112213..3113061) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" gene complement(3112213..3113061) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" promotor_-35 3112580..3112585 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3112601..3112619 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3112615 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3113072..3113091) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3113087) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" CDS complement(3113099..3113446) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" gene complement(3113099..3113446) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" promotor_-10 complement(3113459..3113478) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113478) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3113492..3113498) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3113543..3114883) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" gene complement(3113543..3114883) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" downshifts complement(3113571) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" downshifts complement(3114627) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" promotor_-35 3114940..3114946 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3114960..3114979 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3114962..3114980) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3114968 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" S_feature 3114969..3115057 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(3114979) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3114996..3115001) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3115058..3116653 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" gene 3115058..3116653 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" CDS 3116798..3118147 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " gene 3116798..3118147 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" CDS 3118153..3119445 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" gene 3118153..3119445 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" CDS 3119458..3120942 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" gene 3119458..3120942 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" CDS 3120942..3121286 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" gene 3120942..3121286 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" promotor_-35 3121008..3121011 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121029..3121048 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3121041 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3121261 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" S_feature complement(3121302..3121689) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 3121649..3121658 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121671..3121690 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3121674 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" ncRNA complement(3121710..3121841) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" CDS 3121710..3121841 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " gene 3121710..3121841 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" gene complement(3121710..3121841) /gene="auzJ" /locus_tag="BSU_ncRNA_2" S_feature 3121842..3121910 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 3121877 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" CDS complement(3122047..3122568) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" gene complement(3122047..3122568) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" CDS complement(3122559..3124796) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" gene complement(3122559..3124796) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" CDS complement(3124797..3125630) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" gene complement(3124797..3125630) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" CDS complement(3125627..3126244) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" gene complement(3125627..3126244) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" downshifts complement(3125736) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" CDS complement(3126241..3127233) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" gene complement(3126241..3127233) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" S_feature complement(3127234..3127320) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3127298..3127317) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127320) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" promotor_-35 complement(3127331..3127336) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127462..3128712) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" gene complement(3127462..3128712) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" CDS complement(3128729..3129967) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" gene complement(3128729..3129967) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" CDS 3130190..3130327 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" gene 3130190..3130327 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" promotor_-35 3130349..3130352 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130367..3130386 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130368 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" CDS 3130409..3131275 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" gene 3130409..3131275 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" downshifts 3131278 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" CDS complement(3131309..3132412) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" gene complement(3131309..3132412) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" downshifts complement(3131324) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" S_feature complement(3132413..3133346) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3132450..3132457 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3132471..3132490 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3132481 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-35 3132532..3132538 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3132549 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-10 3132553..3132572 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3132594..3133322 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" gene 3132594..3133322 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" CDS complement(3133347..3134201) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" gene complement(3133347..3134201) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" misc_feature complement(3133534..3133553) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3133546) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" promotor_no_box complement(3133704..3133804) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3133744) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" CDS complement(3134215..3135117) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" gene complement(3134215..3135117) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" CDS complement(3135121..3135999) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" gene complement(3135121..3135999) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" CDS complement(3136057..3137325) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" gene complement(3136057..3137325) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" promotor_no_box 3137216..3137316 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3137276 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(3137396) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" CDS complement(3137406..3138392) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" gene complement(3137406..3138392) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" upshifts 3138339 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3138342..3138346 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3138435..3138454) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138448) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" promotor_-35 complement(3138469..3138476) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3138606) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" CDS complement(3138608..3138982) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" gene complement(3138608..3138982) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" upshifts complement(3139046) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" promotor_-10 complement(3139053..3139064) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3139078..3139084) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3139085..3140203) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" gene complement(3139085..3140203) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" promotor_-10 complement(3140228..3140247) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140234) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" S_feature complement(3140236..3140846) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3140261..3140267) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3140300..3140309 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140323..3140342 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140327 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" promotor_-10 complement(3140340..3140355) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140344) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3140362..3140366) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3140362..3140508 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" gene 3140362..3140508 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" CDS 3140508..3140783 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" gene 3140508..3140783 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" upshifts complement(3140652) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3140668..3140682) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3140691..3140695) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3140763 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" CDS complement(3140847..3141230) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" gene complement(3140847..3141230) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" S_feature complement(3141231..3141340) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3141341..3141619) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" gene complement(3141341..3141619) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" promotor_-10 complement(3141617..3141636) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141641) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3141651..3141658) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3141782..3141888) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3141825) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" CDS complement(3141889..3143286) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" gene complement(3141889..3143286) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" downshifts 3143084 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" CDS complement(3143307..3143750) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" gene complement(3143307..3143750) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" CDS complement(3143740..3144960) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" gene complement(3143740..3144960) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" CDS complement(3144960..3146273) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" gene complement(3144960..3146273) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" CDS complement(3146291..3147076) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" gene complement(3146291..3147076) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" promotor_-10 complement(3147120..3147139) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3147121) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" promotor_-35 complement(3147153..3147160) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3147177..3147196) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3147186) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" S_feature complement(3147188..3147269) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3147212..3147216) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3147233..3147480) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" gene complement(3147233..3147480) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" CDS complement(3147270..3147407) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" gene complement(3147270..3147407) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" S_feature complement(3147408..3147492) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3147476..3147495) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147492) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" S_feature complement(3147494..3147600) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3147511..3147514) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3147601..3147978) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" gene complement(3147601..3147978) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" promotor_-10 complement(3147995..3148006) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3148001) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" promotor_-35 complement(3148020..3148026) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3148063..3148887) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" gene complement(3148063..3148887) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" downshifts complement(3148071) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3148220) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" promotor_-35 3148247..3148252 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148268..3148286 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148270 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3148901..3149569) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" gene complement(3148901..3149569) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" CDS complement(3149562..3150587) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" gene complement(3149562..3150587) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" S_feature complement(3150588..3150692) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3150693..3150799) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(3150693..3150799) /gene="mswH" /locus_tag="BSU_misc_RNA_53" downshifts 3150762 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" promotor_-10 complement(3150826..3150845) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150838) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" S_feature complement(3150840..3150913) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3150861..3150868) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3150914..3151258) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" gene complement(3150914..3151258) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" S_feature complement(3151259..3151364) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3151365..3151685) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" gene complement(3151365..3151685) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" CDS complement(3151687..3152127) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" gene complement(3151687..3152127) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" CDS complement(3152127..3152363) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" gene complement(3152127..3152363) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" downshifts complement(3152139) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" upshifts complement(3152378) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" promotor_-10 complement(3152383..3152394) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3152409..3152415) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3152419..3152802) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" gene complement(3152419..3152802) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" promotor_-10 complement(3152829..3152848) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3152840) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" promotor_-35 complement(3152861..3152868) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3152869..3153225) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" gene complement(3152869..3153225) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" promotor_-10 complement(3153248..3153267) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3153258) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" promotor_-35 complement(3153281..3153286) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3153336..3155120) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" gene complement(3153336..3155120) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" downshifts complement(3153346) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" CDS complement(3155135..3156310) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " gene complement(3155135..3156310) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" CDS complement(3156321..3158690) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" gene complement(3156321..3158690) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" promotor_-35 3158109..3158114 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158129..3158147 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3158132 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3158758..3158777) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3158761) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" S_feature complement(3158769..3159035) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3158791..3158798) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3158816..3158822 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158837..3158848 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3158859 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" CDS 3158865..3159011 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" gene 3158865..3159011 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" S_feature 3159012..3160038 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3159036..3159944) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" gene complement(3159036..3159944) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" S_feature complement(3159945..3160467) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3160039..3160284 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" gene 3160039..3160284 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" CDS 3160297..3160629 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" gene 3160297..3160629 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" promotor_-10 complement(3160450..3160469) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160467) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" promotor_-35 complement(3160483..3160492) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3160618 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" promotor_-35 3160690..3160697 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3160711..3160730 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3160722 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" CDS 3160788..3161255 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" gene 3160788..3161255 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" CDS 3161252..3162877 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" gene 3161252..3162877 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" downshifts 3162862 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" CDS complement(3162913..3163296) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" gene complement(3162913..3163296) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" CDS complement(3163315..3163704) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" gene complement(3163315..3163704) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" CDS complement(3163726..3164055) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" gene complement(3163726..3164055) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" promotor_-10 complement(3164090..3164109) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3164097..3164104 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3164104) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3164119..3164138 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3164123..3164130) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3164129 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" CDS 3164189..3165076 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" gene 3164189..3165076 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" CDS complement(3165096..3165383) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" gene complement(3165096..3165383) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" downshifts complement(3165108) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" CDS complement(3165408..3166235) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " gene complement(3165408..3166235) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" downshifts complement(3165424) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" S_feature complement(3166236..3166373) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3166358..3166377) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166373) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" promotor_-35 complement(3166393..3166396) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3166453..3166890) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" gene complement(3166453..3166890) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" promotor_-10 complement(3166914..3166932) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3166920) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" promotor_-35 complement(3166948..3166953) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3167000..3168508) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" gene complement(3167000..3168508) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo downshifts complement(3167021) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" CDS complement(3168499..3168795) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" gene complement(3168499..3168795) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo promotor_-10 complement(3168818..3168837) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168834) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" promotor_-35 complement(3168852..3168855) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3168872..3168877 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3168889..3168908 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3168889 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" CDS 3168929..3169771 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" gene 3168929..3169771 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" promotor_-35 3169301..3169307 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3169322..3169333 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3169330 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" promotor_-35 3169798..3169805 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3169814 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" promotor_-10 3169817..3169836 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3169861..3170322 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" gene 3169861..3170322 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" downshifts 3170298 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" CDS complement(3170366..3171742) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" gene complement(3170366..3171742) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" downshifts complement(3170374) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3171743..3171914) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3171895..3171914) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171914) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" promotor_-35 complement(3171925..3171932) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3171975..3171994) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3171985..3172004 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3171987 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" upshifts complement(3171993) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" S_feature complement(3171995..3173058) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3172009..3172016) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3172020..3172697 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" gene 3172020..3172697 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" CDS 3172694..3174049 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" gene 3172694..3174049 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" S_feature complement(3173148..3174076) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3174017 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" CDS complement(3174077..3174241) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" gene complement(3174077..3174241) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" promotor_-35 3174265..3174272 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174286..3174305 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3174290..3174309) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3174296..3174408 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3174296 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" upshifts complement(3174303) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3174305..3174583) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3174323..3174330) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3174409..3175284 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" gene 3174409..3175284 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" promotor_-10 complement(3174573..3174592) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174583) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3174585..3175126) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3174606..3174613) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3175118..3175136) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175126) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3175128..3175257) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3175149..3175156) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3175259 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" downshifts complement(3175302) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3175320..3176708) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" gene complement(3175320..3176708) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" upshifts complement(3176732) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 complement(3176737..3176755) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3176766..3176774) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3176775..3176960) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" gene complement(3176775..3176960) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" downshifts 3176964 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(3177004..3177023) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3177013..3177019 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3177018) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 3177033..3177044 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3177036 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" promotor_-35 complement(3177039..3177042) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3177078..3178526 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" gene 3177078..3178526 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" S_feature complement(3178074..3180717) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3178495..3179592 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" gene 3178495..3179592 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" CDS 3179589..3180710 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" gene 3179589..3180710 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" CDS complement(3180718..3181353) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" gene complement(3180718..3181353) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" CDS complement(3181331..3182413) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" gene complement(3181331..3182413) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" CDS complement(3182410..3183135) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" gene complement(3182410..3183135) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" CDS complement(3183169..3184041) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" gene complement(3183169..3184041) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" promotor_-10 complement(3184060..3184079) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184080) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" promotor_-35 complement(3184094..3184097) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3184142..3184819) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" gene complement(3184142..3184819) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" downshifts complement(3184158) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" CDS complement(3184846..3185226) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" gene complement(3184846..3185226) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" promotor_-10 complement(3185249..3185268) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3185269) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" promotor_-35 complement(3185283..3185286) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185388..3186656) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" gene complement(3185388..3186656) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" downshifts complement(3185401) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3186690..3186709) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186701) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" promotor_-35 complement(3186724..3186731) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3186827) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" CDS complement(3186833..3187414) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" gene complement(3186833..3187414) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" CDS complement(3187437..3188765) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" gene complement(3187437..3188765) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" CDS complement(3188765..3189826) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" gene complement(3188765..3189826) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" CDS complement(3189789..3190733) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" gene complement(3189789..3190733) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" S_feature complement(3190734..3191003) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3190842..3190972) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" gene complement(3190842..3190972) /gene="srbL" /locus_tag="BSU_misc_RNA_85" promotor_-10 complement(3190980..3190999) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3191003) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" S_feature complement(3191005..3191932) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3191015..3191022) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3191065..3191072 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3191087..3191106 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191091 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" CDS 3191131..3191922 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" gene 3191131..3191922 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" downshifts 3191793 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" downshifts 3191903 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" CDS complement(3191960..3192838) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" gene complement(3191960..3192838) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" downshifts complement(3191977) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3192862..3192880) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192881) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" promotor_-35 complement(3192894..3192900) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3192910..3194652) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" gene complement(3192910..3194652) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" CDS complement(3194649..3195362) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" gene complement(3194649..3195362) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" misc_feature complement(3195393..3195412) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3195411) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" CDS complement(3195515..3195754) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" gene complement(3195515..3195754) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" downshifts complement(3195522) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3195750..3195768) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3195758..3196288) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" gene complement(3195758..3196288) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" upshifts complement(3195759) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3195783..3195789) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3196291..3196310) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196298) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" CDS 3196303..3196641 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" gene 3196303..3196641 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" promotor_-35 complement(3196325..3196332) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3196341..3196360) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196353) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3196375..3196381) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3196387..3196487 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3196447 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" promotor_no_box 3196615..3196715 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3196675..3196761 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3196675 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" CDS 3196762..3197919 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" gene 3196762..3197919 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" downshifts 3197905 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" CDS 3197980..3198390 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" gene 3197980..3198390 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" downshifts 3198389 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" CDS complement(3198424..3199653) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" gene complement(3198424..3199653) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" downshifts complement(3198441) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" CDS complement(3199646..3200335) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" gene complement(3199646..3200335) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" CDS complement(3200319..3201512) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" gene complement(3200319..3201512) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" promotor_-10 complement(3201556..3201575) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201569) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" promotor_-35 complement(3201590..3201597) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3201683..3202492) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" gene complement(3201683..3202492) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" downshifts complement(3201700) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3201839..3201848 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201861..3201880 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201865 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3202508..3203518) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" gene complement(3202508..3203518) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" CDS complement(3203518..3204672) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" gene complement(3203518..3204672) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" promotor_-10 complement(3204605..3204624) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3204622) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" promotor_-35 complement(3204636..3204643) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3204684..3204691 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204706..3204725 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204715 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" CDS 3204770..3205717 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" gene 3204770..3205717 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" downshifts 3205693 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" downshifts 3205737 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" downshifts 3205891 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" CDS complement(3205952..3207361) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" gene complement(3205952..3207361) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" downshifts complement(3205967) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" promotor_-35 3206779..3206783 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3206801..3206817 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3206808 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" S_feature 3206815..3207782 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3207463) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" misc_RNA complement(3207465..3207644) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" gene complement(3207465..3207644) /gene="kswB" /locus_tag="BSU_misc_RNA_54" promotor_-10 complement(3207674..3207691) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207685) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" promotor_-35 complement(3207706..3207713) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3207739 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" CDS complement(3207761..3207901) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" gene complement(3207761..3207901) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" downshifts complement(3207771) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" upshifts complement(3207929) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" S_feature complement(3207931..3208519) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3207934..3207945) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3207959..3207965) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3207991..3207998 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3208012 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" promotor_-10 3208014..3208033 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3208068..3208550 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" gene 3208068..3208550 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" promotor_-35 3208564..3208571 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3208585..3208604 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3208597 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" CDS 3208650..3210503 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" gene 3208650..3210503 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" downshifts 3210489 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" CDS complement(3210531..3211457) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" gene complement(3210531..3211457) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" downshifts complement(3210543) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3211469..3211488) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211490) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" promotor_-35 complement(3211504..3211507) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3211526..3211545 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3211535 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" CDS 3211568..3212350 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" gene 3211568..3212350 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" CDS 3212322..3213014 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" gene 3212322..3213014 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" downshifts 3213006 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" CDS complement(3213045..3213875) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" gene complement(3213045..3213875) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" downshifts complement(3213051) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" promotor_-35 3213738..3213742 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213758..3213762 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213767 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3213877 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" promotor_-10 complement(3213905..3213924) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3213923) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" promotor_-35 complement(3213939..3213946) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3214031..3214037 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3214051 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" promotor_-10 3214052..3214070 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3214098..3214583 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" gene 3214098..3214583 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" downshifts 3214582 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" CDS complement(3214627..3216639) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" gene complement(3214627..3216639) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" downshifts complement(3214635) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3216305..3216309) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3216307) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3216640..3216791) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3216768..3216786) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3216791) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" CDS complement(3216894..3218609) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" gene complement(3216894..3218609) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" downshifts complement(3216901) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" CDS complement(3218635..3220452) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" gene complement(3218635..3220452) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" promotor_-10 complement(3220494..3220513) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3220503..3220510 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3220513) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" upshifts 3220516 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3220523..3220542 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3220526..3220533) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3220623..3222947) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" gene complement(3220623..3222947) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" downshifts complement(3220641) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" promotor_-35 3222967..3222974 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222989..3223008 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3222990..3223005) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3222993 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3222995) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-10 complement(3223040..3223059) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223049) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3223075..3223081) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3223085..3223104) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223105) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3223118..3223126) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3223132) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" CDS complement(3223145..3223753) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" gene complement(3223145..3223753) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" promotor_-10 complement(3223792..3223811) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223809) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" promotor_-35 complement(3223827..3223831) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3223940..3224356) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" gene complement(3223940..3224356) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" downshifts complement(3223950) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" CDS complement(3224361..3225029) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" gene complement(3224361..3225029) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" promotor_-10 complement(3225081..3225100) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225096) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" downshifts complement(3225107) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3225114..3225119) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3225149..3227257) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" gene complement(3225149..3227257) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" S_feature complement(3227249..3227350) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3227344..3227363) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227350) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" promotor_-35 complement(3227379..3227386) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3227417..3229825) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" gene complement(3227417..3229825) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" downshifts complement(3227439) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" downshifts complement(3227505) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3229826..3229908) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3229909..3230118) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" gene complement(3229909..3230118) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" promotor_-10 complement(3230142..3230161) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3230163) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" promotor_-35 complement(3230174..3230180) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3230192..3230497) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " gene complement(3230192..3230497) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" misc_feature 3230461..3230480 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3230472 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3230511..3230530) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3230537) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" promotor_-35 complement(3230544..3230550) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3230589..3230595 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3230610..3230628 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3230618 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" CDS 3230625..3231701 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" gene 3230625..3231701 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" downshifts 3231688 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" CDS complement(3231738..3232373) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" gene complement(3231738..3232373) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" downshifts complement(3231751) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" S_feature complement(3232374..3232471) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3232451..3232470) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232471) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" promotor_-35 complement(3232484..3232490) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3232533..3234428) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" gene complement(3232533..3234428) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" promotor_-10 complement(3234479..3234490) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234479) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3234505..3234511) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3234578) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" CDS complement(3234591..3234992) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" gene complement(3234591..3234992) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" CDS complement(3234989..3235348) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" gene complement(3234989..3235348) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" CDS complement(3235345..3235917) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" gene complement(3235345..3235917) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" promotor_-10 complement(3235955..3235974) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235960) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" promotor_-35 complement(3235988..3235995) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3236028..3236822) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" gene complement(3236028..3236822) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" promotor_-10 complement(3236843..3236861) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236855) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" promotor_-35 complement(3236876..3236882) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3236888..3236907) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236899) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" S_feature complement(3236901..3236966) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3236921..3236928) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3237008..3237367) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" gene complement(3237008..3237367) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" downshifts complement(3237011) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3237351..3237359) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237361) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" promotor_-35 complement(3237374..3237379) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3237419..3237438) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237427) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" S_feature complement(3237429..3237493) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3237451..3237455) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3237493) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" promotor_-10 complement(3237494..3237513) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3237528..3237535) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3237544..3238014) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" gene complement(3237544..3238014) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" promotor_no_box 3237841..3237941 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3237901 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3238011 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3238059..3238078) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3238065) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" S_feature complement(3238067..3238158) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3238094..3238097) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3238159..3240498) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" gene complement(3238159..3240498) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" promotor_-35 3239259..3239262 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3239278..3239281 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239287 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3240517..3241257) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" gene complement(3240517..3241257) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" promotor_-10 complement(3240913..3240931) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3240925) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" promotor_-35 complement(3240946..3240952) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3241285..3241303) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3241299) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" downshifts complement(3241387) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" CDS complement(3241389..3241619) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" gene complement(3241389..3241619) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" promotor_-10 complement(3241649..3241668) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3241670) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" promotor_-35 complement(3241683..3241686) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3241708..3241714 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241728..3241739 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241729 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" CDS 3241768..3242538 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" gene 3241768..3242538 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" promotor_-35 3241790..3241798 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241809..3241827 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241839 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3242578..3242811) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" gene complement(3242578..3242811) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" promotor_-35 3242902..3242909 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3242917 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" promotor_-10 3242921..3242940 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3242963..3243370 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" gene 3242963..3243370 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" CDS 3243400..3243819 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" gene 3243400..3243819 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" promotor_-35 3243857..3243864 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3243878..3243897 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3243885 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" CDS 3243911..3244237 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" gene 3243911..3244237 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" S_feature 3244238..3244322 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3244293..3244300 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3244313..3244331 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3244324 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" CDS 3244362..3246062 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" gene 3244362..3246062 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" S_feature complement(3245078..3246071) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3246040 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" CDS complement(3246102..3246782) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" gene complement(3246102..3246782) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" downshifts complement(3246116) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" promotor_-35 3246476..3246482 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3246497..3246515 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3246502..3249253 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3246502 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" CDS complement(3246799..3247719) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" gene complement(3246799..3247719) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" CDS complement(3247731..3248384) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " gene complement(3247731..3248384) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" CDS complement(3248401..3249546) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" gene complement(3248401..3249546) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" S_feature complement(3249547..3249614) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3249614) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" promotor_-10 complement(3249615..3249634) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3249645..3249649 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3249649..3249652) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249665..3249683 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249670 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" promotor_-35 3249765..3249769 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249785..3249804 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249788 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" CDS 3249830..3250363 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" gene 3249830..3250363 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" S_feature complement(3250030..3250549) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3250352 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" promotor_-35 3250486..3250493 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3250506..3250584 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3250506 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" promotor_-10 3250508..3250527 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3250534..3250548) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3250549) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3250558) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3250585..3251061 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" gene 3250585..3251061 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" promotor_-10 complement(3250610..3250629) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3250620) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3250641..3250648) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3251058..3252029 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" gene 3251058..3252029 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" promotor_no_box 3251866..3251966 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3251926 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" promotor_-10 complement(3251938..3251955) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251959) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" S_feature complement(3251961..3252363) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3251972..3251974) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3251990) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" CDS 3252072..3252683 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" gene 3252072..3252683 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" S_feature complement(3252365..3252451) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3252408) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" S_feature complement(3252453..3252638) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3252496) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" downshifts 3252663 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" downshifts complement(3252683) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" S_feature 3252708..3253846 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3252730..3253353) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" gene complement(3252730..3253353) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" downshifts complement(3252738) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" CDS complement(3253350..3253622) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" gene complement(3253350..3253622) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" promotor_-10 complement(3253678..3253697) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253687) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" S_feature complement(3253689..3253837) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3253709..3253715) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3253842..3254531) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" gene complement(3253842..3254531) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" downshifts complement(3253882) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" promotor_-35 3254474..3254482 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3254496..3254515 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3254510 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3254549..3255460) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" gene complement(3254549..3255460) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" CDS complement(3255480..3256133) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " gene complement(3255480..3256133) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" CDS complement(3256156..3257298) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" gene complement(3256156..3257298) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" promotor_-10 complement(3257342..3257361) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3257357) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" promotor_-35 complement(3257376..3257379) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3257495..3257502 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3257515..3257534 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3257526 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" CDS 3257562..3258119 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" gene 3257562..3258119 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" S_feature 3258120..3258884 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3258137..3258772) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" gene complement(3258137..3258772) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" downshifts complement(3258150) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3258813..3258831) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258819) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" promotor_-35 complement(3258847..3258853) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3258858..3258865 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3258877..3258896 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3258886 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" CDS 3258922..3259536 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" gene 3258922..3259536 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" downshifts 3259522 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" promotor_-35 3259590..3259593 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259608..3259627 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3259616 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" CDS 3259668..3260366 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" gene 3259668..3260366 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" downshifts 3260339 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" CDS complement(3260402..3262219) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" gene complement(3260402..3262219) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" downshifts complement(3260421) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3260592) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" misc_feature complement(3262261..3262280) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3262265..3262284 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3262270 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" upshifts complement(3262274) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" CDS 3262339..3262806 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" gene 3262339..3262806 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" downshifts 3262803 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" CDS complement(3262851..3264143) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" gene complement(3262851..3264143) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" downshifts complement(3262861) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" CDS complement(3264173..3265708) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" gene complement(3264173..3265708) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" CDS complement(3265701..3266462) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" gene complement(3265701..3266462) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" CDS complement(3266493..3267677) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" gene complement(3266493..3267677) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" S_feature complement(3267678..3267918) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3267918) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3267920..3267993) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3267932..3267951) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3267967..3267971) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3267994..3269001) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" gene complement(3267994..3269001) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" promotor_-35 3268920..3268923 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268940..3268942 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3268942 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3269048..3270070) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" gene complement(3269048..3270070) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" upshifts complement(3269064) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" promotor_-10 complement(3269072) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3269092..3269093) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3270071..3270182) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3270108 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" promotor_-10 complement(3270163..3270182) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270182) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3270184..3270294) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3270196..3270203) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3270277..3270296) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3270292) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" promotor_-35 complement(3270309..3270318) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3270368..3271762) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" gene complement(3270368..3271762) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" downshifts complement(3270382) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3271861..3271880) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271875) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" promotor_-35 complement(3271895..3271902) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3271902..3271909 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271923..3271942 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3271929 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" CDS 3271966..3273054 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" gene 3271966..3273054 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" downshifts 3273034 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" CDS complement(3273103..3274113) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" gene complement(3273103..3274113) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" downshifts complement(3273110) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" S_feature complement(3274114..3274191) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3274181..3274200) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274191) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" promotor_-35 complement(3274214..3274221) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3274270..3275148) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" gene complement(3274270..3275148) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" promotor_-35 3274806..3274812 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3274827..3274838 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3274838 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3275182..3275189 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3275195..3275214) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3275200) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" promotor_-10 3275203..3275222 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275205 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" promotor_-35 complement(3275228..3275232) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3275248..3276165 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" gene 3275248..3276165 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" downshifts 3276154 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" CDS complement(3276206..3277549) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" gene complement(3276206..3277549) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" misc_RNA complement(3277618..3277853) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" gene complement(3277618..3277853) /gene="tboX" /locus_tag="BSU_misc_RNA_56" downshifts complement(3277752) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3277854..3277950) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3277951..3278985) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" gene complement(3277951..3278985) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" promotor_-10 complement(3279007..3279025) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279013) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" promotor_-35 complement(3279038..3279045) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3279093..3279815) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" gene complement(3279093..3279815) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" downshifts complement(3279109) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" CDS complement(3279815..3281254) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" gene complement(3279815..3281254) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" promotor_-35 3280802..3280805 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3280822 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3280823..3280827 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3280976 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" upshifts 3281130 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3281131..3281132 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3281281..3281997) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" gene complement(3281281..3281997) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" promotor_-35 3281901..3281908 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3281922..3281924 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3281922 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3281995 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" S_feature complement(3281998..3282064) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3282061..3282080) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3282064) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" promotor_-35 complement(3282095..3282102) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3282172..3282774) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" gene complement(3282172..3282774) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" CDS complement(3282791..3283906) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" gene complement(3282791..3283906) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" CDS complement(3283910..3284647) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" gene complement(3283910..3284647) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" promotor_-10 complement(3283936..3283955) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3283950) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" promotor_-35 complement(3283967..3283974) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3284648..3285553) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" gene complement(3284648..3285553) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" promotor_-10 complement(3285573..3285591) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3285584) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3285607..3285610) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3285762..3285769 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3285780..3285799 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3285787 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" CDS 3285837..3286646 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" gene 3285837..3286646 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" CDS 3286682..3287893 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" gene 3286682..3287893 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" downshifts 3287880 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" CDS complement(3287947..3289236) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" gene complement(3287947..3289236) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" CDS complement(3289316..3291379) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" gene complement(3289316..3291379) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" CDS complement(3291398..3292249) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" gene complement(3291398..3292249) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" CDS complement(3292253..3293509) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" gene complement(3292253..3293509) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" CDS complement(3293549..3294814) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" gene complement(3293549..3294814) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" promotor_-10 complement(3294846..3294865) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3294868) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" promotor_-35 complement(3294880..3294887) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3294955..3295947) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" gene complement(3294955..3295947) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" downshifts complement(3294989) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" S_feature complement(3296077..3296126) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3296100) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" CDS complement(3296127..3296786) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" gene complement(3296127..3296786) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" S_feature complement(3296787..3296892) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3296884..3296903) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296893) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" promotor_-35 complement(3296918..3296921) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3296945..3296952 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3296967..3296986 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3296967 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" S_feature 3296970..3297075 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3296976..3296993) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296980) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3297001..3297007) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3297076..3298767 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" gene 3297076..3298767 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" downshifts 3298752 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" CDS complement(3298794..3300104) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" gene complement(3298794..3300104) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" S_feature 3298797..3299867 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3298806) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" misc_feature 3299924..3299943 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3299924..3300182 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3299924 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" promotor_-10 complement(3300118..3300137) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300133) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" promotor_-35 complement(3300152..3300155) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3300183..3300401 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" gene 3300183..3300401 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" downshifts 3300380 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" CDS complement(3300411..3301379) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" gene complement(3300411..3301379) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" CDS complement(3301358..3302524) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" gene complement(3301358..3302524) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" CDS complement(3302529..3303179) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" gene complement(3302529..3303179) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" CDS complement(3303176..3303784) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" gene complement(3303176..3303784) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" CDS complement(3303781..3305298) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" gene complement(3303781..3305298) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" CDS complement(3305295..3306329) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" gene complement(3305295..3306329) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" CDS complement(3306326..3307402) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" gene complement(3306326..3307402) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" CDS complement(3307407..3308441) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" gene complement(3307407..3308441) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" CDS complement(3308466..3309569) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" gene complement(3308466..3309569) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" CDS complement(3309566..3310720) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" gene complement(3309566..3310720) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" CDS complement(3310713..3311549) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" gene complement(3310713..3311549) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" CDS complement(3311546..3312691) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" gene complement(3311546..3312691) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" CDS complement(3312703..3314499) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" gene complement(3312703..3314499) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" S_feature complement(3314500..3314559) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3314533..3314551) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314559) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" promotor_-35 complement(3314565..3314571) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3314758..3315441) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" gene complement(3314758..3315441) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" CDS complement(3315447..3316151) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" gene complement(3315447..3316151) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" promotor_-35 3316116 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3316133 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" promotor_-10 3316136..3316154 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3316152..3316209) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3316205..3316224) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3316210) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" promotor_-35 complement(3316238..3316245) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3316327..3316332 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3316347..3316366 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3316353 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" CDS 3316397..3316855 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" gene 3316397..3316855 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" promotor_-35 3316877..3316880 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3316886 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" promotor_-10 3316897..3316915 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3316931..3318400 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" gene 3316931..3318400 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" downshifts 3318377 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" CDS 3318403..3318594 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" gene 3318403..3318594 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" downshifts 3318573 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" CDS complement(3318621..3319106) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" gene complement(3318621..3319106) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" CDS complement(3319129..3319440) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" gene complement(3319129..3319440) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo CDS complement(3319492..3319584) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" gene complement(3319492..3319584) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo promotor_-10 complement(3319624..3319643) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3319641) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3319657..3319664) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3319715..3320398) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" gene complement(3319715..3320398) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" downshifts complement(3319733) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" CDS complement(3320414..3321769) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" gene complement(3320414..3321769) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" promotor_-10 complement(3321781..3321796) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321797) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3321808..3321817) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3322071..3322078 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3322092..3322111 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3322095 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" S_feature 3322117..3322307 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3322308..3323729 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" gene 3322308..3323729 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" downshifts 3323723 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" CDS 3323803..3325353 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" gene 3323803..3325353 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" promotor_-35 3325397..3325403 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325417..3325428 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3325417 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" CDS 3325461..3327023 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" gene 3325461..3327023 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" downshifts 3327001 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" CDS 3327013..3327702 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" gene 3327013..3327702 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" promotor_-35 3327052..3327059 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3327073..3327092 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3327082 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" downshifts 3327683 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" downshifts complement(3327781) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" CDS 3327784..3328119 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" gene 3327784..3328119 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" CDS 3328119..3328439 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" gene 3328119..3328439 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" S_feature 3328440..3328630 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3328475..3328987) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" gene complement(3328475..3328987) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" downshifts 3328607 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3329023..3329034) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3329029) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3329049..3329055) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3329102..3329238) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3329145) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" CDS complement(3329239..3330582) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" gene complement(3329239..3330582) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" promotor_-10 complement(3330611..3330630) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330619) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3330643..3330652) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3330644..3330649 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330665..3330683 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330668 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3330877..3330886 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3330895 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" promotor_-10 3330900..3330919 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3330938..3331900 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" gene 3330938..3331900 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" S_feature 3331901..3332154 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3332181) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" tRNA complement(3332185..3332260) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3332185..3332260) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" promotor_-10 complement(3332287..3332306) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332308) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" promotor_-35 complement(3332322..3332325) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3332391..3332397 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3332407..3332482 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3332407 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" promotor_-10 3332412..3332431 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3332459..3332466 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3332480..3332499 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3332484 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" CDS 3332530..3333123 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" gene 3332530..3333123 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" downshifts 3333112 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" S_feature 3333157..3333555 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3333169..3333849) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" gene complement(3333169..3333849) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" downshifts complement(3333193) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" CDS complement(3333846..3335531) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" gene complement(3333846..3335531) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" CDS complement(3335524..3337797) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" gene complement(3335524..3337797) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" CDS complement(3337775..3338659) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" gene complement(3337775..3338659) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" CDS complement(3338665..3339501) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" gene complement(3338665..3339501) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" CDS complement(3339502..3340809) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" gene complement(3339502..3340809) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" promotor_-35 3339867..3339876 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339889..3339908 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3339893 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3340849..3342102) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" gene complement(3340849..3342102) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" S_feature complement(3342103..3342197) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3342198..3343967) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" gene complement(3342198..3343967) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" promotor_-35 3343888..3343893 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343909..3343927 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343919 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3344005..3344024) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3344018) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" promotor_-35 complement(3344037..3344044) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3344080..3345030) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" gene complement(3344080..3345030) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" promotor_-10 complement(3345045..3345063) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345058) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3345075..3345083) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3345164) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" CDS complement(3345236..3345811) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" gene complement(3345236..3345811) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" downshifts complement(3345248) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" promotor_-10 complement(3345854..3345873) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3345860..3345867 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3345870) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" upshifts 3345877 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" promotor_-10 3345880..3345899 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3345888..3345895) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3345928..3346248 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" gene 3345928..3346248 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" downshifts 3346229 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" downshifts complement(3346275) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" CDS complement(3346275..3347867) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" gene complement(3346275..3347867) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" CDS complement(3347886..3348479) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" gene complement(3347886..3348479) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" promotor_-10 complement(3348521..3348540) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348534) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" promotor_-35 complement(3348555..3348559) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3348605..3348610 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348626..3348644 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348627 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" promotor_-35 3348800..3348807 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348821..3348840 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348825 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" CDS 3348862..3349839 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" gene 3348862..3349839 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" downshifts 3349811 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" CDS complement(3349877..3351817) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" gene complement(3349877..3351817) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" downshifts complement(3349901) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" CDS complement(3351792..3352571) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" gene complement(3351792..3352571) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" S_feature complement(3352572..3352653) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3352654..3353724) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" gene complement(3352654..3353724) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" CDS complement(3353718..3354431) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" gene complement(3353718..3354431) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" promotor_-10 complement(3354477..3354496) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354489) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3354491..3354752) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3354509..3354512) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3354512..3354519 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354530..3354549 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3354535 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" CDS 3354578..3354787 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" gene 3354578..3354787 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" downshifts 3354765 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" downshifts complement(3354797) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" CDS complement(3354823..3355587) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" gene complement(3354823..3355587) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" downshifts complement(3354845) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" CDS complement(3355588..3355845) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" gene complement(3355588..3355845) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" CDS complement(3355869..3356819) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" gene complement(3355869..3356819) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" CDS complement(3356842..3357795) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" gene complement(3356842..3357795) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" CDS complement(3357797..3358684) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" gene complement(3357797..3358684) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" CDS complement(3358709..3359185) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" gene complement(3358709..3359185) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" promotor_-10 complement(3359205..3359224) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359219) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" promotor_-35 complement(3359240..3359244) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3359263..3359282) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359276) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" promotor_-35 complement(3359297..3359300) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3359352..3359502) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3359395) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" CDS complement(3359503..3360453) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" gene complement(3359503..3360453) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" S_feature complement(3360454..3360541) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3360530..3360549) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3360541) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3360543..3360634) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3360564..3360567) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3360582..3360588 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3360602..3360620 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3360616 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" S_feature 3360617..3364003 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3360659..3362080) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" gene complement(3360659..3362080) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" downshifts complement(3360679) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" downshifts complement(3360803) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" misc_feature 3361707..3361711 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3361717 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3361996..3362000 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3362003 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3362081..3362278) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3362201 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3362266..3362285) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3362278) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" promotor_-35 complement(3362297..3362304) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3362461..3363915) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" gene complement(3362461..3363915) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" downshifts complement(3362481) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" S_feature complement(3363916..3364040) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3363961 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" CDS complement(3364041..3365810) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" gene complement(3364041..3365810) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" S_feature complement(3365811..3365885) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3365874..3365893) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3365885) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" CDS complement(3365975..3366334) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" gene complement(3365975..3366334) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" downshifts complement(3365995) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" CDS complement(3366349..3368259) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" gene complement(3366349..3368259) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" CDS complement(3368261..3368986) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" gene complement(3368261..3368986) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" S_feature complement(3368987..3369075) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3369075..3369094) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369075) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" S_feature complement(3369077..3369206) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3369110..3369113) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3369232..3369861) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" gene complement(3369232..3369861) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" downshifts complement(3369251) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" CDS complement(3369858..3370616) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" gene complement(3369858..3370616) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" CDS complement(3370613..3371350) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" gene complement(3370613..3371350) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" CDS complement(3371347..3371985) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" gene complement(3371347..3371985) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" promotor_no_box 3371843..3371943 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3371903 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3371986..3372570) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" gene complement(3371986..3372570) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" CDS complement(3372567..3373850) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" gene complement(3372567..3373850) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" CDS complement(3373847..3374488) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" gene complement(3373847..3374488) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" CDS complement(3374481..3375656) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " gene complement(3374481..3375656) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" S_feature complement(3375657..3375734) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3375700..3375706 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375718..3375737 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3375718..3375737) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3375731 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3375734) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" promotor_-35 complement(3375750..3375757) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3375866..3375885 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3375873 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" CDS 3375907..3376659 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" gene 3375907..3376659 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" S_feature 3376660..3376898 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3376681..3376692) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376687) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3376707..3376713) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3376899..3377564 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" gene 3376899..3377564 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" downshifts 3377535 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" CDS complement(3377584..3378102) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" gene complement(3377584..3378102) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" downshifts complement(3377618) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" CDS complement(3378106..3378756) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" gene complement(3378106..3378756) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" CDS complement(3378753..3379691) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" gene complement(3378753..3379691) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" CDS complement(3379715..3380524) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" gene complement(3379715..3380524) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" CDS complement(3380538..3381470) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" gene complement(3380538..3381470) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" promotor_-10 complement(3381512..3381531) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381518) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" promotor_-35 complement(3381547..3381552) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3381587..3381594 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3381606 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3381609..3381626 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3381652..3382842 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" gene 3381652..3382842 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" promotor_-35 3382640..3382646 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3382661 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3382662..3382680 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3382839..3383567 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" gene 3382839..3383567 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" CDS 3383585..3384316 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" gene 3383585..3384316 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" CDS complement(3384336..3388205) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" gene complement(3384336..3388205) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" downshifts complement(3384458) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3388225..3388236) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388232) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" promotor_-35 complement(3388251..3388257) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3388295..3388301 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388315..3388334 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388320 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" CDS 3388370..3388843 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" gene 3388370..3388843 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" S_feature 3388844..3388951 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3388884..3390101) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" gene complement(3388884..3390101) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" downshifts complement(3388897) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" promotor_-35 3388923..3388928 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388943..3388954 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3388953..3389238 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3388953 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" downshifts 3389195 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" CDS complement(3390117..3390863) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" gene complement(3390117..3390863) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" S_feature complement(3390864..3391050) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3391036..3391055) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391050) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" promotor_-35 complement(3391069..3391076) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3391184..3391191 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391206..3391225 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391218 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" S_feature 3391219..3391288 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3391289..3391798 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" gene 3391289..3391798 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" S_feature complement(3391694..3393032) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3391735) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" CDS 3391819..3393030 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" gene 3391819..3393030 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" downshifts 3393028 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" CDS complement(3393058..3393417) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" gene complement(3393058..3393417) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" S_feature 3393073..3393789 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3393077) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" CDS complement(3393419..3393616) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" gene complement(3393419..3393616) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" CDS complement(3393621..3394718) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" gene complement(3393621..3394718) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" CDS complement(3394743..3395069) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" gene complement(3394743..3395069) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" promotor_-10 complement(3395122..3395137) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395137) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" S_feature complement(3395139..3395629) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3395149..3395158) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3395217..3395220 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3395235..3395254 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3395245 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" CDS 3395287..3395517 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" gene 3395287..3395517 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" promotor_-10 complement(3395620..3395639) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3395630) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" promotor_-35 complement(3395655..3395659) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3395716..3396198) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" gene complement(3395716..3396198) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo downshifts 3395724 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" downshifts complement(3395739) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" upshifts complement(3395871) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3395879..3395882) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3395959..3395963) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395959) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3395979..3395982) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3396199..3396332) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3396360..3399233) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" gene complement(3396360..3399233) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" downshifts complement(3396377) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" CDS complement(3399241..3401226) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" gene complement(3399241..3401226) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" promotor_-10 complement(3401260..3401279) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401272) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" S_feature complement(3401274..3401359) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3401291..3401298) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3401404) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" CDS complement(3401412..3401642) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" gene complement(3401412..3401642) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" promotor_-10 complement(3401669..3401688) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3401679) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" S_feature complement(3401681..3401745) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3401702..3401709) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3401722..3401740) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401743) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" promotor_-35 complement(3401755..3401761) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3401811) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" promotor_no_box complement(3401837..3401937) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3401877) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3401959..3401966 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3401980..3401999 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3401997 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3402089..3404584 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" gene 3402089..3404584 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" misc_feature 3404599..3404603 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3404617 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" CDS 3404660..3405229 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" gene 3404660..3405229 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" CDS 3405260..3406594 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" gene 3405260..3406594 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" downshifts 3406575 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" CDS complement(3406642..3407835) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" gene complement(3406642..3407835) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" downshifts complement(3406651) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" downshifts complement(3406716) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" S_feature complement(3407836..3407913) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3407839) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" CDS complement(3407914..3408252) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" gene complement(3407914..3408252) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo CDS complement(3408227..3408343) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" gene complement(3408227..3408343) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo S_feature complement(3408344..3408433) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3408415..3408433) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408433) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" S_feature complement(3408435..3408515) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3408447..3408452) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3408501..3408519) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408515) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3408533..3408540) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3408652..3410094) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" gene complement(3408652..3410094) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" downshifts complement(3408741) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" promotor_-10 complement(3410140..3410151) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410151) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3410166..3410172) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3410234..3411124) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" gene complement(3410234..3411124) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" downshifts complement(3410251) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" CDS complement(3411117..3411803) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" gene complement(3411117..3411803) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" S_feature complement(3411804..3411936) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3411926..3411945) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411936) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" promotor_-35 complement(3411960..3411963) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3412037..3412375) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" gene complement(3412037..3412375) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" downshifts complement(3412038) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3412402..3412421) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3412415) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" CDS complement(3412424..3413308) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" gene complement(3412424..3413308) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" promotor_-35 complement(3412435..3412442) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3413296..3413315) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3413317) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" promotor_-35 complement(3413330..3413337) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3414465..3414536), complement(3413435..3414463)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" gene complement(3413435..3414536) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" downshifts complement(3413451) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" S_feature complement(3414537..3414605) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3414606..3417131) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" gene complement(3414606..3417131) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" S_feature complement(3417132..3417212) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3417202..3417221) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3417212) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" CDS complement(3417299..3417868) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" gene complement(3417299..3417868) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" downshifts complement(3417307) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" promotor_-35 3417835..3417841 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3417854..3417873 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3417861 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3417895..3417913) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417903) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3417905..3418025) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3417925..3417933) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3418009..3418027) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418025) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" promotor_-35 complement(3418043..3418048) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3418059..3418436) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" gene complement(3418059..3418436) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" CDS complement(3418446..3418787) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" gene complement(3418446..3418787) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" CDS complement(3418784..3419185) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" gene complement(3418784..3419185) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" CDS complement(3419207..3420703) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" gene complement(3419207..3420703) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" CDS complement(3420721..3421050) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" gene complement(3420721..3421050) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" downshifts 3421047 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" promotor_-10 complement(3421072..3421090) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421087) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3421089..3421193) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3421104..3421111) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3421182..3421201) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3421193) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" CDS complement(3421283..3422197) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" gene complement(3421283..3422197) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" downshifts complement(3421303) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" S_feature complement(3422198..3422306) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3422264..3422265 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3422274..3422288 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3422283 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3422285..3422303) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3422306) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" promotor_-35 complement(3422316..3422323) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3422342..3422566) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" gene complement(3422342..3422566) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" downshifts complement(3422381) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" CDS complement(3422560..3422991) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" gene complement(3422560..3422991) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" CDS complement(3423012..3423587) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" gene complement(3423012..3423587) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" CDS complement(3423634..3424530) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" gene complement(3423634..3424530) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" downshifts complement(3423657) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" misc_feature 3423946..3423949 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3423955 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3424541..3426064) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " gene complement(3424541..3426064) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" CDS complement(3426083..3426565) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" gene complement(3426083..3426565) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" CDS complement(3426581..3426847) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" gene complement(3426581..3426847) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" S_feature complement(3426848..3426927) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3426928..3427347) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" gene complement(3426928..3427347) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" promotor_-10 complement(3427386..3427404) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427397) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3427418..3427425) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3427421..3428143) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" gene complement(3427421..3428143) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" CDS complement(3428107..3428403) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" gene complement(3428107..3428403) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" promotor_-10 complement(3428429..3428448) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428442) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3428459..3428466) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3428463..3429854) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" gene complement(3428463..3429854) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" promotor_-10 complement(3429868..3429887) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429883) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3429901..3429908) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3429960..3430805) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" gene complement(3429960..3430805) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" downshifts complement(3429971) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" promotor_-35 3430222..3430229 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3430243..3430262 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3430253..3431985 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3430253 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" promotor_-10 complement(3430832..3430851) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430851) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" promotor_-35 complement(3430866..3430869) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3430903..3431592) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" gene complement(3430903..3431592) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" downshifts complement(3430917) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" S_feature complement(3431593..3431674) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3431675..3432832) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" gene complement(3431675..3432832) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" S_feature complement(3432833..3432960) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3432880..3432883 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3432898..3432917 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3432909..3432995 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3432909 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 complement(3432954..3432973) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432960) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" promotor_-35 3432977..3432985 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3432984..3432991) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3432997 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 3432999..3433007 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3433049..3433702 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " gene 3433049..3433702 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" S_feature complement(3433405..3433997) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3433702..3434877 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " gene 3433702..3434877 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" promotor_-10 complement(3433993..3434011) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434002) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" promotor_-35 complement(3434025..3434031) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3434849 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" CDS complement(3434950..3436026) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" gene complement(3434950..3436026) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" downshifts complement(3434966) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3435012..3435021 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435035..3435054 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3435043..3436276 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3435043 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" S_feature complement(3436027..3436109) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3436097..3436116) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436109) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" promotor_-35 complement(3436128..3436134) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3436171..3437364) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" gene complement(3436171..3437364) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" downshifts complement(3436201) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" CDS complement(3437393..3438151) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" gene complement(3437393..3438151) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" CDS complement(3438175..3438855) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" gene complement(3438175..3438855) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" CDS complement(3438884..3440350) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" gene complement(3438884..3440350) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" S_feature complement(3440351..3440434) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3440435..3441820) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" gene complement(3440435..3441820) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" CDS complement(3441882..3443051) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" gene complement(3441882..3443051) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" CDS complement(3443048..3444499) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" gene complement(3443048..3444499) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" CDS complement(3444555..3444704) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" gene complement(3444555..3444704) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo CDS complement(3444649..3445188) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" gene complement(3444649..3445188) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo misc_feature complement(3445244..3445261) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3445248) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" CDS complement(3445415..3446905) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" gene complement(3445415..3446905) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" downshifts complement(3445437) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" CDS complement(3446944..3449061) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" gene complement(3446944..3449061) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" CDS complement(3449085..3449393) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" gene complement(3449085..3449393) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" downshifts 3449299 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" promotor_-35 3449389..3449393 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449402..3449416 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3449403..3449421) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449409 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3449435..3449442) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3449438) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" promotor_-35 3449459..3449467 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449481..3449494 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449499 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" CDS 3449577..3450497 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" gene 3449577..3450497 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" downshifts 3450487 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" CDS complement(3450537..3451679) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" gene complement(3450537..3451679) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" downshifts complement(3450561) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3451718..3451737) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451732) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" promotor_-35 complement(3451752..3451755) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3451808..3451812 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451828..3451847 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3451829..3451924 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3451830 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" CDS 3451925..3452803 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" gene 3451925..3452803 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" S_feature 3452804..3453895 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3452873..3453228) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3453137..3453355 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" gene 3453137..3453355 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" CDS complement(3453229..3453312) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" gene complement(3453229..3453312) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo S_feature complement(3453313..3453504) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3453505..3456207) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" gene complement(3453505..3456207) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" S_feature complement(3456208..3456330) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3456229..3456235 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456250..3456268 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3456255..3459087 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3456255 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" CDS complement(3456331..3457671) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" gene complement(3456331..3457671) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo CDS complement(3457712..3457918) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" gene complement(3457712..3457918) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo S_feature complement(3457919..3458792) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3458786..3458805) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3458792) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" S_feature complement(3458794..3459033) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3458818..3458824) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3459015..3459033) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3459033) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" promotor_-35 complement(3459047..3459054) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3459056..3459063 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3459075..3459094 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3459089..3459219 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3459089 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" promotor_no_box 3459161..3459261 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3459221 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" CDS 3459225..3459821 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" gene 3459225..3459821 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo downshifts 3459419 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" CDS complement(3459860..3461443) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" gene complement(3459860..3461443) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" downshifts 3459903 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" CDS complement(3461463..3462290) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " gene complement(3461463..3462290) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" S_feature complement(3462291..3462355) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3462351..3462370) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462355) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" S_feature complement(3462357..3462454) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3462386..3462389) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3462455..3464695) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" gene complement(3462455..3464695) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" CDS complement(3464695..3466716) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" gene complement(3464695..3466716) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" promotor_-35 3465458..3465467 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465480..3465495 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3465491 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3466717..3466876) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3466877..3467266) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" gene complement(3466877..3467266) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" S_feature complement(3467267..3467401) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3467385..3467404) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467401) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" promotor_-35 complement(3467415..3467422) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3467556..3467562 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3467573..3467665 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3467573 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" promotor_-10 3467574..3467593 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3467666..3468436 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" gene 3467666..3468436 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" S_feature complement(3467793..3468141) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3468145..3468156) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468149) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" promotor_-35 complement(3468171..3468177) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3468461 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" CDS 3468469..3469614 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" gene 3468469..3469614 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" downshifts 3469602 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" promotor_-35 3469656..3469663 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3469678..3469697 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3469688 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" CDS 3469734..3471062 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" gene 3469734..3471062 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" downshifts 3471057 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" downshifts complement(3471118) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" CDS complement(3471122..3473764) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" gene complement(3471122..3473764) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" promotor_-10 complement(3472367..3472386) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472369) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3472399..3472408) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3473799..3473817) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3473804) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" promotor_-35 complement(3473831..3473838) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3473893..3474843) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" gene complement(3473893..3474843) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" downshifts complement(3473905) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3474868..3474886) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474873) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" S_feature complement(3474875..3475011) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3474901..3474907) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3474985..3475004) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3475013) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" promotor_-35 3475041..3475047 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3475061..3475072 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3475061 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" CDS 3475108..3476559 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" gene 3475108..3476559 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" CDS 3476565..3477671 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" gene 3476565..3477671 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" CDS 3477668..3478792 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" gene 3477668..3478792 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" S_feature complement(3477895..3478789) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3478782 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" CDS complement(3478829..3480202) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" gene complement(3478829..3480202) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" downshifts complement(3478834) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" S_feature complement(3480203..3480266) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3480254..3480272) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480267) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" promotor_-35 complement(3480287..3480293) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3480353..3480362 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3480374..3480389 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3480376..3480496 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3480376 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" promotor_-35 3480471..3480478 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3480492..3480511 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3480498 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" CDS 3480535..3481503 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" gene 3480535..3481503 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" downshifts 3481488 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" promotor_-35 3481547..3481554 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3481569..3481588 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3481576..3481658 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3481576 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" CDS 3481659..3482519 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" gene 3481659..3482519 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" downshifts 3482500 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" CDS complement(3482553..3483794) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" gene complement(3482553..3483794) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" downshifts complement(3482572) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(3483816..3483834) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483838) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" promotor_-35 complement(3483847..3483854) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3483935..3484102) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" gene complement(3483935..3484102) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" downshifts complement(3483962) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" CDS complement(3484117..3485259) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" gene complement(3484117..3485259) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" CDS complement(3485278..3485727) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" gene complement(3485278..3485727) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" promotor_-35 3485421..3485427 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3485435 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" promotor_-10 3485441..3485459 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3485448..3487657 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3485742..3486923) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" gene complement(3485742..3486923) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" promotor_-35 3487637..3487644 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3487659 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" promotor_-10 3487660..3487679 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487680) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3487685..3487699) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3487707..3487711) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3487707..3488687 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" gene 3487707..3488687 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" promotor_-35 3488536..3488543 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3488557..3488576 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3488572 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" CDS 3488689..3489570 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" gene 3488689..3489570 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" CDS 3489567..3489962 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" gene 3489567..3489962 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" CDS 3489978..3491459 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" gene 3489978..3491459 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" CDS 3491461..3492429 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" gene 3491461..3492429 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" CDS 3492441..3493358 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" gene 3492441..3493358 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" promotor_-35 3493367..3493373 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3493388..3493406 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3493390 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" CDS 3493440..3493976 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" gene 3493440..3493976 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" downshifts 3493959 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" S_feature 3494004..3494114 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3494083..3494089 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3494104..3494115 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3494116 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" CDS 3494132..3494428 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" gene 3494132..3494428 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" S_feature 3494429..3495081 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3494468..3494995) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" gene complement(3494468..3494995) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" downshifts complement(3494478) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3495015..3495034) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3495028) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" downshifts 3495039 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(3495048..3495055) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3495094) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" CDS complement(3495095..3495862) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" gene complement(3495095..3495862) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" CDS complement(3495924..3497636) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" gene complement(3495924..3497636) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" promotor_-35 3496535..3496544 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3496558..3496577 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3496558 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3497690..3497709) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3497695) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" promotor_-35 3497715..3497722 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3497724..3497728) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3497736..3497755 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3497746 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" CDS 3497794..3498702 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" gene 3497794..3498702 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" promotor_-35 3498770..3498778 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3498780..3498912 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3498780 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" promotor_-10 3498792..3498811 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3498913..3500241 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" gene 3498913..3500241 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" downshifts 3500232 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" CDS complement(3500298..3500975) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" gene complement(3500298..3500975) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" downshifts complement(3500308) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" CDS complement(3501035..3502177) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" gene complement(3501035..3502177) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" promotor_-10 complement(3502214..3502233) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502222) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" S_feature complement(3502224..3502304) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3502247..3502255) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3502305..3503393) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" gene complement(3502305..3503393) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" S_feature complement(3503394..3503507) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3503449..3503458 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503471..3503490 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503484 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" upshifts complement(3503507) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-10 complement(3503511..3503525) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3503534..3503538) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3503534..3504121 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" gene 3503534..3504121 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" CDS 3503622..3504101 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " gene 3503622..3504101 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" S_feature complement(3504005..3504202) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3504038 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" downshifts complement(3504048) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" downshifts 3504107 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" downshifts 3504186 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(3504201..3504220) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3504207) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-35 3504229..3504236 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3504233..3504242) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3504251..3504270 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3504257 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" CDS 3504295..3504912 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" gene 3504295..3504912 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" S_feature 3504913..3505013 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3504970 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" promotor_-35 3505039..3505048 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3505060..3505075 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3505061 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3505090..3505425 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" gene 3505090..3505425 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" promotor_-10 complement(3505381..3505399) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505390) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3505414..3505419) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3505424 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" CDS complement(3505430..3507007) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" gene complement(3505430..3507007) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" S_feature 3505469..3507180 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3507158..3507165 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3507176..3507195 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3507182 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3507221..3507697 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" gene 3507221..3507697 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" CDS 3507711..3508304 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" gene 3507711..3508304 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" CDS 3508301..3508837 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" gene 3508301..3508837 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" downshifts 3508818 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" CDS complement(3508864..3509085) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" gene complement(3508864..3509085) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" upshifts 3509032 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3509039..3509040 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3509082..3509627) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" gene complement(3509082..3509627) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" promotor_-35 3509644..3509651 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3509666..3509685 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3509670 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" CDS 3509750..3510631 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" gene 3509750..3510631 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" CDS complement(3510716..3511432) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" gene complement(3510716..3511432) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" downshifts complement(3510736) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" CDS complement(3511442..3511906) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" gene complement(3511442..3511906) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" CDS complement(3511896..3513704) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" gene complement(3511896..3513704) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" CDS complement(3513723..3513983) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" gene complement(3513723..3513983) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" CDS complement(3513993..3514415) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" gene complement(3513993..3514415) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" S_feature complement(3514416..3514498) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3514490..3514509) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514498) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" promotor_-35 complement(3514522..3514529) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514632..3514757) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" gene complement(3514632..3514757) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" S_feature complement(3514675..3514806) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3514718) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" CDS complement(3514807..3515592) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" gene complement(3514807..3515592) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" S_feature complement(3515593..3515708) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3515701..3515720) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515708) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" promotor_-35 complement(3515734..3515741) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3515784..3517106) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" gene complement(3515784..3517106) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" downshifts complement(3515796) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" upshifts complement(3517140) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" S_feature complement(3517142..3517267) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3517142..3517160) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3517176..3517181) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3517247..3517266) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3517267) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" CDS complement(3517301..3518065) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" gene complement(3517301..3518065) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" downshifts complement(3518084) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" CDS complement(3518118..3518831) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" gene complement(3518118..3518831) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" downshifts complement(3518135) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" CDS complement(3518821..3519567) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" gene complement(3518821..3519567) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" promotor_-10 complement(3519599..3519618) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519611) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" promotor_-35 complement(3519635..3519638) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3519801..3519944) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" gene complement(3519801..3519944) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" downshifts complement(3519822) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" S_feature complement(3519945..3520030) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3520020..3520031) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3520030) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3520032..3520262) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3520069..3520073 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3520089..3520108 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3520098 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" CDS 3520148..3521758 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" gene 3520148..3521758 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" promotor_-10 complement(3520250..3520268) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3520262) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3520264..3520438) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3520282..3520289) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3520425..3520444) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3520438) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" promotor_-35 complement(3520458..3520466) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3521745..3524513 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" gene 3521745..3524513 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" downshifts complement(3524562) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" CDS complement(3524639..3525496) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" gene complement(3524639..3525496) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" CDS complement(3525502..3526278) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" gene complement(3525502..3526278) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" promotor_-10 complement(3526304..3526323) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526326) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" S_feature complement(3526328..3526400) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3526338..3526345) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3526402..3526501) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3526445) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" CDS complement(3526502..3526843) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" gene complement(3526502..3526843) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" promotor_-10 complement(3526865..3526884) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526884) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" promotor_-35 complement(3526898..3526905) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3526920..3527303) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" gene complement(3526920..3527303) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" promotor_-10 complement(3527325..3527344) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3527332..3527351 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3527336 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3527345) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" promotor_-35 complement(3527359..3527366) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3527426..3527445 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3527429 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" downshifts complement(3527478) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" CDS 3527478..3527888 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" gene 3527478..3527888 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" S_feature 3527889..3527972 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3527930 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" CDS complement(3528028..3528336) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" gene complement(3528028..3528336) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" downshifts complement(3528029) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" CDS 3528680..3529516 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" gene 3528680..3529516 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" promotor_-35 3528896..3528903 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528918..3528937 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3528921 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3529515 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" CDS complement(3529563..3529955) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" gene complement(3529563..3529955) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" downshifts complement(3529569) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" CDS complement(3530028..3530453) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" gene complement(3530028..3530453) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" promotor_-10 complement(3530514..3530533) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3530530) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" S_feature complement(3530532..3530616) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3530548..3530555) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3530595 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" misc_feature 3530598..3530617 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3530608..3530627) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3530616) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" S_feature complement(3530618..3531702) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3530641..3530646) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3530645..3531709 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" gene 3530645..3531709 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" S_feature 3531710..3532594 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3531732..3532541) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" gene complement(3531732..3532541) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" downshifts complement(3531747) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" CDS complement(3532575..3533387) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" gene complement(3532575..3533387) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" S_feature complement(3533388..3533467) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3533418..3533425 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3533439..3533458 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3533448 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3533461..3533479) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3533467) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" promotor_-35 complement(3533493..3533500) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3533550..3534551) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " gene complement(3533550..3534551) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" downshifts complement(3533556) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" misc_feature complement(3534606..3534625) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3534630) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" S_feature complement(3534632..3534716) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3534717..3534998) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" gene complement(3534717..3534998) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" CDS complement(3535013..3535123) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" gene complement(3535013..3535123) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" promotor_-10 complement(3535154..3535172) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535176) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" promotor_-35 complement(3535188..3535193) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3535269..3535275 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3535289..3535308 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3535305 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" CDS 3535348..3535761 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" gene 3535348..3535761 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" CDS 3535783..3536973 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" gene 3535783..3536973 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" CDS complement(3537064..3538470) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" gene complement(3537064..3538470) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" downshifts complement(3537361) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" promotor_-10 complement(3538503..3538522) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3538521) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" promotor_-35 complement(3538537..3538540) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3538576..3540048) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" gene complement(3538576..3540048) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" CDS complement(3540229..3541587) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" gene complement(3540229..3541587) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" downshifts complement(3540243) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" CDS complement(3541587..3542156) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" gene complement(3541587..3542156) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" promotor_-10 complement(3542175..3542186) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542193) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" promotor_-35 complement(3542200..3542206) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3542263..3542430) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" gene complement(3542263..3542430) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo CDS complement(3542340..3542804) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" gene complement(3542340..3542804) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" promotor_-10 complement(3542834..3542853) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542839) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" promotor_-35 complement(3542867..3542874) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3543005..3543008 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543023..3543042 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543027 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" CDS 3543086..3544300 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" gene 3543086..3544300 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" promotor_-10 complement(3543916..3543934) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543917) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3543948..3543955) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3544166..3544172 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544186..3544205 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3544188 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" CDS 3544312..3544662 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" gene 3544312..3544662 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" downshifts 3544655 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" promotor_-35 3544714..3544722 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544736..3544744 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3544743 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" promotor_-35 3544785..3544794 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544807..3544822 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3544811 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" CDS 3544843..3545424 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" gene 3544843..3545424 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" promotor_-10 complement(3544941..3544960) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3544951) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3544974..3544982) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3545405 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" CDS complement(3545465..3545887) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" gene complement(3545465..3545887) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" downshifts complement(3545484) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" promotor_-10 complement(3545922..3545937) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3545941) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" promotor_-35 complement(3545950..3545959) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3545998..3546849) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" gene complement(3545998..3546849) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" downshifts complement(3546007) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" downshifts complement(3546249) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" promotor_-35 3546486..3546488 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3546505..3546524 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3546506..3546852 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3546506 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" misc_feature 3546844..3546847 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3546854..3546989 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3546854 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" upshifts complement(3546883) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" misc_feature complement(3546889..3546898) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3546990..3547481 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" gene 3546990..3547481 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" promotor_-35 3547219..3547224 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3547240..3547258 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3547251 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" S_feature complement(3547342..3548250) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3547478..3547996 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" gene 3547478..3547996 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" downshifts 3547801 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" downshifts 3547999 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" CDS 3548155..3548286 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " gene 3548155..3548286 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" CDS complement(3548283..3548717) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" gene complement(3548283..3548717) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" downshifts complement(3548295) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3548766..3548785) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548773) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" S_feature complement(3548775..3549072) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3548800..3548807) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3548846..3548850 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3548867..3548886 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3548879..3548959 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3548880 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" CDS 3548960..3550408 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" gene 3548960..3550408 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" upshifts complement(3549072) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" promotor_-10 complement(3549073..3549091) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3549074..3549417) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3549107..3549113) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3549395..3549413) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3549417) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" promotor_-35 complement(3549429..3549434) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3550397 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" CDS complement(3550429..3551202) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" gene complement(3550429..3551202) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" downshifts complement(3550451) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" promotor_-35 3551277..3551280 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3551296..3551315 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3551300 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" CDS 3551347..3551730 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" gene 3551347..3551730 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" downshifts 3551717 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" CDS complement(3551765..3552406) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" gene complement(3551765..3552406) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" downshifts complement(3551815) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" CDS complement(3552474..3552875) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" gene complement(3552474..3552875) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" promotor_-10 complement(3552924..3552943) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3552934) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" S_feature complement(3552936..3553009) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3552958..3552963) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3553010..3554719) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" gene complement(3553010..3554719) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" CDS complement(3554716..3555090) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" gene complement(3554716..3555090) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" CDS complement(3555087..3555404) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" gene complement(3555087..3555404) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" S_feature complement(3555405..3555489) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3555489) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" misc_feature complement(3555491..3555504) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3555491..3555584) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3555585..3555749) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" gene complement(3555585..3555749) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" promotor_-10 complement(3555672..3555690) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3555684) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" promotor_-35 complement(3555702..3555710) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3555750..3555921) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3555922..3556104) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" gene complement(3555922..3556104) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo S_feature complement(3556105..3556251) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3556239..3556258) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3556251) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" S_feature complement(3556253..3556366) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3556273..3556280) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" upshifts 3556380 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3556383..3556387 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3556400..3556588) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" gene complement(3556400..3556588) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" downshifts complement(3556411) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" downshifts 3556578 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3556614..3556632) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3556625) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" promotor_-35 complement(3556646..3556652) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3556661..3557161) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" gene complement(3556661..3557161) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" promotor_-10 complement(3557197..3557216) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3557204) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" promotor_-35 complement(3557230..3557236) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3557296..3558429) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" gene complement(3557296..3558429) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" downshifts complement(3557314) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3558456..3558475) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3558463) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" promotor_-10 complement(3558526..3558544) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558542) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" promotor_-35 complement(3558558..3558565) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3558621..3559646) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" gene complement(3558621..3559646) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" downshifts complement(3558634) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" CDS complement(3559662..3560450) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" gene complement(3559662..3560450) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" promotor_-10 complement(3560476..3560495) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3560482) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" S_feature complement(3560484..3560695) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3560509..3560516) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3560696..3560857) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" gene complement(3560696..3560857) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" promotor_-10 complement(3560870..3560888) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3560890) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" promotor_-35 complement(3560902..3560908) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3560951..3561625) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" gene complement(3560951..3561625) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" downshifts complement(3560966) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" CDS complement(3561678..3561818) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" gene complement(3561678..3561818) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" CDS complement(3561949..3562632) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" gene complement(3561949..3562632) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" promotor_-35 3563009..3563013 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3563018..3564049) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" gene complement(3563018..3564049) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" promotor_-10 3563028..3563047 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3563034) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" upshifts 3563046 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3564077..3564095) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564090) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" S_feature complement(3564092..3564209) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3564111..3564116) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3564151..3564156 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3564168..3566828 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3564168 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" promotor_-10 3564172..3564190 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3564245..3565555) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" gene complement(3564245..3565555) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" downshifts complement(3564254) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" promotor_-10 complement(3565579..3565598) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3565586) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" CDS complement(3565589..3566329) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" gene complement(3565589..3566329) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" promotor_-35 complement(3565612..3565621) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3565960) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-10 complement(3565962..3565970) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3565984..3565992) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3566084..3566099) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566092) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-35 complement(3566112..3566121) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3566330..3566457) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3566458..3566688) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" gene complement(3566458..3566688) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" S_feature complement(3566689..3566951) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3566824..3566843 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3566830 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" CDS 3566858..3567331 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" gene 3566858..3567331 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" promotor_-10 complement(3566935..3566954) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3566951) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" S_feature complement(3566953..3567336) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3566969..3566972) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3567365..3567763) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" gene complement(3567365..3567763) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" downshifts complement(3567381) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" promotor_-10 complement(3567755..3567773) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567764) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" promotor_-35 complement(3567787..3567793) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3567787..3569208) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" gene complement(3567787..3569208) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" CDS complement(3569234..3570097) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" gene complement(3569234..3570097) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" S_feature complement(3570098..3570173) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3570174..3571682) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" gene complement(3570174..3571682) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" CDS complement(3571699..3572244) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" gene complement(3571699..3572244) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" CDS complement(3572241..3572753) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" gene complement(3572241..3572753) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" S_feature complement(3572754..3572915) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3572916..3573128) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" gene complement(3572916..3573128) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" CDS complement(3573174..3573908) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" gene complement(3573174..3573908) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" promotor_no_box 3573722..3573822 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3573782 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3573916..3574299) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" gene complement(3573916..3574299) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" misc_feature complement(3573988..3574006) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3573990) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3574300..3574570) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3574532..3574541 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3574541 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3574546..3574565) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3574555..3574574 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3574570) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3574572..3574693) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3574578..3574585) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3574722..3575351) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" gene complement(3574722..3575351) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" downshifts complement(3574738) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3575395..3575414) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3575418) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" promotor_-35 complement(3575429..3575436) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3575486..3576733) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" gene complement(3575486..3576733) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" downshifts complement(3575509) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3576775..3576794) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3576792) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" S_feature complement(3576794..3576878) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3576809..3576814) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3576923) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" CDS complement(3576940..3577482) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" gene complement(3576940..3577482) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" CDS complement(3577495..3577944) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" gene complement(3577495..3577944) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" S_feature complement(3577945..3578044) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3578036..3578055) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3578044) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" promotor_-35 complement(3578069..3578076) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3578101..3578553) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" gene complement(3578101..3578553) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" promotor_-10 complement(3578570..3578589) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3578588) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" promotor_-35 complement(3578604..3578607) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3578629..3579186) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" gene complement(3578629..3579186) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" promotor_-10 complement(3579213..3579231) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3579226) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" promotor_-35 complement(3579247..3579252) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3579265..3580305) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" gene complement(3579265..3580305) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" downshifts complement(3579270) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" S_feature complement(3580306..3580370) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3580360..3580379) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580370) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" S_feature complement(3580372..3580461) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3580395..3580399) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3580462..3580905) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" gene complement(3580462..3580905) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" CDS complement(3580972..3581646) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" gene complement(3580972..3581646) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" promotor_-10 complement(3581408..3581426) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3581415) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" promotor_-35 complement(3581441..3581447) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3581678..3581695) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3581679) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" promotor_-35 complement(3581711..3581716) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3581752 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" misc_feature 3581756..3581775 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3581787..3582149 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" gene 3581787..3582149 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" downshifts complement(3582162) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" CDS complement(3582166..3582453) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" gene complement(3582166..3582453) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" S_feature complement(3582454..3582512) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3582510..3582529) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3582513..3583379) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" gene complement(3582513..3583379) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" upshifts complement(3582526) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" promotor_-35 complement(3582542..3582551) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3583381..3584451) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" gene complement(3583381..3584451) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" downshifts complement(3583384) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" downshifts 3584452 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" promotor_-10 complement(3584479..3584498) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3584503) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" S_feature complement(3584505..3584616) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3584512..3584518) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3584548..3584567 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3584562 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" CDS 3584577..3584963 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" gene 3584577..3584963 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" promotor_-10 complement(3584598..3584616) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3584616) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" promotor_-35 complement(3584630..3584637) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3585031..3585039 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3585050..3585068 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3585051 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" CDS 3585085..3585639 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" gene 3585085..3585639 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" misc_feature 3585569..3585573 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3585574 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3585618 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" CDS complement(3585673..3586632) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" gene complement(3585673..3586632) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" downshifts complement(3585695) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3586670..3586688) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586684) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3586703..3586709) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3586714..3588462) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" gene complement(3586714..3588462) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" promotor_-10 complement(3587188..3587206) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3587196) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3587221..3587227) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3588463..3588553) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3588537..3588556) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3588553) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3588570..3588577) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3588696) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" CDS complement(3588701..3589288) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" gene complement(3588701..3589288) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" CDS complement(3589377..3589577) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" gene complement(3589377..3589577) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" downshifts complement(3589390) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" S_feature complement(3589578..3589655) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3589651..3589670) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589655) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3589684..3589691) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3589696..3590979) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" gene complement(3589696..3590979) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" S_feature complement(3590980..3591282) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3591010..3591171) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" gene complement(3591010..3591171) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" promotor_-10 complement(3591262..3591281) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591282) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3591297..3591301) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3591386..3592351) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" gene complement(3591386..3592351) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" downshifts complement(3591392) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" promotor_-35 3591968..3591977 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3591990..3592009 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3591998 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3592382..3593671) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" gene complement(3592382..3593671) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" S_feature complement(3593672..3594031) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3594050..3594688) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" gene complement(3594050..3594688) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" downshifts complement(3594076) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" S_feature complement(3594689..3594807) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3594808..3595665) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" gene complement(3594808..3595665) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" S_feature complement(3595666..3595792) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3595774..3595793) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3595792) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" promotor_-35 complement(3595807..3595814) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3595846..3596220) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" gene complement(3595846..3596220) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" promotor_-10 complement(3596260..3596278) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3596274) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" S_feature complement(3596276..3596915) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3596277..3596280 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3596289..3596297) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3596296..3596315 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3596309 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" promotor_-35 3596323..3596328 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3596344..3596363 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3596354 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" CDS 3596386..3596907 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" gene 3596386..3596907 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" promotor_-35 3596850..3596853 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3596868..3596887 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3596882 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3596905..3596924) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3596915) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" downshifts 3596926 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3596939..3596946) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3596989..3598596) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" gene complement(3596989..3598596) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" downshifts complement(3597002) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" S_feature complement(3598597..3598784) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3598772..3598791) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598784) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3598806..3598813) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3598838..3599359) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" gene complement(3598838..3599359) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" downshifts complement(3598894) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" S_feature complement(3599360..3599462) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3599443..3599462) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3599462) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" S_feature complement(3599464..3599541) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3599478..3599481) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3599542..3600681) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" gene complement(3599542..3600681) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" CDS complement(3600678..3602795) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" gene complement(3600678..3602795) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" S_feature complement(3602796..3602854) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3602855..3602874) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602868) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3602888..3602895) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3602894..3602900 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3602914..3602925 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3602919 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" CDS 3602950..3604146 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" gene 3602950..3604146 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" S_feature complement(3603142..3604020) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3604010..3604028) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604021) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" promotor_-35 complement(3604044..3604049) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3604159..3605121 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" gene 3604159..3605121 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" promotor_-35 3605135..3605141 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3605156..3605174 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3605156 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" CDS 3605202..3605474 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" gene 3605202..3605474 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" downshifts complement(3605208) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" downshifts 3605464 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" S_feature 3605509..3605915 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3605516..3606040) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" gene complement(3605516..3606040) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" downshifts complement(3605538) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" CDS complement(3606050..3607777) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" gene complement(3606050..3607777) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" promotor_-10 complement(3607811..3607830) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3607825) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3607844..3607850) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3607866..3609368) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" gene complement(3607866..3609368) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" promotor_-10 complement(3609392..3609410) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609410) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3609425..3609431) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3609455..3609827) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3609498) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" CDS complement(3609854..3610525) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" gene complement(3609854..3610525) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" downshifts complement(3609872) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" CDS complement(3610522..3611076) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" gene complement(3610522..3611076) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" CDS complement(3611102..3612565) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" gene complement(3611102..3612565) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" CDS complement(3612555..3616241) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" gene complement(3612555..3616241) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" misc_feature complement(3616272..3616291) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3616296) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" S_feature complement(3616298..3616427) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3616437..3616913) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" gene complement(3616437..3616913) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" downshifts complement(3616472) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3616936..3616955) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3616948) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" promotor_-35 complement(3616970..3616973) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3617020 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" misc_feature 3617023..3617042 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3617057..3617776 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" gene 3617057..3617776 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" downshifts 3617760 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" CDS complement(3617808..3618524) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" gene complement(3617808..3618524) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" downshifts complement(3617810) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" downshifts complement(3617880) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" misc_feature complement(3618550..3618569) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3618562) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" CDS complement(3618623..3619810) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" gene complement(3618623..3619810) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" misc_feature complement(3619840..3619859) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3619858) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" CDS complement(3619946..3621616) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" gene complement(3619946..3621616) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" downshifts complement(3619948) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" CDS complement(3621613..3622041) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" gene complement(3621613..3622041) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" misc_feature 3622109..3622123 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3622109..3622128) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622116 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3622125) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" promotor_-35 complement(3622145..3622148) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3622180..3622199) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3622192) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" promotor_-35 3622272..3622279 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3622287 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" promotor_-10 3622292..3622311 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3622336 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" CDS 3622354..3622485 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " gene 3622354..3622485 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" CDS 3622442..3622594 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" gene 3622442..3622594 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" downshifts 3622474 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" promotor_-35 3622589..3622595 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3622610..3622629 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622613 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" CDS 3622619..3623965 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" gene 3622619..3623965 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" CDS 3623978..3624139 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" gene 3623978..3624139 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" CDS 3624136..3624855 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" gene 3624136..3624855 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" CDS 3624848..3626158 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" gene 3624848..3626158 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" CDS 3626148..3627308 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" gene 3626148..3627308 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" CDS 3627313..3628593 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" gene 3627313..3628593 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" CDS 3628590..3629291 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" gene 3628590..3629291 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" downshifts complement(3628858) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" S_feature complement(3628947..3629296) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3628990) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" S_feature 3629292..3631774 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3629297..3630673) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" gene complement(3629297..3630673) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" CDS complement(3630712..3632067) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" gene complement(3630712..3632067) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" promotor_-10 complement(3632103..3632122) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632121) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" promotor_-35 complement(3632135..3632144) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3632247..3632266 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3632248 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" downshifts complement(3632293) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" CDS 3632297..3633442 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" gene 3632297..3633442 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" promotor_-35 3633301..3633305 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3633322..3633341 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3633329 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" downshifts complement(3633412) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" CDS 3633426..3633545 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" gene 3633426..3633545 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" downshifts 3633530 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" S_feature 3633575..3633643 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3633644..3634117 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" gene 3633644..3634117 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" downshifts 3634106 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" CDS complement(3634149..3635021) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" gene complement(3634149..3635021) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" downshifts complement(3634160) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" downshifts complement(3634226) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" CDS complement(3635082..3635912) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" gene complement(3635082..3635912) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" S_feature complement(3635913..3636008) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3635996..3636015) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3636007) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" promotor_-35 complement(3636028..3636035) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3636053..3636058 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3636074..3636092 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3636076 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" CDS 3636114..3638189 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" gene 3636114..3638189 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" downshifts complement(3638242) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" S_feature complement(3638366..3638481) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3638409) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" CDS complement(3638482..3639000) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" gene complement(3638482..3639000) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" CDS complement(3639014..3639673) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" gene complement(3639014..3639673) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" promotor_-35 3639696..3639699 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3639709..3639728) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3639714..3639733 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3639717 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" upshifts complement(3639727) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" S_feature complement(3639729..3640012) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3639743..3639750) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3639782..3639970 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" gene 3639782..3639970 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" downshifts 3639959 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" CDS complement(3640013..3640432) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" gene complement(3640013..3640432) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" promotor_-10 complement(3640482..3640501) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640493) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" promotor_-35 complement(3640516..3640523) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3640552..3642468) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" gene complement(3640552..3642468) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" promotor_-10 complement(3641746..3641764) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3641751) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3641781..3641785) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3642499) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" misc_RNA complement(3642522..3642743) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3642522..3642743) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" misc_RNA complement(3642775..3642996) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3642775..3642996) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" S_feature complement(3643028..3643290) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3643039 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" downshifts complement(3643071) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3643078..3643233) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" gene complement(3643078..3643233) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" promotor_-35 3643240..3643243 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3643252..3643265 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3643259 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3643267..3643286) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643290) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" promotor_-35 complement(3643300..3643306) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3643313..3644713) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" gene complement(3643313..3644713) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" CDS complement(3644713..3645183) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" gene complement(3644713..3645183) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" downshifts complement(3645139) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" CDS complement(3645295..3645795) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" gene complement(3645295..3645795) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" downshifts complement(3645298) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" CDS complement(3645831..3647132) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" gene complement(3645831..3647132) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" promotor_-10 complement(3647156..3647175) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647170) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" S_feature complement(3647172..3647293) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3647191..3647193) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3647294..3647518) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" gene complement(3647294..3647518) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" S_feature complement(3647519..3647603) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3647592..3647611) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647602) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" promotor_-35 complement(3647626..3647629) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3647669..3647675 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3647690..3647701 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3647691 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" CDS 3647733..3648509 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" gene 3647733..3648509 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" downshifts 3648495 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" promotor_-35 3648597..3648604 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3648619..3648638 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3648623..3652849 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3648623 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" CDS complement(3648653..3649543) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" gene complement(3648653..3649543) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" promotor_no_box complement(3649543..3649643) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3649583) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" CDS complement(3649711..3650556) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" gene complement(3649711..3650556) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" downshifts complement(3649874) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" CDS complement(3650605..3651504) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" gene complement(3650605..3651504) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" promotor_-10 complement(3651547..3651566) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3651550) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" promotor_-35 complement(3651580..3651587) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3651651) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" CDS complement(3651651..3652622) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" gene complement(3651651..3652622) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" promotor_-10 complement(3652657..3652676) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3652682) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3652692..3652696) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3652770..3652781) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3652773) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3652795..3652801) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3652844..3652863 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3652851 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" CDS 3652892..3653656 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" gene 3652892..3653656 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" downshifts 3653643 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" promotor_-35 3653719..3653725 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3653739..3653758 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3653748 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" CDS 3653789..3654568 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" gene 3653789..3654568 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" downshifts 3654545 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" CDS complement(3654583..3655782) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" gene complement(3654583..3655782) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" CDS complement(3655783..3656967) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" gene complement(3655783..3656967) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" CDS complement(3656964..3658382) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" gene complement(3656964..3658382) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" CDS complement(3658401..3659162) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" gene complement(3658401..3659162) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" CDS complement(3659165..3659872) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" gene complement(3659165..3659872) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" misc_feature complement(3659768..3659769) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3659769) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" CDS complement(3659862..3660476) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" gene complement(3659862..3660476) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" promotor_-35 3660034..3660040 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3660056..3660074 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3660067..3660678 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3660067 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" promotor_-10 complement(3660499..3660518) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3660515) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" promotor_-35 complement(3660533..3660540) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3660627) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" CDS complement(3660628..3661866) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" gene complement(3660628..3661866) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" promotor_-10 complement(3661908..3661927) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661920) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" promotor_-35 complement(3661939..3661946) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3662076..3663488) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" gene complement(3662076..3663488) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" downshifts complement(3662083) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" CDS complement(3663488..3665188) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" gene complement(3663488..3665188) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" misc_feature complement(3664157..3664173) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3664169) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" CDS complement(3665262..3666809) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" gene complement(3665262..3666809) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" downshifts complement(3665269) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" upshifts complement(3666853) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" S_feature complement(3666855..3667035) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3666856..3666874) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3667036..3668310) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" gene complement(3667036..3668310) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" S_feature complement(3668311..3668393) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3668393) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" misc_feature complement(3668406..3668424) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3668486) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" CDS complement(3668487..3668951) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" gene complement(3668487..3668951) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" S_feature complement(3668952..3669062) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3669044..3669063) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3669062) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" promotor_-35 complement(3669078..3669085) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3669273) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" CDS complement(3669275..3669730) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" gene complement(3669275..3669730) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" misc_feature 3669365..3669384 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3669373 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3669723..3670574) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" gene complement(3669723..3670574) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" CDS complement(3670588..3671535) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" gene complement(3670588..3671535) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" CDS complement(3671535..3672275) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" gene complement(3671535..3672275) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" promotor_-35 3672293..3672298 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3672299 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3672300..3673319) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" gene complement(3672300..3673319) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" promotor_-10 3672313..3672331 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3673183..3673192 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3673205..3673220 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3673216 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3673322..3674044) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" gene complement(3673322..3674044) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" CDS complement(3674037..3675158) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" gene complement(3674037..3675158) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" CDS complement(3675158..3676027) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" gene complement(3675158..3676027) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" CDS complement(3676028..3677197) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" gene complement(3676028..3677197) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" CDS complement(3677218..3678642) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" gene complement(3677218..3678642) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" CDS complement(3678647..3679417) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" gene complement(3678647..3679417) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" promotor_-10 complement(3679452..3679471) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3679466) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" promotor_-35 complement(3679485..3679494) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3679585..3679590 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679606..3679624 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3679608..3679736 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3679608 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" CDS 3679737..3680282 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" gene 3679737..3680282 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" downshifts 3680268 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" CDS complement(3680326..3680697) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" gene complement(3680326..3680697) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" downshifts complement(3680344) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" CDS complement(3680759..3682081) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" gene complement(3680759..3682081) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" CDS complement(3682101..3682418) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" gene complement(3682101..3682418) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" promotor_-10 complement(3682447..3682466) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3682458) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" promotor_-35 complement(3682480..3682486) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3682521..3682528 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3682544..3682563 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3682547 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" CDS 3682586..3683956 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" gene 3682586..3683956 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" CDS complement(3683981..3684658) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" gene complement(3683981..3684658) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" downshifts complement(3683995) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3684485..3684504) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684501) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3684520..3684525) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3684672..3685478) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" gene complement(3684672..3685478) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" promotor_-10 complement(3684971..3684989) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684985) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" promotor_-35 complement(3685004..3685010) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3685507..3685526) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3685513) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" promotor_-35 complement(3685542..3685549) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3685568..3686101) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" gene complement(3685568..3686101) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" CDS complement(3686149..3686784) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" gene complement(3686149..3686784) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" CDS complement(3686777..3687115) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" gene complement(3686777..3687115) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" promotor_-10 complement(3687137..3687156) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3687148) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" promotor_-35 complement(3687171..3687178) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3687199..3687202 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3687217..3687236 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3687217 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" CDS 3687259..3688074 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" gene 3687259..3688074 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" downshifts 3688053 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" downshifts complement(3688129) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" CDS complement(3688164..3688412) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" gene complement(3688164..3688412) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" downshifts complement(3688184) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" upshifts complement(3688430) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" S_feature complement(3688432..3688505) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3688440..3688446) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3688506..3689945) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" gene complement(3688506..3689945) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" CDS complement(3689942..3691327) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" gene complement(3689942..3691327) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" misc_feature complement(3691346..3691355) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3691360) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" S_feature complement(3691362..3691426) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3691405..3691422) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691426) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3691438..3691445) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3691468..3691487) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691486) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3691501..3691508) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3691567..3691570 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3691577 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" promotor_-10 3691585..3691604 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3691629..3692399 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" gene 3691629..3692399 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" S_feature 3692400..3693467 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3692438..3693268) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" gene complement(3692438..3693268) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" downshifts complement(3692439) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3693294..3693313) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3693300) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" CDS complement(3693308..3693610) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" gene complement(3693308..3693610) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" promotor_-35 complement(3693328..3693335) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3693611..3693749) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3693734..3693753) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3693749) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" promotor_-35 3694064..3694072 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3694083..3694101 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3694084 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" CDS 3694140..3696560 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" gene 3694140..3696560 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" upshifts 3694298 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3694307..3694326 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3696548 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" CDS complement(3696598..3697599) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " gene complement(3696598..3697599) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" S_feature complement(3697600..3697761) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3697773..3698522) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" gene complement(3697773..3698522) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" downshifts complement(3697806) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" promotor_-10 complement(3698540..3698559) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698557) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" promotor_-35 complement(3698574..3698577) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3698628..3699809) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" gene complement(3698628..3699809) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" downshifts complement(3698642) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3699810..3699941) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3699935..3699950) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3699941) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" promotor_-35 complement(3699962..3699971) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3700176..3700183 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3700194..3700304 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3700194..3700213 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3700194 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" CDS 3700305..3700568 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" gene 3700305..3700568 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" downshifts 3700458 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" downshifts 3700574 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" CDS complement(3700611..3700985) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" gene complement(3700611..3700985) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" downshifts complement(3700622) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" CDS complement(3700987..3701601) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" gene complement(3700987..3701601) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" CDS complement(3701615..3703564) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" gene complement(3701615..3703564) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" misc_feature 3702828..3702847 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3702834 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box 3703258..3703358 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3703318 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3703428 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" CDS complement(3703592..3704557) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" gene complement(3703592..3704557) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" S_feature complement(3704558..3704626) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3704613..3704632) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3704626) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3704628..3704813) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3704645..3704649) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3704744..3704749 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3704765..3704783 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3704770 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3704804..3704823) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3704813) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3704815..3704924) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3704838..3704842) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3704880 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(3704909..3704928) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3704924) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-35 complement(3704944..3704948) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3705002..3705020) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3705007..3705013 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3705019) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-10 3705028..3705046 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3705031 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" promotor_-35 complement(3705036..3705041) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3705073..3705318 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" gene 3705073..3705318 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" downshifts 3705300 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" CDS complement(3705389..3706930) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" gene complement(3705389..3706930) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" downshifts complement(3705418) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" CDS complement(3706934..3708106) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" gene complement(3706934..3708106) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" promotor_-10 complement(3708124..3708142) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3708146) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3708157..3708163) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3708187..3708570) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" gene complement(3708187..3708570) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" CDS complement(3708588..3709259) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" gene complement(3708588..3709259) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" promotor_-10 complement(3709281..3709300) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3709290) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3709316..3709319) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3709400..3709403 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3709418..3709437 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3709427..3709614 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3709427 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" CDS 3709615..3709773 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" gene 3709615..3709773 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" S_feature 3709774..3710158 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3710139..3710144 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3710160..3710178 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3710160 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" CDS 3710216..3710524 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" gene 3710216..3710524 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" downshifts complement(3710302) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3710306..3710406) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3710346) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3710521..3712062 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" gene 3710521..3712062 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" downshifts 3712053 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" CDS complement(3712093..3712695) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" gene complement(3712093..3712695) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" downshifts complement(3712107) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" S_feature complement(3712696..3712977) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3712978..3714228) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" gene complement(3712978..3714228) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" downshifts complement(3713074) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" CDS complement(3714247..3715404) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" gene complement(3714247..3715404) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" misc_feature complement(3714320..3714339) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3714347) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" CDS complement(3715401..3716846) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" gene complement(3715401..3716846) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" promotor_-10 complement(3716880..3716899) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716890) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" promotor_-35 complement(3716913..3716920) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3717003..3717671) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" gene complement(3717003..3717671) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" downshifts complement(3717012) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" CDS complement(3717668..3718486) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" gene complement(3717668..3718486) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" CDS complement(3718494..3719399) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" gene complement(3718494..3719399) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" misc_feature complement(3719134..3719153) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3719145) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" promotor_-10 complement(3719440..3719459) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3719450..3719457 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3719461) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" upshifts 3719469 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" promotor_-10 3719471..3719490 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3719475..3719482) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3719505..3719891 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" gene 3719505..3719891 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" CDS 3719873..3720550 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" gene 3719873..3720550 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" downshifts 3720522 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" promotor_-35 3720594..3720601 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3720612 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" promotor_-10 3720615..3720634 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3720654..3721853 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" gene 3720654..3721853 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" CDS 3721887..3722084 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" gene 3721887..3722084 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" downshifts 3722063 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" CDS complement(3722120..3723310) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" gene complement(3722120..3723310) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" downshifts complement(3722135) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" downshifts complement(3722219) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" misc_feature complement(3723334..3723353) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3723350) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" promotor_-35 3723370..3723377 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3723386 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" promotor_-10 3723391..3723410 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3723431..3723811 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" gene 3723431..3723811 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" downshifts 3723709 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" downshifts 3723780 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" CDS complement(3723849..3724526) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" gene complement(3723849..3724526) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" downshifts complement(3723856) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3724535..3724554) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3724560) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" promotor_-35 complement(3724566..3724572) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3724603..3725937) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" gene complement(3724603..3725937) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" misc_feature complement(3725985..3726003) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3726008) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" promotor_-35 3726102..3726109 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3726114 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" promotor_-10 3726123..3726141 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3726165..3728102 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" gene 3726165..3728102 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" promotor_-10 complement(3727309..3727328) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3727310) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3727342..3727350) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3728092 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" promotor_-35 3728205..3728212 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3728227..3728246 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3728246 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3728458..3728465 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3728478..3728497 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3728478 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" CDS 3728530..3729909 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" gene 3728530..3729909 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" S_feature complement(3729618..3730821) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3729963..3730805 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" gene 3729963..3730805 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" CDS complement(3730856..3731716) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" gene complement(3730856..3731716) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" downshifts complement(3730866) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" downshifts 3731700 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" promotor_-10 complement(3731738..3731756) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3731756) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" promotor_-35 complement(3731771..3731777) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3731826..3732539) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" gene complement(3731826..3732539) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" promotor_-35 3731941..3731942 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3731962..3731979 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3731964 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3732567..3732578) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3732568) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3732593..3732599) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3732614..3732620 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3732635..3732654 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3732645 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" CDS 3732690..3733205 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" gene 3732690..3733205 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" misc_RNA 3733206..3733412 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene 3733206..3733412 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" downshifts 3733372 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" CDS 3733454..3734695 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" gene 3733454..3734695 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" promotor_-35 3734786..3734794 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3734805..3734823 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3734816 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" CDS 3734851..3736218 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" gene 3734851..3736218 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" downshifts 3736195 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" CDS complement(3736248..3736880) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" gene complement(3736248..3736880) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" downshifts complement(3736266) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3736916..3736931) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3736924) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" promotor_-35 complement(3736944..3736952) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3737022..3737957) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" gene complement(3737022..3737957) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" downshifts complement(3737034) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" promotor_-35 3737701..3737710 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3737724..3737743 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3737728 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3737958..3738045) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3738028..3738047) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3738045) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3738063..3738067) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3738090..3738102) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3738090) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3738117..3738123) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3738120..3738254) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" gene complement(3738120..3738254) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" promotor_-35 3738201..3738208 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3738222..3738241 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3738231 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" S_feature 3738234..3738338 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3738333..3738342 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3738340 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" promotor_-10 3738354..3738369 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3738376) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3738378..3738392) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3738404..3738553 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" gene 3738404..3738553 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" CDS 3738571..3740082 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" gene 3738571..3740082 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" CDS 3740079..3741266 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" gene 3740079..3741266 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" CDS 3741283..3741519 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" gene 3741283..3741519 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" CDS 3741519..3742697 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" gene 3741519..3742697 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" S_feature 3742698..3742787 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3742788..3743546 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" gene 3742788..3743546 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" downshifts 3743514 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" S_feature complement(3743548..3744775) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3743594..3743601 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3743615..3743634 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3743628 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" CDS 3743687..3744778 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" gene 3743687..3744778 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" downshifts 3744680 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" downshifts 3744768 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" CDS complement(3744812..3746140) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" gene complement(3744812..3746140) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" downshifts complement(3744820) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" CDS complement(3746137..3746469) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" gene complement(3746137..3746469) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" CDS complement(3746488..3747846) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" gene complement(3746488..3747846) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" CDS complement(3747862..3748170) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" gene complement(3747862..3748170) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" promotor_-10 complement(3748215..3748234) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3748231) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" promotor_-35 complement(3748248..3748254) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3748299) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" CDS complement(3748299..3750224) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" gene complement(3748299..3750224) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" promotor_-35 3748962..3748971 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3748985..3749004 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3748993 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3750297..3750314) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3750321) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" promotor_-35 complement(3750329..3750336) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3750387..3750545) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" gene complement(3750387..3750545) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" downshifts complement(3750414) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" CDS complement(3750574..3751164) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" gene complement(3750574..3751164) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" promotor_-10 complement(3751192..3751210) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3751203) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" promotor_-35 complement(3751224..3751230) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3751233..3751239 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3751255..3751273 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3751258 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" CDS 3751293..3752936 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" gene 3751293..3752936 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" S_feature complement(3751430..3752979) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3752931 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" S_feature complement(3752981..3753072) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3752983..3752989 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3752997 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3753004..3753023 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3753024) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" CDS 3753041..3754243 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" gene 3753041..3754243 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" S_feature complement(3753074..3754239) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3753117) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" CDS complement(3754240..3755016) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" gene complement(3754240..3755016) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" CDS complement(3755013..3755900) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" gene complement(3755013..3755900) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" CDS complement(3755907..3756095) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" gene complement(3755907..3756095) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" CDS complement(3756092..3756298) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" gene complement(3756092..3756298) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" CDS complement(3756295..3756615) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" gene complement(3756295..3756615) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" promotor_-35 3756428..3756437 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3756450..3756469 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3756452 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3756608..3757144) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" gene complement(3756608..3757144) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" upshifts complement(3757172) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" promotor_-10 complement(3757173..3757188) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3757200..3757209) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3757275..3757282 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3757296..3757315 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3757305 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" CDS 3757356..3758729 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" gene 3757356..3758729 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" S_feature complement(3757636..3758178) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3758166..3758185) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3758178) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3758200..3758207) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3758564 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" CDS complement(3758744..3759574) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" gene complement(3758744..3759574) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" downshifts complement(3758750) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" promotor_-10 complement(3759593..3759611) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759608) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" promotor_-35 complement(3759626..3759632) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3759652) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3759654..3759673) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3759660..3761387) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" gene complement(3759660..3761387) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" downshifts complement(3759759) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" CDS complement(3761384..3763087) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" gene complement(3761384..3763087) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" CDS complement(3763087..3764103) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" gene complement(3763087..3764103) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" promotor_-10 complement(3763977..3763995) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3763986) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" promotor_-35 complement(3764011..3764016) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3764087..3765493) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" gene complement(3764087..3765493) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" S_feature complement(3765494..3765702) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3765685..3765704) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3765702) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" S_feature complement(3765704..3765812) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3765718..3765723) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3765809..3765828) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3765824) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" promotor_-35 complement(3765842..3765849) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3765970..3765977 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3765987 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" promotor_-10 3765992..3766010 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3766049..3767401 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" gene 3766049..3767401 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" S_feature complement(3767000..3769482) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3767386 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" misc_feature 3767477..3767496 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3767483 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" CDS 3767523..3769211 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" gene 3767523..3769211 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" promotor_-35 3769209..3769218 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3769230..3769245 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3769234 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" CDS 3769269..3769469 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" gene 3769269..3769469 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" S_feature 3769470..3770414 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3769483..3770322) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" gene complement(3769483..3770322) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" promotor_-10 complement(3770348..3770366) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3770366) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" promotor_-35 complement(3770379..3770386) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3770381 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" CDS complement(3770429..3771526) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" gene complement(3770429..3771526) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" downshifts complement(3770430) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(3771559..3771578) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3771576) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" S_feature complement(3771578..3771646) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3771591..3771598) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3771647..3772540) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" gene complement(3771647..3772540) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" promotor_-10 complement(3772567..3772586) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772586) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" promotor_-35 complement(3772600..3772607) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3772614..3772619 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3772635..3772653 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3772644 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3772661..3772667 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3772682..3772700 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3772688 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" CDS 3772724..3774181 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" gene 3772724..3774181 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" promotor_-10 complement(3773607..3773625) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3773622) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3773640..3773645) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3774162 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" downshifts 3774206 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" CDS complement(3774223..3775059) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" gene complement(3774223..3775059) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" downshifts complement(3774241) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" misc_RNA complement(3775136..3775238) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" gene complement(3775136..3775238) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" downshifts complement(3775162) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3775264..3775283) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3775275) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" S_feature complement(3775277..3776018) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3775297..3775303) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3775355..3775362 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3775375..3775393 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3775384 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" S_feature 3775394..3775479 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3775455..3775462 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3775476..3775495 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3775481 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" CDS 3775627..3776169 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" gene 3775627..3776169 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" promotor_-10 complement(3775994..3776013) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3776018) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" promotor_-35 complement(3776027..3776036) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3776159 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" S_feature 3776204..3776526 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3776244..3777263) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" gene complement(3776244..3777263) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" downshifts complement(3776262) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3777289..3777308) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3777303) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" promotor_-35 complement(3777323..3777326) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3777378..3777884) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" gene complement(3777378..3777884) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" promotor_-10 complement(3777890..3777909) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3777912) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" promotor_-35 3777914..3777917 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3777923..3777929) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3777932..3777951 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3777935 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" CDS 3778014..3778889 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" gene 3778014..3778889 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" S_feature complement(3778264..3778352) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3778286) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3778312..3778412) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3778352) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" CDS 3778967..3779440 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" gene 3778967..3779440 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" CDS 3779458..3780678 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" gene 3779458..3780678 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" CDS 3780665..3781321 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" gene 3780665..3781321 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" promotor_-35 3781319..3781324 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3781338..3781357 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3781341 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" CDS 3781371..3782603 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" gene 3781371..3782603 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" downshifts complement(3781388) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" downshifts 3782588 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" promotor_-35 3782649..3782658 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3782671..3782686 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3782673..3782895 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3782673 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3782852 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" promotor_-35 3782906..3782912 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3782925..3783025 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3782925 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" promotor_-10 3782927..3782945 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3783004..3783011 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3783025..3783043 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3783027..3783124 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3783027 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" CDS 3783125..3783388 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" gene 3783125..3783388 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" promotor_-35 3783152..3783155 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3783170..3783189 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3783182 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3783336 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" downshifts 3783380 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" promotor_-35 3783455..3783464 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3783470 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" promotor_-10 3783476..3783491 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3783517..3784005 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" gene 3783517..3784005 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" promotor_-35 3784010..3784017 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3784031..3784050 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3784041 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3784071..3784177 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3784071..3784177 /gene="mswI" /locus_tag="BSU_misc_RNA_61" downshifts 3784172 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" CDS 3784260..3785393 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" gene 3784260..3785393 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" S_feature complement(3784533..3784776) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3784771..3784790) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3784780) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" promotor_-35 complement(3784805..3784812) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3785399..3785406 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785421..3785440 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785427 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3785462..3785568 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3785462..3785568 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" downshifts 3785515 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" S_feature 3785569..3785645 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3785646..3786782 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" gene 3785646..3786782 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" downshifts 3786769 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" CDS complement(3786835..3787608) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" gene complement(3786835..3787608) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" downshifts complement(3786845) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" CDS complement(3787625..3788275) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" gene complement(3787625..3788275) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" CDS complement(3788272..3788988) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" gene complement(3788272..3788988) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" CDS complement(3789012..3790430) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" gene complement(3789012..3790430) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" promotor_-10 complement(3789598..3789616) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3789617) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3789632..3789637) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3790431..3790515) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3790499..3790517) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3790515) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3790533..3790538) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3790584..3791432) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" gene complement(3790584..3791432) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" downshifts complement(3790594) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" S_feature complement(3791433..3791618) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3791607..3791626) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3791618) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" S_feature complement(3791620..3792345) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3791642..3791646) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3791780..3791787 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3791800..3791819 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3791809 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" misc_RNA 3791819..3791921 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene 3791819..3791921 /gene="gswB" /locus_tag="BSU_misc_RNA_63" S_feature 3791922..3792025 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3791997..3792003 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3792017..3792028 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3792027 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" CDS 3792048..3793241 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" gene 3792048..3793241 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" promotor_-10 complement(3792332..3792350) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3792348) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" promotor_-35 complement(3792363..3792370) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3793017 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" downshifts 3793237 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" CDS complement(3793283..3793711) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" gene complement(3793283..3793711) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo CDS complement(3793712..3793954) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" gene complement(3793712..3793954) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo S_feature complement(3793955..3794018) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3794007..3794022) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794018) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" promotor_-35 complement(3794034..3794043) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3794051 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" CDS complement(3794099..3794389) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" gene complement(3794099..3794389) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" downshifts complement(3794105) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3794414..3794433) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794431) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" CDS complement(3794439..3796499) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" gene complement(3794439..3796499) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" promotor_-35 complement(3794447..3794454) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3796528..3796546) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3796532) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" promotor_-35 complement(3796561..3796567) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3796592..3796597 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3796611 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" promotor_-10 3796613..3796631 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3796625..3796699 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3796700..3797980 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" gene 3796700..3797980 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" S_feature 3797981..3798120 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3798077 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" CDS complement(3798138..3798866) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" gene complement(3798138..3798866) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" downshifts complement(3798155) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3798897..3798916) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3798908) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" promotor_-35 complement(3798930..3798937) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3799054..3799161) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3799097) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" CDS complement(3799162..3799995) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" gene complement(3799162..3799995) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" promotor_-10 complement(3800026..3800045) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3800045) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" promotor_-35 complement(3800059..3800066) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3800091..3800771) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" gene complement(3800091..3800771) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" promotor_-10 complement(3800818..3800837) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3800827) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" promotor_-35 complement(3800851..3800858) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3800919..3800922 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3800937..3800956 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3800937 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" CDS 3800978..3802264 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" gene 3800978..3802264 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" promotor_-10 complement(3801709..3801727) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3801717) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3801741..3801748) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3802235 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" CDS complement(3802283..3803722) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" gene complement(3802283..3803722) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" downshifts complement(3802306) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" misc_feature complement(3803746..3803765) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3803763) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" CDS complement(3803804..3804952) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" gene complement(3803804..3804952) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" promotor_-10 complement(3804979..3804995) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3804995) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" S_feature complement(3804997..3805081) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3805010..3805015) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3805082..3805270) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" gene complement(3805082..3805270) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo CDS complement(3805301..3805432) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " gene complement(3805301..3805432) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" CDS complement(3805444..3805905) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" gene complement(3805444..3805905) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" CDS complement(3805921..3806217) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" gene complement(3805921..3806217) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" CDS complement(3806245..3806733) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" gene complement(3806245..3806733) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" CDS complement(3806751..3807203) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" gene complement(3806751..3807203) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" S_feature complement(3807204..3807272) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3807273..3807602) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" gene complement(3807273..3807602) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" S_feature complement(3807603..3807724) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3807725..3808141) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" gene complement(3807725..3808141) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" CDS complement(3808192..3808560) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" gene complement(3808192..3808560) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" CDS complement(3808554..3809024) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" gene complement(3808554..3809024) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" S_feature complement(3809025..3809349) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3809350..3809778) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" gene complement(3809350..3809778) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" CDS complement(3809840..3816844) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" gene complement(3809840..3816844) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" misc_feature 3816851..3816865 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3816865 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3816875..3816894) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3816890) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" promotor_-35 complement(3816909..3816916) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3817006..3817941) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" gene complement(3817006..3817941) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" downshifts complement(3817227) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" S_feature complement(3817942..3818062) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3818093..3818539) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" gene complement(3818093..3818539) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" downshifts complement(3818107) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3818576..3818595) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3818583) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" promotor_-35 complement(3818609..3818616) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3818642..3820051) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" gene complement(3818642..3820051) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" CDS complement(3820074..3821903) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" gene complement(3820074..3821903) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" promotor_no_box complement(3821895..3821995) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3821935) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" S_feature complement(3821937..3822129) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3822110..3822129) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3822129) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" S_feature complement(3822131..3822264) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3822142..3822149) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3822286..3822594) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" gene complement(3822286..3822594) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" downshifts complement(3822309) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" CDS complement(3822640..3823083) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" gene complement(3822640..3823083) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" CDS complement(3823080..3824789) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" gene complement(3823080..3824789) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" misc_feature complement(3823951..3823970) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3823959) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" CDS complement(3824809..3825078) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" gene complement(3824809..3825078) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" CDS complement(3825090..3825455) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" gene complement(3825090..3825455) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" S_feature complement(3825456..3825521) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3825508..3825527) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3825521) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" promotor_-35 complement(3825542..3825545) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3825762..3827171) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" gene complement(3825762..3827171) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" downshifts complement(3825785) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" S_feature complement(3827172..3827281) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3827305..3827469) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" gene complement(3827305..3827469) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" promotor_-10 complement(3827354..3827372) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3827369) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3827383..3827391) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3827661..3827680) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3827677) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3827693..3827700) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3827709..3827716 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3827731..3827750 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3827734 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" CDS 3827788..3828234 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" gene 3827788..3828234 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" downshifts 3828239 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" CDS 3828347..3829873 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" gene 3828347..3829873 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" CDS 3829870..3831528 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" gene 3829870..3831528 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" CDS 3831541..3832806 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" gene 3831541..3832806 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" CDS 3832799..3833758 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" gene 3832799..3833758 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" S_feature 3833759..3833833 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3833834..3835261 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" gene 3833834..3835261 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" downshifts 3835257 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" CDS complement(3835305..3836606) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" gene complement(3835305..3836606) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" downshifts complement(3835322) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" CDS complement(3836636..3837817) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" gene complement(3836636..3837817) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" S_feature complement(3837818..3837897) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3837898..3838569) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" gene complement(3837898..3838569) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" promotor_-35 3838518..3838521 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3838536 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3838537..3838556 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3838597..3838616) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3838612) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" promotor_-35 complement(3838630..3838637) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3838675..3839616) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" gene complement(3838675..3839616) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" promotor_-10 complement(3839661..3839680) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3839667) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" S_feature complement(3839669..3839749) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3839696..3839699) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3839750..3840577) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " gene complement(3839750..3840577) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" downshifts complement(3840549) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(3840602..3840620) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3840615) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" promotor_-35 complement(3840634..3840640) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3840650..3841762) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" gene complement(3840650..3841762) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" CDS complement(3841832..3843169) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" gene complement(3841832..3843169) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" CDS complement(3843166..3844308) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" gene complement(3843166..3844308) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" CDS complement(3844325..3845074) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" gene complement(3844325..3845074) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" CDS complement(3845087..3845761) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" gene complement(3845087..3845761) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" CDS complement(3845784..3846578) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" gene complement(3845784..3846578) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" promotor_-35 3846150..3846159 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3846171 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3846172..3846187 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3846603..3847100) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" gene complement(3846603..3847100) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" CDS complement(3847114..3848439) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" gene complement(3847114..3848439) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" promotor_-10 complement(3848516..3848535) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3848520) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" promotor_-35 complement(3848549..3848556) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3848625..3848852) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" gene complement(3848625..3848852) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" CDS complement(3848839..3849825) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" gene complement(3848839..3849825) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" downshifts complement(3848843) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" promotor_-35 3848976..3848985 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3848999..3849018 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3849009..3849642 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3849009 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" promotor_-10 complement(3849880..3849899) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3849891) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" promotor_-35 complement(3849914..3849921) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3849980..3850792) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" gene complement(3849980..3850792) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" promotor_-10 complement(3850822..3850841) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3850832..3851389) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" gene complement(3850832..3851389) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" upshifts complement(3850845) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3850856..3850863) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3851370..3851804) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" gene complement(3851370..3851804) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" promotor_-35 3851829..3851838 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3851848 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" promotor_-10 3851851..3851870 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3851864) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" S_feature complement(3851865..3852276) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3851870..3851884) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3851893..3851897) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3851893..3852258 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" gene 3851893..3852258 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" downshifts 3852272 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" promotor_-10 complement(3852276..3852280) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852276) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" S_feature complement(3852278..3852364) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-35 complement(3852301) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3852357..3852376) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852364) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3852390..3852397) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3852437..3852443 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3852457..3852468 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3852464 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" CDS 3852506..3852859 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" gene 3852506..3852859 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" downshifts 3852854 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" CDS complement(3852903..3853301) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" gene complement(3852903..3853301) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" downshifts complement(3852911) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3853316..3853335) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3853332) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" promotor_-35 complement(3853350..3853353) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3853389..3853396 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3853405..3853423) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3853411..3853430 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3853420 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" upshifts complement(3853420) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3853439..3853444) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3853479..3854444 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" gene 3853479..3854444 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" upshifts 3853872 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3853879..3853897 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3854351 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" downshifts 3854422 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" S_feature 3854467..3855263 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3854485..3854832) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" gene complement(3854485..3854832) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" downshifts complement(3854498) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3854846..3856714) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" gene complement(3854846..3856714) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" CDS complement(3856689..3857462) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" gene complement(3856689..3857462) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" CDS complement(3857606..3858583) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" gene complement(3857606..3858583) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" CDS complement(3858580..3859269) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" gene complement(3858580..3859269) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" promotor_-10 complement(3859296..3859315) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3859314) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" promotor_-35 complement(3859330..3859336) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3859377..3860249) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" gene complement(3859377..3860249) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" downshifts complement(3859381) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" CDS complement(3860270..3861106) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" gene complement(3860270..3861106) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" S_feature complement(3861107..3861191) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3861192..3862061) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" gene complement(3861192..3862061) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" CDS complement(3862081..3863115) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" gene complement(3862081..3863115) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" CDS complement(3863138..3864454) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" gene complement(3863138..3864454) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" CDS complement(3864469..3865362) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" gene complement(3864469..3865362) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" CDS complement(3865379..3867292) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" gene complement(3865379..3867292) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" CDS complement(3867325..3868302) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" gene complement(3867325..3868302) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" CDS complement(3868326..3869141) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" gene complement(3868326..3869141) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" S_feature complement(3869142..3869215) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3869216..3870679) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" gene complement(3869216..3870679) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" S_feature complement(3870680..3870884) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3870683..3870690 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3870706..3870725 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3870713 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" S_feature 3870720..3871026 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3870866..3870885) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3870884) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" S_feature complement(3870886..3871038) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3870900..3870907) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3870986..3870993 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3871008..3871027 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3871028 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" promotor_-10 complement(3871039..3871058) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3871055) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" promotor_-35 complement(3871074..3871081) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3871095..3871850 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" gene 3871095..3871850 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" promotor_-35 3871829..3871835 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3871850..3871869 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3871864 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3871904..3872836 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" gene 3871904..3872836 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" downshifts 3872838 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" promotor_-35 3872915..3872922 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3872936..3872955 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3872942..3873097 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3872942 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3873098..3873748 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" gene 3873098..3873748 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" CDS 3873752..3874060 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" gene 3873752..3874060 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" downshifts 3874062 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3874204..3874210 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3874226..3874244 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3874236 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" CDS 3874298..3875683 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" gene 3874298..3875683 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" downshifts 3875669 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" S_feature 3875714..3876264 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3875725..3877605) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" gene complement(3875725..3877605) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" downshifts complement(3875731) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" S_feature complement(3877606..3877703) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3877694..3877713) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3877703) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" promotor_-35 complement(3877728..3877735) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3877773..3878024) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" gene complement(3877773..3878024) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" downshifts complement(3877791) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" misc_feature complement(3878046..3878065) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3878055) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" promotor_-35 3878088..3878094 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3878108..3878126 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3878109 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" CDS 3878141..3878962 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" gene 3878141..3878962 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" downshifts 3878946 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" CDS complement(3878991..3880133) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" gene complement(3878991..3880133) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" downshifts complement(3879001) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" S_feature complement(3880134..3880233) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3880221..3880240) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3880232) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" promotor_-35 complement(3880254..3880261) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3880276..3881613 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" gene 3880276..3881613 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" S_feature complement(3881018..3881618) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3881652..3882131) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " gene complement(3881652..3882131) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" downshifts complement(3881663) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" CDS complement(3882211..3883203) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" gene complement(3882211..3883203) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" downshifts complement(3882235) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" downshifts 3883193 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" promotor_-10 complement(3883226..3883245) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3883244) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" promotor_-35 complement(3883260..3883267) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3883266..3883273 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3883287..3883711 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3883287 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" promotor_-10 3883288..3883307 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3883293..3883705 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 3883293..3883705 /gene="srlX" /locus_tag="BSU_misc_RNA_86" upshifts complement(3883313) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3883323..3883337) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3883345..3883349) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3883677 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" CDS 3883712..3884446 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" gene 3883712..3884446 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" CDS 3884446..3884715 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" gene 3884446..3884715 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" CDS 3884719..3885201 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" gene 3884719..3885201 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" CDS 3885222..3887465 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" gene 3885222..3887465 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" CDS 3887462..3888661 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" gene 3887462..3888661 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" promotor_-10 complement(3888417..3888435) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3888439) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3888450..3888456) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3888652 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" downshifts complement(3888725) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" CDS complement(3888725..3889957) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" gene complement(3888725..3889957) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" promotor_-10 complement(3889989..3890008) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3890001) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3890022..3890027) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3890058..3890483) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" gene complement(3890058..3890483) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" promotor_-10 complement(3890511..3890530) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3890525) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3890543..3890549) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3890675..3890682 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3890692 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" promotor_-10 3890697..3890716 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3890740..3891195 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" gene 3890740..3891195 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" downshifts 3891133 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" S_feature 3891196..3891809 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3891225..3892433) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" gene complement(3891225..3892433) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" downshifts complement(3891252) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" S_feature complement(3892434..3892540) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3892541..3893554) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" gene complement(3892541..3893554) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" S_feature complement(3893555..3893628) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3893613..3893632) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3893628) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" promotor_-35 complement(3893645..3893652) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3893648..3894223) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" gene complement(3893648..3894223) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" downshifts complement(3893672) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3894252..3894271) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3894266) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" promotor_-35 complement(3894286..3894293) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3894294..3894300 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3894315..3894333 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3894322 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" CDS 3894354..3895424 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" gene 3894354..3895424 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" downshifts 3895422 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" CDS complement(3895481..3895912) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" gene complement(3895481..3895912) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" promotor_-35 3895942..3895949 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3895963..3895982 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3895972..3896138 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3895972 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" promotor_-10 complement(3896024..3896043) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3896044) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" promotor_-35 complement(3896058..3896065) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3896139..3896543 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" gene 3896139..3896543 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" S_feature complement(3896160..3897212) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3896513..3897205 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" gene 3896513..3897205 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" CDS complement(3897245..3898276) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" gene complement(3897245..3898276) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" downshifts complement(3897257) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" promotor_-35 3898243..3898246 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3898259 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3898263..3898282 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3898313..3898331) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3898331) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" promotor_-35 complement(3898346..3898352) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3898369..3899517) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" gene complement(3898369..3899517) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" promotor_-10 complement(3899556..3899575) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3899567) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" promotor_-35 complement(3899586..3899593) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3899639..3899646 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3899660..3899679 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3899667 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" CDS 3899713..3900444 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" gene 3899713..3900444 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" CDS 3900437..3901978 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" gene 3900437..3901978 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" CDS 3902007..3903353 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" gene 3902007..3903353 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" promotor_-35 3902806..3902810 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3902826..3902845 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3902835 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" CDS 3903376..3904782 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" gene 3903376..3904782 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" downshifts 3904771 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" misc_feature 3904879..3904898 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3904881..3905172 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3904881 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" promotor_-35 3905145..3905152 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3905167..3905186 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3905174 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 3905196..3905203 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3905218..3905237 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3905221) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3905224..3905238) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3905233 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 complement(3905246..3905250) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3905246..3905809 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" gene 3905246..3905809 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" CDS 3905823..3907352 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" gene 3905823..3907352 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" downshifts complement(3907179) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" downshifts 3907345 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" S_feature complement(3907378..3907461) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3907421) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" CDS complement(3907462..3908901) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" gene complement(3907462..3908901) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" CDS complement(3908915..3909145) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" gene complement(3908915..3909145) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" S_feature complement(3909146..3909357) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3909354..3909373) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3909359) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" promotor_-35 complement(3909388..3909395) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3909421..3909428 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3909439..3909458 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3909454 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" CDS 3909489..3910199 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" gene 3909489..3910199 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" CDS 3910227..3910385 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" gene 3910227..3910385 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" downshifts 3910462 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" CDS complement(3910516..3911238) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" gene complement(3910516..3911238) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" downshifts complement(3910528) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" promotor_-35 3911139..3911142 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3911158..3911162 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3911173 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3911259..3911888) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" gene complement(3911259..3911888) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" S_feature complement(3911889..3912037) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3912038..3912796) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" gene complement(3912038..3912796) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" promotor_-10 complement(3912486..3912505) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3912502) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3912518..3912525) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3912777..3913736) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" gene complement(3912777..3913736) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" downshifts 3913725 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" misc_feature 3913772..3913775 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3913780 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3913794..3913943) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" gene complement(3913794..3913943) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" downshifts complement(3913801) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" misc_feature 3913852..3913869 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3913857 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3913938 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3913964..3913983) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3913985) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3913998..3914005) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3914278..3914285 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3914300..3914319 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3914304 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" CDS 3914415..3916340 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" gene 3914415..3916340 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" S_feature 3916341..3917705 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3916553..3916873) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3916874..3918634) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" gene complement(3916874..3918634) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" downshifts complement(3916917) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" misc_feature 3917702..3917703 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3917707 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3918634..3919032) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" gene complement(3918634..3919032) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" CDS complement(3919025..3920470) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" gene complement(3919025..3920470) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" promotor_-35 3919720..3919727 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3919739..3919758 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3919749..3920798 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3919749 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" S_feature complement(3920471..3920731) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3920732..3921211) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " gene complement(3920732..3921211) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" S_feature complement(3921212..3921291) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3921292..3921462) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" gene complement(3921292..3921462) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" promotor_-10 complement(3921503..3921522) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3921519) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" promotor_-35 complement(3921536..3921541) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3921585..3921592 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3921605..3921624 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3921622 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" CDS 3921647..3922060 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" gene 3921647..3922060 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" downshifts 3922040 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" CDS complement(3922094..3923320) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" gene complement(3922094..3923320) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" downshifts complement(3922109) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" promotor_-10 complement(3923343..3923361) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3923348) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" promotor_-35 complement(3923373..3923381) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3923383..3923553) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" gene complement(3923383..3923553) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" promotor_-10 complement(3923572..3923590) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3923590) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" promotor_-35 complement(3923604..3923610) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3923658..3923906) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" gene complement(3923658..3923906) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" CDS complement(3923922..3925085) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" gene complement(3923922..3925085) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" promotor_-10 complement(3923956..3923974) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3923964) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3923986..3923994) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3925096..3925833) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" gene complement(3925096..3925833) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" promotor_-10 complement(3925875..3925893) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3925881) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3925907..3925915) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3925975..3926445) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" gene complement(3925975..3926445) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" downshifts complement(3925988) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" S_feature complement(3926446..3926516) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3926477..3926483 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3926497..3926516 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3926498..3926517) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3926498 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" upshifts complement(3926516) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" S_feature complement(3926518..3926793) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3926532..3926539) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3926556..3927653 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" gene 3926556..3927653 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" promotor_-10 complement(3926784..3926802) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3926793) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" promotor_-35 complement(3926817..3926822) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3927377..3927385 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3927397..3927415 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3927410 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" CDS 3927654..3927770 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" gene 3927654..3927770 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" downshifts 3927759 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" CDS complement(3928007..3928897) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" gene complement(3928007..3928897) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" downshifts complement(3928013) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" downshifts complement(3928075) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" CDS complement(3928971..3930374) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" gene complement(3928971..3930374) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" S_feature complement(3930375..3930596) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3930597..3931802) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" gene complement(3930597..3931802) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" misc_feature complement(3931859..3931877) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3931862) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" promotor_-35 3931972..3931977 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3931992..3932011 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3932007 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" CDS 3932043..3933428 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" gene 3932043..3933428 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" CDS complement(3933410..3933598) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" gene complement(3933410..3933598) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo CDS complement(3933715..3933843) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" gene complement(3933715..3933843) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" downshifts 3933767 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" CDS complement(3933863..3935065) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" gene complement(3933863..3935065) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" downshifts complement(3933887) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3935097..3935108) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3935097) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" promotor_-35 complement(3935123..3935129) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3935147..3935941) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" gene complement(3935147..3935941) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" CDS complement(3935963..3936805) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" gene complement(3935963..3936805) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" CDS complement(3936792..3938159) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" gene complement(3936792..3938159) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" CDS complement(3938149..3939984) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" gene complement(3938149..3939984) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" CDS complement(3939992..3940699) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" gene complement(3939992..3940699) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" S_feature complement(3940700..3940796) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3940784..3940803) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3940796) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" S_feature complement(3940798..3940990) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3940819..3940822) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3940990) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" misc_feature complement(3941000..3941019) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3941082) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" tRNA complement(3941083..3941155) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3941083..3941155) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" tRNA complement(3941191..3941267) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3941191..3941267) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" S_feature complement(3941268..3941348) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3941349..3941420) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3941349..3941420) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" tRNA complement(3941430..3941505) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3941430..3941505) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" misc_feature 3941477..3941493 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3941490 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3941506..3941602) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3941586..3941605) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3941602) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" promotor_-35 complement(3941619..3941626) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3941636..3941736) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3941676) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" CDS complement(3941729..3943021) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" gene complement(3941729..3943021) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" downshifts complement(3941740) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(3943061..3943080) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3943081) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" promotor_-35 complement(3943095..3943102) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3943227..3943646) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" gene complement(3943227..3943646) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" promotor_-10 complement(3943644..3943655) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3943655) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" promotor_-35 complement(3943670..3943676) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3943767..3945131) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" gene complement(3943767..3945131) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" downshifts complement(3943787) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" downshifts complement(3943831) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3945162..3945181) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3945176) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" promotor_-35 complement(3945196..3945198) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3945243..3945249 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3945264..3945282 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3945266 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" CDS 3945301..3945501 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" gene 3945301..3945501 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" downshifts 3945471 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" S_feature 3945516..3945837 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3945549..3945752) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" gene complement(3945549..3945752) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" S_feature complement(3945753..3946053) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3945818..3945821 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3945836..3945855 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3945839 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" CDS 3945873..3946013 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" gene 3945873..3946013 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" S_feature 3946014..3946085 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3946061) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" promotor_-10 complement(3946064..3946078) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3946086..3946090) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3946086..3947294 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" gene 3946086..3947294 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" downshifts 3947275 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" CDS 3947399..3949456 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" gene 3947399..3949456 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" downshifts 3949321 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" CDS complement(3949493..3949942) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" gene complement(3949493..3949942) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" downshifts complement(3949507) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" CDS complement(3949939..3951918) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" gene complement(3949939..3951918) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" misc_feature complement(3950420..3950439) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3950423) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" promotor_-35 3950836..3950843 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3950857..3950875 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3950861..3951527 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3950861 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" CDS complement(3951955..3952884) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" gene complement(3951955..3952884) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" S_feature complement(3952885..3953021) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3953003..3953022) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3953021) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" promotor_-35 complement(3953037..3953042) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3953111..3953260) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" gene complement(3953111..3953260) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" downshifts complement(3953137) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3953299..3953318) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3953316) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" promotor_-35 complement(3953332..3953338) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3953339..3953348 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3953361..3953380 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3953367 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" upshifts complement(3953379) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3953381..3953894) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3953383..3953397) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3953406..3953410) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3953406..3953888 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" gene 3953406..3953888 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" downshifts 3953875 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3953918..3954295) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" gene complement(3953918..3954295) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" S_feature 3953920..3954449 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3953939) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" promotor_-10 complement(3954350..3954369) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3954362) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" promotor_-35 complement(3954383..3954390) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3954431..3954435 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3954449..3954468 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3954451 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" promotor_-10 complement(3954476..3954490) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3954479) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3954500..3955429 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" gene 3954500..3955429 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" promotor_-35 complement(3954504) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3955415 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" downshifts complement(3955458) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" CDS complement(3955462..3955908) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" gene complement(3955462..3955908) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" S_feature complement(3955909..3956239) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3956098..3956215) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" gene complement(3956098..3956215) /gene="mswM" /locus_tag="BSU_misc_RNA_94" promotor_-10 complement(3956230..3956249) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3956238) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" promotor_-35 complement(3956263..3956270) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3956276..3956282 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3956295 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" promotor_-10 3956297..3956315 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3956311..3956317 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3956332..3956343 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3956339 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" CDS 3956341..3957648 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" gene 3956341..3957648 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" downshifts complement(3957449) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" downshifts 3957637 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" CDS complement(3957692..3957931) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" gene complement(3957692..3957931) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo downshifts complement(3957713) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3957717..3957817) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3957757) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3957921..3958085) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" gene complement(3957921..3958085) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo CDS complement(3958097..3958282) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" gene complement(3958097..3958282) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" downshifts 3958363 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" CDS complement(3958555..3958701) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" gene complement(3958555..3958701) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo CDS complement(3958683..3958832) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" gene complement(3958683..3958832) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo misc_feature complement(3959148..3959164) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3959165) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3959184..3959191 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3959206..3959409 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3959206..3959225 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3959206 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" misc_feature complement(3959227..3959241) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3959231) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" CDS 3959410..3959847 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" gene 3959410..3959847 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" S_feature 3959848..3959924 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3959881 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" CDS 3959961..3960716 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" gene 3959961..3960716 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" S_feature complement(3960556..3963146) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3960706..3961416 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" gene 3960706..3961416 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" downshifts 3960915 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" CDS 3961413..3962168 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" gene 3961413..3962168 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" CDS 3962165..3962821 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKIKKTTVLDNISYTFEKGTIYGLFGSNGSGKTMLL RALSGLIVPTEGSITIKGEQLHKDISFPKSVGLIIENMQLLPQYDAFTNLKILSKIKK IASDNDILDSISRVGLENFNSVKVSKFSLGMKQRLNIAQAIFEKPDILLLDEPTNAID EKGVAFVHDILLQEKKRGATIIITSHHKEDIISLCDIALEMNHGRLETSEKVIYKKDS *" gene 3962165..3962821 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" S_feature 3962822..3963136 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3963093 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" downshifts 3963137 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" downshifts complement(3963191) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" CDS complement(3963196..3963984) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" gene complement(3963196..3963984) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" promotor_-10 complement(3964008..3964026) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3964027) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" promotor_-35 complement(3964042..3964047) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3964052..3964441) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" gene complement(3964052..3964441) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" promotor_-35 3964510..3964513 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3964528..3964547 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3964541 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" CDS 3964587..3965426 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" gene 3964587..3965426 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" downshifts 3965403 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" CDS complement(3965459..3966673) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" gene complement(3965459..3966673) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" downshifts complement(3965477) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" S_feature complement(3966674..3966777) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3966770..3966789) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3966778..3966785 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3966780) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" promotor_-10 3966799..3966818 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3966803..3966810) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3966811 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" CDS 3966860..3967738 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" gene 3966860..3967738 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" CDS 3967752..3968195 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" gene 3967752..3968195 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" CDS 3968278..3968757 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " gene 3968278..3968757 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" downshifts 3968747 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" CDS complement(3968932..3969594) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" gene complement(3968932..3969594) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" CDS complement(3969741..3970193) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" gene complement(3969741..3970193) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" promotor_-35 3970217..3970224 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3970239..3970258 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3970241 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" S_feature 3970243..3970312 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3970246..3970265) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3970248) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" promotor_-35 complement(3970278..3970285) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3970313..3970759 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" gene 3970313..3970759 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" CDS 3970756..3971361 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" gene 3970756..3971361 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" CDS complement(3971456..3971977) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" gene complement(3971456..3971977) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" S_feature complement(3971978..3972805) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3972026..3972033 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3972047 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3972048..3972067 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3972113..3972387 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3972113 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" promotor_-35 3972116..3972121 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3972134..3972153 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3972388..3972744 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" gene 3972388..3972744 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" S_feature 3972745..3972903 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3972787..3972806) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3972805) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" promotor_-35 complement(3972821..3972828) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3972904..3973470 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" gene 3972904..3973470 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" CDS complement(3973977..3975353) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" gene complement(3973977..3975353) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" CDS complement(3975387..3975449) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" gene complement(3975387..3975449) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" promotor_-10 complement(3975470..3975489) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3975489) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" promotor_-35 complement(3975502..3975509) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3975637..3975643 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3975659..3975678 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3975665 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" CDS 3975702..3975941 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" gene 3975702..3975941 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" downshifts 3975950 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" promotor_-35 3976034..3976041 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3976057..3976076 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3976073 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" CDS 3976092..3976508 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" gene 3976092..3976508 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" CDS 3976505..3977422 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" gene 3976505..3977422 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" misc_feature 3977449..3977468 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3977459 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" promotor_-10 complement(3977463..3977482) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3977469) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3977494..3979563 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" gene 3977494..3979563 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" promotor_-35 complement(3977496..3977503) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3979527 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" CDS complement(3979560..3980459) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" gene complement(3979560..3980459) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" downshifts complement(3979603) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3980488..3980507) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3980504) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" S_feature complement(3980506..3981737) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3980522..3980529) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3980600..3980607 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3980621..3980640 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3980627 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" CDS 3980685..3982040 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" gene 3980685..3982040 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" promotor_-10 complement(3981723..3981742) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3981747) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" promotor_-35 complement(3981756..3981765) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3982074..3982628) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" gene complement(3982074..3982628) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" CDS complement(3982646..3983026) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" gene complement(3982646..3983026) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" CDS complement(3983082..3984017) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" gene complement(3983082..3984017) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" promotor_-35 3984007..3984016 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3984030..3984049 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3984037 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3984061..3984080) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3984075) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" CDS complement(3984076..3984834) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" gene complement(3984076..3984834) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" promotor_-35 complement(3984093..3984100) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3984367..3984870 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3984829 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" CDS complement(3984899..3985138) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" gene complement(3984899..3985138) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" downshifts complement(3984905) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" downshifts complement(3984973) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" CDS complement(3985182..3985700) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" gene complement(3985182..3985700) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" CDS complement(3985741..3986028) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" gene complement(3985741..3986028) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" S_feature complement(3986029..3986095) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3986094..3986113) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3986095) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" promotor_-35 complement(3986127..3986132) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3986139..3987239) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" gene complement(3986139..3987239) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" promotor_-10 complement(3987287..3987306) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3987302) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" promotor_-35 complement(3987321..3987328) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3987366..3989369) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" gene complement(3987366..3989369) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" CDS complement(3989420..3989626) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" gene complement(3989420..3989626) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" promotor_-10 complement(3989588..3989607) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3989613) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3989622..3989628) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3989652..3989671) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3989663) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" promotor_-35 complement(3989688..3989692) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3989720..3990736) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" gene complement(3989720..3990736) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" promotor_-10 complement(3990769..3990787) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3990781) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" promotor_-35 complement(3990803..3990808) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3990912) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" promotor_-35 3991096..3991101 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3991114..3991195 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3991114 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" promotor_-10 3991117..3991135 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3991196..3991813 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" gene 3991196..3991813 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" promotor_-35 3991784..3991792 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3991803 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" promotor_-10 3991806..3991824 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3991825 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3991852..3992700) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" gene complement(3991852..3992700) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" downshifts complement(3991872) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" CDS complement(3992693..3993454) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" gene complement(3992693..3993454) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" misc_feature complement(3993488..3993507) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3993506) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" upshifts complement(3993598) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" promotor_-10 complement(3993601..3993609) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3993623..3993631) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3993635..3993643 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3993651 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" promotor_-10 3993655..3993673 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3993702..3994142 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" gene 3993702..3994142 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" downshifts 3994091 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" CDS complement(3994193..3995044) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" gene complement(3994193..3995044) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" downshifts complement(3994212) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" S_feature complement(3995045..3995165) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3995166..3995885) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" gene complement(3995166..3995885) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" CDS complement(3995899..3997785) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" gene complement(3995899..3997785) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" CDS complement(3997806..3999185) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" gene complement(3997806..3999185) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" S_feature complement(3999186..3999316) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3999308..3999327) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3999316) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" promotor_-35 complement(3999343..3999347) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3999371..3999390) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3999381) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" promotor_-35 complement(3999404..3999411) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3999471..3999477 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3999482..4001767 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3999482 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" promotor_-10 3999492..3999511 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3999496..4000122) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" gene complement(3999496..4000122) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" downshifts complement(3999513) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" CDS complement(4000119..4000904) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" gene complement(4000119..4000904) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" promotor_-10 complement(4000949..4000968) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4000961) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(4000963..4001048) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(4000980..4000986) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(4001049..4001399) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" gene complement(4001049..4001399) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" S_feature complement(4001400..4001550) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(4001551..4001685) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" gene complement(4001551..4001685) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" promotor_no_box 4001709..4001809 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(4001721..4001740) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4001731) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(4001733..4001801) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(4001756..4001763) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 4001769..>4001902 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 4001769 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" promotor_-10 complement(4001787..4001806) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4001801) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" promotor_-35 complement(4001822..4001826) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" ORIGIN 1 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 61 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 121 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 181 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 241 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 301 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 361 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaaga tggaaaatat 421 attagacctg tggaaccaag cccttgctca aatcgaaaaa aagttgagca aaccgagttt 481 tgagacttgg atgaagtcaa ccaaagccca ctcactgcaa ggcgatacat taacaatcac 541 ggctcccaat gaatttgcca gagactggct ggagtccaga tacttgcatc tgattgcaga 601 tactatatat gaattaaccg gggaagaatt gagcattaag tttgtcattc ctcaaaatca 661 agatgttgag gactttatgc cgaaaccgca agtcaaaaaa gcggtcaaag aagatacatc 721 tgattttcct caaaatatgc tcaatccaaa atatactttt gatacttttg tcatcggatc 781 tggaaaccga tttgcacatg ctgcttccct cgcagtagcg gaagcgcccg cgaaagctta 841 caacccttta tttatctatg ggggcgtcgg cttagggaaa acacacttaa tgcatgcgat 901 cggccattat gtaatagatc ataatccttc tgccaaagtg gtttatctgt cttctgagaa 961 atttacaaac gaattcatca actctatccg agataataaa gccgtcgact tccgcaatcg 1021 ctatcgaaat gttgatgtgc ttttgataga tgatattcaa tttttagcgg ggaaagaaca 1081 aacccaggaa gaatttttcc atacatttaa cacattacac gaagaaagca aacaaatcgt 1141 catttcaagt gaccggccgc caaaggaaat tccgacactt gaagacagat tgcgctcacg 1201 ttttgaatgg ggacttatta cagatatcac accgcctgat ctagaaacga gaattgcaat 1261 tttaagaaaa aaggccaaag cagagggcct cgatattccg aacgaggtta tgctttacat 1321 cgcgaatcaa atcgacagca atattcggga actcgaagga gcattaatca gagttgtcgc 1381 ttattcatct ttaattaata aagatattaa tgctgatctg gccgctgagg cgttgaaaga 1441 tattattcct tcctcaaaac cgaaagtcat tacgataaaa gaaattcaga gggtagtagg 1501 ccagcaattt aatattaaac tcgaggattt caaagcaaaa aaacggacaa agtcagtagc 1561 ttttccgcgt caaatcgcca tgtacttatc aagggaaatg actgattcct ctcttcctaa 1621 aatcggtgaa gagtttggag gacgtgatca tacgaccgtt attcatgcgc atgaaaaaat 1681 ttcaaaactg ctggcagatg atgaacagct tcagcagcat gtaaaagaaa ttaaagaaca 1741 gcttaaatag caggaccggg gatcaatcgg ggaaagtgtg aataactttt cggaagtcat 1801 acacagtctg tccacatgtg gataggctgt gtttcctgtc tttttcacaa cttatccaca 1861 aatccacagg ccctactatt acttctacta ttttttataa atatatatat taatacatta 1921 tccgttagga ggataaaaat gaaattcacg attcaaaaag atcgtcttgt tgaaagtgtc 1981 caagatgtat taaaagcagt ttcatccaga accacgattc ccattctgac tggtattaaa 2041 attgttgcat cagatgatgg agtatccttt acagggagtg actcagatat ttctattgaa 2101 tccttcattc caaaagaaga aggagataaa gaaatcgtca ctattgaaca gcccggaagc 2161 atcgttttac aggctcgctt ttttagtgaa attgtaaaaa aattgccgat ggcaactgta 2221 gaaattgaag tccaaaatca gtatttgacg attatccgtt ctggtaaagc tgaatttaat 2281 ctaaacggac tggatgctga tgaatatccg cacttgccgc agattgaaga gcatcatgcg 2341 attcagatcc caactgattt gttaaaaaat ctaatcagac aaacagtatt tgcagtgtcc 2401 acctcagaaa cacgccctat cttgacaggt gtaaactgga aagtggagca aagtgaatta 2461 ttatgcactg caacggatag ccaccgtctt gcattaagaa aggcgaaact tgatattcca 2521 gaagacagat cttataacgt cgtgattccg ggaaaaagtt taactgaact cagcaagatt 2581 ttagatgaca accaggaact tgtagatatc gtcatcacag aaacccaagt tctgtttaaa 2641 gcgaaaaacg tcttgttctt ctcacggctt ctggacggga attatccaga cacaaccagc 2701 ctgattccgc aagacagcaa aacagaaatc attgtgaaca caaaagaatt ccttcaggcc 2761 attgatcgtg catctctttt agctagagag ggacgcaaca acgttgtaaa actgtccgca 2821 aaaccggctg aatccattga aatttcttcc aattcgccag aaatcggtaa agttgtggaa 2881 gcaattgttg cggatcaaat tgaaggtgag gaattaaata tctcttttag tccaaaatat 2941 atgctggatg cactaaaggt gcttgaagga gcagaaatac gcgtaagctt tacaggcgca 3001 atgagacctt tcttaattcg cacgccgaat gatgaaacga ttgtacagct tatccttcct 3061 gtcagaacct attaatccga tacactgctg ccgacccgtc ggcagctttt ctattcggta 3121 tctgctccga caagttttcc ctttccctaa ttcgtttttt tttagtacaa ttagatatta 3181 gtgatatttg aaagaggtcg atataatggc aaatccgatt tcaattgata cagagatgat 3241 tacactcgga caattcttaa aattagccga tgtgattcag tctggcggta tggcgaagtg 3301 gtttttaagc gagcatgaag tgcttgtgaa cgatgagccg gacaaccgcc ggggcagaaa 3361 gctgtatgtt ggagatgtgg tagagattga aggatttggt tcatttcaag tcgtcaatta 3421 aagcgggtga cactgattgt atatccagaa cttagaactg acatcttacc gcaactacga 3481 ccatgctgaa cttcaatttg aaaataaagt aaatgtgatc atcggagaaa acgcccaggg 3541 gaagacaaac ctcatggagg cgatctatgt cttgtccatg gcgaaatcgc accggacatc 3601 aaatgacaaa gaacttatac ggtgggacaa agactatgct aaaatagagg gaagagtgat 3661 gaagcaaaac ggggcgatcc cgatgcagct cgtcatctcc aaaaagggta aaaagggcaa 3721 ggtcaatcat attgaacagc aaaagctcag ccagtatgtc ggggccctca acaccattat 3781 gttcgcgccg gaagatttaa atcttgtaaa gggaagccct caagtgagaa ggcggtttct 3841 tgacatggaa atcggacagg tttctcccgt ctaccttcat gatctttctc tttaccagaa 3901 aatcctttcc cagcggaatc attttttgaa acagctgcaa acaagaaaac aaactgaccg 3961 gacgatgctc gatgttctga ccgatcagct tgtagaagtt gcagcaaaag tcgtcgtaaa 4021 acgcctgcag tttacagcac agctcgagaa atgggcgcag cccatccatg caggcatctc 4081 aagagggctt gaagaactga ccctgaaata ccatacagct cttgatgtat cagatcccct 4141 agatttgtcg aaaataggag atagctatca agaagcgttt tctaaattaa gagaaaaaga 4201 aattgagcgt ggtgtgacgc tgtcagggcc tcatcgcgat gatgttcttt tctatgtgaa 4261 cggacgcgat gtgcagacgt atggttctca aggacagcag cgaacgacgg cgttgtccct 4321 taagctggcg gagattgacc tgatccatga agaaatcgga gaatatccca ttttactatt 4381 ggatgatgta ctgagtgaac tggatgatta tcgccagtca cacttgcttc atacgatcca 4441 aggccgtgta caaacgtttg tcacaacgac aagcgttgat ggcattgatc acgaaacctt 4501 acgtcaagca ggaatgttcc gtgtgcaaaa tggtgcgtta gtgaagtgaa gaaatgaggt 4561 gagcaattgt atattcattt aggtgatgac tttgtggttt caacacgaga tattgtcggc 4621 atttttgact ttaaagccaa catgtcgcct attgttgaag aatttctgaa aaaacagaaa 4681 cacaaggtgg tgccttccgt aaacggcacg cccaaatcta tcgtagtcac ggttcagaat 4741 atatattact ctcccttatc ttccagcaca ttaaaaaaac gtgcgcaatt tatgtttgaa 4801 atagattctt agaaattttt tatcacgaat atatcgttta gaaaagtgta ggtgaatgac 4861 gtggctatgg aacagcagca aaacagttat gatgaaaatc agatacaggt actagaagga 4921 ttggaagctg ttcgtaaaag accggggatg tatatcggtt cgacaaacag caaaggcctt 4981 caccacttgg tatgggaaat tgtcgacaat agtattgacg aagccctcgc cggttattgt 5041 acggatatca atatccaaat cgaaaaagac aacagtatca cggttgtaga taatggccgc 5101 ggtattccag tcggtattca tgaaaaaatg ggccgtcctg cggtagaagt cattatgacg 5161 gtgcttcatg ccggaggaaa atttgacgga agcggctata aagtatccgg aggattacac 5221 ggtgtaggtg cgtcggtcgt aaacgcacta tcaacagagc ttgatgtgac ggttcaccgt 5281 gacggtaaaa ttcaccgcca aacctataaa cgcggagttc cggttacaga ccttgaaatc 5341 attggcgaaa cggatcatac aggaacgacg acacattttg tcccggaccc tgaaattttc 5401 tcagaaacaa ccgagtatga ttacgatctg cttgccaacc gcgtgcgtga attagccttt 5461 ttaacaaagg gcgtaaacat cacgattgaa gataaacgtg aaggacaaga gcgcaaaaat 5521 gaataccatt acgaaggcgg aattaaaagt tatgtagagt atttaaaccg ctctaaagag 5581 gttgtccatg aagagccgat ttacattgaa ggcgaaaagg acggcattac ggttgaagtg 5641 gctttgcaat acaatgacag ctacacaagc aacatttact cgtttacaaa caacattaac 5701 acgtacgaag gcggtaccca tgaagctggc ttcaaaacgg gcctgactcg tgttatcaac 5761 gattacgcca gaaaaaaagg gcttattaaa gaaaatgatc caaacctaag cggagatgac 5821 gtaagggaag ggctgacagc gattatttca atcaaacacc ctgatccgca gtttgagggc 5881 caaacaaaaa caaagctggg caactcagaa gcacggacga tcaccgatac gttattttct 5941 acggcgatgg aaacatttat gctggaaaat ccagatgcag ccaaaaaaat tgtcgataaa 6001 ggtttaatgg cggcaagagc aagaatggct gcgaaaaaag cgcgtgaact aacacgccgt 6061 aagagtgctt tggaaatttc aaacctgccc ggtaagttag cggactgctc ttcaaaagat 6121 ccgagcatct ccgagttata tatcgtagag ggtgactctg ccggaggatc tgctaaacaa 6181 ggacgcgaca gacatttcca agccattttg ccgcttagag gtaaaatcct aaacgttgaa 6241 aaggccagac tggataaaat cctttctaac aacgaagttc gctctatgat cacagcgctc 6301 ggcacaggta tcggagaaga cttcaacctt gagaaagccc gttaccacaa agttgtcatt 6361 atgacagatg ccgatgttga cggcgcgcac atcagaacac tgctgttaac gttcttttac 6421 agatatatgc gccaaattat cgaaaatggc tacgtgtaca ttgcgcagcc gccgctctac 6481 aaggttcaac aggggaaacg cgttgaatat gcatacaatg acaaggagct tgaagagctg 6541 ttaaaaactc ttcctcaaac gcctaagcct ggactgcagc gttacaaagg tcttggtgaa 6601 atgaatgcca cccagctatg ggagacaacc atggatccta gctccagaac acttcttcag 6661 gtaactcttg aagatgcaat ggatgcggat gagacttttg aaatgcttat gggcgacaag 6721 gtagaaccgc gccgaaactt catagaagcg aatgcgagat acgttaaaaa tcttgacatc 6781 taatcataaa aagccttatt tccaataaga aataaggctt ttttctgaac aagatcagat 6841 gcagcgatgc ctgcaatacc tatatattct agcaatttaa tgtgtataat cataagttta 6901 ttgatataat ggagaatagt gaaatcgtat tgaaggtcat aatggacaat ctactcccac 6961 atatttcatg tgatacttca gggaggtttt ttaatgagtg aacaaaacac accacaagtt 7021 cgtgaaataa atatcagtca ggaaatgcgt acgtccttct tggattatgc aatgagcgtt 7081 atcgtgtccc gtgctcttcc ggatgttcgt gacggtttaa aaccggttca tagacggatt 7141 ttgtatgcaa tgaatgattt aggcatgaca agtgacaagc cttataaaaa atccgcgcgt 7201 atcgttggag aagttatcgg gaaataccac ccgcacggtg attcagcggt atatgaatcc 7261 atggtcagaa tggctcagga tttcaactac cgttatatgc tcgttgacgg tcacggaaac 7321 ttcggttctg ttgacggaga ctcagcggcg gccatgcgtt atacagaagc acgaatgtct 7381 aaaatctcaa tggagattct tcgcgacatc acaaaagaca caatcgatta ccaggataac 7441 tatgacgggt cagaaagaga acctgtcgtt atgccttcaa ggttcccgaa tctgctcgtg 7501 aacggtgctg ccggcattgc ggtaggtatg gcaacaaaca ttcctccgca ccagctggga 7561 gaaatcattg acggtgtact tgctgttagt gagaatccgg acattacaat tccagagctt 7621 atggaagtca ttccagggcc tgatttcccg accgcgggtc aaatcttggg acgcagcggt 7681 atccggaaag catacgaatc aggccgaggc tctatcacga tccgggcaaa agctgagatc 7741 gaacaaacat cttcgggtaa agaaagaatt atcgttacag agttacctta ccaagtaaat 7801 aaggcgaaat taattgagaa aattgctgat ctcgtaaggg acaaaaagat agagggtatc 7861 acagatctgc gtgatgagtc agatcgtaca ggtatgagaa ttgtcattga aatcagacgc 7921 gatgccaatg cgaatgttat cttaaacaat ctgtacaaac aaactgctct acaaacatct 7981 tttggcatca acctgcttgc gcttgttgat ggccagccga aagttttaac tcttaagcaa 8041 tgcctggagc attaccttga ccatcaaaaa gttgtcatta gacgccgtac tgcttatgaa 8101 ttgcgtaaag cagaagcgag agctcatatc ttggaaggat tgagagttgc actggatcat 8161 ctcgatgcag ttatctccct tatccgtaat tctcaaacgg ctgaaattgc gagaacaggt 8221 ttaattgaac aattctcact gacagagaag caagcacaag cgatccttga catgaggctc 8281 cagcgtttaa cgggactgga acgtgaaaag atcgaagaag aataccagtc tcttgttaaa 8341 ttaattgcag agctaaaaga catcttggca aatgaatata aagtgcttga gatcattcgt 8401 gaagaactca cggaaatcaa agagcgtttt aacgatgaaa gacgtactga gatcgtcact 8461 tctggactgg agacaattga agatgaagat ctcatcgaga gagaaaatat cgtagttact 8521 ctgacgcaca acggatacgt caaacgtctt cctgcatcaa cttaccgcag tcaaaaacgg 8581 ggcggaaaag gtgtacaagg tatgggaaca aacgaagatg atttcgttga acatttgatc 8641 tctacgtcaa ctcatgacac gattctcttc ttctcgaaca aggggaaagt gtatcgtgca 8701 aaagggtatg aaatccctga atacggcaga acggcaaaag gaatcccgat tattaacctg 8761 ctggaggtag aaaagggtga gtggatcaac gcgattattc cagtcacgga attcaatgcg 8821 gagctttacc tcttcttcac tacaaagcat ggggtttcaa aacgaacatc gctatctcaa 8881 ttcgctaata tccgcaacaa tggtctaatt gctctgagtc ttcgtgaaga tgatgaactg 8941 atgggtgtac gtctgactga cggcacaaaa caaatcatca ttggaacgaa aaacggttta 9001 ctgattcgtt tccctgaaac agatgtccga gagatgggaa gaactgcggc gggcgtaaaa 9061 ggcatcaccc tgacggatga cgacgttgtt gtcggcatgg agattttaga ggaagaatca 9121 cacgtcctta tcgtaactga aaaagggtac ggaaaacgaa ctcctgctga agagtacaga 9181 acccaaagcc ggggcggaaa aggactcaaa acagcgaaaa tcaccgagaa caacggccaa 9241 ctagtagcag tgaaagctac taaaggtgaa gaggatctaa tgattattac agctagcggc 9301 gtactcatca gaatggacat caatgatatc tccatcaccg gacgtgtcac tcaaggtgtg 9361 cgtctcatca gaatggcaga agaagagcat gttgctacag tagctttagt tgagaaaaac 9421 gaagaagatg agaatgaaga agaacaagaa gaagtgtgaa aaaaagcgca gctgaaatag 9481 ctgcgctttt ttgtgtcata accctttaca gtcataaaaa ttatggtata atcatttctg 9541 ttgtcttttt aaagacacaa gcatgaccat tatgactagt aaaaactttt tcaaaaaagt 9601 attgacctag ttaactaaaa atgttactat taagtagtcg ctttgagaga agcacacaaa 9661 gttctttgaa aactaaacaa gacaaaacgt acctgttaat tcatttttat aaatcgcaca 9721 gcgatgtgcg tagtcagtca aactagggcc tgcacgacgc aggtcacaca ggtgtcgccg 9781 caggatgcgg tgaacttaac ctgtgatcca tttatcggag agtttgatcc tggctcagga 9841 cgaacgctgg cggcgtgcct aatacatgca agtcgagcgg acagatggga gcttgctccc 9901 tgatgttagc ggcggacggg tgagtaacac gtgggtaacc tgcctgtaag actgggataa 9961 ctccgggaaa ccggggctaa taccggatgg ttgtttgaac cgcatggttc aaacataaaa 10021 ggtggcttcg gctaccactt acagatggac ccgcggcgca ttagctagtt ggtgaggtaa 10081 cggctcacca aggcgacgat gcgtagccga cctgagaggg tgatcggcca cactgggact 10141 gagacacggc ccagactcct acgggaggca gcagtaggga atcttccgca atggacgaaa 10201 gtctgacgga gcaacgccgc gtgagtgatg aaggttttcg gatcgtaaag ctctgttgtt 10261 agggaagaac aagtgccgtt cgaatagggc ggtaccttga cggtacctaa ccagaaagcc 10321 acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt gtccggaatt 10381 attgggcgta aagggctcgc aggcggtttc ttaagtctga tgtgaaagcc cccggctcaa 10441 ccggggaggg tcattggaaa ctggggaact tgagtgcaga agaggagagt ggaattccac 10501 gtgtagcggt gaaatgcgta gagatgtgga ggaacaccag tggcgaaggc gactctctgg 10561 tctgtaactg acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta 10621 gtccacgccg taaacgatga gtgctaagtg ttagggggtt tccgcccctt agtgctgcag 10681 ctaacgcatt aagcactccg cctggggagt acggtcgcaa gactgaaact caaaggaatt 10741 gacgggggcc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 10801 taccaggtct tgacatcctc tgacaatcct agagatagga cgtccccttc gggggcagag 10861 tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 10921 acgagcgcaa cccttgatct tagttgccag cattcagttg ggcactctaa ggtgactgcc 10981 ggtgacaaac cggaggaagg tggggatgac gtcaaatcat catgcccctt atgacctggg 11041 ctacacacgt gctacaatgg acagaacaaa gggcagcgaa accgcgaggt taagccaatc 11101 ccacaaatct gttctcagtt cggatcgcag tctgcaactc gactgcgtga agctggaatc 11161 gctagtaatc gcggatcagc atgccgcggt gaatacgttc ccgggccttg tacacaccgc 11221 ccgtcacacc acgagagttt gtaacacccg aagtcggtga ggtaaccttt taggagccag 11281 ccgccgaagg tgggacagat gattggggtg aagtcgtaac aaggtagccg tatcggaagg 11341 tgcggctgga tcacctcctt tctaaggata ttttacggaa tataagacct tgggtcttat 11401 aaacagaacg ttccctgtct tgtttagttt tgaaggaact ttgttccttg aataagttaa 11461 gatgggcctg tagctcagct ggttagagcg cacgcctgat aagcgtgagg tcggtggttc 11521 gagtccactc aggcccacca tcttatataa cggggcctta gctcagctgg gagagcgcct 11581 gctttgcacg caggaggtca gcggttcgat cccgctaggc tccaccaacg tgttctttga 11641 aaactagata acagtagaca tcacattcaa ttagtaacac aagatatcac atagtgattc 11701 tttttaacgg ttaagttaga aagggcgcac ggtggatgcc ttggcactag gagccgatga 11761 aggacgggac gaacaccgat atgcttcggg gagctgtaag caagctttga tccggagatt 11821 tccgaatggg gaaacccacc actcgtaatg gagtggtatc catatctgaa ttcataggat 11881 atgagaaggc agacccgggg aactgaaaca tctaagtacc cggaggaaga gaaagcaaat 11941 gcgattccct gagtagcggc gagcgaaacg ggatcagccc aaaccaagag gcttgcctct 12001 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 12061 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 12121 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 12181 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 12241 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 12301 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 12361 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 12421 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 12481 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 12541 ccaatcgaac ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 12601 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 12661 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 12721 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 12781 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 12841 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 12901 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 12961 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 13021 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 13081 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 13141 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 13201 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 13261 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 13321 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 13381 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 13441 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 13501 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 13561 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 13621 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 13681 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 13741 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 13801 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 13861 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 13921 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtgtca ggtgggcagt 13981 ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc cctcagaatg 14041 gttggaaatc attcgcagag tgtaaaggca caagggagct tgactgcgag acctacaagt 14101 cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgcatggaag ggccatcgct 14161 caacggataa aagctacccc ggggataaca ggcttatctc ccccaagagt ccacatcgac 14221 ggggaggttt ggcacctcga tgtcggctca tcgcatcctg gggctgtagt cggtcccaag 14281 ggttgggctg ttcgcccatt aaagcggtac gcgagctggg ttcagaacgt cgtgagacag 14341 ttcggtccct atccgtcgcg ggcgcaggaa atttgagagg agctgtcctt agtacgagag 14401 gaccgggatg gacgcaccgc tggtgtacca gttgttctgc caagggcatc gctgggtagc 14461 tatgtgcgga cgggataagt gctgaaagca tctaagcatg aagcccccct caagatgaga 14521 tttcccattc cgcaaggaag taagatccct gaaagatgat caggttgata ggtctgaggt 14581 ggaagtgtgg cgacacatgg agctgacaga tactaatcga tcgaggactt aaccatattt 14641 ttgaatgatg tcacacctgt tatctagttt tgagagaaca ctctcaattt gtttggtggc 14701 gatagcgaag aggtcacacc cgttcccata ccgaacacgg aagttaagct cttcagcgcc 14761 gatggtagtc gggggtttcc ccctgtgaga gtaggacgcc gccaagcaag cttaaaccca 14821 gctcaatgag ctgggttttt tgtttgttaa aaatgaagaa gaaactgtga agcgtattta 14881 gggaatttct tttctgatac taataaaaac tgctgaatta acacgtagtc atcacttata 14941 tgctgtgtta ataactcata ccaccattct gtttcatacc ttgcaatcat cccaacgttg 15001 tacaaaatca aataatgaat tgtcatttcg ggaagcctca gaaattgctc cctttgagaa 15061 gggatataat attggttctt ttccatgtca aacaataagc tggtcgatgt ccatggctcc 15121 ttgtcttgtg gtgaaatttc gaacagcagc ccgtgttcat ttttttttgt aaaagaccat 15181 tgataatgat gggacatgta ttcagcaaac cttgaatcag acattttgta attgattact 15241 acttcctccg gtacaaaaat ttcgttctta tccttctcaa cttttgtcat aaatcgttct 15301 ttctgctgaa agtagaaaat atcgctaagt tctggaatgg ccattaataa ttttttcatg 15361 gtataccgtt catctactat atccgattgt ccgaataaat gtttcataaa atgtacgcat 15421 aggccattcc gttgtatttt cacttcatcg tcgctaaaac aataattttg tttctttcgt 15481 tttcttgttg ttacgccatg tgccagtact gatgtatggc ttggataatg aggatcacgt 15541 gtaattaagc atgctttgat aagctgtgcc attccataaa ataaaagaat cggtttgatt 15601 tctaagggag aatatgcggc ttgtttataa aacgattcgg catgctttaa gaaataaata 15661 aaccgttcac tgtttttaaa agagtttttt ttcgcatcgt taataccgtt taagatataa 15721 accttttcta gaaatttctg ggttgattca acggagtaaa atagcgctaa gtctttccac 15781 tcatgatatg tcatgtatat ttcttaatcc tttccgttat ctaaatattt caactctttc 15841 ccgcttcctt gacatgctct tggctagttg ataatctaca tataatattt tgccgaaaag 15901 agggggattt actaatgtgg gaaagtaaat tttcaaaaga aggcttaacg ttcgacgatg 15961 tgctgcttgt accagcaaag tctgaggtac ttccgcgtga tgtggattta tctgtagaac 16021 ttacaaaaac gttaaagcta aatattcctg tcatcagcgc aggtatggac actgtaacag 16081 aatcagcaat ggcaattgca atggcaagac agggcggctt gggcatcatt cacaaaaata 16141 tgtccattga acagcaggct gaacaagttg ataaagtaaa gcgttctgag cgcggcgtta 16201 tcacaaatcc cttcttttta actcctgatc accaagtatt tgatgcggag catttgatgg 16261 ggaaatacag aatttccggt gttccgattg taaataacga agaagaccag aagcttgttg 16321 gaattattac aaaccgtgac cttcgtttta tttctgacta ctcaatgaaa atcagcgacg 16381 tcatgacgaa agaagagcta gttactgcat ctgtaggaac tactctggat gaagctgaaa 16441 agattttgca gaaacataaa attgaaaagc ttcctctcgt agatgaccag aataaattaa 16501 aaggtcttat cacaattaaa gacattgaaa aagtcattga gttcccgaac tcatctaaag 16561 acattcacgg ccgcctgatc gttggcgcgg cagttggtgt aactggcgat acaatgactc 16621 gcgtcaaaaa gcttgttgaa gccaatgttg atgtgattgt tatcgataca gctcacggac 16681 actctcaagg cgttttaaac acagtcacaa aaatccgtga aacgtatccc gaattaaaca 16741 ttattgctgg aaacgtggca acagctgaag cgacaagagc gcttatcgaa gctggagcag 16801 acgttgtcaa agttggaata gggcctggtt caatttgtac tacacgtgtt gtagccggcg 16861 tgggtgttcc gcaaattaca gcaatttatg attgtgcgac tgaagcaaga aaacacggca 16921 aaacaatcat cgccgacggt gggattaaat tctctggcga tatcactaaa gcattggcag 16981 ccggcggaca tgctgttatg ctcggaagct tgcttgcagg cacatcagaa agccctggtg 17041 aaactgaaat ctaccaaggc agaagattta aggtataccg cggcatggga tcagttgctg 17101 caatggaaaa aggaagtaaa gaccgttact tccaagaaga aaacaaaaaa tttgttcctg 17161 aaggaattga aggacgcaca ccttacaaag ggccagttga agaaaccgtt tatcagctag 17221 tcggaggcct tcgttctggt atggggtatt gcgggtccaa agatctgcgt gcgctaagag 17281 aagaagctca gttcattcgc atgactggcg caggacttcg cgaaagccat ccgcatgacg 17341 tacagattac aaaagaatca cctaactata caatttcata ataaattgtt acaaattaaa 17401 aacatttgac agggtctctg actctgtcta ttttttttat actgattatg ataaaattta 17461 tactgttgtg cattgaaaat gtccttaacg gcttaattat agatgaagaa aatgaaatac 17521 ggaggtcgta cgattgaaca tcaagaaatg taaacagcta ctgatgtcat tggttgtgtt 17581 aactctagct gtcacgtgtc tggctccaat gtcaaaagcg aaagcagcca gcgatccaat 17641 tgatatcaat gcatctgctg ctattatgat cgaagcttct tcaggtaaaa ttctttacag 17701 taaaaatgca gataagagac tgccaattgc gagtatgaca aaaatgatga cagagtatct 17761 gttattggaa gcaattgatc aaggtaaagt gaaatgggac caaacctata cgcctgatga 17821 ctatgtgtat gaaatttccc aagataacag cttatcaaac gttcctcttc ggaaagacgg 17881 gaaatacaca gtaaaagaat tatatcaagc tacagcaatt tattctgcaa atgctgctgc 17941 tattgcgatt gcagaaatcg ttgccggttc tgaaactaag tttgttgaaa aaatgaatgc 18001 aaaagcaaaa gaactaggct taacagatta caaatttgtt aacgcaacag gtcttgaaaa 18061 caaagatctt cacgggcatc agcctgaggg gacaagcgta aatgaagaaa gtgaagtttc 18121 tgcaaaggat atggcggttc ttgcggatca cttgattact gactaccctg agatactgga 18181 gacttccagt atcgccaaaa cgaaattcag agaaggcacc gatgatgaaa tggacatgcc 18241 gaactggaat tttatgctga aggggcttgt cagcgagtat aaaaaagcga ctgtagacgg 18301 actgaaaaca ggttctactg actctgcggg ttcatgcttt acaggaacag ctgaacgcaa 18361 cggtatgcgt gtcatcactg ttgttttaaa cgcaaagggc aaccttcata caggccgttt 18421 cgatgaaacg aaaaaaatgt ttgattatgc tttcgacaat ttctccatga aagaaattta 18481 tgctgaaggc gatcaagtaa aaggccataa aacaatttca gttgataagg gtaaagagaa 18541 agaagtaggc attgtgacaa acaaggcgtt ctctcttcct gtcaaaaatg gtgaagaaaa 18601 gaattacaaa gcgaaggtca cactgaataa agacaactta actgctcctg tgaaaaaagg 18661 aaccaaggtt gggaagctga ctgcggaata cacaggtgat gaaaaggatt acggattcct 18721 taacagcgat ctggctggcg tagaccttgt tacaaaagaa aatgtagaaa aagcaaactg 18781 gtttgttttg acaatgcgca gtatcggcgg attttttgcc ggaatttggg gaagcattgt 18841 tgatacggta accggctggt tttaatcaat tgaaagagct ctgatggatg ttagggctct 18901 ttcgcgtaat atactgaaaa aacccaattt ttaataaaaa atgattttca aagcgctaaa 18961 aaccgaataa aatagtatat atgcatatga attattggat ttctaggata caataaggat 19021 tagaaatcat ataactatac cttgattagg gggaccaaga aatggctcaa acaggtactg 19081 aacgtgtaaa acgcggaatg gcagaaatgc aaaaaggcgg cgtcatcatg gacgtcatca 19141 atgcggaaca agcgaaaatc gctgaagaag ctggagctgt cgctgtaatg gcgctagaac 19201 gtgtgccagc agatattcgc gcggctggag gagttgcccg tatggctgac cctacaatcg 19261 tggaagaagt aatgaatgca gtatctatcc cggtaatggc aaaagcgcgt atcggacata 19321 ttgttgaagc gcgtgtgctt gaagctatgg gtgttgacta tattgatgaa agtgaagttc 19381 tgacgccggc tgacgaagaa tttcatttaa ataaaaatga atacacagtt ccttttgtct 19441 gtggctgccg tgatcttggt gaagcaacac gccgtattgc ggaaggtgct tctatgcttc 19501 gcacaaaagg tgagcctgga acaggtaata ttgttgaggc tgttcgccat atgcgtaaag 19561 ttaacgctca agtgcgcaaa gtagttgcga tgagtgagga tgagctaatg acagaagcga 19621 aaaacctagg tgctccttac gagcttcttc ttcaaattaa aaaagacggc aagcttcctg 19681 tcgttaactt tgccgctggc ggcgtagcaa ctccagctga tgctgctctc atgatgcagc 19741 ttggtgctga cggagtattt gttggttctg gtatttttaa atcagacaac cctgctaaat 19801 ttgcgaaagc aattgtggaa gcaacaactc actttactga ttacaaatta atcgctgagt 19861 tgtcaaaaga gcttggtact gcaatgaaag ggattgaaat ctcaaactta cttccagaac 19921 agcgtatgca agaacgcggc tggtaagaac ataggagcgc tgctgacatg ttaacaatag 19981 gtgtactagg acttcaagga gcagttagag agcacatcca tgcgattgaa gcatgcggcg 20041 cggctggtct tgtcgtaaaa cgtccggagc agctgaacga agttgacggg ttgattttgc 20101 cgggcggtga gagcacgacg atgcgccgtt tgatcgatac gtatcaattc atggagccgc 20161 ttcgtgaatt cgctgctcag ggcaaaccga tgtttggaac atgtgccgga ttaattatat 20221 tagcaaaaga aattgccggt tcagataatc ctcatttagg tcttctgaat gtggttgtag 20281 aacgtaattc atttggccgg caggttgaca gctttgaagc tgatttaaca attaaaggct 20341 tggacgagcc ttttactggg gtattcatcc gtgctccgca tattttagaa gctggtgaaa 20401 atgttgaagt tctatcggag cataatggtc gtattgtagc cgcgaaacag gggcaattcc 20461 ttggctgctc attccatccg gagctgacag aagatcaccg agtgacgcag ctgtttgttg 20521 aaatggttga ggaatataag caaaaggcac ttgtataaaa cagttgaaag ctgtggaaac 20581 ttatagtaca ttataagcac aaataaagat cgaaaagcgt tgataggaac tagtagggag 20641 cctctctttc taagagagcc gatggttggt gcgaatcggt gaaagatgct gtctgaatcc 20701 atccttgagc gaaatgctga agcgagtagg catttacggg ataaccgtta tgtttgaaag 20761 tggaaaacga gtctttgatt tgttttcaat cagggtggca acgcgagagc tctcgtccct 20821 ttatggggat gagggctctt tttattttcg ataaatcaat aaaaaaagga gtgtttcgca 20881 tgcttgatac gaaaatgctg agagcaaatt ttcaagaaat taaagcaaag cttgtacaca 20941 aaggcgaaga cttaactgat tttgataagt ttgaggcgct ggatgataga cgaagagagc 21001 ttatcggcaa ggttgaagag ttaaaaggaa aacgaaatga agtttctcag caggttgctg 21061 tgctgaagcg tgagaaaaaa gacgcggatc acattattaa agaaatgcgt gaagtcggcg 21121 aggaaattaa aaagctcgat gaagaattac ggacagtgga agctgagctt gatacaatcc 21181 tgctctcaat cccgaatatt ccgcatgagt ctgtacctgt cggtgaaaca gaagacgaca 21241 acgtagaagt gcgtaaatgg ggtgaaaagc cttcatttgc ttatgagccg aagccgcact 21301 gggatattgc ggatgagctg ggtattctgg attttgaacg tgctgccaaa gtaacaggaa 21361 gccgtttcgt gttctataaa ggcttaggtg ctcgtctgga gcgtgcgctt tataacttta 21421 tgcttgatct gcatgtggat gagtataact acactgaagt gatcccgcca tatatggtaa 21481 accgcgcaag catgacggga acggggcagc ttcctaaatt tgaagaggat gcatttaaaa 21541 tcagagaaga agattatttc ttaattccaa cggcggaagt gccgattaca aacatgcatc 21601 gcgatgaaat cctttcaggt gacagcctgc cgatcaacta tgcggcattc agtgcttgct 21661 tccgttctga agctggttca gcaggacgtg acacacgcgg attaattcgt cagcaccaat 21721 ttaataaagt tgagcttgta aagtttgtga agcctgaaga ttcttatgaa gaattagaga 21781 aacttacaaa ccaagcagaa cgggttcttc agctgcttga gcttccatac cgtgtcatga 21841 gcatgtgtac gggtgactta ggctttacgg ctgcgaaaaa atacgatatc gaagtttgga 21901 ttccaagcca agacacatat cgagaaatct cttcttgcag caacttcgaa gcgttccagg 21961 cgagacgtgc gaatattcgt ttcagacgtg aagcgaaagg caagcctgag catgtacaca 22021 cactgaacgg ctcaggactg gcggttggaa gaacagttgc tgctatctta gaaaattatc 22081 agcaggaaga cggaagcgtt gtgattccga aagtgcttcg tccttatatg gggaatagag 22141 aagtaatgaa accgtaaatt atggaaaggc gtgcctgaca aggtgcgcct ttttgcttat 22201 gtaaacacgg cattttcata aaaacaaaaa aagtttttaa aaatgcttga ccacacgaga 22261 acatacgtga tatagttagt cttgtcgata cggaggaata cccaagtccg gctgaaggga 22321 tcggtcttga aaaccgacag gggtgtcaaa gcccgcgggg gttcgaatcc ctcttcctcc 22381 gccatattga ttttaattct aatgaaacac aagcatatat tggagattgt tttgtccgtt 22441 gcattcggtg cggcggattt tttattttaa agaaaaagtg aatctcgact gagattcact 22501 ttttttgatt atcatgaata actgaagcaa tttgatctac aatattttca atcgagtttt 22561 cgtcgttcag aagatcataa tcttcaatgc gaagttttaa aacagggcag gcattaaaac 22621 cgcttatcca gttctcgtag cgtgtatgca tttcttccca ataagaccgg cttgtctgaa 22681 gctccatctc acggccgcgt tgttcaatcc ggtttaaaat gttctccaga tctccttcta 22741 aatagatcaa cacatctgga tgtgggaaat acggtgtcat taccattgct tcgaaaaggc 22801 ttgtgtaagt cttataatca acctttgaca ttgtcccttt atcagcatgc atttttgcga 22861 aaattcctgt atcttcataa atcgaacgat cctgtacaaa acctccgccg gcttcaaaaa 22921 ttgttttctg ttctttgaag cgttcagcta agaagtaaat ttgaaggtga aagctccaac 22981 gttcaaaatc atgatagaac ttttccaaat atggattatg atcgacttcc tccaacgatg 23041 ttttaaatcc aagccgttta gctaaagttt ttgttaaagt cgattttccg acacctactg 23101 ttcctgctac tgtaataatt gaattcttag ggatatgatg ttccttcata cgataagctc 23161 ctttacatgg gcggcaatgc gttcaaagtc gctcttattc aaaacgaaat cctttgaatc 23221 accatctacg gttaacactg taagttcagg gtctgcttcc tgcagctgct tgatggcgac 23281 ttcataatct gaaatcagct gctccaaata gctagtttca atttttttct caaaggggcg 23341 cccgcgtttt tcaatgcggt gtagcaatgt aggcagactg gcctttatgt aaatgatgaa 23401 attcggcttt ggcagatcat ccgttagcag gtgatatatc tttttgtatt tttccagctg 23461 atgtggagac aaggttcgtt ccgcaaaaat cacattttta taaatatgat aatcagctat 23521 tacaggctgt ccctttttta aaaagtgatc actggtgtct tcaagctgtt tgtatctgtg 23581 acaaagaaaa aacatctcga gctggaagct ccattccttt atattgtcat aaaacttatc 23641 aaggtacggg ttatcctcta caatctcatt gatcataggg aatccgaatt tttgtgagag 23701 catcgttgcg agagttgttt ttcctgcccc gataggacct tctattgcaa taaaaggggc 23761 tgtattcatc ggaatcctcc ttatatctga aaaacgtgcg tcagttaccg accttcatat 23821 tgtatcacaa cccttgggtg cccccatgaa aaaaagacgt ttccaaatta tcgaaacgtc 23881 tttttgacaa cattaaattg atcagacagc agcagccagt tttgtggaaa ggaaagaccc 23941 agcttccaat agctgatgcc tcttaaattc agctctttaa tcagattgaa ttttgcttga 24001 atcgagcggg catcctcgaa ccatacctcg tgccttctgt tttctgcatc agtatagcgg 24061 aagaaaggag cttgagcggt ttggtcatac tgaatggaag cattgttctg atcagctatg 24121 acaatggctt gctgagggct tactgctctt gctggagttc cccctgctgt atatggcagc 24181 gtccagtcat atccatataa attctggccc atgacaattt tgttcgcagg catttcagtc 24241 aaagcatatt ctatgacatc acggacaggt ccaattggag aaaccgcttg aggcggtccg 24301 ccgctatagc cccattcata tgtcatgaga acaacaaagt cgacaatttc gccatgtgcc 24361 ctgtaatcat gagcttcata ccacctgccc tgctgtgttg cacttgtttt aggagcaaga 24421 gccgtagaaa tttctaagcc ctctcgatgg aaaagatccc ttgcttcgcg gaggaattga 24481 ttataggcct ctctatcctg gggccgcaaa tattcaaagt cgaaatgaat gtcacggaag 24541 ccatatcttc tggcattctc gactatttca tttagaagcc gtctttttac agtttcgtcg 24601 ttcaaaagga tccggccaag ttcatcgctg aatgcctggt tttctaggtt cgttataatc 24661 atcatcaatg ttgtattttg actttctgta atgctcctta aattcgttaa aggcggtgcg 24721 actaaggttc cgttccgctg tgcctggaag ctgaatgcgc caaggtaagt taagtagggc 24781 gacgcttctc tggccgcctg ctggagattt tcgctgactt gatttcctcg gggctccaaa 24841 taagcatttg attcgatgtc tcgtttagga gctggaggga tgtataaacg gaaaccaatc 24901 tgaagcacgg tatttaactg gatgcggtta acccttgcga gctcggctgc tgttgtattg 24961 aactgccggg cgatggatgt cagggtatca cctcgcttca catcatagaa ctggccagct 25021 attggaatga caatggtttg tccgacaaca aggctgtcgg gattcggtat ttcattcgtt 25081 tcagtgatgt catttgtggt tgttctgtat tgtgaagcga tagcagaaag agtgtcgcct 25141 tgttttacca cataaatttg aatgaaaaac gcctcctttc atatcgctat caatgtatga 25201 aagaaaagcg ctgatcatgt ttatttttct ataatttgtt cttccgtcgt aatttctgcg 25261 aaaagaacat tctccatcat ggttaaggcg aattcgttat cttcgtcact gtttgacgcg 25321 atacagtcct taggaatcgt gatgctgtat tccctcatat aagcgtcatt agcggtaaac 25381 agcacgcata tattgccggc tatacctgtt atgataatat gtctcacctg caactcagta 25441 agaagggtgt gaagtgctgt ttcgtagaaa gcggaatgtt tcggtttgat taaaaaataa 25501 tcagcatcta ccggagctat ctttgtgatg atatccttgc ttctttcatt tgtgcattct 25561 tgctgtatgt ttttaatgtc agcttgccaa agtccataat gatcattgat gtaaataatc 25621 ggccattcat tttgtctcgc gtgctccttt aatgataaaa tatgaggaac gattttttct 25681 gtttttttag cgagggtttc ccccatatcg aattcaaaat tattgatcat gtctacaatg 25741 agaagggctt tatctgcttt ggacaatcga cagtctcctt tccgtttcag ttatagttaa 25801 tatgtagcct ttttaggcaa tgaaaaaact ttgaaaagag agcttatcct tatgacacaa 25861 gatgaacttt atatgaaaga agcaattaaa gaagcgaaaa aggctgaaga gaaaggtgaa 25921 gtgccaatag gtgcggtgct tgtcattaat ggtgaaatta tagcgcgtgc gcataattta 25981 agagagactg aacagcgatc tattgcccat gcagaaatgc ttgtaattga tgaagcgtgt 26041 aaggcactcg gaacatggcg gctggaaggt gcgactcttt atgtgacgct tgagccttgt 26101 ccaatgtgtg ctggtgcagt cgtactttct cgagtggaaa aagtggtttt tggcgcattt 26161 gatccgaaag gcggctgttc aggcacgcta atgaaccttc ttcaggagga acgctttaat 26221 catcaggctg aagtggtgag cggtgtgctt gaggaagaat gcggcggaat gctcagtgcg 26281 tttttcagag aactaagaaa aaagaagaaa gccgccagga aaaacttgtc tgaatagtac 26341 ggttgcaatt tttaggggaa acagatatac ttaagtgtgc atcgtaatag atgcaacata 26401 aaatttgata tttattttgc cgtgctaagc ggggaggtag cggtgccctg tacctgcaat 26461 ccgctctagc agggccgaat cccttctcga ggttcgttta ctttaaggcc tgccttaagt 26521 aagtggtgtt gacgtttggg tcctgcgcaa tgggaattca tgaaccatgt caggtccgga 26581 aggaagcagc attaagtgaa acctctcatg tgccgcaggg ttgcctgggc cgagctaact 26641 gcttaagtaa cgcttagggt agcgaatcga cagaaggtgc acggtaaatc aatcatcaaa 26701 ttttcagact cacctaatat taggtgagtt ttttgttatg taaaaagagc ttttggaatc 26761 gaaacaaggt tcatgtataa tgggaatgat gaataacgga ggagggcaaa cccgtgagtt 26821 accaagcttt atatcgagta ttcaggcctc agcgctttga agatgtggtc ggacaagaac 26881 acattacaaa aacgctgcaa aatgcccttt tgcaaaaaaa gttttctcac gcctatctgt 26941 tttccgggcc tagaggaacc ggaaaaacca gtgcagccaa aatatttgct aaggctgtca 27001 actgtgaaca tgctcctgtt gatgagccat gcaacgaatg tgcggcctgt aaagggataa 27061 caaacgggtc aatatccgat gtcatagaaa ttgacgccgc ttctaataac ggtgttgatg 27121 agattcgtga cattcgcgat aaagtgaagt ttgccccatc ggccgtcaca tataaggtat 27181 atatcataga tgaggtgcat atgctttcta tcggcgcttt taatgcatta ctaaaaacat 27241 tagaagagcc gcctgagcat tgtattttca tattagcaac aactgaaccg cacaaaattc 27301 ctttaaccat tatctctaga tgtcagcgtt ttgactttaa acgaattacc tcccaagcga 27361 ttgtaggccg catgaataaa attgttgatg ctgaacagct gcaagtggag gaaggatcgc 27421 tggaaatcat cgcgagtgct gcagacggag ggatgaggga tgccctgagc cttcttgatc 27481 aggccatatc attcagcggc gatatcctga aagtcgaaga tgcgctttta attacgggtg 27541 ctgtttctca attatatatc gggaagcttg caaaatccct gcatgataaa aacgtttctg 27601 acgcactgga aacattaaat gaattgcttc agcaaggaaa agatccagct aagctgatag 27661 aagatatgat tttctatttc agggacatgc tgctgtacaa aacagcccct ggcttagagg 27721 gagtgcttga gaaagtaaaa gtcgatgaaa cgttccggga actaagtgaa caaattccgg 27781 ctcaggccct atatgaaatg attgatattc tgaacaagag ccatcaggaa atgaaatgga 27841 caaatcatcc gcgtatcttt ttcgaagtgg ccgttgtgaa gatttgccaa acctcacatc 27901 aatctgctgc tgatctcccg gaagtggata tgctgatgaa aaaaatccag cagctcgaac 27961 aggaagtaga gcggctcaaa acaacgggca taaaagcagc tgcggaaagc ccgaaaaaag 28021 aagcgccgcg tgtgccaaag ggcgggaaat ccaattacaa agcgccagta ggcagaattc 28081 atgagatttt gaaggaagcc acaagaccgg atcttgatct gctcagaaac agttggggca 28141 agcttcttgc tcatctcaaa cagcaaaaca aagtatcaca tgccgctttg ctgaatgaca 28201 gtgaacctgt ggctgccgga tcggcggcat ttgttctgaa attcaaatat gaaattcatt 28261 gtaaaatggt cgctgaggat aacaacggag tccggactaa tcttgagcag attttagaat 28321 cgatgctcgg aaaaagaatg gatttgattg gcgttccaga agcacaatgg ggtaaaataa 28381 gagaagaatt tttagaagat catcagcagg aaaatgaagg atcaaatgaa ccggctgaag 28441 aagacccgct tattgccgaa gcgaaaaagc ttgttggagc ggatttaatt gaaataaaag 28501 actaacaaaa tgaaagagag tgaatgctat gcgtggcgga atgggtaata tgcaaaaaat 28561 gatgaaacaa atgcaaaaaa tgcaaaagga catggcgaag gctcaagaag agcttgcaga 28621 aaaggttgtt gaaggaactg caggcggcgg tatggtaaca gtaaaagcaa acggccaaaa 28681 agaaatcctg gatgttatca tcaaagaaga agtcgttgat cctgaagata ttgatatgct 28741 tcaagattta gtgcttgctg caacgaatga agctttgaaa aaagttgacg aaatcacaaa 28801 cgaaacaatg ggtcaattta caaagggaat gaacatgcca ggtttattct agggggataa 28861 aagaacatgc aatatcctga accaatatca aagctgattg acagctttat gaaattgcca 28921 gggatcggac cgaaaacagc ggttcgtctg gctttttttg ttctaggtat gaaagaagat 28981 gtagtattag attttgcgaa agcattagta aatgcgaaac gcaacctgac atattgttca 29041 gtttgcgggc atattacaga tcaggaccct tgctatatat gtgaagatac gcgcagggat 29101 aagtctgtta tctgtgttgt gcaagaccct aaagacgtta tcgctatgga gaaaatgaag 29161 gaatacaacg gacagtatca cgttcttcac ggcgctattt ctccaatgga cggcatcgga 29221 ccggaggata ttaaaatacc agaattgtta aaacgattac aggatgatca agtgacagaa 29281 gtgatcctcg cgacaaaccc taatatagaa ggggaagcaa cagcgatgta tatatcaagg 29341 ctcctcaagc cgtctggtat taagctctcc cgtattgccc acggactgcc cgtcggcggt 29401 gatttggaat atgctgatga ggtcactctt tctaaagcac ttgaaggaag acgtgaattg 29461 taaggaggaa aaagcgatcc atgggttttc ttcgcaagaa aacattaaga agagagtttg 29521 atgaaaaact aaccgagcag ctttttaagc aaaaggaaga gtggaacagg caaaaaaagc 29581 tggttgaaaa aagcttagaa ccgtctgctg aagtgttata cgaactgaaa gtagctgaag 29641 cgaagtattt tttttactta agggaagcga agcagcgaaa tttaaaaatc agccggtgga 29701 agtaagtggt ctaaactcct ggatcttctc ataagcttgt actagaacaa gcgaaggaga 29761 tgagaagatt catggagcct atttttatta ttgggattat tttaggactg gttattcttc 29821 tttttttatc aggttcagca gcgaagcctt taaagtggat tggcatcaca gctgttaaat 29881 ttgtggcagg tgctttgctg ctggtttgtg taaatatgtt tggcggcagt cttggcattc 29941 atgtgccgat taatctggtt acaacagcta tcagcggaat tttaggaata cccggaatag 30001 ctgcgttagt cgtcattaag caatttatca tttaattgat attatgtatt gacttagaca 30061 actgaaggtg ttattctaat atacgtcgct gatgacgaac agcttttttg aaaagaaaat 30121 gctaaaaagt tgttgacagt agcggcggta aatgttatga taataaagtc gcttaaacga 30181 gcggtaaaca aagttctttg aaaactaaac aagacaaaac gtacctgtta attcattttt 30241 ataaatcgca cagcaatgtg cgtagtcagt caaactactt tatcggagag tttgatcctg 30301 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 30361 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 30421 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 30481 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 30541 tgaggtaacg gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca 30601 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 30661 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 30721 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 30781 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 30841 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 30901 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 30961 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 31021 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 31081 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 31141 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 31201 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 31261 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 31321 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 31381 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 31441 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 31501 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 31561 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 31621 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 31681 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 31741 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 31801 tcggaaggtg cggctggatc acctcctttc taaggatatt ttacggaata taagaccttg 31861 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggaacttt gttccttgaa 31921 taagttaaga tgggcctgta gctcagctgg ttagagcgca cgcctgataa gcgtgaggtc 31981 ggtggttcga gtccactcag gcccaccatc ttatataacg gggccttagc tcagctggga 32041 gagcgcctgc tttgcacgca ggaggtcagc ggttcgatcc cgctaggctc caccaacgtg 32101 ttctttgaaa actagataac agtagacatc acattcaatt agtaacacaa gatatcacat 32161 agtgattctt tttaacggtt aagttagaaa gggcgcacgg tggatgcctt ggcactagga 32221 gccgatgaag gacgggacga acaccgatat gcttcgggga gctgtaagca agctttgatc 32281 cggagatttc cgaatgggga aacccaccac tcgtaatgga gtggtatcca tatctgaatt 32341 cataggatat gagaaggcag acccggggaa ctgaaacatc taagtacccg gaggaagaga 32401 aagcaaatgc gattccctga gtagcggcga gcgaaacggg attagcccaa accaagaggc 32461 ttgcctcttg gggttgtagg acactctgta cggagttaca aaggaacgag gtagatgaag 32521 aggtctggaa aggcccgcca taggaggtaa cagccctgta gtcaaaactt cgttctctcc 32581 tgagtggatc ctgagtacgg cggaacacgt gaaattccgt cggaatccgg gaggaccatc 32641 tcccaaggct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga 32701 aaagcacccc ggaaggggag tgaaagagat cctgaaaccg tgtgcctaca agtagtcaga 32761 gcccgttaac gggtgatggc gtgccttttg tagaatgaac cggcgagtta cgatcccgtg 32821 caaggttaag cagaagatgc ggagccgcag cgaaagcgag tctgaatagg gcgcatgagt 32881 acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc cagggtgaag ttcaggtaac 32941 actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg gggatgaggt gtgggtaggg 33001 gtgaaatgcc aatcgaacct ggagatagct ggttctctcc gaaatagctt tagggctagc 33061 ctcaaggtaa gagtcttgga ggtagagcac tgattggact aggggcccct accgggttac 33121 cgaattcagt caaactccga atgccaatga cttatccttg ggagtcagac tgcgagtgat 33181 aagatccgta gtcgaaaggg aaacagccca gaccgccagc taaggtccca aagtatacgt 33241 taagtggaaa aggatgtgga gttgcttaga caaccaggat gttggcttag aagcagccac 33301 catttaaaga gtgcgtaata gctcactggt cgagtgactc tgcgccgaaa atgtaccggg 33361 gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca gtggtaggag agcgttctaa 33421 gggctgtgaa gccagaccgg aaggactggt ggagcgctta gaagtgagaa tgccggtatg 33481 agtagcgaaa gaggggtgag aatcccctcc accgaatgcc taaggtttcc tgaggaaggc 33541 tcgtccgctc agggttagtc gggacctaag ccgaggccga aaggcgtagg cgatggacaa 33601 caggttgata ttcctgtacc acctcctcac catttgagca atggggggac gcaggaggat 33661 agggtaagcg cggtattgga tatccgcgtc caagcagtta ggctgggaaa taggcaaatc 33721 cgtttcccat aaggctgagc tgtgatggcg agcgaaatat agtagcgaag ttcctgattc 33781 cacactgcca agaaaagcct ctagcgaggt gagaggtgcc cgtaccgcaa accgacacag 33841 gtaggcgagg agagaatcct aaggtgatcg agagaactct cgttaaggaa ctcggcaaaa 33901 tgaccccgta acttcgggag aaggggtgct ctgttagggt gcaagcccga gagagccgca 33961 gtgaataggc ccaggcgact gtttagcaaa aacacaggtc tctgcgaagc cgtaaggcga 34021 agtatagggg ctgacgcctg cccggtgctg gaaggttaag aggagcgctt agcgtaagcg 34081 aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact ataacggtcc taaggtagcg 34141 aaattccttg tcgggtaagt tccgacccgc acgaaaggcg caacgatctg ggcactgtct 34201 caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg caggttaccc gcgacaggac 34261 ggaaagaccc cgtggagctt tactgcagcc tgatattgaa tgttggtaca gcttgtacag 34321 gataggtagg agccttggaa accggagcgc cagcttcggt ggaggcatcg gtgggatact 34381 accctggctg tattgacctt ctaacccgcc gcccttatcg ggcggggaga cagtgtcagg 34441 tgggcagttt gactggggcg gtcgcctcct aaaaggtaac ggaggcgccc aaaggttccc 34501 tcagaatggt tggaaatcat tcgcagagtg taaaggcaca agggagcttg actgcgagac 34561 ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggttccg catggaaggg 34621 ccatcgctca acggataaaa gctaccccgg ggataacagg cttatctccc ccaagagtcc 34681 acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg gctgtagtca 34741 gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt cagaacgtcg 34801 tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat ttgagaggag ctgtccttag 34861 tacgagagga ccgggatgga cgcaccgctg gtgtaccagt tgttctgcca agggcatcgc 34921 tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc taagcatgaa gcccccctca 34981 agatgagatt tcccattccg caaggaagta agatccctga aagatgatca ggttgatagg 35041 tctgaggtgg aagtgtggcg acacatggag ctgacagata ctaatcgatc gaggacttaa 35101 ccacattttg aatgatgtca cacctgttat ctagttttga gagaacacct ctctaaaggc 35161 ggaaggtaag gaaactccgc taagggctct cacatcctgt gagaaacgcc cagtaccttc 35221 atcctgaagg catttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 35281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 35341 acgccgccaa gcaagcttaa acccagctta atgagctggg ttttttgttt actcaagatc 35401 gagaaaatca aacaaataca aacaccgagg gcttatatag cccatatact gatttaaagt 35461 ttcaaaaagg tctaaatagt gtatacaata tccgttttaa ggggaggcta actgtacgga 35521 ggtggagaag atggacgaaa cagttaaact taatcataca tgtgtgattt gtgatcaaga 35581 gaagaataga ggcattcatc tttatacgaa attcatatgc ttagattgtg agagaaaagt 35641 aatttctaca tcaacttctg atcctgacta tgcgttttac gtaaaaaaac taaagagcat 35701 tcatacaccg ccattatatt catagacctg aaaaggtctt tttttgtact cttaataata 35761 aaaagaagat gaaacttgtt taaggattga acgtagtaga taataatatt aaaactgagt 35821 atagacacag gagtcgatta tctcatgcag agattttttc actttttggt gtggagttta 35881 actagcagtg cgacttttgt tttcattgga atattgagct tttttggttt aaaccagtcg 35941 atttttttat ctattgttta tgggcttgct tctggagcag ccgtatatat agctggcatc 36001 tggaatgcaa gacggttatt tcttaaaaag catgaattga caggaagaga gtatgcttac 36061 attaagaaaa acttagagga agcaaggcag aaaatggtcc gtcttaggaa agccttgttt 36121 caggctaaaa gcattcaaat gtttaagcaa aatgcagaaa tgctaaggat tgtgagaagg 36181 atttatctcc tcaccaaaaa agagccaaag cggttttatc aggcagaacg atttttttat 36241 caaactctcg attcggttgt tgaattgaca gagaagtatg cttttctatc atctcaccca 36301 aaaaaaagca aagaactgtc gatgtcgtta agtgagacac gcatcactct tactgaattg 36361 accaagcgtt tagaggaaga tttaactcaa gcaatgggtg atgaaattga cgagttgcag 36421 tttgaattag acgcagcaaa acattcatta aagaaataag ggaagagggt aagagcgatg 36481 aaccgagacc aaagcgacct tcatatagat gaattattgg cagatccttt tggtggtaac 36541 atagagatac caggttcgga ggctgtaaaa gcagagaaag agcaagtacg gcttgttgat 36601 gttcttcctg aggaaaacaa ggaaaaagca attcagcttg ctggacagat tgatcataaa 36661 aatatgcaaa gcattgtctt atacggttca caagctcaat ctaaactgct gaacttttct 36721 catgatatga ttaatcatgt tcaaaagaag gatgtcgggg agattggcga aatacttgga 36781 gagctgatga aaaagctgga gcaagtaaat cctgatgatc tccaatctaa gaaaaagggt 36841 tttttggcac gcatgtttgg aagagtatca agttctcttc aagaggtgct gtctaaatac 36901 caaaagacca gtgtgcagat agacagaatc agcttgaagc tggagcactc taaaaatgct 36961 ttaatcagtg acaacaagct gttagagcag ttatatgaaa aaaataaaga atatttcgca 37021 gcgctgaatg tttatattgc tgcaggagaa ctgaagctgg aggaattaaa aacaaaaacg 37081 attcctgaac tgaagcaaca ggctgaatcg agtgatcata accaaatggc cgttcaagag 37141 gtgaatgatt taattcaatt tgctgaccgg ttagataaaa gggtgcatga tttgctgctg 37201 agcaggcaaa ttacaatcca aagtgcaccg caaatcaggc tgattcaaaa tacaaaccaa 37261 gcgttagctg aaaagattca gtcatccatt gtgacagcga ttccgttatg gaaaaatcaa 37321 gttgccattg cactgacgct tttaaggcag cgcaatgcag tggatgcaca gcagaaagta 37381 tctgatacaa ccaatgagct tttgctgaaa aatgcggagc ttttaaaaac caatacaatt 37441 gaaactgcac gggcaaatga aagaggcctt gttgatatag ataccttgaa gaaggtgcag 37501 gaaagcttaa taagcacgct tgaagaaaca ctgactatac aagaagaagg acgaatcaaa 37561 cgccgtcagg cagaagaaga gctcatgatg atggaaggcg acctgaagca aaagctgatt 37621 acaataaagg aaagatgatt accagtaagt ctggctttaa gttctgtcag aggcacgata 37681 taataaggtg taagaagaca cattcaaagg attgttttca tgaacacacc tttatataaa 37741 gcattaattc aacatgcgag aagaaattct cattcatttc atgttccggg acatcacaat 37801 ggagatgtct tttttgatga cgctaagtca atattcgatc cgcttctcac cattgatgta 37861 actgaactgg caggactgga tgatctccat catccttctg gggtgattaa ggaagctcag 37921 gagcttgcca gtcaattata tggatcggcg gaaagttttt ttctggtaaa tggtacgact 37981 gtcggaaact tagcgatgat tttatctgtt tgtgaacctg gtgatacaat tctggttcaa 38041 agaaactgtc ataaatctgt atttcatgct gttgatttgt ccggtgctga gccggtttat 38101 cttgcacctg acgttgattc agcgatgcat gtgcctacgc atgttccgct tggaacaatt 38161 aaagaggccc tggaagcata tccagatgcg aaaggcttgg tactgaccaa tccgacatat 38221 tacggacata gtgctgattt gactgagatc attactgaag cccatcatta cgggattcct 38281 gttttggtcg atgaagcgca tggcgcacat tttattttag gtgagccttt tccggtctca 38341 gctttaaaaa tgggggcaga tattgttgtt cagtcggccc acaaaacgtt gccagccatg 38401 acgatgggtt cttatttgca tctcaacagc agctgcagga ttaacaggga tcgggtggca 38461 gagtatttaa accgattaca aagcagcagc ccgtcttatc cgattatggc ttcgttagat 38521 attgcccgcg cttatgtaca gcatattata gaagaacaaa agctttctga cattctgcag 38581 cggatagaaa cacttaaaca aacgtttgat tcacttacaa atgcagaagc tgttaaccct 38641 gctaatccac tgatcatcac ggatccgcta aagctcacaa ttcgttcaaa acgcgggcat 38701 tctggctata cgctgcaaag cattttagag cgtgccaaca tattcactga gcttgctgat 38761 gaaaatcaag ttctgctcgt tctcccattg ggaggaaaac ggagaataaa cgctgaaatc 38821 attagaagca tcgatgaaga gattgagaaa acgcctccgg atcagacgtt tgtttctgca 38881 gaatggggtg tgcagcctgt tactgtcttg ccttatccaa aaaaggtctt acattcgttt 38941 aagaaagaat atgtgagctt tgaggaagca gctggccggc ttaatgcaga agatatcatc 39001 ccttatcctc cgggtatccc gatgattatg gcgggagaaa gaataacaaa agaaagtgtg 39061 caaaagctca gccgcttgat cagcatgaaa acgcatgttc aagggaatat gaaaatcaaa 39121 gagaaacaac tacttgttta tatagaagag gagaaatcat gagcggttta tttattacat 39181 tcgaaggtcc tgaaggtgca gggaaaacga ctgttctgca ggagatcaaa aacatactga 39241 cagcagaagg ccttcaggtt atggcaactc gagagccagg cggaatagat attgcagaac 39301 aaattagaga ggttattctg aatgagaaca atatattaat ggacccaaaa acagaagctc 39361 tcttatatgc ggctgcaaga cgccagcatt tagttgaaaa agtaaaacct gctttagaac 39421 aggggtttat cgttctttgc gacagattca tagacagttc tcttgcgtat caaggatatg 39481 caagagggct tggaattgat gaggttctgt ccattaatga atttgccatt ggagatatga 39541 tgccccatgt aacggtttat ttttcaattg atccggaaga aggactgaag cgtatttacg 39601 caaacggctc acgggagaaa aacaggctcg atttagaaaa actggacttt catacaaaag 39661 tacaagaagg ttatcaagag ctgatgaagc gatttccgga aagatttcat tcagttgatg 39721 ccgggcaatc caaagacctc gtcgttcagg atgttctaaa ggtgatcgat gaagcgttga 39781 aaaaaattca attgtgacct gtttcccaat agttgatata ataatgtaaa cgagatcacg 39841 ttgtttccaa tctaaaggag gccttcacag atgaaattga tagtggcagt tgtacaagat 39901 caggacagca acagactttt gaaaacctta acggatcaca acttcagagt cacaaagctt 39961 gcaacgacag gaggatttct taaatcaggc aatacaacgt ttatgatcgg tgtcgaggat 40021 atacgcgtca ataaagcgtt gagtctcatt aaagaaaacg ggcagaaacg tgatcagatg 40081 attgcccctg tatctccaat gggtggaaat gctgattcct atgtccctta tccagtcgaa 40141 gttgaagttg gcggagcgac agtatttgtc cttccagtcg atgaatttca tcaattttaa 40201 ggatctgaaa ctgtgaaaat taataaagat atacgtacat ttatagataa taagcagatt 40261 ccctctgtga aaacatctga gatcacagca tcgtttaaaa catcaatgga aaaccaaagc 40321 agcaaaatga agcttgatca gcttaccagg ctgttatctg atatagaagc atttggaaaa 40381 aggctaacga aatctcggaa ttttaaagac ttagcgagat ttaaaggact tgtgaaacgt 40441 tttgtcaaag aagctgtgga cagcggtctt tcacatgaaa catcgaaaag ctttgacctt 40501 tacgggaaca gcagaacgct gggacttgtg aaagaaatag atgacaaatt gatacagctt 40561 acggaagaga tgatggatca ggaaaaaccg gcaattgatt tgctggagcg tattggcgaa 40621 ataaaaggtt tattaattaa cctttacaca tagagagtga tacaatggca atatcctgga 40681 aggaaatgaa cgagcttcag cccagagtga tgaagctttt atataatagt attgagaagg 40741 acagactatc acacgcttat ttgtttgagg ggaaaaaagg aacaggcaag cttgatgccg 40801 cgctgcttct tgcaaaaagc ttcttttgtc tggagggtgg cgcggagcct tgtgagagct 40861 gccgaaactg taaacggata gagtcaggga accatcctga tctccatctt gttcagcctg 40921 atggcttatc aatcaaaaag gcgcaaattc aagcgctcca agaagagttt tctaagacag 40981 gacttgaatc gcataaaaag ctgtatatta tttcgcacgc agatcaaatg acagcaaatg 41041 cggcgaacag cctgctgaaa tttttagaag aaccgaacaa agacacaatg gccgtcctca 41101 tcactgagca gccccaaagg ttattggata ccatcatttc aagatgccaa acccttcctt 41161 ttcagccttt gcagccgaaa gcaattgaag acagactgat cgaacaggac gtctcgcctc 41221 atatggcaag gcttctggcc aacatgacta ataatgtagc agaagcagtc gaattaagtc 41281 gaaatgatga gtttgcagag tctagagcga aagtgataaa attgtatgaa gtcctacacc 41341 agcggaaagg acatgctttt ttctttattc aagatcaatg gatgcccttt ttcaaagaaa 41401 aaacccatca agaaatgggt cttgatatgc tcttattgat atatcgtgat gtgttgtcca 41461 tccaaatagg aaatgaagat aaattgattt atcaagactt attccaatca ataaaacagc 41521 atgcgctaca atcaacacaa caaagcgtta cgaatcagat acttgctgtt ttagaagcaa 41581 agaaacggct tcattccaat gtgaatgtac aaggattaat ggagcacttg gtgttaatgt 41641 tgcaggaggg ataagcttgt acaatgtaat tggtgtccgc tttaagaaag cgggtaaaat 41701 atattatttt gatccgaatg gatttcatat agaacatgac agctgcgtaa ttgtagaaac 41761 tgtcagaggc gttgagtacg gccaggtcgt aattgcaaat aaacaggtgg atgagcatga 41821 tgtggtgctt ccccttcgaa aagtgatacg tgtggcagac gatcgcgatc ttctcattgt 41881 agaagaaaat aaacaggaag cactatcagc atttgatatc tgccaaaaga aagtgattga 41941 gcatggcttg gatatgaagc tggtcgatgt tgaattcacg tttgatcgca ataaagtcat 42001 tttttacttc actgctgacg gccgagtcga ctttagagag cttgtaaagg atttggcttc 42061 tatctttaag acaagaattg agctgcgcca aatcggagtg agggatgagg caaaaatgct 42121 cggaggaatc ggtccttgcg gaagaatgct ttgctgttca acgtttcttg gagattttga 42181 acccgtttcc attaaaatgg ccaaggatca gaacttgtct ttaaatccta cgaagatttc 42241 gggtctttgc ggacgattga tgtgctgtct aaaatatgag aacgatgagt atgagacggc 42301 aaaagaacag cttccggata taggagaaat gattacgaca gcaaacggtc ccgcgaaggt 42361 cgtcggacta aatattctgg aacgggtgct tcaggtggaa ctgataaacc gtgaaaaagt 42421 gatagaatat acttgggaag agctcttgga agagggcgtc gtatccgcac aaaccacaga 42481 ttaacgaggt gtggaacctt ggataaaaaa gagttatttg atacagtcat taacttagaa 42541 gaacaaattg gctcactgta ccggcagctg ggggatttga agcagcatat cggtgagatg 42601 attgaggaaa atcatcattt acagcttgaa aacaagcatt tgcgcaaacg gctggacgat 42661 acgacgcagc agattgaaaa gttcaaagct gataaaaaag aatcaaaaac acagaagaca 42721 gagcaaactg atatagggga aggatatgat aatctggcac gtctgtatca agaaggattt 42781 catatctgca atgtccacta tggaagtgtt cgaaaagagg attgtctttt ctgtctgtca 42841 ttcttaaata aaaaataggg aaaaggcttc cgcataagac gggagccttt ttcaaaggta 42901 ctgaaaggat aagaagatgg tttcattaca tgatgatgaa agattagatt atttgctggc 42961 agaggacatg aaaatcatac aaagcccaac agtgtttgct ttttcgttgg acgctgtgct 43021 tctgtccaaa tttgcgtacg ttccgattca aaaagggaaa attgttgatt tatgcaccgg 43081 caatggtatt gtgccgctgc tgctcagtac aagatcaaaa gcagacattc tgggagtcga 43141 aattcaagaa agactgcatg atatggctgt tcgcagcgtg gagtataata agttggacga 43201 tcagatccag atcatacatg atgacctgaa aaacatgccg gagaaacttg gacataatcg 43261 atatgatgtt gtcacctgca atccgccgta ttttaaaacg ccgaaacaaa ctgaacaaaa 43321 catgaacgag catctccgaa tcgcaagaca tgaaatccac tgcacgctgg aggatgtcat 43381 ttcagtcagc agcaagctgc tcaagcaagg gggaaaagca gctcttgttc accggccggg 43441 aaggcttctg gagatttttg aactgatgaa ggcttatcaa atcgagccga aacgtgtaca 43501 atttgtctat ccgaagcaag ggaaagaagc caataccatt ttggttgaag gtatcaaagg 43561 cgggcgcccg gatttgaaaa ttcttcctcc cttattcgta tatgatgaac aaaatgaata 43621 tacaaaagaa atcaggacca ttttatatgg agacaaataa ccatttcttc tacgtcgtga 43681 aatgtaagga caatagctgg tatgccgggt ataccaacga tctgcataaa cgagtgaaaa 43741 cgcacaatga tggaaagggc gcaaagtaca caaaagtaag acgtccggtt gaattaattt 43801 ttgccgagag cttttcaaca aagcgggaag ctatgcaggc ggaatattat ttcaaaaaac 43861 taactcggaa gaaaaaagag ctttatatag aagaaaagcg gaacagcaag gaggctgtat 43921 atgttaaggc gccaaatgag ctttaatgga aagtcggaca tggggattct ttacttggtc 43981 ccaaccccaa tcggaaattt agaggatatg acattccggg cgatcgacac gctgaaatca 44041 gtggatgcga ttgctgcgga agatacgagg caaacgaaaa agctttgtca tgtatatgaa 44101 attgaaacac cgctcgtcag ctatcacgaa cacaataaag aaagcagtgg gcacaaaatt 44161 attgaatggc tgaaatcggg aaaaaacatt gctcttgtca gtgatgccgg tctgccgacg 44221 atttctgatc ccggagcgga aattgtaaag gattttacgg atataggcgg ttatgttgtt 44281 ccgttgccgg gagcaaatgc tgcattaaca gctcttattg cttcaggtat tgtaccgcag 44341 ccttttttct tttacggttt tctcaacaga cagaaaaaag aaaagaagaa ggagcttgaa 44401 gcccttaaaa aacggcagga aacgatcatt ttttatgaag cgccccacag attgaaggaa 44461 accttgtcag cgatggcaga gatattagga gatcgggaaa ttgctgtaac acgtgaactc 44521 actaagaaat atgaagagtt tatccgagga accatatctg aggtcattgg atgggcaaac 44581 gaggatcaga tacgcggcga gttttgtctt gtcgtagaag gaagtaataa tgaagaggta 44641 gatgaggaag aacaatggtg ggaaaccctc actgcgaaag aacatgtcga gcattacatt 44701 tcgaaaggcg ctacgtctaa agaagctatt aaaaaagcag cagtcgatcg caatgtacca 44761 aagcgtgaag tgtacgatgc ttaccatatt aagcaataaa aaaacgttct tgtgtcataa 44821 caagaacgtt ttttgtacaa gaaatgatta tttaaggttt tgaagctggt tttggatttc 44881 gctgatgatt tgctcagcgc cttctttact aagaaccaat ttaccgcctg caagtttaag 44941 gttatcatca gaaacttcac cagttacttg gcaagtcatg tttggtttat attttttaag 45001 gatgattttt tcatcatcaa catagatttc aagagcatct ttttctgcga ttccaagagt 45061 acgacgcagt tcgataggaa taactacacg tcctaattca tcaactttac gtacaatacc 45121 agtagatttc ataaacattc tcctcccaag agatacttat ttgtttaaat tatatttttc 45181 ttcgtcatta ttcgacaaaa tccttacctt catagcataa caaggtttcc aataatcgtc 45241 aatcattttg tttactattg attgtaagaa ttagttctta tagtcagtaa tgtcttggaa 45301 actaccgaaa taacagcatt ttataaatat ttaataaagc tattatccta ctaaaaatcc 45361 ttttaaatca agactttcga accaaagttt tttatttcat ttgattatat acgacaaaat 45421 tcgacacgaa cagacttttt ttattttcat taaagatttt taattttaat tattcttttt 45481 cagggcgtat gtatatattc ttgatcttaa aggctaagat ggtatcatag ataaaggata 45541 aatataaata atattcatat atgatttgca cttatcgccg ctctcgtcct ttgggcggga 45601 gctttttgac attctgatta ggaggtttca agatgccgca agaaaacaat acattttaca 45661 ttacaacacc gatttattat ccgagcggaa aattacatat cggccatgca tatacgacag 45721 tcgcaggaga tgcaatggca cgttacaaaa gattaaaagg gttcgatgtt cgctatttaa 45781 cgggaacgga cgagcatgga caaaagatcc agcaaaaagc tgaacaggaa aacattacac 45841 ctcaggagta tgtggatcgc gcagcggcag atattcaaaa actgtggaag cagcttgaaa 45901 tctcaaacga cgactttatc cgcacgacag aaaaacggca taaagttgtc attgaaaaag 45961 tgtttcaaaa gcttcttgat aacggggaca tctatcttga tgagtatgaa ggctggtaca 46021 gcatccctga tgaaacgttc tacacggaaa ctcagctcgt tgatattgag cggaatgaaa 46081 agggagaggt catcggcgga aaaagccctg acagcggtca cccagttgaa ttgatcaaag 46141 aggaatctta tttcttccgc atggggaaat acgcggatcg tcttctgaaa tactatgaag 46201 aaaacccgac attcattcag ccagaatcac gcaaaaacga aatgattaat aactttatca 46261 aacctggact tgaggatttg gcagtatcac gtaccacttt tgattggggc gtgaaggtgc 46321 cggaaaatcc aaagcatgtt gtatatgttt ggattgacgc actatttaac tatttaacgg 46381 cactcggtta tgatacagaa aatgatgagc tttatcaaaa atattggcct gccgatgttc 46441 atttagtcgg taaggagatt gtacgattcc atactattta ctggccaatt atgctgatgg 46501 cgctggatct tccgctgcca aagcaagtat tcgcgcatgg ctggcttttg atgaaagacg 46561 gaaaaatgtc gaaatcaaaa ggaaacgttg tagatccggt tacattaatt gaacgctatg 46621 gtttagacga acttcgctat tacttgcttc gcgaagtgcc gttcggatca gacggtgttt 46681 tcacgccgga aggatttgtt gagcgaatca actatgattt agcgaatgat ttaggaaatc 46741 tattgaatcg tactgttgcg atgattaata agtattttga cggacaaatc ggttcttaca 46801 aaggtgctgt tacggaattt gaccatacgc tcacttctgt tgctgaagaa acagtgaaag 46861 cttatgagaa agcaatggaa aatatggagt tctcggtagc actttcgact ttatggcagc 46921 tcatcagccg cacaaacaaa tacattgatg agacagctcc atgggtgctt gcgaaagatc 46981 cggcaaaaga agaagaattg cgatcagtta tgtatcatct cgctgaatca ttgcgtattt 47041 cagcggtact gcttcagcca ttcttaacaa aaacacctga aaaaatgttc gagcagctgg 47101 gcattactga tgaatcttta aaagcttggg acagcattac agctttcggc cagctgaaag 47161 atacaaaagt acaaaaaggc gagccattgt tccctcgttt agaggcagaa gaagaaattg 47221 cttacatcaa agggaaaatg caaggttcag caccagcgaa agaagaaaca aaagaagaag 47281 agcctcaaga ggtcgatcgt ttacctgaaa ttacgattga tcaatttatg gatgtagagc 47341 ttcgcgtagc tgaggtcatt gaggcagagc cagtgaaaaa agcagaccgt ttattgaagc 47401 tgcagcttga tcttggtttt gaaaagcgcc aagtggtatc cggcattgcg aagcattata 47461 cgcctgaaga gcttgttgga aaaaaactcg tttgtgtaac aaatctaaaa ccggttaaac 47521 tcagaggaga gctttctcaa ggtatgatcc ttgcaggaga agcagacggc gttttaaagg 47581 tcgtatctat cgatcagtcg ttaccaaaag gcacaagaat taaataatga taaacaaaag 47641 gtgtttcacg tgtaacaatt cgtcgaacac cttttgtgtt tcgacaagaa aggagttttt 47701 cacttatgtt gtttgacact cacgcgcatt taaatgcaga acaatatgat actgatcttg 47761 aagaggttat tgaacgggca aaagctgaaa aagttgaacg aattgtcgta gttggttttg 47821 accgtccgac gattacccgt gcgatggaaa tgattgagga atatgatttt atttatgcag 47881 ccattggctg gcaccctgtt gacgctattg acatgacaga ggaagactta gcgtggatta 47941 aagagctttc tgctcatgag aaagtggtag cgatagggga aatgggactg gattatcatt 48001 gggataaatc acctaaagat attcaaaaag aggtgtttag aaatcaaatc gccttagcga 48061 aagaggtcaa tttgcctatt atcattcata accgtgatgc aacggaggat gtcgtgacca 48121 ttttgaaaga ggaaggcgca gaagctgtgg gcggaatcat gcactgcttt acaggaagtg 48181 cggaagtggc aagagaatgc atgaaaatga atttttattt atcatttggg ggaccggtga 48241 catttaaaaa tgcgaagaaa ccgaaggaag tagtgaagga aattcccaat gaccggctgc 48301 tgattgaaac ggactgcccg tttctcacac cgcacccttt ccgcgggaaa agaaatgagc 48361 caagctatgt gaaatatgtg gcagaacaaa tcgccgaatt aaaagaaatg acctttgaag 48421 agattgcttc catcacgact gaaaatgcga aaagactttt ccgtataaac tgacaaaaaa 48481 cgctagcggg ttttgtaaga gcttgtccct tacagcgttt ttctataaaa gttctacatg 48541 ctttcttctc ctcataggat aggtttgtcg acaagtcttt cttccgtttc tcagtgtatt 48601 tcaggataat gaagaggaca ctgagctttt gggagaaaga gaagggaggg ttgacagcct 48661 tttagatact ctatataatc tctccgagga gaaggaggcg tttttcatca cacaaaaaat 48721 gaaaaagctg ttttccgtaa agcttagcaa aagcaaagtc attctggttg ctgcttgttt 48781 gcttttggca ggaagcggga ctgcgtacgc ggctcatgag ctgacgaaac aatcagtctc 48841 agtttctatc aatggcaaaa agaaacatat acgcacacat gcaaatacag tcggtgatct 48901 tttggagacg cttgatataa agacaagaga cgaagacaag atcacacctg ctaaacagac 48961 aaagataaca gcagacatgg acgttgtgta tgaggctgca aaacctgtga agcttacaat 49021 aaacggggaa gaaaagacgt tatggtcaac agcaaaaacg gtcggtgcat tactggacga 49081 acaagatgtt gatgtgaaag aacaagatca aattgatccc gcaatagata cagatatttc 49141 gaaagacatg aagattaaca tagagcccgc atttcaggtt actgtgaatg atgcagggaa 49201 acaaaagaag atctggacga cttcgactac ggtcgctgac tttttaaaac agcaaaagat 49261 gaacataaaa gacgaagata aaatcaagcc tgcgttagat gcaaagctga cgaaaggaaa 49321 ggctgatatt acaattactc gtatcgaaaa ggtcaccgat gtagttgaag agaagattgc 49381 gttcgatgtg aaaaagcaag aagacgcttc tcttgaaaaa gggaaagaaa aggtcgtcca 49441 aaaaggaaaa gaaggcaagc taaaaaaaca tttcgaagtc gttaaagaaa acggtaaaga 49501 agtgtccaga gagcttgtaa aagaagaaac agctgaacaa agcaaagata aagtgattgc 49561 tgtcggcaca aagcaaagca gtccaaaatt tgaaacggtc agtgcttcag gtgattcaaa 49621 aacagttgtg tcccgcagca atgaatcaac aggcaaagtc atgactgtat catctacggc 49681 ttatacggca agctgcagcg gttgttcagg acatacagcg acaggcgtca atttaaaaaa 49741 taatccgaat gccaaagtca tcgctgtgga tccaaatgtc attccgctag gctccaaagt 49801 ccacgtggaa ggctatggat atgccattgc tgcagatacc ggttcagcga ttaaagggaa 49861 caagatagac gtctttttcc cagagaaatc atcggcgtac cgatggggaa ataaaacagt 49921 caaaattaaa atcttaaatt agtatatact tatgtattca gagggttttg cgccctctgt 49981 ttttttcgtt ataatagaca aagtgcattt tctgcttatt agacgctcga tataagaaaa 50041 agtttcatga atatacaaaa gtttttattt tgtcttggag gaaataatga aaattaaaga 50101 gatcattgtg gtcgaggggc gtgacgatac ggcccgcatc aaattggctg ttgatgcaga 50161 cacaattgaa acaaatggtt cagccatcga tgatcatgtg attgaccaaa tccgtttggc 50221 ccagaagacg agaggcgtca ttattttaac ggatccggac tttccgggag agaagattcg 50281 caaaaccatc tcagaggctg tacccggctg taagcatgca tttttgccaa aacatcttgc 50341 caaacctaaa aacaagcggg gaattggtgt ggagcatgca tcggttgaaa gcattagggc 50401 atgtttagaa aatgtgcatg aggagatgga agcgcagccg agtgacattt cagctgagga 50461 tttgattcat gccggactaa taggcgggcc tgcggccaaa tgccgccggg aacgactggg 50521 tgatctgttg aaaatcggct atacaaatgg caaacagctt caaaaacggc tgcaaatgtt 50581 tcaaattaaa aaaagtgatt ttatgagtgc gctcgatacc gttatgcggg aggaacagaa 50641 tgaataaaga tattgcgaca ccgattagaa cgaaagagat actgaagaaa tacggttttt 50701 cttttaaaaa gagcttagga cagaatttct taattgatac gaacatttta aacagaattg 50761 ttgatcacgc ggaagtgacg gagaaaacag gtgtcattga aatcggcccg ggaatcgggg 50821 ctttaaccga acagcttgcc aagcgggcga aaaaggtcgt ggcatttgag attgaccagc 50881 gattattgcc gattctgaag gatacactgt caccttacga aaatgtcact gtcattcatc 50941 aggacgtgtt aaaggctgat gtcaaatcag tcattgaaga acaatttcaa gattgtgatg 51001 agatcatggt agttgccaac cttccttatt acgtaacaac accgattatc atgaaactgc 51061 ttgaagaaca tcttccgctg aaagggattg tggttatgct gcaaaaagaa gtggctgagc 51121 gcatggcggc tgatccttca tctaaggaat acggctcgct ttcaatcgcg gtgcagtttt 51181 atacagaagc caaaacggtg atgatcgtcc cgaaaaccgt atttgttcct cagcctaatg 51241 tcgattccgc agtcattcgt ctgattctcc gagacggccc ggcagtggac gtggaaaacg 51301 aatccttttt ctttcagctc atcaaggcaa gctttgcaca gcgccgtaaa acgctgctca 51361 ataacttagt taacaatctg cctgaaggaa aagcacaaaa atcaacgatt gaacaagtgc 51421 tcgaagaaac aaatattgac ggtaagcgcc gaggtgaatc cctgtctatt gaggaattcg 51481 cagcgctgtc taacggattg tataaagccc ttttctaaaa gggctttttg ttttgcgcac 51541 cacatggact gccgctacat aggctagaga aggacctttc attcaatgat aagaaaaaac 51601 ttggactcag cgaaaaaagg cgctttctca aggctctttc tttcatgatg aggcttagtc 51661 tatgtgtgga gtgaggaacg tgcaatttca aataggggat atggtagcca gaaaatccta 51721 tcagatggat gttttgtttc gaattatagg aatagagcaa acaagcaaag gaaattcaat 51781 tgccattttg catggagatg aagtcaggct gattgctgat tcggattttt ctgatctggt 51841 ggcagtgaaa aaggatgagc agatgatgcg gaaaaagaaa gatgagagca gaatgaatga 51901 gtcgctcgaa ttgctccgcc aagattataa gctgctcaga gaaaagcagg agtactatgc 51961 gacaagccaa tatcagcatc aggagcatta tttccatatg ccgggcaaag tgcttcatct 52021 ggatggtgac gaagcatatt tgaaaaaatg cctgaatgtc tataaaaaaa ttggagtgcc 52081 ggtctatggc atccattgcc atgaaaagaa aatgtctgct tctattgaag tattgctcga 52141 caaatatcga cctgacatcc tggtgatcac agggcatgat gcgtactcga agcaaaaggg 52201 cggtattgat gatttgaatg cgtacagaca ttctaagcac tttgttgaaa cagttcaaac 52261 agcccgaaaa aagatccctc acttagatca gcttgttatt tttgcggggg cctgccaatc 52321 ccattttgaa tcactcatca gagcgggtgc gaattttgca agttcaccgt caagagtcaa 52381 tattcatgcg cttgatccgg tatatatcgt cgcgaagatc agctttacgc cgtttatgga 52441 acggattaat gtatgggaag tgctccgtaa tacgctgaca agagagaaag ggcttggagg 52501 tattgaaaca agaggagttc tgagaattgg tatgccttat aagtccaatt aacagttgaa 52561 aacctgcata ggagagctat gcgggttttt tattttacat aatgatacat aatttaccga 52621 aacttgcgga acataattga ggaatcatag aattttgtca aaataatttt attgacaacg 52681 tcttattaac gttgatataa tttaaatttt atttgacaaa aatgggctcg tgttgtacaa 52741 taaatgtagt gaggtggatg caatggcgaa gacgttgtcc gatattaaaa gatcgcttga 52801 tgggaattta ggtaaaaggc tgacgttaaa agcaaacggt ggccgccgaa aaacgattga 52861 gcgttcgggc attttagctg agacgtaccc ttctgttttt gtgatacaac tagatcaaga 52921 cgagaactcg tttgaaagag tttcatacag ttatgctgat attttgactg agactgttga 52981 gctgacattt aatgatgacg ccgcaagctc agtggcattt taacgggcag tgaacctttt 53041 gtttactgct ttttgttttg cccttttttg gtttccaata attttaacga aagttccatc 53101 tgatttaaca aaagataaaa cagtcacata ttatcgtgac gtgcacgaat ggctatcact 53161 tctaaaaaag gagttgtttc gtttgggcag acgtcgtgga gttatgtcag atgagtttaa 53221 atatgagctg gctaaagacc ttggttttta tgacacagta aaaaatggag gctggggtga 53281 aattcgggcc cgcgatgccg gtaacatggt gaagcgtgct attgaaatcg ccgaacagca 53341 aatggctcag aatcagaata accgataagg atgtgacccg ggggacgtgc tgttccctgg 53401 tttttttatt ttggatataa atacataatg ggctgaatat ggatatgttc atcctgtact 53461 tcaaatgtga tacaatgttc atacttatgt ttagatggag aagtaggtga aagctatgcg 53521 tattttagaa aaagcgccag ctaagatcaa tctgtcactt gacgtcaccc gaaaacgccc 53581 ggatggctat catgaagtcg aaatgatcat gacgacaatt gatttagctg atcgaattga 53641 attgacggag cttgcagagg atgaagtgag ggtttcctcc cacaaccgat ttgtgcctga 53701 tgaccaaaga aacttagctt atcaggctgc caagctgatc aaggacagat acaacgtgaa 53761 aaagggagtt tccatcatga ttacgaaggt aattccggtg gctgccggtc ttgccggcgg 53821 aagcagtgat gcggcggcga cactcagagg gctgaacaga ctgtggaatt taaatctgtc 53881 cgcggaaacg cttgctgagc ttggagcgga aattggctct gacgtttcat tttgtgtcta 53941 tggcggaact gcattagcaa cagggcgcgg cgagaaaatt aaacatatca gcacgcctcc 54001 gcactgctgg gtcattttag cgaagccgac aatcggtgtt tcaactgctg aagtgtacag 54061 agcgctgaaa ctggatggta tagagcatcc cgatgtacaa ggcatgatcg aggcgataga 54121 agaaaagagt tttcagaaga tgtgcagccg gttaggcaat gtgcttgaat ctgttacact 54181 cgatatgcat cctgaagttg cgatgatcaa aaaccagatg aaacgctttg gtgcagatgc 54241 cgtgttaatg agcgggagcg gcccgacagt gtttggactg gttcagtatg agtcgaaggt 54301 gcagagaatt tataacgggt taagaggctt ctgcgatcaa gtttatgcgg tgagaatgat 54361 cggcgaacag aacgctcttg attaaatccg tatgttaagt tatattgatc ttaaaatatt 54421 cggattttgg gggtgagttc atgaagtttc gtcgcagcgg cagattggtg gacttaacaa 54481 attatttgtt aacccatccg cacgagttaa taccgctaac ctttttctct gagcggtatg 54541 aatctgcaaa atcatcgatc agtgaagatt taacaattat taaacaaacc tttgaacagc 54601 aggggattgg tactttgctt actgttcccg gagctgccgg aggcgttaaa tatattccga 54661 aaatgaagca ggctgaagct gaagagtttg tgcagacact tggacagtcg ctggcaaatc 54721 ctgagcgtat ccttccgggc ggttatgtat atttaacgga tatcttagga aagccatctg 54781 tactctccaa ggtagggaag ctgtttgctt ccgtgtttgc agagcgcgaa attgatgttg 54841 tcatgaccgt tgccacgaaa ggcatccctc ttgcgtacgc agctgcaagc tatttgaatg 54901 tgcctgttgt gatcgttcgt aaagacaata aggtaacaga gggctccaca gtcagcatta 54961 attacgtttc aggctcctca aaccgcattc aaacaatgtc acttgcgaaa agaagcatga 55021 aaacgggttc aaacgtactc attattgatg actttatgaa agcaggcggc accattaatg 55081 gtatgattaa cctgttggat gagtttaacg caaatgtggc gggaatcggc gtcttagttg 55141 aagccgaagg agtagatgaa cgtcttgttg acgaatatat gtcacttctt actctttcaa 55201 ccatcaacat gaaagagaag tccattgaaa ttcagaatgg caattttctg cgttttttta 55261 aagacaatct tttaaagaat ggagagacag aatcatgaca aaagcagtcc acacaaaaca 55321 tgccccagcg gcaatcgggc cttattcaca agggattatc gtcaacaata tgttttacag 55381 ctcaggccaa atccctttga ctccttcagg cgaaatggtg aatggcgata ttaaggagca 55441 gactcatcaa gtattcagca atttaaaggc ggttctggaa gaagcgggtg cttcttttga 55501 aacagttgta aaagcaactg tatttatcgc ggatatggaa cagtttgcgg aagtaaacga 55561 agtgtacgga caatattttg acactcacaa accggcgaga tcttgtgttg aagtcgcgag 55621 actcccgaag gatgcgttag tcgagatcga agttattgca ctggtgaaat aataagaaaa 55681 gtgattctgg gagagccggg atcacttttt tatttacctt atgcccgaaa tgaaagcttt 55741 atgacctaat tgtgtaacta tatcctattt tttcaaaaaa tattttaaaa acgagcagga 55801 tttcagaaaa aatcgtggaa ttgatacact aatgctttta tatagggaaa aggtggtgaa 55861 ctactgtgga agttactgac gtaagattac gccgcgtgaa taccgatggt cgcatgagag 55921 cgattgcatc catcacgctg gatcacgaat ttgttgtaca tgatattcgt gtgattgatg 55981 gaaacaatgg tcttttcgtt gcgatgccga gtaaacgcac ccctgatgga gagttccgcg 56041 atattactca tcctattaat tcaagcacgc gaggaaagat tcaagatgcc gtgttaaatg 56101 agtatcatcg tctgggtgac actgaagcat tagaattcga agaagctgga gcttcttaaa 56161 aaataaccaa aaagcaagga ctgctgaaag ggctgacata agccttttgc cggcggtcct 56221 tttttaattc tgatttttca aacttagttg cactcaatag aaaattcttg cacttcatga 56281 agtctccttg aaatcagaag atatttagga tatatttttc tatggataaa agggatattg 56341 gaggccaata aatggataag cggtttgcag ttgttttagc ggctggacaa ggaacgagaa 56401 tgaaatcgaa gctttataaa gtccttcatc cagtttgcgg taagcctatg gtagagcacg 56461 tcgtggacga agccttaaaa ttatctttat caaagcttgt cacgattgtc ggacatggtg 56521 cggaagaagt gaaaaagcag cttggtgata aaagcgagta cgcgcttcaa gcaaaacagc 56581 ttggcactgc tcatgctgta aaacaggcac agccatttct tgctgacgaa aaaggcgtca 56641 caattgtcat ttgcggagat acgccgcttt tgacagcaga gacgatggaa cagatgctga 56701 aagaacatac acaaagagaa gcgaaagcta cgattttaac tgcggttgca gaagatccaa 56761 ctggatacgg ccgcattatt cgcagcgaaa acggagcggt tcaaaaaata gttgagcata 56821 aggacgcctc tgaagaagaa cgtcttgtaa ctgagatcaa caccggtacg tattgttttg 56881 acaatgaagc gctatttcgg gctattgatc aggtgtctaa tgataatgca caaggcgagt 56941 attatttgcc ggatgtcata gagattctta aaaatgaagg cgaaactgtt gccgcttacc 57001 agactggtaa tttccaagaa acgctcggag ttaatgatag agttgctctt tctcaggcag 57061 aacaatttat gaaagagcgc attaataaac ggcatatgca aaatggcgtg acgttgattg 57121 acccgatgaa tacgtatatt tctcctgacg ctgttatcgg aagcgatact gtgatttacc 57181 ctggaactgt gattaaaggt gaggtgcaaa tcggagaaga tacgattatt ggccctcata 57241 cggagattat gaatagtgcc attggcagcc gtacggttat taaacaatcg gtagtcaatc 57301 acagtaaagt ggggaatgat gtaaacatag gaccttttgc tcacatcaga cctgattctg 57361 tcatcgggaa tgaagtgaag atcgggaatt ttgtagaaat taaaaagact caattcggag 57421 accgaagcaa ggcatctcat ctaagctatg tcggcgatgc tgaggtaggc actgatgtaa 57481 acctgggctg cggttcaatt actgtcaatt atgatggaaa gaataagtat ttgacaaaaa 57541 ttgaagatgg cgcgtttatc ggctgcaatt ccaacttggt tgcccctgtc acagtcggag 57601 aaggcgctta tgtggcggca ggttcaactg ttacggaaga tgtacctgga aaagcacttg 57661 ctattgccag agcgagacaa gtaaataaag acgattatgt gaaaaatatt cataaaaaat 57721 aatcctaaat tcggaggttt atccatgtct aatcaatacg gagataagaa tttaaagatt 57781 ttttctttga attcgaatcc agagcttgca aaagaaatcg cagatatagt tggagttcaa 57841 ttagggaaat gttctgtcac aagatttagt gacggggaag tccaaattaa tatcgaagaa 57901 agtattcgcg gatgtgattg ttacatcatc cagtctacaa gtgaccccgt taacgagcat 57961 attatggaac tgctgattat ggtagatgcg ttaaaacgcg cttctgcaaa aacgattaac 58021 attgttattc cttattacgg ttatgcgcgt caagacagaa aagcaagatc ccgtgagcca 58081 atcacagcta aacttttcgc taacctgctt gaaacagccg gtgcgactcg tgtgattgca 58141 cttgacctgc atgcgccgca aattcaagga ttctttgata taccgattga ccacttaatg 58201 ggtgttccga ttttaggaga atattttgaa ggcaaaaatc ttgaagatat cgtcattgtt 58261 tcaccagacc atggcggtgt gacacgtgcc cgcaaactgg ctgaccgact aaaagcgcca 58321 attgcgatta tcgataaacg ccgtccgcgt ccaaacgtgg cggaagtcat gaatattgta 58381 ggtaacatcg aagggaagac tgctatcctc atcgatgaca ttattgatac tgcaggtacg 58441 attacacttg ctgctaatgc gctcgttgaa aacggagcga aagaagtata tgcatgctgt 58501 acacaccctg tactatcagg ccctgcggtt gaacggatta ataattcaac aattaaagag 58561 cttgttgtga caaacagcat caagcttcct gaagaaaaga aaattgaacg ctttaagcag 58621 ctttcagtcg gaccgcttct ggccgaagcg attattcgcg ttcatgagca gcaatcagtc 58681 agctatctgt tcagctaaac catttttcga ggtttaaatc cttatcgtta tgggtattgt 58741 ttgtaatagg acaactaaaa cgacaagagg atggtgctga atatggcaac tttaacggca 58801 aaagaaagaa cggactttac tcgttcgtct cttcggaata tccgtacttc aggacatgtt 58861 ccaggtatca tatatgggaa ggatacgggt aacaaacctg tgtcattaga cagtgtggag 58921 ctcatcaaaa cgctgaggga cgaaggcaaa aatgcagtca ttacgcttga ggtcagcgga 58981 gaaaaacact cagtcatggt aacagacctg cagacggacc cgctgaaaaa tgaaatcact 59041 catgctgatt ttcaagtagt taatatgagt gaggacattg aagtggaagt tccgattcat 59101 ctgaccggag aagccattgg agtgaaaaac ggaggcgtac tgcagcagcc gttatatgca 59161 cttactgtaa aggccaagcc aaaagccatt ccgcaaacga ttgaggctga tatttcaagc 59221 ctcgatgtaa atgaagtact gacgattgcg gatttgcctg ctggcggtga ctactccttt 59281 aatcatgaat cagatgaggt tgtggcttca atccttcctc cgcagcagca ggaagcagct 59341 gaggtcgatg aagaggaatc tgccgatgct cagcctgaag gtgaaaacga acaataatag 59401 cttaaggcgt aaccctcccg cggttacgtc ttttgtgcta gaatgagaag aattatagcc 59461 cgtttatgaa gacgggagtt atgtgactaa gggaggattc gccatgcttg tgattgccgg 59521 tctcggaaac ccggggaaga actatgaaaa tacacggcat aatgtcggat ttatggtgat 59581 agatcagctt gcaaaggaat ggaatataga gctgaatcaa aataaattta acggattata 59641 cggaaccgga tttgtttccg gcaaaaaggt tctacttgtt aaaccgctta catatatgaa 59701 tttatcagga gaatgtttgc ggcctttaat ggactactat gatgtcgata acgaagattt 59761 gacagtcatt tacgacgacc ttgaccttcc gactggcaag atccgtttaa gaacgaaagg 59821 aagcgccgga gggcacaatg gcatcaaatc actgatccag catcttggaa cgtccgagtt 59881 tgaccgtatc cgcatcggaa tcggccggcc tgtaaacggc atgaaggtcg ttgattatgt 59941 gttaggctcc tttaccaagg aggaggcacc tgagatcgaa gaagcggttg ataaatctgt 60001 gaaggcttgt gaggcttctt tgagtaaacc gtttttagaa gtcatgaacg aatttaacgc 60061 aaaggtataa aatgtaacaa caaagtccat actacaccaa aatgactttt tcatcaggag 60121 gacccttgta tggctttgca ttattattgt cgtcattgcg gagtgaaagt aggcagtctc 60181 gaatcttcaa tggtatcgac agactcactt ggatttcagc acttaacaaa tgaggaaaga 60241 aacgatatga tttcttataa agaaaatgga gatgtccatg ttttgacgat atgtgaagac 60301 tgccaagagg cgcttgaccg aaatccgcat taccacgaat atcacacatt tattcaataa 60361 aaagctttgg tgtagacact agaccaaagc gtttttctgt tctcgcagga aacagagagg 60421 aggggccata tggacaacat tcaaaccttt ataaaagaaa gcgatgactt taaatccatc 60481 atcaacggtt tacacgaggg cctgaaggaa cagctgctcg cgggtctgtc gggttccgcg 60541 cgttctgttt ttacttctgc tctggctaat gaaacgaata agcctatctt tctcatcacc 60601 cataacttat atcaagccca gaaagtaaca gatgatctga cttcacttct agaggatcgg 60661 tctgtccttt tgtaccccgt caatgaactc atttcatcag aaatcgcagt tgcaagccct 60721 gaattgcggg cgcagcgatt agatgtcatt aatagactaa cgaatggaga agcgccaatt 60781 gtcgttgctc cggtagctgc aatcagaaga atgctgccgc ctgttgaggt gtggaaaagc 60841 agccagatgc tcattcaagt aggccatgat attgaacctg accagcttgc ctcacggctg 60901 gtagaggtag ggtatgagcg gtctgatatg gtttctgcgc ccggggaatt cagtattcgc 60961 gggggaatca ttgacattta tccgctgact tcagagaatc cggtgagaat tgaacttttt 61021 gacaccgagg tggattcaat ccgcagcttt aattcagatg atcagcggtc aattgagacc 61081 cttacctcga tcaatatcgg tcccgcgaag gaattaatta tcagaccgga agaaaaagcg 61141 cgggcgatgg agaaaatcga tagtggtctt gccgcgagct tgaaaaaatt aaaggctgac 61201 aaacaaaaag aaatacttca tgcgaatatt tctcacgata aagaacgctt gtctgaaggc 61261 cagacagatc aggagctcgt gaagtatctc tcatatttct atgaaaagcc tgctagttta 61321 ctagattata cacctgataa tacacttctg attttggatg aagtcagtcg gattcatgag 61381 atggaagaac agcttcaaaa agaagaagcg gagtttataa caaatcttct tgaggaaggg 61441 aagattttgc atgacattcg tttgtcattc agcttccaaa aaatagtggc tgagcaaaaa 61501 cggcctctgc tgtactactc tttatttttg cggcatgtac accatacgag cccgcaaaat 61561 atcgtcaatg tgtcaggccg gcaaatgcag agtttccatg gccaaatgaa cgtgcttgcg 61621 ggcgaaatgg agcgttttaa aaaatcaaat ttcactgttg tgttcttagg agcaaacaag 61681 gaacgtacgc agaaattgtc atctgttttg gctgattatg atatcgaggc cgccatgaca 61741 gacagcaaaa aagcgcttgt tcagggacag gtctatatca tggaaggcga gctccaatcg 61801 ggatttgagc tgccgttaat gaagcttgcc gttatcacgg aagaagaact gttcaaaaac 61861 cgtgtaaaga agaagccgcg aaaacagaag cttaccaatg cagagcgcat caaaagctat 61921 tctgagcttc aaattggaga ttatgtcgtt catattaatc acgggatcgg aaaatacctg 61981 gggattgaaa ctcttgaaat caacggcatt cataaagact atttaaatat acattatcag 62041 ggcagtgaca agctttacgt ccctgtagaa caaattgatc aggtccaaaa atatgttggc 62101 tccgaaggaa aagagccaaa gctgtataaa ttaggcggaa gtgaatggaa gcgggtcaag 62161 aaaaaagtag agacatccgt tcaggatatt gctgatgact taattaagct gtatgccgaa 62221 agagaagcga gcaagggcta tgcgttttct cctgaccatg agatgcagcg tgaattcgaa 62281 tcggctttcc cttatcaaga gactgaggat cagctccgtt ctattcacga aatcaaaaaa 62341 gacatggaaa gagaacgtcc gatggaccgc ttgctgtgcg gagatgtggg ctacggtaaa 62401 acagaggttg ccatacgtgc cgcgtttaag gcgatcggtg acggaaagca ggtagctctg 62461 ctcgttccga caaccatttt ggcacagcag cactatgaaa ccataaaaga gcgcttccag 62521 gactatccga ttaatatcgg ccttctcagc aggttcagaa cgagaaaaga agcaaacgaa 62581 acaatcaaag ggctgaaaaa tggaacggtt gatatcgtca tcgggacgca tcggctgcta 62641 tcaaaggatg tcgtgtataa agacttaggg ctcctcatca ttgatgaaga gcagcgtttc 62701 ggtgtaaccc ataaagaaaa gatcaagcaa ataaaagcca atgttgatgt attaacgtta 62761 acagcaacgc cgattccgcg tacgctgcat atgtctatgc ttggcgtaag ggacctttca 62821 gtcatcgaga ctccgccgga aaatcgcttc cccgtacaga cgtatgttgt ggaatataac 62881 ggcgctcttg tcagagaggc gattgaacgt gagcttgcac gcggaggcca ggtctatttc 62941 ttgtacaacc gggtagagga cattgagcgg aaagcggatg aaatttcaat gctagtccct 63001 gacgcgaagg tagcatatgc gcatgggaaa atgacagaaa atgaattaga aaccgttatg 63061 ctaagcttcc ttgaaggaga atcagacgtt ctcgtcagca caaccattat cgaaactggc 63121 gtggacatcc caaacgtcaa tacgctgatc gtatttgacg ccgacaagat gggactttct 63181 cagctttacc agctgcgggg gcgtgtcggc cgttctaacc gtgtggcgta tgcgtacttc 63241 acgtatcgcc gggataaagt gctgacagaa gtggctgaaa aaaggctgca ggctattaaa 63301 gaattcacag agttaggttc cggttttaaa atcgcaatgc gtgacttaac gattcgcgga 63361 gccgggaatc ttcttggtgc ccagcagcat ggcttcatcg attcggtcgg atttgacctc 63421 tattcacaaa tgctgaagga ggccattgag gagcgtaaag gagacacagc gaagacagag 63481 cagtttgaaa cagaaattga tgtcgagctt gatgcgtata ttccggaaac ttatattcaa 63541 gacggcaaac agaaaattga tatgtataaa cgcttcaggt ctgtggcgac aatcgaagag 63601 aagaatgagc ttcaagatga aatgatcgac cgctttggaa actatccaaa agaagtcgaa 63661 tacttgttta ctgttgcaga aatgaaagtc tatgcgagac aggaacgtgt cgagctgatt 63721 aagcaggata aagatgctgt cagattgacg atttctgaag aagcaagtgc tgaaattgac 63781 gggcagaagc tgtttgagct tggcaatcaa tatggcagac aaatcggact gggaatggaa 63841 gggaaaaaac tcaaaatctc catacagacg aaaggccgta gtgctgatga atggctcgac 63901 accgtgctgg gcatgctgaa gggcttaaaa gatgtgaaaa agcaaaccat ttcatcaacg 63961 taaattttgt tactctctgg tgtatattac atttgatgtg acggatacta atttcaagcg 64021 aggcggaagg tacataaagt aactgcttta ggtctttccc acatgtatat accatcaaat 64081 gaaagagagg caccagagat gaaagcaacc ggtatcgtac gtcgtattga tgacttaggt 64141 cgggtcgtga ttcctaaaga aattcgaaga actctgagaa tcagggaagg cgatccgctt 64201 gagatttttg tagatcgtga cggagaagtg attttgaaaa agtactctcc gatcagtgag 64261 cttggagact ttgcaaagga gtatgcagac gcgctttacg acagcctcgg ccattcagtg 64321 ctgatttgtg atcgtgatgt atatattgcc gtgtccggca gctccaaaaa agattactta 64381 aacaagtcaa tcagcgaaat gctggaaaga acaatggatc agcgcagctc cgtgcttgag 64441 agtgatgcga aatcagtaca gcttgtgaat ggaattgatg aggacatgaa ttcttatact 64501 gtaggcccaa ttgtggcgaa cggtgatccg ataggtgctg tggtgatctt ttcaaaagat 64561 cagacaatgg gcgaagtaga gcataaagcc gttgaaacag cagctggatt tttggctcgt 64621 caaatggaac agtaggtctt attcctttct tcgaaaatag gtatgtaaag aacagctctc 64681 cttgggacgc tgttcttttt catgcgtgcc gaaaaaggaa tccaagggtt gggatgtggt 64741 ataataacct cgtttttatt tgtgccgcgg taatacgtga accgtattgc ccctgacgtt 64801 gggaaggagc ttttggatgg acgattcaat aggcgttaaa cggcattgga tttggcaggg 64861 ggcttttgtt ttaattctgg caggcgtcat cacaaaaatt ttaagcgctg tttacagagt 64921 cccgtttcaa aacattgtcg gcgatgttgg attttatata tatcagcagg tatacccctt 64981 tcttggtatt gcggtcatgc tgtccacatc aggatttcca gtcattattt caaagctgat 65041 gaatgattat agtgaaaaaa atcatcacac catattaaaa atatcagcgt tgtttttgtc 65101 tttaatcggt attttattat ttctttgttt atatctgggt gctgttccta ttgcactctt 65161 tatgggagat tcgcatctag ccgtgttaat tcaagtggcc gcatacgcgt ttctgctttt 65221 cccatttgtc gcgttgctaa gaggcggttt tcaggggcgg cacgaaatgc tcccttcagc 65281 cttatcacag atgacagagc agtttctgcg tgttgcggtg ctcttgggtt tatcattttg 65341 gctcgtgaaa aagggagcct cgctttatac tgcgggagcg gcagccgctt caggctctct 65401 tgccggaagt ttggttgcat tgataatact ggggtttttt tggttcaaaa cgaaaagaga 65461 caaccaaacg gataggcaaa acgaaaatgt catcacaaca aaagaattga cgaaaaaact 65521 gcttttatat tcggtcacaa tttgtgtaag cagtttgctg cttttgttta tccagcttgt 65581 tgatgctttg aatttatatg cattgctttc gggtggtgag gcaagcgaag aagcaaaatg 65641 cctaaagggg atctatgatc ggggacaacc cttgttgcag ctcggttcag tttttgccgt 65701 aagcattgcg acgtcactcg ttccgtatat ttctatggct gtaaaaaaca aagagctgaa 65761 gatcatgaaa gaaaaaatca cgtcatcttt gaaactatgc cttgtgctcg gtacaggcgc 65821 atcggctggg ttgatttgca ttctaaagcc ggtaaatatc atgctgtttc aaaatggaga 65881 agggacaggt gcgttacaag tatttagctg ctccattttg tttgcatcct tggcggtaac 65941 ggcagcggca gtcttacagg gagcgggata cacagttttt cctgcgatag cggtgggcgc 66001 gggtgttgcg gtgaaatggg tgttaaacac acttttggtt ccgcgctatg ggattgaagg 66061 cgcatcgctt gcgacagcgg cttcctttgc ggctgtcgcc ggccttaact tgtatcagct 66121 tcggcaaaag gaatggctcg ataagcttag aggcgttttg attccgatta ttggatctgc 66181 tcttttgatg tcagctgttt tgcttgcgta tacgcgtctc tggactttct tgtttcctgc 66241 aacaggaaga ggagcggctg tgattgagag tctttctgct gttgccattg gtggcgcggt 66301 gtttatttat tgtatgatga gattgggaat atttacagat gaagagctga acagtgtgcc 66361 attcggcagc aagttaagca aattcatgag aaggagagaa caaaatggcg ggtaaaatta 66421 cagtcgtcgg acttggtgcc ggagacatgg accaattgac aattggtata cacaagctgc 66481 tgacgaaggc agatacgctg tatgtcagaa ccaaggatca tcctttaatt gaggagcttg 66541 aaaaagaaac gaagaacatc cgtttctttg atgatatata tgagaaacat gatcagttcg 66601 aggcggtata tgaagaaatt gcagatatcc tctttgaagc ggcgcggcgt gaggacgtgg 66661 tttacgctgt gccgggacac ccttttgtcg cagaaaaaac agttcagctg ctgacggagc 66721 ggcaggaaaa ggaaaacgtt caagtgaaag tcgcgggggg acaaagtttc cttgatgcca 66781 cattcaatgt cttgcaaatt gacccgattg aaggttttca atttgtggat gccggcacat 66841 tgtccgcgga tgagcttgag ctcagacatc atctgatcat atgtcaggtt tacgaccaaa 66901 tgacggcttc tgaagtcaag ctgacattga tggagaagct gcctgatgat tatgaggtcg 66961 tcattgtgac tgcagcaggc agccgtggcg aggagatcag gacagtgcca ttatttgagc 67021 tggaccgcaa tgtcgctttg aacaacttaa caagtgtgta tattccgccg attaaagaag 67081 agaagctgct ttatcacgaa ttctccacgt tccgaagcat catcagagag cttcgcggac 67141 ctaatggatg tccgtgggat aaaaagcaga cgcatcagtc attaaagcag tacatgattg 67201 aagaatgtta tgagcttctc gaagctattg acgaagaaga cacagaccat atgatcgaag 67261 agcttggcga cgttttgctt caggtcttgc ttcacgcgca aattggtgaa gatgaaggtt 67321 atttcacaat tgatgatgtc ataaaaggaa tcagtgaaaa aatggtccga agacatcccc 67381 atgtgtttaa agatgttaag gttcaggatg aaaacgatgt tttagccaat tgggaagata 67441 taaaaaaggc cgaaaaaaat acatctgaat catcattact agacagcgta ccgaaaaccc 67501 ttccagctct ttcgaaagca gctaaattgc agaaaaaagc agcgaaggtc ggttttgact 67561 gggaagacgt cagcgatatt tgggaaaagg taagtgagga aatgaaggaa ttttcttctg 67621 aggtttctga agctcctcac gaacacaatc ttaaagctga gtttggcgac attttgttcg 67681 cgctggtgaa tgtagcccgc ttctacaaaa tagagccaga ggaagcgctg accatgacta 67741 atgacaaatt ccggagacgg ttctcgtaca ttgaggaaac agcgaaggaa gagggagtcg 67801 agttggctga tatgtccctt gaggacatgg acaaactgtg gaatgaagca aaagaaactg 67861 agaggagatc atagatatga gattagataa atttttgaaa gtatcacggc tgatcaaacg 67921 gcgtacacta gcgaaggaag tagctgacca aggacgaatc tctattaacg gaaaccaagc 67981 taaagctagc tctgacgtaa aaccgggaga tgaactaacg gtccgcttcg gccaaaagct 68041 tgtaacggtt caagttaatg aattgaaaga cacgacgaaa aaagaagaag ctgcaaacat 68101 gtacacgatt ctaaaagaag aaaaactcgg cgaataggct tgttctaaaa aaacccccca 68161 cctcatacaa tgcagtaata atgctaaaag tatcgaggat atgggggctg aatagatgaa 68221 ttcatattat gatcaaaaag gttcttcgtc tgttccggaa cagcatgatg tgacaatgaa 68281 aggccggaag catttagata tttctggggt taagcatgtg gagagttttg ataacgaaga 68341 attcctgctg gaaacggtga tgggaatgct ctccgtcaga ggccaaaacc tgcagatgaa 68401 aaatcttgat gtggaaaaag ggattgtttc gattaaaggc agggtatttg atttagtgta 68461 cttagacgaa caacaagggg ataaagctaa agggtttttt agcaagttgt ttaaatgacg 68521 ctgacgacac aattctatac aatgctagcg atgtccggta tgggtctctg gcttggtgct 68581 tcgcttgata cataccggct ctttgtcatt cgtgccaaaa cagccagatg gctattattt 68641 attcatgata ttcttttctg gattatgcaa gggctgcttt tcttttatgt cttgcttcat 68701 gtaaatgagg gagaattcag gatttacatc tttttagcgg ttctgctggg cgttgcgacg 68761 tatcagagcc tttgcaaacg aatctatata aaaatactga aattcgtcat ttaccttgtt 68821 gtttctgttt atcaattctt caaaaaactc attcagcacg tgttatttcg tcctattgtg 68881 tggacatgcg gagcgatcat ctggctggcg gcatttttat tcaagaaaac atacagcctg 68941 ataggttttc tcctgctgtg tctatataaa atagtcatgg ttctgtgttt tccgatccgt 69001 tttatcgcga aacaatgttt gaaacttctt cctgtgaaaa tgcgtctaac ttttagacgt 69061 tattttgaaa aaggtgcagg atttctcaaa aagaagaaga aactattgat aaccataaga 69121 acgaccatca cacggttttt gaagagatga aaggaggacc gtctggtttg aatttttcca 69181 gggaacgaac gataactgaa atacaaaacg actataaaga acaagtagaa cggcaaaatc 69241 agctgaagaa acgaagacgc aaagggctgt acagacggtt aactgtattc ggcgccctag 69301 tattcctgac ggcaattgtg ctggcaagct ctgtatggtc ccaaacatct tcccttagtg 69361 caaaagaaga aaagaaagaa cagcttgaaa aagaactgaa aagtttaaag acaaaacaaa 69421 cggatttaaa agaagaaata tccaaattga aggatgagga ttacgtcaca gagcttgcca 69481 gaagggactt attcatgtct ggagacggag aaattatctt caatgtggag aagaagagca 69541 agtagccttg ttgacactta aatttttatt taggtataat taagcaaacg atctttttat 69601 aagcctaagg aggagcactt tttttatgtc gattgaagtt ggcagcaagt tgcaagggaa 69661 aattacaggt attacaaatt ttggagcatt tgttgaattg cctggaggct caaccggtct 69721 cgttcacatt agtgaggtag ctgataatta tgtcaaagac attaacgacc acttaaaagt 69781 cggcgaccaa gttgaagtga aagtcatcaa cgttgaaaaa gacgggaaaa ttggtttatc 69841 tattaaaaaa gctaaagacc gtccgcaagc cagacctaga aatgatttcc gtccgaaaga 69901 atcttttgaa cagaaaatga ataagttttt aaaagacagc gaagatcgct tgtcatcttt 69961 aaaacgcaat acggaatcaa aacgtggagg gcgcggagca agaagaggat aacttgctgc 70021 tttctataaa ataaatgaag catccgttca tcccgacgga tgctttttta ttatcctcat 70081 tctctttaag agtcagaaaa ttacaacatt aaagtttctg ttgacgaaag agacaaacct 70141 ttgtattata taacttgtgc ttagaagcac aaaacaatat ggcggtgtag ctcagctggc 70201 tagagcgtac ggttcatacc cgtgaggtcg ggggttcgat cccctccgcc gctaccatat 70261 ttgtttggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 70321 cgaatcccgt acgggtcatc ctaacaaatc ggtttctctt gcagaagccg atttttttca 70381 tttttagaca acattccgga aattcttttc ataaacgaat atcaaggcag aaaccgtcga 70441 agatttcttt ggtattgtta ccttcttttg acaaaatcct atctgtgctt tcgctataat 70501 gacaggcaac gaatataaca ggtgggagat gagaggaatg gaaaaagcag aaagaagagt 70561 gaacgggcca atggcgggac aagctttgga aaaactccaa tcgtttttta acaggggcac 70621 gaagctggtg actcatcatt tgcattcact gtttttctat aaaggattca tttatgttgt 70681 catcggattt ttgcttggac gggctttcat attatccgag gtgcttcctt tcgcacttcc 70741 tttctttgga gcgatgcttc ttatcagaag agacaaagcg ttttatgcgg ttttggctgt 70801 gcttgcaggt gcgctgacca tatctccaaa gcactcattg ctcatactgg cggcattgct 70861 ggcattcttc gtattttcta aagtggctgc cttcattacc gacgatcgtg ttaaagcgct 70921 cccgattgtc gtgttcttct ccatggctgc agcaagagcc gggtttgttt atgcccaaaa 70981 tggcgtattt acaacctatg attatgtaat ggctatcgtt gaggctggac tatcgtttat 71041 cttaacactg attttccttc agagccttcc gatttttact gtgaaaaaag tgaaacaatc 71101 attaaaaata gaggaaatca tttgctttat gattcttatt gcctctgttt taacggggct 71161 ggctggcttg tcctaccaag ggatgcaggc agaacatata ttggctcgtt atgttgtgtt 71221 gagtttttcc tttattggcg gagcaagcat cggctgtacg gttggggttg tgaccggcct 71281 gattcttggc ttggcgaata tcggaaacct atatcaaatg agtctgcttg ctttttccgg 71341 tttattgggc ggtttgctga aggaagggaa aaaagcgggt gcagcaattg gtttgatcgt 71401 tggatcactt cttatatctt tatatggtga aggctctgcc ggtctgatga caacgctcta 71461 tgagtcatta atcgcagtct gcctgttttt gctcacacct caatctatta cgaggaaagt 71521 ggcgagatat attccgggaa ctgtcgagca tcttcaagag caacagcaat acgctagaaa 71581 aatccgtgat gtcactgctc agaaggtaga ccaattctcc aatgtatttc acgcgctgtc 71641 tgaaagcttt gcaacctttt atcaagcatc agacgaacag acagatgaca gcgaagttga 71701 tctgttctta agcaaaatca cggagcattc ctgccagacg tgctacaaga aaaacaggtg 71761 ctgggtacag aactttgata aaacatatga cttaatgaaa caagttatgc ttgaaacaga 71821 ggaaaaagaa tatgcatcaa accgaaggct gaaaaaagag tttcaacagt attgttctaa 71881 atccaagcag gttgaagagc tgattgagga tgagctcgca catcatcatg cccatttgac 71941 actcaagaaa aaagtccaag acagcaggcg ccttgttgct gaacagcttt taggcgtttc 72001 tgaggttatg gccgactttt ctcgggaaat aaaaagagag cgagaacaac actttctgca 72061 ggaagagcaa atcatagaag cgcttcagca tttcggaatt gagattcagc atgtcgagat 72121 ctatagtctt gaacaaggaa atatcgatat tgaaatgacc attccgttca gcggacatgg 72181 agaaagtgaa aaaatcattg ctcctatgct ttctgacatt ctggaggaac aaattcttgt 72241 gaaagccgaa cagcactctc cgcatccgaa tggatacagc catgtcgcct ttggatcaac 72301 aaaatcatac agggtgtcca cgggagctgc tcacgctgcg aagggcggcg gccttgtctc 72361 cggtgacagc tacagcatga tggagcttgg agccagaaaa tatgctgcag caatcagtga 72421 cggaatgggc aatggcgcaa gagcgcactt tgaaagcaat gaaacgatca agcttcttga 72481 aaaaatcctt gaatcgggca ttgatgaaaa aatagcaatt aaaacgatca acagcatact 72541 gtctctaagg acaactgacg aaatatattc cacgcttgac ctatctatta tcgatcttca 72601 agatgccagc tgtaaatttt tgaaggttgg atcgacgccc agctttatca aacggggtga 72661 ccaggtcatg aaagttcaag cgagcaatct gccaatcggt attattaatg aattcgatgt 72721 ggaggttgtg agtgaacagc tgaaagcggg tgacctctta attatgatga gtgatggcat 72781 ttttgagggg cctaagcatg tggaaaatca cgacttatgg atgaagcgta aaatgaaagg 72841 gttgaaaaca aatgacccgc aggagattgc cgatttgctt atggaagaag tcatccgcac 72901 aagatccggc caaattgagg acgatatgac tgttgttgtc gtccggattg atcacaatac 72961 accgaagtgg gcatccattc ctgttccggc aatctttcaa aacaaacaag aaatttcata 73021 acgcttccgt ataaatcaaa tttcttctgg cgaagatggg aatatatgaa tctgagaatc 73081 ctcgtattct ccaggaggaa tgaatgtgaa caacggacat ttaaatcaaa ttttgctgat 73141 aacggatggc tgctcaaacc atggggaaga cccgcttgca atggctgctt ttgctaaaga 73201 gcaggggatt acggtaaatg tcattggtat aatggaagaa aatcaaattg accctgaggc 73261 aatgaaggaa gtcgaaggga ttgcacttgc cggaggaggc gtgcaccaag tcgtttatgc 73321 atctcagctt tcacaaactg ttcaaatggt aacaaagaaa gcgatgacgc aaaccttaca 73381 aggtgtagtc aatcaagaac tgaaacagat tctcggaaag aatgtggaaa tggaagagct 73441 ttctccggaa aaacgcggcg aagtcatgga agtggtagac gagcttggag aaacggtgca 73501 tcttcaggtt ttggttcttg ttgatacaag tgcaagtatg gcgccaaagc ttccaacagt 73561 aaaagaggcg ctgattgatt tgtctgtaag cctcaattcc cgaattggga ataacgaatt 73621 tgcgatgtgt atatttcccg ggaaaaaaca agaggtcgag cttgtgctga actggacacc 73681 gaagctgcaa tctctttcca cactctttgc aaagctttcg acaggcggca tcacgccgac 73741 aggtccggcg attcgtgaag cgacactgca gtttgaaaaa atacgctcaa gaaggggcat 73801 gctggcagat gatgaacgac gctttgacga gtttggcatg tagcctcaag ccgggtacga 73861 caatcaaagg caagtggaat ggaaacactt atacattgcg taaacagctt ggtaaagggg 73921 ccaatggaat tgtgtatttg gcagaaacat cagatggaca tgttgcctta aaggtgagtg 73981 atgacagcct gtctattact tctgaagtga atgtcttgaa atctttctca aaggcccagt 74041 ccgttacgat ggggccttct ttttttgata cggatgatgc ctatattccc agtgccaata 74101 cgaaagtttc attttatgca atggaataca taaaagggcc gctgcttttg aagtatgtca 74161 gtgataaagg agcagagtgg ataccggtat taatgattca gctgttatcc agcttatcgg 74221 tgcttcacca gcaaggatgg atattcggcg atcttaaacc tgataatctg atcgtaactg 74281 gtccgcccgc aaggatccgc tgcattgatg tgggcggcac gacaaaggaa ggccgggcga 74341 taaaagagta tacggagttt tatgacagag gctattgggg gtatggaaca agaaaggcag 74401 agccatccta tgatctgttc gcagttgcca tgattatgat caacagtgtg cataaaaaag 74461 aatttaagaa aacgaaccag cccaaagaac agcttaggtc tctcatcgaa ggaaacccgc 74521 tgcttcaaaa gtataaaaaa gcgctttttt cagccttgaa cggagattat caatccgcag 74581 atgaaatgaa aaaggatatg ctagacgcgg ggcaaaaagc agcacaaaga aaacagccta 74641 taaaagcatc accgcagcct gccacacgac aaagacagca aaaaccgcgc caaggaaaaa 74701 taacgaagac gcgatatacc ccaaaacaga aaccggctaa gtcggggggg ttatttgaaa 74761 caacgcttat cgtgatcagt gttttagcgc tttatttcgc ctatattatc tttttcttaa 74821 tctgaatggt gcaaactgca gagcctatgc ttcttctttg cttggagggg ttgaaagtgt 74881 taggatatga atatctttaa aatacctgct cattgtgagg aggacattgt gaaaagtgtc 74941 aaagattttt taaacaaaca caatcttacg ttaaaagggg cgacaatcat tgtaggcgtt 75001 tccggcggtc cggactcaat ggctcttctt cacgcgttgc atacgttatg cggccgttca 75061 gcgaatgtta ttgcagctca cgttgaccat cggttcagag gtgcggaatc cgaggaggac 75121 atgcgttttg tccaagctta ttgtaaagct gaacagctcg tgtgcgaaac ggctcaaatc 75181 aatgtaaccg catatgcaca ggaaaaagga ctcaataagc aggctgcagc acgcgattgc 75241 cgctaccagt tttttgagga aatcatgtcg aagcaccaag cggactatct ggctcttgcg 75301 catcatggtg atgaccaggt tgaaacaatg cttatgaaac tggctaaggg tacgcttgga 75361 acgggacttg cgggaatgca gccggttaga cgttttggga cagggcggat catcaggccg 75421 ttcttaacca ttacaaagga agagatcctt cactattgcc atgaaaacgg cttgagctac 75481 cggacggatg aaagcaacgc caaagatgac tacacaagaa acagattcag aaaaacagtg 75541 ctcccgtttt tgaagcagga atctccggat gtgcataaaa ggtttcagaa agtgagtgaa 75601 gcactgacgg aagatgagca attcttacag tcattaacga aagatgaaat gaataaagta 75661 atcacaagcc agtctaatac atcagttgaa atcaattcct ctcaattgct tgccctcccg 75721 atgcctttac aaagaagagg agttcaacta atattaaact atctttatga aaacgttcca 75781 tcatcctttt cagcccatca cattcagcag tttctcgatt gggcggaaaa tggcggtcct 75841 tcaggagtac tggactttcc gaaagggctg aaggtggtca aatcatatca gacatgtttg 75901 tttacatttg aacaatggca gtgcaaaaat gttccctttg aataccaaat tagcggagct 75961 gctgatgaaa cggcagtgct ccctaatgga tatctgatag aggcaaggca ttatgcggac 76021 tcgcctgaag aacatgggaa tgctgttttt atcacaagtg aaaaaaaggt gcgatttccc 76081 ttaacaatcc ggacgagaaa agctggagac cggatcaaac taaaagggat gaacggctca 76141 aaaaaggtaa aggatatatt tattgataag aaattgcctc tccaagaaag agacaactgg 76201 ccgattgtga cggacgcaag cggtgaaatt atctggatac ctggcttgaa aaaatcaatt 76261 tttgaagatc ttgtgattcc aaacagcgac cgcattgtat tacaatatag acagcatgaa 76321 aagtgtaggg ggcaagcaaa atcatgatga aacatgatat cgagaaagta ctgatctcag 76381 aggaagagat acaaaagaaa gtaaaagagt taggtgcaga attaacgagc gagtatcaag 76441 atacatttcc gttggcaatc ggtgtgttaa aaggagcact tccttttatg gcggatctta 76501 tcaagcatat tgatacatat ttggaaatgg atttcatgga tgtatcaagc tacggaaatt 76561 ctacggtttc ttctggagaa gtaaaaatca ttaaagattt ggatacatct gtagagggcc 76621 gggacatctt aattattgaa gatatcatcg acagtgggtt aaccttaagt tatctcgtag 76681 agctcttccg ataccgtaaa gcaaaatcaa ttaagattgt tacccttttg gataaaccga 76741 gcggaagaaa agcggacatc aaagcagact ttgtcggttt tgaagttcct gacgcgtttg 76801 tagtgggtta cggacttgat tatgctgagc gctatcgcaa tctgccttat atcggagtgt 76861 taaaaccggc agtttatgaa agctgatcgg cagcctgctt ccgagatggt tattgtttgt 76921 attggaatga ttttctatgg tactattgaa catagttgtg cttactgtgg gaggaggtaa 76981 ggaatgaatc gggtcttccg taataccatt ttttatttac ttattttatt agtagtaatc 77041 ggggttgtga gctacttcca gacctcaaat ccgaaaacag aaaatatgtc gtacagtacg 77101 ttcatcaaaa acctggatga cgggaaagtt gatagcgtat cggttcagcc tgtcagaggt 77161 gtttatgagg taaaagggca gctgaaaaac tacgacaaag atcaatactt tttgactcat 77221 gttcctgaag gaaagggagc agaccagata tttaacgctt tgaaaaagac agacgtaaag 77281 gttgagcccg cgcaagaaac aagcggatgg gtgacgttcc tgacgaccat catcccattt 77341 gtcattatct ttattctgtt tttcttcctg ctcaatcagg ctcaaggcgg cggcagccgt 77401 gtcatgaact ttggcaagag taaagcgaag ctgtatacag aggaaaagaa acgcgtcaaa 77461 tttaaagacg ttgcaggggc tgacgaagaa aagcaagaac ttgttgaagt tgttgagttt 77521 ctgaaagatc cccgcaagtt tgccgagctc ggcgccagaa taccgaaagg cgtgctttta 77581 gtcggacctc cgggtaccgg taaaacattg cttgccaagg cttgtgcagg agaagccggc 77641 gtacctttct tcagcatcag cggatctgat ttcgttgaaa tgtttgtagg ggtcggtgct 77701 tcccgtgtgc gtgacttgtt tgaaaatgcg aaaaagaatg cgccttgttt gatcttcatt 77761 gatgaaattg acgcagtcgg acgccagcgt ggcgctggtc tcggcggtgg acacgatgaa 77821 cgtgaacaga cgctaaacca attgcttgtt gaaatggacg gattcagcgc taatgaagga 77881 attatcatca ttgctgcgac gaaccgtgcg gacatcttgg acccagcctt acttcgtccg 77941 ggacgttttg accgtcaaat cacagtggac cgcccagatg tcattggccg tgaagctgta 78001 ttgaaagtcc atgcgagaaa caaaccgctg gatgaaacgg ttaacctaaa atcaattgcc 78061 atgagaacac caggcttctc aggcgctgac ttagaaaacc tcttgaatga agctgcgctt 78121 gtagcggctc gtcaaaacaa gaaaaaaatc gatgcgcgtg atattgacga agcgacggac 78181 cgtgtaattg ccggacccgc taagaagagc cgcgttatct ccaagaaaga acgcaatatc 78241 gtggcttatc acgaaggcgg acacaccgtt atcggtctcg ttttagatga ggcagatatg 78301 gttcataaag taacgattgt tcctcggggc caggctggcg gttatgctgt tatgctgcca 78361 agagaagacc gttatttcca aacaaagccg gagctgcttg ataaaattgt cggcctcttg 78421 ggcggacgtg ttgctgaaga gattatcttc ggtgaagtca gcacaggggc gcacaatgac 78481 ttccagcgtg cgacgaatat tgcaagacga atggttacag aattcggtat gtcagaaaaa 78541 ctgggaccgt tgcaatttgg acagtctcag ggcggtcagg tattcttagg ccgtgatttc 78601 aacaacgaac agaactacag tgatcaaatc gcttacgaaa ttgatcagga aattcagcgc 78661 atcatcaaag aatgttatga gcgtgcgaaa caaatcctga ctgaaaatcg tgacaagctt 78721 gaattgattg cccaaacgct tctgaaagtt gaaacgcttg acgctgaaca aatcaaacac 78781 cttatcgatc atggaacatt acctgagcgt aatttctcag atgatgaaaa gaacgatgat 78841 gtgaaagtaa acattctgac aaaaacagaa gaaaagaaag acgatacgaa agagtaattc 78901 gctttctttc taaaaaaact gccggctgac gctggcagtt tttttatgta aatgattggc 78961 tcagctgcgg cttttacaat catccaattc tggtatcgat ttgtttacaa atgagccgct 79021 gatcgtgtat ggtattgtag aatgtttgta aaaagtaaag tagagaaact attcaaaagt 79081 ggtgatagag gttgttactg gttatcgatg tggggaacac caatactgta cttggtgtat 79141 atcatgatgg aaaattagaa tatcactggc gtatagaaac aagcaggcat aaaacagaag 79201 atgagtttgg gatgattttg cgctccttat ttgatcactc cgggcttatg tttgaacaga 79261 tagatggcat tattatttcg tcagtagtgc cgccaatcat gtttgcgtta gaaagaatgt 79321 gcacaaaata ctttcatatc gagcctcaaa ttgttggtcc aggtatgaaa accggtttaa 79381 atataaaata tgacaatccg aaagaagtag gggcagacag aatcgtaaat gctgtcgctg 79441 cgatacactt gtacggcaat ccattaattg ttgtcgattt cggaaccgcc acaacgtact 79501 gctatattga tgaaaacaaa caatacatgg gcggggcgat tgcccctggg attacaattt 79561 cgacagaggc gctttactcg cgtgcagcaa agcttcctcg tatcgaaatc acccggcccg 79621 acaatattat cggaaaaaac actgttagcg cgatgcaatc tggaatttta tttggctatg 79681 tcggccaagt ggaaggaatc gttaagcgaa tgaaatggca ggcaaaacag gaaccaaagg 79741 tcattgcgac aggaggcctg gcgccgctca ttgcgaacga atcagattgt atagacatcg 79801 ttgatccatt cttaacccta aaagggctgg aattgattta tgaaagaaac cgcgtaggaa 79861 gtgtatagga ggtttagtaa tggattattt agtaaaagca cttgcgtatg acggaaaagt 79921 tcgggcttat gcagcgagaa cgactgatat ggtaaatgag gggcagagac gccatggtac 79981 gtggccgaca gcatccgctg cactaggccg tacaatgaca gcttcactta tgctcggcgc 80041 tatgctgaag ggcgatgata agctgaccgt gaaaatcgag ggcggaggtc cgatcggagc 80101 tattgtagct gatgccaatg ccaaaggaga agtcagagcc tatgtctcta acccgcaagt 80161 tcattttgat ttaaatgaac aaggtaagct tgatgtcaga cgtgcggttg gaacaaacgg 80221 aacgttaagt gtcgtaaaag atttaggttt gcgcgagttc ttcacaggac aagtagaaat 80281 cgtttcagga gaattaggag atgattttac ttactatctt gtgtcatctg agcaggttcc 80341 ttcatcagtg ggcgtaggtg tgctcgtaaa tcctgacaat accattcttg cggcaggggg 80401 ctttattatt cagctgatgc cgggaacaga tgatgaaaca atcacaaaaa ttgaacagcg 80461 tctatctcaa gtagagccga tttctaagct catccaaaaa gggctgacac cagaagaaat 80521 tttagaagaa gtcctaggcg agaaacctga gattttggaa acgatgcctg tcagattcca 80581 ttgcccttgt tcaaaagaac ggttcgaaac agccatttta ggactaggca aaaaagaaat 80641 tcaagatatg atagaagaag atggacaagc cgaagcagta tgccattttt gtaatgaaaa 80701 gtacttattt acaaaagaag agctggaagg gcttcgtgac caaactaccc gctaagctct 80761 ttagcgggtt tttaatttga gaaaaggggc tgaaagcagg tttgaaatca agaacaatct 80821 ggaccattat tttaggggcg ctgttggttt gctgtattgc tgttgcatat acgctgacga 80881 aatcccaagc cggcgcatcg tcatccggtg agtctattgc gactatcgga ggcaagagtg 80941 tgacaagaga agaatggctg aaagaaatgg aagatcagta tggtaagtca acgcttgaag 81001 atatgatcaa tgtccgagtt gttgagcagc tggctaaaaa gaacaaactt aaaatatcca 81061 aaagcgaagt tgatcgtgag tttttgctga ttaaagcggt caataattcc ttttacgaag 81121 atgaacatac gacggagaaa gagtggaaag accaaattcg ttataatatc ctccttgagg 81181 atttgttaac aagggatatc gatatctcaa acaaagaatt ggaatcattc tataataaaa 81241 ataaggaact atatcagttt gatgattcgt atcgaattcg gcacattgtt gtaaaagatg 81301 aagaagaagc aagagaagtc ctgaaagaac tgaaaggcgg atcaagcttt gaagctgtcg 81361 ctgccgaaag atctacagac agatatacat caccatacgg cggagattta ggttttgtca 81421 cagaggcatc agacaacatt ccatcagcat acattgaaga ggcgaaaaca ctcaaagagg 81481 atgaatggtc tcaggaacca ataaaggtca gcaacggata tgccattatc cagctgaaag 81541 aaaaactaaa ggcaagaacg ttctcatttg atgaagtaaa ggaccagatc agacggcaaa 81601 tcgcaatgga tcagctaggc gataaagcga cagttaagac actttggaaa gaagccgatg 81661 tatcttggtt ttatggggaa aaaagtacta agtgattgac aaaaaatttt gaaattgata 81721 gattatatac ataataccaa tacaaatagt cggaaattga ggtgtcgaga atggtacgtg 81781 tagcaaactc cattactgaa ttaattggga atacgccaat cgttaaatta aatcgccttg 81841 cagatgaaaa cagtgcggat gtatatctaa aacttgaata catgaaccct ggaagcagtg 81901 taaaagaccg tatcggttta gctatgattg aagcggctga aaaagaagga aaattaaaag 81961 ccggtaatac aatcattgaa ccgacaagcg gaaatactgg aatcgggctt gcaatggttg 82021 ctgctgctaa aggattaaaa gccattttgg ttatgcctga tacaatgagc atggagcgcc 82081 gcaaccttct tcgcgcatat ggtgctgagc ttgtgctgac tcctggtgcg gaaggcatga 82141 aaggtgctat taagaaagct gaagagcttg ctgaaaagca cggatacttt gtgccgcagc 82201 agtttaacaa cccttctaac cccgaaattc accgccaaac aacgggtaaa gaaatcgttg 82261 agcaattcgg tgatgatcag cttgacgcat ttgtagccgg aatcggaacg ggcggaacga 82321 ttacgggagc gggcgaagtg ctgaaggaag catacccttc catcaagatt tatgctgttg 82381 aaccgtcaga ttccccagtg ctttcaggag gaaaaccagg cccccacaaa attcagggaa 82441 tcggagcagg attcgtgccg gacatcttaa acactgaagt atatgatgaa atcttccctg 82501 tgaagaatga agaagcattc gaatatgccc gcagagctgc acgtgaagaa ggaattctcg 82561 gaggcatctc atcaggtgcg gcaatttatg ctgctcttca agtagcaaaa aaactcggaa 82621 aaggcaaaaa agtattggcc atcattccaa gtaacggcga acgttatcta agcacgccgc 82681 tgtaccaatt cgattaaaaa aagccaaaac tcccggttcg ccgggagttt ttttatattt 82741 cgtgcatcaa atatgccatg tctgcgacga atgttattct tggaagagaa attcactttt 82801 ttcactaaca acattgcttt acaattaaaa acaagtaaaa aagaaaatag aggaatgata 82861 caaatggcac aacgcagacc ggcaggcaaa aaaatacctt ttcaaaaaga ctcattctta 82921 caacaatttg agaaacttgc gcaatcccgg aaacatcatg tacttctcga aagtgcaaga 82981 ggcggcagat atagtatagc cggtcttgat ccaattgcga ctgtgaaagg aaaagacgga 83041 ataactacaa ttaagcatgg tgatgagatg ctgtttaaag aaggtgatcc attacgggcc 83101 ttccacagct ggtttaaaac actggaaaca gaaacgaatc atgagttccc tgactttcaa 83161 ggcggggcaa tcgggtttct cagctatgat tacgcacggt acattgaaaa ttttaaaatg 83221 ctctcattag atgatttaga aacaccagat atttattttc ttgtttttga tgatatagca 83281 gtttatgacc atcaagaaga gtctctatgg ctgattactc atgttaatgg ttctgatcag 83341 gaaacagcgg atgtgaagct atctgagtta gagcagatgt ggttgactga gcttcccgct 83401 gtcacttcgc gagagatgaa gcctgaaaca gctggttctt tcgcggcgcc atttaccgag 83461 gatgggttct cacaagctgt agagaaaatc aaacaataca ttgccagcgg agatgtgttt 83521 caagtcaatc tatcaataag gcagtcacag tcactgtctg tccacccata tcaaatttac 83581 aaaaccttga gagaagtaaa tccttctcct tatatggcgt atttagaaac acctgatttc 83641 caaatcattt gcggatcgcc tgaactgctt gtcagcaaaa agggcaagct attagagacg 83701 agaccgattg cgggcacccg ttccagaggg aaaacaaatg aagaagacga ggcgcttgca 83761 aacgaattga tacacaatga aaaagaacgc gcggaacatg tcatgctggt tgatcttgag 83821 cgaaatgatc tgggaagagt atcacgttac gggtctgtgc gcgtaaatga attcatggca 83881 attgaaaaat actcgcatgt gatgcacatt gtgtctaatg tccaaggtga actgcaggat 83941 gggtatgatg ctgtagatat tattcatgct gtgtttcccg gaggaaccat tactggtgca 84001 ccgaaagtaa gaacgatgga aattatagaa gaacttgagc cgacacgccg agggctttat 84061 actggatcta taggatggtt tggatataat cacgatctgc agtttaatat cgtcattcga 84121 accatttatg caaccggagg gcaggcattt atgcagtccg gtgcaggagt tgtgattgat 84181 tctgttccga agcacgaata caaggaatca ttcaaaaaag cttttgcgat gcaaagagca 84241 ttagagctga gcgaagaaga gacaaaaatt agatgaggtg agcggagaaa tgattttaat 84301 gattgataac tacgattcat tcacgtacaa cttggtacag tatttgggcg agcttgggga 84361 agagctggtt gtgaaacgca atgacagcat cacaatcgat gaaattgaag aactgtctcc 84421 ggactttctg atgatatctc ccggaccgtg cagccctgat gaggcgggaa tcagcctcga 84481 agcaattaaa catttcgcag ggaaaattcc tattttcggt gtatgtctcg gacatcagtc 84541 catcgcacaa gtgttcggtg gtgatgttgt tagggcagaa cggcttatgc acgggaaaac 84601 ctcggatatc gagcatgacg gcaaaaccat ttttgaaggg ttgaaaaatc cccttgttgc 84661 gacgcgatac cactcgctga tcgtaaaacc tgagacgctg ccaagctgtt ttacagtaac 84721 agcacaaacg aaagaaggag aaatcatggc tattcgccac aatgacctcc cgatagaggg 84781 tgtgcaattt cacccagagt ctattatgac ctcctttggg aaagaaatgc tcagaaattt 84841 tattgagaca tatcgcaagg aagttattgc gtgatgatat atgtgaacgg ccggtatatg 84901 gaggagaaag atgcagttct ttctcctttt gaccatgggt ttttatatgg gatcggtgtt 84961 ttcgaaacct tcaggctcta cgaaggctgc ccgtttttgc ttgattggca tatagagagg 85021 cttgaacgcg cgcttaagga tctgcaaatc gaatatactg tttcaaagca tgagatcctt 85081 gagatgctgg acaagctgct taagctaaat gatatcaagg atggcaatgc ccgcgtcaga 85141 ctgaacatat cagcgggaat cagcgataaa ggctttgtcg cccagacgta cgataagccc 85201 accgttttat gctttgtgaa tcagctgaaa ccagaaagtc ttcctttgca aaaagaagga 85261 aaggttttat cgatacggag aaacactcca gagggatcgt tccggttaaa atctcatcat 85321 tatctaaata atatgtatgc gaaacgggaa attggaaatg atccgcgtgt cgagggaatt 85381 ttcttaacgg aggatggagc tgttgcagag ggtatcatat ctaatgtctt ctggagaaaa 85441 ggtcgctgta tctatacgcc atcgcttgat accggtattc tggacggcgt cacgagacgt 85501 tttatcatag aaaatgcaaa ggatatcggc ctggagctca aaacgggccg atatgagcta 85561 gaagctctct tgacagctga cgaagcgtgg atgacgaact cggttcttga aatcatcccg 85621 tttactaaaa tagaagaagt aaactatgga agccaaagcg gagaagcaac ctccgctctt 85681 caattgttat acaaaaaaga aataaagaac atgattcatg aaaagggagg aagagcatgg 85741 cgcagcacac aatagatcaa acacaagtaa tccacactaa gcccagcgct ttatcatata 85801 aagagaagac gctggtgatg ggaattttaa acgtaacgcc tgactctttc tcggacggcg 85861 gaaaatatga cagcttggac aaggcgctgc tgcacgcgaa agagatgatc gatgatggtg 85921 cccatatcat tgatattgga ggggaatcga caaggcctgg cgctgagtgc gtatctgagg 85981 atgaggagat gtccagagtc attccggtga ttgagcggat tacgaaagag cttggtgttc 86041 ctatttctgt agacacgtac aaggcttctg tcgcagatga agcagtgaaa gccggtgcat 86101 ccattatcaa tgatatttgg ggagccaaac atgatccgaa gatggcttcc gttgcagctg 86161 aacataatgt tccaattgta ctcatgcata accgccctga aagaaactac aatgacttat 86221 tgccggatat gctgtcggac ttaatggaga gtgtaaaaat tgctgttgag gccggagtag 86281 acgagaagaa cattattctt gatcctggta tcggtttcgc gaaaacctat cacgataact 86341 tggcagtgat gaacaaacta gagattttca gcggattggg atatccggtt cttctggcaa 86401 cctcccgaaa aagattcatc ggacgtgttc tggatcttcc gcctgaggag cgggctgagg 86461 gcacaggcgc gactgtgtgt ctcggcattc aaaaaggctg tgacattgtc agggtccatg 86521 atgtaaagca aattgccaga atggcgaaaa tgatggacgc gatgctgaat aagggagggg 86581 tgcaccatgg ataaagttta tgtagaaggt atggagtttt acggatatca cggtgtgttc 86641 acagaagaaa acaaacttgg ccagcggttt aaagtcgatt taaccgctga gctggattta 86701 agcaaagctg gacagacaga cgaccttgag caaacgatca actatgctga gctctatcac 86761 gtatgtaaag atatcgtgga aggggagcct gtgaaattgg tggaaacgct ggcggaacgt 86821 attgctggca ctgttctcgg aaaatttcag cctgttcagc aatgtacggt gaaagtgatt 86881 aagccagacc cgccaattcc cggacactat aaatcagtag caattgaaat tacgagaaaa 86941 aagtcatgaa caacatagct tatattgcac ttggatctaa tattggagat agagaaacgt 87001 atttaaggca agcagtggct ttactgcatc agcatgctgc ggtgacagtc actaaagtgt 87061 cgtctattta cgaaactgac ccggtcggat acgaagatca agctcaattt ttgaatatgg 87121 ctgttgaaat caagacatca ttgaaccctt ttgaactcct tgaactgacg cagcagatag 87181 aaaatgaatt aggcagaaca agggaagtaa gatgggggcc gcggacggca gaccttgaca 87241 ttttgttatt taatcgtgaa aatattgaaa cagagcaact aattgttccg catccgagaa 87301 tgtatgagcg tttgtttgtc cttgcgccgc ttgcggaaat ttgccagcag gttgaaaaag 87361 aggctacaag cgccgaaaca gaccaagaag gtgtaagagt atggaagcag aaatctgggg 87421 tagacgaatt cgtgcattca gaaagctgaa aggttatact caagaaggat ttgcaaaagc 87481 attaggtata tcagtttcta ttctcggcga aattgaacgc ggaaaccgat tgccgtctgc 87541 tgccatcatt caagatgcag cagatgtttt aaatataagt gcggacgaat tggcgccgcc 87601 agaaaaatag aacaaatgaa aggaggagaa aaattgttca aaatcggaga tattcaattg 87661 aaaaaccggg ttgtgctcgc acctatggct ggtgtctgca actctgcgtt cagattgact 87721 gtaaaggaat tcggagccgg attggtatgc gctgaaatgg tcagtgacaa agcgatcctt 87781 tacaacaatg caagaacaat gggtatgctt tatattgatg aacgtgagaa accactgagc 87841 cttcaaattt tcggaggaaa aaaggaaacc cttgtggaag cggcgaagtt tgtagaccaa 87901 aacacaactg ctgatatcat tgatattaac atgggatgtc ccgtgccgaa gattacaaaa 87961 tgcgatgcgg gagccaaatg gcttctcgat cctgataaga tttacgaaat ggtttctgca 88021 gtagtggatg ctgttaataa gccagttaca gtgaaaatga gaatgggctg ggatgaagac 88081 cacattttcg cagtgaaaaa tgcacaggct gtagaacgtg cgggcggtaa agcagtggcg 88141 cttcacggcc gtacgagagt gcagatgtac gaaggaacgg caaactggga tatcatcaaa 88201 gaagtaaaac aatcagtatc gattccggtt atcggaaacg gcgatgttaa gacaccgcag 88261 gatgctaagc gtatgctcga tgagacagga gtagacgggg tcatgatcgg acgcgctgca 88321 ttgggtaacc cgtggatgat ttaccgtacg gttcagtatc ttgaaacagg taaattaaaa 88381 gaagagccgc aagtacgcga aaaaatggcc gtatgcaaac tgcatcttga ccgcctgatt 88441 gacttaaaag gtgaaaacgt agcggtaaga gaaatgagaa agcacgctgc atggtatctg 88501 aaaggcgtga aaggcaatgc gaacgttcgt aatgaaatca atcattgcga gacgagagaa 88561 gagtttgtac agcttttaga tgcatttacg gttgaagttg aggcaaaaga gcttcaaaat 88621 gcaaaagtag gataatactc acctctattt gctgctcact gctagtttta cgctggcagt 88681 ttttctgctt ttttcatgaa acaatatctg taatggagtg ataacaatga gtcaagaaga 88741 gcataaccat gaagaattga atgatcagct gcaagtcaga cgcgataaaa tgaatcagct 88801 gagagataac ggcatcgatc cattcggcgc acgttttgaa agaactcatc agtctcaaga 88861 agttatttcg gcatatcaag atctaaccaa agaagagtta gaagaaaaag cgattgaagt 88921 tacaatcgca ggccgcatga tgacaaaacg cggcaaagga aaagccggct ttgcccatct 88981 tcaggattta gaaggccaaa tccaaatcta cgtaagaaaa gacagtgtcg gtgacgacca 89041 atatgaaatc ttcaagtctt ctgacctcgg tgatcttatc ggcgtaaccg gaaaagtctt 89101 caaaacaaat gtaggcgaat tgtctgttaa agcaacttcc tttgaattgc tgacaaaagc 89161 gcttcgtccg cttcctgaca aataccatgg tttaaaagac gttgagcagc gctaccgtca 89221 gcgctatctg gatcttatcg taaacccaga cagcaaacat acgttcatta cacgaagcaa 89281 gatcattcaa gctatgagaa ggtaccttga tgatcatgga tacttagaag tagaaacacc 89341 tacaatgcac agcattcctg ggggagcttc tgcacgtccg tttatcactc accacaacgc 89401 gttagacatt ccactctata tgcgtattgc tatcgaactg cacctaaaac gtctaattgt 89461 cggcggttta gaaaaagtat atgaaatcgg ccgtgttttc cgtaacgaag gtgtctctac 89521 acgccataac cctgaattta caatgattga gttatatgaa gcatatgcgg actataaaga 89581 tatcatgagc ttaactgaaa accttgtcgc tcatatcgcc caagaagtgc ttggcacaac 89641 tacgattcaa tacggggaag agcaaatcga ccttaaaccg gagtggaaaa gaatccatat 89701 ggttgacgca gtcaaagaag cgaccggcgt tgatttctgg gaagaggtta ctgttgagca 89761 ggcgcgtgaa tatgcaaaag aacatgaagt agaaattaaa gactctatga cagtaggcca 89821 tatcatcaac gaattcttcg aacaaaaaat tgaagaaacg cttattcagc caacgtttat 89881 ttacgggcat cctgtagaaa tttctcctct tgctaagaaa aaccctgagg acccgcgttt 89941 tacagaccgt tttgagctgt ttatcgttgg ccgtgaacat gccaacgcgt ttacagagct 90001 gaatgatcct attgatcaaa gagaacgctt tgaagcgcaa ttaaaagagc gtgaagccgg 90061 taatgatgaa gctcatttaa tggatgaaga ctttgttgaa gctctggaat acggtatgcc 90121 gccaacagga ggtttaggca tcggtatcga ccgtctggtt atgctgctga cgaatgcccc 90181 ttctattcgc gatgtgctgt tattcccgca aatgagacaa cgctaataaa aaagagcggt 90241 atcctccata gggaaaggat gccgctcttt ttaaatccct tagtatttct tcaaaaaaac 90301 tattgcacta ttatttacta ggtggtatat tattattcgt tgccgctaaa caaggcgata 90361 acgaaaaaaa gaacttcaaa aaaagttatt gacttcactg agtcaacgag ttataataat 90421 aaagtcgctt gaacgaagtg aacaaaatga tctttgaaaa ctaaacaaga caaaacgtac 90481 ctgttaattc agtttttaaa aatcgcacag cgatgtgcgt agtcagtcaa actactttat 90541 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 90601 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 90661 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 90721 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttgcaga tggacccgcg 90781 gcgcattagc tagttggtga ggtaatggct caccaaggca acgatgcgta gccgacctga 90841 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 90901 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 90961 tttcggatcg taaagctctg ttgttaggga agaacaagtg ccgttcgaat agggcggtac 91021 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 91081 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 91141 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 91201 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 91261 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 91321 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 91381 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 91441 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 91501 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 91561 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 91621 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 91681 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 91741 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 91801 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 91861 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 91921 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 91981 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 92041 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatatttta 92101 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 92161 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaagt 92221 aatacaagat atcacatagt gattcttttt aacggttaag ttagaaaggg cgcacggtgg 92281 atgccttggc actaggagcc gatgaaggac gggacgaaca ccgatatgct tcggggagct 92341 gtaagcaagc tttgatccgg agatttccga atggggaaac ccaccactcg taatggagtg 92401 gtatccatat ctgaattcat aggatatgag aaggcagacc cggggaactg aaacatctaa 92461 gtacccggag gaagagaaag caaatgcgat tccctgagta gcggcgagcg aaacgggatt 92521 agcccaaacc aagaggcttg cctcttgggg ttgtaggaca ctctgtacgg agttacaaag 92581 gaacgaggta gatgaagagg tctggaaagg cccgccatag gaggtaacag ccctgtagtc 92641 aaaacttcgt tctctcctga gtggatcctg agtacggcgg aacacgtgaa attccgtcgg 92701 aatccgggag gaccatctcc caaggctaaa tactccctag tgaccgatag tgaaccagta 92761 ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga aagagatcct gaaaccgtgt 92821 gcctacaagt agtcagagcc cgttaacggg tgatggcgtg ccttttgtag aatgaaccgg 92881 cgagttacga tcccgtgcaa ggttaagcag aagatgcgga gccgcagcga aagcgagtct 92941 gaatagggcg catgagtacg tggtcgtaga cccgaaacca ggtgatctac ccatgtccag 93001 ggtgaagttc aggtaacact gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg 93061 atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga gatagctggt tctctccgaa 93121 atagctttag ggctagcctc aaggtaagag tcttggaggt agagcactga ttggactagg 93181 ggcccctacc gggttaccga attcagtcaa actccgaatg ccaatgactt atccttggga 93241 gtcagactgc gagtgataag atccgtagtc gaaagggaaa cagcccagac cgccagctaa 93301 ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt 93361 ggcttagaag cagccaccat ttaaagagtg cgtaatagct cactggtcga gtgactctgc 93421 gccgaaaatg taccggggct aaacgtatca ccgaagctgc ggactgttct tcgaacagtg 93481 gtaggagagc gttctaaggg ctgtgaagcc agaccggaag gactggtgga gcgcttagaa 93541 gtgagaatgc cggtatgagt agcgaaagag gggtgagaat cccctccacc gaatgcctaa 93601 ggtttcctga ggaaggctcg tccgctcagg gttagtcggg acctaagccg aggccgaaag 93661 gcgtaggcga tggacaacag gttgatattc ctgtaccacc tcctcaccat ttgagcaatg 93721 gggggacgca ggaggatagg gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc 93781 tgggaaatag gcaaatccgt ttcccataag gctgagctgt gatggcgagc gaaatatagt 93841 agcgaagttc ctgattccac actgccaaga aaagcctcta gcgaggtgag aggtgcccgt 93901 accgcaaacc gacacaggta ggcgaggaga gaatcctaag gtgatcgaga gaactctcgt 93961 taaggaactc ggcaaaatga ccccgtaact tcgggagaag gggtgctctg ttagggtgca 94021 agcccgagag agccgcagtg aataggccca ggcgactgtt tagcaaaaac acaggtctct 94081 gcgaagccgt aaggcgaagt ataggggctg acgcctgccc ggtgctggaa ggttaagagg 94141 agcgcttagc gtaagcgaag gtgcgaattg aagccccagt aaacggcggc cgtaactata 94201 acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc gacccgcacg aaaggcgcaa 94261 cgatctgggc actgtctcaa cgagagactc ggtgaaatta tagtacctgt gaagatgcag 94321 gttacccgcg acaggacgga aagaccccgt ggagctttac tgcagcctga tattgaatgt 94381 tggtacagct tgtacaggat aggtaggagc cttggaaacc ggagcgccag cttcggtgga 94441 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 94501 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 94561 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 94621 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 94681 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 94741 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 94801 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 94861 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 94921 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 94981 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 95041 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 95101 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 95161 atcgatcgag gacttaacca tatttttgaa tgatgtcaca tctgttatct agttttgaga 95221 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 95281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 95341 acgccgccaa gcaattgcac gttagtgcaa ttatggagga ttagctcagc tgggagagca 95401 tctgccttac aagcagaggg tcggcggttc gagcccgtca tcctccacca ttatgccggt 95461 gtagctcaat tggtagagca actgacttgt aatcagtagg ttgggggttc aagtcctctt 95521 gccggcacca cttttatatg atataatact caagtctctt gtagaagagc cattagctca 95581 gttggtagag catctgactt ttaatcagag ggtcgaaggt tcgagtcctt catggctcac 95641 cattttacgc gggtgtggcg gaattggcag acgcgctaga cttaggatct agtgtcttta 95701 tgacgtgggg gttcaagtcc cttcacccgc attatatagg ataacagtta gaaaaactgg 95761 acatcctgtc tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 95821 gggttcgaat cccgtcttcc gctccaacta taccatccac gccggggtgg tggaattggc 95881 agacacacag gacttaaaat cctgcggtag gtgactaccg tgccggttca agtccggccc 95941 tcggcattat gttttgcgcc cgtagctcaa ttggatagag cgtttgacta cggatcaaaa 96001 ggttaggggt tcgactcctc tcgggcgcgc catatctttt aatagaatag ataggaaatc 96061 gggaagtagc tcagcttggt agagcacatg gtttgggacc atggggtcgc aggttcgaat 96121 cctgtcttcc cgaccatttt tttatggggc cttagctcag ctgggagagc gcctgctttg 96181 cacgcaggag gtcagcggtt cgatcccgct aggctccacc aaaagttttt aaaaaagttg 96241 ttgactttga agaagtgacg ttgtatacta ataaagttgc tttaacaaag cggacaaaca 96301 aaatgatctt tgaaaactaa acaagacaaa acgtacctgt taattcagtt tttaaaaatc 96361 gcacagcgat gtgcgtagtc agtcaaacta ctttatcgga gagtttgatc ctggctcagg 96421 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc 96481 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 96541 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 96601 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 96661 acggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 96721 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 96781 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 96841 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 96901 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 96961 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 97021 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 97081 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 97141 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 97201 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 97261 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 97321 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 97381 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 97441 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 97501 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 97561 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 97621 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 97681 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 97741 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 97801 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 97861 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 97921 gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc ttgggtctta 97981 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 98041 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 98101 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 98161 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 98221 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 98281 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 98341 tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga ggcttgcctc 98401 ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg aagaggtctg 98461 gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc tcctgagtgg 98521 atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc atctcccaag 98581 gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg tgaaaagcac 98641 cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc agagcccgtt 98701 aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc gtgcaaggtt 98761 aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg agtacgtggt 98821 cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt aacactgaat 98881 ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta ggggtgaaat 98941 gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct agcctcaagg 99001 taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt taccgaattc 99061 agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt gataagatcc 99121 gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata cgttaagtgg 99181 aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc caccatttaa 99241 agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc ggggctaaac 99301 gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc taagggctgt 99361 gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt atgagtagcg 99421 aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa ggctcgtccg 99481 ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga caacaggttg 99541 atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag gatagggtaa 99601 gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa atccgtttcc 99661 cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga ttccacactg 99721 ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca caggtaggcg 99781 aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca aaatgacccc 99841 gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc gcagtgaata 99901 ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg cgaagtatag 99961 gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa gcgaaggtgc 100021 gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta gcgaaattcc 100081 ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg tctcaacgag 100141 agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag gacggaaaga 100201 ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta caggataggt 100261 aggagccttg gaaaccggag cgccagcttt ggtggaggca tcggtgggat actaccctgg 100321 ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc aggtgggcag 100381 tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt ccctcagaat 100441 ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga gacctacaag 100501 tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa gggccatcgc 100561 tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag tccacatcga 100621 cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag tcggtcccaa 100681 gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg tcgtgagaca 100741 gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct tagtacgaga 100801 ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat cgctgggtag 100861 ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc tcaagatgag 100921 atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat aggtctgagg 100981 tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact taaccatatt 101041 tttgaatgat gtcacatctg ttatctagtt ttgagagaac actctcaatt tgtttggtgg 101101 cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc tcttcagcgc 101161 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa gcttaaaccc 101221 agctcaatga gctgggtttt ttgtattttg gtttattggt atcataaaat tccacttaac 101281 tgtataatat aataacttta taccgaattt taaatcagca atcaggtttt gtggaccggg 101341 aaaatggaaa taatgaagga tagagcgaga aagttgaaaa ttctcgagaa acggcttata 101401 gtaagattaa agtcaaatat agtcaaagtc agtaaaggag ggggttgagt gggacataat 101461 atttctgaca tcattgaaca atatttaaaa cgagtgttag atcaaaatgg caaggaaatt 101521 ttagagatta aacgaagtga aattgcagat aaatttcaat gcgttccttc ccaaataaat 101581 tatgtcatca acaccagatt tacaagcgaa agaggatata ttgttgagag caaacgcggg 101641 ggcggcggtt acatcagaat cattaaaatt aaaatgaaca atgaagttgt cctgatcaat 101701 aatataattt ctcaaattaa tacccatttg tctcaagcag cctctgatga cattatttta 101761 aggctattag aagacaaggt aatttcagaa agagaagcaa aaatgatggt cagcgtaatg 101821 gaccgctcag ttttacacat tgacttacct gaacgtgatg aattaagagc gagaatgatg 101881 aaggcaatgc tgacttcttt aaaattaaaa taagcgggtg aaaagattga tttgtcaaga 101941 gtgccacgag agaccagcca cttttcactt tacaaaggtt gttaacggag aaaaaataga 102001 agttcatatt tgtgaacaat gtgccaaaga aaatagtgat tcatatggta taagtgcaaa 102061 tcagggtttc tctattcata atttactttc gggtttactg aacatggatt cttcatttca 102121 aaatgcagga actcaaatgt tcagtcactc ggagcaaata tctgcttgtc cgaaatgcgg 102181 aatgactttt cagcaattca gaaaaattgg ccgttttgga tgttctgaat gttacaaaac 102241 atttcatagc aacattacac caatcctacg taaagtgcac agcggaaaca ctgtgcatgc 102301 aggtaagata ccgaaacgaa taggcggcaa tcttcatgtc agacggcaga ttgatatgct 102361 aaaaaaggaa ttagaatcct taatccatca agaagaattt gaaaatgcag ctcatgtaag 102421 agatcaaatt cgtttattag aacaatcact caaaagtaca gatagtgagg aggaacagga 102481 gtaatgtcgc taaagcattt tattcaggac gcactaagca gttggatgaa gcagaaagga 102541 cctgaaagtg acattgtact cagcagccgc atacgtttag caagaaactt tgagcatatt 102601 cggttcccta cgcggtattc caatgaagaa gcctcatcca tcatacagca atttgaagat 102661 cagttttcag agcaagaaat tcccggaatc ggcaaatttg ttttgattag aatgaatgat 102721 gcacagcctt tagaaaagcg tgtacttgtt gaaaaacatc taatcagccc gaatttgaca 102781 gagtctcctt ttggcggctg tttgctttct gaaaatgagg aagtaagcgt catgctaaat 102841 gaagaggacc atattagaat tcagtgtctt ttccctggat ttcagctttt agaagcaatg 102901 aaagccgcaa accaggtcga cgactggatt gaagaaaaag ttgattatgc attcaatgag 102961 caaagaggat acttaaccag ctgtcctaca aacgtaggta ctggtttaag ggcttcggtc 103021 atgatgcatc tgccggcgct ggttttaact aggcaaataa atcgaattat accggcaatt 103081 aatcaattag gcttagttgt tagaggaatt tatggggaag gcagcgaagc agtagggaat 103141 atctttcaaa tttcaaatca gatcacgctt ggtaagtcag agcaggatat tgtagaggat 103201 cttaacagtg ttgctgctca gttgattgaa caagaacgat ctgcccgaga agcgatttat 103261 caaacttcta aaatcgaact tgaggatcgg gtatatcggt catatggggt cttgtctaat 103321 tgccggatga tagaatcgaa agaaactgca aagtgccttt cagatgttcg gttaggcata 103381 gacttaggca taataaaagg actttcaagc aacatactta acgaacttat gattttgacg 103441 cagccagggt ttttacagca atactcggga ggcgctttgc gaccgaacga aagggacatt 103501 cgaagagcgg ctctcatcag agaacggctt cacttagaaa tgaatgggaa aagacaggag 103561 gatgaatcga tatgatgttt ggaagattta cagaacgagc tcaaaaagta ctggcgctag 103621 cacaggaaga agcacttcgg ttaggtcata ataacattgg cactgagcat attttattag 103681 gactggtaag agaaggagag ggcattgctg ctaaagctct tcaagcgctt ggactcggtt 103741 cagaaaaaat tcagaaagaa gtagaaagtt tgatcgggcg cgggcaggaa atgtctcaaa 103801 cgattcatta tactcctaga gctaaaaaag tcattgagct ttcaatggat gaggcaagaa 103861 aactcggtca ttcttatgtg ggaacagaac atattcttct tggtctgatt cgtgaaggag 103921 aaggtgttgc tgcgagagtt ctgaataatc tcggtgtcag cttaaataaa gcaagacagc 103981 aggtgctcca gcttctagga agtaatgaaa caggatcatc agcggcagga acaaacagca 104041 atgcgaatac gcctacgctt gacagcttgg caagagactt aactgctatt gcgaaggaag 104101 acagccttga ccctgtaatc ggcagaagca aggagatcca gcgtgtcatt gaagtgttaa 104161 gccgcagaac gaaaaacaac cctgttctca ttggggaacc aggtgtaggt aaaacggcta 104221 tcgcagaagg tttggcacag caaattatca ataatgaagt acccgaaatt ttgcgtgata 104281 aacgtgtgat gacattagac atgggaacag ttgttgccgg cacaaaatac cgcggagaat 104341 ttgaggatcg cctgaagaag gtcatggatg aaattcgcca ggcaggaaat atcattctat 104401 tcatcgatga gctccataca ttaatcgggg caggcggagc agaaggtgct attgatgcat 104461 ctaatatttt aaaaccttca cttgctcgtg gcgaactcca atgtattggt gcaacgactc 104521 ttgatgagta ccgtaaatat attgaaaaag atgcagcact ggaacgccgt tttcagccga 104581 ttcaggttga tcagccatct gtagatgaaa gtattcaaat tttacaaggt ctgcgtgaca 104641 gatacgaagc ccaccaccgc gtttctatca ctgatgatgc cattgaagct gcggttaagc 104701 tttctgacag atatatttct gaccgcttcc ttccggataa agcaattgac ttgatcgatg 104761 aagcgggttc aaaggtgaga ctgcgctcat ttacaacgcc tcctaactta aaagagcttg 104821 agcagaagct tgatgaggtt cgtaaagaga aggatgcggc agtgcaaagc caagagtttg 104881 aaaaagctgc ttccttgcgt gatactgaac aacgcctgcg cgagcaagta gaggatacga 104941 agaaatcatg gaaagagaag caagggcagg aaaactcaga ggttactgtg gatgatattg 105001 cgatggttgt atccagctgg accggtgtgc ctgtatctaa aatcgcccaa actgaaactg 105061 ataagcttct caatatggaa aacattcttc actcccgtgt catcggccag gatgaagcag 105121 ttgtagcggt tgcaaaagcc gtcagacgtg caagagcagg attgaaagat cctaaacgcc 105181 caatcggctc attcattttc ttaggcccta caggtgtagg taaaacagaa cttgcacgag 105241 cacttgctga atccattttt ggcgatgaag aatccatgat cagaattgat atgtctgaat 105301 acatggaaaa acattcaact tcaagacttg ttggttcacc tccgggttat gtgggatatg 105361 atgaaggcgg tcaattgaca gagaaagtca gaagaaaacc ttactctgtc gtgcttcttg 105421 atgagatcga gaaagcgcac cctgatgtct tcaatatcct tctgcaagtt cttgaagacg 105481 gacgattgac tgattctaaa ggacgcacag tcgatttccg caataccatt ctgatcatga 105541 catcaaacgt cggagcaagt gagctaaaac gcaataaata tgtcggcttt aacgttcagg 105601 atgaaactca aaatcataaa gacatgaaag ataaagtgat gggtgaatta aaacgagcgt 105661 tcagacctga gttcatcaac cgtattgatg aaatcattgt cttccattca cttgagaaaa 105721 aacatctcac tgagattgtg tcattaatgt ctgatcaatt aacgaaacgc ctgaaagaac 105781 aagatctttc tatcgaattg acagatgctg caaaagcgaa agtcgcggaa gagggcgttg 105841 acctggaata cggtgcccgt ccgttaagaa gagcgatcca aaaacatgtc gaggatcgtt 105901 tatctgaaga actcctcaga ggaaatattc ataaaggaca gcatattgtt cttgatgtag 105961 aagatggcga atttgtcgta aaaacgactg ctaaaacgaa ttaatataga agacggaaat 106021 gaggcataca gcatgtaagt gtatgcctca ctttcatatc aagaaataga acaagggaga 106081 ggtcttacac tatatatggc taaaacaaaa tcgaagttca tctgccaatc ctgcggctac 106141 gagtctccaa aatggatggg gaaatgtccg ggctgtggtg cttggaatac aatggtggaa 106201 gaaatgatta aaaaagcacc ggccaatcgg agagcggctt tttctcattc tgttcaaact 106261 gtacagaaac cttcacctat tacatcaatc gaaacatcag aagaaccccg cgtcaaaacc 106321 cagcttggcg agtttaacag agtactcggc ggaggtgtcg ttaaaggctc cctcgtttta 106381 attggcggtg atcctggtat cggaaagtca acgctattac tgcaggtttc cgctcaatta 106441 tcaggctcat caaacagtgt cctgtatatt tcgggagaag aatctgtaaa gcaaacgaag 106501 ctgcgagcag accgtctcgg cattaataat ccgtcactgc atgttttatc tgaaaccgat 106561 atggagtata tttcgtctgc tatacaagag atgaatccat cgtttgtcgt tgttgactct 106621 attcaaacgg tttaccaaag cgatattaca tctgctccag gcagtgtgtc acaggtcaga 106681 gaatgtaccg ctgagctgat gaaaattgca aaaacaaaag gtattccgat ttttatcgta 106741 gggcacgtga cgaaagaagg gtctattgca ggtccgagac tgttggagca tatggttgac 106801 actgttttat attttgaagg agaacgccac catactttcc gtattttgcg ggctgtaaaa 106861 aaccgtttcg gatctacaaa cgaaatgggc attttcgaaa tgcgggaaga ggggctcact 106921 gaggttttga atccttcgga aattttctta gaagaacgct ctgctggttc cgcaggctcg 106981 agtatcactg cctctatgga gggcactaga ccgattctcg ttgaaattca ggcactcatc 107041 tcgccaacaa gttttggcaa cccaaggcgt atggcaacgg gaatagacca taacagggtt 107101 tctctgttaa tggctgtgtt agaaaaaaga gttggactgc tgctgcaaaa tcaggatgct 107161 tatttgaaag tggctggcgg cgttaagctt gatgaaccgg caattgatct tgcgattgtg 107221 attagtattg catcaagctt tagagacaca cctccaaatc ctgcagattg ttttattgga 107281 gaagtgggat taaccggaga agtccggcgg gtttcaagaa ttgaacagcg tgtgaaagaa 107341 gcggcaaagc ttggttttaa acgcatgatc atacccgcgg caaatctgga tggatggaca 107401 aaaccaaaag ggattgaggt tatcggagta gcaaatgttg cagaagcgct tcgtacttca 107461 ttaggaggat aatagatgga aaaagagaaa aaaggggcga aacacgagtt agacctgtca 107521 tctatattgc agtttgttgc tccgggtaca ccgctcagag cggggatgga aaacgtcttg 107581 agagcaaata caggcggtct gattgttgtt ggatataatg ataaagtaaa agaagtggtg 107641 gacggcggct ttcacataaa cacggctttt tctccggcgc atttatatga gctggctaaa 107701 atggatggag cgatcatttt aagtgattct ggtcaaaaga tcctatacgc gaatactcag 107761 ctgatgccgg atgccacaat ttcttcatca gaaacaggaa tgcggcacag aactgccgaa 107821 agagtagcta agcaaactgg ctgtcttgta atcgccattt ctgaaagaag aaatgtcata 107881 acgttatatc aggaaaacat gaagtataca ctaaaagaca taggatttat tttaaccaag 107941 gcgaaccaag ccattcaaac acttgaaaaa tataagacaa tcctcgataa aacgattaat 108001 gcactgaacg cgttagagtt tgaggaactt gttaccttca gtgatgtctt gtctgtcatg 108061 catcgttatg aaatggtact gagaatcaaa aacgaaatta atatgtatat caaagagctg 108121 gggacagaag ggcatctgat caaactgcaa gtcattgaat tgattacgga tatggaagaa 108181 gaggccgctt tatttattaa ggactatgta aaagaaaaga ttaaagatcc gtttgttctc 108241 ttgaaggagc tgcaggatat gtccagttat gatctgctgg atgattccat tgtgtataag 108301 cttctcggtt accctgcttc tactaatctt gatgattatg tattgccgag aggatacagg 108361 ctgttaaata agataccgcg tcttccgatg ccgattgttg aaaatgttgt agaagcattt 108421 ggagtcctgc caaggattat tgaggcgagt gcagaagaat tagatgaagt agagggaatc 108481 ggtgaagtac gagcccaaaa aatcaaaaaa ggattaaaac gcctgcaaga gaagcattat 108541 ttagacagac aactgtgatt tcggttaaaa ccttatgaat acgggtatat taatgttggt 108601 ttttgtttat tctgatattc gtaggatgca taagactttg tgaaattaaa atgttaaaaa 108661 aggaggtggg ggtatgttaa aacgaatagt tcaggcgttc ttcattattt ttggcggcgt 108721 tgttggtata tttttgatac ctgaattgtt tgtactgtta aatatacagg acataccttt 108781 aataacaaac gcatatacgt ctgcggcaat aggagcaatt atcttttttc tcatcagtat 108841 atggggtaca gaatacgttg tgaactgggt gaagtggata gaggattcat tgttaaaagc 108901 gccggttcca gatttgttat ttggaagtct tggcttagtt tttggactta taattgctta 108961 tcttatcgta aatgttattc ctttagacaa tataccttac cgcatattca gcacaataat 109021 tcctgtattt ttggctttct tcctcggtta tctcggcttc caggtgggct ttaagaaaaa 109081 ggatgaattg atcagcctgt tttccatttc cgccagaatg caaaagaaaa aaggaacagc 109141 tgatgaagaa catgaggttc aagacaagaa gctgaaaatt ttggacacta gtgttattat 109201 tgatgggaga atagcagata tttgtcagac tggtttttta gagggagtta tcgtgattcc 109261 gcagtttgtc cttgaggaat tgcagcatat tgcagactct tcagatgttt taaaacgaaa 109321 cagaggacgc cgcggtcttg atatcctgaa ccgcattcag aaagaattag acattgaagt 109381 tgaaatttac gaaggcgact ttgaagatat tcaggaggtt gacagcaagc tcgtcaaact 109441 tgctaagctg acatccgggg tcgttgtgac gaatgatttt aatttaaata aagtgtgcga 109501 gcttcagaag gtagcagtat taaacattaa tgaccttgcc aatgcggtta agcctgttgt 109561 gcttcctggc gaggaaatga atgttcaggt cattaaggac gggaaagagc ataatcaggg 109621 agttgcctac ttggatgacg gtacgatgat tgtcgttgaa gaaggacgga attatatcgg 109681 caagcatatt gatgtactcg tcacaagtgt gctgcagaca gcagcgggac gaatgatttt 109741 tgcgaagcct aagctgttgg agaaggcgct gtaaagggag aagaaacaat gagttatgat 109801 gtggtgattc ctgcagccgg acagggaaag cggatgaagg cagggagaaa taaactgttc 109861 attgagctga agggagaccc ggtgatcata cacacgttaa gagtgtttga cagccaccgg 109921 cagtgcgata aaatcatttt ggtgattaac gagcaggagc gggagcactt tcagcaattg 109981 ctgtccgatt acccgtttca aacttcaatt gagcttgttg caggcggaga tgagcgacag 110041 cacagtgtgt ataaggggct gaaagccgta aagcaggaaa agattgtcct tgtacatgac 110101 ggtgcccgtc catttataaa acatgaacaa attgacgaac tgatcgcaga ggcggaacag 110161 acaggagcgg ccatccttgc tgttccggta aaagatacga ttaaacgcgt tcaagattta 110221 caagtcagtg agacgattga acgttcaagc ttgtgggctg tccaaacgcc acaagctttt 110281 cgtctttctt tattgatgaa ggctcacgct gaggccgagc gcaagggatt tttagggacg 110341 gatgacgcca gcctcgttga acagatggag ggcggttcgg tccgtgttgt agaaggcagc 110401 tatacaaata ttaagctgac gacgccagac gatttgacgt cagctgaagc tatcatggaa 110461 tcagaaagtg ggaataaaca tgtttagaat tggacaagga tttgatgtgc atcaattagt 110521 ggagggccgt cctctcatta ttggcggaat tgaaatcccg tacgaaaaag ggctgcttgg 110581 ccattctgat gcagacgtat tgttgcatac cgtcgctgac gcctgcctgg gagctgtggg 110641 tgaaggagac ataggcaagc attttcctga cacagatccc gagttcaagg acgcagattc 110701 tttcaaatta cttcagcatg tctggggaat cgtgaaacag aaggggtatg tccttgggaa 110761 cattgattgc accatcatag cgcaaaagcc gaagatgctg ccgtacatag aagatatgag 110821 aaaaagaatt gctgaaggcc ttgaggcaga tgtttctcaa gtaaatgtaa aagcaacaac 110881 gacagaaaag cttggattta caggccgggc ggaaggaata gcggctcagg cgacagtact 110941 gatacaaaaa ggctaacttg ttttgatgcc gggtctattt ggtggtagaa tagattcata 111001 catttttgcc tgaggccata catgacatga aaggaagtat ttgaaaatgg gaaacgaagt 111061 acgcgtccgt tatgcaccga gtccaaccgg acatttgcat attggaaatg ccagaacggc 111121 gctttttaat tatttatttg cccgcaatca aggcggtaag tttatcattc gagttgagga 111181 tactgataaa aagcgcaata ttgagggcgg agaacaaagc cagctgaatt atctgaagtg 111241 gctaggtatt gactgggatg agagtgtgga tgtcggagga gagtacggtc cataccgtca 111301 gtcagagcgt aacgatatct ataaagtgta ctatgaagag cttcttgaaa aagggcttgc 111361 ttataaatgt tactgtacgg aagaagagct tgaaaaagag cgtgaagaac agattgcccg 111421 cggagaaatg cctcgttatt ccggaaaaca cagagacctg actcaggaag aacaggagaa 111481 atttatcgcc gaaggcagaa aaccaagtat tcgtttccgt gtgccggaag gaaaagtcat 111541 cgccttcaac gacatcgtaa aaggcgaaat ttcttttgaa tcagatggca tcggcgactt 111601 cgttattgtg aaaaaggacg gaacgcctac ttataacttc gcggtagcta ttgatgacta 111661 cttaatgaaa atgacacacg tgctgcgcgg tgaggatcat atttctaaca caccgaaaca 111721 gattatgatc tatcaagcat tcgggtggga tattcctcag ttcggacaca tgacgctgat 111781 tgtaaacgaa agccgtaaaa agctcagcaa acgtgatgaa tccattattc aattcatcga 111841 gcagtacaaa gagcttggct acctgccaga agcgctgttc aactttatcg gcttgttagg 111901 ctggtcaccg gttggagaag aagagctttt cacaaaagag cagtttattg aaatttttga 111961 tgtaaatcgt ttatctaaat caccagcttt gtttgatatg cataagctaa aatgggttaa 112021 caaccaatat gtgaagaagc tggatcttga tcaggttgtt gaactgacgc ttccgcattt 112081 gcaaaaagcc ggcaaagttg gcactgagct ttctgctgaa gaacaagaat gggttcgtaa 112141 actgatttcc ctgtatcatg agcaattaag ctacggtgcg gaaattgttg agctgactga 112201 tttgttcttt acggatgaga tcgagtataa tcaagaagcg aaagctgttc tggaagaaga 112261 acaggttcct gaagtgctca gcacattcgc agcgaagctt gaagagcttg aggagttcac 112321 tccggataat atcaaagcat cgatcaaagc agtgcagaaa gaaactggcc ataaagggaa 112381 aaaactgttt atgccgattc gtgttgctgt aacagggcaa actcacggtc cggaactgcc 112441 gcaatcaatt gaattgatcg gtaaagagac tgcaattcag cgtttaaaga atatctaaat 112501 aaatgattgt tgacagggaa gagtataaag ctttaggcca ttacagaaag gatcttcatt 112561 ggctgagaga gatccatgag ccgggtttta gaagtgcgcc cttaagacct ttgaagaacg 112621 ttttttgaaa tcagtattca aaggcggccg ccgccgttac aggctgaagt tgggagagca 112681 gaagtctgct tttcaaacag agtggaaccg cgcggttaaa gcgtctctgt catgtttaca 112741 tgcagagacg ctttttttat tgggtagagg aaatcagata gagaaacggg gggaagcatg 112801 tgttttttag aatgctcaaa gaagacattg atactgtgtt cgatcaagat cccgcagcaa 112861 gaagctattt tgaagtgatt ttaacttatt ccggtttaca tgctatatgg gcgcatcgga 112921 ttgcacatgc tttatataaa cgaaaatttt atttccttgc acgccttata tctcaagtaa 112981 gccgattttt taccgggata gaaatccacc ccggcgctac aatcgggaga agatttttca 113041 tagaccacgg catgggggtt gtcattgggg agacatgtga aatcggcaat aacgtaaccg 113101 tttttcaggg ggttaccctc gggggaacgg gaaaagaaaa gggaaaaagg cacccaacga 113161 ttaaagatga cgcattgata gccacaggtg ctaaagtgct cggttctatt acggtcggtg 113221 aaggctcaaa gattggcgct ggttcagtag tgctgcatga tgttcctgat ttttcaacag 113281 ttgtcggtat ccctggacgg gtcgttgtac aaaatggcaa gaaagtaaga cgcgatttaa 113341 accatcagga tttgcccgat ccagttgctg accgctttaa gtctttggaa cagcagattt 113401 tagagctgaa ggcagaactt gaagacagaa aagaaaggat caatcaaaaa tgacaatcac 113461 actttataat acattgacta gacagaagga aacattcgtt cctcttgaag agggaaaagt 113521 gaaaatgtat gtatgcggac ccacggttta caattacatt catatcggga acgcgcgtcc 113581 ggcaatcgtt tacgatacgg ttcgaaacta tttagagtat aaaggctatg atgtgcagta 113641 tgtctctaac ttcacagacg tagacgataa attaattaaa gcggcaaatg aactcggtga 113701 ggatgtaccc accatttcag agcgttttat taaagcatac tttgaagacg taggtgcgct 113761 cggctgccga aaagccgacc ttcatccgcg agtaatggag aacatggatg ccattatcga 113821 attcgtagat cagctcgtga aaaagggcta cgcatatgaa tcagaaggtg acgtatattt 113881 caaaaccaga gcatttgaag ggtacggaaa gctttctcag caatcaatcg atgaactaag 113941 atcaggtgca cgcatccggg tcggcgagaa aaaagaagat gctcttgatt tcgcactgtg 114001 gaaagcggca aaagaaggag aaatctcttg ggatagccct tgggggaaag ggcgtccggg 114061 ctggcacatt gaatgctcag caatggtgaa aaagtatctc ggtgaccaga ttgatatcca 114121 tgcgggcgga caggatttaa cattccctca ccatgaaaac gaaattgcgc aatctgaggc 114181 gctgacaggc aaaacgtttg cgaagtactg gcttcataat ggttatatca atattgataa 114241 tgaaaaaatg tcaaaatcac taggcaactt tgtgcttgtg catgacatca ttaaacagca 114301 tgatccgcag cttttgagat tctttatgct atctgttcat tatcgccatc cgattaacta 114361 ttcagaagag cttctggaga atacgaaaag cgcgttcagc cgtttaaaaa cagcgtacag 114421 caatcttcag caccgtctga acagcagtac gaatttaacc gaagatgacg atcaatggct 114481 tgaaaaggtt gaagaacacc gcaaagcatt cgaagaagag atggacgatg attttaatac 114541 ggcgaatgcc atttcagtct tgtttgactt agcgaaacac gccaattatt atcttcagaa 114601 agatcatacg gctgatcatg tgattacggc gtttattgag atgtttgacc gcattgtttc 114661 tgtcctcggt ttttcgttgg gtgagcagga acttctcgat caagagattg aagacttaat 114721 cgaaaagcga aatgaagcgc gccggaatcg cgattttgca ttgtcagacc agatccgcga 114781 ccagctgaaa agcatgaata tcattcttga agatacggct caaggcactc gctggaaacg 114841 gggagaataa cagatgcttg aatttgatac gataaaagat tctaagcagc ttaacggtct 114901 tgcgcttgct tatataggtg atgccatttt tgaagtgtat gtcaggcatc acctgcttaa 114961 gcagggcttt accaaaccaa atgatcttca taagaaatca agccggattg tttcagcaaa 115021 gtcacaggct gagatcctat tttttctgca gaatcaatca ttttttacgg aagaagagga 115081 agcggtgctg aaaagaggca gaaatgccaa gtcagggaca acacctaaaa atacagatgt 115141 tcagacgtac cgctacagta cagcatttga agcgcttctg ggctaccttt ttctagagaa 115201 aaaagaggaa cgacttagtc agctcgtagc cgaagctata caattcggga cgtcagggag 115261 gaaaacaaat gagtcagcaa catgattacg tcatagggaa aaatgcagtg atcgagacgt 115321 taaaatctga tcggaagctg tataagctgt ggatggcgga aaacaccgta aagggacaag 115381 cacagcaagt gattgagctt gccaaaaagc agggaatcac gattcaatac gtcccgagaa 115441 aaaaactcga tcaaatggtg acaggacagc atcagggcgt agtggcacag gttgcagcgt 115501 atgaatatgc agaactggac gatttatata aagcagccga agaaaaaaat gaacagcctt 115561 tcttcctcat tctggacgag cttgaagacc ctcataatct tggttccatt atgaggacag 115621 cagatgcggt cggcgctcat ggcatcgtca ttccaaaacg gagagctgtc gggctgacaa 115681 caacagtggc aaaagcttca acaggagcaa ttgagcacat tcctgtagca agagtcacca 115741 atttggcacg gacgttagaa gagatgaaag agcggggaat ctgggttgtc ggaacggatg 115801 cgtccgcgcg tgaggatttc cgtaatatgg acggcaatat gcctttggct ctagtcatcg 115861 gaagtgaagg aaaagggatg ggccgccttg tgaaggaaaa gtgcgatttt ctcattaaac 115921 tcccgatggc cggaaaggta acttcactaa atgcatctgt cgcggctggt cttttgatgt 115981 atgaagtcta ccggaaacga aaccctgtgg gagaataaag acccatggat atcctgttag 116041 tagacgggta caacatgatt ggagcctggc cgcagctgaa ggatttaaaa gcgaacagtt 116101 ttgaagaggc gagagacgta ctgattcaga aaatggcgga atatcaatcg tatacaggaa 116161 acagggttat tgttgttttt gacgcgcatc tcgtaaaagg gcttgagaaa aaacagacca 116221 accatagagt tgaagtaatt tttacaaaag aaaatgagac ggctgatgag cggatagaaa 116281 agctcgctca ggctttgaat aatattgcga ctcaaattca cgttgcgacc tctgactata 116341 ctgagcagtg ggcgattttc ggacaggggg cattgcggaa atcggcccgg gagcttctga 116401 gagaggtaga aacgattgaa aggcgaatag agagacgggt aagaaaaatc acttccgaaa 116461 agccggcggg taaaattgct ttatcggaag aggttttgaa aacgtttgaa aagtggaggc 116521 ggggagactt agattaagtt gacgcttttt tgcccaatac tgtataatat ttctatctac 116581 gtgcgccggg gggatcggag tgaatctaca gaacaacaag ggaaaattca acaaagagca 116641 gttttgccag ttggaggacg agcaggtcat tgaaaaggtt catgttgggg acagtgatgc 116701 gttagattac ttgattacga agtaccgaaa ctttgttcgg gcaaaagcaa gatcctattt 116761 cttaataggg gcggacagag aggatattgt tcaggaaggc atgataggcc tctataagtc 116821 tattcgtgac ttcaaagagg acaagcttac ctcattcaaa gcttttgcag aattatgtat 116881 tacccgccaa attattaccg caataaagac agctactcgc cagaaacaca ttcctttgaa 116941 ttcctacgcc tcattagata aaccgatctt tgatgaagaa tcagaccgaa cgctgctgga 117001 tgtcatttca ggagcgaaaa ccttaaatcc tgaggaaatg atcattaatc aggaagaatt 117061 tgatgatatt gaaatgaaaa tgggagaact attaagtgat ttagagagaa aagtactcgt 117121 cttatatctc gacgggagaa gttaccaaga gatttctgat gaactgaacc gacatgtgaa 117181 atcgatcgac aatgcccttc agcgtgtgaa acgcaagctg gagaagtact tggaaattcg 117241 cgaaatcagt ttgtaatagg aatttatgct atattgacag tatttttctg actatgatat 117301 gttactaaag ataagaacta atgtctattt agaaaaaggt gtaatgacat gagaaaaaag 117361 attacgttag catgcaagac atgcggaaac cgtaattata cgacaatgaa gagctctgca 117421 tcagcggctg agcgattaga agtaaagaaa tactgcagta cttgcaattc acatacagct 117481 catcttgaaa caaaatagtt tttgcgcttt taaattgtgg aggtctttta catgcgtatt 117541 atgaaattct ttaaagatgt tgggaaagaa atgaaaaagg taagctggcc taaaggaaaa 117601 gagttaacgc gttataccat tacggtaatt tcaacagtta tcttttttgt tatctttttt 117661 gccctccttg acacaggaat ttctcaatta attcgtttaa tagttgaata atgatcagca 117721 atacgtgcta taatagatca taatattact tgccaaaacc cgttcagcgg gttttttatt 117781 gtggcttaaa atgaaagtta tcataggctt gccgcctatt ttttgaagcg ttatggtaat 117841 tcactaaaac caaatgcggg gagggaagga ctggacagtc ctgaatagaa tggaaaagaa 117901 ttggtatgtt gttcacacgt actctggtta tgagaataaa gtaaaagcca acttggaaaa 117961 gcgtgttgaa tcaatgggga tgcaggataa aattttccgt gtagtcgtac ccgaagaaga 118021 agaaacggat atcaaaaacg gcaagaaaaa agtcgtgaaa aagaaagtat tccctggtta 118081 tgtgcttgtt gaaattgtaa tgacagacga ctcttggtat gtcgtccgca acacgccggg 118141 cgttactgga ttcgtaggat ctgccgggtc aggttcaaaa ccgacgccgc ttcttccggg 118201 ggaagcagaa accattctga agagaatggg catggatgaa cgaaaaactg atattgactt 118261 tgaactgaaa gagacagtga aagtaataga cggacctttt gctaacttta caggatcaat 118321 tgaagagatt gattatgata aaagcaaggt caaagttttc gttaatatgt ttggccgtga 118381 aacgccggtt gagctggaat ttacccaaat cgataaattg taatgtgaaa aaacttgaaa 118441 ttgctatata taaatgataa tatagcaaag gtacgtcttg gacttatcca aggcaactag 118501 catgatattt cgtcattcat ataaagaatg aaaccttgag tgggagggtt taccctatta 118561 ccacatcacg gacttaagga ggtgtgtctc gtggctaaaa aagtagttaa agttgtaaaa 118621 ttgcaaattc ctgctggaaa agctaaccca gcaccaccag ttggacctgc acttggtcaa 118681 gccggtgtta acatcatggg attctgtaag gagtttaacg ctcgtacagc tgaccaagct 118741 ggtttaatca ttcctgttga aatttcggtt tacgaagacc gttcatttac atttattaca 118801 aaaactccac ctgctgcagt attgcttaaa aaagcagctg gaattgagtc tggttctggt 118861 gaaccaaacc gtaataaagt ggcaaccgtt aagcgcgata aagtacgcga aatcgctgaa 118921 acgaaaatgc ctgacttaaa cgcagcagac gttgaagcgg caatgcgcat ggttgaaggt 118981 actgcccgca gtatgggtat tgtaatcgag gattaatttg tttcttgtcg ggttgcgagt 119041 tttaacaagt tcgcaaccct tattcgtggg aggttattcc gctataacca cataaggagg 119101 aaattttaaa atggctaaaa aaggtaaaaa gtacgttgaa gctgctaagc ttgtagaccg 119161 ttctaaagct tacgacgtct ctgaagcagt agctctcgtt aaaaaaacaa acacagctaa 119221 attcgacgct acagttgaag tggctttccg tttaggggtt gaccctcgta aaaacgacca 119281 gcaaatccgt ggagcagttg tgcttccaaa cggaactggt aaaactcagc gcgttctcgt 119341 tttcgcaaaa ggcgaaaaag cgaaagaagc tgaagctgct ggtgcagatt tcgtaggcga 119401 tactgactac atcaacaaaa ttcaacaagg ctggttcgat ttcgatgtta tcgtagctac 119461 acctgacatg atgggtgaag ttggtaaaat cggtcgtgta cttggaccaa aaggtttaat 119521 gccgaaccct aaaactggta cagttacttt cgaagttgaa aaagctatcg gcgaaatcaa 119581 agctggtaaa gttgaatacc gcgttgataa agctggaaac attcatgttc ctatcggtaa 119641 agtttctttc gaggatgaaa aacttgttga gaacttcaca acaatgtacg atacaatcct 119701 taaagctaaa cctgctgcag ctaaaggcgt ttacgtgaaa aacgttgctg taacttctac 119761 tatgggacct ggtgtcaaag tagactcttc aacttttaac gtaaaataat attgacatga 119821 catcaacatt ctgatattat tcaaaatgtt gtaaaataga atatcattta taccgtagac 119881 agtaggggcc taaccgctta attatcctac cgaggtgtat attatcacag ctattacgtt 119941 acgtatgctt gtatatacag cctccatgtc tcatggaggc tttttatatg gaatccgtcg 120001 tctcagtcgt gatcacctaa cggtataagt gttacacaag aatctacagg aggtgtaacc 120061 atgagcagcg caattgaaac aaaaaaagtt gttgttgaag aaattgcttc taaactgaaa 120121 gaaagtaaat caacgatcat cgttgactat cgcggactta acgtttctga agtaactgaa 120181 cttcgtaaac agcttcgcga agctaacgtt gagttcaaag tttacaaaaa tacgatgact 120241 cgccgtgcgg ttgaacaagc tgagcttaat ggtttgaatg atttcttaac tggaccgaac 120301 gcgatcgcat tcagcactga agatgttgtc gctccggcta aagttcttaa tgacttcgct 120361 aaaaatcacg aagctcttga aatcaaagct ggcgttatcg aaggtaaagt ttctactgtt 120421 gaagaagtga aagctcttgc tgaacttcca tcacgcgaag gcttgctttc tatgttgctt 120481 agcgtacttc aagctccagt tcgcaacctt gctcttgctg caaaagctgt ggcagaacaa 120541 aaggaagaac aaggcgctta atctaatcag tttttcataa attaaaacaa aatggaggaa 120601 ttacaaatgg ctttaaatat cgaagaaatc attgcttccg ttaaagaagc aactgtactt 120661 gaattgaacg acctagtaaa agcaatcgaa gaagaatttg gcgtaactgc tgctgctcct 120721 gtagctgtag ctggcggagc tgctgctggc ggagctgctg aagagcaaag cgaattcgat 120781 cttatccttg ctggtgcagg atctcaaaaa atcaaagtta tcaaagttgt acgtgaaatc 120841 actggtcttg gcttgaaaga agctaaagag cttgttgaca acactccaaa accacttaaa 120901 gaaggtattg ctaaagaaga agctgaagag cttaaagcta aacttgaaga agttggcgct 120961 tctgtagaag ttaagtaatc ttcacttacc tgtaggggaa gctcgctttt atgaggcgag 121021 ctttttcttt gccattcttt aagccatgaa aaaaggaggt tctaataatg agtgagcact 121081 attattcaga aaaaccttca gtaaaaagca acaagcaaac ctggtctttt aggcttcgga 121141 ataaagattt cacgtttacc agcgacagcg gggttttttc taaaaaagaa gttgatttcg 121201 gctcccgcct gctgattgat tcttttgaag agcctgaggt tgagggcggc attttagatg 121261 taggctgcgg atacggcccg attggtttat cgctcgccag cgactttaaa gaccggacca 121321 tccacatgat tgacgttaat gagagagccg tagaactatc aaatgaaaat gcggaacaga 121381 acggaataac aaacgttaag atttatcaaa gcgatttgtt ttcaaacgtt gattctgctc 121441 aaacatttgc ttctattctt acaaatcccc caatccgagc cggaaaaaaa gttgtccatg 121501 ctatctttga gaaaagcgct gaacacttaa aagcttcagg tgaattgtgg atcgtcatac 121561 agaaaaagca aggcgcgcct tctgccattg aaaagctcga ggaactgttc gatgaagttt 121621 ccgtcgttca aaaaaagaaa ggctattata tcataaaagc aaaaaaagtt tgactcggta 121681 ttttaactat gttaatattg taaaatgcca atgtatatat tttgcttgat atgatgaatt 121741 gtcaatatct atgtataaat tatacaagta tggaaatgct aataaaatcg gtatttgttt 121801 ttggatgtgg ttttcttaat tagaaaccct tttttctttt gtcttgtaaa agtattttct 121861 ttctttggaa gaaatgctta ttacacatat aatacgcatg atttgagggg tgaatcagtt 121921 gacaggtcaa ctagttcagt atggacgaca ccgccagcgc agaagctatg ctcgcattag 121981 cgaagtgtta gaattaccaa atctcattga aattcaaacc tcttcttatc agtggtttct 122041 tgatgagggt cttagagaga tgtttcaaga catatcacca attgaggatt tcactggtaa 122101 cctctctctt gagttcattg attatagttt aggtgagcct aaatatcctg tagaggaatc 122161 aaaagaacgt gatgtgactt actcagctcc gctaagagtg aaggttcgtt taattaacaa 122221 agaaactgga gaggtaaaag accaagatgt cttcatgggt gatttcccta ttatgacaga 122281 tacaggtact tttatcatta acggtgcgga acgtgttatc gtttcccagc ttgttcggtc 122341 tccaagtgta tatttcagtg gtaaagtaga caaaaacggt aaaaaaggtt ttaccgcaac 122401 tgtcattcca aaccgtggcg catggttaga atacgaaact gatgcgaaag atgttgttta 122461 tgtccgcatt gatcgcacac gtaagttgcc ggttacggtt cttttgcgtg ctctcggctt 122521 cggctccgat caagagattc ttgatctcat aggagaaaac gaatacctgc gaaatacgct 122581 tgataaagat aacacagaaa acagcgacaa agcgttgctg gaaatttacg agcgtctccg 122641 tcctggagag ccgcctacag tagaaaatgc gaaaagcttg cttgattctc gtttctttga 122701 tccgaaacga tacgatcttg ccaatgtagg acgctataaa attaataaaa aacttcatat 122761 taagaatcgc ctcttcaatc agagacttgc tgaaacgctt gttgatcctg aaacaggaga 122821 aatccttgct gaaaaaggcc agattcttga tagaagaacg cttgataaag tactgccata 122881 cttagaaaac ggaatcggtt ttagaaagct gtatccgaat ggcggcgttg ttgaagatga 122941 agtgactctt caatcaatta aaatctttgc tccgactgat caagaaggag aacaggttat 123001 caatgtaatc ggcaatgctt acatcgaaga agagattaaa aacatcacgc ctgctgatat 123061 tatttcttca atcagctact tcttcaacct gctgcacgga gtaggcgaca cagatgatat 123121 cgatcatctt ggaaaccgcc gtttacgttc tgtaggcgag cttctccaga accaattccg 123181 tatcggttta agccgtatgg agcgtgtggt tcgtgagaga atgtcaattc aagatacgaa 123241 tacaattacg cctcagcagc tgatcaatat tcgtcctgtt attgcgtcca ttaaagagtt 123301 ctttggaagc tcacagcttt ctcaattcat ggatcagacg aacccgcttg ctgaattaac 123361 gcacaagcgt cgtctgtcag cattaggacc gggcggattg acacgtgagc gtgccggaat 123421 ggaagtgcgt gacgttcact actcccacta tggccgtatg tgtccgattg aaacgcctga 123481 gggcccgaac atcggtttga tcaactcact atcatcttat gcaaaagtaa accgttttgg 123541 ctttattgaa acgccatatc gccgcgttga ccctgaaaca gggaaggtaa cgggcagaat 123601 cgattactta actgctgatg aagaggataa ctatgttgtc gctcaagcga atgctcgtct 123661 tgatgacgaa ggcgccttta ttgatgacag catcgtagct cgtttccgcg gggagaacac 123721 cgttgtttcc agaaatcgtg tagactacat ggatgtatcg cctaagcagg ttgtatctgc 123781 tgcgacagca tgtatcccgt tcttagaaaa cgatgactcc aaccgtgccc tcatgggagc 123841 gaacatgcag cgtcaggctg tgcctttgat gcagccggaa gcgccatttg ttggaactgg 123901 tatggaatac gtatcaggaa aagactctgg tgccgctgtt atttgtaaac accctggtat 123961 cgttgaacgc gtagaagcca aaaacgtttg ggttcgccgt tatgaagaag tagacggtca 124021 aaaagtaaaa ggaaacctgg ataaatacag cctgctgaaa tttgtccgct ctaaccaagg 124081 tacgtgctac aaccagcgtc cgatcgtaag tgtcggcgat gaagtggtaa aaggagaaat 124141 ccttgctgac ggtccttcta tggagcttgg tgaacttgca cttggccgta acgtaatggt 124201 cggcttcatg acgtgggatg gctacaacta tgaggatgcc atcatcatga gtgaacgcct 124261 agtgaaggat gatgtttata catctatcca cattgaagaa tacgaatcag aagcacgtga 124321 tacgaaactt ggacctgaag aaatcactcg cgatattcca aacgtcggtg aagatgcgct 124381 tcgcaatctt gatgaccgcg gaatcatccg tattggggca gaagtaaaag acggagatct 124441 tcttgttggt aaagtaacgc ctaaaggcgt aactgaactg actgccgaag aacgccttct 124501 tcacgccatc tttggcgaga aagcccgcga ggttcgtgat acttctcttc gtgtgcctca 124561 tggcggcggc ggaattatcc atgacgttaa agtcttcaac cgtgaagacg gagacgaact 124621 tcctccaggt gttaaccagt tagtacgcgt atatatcgtt cagaaacgta agatttctga 124681 aggggataaa atggccggtc gtcacggtaa caaaggtgtt atctctaaga ttcttcctga 124741 agaggatatg ccttaccttc ctgacggcac accaattgat atcatgctta acccgctggg 124801 cgtaccatca cgtatgaaca tcgggcaggt attggaactt cacatgggta tggccgctcg 124861 ttaccttggc attcacattg catctcctgt atttgacgga gcgcgagaag aggatgtctg 124921 ggaaacactt gaagaagccg gcatgtctcg tgacgccaaa acagtgcttt acgacggacg 124981 tactggagag ccgtttgata accgtgtatc tgtcggtatc atgtacatga tcaaactggc 125041 tcacatggtt gacgataaac ttcatgcacg ctctacaggc ccttactcac ttgttacgca 125101 gcagcctctt ggcggtaaag cgcaatttgg cggacagcgt tttggtgaga tggaggtttg 125161 ggcacttgaa gcttacggtg cggcttacac tcttcaagaa attctgactg ttaagtctga 125221 tgacgtggtt ggacgtgtga aaacatacga agccatcgtt aaaggcgaca atgttcctga 125281 accaggtgtt ccggaatcat tcaaagtatt aatcaaagaa cttcaaagct taggtatgga 125341 tgtcaaaatc ctttctggtg atgaagaaga aatagaaatg agagatttag aagacgaaga 125401 agatgcgaaa caagctgacg gcctggcatt atcaggtgat gaagagccgg aagaaacagc 125461 atctgcagac gttgaacgcg atgtagtaac aaaagaataa tctctagtta taaaggcaag 125521 tgacatcggt taatccgaag ataaaaaggg aggtaggccc cttgctagat gtgaacaatt 125581 ttgagtatat gaacatcggt cttgcttcac cagataaaat ccgttcatgg tcttttggtg 125641 aagtgaaaaa gcctgaaacg ataaactatc gtacgttaaa acctgaaaag gacggtctat 125701 tctgcgaacg cattttcgga ccgactaagg actgggaatg tcattgcggg aagtacaagc 125761 gagttcgtta taaaggcgta gtttgtgacc gctgcggagt cgaagtaaca cgggctaaag 125821 tccgtcgtga gagaatgggg cacattgaac tggctgcccc agtttcccac atttggtatt 125881 tcaaaggtat tccaagccgt atgggtcttg tgctggatat gtcacctcgt gctttagaag 125941 aagtcattta ctttgcttct tacgttgtaa ctgatccggc gaatacaccg cttgaaaaga 126001 aacagcttct gtctgagaaa gaataccgtg cttatcttga taaatacggt aataaattcc 126061 aagcatctat gggtgctgaa gcaattcata aacttcttca agatatcgat cttgtaaaag 126121 aagttgatat gttaaaagaa gagctgaaaa cttcacaagg acaacgccgt actcgtgcga 126181 tcaaacgtct tgaagtttta gaagccttcc gtaactcagg aaacaagcct tcttggatga 126241 tccttgatgt gcttcctgtt attcctccgg agcttagacc gatggttcag ctagatggcg 126301 gacgttttgc gacttctgat ttgaatgacc tttatcgtcg tgtcatcaac cgtaacaatc 126361 gtttgaaacg ccttttggac cttggtgcgc ctagcatcat cgttcaaaac gaaaagcgta 126421 tgcttcaaga ggctgtcgat gccctaattg acaacggccg ccgcggacgc cctgtaacag 126481 gtcctggaaa cagaccgtta aaatctcttt ctcacatgct gaaagggaag caaggccgtt 126541 tccgtcaaaa ccttcttggt aaacgtgtcg attactccgg acgttctgta atcgttgttg 126601 gtcctcattt gaaaatgtac caatgcggat taccgaagga aatggcactt gaacttttca 126661 aacctttcgt tatgaaagaa cttgttgaaa aaggtcttgc tcacaacatt aagagtgcga 126721 aacgcaaaat tgagcgcgta cagcctgaag tttgggatgt actagaatca gttattaagg 126781 agcatccggt actgctgaac cgtgccccta cacttcacag attaggtatc caggcgtttg 126841 aaccaacgct tgttgaagga cgcgcaatcc gtcttcaccc gctcgtatgt acagcttaca 126901 acgctgactt tgacggtgac caaatggcgg ttcacgtacc attatctgct gaagcacaag 126961 ctgaagcacg catcttgatg cttgctgctc aaaacatctt gaaccctaaa gatggtaaac 127021 cggttgtaac accgtctcag gatatggtac taggtaacta ttacctgaca cttgagcgtg 127081 ccggtgctgt cggtgaaggt atggtcttca agaatacaga cgaagcgctt cttgcttatc 127141 aaaacggata tgttcacctt catacgagag tagctgttgc agctaactca cttaagaatg 127201 tgacatttac cgaagaacag cgctcaaaat tgttaattac aactgtcggt aagcttgtct 127261 tcaatgaaat tcttccggaa tcattccctt acatgaatga accaacgaag agcaacattg 127321 aagagaaaac acctgaccgt ttcttcttag aaaaaggtgc tgatgttaaa gctgttatcg 127381 cacagcagcc aatcaatgcg ccgtttaaaa aaggcattct gggtaaaatc atcgcggaaa 127441 tctttaaacg attccatatt acggaaacgt ctaaaatgct tgaccgcatg aaaaacctag 127501 gtttcaaata ttcaactaaa gctggtatta cagttggggt ttctgacatc gtcgtactcg 127561 atgataaaca agaaattctt gaggaagcgc aaagcaaagt tgacaacgtt atgaagcaat 127621 tccgccgcgg tcttatcact gaagaagaac gctatgagag agtcatctct atctggagtg 127681 ctgcaaaaga cgttatccaa ggcaaactga tgaaatcact tgatgaactc aacccgatct 127741 acatgatgag tgactctggt gcccgtggta acgcatctaa ctttacgcag cttgccggaa 127801 tgcgcggcct gatggccaac ccggctggac gtatcattga gttgccgatc aaatcaagtt 127861 tccgtgaagg tctgacagta ttggagtact ttatctccac acacggtgcg cgtaaaggtc 127921 ttgccgatac cgctcttaaa actgctgact caggttacct tacacgccgt ctcgttgacg 127981 ttgctcagga tgttatcatc cgtgaaactg attgcggaac tgaccgaggc attcttgcta 128041 agcctcttaa agaaggaact gaaacaattg agcgcttaga agaacgctta atcggacgtt 128101 ttgcaagaaa acaagtgaag caccctgaaa caggtgaagt gcttgtgaat gaaaacgaac 128161 tgatcgatga agataaagca ctggagattg tcgaagccgg cattgaagaa gtgtggatcc 128221 gttctgcctt cacatgtaat acgcctcatg gtgtatgtaa acgatgctat ggccgaaatc 128281 ttgcaactgg ctccgatgtt gaagtcggtg aagctgtcgg aatcattgct gcccaatcaa 128341 tcggtgagcc tggtacacag ttaacaatgc gtacattcca tacaggcggg gttgccggag 128401 acgatatcac acagggtctt ccgcgtatcc aagagctttt cgaagcgcgt aatccgaaag 128461 gtcaggcaac aattacagaa atcgacggta cagtcgttga gatcaatgaa gttcgtgata 128521 agcaacagga aattgtggtt caaggcgcag tggaaacacg ttcttatacg gcaccttaca 128581 actcccgcct gaaagtagcg gaaggagata aaattactcg aggccaagta ctgacagaag 128641 gttcaatcga tccgaaagaa cttcttaaag tgactgacct gacgactgtt caagagtatc 128701 ttctccatga ggttcaaaag gtttaccgta tgcagggtgt tgaaatcggt gataaacacg 128761 tagaagtaat ggttcgccag atgcttcgca aagtacgcgt gattgatgcc ggtgacactg 128821 atgtgcttcc aggtacattg cttgatattc accaatttac tgaagcgaac aaaaaggtat 128881 tgcttgaagg caaccgacca gctacaggcc gtcctgtctt actcggtatt acaaaagcat 128941 ctcttgaaac tgattcattc ttatctgctg cttccttcca ggaaacaaca cgtgtcctta 129001 cagatgcagc gatcaaaggt aagcgtgacg agcttctcgg cttgaaagag aatgttatca 129061 tcggtaagct tgttccagca ggtacaggaa tgatgaaata ccgtaaagta aaaccagtat 129121 caaatgttca gccgactgac gatatggtcc cggttgaata actgatttaa ctctgctgaa 129181 agactgcaaa aacagtcttt cagcagatat atttatgaaa aagtcactct atgagaagaa 129241 cgaatctaaa aaatgtcata ccttgttgac attcgtctcc tagaatgata atataaccaa 129301 ggtgctcgaa ataaacctgt tactttggag gatatgttta tgtcttatga taaagtatca 129361 caggccaaat caattattat tggtacgaag caaacagtga aagctctaaa gcgaggttca 129421 gtaaaggaag tagtcgttgc aaaagacgca gatccgatac tcacgtcaag tgttgtttca 129481 cttgctgaag atcaaggtat ctctgtctca atggttgaat ccatgaaaaa gctcggcaaa 129541 gcctgcggaa ttgaggtagg agcagccgct gttgccatta ttttataacg tacttttgtt 129601 tttgcgtaag attccatctt gtgtaaagac attgtttttt gccttttgat gaaccacctg 129661 ggtatgtggg ttataaaacg taatgaaggg aggaaaaatt catgcctaca attaatcagc 129721 taattcgcaa aggacgcgtg agtaaagtag aaaactcaaa gtctcctgca cttaacaaag 129781 gatacaacag ctttaaaaaa gagcacacta acgtatcttc tccacaaaaa cgcggggtat 129841 gtactcgtgt tggtacaatg acaccgaaaa aaccgaactc agcacttcgt aaatatgctc 129901 gtgttcgttt gactaacgga atcgaggtta ctgcttacat tcctggtatc ggtcacaacc 129961 tgcaagagca cagtgttgta cttatccgcg gcggacgtgt aaaagactta ccaggggtac 130021 gttaccacat cgttcgtggt gcgcttgata ctgctggagt tgaaaaccgt gcacaaggcc 130081 gttctaaata cggtacgaaa aaacctaaag caaaataata tacgaaaata cgcataattg 130141 atgaagggag gatattcaga tgccacgtaa aggtcctgta gcaaaaagag atgttttacc 130201 tgatccgatt tacaactcta agcttgtatc tcgtttaatc aacaaaatga tgatcgatgg 130261 taaaaaaggt aagtctcaaa cgatcctata caagtcattc gatatcatta aagaacgtac 130321 tggcaatgat gcaatggagg ttttcgaaca agcattgaaa aacatcatgc ctgtacttga 130381 agtaaaagca cgccgtgtag gtggtgcgaa ctaccaagtt cctgtagaag ttcgtcctga 130441 acgtcgtacg actcttggac ttcgctggtt agttaactac gctcgtcttc gtggagaaaa 130501 aacgatggaa gagcgtttag ctaacgaaat ccttgacgca gctaacaaca ctggtgctgc 130561 tgttaagaaa cgtgaagaca ctcataagat ggctgaagca aacaaagcat ttgctcacta 130621 tcgctggtag gatttataga ttaacaaaac acaatttcct aataaggaag gagaaattac 130681 ccaatggcaa gagagttctc cttagaaaaa actcgtaata tcggtatcat ggctcacatc 130741 gatgccggta aaacgactac tacagaacgt atcttgttct atactggtcg tatccacaaa 130801 attggtgaaa ctcatgaagg agcttcacaa atggactgga tggagcagga acaagaacgt 130861 ggtatcacaa tcacttccgc tgcgactact gcacagtgga aaggataccg cgtaaacatc 130921 atcgatactc caggacacgt agacttcaca gttgaagttg aacgttctct tcgtgtactt 130981 gatggtgctg ttgctgtact tgacgcgcaa tcaggcgttg agcctcaaac agaaactgtt 131041 tggcgtcagg caacaactta tggagtaccg cgtatcgttt ttgttaacaa aatggacaaa 131101 atcggtgcag acttccttta ctctgtagga actttaagag accgtcttca agcaaacgct 131161 catgcaattc aattgccgat cggtgctgaa gataacttcg aaggtatcat tgaccttgta 131221 gaaaacgttg cgtatttcta cgaagatgac ctcggaactc gttctgatgc aaaagaaatc 131281 cctgaagagt acaaagagca agctgaagag cttcgcaaca gccttattga agctgtatgt 131341 gagcttgatg aagagcttat ggataagtac cttgagggtg aagaaatcac aattgacgag 131401 ttaaaagcag gaattcgtaa aggtacatta aatgttgaat tctaccctgt tcttgttggt 131461 tctgccttca aaaacaaagg tgttcaacta gtacttgatg ctgttcttga ctaccttcct 131521 gcaccaactg acgttgctgc aatcaaaggt acacgtcctg atacaaatga agagattgag 131581 cgtcattctt ctgacgaaga gccattctct gcattagcat ttaaagttat gactgaccct 131641 tacgttggta agttgacgtt cttccgtgtg tactctggaa cacttgattc tggttcatac 131701 gtgaaaaact ctactaaagg caaacgtgag cgtgttggac gtattcttca aatgcacgct 131761 aacagccgtg aagaaatctc tactgtatac gcaggggata tcgcagctgc tgtaggtcta 131821 aaagatacaa ctactggaga tactctatgt gatgagaagg atcttgttat ccttgagtca 131881 atggaattcc cagaaccagt tatcgacgtt gctattgagc ctaaatcaaa agctgaccaa 131941 gataaaatgg gtatcgcttt agcgaaactt gctgaagaag atcctacatt ccgtactcaa 132001 acaaacccag aaactggcca aacgatcatc tctggtatgg gtgaacttca ccttgatatc 132061 attgttgacc gtatgaaacg cgaatttaaa gtagaagcca atgttggtgc tcctcaagtt 132121 gcgtaccgtg aaacattccg taccggtgca aaagttgaag gtaaattcgt acgtcagtct 132181 ggtggacgcg gtcagttcgg acacgtttgg atcgaattcg aaccaaacga agaaggcgct 132241 ggctttgaat ttgaaaatgc gattgtcggt ggggtcgttc ctcgtgaata catcccagct 132301 gttcaagcag gtctggaaga tgcactcgaa aatggtgtac tagcaggctt cccgcttatc 132361 gacattaaag ctaaactttt cgacggttct taccatgatg ttgactcaaa cgaaatggca 132421 tttaaagtcg ctgcttctat ggcattgaaa aatgcagtca gcaaatgtaa cccagttctt 132481 cttgaaccaa tcatgaaagt ggaagtggtt attccagaag aatatatggg agatatcatg 132541 ggtgatatca cttcacgtcg cggacgcgta gaaggtatgg aagcacgcgg taacgctcaa 132601 gttgttcgtg ctatggttcc tcttgctgaa atgttcggtt acgctactgc acttcgttct 132661 aatacgcaag gtcgcggtac gttcactatg cacatggatc actacgaaga agtgccgaag 132721 agcgtcgcag aagaaattat caaaaaaaat aaaggcgaat aattgatttt gccgcttaac 132781 tcaagtataa ctactattgt aagatgagga agtgaaagct ttctttcact tcctatcact 132841 ctatacatta ctaattaaaa gctcttaagg aggattttag aatggctaaa gaaaaattcg 132901 accgttccaa atcacatgcc aatattggta caattggaca cgttgaccat ggtaaaacaa 132961 ctttaactgc tgctatcaca acagtacttc ataagaaatc tggtaaaggt acagctatgg 133021 cgtacgatca aattgatggt gctccagaag aacgcgagcg cggtatcaca atctctactg 133081 cacacgttga gtacgaaact gaaactcgtc actatgcaca cgttgactgc ccaggacacg 133141 ctgactatgt taaaaacatg atcactggtg ctgcgcaaat ggacggagct atccttgtag 133201 tatctgctgc tgatggccca atgccacaaa ctcgtgagca catccttctt tctaaaaacg 133261 ttggtgtacc atacatcgtt gtattcttaa acaaatgcga catggtagac gacgaagagc 133321 ttcttgaact agttgaaatg gaagttcgcg atcttcttag cgaatacgac ttccctggtg 133381 atgatgtacc agttgttaaa ggttctgctc ttaaagctct tgaaggagac gctgagtggg 133441 aagctaaaat cttcgaactt atggatgcgg ttgatgagta catcccaact ccagaacgcg 133501 acactgaaaa accattcatg atgccagttg aggacgtatt ctcaatcact ggtcgtggta 133561 cagttgctac tggccgtgta gaacgcggac aagttaaagt cggtgacgaa gttgaaatca 133621 tcggtcttca agaagagaac aagaaaacaa ctgttacagg tgttgaaatg ttccgtaagc 133681 ttcttgatta cgctgaagct ggtgacaaca ttggtgccct tcttcgcggt gtatctcgtg 133741 aagaaatcca acgtggtcaa gtacttgcta aaccaggtac aatcactcca cacagcaaat 133801 tcaaagctga agtttacgtt ctttctaaag aagagggtgg acgtcatact ccattcttct 133861 ctaactaccg tcctcagttc tacttccgta caactgacgt aactggtatc atccatcttc 133921 cagaaggcgt agaaatggtt atgcctggag ataacactga aatgaacgtt gaacttattt 133981 ctacaatcgc tatcgaagaa ggaactcgtt tctctattcg tgaaggcgga cgtactgttg 134041 gttcaggcgt tgtttctaca atcactgagt aatagtatgg ttttaaacga gacccctgtg 134101 ggtctcgttt tttgtttgct tatctttttc ttgtataata ggatctatca tattcgaggg 134161 gttaatattt atgattcctg aaaagaaatc aatcgcaatc atgaaagaac taagcattgg 134221 aaatacaaag caaatgctga tgattaatgg agttgacgtg aaaaatccat tgctgctttt 134281 tttacatggc gggccgggaa cgccgcaaat cggatatgtt agacattatc aaaaagagct 134341 ggaacagtat tttacagtag ttcattggga tcagagagga tcggggcttt cttattctaa 134401 gcgaatttcg catcactcta tgacaataaa tcacttcatt aaagatacaa tccaagtcac 134461 tcaatggctt ttagctcatt tttcaaaatc aaaactttac ctagccggtc attcttgggg 134521 atcaatactg gcgcttcatg tgctgcagca gcgtcctgat ttattttaca cgtattatgg 134581 aatcagccag gttgttaacc cgcaagatga agaatcaact gcttatcaac atattcgtga 134641 aatttccgaa tcaaaaaaag ccagcatatt atctttcctt acacgtttca ttggtgctcc 134701 gccttggaag caggatatcc agcaccttat ctatcggttt tgtgttgagc taaccagggg 134761 aggattcact caccgtcatc gtcaatctct cgctgtatta tttcaaatgc ttactggcaa 134821 tgagtatgga gtgcggaaca tgcacagctt ccttaatgga ttgcgcttca gtaaaaaaca 134881 tttaactgat gagttgtacc ggtttaatgc ttttacatca gttccttcta ttaaagtacc 134941 gtgtgttttc atttcaggga aacatgactt aattgttcct gcagaaatat cgaaacagta 135001 ttatcaagaa cttgaggcac ctgaaaagcg ctggtttcaa tttgagaatt cagctcacac 135061 cccgcatatt gaggagccat cattattcgc gaacacatta agtcggcatg cacgacacca 135121 tttatgatag atccttgata aataagaaaa acccctgtat aataaaaaaa gtgtgcaaat 135181 catgcatatt ttaaataagt cttgcaacat gcgcctattt tctgtataat ggtgtatgtt 135241 ggtctttgac tgcgatgaag tgagaggttg ctgacacacc cggccgcttt gccatggcaa 135301 ggtgttcagg tttttctcac ggagaactgt ctaacgtgat gtaggcgaaa aggagggaaa 135361 ataatggcaa aacaaaaaat tcgtattcgt ttgaaagcat atgatcatag aatccttgat 135421 caatctgcag agaagattgt tgaaacggca aaacgttctg gtgccagcgt atctggtccg 135481 attccgttgc caactgaaaa atcagtttac acaatccttc gtgcggtgca caaatacaaa 135541 gattctcgtg agcaatttga aatgcgtaca cataaacgtt taatcgacat tgtgaaccca 135601 acaccacaaa ctgttgatgc tcttatgcga ttagacttac catctggtgt cgatatcgaa 135661 attaaacttt aattctaaaa tatagaatga tcttaatagg aggtgtgacg aatgaccaaa 135721 ggaatcttag gaagaaaaat tggtatgacg caagtattcg ctgagaatgg tgatcttatt 135781 ccggtaactg ttatcgaggc tgctccaaac gttgttcttc aaaagaaaac agctgaaaac 135841 gacggttacg aagcaatcca gcttggtttt gacgacaagc gtgaaaagct ttctaacaaa 135901 cctgaaaaag ggcacgttgc aaaagcggaa actgctccta agcgcttcgt taaagaatta 135961 cgcggagtgg aaatggatgc gtatgaagtt ggtcaggaag tcaaggttga aattttctct 136021 gctggagaaa tcgtagatgt aacaggagta tctaaaggta aaggtttcca aggtgcgatc 136081 aagcgccacg gacaatctcg cggacctatg tctcacggtt cacgctacca ccgtcgtcct 136141 ggttcaatgg gacctgtaga tcctaaccgt gtattcaaag gtaaattatt acctggacgt 136201 atgggcggag agcaaatcac tgttcaaaac cttgaaatcg taaaagttga tgcagaacgc 136261 aatcttcttt tgatcaaagg taacgtacct ggtgcgaaga aatctttaat cactgttaaa 136321 agtgctgtta aatctaaata attctcttag gaaaggagga aattgattat gccaaaagta 136381 gcattataca accaaaacgg ttctactgct ggtgacatcg aattaaacgc ttctgtattt 136441 ggtatcgaac caaatgagag tgttgtattc gacgctattc ttatgcaaag agcttcctta 136501 cgtcaaggaa ctcacaaagt aaaaaatcgt tctgaagtac gcggcggagg tcgtaaacca 136561 tggcgtcaaa aaggtactgg acgtgcccgt caaggttcaa tccgttcacc gcaatggcgc 136621 ggaggtggtg tcgtattcgg cccaacacca cgcagctatt cttataaatt acctaaaaaa 136681 gttcgccgct tggcaatcaa atcagtattg tcttctaaag tgatcgacaa caacatcatc 136741 gttcttgaag atcttactct tgatacggct aaaacaaaag aaatggcagc tatccttaaa 136801 ggattatctg ttgagaaaaa agctttaatc gtaactgcgg atgcaaacga agcagtagca 136861 ttatctgctc gtaacattcc tggagttact gttgttgaag ctaacggaat caacgtttta 136921 gacgttgtca accacgagaa gcttctgatt acaaaagcag cggttgaaaa agtagaggag 136981 gtgcttgcat aatgaaagat cctcgtgatg ttctaaagcg ccccgtcatt actgaacgtt 137041 ctgccgattt aatgactgaa aaaaaatata cttttgaagt tgatgtaaga gctaacaaaa 137101 cagaagtgaa agacgcggtt gaaagcatct ttggagtgaa agttgacaaa gtcaacatca 137161 tgaactacaa aggcaaatca aaacgtgttg gacgctacac tggtatgact agccgtcgca 137221 gaaaagcgat cgtaaaactt actgcagaca gcaaagaaat cgaaattttt gaagcttaat 137281 tatctgtaaa aagaaggagg gaaattcaaa atggcgatta aaaagtataa accgacctct 137341 aatggacgtc gtggcatgac aacttcagat tttgctgaaa tcacgactga caagccggaa 137401 aaatccttgc ttgctcccct tcacaaaaaa ggcggacgta acaaccaagg taaattgact 137461 gtacgtcacc aaggtggcgg acataaacgc caataccgtg ttatcgactt caaacgcgat 137521 aaagatggta tacctggacg cgttgctaca gttgaatacg atccaaaccg ttcagctaac 137581 atcgctctaa tcaactatgc agacggagaa aaacgttaca ttcttgctcc taaaggaatt 137641 caagtaggta ctgaaatcat gtcaggtcct gaagctgaca ttaaagtagg taatgcactt 137701 ccacttatca acatccctgt tggtacagtt gtgcataaca ttgaattaaa acctggtaaa 137761 ggcggacagc ttgtacgttc agctggtaca tctgctcagg ttcttggtaa agaaggtaaa 137821 tacgttcttg tacgtcttaa ctctggtgaa gttcgcatga tcctttctgc ttgccgtgct 137881 tctatcggtc aagtaggtaa cgaacagcac gaacttatca acattggtaa agctggacgt 137941 tctcgctgga aaggcatccg tcctacagtt cgtggttctg taatgaaccc taacgatcac 138001 ccacacggtg gtggtgaagg acgtgcgcca atcggacgta aatcaccaat gtctccatgg 138061 ggcaaaccaa ctcttggatt caagactcgt aagaaaaaga acaaatccga taaatttatc 138121 gtacgtcgtc gtaaaaataa ataacggggt tgtctacggt tcttttcgga ccgtagtgca 138181 atcacgaagg gaggttccaa aatggctcgc agcttaaaaa aaggaccatt tgtcgatgga 138241 cacttgatga ctaaaatcga gaaattaaat gaaacagaca agaaacaagt cgtaaaaact 138301 tggtctcgtc gttctactat tttcccacag tttattggtc acacaatcgc agtctatgac 138361 ggacgtaaac acgtgcctgt attcatctct gaagatatgg tagggcacaa gttgggtgaa 138421 ttcgctccaa ctcgtacgta caaaggtcat gctagtgatg acaaaaaaac aagacgctaa 138481 gagaggaggc ttttaaatgc aagctaaagc tgttgcaaga acagtccgta ttgctcctcg 138541 taaagcacgt ctagtaatgg acctgattcg aggcaagcaa gtaggtgagg cagtatcaat 138601 cttgaacctt acaccaagag ctgcttctcc aattatcgag aaagtattaa aatccgctat 138661 tgcaaatgct gagcataact atgaaatgga cgctaacaac ctggttattt ctcaagcatt 138721 cgttgacgaa ggccctacgt taaaaagatt ccgcccacgt gctatgggac gtgcgagcca 138781 aatcaacaaa cgtacgagcc acattacaat cgttgtatca gaaaagaagg agggataagt 138841 agtgggtcaa aaggtaaatc cagtcggtct tcgtatcgga gtcattcgtg attgggaatc 138901 taagtggtac gctggtaaag attacgctga cttcctgcac gaagatttaa aaattcgtga 138961 atacattagc aaacgccttt ctgacgcttc tgtttctaaa gtagaaattg agcgtgcagc 139021 aaaccgcgtt aacattacga tccacacagc taagcctggt atggttatcg gtaaaggcgg 139081 ttctgaagtc gaagcacttc gcaaagccct taacagcctt actggcaagc gtgtacacat 139141 taacattctt gaaatcaaaa gagcagatct tgatgcacag ctagttgctg acaacatcgc 139201 tcgtcaatta gaaaaccgtg tttctttccg ccgtgcgcag aaacaacaaa tccaacgtac 139261 tatgcgtgct ggagcacaag gtgtgaaaac aatggtttct ggtcgtcttg gcggtgcaga 139321 tatcgctcgt tctgaatact acagtgaagg aactgttcca ttgcacacat tacgtgcgga 139381 cattgactat gcaacatctg aagctgatac tacttacggt aagcttggtg taaaagtctg 139441 gatctatcgt ggagaggttc ttcctactaa gaagaaaaat gaggaaggag gaaaataata 139501 tgttattacc aaaacgcgtt aaatatcgca gagagcatcg cggaaaaatg cgtggccgtg 139561 cgaaaggcgg tactgaagta catttcggag aattcggtat ccaagctcta gaagcttctt 139621 ggattactaa ccgtcaaatc gaagctgcac gtattgcgat gactcgttac atgaaacgtg 139681 gcggtaaagt ttggatcaaa attttccctt ctaaacctta cactgctaaa ccacttgagg 139741 tacgtatggg atccggtaaa ggggctccag aaggttgggt agctgttgta aaaccgggca 139801 aagttttatt tgaaatttct ggtgtgtctg aagaggttgc tcgtgaagcg cttcgccttg 139861 catctcacaa attgccaatt aaaacgaagt tcgtaaaacg tgaagaaatt ggtggtgaat 139921 caaatgaaag ctaatgaaat tcgtgacctt accactgctg aaattgaaca aaaagtaaag 139981 tctcttaaag aagaactttt caatcttcgc tttcaattag cgacaggaca acttgaaaat 140041 actgctcgca ttcgtgaagt gcgcaaagct atcgcgcgca tgaaaactgt gattcgtgaa 140101 agagaaattg ctgctaataa ataatcactg aggggaggtc gtgagcatga gcgaacgtaa 140161 ccaacgcaaa gtttaccaag gccgtgttgt ttctgacaaa atggataaaa ccattactgt 140221 tgttgttgag acatacaaaa aacatacact ttacggtaaa cgcgtaaaat actcaaaaaa 140281 attcaaagca catgatgaaa ataatcaagc taaaatcggt gacatcgtta agatcatgga 140341 aactcgtcca ttgtctgcaa ctaagcgttt ccgtctagtt gaagttgtcg aagaagctgt 140401 tattatctaa taaagttcgg aattcttttt ccgaagggag gtaacaaata atgattcaac 140461 aagagactcg tttaaaagta gctgacaact ctggcgcacg tgaagtactt actattaaag 140521 ttcttggtgg ttctggacgt aaaacagcta acattggtga tgtaattgtt tgcacggtta 140581 aacaagcaac accaggaggc gttgtcaaaa aaggtgaagt cgtaaaagct gttatcgttc 140641 gcactaaaag cggagcgcgc agaagtgacg gttcatacat cagcttcgat gagaatgcat 140701 gtgttatcat ccgtgacgac aagagcccac gcggaactcg tatcttcgga ccagttgctc 140761 gtgaattgcg tgaaaacaac tttatgaaaa ttgtttctct agctccagaa gttatctaat 140821 tgaaataaat gccttactca aggaggtgcg atcaggatgc atgtaaaaaa aggcgataaa 140881 gttatggtta tctctggtaa agataaaggc aaacaaggaa caatccttgc tgctttccct 140941 aaaaaggacc gcgttttagt tgaaggtgtt aacatggtaa agaaacactc taaaccaact 141001 caagctaacc ctcaaggcgg tatttctaat caagaggcgc caattcatgt atcaaacgtt 141061 atgccgctcg atcctaaaac aggtgaagtg actcgcgtag gatacaaagt ggaagatggc 141121 aaaaaagttc gtgtagcaaa aaaatctggg caagttctag ataaatagta ttaaaaggaa 141181 gggaggtcta tctcatgaac cgccttaaag aaaagtacaa taaagaaatt gcacctgctt 141241 taatgactaa gttcaactat gattcagtca tgcaagtgcc taaaatcgaa aaaatcgtaa 141301 tcaacatggg tgttggtgac gctgttcaaa acgccaaagc aatcgacagt gctgttgagg 141361 aattaacgtt tatcgcaggt caaaaacctg tcgttactcg tgcgaagaaa tcaattgctg 141421 gattccgtct tcgtgaggga atgcctatcg gtgcgaaagt aactcttcgc ggagagcgca 141481 tgtatgattt ccttgataaa cttatttctg tatctttacc gcgtgtacgt gacttccgcg 141541 gggtttctaa aaaatctttc gacggtcgcg gtaactacac acttggtatc aaagaacagt 141601 taatcttccc tgaaattgac tacgataaag taacaaaggt tcgcggaatg gacatcgtta 141661 tcgtaacaac tgctaatact gacgaagaag ctcgtgagct attaactcaa gtaggtatgc 141721 cgttccagaa ataatcaatg aaagggaggc gaaatcgtgg ctaaaaagtc tatgattgcg 141781 aaacaacaac gtacaccaaa gtttaaagta caagagtaca cacgctgtga acgctgcgga 141841 cgtccgcatt cagtcattcg taaatttaaa ctttgccgta tttgtttccg tgagcttgca 141901 tataaaggac aaattcctgg cgtgaaaaaa gccagctggt aatccccaag aaagggaagg 141961 aggtaattat ataatggtta tgacagatcc aattgcagat atgctaactc gtattcgcaa 142021 tgcaaacatg gtacgtcatg agaagcttga aattcctgct tctaaattga aaagagaaat 142081 tgctgaaatt ttaaagcgtg aaggtttcat tcgtgacgtt gagttcgtag aagacagcaa 142141 acaaggtatt atccgcgttt tcttgaaata cggacaaaac aacgagcgcg ttatcactgg 142201 tcttaaaaga atcagcaagc ctggtttgcg tgtttatgct aaatctaatg aagtaccccg 142261 cgtacttaac ggtcttggaa tcgcgattat ttctacatca caaggtgttt taacggacaa 142321 agaagcccgt gcaaaacaag ctggtggaga agttctagca tacgtttggt aagaagttta 142381 acatgaatgg aggtgtttgg tatgtctcgt gtaggtaaga agctacttga gattccttct 142441 gatgttacag taacgttaaa tgataacaac actgtagctg tgaaaggacc aaaaggagaa 142501 ttaactcgta cgtttcaccc tgatatggag attaaagtag aggacaatgt gcttacagtc 142561 gctcgtcctt ctgatcaaaa agagcaccgt gccctgcatg gtacgactcg cagtctgctt 142621 ggcaacatgg ttgaaggtgt atctaaagga tttgaaagag gtttggaatt agtcggtgtc 142681 ggttaccgtg cttctaaatc cggaaataaa cttgttttaa acgttggata ctctcatcct 142741 gttgagatcg ttcctgaaga aggcatcgaa atcgaagttc cttctcaaac aaaagtagtt 142801 gtaaaaggta cagacaaaga acgcgtagga gctattgctg ctaacatccg cgctgtacgt 142861 tctccagagc cttacaaagg taaaggaatc cgctacgaag gtgaagttgt tcgccgtaaa 142921 gaaggtaaat ctgctaagta agatcgctta aagtgaagaa aggagtgacc tagatgatta 142981 cgaaaactag caaaaatgct gctcgtctta aaagacacgc tcgtgttcgc gctaaacttt 143041 ccggtactgc tgaaagaccg cgcctgaacg ttttccgttc taacaagcac atttacgctc 143101 aaatcatcga tgatgtaaat ggtgtaacac ttgctagtgc atctactctc gataaagact 143161 tgaacgttga aagcactgga gatacttctg ctgctactaa agttggagaa ttagttgcaa 143221 aacgcgctgc tgaaaaaggc atttctgacg tagtatttga ccgtggcgga tacttatacc 143281 atggacgtgt aaaagctttg gctgatgccg ctcgtgaagc tggacttaaa ttttaataaa 143341 agaaggaggg acacatgatt atgcgtcgta ttgacccaag caaattagag ttagaagaac 143401 gcttagttac ggttaaccgc gtagcgaaag ttgttaaagg tggtcgtcgt ttccgcttcg 143461 cagctctagt cgttgtcggt gacaaaaacg gacacgtagg attcggtact ggtaaagcac 143521 aagaagtacc agaagcgatt cgcaaagctg ttgaagatgc gaaaaagaat ttgattgaag 143581 taccaatggt tggaactaca attccacacg aaatcatcgg acgtttcggt gcaggtaaca 143641 tcttgttaaa acctgcttct gaaggtactg gagttatcgc tggaggccct gtacgtgcgg 143701 tacttgagct agctggtgta gctgatatcc tttctaagtc tttaggttct aacacaccga 143761 tcaacatgat tcgtgcaaca cttcaaggtt taagtgaact taaacgtgct gaagacgttg 143821 cgaagcttcg tggaaaatct gtagaagaac tgttaggata aggagggaac attaatggct 143881 aaattagaaa ttaccctcaa acgaagtgta atcggtcgcc cggaagacca acgcgttact 143941 gtaagaacac ttggtttaaa gaaaacaaac caaactgttg ttcatgaaga caacgctgcg 144001 atccgtggta tgattaataa agtatctcat ttagtttctg ttaaagaaca ataaaaatat 144061 ttgatcggat aaggaggtgt cctaatgaaa cttcatgaat taaaaccttc agaaggttca 144121 cgcaaaacgc gtaatcgcgt aggtcgtggt attggttctg gcaacggtaa aacagctggt 144181 aaaggtcaca aaggtcaaaa cgctcgttct ggcggcggtg tacgccctgg attcgagggg 144241 ggacaaatgc ctttattcca acgtcttcct aaacgtggtt tcactaacat caaccgcaag 144301 gaatacgctg tagtcaacct agacaaattg aacggttttg cagaaggaac ggaagtcact 144361 cctgaacttc ttctagagac tggtgttatt agcaaactta atgcaggagt aaagattctt 144421 ggcaacggta aattagagaa aaaattaact gtaaaagcca ataaattctc tgcttctgcg 144481 aaagaagctg ttgaagctgc tggcggtaca gctgaggtga tctaacttgt ttaaaacaat 144541 ctccaacttt atgcgtgtga gtgatatcag gaataaaatc atattcactt tactcatgct 144601 tatcgtcttt cgcataggtg cgtttattcc tgtgccttac gttaacgctg aagcgttaca 144661 ggcacagtct caaatgggtg tttttgatct ccttaataca tttggcggcg gtgcgcttta 144721 ccaattttcc attttcgcaa tgggaattac tccttatatc acggcttcga tcatcattca 144781 gctgcttcag atggatgtgg taccgaagtt taccgagtgg tctaagcaag gtgaagttgg 144841 ccgccgtaaa ttagctcagt tcacaaggta ctttacgatt gtgcttggtt tcatccaagc 144901 gttaggtatg tcatatggat tcaacaatct ggcaaacggt atgctgatcg aaaaatccgg 144961 tgtatcgaca tatcttatca ttgctttagt gctcactggc ggaactgcct ttttaatgtg 145021 gcttggggaa caaattactt ctcatggagt aggcaacgga atatcgatca ttatcttcgc 145081 ggggattgtg tctagtattc caaaaacaat tgggcaaata tatgagactc aatttgtcgg 145141 cagcaacgat cagttgttta ttcatattgt gaaagtcgca cttcttgtga ttgcgatttt 145201 agcagttatt gttggagtta ttttcattca gcaagccgta cggaaaattg cgattcaata 145261 tgctaaaggc acaggtcgtt cacctgctgg cggaggtcag tctacacacc ttccattgaa 145321 agtgaatcct gcaggggtta ttccggtaat ctttgcggtt gcgtttttga taacgccgcg 145381 gacgatcgcg tcattctttg gaacaaacga tgtgacaaag tggattcaaa acaactttga 145441 taatacgcat ccggtgggta tggcgatata tgttgcgttg attattgcct ttacgtactt 145501 ttatgctttt gtacaggtaa accctgaaca aatggctgat aaccttaaaa aacagggtgg 145561 ctatatcccg ggggttcgtc cagggaaaat gactcaagat agaattacga gcattttgta 145621 tcgacttacg tttgtgggtt ctatattctt agccgtgatt tccattcttc ctatcttttt 145681 cattcaattc gctggattgc ctcaaagtgc acaaattggc ggaacatctt tgttaattgt 145741 tgtcggggta gccttggaga caatgaaaca actagaaagc cagttggtga aacgaaacta 145801 ccgtggattt atgaaaaact agaggaaatg gatttatcca ttccctctta ataaagagag 145861 gacgggggaa atccgaatga acttagtctt aatggggctt cctggtgccg gtaaaggcac 145921 acagggcgaa cgaattgttg aggattatgg gattcctcat atctcaacag gagatatgtt 145981 ccgtgctgct atgaaagaag aaacaccact cggactcgaa gcaaaatctt atattgataa 146041 gggagagctc gtacctgacg aagtcacaat cggaattgta aaagagagac ttggcaaaga 146101 tgattgtgaa agaggttttc ttctggacgg atttccgcga acagtcgctc aagccgaagc 146161 tcttgaagaa attcttgagg aatacggcaa gccgattgat tatgtcatta acattgaagt 146221 cgacaaagat gttctgatgg aacgtctgac tggacgcaga atttgcagtg tttgcggcac 146281 aacctatcat ttagtcttta atccgccgaa aacgccgggt atttgtgata aagacggagg 146341 cgaactctat caacgggcag atgataatga ggaaacagtc tctaaacggc ttgaggtaaa 146401 catgaagcaa actcagcctt tactcgattt ctattcagag aaaggttatc ttgcaaacgt 146461 gaatggccag caggacattc aagacgttta tgcagatgtg aaggatcttc ttggaggatt 146521 aaaaaaatga ttatctgtaa aaccccacgt gaacttggta tcatgcggga agcagggcga 146581 atcgtggctt taactcatga agagttaaaa aagcacatta aaccaggaat ctcgacaaaa 146641 gaattggatc aaattgccga acgttttatt aagaagcagg gtgcaatccc atcttttaag 146701 gggtataatg ggtttcgcgg gagcatttgc gtatcagtta atgaagaact cgttcacggc 146761 atacctggca gcagggtgct gaaggacggt gacatcatca gtattgatat cggtgctaaa 146821 ttaaatggtt atcatggtga ctctgcatgg acatatccgg taggaaacat cagcgatgat 146881 gacaaaaaac ttctggaagt gacagaggag tctttatata aaggcttgca ggaagcaaaa 146941 ccaggtgaac gtttgtcgaa tatttcccac gcaatacaaa cgtatgtcga aaatgagcag 147001 ttttcagttg ttagggagta tgtcggacat ggtgttggtc aagacttgca tgaggacccg 147061 caaattcctc attacggtcc gcccaacaaa ggaccacggc ttaaacctgg catggttctc 147121 gctattgaac ctatggtgaa cgctggcagc cgctacgtga aaacattggc tgataactgg 147181 acggttgtaa cggtagatgg gaaaaagtgt gctcattttg aacatacgat tgcgattacg 147241 gaaacgggtt ttgatatact gacgagagtc tagatgatga aaataattcc gaagacagat 147301 gtttttcaag cttgataggg cagaaagctt gggtgaacat tggcaagacc gaattcatct 147361 tgcttcttgt cgttggaatt ttaaccatca tcaatgtact aacagcagac ggagaaaagc 147421 gtacatttca ttctcctaag aaaaagaata tcaatcattt aaccctttat gattgcgtat 147481 ctccggaagt tcagaacagt ataaacgaaa cagggcgtgt gacaaacttc ttttgaaatt 147541 tgtcagaaag caagttactg atttgaagaa gggagaacac ttgaatggcg aaagacgatg 147601 taattgaagt ggaaggtact atagtcgaaa cactgccaaa cgcgatgttc aaagttgaac 147661 ttgaaaatgg ccacactgtt ttggctcatg tatctggtaa aatccgcatg cacttcattc 147721 gcattttacc tggagacaaa gttacggtag aattatctcc atatgactta actcgtggca 147781 ggattacgta ccgttacaaa taaagcactc cggaaactga aggaggttgg aaacacatga 147841 aagtgagacc atcagttaaa ccaatctgcg aaaaatgtaa agttattcgc agaaaaggaa 147901 aagtaatggt gatctgtgaa aatccaaagc ataaacaaaa acaaggataa tttataagga 147961 ggtgcccaga gaatggctcg tattgctggt gtagatatcc cacgtgacaa acgtgttgtt 148021 atttctttaa catacatctt cggaattggc cgcacaacgg ctcagcaagt tttaaaagaa 148081 gctggagttt cagaagatac tcgtgtgcgc gatcttactg aagaagaact tggtaaaatc 148141 cgtgatatta ttgacaaact gaaagtagaa ggtgaccttc gccgtgaagt ttctcttaat 148201 atcaaacgtc tgatcgaaat cggaagctac cgcggaatcc gtcatcgcag aggattacct 148261 gttcgcggac aaaactctaa aaacaacgcg cgtactcgta aaggtccgcg tcgtactgta 148321 gctaacaaga aaaaataagt aagggaggtt cttaaacaat ggctgctgct cgtaaatcta 148381 acacgcgtaa acgtcgcgtg aaaaagaata ttgagtctgg aattgctcat attcgttcaa 148441 ctttcaataa cacgatcgtt acgatcactg acactcatgg taatgctatt tcttggtcta 148501 gtgccggagc tttaggattc agaggttctc gtaaatctac tccttttgct gcgcaaatgg 148561 ctgcagaaac agctgctaaa ggttcaatcg aacatggtct taaaactcta gaggttactg 148621 ttaaaggacc tggttcaggc cgtgaagctg caatccgtgc acttcaagct gctggactag 148681 aagtcactgc tatcagagac gtaactcctg ttcctcataa cggatgccgt ccaccaaaac 148741 gtcgccgcgt gtaatttgtt tgtatagatt ttgtgtccct gtcaataatg ggttatgata 148801 cagttattta tgaaacgaat gcaccgactc gttgcctgag cacatacggg actaaacaat 148861 ggggaatttc ggatggaatc tcatatgatt ctattcgagg tttcgacgtt ttgaaggagg 148921 gttttaagta atgatcgaga ttgaaaaacc aaaaatcgaa acggttgaaa tcagcgacga 148981 tgccaaattt ggtaagtttg tcgtagagcc acttgagcgt ggatatggta caactctggg 149041 taactcctta cgtcgtatcc tcttatcctc actccctggt gccgctgtaa catcaatcca 149101 gatagatggt gtactgcacg aattctcgac aattgaaggc gttgtggaag atgttacaac 149161 gattatctta cacattaaaa agcttgcatt gaaaatctac tctgatgaag agaagacgct 149221 agaaattgat gtacagggtg aaggaactgt aacggcagct gatattacac acgatagtga 149281 tgtagagatc ttaaatcctg atcttcatat cgcgactctt ggtgagaatg cgagtttccg 149341 agttcgcctt actgctcaaa gaggacgtgg gtatacgcct gctgacgcaa acaagagaga 149401 cgatcagcca atcggcgtga ttccgatcga ttctatctat acgccagttt ctcgtgtatc 149461 ttatcaggta gagaacactc gtgtaggcca agttgcaaac tatgataaac ttacacttga 149521 tgtttggact gatggaagca ctggaccgaa agaagcaatt gcgcttggtt caaagatttt 149581 aactgaacac cttaatatat tcgttggttt aactgacgaa gctcaacatg ctgaaatcat 149641 ggttgaaaaa gaagaagatc aaaaagagaa agttcttgaa atgacaattg aagaattgga 149701 tctttctgtt cgttcttaca actgcttaaa gcgtgcgggt attaacacgg ttcaagagct 149761 tgcgaacaag acggaagaag atatgatgaa agttcgaaat ctaggacgca aatcacttga 149821 agaagtgaaa gcgaaactag aagaacttgg actcggactt cgcaaagacg attgactagt 149881 ttcccttgtg aactaggatt ttcgtgtgtt tattattcag aaacagcatt ccaataaagg 149941 aggggacatc acatgtcata cagaaaacta ggacgtacga gtgcacagcg taaagctatg 150001 cttcgtgatc ttacaactga tttgatcatc aacgaaagaa tcgaaacaac tgaaacacgt 150061 gcgaaagaac ttcgctctgt agttgaaaaa atgatcacgc ttggcaaacg cggtgatctt 150121 cacgctcgcc gtcaagctgc tgcatacatc cgcaacgagg ttgcaaacga agaaaataat 150181 caagatgcac ttcaaaaatt attctctgac attgcaactc gttacgagga gcgccaaggt 150241 ggatacacac gtattatgaa gcttggtcct cgccgtggtg acggagcacc aatggcaatt 150301 atcgaattgg tttaatcaca tatttttgtg tatctaaaga agggcgggac agtttctaac 150361 tggatctatg cccttttttt agatactgca acttttaata gagagaaaag cagagcatta 150421 gctgagagga ggccggtttt ccatgaatca aaatcagttg atatcggtag aggatatcgt 150481 atttcgatat cggaaggacg cagaaagacg agcactagac ggcgtctccc tgcaggtgta 150541 tgagggtgaa tggcttgcaa tcgtaggtca taacggttca gggaaatcaa cactggcccg 150601 ggcattgaat ggtttaattc ttcctgaatc aggcgacatt gaggttgccg ggattcaatt 150661 gacagaggaa tctgtttggg aagtgcgtaa gaagataggt atggtctttc aaaatccgga 150721 taaccaattt gtcggaacga ctgttcgcga tgatgtggct tttggtttag aaaacaatgg 150781 tgtaccgcgg gaagaaatga ttgagagagt agactgggca gtaaaacagg tgaatatgca 150841 agattttctc gatcaagagc cgcaccatct ctccggaggc caaaagcaga gagttgcgat 150901 tgcgggggtt attgccgcac gtcctgatat tattatctta gatgaagcaa catccatgct 150961 tgatccgatc gggcgagaag aagtgcttga aacggtaaga catttaaaag agcagggcat 151021 ggcgactgtc atatccatta cacatgacct gaatgaggca gcaaaagcag acaggatcat 151081 tgtcatgaat ggcggtaaaa aatatgctga agggccgcct gaagagattt ttaaattgaa 151141 taaagaactt gttcgaattg ggcttgattt acccttctca ttccagctta gccagctttt 151201 aagagaaaat ggactggctt tggaagaaaa ccatttgact caggaagggc tggtgaaaga 151261 gctgtggaca ttacaatcaa agatgtagag catcgctatc agatgaagac cccgtttgag 151321 cgcctagcac tgtatgatat caatgcatcg attaaagaag gaagctacgt agccgttatc 151381 gggcatacag gctctggcaa gtccactctt ctacagcacc taaatggtct cctgaagccg 151441 acgaagggac agatatcact aggcagcact gtcattcagg cagggaaaaa gaataaagat 151501 ctgaaaaaac ttcgtaaaaa agtcggaatc gttttccaat ttcctgagca tcaattattc 151561 gaagaaacag ttcttaaaga tatttcattc ggaccgatga actttggtgt taaaaaagaa 151621 gatgctgaac aaaaagcgag agagatgctg cagcttgtag gtttatcaga agagcttttg 151681 gacaggtcac cctttgaatt aagcggggga caaatgcgca gagttgcaat tgccggcgta 151741 cttgcaatgg accctgaagt gcttgttctg gatgaaccga ctgcaggatt ggacccaaga 151801 gggcgaaaag agattatgga catgttttat gagcttcatc aacgtgggaa cttgacgacg 151861 atccttgtga cacacagcat ggaggatgca gctgcatacg ctgatgaaat gattgttatg 151921 cataaaggaa cgatacaagc atcaggcagt ccgcgtgatc tgtttttaaa gggtgaagag 151981 atggccggct gggggctgga tcttcctgaa acaataaaat tccaaagaca ccttgaagct 152041 gcactgggtg tgagatttaa tgagcctatg ctcacaatcg aagatgccgc tgccgaaatc 152101 cgtgctcttt ttcagggaga gaagacttta tgatggacag catgattatc ggcaagtatg 152161 taccggggac ttcacttgtg caccggcttg accccagaac aaaactgatc acgatctttt 152221 tatttgtctg cattgtattc ttagccaata atgttcagac atatgcgttg cttggtttat 152281 ttacaattgg cgtcgtttct ttaacaagag ttcctttctc ttttttaatg aaagggctga 152341 agccaatcat ctggattgtc ctttttacgt tccttcttca cattcttatg acacatgaag 152401 gaccgattat ctttcaaata ggttttttca aagtctatga gggcggtctg gttcagggga 152461 tattcatttc tcttagattc gtctatttga ttttaatcac aaccttatta acgcttacga 152521 ctacaccgat tgagattacc gatggaatgg agcagctgct gaacccattg aaaaaattaa 152581 agcttcctgt tcatgagctg gctcttatga tgtcaatttc tttacggttt attccgacac 152641 tgatggagga gacagataag atcatgaagg ctcagatggc gcgaggcgtt gattttacaa 152701 gcgggcctgt caaagaaaga gtgaaggcta ttgtcccgct tcttgtcccg ctcttcgtca 152761 gcgcatttaa acgcgccgaa gagcttgcgg tggcaatgga agcaagaggc tatcaaggcg 152821 gagaaggacg tacgaaatat agaaagcttg tatggacagg aaaagacact tctgtcattg 152881 tcagcttaat tgtattagct gctttgttat ttttcttaag ggcttagagg tgctgtatga 152941 gactgaaatg cacgatttct tatgacggac atttgtttaa cggttatcag gttcagccgg 153001 gcaaaagaac ggttcaggat gaactggaga aggctttggc tgtcctgcat aagtcaaaag 153061 acagaattcc ggtcgtttcg tctggaagaa cagacagcgg ggttcacgca gccggacagg 153121 tgattcattt tgacactccg ctgtctatcc cggctgagag atggccatat gccttaaatg 153181 cactgcttcc ggacgatatc gcagtcaaac aggcagaaat tgcggatgat gggttccatg 153241 cacgatttag cgcagtcaaa aaagaatatc gctactttgt atacacggag aaacacccgg 153301 acgtatttaa acggcattac gcttaccatt tttcatatcg ccttaatgtg caggacatga 153361 gagaagcggc aaagcatctt atagggacac atgattttac gagcttttgc gcggctaaaa 153421 cagaagtgca ggacaaggta agaacgatat acgaacttga ttggactgag acggctgacg 153481 gcctgcaaat gcggatcaca ggcagcggtt tcttatataa tatggtcaga attattgcgg 153541 gtactttgct tgatgcaggt attggaaaaa tttctcccga tgaggtgaaa tccatgctgg 153601 aagcgaagga tcgcgaagcg gcagggcgca cagcgccggg gcacgggcta tatttatgga 153661 acgtttacta tgacaactaa accaggtgta taatattttc ttgacagagt ctgcataaag 153721 ttataagata tcatatggta tgtatttcaa ccccacgata agccccggaa cttattgtgt 153781 tgtgaaatag aacgtaatcg aagtttattg aaaatgacag atcatttagg agggaaattc 153841 aatgcgtaca acacctatgg ctaacgcaag tactattgaa cgcaagtggt tagttgttga 153901 tgctgctggc aagactttag gtcgtctttc ttcagaagtt gcagctatcc ttcgcggaaa 153961 acacaaacca acttacacac cacacgttga tactggagat catgtgatca tcatcaacgc 154021 tgaaaaaatc gagttaactg gtaaaaagtt aactgacaaa atctactacc gtcacactca 154081 acatccaggc ggattaaaat caagaactgc tcttgaaatg cgtacaaact accctgagaa 154141 aatgcttgag cttgctatca aaggcatgct tccaaaaggt tctctaggtc gtcaaatgtt 154201 caaaaaattg aacgtatacc gtggttctga gcatccacac gaagcacaaa aacctgaagt 154261 ttacgaactt cgcggttaat taaaaaggag gttaccaatt tggcacaggt tcaatattac 154321 ggtactggcc gtcgtaaaag ctctgtagcg cgtgtgcgtt tagttccagg agaaggccgt 154381 atcgtcgtta ataatcgtga aatcagcgaa catatcccat ctgcagcttt aatcgaagat 154441 atcaaacaac cattaacttt gactgaaaca gctggcactt atgatgtttt agtaaacgta 154501 catggaggcg gcctatctgg tcaagctgga gcaatccgtc acggtatcgc tcgtgctttg 154561 cttgaagcag atccagaata ccgtacaact cttaaacgtg caggtcttct gactcgtgac 154621 gctcgtatga aagaacgtaa aaaatacggt cttaaaggcg ctcgtcgtgc acctcagttc 154681 tcaaaacgtt aattttacgt tttcaaaaag ctctcgacct tgggttggga gcttttttct 154741 ttcaataaaa cgtggcagtc ccgcataaaa ataacaactg aatggacgct tgacggggtt 154801 aagcaaattg tttgtttata aacggtctct ttgtaataat catggtagat ttcattctta 154861 ttcaattgga agttcggtca atgtttatta tcgttatgtg atcagcccag ctccatctaa 154921 ccactgtatc tcatccgtta aagttcactg ctgattctta acccggagaa acaatagctc 154981 tcattgctaa tggctttatg taacgaagta aaagtaaatc tgatgatata aatcacatat 155041 ctcctttgtg atttttttgc gtttttatga acttttttct aaatatgcaa agggaaagcg 155101 atatcaatct agaaatattt gttatactct atacattaaa gtaaggagaa gattcatgaa 155161 tgcgttagta gctcataata gcaaagcctg ggataaaaaa gtagaaacag gcaatgaatg 155221 gactgttgct gttgaacagc aggttatcga acaagcaaaa aaaggcaatt gggatataag 155281 ggtaacacca atgaaagatg taccgaagga ttggtttccg cctatcaaag gtctgaaagt 155341 actctgttta gcatcaggcg gcggccagca gggtccagtt ttggcagccg caggcgcgga 155401 tgtcactgta ttagataact cagaaaaaca gctgaatcag gatagaatga ttgctgagcg 155461 agatggtctg acgatacaca ctgtcaaagg aagcatggac gatttaagtg tatttaatga 155521 tgaatcattt gatgtcattg tacatcctgt tgccaatgtt tttgttgaga atgtcctccc 155581 ggtatggaag gaagcgtacc gtgtgttgaa aaggaacggc attctaatct cgggttttgt 155641 caatcctgtt gtatttctgt ttgatacaga attagaacag caaggtgttt taaaagtaaa 155701 acactctatt ccatacgctg acccagaaga tcttccgaaa cataaagtga aaaaactgat 155761 cgaaaataat gaggctctgg aattcggcca ttccttagaa gaccaaatca aaggccaaat 155821 tgatgccggt tttatcgtta ctggttttta tgaagataaa ggcggttttg tattagacca 155881 atatatccat acatattctg caacaagaag cgtgaaagta tgaaaagcag cgacctgtta 155941 gaggggctgc ttttttcata accaattaca gaacatttgt tcctcaccct gcagaaagct 156001 gattttttat caatgttaca ccttcatttg ggcgaatttc caaccgaatt cgggcattgt 156061 ttcatcatcc aaacctcaaa ataatcggta aaaggagagt gaatttatat ggcagaagta 156121 ctgtctttta tggatgtgaa acgccaaaag gattttgaat tagaaaagaa cttgctcaaa 156181 gaactctctc tgagacaaat tatccagtct gttaaggatt gtttggaacc attatttcca 156241 tttttacatg atgaacgaga tattattacc gaaggctgta ttgattttgc gattgaagct 156301 tatttgttag gcgggcgttt tgggatattc ggctattacg gagaatcaat gcagagtatc 156361 agtgcccgct ctgcaagaga agaagaagag ctgcgtatgg agttttttga ttatctctat 156421 aattggatac acgagcaata cgcaacattt gataaaaaca ctgtttatga agcggcacgc 156481 aagttcatta aagattggtg gacagcaggg tttgttcaaa gagaaaaaca gtgtaagctt 156541 cgcatgcggt aatcatattt cccgaccctg tcccatagtt atgtaataac ggacaagcgg 156601 gaggggaagg gatgaggaaa aagcttaaat ggctcagttt tttgctaggc ttcatcatat 156661 tactatttct gttcaagtat cagttcagca ataacgactc ttggaagccg tggagcctgc 156721 ccttgagcgg taaaatcatt tatctagatc caggtcatgg cgggcctgac ggcggagcag 156781 tcggcggaaa gctgttagag aaggatgtta ccctggaagt ggcctttaga gtcagggatt 156841 atcttcaaga acaaggagcg cttgttatca tgaccagaga aagtgatact gatctcgctc 156901 cagaaggaac aaaaggctat agccgacgaa aagctgagga tctaagacaa cgagtcaaat 156961 taataaacca ttcagaggcg gagctctata tcagcattca tcttaatgcg attccgtcac 157021 aaaaatggag cggagcccaa agcttttatt acgggaaata tgcggaaaat gagaaagtcg 157081 caaaatacat tcaggatgag ctgagaagaa atctggaaaa cacaacccgg aaagcaaagc 157141 ggattcatgg tatctactta atgcaaaacg tcaccaaacc gggggcgctt atagaagtcg 157201 gatttttatc caatccaagt gaagcaacgt tgctcggtaa accgaaatat caagacaagg 157261 tggcatcttc catatataaa ggcattttgc gatatttcac agaaaaagga gaccctccgg 157321 agtaatggag ggttttcttg tggttctaag cataagacac ccgccattta tgtatgatat 157381 aataataatt gtaaacgaat acacaaaagg gtgaggttcg atgataagag aagatgaagt 157441 aagaaaacta gtcggagaaa tgcgcgaacc ttttcttcaa agacctctgg gagaattgga 157501 tgccgttaag gaaattaaaa taaagcctga aaaacggcat atcagtgtaa aagtcgctct 157561 tgcaaaaaca ggaactgcag aacaaatgca gattcagcaa gagatcgtaa acgtattaaa 157621 aggggcagga gctgagacag tcggccttcg atttgaagag ctgcctgaag aaacggttgc 157681 taaattccgg gcgccgtcag ctgagaaaaa aacattatta aatatggata acccgccagt 157741 ctttcttgct gtagcaagtg gaaaaggcgg cgtaggcaag tcaactgtgt cagtaaacct 157801 agctatttct ctggctcgtc tagggaaaaa ggttggttta attgatgcgg atatttatgg 157861 gttcagtgtg ccggacatga tgggtatcac tgtgcgtcca acaattgaag gagagaaact 157921 tcttcctgtt gaacgctttg gagtaaaggt catgtcaatg ggctttttcg tagaagaaaa 157981 tgccccggtc gtatggagag ggccgatgct cggcaaaatg ctgaataatt ttttccatga 158041 agtagagtgg ggagaagtag actatatcgt tcttgatctt ccgcctggta caggggacgt 158101 tgctctcgat gtacatacaa tgcttccgag ctgcaaagaa attatcgtat ctacgccaca 158161 tccgacagct gcttttgtcg cggccagagc gggctctatg gcgattaaaa ccgatcatga 158221 ggtcgtgggt gtcatagaga acatggctta ttatgaaagt gcaaagacag gggaaagaga 158281 atatgtgttt ggaaaaggcg gaggagataa actggctgag gaactaaacg tgcctttgct 158341 cggcagaatc ccattgaaac agcccgattg ggataaggac caatttgctc cgtctgttta 158401 tgacgaaaat catccaatcg gagaaatata tcaggacatc gcaaaaaaaa tagatgcaaa 158461 aatgtcagtg caggtataaa aggtgaaccg ggattccaga tcccggcttt ccctttattc 158521 actttctttt gctgtgtctt ttgctgcttt tttcagctca tcttcgaact gctttttgta 158581 aagcggacta gaaagtgttt cgttaataac ctcttctaaa taactgcgga attcttggct 158641 ttttgccagc tggctgtact ttttatccat gccgggatcc tgcataacgc tcatcagcat 158701 cttctggtaa tctggatcct tcatcagctt tttaatcact ttttcatgct ctgtctgaag 158761 agttttggca aagccctcag caaaatcagt gtcttcaaag atgtttttcc aaaattcttc 158821 acctttttta gatgtgagtg ttttttctat tgttccttta attgcatctt ggtcaatcac 158881 cagcgcttca ttcatggcat catcatttaa taattcctta atagctttct ttccatcatc 158941 agtttttaat atatcaacaa ccattttttt ggtctgatca tagtccatat ccgctgcttg 159001 gtcttttgga gcgcaagctg ttacagataa taacaaaaaa cagctcatca atagcgtttt 159061 ggcttttgac atgcttaagc tcctttcaca tacttgtctt acctttaata tgattcatct 159121 gtttggaatt atacataaca aaatatcgct gttcgcgatt tttgagggga tgaataaaga 159181 aatgaaaagc cgtggtttag ttcgtttttt cttttctatt ttagctgtcg gggcgcttat 159241 cacgagtatt gtgggttttg ctttaaagtg gggagaatat agagggctgt ttctaacatt 159301 tgaagcggga cagattttct ctgttttatt ttggtttatc ggtgtaggca tgattttcag 159361 tgtgatcagc caaatgggtt ttttcgtgtt tttaacagtt catcggtttg cgcttgagat 159421 attaaggtcc tcctctttgt ggaatttgct gcagttgttt ttcatcctgt ttgttgcttt 159481 tgatttaatg tacgtgcgtt ttttattttt tggagagagc ggagaatcgc tggctggcta 159541 tgcgtggtta ccggtgtttt tattgatctt tggagtgatt acagcttata taaagcaaaa 159601 gcagtcctct aagaaaacat ttgtgtcatc gttatttttg atggttgtga ttaccgcatt 159661 agaatggttc cctgcattaa gagtaaatga tgaggactgg ctttatttaa tgctttttcc 159721 gttaatggca tgtaatgcct tccaattgct gatgctgccg aagtttgcag caaagtaatt 159781 actttacctc tgcggatttg gcatcagaat ttgcgatgag atcacccacg gttacatttt 159841 ttaatccttt ttctttcagc tgatggatga tatcaggcaa tgcttcttct gtttgttttg 159901 cagaatcgga ggcatgtaaa agaataatgt ctccaccgga aacttgcttg gtcacattgt 159961 cgatgatttt ttcaactccg ggatttgtcc agtcttgaga gttcacactg taatgaacga 160021 ctgtataatt gtattgcttt gcgaccttta gaacattctt attgaattgg ccggtagggg 160081 gtcttaatag ctgtatgtct ttgaccccta acttttcaaa ggctgtttgc gcacggttca 160141 tgtccttttt tatttcgctg ctctctaaat tggcatagtt tttataagcg tagcccatgc 160201 tcccgatttg atggccgtcc tttacgatac gggccactgt gtcgggatgg cgttctgccc 160261 aagaagcgga caggaaaaac gttgcgtttt taatcccgtt tgctttcaga gtattaagta 160321 tcggttctgc tctctcatca ccccagctga tatcgaaagt aagtgaaata tctttagagt 160381 ctgtttctcc tttataaatg gctttaggtc cggtgtcagt tgaaaacacg ggaagcggga 160441 cagctctttg gatataaaaa aagctggcag ctgcaaatgc ggcgataagt ataataatta 160501 attgttttac ccgtttaatg tgccacacat agaagtgatt cactgatgat gcctccttat 160561 cttgtccatc attcttgttt tacatcttat gagcatggac aattgaatat aaccgataaa 160621 atgtctcttc acatacagcc taaattgggt gttgaccttt tgataatatc cgtgatatat 160681 tattattcgt cgctgataaa cagctgacat caactaaaag cttcattaaa tactttgaaa 160741 aaagttgttg acttaaaaga agctaaatgt tatagtaata aagctgcttc gttaagcggc 160801 agtaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcat ttttataaat 160861 cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat cctggctcag 160921 gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg gagcttgctc 160981 cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta agactgggat 161041 aactccggga aaccggggct aataccggat ggttgtttga accgcatggt tcaaacataa 161101 aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag ttggtgaggt 161161 aatggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc cacactggga 161221 ctgagacacg gcccagactc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 161281 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 161341 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 161401 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagctt tgtccggaat 161461 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 161521 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 161581 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 161641 gtctgtaact gacgctgagg agcgaaaacg tggggagcga acaggattag ataccctggt 161701 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 161761 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 161821 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 161881 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 161941 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 162001 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 162061 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 162121 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 162181 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 162241 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 162301 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 162361 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 162421 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 162481 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 162541 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 162601 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 162661 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 162721 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 162781 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 162841 tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga ggcttgcctc 162901 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 162961 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 163021 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 163081 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 163141 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 163201 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 163261 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 163321 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 163381 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 163441 ccaatcgagc ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 163501 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 163561 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 163621 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 163681 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 163741 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 163801 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 163861 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 163921 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 163981 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 164041 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 164101 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 164161 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 164221 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 164281 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 164341 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 164401 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 164461 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 164521 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 164581 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 164641 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 164701 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 164761 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 164821 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtttca ggtgggcagt 164881 ttgactgggg cggtcgcctc ctaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg 164941 ttggaaatca ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc 165001 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc 165061 aacggataaa agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg 165121 gggaggtttg gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg 165181 gttgggctgt tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt 165241 tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg 165301 accgggatgg acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct 165361 atgtgcggac gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat 165421 ttcccattcc gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg 165481 gaagtgtggc gacacatgga gctgacagat actaatcgat cgaggactta accatatttt 165541 tgaatgatgt cacatctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg 165601 atagcgaaga ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg 165661 atggtagtcg ggggtttccc cctgtgagag taggacgccg ccaagcagat ttattaattc 165721 taccatgttt gtttatgaag ctttatatct cattccgcag tagctcagtg gtagagctat 165781 cggctgttaa ccgatcggtc gtaggttcga atcctacctg cggagcattg cttccatagc 165841 tcagcaggta gagcacttcc atggtaagga agaggtcagc ggttcgagcc cgcttggaag 165901 cttaaatgta ttattaccaa ggtttctcat aaggagaaag ctttttttat tgcgatatgc 165961 ggaagtagtt cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc 166021 gtcttccgct ccatttacct aacgggatat tgtaaattga attgcgcccg tagctcaatt 166081 ggatagagcg tttgactacg gatcaaaagg ttaggggttc gactcctctc gggcgcgcca 166141 tatcttttaa tagaatagat aggaaatcgg gaagtagctc agcttggtag agcacatggt 166201 ttgggaccat ggggtcgcag gttcgaatcc tgtcttcccg accatttttt atggggcctt 166261 agctcagctg ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg 166321 ctccaccaaa agtttttaaa aaaggttatt gactttgaag aagtgacatt gtatactaat 166381 aaagttgctt taacaaagcg gacaaacaaa atgatctttg aaaactaaac aagacaaaac 166441 gtacctgtta attcagtttt taaaaatcgc acagcgatgt gcgtagtcag tcaaactact 166501 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 166561 gtcgagcgga cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 166621 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 166681 tgtttgaacc gcatggttca aacctaaaag gtggcttcgg ctaccactta cagatggacc 166741 cgcggcgcat tagctagttg gtgaggtaac ggctcaccaa ggcaacgatg cgtagccgac 166801 ctgagagggt gatccggcca cactgggact gagacacggc ccagactcta cgggaggcag 166861 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 166921 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 166981 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 167041 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 167101 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt 167161 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 167221 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 167281 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 167341 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 167401 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 167461 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 167521 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 167581 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 167641 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 167701 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 167761 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 167821 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 167881 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 167941 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 168001 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 168061 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 168121 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 168181 aagtaataca agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg 168241 gtggatgcct tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg 168301 agctgtaagc aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg 168361 agtggtatcc atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat 168421 ctaagtaccc ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg 168481 gattagccca aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac 168541 aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt 168601 agtcaaaact tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg 168661 tcggaatccg ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc 168721 agtaccgtga gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc 168781 gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa 168841 ccggcgagtt acgatctcgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga 168901 gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt 168961 ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc 169021 ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc 169081 cgaaatagct ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac 169141 taggggcccc taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt 169201 gggagtcaga ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag 169261 ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga 169321 tgttggctta gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact 169381 ctggcccgaa aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac 169441 agtggtagga gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt 169501 agaagtgaga atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc 169561 ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg 169621 aaaggcgtag gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc 169681 aatgggggga cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt 169741 aggctgggaa ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata 169801 tagtagcgaa gttcctgatt ccacactgcc aagaaaagct ctagcgaggt gagaggtgcc 169861 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 169921 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgcc ctgttagggt 169981 gcaacccgag agaaccgcag tgaataggcc ccaggcgact gtttagcaaa acacaggtct 170041 ctgcgaagcc gtaaggcgaa gtatagggct gacgcctgcc cggtgctgga aggttaagag 170101 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 170161 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 170221 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 170281 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 170341 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca cttcggtgga 170401 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 170461 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 170521 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 170581 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 170641 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 170701 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 170761 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 170821 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 170881 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 170941 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 171001 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 171061 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 171121 atcgatcgag gacttaacca tatttttgaa tgatgtcaca cctgttatct agttttgaga 171181 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 171241 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 171301 acgccgccaa gcaattgcac attagtgtaa ttttttaaaa aagttattga ctttgaagaa 171361 gtgacattgt atactaataa agttgcttta acaaagcgga caaacaaaat gatctttgaa 171421 aactaaacaa gacaaaacgt acctgttaat tcagttttta aaaatcgcac agcgatgtgc 171481 gtagtcagtc aaactacttt atcggagagt ttgatcctgg ctcaggacga acgctggcgg 171541 cgtgcctaat acatgcaagt cgagcggaca gatgggagct tgctccctga tgttagcggc 171601 ggacgggtga gtaacacgtg ggtaacctgc ctgtaagact gggataactc cgggaaaccg 171661 gggctaatac cggatggtta gtttgaaccg catggttcaa acataaaagg tggcttcggc 171721 taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg gctcaccaag 171781 gcaacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga gacacggccc 171841 agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt ctgacggagc 171901 aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag ggaagaacaa 171961 gtaccgttcg aatagggcgg taccttgacg gtacctaacc agaaagccac ggctaactac 172021 gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat tgggcgtaaa 172081 gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc ggggagggtc 172141 attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt gtagcggtga 172201 aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc tgtaactgac 172261 gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta 172321 aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct aacgcattaa 172381 gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga cgggggcccg 172441 cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg 172501 acatcctctg acaatcctag agataggact gtcttcgggg gcagagtgac aggtggtgca 172561 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 172621 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 172681 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 172741 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 172801 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 172861 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 172921 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaagtggga 172981 cagatgattg gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc 173041 tcctttctaa ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc 173101 tgtcttgttt agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac 173161 agtagacatc acattcaagt aatacaagat atcacatagt gattcttttt aacggttaag 173221 ttagaaaggg cgcacggtgg atgccttggc actaggagcc gatgaaggac gggacgaaca 173281 ccgatatgct tcggggagct gtaagcaagc tttgatccgg agatttccga atggggaaac 173341 ccaccactcg taatggagtg gtatccatat ctgaattcat aggatatgag aaggcagacc 173401 cggggaactg aaacatctaa gtacccggag gaagagaaag caaatgcgat tccctgagta 173461 gcggcgagcg aaacgggatt agcccaaacc aagaggcttg cctcttgggg ttgtaggaca 173521 ctctgtacgg agttacaaag gaacgaggta gatgaagagg tctggaaagg cccgccatag 173581 gaggtaacag ccctgtagtc aaaacttcgt tctctcctga gtggatcctg agtacggcgg 173641 aacacgtgaa attccgtcgg aatccgggag gaccatctcc caaggctaaa tactccctag 173701 tgaccgatag tgaaccagta ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga 173761 aagagatcct gaaaccgtgt gcctacaagt agtcagagcc cgttaacggg tgatggcgtg 173821 ccttttgtag aatgaaccgg cgagttacga tctcgtgcaa ggttaagcag aagatgcgga 173881 gccgcagcga aagcgagtct gaatagggcg catgagtacg tggtcgtaga cccgaaacca 173941 ggtgatctac ccatgtccag ggtgaagttc aggtaacact gaatggaggc ccgaacccac 174001 gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga 174061 gatagctggt tctctccgaa atagctttag ggctagcctc aaggtaagag tcttggaggt 174121 agagcactga ttggactagg ggcccctacc gggttaccga attcagtcaa actccgaatg 174181 ccaatgactt atccttggga gtcagactgc gagtgataag atccgtagtc gaaagggaaa 174241 cagcccagac cgccagctaa ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt 174301 gcttagacaa ccaggatgtt ggcttagaag cagccaccat ttaaagagtg cgtaatagct 174361 cactggtcga gtgactctgc gccgaaaatg taccggggct aaacgtatca ccgaagctgc 174421 ggactgttct tcgaacagtg gtaggagagc gttctaaggg ctgtgaagcc agaccggaag 174481 gactggtgga gcgcttagaa gtgagaatgc cggtatgagt agcgaaagag gggtgagaat 174541 cccctccacc gaatgcctaa ggtttcctga ggaaggctcg tccgctcagg gttagtcggg 174601 acctaagccg aggccgaaag gcgtaggcga tggacaacag gttgatattc ctgtaccacc 174661 tcctcaccat ttgagcaatg gggggacgca ggaggatagg gtaagcgcgg tattggatat 174721 ccgcgtccaa gcagttaggc tgggaaatag ggaaatccgt ttcccataag gctgagctgt 174781 gatggcgagc gaaatatagt agcgaagttc ctgattccac actgccaaga aaagcctcta 174841 gcgaggtgag aggtgcccgt accgcaaacc gacacaggta ggcgaggaga gaatcctaag 174901 gtgatcgaga gaactctcgt taaggaactc ggcaaaatga ccccgtaact tcgggagaag 174961 gggtgctctg ttagggtgca agcccgagag agccgcagtg aataggccca ggcgactgtt 175021 tagcaaaaac acaggtctct gcgaagccgt aaggcgaagt ataggggctg acgcctgccc 175081 ggtgctggaa ggttaagagg agcgcttagc gtaagcgaag gtgcgaattg aagccccagt 175141 aaacggcggc cgtaactata acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc 175201 gacccgcacg aaaggcgcaa cgatctgggc actgtctcaa cgagagactc ggtgaaatta 175261 tagtacctgt gaagatgcag gttacccgcg acaggacgga aagaccccgt ggagctttac 175321 tgcagcctga tattgaatgt tggtacagct tgtacaggat aggtaggagc cttggaaacc 175381 ggagcgccag cttcggtgga ggcatcggtg ggatactacc ctggctgtat tgaccttcta 175441 acccgccgcc cttatcgggc ggggagacag tgtcaggtgg gcagtttgac tggggcggtc 175501 gcctcctaaa aggtaacgga ggcgcccaaa ggttccctca gaatggttgg aaatcattcg 175561 cagagtgtaa aggcacaagg gagcttgact gcgagaccta caagtcgagc agggacgaaa 175621 gtcgggctta gtgatccggt ggttccgcat ggaagggcca tcgctcaacg gataaaagct 175681 accccgggga taacaggctt atctccccca agagtccaca tcgacgggga ggtttggcac 175741 ctcgatgtcg gctcatcgca tcctggggct gtagtcggtc ccaagggttg ggctgttcgc 175801 ccattaaagc ggtacgcgag ctgggttcag aacgtcgtga gacagttcgg tccctatccg 175861 tcgcgggcgc aggaaatttg agaggagctg tccttagtac gagaggaccg ggatggacgc 175921 accgctggtg taccagttgt tctgccaagg gcatcgctgg gtagctatgt gcggacggga 175981 taagtgctga aagcatctaa gcatgaagcc cccctcaaga tgagatttcc cattccgcaa 176041 ggaagtaaga tccctgaaag atgatcaggt tgataggtct gaggtggaag tgtggcgaca 176101 catggagctg acagatacta atcgatcgag gacttaacca tatttttgaa tgatgtcaca 176161 cctgttatct agttttgaga gaacactctc aatttgtttg gtggcgatag cgaagaggtc 176221 acacccgttc ccataccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 176281 tttccccctg tgagagtagg acgccgccaa gcaagcttaa acccagctca ttgagctggg 176341 ttttttgttt tatatctgtg ccgatttgct ttcgtcagta tccattttat caagcttctg 176401 ctttttaaag ttttctaata cttttgaatt ccaatacaat ccctagcatg atcaacatga 176461 gagtcataaa taatcaaaat gcagtttgta cgggagactc atccagactc catccgactg 176521 cgattggcag gatagagccg ccaatccatt ggcagcgaac agcatgcttg tcgtttgttc 176581 tgtttttcca tgataaaatt gattggtgac aataaaataa tggcgaacat gccggccata 176641 aataagtcct aagaaaaaac taagaataat ccctgcaaaa gctgttttat tgattgccaa 176701 aatacagagt taaatgaggc cgctcatatt tatcagcctg agataatgat gataggttat 176761 tttttcggaa accagctcgg gttgccaaat gagagaaaag atattactgt cattaaaacg 176821 attcttggtt tcatccggat atgataaaat gtctcagact atatttgagc catttttttc 176881 ttcagcaatc atcttgcgta attgataaaa atttattatg atactctttg tatgacaact 176941 ccttgcctca atacaatata ctcaacgttt ccccgttttc tccggtcgtt tttcttttca 177001 ttttctcccg taaaataaaa aaagctccca atacaataga tatggtgcgg atttattttt 177061 tactaaaaag gagtcgttat atttgaataa tagttttaca ttaaaacagc aatggttcgg 177121 gaatatccga aaagacattc ttgctggcat tttagttgcg ttagcgttaa tacctgaagc 177181 gattggcttt tctattatag ccggtgtgga tccgatggtc ggtctttatg cgtcattttg 177241 catagccatt attatttcta tttttggtgg cagacctggc atgatttcag ctgcgacagg 177301 ctcaatggca gtcgttatgg tgtcgctggt tgctgatcat gggcttcagt atttatttgc 177361 ggctacgatt ttgacaggca ttattcaggt gattttaggt atcagtaaaa ttgcaagatt 177421 aatgaaattc atcccgcgtt ctgtgatgat cgggtttgtg aatgcgctgg cgatccttat 177481 cttctctgcg cagcttcccc agtttgaagg tgcttcttgg agcatgtatg cgatgcttgc 177541 cgggtcgttg gttattattt atgtgctgcc aaggtttacg actgctgttc cgtctccgct 177601 tgtggcgatt attgtgatga caattattgc ggtcactttc catgtggatg tgcggacggt 177661 tggtgatatg ggcaatattt ctagttcatt gcctcatttc ttaatccctg atgttccgtt 177721 tacctttgaa acactgcaaa ttatttttcc ttattcaatt gctttagcgt ttgtcgggtt 177781 gcttgaatct ttgctgacag cacagattat tgatgaaatg acggatacgg atagtgataa 177841 aaataaagag agccgcggac agggaattgc gaatatcgtg actggattct ttggcggaat 177901 ggcaggctgc gctatgatcg gacaatctgt cattaataca aaagcgggcg gtcgcggacg 177961 tttgtcagca tttgttgccg gtgcttttct gatgttttta attgcggtgt taagtcatgt 178021 cgtggtgaaa atcccaatgg cggcgttagt agctgtaatg gttatggtgt ctgtcggcac 178081 ttttgattgg tcttctttaa aaggtctcaa aaaagcgccg ctcacggact cgattgtcat 178141 ggttgtgact gtggttacgg ttgttgtgac ggatgactta tctaagggtg tatttgtcgg 178201 tgttctttta agtgccgtgt tctttgtagc aaaaatctcg aagctgaaaa tcgtttctca 178261 tgcagaggat caaaagctta gaacgtatca agtgaagggg caaatctttt ttgcgtcagt 178321 gactgatctt acgaatgcgt ttatatatca agaggatatt gagcgggttg tgattgactt 178381 aactgaagct cacgtatggg acgattctgg tgcggccgca cttgataaga ttgttgcgaa 178441 gtttaaggaa caaggcattg aagctgagtt aaaaggtttg aataaagcga gtaaatctct 178501 aatgaaacag atggcataaa atagagaagc ccagatgaat gagatctggg cttttttata 178561 taacatacac ttaagcagca ttgatataat agagagaaga gaaattttaa ataggggact 178621 tgcatatgat gcttcagaag ctgaaccgtg tattggggag agtgatgccg ctgttaacgc 178681 cgactagtgt ggtgctgggc gtgctgctgt ctcagttttt aaatgggtat gaatgggctg 178741 tgccttggat ctttgctttt attacgtttg caggcagttt gagcgcgaac tttcaatctt 178801 tgagacatgc attgtctcat cctctcccta tgattcttgc actattcgtt cttcatattt 178861 tcatgccgct ttttgcttgg ggcagcggcc atcttatatt taaaggtgat cctttgacga 178921 ttaccggttt aacattggct gttgtgattc ctacggggat tacaagcttg atttgggcag 178981 cgatgtacaa agggaatgtc ggtttgacac tttcgattat tttagttgat actgtgctgt 179041 caccgctaat cgtaccgctg agtctttcat tgctggccgg cgctcaggtt cacatggatg 179101 tgtggggaat gatgaaaggt ctgattgtaa tggtcgtgat tccttctttt ttgggcatgc 179161 tgtttaatca gatgtcatct ccagaaagaa ctgcgtttgt gagcagtgcg ctgtcgcctt 179221 tttcaaagct ttgcttgatg gcagtgattg cgattaacag ttcagcgatt gctccttatt 179281 tcaaatccat tgatttgaga tttgcaggaa tagctgtaac ggtattcttt atcgcgttaa 179341 caggttatgc cgctgcttgg ctgatcggaa aaatgatgaa aaggcggcaa gaggaaatag 179401 tctctcttat atttacggga ggcatgagga atattagtgc cggcgcagtt cttgccgtta 179461 cgttcttccc gtctcaggtt gccgttcctg ttgtgatcgg catgctgttt cagcagatat 179521 tggctgcttt gtttggctat atgctgaatc gttttgaatt aaaaccaatg ttgcagaagg 179581 cataaaaaaa ccgctcatag ggttgagcgg ttttttccgt atagccattc gagcgcgttg 179641 atgaactgtt tgcagaaata cttgtggtgg tgcaccgctc ctttttcaat tgaaagacac 179701 aactggtctt cagtgaagcc tttttctttt agactttgat gaacttgctt tgtttttttc 179761 agcatatgtc gctgaatgga ttgtttttca cggccttctt cactcccgat agacatgaaa 179821 acacgtgcag tgccgggctt taaagaagat atatgaatgg tttccgctgc gttctcgtac 179881 cagtatgaac ctgatataga gcctattttc ccgaacattg acggatattt taatatggcg 179941 aacattgaga tgaggccgcc taatgaggca ccgatcattc ctcttgactg cggttccctg 180001 gtgacgttcc agttttcttc gattagcgga atgaactggt tcgttatatc agacagatag 180061 tgatatccca ttccgccgaa gtccgtgaac cgatcactga gtgatgcagc cggccatggg 180121 gtgtattcat caagccggtt ttcgggttcg ataccgatca gcacgagttc agggagcctt 180181 tgctgttgaa aggcgctttc tagtaattcg atttggtttt ggaacaaaga actgccatcc 180241 tgcacgtaaa cagcaggaaa tcccccgctg tctgtgctgt aggaaggagg gaggtacagc 180301 gtgaacctcc tgttgccggc tttgtgttct gaaagagatc ctttcaagca ttctccccct 180361 ttttttgctt gaaaagcaga tataagaaat aaggaactcc gaggatcgcc aaaatgatgc 180421 ctgcgggcac ttctgcgggc tgaaaaaaca gttttccggc aaagtctgcg cttatcacaa 180481 gaagcatccc gattaaaccg ctcagtggca ggatatagcg atgttcgacg ccagccagtc 180541 tccgtgagat atggggagca attaagccga caaacgccat acttcccgct acggagacac 180601 aggcgctgat gattgctaca caggcaacga gaaggatggt tttttcttta tttgatgaaa 180661 taccgaggct tctgactgtg tcttcatcaa aacgaatggt gtcgagcagg cgggatttgc 180721 cgataagaat cggtataaac agcagcatcc atgggagtac agctgtaata tacgtccagt 180781 tggcagacca gatgcttccg tttttccaca ccatggccat ttgatagtct tgcgggtcca 180841 tttttaaaga taaaaacaaa gacagggcgc tgaatcctga attgatcgca atccctacca 180901 aaataattct tcctgaatct aaattgcctc tgtgccatgc aaatatgtaa atcaggatcg 180961 ccgcgatgag cccgcctatc aatccaaaga gcggcattcc catcgctgca gctatggatg 181021 tcacttcctt ctggccttgg aataagagca taaacgctac aatgccagct cctgcccctg 181081 cgttgattcc gagaattcca gggtcagcaa gcccgtttct cgtgatggcc tggataacag 181141 cgcctgcaat gccaagaccg agtccaataa tagcagccat gacaacccgc ggcagtctta 181201 aatcgaacag caaaatttca tactgcggat tcgggtcgat ttgaaaaaga gtggagagca 181261 gctcagcagg acgaacagaa aatgatccgc tcgttaagct gaaatagctg acaacaagaa 181321 tcaaagcgat gaacaatgca tattttttag ccattttgct cccctccttt tcgtttaatt 181381 aaataaagga agaaaggtac gccgataatg gatgttacga cctcaatcgg tgtttcaaac 181441 ggatagttga taaatctgct tgcgagatca cacagggtta aaaagattcc gcccaaaata 181501 caggaacacg gaatcagcct gctgtaatca gagccgacga gaaatctcgt gatatgcgga 181561 acaaccaacc cgacaaacgc aatttttccg gccagcgcta cggcactgcc ggttagaatg 181621 atgacggaaa gcatcgccat gattttaatg gtttttttct tttgccccag gcttttagaa 181681 atgtcgtccc ctaatgatac agcggttacc tttttgctga gagaaatggc cattataatg 181741 ccaatcagga aaaacggagc ggcaagcttc aggaaatctg gactcatttg atgaagtctg 181801 gcactgtacc agaaactgag atcctgagaa atttgaaaat aaatcgacat ggccgctgat 181861 aagctgctga gcagcatgct tgtgactgtg ccgatgatgg cgagctgcac gggggtaaat 181921 ccgtttggca tcatggcggc aaggccgaat actaacaccg ctcctaacgc tgagccgata 181981 aaagagtata tcatcatttc aatcgaagat gattgcggga gcagaaccat gcaaagcgta 182041 atgataaacg ctgaaccatc tgaaacaccc ataatggatg gcgaagctaa ataattgcgc 182101 gtaatgccct gcataagcgc tccagaaaca gcaagggctg cccctatgag cagagcgccg 182161 gcagcccttg gaatccggga atgccatata atttgatggt ctgtgtttcc cggatcgaaa 182221 tgaataagag atgtaaaaac aatatctgtg ctgagatgct ttgccccata aaggattgaa 182281 agcaaaagtg acagcgctat agcaaatgga gaagtaatca atatgatacg tgtccactgt 182341 tttgaataca tacaaaaacc tactctgaat tagttttgtg tcaatttttc agcagccgct 182401 ttcaggaaac ggactttgct ccaagctgtg ccgccttgtg cgagagggtc cactgagttg 182461 acatacacat ggtcttcttt gactgcttta aggcttttcc agattggatt tttctctaaa 182521 tcttttaagg catcaggttt gtctgcattt tcatcatcag aaaattggac gaaaatatgg 182581 tccgggttca tttcacttaa tttttctaat gaactcagct cttgcgcttt tgcagccttt 182641 acttcgttcg gcgccttaag gcctaaatca ccgtatagtg tggagttgaa atacacctgt 182701 tcagggtaaa tgtaaatgtt gccttgtctg attctgatga caagcgcttt tgaatctttc 182761 gctttatcgt tgatttttgt ttttatttct tttagatcct gttcatagtc tgcaataatt 182821 ttctttgctt ttttctcttt tccagtcagc tgggcaagaa gcatcatgtt ttccttccag 182881 tttgaagaga tatgagaaac tgggatcgtc gtgcctgctg tgctgatttt ttgcagcgtt 182941 ttttccggaa actttgttga agcaaggata acatctggct tcatttcaag aatcttttca 183001 atatttggct ccattttttc tccggttggt tcggctttat cagtgatgtc tttgaacata 183061 tcagggaatt tgccggagaa tgaaattgcg ccttgcggat gaacgtcaag caatttcgcg 183121 tcttccattg attcaacgct tcccgtaatg gcaattttgt ctgtcggtac agttacttca 183181 tatgttttat caaggtattc aattttcttc ttctcagatg ctgtgccgct tgccttgctg 183241 gcagttgatt catttttgct gccgcaagct gccgccgtca gcgcgagaag taagattaat 183301 aaggtaagag atatcttttt catctataga gcctcctgtt caattgataa ctattatcaa 183361 ttggaattat agagaatgaa cagatataac accatggaca aattcctgat ttatcatgga 183421 caatctccgg atagtaaaga aacagtttgc tgaacgatgc gttcgtgccc gcaagctgag 183481 tattcattcc acgggtcaag ggatagaaga taaacacggt tatctcgtac cgcgcttagg 183541 ttttgccatg cttctgtctg ctgtaattgc tggtagtaag ctatggtctc cggctcttta 183601 aaaagaaaaa gcatcataca gtcagcttgg taatttgcga tattttctaa cgaaatcgct 183661 tgttctgaag gtgtgtcagc cgttgttgcc gagctgaatc ctaaatcccc aaagaaaact 183721 tcgcggacac ttcggttatg agccagatag aagttttgct tatgcagcct caaaaagaga 183781 aaacgcagcc cttgaacgtg ctgaagtgtt tttttggcgg ccgttgtctg ctggtcataa 183841 tccgctagcc acttttctgc ttcggactcc tcctttaaaa atgaggcagt ttgcagaaag 183901 tgggttctcc agctttcttc tgaaggaagg tacatgactt ctgcgatgcg attcaggcga 183961 tcttgttctt ctggagaaat agaatccatg ctgacaatca catctggttc tgcctgtgat 184021 aacgtgtaca ggttttcttc ccacttttca ttaaaccggt atgcactgag ctggacgggt 184081 atatctgtcg aataatgctg atagtagtaa gacgtccatt tcggatgcag agcggccgca 184141 aaaggtatgt ggtgaagagg gatgagatgg cccattgtgc cccttccgta tgcggcgatt 184201 ttctttcggc gttttttcat atagcttgta ggtgaacagc ctgtatattt tttaaagatt 184261 ctgctgaaat aaaattcatc ttgataaccg gtttggtgtg cgatttcttt caatttgcag 184321 tttgattttg ccatgagccg ttttgccttt gtgattcgtg ttttcgtaat aaattctgtt 184381 acgctctgtc ctgtccattt tttaaagctt tcactgtagt gtttggcact gattcctgcc 184441 atttgcgaca gctgggcaag cgtgattttt gtatcggcat gggtttcgat atagtgtttt 184501 gttttttcga ttgctgaatg tgtatccgtt tgatcagata aactggcagt aaaaagatca 184561 taaatcaggc tttgtacttc aatcacacat tttagctgag aaagctgaga cgattcattc 184621 catagtgcgg caagctcttg aagccggact gcaagatttt cgatatgtga aacattcata 184681 agcttcagtt tggctaattc cgattctgtg cacggtgtga aaatatcttg cccggtttcc 184741 ttgatatagc ttagaagcct gattatacag gcatctatat gtccatcggc tgctggcgta 184801 aagccaaagg tctcgttagg cggacaaaca taaagtgtct ttttttgcag aggattggtg 184861 tttgttccga tcgaaatata gccgtttcct tttaaatgaa aaatcagcac gaatgaatcg 184921 gctaattgct gttctgagaa gagatcactt gtctttttta gatattcaat ttgtactggt 184981 tgataaatca ctgcattttg cacgagtaga ccaccttttc agaagctttc aattgataat 185041 cattttcaat aaaaattgta ccaaataaat gaaagttttc ctatataaag cgggtgggtt 185101 tttagcatga aaaaaaccct tacttatgtg taaaagtaag ggtctttcgt tcaataagaa 185161 tatgttacac gtgtaacata cgatgcttat gttctaataa atgagatact tttttcttgt 185221 tttgctgaat tgttggagtg ttttttcata gctgtttatg atgttctcaa ccgaagttcc 185281 attttcaatt tttgtcctga tccagccgtt gcctgccagt ttatcgaatg aacctgttga 185341 caggaactca aaatcctcag gatagagatc gtgtatggtt ttaatgactg aaagacccgt 185401 tttaacggct tcaaacttat ctctgtctgt cacatagagc tgcacaccgt ggcaaagcgt 185461 tccttgatgt ttagaaaacg tcggtgtgaa ggatgctgcc ctaaatgtaa cgcccggcaa 185521 atggaggctg tttaatgttt cttcaagttc tgtgcttttg ataaagggag ctccgatcaa 185581 ttcgaatggc tttgttgtcc ctcgcccttc ggatatattt gttccttcaa tcagcccggt 185641 tgcaggataa acaaatgtgc tttccaccgt cggcatgtta ggcgaaggga ggacgaaagg 185701 caatcgggta tcgtcaaaat ccatttttcg tttccagtgt ttcattttta ccactgtaag 185761 atcggcatca atactaaatt ctttgttgaa cagtgaagcc aattcgccta tcgtcatccc 185821 atgcttcaat ggaatgggat acaatccgac aaatgaggcg tattcaggtt ctaagattgg 185881 tccttcaata tgattcccgc cttgaggatt cggacggtcc agcaccataa atggaatgcc 185941 gttttcttta gcggcttcca ttgcgtatgc cattgtataa atgtacgtgt agaaacgggt 186001 cccgacatcc tgaatgtcaa acattagaat atcgacattt ttaagcattt ctggagtcgg 186061 ttttttcgtt tttccgtaga ggctgtatac gggaaccccg gttttttcgt caatgtaaga 186121 gcctacttcg tctccagcct gggcgtcacc gcggacgccg tgttcagggc cgaataaagc 186181 tgtcagtttg atatccgggt tctcgtaaag gatatcgaca ctgcttttta gagatgtgtt 186241 tactccggct ggattggtga tcagtccgat gcgttttccc ttgagctgtt ttttatagtc 186301 tggcaagagc gtgtctatcc cagtctggac tttaggtttt ttagctgttt gattctttga 186361 atcgggtgaa gcagaggcag cggttatcgt tccgaacatc atgagccctg tcagaaaagc 186421 gaatattgtt tttctcatgt gtccctcctt attaaagcgg tcttcccgtt ttgatattta 186481 atccgtagcc aagtgggtaa agggtgttcc ctggtttcgt gactgacgga atgtcaactg 186541 gaagtgtgcc tttaggtttt gcctggccga atatcgccat cactccggcc ggaatattag 186601 gttgaagata acggccattt gcgtatcctt taaagccata gactgcaatc agtgcttttg 186661 cttcttcgaa attggctgcg tcataggggt tgcgcaggct cattaagaca aatggtttgt 186721 tgtgctgcag tgcggctttc atgacagctc tcggaaacac ggtggcccat ttgcttgaat 186781 ctgatattgt gtcgtcgatg acaccgtcgt tgacgacagg gtcatttttg acgacatagg 186841 agccggtaat gatataatca gcctctttta cttgtttttc atgctcggtc ttaaatactt 186901 ggctggcaaa gttcattttg ctgagggata cgggtttgat tttctttcgc ttgatgagat 186961 cgtgaatggt ttgttcgatt gaagcagttt gttcttcgta aggtgccaca attaagattc 187021 ggctgccttt tttaggcttg aacggcaaag tgtgctgttc attttttaat acagttactg 187081 ctttttcagc taattttttc tctgctttca ggtgctgctt gcttcctacg atttttttgg 187141 ctttggctat tttttctttt gtactgtcgc tgtttcgcgc tggatacatg ccgcgtttta 187201 ttttcaggga aatgattctt tcaactgaat tgttgatttg ttgttcagga atatccccgt 187261 ttttcacggc ttctttcaaa gcttgaataa cacgtgcgaa tttctgttct tctttcaatg 187321 aagtgactga ggctggcatt aatgcaatat cgacaccagc ttttacggcc atgaccacag 187381 cctcttcctg tccgaaatga tctgcgattg ccttcatatt gagcgcatcg gtaacgatga 187441 ccccattaaa gcccatttcc tgacgaagaa gacctgtcat cacttttttt gaaagtgtag 187501 ctggaaccag aatgtccgat ccatcgagtt tgcttttgta agtggtgtca tcaaaggcgg 187561 gaaactgaac atgggctgtc atcaccatat cagcaccagc atcaattgct ttttgaaaag 187621 gataaagctc gacctcacga agccgttctt ggccatggga aacgagcggc agtccataat 187681 ggctgtcaac gtccgtgtct ccatgtcccg ggaaatgttt gagggcagac gcgatatcct 187741 gccgctgcaa ccctttcatc gtatataaac cgaggcgtga tgtcagttct cgattggagc 187801 tgaatgaccg tacgccgatt acaggattat caggattatt gttaatgtcc acgacagggc 187861 tgaaatctgt attgatgcct aaggcagaga gctcttttcc gatgatgctg ccggtctgat 187921 acgcattgat tctgcttctg gctgcgccca gcgccatatt ccctgggaaa ttagtgccct 187981 cccctaacct cgttacaatg ccgccttcct gatcaatact cagcatgagc gggatttttg 188041 gacttgcctt ttggtaatcg tctgtcagtt ggacagtttg ttttgttgtt tttacatttt 188101 ctgcaaaaag gatgatgcct ccgaattgat atttcttgac gaggctggcg acttcatcat 188161 tcatttttgt aagggcttgc ggagaggact cgccttcctt ttgccaattt ctaaaatcag 188221 gcatcagcat ctggccgagt ttttcatcta acgacatacg attgacaatc tgattggcat 188281 cgattgcacg tttggatgca gaggcttctg tctgtctggc cccgaaaaag catgaaagaa 188341 agagaacggc tgaaaggata agcggaaaga caggtctcat agaaacttcc tcctatcgtc 188401 taatcattca ctccatcgct tcataaatcg cggttatgac acttccataa ctgcctgttg 188461 gaaattggtc accttcaaag acgttcggat tttcttccgg atcaataact ggtgtatgct 188521 ttttatttgt taacaatgcg atgcctaaat tgtatgctgg atcaataatt gtaactgtcc 188581 ccgtccagcc ggtatgcccg taagcatttt cgctggcatg agggccaaac atccattcca 188641 tgcttttact tccgttccgc ctccagccaa gagcgaatgt cggatctgtt gctgaaggtg 188701 ctgtaaacag gtcggctgtt ttctgatcaa ataaagaaat gtttcggtat gaacctttgt 188761 ttaacatgac ttgcagcagt atggccatat catctgcatt tgagaacaat ccggcatgcc 188821 cagacacgcc gtccattgag taaaacgctt tttcgtcatg cacctctcct tgcagcgtgt 188881 ttgtgcggat gttagggaat tgaataacgc cgtcacgtgt attgcccatg cgttcagtag 188941 ctgcgaactg tttcggttta aagccctttt gcagcggatt gtacaaggta tgcttcagcc 189001 tgagcggttt gtagagctct tgctccgtgt agacatcaag cggtttgccg gtgagttttt 189061 cgacaataca tccgagtagc atatatccaa tgtcactgta tacgtgtttt gtcccggttt 189121 gataatcgag cggaattttc gtcaaatatt caatcgtttt gtcccgttct tgggaatagt 189181 acttgccggc tttttccggc gtgtaaaagt aaaagcttga tgggagccct gattggtgct 189241 ggaggacatc aatgacacgt atcttgtctt ttccttttat gaggtcaccc ggctgatcct 189301 tgaaacccgg caaatatgca gaaacttttt catagacgtc aagttttcct tggctgacta 189361 agcgctgcaa tgcaaaattt gttgcgtaca tttttgtatt tgaggctaag tcaaacatcg 189421 tgcgggtttt cattttggcc ggacggcgca gcagttctga tccttcgtac tttttactgt 189481 agccgtatgc tgcttttttt atgatgcgtc catccttcac caccacaaga acggcgcctg 189541 gaaatcctgc tgcaatatcc cgttctatca tctgatctac cttccttagc ttcttcgtcg 189601 agaattgtgc agtttctgca tttatgattt tcggctcaat caagttgcct gctgtttgtg 189661 cgaaggtttc atttggcgca aatatcgata gggttaaaat ggcactgaat atgaacagtg 189721 tctttgtttt cacaggctag cccctttctg tgcttctatc ccgtttacta tccctaaaac 189781 agaaacaatt taatcgaact gagaagccat ttcatcttta tatccgaatg cataggtcaa 189841 taaaaaaccg gccgcgtagg aaataaagag cccaacgata tacaggatga tttgcgaagg 189901 caggactaga aaagatagcg gcagtccgga gacaccaatc gcaatggtgg ctacttgaaa 189961 ataagcttga aaggcgccgc cgattccagc tcctaaacat gctgttaaaa acggacggcc 190021 aagcggcagc gtgactccga aaataagcgg ttcaccaatg ccgagcagtc ccgatggaag 190081 cccgccggcg attgctttcc tcagtgttgt ttttttcgtc ttcacgaaaa cggcaaaggc 190141 cgcgcctacc tgtcctgcac ctcccatagc caaaataggg agcagaggat cattgccaat 190201 tgaattgatc agttccatgt gcacaggcgt caagccttga tgcagtccgg ttacgacgag 190261 aggaaggaag gttgcgccca gaataaagcc cgcagcgatg ccgccgatgt ccaggatgga 190321 cagtaggccg gatgtaatag catcagaaat gaatccgcct aaaggcataa atacgacata 190381 cgttacgatt ccggtgatta acagtgaaac ggtgggtgtg acaatgatat caagtgattg 190441 aggaataaaa cggcgaataa attgttcggt gtaagcaatg aatatggctg cgaaaaggac 190501 gccgatcaga cctcccctgc ccgggagaag ctcttctcca aataaactga tttttgcgat 190561 ctccggattg ataatcaaga tcccggccaa agccccaagt gcgggtgtcc cgccaaattc 190621 tttcgaagcg ttaataccga cgagaatgcc gagataagtg aacagccctg atccgatgac 190681 tgtcaggata atcgcaattt gtgagtctgc agagagccag cctgcttgaa taattgcttt 190741 ggtaatccca gtaattaaac cggaagcgac tagagcggga ataagaggga taaaaatgct 190801 ggcaatttta cgtaagaaaa gtttaaaagg agtggcattt ttccgattga tatcggcttt 190861 ctttttggcc gctgcttctt tgacatcggc accttcttct gctgacacga gctttgagaa 190921 agcagctgta acatgattga caactcctgt gccgaggata atttgtaagg tttcagcttc 190981 aacgaccccc aatacgccgt caagctttct taaagcctga gcatccgctt tgctttcatc 191041 gtaaggcgta atgcgcaggc gtgtcatgca atgcgtatat gaagaaatat tggattttcc 191101 tccgcatagc tcaaggattt tctgtgcgag atgatggtag ttattttctt tgctcattaa 191161 aacccctccc cttcaagatg ccttatttta ttctcataga ttgtatggct gctctcgttt 191221 tatctatata accggttgtc gtttcatact gctcagccgc catgcctaaa aacaaaacat 191281 caattataaa aagctgggcg aggcgggaag aagtggctgc acttcgaatc aaggcttcat 191341 tggaatgggc tgtatacaaa gggacatcag ccagtgcgga gacggatgtc tgactgaatt 191401 gtgtgaggct gatcgttgtg atgccttttt ccttagccat ggcgaacagt tcaacgattt 191461 cctgtgtctc tcctgaaaac gaaatggcga atacgatgtc gtctttatct gcatttgcga 191521 ttaaagatgc cacaagatga gtgtctgtaa acgcggttgc ttgtttatga atgcgaagcc 191581 acttttgctg ggcgtccttg gcgacaatgc cggaagcccc gaggccgata aaatgcacgg 191641 tatgagcttt gagaagcaga gaaaccgctc gttcaagctc tttgtagtcc atcaggtctg 191701 aagtatcctg aatggcttga atggcattgc cggccgtttt ttcggaaatg gagggcagcg 191761 gctcgtgggg aacaatatcc cggtagccct gaaacgtagg ctttgccaga tcgcctgcta 191821 ctctcatttt taaatcttga aatcctttta aaccgagtga tttgcagagc ctgatgacgg 191881 cagcgtcact tgaattggct aaggcgctga tttcgttgac cgtgctttcg attgctttgt 191941 ggggatgggc taggatataa tctgcaagtt tgcgctcgga tggagggagc ttatgcttca 192001 ttgattggat gatcgctaaa ccgcctgtgg ccattctagt tctctcctta tcatggatgg 192061 taatgttcga ttgctttgtc aatgaaaccg tttgcttcat cgagtaatgt ctgtgcttgt 192121 ttctgatctg tgcttgtttt gagcatgacg attgctgttt tgacgtgatg atcggcttgt 192181 tccagagtgt atctggctgt gtcgtatgaa gcgtttgtaa ggctttggat gatgctgatg 192241 gcgcgttctt ttagtttttt gttgctgacg ttgacgtcta ccatcaagtt ttcgtaaacc 192301 ttgccgattt tgaccattac agcggtagat atcatgttta gaatcatttt atgagcggtt 192361 gcggctttca tacgtgttga tcctgtaatg gcctcaggtc cgacgacaac ctcaatgctg 192421 tgatccgcat ccttgctgat ggcggaattt tcattgcaag taagggcgat ggtgtgtgct 192481 ccgactttac gggcgtatct tagggcgcct gcggcgtagg gtgtgcggcc gcttgctgcg 192541 atggcaatga cggtgtcatt tgaagtgagc tgtatgtttc ttaaatcttc agctcctgct 192601 tcttcactgt cttcaatgcc ctctgctgcc tgtaaaaagg cttcggggcc tccagccatg 192661 attccgatga cctgatctgg gcttacgctg taggtgggag gacattcaac agcatccatg 192721 acgccgagtc tgccgcttgt gccggcgcct gtatatatga gccggcctcc attttgaaac 192781 gattcatatg cgcagtctac agctgttttg atgtcgggga gaacctcctg aacggctgca 192841 gcgactttca tatcttcgtt gttgatcatt ttaaggatgc cgagagtgtt tgctttgtgg 192901 atttcaactg tttgactatt gcgtgattcc gttgtaagac ggtgaaggtt taatggttct 192961 gacatgagga tgccccctgt tttaaaatga tatatctcaa tattcagtat attcatttct 193021 gttatgatat ttcaactatg tttttaaatt tttgaaattt tatttcactt aagactataa 193081 gaaatgatga aggatcaact gttctccaag cggcccgatt cttcgccgtc ctttatcaag 193141 gaacccgctt ttcatataaa ggtgttttgc gcgtatgttc agatgattga cggccaagat 193201 gatttcgtcg caccatggaa aatatccgct cacaaaagcg ggaagcaaaa gcatggcttt 193261 tttcgcatag ccttttccgt gatgcacagc ggttaaagac agggagctga gcagtaaagc 193321 aaatggattg ttagaatagg aagcaagcgt ttcttttgat gcatgtaaaa tgaaaaaacc 193381 gactggaagg tcgtctttta agatgacaac cgggtatcgg tcctgtatgc ccagagcctg 193441 agacagcacc tctttcggga gggaggtaaa gcgtttgtca tcgttggtga gcgtgaatga 193501 ttggagctcg ggcaagtgtt caggcttata gaaggataaa gaaatgtctt gagtcatggg 193561 gtggcctcct tacaatatgt cgttaagctc gttttccgaa atgacgcggt agcccgcttg 193621 ttttaacagt gcggcggtta ctccgctgcc ggtgattttt ttgccagaga atgtgccgtt 193681 atagataaaa ccgcttccgc aagatggact gttttctttt aatatgacgg cagaagcgtt 193741 gatttctttt gcgtaagcca atgttttcgc ggcgccttcc atatatagtt ctgtgacgtc 193801 ttctcctgaa gctgtcacga ttttcgctgt tccattgagg acatcctcgc cagtgcctcc 193861 tatgatttct gcgggttcgc gtggggtaga gaagccgccg agaagttcag ggcaagccat 193921 gactgctttc ttttcatcga ctagttttct gattttctcc gacgctgcgt gagagccgtt 193981 atatctgcat tcaatgcctc caaggcaaga actgactaga atcatattgg tttctcctct 194041 cttgctttgc ttgtctctat cataaaataa atggctttag ttgggaggct ttttcagtta 194101 aaaaaggagt taaaaagttt gaaaataaaa aatttaattt tcctctttac aaacaggggg 194161 tgacctgtat ataataactt ttgtcagctc gacgagaaca caacggcccg ttggtcaagc 194221 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcaccat 194281 ttggaggatt agctcagctg ggagagcatc tgccttacaa gcagagggtc ggcggttcga 194341 gcccgtcatc ctccaccatc ttgccggtgt agctcaattg gtagagcaac tgacttgtaa 194401 tcagtaggtt gggggttcaa gtcctcttgc cggcactgtt ttttcaaaat tttatgtgga 194461 ggggtagcga agtggctaaa cgcggcggac tgtaaatccg ctccctcagg gttcggcagt 194521 tcgaatctgc ccccctccac cattattggg ctatagccaa gcggtaaggc aacggacttt 194581 gactccgtca tgcgttggtt cgaatccagc tagcccagtc acagacacct ttgatcaaaa 194641 ggtgtctttt ttcttttcgg aaaaatcatt ccaacttcta actgttcagt ctgtataata 194701 attttaaaaa tatgttaagg tagtttattc acgaattacc atctacaccc tgccaaaaat 194761 ttgataaact tattttataa aaaaattgaa accttttgaa acgaagctcg tatacataca 194821 gaccggtgaa ggcagaggtt agataaatat ggaaatgatg attaaaaaaa gaattaaaca 194881 agtcaaaaaa ggcgaccagg atgcatttgc ggacatcgta gatatttaca aagataaaat 194941 ttatcagctt tgctaccgta tgcttggcaa tgtgcatgag gcggaggata ttgcacagga 195001 agctttcatc agagcgtacg ttaatatcga cagttttgat attaaccgga aattttcaac 195061 ttggctttat cgaatcgcga ccaatttgac cattgaccgc attcgcaaaa agaagccgga 195121 ttattacctc gacgcagagg tggctggtac ggaaggcttg accatgtatt ctcaaatcgt 195181 cgcagatggt gttttgcctg aagatgcagt tgtatcgctg gagctctcaa acacgataca 195241 gcagaaaatt ttaaagcttc ctgacaaata cagaacagtc atcgtattaa agtatattga 195301 cgaactctca ttaattgaaa tcggggagat tctaaacatt cctgtgggga ctgtgaaaac 195361 gcggattcac agaggcagag aggctcttag aaaacaatta agggatcttt aagtggggtg 195421 atgaaatgag ctgtcctgaa caaattgtgc agcttatgca tatgcatctt gatggagata 195481 tccttccaaa agatgaacac gtattaaatg aacatctgga gacatgcgag aaatgcagaa 195541 agcattttta cgagatggag aaatccatag cgctcgtacg gagcacatcg catgtcgaag 195601 cccccgcgga ttttaccgct aatgtcatgg caaaattgcc taaggagaag aaaagagctt 195661 ctgtaaaaag atggttcaga acccatcccg ttatcgcagc tgctgcggta ttcatcattt 195721 tgatgggcgg gggttttttt aacagctggc ataatgacca caatttcagc gtgtccaagc 195781 agccgaatct tgtggttcat aaccatactg tgaccgtgcc agaaggtgag acggtcaaag 195841 gtgatgtcac tgtcaaaaac ggcaagctga ttattaaagg caaaatagac ggggatgtaa 195901 ccgtcgtaaa cggcgaaaag tatatggcct ctgctggaca agtcaccggt cagattgaag 195961 aaatcaatca gttattcgac tggacatggt acaagatgaa gtctgcgggg aaaagtgtac 196021 tcgatgcatt caatccgaac ggagaagagt aaagcgcgtt agccgctttg ctcttttttt 196081 gcgggctgag agggctggca catttcactt gctaaatcga aatgtggtat aatgggctcg 196141 ctatgtaaag tacatatgcg taacacgtaa aacacaaaat acgaaatgac tgaaatcttg 196201 gaggacgagg aaatggcttt tgaggatatc ccttttttgc agtacctcgg caatgccgtt 196261 gatattctcc ttgtttggta tgtgatatat aaattgatta tggtgatacg cggcacgaaa 196321 gcggttcagc tgttaaaagg aattgtagtc atcgtgcttg ttcgtatggc cagccaatat 196381 ttgggcctca gcacacttca atggctgatg gaccaagcga taacatgggg atttttagca 196441 attattatta tttttcagcc tgagctgaga agagcgcttg aacagctagg ccgcggccgc 196501 tttttttcga ggagcggcac gcctgttgaa gaagcgcagc agaaaacgat tgaggccatt 196561 acaaaagcaa tcaattatat ggcgaaacgc cgtataggcg ccctgctgac cattgagcgg 196621 gatactggaa tgggcgatta tattgagacc ggcataccac taaatgccaa agtcagctct 196681 gagctgctga tcaatatttt tattccaaac accccgcttc atgacggtgc ggtaattatg 196741 aaaaataatg aaattgccgc ggccgcctgt tatctgccgc tttctgagag cccgtttatt 196801 tcaaaagaac tgggcacgcg gcacagagca gctgtcggta tcagtgaagt aacagacagt 196861 ttgacgatta ttgtgtctga agagaccggc ggcgtcagtg tggcaaagaa cggcgacctt 196921 cacagagagc ttacagaaga agcgctgaaa gaaatgcttg aagccgagtt taagaaaaac 196981 accagagaca cttcttctaa ccgctggtat tggaggggca agaaaaatgg ataaattctt 197041 aaacaaccgc tgggctgtga aaattattgc tctgcttttc gcgctcttgc tttatgtggc 197101 ggttaacagc aaccaagcac cgactccaaa aaaaccgggt gaatctttct ttccgacatc 197161 aacaactgat gaagcaactc tgactgatat tccggttaaa gcgtattatg atgatgaaaa 197221 ttacgtcgtg acgggtgttc cgcaaacggt taatgtcacg ataaaaggct cgacaagcgc 197281 cgtgaaaaag gctcggcaga ccaaaaactt tgaaatatat gccgatatgg aacatttgaa 197341 aaccggcaca cataaggttg agcttaaggc caaaaacgtg tcggatgggc tgacaatctc 197401 aattaatccg tctgttacga cagtgaccat tcaggaacgg acgaccaaaa gttttcccgt 197461 agaagtggag tactacaaca aaagcaagat gaaaaaaggc tattctccgg agcagccgat 197521 tgtcagtccg aaaaatgtgc agattaccgg atcgaaaaat gtgatcgata atatttctct 197581 tgtaaaagct tcagtgaatt tggaaaacgc agatgaaacg attgaaaagg aagcgaaagt 197641 gactgtctat gataaagacg gaaacgcgct tcctgtcgac gtggagccct cggtcatcaa 197701 gattaccgtt ccggtgacaa gcccgagtaa aaaagtgccc tttaaaattg aacggacagg 197761 aagccttcct gacggtgtca gcatagcgaa tattgaatcc agccccagtg aggtaacggt 197821 ttacggctca caggatgtgt tggattctct tgaatttatt gacggcgtca gcctagattt 197881 aagtaaaatt aacaaggatt ccgatatcga ggcagatatt ccgcttcctg acggtgtcaa 197941 aaaaatctca ccgtcaaagg tgactttgca tatagaagtc gatagtgaag cggatcagaa 198001 gttcgagaat gtccctatca agactgtagg gctgagcagc tcacaaaaca ttgaatttct 198061 tgatcctgaa tcacaagcga tagatgtaac ggctaaaggc tctcccacga atataaataa 198121 actgaaaaaa tcagatattg aattgtatgt gaatgtttca gatttagagg acggggagca 198181 tagcgtgaag cttgaagtga acgggccaca gaatgtaact tggtccttgg ggcggaaaaa 198241 cgccaaaatc aagctgacgt ctaagaaaag caatacatca acgaatgata acagcagcaa 198301 tacatcaggg aaccaggaca cagataaaca aacaaatgat caaaagaaca atcagcaaga 198361 agatacaaag aacactgata aaaacaacaa cgatcaaaac caagacggaa ataaagatca 198421 aaaccaagat caggatgagg atgaatccac tgcgaattca caatcctcat cggaataaaa 198481 aaggagcgat tataaaatgg gcaagtattt tggaacagac ggtgtaagag gtgtcgccaa 198541 tagtgagctt acacctgagc tggcctttaa agtcggacgt ttcggcggtt atgtgctgac 198601 aaaagacaaa caacgtccaa aagtgctgat aggccgcgat acacgcatct ccggccatat 198661 gctggaggga gcccttgtcg ccggactttt atccattggc gcagaagtca tgcgcctggg 198721 tgtcatttct acaccaggtg tatcttattt gacaaaagcg atggatgcag aggcgggcgt 198781 catgatttcc gcttctcata acccagtgca ggataacggc atcaaattct ttgggggaga 198841 tggatttaag ctttctgatg aacaggaggc tgaaattgag cgcctgatgg acgaacctga 198901 ggataagctg ccaagacctg tcggagcaga ccttggactt gtaaacgatt attttgaagg 198961 cggacaaaaa tatctgcaat tcttaaaaca gacagctgat gaagatttca caggcattca 199021 tgtggcattg gactgtgcca atggcgcaac gtcatccttg gcgacacacc tgtttgctga 199081 tttagatgca gatgtttcta caatggggac ttccccgaac ggattaaaca ttaatgacgg 199141 cgtcggttcg actcatcccg aagcgctcag cgcgtttgtc aaagagaaaa acgcggatct 199201 cggtcttgcg ttcgacggtg acggcgaccg cctgattgct gtcgatgaaa aaggaaatat 199261 tgtagacggc gaccaaatca tgtacatatg ctcaaaacat ctgaaatcag agggccgttt 199321 aaaggatgat acagtggttt caaccgtgat gagcaacctc ggcttctata aggcgctcga 199381 aaaagaaggc atcaaaagcg tgcagacagc tgtcggcgac cgctacgtag tagaagcaat 199441 gaaaaaagac ggctacaacg tcggcggaga gcagtcagga catcttattt tccttgatta 199501 caacacgaca ggggacggat tattgtctgc tattatgctg atgaacactt taaaagcaac 199561 aggcaagccg ctgtcagagc ttgcagctga aatgcagaag ttcccgcagc tgttagtcaa 199621 tgtgagagtg actgataaat ataaagttga agaaaatgaa aaagtaaaag cagttatttc 199681 tgaagttgaa aaagaaatga acggcgacgg ccggattttg gtgcgccctt caggaactga 199741 accgctcgtc cgtgtcatgg ctgaagcgaa gacgaaagag ctgtgcgatg agtatgtcaa 199801 tcgcattgtt gaagtcgtcc ggtcagaaat gggattagag taacgaagtc tattatcaga 199861 gagtgaacaa gacaagcgag gtttacataa gataattgtg agacatacgg caaagttgct 199921 taaaaaacaa ttgaccgttt atgccacatg ttgtaaaatc aagcttgtct tgttcttatt 199981 ttctcaatag gaaaagaaga cgggattatt gctttaccta taattatagc gcccgaacta 200041 agcgcccgga aaaaggctta gttgacgagg atggaggtta tcgaattttc ggcggatgcc 200101 tcccggctga gtgtgcagat cacagccgta aggatttctt caaaccaagg gggtgactcc 200161 ttgaacaaag agaaatcaca tgatcttcca aaaaacatgt aggaggggac gattgaaagt 200221 ccccttgaaa tttgactttc ttcgtctcct tttacaatct taggaggaag aaaaatatgt 200281 gtggaatcgt aggttatatc ggtcagcttg atgcgaagga aattttatta aaagggttag 200341 agaagcttga gtatcgcggt tatgactctg ctggtattgc tgttgccaac gaacagggaa 200401 tccatgtgtt caaagaaaaa ggacgcattg cagatcttcg tgaagttgtg gatgccaatg 200461 tagaagcgaa agccggaatt gggcatactc gctgggcgac acacggcgaa ccaagctatc 200521 tgaacgctca cccgcatcaa agcgcactgg gccgctttac acttgttcac aacggcgtga 200581 tcgagaacta tgttcagctg aagcaagagt atttgcaaga tgtagagctc aaaagtgaca 200641 ccgatacaga agtagtcgtt caagtaatcg agcaattcgt caatggagga cttgagacag 200701 aagaagcgtt ccgcaaaaca cttacactgt taaaaggctc ttatgcaatt gctttattcg 200761 ataacgacaa cagagaaacg atttttgtag cgaaaaacaa aagccctcta ttagtaggtc 200821 ttggagatac attcaacgtc gtagcatctg atgcgatggc gatgcttcaa gtaaccaacg 200881 aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgatgaccaa gttgtcatca 200941 aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt gatgccagtg 201001 atatcgaaaa aggcacgtac cctcactaca tgttgaaaga aacggatgag cagcctgttg 201061 ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtct gtgcctggcg 201121 atatcgctgc cgctgtagcg gaagcggacc gcatctatat cattggctgc ggaacaagct 201181 accatgcagg acttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg ccggttgaag 201241 tgcatgtagc gagtgaattc tcctacaaca tgccgcttct gtctaagaaa ccgctcttca 201301 ttttcctttc tcaaagcgga gaaacagcag acagccgcgc ggtactcgtt caagtcaaag 201361 cgctcggaca caaagccctg acaatcacaa acgtacctgg atcaacgctt tctcgtgaag 201421 ctgactatac attgctgctt catgcaggcc ctgagatcgc tgttgcgtca acgaaagcat 201481 acactgcaca aatcgcagtt ctggcggttc ttgcttctgt ggctgctgac aaaaatggca 201541 tcaatatcgg atttgacctc gtcaaagaac tcggtatcgc tgcaaacgca atggaagctc 201601 tatgcgacca gaaagacgaa atggaaatga tcgctcgtga atacctgact gtatccagaa 201661 atgctttctt catcggacgc ggccttgact acttcgtatg tgtcgaaggc gcactgaagc 201721 tgaaagagat ttcttacatc caggcagaag gttttgccgg cggtgagcta aagcacggaa 201781 cgattgcctt gatcgaacaa ggaacaccag tattcgcact ggcaactcaa gagcatgtaa 201841 acctaagcat ccgcggaaac gtcaaagaag ttgctgctcg cggagcaaac acatgcatca 201901 tctcactgaa aggcctagac gatgcggatg acagattcgt attgccggaa gtaaacccag 201961 cgcttgctcc gttggtatct gttgttccat tgcagctgat cgcttactat gctgcactgc 202021 atcgcggctg tgatgtggat aaacctcgta accttgcgaa gagtgttact gtggagtaat 202081 aaatgtttaa cccctttgga taagattatc taaaggggtg tttttatgtc caaaagcgaa 202141 agaacgtcta cagtggaaaa atggattaaa gaagttgatg gtacaggacc cgactatcga 202201 tcgaccatgg ctatagattt aagatgtttc ctcattagat cggtcaatca ggttaaaagg 202261 cattaaaact tggagagaaa ctgcttttgc ctaactgagt tttctaatgt taatacagat 202321 ataagagagc agttcctcat taagatacgc ttttgatagc agttggaatt tagcatgcta 202381 gaaatccgaa aaccggagag cctattggaa tgataacgtg tttttttatt gacaattaat 202441 aaagggcaaa gaattctaga agtcgcactt acaatgtact tgtgggatta ggttttaaag 202501 ttcattcttt ttttattgag tacattccgg ttaaagttga aatgattcag taaaggacac 202561 gccataaata aaaggtagcg tatgattgcc attctttcca tggaaccgat atttctaaga 202621 tttcatcttt cgtaggcttt cggttcatat tacgtaatat ttttatcgaa tgaataagac 202681 ccacatcatc gattggaaaa gctgtcggga acctaaggca gcgcattaga acataattgg 202741 ctgtccaagg accgattcct cgtattttaa ttaagttttt ttcagcatct ttaaagttca 202801 ttttcattaa tttttccctc gataattctc cacttgccat taatctggct attccaatga 202861 tatattcact ttttttcacc gtcattttaa tatctgccag gtcggtaggg gttaaccgtg 202921 caattcgctc gtacggtggg aacacccaat actttttacc attccattca atagaatcgc 202981 caaatgcttc tacaaattgc ttctttaagg agtacgcgaa ggctaagtta atttgttgcc 203041 ctaaaactcc ccaacataaa gcttcaaata aatcgggaat gccgatcact cgcaacccat 203101 aaaattttcg ggcaggcatt ttaagtaatg gatctgcttt tgccatttca taaaatggag 203161 ttaaatcgtt atcaagatca aaccattcat gaatatattt tacaatctct tcccgtttcc 203221 actgctcaac aggtctagaa tcgtttagga attgaacaat catttgttta ttattgatta 203281 cgcttacctg cactaaggac cgaatttccc caatggctat aacttttgta atgatattgt 203341 tctctatttc atacatgcat tcattttttt ccctggttag gtagccaagg ttcgcattca 203401 tgtcgaaaat ttcaggtaat gtaatgacaa taacatcatt gacttcatgc catgtcactt 203461 tttcattctc cttatcttaa ataattataa gaaaactcac gctggttgaa attagtttat 203521 cacataatca tctttactca ttttgttatc ttgctattac attctaacca ccttattttt 203581 ttctatttat gaggttatag tgtagttatc aagaatgcta aacgggagta gataaaaatg 203641 gcccaagata taaaaaacgc gtgtcgaaaa tttaaattgg gattcaattc aaagaattag 203701 atgagcattg taaggagagg tgagataaat gccggatagt atcaataacg gacataaaga 203761 gagccatgat catagaattt cgaatgatgc agaaatgata acagatgaaa agtggcaagc 203821 aattataaat aatgatgcag cgtacaataa tcaatttttc tacgctgtta aatcgacagg 203881 gatattctgt aaaccatcct gtaaatctcg cgttccgaaa aaagaaaatg tatgtatctt 203941 tccaaacaca gaacaagctc tccgcgcaaa ttttcgccct tgtaaacgtt gcaagcccac 204001 taatgaaaaa atgcctgata gcgagtgggt tgatttaatt actgaataca ttgataaaaa 204061 tttcacagaa aaattaacgc tagaatcgtt agcagatatt tgtcatggga gtccgtatca 204121 tatgcatcga acatttaaaa aaattaaagg cattacgctg gttgagtata tacaacaagt 204181 tagagtacac gcggctaaaa agtatttgat tcagacaaat aaagcgattg gagatatcgc 204241 tatatgtgtg ggtatagcta acgcgcctta ttttattact ttatttaaaa agaaaactgg 204301 acagacacca gcacgatttc gtcaaatgag taaaatggag gaaacgtaca atggaaacaa 204361 ataaaccaac cctttattgg tctttactaa tgttcaagga ttggaatttt tatattgctt 204421 caactttaaa ggggcttgtg tttgtaggtt cacagaacaa accaatcgag gaattgttcg 204481 aatgggctag gaaacgcttt ccgggaagtc ttcttgttga agatgatgat aagcttgaac 204541 cctatgccgt tgaaatcact caatatctag aaggaaagcg gaaaaacttt actgttccag 204601 ttgagtacgc cggtacgcaa tttcagctag ccgtctggaa tgcactttgt gaaattcctt 204661 atggacagac gaaatcctat tccgacattg caaatgatat aaataaacca gcagctgttc 204721 gtgctgtagg tgcggctatt ggggctaatc cggtattaat tactgtaccg tgccatcgtg 204781 taataggaaa gaatggctca ttaactggct atcggggcgg atttgaaatg aagacactgc 204841 tcctcgatct ggaaaagcga gcttcatctg aaatggatgt tcctcattga aagtgaatca 204901 tctataatgg gttggattct tttagaggaa agtaaagacc agtttactga taaacttgac 204961 aacttttaaa atttagcata tcttatacgt aacttaataa tcgatgcaga tgtttatttt 205021 tccttttaaa atatgtaggc ctttagcatt cttttcatat ttcattttaa atattgatag 205081 gatgaaaaag tatcctaata aaaaaggaag agaacatgag tcgatttatt tgataatcag 205141 gactatatta aaggaaatga aaacatagca taaagtaaag accaataata aggtagctct 205201 tcaaaaaact tcgctgaagt tagttgaagt gaagccgaca attttcagga ttcaatgatc 205261 taacataatc attgaaattt tgaagttgtc ggcttttttg ttggaaaaaa atagagataa 205321 ataaaaattg aaataaataa tagacaaata tgatctgatt gaaaggtctt ttgaccaata 205381 atgagtttta aaaaagggag aatttagaat gttagtttcg ctgagtttgt catcattatt 205441 aacattattt tttattatgc ttatggcttc tgggattagt ggactattgt ttttacatcc 205501 gcgtgtaccc ttgagttttg ttcgcattca tattgggatc ttggctttac cacttttggt 205561 ttccttactg attcttgcca atagtggtgt gagtggaaat gttggccctt ggcacttaga 205621 ttccttagct tgtttaatga ctttctttgt tcttgcaatt ggattcatca ttcagcgttt 205681 ttctgtacgt tacttaatgg gggatcgatc ttatcgaaaa tattttacgc tttttacttt 205741 cacaacagga gctgcttcaa tgacatggtt aagtggtgat ctccgcttga tggttctatt 205801 ttggggagca actcttgttg gtttaacctt acttataagg ttaaacagtg cttggcaagt 205861 ggctagtgaa gcagccaaaa tttctggacg gttatttttg ttaagttggt tttctttgtt 205921 ttttgcgatg atgtggcttt ttcatgccac aggtcaatgg cagctatcat tggttgtaac 205981 aaatgaaagt ttagctgggc tgggagaatg ggagagaaca gggattcagc tattgattgt 206041 actggcggtg atcattcctg cagctcaatg gccgttccaa agatggttgg ttgagtctat 206101 tgttgctccc accccagttt ctgcaattat gcatgcaggt ttagtaaatg ctggaggaat 206161 aatactaact cgattttcac ctctatttca tggtggtatc gcttcgatta tcttacttct 206221 gcttgctagc atttctgtat tgattggaac tggaattagt ttagttcagg ttgattataa 206281 acgccagtta gtaggctcca cgattggaca aatggggttt atgctcattc agtgtgcatt 206341 aggcgcctat atagcagcca ttattcacct tattttacat ggtttattca aggctacgtt 206401 gtttctacag gctggttcag cagtagggcg tcatgaagta tcgactcgca ctaatgaaag 206461 aacatcctat ttatgggtca tggctggtcg gattttatcc ttagttatag gtgttgcttt 206521 ttggctcact gctcctggag acgggtatca cttaatcagt gcgctgatct tagggtggtc 206581 attgtccgtt tcttgggatc agcttgtcgc ttttggagag ggccgaattg gccggattgc 206641 cggtttaact gttttaggag gagcagccct cgtatatttt atcattcatc accttttcta 206701 taagtggctg catacaacca tttttcaaag tgttcaacct ccaatgtcag ctgtcatgat 206761 tgtcgtatgt ctcttactct ttggcagtgc tttaggtacg tgggttgctc gtcatcgttc 206821 ttccgttttt ttcgcggtac tctatctttg gttagtccga ttaggtgaag caaaaccaaa 206881 gtcagtagag agtcacccag actaccttaa acaatatatt tcataaggag ctaatctgag 206941 atgggcatta catccgtatt aacgaaagat aatgtaaaaa agatagatac agatattgat 207001 gttcaagaaa gggatcttaa cgttttcatt acatctgcca gccgagtgat tgcgccactt 207061 tggcctattt ctacatttgc tgcacgtaat ccgtggatgg gacttgaaaa ccaacctttt 207121 gatcaggttg caagttggtt gaaaaacact cgcgatgttg atatataccc tagtgcgtct 207181 atgatccgtt cagcaaagaa taaaggtgag attgatgaag attttgtgga aatggggctg 207241 cagcgttggc ttgattcaca ttcctatcac atcccacggg acgtagcaga gcgattttgt 207301 catgctgcat taaagttaga tcccctgcct tccgaccttt tatcatcaca tgagctggag 207361 aaattagtaa gtgaatgtag tggattggat catatcgaga atgtgtttat gcagccacta 207421 agttcgtata tagagaatca agatggtgaa aggctagtca atatactaga tcatcatgtc 207481 attaaatgga gtaaattata tcttgatgac tctcaagcgg gttggacaat gcctaatcgt 207541 gaggaaggtt tctatcgtgc ttggcagcat cttattcaat atgatccagc acttagcaaa 207601 aagcagcgag aaagggtaaa aggttggccg aaagaggcac atttggcttt acaagaagct 207661 ttattcgcac tagaaatccc agagtcagaa atccagactt atcttgaagg tcatttactt 207721 tcattacctg gatgggcagg gatgatgctt tggcgctccc aacaatcgag ccacgaacat 207781 gcactactaa cagaatattt agcggttcga atatccatgg agtgggctct tataaagcca 207841 tacttacctt tgactaatga acgatctaag aaaacaattt caattgctcc ccttatagca 207901 gcttggattc attggggtgg gcttacatta gaagaatggt cacagatgac ggccagtgaa 207961 caaaacgaat atttatcatt tgcctacagc tttgatgaga aacttcgcaa gaaactttgg 208021 ttagaagctt gggaacaaac gtacactgat cgattaagcc agaagatcat ctcgaaacaa 208081 cgtgaaaccg gccgtgaaaa atctgcatta gctcaattag cattctgcat cgatgtacga 208141 tcagaacctt ttcgtcgtca actagaaaaa gaaggcccgt ttgaaacgat tggtattgct 208201 ggtttcttcg gggtgccgat tgcaacttgt gaacttggca gtaaacacag tcatgcttcc 208261 ttgccgatca tacaaaaacc gcaaaataaa ataaaagagt tcgcagatga ggatgtattc 208321 aaaaaataca atcaacggaa gcaagcaatt cattctttaa gccatacctt taaaacgatg 208381 aagcagaatg cgctttcgag cttactactg cctgagctaa gtggaccttg gcttactctg 208441 caaatggcag cccgtagctt tgtgccaaga aaggcgggtc gtttcattcg taatctccgt 208501 gaggcttggt tacgcaaacc tgatacaaaa ctctcgcttc atcatgatgc tacagaggca 208561 gaaatacctg tgggttttac tgatgaagaa aaagtgaact atgctcgcca agcattaaaa 208621 atgatggggt taacagagaa catcgcacca ttggtcgtga tttgtgggca tggcagtcaa 208681 agtactaata atccttattc tgcagccctt gattgtggtg cctgtggtgg agcggccggt 208741 ggattcaatg caagagtttt agctgcttta tgtaatctat cagaggtacg agaagctctt 208801 ttagctgaag gaattaaaat tcctgaggat acagtttttg cagcagctga acataataca 208861 acagtagatg aattacattg gctttatgta ccagagcttt ccgaagctgc acaagaagca 208921 tttgaacaaa ttgaagccgt tatgccgaaa gtgagacatc atgtaaacgc agaacgtcta 208981 gcccaattac cgaatttcca atcgaagcta aaaaatccga aggctgaggc aaaccgattt 209041 gcggaagatt ggagtgagat acgtccggaa tggggactgg ctcgtaatgc cgcttttatt 209101 atcggtaaac gtgaattaac tcaggattgt gatttggaag gcagagcctt tctccataat 209161 tatgattgga agcaggatga aagcggtgaa ctcctagcaa atattattgt aggacctgga 209221 actgtagccc aatggattaa tttacaatat tacgcatcaa cggtagcacc tcattattat 209281 ggcagcggaa ataaagcaac tcaaaccgtt actgcaggtc tcggcgttat gcaggggaat 209341 gcaagcgatt tgttagccgg actgccttgg caatccgtca tggaatcaga tcacgaggcc 209401 tatcattctc ctcttcgttt attgatactc atccaagcac ctagagaata tgtagaacgg 209461 ttattaaatc atgattcagc atttctgcaa aaagttcaaa atggatgggt ccgactggct 209521 agtcttgatc cagaaggatg ttgggaaagc tggtaatgat gaatctaagc atttatcaaa 209581 tggatttgtt actcaataca aaaatgataa acataaggaa gaggtgtgct gtatgaatgt 209641 aaaccaaaat aaaaaagtat tatttttgac ggatattgaa aacggtttgg agcctatttt 209701 acaagaagcg actaacactt ctgcagagaa tatgttgact atacaaagct atggtgccag 209761 tatttcacat ccttatggag aaatcatgag gtctgttatt tttgcgattt accaggaaga 209821 tgttgaggag atttttgtag taggaacaaa agataagaag acttctgcag gtaatggact 209881 aactcaactt gaaacaatga aagataaaat acaaacattg gattatctgt ttcaaaattg 209941 caagcctgaa tttttaggtg gtacggtcga tgaatggcta aatgaaaata gcagtgacac 210001 cattgaaaaa agtgttgata tgattcgaca tcatccccta gtgccgtcat atgttaaagt 210061 tagaggttta ttcgttaatc ataagggtgg aaaaccctca atcgcggagg ttcctgatgt 210121 taaaacaggt caagccatgc ctgatcattg cttgtcatga tgaaatgcag gtttaacttc 210181 taaacgcacc catatatgga gaaagcagtt ctaaggagat tgtatgagcg ctaatttaac 210241 tgattttgtc acgaaaacaa tagaggaaat gaactcgttt gatcgtgaaa atatggaatg 210301 tataaaaaaa ctaattagaa aagcaattga tttttatcat ctaaagtctt atgaagaagt 210361 tgaggaaacc cattcaggaa atgttcgatt tttgcatgtc cactctatga tggaagaaaa 210421 tatgttatcc aaaatgatag tggtcacaag aaacggtaaa actgatttgg atattgaagg 210481 tgtatatgaa ggatatgttg taagagaata ttaatgagac gaaatcacaa atagaatatg 210541 ccaatttttt tgctcaggag atgtattaga tatgaaaaag tctaagggtt ctattgaatc 210601 agagatcagt aagtccatta ctcaatggga gaaggattat cttgggcggg ggtctgtatc 210661 tgttaagact gatatactgc gggacatgat catcgtcaat ttaaaaggga ttttaacacc 210721 agccgaatat gtagtttgtg gatcaaaaga gggtatgtta tctatcaaac aaactcgttc 210781 agagttagtc gaatcaggta tagaaggcct taaggatatt atcttaaaaa taaccggaga 210841 aaaagtgaaa agttttcata ctgatttaag ctcccggaca ggtgaacgag tgatggtatt 210901 taaattatgt aatgatctag agaaaaattt ggaaaagatc ttataatcta aagaaaataa 210961 atgttttgac ggtgtggaat ttgttgtgaa ttgaacataa agaactgccg attcttttgt 211021 tttacaatta tggtatcatt gataactttt attcatatcc taagcggaca taaagagatg 211081 tcaattcata gtacactgtc atgttattcc tgtcgaaaga tctaacatcc gctgttgtta 211141 tgagcggatg tttttttaca tctattttaa atacatgaat ttgatgctgg tgattagtca 211201 cttgaacaat atttgaaaac atccttgtca cctgccgggt ttccccaagt gtttagtgac 211261 atgattatga gaccaacttc gtaaagcttg ctgataaatt taagcggtga acaaaattga 211321 tatgctgtct tcagtttcat ttcacggaat tagtcagaga taaaccttta attaaatata 211381 tccaaaaaac ggattgacat atcgaaatat aacgatataa taatcgatat ggaaccaatt 211441 gaagtattca aagccttatc aaatgaatca aggctgcaaa ttttacaatg gctgaaggag 211501 cccgatcgtc attttgcacc ccatgaaggg attgatatga acacaatcgg ggtatgtgtc 211561 agtcaaataa cagacaaatt gaaaatgacg caatcgacag cttctcaata tcttaccatc 211621 cttttaagag ccggcctaat taaggcggag cgaatcggaa agtacacgta ttataaaaga 211681 gatgaagaag ccattgggaa acttgctgac tttcttaaaa cagagatata aaaataaaca 211741 tcaaaagatg tttattttta caccatacat atcgacatat tacgatgtgt ttattttttt 211801 ataataacat atcgataatt cgtgatatgt ttattaataa ttaaggagtg aatgttttat 211861 gtctaacact tggaaaattt atattttagc cattgtcagc tttttagttg gaacctcaga 211921 gtacatcatt tccggaattt tggatcaaat tgctcatact ctcgggatca ctttagctgc 211981 cgcgggccag cttattacca ttttctcact tgtatatgct ctttctacac ccgtacttat 212041 ggcgttgaca gcaagtatgg atagacgcaa attgatgatg tatgccctag gtttgtttgt 212101 gttcggtaat gtcctggctt ttgtactgcc tggttatgga tggtttattg cagcgcggat 212161 cattatggcg atgggagcag gtgtggttgt tgtcaccgca ttaacgattg ccgctaagat 212221 tgcatcggaa gggaagcagg gcagtgccat cgctacggtc gtgatgggat ttaccgcttc 212281 tttaatcatt ggtgttccgc ttggaagaat gatagcagta gcattaggct ggaagtctgt 212341 atttggagcc attgctttgt tgggattgat cgcaatggtc gttattttct ttactcttcc 212401 gtatactgaa ggggataagc ctgtgccttt gcttcaacag cttgctcttt tcaaaaaacg 212461 gaaagtggct atgggattat caatcacttt cttctggctc gggggatatt ctgttgctta 212521 cacttatttg tcaccgtatc tcttgaacat ctcaggtata aatggcaagc tgctcagcgg 212581 tgttttgctt atatttggaa ttgccagttt ggttggatcg aagtttgggg gatatagcac 212641 cgataaatgg ggagtgccct ttacactcgt tggcgggatg acgttgcata tcgtcacact 212701 gattctgctg tcacttgtta ctcattccta tatcggagtg ttggtgattc tcatattatg 212761 gtcgtttgcc gcatggtcca ccggtccgac acagcaattt cacctggcta caatagaacc 212821 ggaaatgtca ggtgttttgc ttagcatgaa tcagtcaatg atgcaattcg ccatggcggt 212881 cggcgcaggt ataggagggg tttttgtgga aaacgtatca ttggcctcga ttacctgggt 212941 tggtgcgtta ggggttatga ttgcaattat tgcatcattg ctgattttca attcgcaacc 213001 gaaacaagcg ctaaaagata tcaatcaata atttcgaaag ttctaacatc cgctcgttat 213061 acaagcgggt gtttttttta gcgtagtcag tccatgcatg agtcttccaa gggccgacat 213121 cgttctgtat gtgtcgaagg tgcactgaag ctgaatgaga tttcttaagg ctttgccgcg 213181 gcgagctgaa gtacagtacg attgccttga tcgaacactg gaaacacaag agaacgtaaa 213241 cctgaacatc cgcgtaaacg tcaaggaagt tgccacttgg ggagtaaaca cttgcatcat 213301 ctcgctgaaa ggcctagaca atgcggatga cagattcgta ttgccggaag taaacacagc 213361 gcttgctctg tttccgttgt cgattgcagc tgattgctta ctaatgctgc cctgcatctc 213421 ggttgtgatg tcgataagca gcgtaatgaa gagtgttact gtggagtaag atgtttaacc 213481 cctctggata ttttagccga aggggttttt agtatagata tttgatttaa attacaggag 213541 acttcattca tttaaccaaa gtcattgctt tcttaatcac taaagtttat ttgaaaataa 213601 tctcttgatt taatttcctc gaagagattt tttgtcaatc tattaggcat cagaattttt 213661 ataacataat ggaccgtctt tttgacgttt tgtttataga acaagaaaat attcaaaaca 213721 taagtggaaa attaggggtg agctcctgtt tttctcgaga ggatagcttg tcagcttttc 213781 tatttttaaa gggttaaaat attctattta tactaattaa tgtaattttt aggataatat 213841 acaaaatccc ccttacttcg acaattgcaa tctggtatta tcgtatcgca tgggagctat 213901 gtcaatagac tctatgcaaa aattgagagg aggtttactt atgaaaagaa accaaaaaga 213961 atgggaatct gtgagtaaaa aaggacttat gaagccggga ggtacttcga ttgtgaaagc 214021 tgctggctgc atgggctgtt gggcctcgaa gagtattgct atgacacgtg tttgtgcact 214081 tccgcatcct gctatgagag ctatttaaca tttgagaata gggagttgag cgtatttgct 214141 tatactcctt attttctctt aagggggatt ttatatgtca tatgatcgtg ttaaagattt 214201 tgatttgcca gagttagcgg ttcatttaca gcctcatggt gctgtaatga ttgatagaaa 214261 aagtatgttt tatttcagac tcagtggacg tggagcacag ttggcgtttc tgttatcaaa 214321 aaacaaaaat cttcataaaa cggcacgtat ttgggagatt atgaaaaaag aagagatgag 214381 tgctgaccaa ttaaaagaag agcttagtgc ccatccattt acggaggctt ggacggaagg 214441 gctgttagat cagcctttac acgtttcggg ttcgctagat tcatatttac ctattagttg 214501 taccttacag ttgacaaatg cttgtaattt aagctgttcg ttttgctatg ccagctcagg 214561 taaaccatat cctgaggaat tatctagtga acaatggata ttggttatgc aaaagctagc 214621 agcccatgga gttgctgata ttacgctgac cgggggtgaa gcaaagctga tcaaagggtt 214681 taaagaatta gtcgttgttg caagttcgtt gtttaccaat gtgaatgtat ttagtaatgg 214741 attgaactgg cgagatgaag aagttgaatt acttagtcac ttaggcaatg tttctgtaca 214801 gattagtatt gatggtatgg ataatacaca tgaccaatta agaggcagaa aaggcggctt 214861 taaagaaagt atgaatacca ttaaaaaatt atcagaagca aacattccag tgattgtcgc 214921 tatgaccatt aatgagtcca atgctgatga agtatcagat gtggtggagc aatgtgccaa 214981 tgcgggtgct tttatctttc gtgcaggaaa aacgttatct gttggacgtg cgacagaagg 215041 ctttaaggct ttggatattg attttgaaga aatggttcaa atacagctta gggaagcacg 215101 tcataaatgg ggagatcgcc tgaacataat tgattgggag cacgaagaga gttcgttcac 215161 aacagatttt tgtacaccag gatatcttgc ttggtatata agagcagatg gatacgtaac 215221 tccttgccaa ttagaagatt tgccgctagg gcatatttta gaagatagca tggctgacat 215281 tggttcacct gctcgtttgc ttcagttaaa atgtgaagca aaaaattgca aatgtatagg 215341 gaaaattgag ctatctgaac cggacttacc ttttcaaaaa gaagtcaagg cagggattca 215401 ggaatgaata gtctatcatt ggtgttctgg agtattttag cagttgttgg attactgtta 215461 tttattaaat tcaaaccccc aacaattgct tcactactct taagcaaaga tgaggcaaaa 215521 gaaataagca ttcaatttat aaaagagttt gttgggatag atgtagagaa ctgggatttt 215581 tattcagtat attggtatga ccacgataca gtaaataaac ttcatcactt aggcatactt 215641 aagaaaaata gaaaggtttt atatgatgtt gggttggtcg aatcatggag agtccgtttc 215701 gttcaccaga atcaatcatt tgtagttggt gtcaatgcca atcgagaaat cacttttttt 215761 tatgcggatg ttccgaaaaa aaccctttcg gggaagtttg aacaagtttc tccagagaca 215821 ctcaagcaga ggttaatggc ttcacctgat ggactttggt ctagagcaaa tatgactggt 215881 actggtaaaa aagaggagga ttttcgcgag gtcagtactt attggtacat agcggaagcg 215941 ggagatattc ggctcaaagt gactgttgaa ttacagggcg gccgaatttc ttatattggt 216001 actgaacaag aaatactaac agatcaaatg agtaaagtca ttcgagatga acaagtggaa 216061 tcgacattcg gagtatctgg tatgctgggt tcagctttag cgatgatcct tgcgattctc 216121 atccttgtat ttatggatgt gcaaacaagc ataatcttca gtcttgttct gggtttgttg 216181 attataatat gccagtcatt gacgctgaaa gaagatattc aattaacaat tgtaaatgct 216241 tatgatgcaa gaatgagtgt caaaacggtc agtttattag gtattttgtc tacacttctt 216301 acaggattat taacaggatt tgtagtattt atatgttcat tggcaggaaa tgcgcttgct 216361 ggtgattttg gatggaaaac gtttgaacaa ccaatagttc agattttcta tggaatagga 216421 gcagggctca ttagtttagg agtgacttct ctgctgttta acttattgga gaaaaagcaa 216481 tatttacgaa tttcacctga gctttctaac cgaactgtct ttctatcagg ttttaccttt 216541 aggcaaggat tgaatatgag catacaaagt tcaattggag aagaggtcat ctatcggcta 216601 ttaatgattc cagtcatttg gtggatgagt ggaaatatcc tcatctccat tattgtatct 216661 tcctttttat gggcggtgat gcaccaagta actggatatg acccaaggtg gatacgttgg 216721 ctgcatctat ttatattcgg ttgctttctg ggagttctct tcatcaaatt tggttttatt 216781 tgtgtattag tagctcattt cattcataat ttagtactcg tctgtatgcc gctgtggcag 216841 ttcaagcttc agaaacatat gcatcatgat cagccaaagc atacttcact ctaatgatta 216901 ggagaagatt tgatgcaatt gatgcaagta caaaatttaa gcaaatgcta tcgaaatggt 216961 gatggggttg aacatttgtc tttctcaatt caacgaggag aaatcgtggc gctattgggg 217021 ccaaatggag ctggaaaaac aacgacaatt cgatgtttga caggtctcta taagccggat 217081 aaaggagata tcctcattga gggttctcct ccaggagata taaatgttca aaaaaaagtc 217141 gcgcttattc ctgatcagcc atatttgtat cccgctttaa ctgctgctga acatattcag 217201 tttagggcaa gaggatatca tccaggtaaa aaagatgtaa aagaaagggt ttatcatgca 217261 ttgaaggaag tgcacttgga ggagaaagca aaccaattgt gtggtcagct gtcaagaggc 217321 caaaagcagc gggttgtcct ggcgggggcg attgttcaag acgctttgct gtatatatta 217381 gacgaaccga ctgtgggcct tgatatccca tcaaaacagt ggctctctaa ctggttaaaa 217441 actaaaaccg atcaagggtg ttcagcattt gtatcaactc atagtctaga gtttgttata 217501 gagacagcag acagggtgat attaattaga gacggcaaac tcatgcagga tttgtatgtt 217561 cctcaattcg aagaacaagc ggaatggaga aaagaagtga ttcgtcttct aggggaatgg 217621 tcagatgaat aatatcattt cttttttatg gcttcagtca aaaaggcgtt ttgtaagtca 217681 aggtcaggaa aaaaaaatgc cttttttgat catgctcctt tttgttgggg ccatcggatt 217741 tcaagtaagt tttgtttcta gatctacgac atgggatatg agtattgctg gttgggtact 217801 tacaggtgtt tttatccttt atacggcatt tggacttttt tcaaatcgat taccaagtca 217861 aatggcagat attatatggc tttatggcac tgccacatct ttttcaaaag ttgtgtatag 217921 tgttttattt ttcagcgtca cttggaaggc gttgctttgg atcatctcag ccatattcgg 217981 tgatgtatta attgtgcttc tgtctggtga tcatatcaat ttattaggcc gatccataat 218041 ttttgtaggg ctctttttta tcgctgaagt gtggttgatg tcggtctctt gtgccagaac 218101 agtgaagaaa atgaaaaggg tatacgtttt agtctttctt ctaatgttag gcatttactc 218161 catatgtctt tatcgcttct tctttctcca acattcatct gggatatggg agagcattgc 218221 ccgttttatt agtggcgttg gattagtgtt tgatacattg tcaccgttgt atgtggttgt 218281 atttattggg attatcacag tctcttttat gacaattgct tttacgagcc gtcaggtaga 218341 aatgaaggaa tcgttggtga aagaagctga attctgggag gaatttcaag aacgtcaatt 218401 tggttcaggt caaattatac agaaaccaaa aacgacttgg tggggcttgc aaggtctaaa 218461 tggcatttgg tcttttctgt ggttggaact gttgcttttt aaaaaatatt tattttttca 218521 tagcattcat acggtcatgc tcagtggcgt cttttatgtc gtcattttca tgtatccaga 218581 atggttttat cttctattct ttcttatcgt ctcggcagtc atgttaagtt cctattattc 218641 aggaattgtc agacattctc aatcaggcac ccttcattta ttccccggtg ccctttggaa 218701 aaaaatcatt attctagagc tgacgaatac agtctggttg tatattcttt actgtgtttc 218761 tattactttt atggcagttg ggaatttagt ttattggtat atatatggct tagggatata 218821 tatatggttc atgacaataa ggctttttgc ttttacccat acaaaccgaa acgatattaa 218881 gctttcattg cctcaatact acaagtcatt ttttatggca ttaggcctga gcggcatttg 218941 tttgtatgtc attcatttat tgactgctga ctggtataca ttagtggtgg tcgtctgcat 219001 agggagccta agttggtgcc tgttttatcg tttcagatag tggttatgta gagttattgt 219061 tttaaaacga ggagaggggc tcttttatga attcaaatgg tgataaattg tcgttatctg 219121 ttcagaattt agcgaataca aatgagatca caattgttca agcgataggt gagctaaaga 219181 aatcgggaaa agatgcaata ccagttttgg ttgaggcctt aaaagaggaa ggctctttgt 219241 gtaatattgc tgcagctgtt ttaggtgagt ttggggaaga cgcgagtgaa gcagcggagg 219301 agctatcatg tttattaaaa agtcatgcgg aagatacaag aatggcagcg gcgatttcat 219361 taatgagaat cgggaagccc agtctgccct ttgtcatcaa aatcgctcaa gaaagtgaag 219421 ggcaatcgtg cttttgggca tcttggtgta ttgcatggat tgatccgtct tgcattgaac 219481 ctaagatgta taaatgtcta aaatacgagc atgaacatcc ttcaggaata gttgctccgt 219541 ttgcggctga agaggcatta ggaaagctga ttgcttttca gctgaaagat aaggaggact 219601 gaaaggatga aagatgaaca aatgttgact gaatggccaa gtcatttacc atggttgaat 219661 caatcacaga atgattttac atttccaagt gacacatatc ttcttcttta tttttggtca 219721 atgagctgtc caaactgtca ccaattaaca gacaaagtcc ttcaagatat aaaggatatg 219781 aatgtgaaag taatcggagt acatgtcccc tatatagaag aagagaaatc tatggaggtt 219841 gtcttgacgt atgctcttga taggggacta gctattccga ttgtattaga ccaaaactat 219901 gagatcgtca caacttgtca cgtacaaggc atccccagct tttgtctatt aagtcaatac 219961 ggtcagatca ttactaaaac gatgggagat gttggttggg ataagatgtt aaaaaagatt 220021 gcaggcttgt gaaattttcc gtcttgtatg tgcgacaaac ggttgaatat tatgatgaaa 220081 cggtccttcc tataagcagg aaggtttttt aatgaaatat ttttttatta gtaggtaaat 220141 tcatcaaatg ttctgctatg ctccaaatgt acacctttcc gtaagggcaa agtcaaatgt 220201 gaaaaaaaac tgttccaaag ttaatcagaa atttattttc atattgtatc cttcggtatc 220261 aagtgaaagg agcatcatat gaaaacatta tggaaagtcc tcaaaattgt ttttgtcagc 220321 ttggctgctt tggttttgct tgtatccgtc tcggtattta tttatcacca tttccagcta 220381 aataaggagg cggcactgct gaaaggtaaa ggcacagtag tcgatgttga cggtaaaaag 220441 atgaatgtgt atcaagaggg aagcgggaag gatacgtttg tgtttatgtc cggttcgggt 220501 attgctgcgc ctgcttatga aatgaagggg ctgtacagca agttttcaaa agaaaataag 220561 attgctgttg tagatcgggc aggttatgga tacagtgaag tgtctcacga tgacagagat 220621 attgatacgg tattggaaca gacgaggaaa gcgcttatga aaagcggaaa taagcctcct 220681 tatattttaa tgcctcattc gatatccggg attgaagcga tgtattgggc acagaaatat 220741 cctaaggaaa tcaaggccat tattgcgatg gatattggat tgccccagca gtacgtcacg 220801 tataaattga gcggagttga ccgattgaaa gtgagagggt tccacctgtt aacctcgatt 220861 ggttttcatc ggtttatacc ttccgctgta tataatcctg aggtgattcg acagtcgttt 220921 ttaactgatg aagaaaaaga aatctataaa gccattaact ttaagcaatt ttttaatgca 220981 gatatggagc atgagctttt acagtcttac caaaacggca gcaaatctgt gaatctgcct 221041 gcgccaaagg aaactcccgt cttgatttta gatgcagtct ctgaccaaaa tagacattca 221101 aagtatgcta tacaaaaccg aaaagactat gaagcgtttg cggctcaatt caatactgcc 221161 gatataaagg aactgagggg aacacacagt atttatttat atcagcctga tcaaatatat 221221 aaactgtcca tggagtttat gagaaaggtt cgctaggatg aagggttatc gtattttaat 221281 cgttgaggac gatgtgatga ttggtgattt gctgcaaaag attttgcagc gcgagggata 221341 tcgtgtgata tggaaaacag atggagcgga tgtgctttcg gtgattcaga aggtggattt 221401 ggtcattatg gatgtgatgc tgccgggtga agacgggtat caaatgtctg caaaaatcaa 221461 aaagctgggg ctgggcattc cggttatttt tctctcagcc cgcaatgaca tggacagcaa 221521 gcttcaaggt ttgcagatcg gcgaggatta tatggtaaag ccctttgatc cgagagagct 221581 gctattaaga atgcggaata tgcttgagca tcattatggg acctttacgc aaatcaaaca 221641 tttgtatatt gatgcggtaa cgaaaaaagt gttcaatgaa agcctgcatg atgaggtatt 221701 atttactgcg attgagcgga aaattttctt ttatttatat gaaaatagag acagtatcct 221761 gacaaaggaa catttctttg aatatctatg gcagctcgaa gatagaaacc cgaatattgt 221821 caatgtgcat attaaaaaaa ttagagctaa aatcaatgat caagcgggtg agatgattga 221881 aaatatatat ggagaagggt atcggctgaa taccgttgtg aagaaatgaa gctcaagaca 221941 aaatatcagt tgttattgtt tacggccgtc attagtgttc cgatgctatt gctggcggtc 222001 agtgttttga tgtcggtgat ttatgacagc atgtttaaac cgatgaatca tggtatgccc 222061 tttcacaggt cgtttgcata cccggcaatg atcgttgtat ttttgatatc actcttattg 222121 ttagcttttt tattttcaaa gtcgattcat tctctgttgc ataaaatcaa tctattaaat 222181 caaaccattc ggcatttggc gagtgatcaa agggtgcccg ataaaattga agtgaagcgt 222241 gctgatgaaa tcggggaact gatcaagtcg gtcaatttgt taattgaacg gacgacatat 222301 cgtgaactgg agctgagaca gcaggaggaa atcaaaaagg agcttttgca aaaactgcgg 222361 catgacatta atacaccttt aacggctctc aggctgcagt tattttattt ggaagaccaa 222421 tgtcatggtc aggctgtatt cgaatcattg tatcagcaaa tcgaatatat ctcggaatta 222481 actaatgaat tcaatctata ttccgctgag acgctggaaa gctcttatat tgtaaatgaa 222541 gaagtgcgtc taaacgagct attagaaaca gcggtgaaaa agtgggatta tttatacagt 222601 atgagtggga ttgagctgca ctataagccg gcagatcaag atgtgatatg gatgagcaac 222661 acgttatgga tggaaaggct gtttgataat atttttcaaa atacgttaag gcattcaaaa 222721 gctaaaaaga tggaagtcac gattgaacat ggcgatgttt ttattcgtga tgacggtatt 222781 ggatttgatc ggaatgagag cagtgaggga cttgggttaa agattattga ggatacatgc 222841 aggctgcttg cgattactta tgagctgcat acaaatgata acggaacggg gttcttgttt 222901 tcaaaagagt gaccccgctg atgtttttct ttctcctata aaatttatat aatagggaga 222961 aagaaatggg gtgaacatca tatgtttaaa aaaatcatca aaacgattaa gtacctctca 223021 agcagttcta gtgaccgata tcgcagacac cggcattaca gcagcagccg gcgcagacat 223081 tatcgcagct acagcagcag ttcgggcaaa agaagacact acgaccgtta tggcggcagt 223141 catcgttaca aacgccggag ctacagcagc agttaatcca aaaaaagttc ttgttccgct 223201 tttgggacaa gggttttttt atgtgaccga ttgaatggcc cggtttagat cctcgcgaat 223261 ggaagcggtg tgctgatact cttcctcaat gcccaataat cttttcagca gcaaggttac 223321 ttcctttgtc agtgttaatt cctccagcca agtgccgttt ttcttctttt ttcctttata 223381 ttgagagtac agcaagaata acagcgtttc tccgagatcg aagaagtcat cctgttttcg 223441 tacctttatt tcctccattt cttcaggagt caattgtttg gcaaggccga aatcgatgag 223501 gcagagcctg ccatcattga tgatgatatt aggcgttctg atgtcgctgt ggaagataag 223561 gcgatcatgc aggtattcta taatctcaag cagctgcgaa atcagttgta acgccataag 223621 ctctgtgaac ggctgttttc gaaaaaataa taattcttct atattctctc cctcaatgaa 223681 ctgcatgaca taataagcct gtccgtctat gatgaattca tctatgaagc ccggaatttg 223741 cgggtggtga atgtttttga gcagttttat ttcctgctgg aatcggactt tctctttttc 223801 ctttttggct tttgtcggcc gaagctgttt taagacataa ggtgtttgag ctaggatatc 223861 ggtgcacaaa taaaccaaac cgtagcctcc cataccgagg cactcttcga ttttgtattg 223921 atgatttaag ataacgccgt tctttagagg gcggtcaaat agcagttttt ttagaagttt 223981 taatgccatg tctgcacttc ccttggttgt actgactata gtttaccttc tagacggaga 224041 ataaaaaaga gccggataac cggctcggta taagttaaaa ctgctttgtc acgtcgtatt 224101 cataatctat ttttgctttt acgttgctca tcgtcgatct ggctgtcgct aatgtattat 224161 atttaaaact ccataccttt gccacactga gttgatccga caaagagata tcataagacc 224221 ctgaagtcga gctgtttaca agggcacggc tccattcgtt attttcgctt gtcatgatca 224281 gatggcgtgt atttccctgg cttggtgttt gagtggcggt tgtttgaact ctggttacaa 224341 tggcatcacg cggtatccca gattggtttg ttaaatcaac cttgatcacg ctggagtcag 224401 aacctgaggg gctaaggctt gtatttcctt tattttcagc aacgccgctg aattggaacg 224461 ttccgctgcc tgatttgatt cggtcttcaa ttgaaagcgt aaagtacatg tttccagtat 224521 aggtgcctcg tgacactttc acatagaagg tatccgtcgt gttttgggcg tctgcatttg 224581 cataaataaa agaagaaaac gtattagggt taataacttc tgtcccttga gaaacaggta 224641 ttctgttctt gtcataaatt tcaattttca tccctgtata cgcgctctgg tatgtactcc 224701 tcatgtatac tttttctccc ttattagccg taaaagtgaa ataggcttca tcttgaccag 224761 cttccagtat tgttgtatcg atatttttat atttccaata accgatcggc attgcggtat 224821 caaatgaatt gtttcctgtg atagcagtga ctccgacagc tgatgccgaa tacgtaaagg 224881 tagataagac agaaagcata acagcgaatt gaataagcca ttttttcacc atgcaaacaa 224941 cctcctttta tttccatcat acataataac gatttaggtg taaataaatg ttttttgagg 225001 ttaatatata cattatattc gccgataaaa aagaataaga gagaatactc gggagggaat 225061 tcaatgcgtc tgaatcggca atttatccgc actcagctga ttgcacagaa catattgagc 225121 aagaatgcgc ctgccaaacg ggagaatgcg actgaaaatc cagcggcagt tctggaaaag 225181 gcatatagca ggcttaagtc acaatcttca actgggggaa tcaatcagtt caattattct 225241 aaaaccagcg tgtcgggaaa cagcgggacg ttcagcaaag tgtatcaatc agcgaatgat 225301 cgaacagtga cagacacagg ggaagaaaca gtgattcaat cccaaaaccc ctatgaatct 225361 gagagtgata tcagaatcaa aatactagat gaaaaataca gcaggatgaa tgcgattaat 225421 aaaacaaagt ctgatccatt aggctatatt aaggataagt accaaaattc aaagtctcct 225481 tatttcagaa gtgatctgtc agctgcagaa agacaggccg cttacgataa tgaaacagaa 225541 tggttattca aagggaaggc gcaaaactat aaccttcagg atgctgtgtt tcggaatgtc 225601 acatttcatg gggaagtgga agctgagaat gaaaaggtgt atcagcgggg acaggttaac 225661 cagcagctgc aagtactgtt gaatcgaaac catattcata ttccagaggg gacagagctg 225721 acgtttacaa tcacaccgat tgactatcag gtgcgggtaa gcgggacaga cgatcaggat 225781 ctgatcaagc aaattgagca agtgctgcaa tctggagaca acagcaaaga actattttta 225841 cacatcatga aaagtcaaag cagtgattca gcacaatttt ccgaagaggc ctataaaaag 225901 tatcaggcag ctcgtgagat gtatgaagtt acaggctacc atttgaagga tttagaagtg 225961 attgatgggc ggtacgtcac gcctgaggga cgtgacttaa tggatgtata taaggaagag 226021 cttgaaaaag atccagtgca gaaacaaacg gcttcttatg ctatatctta ctatcgttca 226081 gagctcagta aaatcgcgga agccgggtat aatgccattc cggatttcat cctatcaatt 226141 gattacagca atggatctct gagagatgtg ggacaaagca agagctatgg gaccggagat 226201 accgggtggc ttgaagcatt aaagcgtcaa acgggtgtga attattaggt aagctgttca 226261 tgtaggacag cttatttttt atgagaatct aaggggtgaa ttaatcccaa tattcaaata 226321 attttattat ttttatataa aagattttaa aagaagtgaa cgattcaaaa ctctgaacaa 226381 aggtgtttac ctgaaaaaaa caattgtatt ttccagagaa atttattatg atgaaataag 226441 taatttagga gattatataa caattttaag tttgaatttt ctgattgtta tcactgattc 226501 atgtgaaggc aagcaggtct gctgttttct catttatgag tattttgtta ggaggaggaa 226561 gaggagtggc aaataaagaa ttaaagaggg gcctgggcgc gcgccatatt cagatgatcg 226621 ccttgggcgg tacaatcggt gttggcttgt ttatgggttc tgccagcacg atttcatgga 226681 ctggcccatc tgtccttctg gcttatgcaa tatgcggaat ttttatcttt tttattatgc 226741 gtgcgatggg tgaaatgctg tatgtcgagc cgagcacagg ttcttttgcg acgttcggcc 226801 atcaatatat tcatccgatg gcaggttata taacagcatg gagcaactgg ttccagtgga 226861 ttatcgtcgg catgtcagaa attatcgctg tcggttctta tacgaagtat tggttcccgg 226921 atttgcctgc ttggatacct ggtatcgtgg caatggtgat tcttggtgcg gcgaatttaa 226981 tttctgttaa gtcgtttggg gaatttgagt tttggtttgc gatgattaaa atcgtgacga 227041 ttatcttgat gattattgcg ggaatcggaa ttattttctt cggttttggc aatggcggag 227101 atgcgatcgg tttgtcgaac ctgtggtctc acgggggctt ctttgcagga ggtttctcag 227161 gtttcttctt tgcactgtct cttgtcattg cagcctatca aggagttgag ctgatcggga 227221 ttacagcggg tgaagcgaag gacccgcaaa acacgctaag aaatgcgatt caaagtatta 227281 tctggcgtat tttgattttc tacattggcg ctatttttgt gatcgtgacg gtgtatcctt 227341 gggatgagct caactcactc ggaagtccgt ttgtgtctac gttctcgaaa attggaatta 227401 cggcagcggc cggcattatt aactttgtcg tgattactgc ggcaatgtcc ggctgtaaca 227461 gcggtatttt cagcgcgggc cgcatgctgt atacactggg tgtcaatgga caagcaccga 227521 aattctttaa gaagatttca cgcaatggtg tgccgctgta tggcacaatt gcggtgctga 227581 tcggtttggc tgtcggcgtt gtactgaact atatcgcgcc gccgaagatc tttgtctatg 227641 tatacagcgc aagcgtgctc ccagggatga ttccttggtt tatcattttg atcagccata 227701 tcggattcag aaaagcgaag ggtgctgcat tagataaaca tccattcaaa atgccgtttg 227761 ctccttttac aaactatttg acgattgctt tcttgctgat ggttctggtt ggcatgtggt 227821 ttaacgatga tactcgtatc tccctgattg taggcgtgat tttcttagcg cttgtggtca 227881 ttagttatta tgtgtttggg attggcaaac gcacgcaggc caatttgaca aaaagcgaac 227941 aagcagctga ataacgataa aaaagagaca ttcacggatg tctctttttt tatttttcgc 228001 gtatggattt tccctatttt agcaagctat agggtaaaga tagcagaagg aaaggtgttc 228061 ataaaatgga tgttacactc ggttatttgc gcgaatcact ttcgaatcat ctagaaaatg 228121 aagtctgcca gcgtatttgc aagaagatgc tggcgaagcg ttatgcaaat gaagaggaat 228181 ttgtaaaaga cttagatgat aatgaaatgt cttttttgaa ccatgtatta gaaaaagaaa 228241 ttaagtatgc ccagaatgaa caggatcaaa aacgggccaa ggaattaaac gaggtgtatg 228301 aattactgct ttgagaaagg cgggtaagaa atgggagcaa ttgaacgaag cggatataca 228361 tttcagccgg agtttagcgt tgtccgtcaa aacggagcca tccatgtgta ccatcaagga 228421 gaatttgtgg aagaaatcga atttgaattt aacggggaat atcccgatca tgatttgatt 228481 gaagagcttg tgaatcatta ttgttttgag catgagattt agagccctgc cgtgcagggc 228541 tcttttattt aggatgtaat caggccatac tttttcagga tatccacggt gatgtttttg 228601 gcttttgtgc cggaatcatc gacattggtg acaaagacat aagagccatg ctctgttttg 228661 atgaatccga caaaccatcc taatcccata tcagtcaggc gggttccggt tttcccgtag 228721 agcgtgtaat gatcgccttc ctcttgaatc atcatgcgct tgacgatttt catcaccggc 228781 ttgtcaaatg gaagctcctc tttagccagt ttctccaaaa aagtttcttg ttccagcgga 228841 gatattgtga gcgagctttg cagccaaaac tggtcgattc ccccgctgat atcctcgttg 228901 ccgtaagata gagtatgaag ccatgttttc attctttcct cgccgatatc tctcgctaat 228961 gcctgataat accagattgc ggattcgcgc atggccgagc caagcgtatg gtcgcggttc 229021 catgattcga attcacgctt gaccccgtcc catcgtttaa catcgtattc atctcttaca 229081 gctttgacct gcaaaccgat taaagcgttc acgactttaa aggtggattg cggagtttgt 229141 ctttgatttg cccgttttct gttatagaca aatgtctgat ccttttgtaa atcgtgaaga 229201 atgaaggttc catccgtatc cttgaattca tcatcgacat tcattttgct gacattcaag 229261 tgtttttcat gagcagatga tgctgcgtgg acggagaagc cgccgatccc tgcaatactc 229321 agcacaagca caacatatat ccattttttc attttgttct ccccttcgtt ttgattaact 229381 accttttctc tctttcgttt gttcttcctt taaaaaataa tcaaaaagcg cttaaatttg 229441 gttttgcaaa caaatactgt tactgggttt atagtcggaa gataacgtga aaatagaggg 229501 taaaaaggaa ggcagggtaa gcggatgaat gagcagattc cacatgacaa aagtctcgat 229561 aacagtctga cactgctgaa ggaagggtat ttatttatta aaaacagaac agagcgctac 229621 aattcagatc tgtttcaggc ccgtttgttg ggaaaaaact ttatttgcat gactggcgct 229681 gaggcggcga aggtgtttta tgatacggat cgattccagc ggcagaacgc tttgcctaag 229741 cgggtgcaga aatcgctgtt tggtgttaat gcgattcagg gaatggatgg cagcgcgcat 229801 atccatcgga agatgctttt tctgtcattg atgacaccgc cgcatcaaaa acgtttggct 229861 gagttgatga cagaggagtg gaaagcagca gtcacaagat gggagaaggc agatgaggtt 229921 gtgttatttg aagaagcaaa agaaatcctg tgccgggtag cgtgctattg ggcaggtgtt 229981 ccgttgaagg aaacggaagt caaagagaga gcggatgact tcattgacat ggtcgacgcg 230041 ttcggtgctg tgggaccgcg gcattggaaa ggaagaagag caaggccgcg tgcggaagag 230101 tggattgaag tcatgattga agatgctcgt gccggcttgc tgaaaacgac ttccggaaca 230161 gcgctgcatg aaatggcttt tcacacacaa gaagatggaa gccagctgga ttcccgcatg 230221 gcagccattg agctgattaa tgtactgcgg cctattgtcg ccatttctta ctttctggtg 230281 ttttcagctt tggcgcttca tgagcatccg aagtataagg aatggctgcg gtctggaaac 230341 agccgggaaa gagaaatgtt tgtgcaggag gtccgcagat attatccgtt cggcccgttt 230401 ttaggggcgc ttgtcaaaaa agattttgta tggaataact gtgagtttaa gaagggcaca 230461 tcggtgctgc ttgatttata tggaacgaac cacgaccctc gtctatggga tcatcccgat 230521 gaattccggc cggaacgatt tgcggagcgg gaagaaaatc tgtttgatat gattcctcaa 230581 ggcggggggc acgccgagaa aggccaccgc tgtccagggg aaggcattac aattgaagtc 230641 atgaaagcga gcctggattt cctcgtccat cagattgaat acgatgttcc ggaacaatca 230701 ctgcattaca gtctcgccag aatgccatca ttgcctgaaa gcggcttcgt aatgagcgga 230761 atcagacgaa aaagttaaat taaaaagctc tcttccttta tcgaagagag ctttttgatt 230821 acttcttttt ttcatcgtag tattggacgg gatacatgga gccttctgat accattttgt 230881 tgtcctcgat atcttgcggg tccgggtggc cggctttatc aactgggaac gtttccatgt 230941 ctggctgttt tgttattttc atcttcatgc tgtgaatgaa ttctcttgcc ttttggcgat 231001 ttgacgggtc ttttaataga taagaagtga tgccgacagt tgaaacagcg agacctgaaa 231061 gtaacagctt ttgtttcatg gtgatactcc tttctatttt aagaatagtg tttcctgtat 231121 cattcccgtt ttggaaattg ctaaacctgt tgtgttttta tcattggaat taacagtaaa 231181 ttccatttaa gaagaaacta gtgacttcat tcctgtattg gaaggtaata tacattgact 231241 tattatagat ttcagtcaaa attcgataaa tattgacaaa gtaaagtaat cagaataata 231301 atataattag caagagaatg tcatcataca tgaaaggtgt ttacgatatg aatcaattgc 231361 atcgaagaat gggaacgttt tccctcatga tggtcgggct cgggtcgatg atcggttcag 231421 gctggctgtt cggggcttgg cgtgcggctc aaatagcagg accagctgct attatttcat 231481 gggttattgg aatggtcgtc attttattta ttgctctttc ttatagtgaa ctaggttcta 231541 tgttccctga agcgggggga atggtcaaat acacgcaata ttcacacggt tcgtttatcg 231601 gttttattgc gggctgggcc aactggattg cgattgtgtc cgtcattccg gttgaagcgg 231661 tggcctccgt tcaatatatg agttcttggc cttgggaatg ggcgaaatgg acaagcggtt 231721 tggtgaagaa tggaacgctg actggggaag gactagcgtt tgcctctgta ttgcttctca 231781 tttattttct gctgaactac tggacagtca atctattttc gaaagcgaat tcattaatta 231841 cgatttttaa aattattatt ccgggtctta cgattggagc tttgctgttt gtcggattcc 231901 acggagaaaa ctttactggc ggtcaaagca ttgcgccgaa tggctgggca agtgtgctga 231961 cggcggttgc cacttccggt atcgtttttg cgtttaatgg tttccaaagc ccgattaata 232021 tggcgggtga agcaaaaaat ccggggaaat caatcccgat tgcggttgtt ggctctcttt 232081 ttgttgcgac agtgatttat gtcctgctgc agatcgcctt cattggagct gtgaatcctt 232141 ctgatattgc tcacggctgg agccatctga attttaattc tccttttgct gatctggcga 232201 ttgcgctgaa tattaactgg cttgttattg tgttatatgc agatgcattt gtatcaccgt 232261 ctggaacggg gattacgtat acggcgacaa cgtcccgaat gatttacgga atggaaaaaa 232321 acaaatacat gccgagtata ttcgggaagc ttcatccgat ttacggcgtt ccgcgacaag 232381 caatgttctt taacttgatt gtttcgttca tctttttgtt cctgttcaga ggatggggcg 232441 tattagcgga aattatttct gttgctacgt taatttctta tatcaccggc ccgatcacag 232501 tgatgacatt gagacggacg gggaaagacc tgtacaggcc tcttcgttta aaaggcttaa 232561 atgtgattgc tccgcttgga tttatctttg cgtcactggt gctgtattgg gcgcgctggc 232621 cgttaacagg acaggttctg tttattatcc tgatcggtct tccgatttat ttctattatc 232681 aggcgaaggc gaaatggaaa gggtttggcc ggaactttaa agccggcgtc tggatggtgt 232741 tttatctgct ggccatgatg gttatttctt atttgggcag tgataaattc ggcggcctga 232801 atgtcattca ttatggctgg gatatggttc tgattgcgat ggtatccctt gtattctatg 232861 tgtgggcgct gaagagcggc taccagacag aatacttaaa ggatgcgaaa gagataaatt 232921 ctcagctgct taatggacag tcagaagctg ctgccggaaa agaataaaat atagaagaaa 232981 accttgcgat agttgtcgca aggttttttg cttttaataa ccctttttta ctttgtggaa 233041 aagatcagga tagttggtga acactcctgt tacgccccaa tcaagcaggc gatgcatatc 233101 agcttcatta ttgactgtgt aaggatgaag caggaggccg tggctgcgga tcatacggac 233161 gttttcttga tttaaagctt tataatccgg gcccgcaccg acagcgtatg ttttgatttc 233221 ttccagggca gcatctgtca ttgacgccat ttgtttggct tccagcaatt gaacggtcgg 233281 caggtttggc tgtaattgat ggacttttac caggctttct ttgctgaacg attgaatgat 233341 cacctggcct ggcttagaat gctttcccag taatttatgt ttctgcaaag aagcgatcag 233401 tttttcttcc atacctgggt aggtgtcagg cgattttgtt tcaatgtagt agttcgcgtg 233461 ctttccgaaa cggtctaata cctcttctaa tgtaggaact ttaaggccga cgtactgcgg 233521 ctttgctttt tccggatagg cttcattaaa ccaagaaccg gcgtcaagct tcttaatgtc 233581 tgcgagcgta tggtctttca cccaacccat tccgtttgtg gtgcggtcca gtttttcgtc 233641 atgcatgaca atcaattttc cgtcttttgt catttgcaga tccaattcaa taaaatcagc 233701 tttcattttc tgagcggttt cgtaagacag aatcgtgtgc tcaggcacat atccagaagc 233761 ccctctgtgc gcgacggtca ggatacggtc aggtgacagc aggtttcctt ttgacgctgc 233821 cgacactggc gttaccataa atgagagtaa gcccagcgac agaacaaaca aggccagtat 233881 tctatttttt ctcatgattt ctcctcctta tagataagca ctacctgtct ttcataataa 233941 aaaacggatg taaacggcgt gttggaaaac tattaatctt ttatgtgtct ttcttaaaca 234001 tgctctgccc gttttcctgt attccacgtc aaagccaaga agacgatggc aagaatgcag 234061 gatgagatca gcatgataaa gccgccgttc cagttaaaac ggtccacgac aaagcccata 234121 atggcgtttg cgaaggcgga tccgccgatg tatccgaaaa atccggtcaa accggctgca 234181 gttccggctg cttttttcgg tgctaggtca attgcttgaa ggccgatcag cataacaggt 234241 ccgtagatta agaagccaat gctgatcagg gcgatattgt ccacgagcgg attgccggcc 234301 ggattcagcc agtacaccaa tacggcaatg aaaacacccg ccataaacaa aacgcctgcc 234361 ggtgcccggc ggcttttgaa gaatcggtca ctgatccagc cgcacaagat cgttcccggt 234421 atgcctgcgt attcgtaaag aaaatacgac cagcgtgagt cttcaggaga aaagcctttg 234481 gcttctgtta agtaagtagg cgcccagtca accacgccgt atcgcacgaa ataaacaaat 234541 acattggcaa aagcgatgta ccaaagaaat ttgttgttca gcacatattg aaaaagaatt 234601 tcttttgttg ttaattcttt ttcctgattt ttaaaagcgt gttttggata gtcattccga 234661 tactcttcaa ttggcgggag tccgcaggat tgaggcgtat cacgaaccaa taaaacaatt 234721 aaaaatgaaa tgataatggc gatgatggca gggaagaaaa acacgctttt ccaagtgacg 234781 aacatcgcga tcccaagagt gacaagcgga gcaagaatac cgccgcctat gttatgggcg 234841 acattccaga tcgacatttt tgtgccgcgt tcacttatgg agaaccaatg ggccatcgtc 234901 ctgccgcatg gcggccagcc cattccttga aaccatccgt tgataaacat aaaaataaac 234961 atgatggtga cgctcgaagt cacccaaggc attgaaacga atagaatatt aacgattgct 235021 gataaaaata ggcctgtcgc cagaaaatat ctcggattac agcggtcaga caccattccc 235081 atgatgaatt tgctgaagcc gtacgcaatg gacacagcgg ccagcaccaa acccagttct 235141 gttttcgaaa atccctgttc ctgcagataa ggaatggcaa aggcaaagtt tttccgcagc 235201 aggtagtagc ctgcgtagcc aatgaaaata ccaatgaata cttgcagtct gagccgtttg 235261 tatgccgcat ccatctttga atcatccagt ctctcaatat gaggagccgg tttaaatata 235321 ttaagcatta ataattatcc ccctttgctg tttgtgctgg atgtgtggcg tgcctccttt 235381 cccgaaaaac aaaaagagcc agaaaacacc ccttgtcaaa aggggttgga ttcctggctc 235441 tcctcatctc catccaagct attaacttat catgatagcg ctttcttaaa ttatcatagt 235501 ccggagcgaa tgtaaacggg taattttcaa attgggcctt agggaagtga atattatcct 235561 tttactaaat gcaattatat ttttttacta gtaacataaa aatctggagg gaggctgttt 235621 aaagatggat gaattagata tcgcattctt tattttaccg ttaggaatta tgctgctatc 235681 gattgtcggg acctgtattt gtaaaaaccc gtatctgatg ccaatgctta gtttggtgat 235741 ttctcttgtg ctcaccttta ccatttttaa tcaatcattt ttgggatggg ctgttgtcta 235801 tagcttggtt tctctggctt tatcctatat cacattgatt gtggtaagga aaaggaagga 235861 atcaggaaat taaaaagacc tcactttcta acatatcgtt gactaaagca actatatgtg 235921 attataattg ctttagtcaa cgatattaga aagtgggaat tgatttgaaa acaagagaat 235981 catctgtcgg gttaaaattc agaaagttca atcgatttta tacaaacgtc cttggtttcc 236041 ttaatgagca catttacgac agcccgtttt ccttaacaga aacacggatt ttatttgaga 236101 tttataatac gcctaattgt acggcaaaag ctcttcagga taagctgggg cttgaccggg 236161 gatatgtcag caggattgtg aagcagtttg aaaaagaaga tttgatttat aaacagagga 236221 gcaaagatga cgcccgccac cattacattt ttgtcacaga aacaggaaaa acgatttata 236281 aaaagctgga ggagaaagcc aacgaacaag tagaactgat gctgaaggta atcaaccaaa 236341 aggagcagca caagcttgcc gaggcgatgg cagagattga agcgatcctt tcacagtcgc 236401 tttctgccag agcatcagag atatcgatta gagattattt tctttcggag gatcttcaac 236461 tccttattga gaaacaaaga caattttacg cggaggctca cggttgggat gacacgtttt 236521 tagcttatct tcaggagaca tttgacgctg acatcgaaaa aatatggatt gcggaaagcg 236581 gcgggaaatt tgccggctct gtcgggttgg tcaagcacga tgaaaagaca gtccagctca 236641 gatggtttct ggttgatgcg gattttcggg gcagggggct tggcacgcaa ttgctggagc 236701 atctggttgc atactgccaa gacatgaagt ttgaccgcat tttcctttgg acggtgagca 236761 cgatggctga ggctcgtccg ctctataaaa aatttggatt caggataagt gaagtaaaac 236821 aagaagcgcc attatgggga cagcagctga cagaagaacg gtgggatttg gagctgtcat 236881 gaaaagactg cattatgcgt ggatcatcgt ctccgtcacc tttttgatct tattggcggt 236941 tcagggggtg cggctgtcgt ttggtgcgtt tgtggagccg tgggaacggc agttttcaat 237001 cgatagaagc accatctcgc tgatttcgac ggtgagtttt attgtttatg gcatatcaca 237061 gcctgtgatc ggtcggcttg tggacaaatg gggtgcccgg gctgttttgg catggagtgc 237121 gttactgaca ggagtcagca ttttcttaac ataccttgtg acttcgcctt ggcagctgtt 237181 tttgctttac gggctgggtg tctcgcttgg agtgggcgga gcatcgaatg tggcggcaag 237241 tgtattggtc gtcaattggt tcagcaaaaa gcggggacta gcctttggga tcatggaagc 237301 aggctttggc gcggggcaaa tgcttctcgt tcccggctca ctcatgttga tccattggtt 237361 tagctggaag ctgacggttg tggtgttggg actgctgtta atcgtgattg tctttccggc 237421 tgcgctgctg atgctgcgga acaatccttc agaaaagaat acagagccga taggcggact 237481 ggctgcatca gaaaaagaaa cagcacccaa aacaacagct ctttcagtgg ccgggatgtt 237541 tcgtatgagg caattctggt tcttgatttt tccgtttttg atctgtggat ttacgaccgt 237601 ggggctgatg gatacccatt tgattccgtt ttctcatgat catggctttt caacgacagt 237661 cacgagtgct gctgtcagtc tgctagcagg ctttaatatt gctgggatct tgctgtccgg 237721 aattgtagcg gaccggtgga gcagccggaa aatcctgtgc attttatatg cggtgcgggc 237781 gctgtcgatc gtgattctta tttacagcca cgagccctac ttgcttttag cctttgcgat 237841 tctgtttgga ttagtggact ttgcaacggt agcaccgact caaatgctcg ccacccagta 237901 ctttcaaaac tactcgatcg gcctcatgat tggctggctg tcactcgccc atcagatcgg 237961 atcggcacta ggtgcgtatg tgcccggcgt catctacacg gtaacgggtg agtatacact 238021 ggctttttat ttgtcgattg gaatgctcgt gcttgcgagc gtaatgaatg tgatgctgag 238081 ggagccagct gcggttacgc gtgacagtgc ggctgtggta gacaagtgat gaggacaaag 238141 ggaaagcatc tctgatttcg agattattca gagatgcttt ttttgtattt ttgttctaat 238201 acgaagtcga tcataccgac tatgcgggcg ttttcggatt tttgtttgaa gcgttcagaa 238261 atttgaactt ttcttgaaaa tggggaaaca ataaaaaccc aaaaaaggcc gatcaaggca 238321 aaaaacattt gtacagctaa ttctattaat tcattaaaac gagtgctgaa aaaatagaag 238381 tataacgtta ttaatgtcac agtacatacg attttggcaa gtgtgtttga atgtaagcaa 238441 tggttcacta aagaatacct ttaattgatt cagcatgatt gaatcatatt tgtttaggaa 238501 aataagaagt tctttatcat cttttttatg ttctaaaata aagttgctgt ttctgtttct 238561 ttatatgtat ggtggtctac attcaatata tacatctctt aaagtataaa aattgagtat 238621 ttcttagtaa ggatgaaaca aaattacatg atttttttgt tatatctttc agttagaata 238681 aaatctataa ctcctctcat tcgcaaatat tcggctctct gtgcaaagtg cagaacagta 238741 tgtaattgtc cttttctaga tatatttaaa agctttatca aatcaataag gattttcaag 238801 aaaataatta ataatagaaa gataaaaatg tgtggtatgt caatgtaatt gatttgtcct 238861 gaaaataaag aagttgcata gacaacaata atacttccgc aaaacatcaa actcatataa 238921 tgtggaaggg aaaatggacg agttgaaaaa tatgctttta attggcttag catagcatta 238981 tctcttgtat ctaagtagcc caaaagctct ttatcatttt tactaattgt aagaacatga 239041 ttcaatacag cactaaaatt cattgaatct tcattatcag aggcagtatg tttattagcc 239101 tgtatgtttt gttgatccat tttatatttt ttataaagta ttgtattaat taacttgttt 239161 ttctcataga attcagatcg ttgattaagg gatgcttttc ctttgttttt atttcctttt 239221 tttatgattt tagtataagt cataaaaata caaatgactg taaaaataga aaacactgca 239281 ggtgaaatat ctgaaagaat agtattggtg aagacttctt ttgcttggat gaaaaggaaa 239341 gaagctaaag tcatagatat aaacatgcat aaaactgcta ctttcacaag aaactgaagc 239401 ggaagagaag gttccgaata atagtgcttc aactggttga gtgtcagaga atcttggcga 239461 aaaagataat ctattatctc ctgctgattt tgcatctgat tgatatcatg agcgatgttt 239521 tttgtttttt caaaaactat ttgatcattt ttcatttttg ataaacctcc aaaagacgat 239581 agataaacta aaaaaactgc atgagcatat tttaacttat gttcatgcag ttttgtatta 239641 aagttagcta gtataataag caaaaatggc cagtaacata gcagataatg cggtagcgac 239701 tttgactcct ttattgttcg ttaaatcact gcccatattc ccaattagta aaagtgcagc 239761 aacacctaca acagggaata aatattgatc ataagacggc caatctaacg ctaattcact 239821 ctcgggagac gtaactggta ctcccttgta cgtctttatt ttaaacgtaa tcgtagtcgt 239881 tagtccagtt gtgacattgt caccgactgg aatatcaggt gtatagattt taatttgaat 239941 gtttaaagat tcagctgttg gatttacata aacctccaaa taaccgttgc gtactgataa 240001 gctcagacta tttaaaaggt tttgataaga gtcgatttgt gacgcagtga gagacgtttg 240061 agtgtcgccc aataaacccg tgatataggc acctggttta ccatttgtaa tggtaattgt 240121 gtttggtgaa ccttcacttg gtatggttgc cagaagtgaa gttgatagaa taatatccaa 240181 ctcaggtgat gtgaaaatgg tttctgtcgt atcaaattca aacatcgcgt ttgccagact 240241 tgttagattt tctaaagctg gaatggtaga taaaatgtct gtcagtgtac gcagtcttgc 240301 atcatatacc ggatcagacg gcggatttac attgcttgca cctgagtctc ttcctgaata 240361 cccgtcttta tcaatcccga tgcttccaga gccgcttccg atggttcctt cataaaattg 240421 atcaaaggcc cagttgtttg gcatcggata gccgagattg ccgctaaatc ctgttgacat 240481 atttgccaca aaactatact ttgtcagtcc tgcttcagat gtacggatac aaatgtttct 240541 tggtccgtaa acccctattt catacttagg tgcggttgaa aatgtctgca tttttgtaaa 240601 tgctgactta atctcttgga aataaggaat gattttatcg gtcacttcat aatcgtatgc 240661 atcaaaatcg acagcgaaat aaatggtcgt gcctgacgga aaacctaatc ttctagcagc 240721 agaagcggca ctatatgcat ctcttgtgcc ttggtctttg acaaaataag aagattcata 240781 gccgccgtct tgataaattg ggaaaacctt caatccggca tcaagaataa ctgcaagctc 240841 tttagatgtc agggctttag atgtgaggcc gctgcttgtc cgcacatttc cggtcaaata 240901 tctgccaacc gttttataac cgttattccg cagtgtttga gctttttctg cggttataat 240961 tgtagcagtg tcacaagcag aagcggtgcg agttgtgtct cctgagcttg ataataaagc 241021 tttaatggtt ggcatatctg cataacctgt ttgcggcagg cacatgaact cttgaaatgc 241081 tttaacagct gaaacaacac ccacaccata tttgccgtca aactcaccag gatcgaacga 241141 ttttccgtta caatagaggg cgtactgaac aattaagaca aatcctgttc ttgaatcgcc 241201 gggagttaaa gtagggcaca aacttgtggt gccgtttccg aaaaatccat tggcaacact 241261 tgtgctcatg ccttcttctt tttgcagggc ataaataaga gctttatttg tatcgcggcc 241321 atacagtccg tcacaaggca ttaacccgat atagtcattg tagtctcgat ttaagttttg 241381 ttgaatctgg cgaattcttg aatcaccccc agacaccagc ttaaaagcgc tcatgtctaa 241441 taaggctttc ataattaacg tggtgacaat cccatcctgt gttgtcagtc cggcagcttt 241501 ttgaaattct tttaccgcat tttctgtttt ttcgtaaaag acgcctgtaa aaccgccggg 241561 attaaagcct ttacaccata aagccccttg taaaataaaa ttcatgttgc ttggttttga 241621 atctggagct tggcgtttaa gaggcttaaa taagcgctgt gttgtcggcc cgaagttatc 241681 ggctggctct gagataccca attcaatttg aagcgcccga gtcagaccgt agatcgtatc 241741 ccacccagtt ttcccgcttt cttcaactgg gttataccca tgtttgccgc tgtacgtatc 241801 gttcagccat tgctgtgtga ttaagaccat ttcatcaacc atttcgattc ctcctttgtt 241861 agattgcgtt catttatagg tggcaaacgt aggacaaaat aaaaaaatgg atgccgttaa 241921 gcatccattt tacatccgtt ctccaacagc ttcgctttcg gtttcagctc tgaaatgtag 241981 aggcctaaaa gtgtaagcgc gcctcctaga agagcgatcc atgtcatgtt ttcgtgcaga 242041 atcaggacag aagcggcgat cgtgataacc gggaccatgt aaatatacgc actggatttg 242101 acggctccga gcactccaac tgaataattc caagtggcga agcacagggc agaagcgcca 242161 atccctaaga aaagcatgtt gagtatattt gaagcagatg aaaatcggct taggtcaaaa 242221 tggaagtcga acaaaaataa agcgggaacc ataaacaata aaccatacaa aaatactctc 242281 tgtgtcagct cgatgatgtg gtattcgtag gcgcttaatt ttttcatgaa tatcgagtat 242341 ccgccaaaca cgagagcagc cccggctgcc atgatgtctc cgagcggatt tagacgcagt 242401 accacattgc cgttaaacgt aatcaataaa agcccgatca gtgccgagat aaatccaatc 242461 aaaaaagtca gacgcaattt ttcgccttcg agcagaaaat gggccaaaac cgcagtgatc 242521 atcggtataa tggacacgat catgccgaca ttggaggcgt atgtataggt gagagctata 242581 ttttctaata gaaagtataa ggttacgcca aataaaccag ctccggcaaa caacagctcc 242641 tgccgccaat ttctgaacgg aatcatgttg ggacggacga ggataagagc gataaagccc 242701 atcaaaaacc gataaaataa tatttccatt ggagagaagt cagccagcag aacttttgtc 242761 gaaataaagg tcgtccccca aatcagaatg gtcacaatgg ctgcgatatg ccccgaagtt 242821 tctctttgta tgttcatctg tgaagctcct tttcaaaaat cttcatgtat tgcttcggcg 242881 tcagccccac ctgccgttta aaaaacttcg tcatatgact ctgatcgctg aatcctgtct 242941 gaaatgccgc atcaatcggc cttacccctt gttcaaggag ttttttggct tgattaatcc 243001 ggattgtttc catgtagcta ttaggggtaa tgcctttttg ttttgtaaat gaacgcaata 243061 aatgatactt gctccagcct gttaattcac tcaaatcatt gagtgtaaca ttttcggcat 243121 aatgctcttc taaaaattca caaaccattt tgacttcgtc tgatggttct ggaacgctgc 243181 taaggaacgt gacatctgaa taatggcgga tcagctcctc taatagatga agaaacagct 243241 cctccttacg caaagcttgt ttttcctcgg atatcaaaat atgcaattcc tgcaggctgg 243301 ctgtcagctc atggcggaat aacacatgct gggagaaata agggagatgc ccggagccag 243361 taatctcttt caccgccttc tccatgatat ccggcatgac attgatacac cgataatcaa 243421 gcgtccggcc gtcaatctgt tcacagctat gcgtgtcacg ggggttaaag aggagaagat 243481 cacctggatt gatgatatat tcttgatcct gacaggccag ataccgttgc cctttttcaa 243541 taaatccaat cacataataa tcgtgaaagt ggttcgggaa cttctgcata attcccttga 243601 agcggtaggc ttctatatga aggtgtgggt caagctgcag tgtgcgggtt tcgttttgca 243661 tgggatgcct cctgtcggtg tggtggtctt ggattaagtg tagcatgatt ttgggggatt 243721 tcttgtatga tgttgctgtt taggaataga gaaagcagac cgttatttgt ctgctttcgt 243781 ttaagaattt aaaagatttt aaccctcaat aataatttta tcttttttaa taaaaattta 243841 tttttcaaat atttcagtta taatggtttg gaacagatag gaggggcaaa gatgtatcaa 243901 tcaaagaagg ttttattgtt aggttcaggt gaattaggta aagaggtagt gattgaagcc 243961 cagcgtcttg gggtacagac ggtggcagtt gacagttacg agcatgctcc ggcgatgcag 244021 gtcgcgcata acagttatgt cgttgatatg ctggacccag agcagatcag aaccatcatt 244081 gagaaagaaa atccggattt gattgtgcct gaggttgagg cgattgcgac ggatgaattg 244141 ctgaagcttg aagaggaagg atttcacgtt atcccgaatg cccgtgcggc caagctgacg 244201 atggatcggg aaggcatcag acgacttgcg gcggaaacgc ttggacttgc gacagctggc 244261 tatgaatttg cgaatacata tgatgaattt atacaagcgg cagctcagat cggttttcct 244321 tgtgtcgtta aaccattgat gagttcttct ggaaaaggcc aaagtgtgtg ccgctctgaa 244381 gcggatttag agagctgctg ggagacggcg atggaaggcg gacgggtgaa aaacggccgc 244441 gtgatcgttg aggagtttat ccctttcgaa tcagaaatca cactcttaac cgtacgtgcg 244501 gttaacggta cggcattttg tgagccgatc ggtcatgtgc aaaaggacgg ggattatatc 244561 gaatcgtggc agccgcatga tatgacagag cagcaaatag aagaagcgaa gcatattgcg 244621 aaaacgatca cggatgagct tggcggatac ggcctgtttg gtgttgagct gttccttgcg 244681 aaagataggg tatatttcag tgaggtatct cctcgtccgc atgatacggg tcttgtcacg 244741 ctggtgacgc aaaatttgtc agaatttgcg ctgcatgtcc gggcgattct cggctttccg 244801 attacagaaa tcacacagct ttctcctggc gccagcaggc ccctcaaagc gccggaagaa 244861 ttagcggatt acactgttga aggattggaa aacgcactgg cagtcccaaa gactcaagtg 244921 cgcgtctttg gaaagccgat aacaaaagcc ggacgtcgta tggcagttgc gctttctgct 244981 gctgattcag ttgaaacggc aagagagaat gcaaagaaag cgttggacca gctaatttta 245041 aaatagagtt tgaacaggtc ttgtcatggg acaaggcctg tttttttctt tctccgtaaa 245101 agttttatca taagaatcag aaacctgatt ataatgtaaa agtcttccat cgatacgggt 245161 ggttgacact aaaggaggga gatgacaaaa tgaaattagt tccaagattc agaaaacaat 245221 ggttcgctta cttaacggtt ttgtgtttgg ctttggcagc agcggtttct tttggcgtac 245281 cggcaaaagc ggcagagaac ccgcaaactt ctgtatcgaa taccggtaaa gaagctgatg 245341 ctacgaaaaa ccaaacgtca aaagcagatc aggtttccgc cccttatgag ggaaccggaa 245401 aaacaagtaa atcgttatac ggcggccaaa cggaactgga aaaaaacatt caaaccttac 245461 agccttcgag cattatcgga actgatgaac gcaccagaat ctccagcacg acatcttttc 245521 catatagagc aaccgttcaa ctgtcaatca agtatcccaa cacttcaagc acttatggat 245581 gtaccggatt tttagtcaat ccaaatacag tcgtcacggc tggacattgt gtgtacagcc 245641 aggatcatgg atgggcttcg acgataaccg ccgcgccggg ccgcaatggt tcgtcatatc 245701 cgtacggtac ttattcaggc acgatgtttt actccgtcaa aggatggacg gaaagcaaag 245761 acaccaacta tgattacgga gctattaaat taaacggttc tcctggaaac acggttggct 245821 ggtacggcta ccggactaca aacagcagca gtcccgtggg cctttcctcg tcagtgacag 245881 gattcccatg tgacaaaacc tttggcacga tgtggtctga tacaaagccg attcgctccg 245941 ctgaaacgta taagctgacc tatacaaccg atacgtacgg ctgccaaagc ggctcgcctg 246001 tttatcgaaa ctacagtgat acagggcaga cagctattgc cattcacacg aacggaggat 246061 cgtcatataa cttgggaaca agggtgacga acgatgtatt caacaatatt caatattggg 246121 caaatcaata aatacagcaa actagccata ttcatgtcta ttttgttttt atgcgggtgc 246181 agttcgcaga cgcattcttc tcaaaaagaa acgactattc ctgtcactct tcatgtggag 246241 gatgctaagg ggctgccggt cgaaggggtt caagtgacga ttgtcaaagc gccctcttca 246301 gatgaggagc cgagtacaga gattggcgag atactcggta aaacagacaa aaacggagat 246361 atcaaatggg ataccggcag aaaaggcgat tactcagtcg cgttgacgaa gggtgaaaca 246421 tcagtaaccc atcacatctc gttaacagag gataaaaaag atcatgccat tccattagtc 246481 ttcaaagaat agcagtttcc ttgattttaa gggaactgcc ttttttattt attgcaggaa 246541 accaaactat atactggaaa tttattatgt gagataataa gaaataggta ttttttctta 246601 cgagacaaaa ggggcgttat cctttatatc aatcaaaccc ggaggaaaaa gaagaagatg 246661 atacaagatt caatgcagtt tgccgcggtt gaaagtggtc tgcgctttta ccaggcatat 246721 gatcaaagcc tttctttgtg gccgattgag tcggaagcat tctatgtttc tactcgtttt 246781 ggaaaaacac atatcattgc aagtgggcca aaggacgcac cttcgctcat tttgcttcac 246841 ggaggccttt tcagctctgc gatgtggtat ccgaatatcg cagcgtggag cagtcaattt 246901 cgtacatatg cggtcgatat aataggagac aaaaataaaa gtataccatc agcagccatg 246961 gaaacgagag ctgattttgc agaatggatg aaagatgtct ttgattctct tggacttgag 247021 acggcacatc tggccggcct ttcgcttggc gggtcccata tcgtgaattt cttactccgc 247081 gcgcctgaaa gagtagagcg ggcggttgtt atcagtcccg ctgaagcgtt tatttcattt 247141 catccggatg tctataaata cgctgcagag cttacagggg caagaggagc tgaatcatat 247201 atcaagtgga tcacaggcga cagttatgat ctgcatcctt tactgcaaag acaaattgtg 247261 gcgggcgtgg aatggcagga tgagcaaagg agcctgaagc cgacagaaaa cggctttccg 247321 tacgtgttca cagaccagga attgaaatca atacaagtcc cggtacttct gatgttcggt 247381 gagcacgagg ctatgtacca tcagcaaatg gcctttgagc gggcttcggt attggtgccg 247441 ggaattcagg ctgaaatcgt aaagaacgcc ggacatctgt tatctctgga gcagccagag 247501 tacgtcaatc aacgcgtctt gtccttttta tgcgggggga taaaatagta aggaacatga 247561 aaagattggc attcattttt caaaaggtaa caaatgttgt ataataatag aatttgaatg 247621 ctgctttttt tgggagcatt ctatgttatc atgcttattg gagaaaaatt tttcctgtaa 247681 cgctattcga tcactatcgt caaataatat agatggtttt acaattggag gtttggttac 247741 actgtgaatt acatcccctg tatgattacg ataggaaact tcatttgcgg attgctggcg 247801 attcattcct tgctatatca caacattcat tcagcagtgc tttttatttt tacaggcatg 247861 ttccttgatt tctttgacgg gatggctgct cgtaagctga atgccgtttc tgatatgggg 247921 agagaactgg attcgtttgc cgatctggtt acgtttgggg tggctccttc tatgcttgct 247981 tacagtgtcg cgttgtatac cctgccattt atcgggatct tatgcgcatt gacgtacagc 248041 atttgcggaa tgcttcgcct ctctaaattt aacattgaac aaagcaagct cccgacgttt 248101 atcggtatgc cgattccgtt tgcgggcatg tgtctcgtta ttctaagctt cacctataac 248161 ccgatccttc tggcaatcgg cacttgcgga ctctcatatt tgatggtgag taaaataaaa 248221 ttccctcatt ttaaaaaaca tgcggcagaa aacctggagt ctgggagatg gaattagttc 248281 agcagctcat agcggattac ggttatctcg ctattttttt gatgctggta ttaggaattg 248341 taggattgcc gattccagat gaagtgatga tgaccgttgt tggctatttc acgcataccg 248401 atgtattgaa ttatgagctt tcgatattga ttagttttgt cggggctttg ttaggtatgc 248461 tgatcagcta catgattggc agaaaagccg gacgcccgtt tatcgacaag tacggcaagt 248521 gggtcggctt aaaagaaaaa agaatgatga aagtggaaaa atggatgaag aaatacggtc 248581 catattctct tattttaggt tattttattc ccggcgtcag acatgtgacg tgctactttt 248641 cggggatcgg caaaatggat ctgaaaacgt atgttgcgtt tgctgcaatc ggcgcctttt 248701 tatggtgctt tgtttttatt acaatcggaa gggttatagg gattattcat gtttaatacg 248761 gctgtaaaga ttctgtatcg atcattgata gagctgacga atcatcgtct gtcatcctat 248821 ctgattaaag gattttgcga gtcgaaaatc agcaaaccgg tcattccgct tttctcaaaa 248881 cattttcggc tgaattggga tgatgtggac ggtacggctg ctgattacgg atcgctgtcc 248941 gaattgttca ttcgacaaat aaatctggag cggcgccctg tgtcaaaaga ggcgcatgcg 249001 gtggtcagcc ctgttgacgg tgtggttcag acggtaggaa tcatcaaccc gaatcaaacc 249061 tttacggtga agggaaaaga ttactcattc gctgagctga ccggctgtaa aagcgcagac 249121 catcaataca acggcggata tttcgtcgtg ctgtatttaa gcccgaggca ttatcaccgt 249181 ttccattctc cgatcagctg caggtatcaa aagctggccg agctcggaaa tcgctcatac 249241 ccggtaaatc aactaggctt aaaatacggg aaagatgtgc tgtcgaaaaa ttatcggttt 249301 gtgtacgagc tgaatagcgg cagccgaaat gtcctgatga ttcctgtcgg cgcgatgaat 249361 attaattcta tcgtgcagac gaatacccgt actgaattgg agatcggcga ggagctggga 249421 tacttttcat ttggctcaac cgtcattttg gtttttgaaa aagacgcgtt ccagccgtcc 249481 gcccatttag cagaaggcca agaagtccaa gtcggagaac tgataggtta cgaagaataa 249541 aaagaggagc ttgcataaac gcagcgcctc tttttttgaa gaaaggtgag attcatggag 249601 aaacaaatca tcagctggat tacagattat cagaacaccg gagatgaagc cgtcctgcgg 249661 caagtgcgag aagtgtgctg gccgatcgtt gaagcggttt tgcaagagaa agtaatggat 249721 gatgaacaag cgaacaattt gcgcgaaaaa ggaatcgagc ggtttccatt catcatcagc 249781 aaataccaag cggatgtgca gcttccggtt gagacatttt tacaaaatac gtatcggttt 249841 tactttcatc aggtgatgag agaatccagc taaagcttct ttcaacagag aagctttttt 249901 ttgttggcag gaaaaggaaa ctttttctat atctatctcg taatgactag agaacctagc 249961 agaaaaggag agatagaatt gaaacgaatg atagtgagaa tgaccctgcc gctgctgatc 250021 gtttgtctgg cgttttcttc tttttcagcc tcagcccgtg ctgcttctga agaaaaatat 250081 tgggatcact ggattgaacg acatgcacag cctctggatg cttccaatgc ttcaaacaaa 250141 gaccttcgat ttctaaaaaa ggtgctgaag ggaaaacgaa tcgttcagtt aggagaaacc 250201 acacacggtg ctggcgaaat caatgccaca aaggtcagaa tgatcaaata cctccacgaa 250261 gagctgggat acgatgtatt ggcctttgaa tccggctttc ctgatacaaa tgcatcctac 250321 cttaatatgg accaattaac ccctaaaagc acgatgaaaa actccattta cgctgtatgg 250381 cacacagaag atgtcgtcga attgtttgat tacatgaaag agcaaaaaga gaaaggcgat 250441 ccgctgatcc ttaccggttt tgatattcaa agcatgaaga attcattcaa tgtagctgcg 250501 actcaatggg taaaagcggt ggaccctgag aaagcagagt tgctctccca atcagaaaat 250561 gatttttcaa cattagtgac agacagcaat acgtttgatg aattttcgca aaagaaggaa 250621 aagcttgtga aaaactatca gaagctgatc aagttcacta aaacacatgc ttcagagcta 250681 aaagaaaacc ttccaaaaga gccgaaagct tatgagatgt ttatgcattc tcttcagctg 250741 agaattgacg taatggaaac atatatgctg gaagaaatga aagaaaaact agaggagtat 250801 ccggagaata ttgaggattt ttcattcttt atgagagacc gcatgatggc tgaacaattt 250861 cagtgggtag ccgacaccct ttatccgaaa aagaaaatca ttgtctgggg ccacaattac 250921 catctacgca aacagaatac gaagatgata aaggactggg tacagctaaa cggccctaac 250981 atgggtgatt atttgccgga gcggctgaaa aaacaaacat atacgattgg catttatgct 251041 tactcaggtg cgagtcttga tagctccgat aataagactg ttaagccggt tacaagcccg 251101 ccgccgtctg ggagccttga agctttgctg aaagcggcgg accgaccggc tgtttttgtt 251161 gattttctcc atacaaaaaa caagaaaggc acttcgtgga tgtatacccc gcggactgcg 251221 ctctattggg ggtacatgga agagcagatg atcctgaagg aacaatatga cggtgtcatt 251281 tggctggagc atatcacgcc ctctgtcatt atcaagtgag cggtgtcccc tgtggtaaac 251341 aggggatttt tacatatcgc aaaaataatc aaaacatata atccgtgatc cattattcta 251401 aaacagaaag gagattggag cgtgcaatgt attatgaaaa agctgtccag aaaacaatca 251461 attggattga atcacattta catgagcaaa tatcaaacga ggatattgtt aacgtttcaa 251521 gcttttcaaa attccatttt catcggattt ttcaaaaaga agtcggcatg tcggttgctt 251581 cttatattcg gttaagacgt cttgcgaatg cggcggcagc tttgctttat acagatcatc 251641 gtattatcga tattgctttg tattatcagt ttgaatctca agaagcattt acgaggacgt 251701 tcaaaaagat gtatcacatg ccgccaggag cataccgaac atttatgaaa cgctttactt 251761 caaaaaagga ggaatcttac atggagaaaa aaatgaaagg ctgggtattg agcgggagcc 251821 atccgttcca attcgaaatg gggattgacc gggaaaatgt acatcaggga aaagcttcag 251881 ggtatttaaa gtcaacgatg gttcaggata tcggtgaatt tgcgacgatg atgcagcaat 251941 tcaaagcaga tcgctatcta ggaaaaaggc ttcgtctatc aagttttatc aaaacaaagg 252001 gggtgcagca ttttgcctca ctttggatgc gggttgacag tgctgctgat gatgttctcc 252061 aatttgataa tatgagcaac agacctatta ccggaacaac caattggaat cattatgcta 252121 tcgttttaga tgtcccagaa aatagcgctg tgatatcttt tggcgttcaa ttatctgggc 252181 cgggtcaggt gtggatggat catgttgttt ttgaagaggt agatgagagc gttccttcaa 252241 caaaccttga aatgccggga gaacttttag atgaaccggt aaatttatct tttgaagagg 252301 aactacaaaa atagttttca gacaactact tttattagtg agttaatgga aaatactatt 252361 tgttattaat aaacccttgt gctgcttagg tttgtaagag cttggatatt tttatcagtc 252421 tgggcggatc tgttcatctt tgcggcattt tcctgtatga tatagtaaga gtgtgcatag 252481 caactaacta taattgaaca gggtgtttaa aacatggaaa aacaatacag agtattactt 252541 tactataaat atgttccgat tgaagatcca gaggcgttta gagagcagca tctggctttt 252601 tgtaaggagc ttggtttgtt aggccgtatc cttgtttctt ctgaaggaat taacggtacg 252661 gtatcaggta cggttgaaca gactgaaaaa tatatggaaa caatgaaagc tgatcctcgc 252721 tttgcggaca tggtatttaa aattgatgaa gcagaaggcc atgccttcaa aaaaatcttc 252781 gtccgccata aaaaagagct tgtaacgctt cgtcttgaag atgatgtcga tccgaacgaa 252841 acaacaggcc agcatttgaa gcctgcagaa ttttatgaga agatgcagga tccaaacaca 252901 attgtcatcg acgcgcgtaa cgattacgag tatgaccttg gccatttcag aggtgcggtc 252961 cgtcctgaca tcgaagcctt ccgtgaatta cctgaatgga ttgaagagca caaagatatg 253021 cttgaaggca aaaagatttt aacgtactgt acaggcggcg tgcgctgtga aaagttctca 253081 ggatggctgg tgaagcaagg ctttgaagat gtagctcagc ttgatggcgg aatcgtgaca 253141 tacggaaaag atccagaggt gcaaggcaag ctttgggacg gccagtgcta cgtatttgat 253201 gaaagaatca gcgtgcctgt caaccgtgtc gagcatgtga ttgtcggcaa ggactacttt 253261 acaggagaac cgtgtgagcg ttatgtgaac tgcgcaaatc catcttgcaa taaaaaaatg 253321 atatgcacac cggaaaatga gtataaatat atgcgcagct gcagccacga atgccgcacg 253381 aacccaagaa acctgtatgt gaaagagcat aatatgacag aagaagaagt aaacgcaaga 253441 ctggcagcga ttgaaacaga agatcacgct gctgctgaat aaaaaaagaa cacctcgtat 253501 tgaggtgttc tttttttcta tatgctttca gtttggctgt ttgcggaaac ccattctttt 253561 tggcggaagg ccttttccca ttttgatacc acgatacagg cgatcgcatg tcccggtacg 253621 ttcacgcctg ttctcgccat gtccatgacg cggtcaacac ccgcgataat ggcaacgcct 253681 tcagccggca gtcctacagc attggcagtc gccagaagaa ctacaagcga tcctgagggt 253741 acagctgcaa tgcctttact ggtcatcaca agcacaagca tcatgagcag ctgctgggac 253801 aatgtcatgt ctacttgaaa ggcctgtgcg agaaagatac aagaaaccga taaatataag 253861 ctggagccgt cacagttcaa tgacaagccg gagggaacga caaatgatac cactcgtttg 253921 ggacagccgt atttctccat tctatccatc agctgaggga gaatggtttc agtgcttgtg 253981 gtggaaaatg caattaaaaa cagatcccat atcattttca atacttcgaa atacttaatc 254041 tgaaagatga gaccgacaag cggaaagagg acaaagagga tcaggaacag gccaaggaat 254101 acggtgccaa ccagcttaaa catagggagg aggagttcaa tgccatattg gcctacagaa 254161 gcagccatca gggctaacac gccgatagga gcagtgacca tgacgatttg cgtgagcttg 254221 aacataatct gagctgtaga ttcaaaaaac ttcattactg gttcagaagc tttgccgata 254281 ccagctgcgg cgacaccaaa taaaatggcg aagaaaataa cggcaagcaa atcatttctg 254341 gccatgacat caataatgtt tgtagggata atatccagga tcatttgctt gaaatcaaca 254401 actttgtctg tgtagccgga aagttcatga atatcttttt ttgccaaatg ggagaggtca 254461 agcccgacac ctggttttaa gacattcgct aataaaagtc caagccctaa taccaacgtt 254521 gtaatcactt cgaaccaaat gatcgtcttg atgccgagac tgcccatttt tttcatgctt 254581 ccgcttcctg cggctccaat gacaatggta gaaaatacaa tcggcacaac aatcatttta 254641 atcaggcgga taaatccatc tccgacaggc ctcagtgcca tcccgaaatc aggaaaaaag 254701 tggccgatca ccgcgccgac agccaaagcg attaaaattt gaaacgcgat taattttttc 254761 aaatgaatcc ccctttagaa cgatagaatg taggcatatt catatcattc gtgattcaaa 254821 tgcaaacacc ttttttcaag ttattttatt ttgacagcgc tttcattatg ttggcgaaaa 254881 agtcccccgc agcagggggg acttttttac ttcatttgaa tgtgctttag atcttcttca 254941 gaggtatttg tgaaaataac cggtgttatg gctgaagcgg catgctgctt gatgtaattg 255001 agatcaaagg tgagaagcag ttcgccttgt ttgacggctt gtccgcttgt gacatgtgct 255061 tcaaagcctt ccccattcag tttgacggta tcgatgccga catgaatcag gatttcagtg 255121 ccgccggcgc tcataaagcc gatggcgtgt tttgtcggaa aaatcgagac gatctcgccg 255181 tccgcaggtg caacgacttt tccttctgat ggtataatcg caaatccctc gcccatcatt 255241 ttttctgaaa agacctgatc aggcacatcc cctaaagaga ctgtttctcc tttaatcgga 255301 taaataaagg tctcatcgga atcgggcttc agcggtttgt cagttaccgt gtccagcgcg 255361 gcggcggtgg cagggacgcc tccggccatg attgttttga tgtcgtcttt taaggcatcg 255421 gacttggttc cgaatattgc ctggaagttg ttgttgacct ccagcacacc tactgcacca 255481 agccgtttta attcatcctt gcagacttgg cttggctgat gaacggtcac acgaagcctt 255541 gtgatacatg catccaggtt agcgatattt tgctgtccgc ccaaggcctg cagcacgtga 255601 aaggcaagct ggtcttttgc aactggagct ttctcctcat tctgaccgtc ttcatctgtc 255661 tcacggccgg gcgttttcaa attccatttc agaatcgcaa atcggaacaa ataataataa 255721 atgaaagcaa acacgatccc gacaggaatg acaacccagc cgtttgtaga cagtccgtag 255781 ttcaagacgt agtcaattcc tccgcctgag aacgtatagc cgtggcggac atggaataaa 255841 tcacaaacga caaagatgac gccggcaaga atagagttaa tcaaatagag cacgggcgca 255901 acgaacaaga aagaaaactc aaccggttct gtaattccgg tcagcataga tgtgagcgcc 255961 gcagaaatca tcacgccgga gatcattttt ttcttttccg gacgcgcggt atggataatg 256021 gcaagagcaa cggccggcag acagaaaatc atgtaaggga aatcccccat cataaagcgc 256081 ccggctgtcg ggtctcccgc gaaaaacctt gtcaggtcgc cggttacggt gttgcctgtt 256141 gatgggtctg tgtattctcc catcataaaa tagaaaggcg tataaaaaat atgatgcagg 256201 ccaaaaggaa tcagcaaacg atagatcgtt gcataaaaga acaggccgac tgttgaatcg 256261 gcaattaaac tgctggctgc gttaattccg ttttggatca gcggccaaac gaatgagaaa 256321 atgacgccga tcaccaatga actgacggaa gtaatgatcg ggacaaagcg ttttccagag 256381 aaaaatccaa ggaccggatg cagctcgatt gatgaaaatc gcttatataa ataggcggcg 256441 agaagcccga taatgattcc tccgaaaacc cccatatcaa tcaggtgctc ggctccttca 256501 tacggaggct gaaggccgag taattttccc atattgtcga gggtgacggt taaaattaag 256561 tatccgatga cagcggcaag tccggctaca ccttctccgc cggctaatcc gatcgcgacc 256621 cccacggcga aaatcagcgg aaggttatcg aatacaacgc cgcccgcatc ctttataata 256681 gggatgttca gtaaatcctt gtctccgaaa cggagcaaaa gacctgctgc cggcaggacg 256741 gcaaccggag tcatcaacgc gcggccaagc tgctgcagaa tttgaaatgc ctttttaaac 256801 atgacagtct ccttttattg tgttatgaga atgatgcact ctttaatttt tgagctgctt 256861 tataatcggc gataacggtt acatgattgt gtttttgaag aatggaggct ggtacatctg 256921 tcgtgacagg accttcagcc atcttttgaa tggcgtctgc tttttcctcg ccgcttgcta 256981 aaagcacaat atgtttgctg aattccatga tggttttaat gcccattgaa atcgcgagtc 257041 tcggaaccag caccggatcg ccgccgaaga atctggcatt tgcctgtatc gtgctttccg 257101 agagcttcac aacacgtgtc cggtcttcaa aatcagatcc cggttcatta aaaccgatat 257161 ggccattggc gccgatgccg agaatttgga catcaatgcc tcccgcctgg cggatgagat 257221 cctcgtatac tttgcatgcc gcctcaagct gcggattgtc tccttgcggg atatgaatat 257281 gatcaggctg catattgata tgctgaaaaa gatgctcatg cataaaatgg ttataacttt 257341 gcggatgaga tggagagaga ccagcatatt catccaaatt aaatgtagta acctttgaaa 257401 aatcaatttc gcctgcctga tagtctgaaa tcaactgctt atacaagccg accggtgtgc 257461 ttcctgttgc caggccgaga acggcatctt tcttagcttg tatttgttct ttaataatgg 257521 cagcgcttaa cttacagagt tcttcgtagt gctcggcgat cagaatcttc atgtgacacc 257581 ccctcaaaga gatagacaag caccatattt gttatgacca atttatgata cttgtcatta 257641 cgaatttagc accgccctta tcaaactgtc aatattaatt tctgaaaatt tgttataaaa 257701 gaaggataca aatctttcat attgggaggg caaatggtat tatggtctca atgaaaaaga 257761 acggattgca tacagaatgg ggagaatgaa atgacagctt tatattctgt tatcaagttt 257821 aaaatcattg agttaattaa atcgggcaaa tatcaggcga atgatcagct gccgacggag 257881 agtgagtttt gcgaacaata tgatgtcagc agaacaactg tgagactggc tctgcagcag 257941 ctagagcttg agggatatat taaaagaatt caaggaaaag ggacatttgt atcggcggcc 258001 aaaatacaaa cgccgattcc gcataagatt acgagctttg cagaacaaat gagaggactt 258061 cgttctgaat caaaagtgct tgagcttgtg gtgattcctg ccgatcattc catcgccgag 258121 cttttgaaaa tgaaagagaa tgaacctgtc aacaagcttg tcagagtcag atacgccgag 258181 ggggaacctt tgcagtatca tacctcatat attccctgga aggcggcacc ggggctggcg 258241 caggaggaat gcaccggctc gctgtttgaa ttgttaagga caaaatacaa tattgaaatc 258301 agcaggggca cggaatcgat cgaaccgatt ttaacggatg aaacgatcag cggacactta 258361 ttaaccaatg tcggagcgcc tgcgttttta tcagaatccc ttacctatga taaaaatgaa 258421 gaagtggtgg aatatgcgca aattattaca cggggagacc gaacgaaatt caccgtagaa 258481 cagtcatatc attcataaag caatgtgttt taagaaggga atggtggttc tatgttttta 258541 tttacgaatg gaaaagtgct gtggggagca gtgattgctg cattcatcct ttcaattgta 258601 ttttaccctt ttctgccgac gcagatgccg attcattatg atgttgcgaa cagtccggat 258661 ctgacggtta acaagctggc ggggactgtg atgctgcctg ttttgatggt ggtgtttgca 258721 tgggcgcgga agatcaattg gcaatttgta ttcgcagtgt atattttgct gatttgccac 258781 attgtcgtcc tttgtttagc gctctaaatc aaacagccag aataaaactg gctgttttct 258841 ttaatttcag cttcatctga caatgaatgt ggtgtataat agctgatgat cctaaagaat 258901 attctgaaat ttataggtgt gaagcggcgt attattaaag gaaaggctgt atactttttg 258961 cagctttaaa aagactgaat atttaaacaa ttatgtgaaa ggtgtgctga ttagattgaa 259021 taagcttatt gaacgagaaa aaactgtata ttataaggaa aagcccgacc cgtcttcctt 259081 ggggtttgga caatatttta cagattatat gtttgtgatg gactacgaag aggggattgg 259141 atggcatcat ccgagaattg cgccgtacgc accgcttacg cttgatccgt cttcatctgt 259201 ttttcattac ggccaggctg tttttgaagg attaaaagca tacagaacag acgacggcag 259261 ggtgctgctg ttccgtccgg atcaaaatat caaacggctg aacagatcgt gtgagcgcat 259321 gagcatgccc cctttagacg aagagctggt gcttgaggca ttgacgcaat tagttgagct 259381 ggagaaagat tgggttccaa aggaaaaagg aacgtcactg tatattcgtc cttttgtcat 259441 tgccacagaa ccgagtctcg gtgtgaaggc atccaggagc tatacattta tgatcgtgct 259501 ttcgcctgtc ggctcctatt atggcgacga tcagctgaag ccggttagaa tctatgtcga 259561 agatgagtat gtgagggcgg tcaacggagg agtcgggttt gcaaaaacgg ctggaaacta 259621 tgccgccagt cttcaggcac agcggaaagc gaatgaactg ggctatgacc aggtactgtg 259681 gctggacgcc atcgaaaaga aatatgtgga agaagtaggg agcatgaaca tctttttcgt 259741 cataaacggg gaagctgtca cacctgcttt aagcggaagc attttaagcg gggttacacg 259801 tgcgtctgcg attgaattga ttcgaagctg gggcattccg gttcgtgaag agagaatatc 259861 gattgatgag gtgtatgcgg cctctgcacg cggagaattg acagaggtct ttggcacagg 259921 cacggcagca gtcgttacgc ctgtcggtga actcaacatc catggaaaaa cggtgattgt 259981 aggcgacggg caaatcgggg acctctcgaa aaagctgtat gaaacgataa cagatattca 260041 gcttggcaag gtaaaaggcc cgtttaactg gacagtggaa gtgtgaaaat cgaaaaagaa 260101 cctgcccgga ggcaggttct ttttattttg aatgagtcat atcagcagcc ggctggcttt 260161 tgcggttttt tacataatat attgcatagc aaatggccat aaatggaacg ccgcaataga 260221 gtgcgattct ttgattcgga tcaaaggcaa tgccaacgac ggaagccagg cataacagga 260281 acgcagcaat cggcacgaac ggatacaaag gggttctgta tttcaaatca gtaaccttgt 260341 ttcccgcttc gatataacgt tttctgaaca tgaattgaga agcagcgatt cccatccaca 260401 cgacaacgac ggcaaaaccg gaaatcgaca cgagcacaac gtatacagtg tctggcgcaa 260461 atacgctgga cagcaacgac agaatgccgc cgatcatgct gaacaccagc gcgttaaaag 260521 gggttccttt tgacgtcagc tttgcaaatg tcggatgaag cgttttttct tttgataaag 260581 accacagcat ccgggaagaa gcgtagagtc cggaattagc cgctgacagg atcgctgtca 260641 ggataacaaa gttcatgata tcggctgcgt atggtacacc gactctgtca aagacagcga 260701 caaacgggct tttgatgaca cctgcatctt gaatcggaat cagccctgac agcacaaaaa 260761 ttgttccgac aaagaagagc gagagacgcc agaccgttgt ttttatcgct tttggtatcg 260821 tcttgtcagg atcaacgctt tcaccggctg cgattccgat tagttccgtt cccgaaaagg 260881 caaaattgac ggacagcatc gtcatcaaaa tcgggacaaa tccattggga aaaagcccgc 260941 cttccgccgt gaagttggac agcatcggag cggcttctcc gcctttgatc gggatgatgc 261001 cgaacatggc agagccgcct aaaagaataa ataatacaat ggctaatact ttgatgctgg 261061 aaaaccaaaa ttctgattca gcgaaaaact tgaccgaaaa tgcgttaagc aagaagatga 261121 acagcgcaaa gacggcactc cacatccaaa ccgatgtatg ggggaaccag cgctgcatta 261181 acaggccggc tgctgtgaat tctgatccca atgccacggt ccatgtcagc caatacagcc 261241 aagcgaccgt aaatccggtg cccggcccta tgtatttggc tgcataggtg tgaaaggcgc 261301 cggtcacagg catggcgact gacagctcac cgaggcatag catgaccaga tagacgatgc 261361 cggccccgac taagtaggcg agtatcgttc cggccgggcc tgcttgctga atggtataac 261421 ctgagcttaa aaacagcccg gttccgatga cacctcccaa ggaaagcata aagaggtgcc 261481 ggcttttcat acttctctga aaggttgtct cattcttgtt gtgggcagag ttcatctttt 261541 tccaactttc tatcagcgat ttatttcctt cctaataaaa aatctcatgt cagaaagtga 261601 cacgagactc cggcgaaccg gctttaagtt agaatataca aactattccg ataagtcaag 261661 ttgtttttaa agagcgggcc caagccgcaa tttcttgaat attttcgggt tttgtccggc 261721 agcagccgcc aatcagcctc gctccttttt catgccaggt gcgggcgctc gccccgtaag 261781 attctgcgca tgctgcgccg ttccacgttt ttgtttccgg atcatattgc tcacctgaat 261841 tcgggtagac aatgatcggt tttgacgtgt tcttttttaa ctcctctatc aaggaaggga 261901 tatgctgaag cggcgtgcag ttgatgccga gtgctgcaat ttggcggtgt tcatcaagcc 261961 acgatgcgca gtcagctgca ggtgttccgt cactgatatg caagccgtct ttagcactga 262021 agctgatcca tgcatacgtt tcaggaaatt ccttcaacag ccgaacaatc gctttggctt 262081 cagtcagaca cggaatcgtt tcgcatgcca atacatcagc tccggcttca atcagcgcct 262141 tcatccgggg gcgatgaaat tcaatcagtt catcttctga tattgcgtag ttgccgcgat 262201 actcagaccc gtctgcaaga taagcgccat aagggcctat agaagccgca atgatcggtt 262261 ttggccgatt caaacggttc tcttcaagcg accaaaattc atcacgtgct tcagctgcga 262321 tgctgacgga caactcgatg agccggcgtg cttccgcttc gctcagcccg cgtgcggcaa 262381 agccttcaaa tgtagactga tagctggcgg tgattgcaca atcggcgcct gccgcaaaat 262441 aatcagtatg aacttgttta atcagctccg gctcttccat caggattttt gccgaccaca 262501 gactgtcatt caaattacag cccttgcgtt caagctcggt cgccatggcg ccgtctagca 262561 caataagcgg gtatgtatct aatatgtgtt ggataggatt catagaatgt accgatgcct 262621 tctttcagat ttttttgaaa aagatatgaa aatcgtaatg gaggcttacg tgtttgtcaa 262681 taaacgcaaa aagagaaagg tgttcagccc atatgtctga acaccctttt cttatgatat 262741 ttgtttgttg tgcgtgtcag tctttgtgtc tgaaaccggc cagcactcaa tgccattatg 262801 gtttttgagc acatctttat aaaagaccgg atccttgcct gcttttttct ggcgtgtata 262861 gtctttcagc gccgtaaaaa cgacctttga tagtaagaaa atcgcgatta aattcacgat 262921 gaccatcaaa cccatgaaca aatcagcaag atcccagacg agctggactt tggcaacaca 262981 gccaaacacg atcattgcca gcacgccgat acggtagaca aaaatcagtt ttttgctttt 263041 gttcaaaaag ccgatattgg tttcgccata ataatagttt ccaattagag cacagaatcc 263101 gaataacaaa atcagaatcg cgagaaagcc tgatgcccat gatccgacat gggagctgag 263161 ggaggcttgt gtcaaggcga ttccgctcag acccggagta tgataggcat ccgaaaacag 263221 aatgataaaa gcggtgcttg tacaaatgac cagtgtatct gtcagtacac caaaagcttg 263281 gatcagcccc tgtttgacgg gatggcttgt tgtggcggtg gcagcggcat ttggtgcgct 263341 tcccattccc gcttcgtttg aaaagattcc ccgtctgacg ccttgcatga gtgccgcgcc 263401 caaagccccg ccggcggcct ggtcaaaacc aaacgcattt ttcacgatta gcgcaagcac 263461 acctggcagc tgcgtaatgt tggagaaaat gacgaaaaac gcaactccga tatacaggac 263521 agccaatacg acgacaatgg attcagccag ctttgcaatg cgcttgactc cgccaaaaat 263581 aatcgtgccg aatacagcaa ttaaaatgag tcccaatgtc aggcggtttg tgccaaacgc 263641 gttttcaaag gcaaggctga ctgtattgga ttgaaccgag ttgaagacga taccgaacga 263701 taaggtgatt aacacagcga acagcgcgcc catccacctt ttgttcagcc ctttttccat 263761 gtaatacgcc ggcccgccgc ggaagccgtt tacatctttt actttataaa tctgagccag 263821 tgtgctttcc acaaagctgg atgctgatcc gataatggcg ataatccaca tccagaagat 263881 tgcaccgggc ccgccgagtg caatggcgat agcaatgccc gtaatatttc ccgttccgac 263941 acgggccgcc atgctgatgc aaaaggcttg aaacggagaa atgctgtttt ttgaccggga 264001 agcagcacct tctcttaata ccctgaccat ttctttcagc atgcgaacct gtaaaaactt 264061 aagcctgaac gtaaaataga ttccaaaaga aaggagcaaa acaattaata gctttgacca 264121 caaaagatca tttgcaatac cgacgatatg ttctaggatt tgctgcatag aatcacctct 264181 tttttcatgt ttaaaaaatg ctgagctccc attcctgcgc catatgcttc agcagcatac 264241 cgccagtgag gctgttgccg tattcatcaa tggcaggccc gtaaatgccg atgccgcatc 264301 cggattgaaa aggctgttct cttctggcgc ttggaggcac cagcgccatg atgccgccgg 264361 agacgccgct tttggccggc acgccgacaa acgccgcata tttgcctgaa gcgttgtaca 264421 tgccgcacgt cagcattaat gccttggcca attttgccac atcttttgga atcacctgct 264481 cgtgtcgaat cggatgatac ccgtcatgag caaggatcag gccgatcaac gcaatatctt 264541 ctgtagtgct ctccatagcg cattgcttca agtacacctc aagtgtttct tctacttcag 264601 cttctaaaaa gtttgtttct tttaaatagt aggccagcgc tctgttgcgg tgggcggttt 264661 cccattcaga acggaatact tcttcatgaa ttcttggccg ttttcctatc aaagtttcca 264721 tcaccgagta aagaaactcg agcttttcgt atgcagattc tccgggaagg atcgaagcga 264781 tggtgagggc acccgcgttg atcatgggat tgaagggctt tcccggcttg ttgatttcga 264841 gccgaatgat tgaattaaag gcgtcacctg tcggctcgac atctacgcgg tcaagcacat 264901 agggaatgcc gcggctcatg caggcggcaa taaagctaat cacttttgaa atgctttgca 264961 tggtaaaaga gacgttccag tcgccggcgt gtatcatcgt tccatcaggc tccaatacac 265021 agatgccgag ctgtgaatca ttgacttttc ctaaagcggg gatatagttt gcgctttgtc 265081 cattggcggc aaaagggcga tagtattcaa cccaatcatg aagctgtaac gccgggttta 265141 tgtctttctg gtgctctttt atcaattctt tcatcgaatt cctcctcact gatttttttc 265201 ttaaaggact gaggtgtatc aaaacgaagg ctaagggggc gttaaacgct ttcataatag 265261 cggaaggtat aattactgta taatggagac tacagaatca tacaaaatac gacaaaaaca 265321 ttttgaaaat aagcagtaag atttataaaa acctcatgtt ctgggtcaaa agcaatttgc 265381 aggttttctc ccgattcccc aaaataaaaa gcgaggatgt gatcaacata aaactggaac 265441 ggtttattga aaaagacgga tatatactgg ccctcatgct gattacggtg ccgctggccg 265501 gtgaactgaa attttatccc ctcaatgaag aattccgggt cagctttggg gcaccggttt 265561 ttttcttctt tttatcattg ttgcggcatg tgcccgctgt gctgccgggt tttctgactg 265621 gagcggctgt tttcatcttt cgcgtctttc tggaattatg gggcggagga cacaatgggc 265681 tgactccgat tctgtatgat caagcgtctg gctttttctt ttatatgact tacgcctgtc 265741 tgttttccat attaaaggcc aatcgtttcc gtgaacggcc gattatgctc ggtttcattg 265801 ggtttatgat tgaagttgtg tcagattgtg tcgagctaac tgtgcaattt ctcatttttc 265861 atacggttgt cacgcctgag aaaatcactg acattgcggt gattgcgatt tctcacacat 265921 ttattgtgat gagcttttat agtgtgctga agctgtatga aacacaatcg agagaaaaac 265981 agacaaggca gcagcacgag cacatgctga tgatcgtttc caatttatat gaagaaacgg 266041 tgcacctaaa aaagacattg aaaacgacag agaaagtgac aaacgattcg tatcagctct 266101 atcgggaaat gaagggcaag gatgttcagc tgagcggcag aatcctgaga ctggccggag 266161 agattcatga agtgaaaaag gacaaccagc ggatattcgc agggctttca aaactgattt 266221 cgaatgagag tttgagagat tatatgaggg cttctgattt gctgcagctc gtgattcgaa 266281 tgaatgaaaa gtacgctgaa gcactaggga agcagattga tttttactgc tcgatcgagg 266341 gagagcatga cgaatatcac gtatttatcg tgctttcgat cattaataat ctaacagcaa 266401 atgcggtaga ggctatggat gaagagggaa tggtcagcct gaggctccgt aagccaaatg 266461 agagtatggt agaattccag gtggaagaca atggccccgg gatttccgag aaaatcggag 266521 acattgtgtt tgacccgggc tttacttcaa aatatgacga atttggcacg ccttctacgg 266581 gtatcggact ttcctacgta aaggaaatcg tgacagagct agaaggggat atcacgtttg 266641 ataatcagca gcggggagtg gtgtttgcca tcaggctgcc tgtccggcat ttgattcaga 266701 aagggtgaac caaaagctat gcgttttttt attgcagatg atgaccgtgc ggtgcggtca 266761 attttaaggc agatcattga ggacgaagat ctcggggaag ctgctggtga agcagacgac 266821 ggaagccaag tggaagggca tatgctgcaa tttaagcaga ttgatatttt attaatcgat 266881 ctgttaatgc ccggaagaga cggcattgag acgattcgtc agatccagaa tacgtactcc 266941 ggcaaaatcg taatgatctc tcaagtggag gcgaaggaaa tggtcgggga agcgtactcg 267001 ctcggcatcg aatattttat ccataagccg attaaccgca ttgaaattgt cacggttctc 267061 caaaaggtga aggagcggat cgagcttgaa cactcgattg gagccattca gcattctcta 267121 agccggcttg tcaatcggac tgaacggaaa gcgcgtcccc agcagaagag tgacagcggt 267181 ttaaaagagg caggaacatt cctgttgtcc gagctgggca tgatgggaga aggcggcgca 267241 catgatctca tggcggtcct gcagtattta gcagaacacg agcaatccga gccgcacgaa 267301 aaacaaagcc cttcgctaaa acaaatattc acccaagtag cggtacggaa gctggggaca 267361 ggagcctcac agacggaagt caatcgcgaa atgaaagcct cggagcagcg tatccgcaga 267421 gcgattattc attcgctgca ccattttgct tcactgggca caactgattt ttcgaatcca 267481 aaatttgaaa cctatgcatc gaaattcttt gattttccgg ttgtcagcca gaaaatgaaa 267541 gaactccaat ccaaggatgc aaaacccctt gcacctgcta gaataaatat gaaaaaattc 267601 atccacgtgt tttttttgga agcaaagctt ttgcatgaga cgatgaaaca aagaaggata 267661 taaaccaaac agccggctga ccaggctgtt tttttgctgc gcagaatccc ggccggacag 267721 tgatttaccg cttttttata aaatatcaga aaataaagat attgacttat tgtttatttg 267781 tcttacaatt aaacaaaagg atatatggga aggagcggat gtgaaagaaa aattaataaa 267841 agcgcttaca gatagaggcc gtatacacaa ataacaggag gttatgttga tgagccgtat 267901 cagaaaagca cccgctggaa ttttaggttt tccggttgct ccttttaaca cacaaggaaa 267961 actggaggaa gaagctcttt ttcaaaacat tgagtttttg ctgaatgagg gcttggaagc 268021 gatatttatc gcttgcgggt ctggtgaatt ccaatctctc agccagaagg aatatgagca 268081 aatggtggaa gtcgcagtct cggcagccgg aggaaaggtg ccggtctaca cgggggtggg 268141 cggcaacctc agcacagcgc ttgattgggc gcagctgtcg gagaaaaaag gcgccgacgg 268201 ctacttgatt ctgcctccgt atttggtgca tggcgaacag gaggggctgt accagtatgc 268261 gaaaacgatt attgaaagca ctgacttgaa cgcgattctt tatcagcgcg ataacgcagt 268321 tctctctgtt gaacagatca aacgtctgac cgaatgtgaa cagcttgtcg gtgtcaaaga 268381 cggggtagga aatatggatt tgaatatcaa tctcgtctat acgatcggcg accgcttggg 268441 atggctcaac ggaatgccga tggctgaagt gacgatgccg gcttatctgc cgatcgggtt 268501 ccactcttac tcttcagcga tttcaaatta tatcccgcat atttcgcgaa tgttctatga 268561 tgcattgaaa aacggaaatg acgagcttgt gaaggaactc tatcggcatg tgattctgcc 268621 gatcaacgac attcgcaaac aacgaaaagg ctacgccgta tccttgatta aagccggtat 268681 ggaaatcatg ggtttgaatg taaggaatac agccagaccg cctgtcggcc cggttgaaaa 268741 agatcattat cagcaattgg aagcaatttt gaagcaggcg gctgaccgtt ttccgaaaaa 268801 agccgcgacg gtttgaccag aaaaaacacg aaaggggcaa tgggcatgtc tgtgatcacg 268861 gaacaaaaca cgtacctcaa ctttattaac ggagagtggg ttaagtctca atcaggcgat 268921 atggtcaaag tcgaaaaccc tgccgatgtg aatgatattg tcggatatgt acagaattca 268981 acggctgaag atgtggaacg tgccgtcacc gccgccaatg aagccaaaac ggcttggaga 269041 aagctgacgg gtgccgagcg cggccaatac ttatacaaaa cagcggatat catggagcag 269101 cgcttggagg aaatcgccgc ctgtgcaacg cgtgaaatgg gtaaaacatt gccggaagcg 269161 aagggagaaa cagcccgggg gattgccatt ctgcgctatt acgccggaga gggcatgcga 269221 aaaacgggtg acgtcattcc gtctactgac aaagacgcgc tcatgtttac cacccgtgtt 269281 ccgctcggtg tggtcggtgt gatttctccg tggaacttcc cagtggcgat tccgatttgg 269341 aaaatggcgc cggcattggt atacggcaat accgttgtca tcaaaccggc gacagaaaca 269401 gctgtgacat gcgcgaagat cattgcctgc tttgaggaag cggggctccc ggcaggggtc 269461 atcaatttgg tgacaggccc gggttctgtt gtcgggcagg ggcttgctga gcatgacggt 269521 gtaaacgccg ttacgtttac cggttcaaat caagtcggaa aaatcatcgg gcaagccgct 269581 ttagcgaggg gagccaaata tcagcttgag atgggcggca aaaaccctgt catcgtagct 269641 gatgacgctg accttgaagc tgcggcagaa gctgtcataa cgggggcctt ccgttcaacc 269701 ggccagaaat gcaccgcgac aagccgtgtc atcgtacaaa gcggaattta cgagcgcttt 269761 aaagaaaaac tgctccagcg cacaaaagat attacaatcg gagacagctt aaaagaggat 269821 gtctggatgg gaccgatagc cagcaagaat cagcttgata actgcctgtc atacattgag 269881 aaaggcaaac aggagggcgc ttccctttta ataggaggag aaaagctgga gaacggaaag 269941 tatcaaaacg gctattatgt tcagcctgcc atctttgaca atgtgacatc tgagatgaca 270001 attgcccagg aggaaatttt cggtccggtg atcgccttga tcaaggtgga ctcgatagag 270061 gaggcgctga acatcgccaa tgatgtgaag ttcggtttaa gtgcatccat cttcacggaa 270121 aacatcggcc gaatgctttc tttcattgat gaaatcgatg ccgggctggt tcggatcaat 270181 gcagaaagcg caggtgttga gctgcaggcg ccttttggcg gcatgaagca gtcgagctcc 270241 cactcccgag aacagggtga ggcagcgaag gactttttca cagcgatcaa aactgttttt 270301 gtgaagccgt aatggtgctg gaaagaggcg tgcgtctctt tcccggttta tcacaaccag 270361 catatgattc tctactttga aaaggagaag atactatgaa aaaagacttt gcgagtgtta 270421 ctccggcggg caaaaaaacg tccgtgcgct ggttcatcgt gtttatgctg tttcttgtga 270481 cctctattaa ctacgcggat cgagcgacgc tttccatcac cggagattcc gtccagcacg 270541 atttgggatt ggactcggtc gccatgggat atgtcttttc tgcctttggc tgggcctatg 270601 tcatcggaca gcttccgggc ggctggctgc tggaccgttt tggttcaaag actatcattg 270661 cgttaagcat ctttttctgg tcgtttttta cgttgctgca aggggcgatt ggctttttct 270721 ccgccggcac agcgattatc ctgctgtttg cactgcgttt tctggttggt ttatcagaag 270781 cgccttcatt tcccggaaac ggcagagttg ttgcctcatg gtttccaagc tccgagcgcg 270841 ggacagcttc agcctttttt aattcagcac aatacttcgc aatcgtcatt ttttctcctt 270901 taatgggctg gcttacccac tctttcggct ggcattccgt tttcgttgtc atgggtattg 270961 caggcattct tctggctgtc atctggctaa aaacggtgta tgaaccgaaa aaacatccga 271021 aggttaatga agctgagctt gcgtacatcg aacagggcgg cgggctgatt tccatggatg 271081 acagtaaaag caaacaagaa acagaatcga aatggccgta tatcaaacag ctgttaacga 271141 accgcatgct gattggcgtg tacatcgcgc aatactgtat tacgactctc acctatttct 271201 ttctcacatg gtttccggta tatttggttc aggcccgcgg catgtctatt cttgaagctg 271261 ggtttgtcgc ttccctgccg gcgctgtgcg gatttgccgg cggcgtgctt gggggcattg 271321 tgtcagacat cttactcaaa aaaggccgtt cactgacctt tgcaagaaaa gtgccaatca 271381 ttgccggcat gctgctgtct tgcagtatga ttgtctgtaa ctacacagat tcagcatggc 271441 tcgtcgttgt cattatgtcg ctcgcgtttt tcggaaaagg cttcggcgca ttgggttggg 271501 ctgtcgtgtc ggacacgtct ccgaaagaat gtgcaggatt aagcggcggt ttgttcaaca 271561 ctttcgggaa tattgcctca attacaacac cgattattat cggatacatt gtcaatgcca 271621 ctggatcttt caatggcgcg cttgtgtttg tcggcgctaa cgcgattgcg gcgatcctca 271681 gctatttgct gctggtcggg ccgatcaaac gggtcgtgtt aaagaaacaa gaacaagacc 271741 ccgatcaatc gttgcctgtc taatatttat gaaagcgctt tataaaggga ggaaaatgca 271801 tgagttcacc gatacaagag caggttcaaa aagaaaaaag atcgaatatt ccctcaattt 271861 ctgaaatgaa ggtgattcct gttgcgggac atgacagcat gctgctgaat ctaagcggag 271921 cacacagccc gttttttacc cggaatatcg taatcttaac agacagcagc ggaaatcagg 271981 gagtcggcga ggtgcctggc ggagagcata ttcgccgcac actggagctg tcagagccgc 272041 ttgttgtcgg aaaatctatc ggtgcgtacc aggcgatatt gcaaacggtc agaaagcagt 272101 ttggcgatca ggacagggga gggcgaggaa accagacgtt tgatttgcgc accactgtgc 272161 acgccgtcac cgcactggaa gcggctttgt tggatttgct tggaaagttt cttcaggaac 272221 cggtcgcggc tttgctgggc gaagggaagc agcgtgatga agtaaaaatg ctcggttacc 272281 tcttttacat cggcgaccga aatcggacga ccttgccgta tcaaagcgat gagcagtcag 272341 attgtgcgtg gttccgtctg cgccatgagg aagcgctgac gccggaggcc attgtgcgtc 272401 ttgccgaatc cgcacaggag cgctatggct ttcaggattt caaattgaaa ggcggggtgc 272461 tgcggggaga agaggaaatc gaagctgtta ccgcattatc gaaacgtttt ccagaggcaa 272521 ggatcactct tgatccgaac ggggcatggt cattagagga agctattgca ttatgcaaag 272581 gaaagcaaga tgtgctcgcg tatgcggaag atccatgcgg ggatgagaat ggctactccg 272641 ctcgtgaagt aatggctgaa ttccgccgcg cgacagggct tccgactgcg acaaatatga 272701 ttgcgactga ctggcgggaa atgggtcacg cgattcagct ccacgcggtc gatataccgc 272761 tggctgatcc gcatttttgg acgatgcaag ggtcggtgcg ggttgcgcaa atgtgccatg 272821 attggggttt gacatggggc tcgcactcca acaaccactt tgatatttcc cttgcgatgt 272881 ttacccatgt ggcagcagcg gctccggggc ggatcacggc gattgatacc cattggatct 272941 ggcaggacgg gcagcgatta acgaaacagc cttttgagat ttcttctggc tgtgtcaagg 273001 tgccggataa gcctggacta ggcgtcgata ttgatatgga acaagtggaa aaagcgcatg 273061 agatctatcg gaaaatgaat ttaggcgcac ggaatgatgc gatcccaatg cagttcctga 273121 tcagcaactg ggaatttgac cggaagcgcc cgtgtcttgt gcgataagtt tgattgtaaa 273181 tattgtcata tccgctattt tgtcttacaa ttgaacaact gaagggagag ttgttcgtgt 273241 acgaaggttt agaggatttg aaagtcgata cagtcaatcg gaaaacatta gccaagcagg 273301 tcatcgaacg gattgtccat ttattatcga gcggacagtt gagggccgga gacaaattgc 273361 cgacagaaat ggaactgatg gacattttgc atgtcagcag gccggtgcta cgggaagcac 273421 tcagttcact tgaaacgctg ggcgtcatta cgagaaaaac acgagggggc acatatttca 273481 acgataaaat cggcatgcag ccattttccg tcatgcttgc tttggccact gataatcttc 273541 cggctatcat tgaagcgcgg atggcgctag aactcgggct cgtgacaatt gccgcggaaa 273601 aaatcaatga ggaagagctt cagcgtttgc agaagacgat cgacgatatt gccaacagca 273661 ctgacaatca ttatggtgaa gcggataaag agttccatcg aattattgcg ttaagcgcca 273721 ataaccccgt cgttgaaggg atgattcagt ccctgctgat cacccatgcg aaaattgaca 273781 gccaaattcc gtacagggag agagatgtaa cggtcgaata tcacaaaaaa atctacgacg 273841 cccttgccaa aagagatccg tacaaagcac attaccacat gtatgagcat ctgaaatttg 273901 tccgtgacaa aattctaaaa ggaatggatg aaaaataatg gtgagcaacc gcagttgaaa 273961 cgtaagagct gcggtttttt taaaccaatt tagaaaacgc ttactaaaat atgaggagtg 274021 attttcatat ggcgatgaac ctcaggaaga accaagcccc cctttacatc aaagtgcatg 274081 aaatagataa caccgcgatt attgtaaatg atggagggct gccaaagggc actgttttct 274141 catgcgggct cgtacttgaa gaggatgttc ctcaaggcca taaggtggcc ctcaccgatc 274201 tcaatcaagg ggacgagatc gtgcgttacg gagaggtgat cggatttgct gatgagacga 274261 tcaaacgcgg gagctggata cgggaagccc tcgtgagaat gcccgctcct ccggcgttag 274321 acgatcttcc tctcgcaaac agggtgccgc agccgcggcc cccacttgaa ggatatacat 274381 ttgaaggata ccgaaatgcg gatggcagtg cggggacaaa aaatatcctc ggcatcacga 274441 caagtgttca atgtgttgtt ggcgttttgg attatgcagt caaacgaata aaagaagagc 274501 tgctgccgaa atacccaaat gtcgatgacg ttgtgccgct gcatcatcaa tacggatgcg 274561 gcgtggcgat caatgcgccc gacgctgtca ttccgatccg cacgattcaa aatcttgcga 274621 agcatccgaa cttcggcggt gaagtaatgg taatcggatt gggatgtgaa aagctcctcc 274681 cggaaagaat tgcctccgaa aatgatgatg acattctatc gctccaggat caccgaggtt 274741 ttgcggcgat gatccaatcc attttggaaa tggcggagga acggttaatc aggctgaaca 274801 gcagaacccg ggtgtcatgc cctgtttcgg atctggttat cggcctgcaa tgcggcggca 274861 gtgatgcgtt ttccggcgtg acggcgaacc ctgccgtggg gtatgcggct gatttattgg 274921 ttcgcgcagg tgcaacggtt ttgttttctg aagtgacaga ggtgcgggat gccattcatt 274981 tattaacgcc gcgggctgtc agtgaagagg tcggacaatc gctgatcaaa gagatgaagt 275041 ggtatgacag ctatcttcgg cggggagacg cagaccgtag cgcaaacccg tcaccaggca 275101 ataaaaaagg cggattatcc aatgtggtgg aaaaagcgtt aggttcggta gcgaaatcag 275161 gcacaagccc catctccggc gtgctcggcc ctggtgaaag agcaaagcaa aaaggcctgc 275221 tgttcgcggc gacaccggca agcgattttg tgtgcggcac cctgcagctg gctgcgggca 275281 tgaatttgca ggtgtttacg acagggagag gaacaccata tggcctggct gctgcgccgg 275341 ttctgaaagt atcgacgcgg cattccttat cagagcattg ggctgattta atcgatatca 275401 atgccggccg aatcgcgaca ggagaggcca gtatcgaaga cgtaggctgg gaaatcttca 275461 ggacgatttt ggatgtggca agcggccgca aacaaacgtg ggcagaccgt tggggtcttc 275521 ataatgattt gtgcttgttt aatcctgctc cagtgacttg attcatgttt ttatagcgga 275581 aagatggaat atgctgtaaa atgaaaatca gcgtatagga aacggagggg ttacagcatg 275641 gcattcatta gattccgagt gacacgaatt caatagtgaa caactctcgc ctgaatgcga 275701 gagaatcggg atgaatccgc ctatgtatga gcccttatat ggttatcaaa aaagagggtg 275761 gcgtgcctgc ccttttttgt gccttcaagc atcccttctc tctactgcag gccggagcat 275821 gagaaagggg aaatgggatg acaaacctta acgaaaaaca gcttatcact gagattgtcg 275881 ggcttgcacg cagccaaggt ttgacggttc attctgagaa cgcgcaattg aatgaaaccg 275941 gaatggactt tcaagttgta tttgccaagg acgacacagg tatgccatgg gtgctgcgaa 276001 aaccgcggcg aagtgatgtt gtggaaagag catctgcaga aggcataacg cttgcctttc 276061 tccgcgcgaa tctgactgct gatgtgccgg attggagaat tcatacaccg gaattgatcg 276121 cttaccccat gttaaaagga acgccggctg ctggaattga cttggaacaa aagcaatatg 276181 tatggaatat ggatcatcag ccgccgtcag acgactttgt ccgcacactt gccgacatac 276241 tggctgaatt acatggcacg gatcaaatat ctgctgggca atccggaata gaagtgataa 276301 ggccagaaga tttcaggcaa atgacagcag actctatggt tgatgtgaag aataagcttg 276361 gcgtatctac gacgctttgg gaaagatggc aaaagtgggt agatgatgat gcatactggc 276421 cgggtttctc ttctttgata cacggcgatc tccacccgcc gcatatcctt atcgatcaaa 276481 atggacgtgt cacaggactt ctggattgga cagaagcgaa ggttgctgac ccagccaagg 276541 attttgttct ttatcaaacc attttcggag aaaaagaaac tgcccgtttg cttgaatact 276601 atgatcaagc aggcggccga atatgggcaa aaatgcagga acacatctca gagatgcagg 276661 cggcgtatcc ggtggaaatc gccaagctag ctctgcaaac acagcaggag gaacacatca 276721 atatggcgct ggaagcactt ggtgtaacat cggattaaga attgacttcg tttcatgaac 276781 cgagtattat aaactctaca aataatagaa cggattaaca atcgtgagga agagcaagta 276841 cgcatcagaa tggaggttca gagagtcggt ggcaggtgtg aaccgatcct cccctgatgc 276901 cgaatgggct tctgaattgc tttgctgaac ggatagtagg cgatgccggg tttctctccc 276961 cgttaccaag agaggagtat cgaaacatag gttttctgta cttagagtga acggctgtat 277021 agctgttaat aaaggtggta ccgcgagacc ctcgtccttt gcataggacg ggggtttttt 277081 gtgtttctta aaggaggtga cggccaatgt acgatggctg gtggtggcat agcagatgag 277141 ttagaaagga ggatatcaaa tggtcattgc aactgatgat cttgaggtcg catgtcctaa 277201 atgtgaaaga gcgggagaaa tcgaaggaac accttgcccg gcctgcagcg gaaaaggtgt 277261 tattctgact gctcaaggat atacgcttct cgattttatc caaaagcatt tgaataagta 277321 aaggagaaaa gctgagctga gatgagagca gaagagcaga gtaagattcg tgaggccgca 277381 gcaggtacga tttttttgct gatcggaaca gtttgttttg cgtctaaatc gatttggata 277441 aaatgggcat accaaatggg tgctgagcca gatgccgtgc tgctatacag gcagctgctg 277501 gctgttccgc tgttttggct gattttttta atataccgtc ctccaatgcc agacggtaag 277561 aaaaaaggag acctatggaa ggcttgtggc gcgggagtgt tttgtttttt tctgtctccc 277621 ttgcttgatt ttatcgggct gaaccatgta tccgcaatgg ttgaacgtat attgctgatg 277681 agctatccgt tgtttgtgtt tggattcacc gcgtgtcgtg accggaaaat gtcctcaatt 277741 caggaccttt tcgcagttct ggcggtcatg tttgggcttt tcttggcgct gggcggctgg 277801 aatgctgagc ttttccaggc gaatatgatt ggagctgtat tcattttgtt atcttcggcc 277861 gtctatgctg gttatcttgt cctttccggg catctcgtcc atcaaatcgg agggatccgt 277921 ctcaatgcat acgggatgac agctgctgga gctgccatga tgctttacac agggataaaa 277981 tcggcggctg gcatgaatac gccaatggca gcatatccgc tttctatgta tggtttgttc 278041 gcagtaattg cagtcgttac cacagtgatt ccatttgtgc taatgcttga gggcataaaa 278101 cgaatcgggg cacagcgagc cgccgccatt tcaatggcag ggcctatcct gacgattttc 278161 tatggagctt tatttctcgg tgaacggctc gggctcattc aagtcattgg atgcggtggc 278221 gtattttttg tcattacggg catggaatac aggaagctga aaacaggaaa aaaagaataa 278281 tttttataaa acacacacgt ttttcaatta caataagtgt aattacgtgt gtgttttttg 278341 attttgtaaa ggttaggtga ggagatgcag cgcatattgc ttgtagaaga cgaccactca 278401 atcagtgaaa tggtggatca ttatttaaca aaagaaggct ttggaattgt gcatgctttc 278461 gacggagaag agggcatccg gctgtttcag cagggttcat acgatttggt cctccttgat 278521 atcatgctcc cgaagctgaa cggcatggat tttctgaaaa tcatccggga aaaaagcaat 278581 ataccggtct taatgatttc ggcaaaagat ggagatgtgg acaaggcatt gggactgggc 278641 tttggggcgg atgattatat cgccaaaccg ttttcgatga ttgagctgac agcccgagta 278701 aaagccgcga tacggcgggc gacgcaatat tcggcagagg agccggctgt gaataaggtg 278761 atccggattc accagcttgc gatagatata gacaatgttt ccgttttgaa aaacggagag 278821 ccgctccagc tgacgtcaac agaatggcag ctgctgtgct tatttgcatc aaatcctaaa 278881 aaagtgttta cgaaagaaca aatctaccgt tccgtttgga atgaagagta ctttgatgat 278941 cagaacatca ttaacgtaca tatgcggcgg ctcagagaaa agattgagga tgacccctcc 279001 tcccctcaat atattaaaac gttatggggc atcggttata aattaggaga gttttagaat 279061 gacagtgcta tgggtggccg ctgtcatcgc tctggcgtgt ctgaatgtga ttcaattcat 279121 aatgaaaaag aagcgggacg ggaatctggc ttacacggct gaccagctta gctacatgct 279181 cagccgggat tcggcaggac aaattttgct tcctacagac gatcatgcgc tcaaagactt 279241 gcttgttaac atcaatctta tcgttgagaa tcgtcagcag atcagcgccc aatttgccaa 279301 aacagagcaa tccatgaagc ggatgctgac caatatgtcg cacgacctga aaacgccgtt 279361 aacggtcatt ctcggttata ttgaagccat tcaaagtgac ccgaacatgc cggacgaaga 279421 gcgggaaaga ttgctgggga agctccgcca gaaaacaaat gaacttattc agatgatcaa 279481 ttcctttttt gatttagcga aattagaatc tgaagataaa gagatcccga tcaccaaagt 279541 acatatgaac gacatatgca aacgaaatat cctgcactat tatgacgctg ttcagtcaaa 279601 aggctttcaa gcagccatcg atatccccga tacgccggtg tatgcgcagg cgaatgaaga 279661 ggctctggac agaatcctgc aaaacctatt gtccaatgcg attcaatatg gcgcggccgg 279721 caagttaatc gggctgacgc tgtcttatga tgagaggaac atcgccatca ccgtatggga 279781 tcgcggaaaa gggattagtg aaaccgatca gcagcgggtg tttgagaggc tgtacacact 279841 ggaagaatcc agaaataaag catttcaagg aagcggcttg ggtttaacca tcacaaaacg 279901 gcttacagaa aaaatgggag gcatcatatc cgtccaaagc aagccgtacg aacggactgc 279961 atttacgatc acattgaaac gcatgacata ttaatcgtaa gaatttctta aggtttgaga 280021 aataaaaatg acagggctcg ccgctacaat agaaaacagg aaaagagagg gaaggagaaa 280081 caaagttgac ttatatcgta caaacaaacg ggctgaccaa aacatatcag ggcaaagagg 280141 tcgtatccaa tgtcagcatg catattaaaa aaggtgaaat ctatggcttt ctcggcccga 280201 acggcgcggg gaaaacaacc attatgaaaa tgctgacgag ccttgtcaaa ccgacaagcg 280261 gtgaaatcat catccttggg aacaagttca cccacacgtc atatgaggtg ctggggaaca 280321 tcggcagcat gattgaatat ccgatttttt atgaaaacct gacagctgaa gaaaatttag 280381 atctgcattg tgaatatatg ggataccaca ataaaaaagc catacaagaa gtgctggata 280441 tggtgaattt aaaacaaatc gacaaaaaac ccgtcaaaac cttttccctc gggatgaagc 280501 agcgccttgg aattgcgcgt gccatcctca cgaagccgga cctgcttatt ctggatgagc 280561 cggtgaatgg tcttgaccct ctcggcatta aaaagatcag gcaattgttt caagtgctga 280621 gcaaagagta cgggatgacg ctgctgatct caagccacct gctgggtgaa atcgaacaaa 280681 tcgcggacac aatcggcgtc attcgggacg gcaggctgct tgaagaggta tcaatggagg 280741 atgtcagggg ccagaacact gaatacatcg agcttgtcac gccgaatcag acaagggcct 280801 gctttgtgct ggagaaagag ctgcaattaa ccaactttaa aatattaaat gagaaaacga 280861 ttcgaattta cgaggctgaa gcctctcagg ctgccatatc caaagcattg attttaaatg 280921 atgtagacat tgaatcaatg aacaaaaagt atacgtcgct ggaggattat tttatcaaat 280981 tgatcaacgg caatagcatc agtgcgtaaa ggaggagaga cacgttgatg aatttgatca 281041 gaatcgaatt aagaaaaatg aaaatgggct ggtatatcag aggtgccctc attgccaacg 281101 tgatcattat gggttttatg tggctgatca gttattccga aaaagccgat ggcggggttt 281161 cgttccaaag tacggatgaa gcattcctca tcatcggcac cttcgtcaga gcggtattta 281221 tcgtatttgg cgctgtgctg atcgtaaaat tggtgatttc ggaatataaa aacaaaacca 281281 ttcttgtgat gttcacgtac ccgatcagcc gtaaaaagct gctcaccgct aagctcatga 281341 tcgcgggcgg actgacgttt atcacgattt tactttcaaa tatactcata gccgccggtt 281401 tcttttggct gaactcgatc tgccatttca taccgggaga gcttacttcc gagatcattt 281461 ctcaacaggc ggtcaaaatg gcggttttcg cttttggcgc cgctggaacc agtttagttc 281521 ccatcttttt tgggatgcgt agacactcgg ttccggcgac catcatttca tctgtagtaa 281581 ttgtgatgct catcagctca acaagtccgg gcttctcgat ttcatctgtt gtgtatatcc 281641 cgttatcgtt agcggcattc ggtttgttct tttcctacat ggcgatcagg aatgcggaca 281701 agcaggatgc gtaaacaaag gcgcccaata tgtataaaag gccgatgctg tcagcaccgg 281761 cctttccatt atgagtctgt tcttgtttca agataatgct tcttgccaat ctctttgctc 281821 atcatataga aatggaagca atattcaccg attgccatga cgatcgcgcc gaataaagcc 281881 gccaatgcaa cttcaccgcc agtcatcccc atagaaagcg gcatgcccat cagccagatc 281941 acgagaaagg ccaaaccaaa atcagccaaa gttgcaatca tattattcca tttcggcaat 282001 acataaagat cgcccagcaa ataagaaata acccctaaca caatcgtcat tagcagcgta 282061 tcaccaaacg tgaaaccaaa gcccagacca agcaccagat acaacacaat aatcgtcata 282121 atacctttaa tagcgagcgc tttcacatgt gtcattacaa ttcctccttt tgtcatttga 282181 tttgttatgt ataattcctc aaatgtaaaa agttaaacct tatttctttt cggaggcggg 282241 tgcaaatctg ctggggagag gtcaatgatg tgaatccagg aattgaggct gcggcgcttc 282301 gacagcggaa acgtgaagct tgtactgcac cggacgctgc tttgatgccc aacagcccat 282361 tatgtttgct gtttttagat gaataaattt aaaaacttct cctgtccctc cgtcatcact 282421 tctgaagtaa tgaaatatga tgaaaagaga tcaaggggag gtgacgtgat ggcggtcgtg 282481 agagcaacga gtgcggatgt cgatttgatg gcaaggctgc tcagagcgga agcggaaggc 282541 gaaggcaagc aggggatgct gcttgtcggc aacgttggaa ttaatcggct gcgggcgaat 282601 tgctcagatt ttaaaggcct ccgcaccatc aggcagatga tttatcagcc acacgcgttt 282661 gaggctgtga ctcatggata tttttatcaa agggcgcgag atagcgagcg tgcccttgca 282721 cgccggtcga ttaatggtga aaggcgctgg cctgcaaaat ttagtttatg gtacttcagg 282781 ccgcaggggg actgtccagc ccagtggtat aaccagccgt ttgtggccag atttaagtca 282841 cactgctttt atcagccgac ggcggagacg tgtgaaaatg tatataacac attttagaga 282901 caggacaccg ttcaaattga acggtgtttt tctttgaaaa gatgcaatgc aaaatattcc 282961 tgtgagataa tcaaagaaaa aagagctgac ggagatgaca gaatggcaac aattgacctg 283021 caaaagaaaa gtgtaaagat cgtactggag aaaaagcagt taacgaaggt gacggctcgt 283081 gttggactgg ttcttgatat tacgggatcg atgagaccgc tctacaaaaa cgggacggtt 283141 caaaatgtgg tggagcggat tttggcagtg gctgatcagt ttgatgataa cggtttgctg 283201 gatgtatggg tgtatgataa tgaattttcc cgattaaagc cagtttcaga aaaggatttt 283261 tcgggctatg tcgatcgtga aattttaaat aatgaccgct tgcataaatt cggcagaaat 283321 gatgagccgc cagtcatgaa ggacgtgctg cgcaaatatg ttacggagga accgagctcg 283381 tatcctgctt tcattgtttt tatcaatgac gggggctgta aaaagtcaat caaaccgata 283441 attgaagctt cttctgataa accggtgttc tggcagtttg tcggcatcgg aaacggaaac 283501 tttgattttc tcaataaact ggatacgtta gaagggcgtg tcattgataa cacgaacttc 283561 ctgcatatcg aagagattga ccgcatttct gatgatgagc tttatgatgc tctgcttgct 283621 gaatttccat tttggctgaa agaagcgaag gaaaaaggga ttgtaagaga acaagagcct 283681 cctgctgaaa agccgaaaaa gaagggcttt ttcagcagat tgttttcgaa ataactgata 283741 aagagcactg agtcattctg cgaaatggct cggtgttttt gtttttttaa gatcatgtga 283801 agaaaaatag gccgaatggg cggcttgcaa acgacaggat atgcagaaaa cgcgtcattc 283861 agccagcttt cggcatgttt cagcagcagg cttgtgaggg aagacctgtt tttaatgttc 283921 agcgcttaca atcagttcac acttcttcac agtcgtttaa caatgatttc ctataatgga 283981 gacgatcaat gaggagagag gggatcttga atggcatacg acagtcgttt tgatgaatgg 284041 gtacagaaac tgaaagagga aagctttcaa aacaatacgt ttgaccgccg caaatttatt 284101 caaggagcgg ggaagattgc aggactttct cttggattaa cgattgccca gtcggttggg 284161 gcctttgaag taaatgctgc gcctaacttc tcaagctatc cgtttacatt aggggtagcg 284221 tcaggtgatc cgctttctga cagtgtcgtg ctttggacac gtctggcacc agatccgctg 284281 aatggcgggg gaatgccgaa gcaagcagtg cctgtcaaat gggaggtcgc aaaggatgag 284341 catttccgca aaatcgtaag aaaaggcact gaaatggcta aaccaagtct tgcccattcc 284401 gttcatgtgg aagcggacgg gcttgagcca aacaaagtgt actattaccg tttcaaaacc 284461 ggccatgaac taagccctgt cggaaaaaca aaaacactgc ctgcccctgg cgccaatgtg 284521 ccgcaaatga cctttgcatt tgcttcctgc cagcaatatg agcacggata ttatacggcc 284581 tacaagcata tggcaaagga aaagcttgat cttgtcttcc atctcggtga ttacatatat 284641 gaatacggcc caaatgaata tgtatcaaaa acaggcaatg tccgcacgca caacagcgcg 284701 gaaatcatta cgctgcaaga ctatcggaac cgtcacgctc aataccgttc tgacgccaat 284761 cttaaagctg cacatgcggc attcccttgg gttgtaactt gggatgacca tgaagttgaa 284821 aacaactatg ccaataaaat acctgaaaaa ggacagtcgg ttgaagcatt cgtgctccgc 284881 cgcgcggcag cataccaggc atactatgaa catatgccgc tccgcatttc ctctttgccg 284941 aatggcccag atatgcagct gtaccggcac tttacgtacg gaaacctggc gtccttcaat 285001 gtgcttgata cccgccagta cagggacgac caagccaata acgacggcaa taagccgcct 285061 tctgatgaat cgcgcaatcc gaatcggact ctgcttggaa aagaacagga gcagtggctc 285121 ttcaacaatt tgggcagctc gacagcccac tggaatgtgc tggcgcagca gattttcttt 285181 gccaagtgga atttcgggac aagcgcaagc ccgatctaca gcatggattc gtgggacggc 285241 tacccggctc agcgcgaacg ggttatcaat ttcattaaaa gcaaaaatct gaataatgtt 285301 gtcgtactga caggtgatgt acacgcaagc tgggcatcga atttgcatgt cgatttcgag 285361 aagacaagtt caaaaatatt cggagccgaa tttgttggaa cctcgatcac ttccggaggg 285421 aacggagcgg ataagcgagc ggatacggac caaattttaa aagaaaatcc gcacatccag 285481 ttctttaacg actatcgcgg atatgtccgc tgtacagtga cgcctcacca gtggaaagcc 285541 gattatcggg tgatgccatt tgtgaccgag ccgggcgcag ccatttccac gcgggcttca 285601 ttcgtttacc agaaagacca aaccgggttg agaaaggtat catccacaac aatccaaggc 285661 ggggtgaagc aatccgatga ggtcgaagag gatcgtttct tttcgcacaa caaagcccac 285721 gaaaaacaaa tgattaagaa gcgtgcaaaa atcacgaatt aaggagtgga aattatgttt 285781 tcaaacattg gaataccggg cttgattctc atcttcgtca tcgccctcat tatttttggc 285841 ccttccaagc tgccggaaat cgggcgtgcc gccggacgga cactgctgga atttaaaagc 285901 gccacaaaat cacttgtgtc tggtgatgaa aaagaagaga aatcagctga gctgacagcg 285961 gtaaagcagg acaaaaacgc gggctgaatg ctgatgaggc agacaccggg tctgcctctt 286021 tttttatgaa agggagggct tttttgaatg gataaaaaag aaacccatct gatcgggcat 286081 ttagaagagc ttcgccgccg gattatcgtc acccttgcgg cattttttct atttctcatc 286141 acggcttttt tgttcgtaca ggacatttat gactggctga tcagggattt ggatggaaag 286201 ctggctgtgc taggaccgag tgaaatcctc tgggtgtata tgatgctttc cggcatttgt 286261 gccattgcgg cttctatccc tgttgccgcg taccagctgt ggcgtttcgt tgcaccggcg 286321 ctgactaaaa cggagcgcaa ggtgacgctc atgtacatac caggtttatt tgcgttgttt 286381 ttggcgggca tctccttcgg atactttgtc ttgtttccga tcgtgctcag ctttttgact 286441 catttatcct ccggccactt tgaaacgatg tttacggctg accgctactt taggtttatg 286501 gtgaatttga gcctgccgtt cggcttcttg tttgagatgc ccttggtggt gatgttttta 286561 acaaggctgg gcatcttaaa tccttacaga ctggccaaag cgagaaagct ttcctatttt 286621 ctgctgattg tcgtgtccat attgattaca ccgcctgatt ttatttctga ttttctcgtg 286681 atgatcccgc ttcttgtcct gtttgaagtg agtgtcaccc tatcggcgtt tgtctacaaa 286741 aagaggatga gggaagaaac agcggcggcc gcttagtgca gcgtaccacc cggtgacttc 286801 acatcctcat catattgtgc ggccgtaaca gcggcgattc tcaatgcccg gacaatcgtg 286861 tccaggctga ggctcggcgc tgttttgtcg attgtttgct gcggaatgta aggaatatga 286921 ataaaaccgc cgcgaatgtg tggggatgtc cggctaatgt gatccattaa cccgtagaac 286981 aaatagttgc atacaaaggt ccccgctgtg taggaaaccg cagctggaat gccgtgttcc 287041 ttcatcttag cagtcattcg tttcacggga agccttgtcc agtaagcggc gggcccatct 287101 ggagaaatct cttcatcaat cggctgatgt ccttcgttat cggggattcg cgcatctgca 287161 aggttgattg ccactcgttc cggtgtaatc tgcatccgtc ctcctgcttg gccgacacaa 287221 attacgatat ctggctgatg tttttgaatg gcttggcgca gagtgtccag agcggatcta 287281 aagacggttg gaatttgttc cgctgtaata atggcttctt ctgtctcgaa gccattaagc 287341 cgtttcgccg cttcccatga tggattgacg gtttctttgt caaaagggtc aaagcctgtg 287401 atcagcactt tttttctcat tctcccatct cctttttctt ttattctatt gtttatttat 287461 gggtttttca tcaaaataat gtaaaggagt gaatcataat ggagcatttg ccggagcagt 287521 atcgccagtt attcccaacc ttgcagacgc atacgatgct tgccagctgt tctcagagcg 287581 cattggcaga gcctgtatca agggcgatcc aggattatta tgatagcctg ctgtataaag 287641 ggacgaactg gaaagaagcg attgaaaaaa cagagtttgc gagaaacgag tttgcaaagc 287701 tgatcggggc tgaaccggat gaagtggcga ttgtgccgtc agtttctgat gcactggttt 287761 ctgtagcatc gtccttaact gcatttggaa agaagcacgt tgtatataca gatatggatt 287821 ttccggcggt gcctcatgtt tggcaggcac actccgatta taccgtatcc gtcattccat 287881 caatagacgg cgtgctgccg cttgaacaat atgaaacgca tatttcggat gaaacagtac 287941 tgacgtgtgt tcctcacgtt cattatcgtg acggctatgt tcaggatata aaagcgattg 288001 ccgagatttc tcagagaaag ggctctttat tgtttgtaga tgcttatcaa tcagccgggc 288061 atattcccat tgatgtgaag gaatggggcg tagatatgct ggcagcaggc acccggaagt 288121 atttgctcgg cataccgggt gtggcgtttc tttatgtgag aaaggagctg gctgacgcac 288181 tgaagccgaa agcatcagct tggttcggaa gagagagcgg atttgatggg gcttatgcaa 288241 aagtcgcgcg ccgttttcaa acgggcaccc cagcttttat cagcgtatac gcagctgcag 288301 cggctttatc gctgctgaat catattgggg tttctcatat cagggatcat gtgaaaacga 288361 tctgtgccga tgcagttcaa tatgccgctg aaaaaggcct gcagctggcg gcggcacaag 288421 gtgggattca gccgggcatg gttgcgatcc gggatgagcg ggcatcggaa acggcggggt 288481 tgctgaagaa gaaaaaagtg atttgcgcgc cgcgggaaaa tgttatccgt ctcgctcccc 288541 atttttataa tacgaaggag gaaatgcggc acgcgattga tgaaatcgcg gcgaaaacga 288601 tccacaagta aacatgaaaa agcccctgaa cactagtcag gggcttttca tattaatgat 288661 ctactttaac gcgtttcata aagaaagcgc caattaaacc gataatggca acaatcattg 288721 caaacacaaa tgcgtgctgt acgcctgctg tcaaagcttg cgggatgact gccggatcgg 288781 cagggttttt aactgtactc atataatcat gctggcctgc agccataatg ctgaccgcaa 288841 ccgctgttcc gatagcgccg gccatttgct gcagcgtgtt cataatggcg gtgccgtctg 288901 gataaaattc acgcggcagt tggtttaaac cgtttgtctg tgcaggcatc atgatcatag 288961 aaatcccgat catcaagcag gtgtgcagga tgataatcag cacagctgtt gaagtggtcg 289021 tgacatttga gaagaaccat agtacaacgg tgacaatcac aaatcccgga atgacaagcc 289081 atttcggccc gtatttatcg aacaagcggc ctgtaacagg ggacataaat ccatttaaaa 289141 taccgcccgg caagagaaca agaccagatg caaatgcagt gaggactaag ccgccttgca 289201 gatacatcgg cagaagcagc atagatgaca gaatgaccat catacaaatg aacaccatga 289261 tcacacccaa aataaacatc gggtatttga acgcacggag gttcatcata ggctgcttca 289321 ttgtcagctg gcggattgaa aataagataa ggccgacaac gccgacaatc agcgacacga 289381 taacagtcgg gctggaccat cccccggagc cttcacccgc gttgctgaat ccgaatacaa 289441 tgccgccgaa gccaatcgtc gacaggatga tagacaatac atcgattttc ggctttgtcg 289501 tttcagatac attttgcata tatgcgatac cgaaaacaag cgccagcaca aggaatggaa 289561 gagagatcca gaaaatccag tgccagttga gatgctccag aaccaatcct gagaaagttg 289621 ggccgatggc gggcgcgaac ataatgacaa gcccgatcgt tcccattgcg gcaccccgtt 289681 tatgaggcgg gaaaatcacc aagattgtgt taaacatcag cggcagtaaa agaccggttc 289741 caagtgcctg aacgatcctt gccgctaata aaaacgagaa gctcggcgca agcgccgcaa 289801 tgaatgtacc taaaattgaa aagataagtg acacggtaaa aagctgtctt gttgtgaacc 289861 actgcaacag cagtcctgaa acaggaacaa ggataccgag tacaagcagg tagcccgtcg 289921 ttaaccattg gacggttgcc gctgtaatgt tcaattcctt cataaggtcg gttaacgcaa 289981 tattcagcgc tgtttcactg aacatgccga taaaaccggc caacagcaag gaaatcataa 290041 tcggcatcac tttgtattgc tgagatgctt tagctgttgt ttccaaaatc atttcccctc 290101 tctatcaact gcatgtagta tgtcgttttt tttatctctt cagcaggtca ggaatgcagc 290161 tggagatatg aaggagcggc gtactgtttt ttgccgtcaa agataaaagg atgccgcctt 290221 caatcatcgc gttaaccaca gtgctggctt cttttgcacg gctctcgctg cagccagtct 290281 gccgcagttt ttcctcatac acagaggccc attctttgta ggcttcatga caggcttcgc 290341 gcaacggttc gcttttcaat gacgtctcag ccgctagcaa gcccacaggc aagccttcaa 290401 tgtcttccgt acatgaaaac tggcaggaga gctccttcaa aaaggcttga atgccttccg 290461 ctggatcggt gcaggcttcc atgcagtccg cgattttctg acggatatac tccttcatct 290521 cattcacggc ttcgatcgca agctgttctt tacccccggg aaagtggtag taaagagagc 290581 ctttaggcgc gccgctttcc tttataatct ggttcagccc cgtgccgtaa tacccttgca 290641 gctgaaaaag ccgggtagct gccgaaagga ttttctcacg ggaatctcca taactcataa 290701 cattcccacc ttactgaatt gcaatcaaaa atatagtgac tggtctatta tcttgattca 290761 atcatcaatt gtcaagaaaa attcattgta tgaaaagaca aaaaaagaag gatatgacaa 290821 caaaaaatac tgagagaaaa gctgactgat cttttgactg aatagataaa atgtacaatg 290881 attaatcatc atatggatgt aaggagagaa atagatgaaa aaacaacgaa tgctcgtact 290941 ttttaccgca ctattgtttg tttttaccgg atgttcacat tctcctgaaa caaaagaatc 291001 cccgaaagaa aaagctcaga cacaaaaagt ctcttcggct tctgcctctg aaaaaaagga 291061 tctgccaaac attagaattt tagcgacagg aggcacgata gctggtgccg atcaatcgaa 291121 aacctcaaca actgaatata aagcaggtgt tgtcggcgtt gaatcactga tcgaggcagt 291181 tccagaaatg aaggacattg caaacgtcag cggcgagcag attgttaacg tcggcagcac 291241 aaatattgat aataaaatat tgctgaagct ggcgaaacgc atcaaccact tgctcgcttc 291301 agatgatgta gacggaatcg tcgtgactca tggaacagat acattggagg aaaccgctta 291361 ttttttgaat cttaccgtga aaagtgataa accggttgtt attgtcggtt cgatgagacc 291421 ttccacagcc atcagcgctg atgggccttc taacctgtac aatgcagtga aagtggcagg 291481 tgcccctgag gcaaaaggga aagggacgct tgttgttctt aacgaccgga ttgcctcagc 291541 ccgatatgtc accaaaacaa acacaactac aacagataca tttaaatcag aagaaatggg 291601 cttcgtcgga acaattgcag atgatatcta ttttaataat gagattaccc gtaagcatac 291661 gaaggacacg gatttctcgg tttctaatct tgatgagctg ccgcaggttg acattatcta 291721 tggataccaa aatgacggaa gctacctgtt tgacgctgct gtaaaagccg gagcaaaggg 291781 gattgtattt gccggttctg ggaacgggtc tttatctgat gcagccgaaa aaggggcgga 291841 cagcgcagtc aaaaaaggcg ttacagtggt gcgctctacc cgcacgggaa atggtgtcgt 291901 cacaccaaac caagactatg cggaaaagga cttgctggca tcgaactctt taaaccccca 291961 aaaagcacgg atgttgctga tgcttgcgct taccaaaaca aatgatcctc aaaaaatcca 292021 agcttatttc aatgagtatt gaagaaaaga aggcgaataa gccttctttt ttttggcttt 292081 ttaggaccaa taatgacctc tgaatcttaa aatttcttta aaaataagcc aaaattaccc 292141 tttacttaat taatttggta acgtaatata attggagaat ttgttacaaa aaaaggagga 292201 tattatgaaa tttgtaaaaa gaaggatcat tgcacttgta acaattttga tgctgtctgt 292261 tacatcgctg tttgcgttgc agccgtcagc aaaagccgct gaacacaatc cagtcgttat 292321 ggttcacggt attggagggg catcattcaa ttttgcggga attaagagct atctcgtatc 292381 tcagggctgg tcgcgggaca agctgtatgc agttgatttt tgggacaaga caggcacaaa 292441 ttataacaat ggaccggtat tatcacgatt tgtgcaaaag gttttagatg aaacgggtgc 292501 gaaaaaagtg gatattgtcg ctcacagcat ggggggcgcg aacacacttt actacataaa 292561 aaatctggac ggcggaaata aagttgcaaa cgtcgtgacg cttggcggcg cgaaccgttt 292621 gacgacaggc aaggcgcttc cgggaacaga tccaaatcaa aagattttat acacatccat 292681 ttacagcagt gccgatatga ttgtcatgaa ttacttatca agattagatg gtgctagaaa 292741 cgttcaaatc catggcgttg gacacatcgg ccttctgtac agcagccaag tcaacagcct 292801 gattaaagaa gggctgaacg gcgggggcca gaatacgaat taatgaaaaa caaaaccttg 292861 aagaatgcta ttcttcaagg ttattctgct ttcagcacaa tggttttcgc agccatatca 292921 tgaacggttt gttttttctt cgtaaatgcg gcagtcaaat agatcaggcg ggagaacaca 292981 tgcacccacg ctatcaggta acggacaatg gcttgcggga aggatatttt tttatatgtt 293041 tcgtccctca cgatttgcag cccgatgatt tttttgccca gtgtgccctt ccaatttgtc 293101 agcggcatca gcaaagggta cacaatcagc atcaatatgg cgacaataat gacaccggcg 293161 gacccatcgc caaacgtaaa tccggctgcc aaaatcactg ctgcggcaat gattacatca 293221 agtaaaagag cgcaggcgcg cagcatgaaa ccagctagtt ccaatagaaa cactccttaa 293281 aatgttaaat aaacacctaa tgattgtaaa aaagaagggc ctaaagtggg aataggtgat 293341 aagccttaaa tcacaaaagt tggtgaaaat gtcataggta aattggcata atcagccagc 293401 ttatcacatt accaaattct tttttagccc gaaaccaagc cctcagaagt tatttttgtt 293461 aaaatagaaa agttacaaca gaattcggag ggtttattgt gggaaaagtg aaacgaaatg 293521 ccccttgccc atgcggcagc ggcaagaaat ataaaaaatg ctgcggaagt aaagttgtcg 293581 acttcccggc ggaactagcg gcaaaagaag cgaaacaaat tcaggaagac ttagtggagt 293641 atgccttcac agtacataga gaaagcattt caggctttat caaccagcat gattttcttt 293701 ctgctatgga cagacagacg aaagacatca gcgtatttaa cttaggaatc tggggaatct 293761 tcttccaccc gcttgctggt gagaagacaa tcttcgaaga gtaccttcag aaaaaaggcg 293821 attcgatcac tcgtccgaaa acgcgtgaga tcgtagaatc atggcagagc atgacgcctg 293881 ctttattgct gctgaaggac ctgaaggaag gcatcattca ctttgaagat gtcattacgg 293941 caaaacaatt cgaagtggaa atggacgcca gcaatcaaga ccttcctcca gtgggaagcc 294001 tgattcttgg atacccaatc cacgaagcgg aaaaagcaga attcttcatg cagttcacga 294061 tcttcccggt gaagagaaca gaagcgctga tcagcaaggt gaagaaatat gcggatgccg 294121 ctgtgaagga cggcaaaacg ccggaggact tcatgaagca ggaattcaac aacgttctgt 294181 tcgcgttgtt agctgagaaa gatgaagagc cacaagcaga gaaagcggaa gtaagcactg 294241 ttgagtgggc aaacgacttg gagaaagaaa ccgctgcggc tattgaagaa ggcatgagcg 294301 gggaagagta tccgactgaa ttgatcccag ctgttattga catctggaaa acattctgcg 294361 agaaaaaatc acctgtcatc agaaagccgg aagcttttgc ggcggcagtt gaatattatg 294421 taaacgcaat ttctcttaac ggcgcgtccg tttcccaggc taaactggcg aaaaaatacg 294481 gcgttagcgc atcaacgatt tccagccgtt acaaagaaat tgaaagcacg ctgcaagatg 294541 aagcagatcg ttttgcacaa gcgttatcct cataatggaa aaaaccttga aaagccaggc 294601 ttttcaaggt ttttttattt ctgaaacgga attttgattt ctaaccggaa gatggggtgg 294661 cggtaggtaa aatccagcct gccaaaagcg cccttcacca gtttttgaat gatatatgtg 294721 cccatgcctt catgagcgcc gtttttcgtt gagcggccaa acgattgata aattgtatcg 294781 agcacttttg ggtccatccc gggagtgctg ttttcacaag tcagtacata aagcccgctg 294841 cgcagtgaag tctccagttt aatctctgct ttttctcggg cctccgccgc gctgtcgagc 294901 gcattttcta atatgttgcc gaccaagctg acctgatcag caggcgaaaa cggaagggaa 294961 gaaagcggtg tatgcatatg cagcgaaaca ctcacattcg aggcgcgggc tttttctaaa 295021 aaatcataaa gcacccctgc aacgtacgcg ttctctcctt tcaaaaaacg gtcatattgg 295081 ctgtattgat ccgcccagtt ttgaatatat gcttgtgtat ctgccttggg ctgagctgat 295141 ttgattgcag tgatatgttt cattgtgtca tgattccggc ttctgacatc aatcagcatt 295201 tgattggcgt gctgttcagc ttgagtcagc ttatcaattt gatcagaaag ccttgcctgc 295261 aaagcagact gtccgatacg gagcccttca caccctgcaa atatcgcgat tacacataat 295321 accggcatga tgtctgtgcc aatcaacacc actcccaccg acatcacttg aatcaccgca 295381 atccacgcac aaagccctga ggaacagtgt ttccacaccc gcttcgtatt ccaaatgtac 295441 aatcctgcag cagctgcgcc taaagcagcg gcgagccaag aggcggctgt gctgtgtgaa 295501 aaagcagcag ctccctgata acatatgaaa ctaaataaaa tcagataaag acattgaaaa 295561 agggtaatca cgtactaaac tcctcaaaaa tagtagtttt gaaaataatc aagctgctgc 295621 ttagtgatca tcgctttttt agacgttccc tcaaaggaaa ctgtgaatga atgcttggta 295681 taagcggaaa aatgctttat gtaatgaatg ttgataataa aggaacgatg cgaacgaaga 295741 aaatcttttt cgggcaggtc gcctttaata tcatttaatg tttgatacgt ttgcacctct 295801 tcggcggttg tcacaatcgt cgtcgaacgt cccgtccgtt ctgcgaaaat aatatccttc 295861 ttttgcagga cgtgcatttc agacttttgc tttatcaata tacgcccatt caaactcgtt 295921 tccgttttct ttttcaagta ccggtcgaag gaagcggcca gacggtcggc atagtacggc 295981 ttcataatat aatcatggac gttcaggtca aaggcgtgaa ccgcataacc gccgtggccg 296041 gtaacaaaaa tcacatccac atcaagtgaa tgggatttga tcaaatcagc aagctcgtag 296101 ccagacatat ggggcatctc gatatcggca agcagcagat caatgtctcc gttctttacc 296161 cgcctgtagg cttccttcgc tgaatcggtg gaaaagacaa tttcgacgtc ctgcattctg 296221 gacacgatcg cttctaactt ctctaaatct actcgataat catctacaag tccgactttt 296281 accattatca ttcccctagt tacatagaat catctttatt ctatcccatt tcacgacata 296341 aaaagaactc ttcgcgacaa ctttatccaa ctaatccagc ttttcgtata tagtcattac 296401 tagaaataaa gataagggag attgtgacat gattacactg accgattgca gccgcaggtt 296461 tcaggataag aaaaaagtag tcaaagcggt gcgagatgta agcttaacaa ttgaaaaagg 296521 agaagtcgtc ggcattctcg gagaaaacgg tgccggcaaa acgacgatgc tgagaatgat 296581 tgcttccttg cttgaaccat cacagggtgt aatcacagta gacggctttg acacggtcaa 296641 gcagccggct gaggtcaaac aaagaatcgg tgtcttattc ggaggagaaa ccgggcttta 296701 cgacaggatg accgctaaag aaaatctcca atacttcggc aggctgtatg ggctgaaccg 296761 ccacgagatc aaagcaagaa tagaagattt atcgaaacgg ttcggcatgc gcgattatat 296821 gaaccggaga gtgggcgggt tttcgaaagg catgaggcag aaagtcgcca ttgccagagc 296881 gctgattcac gatccggaca tcattttatt tgatgagccg acaactgggc ttgatattac 296941 gtcaagcaac atcttccgcg aatttataca gcagctgaaa agagaacaaa aaacgattct 297001 tttctccagc cacattatgg aggaagtgca ggcgctctgt gacagtgtca tcatgattca 297061 cagcggagag gtgatttacc gaggggcgct tgaatcacta tacgagagcg agcgcagtga 297121 ggatttgaat tacatcttta tgtctaagct tgtcaggggg atttcttaaa tgctgagcca 297181 tatttataaa aaagaaatga tcgacgcttt acgcgacaga aaaacgatat tactcacaat 297241 cttagtgccg atgattatga tgcttggact tgtctttttt tatgaaagca tgctgtccga 297301 caaaggggag cagtacacgc tggctgtcgg ccattcgctt ccgcccgcac tggaaagcaa 297361 gcttaatgag attgacgaaa tcagcgtaaa aacatttgca aagcctgaag aggcagttga 297421 tgaaggaaaa gcagatgcct atctgaacgt cccgaaagag ttcgactcat atgtcaacag 297481 catgacacct tttaaggttg atgtttacgg caattcaatc gatcaagggt cgtcaaatgc 297541 catgcagctt gtgcagtctg ccttagatca gtacaaaaat gaaattgtgc agcaacgttt 297601 aacaaataag catattgatc aatcggtgat ccagccgttt acaattcagc aaaaggaagc 297661 ggatgaggag aaagggactt ccgctattat gctttccgcc attctgccca tgctgattct 297721 gacttccatt gtttccggcg caatgccgat cgctcttgat atcatggccg gtgaaaagga 297781 ccgaaagtca atcgaggcgc tgctattaac gccagtcagc agaaacaaag tgctggtcgg 297841 caagtggctt gcggtttcca cttttggcgt ggcttcaggt gtatttgctt tggtgttttt 297901 gattttgtcc accgtgttat ttaccgaaaa tttaaaaacg gccttccagc tgggagatca 297961 tatgtggagt gtaatcggcg cttcagcctt aatcattgtg ctctctgcat tgctgatatc 298021 tgcgatggag cttttcatca gcatcatgtc cagctcggta aaagaagcgc aaagttatat 298081 gtctctcgtc gtctttctgc ctgtgttccc gatgtttttc atcttcagca aggcaccgaa 298141 ccaatttgac ttatcatact ttctcatccc gtttctgaac ctgcatgcgt tatttaaaca 298201 gcttttattc gggatggttg acccggctac cattttgtct acgtcaggaa ccatcgccgt 298261 gctcatcgcc atcttctttt tactagccag agcctgcttc ctgaaagaca aatgggttct 298321 tccaaaataa acttgcgaaa ggagaaatac actttctcct ttttgtatat cctgaaaaaa 298381 gaaggaaaat agaaaaagga tatctaatac aaaaagtgac cctgcactat ttttcatcaa 298441 aattggtttc aaaggagaag gaacaatgga tcaaacacgt acactcggca aaacgaagct 298501 gaaggtgaag cggatcggat tcggcgcgaa tgcggtcggc gggcataatc tatttccaaa 298561 tctaaatgat gaaacaggga aggatttagt gcgcacggca ttggatggcg gcgtcaattt 298621 tatcgatacc gcctttatat atggattggg gcgatctgaa gaattaatcg gcgaagtcgt 298681 acaggaacgc ggcgtgcgga atgagctcat catcgccacc aaaggagctc ataaagaagt 298741 ggacggcagc attgaattag acaatagccg ggagtttctt cgcagcgagg tggagaagag 298801 cctgaagcgg ctgaaaacag attacattga tttgtattat gttcactttc cggatggaaa 298861 aacacctctc gctgaagtgg cgggcacttt gaaagagctg aaggatgagg ggaaaatcaa 298921 agcgatcggc gcttcgaacc tcgattatca gcaattgcag gattttaatg ctgacggcta 298981 tttggaggtc ttccaggccg aatattctct catacagcgt gatgccgaga aagagcttct 299041 tccatactgt gaaaaacaag gcatctcctt tattccttac tttccgcttg cgtccggact 299101 gctgacagga aaattcacgc aagacacagt ctttgatgat ttcagaaagg ataaacctca 299161 atttcagggt gaaacgttta tccacaatct caaaaaagta gataagctga aagcagtagc 299221 ggaggaaaaa caagcggata cggcacatgt cgccttggcg tggctgttaa cgagaccggc 299281 gattgatgcc attattccag gagctaaacg accggagcaa ttacaggata acctgaaaac 299341 cttgaacatt gaactgaccg aagatgaagt gaatttcatc agcgacattt tcaaataaaa 299401 aaggaaatag ccgtcatggc tatttccttt tggtgtttta ttctttgatg aatgcttcga 299461 ctaattctgc tgctctgtaa tcatccatat caagctgcca ttggtcgatg tcatttttct 299521 tcattttcac ttcaactgtt ttttcagatg aagcaggtcc aagctttttg aattcctcag 299581 gatagacttg aagcgcgtat ttcactgcct cttcatagct ggcactagag tttttactgt 299641 agtagtcttt cactttgtct tcgatgcggt ctgaaagaga agatgcatct acaggtttaa 299701 ctgtggcttc aacaattgct tcgtctttag agattgaagt cgtttttgct tgaatggaag 299761 agtttttgct taatccctct ttaatgccgt tcacgatatt atcaagcgct ttgctgtccg 299821 catatgtgct ggaaaggccg gaagctgaga gataaccgtc tttggctgat tcattaaaat 299881 catttacaat ttcatttttg ttagcgccgg tgattttttc gaaatcggcg ttatctttgc 299941 cgaaaagaag gacatcaaca taagctgata acgcttttgc agaatcttgg agcttatctg 300001 ccgtcgccag gatttttttg tcttttccgt caattttaaa agtaactgat tttggctttt 300061 tatcaccgta agattccggc gtatagttaa gctcgtattg cttgccttta tctacaacga 300121 agaaaagatt tccttcaacg gatttgtcag cgttaatcgt gctgccctga agcttttcgc 300181 tatagtcttc agggtctgtg tcagacattt tggtatcacc ttgatacaat gtgaaatcca 300241 tactgtctac attcagcggg tcttttcctg tgtttttcac cgcgacattg acttttaaca 300301 caagctggtc atctgaagtg gacttatcat atttagacgg aagtgtgtaa gagacatcct 300361 tgattttgac ttgagctata tctgagcttt tttctgtttc tgattctttc ttctccgcgc 300421 ttgttttgct gccggaacaa gcagctgtaa acatcatcag cagaagaatt aggaaaacag 300481 cgtacgtttt tttctgaaac attcattttt cctcctcaaa tggtttagga aaggggagtc 300541 ttttgtcttt gagaaatgga tctttttgaa tggattagca tcatataacc aaaaaaatca 300601 gttcttttct cacggttttc accggatttt ctggaaactc cgccctcctt tgtcatgaat 300661 ggacctataa aaagttacaa cggaattaat tttaagatta ttagctttta tattgaatag 300721 gttcatcatc ctatttttgg tgaaaaatgt tctggtaaaa ctggtaaact cagaaaactg 300781 tgtattttag actattactt tttgattagt tggagggaac ttaagaagga tgaaaggggc 300841 cgcctttgtg aagaaagagg gactgaaaca aaaagcactg gaaatcggcc gggtgccgac 300901 acacttaaaa ctggaaattg aagattatgg cggtgatgat aaaagagctc atttttgttg 300961 ggcagatcct caggatgaga ataccggcat tatcgtggag cttggaccgg acggagagct 301021 ggaatccctt tcccgtgata ttgagcctga aagcggagaa aggctgtctg aggagaaact 301081 agaggatatc atgcgccaat ttgtcgagac tcatcatccg ggggcactct ctgcctttgt 301141 tcgtgaagaa aatgaccgtg catacggcga taaagtgaga ttttcatatg ttcaaatgga 301201 ggctgggctt cctctcccca tgagcggatt tatggctgat gtttccttat caggtgagat 301261 tgtttacttc cgttattacg gcgaagcggg cagcatcatc aagccaaagc gggtcgcgga 301321 tgttgaagag gcacttgcct ttatcaagaa ggacgtggag ttcgaccttt tgtttgaggt 301381 tctccatcgt tctgtttaca aaaacggaga tgatcagccg catttggtgt acgagcctga 301441 aggtagggcg attaccgtac ctgcggattt ggttcaagaa gaacaagcag ttgatgatga 301501 cgatgattac agggagccgg agagctttcc tctcccttta ttcgagggca tccgcgaaaa 301561 ggccgatcct gacagcatga ttggtattga aaatgggttt gtcaaagagc gggaagcgga 301621 tttgggagat gggagaattg gaatcgtttg gcggaatccg gatgaccctg tgtatcagcc 301681 ggcggataaa agcatggaca gctggtttaa gggacggact catcaagtgc tgaaaaccat 301741 ctataacaaa gaaaccggaa aactcgaagg cgtcatgtca tttatggaga aaaaagggcc 301801 gctgacagta accttggcag agtgtgaaaa aatcgcgctt cgctttctat ttgctttatt 301861 tccgaatgcc gatcaatatt ttaggatcag atacgacgaa aaagatgaag aagaaaacgc 301921 agtcgctggt tttacgtttg aagcgcattg tcacggagtt ccgctccgat ttgggcagat 301981 cagaatttgt gtcagccgcc agacagggta tatcaccgtt tatatgggac cggatattga 302041 cccaaataag ctggcaacca ttgatcctgt gccggctatt tcagttgaac aagccaagtc 302101 tatcttttgg cagcatttta aagttgagct tggctgggaa agagagtacg gggatgatga 302161 agaacacagc taccggctcg tctataagcc ggtgtatccg cattttatcg atgcacatac 302221 aggggagcct gtcttcagca tatggtgaaa cagccaaaag tcacgcaatt gcctcagata 302281 tagaagagag tatgtgatga aagtaacaga aagaatctca aaaaacaatg acaataatag 302341 aaaaggacct ttcttcactt taaatgaaga aaggtctttt tatataataa acaggattct 302401 ctttgtcgta gactctttga aagggatgac ttcattggtt aataaacagc tgaaaaagaa 302461 ggcgcaggag atcggaaatg taccgacgca ttatgagctt gagatagaag attacgacca 302521 aaagcaaaag aagtacgggc aggcatattt tatctggaag gaccctaaag atccggaaaa 302581 gcacattaca gttgaactta gaaatgacgg cgccttgctc accttttcaa caactgtcca 302641 ctccgagaca gacaaaaaac ttccagatgc cgagctgaag ctgacggctc ttcagtttgc 302701 cgctgccaat catcccggca catttatgaa ttttcatttt caaggcaagg aagaaagggg 302761 gcagcacatc cggtttgtct ataccaaaat ggagctgggg cttccgattc ccaattcagg 302821 ctttttaatt gatatgacac gaagcggtca gattgtccac tttctatatt acggggaagg 302881 gcataaagcc gaagttccga cggaatttgt agcaaaagag aaggttgtat cccattactt 302941 aaacacaatg tcttttgagc tgatgtacga tgtcattgat ggcgaacagg aaccaaggct 303001 tgtatatgaa ccgattctac cgggatacag ctatcccgca gatgtagacg aaattgtgcc 303061 cgaccagcat atcgcagatg aaagaataga aaacacggcg ccactgccgc cgcttcagaa 303121 caaggaagaa gttgatatat ttgccttgct gggttttacc tctgatatgc agaaagtcag 303181 tgaaagagac tttggagaac aaattggaag cacgtggcgc aggggcgctg cgccggagcg 303241 taaggattta agcataggaa gctattttga aacgagaaat aaaaatacaa tcaaaatgaa 303301 gacggataaa agaaccggaa aattaaaagc agcgctttct tttatggact ggcggaacaa 303361 cctccaatgc tccacggaag aatgccaaga gatagcgctt caatttttgt atgccctcta 303421 tccgagagcg gctgagtttt tcagggtgaa tcccgtccga attgatgaaa gagggagagt 303481 ccgcaaccat ttttctgtct ggtataaagg agtgccgctg cggttcggcg ctgcccgcat 303541 cattgtcaat ccggaaactg ggttgattga cgcttttatg gcgcctgata ttgaacctga 303601 acaattggaa gcgataaatc acaggccgga tgtttccgct gaagaagcga aagaagcatt 303661 tttagccgct tttgatgtga aactggaatg gcagcctgat tttacagcag gcagtgacca 303721 gcactgcaaa cttgtctata agccggttta cccttcctat attgatgcgc acataaggaa 303781 aaagaaaagg ctgtgagggg tgtctagtta ggaatcatct ccaagtgggg gtagtccttg 303841 aatcgtttcc aatccccgcc ccattcgaaa ccgagtgtct tagcgatctc gacaacctcc 303901 agccaatctg attttccgtt ttgattgccg tcatattcca tatcccatat gatgctgcca 303961 tccttttttt gaagggcgaa atcaatcgct aaaccatagt tatgatacga ttcccctcct 304021 cttgcatagg tgacaatatt cccttttttt gtacgtccct gtttatataa ttcatcttgt 304081 tccttaaagg acctgaatcc ttcagtaatg acgacgtcaa tgcctttatt cgctgcagcg 304141 gctttgagtg catcggcatt ctgcttcaca atcggatgaa gatccgaggg gacaggcatg 304201 tcctgcaagg cgttttgaga atgccattca tgccgaatat aactaaaaca aagatctaga 304261 agaaatagaa tacataagat aacaaatgtt tttgcgggta agttcatatc ggtctcactt 304321 tctcaagatg tgctgaatgt taacgctttt aagtgattga ctctctctaa aagcgaacag 304381 ctatgataaa atataacata aatagtagca ggaggaagga ggcagaccga tgagagcaaa 304441 gattccatca gaagaagtag cagtaaagct gaatgaatgg tacaagctca ttcgcgcatt 304501 tgaagcagat caagcagaag cgttaaagca ggagattgaa tatgatttag aagatatgga 304561 agagaatcag gacttgcttt tatatttttc tttgatggaa ttccggcatc gaatcatgct 304621 tgataagctg atgccggtga aagacagcga taccaagcct ccgttctctg atatgctgaa 304681 cgaaattgaa agcaatcagc aaaaactcac gggcttactg gaatactact tttattattt 304741 cagaggaatg tacgaattca agcagaaaaa tttcatatta gcgattgacc attataaaca 304801 tgccgaggaa aagctcgagt atgtcgagga tgagatcgaa aaagctgagt ttctttttaa 304861 agtcgcagaa gtgtattatc acatcaaaca aacgtatttt tccatgaatt atgcgagcca 304921 ggcgcttgat atctatacga aatatgaact gtacggtcgc cgccgggttc agtgtgaatt 304981 tatcatcgcc ggaaatttga ccgatgtgta tcatcatgaa aaagcactga cccacttgtg 305041 cagcgcttta gaacatgcca ggcagcttga agaagcgtac atgatcgctg ctgcctatta 305101 taatgtcgga cactgtaagt acagtctggg tgattacaaa gaagcggagg gctatttcaa 305161 aacagccgcc gccatttttg aggagcacaa ctttcagcaa gctgttcaag ctgtattttc 305221 actgacccat atctactgta aagagggaaa atacgacaag gcagtagagg cttatgaccg 305281 cgggataaag agcgcggctg aatgggagga tgacatgtac ttgacgaaat tccgcctcat 305341 tcatgagctg tatcttggaa gcggcgacct gaacgtgctt acagaatgct ttgacctgct 305401 ggaatccagg cagcttcttg ctgacgccga agatctgctg catgatacag cggaacgttt 305461 caatcagttg gaacattacg agtccgccgc tttcttttac cgcaggctga tgaatattaa 305521 aaagaagctt gccgagcagc gttttcaata ggaaatggca gagaactaca ggttctctgc 305581 tttttttgtg ctgttttcaa ctcggaaaaa cagggtattt tccactgcat agtgagaaac 305641 agaggaggat atcaagtatg tacaaagatt taaccggaaa aacagcgatt gtgacagggt 305701 cttcaaaagg aatcgggaaa gccattgcgg aacggttcgg aaaggagaaa atgaatgttg 305761 ttgtaaatta ccacagcgac ccgtctggag cagatgaaac tctggaaatc attaagcaga 305821 acggagggaa agccgtctca gttgaggcgg acgtgtcaaa agaagagggg attcaggcgc 305881 tcttggacac agctttagag catttcggca cgctcgatgt gatggtaaac aactccggtt 305941 ttaacggcgt tgaggcgatg ccgcatgaga tgagtcttga agattggcag agagtgattg 306001 atgtcaatgt taccggaacc tttctgggag cgaaagcagc acttaaccac atgatgaaaa 306061 acaatatcaa gggcaatgtg ctgaatatct caagtgttca tcagcagatt ccgcgccctg 306121 taaacgttca gtattccaca tccaaaggcg gcatcaagat gatgacggaa acgctggcgc 306181 tcaattatgc ggataaggga atccgcgtca atgcgatagc gcccggcacc attgccacag 306241 aatcaaatgt tgatacgaaa aaggaagaga gcaggcaaaa acaattgaaa aaaatcccga 306301 tgaaagcctt cggaaagcct gaagaagtgg cggcagcagc agcttggctc gtatctgagg 306361 aagcaagcta tgtgaccggc gcaacacttt tcgtcgacgg cggaatgaca ctttatccat 306421 ctcagcttga atagaagaca aaacaggggg attgcgggat gaaaacagac tggtggaagg 306481 atgcagtggt gtaccaaatt tacccgagaa gctttcagga cagcaatgga gacggaattg 306541 gggacttgcg ggggattatt tcccgtcttg actacataaa ggagctcggg gcagatgtga 306601 tttggatttg cccgatctat ccttctccga atgttgatta cggctatgat gtgacaaacc 306661 ataaggcgat tatggattct tacggaacaa tggacgattt tcacgagctg ctggaccagg 306721 tgcatcagcg gggattaaag ctggtgatgg actttgtgtt aaatcacacc tcggtcgagc 306781 atccgtggtt taaagaagcg gagctggaca aaaacagcaa ataccgtagc tattattatt 306841 ggcgtcccgg cacaaagaac ggcccgccga cggactggct ctcaaactat ggatgcccgg 306901 tctggcaata cgaagagcac accggagaat actatctcca tatgaatgcc gtcaaacaag 306961 ctgatttaaa ctgggaaaat cccgaagttc gccaggcggt gtatgacatg atgaaatttt 307021 ggctcgataa aggggtcgac ggtttgcgaa ttgatcagct ccatctcatt tctaagaaag 307081 aatatcttcc ttcgtatgag gactatatca atcagcaggc agagccgaag ccctttcagc 307141 caaatggcga acgaatccat gactatttaa aagaaatcac agatgaagtg ttttctcatt 307201 atgatgtcat gtctgtcgga gaggtcggca gtgtcacacc ggaagaaggc ctgaaatata 307261 cgggaacaga taagcatgag ctgaatatga tttttcactt tcagcatatg gagcttgatc 307321 agcagcccgg aaaagaacat tgggatttga agccccttga gctttctgat ttaaaatcgg 307381 ttttgacaaa atggcaaaag aagcttgaac atcaaggctg gaatacattg ttttggtgca 307441 accacgacca gccccggatt gtgtccagat tcggagacga tggggaatac cgcaaagcat 307501 cagcgaaaat gctggcagcc gtaatttatt ttatgaaggg cacgccgtat atttatcagg 307561 gagaagaaat cgggatgaca aacgcgccgt tcacccggat tgaagactac aaagatatcc 307621 aaacgatcaa tatgtatcat aaacgggtgt ttgaaaaagg ctatgatcca aatgatgtga 307681 tgagatcgat cttagccaaa agccgggatc acgcccggac cccgatgcag tggaacagcg 307741 gcaaaaatgc cggatttact gacggcacgc cttggctgaa ggtcaatccg aacttcaccg 307801 caatcaatgt ggaggaagcg cagggagatc ctgattctgt cttaaactat tacaaaaagc 307861 tgatcagcct gagaaagcag tacgctgacc tcatgaaagg gagctttgat cttttgcttc 307921 cggacgatcc gcagttgttt gtatacatga gagaaaacag taaacaacag cttttgtcgg 307981 tcaataattt ttcaaaagag caggctgttt ttcagtggcc taagaactgc ggcaaagctc 308041 aggcctcact gcttctcagc aattataaca acgatgatct tgatgacgaa atggtgttcc 308101 ggccttatga gagcagggtc tatcttctgg acaaaacaaa ctaatgattg aagtagcccg 308161 gcatttttag ccgggttttt ttagtacata tattcgctct gcaggcggga agaataaatg 308221 aaaatgaaat ttattcttgc aaaacgtaat gacttcggtt tattatgata taggattaca 308281 aaatcgttat cattttgatt taaagttact gaaaaagagg ggatatacga tatgtttaaa 308341 aaatggagcg gtttgtttgt gattgcagcg tgctttttat tagttgcagc atgcggcaac 308401 tcatcaacaa aagggtcggc ggattcaaag ggtgataaac tgcacgttgt cacaacgttc 308461 tacccgatgt atgaattcac aaaacaaatt gtaaaagaca aaggcgatgt ggatctgtta 308521 atcccatctt ccgttgaacc gcatgattgg gaaccgacgc cgaaagacat tgccaacatt 308581 caggatgctg atttgttcgt ttataatagt gaatacatgg agacatgggt tccgtcagct 308641 gaaaaaagca tgggccaagg ccatgccgtt ttcgttaatg caagcaaagg cattgattta 308701 atggaaggct ctgaagaaga acacgaagag catgatcatg gggagcatga gcacagtcat 308761 gcaatggacc ctcacgtatg gcttagccct gttctggcac agaaggaagt taaaaatatt 308821 acggctcaaa tcgtgaagca ggacccggat aacaaagaat actatgagaa aaatagtaaa 308881 gaatatattg caaaactgca ggatcttgat aaactatatc gtacaaccgc aaaaaaagcg 308941 gagaaaaaag aatttatcac gcagcataca gcttttggct atctggcaaa agaatacggc 309001 ttgaagcagg ttccgattgc agggctttca cctgaccaag aaccgagcgc agccagcttg 309061 gcaaagctga aaacatatgc caaagaacat aatgtaaaag ttatttactt tgaagaaatt 309121 gcatcctcaa aggtcgcaga tacgctcgcc agtgaaatcg gcgcgaagac agaagtgctg 309181 aatacactgg aaggcttgag caaagaagaa caggataaag gtttagggta tatcgacatt 309241 atgaaacaaa acctcgatgc cctgaaagat tcactattgg ttaaatcata agatagtgtg 309301 cgccggaggg gtgcacacta tttctttgtg agaaaggaag attaacatga atctcgtctc 309361 attgaaagat atcgttttcg gctattccca tacgcctgtt ttagataaag tatcacttga 309421 tattgaaagc ggtgagttcg tcggcatcac tggaccaaac ggcgcctcta aatcgacgct 309481 cataaaggta atgctcggca tgctgaaacc gtgggaaggc acagtgacga tcagtaaaag 309541 gaatacagaa gggaaacgcc tgaccatagg gtacgtcccg cagcaaattt cttcatttaa 309601 tgccggattt ccgagcacgg tgctggagct tgttcagtca ggccgctata caaaagggaa 309661 atggtttaaa cgtttaaatg aagaagatca tcttgaagta gaaaaagcat tgaaaatggt 309721 ggaaatgtgg gacctccgcc atcgtaaaat cggtgattta tcaggcggac agaaacagaa 309781 aatctgtatc gccagaatgc tcgccagcaa cccggatctg ctgatgctgg acgaaccgac 309841 gacagctgtt gattacgaca gcagaaaagg attttacgaa tttatgcatc atctcgtgaa 309901 aaatcacaac cgcacagttg tgatggttac tcacgaacaa aacgaagtac agcaattttt 309961 agataaagtg attcgattag agagaggaga aaaaggcgga tggaaatgtt tgacttggaa 310021 ttcatgcgac gagcttttct agcaggcggc atgatcgccg tcatggctcc gatactagga 310081 gtgtatctcg ttctcagaag acaggcctta atggctgaca cactttcaca tatctcattg 310141 tcaggtgttg ccatcggctt ttttctcagc accaatataa ccgcagcaag catagtcgtc 310201 gtgaccatcg gcgcgatcgg aattgaatac atgcggcggg cgtatcggac ttattcagaa 310261 gtgtccattg ccatcttaat ggcagctggt ttgtccttcg cgatgttttt aatcagcctt 310321 tccaaaggca cagccaatat gagcatcgat caatacctat ttggatcgct tgtgacagta 310381 aaccagcagc aggtctatat tatcagtatt atcacactgc tgatcctgct ttattttatt 310441 gtactgagaa ggccgctcta cctgctgacg tttgatgaag ctacagccaa aacatcggga 310501 atcaatacaa acgttctctc gttgtcattc agtattgtca caggccttgc gatttcagtc 310561 attattccga tcatcggggt ccttcttgta tcggccctgc tcgtattgcc ggcagccttc 310621 gccatcagaa ttgcaaaagg ctttaacatg gttttcatta cagccatact catttcatta 310681 ttcagcgtat ttacgggact gacatcatcc tatcagctcg ggacgccgcc aggtccgtct 310741 attaccctgc tattgatcgt tttgctatta atcggatttg cagttcaggg agtttggacg 310801 tttatcaaaa aagaagctca gcgcaaaaaa agaagccgat aacatgaaaa gcagttttcc 310861 ctagggaaaa ctgctttttt tatagaaaca attcggcaag gcgctcataa gattcttttt 310921 tcgcctcaaa atcaaacaca ttgcacagaa ccatgatttc atttgtttcg tagcagcctg 310981 tgaggtctaa cagctgttgt ttgacagtgg tgggagaacc gatcaccatc cgctttctgt 311041 tttcttctat gagtttttta tcggacgctg tatagggatg agctttcgct tcctcgatgc 311101 ttggcacgcg gctgtccaag ccttttccga cgcgaagaag ccacagatcc tggcttaatg 311161 cgagttcttc tgcctcttca tctgtttttg cgcaaatgac aaaaatcgta aacagtgcgg 311221 atggattcga aaaatgggct gagggccgaa agctttcccg gtagatgcgg aatgcatttt 311281 ctcctcgctc gggattaatg aaatgcccaa atacatatcc aatcccctgg tgcgccgcgc 311341 gtcttgcgct gttttcacca agaccgagca cccatagctc gggtgccgta ccaataaggg 311401 gcgccgcttt gattccggca tacggatggt cgggaggaag ggaatctgtt agaaaataag 311461 agacatcctg cagctgtctg ttaaattcgg ttaagctttt tttcaccccg tccgttaatg 311521 caagtctggt ttttgtcgtg ccgccggggg agcgaccgac gccgaggtca atccggtttg 311581 gatacagggc ctcaagctgg cgaaaggttt cagccacttt aaatgggctg tattggggca 311641 gaagcacgcc gcctgatccg acacgaatgg tgtttgtctg tgctgcgatg cgggcgatca 311701 tgatttcagg cgctgtgctt gccagtcctt tcgtgctgtg atgctcggca aaccaataac 311761 gcttatagcc ccactgttcg cttaattggg caagctcaac cgaatgctgg agagttgtca 311821 cagggctttc tcctttagaa acaggtgcct gatcaagtat gcttaaatga atcaaaaggc 311881 cgcttccttt ctgtctgttt ttagatggtg acaccagaat aggcaaaatg acttgcccgc 311941 gtcaaatggt ttgtttaaga agcgcacttt atagcatttg caaatcatat atcaaatatg 312001 gaagtttttt ttcgaggttt ttcgtcaatt attcttaact tttacgaaac tttgatataa 312061 taacaaacgt atatattagt aatttacggc ttattttcct tgtgagcgta aaaataaatg 312121 tgactatctt cacattttga tgagtaggag tgaatcgtgt ggcaatttct ttagaaaaag 312181 gtcaacgaat tgatttaaca aaaggaaaag ccggtctgtc aaaattgatg gtcggtctcg 312241 gctgggaccc agtgtcctca ggcggaggat tcttcagcaa actgcttggc ggaggcggtc 312301 cgaatatcga ctgtgacgct tcagtgctga tgctggaaaa cggaaaattc accgataaga 312361 aaaacctgat ttatttcggc aacctgaaaa gccgctgcgg cggtgtacag catacaggcg 312421 acaacctgac gggtgacggt gcgggcgatg acgagcaaat tatgatagat ttagataaag 312481 tgcctggaaa catcgataag cttgtatttg tagtgaacat ttacgattgt gtcagaagaa 312541 aacaagattt cggcatgatt caaaatgcgt ttatccgcgt agttgatcaa tctaatcacg 312601 aggaaatgct caagtacaat ttgagagaca attacgccgg cagaacaagc ctgattacag 312661 cagaaatcta ccgcagcggc agtgagtgga agtttgcggc ggtcggtgaa ggcacaaacg 312721 atacgagatt agaagatatt atcagtcgat acgtataaaa gaaaaggagt ggatgaaaca 312781 tgacaatttc attggcaaaa ggacaaaaag tagatttaac aaaaacaaat ccgggtcttt 312841 caaaggttgt tgtcggttta ggctgggata cgaacaagta tgacggcggg cacgactttg 312901 atcttgactc aagtgtgttt ctgttagacg ccgcgggcaa atgcgcgtca ccaaacgact 312961 ttattttcta caaccagctt gaaggcggca acggttcagt cgttcattca ggcgacaacc 313021 tgactggtgc tggcgaaggc gacgatgaga atgtaaaagt aaatctcagc gctgtaccgg 313081 caaacattga taaaatctca tttgttatta ccattcacga tgcagaagcg cgcagccaaa 313141 actttggaca agtatcaaac gcgtttgtcc gcatcgtaaa tgaagaaaca aatgaagagc 313201 tcatccgtta cgatcttgca gaagatttct ctattgaaac ggcaatcatt gcaggggagc 313261 tttacagaca taacggcgag tggaaattct cagcaatcgg ctcaggctac caaggcggcc 313321 ttgcccgcat tgcaacagac tacggtttgc aagtcggtta agacaaatac gaagagcaga 313381 aaggagagag gcagtatggc cattcaatta tcaaaaggac agcgcattga tttaacaaaa 313441 acaaatccgg gactgactaa agcggtgatc ggcttaggct gggatacaaa caagtactcc 313501 ggcggacacg attttgacct ggatgcttcg gcctttttag ttgatgcgca tgataactgc 313561 gtaaatgatc tcgatttcgt cttctataat aaccttgaac atccgagcgg cggtgtcatc 313621 catacgggtg acaaccgcac gggtgagggc gacggagatg atgagcagat tatcgttgat 313681 ttctcaaaaa tccctgctca cattgagaaa atcggcatca cagtgaccat tcacgacgct 313741 gaagcacgca gccaaaactt tggacaagtt tccaatgcat ttgtccgcgt tgtggatgaa 313801 gaaacgcaga atgagcttct tcgcttcgat ttgggagaag acttctccat tgaaacagct 313861 gttgtcgttt gtgagcttta cagacacggc ggcgagtgga aattcaatgc aatcggcagc 313921 ggattttccg gcgggctggc tgcattgtgc cggaattacg gtttgcaagt gtaagcgagt 313981 gacaaataga gaagtcaccg tttcaaatta taggaggaaa aaacttggac tttttacatc 314041 atattttgtc tacgtatgct tcatttttcg attggaaaat gtggggggaa gttctgactg 314101 atcctgtttc ctggggtttg atcggttccc ttgttgttct ggaaggcctt ttatcggccg 314161 ataacgcgct tgttcttgcg gtcatggtta aacacctgcc ggaaaaacag cggaaaaaag 314221 cgttaacgta tggtttgttt ggagcttata ttttcaggtt tattttcatc gggctcggta 314281 tgcttctcat taaattctgg tggatcaagg tgcttggcgc gctttacctg gcttggctcg 314341 tcattaagca cttctggata ggcgaaaaag aagaggaagc ggacggcatg aagaaaaact 314401 cttggatggt ccgcacgttc gggatcttct gggcgactgt catttcagta gaattaatgg 314461 atcttgcctt ctctgtggac agcatcctgg ccgcgtttgc agtatctgaa aaagtatggg 314521 tgcttctgat tggcggtatg cttggtattt taatgatgcg tacagtggca aaagtgttcc 314581 ttgtgctgat tgataaaatt cctgagctgg aaaacacagc attcgtctta atcggcatta 314641 tcgcgctgaa aatggcgggg agcgctttcc attacgaaat gccgcactct gtattcttca 314701 ttatcattat cgctgcattt gcggtaacat tgatcattca ctacatcaat aaacaaaagc 314761 aggtgcgcga acaaacagcc gcttcaaaag aagaataaaa caaaacaagg agggaggttc 314821 aatgtccttc cttttttgtt accgaaatat cgtttcaatg acaaaccgga aaggaggata 314881 tgatgagaca agaagaacta accattcata aagcacttcc ggctgatggc gattggaaaa 314941 gcctgctgtt tcagccattg ccggagcggg atcactatga aactgcacaa ggcctttctt 315001 tttctcgtct tgccggtcag atattgggca cgcctattga tgagacggac tactataacg 315061 agctgtatga gctgtctgta aacgaccgca taacgatttt gagtgaaacg cttgataaaa 315121 caatcgaacc ggaaacattt caaaagcttc agcatattca ttccatcaat cagaaagaaa 315181 aagggctgtc agtcagccgc tttgttgcct ttctggacgg ggaaaagctg attgcgaagc 315241 actcaaatcc cttgatgcac cgccatttaa gaaaagcgtt gatgacgctt ttacatacct 315301 ttgcggacag tcatgaaaag gggctgaatc atcctgattt tcgcagagtg ctgcttgatg 315361 tctcgaagtt ttccttaaac catctgaacc cttggctgga aaaaaccgat atagagcggg 315421 agatgccgaa ggttgtttgg tatggagatg cgacgaaaag ccagctctat ttcttatatt 315481 atctgatgct ggtcggctgt gatgtactgc tgttccatcc ggcgggaacg gatcagctgg 315541 cgcttgtcga cccgaagcag gagctcggtt ttacggaaaa gctcccggat gtttcggagc 315601 ttcagccgtt tccgaaagaa aaaccagacc ggaaatcaac agtggcttac cgctcaacaa 315661 aggaaattga acatgtgctg aatcacgagg aatccatgct atataagccg tggcagttca 315721 gagatcacac accggtgtcc gttacgctga aaacgaccta tgatgaattg tttttaatca 315781 cgaaagaacg cgcctttatt cggccgaatt tcaaagctga taaacattcc attgagattc 315841 cgaatgtatt cgccaaaatt atgggcgtgt cgaaagacaa taaggaatat tggaacaggc 315901 ttcatactct agcggattat caggaaacag aaatggtcag aagctttcca tttacagaag 315961 aaataaagtc gaactatcaa tttcactaca gccacgcact tgatcaagaa gggaacattg 316021 atccggacaa gctgatggca agcaatgtgt ggcagtacaa acagctgccg gcgggcgttc 316081 agactgccat tgccaaaacg atttcgagaa tgtgcaggta cccgcggctt aaagccttgc 316141 atcaggaaca agtcaaggat gttcaaatct atttgtttaa acaaacaaca aacctgcctg 316201 ctaatctgct gaaattgatt caaatgttcg actatgcgca aaccgttccg aaactcgttt 316261 tatatcatac ggaaatgagc ggcggactca cgcgttcgga tgctgccgcc ctgctgttcc 316321 tgaatgaaat cggaatcgat atcatcattt ataatccgcc cggacaccaa gatattgagc 316381 agtttattga agaggatcag tatgatatcc actggctgga tgacatggtg tttcagcagg 316441 actacaaaga gccttcgctt gtgaaaaggc tcttcagaac cattacccaa aaataaggag 316501 agaagaaaag catgacaaca gaaaatcaaa atccgcttgt tctcgataaa aatgaagaga 316561 tttcccagca aaaagctgac gatatccgtc ttcagctccg tcaggaacca gaagtgaagc 316621 ggcttgctca acaaattgac gtcaaaaacc aaatggagct gcttgagtac ggcaaggagc 316681 cggccgttga aatatccaag ttctctgacc gcatcttggg gatgatgaaa acaacaagcg 316741 tgacagactc cggcacaatg ctgactcagc ttgggaaaat catggaccgc ttcgacaaaa 316801 atgattttga tgagccaaag ggattaatgg cgaaaatttt caaacgcggc ggcagcatga 316861 ttgaaaaaat ctttaaaaag tatcagacgc ttggcggaga gattgaaaaa atccacgttg 316921 agatttcaaa atacaaagat gagatgacga agacgaacta cacgctcgat gaaatgtatg 316981 aaaacaatat caaatactat atggagcttg aaaaatacgt cgttgccggg cagatgaaac 317041 tggaagagat gcagtcgatc cttccttcat atgaggaaaa agcggcaagc gggaaccagc 317101 tggcgcaaat gcagctcgat acgttgcgca acggcattca ggcgcttgag gaacgggtgt 317161 atgatcttga catggcacgg atggtggcgc ttcaaaccgc acctcaaatc cgtctcctgc 317221 agcgaggaaa tgcaaagctg atcgggaaaa tcaactccgc gtttatcatt accattccga 317281 ttttcaaaaa cggcattatt caggctgtta cggtaaagcg gcaaaagctt gtggctgatt 317341 ccatgagcga gcttgaccgc cggacaaacg agatgctgaa acgaaatgct gaaaacatct 317401 cgagccaaag tgttgaaatt gcgagaatgg ccggcagacc gagcatagat attgaaacga 317461 ttgaatcgtc ttggaacacg attgtcagcg gcatgcagga aacaaaacaa atcgaagaag 317521 aaaacaagcg cctccgcgaa gacggcgcga gacgaattgc ccagcttcag gataatatta 317581 aaaaagcagc attgcagcaa taataaaaac cccgcttgtg gaacataagc ggggtatttc 317641 aattacatca tttagttaat gacaatgtgt aaagacaggt gtaaacttaa acggtaatca 317701 ttttgcatat cagaggtgtt ggcaatggga aaacaacagc ctatatccca gcgtaaactg 317761 ctgggcgtcg ccggtttggg gtggctgttt gatgcaatgg atgtcggaat attatcgttt 317821 attatcgccg cgctccatgt agagtggaat ctgtcgcccg aagaaatgaa atggatcgga 317881 agcgtcaatt ccatcggcat ggctgcgggt gcgtttttgt ttggtttgct tgctgatcga 317941 atcggccgca aaaaagtgtt catcatcacc cttttatgct tttccatcgg aagcggcatt 318001 tccgcttttg tgacgagctt atcggcattt ctaatccttc gtttcgtgat tggtatggga 318061 cttggcggcg agcttccagt cgcttcaaca ctcgtttcgg aagcggttgt gcctgaaaag 318121 cggggcagag tgattgtgct tttggaaagc ttttgggccg tgggctggct cgcagcggcc 318181 ttgatttctt actttgtgat accaagcttc ggctggcagg ctgcccttct gttaactgcg 318241 ctgactgctt tttatgcgct gtacctgcgg acgagtctac ctgattcgcc gaaatatgaa 318301 tcgctttctg ccaaaaagag gtcgatgtgg gagaatgtaa aaagcgtctg ggcaagacag 318361 tatatacggc cgacggtgat gctgtcgatc gtttggttct gtgtggtgtt ttcttattac 318421 ggcatgttcc tatggctccc gagtgtcatg ctgctgaaag gcttcagcat gattcaaagc 318481 tttgaatatg tcctgctgat gacgcttgct cagctacctg gctatttctc tgccgcatgg 318541 ctgattgaaa aagcgggccg gaagtggata ctcgtcgttt acttgattgg cacagcagga 318601 agcgcctatt tcttcggaac ggcggattcc ttaagtcttc tgcttacggc tggagtgctg 318661 ttatcgtttt tcaatctcgg tgcgtggggc gtgctgtatg cttatacccc ggagcaatac 318721 ccgactgcga ttcgagcaac aggttcagga acgacagcag cgtttggaag aatcggcggc 318781 atcttcgggc ctttgctcgt cggaaccctg gcagcccgtc atatttcgtt ttcggtcatc 318841 ttttcaatct tttgcattgc aatcttactt gcggttgctt gtattttgat tatggggaaa 318901 gaaacgaaac aaactgagct agaataggaa aagcacctct taaaagaggt gctttcagcg 318961 tgtcgacaaa ccctcgcatt cgttgtcagg actgcgcttc ggtgctcaat gcgaagtgga 319021 tcaacggcta aattctcagg cgtcctgcct aaacgccgtc gtcatcacat cctgtgaatg 319081 tccgctccta tgctcgtcct tcctagactt caagggtttt caatcacgct gaaaagattt 319141 tgtcaacaat ctgaggcacc tcttgaatga ggtgcttttt tacaattgcg cccgggctgt 319201 ggattggcgt ttcccggttt tactgattgt ctggtagagc gtcatagaaa gtatgaacag 319261 aatggcagta aatcctgtga cagctccgaa atgctgtgtg ctttgatata aaaaacctgc 319321 aatacttgta ccgacagtgg ttccggcata catagcggca ttggaaaggg aagcgatggt 319381 tcctcgcgca tttggtgcaa tggattgaaa gacacccatc attaacggaa agatgatgcc 319441 agctgtaaag aacgtgagaa aaaagccggc ttctactaaa aacaagtttg gaaagaacgg 319501 aagagcgaaa tagagagcgc ccattagcag catcccgctg atcagtgttt taaacatgcc 319561 cagcttttct gaaacccggc tgccgataag gctcccgagc atatttccca gtccgagtac 319621 aagcatagct gcgccaattt gtgacacggt taaatgataa tccgcggaaa gccaagtacc 319681 cagaaagctg aacgatgcga agtttccggt ttgaaacaga aaataggcaa gcagaatgac 319741 cgatgttttc ggcaatgaaa aaagctcccg ataggggttg acaattgatg ggcgcgccaa 319801 tggttcagaa ggccggatgc caggcatgac cgccgccagg atcaatagaa gaataagcga 319861 gcacgctgac aaaacgaaaa atggcgtatg ccatgtaaag gaagcgagaa accctccaat 319921 aggaagtccg agcatttgtg aagcggccaa acctgctgtc gcaatcccca tgccttttat 319981 gatctgagaa ggctggacaa tgactgggat ggacgcccaa atttgaggcg tcacaaacgc 320041 agcgctaacg cctgcggcaa aacggaacag gcacatggcg gcaaaagagg gagcgatgcc 320101 gcataaaaat gtggatacga taaagcctgc aagtccccac agcatgactg ttttcctgtt 320161 cagccggtct gagattgggc ctgcaatgaa agcgaagagt gcataaccga gtgcataagc 320221 actgaccatc cagcctgaca aatcagtaga gacatgaaac tgatcctgta aaagggggag 320281 aagcggcgaa agcaaaaagg tatccgtgcc aatgacaaac atgacactga agaaaagcca 320341 aatgcgattc aaattttatc actcctattg ttttataact ttaaaactat gaaacagata 320401 tgtatagaga aaaccctttg ttagagggtt tccaaaaagc caggcaggta tgtttgaaat 320461 gtgtcttcac gcagactgac gtattttgtc cgcgaatctt tccgggttgc cgtcaatccc 320521 gcttcacgca gcgttttaaa atgataagat gccgtggttt tgacaatatt gcacttttca 320581 cctacttcac cgcagctgag ttcttttccg ctgacataaa gcgtacgaat aatggcaagc 320641 cttgattcat cagacagtgc tttaaaaatt tgcgctctga tttgatcatc tgattgtttc 320701 atagtcatga aactataata cataatgggt gttgaaaaag caacttattt ttccagtaaa 320761 ggagcaggaa gtcataagag gaaggaggaa ttcaattcca ataaaagcgt tttcaactaa 320821 aggtaggaga aaaatcaccc gtaaaataca atcatatagg aggattacag agcatttaga 320881 agcataaata agatcatgtg gtcacatgga tgtttataaa gaaatggtac agaataaaag 320941 agaatatgct gtttgtgtgg gaagttacat aaatgttacg gtaataaaga ttgcttaata 321001 tggagggaaa atatgagtgt agatgagaaa ccaattaaga taaaagtcga gaaagtctct 321061 aagatttttg ggaaacaaac aaagaaggca gttcaaatgc ttgccaacgg aaagacaaaa 321121 aaagagatcc tgaaagcaac cggatcaacc gttggggtta atcaggcaga ttttgaagta 321181 tatgatggtg agatatttgt catcatgggt ctatcaggga gcggtaaatc aactttagta 321241 cggatgttaa accggcttat tgaaccgact gccggaaata tttacattga tggtgacatg 321301 ataacaaata tgtcaaaaga ccagctccgg gaagtccgcc ggaaaaaaat cagcatggtc 321361 ttccaaaagt tcgctctgtt tccgcacaga acgatacttg aaaacacaga atacggactg 321421 gagcttcaag gtgtagacaa acaagagcgg cagcaaaaag cgcttgagtc tcttaagctc 321481 gttggactgg aaggatttga acaccaatat cccgaccagc tttccggcgg gatgcagcag 321541 cgtgtcggcc ttgcccgcgc gttgacgaat gacccggaca tccttctgat ggacgaagcg 321601 ttcagtgcgc tcgatccact gattcgtaaa gatatgcagg atgagcttct tgatcttcac 321661 gataatgtcg gaaaaacaat tatctttatt acgcatgact tggacgaagc gttgcggatc 321721 ggcgacagaa ttgtcctaat gaaggacggc aacatcgttc aaatcggcac gcctgaagaa 321781 atcctgatga atccatctaa cgaatatgtt gagaaattcg tcgaagatgt tgatttgtct 321841 aaagtcctca cagcaggcca cattatgaaa cgcgctgaaa cagtgcggat tgataaaggg 321901 cctcgcgtag cattgacact gatgaaaaac cttggaattt cttcaattta tgcagtggat 321961 aaacaaaaga aattattagg tgttatctat gcgtctgatg cgaaaaaagc ggctgagtct 322021 gatttgtcac ttcaagacat cttgaataca gaatttacga ctgtaccaga gaatacgtat 322081 ctgactgaga tttttgacgt tgtgtccgat gcgaatattc caattgcggt tgtggatgag 322141 aagcaaagaa tgaaaggaat tgtcgtaaga ggcgcgctga ttggcgcact tgccggcaat 322201 aacgagtata tcaatgctga aggcactaac gaacaaacac aagatccttc tgcacaggag 322261 gtgaaataag atggatagac tgcctagaat acctttagca gatattattg accgttttgt 322321 tgactggatt acgatgacgt ttggcggatt cttcgacgga atcgctaacg gattggccgc 322381 ttttgtaaat ggaattgtca ccggtcttgg atttattcca tctattttgt taacgattat 322441 tttcgccgca cttgcgtggt ggatcagtac aaggggaatt gcgttattta cgttgattgg 322501 attcctcctg atcgattatt taggatattg ggacccaatg ctgcaaacat tggcgcttgt 322561 tttgacatct gtgattattt cgattgtggt cggggttccg atcggaattt gggcgtctca 322621 gaaagaaacg gttcgccgta ttgtaacgcc aattcttgat ttaatgcaga caatgcctgc 322681 tttcgtatat ctattgccgg cgattttctt ctttaacatc ggtgttgtgc cgggtgttgt 322741 tgcatctgtt atcttcgcga tgccgccgac aatccgcatg actgttctcg gtattaaaca 322801 agtgccggcg gatttgattg aagcgactga ggcattcggt tctacaacag ctcagcgttt 322861 gtttaaagtt cagctcccgc ttgcgacaaa aacgattttg gccgggatca accagagcat 322921 catgcttgcg ttatcaatgg ttgttatcgc cgcaatggtc ggtgcaccgg gacttggttc 322981 tgaagtatac agtgccgtta cacagctgaa aaccggggtc ggagtagagg ccggtatcgc 323041 catcgttatc gttgccatta ccctggaccg tattactcaa aatattaaag tgaagaagaa 323101 aagcaggggg aatgcctgat gcttaaaaaa atcataggca tcggcgtttc cgccatgctg 323161 gcgctctcac ttgcggcttg cggttcagaa aacgatgaaa atgcatccgc agcagaacaa 323221 gtgaataaga ccatcatcgg gattgacccc ggttcaggga ttatgtccct gactgacaaa 323281 gcgatgaagg attatgacct gaatgactgg acattgattt cagcgtcaag tgctgcgatg 323341 accgctacgc ttaaaaagtc atacgaccgt aagaaaccga ttatcattac aggatggaca 323401 ccgcactgga tgttctccag atataagctg aaatatctcg atgatccgaa acaatcttat 323461 ggcagcgcag aggaaatcca tacgatcaca cgcaaaggct tcagcaaaga gcagccgaat 323521 gccgcaaagc ttctgagcca gtttaaatgg acgcaggacg aaatgggcga aatcatgatc 323581 aaggtggaag aaggcgagaa acctgccaaa gttgctgctg agtacgtcaa taaacacaag 323641 gatcagattg ccgaatggac aaaaggcgtt caaaaggtga agggagacaa aatcaacctt 323701 gcctatgtgg cgtgggacag tgagattgca agtacaaacg tcataggcaa agtcttagaa 323761 gacttgggct atgaggtaac acttactcag gtagaggctg ggccgatgtg gactgcaatt 323821 gcgacgggaa gtgcggatgc atccctttcc gcatggctgc cgaataccca taaagcatac 323881 gccgctaaat ataaaggcaa atatgatgat attggcacca gtatgactgg tgtgaagatg 323941 gggcttgttg ttcctcaata tatgaaaaat gtcaactcaa ttgaagattt gaagaagtaa 324001 tcaaaaaagc agcctgtgtc aggctgcttt ttttgcgtta agaagcgtta gcggcagcaa 324061 gtgattccgc cttctgaaat gttttgagca cggcgttcgc caaaatatga atgccggtaa 324121 acatcgcatt tctgtcaaag gtcatgtgcg gatgatggag ccccggctgg agcccgcagc 324181 ctagtccgag catcgttgtt ttcagattcg gcaccttcac ggcgtaaaaa tggaaatcct 324241 cgccgccggt ggtgacaagc gggtcatcaa gccgctcagc cccgatgatt tccgtaatgg 324301 cttctgccat gatcgcttca gcttctttat tttgtgttgc cgcaggaagg ctgtgttctt 324361 tgtgcagctc gatctttgcg ccaaatgcag cggcggccgc ttcacaggct ctttctgttt 324421 cggcgattaa tgcctccatg gcttcattgg tctgtgcgcg caaatcaagg ctgaacgatg 324481 cttttcctgg aatgatgtta gagctttcac cgccggcttg cagttttgtc attttgacgg 324541 tatgcgggat ttgcgggtca atatgaatga gtccgagctt gtgtacaaga aatgccgcaa 324601 tttcaatgct gtttttcccg aggtgcggac gggcgccatg agcctcttcc ccgatgatcg 324661 ttccctcaat gtgctggctt gatccgtgca gaatagaagg agcgcagcgg ccgttctgtg 324721 tttcctggat cggacggacg tgaacgccat acaaatagtc gatatcatca agcacgcctt 324781 cttctatcat tttcaaggcg ccgccgcctt tttcttctgc cggctgaaag ataaaacgga 324841 ttgtgccctt cggaagctca ggttgttttt ttagcagcat taacgtgccc aatgccattg 324901 tcatatgtga atcgtgtccg caggaatggt tggcgcgaaa tgtgccgtta acctcctgcc 324961 acagcgcgtc aatatcagcg cgtaccgcta caacaggtga gcctgagccg atttcgccga 325021 caaccccggt gcagtctgaa aacgtgcgcg tccggcaccc taaatcctca agcttttgtt 325081 tcaaaaatga agttgtctca tattccttcc agctgacttc agggttcgcg tgcagatgct 325141 cgaagatgtc cataatggtt tgtttcattt cttctgaaag cttttgcatg gtaagaaata 325201 cctccttcta tcagaatgaa tttttacctt ctttacttta tttatattga aacaggaaga 325261 taggctgtat ataatatagc acatattgct actattcaga ataattaata ttttcaaaca 325321 gaggggatgg atcgaaatat gagtatgcca gcagccgaaa cacagcctaa gaaaaaacgt 325381 atgacattta aaatgcctga cgcctatgtc ctcttattta tgattgcttt catttgcgca 325441 atcgcttcat atattgtgcc ggcaggtgaa tttgaccgcg tgacaaaggg ggatgtcacg 325501 accgctgttc cgggaagcta tcattcaatt gaacagtctc cggtcagatt gatcagcttt 325561 tttacttctc tacaggatgg aatggttgga tcagcaccca tcatctttct gattttattc 325621 acaggcggca ccattgctat tctagaaaaa acgggtgcca tcaatggcct gatttacaat 325681 gtcatcagca aattccgcac aaagcaatta ttatttattt gtattgtcgg cgcattgttc 325741 tccattctcg gaacaaccgg gattgtcgtg aattcagtta tcggttttat ccccatcggc 325801 ctcattgtgg cacgatcctt aaaatgggac gcagtcgcgg gagccgctgt tatatacatc 325861 ggctgctacg ctggatttaa ctccaccata ttatcaccgt caccgctcgg tttatcacaa 325921 tcaatcgcgg agctccctct tttctcagga atcggcctgc gagttgtgat atacatatgc 325981 tttttgctgt cttctattat ttatatctat ttgtatacga gaaaattaaa aaaatcaaaa 326041 gatgccagtg tgttaggaac agattggttc cctgcggcag gaatgggcga agccggtaaa 326101 gaagaagatc agtcagtgcc gtttaccgtt cgccataagc tgattttggc tgtggcggga 326161 ctctcacttg tcggattttt atacggcgct ttgaagcttg gctggtcaga ttcccaaatg 326221 gctgcgacat ttatttttat ttctgtcctt gccggtttaa taggcgggct tgcggcgaac 326281 gatattgcca aaaccttcat tacgggctgc caaagtcttg tatacggggc gctgattgtc 326341 gggatggcac gaagcatttc cgttatcctt gaaaatggaa agcttctcga tactgtcgtc 326401 aatgctttgg cttcactttt ggatggattc agcccgattg ctggggcaat cggcatgtat 326461 atcgccagtg cgctgcttca ttttctcatc tcttcaggtt ctggcgaagc cgttgtattt 326521 attccaatcc tggcgccgct cgctgatttg atgggaatca cgagacaggt tgcggttgaa 326581 gcggttatgc ttggagaagg ggtcgtcaac tgtgtgaacc cgacatccgg cgttctcatg 326641 gcggtgcttg ccgccagcgg tattccgtat gtcaagtggc tgcggtttat ggtgccgctt 326701 gctctgattt ggttcttgat cgggcttgtc tttatcgtga tcggagtcat gatcaattgg 326761 gggccgtttt aacgattgct gcccgccggc ttgtacggcg ggcttttgag ttattcattg 326821 cagaagcgca ggctgttatt gtaacatgta agccataagc cattcgtaaa agtgcgggag 326881 gaaggtcatg aataatctgc gtaatagact ttcaggcgtg aatgggaaaa ataagagagt 326941 aaaagaaaaa gaacaaaaaa tctggtcgga gattgggatg atagcgggag catttgcgct 327001 gcttgatgtg atcatccgcg gcattatgtt tgaatttccg tttaaagaat gggctgcaag 327061 ccttgtgttt ttgttcatca ttatcttata ttactgcatc agggctgcgg catccggaat 327121 gctcatgccg agaatagaca ccaaagaaga actgcaaaaa cgggtgaagc agcagcgaat 327181 agaatcaatt gcggtcgcct ttgcggtagt ggtgcttacg atgtacgaca gggggattcc 327241 ccatacattc ttcgcttggc tgaaaatgat tcttcttttt atcgtctgcg gcggcgttct 327301 gtttctgctt cggtatgtga ttgtgaagct ggcttacaga agagcggtaa aagaagaaat 327361 aaaaaagaaa tcatcttttt tgtttggaaa gcgagggaag cgttcacagt ttcgggcagc 327421 tttttttata ggaacattga tttgtattca ctctgccaag ttgttttgat agagtgattg 327481 tgataatttt aaatgtaagc gttaacaaaa ttctccagtc ttcacatcgg tttgaaagga 327541 ggaagcggaa gaatgaagta agagggattt ttgactccga agtaagtctt caaaaaatca 327601 aataaggagt gtcaagaatg tttgcaaaac gattcaaaac ctctttactg ccgttattcg 327661 ctggattttt attgctgttt catttggttc tggcaggacc ggcggctgcg agtgctgaaa 327721 cggcgaacaa atcgaatgag cttacagcac cgtcgatcaa aagcggaacc attcttcatg 327781 catggaattg gtcgttcaat acgttaaaac acaatatgaa ggatattcat gatgcaggat 327841 atacagccat tcagacatct ccgattaacc aagtaaagga agggaatcaa ggagataaaa 327901 gcatgtcgaa ctggtactgg ctgtatcagc cgacatcgta tcaaattggc aaccgttact 327961 taggtactga acaagaattt aaagaaatgt gtgcagccgc tgaagaatat ggcataaagg 328021 tcattgttga cgcggtcatc aatcatacca ccagtgatta tgccgcgatt tccaatgagg 328081 ttaagagtat tccaaactgg acacatggaa acacacaaat taaaaactgg tctgatcgat 328141 gggatgtcac gcagaattca ttgctcgggc tgtatgactg gaatacacaa aatacacaag 328201 tacagtccta tctgaaacgg ttcttagaca gggcattgaa tgacggggca gacggttttc 328261 gatttgatgc cgccaaacat atagagcttc cagatgatgg cagttacggc agtcaatttt 328321 ggccgaatat cacaaataca tctgcagagt tccaatacgg agaaatcctg caggatagtg 328381 cctccagaga tgctgcatat gcgaattata tggatgtgac agcgtctaac tatgggcatt 328441 ccataaggtc cgctttaaag aatcgtaatc tgggcgtgtc gaatatctcc cactatgcat 328501 ctgatgtgtc tgcggacaag ctagtgacat gggtagagtc gcatgatacg tatgccaatg 328561 atgatgaaga gtcgacatgg atgagcgatg atgatatccg tttaggctgg gcggtgatag 328621 cttctcgttc aggcagtacg cctcttttct tttccagacc tgagggaggc ggaaatggtg 328681 tgaggttccc ggggaaaagc caaataggcg atcgcgggag tgctttattt gaagatcagg 328741 ctatcactgc ggtcaataga tttcacaatg tgatggctgg acagcctgag gaactctcga 328801 acccgaatgg aaacaaccag atatttatga atcagcgcgg ctcacatggc gttgtgctgg 328861 caaatgcagg ttcatcctct gtctctatca atacggcaac aaaattgcct gatggcaggt 328921 atgacaataa agctggagcg ggttcatttc aagtgaacga tggtaaactg acaggcacga 328981 tcaatgccag gtctgtagct gtgctttatc ctgatgatat tgcaaaagcg cctcatgttt 329041 tccttgagaa ttacaaaaca ggtgtaacac attctttcaa tgatcaactg acgattacct 329101 tgcgtgcaga tgcgaataca acaaaagccg tttatcaaat caataatgga ccagagacgg 329161 cgtttaagga tggagatcaa ttcacaatcg gaaaaggaga tccatttggc aaaacataca 329221 ccatcatgtt aaaaggaacg aacagtgatg gtgtaacgag gaccgagaaa tacagttttg 329281 ttaaaagaga tccagcgtcg gccaaaacca tcggctatca aaatccgaat cattggagcc 329341 aggtaaatgc ttatatctat aaacatgatg ggagccgagt aattgaattg accggatctt 329401 ggcctggaaa accaatgact aaaaatgcag acggaattta cacgctgacg ctgcctgcgg 329461 acacggatac aaccaacgca aaagtgattt ttaataatgg cagcgcccaa gtgcccggtc 329521 agaatcagcc tggctttgat tacgtgctaa atggtttata taatgactcg ggcttaagcg 329581 gttctcttcc ccattgaggg caaggctaga cgggacttac cgaaagaaac catcaatgat 329641 ggtttctttt ttgttcataa atcagacaaa acttttctct tgcaaaagtt tgtgaagtgt 329701 tgcacaatat aaatgtgaaa tacttcacaa acaaaaagac atcaaagaga aacataccct 329761 ggaaggatga ttaatgatga acaaacatgt aaataaagta gctttaatcg gagcgggttt 329821 tgttggaagc agttatgcat ttgcgttaat taaccaagga atcacagatg agcttgtggt 329881 cattgatgta aataaagaaa aagcaatggg cgatgtgatg gatttaaacc acggaaaggc 329941 gtttgcgcca caaccggtca aaacatctta cggaacatat gaagactgca aggatgctga 330001 tattgtctgc atttgcgccg gagcaaacca aaaacctggt gagacacgcc ttgaattagt 330061 agaaaagaac ttgaagattt tcaaaggcat cgttagtgaa gtcatggcga gcggatttga 330121 cggcattttc ttagtcgcga caaatccggt tgatatcctg acttacgcaa catggaaatt 330181 cagcggcctg ccaaaagagc gggtgattgg aagcggcaca acacttgatt ctgcgagatt 330241 ccgtttcatg ctgagcgaat actttggcgc agcgcctcaa aacgtacacg cgcatattat 330301 cggagagcac ggcgacacag agcttcctgt ttggagccac gcgaatgtcg gcggtgtgcc 330361 ggtcagtgaa ctcgttgaga aaaacgatgc gtacaaacaa gaggagctgg accaaattgt 330421 agatgatgtg aaaaacgcag cttaccatat cattgagaaa aaaggcgcga cttattatgg 330481 ggttgcgatg agtcttgctc gcattacaaa agccattctt cataatgaaa acagcatatt 330541 aactgtcagc acatatttgg acgggcaata cggtgcagat gacgtgtaca tcggtgtgcc 330601 ggctgtcgtg aatcgcggag ggatcgcagg tatcactgag ctgaacttaa atgagaaaga 330661 aaaagaacag ttccttcaca gcgccggcgt ccttaaaaac attttaaaac ctcattttgc 330721 agaacaaaaa gtcaactaac cgcaacttta gagtaaaggg ctgattgtca atgtgggagc 330781 agttgtatga tccgtttgga aacgagtatg tgagcgcact tgtggcgctc actccgattc 330841 tcttttttct tttggcttta actgttttga aaatgaaagg cattcttgcg gcatttctta 330901 ccctagccgt cagtttcttc gtctccgttt gggcatttca tatgccggtt gaaaaagcga 330961 tttcttctgt tttgttagga atcgggagcg ggctgtggcc cattggctac atcgtcctga 331021 tggcggtgtg gctgtataaa atcgccgtga aaaccgggaa atttaccatt attcggtcca 331081 gcattgccgg catttcgcct gaccaacgat tacagctatt attaattggt ttttgtttta 331141 acgcgttttt agaaggcgcg gccggttttg gtgttccgat tgcgattagt gcggcgctgc 331201 tcgtcgaact tggttttaaa ccgttaaaag cggcggcgct ctgcttgatt gcaaacgctg 331261 cctccggagc ctttggggcg attgggattc ctgtcatcac aggggcgcag attggtgatt 331321 tgtctgctct tgagctgtct cggacattaa tgtggacact gccgatgatc tcatttttaa 331381 taccattcct gcttgtattc ttattagacc gaatgaaagg aatcaaacag acatggcccg 331441 ctcttctggt tgtgagcggt gggtatacag cggttcagac actgacaatg gcggtgctcg 331501 ggccggaatt agcaaacatt ttggcggcct tattcagcat gggcgggctt gccctcttcc 331561 tccgcaaatg gcagccgaaa gagatttacc gcgaggaagg ggccggcgat gctggtgaga 331621 aaaaggcata ccgtgccgct gacattgcga aagcgtggtc tcctttctac attttaactg 331681 cggcgatcac catctggagc cttcctgcct tcaaagcgct tttccaagaa ggcgggctgt 331741 tatatcaatc aacgctcctg ttcaaaatgc cttttctgca tcagcaaatt atgaaaatgc 331801 cgccgattgc gccatctgcc atgccgttag atgcagtctt taaagttgat ctgctgtcag 331861 cgactggtac agcgatttta gcggcggtca tcgtgacagg gctgttcagc aaaaagttct 331921 cctctcggga tgcctttgct tccttgaagg agacgggaaa agagctgtgg gtgccgatta 331981 tgacgatctg cttcgtgatg gggtttgcca atctggccaa cttcgcaggg ctcagctctt 332041 caattgggtt agcattggcg aaaacaggag acctgttccc gtttgtcagt cctgttctcg 332101 gctggattgg cgtgttcatc accggttctg ttgtcagcaa taatgctttg ttcggccatt 332161 tgcaggttgt cacgggagcg cagatcggtg cgggttcaga tttgctgtta gccgcaaata 332221 cggcgggcgg tgtcatggcg aaacttgttt ctcctcaatc tatcgccatc gctgccgcag 332281 cggtcggcca aacaggcaag gaatctaaac tgtttaaaag gacagtggcg tacagcctga 332341 ttctgttatt gatcatttgt atatggacgt ttattcttgc aagattagga gtgtaataga 332401 aaaaagcagt acatgcccag catgtactgc tttttttatg ttaatttgct ttctttgtca 332461 tttcggctgt tgttttcact ctggcttttc ccataaataa aatggtaacc gccgcgagga 332521 caattggaat caaagcgagc aaaaagacat acgtgatact tgatgacatc gcgtcaataa 332581 tgcgattcag gatcgcatca ggaatctggg aacgtgttcc cgcttggaat atctcctgcg 332641 ggtcgccaat attttgcgca gcgcctgatc ccgctgagcc tttcataccg ctgaaggcgt 332701 cattcagctt gtttgtgaat acgtttgttt gcaccgttcc gaaaatggtg acacctaagg 332761 tcatgccaaa tgatcgcaaa aatgaatttg tagagtttgc cgttccccga aagcgaggtt 332821 caagatcatt catcgatgcc gccggcagca gggagaagtt aaagcctaca ccaaagcctg 332881 aaatcatcat aaagactgtc agccataccc gtgctgtgtc aggcgtcata ttggaaagaa 332941 gcagcatgcc gataaagaaa gctataacag atatcagcat caaattgcgg aagcttgcct 333001 tcgtttggaa gatcccgccg atcatgcttc cgatgactga tccaatcatc atcggcgtca 333061 gaatgaagcc cgcgcttgtc gccgagctgc cgtagaccgc ctgaacgaaa atcggaataa 333121 ataccgctaa aataataaat gttccgccat acaggaaagc gagaatctgt gctgtggcaa 333181 acaagcggtt cttaaacatc cagaaagaaa taatcggctc ttctgctttt ctctccacaa 333241 taaaaaaggc aatgaagaaa acggcgaata caataaacag cccgatgatc tgaatggagt 333301 tccaatcgta tgttttgccg ccaagctcaa gggcgaacat caggcataca atggatacga 333361 ctaaggtaat cgcgccgccc cagtctattt tctgctttct gtgctccaga gattctttgt 333421 agtagcgaat aatgaaaaac aatgacaatg cgccgatcgg cacattgatg taaaacaccc 333481 agtgccagct gatcgaatct gtaatgatcg cgcctaagag cggaccaaga acactggata 333541 atccaaatac agcaccgaac atgccggaca tttttccgcg tttttccggc ggaaacaaat 333601 caaagataat ggtaaaggca atcggcagga gcgcgccgcc tccgatccct tgaatggccc 333661 ggaagatgat cagctgattc atcgtctggg caatcccgca taaagcagaa ccgattaaga 333721 aaaaaataag tccaaacagg aaaaaacgtt ttcggccgta catatcggaa agcttgccgt 333781 aaatcggcat gccagccata accgccacca tataggatgc cgtcacccag gcaaatttat 333841 cgaagcttcc aagatcggct acgatattgc ccatcgcggt ggcaacaatc gtattgtcca 333901 ttgcagacat caagatgccc agcaggagac cgaggaccac aaatttggtg gaagcctgtt 333961 ttgctgttgt tgtgtccatt tgttctacct cctcttactt ttctatgtaa gttctgatat 334021 catgataata gtttgattgt tgaatatctc gattatcaag ataaactcga ttttataggg 334081 aggactgtca gttgtcaaca agaaattcca gaagtgagtt ggaaaagact gctgttcagc 334141 tttttcgaaa actgggcaca agaacggttc tgtttcatca ggcagccgct caagctctcg 334201 gtctgtttcc caccgatttg aaatcagctg acattttaaa tgaagcaggg ccgatgacgg 334261 ccggagagct ggggaaaaaa accggcctca gcacgggttc cgtcacggcg cttgttgacc 334321 ggctggaaaa agcggggtat gtggctcgtg aaaaggaccc gaacgatcgc aggagagtcg 334381 taatcgtccc tttgactgct tcgaaaaaac atataaagga tttgttccgt cctctgtctg 334441 agtcaacgat ggatttgtgc cgcgaatata cggaagagga gctggaactc attttcagtt 334501 ttgtaggcaa agctgccgat attatggagg aagagcttga acgtctgaaa cagtaagtga 334561 atttgtgcat agcttggccc gttcccgaat aaattgtaca agttacataa gagaagggag 334621 tacgggccgg tgaacatttt tttgagctat attgtgctgg gactgtcctt gtctgcgcct 334681 gtggggccag tgaatgcggc gcaaatagac aaaggaatta aaaacggttt ttggcatgca 334741 tggattttcg gtttaggcgc catgacagcg gatgggctgt acatgctttt tatctatttc 334801 gggctgtcgc agttcttgac cgctccattt gtgaaaacgt ttttgtggct gttcggcttt 334861 tttgtcctga cctataccgg aattgaaacg ctgaaaaacg tcagagaacc gatggatgtg 334921 cgaagctcgc gggggaaacc gtcatacagg aaaacattcg catcgggttt tctcatttca 334981 ttgtcaaacc cattgagcat ccttttttgg cttggaattt acggaagcat tcttgcgaaa 335041 acagcagagg cctacaatat gaatcagctt ctaatctata gctccggcat catgatcggc 335101 attttaatct gggatttctg catggctatc acagccagta cgttcagaaa cctgcttcat 335161 gaaaagctat tgagaggatt gaccggaatc gccggtgtat ccctccttgt gtttggcttt 335221 tactttggtt atcagggcat caaacagtta ttgggctgat tcatgaagga cagtcacctg 335281 ccgcttccag ttttaatata gtatccagat gatactggag gtggatcaat ggtgaatggg 335341 atttacacca aaagttttct ggaacgtatt caggaagagc ttcctgaatg gcaaagaatc 335401 gcttttgagc tgctggcaga aactctgggg gacgacgcgg atacatttcc gtgcattccc 335461 ggacgccagg cgtttctgac tgatcagctt cggattgctt ttgccggaga tccgcgggaa 335521 aaccgcacag cggaggaact ggctccgttg cttgcggagt acggcaagat atcgcgggac 335581 acgggaaaat acgcatccct cgttgtgttg tttgatacac cggaagattt ggcggagcat 335641 tattcgattg aagcgtatga agagctgttt tggcgctttt taaatagact gagtcatcaa 335701 gacgaaaaag aatggccgga agacattccg gccgatcctg agcattataa atgggagttt 335761 tgttttgacg gcgagccgta tttcattctg tgcgctacac cggggcacga ggcaagaaga 335821 agccggagct ttcctttttt tatggtcacg tttcagccaa ggtgggtgtt tgatgaccta 335881 aatggatcaa ctgcatttgg ccgtaacatg agcaggctga tccgatctcg tttagaggcc 335941 tatgatcagg ctccgattca cccgcaatta ggctggtacg gaggaaaaga taatcgtgaa 336001 tggaagcagt atttcctccg tgatgacgaa aaacaggtat cgaagtgccc gttttcttat 336061 ttaaagaaca tgttcaacaa aatgaaataa atcaaggact ggcagggcga tctttatgac 336121 cctgcttttt ttgatagatc atggtaacga tggcgataat cacgagaaaa cctatgctga 336181 cgaaaaaacc gggccggctt gatttttcaa acaatgtacc ggacacagct gcagcaatca 336241 gaaccatcgc taaataaatt tgcgtttttc ccatgccctc gggatcagtc agctttttgc 336301 tggagaacag gataaacagc caagtgtata aaagcataag ccccgcagct gttgtcatat 336361 gctcataaat gtttttaggc agcactaacg acaaaataat ggagaggaca agccccgcaa 336421 acgtcagccc aagtgccggc cagcatattt ttttgccttc ctttagagta aagcatttcg 336481 gcgcgtcgcc gtcatcagcc attgtacaaa gcaatgtcgt aaccgcaaat agcgaagcga 336541 caagggtcga gaaccctgcg atgatgaaaa tcccgttaaa tatatcaagg atgatctcaa 336601 ggttatatcc ttttaatgac gtaatgaacg gactgtcctg ttcagtaaac gtgtgtaacg 336661 gaaccaaaag cagagcaagc ccgattgaaa tgatataaat aatcgccagc gtcgccagca 336721 tcagtttccc tgatttagac gcttcctcag gtttttttaa gtgaaccgcc atcagcccca 336781 tgacctcaat tccgccaaaa gcgtaaaacg cgtagattaa acctgtccac agccccatgg 336841 cgccgtatgg gaaaaactca ctcgtcttat ttggaacatg tatgccatga tttccgccgg 336901 acaggatacc gcataaagcc aggatggcaa tgacaataaa cataaaaata gcagctgttt 336961 taatgactgc cagcacgttt tctgtttttt caaagacgga caggccggtg aaaataataa 337021 ggagcccaag tactgcgtag attgaggcaa acacccatag cggcacttga ggaaaccaat 337081 gcttcgtaaa gagcgaaatg gctgtcagct ggcttccggt aatcagcatt tctgatgtcc 337141 agtacaccca gccgttgctg aagcctgccc atttgccgaa tgcttttcgg gcatacgcac 337201 aaaacgagcc cttttccggc tgcttcgccg atagcttggc gagctgttca aagacaaaat 337261 acgtaccgat ccctgcgatc agaaatgaaa ggagaacgga aaaaccgctt tttacaattg 337321 cgatgctgga accgagaaag aagcctgttc caatcgtgca gccgactccg atcagtgaca 337381 gctgccacca agccagattc ccttttggct ggtctttttt tgtttggctc attatttatt 337441 caaccccttt tatctaaggt tagattgtga tctgtccaaa gcttatatac atcggatttt 337501 tgcctctttt tacatggaga aggaagcaga cgctcatact aatgaaaaaa ggagcaaacc 337561 aatgacacag caatatattg tggagccgaa aaaagggctt gggctgaagc tgaaaaaggg 337621 gcagatttta aaggtggttg atgtagaagg gcagcaggtg gctgattttg tcgcatacca 337681 tgccaaggat ttttatgaac accttgatca gggagcgacg atagacgcca atcactccat 337741 tcatgtgaag gtcaacgacc atctctactc caacctgtat aagccgatgt taaccctgat 337801 tgaagatacg gtcggcaagc atgatctgct gttgcccgcc tgccgtcctg atatgaacag 337861 gctcttatat gggaagcaaa aggatgagtt tcaggatacg tgctatgaca atatgaaccg 337921 tgcgcttgag cagtttggcg taccgaagcc ccacatgcat tacccatttg cgatttttat 337981 gaatactgtc cttgatgaga aagggaatct gtctgtggaa acgccgcttt cgaatgccgg 338041 agattatgta aggctcaggg cggagatgga tttaattgtc gcgttttctt cctgcccgat 338101 tgaaaaaggg aaatgcaatg gcgacagtgt gacatccata cgggttgaag tcagctgatc 338161 tctcttgttc acagtgaatg aagacctgtg ctatatttaa tagggataca taacagtcat 338221 gattcatttt cattgattta gggaaatgat cagtaataag ggaaaatgta caggaggaat 338281 gattgggatg agcatgcagg aaaagattat gcgtgagtta catgtgaagc cctcaattga 338341 tccaaagcaa gaaattgagg accgagtcaa ttttttaaaa caatatgtaa agaaaaccgg 338401 tgctaaaggc tttgtattgg gaatcagcgg gggccaggat tcaacacttg cgggaagact 338461 cgctcagctt gcggtggaga gcattcgcga ggagggcgga gacgctcaat ttatcgcggt 338521 ccgtcttccg catggcacac agcaggatga agacgatgcc cagcttgctt tgaagtttat 338581 taagccggat aaatcatgga agtttgatat taaatcgaca gtcagcgctt tttctgatca 338641 gtatcagcag gaaacaggcg atcagctgac ggactttaat aaaggaaacg taaaagcaag 338701 aacaagaatg atcgcgcaat acgcgatcgg cggccaggaa ggtcttcttg tgttaggaac 338761 agaccatgct gctgaagcag tgactggttt ctttacgaag tacggtgacg gcggagcaga 338821 cctcctgccg ctgacaggct tgacgaagcg ccagggaaga accttgctga aagagctggg 338881 tgcaccggaa cgcttatact taaaagaacc gactgccgat ctgctcgacg aaaaaccgca 338941 gcagtcggat gaaacagagc ttggcatttc ctacgacgag attgacgatt atctcgaagg 339001 aaaagaagta tcagcgaaag tatcagaagc gctggaaaaa cgctacagca tgactgaaca 339061 taaacgccag gttccggcgt ctatgtttga tgactggtgg aaataagttg aagaaagccc 339121 gctctcggag cgggcttttg tcgtgtacag aagctttatt tgatgcggat atgattcagc 339181 tttaccatta atctgtcggc gaaccttcgg aggctgcctc ttgtatcagg atctaatggg 339241 agttcggctc tcgcggcaat gttctctgcc acatcctgaa tcgacaggtt gtctgtttga 339301 atgtggtcct caaaaatggg tgatgataat ccttcaacac agcggtcaat ttgtttggcg 339361 gcccatgagt tttttccttc tgctctggtg cgcagccttt ttaacaaggt ttcctttgaa 339421 gccattagtg taaagtggtg aacgatcctg ccttcctgtc tgagcctgcc gatgatctca 339481 ttgaagtatt cagggtgtac aatcgtcata ggcacaataa ggatgccgcg gtatgtatct 339541 gtcagagaag ctagcaaact gtaattgaac gcccgccata aaggatagct ttgaaaatcg 339601 tcctttgcga tctcctgcgg caccatggag cgcagcgcaa aacccatttt ctcgggatca 339661 tacacgtaag atgggttcag ccttctgtgc agttcgaagg ctgtttgtgt ttttcccgaa 339721 ccgaatgccc cgtttatcca aatgatcatc gccatttctc ccttcctatt tatcatacag 339781 aaaaagaccc ttccatcgaa gagtcagctg gaaaaacaat aaaggcggaa ggttttaacg 339841 cttttttgcg tcgaagtatt aaaatacctg cagaaatgtt gtacaatgaa tgtcattcag 339901 gcaaaaatgg ctacaacaaa gcgcactata agcttgaccg gtaaagccgg tatctatata 339961 aatattcgct aaataagcat ataatgaata tataatttca ttccttagga ggatttcgcc 340021 gaagatgaac gctaaacgag ccatcccagt aagagaaaga aatatcgtcc tgatcggatt 340081 catgggtgta ggaaaaacaa caatcggcca attggtcgct aaaaaattat atagagattt 340141 tattgatatt gaccagcaga tcgaaaagga tttcaatatg tcaattcctg agatatttga 340201 gaaaaaggga gaagactttt tccggaaaac ggagaaggaa tatattttag acatctgcca 340261 tcataaacga ttcaaaatcg tatctctggg cgggggatct tttaaacaag aagaaatcag 340321 aaattgctgt ctggaaaact gtctcgtgct tcatctggac ctgtcatggg agaactggaa 340381 gcagcgcgcg gatttattga tcgaaagccg ccctgtactg cataaccgtt caatggatga 340441 aatggaacag ctgtttaacg aaagaaaagt catttatgac aagcacaatt caaaagtggc 340501 aacagacaac ctttccccgg aagaggttgc cgattacatt gttgagacat taaaaattgg 340561 ctgggatctt tatcagccga tgtaaaaagc cgtgcgcagc gcacggcttt ttttatcgtt 340621 ttatcccttg tatcaaaatc gcttttaaac aaaaggagat gggctgtccg ttttggttca 340681 atgtaataca gaacgtgtcg cgtgcttcgt ctgatgcgtg attcaagtgg gtaatgattt 340741 gtttttctcg gtcagcgggg gttccgcctc gtttgatcca gctatcgtat tgaatcggca 340801 agttccactt ttggatgtct tgataggcca gttgattggc gctgaacatc gcctgccatt 340861 ctgataatga gctttcacga acatgggaag ggtctcgaag ccggttcaaa tgattgacaa 340921 actcatcaag aacgggatct tcaggcgcgt aatgatcaac taagagaaaa cgtccgtcct 340981 gttttagtac gcgtgcaacc tctctgacag ctttgcggac atctgaaaaa tggtgggctg 341041 cgtatcggca ggtgatgatg tcaaatgaat cgtcggggaa ggggagtgac tctgccgttc 341101 cttgctgaaa gcgtacgttt tcaactcctt tttcttgcgc gaaggaggac gcaacctcaa 341161 ccatctcttt cgttgcatca acaccgatgc actcctgtac ataaggagaa aatgccagcg 341221 ccgtatggcc ggcgcccgct cctatatcca gcactcgatg ctctgcccgg cattccgctg 341281 ttttgatcat caaccccaaa tcttccccct cggcaaatac cttttcatcc cgatacatct 341341 cggcgttttt agaaaacggt gtttcatttg tcatttgaac cagctccttc ttttcgtaaa 341401 tgatgatatg gattatgtta gcaatttctg ttatgattcg tccaagatat aaaaatgatg 341461 aaaatgatag gttcaaccta tggaggctga aatggatatt aaagtgatgg aatatgcagc 341521 ggaaattgcc cggcgccaaa gctttacaaa ggcggcggaa catcttcata tcgcacagcc 341581 gtctctcagc cagcaaatca aaaagcttga ggctgagctg gggcttaccc tttttcacag 341641 atcccatggc tctgttacac tgacacctca cggcaggcgt ttcattgaaa aagccgagga 341701 catcattcgt tccagagatg atttgcttcg ggaaatgcag gagcgatcac agggaatcgg 341761 tcataaatta tccatcggga ttcctgctgt aacagggaga tatctctttc ctccgctgct 341821 gaagcagttt ttggcgcgct atcctcatgt ggaggttcag cttgttgaaa aagatccggt 341881 ttcattagag aagatgacgg caaagggaga agttgacctt tctgttttat ccttgcccat 341941 cgaggatgaa cggctctcca ttacaccctt gctcacggaa ccggttgttc tcgcggtgcc 342001 gaaggaaaaa caaaggtgga tgccgccgga attggtcgcg ctgattgaga aagcgctgga 342061 agaagatgag ggacgccagc cgtgtgtgcc gattgacatg gtaaggaacg tgccctttat 342121 tctgttaaaa gaaggcttcg gctttcgcag gacagttctc gatctctgtg cggaaagcgg 342181 ctttaagccg aatgctgcct ttaagacgag ccatattgaa accgcccaat ctcttgtggc 342241 taacggatta ggtgtgacaa tggcaccgaa tatggtcaga agggataaag atccgggtgt 342301 gatctattta tcgattcaat ccgcgccatc acgaaccctc gtctttgtct ttttaaagaa 342361 ccgctatgtc agtctgacgg cccaggcctt tatggaacta agccgggaaa gtcttaaaca 342421 aacgtttgat gaaggctgtc tgggaaacaa agatgaaaat atttagaaaa caaagacgaa 342481 acgtggtagt ataggaatac aaactaaatc ttataaaaca aaggggaata atcggaaatg 342541 caactattcg atctgccgct cgaccaattg caaacatata agcctgaaaa aacagcaccg 342601 aaagattttt ctgagttttg gaaattgtct ttggaggaac ttgcaaaagt ccaagcagaa 342661 cctgatttac agccggttga ctatcctgct gacggagtaa aagtgtaccg tctcacatat 342721 aaaagcttcg gaaacgcccg cattaccgga tggtacgcgg tgcctgacaa ggaaggcccg 342781 catccggcga tcgtgaaata tcatggctac aatgcaagct atgatggtga gattcatgaa 342841 atggtaaact gggcactcca tggctacgcc acattcggca tgcttgtccg cggccagcag 342901 agcagcgagg atacgagtat ttcaccgcac ggtcacgctt tgggctggat gacgaaagga 342961 attcttgata aagatacata ctattaccgc ggtgtttatt tggacgccgt ccgcgcgctt 343021 gaggtcatca gcagcttcga cgaggttgac gaaacaagga tcggtgtgac aggaggaagc 343081 caaggcggag gtttaaccat tgccgcagca gcgctgtcag acattccaaa agccgcggtt 343141 gccgattatc cttatttaag caacttcgaa cgggccattg atgtggcgct tgaacagccg 343201 taccttgaaa tcaattcctt cttcagaaga aatggcagcc cggaaacaga agtgcaggcg 343261 atgaagacac tttcatattt cgatattatg aatctcgctg accgagtgaa ggtgcctgtc 343321 ctgatgtcaa tcggcctgat tgacaaggtc acgccgccgt ccaccgtgtt tgccgcctac 343381 aatcatttgg aaacaaagaa agagctgaag gtgtaccgct acttcggaca tgagtatatc 343441 cctgcttttc aaactgaaaa acttgctttc tttaagcagc atcttaaagg ctgataaatg 343501 tgaaaagccg ccgcatatca tcaggcggtt tttttctgca aactgccgga atgagaacag 343561 actggagacg aatagatatg aaacaaagaa tcattgatga attaaaacgg atcgagcagt 343621 catacggagt caaaatcgtg tatgccgtcg agtcaggaag ccgcgcatgg ggatttccct 343681 cgcaggatag tgattacgac gtccgcttta tttatgttcc gaaaaaggag tggtactttt 343741 caattgagca ggagcgtgat gtcattgagg aaccgattca cgatttgctg gatatcagcg 343801 gctgggagct gagaaaaacg cttcggcttt tcaaaaagtc aaaccctccg ctactcgaat 343861 ggctgtcctc agacattgtg tattatgaag catttacgac cgcagagcag ttaagaaaac 343921 tccgcacgga ggcatttaag cctgaagcaa gcgtgtatca ctatatcaat atggcgagaa 343981 ggaacgtcaa ggattatcta caaggacaag aggtcaaaat taaaaagtac ttctacgttc 344041 ttcggcctat tttggcctgc caatggattg aaaagcacgg aaccataccg ccaatggact 344101 ttactgtttt gatgaatgaa cttgttgctg aacccgagct gaaggctgaa atggaaacct 344161 tgcttgaacg gaaaagaaga ggggaagagc ttgacctcga agcaagaatc gatgttattc 344221 accaattcat tgaaacggaa atcgaaagaa tcatggaagc ggcaaaagaa ctgaaggcag 344281 agaaaaaaga tatgacatct gaattgaacc gtttgctttt gaatacggtt gaagaagtgt 344341 ggaaggatgg aggaagctga tgttttttgt cgcttccttt tctcctttat tcgacagaat 344401 ccccccccga ctttctaact atctgattgt ggcaaaccca caaaaataat cagaatcttt 344461 gtattttgag aatattgtga acgctggttt tgtccattta caataaactc atacaaatac 344521 ttcttagatt gcggggtgtt gaggttggaa gtgatcacaa gagatttttt cttattttta 344581 tccaaaagcg gctttctcaa taaaatggcg aggaactggg gaagtcgggt agcagcgggt 344641 aaaattatcg gcgggaatga ctttaacagt tcaatcccga ccattcgaca gcttaacagc 344701 caaggcttgt cagttactgt cgatcattta ggcgagtttg tgaacagcgc cgaggtcgca 344761 cgggagcgta cggaagagtg cattcaaacc attgcgacca tcgcggatca ggagctgaac 344821 tcacacgttt ctttaaaaat gacgtcttta ggtttggata tagatatgga tttggtgtat 344881 gaaaatatga caaaaatcct tcagacggcc gagaaacata aaatcatggt caccattgac 344941 atggaggacg aagtcagatg ccagaaaacg cttgatattt tcaaagattt cagaaagaaa 345001 tacgagcatg tgagcacagt gctgcaagcc tatctgtacc ggacggaaaa agacattgac 345061 gatttggatt ctttaaaccc gttccttcgc cttgtaaaag gagcttataa agaatcagaa 345121 aaagtagctt tcccggagaa aagcgatgtc gatgaaaatt acaaaaaaat catccgaaag 345181 cagctcttaa acggtcacta tacagcgatt gccacacatg acgacaaaat gatcgacttt 345241 acaaagcagc ttgccaagga acatggcatt gccaatgaca agtttgaatt tcagatgctg 345301 tacggcatgc ggtcgcaaac ccagctcagc ctcgtaaaag aaggttataa catgagagtc 345361 tacctgccat acggcgagga ttggtacggc tactttatga gacgccttgc agaacgtccg 345421 tcaaacattg catttgcttt caaaggaatg acaaagaagt aaaaaaggag agattatcat 345481 gacaacacct tacaaacacg agccattcac aaatttccaa gatcaaaaca acgtggaagc 345541 gtttaaaaaa gcgcttgcga cagtaagcga atatttagga aaagactatc cgcttgtcat 345601 taacggcgag agagtggaaa cggaagcgaa aatcgtttca atcaacccag ctgataaaga 345661 agaagtcgtc ggccgagtgt caaaagcgtc tcaagagcac gctgagcaag cgattcaagc 345721 ggctgcaaaa gcatttgaag agtggagata cacgtctcct gaagagagag cggctgtcct 345781 gttccgcgct gctgccaaag tccgcagaag aaaacatgaa ttctcagctt tgcttgtgaa 345841 agaagcagga aagccttgga acgaggcgga tgccgatacg gctgaagcga ttgacttcat 345901 ggagtattat gcacgccaaa tgatcgaact ggcaaaaggc aaaccggtca acagccgtga 345961 aggcgagaaa aaccaatatg tatacacgcc gactggagtg acagtcgtta tcccgccttg 346021 gaacttcttg tttgcgatca tggcaggcac aacagtggcg ccgatcgtta ctggaaacac 346081 agtggttctg aaacctgcga gtgctacacc tgttattgca gcaaaatttg ttgaggtgct 346141 tgaagagtcc ggattgccaa aaggcgtagt caactttgtt ccgggaagcg gagcggaagt 346201 aggcgactat cttgttgacc atccgaaaac aagccttatc acatttacgg gatcaagaga 346261 agttggtacg agaattttcg aacgcgcggc gaaggttcag ccgggccagc agcatttaaa 346321 gcgtgtcatc gctgaaatgg gcggtaaaga tacggttgtt gttgatgagg atgcggacat 346381 tgaattagcg gctcaatcga tctttacttc agcattcggc tttgcgggac aaaaatgctc 346441 tgcaggttca cgtgcagtag ttcatgaaaa agtgtatgat caagtattag agcgtgtcat 346501 tgaaattacg gaatcaaaag taacagctaa acctgacagt gcagatgttt atatgggacc 346561 tgtcattgac caaggttctt atgataaaat tatgagctat attgagatcg gaaaacagga 346621 agggcgttta gtaagcggcg gtactggtga tgattcgaaa ggatacttca tcaaaccgac 346681 gatcttcgct gaccttgatc cgaaagcaag actcatgcag gaagaaattt tcggacctgt 346741 cgttgcattt tgtaaagtgt cagactttga tgaagcttta gaagtggcaa acaatactga 346801 atatggtttg acaggcgcgg ttatcacaaa caaccgcaag cacatcgagc gtgcgaaaca 346861 ggaattccat gtcggaaacc tatacttcaa ccgcaactgt acaggtgcta tcgtcggcta 346921 ccatccgttt ggcggcttca aaatgtcggg aacggattca aaagcaggcg ggccggatta 346981 cttggctctg catatgcaag caaaaacaat cagtgaaatg ttctaagcgg gactaaatgg 347041 gcatcctccc tgcgggggtg tccatttcat ccatatacta taaaaaagag gaggaagtgc 347101 catagaaaac acacagctga ttatttcgat ttgtatttat atggcgggaa tgctgctaat 347161 cggctacttt gcttacaagc gtacgtcgaa tctgacggat tatatgctgg gaggacgctc 347221 tttgggtccg gcagtaaccg ctctcagtgc cggcgctgcc gatatgagcg gctggctgct 347281 aatggggctt ccgggcgcca tgttttctac tggtctgagc ggcgcttgga tcgtcatcgg 347341 actttgcctt ggagcgtggg cgaactggct ttacgtcgca ccacggctga gaacctatac 347401 tgaaaaagcg gggaattcta ttacaattcc cggattcctg gaaaatcgct tcggagatca 347461 aacaaagctt ctcagactgt tttcgggaat tgtcatttta gtctttttca cgttttatgt 347521 atcgtccgga atggtgtccg gcggcgtctt attcaacagc atcttgggga tggattatca 347581 caccggcctg tggattgtga cgggtgttgt tgtggcatat accctgtttg gcggcttttt 347641 ggcagtcagc tggacagatt ttgttcaggg gattattatg tttgccgcac tcattcttgt 347701 gccgatcgtt acgtttttcc acacgggagg agcaggtgat acagttgctg aaatccgctc 347761 tgtagatcct gatatgttta atattttcaa aggaacgagc gtccttggca ttatttcttt 347821 gtttgcctgg gggctgggat actttggcca gccgcatatt attgtgcgtt ttatggcgat 347881 aacgtctgtc aaagagatca aaagagcgcg cagaattggg atgggctgga tgattttgtc 347941 tgcagtaggc gcagtgctga ccggtttggg cggaatcgct tattaccatc agcgcggcat 348001 gacactgaag gacccagaga cgatttttat tcaattaggg aatatcttgt tccatccgat 348061 tatcacgggt tttctgattt cagcgatttt ggccgcgatt atgagtacaa tttcttccca 348121 gctgcttgtg acatcaagct ctctggtaga agatttgtat aagtcgatgt tcagacgctc 348181 agcttcagat aaagaactgg tgtttttagg ccgactggct gttctggctg tttcaattgt 348241 cgcgttggtt ctggcttggg agaaaaataa caccatcctt ggattggtca gctacgcgtg 348301 ggcgggcttc ggtgcatcat tcgggccagt tgtactgctc agtctgtttt ggaaacgaat 348361 gaccaaatgg ggggcactcg ccggcatgat tgtgggagca gcgactgtaa tcatttgggc 348421 gaatgccggt ctttcggact ttctgtatga aatgatacct ggttttgctg cgagtctatt 348481 atctgtcttt tttgtcagca tattgacgca ggctccgtca caagctgtca cagaccagtt 348541 caacgactac caagatacaa tgtcgcaata aagatcgaaa ggaggaggaa ggggctgtcc 348601 ctttttcctc ttttctcctt ttaagcggcc atttttttct tttggaaaca aacgtatttt 348661 tttctataca aaaagacccc gtatggatat gattaaagta aaaaaagtat aggagaaaaa 348721 ggtatggaag agcttttaga gagagttttt tcattttcag atgttgataa gctaattgat 348781 tttattagct atgaactgca aaagccagtg atactggaaa gcgcggattt ctttttgtta 348841 gcctataatt cttactatat taaccatttt gattctgcca accagcagac tattttttcg 348901 aaaaagtgtc cggtccagat ttttgagagg tttctgaagg acggaattat tgaaaaattg 348961 aaaacagagc ctgagccttt tcgcgtcaat aaaattgaaa gcattgggtt aaaccagagg 349021 gtggtcgtga gtgcaaagca caaaggggaa gtcatgggct acatctggat tcaggagctg 349081 gaccaaaatc tgacggatga agagctcgac tttttgtacg agacctcctt ccatgtcggg 349141 aaaatcattt ataaaacgaa taaattgaaa caggaaaagg aagaaaaagc agaggatctc 349201 atcaaacggg cgatctatca gcaatttacc tctgagaagg aactcagacg ggaagctgaa 349261 aggatcaaca ccgtgctgcc ttccatgttt tcagttgtta tcctgcacgc cgcaaatggg 349321 gatggggaag cggttgagga tttaaaggaa aatatcaggt cgtacctgaa tttacgggat 349381 aaggtcagtc atgtcttaac gatcgaatca aacattgtca tcgtcgtagc gagtttttcc 349441 caaaaaagct ccgtctcctc agcagcttct gagtttatta acaagctgtt aacacatttt 349501 cactttcaaa aaatacctac ccctatttat atcggtatcg gaaacgaata taatcaccta 349561 ttaaaacttg gcaagagcta cacagaagca cttgaagtca tcaaagccgc agaaatcacc 349621 ggcaatcagg aaaacattcc atatgaatat gccaaactcg gcatttaccg ctatttagaa 349681 agcatcgaac agaaaaatga atttttagaa tacgagaata aagatttagc tttattaaaa 349741 gcaaaagacg aagaaagcag cactgagctg ctcaaaacct tggaaatcta tctcctcaac 349801 aactgcaaaa caaaaccagc ggcagaacag ctgtttattc accaaaatac attgaattac 349861 cgcatcaaac agattactga gatgacgtcg atcgatttaa gcgatttcag aacgcggtgc 349921 cagctctatc tcgatttgat gctgatgaaa aagaaataaa aaagaaacca gtacttgtac 349981 tggtttcgtc ttcacttaaa atcctctgta aacatacgga tcatcaggtt ttttaatggt 350041 attccagtca gttactttga cgacagggag agttgacttg aatggctggt aatattctga 350101 ggccagagtg cccttaatgt gaatccattc atcatccttg atgtccatgt ccttcggaaa 350161 ttccacaagc atcccgtaca cgccggaatc agcgatacag tgaatgatgc caaaccttaa 350221 tacgaacagc tgatttttgt taattgcgtt tcctttgtaa gcaaatccat gaaattctat 350281 cgtccgtccg agaaattcac ccggatagtt atagatggtt tccattcctt ttaggaaatc 350341 gtcatcggtc agagaaatct cttttttgct ggaatactta ttaaacagct gtttcatttg 350401 tttgtcatag ctgtcttgcg cgtaataaag gctggcatca ggccgcaaat actgtgtttg 350461 ggagtagtga tctccgctct ccatcgcctt aaacgagaac ccttttgttt tgactatgga 350521 tgagtcaagc gttgcaatcg ggaagaagat gcctgacacc aaaggaaaaa gaaaaacaac 350581 ataaatcaaa taacgctgat aaaatggctt gttttgttca tggtcatgct cgtgatcatg 350641 gccgcacccg caatcatggt catggtgatg tccgcttttt tcaggcgact tgataaatag 350701 atatgcttgg acggcggtca gaatggccag caggaagatc gcaataaagg aaagataggc 350761 atatttcata ttgatatatt ttgttagatt tcctgaggca tgcagatgat aaaagaaaaa 350821 cgtaaatccc atcagcacca ataaacgaaa catccaatca cccctttacc agtagtgatc 350881 ccgctaaaac aatcacgaca atgtatgtaa tcagcaggaa aacaaatcgt tttttgaagg 350941 ccgcaagcat catcaataga ttcttaatat ccaccattgc accaaagacg agaaaggcga 351001 ttaacgatcc taatgaaaac gtgctgctga aggaagacgc gatgaacgca tcaacttctg 351061 aacaaagcga caggacaaac gccagaccca tcatcacgag ggaagaggat acatcattct 351121 gcccgatcgc aagcagagtg gatgttttga catacgtctg catagcggct gcgataaagg 351181 cgccgatgat taaatatttc cccacggaga aaaattcatc aatggcatgc cgcaaggtcc 351241 cgcccagttt ttggagcaag gtgccgtgat gatgatggtg gtgcccgggt tcatcaggct 351301 ttaaaagctg gttatcctta aattgatagg ataagatgac cccgatgatc agcgaaacgg 351361 cgagagccag tccgcctctg taaaagacca cgctccatct attcccgaac gcaatataag 351421 tagaaaataa aacgatagga ttaatgatag gcgcggtcag catgaaagca acgcccgcat 351481 gcagaggaac tccctttaac agaagccgcc tcgtaatcgg gatgatgccg cattcgcagg 351541 cgggaaataa aacgccggcc agcgcaccga ataaaacggc gagaaaacgg tttttcggca 351601 tgattcttgc aatcatttct tcagaaacaa acatttgaat gattccggaa agtatgacgc 351661 caatcagaat aaacggaatg gcttctatta aaatgctgat aaaaatagaa ttcagctgaa 351721 gaaaagatga ttgtgctgtc acaataaaac ctccgctcat gttaagctgc ctttcttatg 351781 ataccagaaa aaaaggcact gcttgtttga cggaggaggg gaaaggatcg tttcactttg 351841 gttaggattc caaaaagccg agtaggatac tgcctgtttc tgcagcttct tttccgagcc 351901 aaatcaggtg tccccatgag tgaagcaaac agagaacagc gccacgaatg tgctcttttg 351961 catgatgtgc atgtgacaag tcaaccaatc cgtcataaac actttgcata atcagcacgg 352021 gacatatgat ggcttgcagg tcttttaaag agacagcggc ggtttgtgac aagtcaatca 352081 gaaatccttc acccgagcgc tgccggctgt tcattttccg aaatgcttct atgtcttttt 352141 cattcatcaa ggacttgatt cgctgaaacg gaagcgtgct gaattggggg ctcatagctc 352201 gaaacatcaa acgcgggaaa gcgttattca aggaagaaat cagcttccat atccactttt 352261 ccaccggcgg gcggaagaga atttccccca atttatattc agtgtctttt ggggtgagcc 352321 actctttggt gactgcggat tgcagggtca atgtatttac tctttccgga taatgtgagg 352381 caaagcatat gccgctcggc cctcctgctg agatggcgat cacatggaca ctctcgattt 352441 gtagatgatc taataatttc acatagaaac ggcaggcatt ggcaagactt tttccaattt 352501 cttttgacgt ccgtccatag ccaggccttg aaggcgtaat gatggaatac ccttgttcaa 352561 tcaacgctgt gtatccgaat tcctcgtaac aatttgaatg cccgccatgc atgacaagga 352621 tcggagttcc cttgcctgtc acagaatatt ctagtgtacc gccatcgaag gtgatcgttt 352681 caactcgtct tttcatctgt ttcacccaat tggtttttgc ctattataga gttttcagca 352741 attgaccaca aggtagaaga aatgaataaa caaaggccct tgaaatatga tatactttgt 352801 attgatattc attctcaatt aaaactttga tatagatgtg aacgggaggc aggacggatg 352861 gctgagaatc aagaggtata tgacgttacg attataggcg gggggccgat cgggctgttt 352921 actgcttttt actgcgggat gcgggagctg aaaacaaagg taatcgaatt tttgccgaag 352981 ctcggaggga aggtgtcttt attctttcct gagaaaatca ttcgcgatat cggcggcata 353041 ccggggattg cgggaaagca gctgatcgag cagctgaagg agcaggcggc aacgtttgat 353101 cctgatatcg tattgaatca gcgtgtgacc gggtttgaac gcctagatga cggcaccatt 353161 gttctgacgg gttctgaagg gaaaaagcac tatacaagaa ctgtgatttt ggcttgcggc 353221 atgggtacac ttgaggtcaa tgagtttgac agcgaggatg cggcccgata tgcgggcaaa 353281 aatcttcatt atggagtgga gaagctcgat gcgtttaaag ggaaacgcgt ggtgatatca 353341 ggcggcggag atactgcggt cgattgggct aatgagcttg aaccgattgc ggcgtctgtg 353401 actgtcgttc atcggcgtga ggaattcggc ggaatggaaa gcagcgtgac gaaaatgaag 353461 caatcatcgg tgcgggtgct tacgccttat cggctggagc agttgaacgg agatgaagag 353521 ggcatcaaaa gcgtgaccgt ttgtcatact gagtctggcc agaggaaaga catagaaatt 353581 gatgagctga tcattaatca tgggttcaaa attgatctcg ggccgatgat ggagtggggg 353641 ctggagattg aagaaggaag ggtgaaagct gacagacata tgcgaacgaa tcttccgggc 353701 gtgtttgtgg cgggcgacgc ggctttttat gaaagcaagc tgagattgat tgccggcgga 353761 tttacggaag gcccgacagc ggtcaacagt gccaaggctt atctggaccc taaggccgag 353821 aatatggcga tgtattccac ccatcataaa aaattggtgc ataaataaaa cagcccttga 353881 ggaaaagggc tgcttgccat caggtgtgaa ggagtttttt ctctgcatgt tgattgtgga 353941 tgaaagctag caattcatcc tgttcttgta cggctgtgaa tccataaatg ccggcagctg 354001 agtcatcgcc tatgcagacg ataggagggc ggcttgctga cggttccggc aaaatgccaa 354061 tttgttcgcc accattgatc aattgctgaa cggacagctt gtttgggcaa atgaccatgt 354121 gcagcgggga ttcactgatg gtacgctgaa tcatgtgggt gaaccggtca tctatgacgt 354181 tttcatgagt gatataaaac gaacaggatt catgcttttg catgttttcc actgcatggc 354241 ggctcccgac aacaagacgt ttctctgaat caggctgaat ggcggtgaca agaaagcccc 354301 gtttctcaag ctctgtcttt gcttgctcag atgctgcact cagtttggct gtcagctggc 354361 ggatgtcgat tttctgagaa gccagtgctc tgaaaaattc acaaaccgcc cggcgcgatg 354421 tgaaaaaaac gtcttcaaag gtgccaatct ttcgaagaat ttcttcattg acaggcatgt 354481 tttcggtccg ccatttcggc cactcgatga gatcggcgcc ggaatcgcgc agcttgtctg 354541 caagcgggtc ttcatcttcg ccatgagtca caaccatcaa atgccgtccg atgagcggtt 354601 tgctttcaaa ccagctgtgt gtttgaaagt tgacgatgtc tccgatgacg ataatcgcag 354661 ggtttgtaat ctggtgttcc tgcacttttt gctgaatgtt ctcaagtgtt cctttcacac 354721 tccgctggcg gccccacgtt ccccattgga tgacaatgac agggacagaa ggcgatttcc 354781 cgtatgaaat aagctgctgg caaatataag acaagttctt gacacccatg taaaaaacaa 354841 gggtttgaac gcttcgggcc agcccttccc agtcaaggtt cggcgtgcct tttaatgatt 354901 tatcatgcgc tgtaatcatg gcaaaagacg atgcaaaatc ccgatgcgtg acggggatgc 354961 ccgcatatag cggcgctgca attccagagg tgattcccgg caccatttca tagcgaatgc 355021 cgtgctcatg aagagcatct gcttcctcgc cgactctgcc gaatacgctc ggatctccgc 355081 ccttcaagcg aacgacggtt aacccattta atgctttttc aaccagcagg gcgttaattt 355141 ctttttgttt cataaaatgg cggtttggca gttttccgca ataaataaac tggcagtccg 355201 gtgatgcaaa ttcgagcagc ttcgggttgg cgagccggtc atataaaatc acatctgctt 355261 ccttgagcgc ctgttttcct ttgatggtga gcaggcctgg gtcgccgggt ccggctccca 355321 cgaaatatac gattccgttc ttcatgatca tgtcatcctt ccgtcactgt aaaaaatgaa 355381 ggaccactag aaaagtgatc cggtcttttg atcaatatac gagataaaca tgttctcctt 355441 cgatcagcgt ttcatatgtt ttgacgcatc cgtggtcagg ttcttggacg attccgtctt 355501 ctaaggaaat tttccagtcg tgcatcgggc agaaaacata ttgaccgctg acgatgcctt 355561 ctgccaggac gccgccctta tgcggacagc ggttttcaat ggcgcggatg cttccgtctg 355621 aaagcttgaa aaccgcgagc tccttatctt caatatacac tgttttgcct aattgttcag 355681 gcaattcttc aatttttccg atacatactt ttgttacgtc tttgtttacc atgtccattc 355741 ctcctcaatg atagtttttg tcattatgat gtggtcacga cattttcaaa taattcttta 355801 gaggtttgtt tatcctctaa aaagtctttc cacggatcct tgtggacaga gagtgtttca 355861 ttcattcggc cgttcagctc ctgccgcttt tccggatcgt ttaacacgga ttggacatgg 355921 gataaaccga cgcgctcaag ccatgcggac gtacgctcca gatagtttgc ggtttccctg 355981 taatattgca ggtaagcgcc cgcgtattct aagacttctt catttgtttt caccttcatc 356041 agcaaatcgc cggcacgcaa atgggttccg ccgtttccgc cgacataaag ctcccagcct 356101 ccgtcgatgc cgacaacgcc aaggtcctta atgccggatt ccgcacagtt tcgcgggcag 356161 gcagacacgg ccattttgac tttgtgaggc gtgttcagcc cttcgaattt tttctcaagc 356221 gcaatgccca gtgccatgga gtcttgtgtg ccgaagcggc agaattgctc gcctacacat 356281 gttttcactg tgcggagcgt ttttccgtac gcgtagcccg atggcatatc aagatcttcc 356341 cataccttcg gaaggtcttc ttttttcacg ccgataagat caattcgctg gccgcctgtc 356401 attttcacga gcgggatctc atatttgtca acgacatcgg cgatcttgcg caaatctgtg 356461 gagttggtca cgccgccgta catccgagga acgactgagt atgttccgtc tttttgaata 356521 ttggcgtgca ttcgttcatt aacaaagcgg gatgtccggt catcctcgta tttggttgga 356581 ttgatcatgc ctaagtagta gttcagagcg ggtcggcatt tagaacagcc ttctggcgtt 356641 ttccagccga gcacattcat gacttctctt gtatgtgaca gccctttggc tttgatttct 356701 tctacgactt catctctcga caatgtggtg cagccgcaaa tggcttcttt ttgcgctgac 356761 gcatcaaagt ctgatccgag cgtatgctgg aggatttctt ctacgagcgg cttacagcct 356821 ccgcatgagc gggatgcgcc ggtgcatgct ttgatttcgt ccgttgacga gcagcccttt 356881 tcctgtatgg cttgaataat cgcacctttt gacacgccgt tacagccgca gatgatttca 356941 tcgtcgctca tcgctgcggt tatgcttgtg cctgcttcct ggctgagggg ctgtaagatt 357001 gatattttag aggtttcaga gatatcggct tctttttgaa tcatagaaaa caggcgattg 357061 ccttcgctgc tgtcgccgaa taaaacagca ccgacaattt gattgcctct caggacaatt 357121 tttttataga tgccgtcctg ctcatcgaag actttaatcg cttttttctc ctctgattcg 357181 ttaaagtcac cggcagagaa gacctcgacg cctgatacct ttaactgtgt ggagagaacg 357241 gagccctcat acggttttgt ttcgatgccg cacatatgct ttgccagcac ttttgcctgt 357301 tcatacagcg gcgccacaag cccgtaggcg attcctcggt gctcggcaca ttcgccgacc 357361 gcgtaaatgt gcgggatttc agtctgcata taatcgttga cgatgatgcc gcggttaacc 357421 ggaatgccgc tctcggcccc gagcgttgta tttgggcgga tgccgacagc catgacgact 357481 aaatcagctt caatgcttgt gccatccttg aatcggaggc cttcgacacg gtcgtcaccg 357541 acaatttctt ctgtttgctt ttcaagtaaa aaggtcatac cttgtttttc taactcgttt 357601 tgcagcaggc gtcctgccgt tgcatcaagc tggcgctcca tcaggaatgg ggcaaggtgg 357661 atgacggaca cgtccatgcc gagattcagc agtccgcgag ctgcttccaa accaagtagt 357721 cctccgccga tgacggcagc ttttttatat tgttttgacg cggcgagcat tgtgtctgta 357781 tcttttatgt cccggaaagc tgtgacgcct tttttgtctg cgcccggaat cggaaggata 357841 aaagggaccg atcctgtcgc caggatcaat tcatcgtaag gctggattct gtctgcatct 357901 gtgatgactg ttttgttttc cgtgtccact ttgatgactg tttcatttgt atacaattga 357961 atgttgtttt cttcgtacca gtcccaatcg tttaacgtaa tatctttaat atctgtatcg 358021 ccttgaagca cttttgacaa aaggattcgg ttgtaattgg gatgcggttc ggcaccgaaa 358081 attgtgatct gaaactcgtc tttagcaaca ctcagtatct cttcaatggc ccttaccccg 358141 gccattccat taccaacaag aactagctgt ttttttccca tcagatgatc cgctccttat 358201 caaatgtttt ttccagcgta gcacagcaaa aaggaatatt taagatacat gttataaaat 358261 gtaacaaaat atacgaaaag ttctaaaaat tttatgaaaa atttaaatag gtatgattcg 358321 gacggcgcat accttaaaac cgggcatttt acaggctgga tctaaggctt ccccgattaa 358381 atcattcaca ttttgagcgt ctgcccaatg gatgggaaca aaaacggtat cttttctgat 358441 ttgttctgat aatttgctgc ggacggtgat gcttccccgc ggcgattcta tttttaccag 358501 tacacggtcc tcgatattgt aggtcgctgc tgtttgcgga tggatctcca taaacgattc 358561 aaaatgtctc gcggcaaggg cggcgctttt tcttgtttgg acgcctgtta agtagtgaga 358621 catgactctg cctgtcgtta aataaagcgg ataatcggct gtcggcttct cttttggaac 358681 aggtggttcg tttggaatca cacttaatgc cgctttttga tccggatgag caaatgattc 358741 tgtaaacaag cgcccagttc cgggatgatc agattccgga cacggccaat gaatgccgcc 358801 ttcacgtctg agcctgccgt atgagatgcc tgaataatcg gcaatcccgc ctcggctcgc 358861 ttctctcaat tcattgaaaa tatcctccgc tgacgtataa gaaaagtagc ggcccttgcc 358921 gagagcggat gcgagatcac aaatgatctg ccaatcatgc tttgcttcgc cggggcatgg 358981 ccggcttgct tctcttaatg tcacgcgtcc ttctacattt gtcatggtgc cttcatcttc 359041 taagtaagag gaggcaggta aaatcacatc tgcgtatttc gcagtctcag aaataaacaa 359101 atcgattgcg acaaagaatg tcagtcttct taaagccttt ttcacgagat ttgcatttgg 359161 actggaaaca gcagggttgg agcacatgag gaacagtcct ttgatgtcgc cgtcattgat 359221 tttttccatc atttcatagg ctgagacacc ttttcgcggg agttcatcct gatggattcc 359281 ccacactttc gcaatatgcg cccggtgttc ttcgttttcg atagaacggt agcctggaag 359341 ctgatcggct ttttggccat gctctctggc gccttgcccg ttgccttgtc cggtgatcgc 359401 cccgtagccc gagtaaggtt tgccgatttt tcctgtgatc agcaccatgt ttaagaagcc 359461 tttcacagcc gctgttccat cggtttgctg ttcaatcccg cgggctgtaa acagcatgcc 359521 ggacgtttcc ttggcaaact tcacagcagc ttttcttata tccaccagcg agacactcgt 359581 ctgttcggcg atgtcattca ggtccaacga gtcagtatgc tgcttcagct cttcgaatcc 359641 atttgttcgt gattgaatga aatcctcgtt tataagctgt tcgtcaatga tgattttgac 359701 gagaccgttg gcaagggcgg cgtctgtgcc gggtttgatt ttcagatgaa gatcggcgat 359761 tttcgttgtc gctgtttcac gaggatcaat ggcaatgaag taagctccgt tttctttcgc 359821 tttttcaaaa tacggcataa tcgtaggctg gcattccgca atattggtgc cggccagaat 359881 gatcacacgg gtgtggggga tgtctgataa aggattcgtt aagcctctgt ccgcgccgaa 359941 tgtttggttg gctgcggtgg ctgctgcgga catacaaagt ctcccgttgt agtcgatgta 360001 ttttgtctgt aagcctactc gtgcgaactt ccctaacaaa tacgcctctt catttgtaat 360061 cgaggcgctt ccgtataccg ccatggcgtc atgtccgtgt tcagtttgga tcattgtcac 360121 ttggtctttg atatgattca gtgcttcttc ccaggaaaca ggcataaact cgccgttttt 360181 cttcagcagc ggccgggtga tgcgggagga gttcaaggca tgctggtgag cattcatgcc 360241 cttgatgcat agccgaccct gtgtcgtagg attatcaatc ccgatcgcag tgtacttttt 360301 gcgcgtgacg atggtttgtt ccacgagctg cattttgcac tgcatgctgc aaaacgggca 360361 ttgagtgtca tatgtttttt ctgattggac gtcttgctgt ttatcacgga aatatctaag 360421 cagtcgttca gtcaaaatgc ctcatccttt cttatatgcg cccgtctcta cagtcgggtt 360481 ttgaatcagt gacagatctg tttggaggct ttccagcagc tgtgccctta ggtcttcttc 360541 gaatagcact tctctgatat gaacgatccc gagacggtct atccactgat gaacaccttc 360601 taagtaatga gccgtttccc gataatactg gatcagtcct ttgatcatgc cggcagtgct 360661 gtcttcgttc tcagtcacgc aaaacaaagc tcctgaacgg gcatgagttc cccggacgcc 360721 gccgatgtga atgtcccagc cagcttgtgt ccgaattgcg ccgacatctt gcagggcggc 360781 ctcggtgcag tctgtttcac atgataagct gatagaaatg ggagcgggta agggaagcat 360841 ctcaagttgt ctttcgattt gggctgccag ctgctgaatc gatcgatttt gcccgcatgt 360901 acatgctttg atgctttgca gcgcgtgtcg gtgttcatta gtgtaaacgg gcattttcag 360961 gtcttttttc atgttcggga gatccgcagg cttgatcccg gaaagcttca gcctttggcc 361021 gtgagtgatg gatacgtcgg gaatgctgta tgcctcaatg atgttggcga tggttcttag 361081 ctgctccgcg tttgtccgcc cgccgtacat ttgcggaatc aggatgcatg tctcttcagt 361141 ggctggctca ggctggacaa acccagggta cagcatttcc agatagtatt gaatcgcagg 361201 aacacaagta ctgcatccgt tttttgtttt ccagtcaagc tggttcatca cttctgccgg 361261 attagtgaat ggcctgcgct gaagctcagc gatgatgtcg tcttctgtaa aatcagtaca 361321 gctgcaaaac gaaggtgtgc tggcgggctt cgtatattcg ctgttggtca tgtatctcaa 361381 aaggtcttca acgagcggtt tgcatcctcc gcaggaccca gtggctttgg tgcagtgctt 361441 gacttcctca acagttgtta agctattcgt gtgcaccgcg tcttcaatcg cgcctttcgt 361501 cactgtgttg cattggcaaa tcgtttcact ggaaggcatg gattcaaata aagggccgct 361561 tgtctccggt tcgatgatct gttttttggc aatggagatg tctcgttgtt taagcaggct 361621 gtcgagaagc cgctgcttgt cacgggtgtc tccgaataaa ataacgccgg ccagtttgtc 361681 atctacaaaa agcgcttttt tataaacgcc tgcttgttcg tcgtagattt tgatgctcgt 361741 cgtgcgttca tcctcttgga tctttcctgc tgaccacaca tcgattccag ctatttttaa 361801 cgccgcagat ggtgctgagc cttgatattc ctcacatgga acgccgcaaa tatgactggc 361861 gagcgctttt ccctgctcat aaagcggagc caccaatccg tacaccgttc cgttatgctc 361921 agcgcattca ccaacggcgt agatattcgg ttcgcttgtc tgcatgaagt cattcacgat 361981 gatcccgcgg ttcactttga ttccagcgga tacagccaat tcaatattcg gtttgacgcc 362041 ggccgccatc acaatcaagt ctgcttttaa tgaagagcca tctttaaaat ggattcggtc 362101 tgccttcgtg gcgccggaaa tggagacggt gtctttctcc aaaagaaagg ttaggccttt 362161 ttgttccagc tctgtttgca gcagccgcgc cgctgtttga tcgagctgtt tttgcataat 362221 gccggcggag tggtgaatga cgctgacatc cataccgaga tgctgtaaac ctactgcagc 362281 ttccagtcct aataagccgg ctccgattac cgcagccttt tgaaagtgct gggccatgtt 362341 catcagcgct tggcagtctt ctattgtccg aaatccatag acaccttttt tgtctgcccc 362401 ggggataggg agaatatgag gggaggagcc tgttgccact attaatttgt catacgacag 362461 agtgcgtttc cgatctgtga tgacctgctg ctgatctgta tcaatctgaa taaccgtttc 362521 gcctgtgtaa agcgtgatcc cgtgcttgtc gtaccaatcc ttgctgttca gtgtaatatc 362581 atcgagtgac gcttcaccct gcaatacaga ggataagaga atgcgattgt aattgggatg 362641 cggctcgctt ccgaaaatga caatctcaaa catgtggcga ttcagcttta atacttcttc 362701 aatacagcgg attccggcca tgccgtttcc cgctaacact aatctttgtt tcttcatgta 362761 tcagacctcc tttggcgaag ctcgtaagtt ttctcctatt aaaaattatg tcacaatgca 362821 ttgttaacgc attaaacgtg tcacaaaaac ttacacatgt cttttccaga aaataatggt 362881 cctatatcct tgattcagaa aatgtaaaat aatgagggtc tagaaagggg aatcttatga 362941 agctgtcgga actgaaaact agcggtcatc cactcacttt gctctgttcc tttttatact 363001 ttgatgtcag ttttatgata tgggttatgc ttggggcgct gggtgtttat atttctcagg 363061 attttggcct gtctcctttt gagaaagggc ttgtcgtagc tgtgccgatt ttatctggat 363121 ctgtgtttcg tatcattctt ggtattttaa cggacagaat cggaccgaaa aaaacggcag 363181 tgatcgggat gctggtgacg atgattccgc tgctttgggg gacattcggc ggccgttccc 363241 tgactgagct gtatgccatc gggattctgc ttggcgtggc gggagcaagc tttgctgtag 363301 cgctgcctat ggccagccgc tggtatccgc ctcatttgca gggacttgcg atggggattg 363361 ccggagcggg gaacagcggc acgttgtttg caaccctgtt tggccctcgt ctggcagagc 363421 agttcggctg gcacattgtc atgggaattg cgctaattcc attattgatc gtctttattc 363481 tttttgtatc catggcaaag gattcccctg cacagccgtc tccccagccg ctcaaaagct 363541 atctgcatgt gtttgggcaa aaggaaacat ggtttttctg cctgctgtac agcgtcacat 363601 ttggcggatt tgtcgggctc tcaagctttt tatctatttt ctttgttgat caataccagc 363661 tgtcaaaaat tcacgcaggg gacttcgtta cattatgtgt ggcggcgggg agctttttcc 363721 ggcctgtcgg gggcttgatt tcagatcgtg tcggcggcac gaaagttctt tctgtattgt 363781 ttgtcatcgt ggcactgtgt atggccggag tcagtagcct gccatctctc tcaatggtta 363841 ttgttctatt gtttgtcgga atgatggggc tcggaatggg aaacggcgca gtattccagc 363901 tcgtgccgca gcgcttccgc aaagaaatcg gcatggtgac gggaatcgtc ggtgcggccg 363961 gaggaatcgg agggtttttc ttgccgaaca tcttaggatc tctcaaacag atgacaggca 364021 catatgctat cggttttatc acgttttcct gtatcgcgct gctggcgttt gcacttgtgc 364081 ttgccgcagg ctattactgg cggaaaagct ggagcgcgga aagcagcccg gcggatgttt 364141 aggattttga cggacacgcg tttgtgcgtg tcttttttat tttctcttga ttttcaacag 364201 tgaaccgatc aaaataaata gtaattatta cgatttgtta gtgagaggag ttttctgaat 364261 gaatcaacat acgctgctcc cgaaaaaaac ggagcgtctt caatactttg gatcggtcag 364321 tccgatcaaa ggcgagaaac cagtggaaaa agagaaaatg aaggacctgc aaaatatcag 364381 gaaggattat ttttttgaca ttcagcatgt aggtgtagct aatgtgtccc atccagtcac 364441 aatcacttct gccatgatgc ctgccgagca aacaacggct gcgaacttta caatgacttg 364501 taatttgccg agaaatcaga aggggattaa catgagccgg ttaacagagc tgctgcaagt 364561 ctatcatcaa aatggctgga ttctctcatt ttcctctctt cagcaattta cgaaagagct 364621 tgcagaaaac atggacacat catctgccac agttgaagtg aggtttccgt ggtttttcga 364681 acggaaaagc ccgaagcttg agaaagcggg tttgatgcat gctgatatat tcatgtctgt 364741 cacctatcgc aaagatcagc cgtttaaaca gcgtgccggc atctcagcaa aagtaacgac 364801 tctgtgccct tgctccaagg aaatcagcga atacagtgcc cataatcaga ggggaacggt 364861 cagcatttgg gcggatattc acccggccgc atcgctgcca agtgatgtta aagctgattt 364921 gcttcacgcc gcagaatcaa atgcttctgc gagactgcat ccggtattga agcggcctga 364981 tgaaaaagcc gtgacagaaa cggcctatga aaacccgaga tttgttgagg atctcgcccg 365041 gctgattgct gcagatttgt ttgagcttga atgggtgtca gcctttgaga ttgaatgccg 365101 aaatgaagaa tcgatccatc ttcacgatgc ctatgcgaag ctgtgttttt cgaaggaagt 365161 ggataaaata tgaaactctc attattcatt attgcagttc ttatgccagt catcctgctg 365221 tcagcctgct ccgatcatgc agaagaacac gcaagtatca atacaaagaa aacggtcgaa 365281 aacataacgg acgttcgaaa aacagcaaaa acaagcattg attggacaaa gccttcgggc 365341 ggagaatacc cggatattaa acagaagcat gtctggattg atgtgaatgt gaaggagcag 365401 aaggcttaca tcaaggaagg aagcaacacc atctatacaa tgatgatttc ttctggtctt 365461 gatcaaacaa aagatgatgc tacgccaaag ggcacctttt atgtagagcc tgaacgggga 365521 gaatggtttt tctccgaagg ataccaggaa ggcgcagaat actgggtatc atggaaaaat 365581 cacggtgaat ttttatttca tagtgtgcca atgactaagg atcaaaaagt catcaaaacg 365641 gaagcagaaa aactaggaac gaaagcatct cacggatgta tcaggctgac cattccagat 365701 gcgaaatggg tatatgaaaa tatccctgaa catacaaaag tggtgatcag ctgaattgaa 365761 aaccgttgac aaaaaggaaa aaagaccata caatttaaat cgtaacaatt acgttttatg 365821 ataaatggct tatcattgtc tgtgcatctg tgaaaagcgg aaaggcatcg attaaggatc 365881 ttgctgtcgg caaaggcaag gatttgcgat ggggaaaagg attaaacgcg gttggagtct 365941 ttactgattt agaaatcggg cggcagcgag aaatgagcgc gaaaagctgc tctacaccat 366001 tgtacatacg gcgaagtatt caatttaaat cgtaatcatt ctattttaat ggaggcacta 366061 ttatgaaaaa aattccggtt accgtactga gcggttatct cggtgcggga aaaacaacat 366121 tgctgaacag cattttgcaa aatcgcgaag gcttgaaaat agcggttatc gtaaacgata 366181 tgagcgaggt gaacattgac gcgggcttgg ttaagcagga aggtggcctt tccagaacag 366241 atgaaaagct tgtggaaatg tcaaatggct gcatttgctg cacgcttcgc gaagacttat 366301 taattgaagt tgagaagctg gcaaaagacg gacggtttga ttatatcgtc atcgaatcga 366361 caggaatcag cgaaccgatc ccggtggccc agactttctc ttatatcgat gaagagatgg 366421 gaatcgatct tacaaaattc tgtcagctgg atacgatggt gacggttgtt gatgccaacc 366481 gtttttggca tgattatcag tcaggcgaaa gccttctgga ccgcaaagaa gcattggggg 366541 aaaaggatga aagagaaatc gccgacctct tgatcgatca aattgagttt tgcgatgtac 366601 tgatcttaaa taaatgtgat ttggtcagcg agcaagagct cgaacagctt gaaaacgttc 366661 ttcgtaaact gcagccaaga gccaggttca ttcgttccgt caaaggaaat gtaaaaccgc 366721 aggagatttt gcatacaggg ttatttaact tcgaggaagc gagcggatcg gccggctgga 366781 ttcaagagct gacggcaggc catgcggaac acaccccgga aacagaagaa tacggtatct 366841 cttcatttgt atataagaga cgtttgccgt ttcattctac acgattttac cgttggttgg 366901 atcaaatgcc aaagaacgtg gtacgtgcca aaggaatcgt ctggtgcgca tctcataaca 366961 acctcgcttt gctgatgtcg caagcaggtc cgtcggttac gattgagcct gtatcttatt 367021 gggtggcggc gttgccgaag cttgagcagg agcaagtcaa acagcaggag ccggaaatcc 367081 tggaggagtg ggacccggag ttcggcgacc gcctaacgca gctagttttt atcggaactg 367141 acctggatga agaaacgatc acgaaagagc ttgatcaatg cctgttgact gagtatgaat 367201 ttgattccga ctggtcgctg tttgaggacc cgtttaaatg gaagctgaat caatagaaaa 367261 aaagccgtcc catggggaac ggcttttttt aatgaaacgt ttgtttaaac ataatgagcg 367321 tattttttct caaggatatt ctgaaagacc gcggcaatgg agcagatggc ccaataaatg 367381 agagcggtca gaatatacat ggtcatataa tcaaactctc tgcccccgat gattttcgca 367441 tgctggagca attccggcac tgtaatcatc gcagcgagag aggacgcctt gatcaagtcg 367501 agcaatacat tggcaagcgg aggcagcgca atacgtatcg attgcggcaa aatgatgccc 367561 ctcatcgtct gccaatagga aagacccagc gaggatgcgg cttcccactg tcctttttcg 367621 acggatgaaa tggctgaacg gttaatttcc gcaatgtagg cggcgctgtt taggctaaag 367681 ccgattaaag cagccgtgac agcggaaaat tcaatgccga tataaggaaa cccgaaataa 367741 aggataaaca aaatcaccaa aatcggaacg cctcgcataa atgagatata gagcttcgcc 367801 ggccatctta acaaagcaag tttagacatt ctggcgagtg atatgaacag gccgatcaca 367861 gttcccgcaa acatgcttac aaaagagatg agcagtgtat aaccaatgcc ttttatgaca 367921 taagggaacg attcaatggc cagcttcgtg ttgaaaatat attcccactg aatgctattg 367981 atcatggcgt ccgattacaa atcaacgtcc tgaacgtcgg catcaatttt ttttgataca 368041 tctgctttat tgaagaattg tttcgacagt ttagtcaaag agccatcctt gctcatctct 368101 ttcaatgctt cgttcatctt tttctgaagt gccgcattgc tttttttcat gacaagggcc 368161 tgtttgttcg gcatgtactt gatgtcagga tgaattgtaa tgttgagatc cgggaatgcc 368221 gcgagcgcaa gtgtctgcag gtaatagtcg tttaaaatga cgtcagtgcg tccgttggca 368281 acatctttta aatattgctc attcgtcgca ttatcataaa tcacttcttt ggcgccgtat 368341 tttctcgcga cctccatgta gacggttgta gccgcgccag ccgctttctt cccttttaaa 368401 tccttgagcg ttttaatccc tgataaatcg tcttttcgga caattgccgt gccgtatgaa 368461 tatttatatg gagtggaaaa tgcgaacttc tcctcacggt ccttcgtcac atcgatgtca 368521 ttcgcggctg cgtcaacctg tccgctgttc accgctgtca gcatcccgtc aatgcccatc 368581 tccttgaact caaccttcag ccccaagcgt tttgccgctt cacgaacaac ttcaacctcg 368641 tagcccgtca gcttatcaga gccagagtca gtatcgtgat aagaagtggg atagagcgta 368701 cctgatgtag cgactacgat tttcccttta tccttaatct gctcccagcc tgtatccttg 368761 gaatcggctt catttttgcc ggaacaggct gccaatataa gaaagaaagc cattgtgaaa 368821 ctgaatataa cggctttgga atgcatgaat gatttcacct atagttcccc caatctgtta 368881 atcaactaaa aagatagcat tgaacataag gggttgcaat atgttgatcg cgttttcaaa 368941 aagttcgaat tgtgtataca aaaagcatgg gtgggtgttt aaaagcgtct atgaagggaa 369001 gaggtgatga aaaaaggaat tgtccaagga tgaatgccag acgtaccaag gaaacgcatg 369061 tgaaagtgaa ggatgcagca gacccgtcac tcatctatgc caataccgga agaaatggtc 369121 aagaggcatg aaaccgatct tcagaataaa tttaagtctt gctgatgccc ctaaggcata 369181 tgatatattc gatgagaaag aaaatggaaa catttaaacc ataatgggga gtcaaatgaa 369241 tatttacaaa ccagccggat tttggatcag acttggagct gcattgttag actacattat 369301 agtctccgtg ccgcttttgc tgatctattg gctgattaca ggaaaagacc caaacgacag 369361 catgttcatc agtttggttg ttctgctgta ttctattttg ctgccgatgt tttggcgcgg 369421 ttatcttatc ggaaaaagga tctgcggaat cagaatcgta aaaaaagacg gatcacaggt 369481 cagtctgtta acaatgtttt tacgggttat tgtagccggc ctggtttact gtataacctt 369541 cggactcggc ttgatcgcca gcctgattct gattgccgta cgagaagaca aacggaccct 369601 gcatgattta atcgcgggaa catatgtcac ttatgcgaca ccaggtgaag aggaacttaa 369661 tgctgacgaa gagattagaa agagcgaata atggttcgct ctttttattt ttatgcataa 369721 aaaatacaag gcagcaaaac atatgaaaaa taggattgga ggaataaaat ggatgaaacg 369781 aataaccatc aacattatca caatgttcat tgcagcggct gtcatttctc tgaccggtac 369841 agctgaggcc gctgaaaaac agcagcagtc tcccgcaaat gttacactga cagatcagca 369901 aaagaaagag attgaacaac tggaagcaga gattcttaaa aagcgcaaag acgtgatctc 369961 aaagtatgta caatacggta tcctgcctaa agaaagagga gaacacatca aaaatcactt 370021 ggacaaacac tttgaaatga tgaaacaaaa cggctttgtt ccaaagcacc atcctcatcc 370081 gcataaattt gaaaaaagac attaagattt taagcatcca atgggaattg ggtgcttttg 370141 cgttatttac aggtaggcaa tattagctga gctgttccgc gactaacatc gagttgatat 370201 gaaacgcgtt tcatagccta tgataggttt atcaaataat tcaggagtga taaacactat 370261 gatccaccag catccagaat cttttccgaa acattttttg tggggctctg cttctgcagc 370321 gtaccagatt gaaggcgctt ggaatgaaga tggcaaaggc ccttctgttt gggatgtgtt 370381 tacgaaaata ccgggcaaaa cgtttaaagg aaccaatggc gagattgcgg ttgaccatta 370441 tcaccgattt aaagaagatg tcgctctgat ggctgagatg gggttaaaag catatcgatt 370501 ttccgtcagc tggccacggg tttttccaaa aggaaaagga gagatcaatg aagcaggtct 370561 agcgttttac gatagtctga ttgatgaatt gctttctcat cacatcgagc cggttctgac 370621 tttatatcac tgggatttgc ctcaagcgct tatggacgaa tacggcgggt ttgaatccag 370681 aaacatcata gaggatttta atcactactg tattactctt tataaacgtt ttggagacag 370741 ggtgaaatat tgggttacgt taaacgaaca gaactacaat tttaatcacg gatttattac 370801 agccatgcat ccgcctggag tgaaagacag aaaacgattt tacgaagcaa accatattgc 370861 gtttctggct aatgcaaaag ccatcgaatc atttagagaa tatgtgcctg aaggcaaaat 370921 aggtcctagc tttgcttatt ctccggctta ccctttatca agtcatccag aggatatact 370981 ggcatttgaa aacgccgaag aatttacgaa caattggtgg cttgacatgt attgctgggg 371041 aacctacccg caaattccat tccgctgctt ggaaaaacag ggatgggcgc cgacaattga 371101 agcaggagat atggacctgc tcgccaaagg gaagcctgat tttgtaggtg tcaattatta 371161 tcagacgatc acctatgaac gaaatccgct tgatggtgtg tcagaaggga aaatgaatac 371221 gacaggccaa aagggaacca atcaggagac ggggataccc ggagtgttca aaacgaaaaa 371281 aaatccgcat ctgacaacga gcaactggga ttggacaatt gacccaattg ggctgcgtat 371341 cggtcttcgc cgaattacaa gccgctatca gcttccagtg tttataacag agaacggttt 371401 gggtgaattt gataaagttg aggacggcac tgtacaggat gattatcgaa ttgattattt 371461 gcgttcgcat cttgagcaat gcagacaagc catcagtgac ggtgtcgatt taatcggcta 371521 ttgcagctgg tcgtttactg atctgttaag ctggctgaac ggctaccaaa aaagatacgg 371581 atttgtatat gtcaatcgtg atgaagaaag cacatccgat ttaaaacgct tgaagaaaaa 371641 aagcttttat tggtatcaag atgtcatcaa gacaaacgga gaaagtttat aaagagtccc 371701 tgagagttat tctctcaggg gtttttcatt acacagaaac agcatcaata atataagtgt 371761 cggcgtgcaa atctgacatt tcagccggca cagtccagca tgtcaattga tagtctcctt 371821 taggcagatc aaaggacagt cttttagaca tgatgctttc aatatgaatt ccgttttctg 371881 tgacatgaaa aggaacagtc actttttttt cgtaggagtt tactgtttct gaactgttca 371941 ggcgaaaaag aataaaggcc tttgtatttc gctgtgcctc aaaggaaatg gctccgtctg 372001 ccgcagcata tcctttttca atcgcttcgt cagtccaatc cattacagga ggtgtagaat 372061 ccttttgaaa tacagtaaat tgatgatatg aaatcgaaag ttcttgcggc ttccatgatt 372121 tgatcaatgt gctgttcctc ctctatgtac tgtttactga attgtgaata aaacctttgt 372181 gccgtctggg taatcggtaa gccgatgccc gacccaagag cctgctccgc ggttgtcagc 372241 gggagaaatg tattctacag aagctccctc accgccttct ttgcacatgg ccattggcca 372301 ttcatctctg tcatacccct ttttggaagg tacgtccttt aatgattgct cgcggcgttc 372361 ttcagctccg tctctgtcaa tagtgcacac ctctgagtgc ccctcattta tcgcatcctt 372421 aatatgcttg gcagtttcgg gataccggtc agatgggaag gccattgttt catcatattc 372481 tttcgtttga gacgtttttt gatcagctga gaaaaagtct ccttttatca ggccgacagc 372541 tgcagctgct atgatgacga tgacgagaag tatcgttttt atgatgtccg tcgtgatgtt 372601 cacctcccgc ttttaaaact gacacaagag taatccagaa agcatttggt gtaaaggttt 372661 aaattttatg ttttacgatc agtttattgc agaaatcgta attttagcag atcgaaatat 372721 ttgttttcag caaaatacga ttgccaattt acaataatga tagtaagtca tcagccgttt 372781 tcggcttgat taatcatttt aaattggctt atgataccgg taagctcctc agctaattga 372841 gaaagtgttt cagaagctgc ggtaatctcc tccattgcag caaattgctc ctctgttaat 372901 gcagccgctt gccgggtatt tttagtagat tctttaatgt cggccgtatt ggctgcaaag 372961 gaatcattta tttgatgtgc actggctgaa atgtttgtta cagatgctga taaatcacta 373021 atctcggcgc tgatttcacc tgttgcagct gcaatttcct taaatgcatc tctggtgcgc 373081 tggatcatgg tgactccttc tgcagcttct gttttcacat gctcaacaga tcttgcagac 373141 cggttcatat ccttttgtat ttctatgatc agttttgaaa tctgccccgc agactgttga 373201 gactcttctg ctaatttccg tacttcatca gcaacaacag caaagccttt tccttgttca 373261 ccggctctgg cagcttcaat cgctgcattc agcgcaagca ggtttgtctg atcagcaatt 373321 tgggtgatga ccgataaaat ttgctcaatt tgtttagagc ggccgtctaa ctggtgtatg 373381 atttctccgc ttttctgaat tgactggtga atcgcatcca tttgcgcctg tacatttgca 373441 atttcctttt gtccaatgtc tgcttttgat tgagcgagct gccctttgtc agcgatagcg 373501 gcagtatttg cagaaatatc ccggatgtct gctgaagctt gttttaatga gctttcacta 373561 ttttcaattc gggtgatctg atcttgggct ccatttgcaa tctgctgtac agcttctgtg 373621 attttttctg aagcttgatt tgtttcctct gctccggctg agagctgctg agaggctgac 373681 gcaagctgaa gggctgattg ttgtacggtt tgtatggtat cgttcagctt cattctcatc 373741 ttattataat agacgcttag ttctgaaagc tcgtcaccgg ttttgtctga cacctctatt 373801 gtcatatctc cgtttccggc actttcaaag gcgcttttta aagcgttcag ccgcttgttg 373861 atttttctgg tgaaaaccaa gacaaggatg actgatacca taatgacgat aacaagaacg 373921 atagcgaatt gagtgaaaag tgattgtgta agtgatgcta aaatactttg attagctccg 373981 gtatacagca tgccgatgat gttcccattt tgatctttta acggcatgta tgcagtctga 374041 taagaagaac ctgctacatc tgcttgtccg taaaaacgct ttcctttctt taaaacagcg 374101 gcaataactt cagaagaagc ctgggtgccg acggctcttt cgccattttt catgacattg 374161 gttgcaacac gagtatcgcc ttggaaaatg gtaatggtat cacctgtctt ttcaccaagc 374221 agatcaacaa tatcttcatt tccattgatt tgtgtttgcc ctttatagag cttattgttt 374281 ttcacctgcc agtcgcctga catgacatca tcaatataag tgctgcttaa agcgagatca 374341 cctttcgctt tttcagttgc catttgtttc atgctttctg taatttcctt aagcatcaca 374401 gtgccaactg atgccgaaaa caaaagaatc accacgaaaa cgaggcaaag aattttagtt 374461 cctagcttca tcttaaatcg ttttatcaac ataattcctc cctttacgat ttgcaggtca 374521 tattacttat cgggtttttg ggtttaaagt tttattttag aaaaaataaa accggcctga 374581 tcttcaggcc ggttgtgtga tgctattcaa ggtttgcgtg gtgagtgaac atagtttcag 374641 aatcgagacc ttttttctcc atgagtttta aaatcactgc atcatagaag agcagcaaag 374701 tttgttcaaa taatgatccc attggctgaa tggttttata gcttccgtta gactggtctt 374761 taggggaacc aggcattctg atgatgaggt ccgcttgttt tccgatgctt gattccggat 374821 tgatggttaa agcggcaaca attccgtgta agctttttgc ttttgctgcg gtatgaatca 374881 agctctttgt ctcgcctgat cctgagccga taataactag atctccttcg gcgagcggcg 374941 gagtgagaat ctcacctact atatgggcgt tgaagcccat gtgcatcagt ctcatcgcga 375001 aggattttgc catcaggcca gaccgccccg cacccgcggt gaaaatttgg tgggatgaaa 375061 gaatgtgatc ggcaagctgg tcagcttctt cattagaaat ataagctgct gaattgtgta 375121 actcattgag aatttccgct acgtattcag tcgttttcat cggagttatc cttggacaat 375181 cagctgcttc atttttgaag ctgtttccgc cttatcagct gcgcttgtaa ttccgccccc 375241 gacaatgaca aggtcaggct tttgctggat cacttctggc agtgtatcaa gtttgatgcc 375301 gcccgcgatt gcggtttttg cgttttttac ggtatttttg attgtcgtta attcttcgaa 375361 agagtttttg ccctctgctt gaagatcata gccagtgtgg acgcagatgt agtcaacacc 375421 gagtgcgtca atttctttcg cacgggattc gatatctttc acgttaatca tgtccactaa 375481 gattttcttc ttttgttttt tggcttcttc tactgcgcct ttaatcgttg catcgtctgt 375541 agcccctaaa acggtgatga tgtcagcgcc tgcttccgac gctttcataa tttcgtagcc 375601 tccggcatcc atgattttca ggtctgcaag aaccttcaat tgaggaaatg cttcttttat 375661 ttctttaacg gctcttaggc cttcattgat gacgaccggt gttccgattt caactacgtc 375721 gatgtattgt tctacctctt tgacaagctc aatggcttcc gggatgttga cgaggtctaa 375781 tgcaagctgt aattccattg ttgatccact ccctttttcg aattattgtt cattctatag 375841 gttccttctt ttgttgagaa gtaggcactt tgaagtcaac aagttacttg gaggatactg 375901 tgaggagaga caatcagatt tctttcgctt gattttatga gtgagtataa tgaaaaaaga 375961 gtctgcaaaa aagtaagtaa gtgatgatac gtatctaaca tacaaaaagg ttactaaggg 376021 gggggattct attgagccgg atggacgaca aaaggtttaa ttgtgagaag gaattaacgc 376081 ttgcagtgat tggcggtaaa tggaaaatgc tcattttatg gcatttagga aaagaaggca 376141 caaaacggtt caatgaatta aaaacattga ttcctgatat tacgcagaag atcctcgtga 376201 atcagctgag agagcttgag caggatatga ttgttcacag ggaagtgtat ccagttgtcc 376261 cgccgaaggt tgaatattct ctgaccccgc acggagaaag cctcatgcct attcttgaag 376321 ccatgtatga gtgggggaaa ggctatatgg aattgattga tatcgacaaa aatgtcatga 376381 aagaatcgtt gtaagacgct cttcgcaagg gtgtcttttt ttgccttttt ttcggttttt 376441 gcgcggtaca catagtcatg taaagattgt aaattgcatt cagcaataaa aaaagattga 376501 acgcagcagt ttggtttaaa aatttttatt tttctgtaaa taatgtttag tggaaatgat 376561 tgcggcatcc cgcaaaaaat attgctgtaa ataaactgga atctttcggc atcccgcatg 376621 aaacttttca cccatttttc ggtgataaaa acattttttt catttaaact gaacggtaga 376681 aagataaaaa atattgaaaa caatgaataa atagccaaaa ttggtttctt attagggtgg 376741 ggtcttgcgg tctttatccg cttatgttaa acgccgcaat gctgactgac ggcagcctgc 376801 tttaatagcg gccatctgtt ttttgattgg aagcactgct ttttaagtgt agtactttgg 376861 gctatttcgg ctgttagttc ataagaatta aaagctgata tggataagaa agagaaaatg 376921 cgttgcacat gttcactgct tataaagatt aggggaggta tgacaatatg gaaataactt 376981 tttacccttt aacggatgca caaaaacgaa tttggtacac agaaaaattt tatcctcaca 377041 cgagcatttc aaatcttgcg gggattggta agctggtttc agctgatgcg attgattatg 377101 tgcttgttga gcaggcgatt caagagttta ttcgcagaaa tgacgccatg cgccttcggt 377161 tgcggctaga tgaaaacggg gagcctgttc aatatattag cgagtatcgg cctgttgata 377221 taaaacatac tgacactact gaagatccga atgcgataga gtttatttca caatggagcc 377281 gggaggaaac gaagaaacct ttgccgctat acgattgtga tttgttccgt ttttccttgt 377341 tcaccataaa ggaaaatgaa gtgtggtttt acgcaaatgt tcatcacgtg atttctgatg 377401 gtatctccat gaatattctc gggaatgcga tcatgcacat ttatttagaa ttagccagcg 377461 gctcagagac aaaagaagga atctcgcatt catttatcga tcatgtttta tctgaacagg 377521 aatatgctca atcgaagcgg tttgaaaagg acaaggcgtt ttggaacaaa caatttgaat 377581 cggtgcctga acttgtttcc ttgaaacgga atgcatccgc agggggaagt ttagatgctg 377641 agaggttctc taaagatgtg cctgaagcgc ttcatcagca gattctgtcg ttttgtgagg 377701 cgaataaagt cagtgttctt tcggtatttc aatcgctgct cgccgcctat ttgtacaggg 377761 tcagcggcca gaatgatgtt gtgacgggaa catttatggg caaccggaca aatgcgaaag 377821 agaagcagat gcttggcatg tttgtttcta cggttccgct tcggacaaac attgacggcg 377881 ggcaggcgtt ttcagaattt gtcaaagacc ggatgaagga tctgatgaag acacttcgcc 377941 accaaaagta tccgtataat ctcctaatca acgatttgcg tgaaacaaag agctctctga 378001 ccaagctgtt cacggtttct cttgaatatc aagtgatgca gtggcagaaa gaagaggatc 378061 ttgccttttt gactgagccg attttcagcg gcagcggatt aaatgatgtc tcaattcatg 378121 taaaggatcg atgggatact gggaaactca ccatagattt tgattaccgc actgatttat 378181 tttcacgtga agaaatcaac atgatttgtg agcgcatgat taccatgctg gagaacgcgt 378241 taacgcatcc agaacataca attgatgaat taacactgat ttctgatgcg gagaaagaga 378301 agctgcttgc gagggccggc ggtaaatctg tgagctaccg taaggacatg acgataccag 378361 agctgttcca agaaaaggct gaactgcttt ctgatcatcc agcggttgta tttgaagatc 378421 gcacattgtc ctatcgaacg ttacatgagc aatctgcacg catcgccaat gtgctgaaac 378481 agaaaggggt tggcccggac agtcctgtcg cggttttgat tgaacgctct gaacggatga 378541 ttacagctat catgggaatt ttaaaagccg gcggagccta tgtgccgatt gatccgggtt 378601 ttcctgctga gcgcattcaa tatattttgg aggactgcgg ggcggatttc atcctgactg 378661 aatcgaaggt tgcggcgcct gaagccgatg ctgagctgat tgacttagat caggcgattg 378721 aggaaggtgc agaagaaagc ctgaatgcag atgtgaacgc tcggaacctt gcctacatta 378781 tttacacatc gggaacaacc ggacgcccga aaggcgttat gatcgagcat cgccaggttc 378841 atcatttggt tgaatctctg cagcagacga tttatcaaag cggcagccaa accctgcgga 378901 tggcattgct tgcgccgttc cactttgatg cgtcagtgaa gcagatcttc gcgtcgcttc 378961 ttttgggcca aaccctttat atcgtaccga agaaaacagt gacgaacggg gccgccctta 379021 ctgcatatta tcggaagaac agcattgagg cgacggacgg aacaccggct catttgcaaa 379081 tgctggcagc agcaggcgat tttgaaggcc taaaactgaa gcacatgctg atcggaggag 379141 aaggcctgtc atctgttgtt gcggacaagc tgctgaagct gtttaaagaa gccggcacag 379201 cgccgcgttt gactaatgtg tacgggccga ctgaaacgtg cgttgacgcg tctgttcatc 379261 cggttatccc tgagaatgca gttcaatcag cgtatgtgcc gatcgggaaa gcgctgggga 379321 ataaccgctt atatattttg gatcaaaaag gccggctgca gcctgaaggc gtggcgggtg 379381 agctttatat cgcgggagac ggtgtgggcc gaggctattt acatttgcct gaattaacgg 379441 aagagaagtt tttacaagat ccattcgtgc cgggcgatcg catgtaccgg accggggacg 379501 tggtgcgctg gcttccagat ggaacaatcg aatatttagg cagagaggat gaccaggtca 379561 aagtccgcgg ataccggatt gagcttgggg aaattgaagc cgtgattcag caggcgccag 379621 acgttgcaaa agccgttgtt ttggcacgcc ctgacgaaca gggaaatctt gaggtttgcg 379681 catatgttgt gcagaagcct ggaagcgaat ttgcgccagc cggtttgagg gagcatgcgg 379741 ccagacagct tcctgactat atggtgccgg cttactttac agaagtgaca gaaattccgc 379801 ttacaccaag cggcaaagtc gaccgccgca agctgtttgc actagaggtg aaggctgtca 379861 gcggcactgc ctatacagcg ccgcgaaatg agactgaaaa agcaatcgca gccatttggc 379921 aggacgtgct gaacgttgag aaggcgggga tctttgacaa tttctttgaa actggcggac 379981 attcattaaa agccatgacc cttttaacaa agattcataa ggaaacaggc attgagattc 380041 cgcttcaatt tttgtttgag catccgacga ttacggctct tgcagaggaa gctgatcaca 380101 gagaaagcaa agcttttgcg gtgattgaac ctgctgaaaa acaggagcat tacccgcttt 380161 cattggcaca gcagcgaaca tatatcgtca gccagttcga ggatgcggga gtcggctata 380221 acatgccagc agcagcaatt ctggaagggc ctttagatat tcaaaagctg gagcgcgcat 380281 ttcagggatt aatccgacgc cacgagtcat tgagaacatc atttgttctt gaaaacagca 380341 cgccgagaca gaaaattcac gatagcgttg atttcaacat cgaaatgatt gaaagaggcg 380401 gccgctcaga tgaggcaatt atggcttcat tcgttcggac atttgatttg gcgaaagctc 380461 cgctgttcag aatcggtttg ctggggcttg aagagaaccg tcatatgctg ctgtttgaca 380521 tgcaccattt gatttctgac ggtgtatcca ttggcattat gctggaggag ttagcacgca 380581 tttataaagg cgaacagctt cctgatcttc gtctccagta taaggactac gctgtatggc 380641 aaagcagaca ggctgctgaa gggtacaaga aggaccaggc ttattggaag gaagtctttg 380701 caggcgagct cccggtgctt cagcttctgt ccgattaccc aagaccacct gttcaaagct 380761 ttgaagggga tcgggtgtca atcaagctgg atgcgggggt aaaggatcgc ctcaatcgtt 380821 tggctgaaca aaacggcgcc actttatata tggtgatgct ttccgcttac tatacgcttt 380881 tgtcaaagta tacggggcag gatgacatca ttgtcgggac accgtcagcg ggcagaaatc 380941 actccgatac agagggcatt atcgggatgt tcgtcaatac gcttgcgatt cgcagtgagg 381001 tgaagcagaa tgagacgttt acccaattga tctcgcgtgt ccgcaaacgg gtgctggatg 381061 ccttttctca tcaggactat ccgtttgagt ggcttgttga agatttgaac atcccgcgtg 381121 atgttagcag gcatccgctg tttgacacga tgttcagcct tcaaaacgcg acagagggca 381181 ttccggctgt cggcgatctt tccttgtctg ttcaagagac caatttcaag attgccaaat 381241 ttgatttgac ggtgcaggcg agagaaaccg atgaaggcat tgagattgat gtggattaca 381301 gcacaaagct gtttaaacaa agcacggcag acaggctgct tacgcatttt gcgcgtttgc 381361 ttgaagatgc tgcggctgat ccagagaagc cgatttctga gtataagctt ctttctgaag 381421 aggaggctgc ttcgcaaatt cagcagttta acccgggcag aacaccttat ccgaaagata 381481 aaacaattgt tcagctgttt gaggagcaag cggcgaatac gccagaccac actgcgcttc 381541 aatatgaagg cgaatcactc acttatcgtg aactgaatga acgggccaat cgtttagccc 381601 gcggcattct ttctcttgga gctggcgaag gcagaactgc ggctgtctta tgcgagcggt 381661 caatggatat gattgtgtcg atcttggcag tattaaaatc aggttcggct tatgttccga 381721 tcgatccgga acatccgatt cagcggatgc agcatttctt ccgtgacagc ggagcaaagg 381781 tgcttctcac tcagaggaaa ttaaaggctt tggcggaaga agcggaattt aagggcgtta 381841 tcgtgctagc cgatgaggaa gaaagctatc atgccgatgc gcgaaatctc gcactgcctc 381901 ttgattctgc agcaatggcc aacctgacgt atacttccgg aacgactgga acacctaagg 381961 ggaatatcgt gacacatgcc aatattctcc gcacggtgaa ggaaacgaat tatctcagca 382021 ttacagaaca ggatacgatt ctcggtcttt ccaattacgt gtttgacgcg tttatgttcg 382081 atatgttcgg ctctttgtta aacggagcca agctggtgct gataccgaag gaaaccgttt 382141 tggacatggc tcgcctgtcc cgcgtcattg aacgggagaa catcagcatt ctcatgatta 382201 caaccgcttt gttccacttg cttgtggact tgaatccggc atgcttgtca acgcttcgca 382261 agattatgtt tggcggggaa cgggcttcgg ttgagcatgt cagaaaagct ttgcaaacgg 382321 ttggaaaggg caagctcctt catatgtatg gaccgtctga aagcacggtt ttcgcgacgt 382381 atcatccggt tgatgaattg gaggagcaca cgctgtctgt tccgattgga aaaccggtca 382441 gcaatacgga agtatacatt cttgaccgta cgggacacgt gcagcctgcc gggattgccg 382501 gagagctttg cgtcagcggc gaaggactcg tgaaaggcta ttacaaccgt ccagaactga 382561 ctgaggagaa atttgttccc catccgttta catccggcga acgcatgtat aaaacgggag 382621 accttgcgag atggctgccg aatggcgaca tcgaatttat cgggcgaatc gaccatcagg 382681 tgaagattcg cggacagcgc atcgagcttg gagaaatcga acatcagctg caaacccatg 382741 atcgtgttca ggaaagtgtt gtgcttgccg ttgatcaagg agcgggagat aaactgttgt 382801 gtgcttacta tgtcggagaa ggagacatct catcacaaga gatgagagag catgctgcga 382861 aggacttgcc ggcatatatg gttcctgcgg tgtttatcca aatggacgag ctgccgctga 382921 cagggaacgg aaaaattgac cggagagcgc tgccgattcc tgatgccaac gtttcaagag 382981 gtgtttcata tgttgcgcca cgcaatggaa cggaacaaaa agtcgcggac atttgggcac 383041 aggtacttca ggcagaacaa gtcggcgctt atgaccactt ctttgacatt ggcggacatt 383101 cattagcagg catgaagatg cttgccttgg ttcatcagga actgggcgtt gagctgtcac 383161 tcaaggatct cttccagtca ccgacggttg agggcttggc acaggtgatt gcctctgctg 383221 aaaaagggac agccgcaagt atcagcccgg cagagaaaca agatacgtat cctgtttctt 383281 caccgcaaaa acggatgtac gtgcttcagc agcttgagga tgcgcaaacg agctataaca 383341 tgccggcggt tctgcgcctg acaggtgagc ttgatgttga aaggcttaac agcgtcatgc 383401 agcagttaat gcagcgtcat gaagccttga gaaccacgtt tgaaataaaa gatggagaaa 383461 cggtgcagcg gatctgggaa gaggctgagt gcgagatagc ctatttcgaa gccccggaag 383521 aagagacaga gcggatcgtt tctgagttta ttaagccttt caaaatcgac caacttccac 383581 tgttcagaat agggcttatc aagcattcag acactgagca tgtgctgctg ttcgatatgc 383641 atcatattat ttctgatggt gcatctgtcg gtgtgctgat tgaggagctt tcaaagctgt 383701 acgacggaga aacccttgag ccgctccgta ttcaatataa ggattatgcc gtgtggcagc 383761 agcagttcat tcagtctgag ctttacaaga agcaagaaga gcattggctg aaggagctgg 383821 acggagagct gccggtgctg acgcttccga ctgattacag tcggcctgcc gttcaaacat 383881 ttgagggaga ccgcattgca ttttcattag aagcaggcaa agctgatgct ctgcgcaggc 383941 ttgcaaaaga aacggattcc acgctttaca tggtgcttct ggcttcatac agtgcgtttt 384001 tatcaaaaat tagcgggcaa gacgatatca tcgtcggttc acctgtggcc ggacgatctc 384061 aagcggacgt cagccgcgtc atcggaatgt tcgtcaatac attggcgctg cgcacgtatc 384121 cgaagggtga aaagacgttt gctgactatc ttaacgaagt gaaagaaacg gcactcagcg 384181 cttttgatgc gcaggattac ccacttgagg atttgatcgg aaatgttcag gttcagcgtg 384241 acacaagcag aaatccgtta ttcgatgcag ttttttcaat gcaaaatgcg aatataaagg 384301 atttaacaat gaaagggatt cagcttgagc cgcatccgtt tgaacggaaa acagccaagt 384361 ttgacctcac gctgacggct gacgaaaccg acggagggct tacattcgta ctcgaataca 384421 atacagctct gtttaagcag gaaacgattg aacgatggaa gcaatattgg atggagcttt 384481 tagatgcagt tactgggaac ccgaaccagc cgctttccag cctgtcactg gtcaccgaga 384541 cagaaaagca agcgcttctt gaggcatgga agggcaaagc gctgcctgtg ccgacagaca 384601 aaacggttca tcagctattc gaagagactg cccagcgcca caaagaccgc ccggctgtca 384661 catacaacgg ccagtcttgg acgtacggcg agctgaatgc gaaggcaaac cgtctcgcgc 384721 ggattctgat ggactgcggc atcagcccgg atgaccgcgt cggcgttctc acgaagccgt 384781 cgcttgaaat gtccgccgcg gtgctcggcg tcttgaaagc cggagcggcg tttgtgccga 384841 ttgatcctga ctatccggat cagcggattg agtatatttt acaggacagc ggcgcgaagc 384901 ttctcttgaa acaggaaggc atttcagtgc cggacagcta tacgggagat gtcattcttc 384961 tcgacggaag ccgcacgatt ctaagcctgc cgcttgatga aaacgacgag gaaaatccag 385021 aaaccgctgt aaccgcggag aacttggcgt acatgattta cacgtctgga acgaccggac 385081 agccgaaggg tgtcatggtc gagcaccatg cgcttgtgaa cctgtgcttc tggcaccacg 385141 acgcgttcag catgacagcg gaggaccgca gtgcgaagta cgcgggcttt gggttcgacg 385201 cttccatttg ggagatgttc ccgacctgga cgatcggtgc cgaacttcac gtcattgagg 385261 aagcgatccg cctcgatatc gtccgcctga acgattattt tgaaacgaac ggcgtaacga 385321 tcacgttcct gccgacacag cttgcggaac agttcatgga gcttgagaac acatcacttc 385381 gcgtattgct tactggagga gacaagctga agcgcgcagt gaaaaagccg tacacactcg 385441 tcaataacta cgggccgaca gagaatacgg tcgttgccac aagcgcagaa atccatccgg 385501 aggaaggctc gctttccatc ggaagggcca ttgccaatac gagagtatac attctcggcg 385561 agggcaatca ggtgcagccg gaaggcgtag ccggagagct ttgcgtggcg gggcgcggac 385621 tggcacgcgg ctatctgaat cgagaagacg aaaccgcgaa gcggtttgtc gctgatccgt 385681 ttgtgccggg tgagcgcatg taccgcaccg gcgatttggt gaaatggacg ggcggcggca 385741 tcgaatacat cggccggatc gaccagcagg tcaaggtccg cggctaccgg atcgagctct 385801 cagaaattga agtccagctc gcccagcttt ctgaggtgca ggatgcggcg gtgacagctg 385861 tcaaagataa aggcggcaac acagcgatcg cggcgtatgt cacaccggaa tcagctgaca 385921 tagaagcact gaaatcagca ctgaaggaaa ccctgccgga ttacatgatc ccggcgttct 385981 gggtgacgct gaacgagctt ccggttacgg caaacggcaa agtggaccgc aaagccttgc 386041 ctgagccgga catcgaagcg ggaagcggag aatacaaagc gccgacgacc gacatggaag 386101 agctgcttgc cggcatctgg caggacgtgc ttggaatgtc tgaagtcggt gtcaccgaca 386161 atttcttctc gcttggcgga gattccatca aaggaattca aatggcgagc cgcttgaacc 386221 agcacggctg gaagctggaa atgaaagatc tcttccagca cccgacgatc gaagagctca 386281 cccagtacgt agagcgtgcc gaaggcaaac aggcagacca aggcccggtg gagggcgaag 386341 tcatcctgac gccgatccag cgctggttct ttgaaaagaa cttcacgaac aagcaccact 386401 ggaaccaatc tgtgatgctt cacgccaaga agggctttga tcctgaacgg gtggagaaaa 386461 cattgcaggc gctgatcgag catcatgacg cgctccgcat ggtctatcgt gagggacagg 386521 aagacgtcat tcaatacaac agaggtcttg aagctgcttc agctcaattg gaggtcatcc 386581 agattgaggg ccaagctgca gattacgaag accgaataga gagagaagcg gagcgtttgc 386641 aaagcagcat cgacttgcag gaaggcggct tgttaaaagc aggcttgttc caagcggaag 386701 acggagatca cttgcttctt gccattcacc acttagtggt tgacggcgtg tcgtggcgga 386761 ttttactgga ggatttcgcc gcggtatata cacagcttga gcaaggcaat gaaccggttc 386821 tcccgcagaa aacacattca tttgcagagt atgcagagag attgcaagac ttcgcgaact 386881 ccaaagcctt tttgaaagaa aaagagtatt ggagacagct tgaagaacaa gctgttgcgg 386941 caaagcttcc gaaagaccgc gaatctggtg atcagcgaat gaaacataca aagacaattg 387001 aattctcgct gactgctgaa gagacagaac agctcaccac aaaggtgcat gaggcatatc 387061 acacagaaat gaatgatatt ttgctgacgg cattcggatt ggcaatgaag gagtggacgg 387121 gtcaagatcg agtaagtgtt catttagagg ggcatggacg tgaagaaatc atagaagacc 387181 tgaccatttc tcgcacagtc ggctggttta caagtatgta cccaatggtg ctcgatatga 387241 agcatgcgga tgatctgggc taccagctga agcaaatgaa agaagatatc agacatgtgc 387301 cgaataaggg agtcggatac ggcattctgc gctatctgac ggcaccggaa cataaagaag 387361 atgtggcgtt ctcgattcag ccggatgtca gcttcaacta tttaggtcag tttgacgaaa 387421 tgtcggatgc aggtttgttt acgagatcag agctgccatc aggacagtca ttaagccctg 387481 aaacagaaaa accgaatgcg ctggatgttg tcggatatat cgaaaacgga aaactgacga 387541 tgtcactggc ctatcattct cttgaatttc atgaaaaaac agtacaaaca ttcagtgaca 387601 gctttaaagc gcatcttctc agaatcattg aacattgcct atctcaagat ggtacggaac 387661 tgaccccgag tgatcttggt gacgacgatt tgacgctgga tgagctggat aaattaatgg 387721 aaattttcta atagaggtgg catatgagca aaaaatcgat tcaaaaggtg tacgcactga 387781 caccaatgca ggagggaatg ctgtatcatg cgatgcttga tccgcattct tcctcgtact 387841 tcacacaatt agagcttggg attcacggcg cttttgatct tgaaatcttt gagaaaagcg 387901 tcaatgaact gattcggtca tacgatattc tccgtacggt atttgtgcat cagcagctgc 387961 aaaaaccgcg tcaggtcgtg ttagcggaac gcaaaacaaa agtgcattat gaggatatca 388021 gtcatgcaga cgaaaaccgc cagaaagagc acattgagcg ttacaaacaa gacgttcagc 388081 gccaaggctt taacctggca aaagacatat tgttcaaggt agcggttttc cgccttgctg 388141 cagatcagct gtatcttgtc tggagcaatc atcatattat gatggacggc tggagcatgg 388201 gcgtcctcat gaaaagcctg ttccaaaact atgaagcgct cagagcaggc aggacaccgg 388261 caaacggtca gggcaagcct tattccgatt acatcaagtg gcttggaaaa caggacaatg 388321 aagaagcgga gagctactgg agcgagcgct tggcgggttt tgaacagcca agcgtgctcc 388381 cgggccgcct gcctgtgaaa aaagacgaat acgtcaataa agaatattca tttacatggg 388441 acgaaacact ggttgcccgt attcagcaaa ccgcaaatct ccatcaagtg acagggccta 388501 acctatttca ggccgtttgg ggcattgttc tcagcaaata caactttacg gatgatgtga 388561 tcttcggaac ggtcgtctcg ggacgaccgt ctgaaatcaa cggaatcgaa acgatggcgg 388621 ggctgtttat caacaccatt ccagtgcggg tgaaagttga acgagatgct gcattcgctg 388681 atattttcac agctgttcag cagcatgcag tagaggcaga gcgttacgat tacgtgccgc 388741 tctatgagat tcaaaaacgc tcagctcttg atggcaatct cttaaaccat ctggtcgcgt 388801 ttgaaaatta tccgcttgat caagagcttg aaaacggcag catggaagac cgcctcgggt 388861 tttcgattaa ggtagaaagc gcatttgaac aaacgagctt cgatttcaac ctgattgtgt 388921 atccgggcaa aacgtggacc gtcaaaatta aatataacgg agccgccttt gattccgctt 388981 ttatcgaacg gacagcggag caccttaccc gcatgatgga agcagctgtc gatcagccgg 389041 ccgcttttgt gcgtgagtac gggcttgtgg gagacgaaga gcagcggcaa attgtcgagg 389101 tgtttaacag cacgaaagcc gaactccctg aaggaatggc tgttcaccaa gtgtttgaag 389161 agcaagcgaa acggacgccg gcgagcaccg ccgtcgtata tgaaggaacc aagctgacgt 389221 accgcgagct gaatgcagcg gctaaccgtc tggcgagaaa gcttgtcgaa catgggcttc 389281 aaaaagggga aacagcagcg attatgaacg accgctcagt agaaaccgtt gtcggcatgc 389341 tggctgtttt aaaagcaggc gccgcatatg tgccgcttga tccagcgctt cctggggatc 389401 gtcttcgttt catggcagag gacagctccg ttcgaatggt tttgatcgga aattcttata 389461 cagggcaggc acatcagctg caagtgccgg ttcttacact ggacataggc tttgaagaga 389521 gtgaagcggc tgacaatctc aacctgccat ccgccccgtc tgatttggcg tacatcatgt 389581 acacatccgg ttcaacgggc aaaccgaaag gcgtcatgat cgaacataaa agcattctgc 389641 gcctcgtcaa aaatgccggg tacgttcctg ttactgaaga agaccgcatg gcgcaaacgg 389701 gagctgtcag ctttgatgcc ggaacgtttg aggtattcgg cgcactgctg aatggcgcag 389761 cactttatcc ggtcaaaaaa gagacactgc ttgatgcgaa acaatttgct gcattcctgc 389821 gtgagcaaag catcacaact atgtggctga catcaccttt attcaaccag cttgctgcaa 389881 aggatgcggg tatgttcggc acactgcgcc atttaatcat cggcggagat gcccttgtcc 389941 cgcatattgt cagcaaagta aaacaggcat cgccgtcgct ttcattgtgg aacggatacg 390001 gcccgacaga aaacacgacg ttttcaacca gttttctgat cgaccgcgag tatggcggct 390061 ctatcccaat cgggaagccg atcggaaatt ccactgccta tattatggat gagcagcaat 390121 gcctgcagcc aatcggcgcg cctggtgagc tttgcgtagg cggaatcggt gtagcgcgtg 390181 ggtatgtcaa tctccctgag ctgacggaga agcaatttct ggaagacccg ttcagaccgg 390241 gtgagagaat ttaccgcact ggtgacttgg caagatggct gccggacggc aatatcgaat 390301 ttttaggcag aatcgacaac caagtgaagg tgcgcggctt ccgaattgag cttggcgaaa 390361 ttgaaacaaa actgaacatg gctgagcatg tgacagaagc cgcggtgatc atacgcaaga 390421 acaaagcaga cgaaaatgaa atttgcgcgt acttcacggc ggatcgtgaa gtggctgtga 390481 gtgagctgag aaaaacactg tctcagtctt tgcctgacta tatggtccct gcccacctga 390541 ttcaaatgga cagcctgccg ctcacgccaa acgggaaaat caacaaaaag gaactgcctg 390601 caccgcaatc agaagccgtg cagccggaat acgcagcacc aaaaacagag agtgaaaaga 390661 aattagcgga gatctgggaa ggaatactcg gcgtcaaagc aggcgttacc gataacttct 390721 ttatgatcgg cggccattct ttgaaagcga tgatgatgac ggcgaaaatt caagagcatt 390781 ttcataagga agttccgata aaagtgcttt ttgaaaagcc gactattcaa gaactggcac 390841 tgtatttgga agagaacgaa agcaaggagg agcagacgtt tgaaccgatc aggcaagcat 390901 cttatcagca gcattatcct gtatccccgg cccagcggag aatgtatatc ctcaatcagc 390961 ttggacaagc aaacacaagc tacaacgtcc ccgctgtact tctgctggag ggagaagtag 391021 ataaagaccg gcttgaaaac gcgattcagc aattaatcaa ccggcacgaa atcctccgta 391081 catcgtttga catgatcgac ggagaggttg tgcaaaccgt tcataaaaac atatcgttcc 391141 agctggaggc tgccaaggga cgggaagaag acgcggaaga gataatcaaa gcatttgttc 391201 agccgtttga attaaaccgc gcgccgctcg tccgttcgaa gcttgtccag ctggaagaaa 391261 aacgccacct gctgctcatt gatatgcatc atattattac tgacggaagt tcaacaggca 391321 ttctaatcgg tgatcttgcc aaaatatatc aaggcgcaga tctggaactg ccacaaattc 391381 actataaaga ttacgcagtt tggcacaaag aacaaactaa ttatcaaaaa gatgaggaat 391441 actggctcga tgtctttaaa ggcgaactgc caatactgga tcttcccgcg gatttcgagc 391501 ggccagctga acggagcttt gcgggagagc gcgtgatgtt tgggcttgat aagcaaatca 391561 cggctcaaat caaatcgctc atggcagaaa cagatacgac aatgtacatg tttttgctgg 391621 cggcgttcaa tgtactcctt tccaagtacg cgtcacagga tgatatcatt gtcggctcgc 391681 cgacagctgg cagaacacat cctgatctgc aaggtgtgcc gggtatgttt gtcaacacgg 391741 tggcactcag aacggcacca gcgggagata aaaccttcgc gcaattcctt gaagaggtca 391801 aaacagccag ccttcaagca ttcgagcacc agagctatcc gcttgaggag ctgattgaaa 391861 agcttccgct tacaagggat acaagcagaa gtccgctgtt cagcgtgatg ttcaacatgc 391921 agaatatgga gattccttca ttaagattag gagatttgaa gatttcctcg tattccatgc 391981 ttcatcatgt tgcgaaattt gatctttcct tggaagcggt cgagcgtgaa gaggatatcg 392041 gcctaagctt tgactatgcg actgccttgt ttaaggacga gacgatccgc cgctggagcc 392101 gccactttgt caatatcatc aaagcggccg cggctaatcc gaacgttcgg ctgtctgatg 392161 tagatctgct ttcatctgca gaaacggctg ctttgctaga agaaagacat atgactcaaa 392221 ttaccgaagc aacctttgca gcactttttg aaaaacaggc ccagcaaaca cctgaccatt 392281 ctgcggtgaa ggctggcgga aatctgttga cctatcgcga gcttgatgaa caggcgaacc 392341 agctggcgca tcatcttcgt gcccaagggg caggaaatga agacatcgtc gcgattgtta 392401 tggaccggtc agctgaagtc atggtatcca ttctcggtgt catgaaggcg ggggcagctt 392461 tccttccgat tgatcctgat acacctgaag aacgaatccg ttattcatta gaggacagcg 392521 gagcaaaatt tgcggtcgtg aatgaaagaa acatgacggc tattgggcaa tatgaaggga 392581 taattgtcag ccttgatgac ggtaaatgga gaaatgaaag caaggagcgc ccatcatcca 392641 tttccgggtc tcgcaatctt gcatacgtca tttatacgtc cggtacgacc ggaaagccaa 392701 agggcgtgca gattgagcat cgtaatctga caaactatgt ctcttggttt agtgaagagg 392761 cgggcctgac ggaaaatgat aagactgtat tgctttcatc ttacgcattt gaccttggct 392821 atacgagcat gttccctgta cttctgggcg ggggcgagct ccatatcgtc cagaaggaaa 392881 cctatacggc gccggatgaa atagcgcact atatcaagga gcatgggatc acttatatca 392941 agctgacacc gtctctgttc catacaatag tgaacaccgc cagttttgca aaagatgcga 393001 actttgaatc cttgcgcttg atcgtcttgg gaggagaaaa aatcatcccg actgatgtta 393061 tcgccttccg taagatgtat ggacataccg aatttatcaa tcactacggc ccgacagaag 393121 caacgatcgg cgccatcgcc gggcgggttg atctgtatga gccggatgca tttgcgaaac 393181 gcccgacaat cggacgcccg attgcgaatg ccggtgcgct tgtcttaaat gaagcattga 393241 agcttgtgcc gcctggagcg agcggacagc tctatatcac gggacagggg ctcgcgagag 393301 ggtatctcaa caggcctcag ctgacagccg agagatttgt agaaaatcca tattcgccgg 393361 gaagcctcat gtacaaaacc ggagatgtcg tacgaagact ttctgacggt acgcttgcat 393421 ttatcggccg ggctgatgat caggtgaaaa tccgaggcta ccgcattgag ccgaaagaaa 393481 ttgaaacggt catgctcagc ctcagcggaa ttcaagaagc ggttgtacta gcggtttccg 393541 agggcggtct tcaagagctt tgcgcgtatt atacgtcgga tcaagatatt gaaaaagcag 393601 agctccggta ccagctttcc ctaacactgc cgtctcatat gattcctgct ttctttgtgc 393661 aggttgacgc gattccgctg acggcaaacg gaaaaaccga cagaaacgct ctgccgaagc 393721 ctaacgcggc acaatccgga ggcaaggcct tggccgcacc ggagacagcg cttgaagaaa 393781 gtttatgccg catttggcag aaaacgcttg gcatagaagc catcggcatt gatgacaatt 393841 ttttcgattt aggcggccat tcattaaaag ggatgatgct gattgccaac attcaggcgg 393901 aattggagaa aagcgtaccg cttaaagcac tgttcgagca gccgacagtt cgccagctgg 393961 cggcttatat ggaggcgtct gctgtttcag gcggccatca agtactcaaa ccggctgaca 394021 agcaggatat gtatccattg tcatccgcac agaaacgaat gtacgtgctc aatcagcttg 394081 accgccagac gataagctac aacatgccat ctgttcttct aatggaagga gagcttgata 394141 tttcgcgcct gcgcgactca ctcaatcagc ttgtgaaccg tcacgaatca ttgcggacgt 394201 catttatgga agctaatggt gagcctgttc agcgcatcat tgagaaggcg gaggttgatc 394261 ttcatgtgtt tgaagccaaa gaagacgaag cggaccaaaa gattaaggaa tttatccggc 394321 cattcgactt aaacgacgca ccgctcattc gcgcagcttt gcttcgaata gaagcgaaaa 394381 aacatttgct gcttttagat atgcatcata tcatcgcaga cggcgtctca agaggcatct 394441 ttgtaaaaga attggcgctg ctttacaaag gagagcagct tccggagccg acgcttcatt 394501 ataaagattt cgccgtttgg caaaatgaag ctgagcaaaa agaacggatg aaggagcatg 394561 aggcgtactg gatgtcagtt ctttcaggcg agctgccaga gcttgatctc ccgctcgatt 394621 atgcccgtcc gcctgtgcaa agctttaaag gagatacgat ccgtttccgt acgggaagtg 394681 agacggcaaa ggcggtagaa aaactgcttg ccgaaaccgg aacgaccttg cacatggtgc 394741 tccatgctgt tttccacgtc tttttaagca aaatttccgg acagcgggat atcgtcatcg 394801 gctccgttac tgccggccgg acgaatgctg atgttcagga catgccggga atgttcgtca 394861 atacacttgc cctgagaatg gaagcgaaag aacagcaaac atttgcggag cttttggagc 394921 tagcaaagca gacgaacctg tcagcccttg agcatcagga gtatccgttt gaagatctgg 394981 ttaatcagct tgatctccct cgggatatga gccgaaaccc attgtttaat gtgatggtga 395041 cgacagaaaa ccctgataaa gaacagctta cattgcaaaa tctgagcatt tcaccttatg 395101 aggctcatca gggaacttct aagtttgatc tgacactggg cggatttact gatgaaaatg 395161 gcattggctt gcagctcgaa tatgcgacag atctgttcgc aaaagaaaca gctgaaaaat 395221 ggagcgaata cgttctgcgg ctactaaagg ctgttgcgga taacccgaac cagccgcttt 395281 ccagtctgtt actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca 395341 aagcgctgcc tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgtccagc 395401 gccacaaaga ccgcccggct gtcacataca acggccaatc ttggacgtac ggcgagctga 395461 acgcgaaggc aaaccgcctc gcccggattc tgatggactg cggcatcagc ccggatgacc 395521 gcgtcggcgt tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga 395581 aagccggagc ggcgtttgtg ccgattgatc ctgactaccc ggatcagcgg attgagtata 395641 ttttacagga cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca 395701 gctatacggg agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg 395761 atgaaaacga cgagggaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga 395821 tttacacgtc tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg 395881 tgaacctgtg cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga 395941 agtacgcggg cttcgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg 396001 gcgctgaact tcacgtcatt gatgaagcga tccgcctcga tatcgtccgc ctgaacgatt 396061 attttgaaac gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca 396121 tggagcttga gaacacatca cttcgcgtcc tcttgaccgg aggagacaag ctgaagcggg 396181 cagtgaaaaa gccgtacaca ctcgtcaaca actacgggcc gacagaaaat acggtcgttg 396241 ccacaagcgc agaaatccat ccggaggaag gctcgctttc catcggacgg gccattgcca 396301 atacgagagt atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag 396361 agctttgcgt ggcggggcgc ggactggcac gaggctatct gaatcgagaa gacgaaaccg 396421 cgaagcggtt tgtcgctgat ccgtttgtgc cgggtgaacg catgtaccgc accggcgact 396481 tggtgaagtg ggtgaacggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg 396541 tccgcggcta ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg 396601 tgcaggatgc ggcggtgaca gctgtcaaag ataaaggcgg caatacagcg atcgcggcgt 396661 atgtcacacc ggaaacagct gacatagaag cactaaaatc aacactaaag gaaaccctgc 396721 cggattacat gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg 396781 gcaaagtcga ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca 396841 aagcgccgac gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa 396901 tgtctgaagt cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa 396961 ttcaaatggc gagccgcttg aatcagcacg gctggaagct ggaaatgaaa gatctcttcc 397021 agcatccgac gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag 397081 accaaggccc ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa 397141 agaacttcac gaacaagcac cactggaacc aatcggtgat gcttcacgcc aaaaagggct 397201 ttgatcctga acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc 397261 gcatggtcta ccgcgaggaa aacggggaca tcgttcaggt gtataaaccg atcggtgaga 397321 gcaaggtcag cttcgaaatc gtggatctgt acggctccga tgaagagatg ctgagaagcc 397381 agattaagct tctcgcgaac aagctgcaaa gcagtctcga tctgcgaaac gggccgcttt 397441 taaaggcgga gcaatatcgc acagaagctg gggatcacct gctcattgct gtacaccatc 397501 tcgtggtcga cggtgtgtca tggcggattt tgcttgaaga ctttgcttca ggctacatgc 397561 aggctgagaa agaagagagc cttgtcttcc cgcaaaaaac aaactccttc aaggattggg 397621 cggaagaact ggcggcattc agccaatcag cgcatctttt acagcaggct gaatactggt 397681 cgcaaattgc cgctgaacag gtttctcctt tacctaagga ttgtgaaaca gagcagcgga 397741 tcgtcaagga tacatcatct gtcctatgtg aattaacggc agaagacact aagcatcttt 397801 taacagatgt tcatcagcca tatggaactg aaatcaacga tattcttctc agcgcgctcg 397861 gtttgacaat gaaagaatgg acaaaggggg ccaaaattgg cattaacctt gagggacacg 397921 gccgggagga cattatcccg aatgtgaata tctccagaac ggtcggctgg tttacggcac 397981 aataccctgt tgtgctcgac atatctgacg cagatgcctc agctgtgatc aaaacagtca 398041 aagaaaacct gcgccgcatt ccggacaaag gtgttggcta cggcattctt cgttatttca 398101 cagaaacagc ggaaacaaag ggcttcacac cggagatcag cttcaactat ttgggccaat 398161 tcgacagtga agtcaaaacc gatttctttg aaccgtccgc tttcgatatg gggcgccaag 398221 taagcggaga atcagaggcg ctgtacgcat taagcttcag cggcatgatc agaaacggcc 398281 ggtttgtgct ttcctgctcc tacaatgaga aggagtttga aagagctaca gtcgaggagc 398341 aaatggaacg gtttaaagaa aacctcctga tgctaatccg ccattgcacg gaaaaagaag 398401 acaaggaatt cacaccaagc gacttcagcg ccgaagacct tgaaatggac gagatgggag 398461 atatctttga catgcttgag gagaatttaa aataaaacgc aagggaatta cagaaggcgg 398521 gagcgaaaca tatgagtcaa tttagcaagg atcaggttca agatatgtat tacctatcgc 398581 cgatgcagga agggatgctt tttcatgcca tcctgaatcc cggccaaagc ttttaccttg 398641 aacaaatcac gatgaaagta aaaggcagct tgaatatcaa atgtcttgaa gaaagcatga 398701 atgtgatcat ggaccggtac gatgtatttc gtaccgtgtt cattcacgaa aaagtaaaaa 398761 ggcctgtcca agtcgtattg aaaaaacggc agttccatat agaagaaatc gatctgacac 398821 acttaacggg cagcgagcaa acagccaaaa tcaatgagta caaagaacag gataagatca 398881 ggggttttga tttgacgcgg gatattccga tgcgggcagc cattttcaag aaagctgaag 398941 aaagctttga atgggtgtgg agctaccacc acattatttt ggacggatgg tgcttcggca 399001 tcgtcgtaca ggatctattt aaggtataca atgctctgcg cgaacaaaag ccgtacagcc 399061 tgccgcccgt caaaccgtat aaagactaca tcaagtggct tgaaaagcag gataaacaag 399121 catcactgcg ttactggcgc gaatatttag agggctttga aggacaaacg acgtttgcgg 399181 agcaaagaaa gaaacaaaag gacggctatg agccgaaaga gctgctcttt tcactgtcgg 399241 aggcggaaac aaaggccttt accgagcttg caaaatcgca gcataccact ttgagtacgg 399301 cgctgcaggc agtctggagc gtattgatca gccgctatca gcagtctggc gatttggcct 399361 tcggtacagt tgtttcaggg cgtcccgcgg aaatcaaagg cgttgaacat atggtcgggc 399421 tgtttatcaa cgttgtcccg agacgtgtga agctgtctga gggtatcaca tttaacggct 399481 tgctcaagcg gctgcaggag caatcgctgc agtccgagcc gcatcaatat gtgccgcttt 399541 atgacatcca aagccaggcc gatcagccga aactgattga ccacatcatt gtttttgaga 399601 actatccgct tcaggatgcg aaaaatgaag aaagcagtga aaacggcttt gatatggtgg 399661 atgttcatgt ttttgagaag tcgaattatg atctcaacct gatggcttcc ccgggagatg 399721 agatgctgat taagcttgcc tataatgaga atgtgtttga tgaggcgttt atcctgcgct 399781 tgaaatctca gcttcttaca gcaattcagc agctcatcca gaatcctgat cagcctgtca 399841 gcacgatcaa cctcgttgac gacagggaga gagaattttt gctaaccggc ttaaacccgc 399901 cggctcaagc tcatgaaaca aagcctctga cgtattggtt caaggaagca gtgaacgcca 399961 atccggatgc accggcgctt acgtattccg gccagaccct gtcttatcgc gaattagatg 400021 aggaagcgaa ccgcattgca cgccggctgc aaaaacacgg tgcgggcaaa ggctctgttg 400081 tagcgctgta cacgaagcgc tcacttgaac tggtgatcgg cattctcggt gtattaaagg 400141 cgggagcagc ctatctgccg gttgatccga agctgccaga ggaccgaatc tcgtatatgc 400201 tggctgacag tgcggcagcc tgtcttctga cgcatcagga gatgaaagaa caagcggctg 400261 agctgccgta tacaggcaca acgctcttca ttgatgatca aacacggttt gaagaacagg 400321 caagcgatcc tgcaaccgcg attgatccta atgatccggc atatatcatg tacacgtccg 400381 gcacaaccgg aaagccaaag ggcaatatca ccactcatgc caatattcaa ggattggtca 400441 agcatgtaga ctacatggca ttttctgatc aggatacgtt cttgtctgtt tcgaattacg 400501 cctttgatgc atttaccttt gatttctatg cttctatgct gaatgcggca cggctcatta 400561 tcgcagatga acatacgctg cttgatacag aacggctcac agatctgatc ctgcaagaga 400621 atgtcaatgt catgtttgcg acaaccgcac tatttaatct tctcacagat gcgggagagg 400681 attggatgaa ggggcttcgc tgtatattat tcggcggaga gcgcgcgtca gtgcctcatg 400741 tcagaaaagc gctgcggatc atggggccgg gcaagctgat taactgctac gggccgactg 400801 agggaacagt gtttgcgaca gctcacgtcg tgcatgatct gccggattcc atctcctcat 400861 tgccgatcgg aaagccgatc agcaatgcca gtgtttatat tctgaatgag caaagccagc 400921 tccagccatt cggggcggtc ggtgaactgt gcatcagcgg aatgggcgtg tcaaaagggt 400981 atgtaaatcg tgctgacctc acgaaggaaa agtttatcga gaacccgttc aagccgggag 401041 aaacgcttta ccgtacaggg gatttagcgc gctggctgcc ggatggaacg attgaatacg 401101 ccggccgtat tgacgaccag gtcaaaatac gcggacaccg gattgagctt gaagaaatcg 401161 aaaagcagct gcaggaatac ccaggtgtga aagatgcggt cgttgtggcg gaccgccatg 401221 agtctggcga tgcatcaatc aatgcctacc ttgtgaaccg aacgcagctt tcagctgaag 401281 acgtgaaggc gcacctgaaa aaacagcttc ctgcttacat ggtgccgcaa acctttacct 401341 tcttggatga gcttccttta acgacgaacg ggaaagtcaa taaacggctg ctcccaaaac 401401 ctgatcagga tcagctggcg gaagaatgga ttggaccgcg gaacgagatg gaagaaacaa 401461 tcgcacaaat atggtctgag gttctcggca gaaagcaaat tggcattcat gacgatttct 401521 ttgcgctcgg agggcattcc ttgaaggcca tgaccgccgc gtcccgcatc aagaaagagc 401581 tcgggattga tcttccagtg aagcttttgt ttgaagcgcc gacgatcgcc ggcatttcag 401641 cgtatttgaa aaacgggggc tctgatggct tgcaggatgt aacgataatg aatcaggatc 401701 aggagcagat cattttcgca tttccgccgg ttctgggcta tggccttatg taccaaaatc 401761 tgtccagccg cttgccgtca tacaagctat gcgcctttga ttttattgag gaggaagacc 401821 ggcttgaccg ctatgcggat ttgatccaga agctgcagcc ggaagggcct ttaacattgt 401881 ttggatattc agcgggatgc agcctggcgt ttgaagctgc gaaaaagctt gaggaacaag 401941 gccgtattgt tcagcggatc atcatggtgg attcctataa aaaacaaggt gtcagtgatc 402001 tggacggacg cacggttgaa agtgatgtcg aagcgttgat gaatgtcaat cgggacaatg 402061 aagcgctcaa cagcgaagcc gtcaaacacg gcctcaagca aaaaacacat gccttttact 402121 catactacgt caacctgatc agcacaggcc aggtgaaagc agatattgat ctgttgactt 402181 ccggcgctga ttttgacatg ccggaatggc ttgcatcatg ggaagaagct acaacaggtg 402241 tttaccgtgt gaaaagaggc ttcggaacac acgcagaaat gctgcagggc gaaacgctag 402301 ataggaatgc ggagattttg ctcgaatttc ttaatacaca aaccgtaacg gtttcataaa 402361 tgaagtgatg aaaggaggag acagccaatg agccaactct tcaaatcatt tgatgcgtcg 402421 gaaaaaacac agctcatctg ttttccgttt gccggcggct attcggcgtc gtttcgccct 402481 ctccatgctt ttttgcaggg ggagtgcgag atgctcgctg ccgagccgcc gggacacggc 402541 acgaatcaaa cgtcagccat tgaggatctc gaagagctga cggatttgta caagcaagaa 402601 ctgaaccttc gccctgatcg gccgtttgtg ctgttcggac acagtatggg cggaatgatc 402661 accttcaggc tggcgcaaaa gcttgagcgt gaaggcatct ttccgcaggc ggttatcatt 402721 tctgcaatcc agccgcctca tattcagcgg aagaaagtgt cccacctgcc tgatgatcag 402781 tttctcgatc atattatcca attaggcgga atgcccgcag agcttgttga aaataaggag 402841 gtcatgtcct ttttcctgcc ttctttccga tcagattacc gggctcttga acaatttgag 402901 ctttacgatc tggcccagat ccagtcgcct gttcatgtct ttaacgggct tgatgataaa 402961 aaatgcatac gagatgcgga agggtggaag aagtgggcaa aagacatcac attccatcaa 403021 tttgacggcg ggcacatgtt cctgctgtca caaacggaag aagtcgcaga acggattttt 403081 gcgatcttga atcagcatcc gatcattcaa ccgtgatcaa aagcggacag cttcggctgt 403141 tccgcttttt ttgtgttgaa tgccaatttc tgcatggtat aatagtcgaa atactcaaat 403201 aaaggcaggt cgaaacatgc gcacgtctcc caggatgaaa tggtttgtat tgctgtttac 403261 gtttgttttc gccatcggaa tgaactcatt cagaaattcc tttcaatttt ttatgctgcc 403321 aatggcagac gccttccatg ccgacaggtc gctgatttcg gtttctgtca gcatttttat 403381 gatcacaacc ggcatcgtcc agttttttgt cggttttttt atcgaccgtt tcagtgtcag 403441 aaaaattatg gcgctgggag ctgtttgcat cagcgcaagc tttttggtgc ttccttattc 403501 accgaatgtt catgtgtttt ccgccattta cggtgtgctt ggcggaatcg ggtattcctg 403561 cgcggtcggc gtgacgaccc agtatttcat cagctgttgg tttgacacac acaaaggtct 403621 ggcgcttgct attttgacca atgccaactc tgcgggcctg ctgcttctct cgcccatttg 403681 ggctgcggct ccgtatcatg ccggctggca gagcacctat accattttgg gaatcgtcat 403741 ggcggctgtt ctgctgccgc tcctcgtctt tgggatgaag cacccgccac atgcgcaagc 403801 ggaaactgtg aaaaaatctt atgattggcg agggttttgg aacgtgatga agcaatcccg 403861 cctcattcat atcctgtact tcggcgtgtt tacttgcgga tttacaatgg gaattattga 403921 tgctcacctc gtcccgatac tgaaggatgc gcatgtctct catgtcaacg gaatgatggc 403981 cgcgttcggg gcatttatca tcattggcgg attattggcg ggctggctgt cagatctcct 404041 cggcagcaga agcgtcatgc tatccatctt atttttcatt cggctgctca gcctcatttg 404101 cctgctcatt cccattctcg gaattcatca cagcgacctt tggtacttcg ggtttatcct 404161 gttattcggg ctcagttaca caggcgtgat cccgctgacc gcggcgtcaa tttcggaaag 404221 ctatcaaaca ggattgatcg gatcgctgtt aggcatcaat ttctttatcc atcaggttgc 404281 cggagctctc agcgtgtatg cgggcggttt gttttttgac atgactcatg gttatttact 404341 gattgtcgct gtgtgcatcg tgtttgtggg tttatcggct gtaatagagc tggtgccgtt 404401 tttagataaa cagaaggcaa aagaaaccca ccattcaata taaaaggatc agcactgtca 404461 atgctgatcc tttttaaatt tgagtttttt tgtttcggta tttttaagga taatctcctt 404521 gaatctgttc atctcctctt cggagtgaaa aaaatgtttg gggatcgcaa tatattggcc 404581 acttgatgta ttgaccctga agatattttt atattcgaaa acagctgtaa tttcatccca 404641 attgaaaatg aggtcatatt ttttagaaca tatacgaatt ccttcttggt tcagagtata 404701 tgttcttttg gatttcatcc gttcgttctt cttgtatgct ctggaaaact tcacatatag 404761 aagaaggagg agcagcagtg taaacagaac ggacatcacg ataatcaaca tactgttcat 404821 aaacaagtta agcgcgtcac ttccataaac gatacggggc catccgttaa tgaagttaac 404881 tgcagcaaat atggcgcaaa acaatagaaa gtaaaagcat gatatttttg cgatttgata 404941 aaaaaagatt tctcttacat ccttaaaagt gatttctcct ggaagattga tactttcact 405001 agcatattga atcatacggt aaacctacac ctctaaccat gtttttcctt ttagtctagc 405061 ataatttctc atttttttgc aggcatacca gggcgctttg tttttttctc cagattgata 405121 ttgctcccca ccacgccaat cataatacaa acagccccgg caagatgata ccaggccagg 405181 ctttcgttga gaatcacaaa tcctgcaatc atcgtcacaa tggtagatac atgattaaaa 405241 gcgctcattt taaacgcctc aattcgcgac agcgtatagt tagacagaaa tgaagtgaca 405301 agtgaagaca gcacgcccaa atacacaatg gcgagaacga agccgggctc ccggaacggc 405361 agaaaataag tgccgactgt tcccgccgct ccgtgacgca caagggcgat ggcgttgaag 405421 acgacaaagc cgatggctga catgatgtag gtgagctcgg tcagcttgaa ccgctgcgtc 405481 atttttctgg cagcagtatt gtacatcgct gaagacaaag cggacaatag gatcagcaaa 405541 gaccctttta agctggctga ttccacgtca acgcctttca tcacaaaaat aaacatgacg 405601 ccggcaacgg ataaaaccgt gaaccccttt tgcgtccacg ttgggcgttc ctttaaaaca 405661 taagcggcaa agaccatcgt gaaaatcgga atggctgcct gaataattcc cgcttcagag 405721 gaggacgagt acacaaggcc gaatgcctga aagctgaaaa ataacgcggg atacagcagg 405781 gcgagcggca aaatgtcaat gacgtccttt acgcggattg atagctttac ccagccgaat 405841 aagatcggta cagtggccgc agcaaacgca atggtgaacc gatgcgccaa aatatcaaac 405901 ggctctgctg tttgcagtgc gatttttacg aatagaaagg ataaaccgat aatgaacgaa 405961 tataaaatag ccgctatata agcgggggtt tgctgatgtt taaccataat gggaagggct 406021 cctttacctg aattgcagcg ccggtcgctc cctttattgt atggccgcgg tcagaacggt 406081 acaatgagaa aaacaatgaa ctgtaccggt acaaaacagg gggagaaggc atggagaaat 406141 atatgagtct attaacgagg atagaggaga tgatgcaaag cacctcatat caagaaggag 406201 acaggcttcc atctatccgt cagctgtccg cccgctacca agtcagcaaa agcacagtga 406261 tccgcgcgct gcaggagctg gaaaagcgcc accttatcta ttctgttccg aaaagcggct 406321 attatattgt gaaaaagtca gggaaatcaa aaagcgggca gcctggcccc atcgactttg 406381 ccacatctgc gccggatccc gatgtgtttc cgtatcttga ttttcagcac tgcatcaaca 406441 aagcgattga tacatacaaa aacgatttgt ttatttatgg gacgccaaag gggcttccat 406501 cactcatccg cgtactccga aagctcttgg ccactcaaca ggtatttgcg gatgaacggc 406561 atattttcat tacatcaggt gtccagcagg cgttatcctt gctttgtgcc atgccgttcc 406621 caaatgggaa agagaagatc gccattgaac agccgggcta ccatttgatg gtcgaacagc 406681 ttgagacact tgggattccc gccatcgggg tgaaacgaac ggaagaaggg cttgatatag 406741 ccaaggttga gcggttattt caaacagaat cgattaaatt tttttatacg atgccgcgct 406801 tccataaccc gcttgggtgc tcattgtcag agcgtgataa acaggagctt gtgagactgg 406861 cagaagcgta tgatgtctat ctcgttgagg atgattacct cggtgatctg gaggaaaata 406921 aaaaggcaga tccgctgtac gcatatgatc tgtcctcaca tgtcatctat ttgaaaagct 406981 tctcgaaaat gatgttcccc ggcctccgcg tgggggcggc tgttttgccc gaagcgctga 407041 ctgacacgtt ctatgcgtac aaaaagctga acgacatcga ctgttcgatg atttctcaag 407101 cggcattgga gatttacctg aaaagcggta tgtacggcag gcataaggag aaaatcagag 407161 attcttataa agagcggtcg ctgaggctac atcaagccat tcgaactcac aggcagctgg 407221 gaagcggacg ctttacgttc tccagcgggc aggcaccctg tatgcacacc catctggtgc 407281 ttcctcagga tctgcccgcc tcaagagtga ttcatagact ggaaaaacaa ggggttctcc 407341 ttgaggcgat agaccgtcat tatttatcag attatccgaa agaaaatcta ttaaaaatca 407401 atatttccaa tgtgaaaacg gaagatattg agcgcggtgt caagctgttg atgagccatt 407461 tataaaagct cttcgtacga gaccattgtg atatcctcgg ggaaatcagg gtgtacggcg 407521 catacagcca ttttgtagcc gggatcgacc tcatacgttt tgatatagca tggggaatgg 407581 ctgtccggaa gctcaatgga tacttgtccg tcctggtgca ggcgcactga aaaggaatca 407641 agcggaagcg ataagccttt gccttccttg tttgataaag ctttctttca ttgaccatag 407701 atgataaaaa tagtctgtct gctcgtcctt gtcttttgct aaaaggtcgc tgtactctgt 407761 ttttgaaaag aagcgcttgg cgatctcaag gctgatcggt ttcgtttttt cgatatctat 407821 gccgatcggc tgtgaatcaa acgcgcaaat gacccagcgt ccggagtgag aaatgttgaa 407881 atgagcgtcg ggaagatcag ggatgcacgg cttcccgtat tcctgcgtgc taaagcggat 407941 atcggatttg tccaactgat actgcctgct tatgactgag cgaacgagca catctcccag 408001 cagggtgcgg tgagcatctt ctttatgata aaatctccgg catttctccc gtttttcagg 408061 tgatatgaaa gacatgaacc gttcattttc ttcctgtgaa agcgggcggt ccatataaat 408121 tccgtaaatc ttcattctag atcctccgtc tgcaaaagat tgtcaaaacc atcctatcat 408181 acttccacaa gactcatata gaggagaaaa taaaaaaaca aagccaaggc ggctttgttt 408241 tagtgtacag gcggagatgc tttcactgcg gctgtccgcc ttgccacagc ataattcagc 408301 aactggattg actggggcaa tgaaaaacgc aaaataagtc cggtgaggat ggcggtcaaa 408361 atggtgccaa aaccgatcgg tccgcccatg ccccatgccg caaacaaaat ggttaattcc 408421 atgccgttcc gcacccattg cacattccag ccggtttttt ctgtaatcag catcatcagt 408481 gaatcacgcg gccccgcgcc aaggcctgct gatacataaa caccgacgcc gtaaccaatc 408541 agcaccacgc ctagagagaa gacgatgatc gagcctgtgt aggtcgagag ggcaggcaga 408601 atgaaattga aaaaatctat aaatacacca atgagcacca tattcaggag ggcaccaatt 408661 ttcggccaag ctctcgtaaa caatgacgtg aatccgacga tgagcgctcc aataatgatg 408721 gaccactggc cgacggtaag cccgaagtgc tgaaacaggc tgtaatgaaa tgcatcccac 408781 ggactaatgc cgagtgcttt tccttctatc gtcagggata caccaaaagc caaaatgatc 408841 aaaccggcaa aataaaatgt ccagcgcaga acaagttctt gcttcacgtg aggtcccttc 408901 tttcgtaaaa atcagtcgat tgtcattgta gcacatctga cagaagggcg gaataggcga 408961 aaggggctca acaaaaaaac agggccgccg gaggcgccct gtttcagcgt gttggcaaac 409021 ccttgcattc gttgtcaggc ctgtgcttcg gtgctcacga atttaacatt agctgtgctc 409081 caatgctcgc ccttcctaga cttcaaaggt tttcaatcac gctgaaaatc acaaaatcct 409141 aaaacgaata tcgttttagg attttgtcaa taatctgaaa cagggcgctg acgctctgtt 409201 tttcttatta cagcgggttc aaaatccggt ttaagaaccg ctgtgtccgt tcttcttttg 409261 gtgcggagaa aatttgctcc ggcggtccct gctccacgat aacgccgccg tcgatgaaga 409321 tgacttcatc cgcaacctcc tgcgcgaact tgatttcgtg ggtcacgacg accatggtcc 409381 agccttcatt ggccaagtcc ttgataacct tcagcacctc tccgacaagc tcgggatcaa 409441 gcgctgaggt cggttcgtca aacagcatga gctcaggctg tatcgccagt gcgcgggcga 409501 tgccgacgcg ctgctgctgg ccgccggaaa gctggaacgg atataaatcc attttgtcct 409561 tcaatccgac tttatcaaga agctgaatcg cttcttttct gacttcctct ttgttccgtt 409621 tttgcacctg aacagggccc tccatcacgt tttcgagggc tgtgcggtgc gggaacaggt 409681 gatacgcctg aaacaccatt ccggattttc ggcgaagctt taggatatcc gcctgtttca 409741 cctttttgga gaaatcgatg gagaaatcat caaatgcaag ctctccgcga ttcgggatct 409801 ccagagcgtt caggcagcgg agcagcgtcg ttttccctga acctgaaggc ccaagtatgg 409861 cgatgacttt tcctttttca atcttcatat ctatcttttt taaaatttca ttttcaccga 409921 atgatttgtt taatccttta acggtaagca tactcggaac ctccttattt ggccacgtag 409981 cggtcaagac gccgttcgat gacatgctgg acgagtgaga gcaggaagca gataatccaa 410041 taaataaagg ctgcttcaat atagatcact aaaatttgat caagattccg cgcgccgatt 410101 tcctgggctt ttctgaacag ctcagcgacc agaatttgag aggcgaggga tgtatcttta 410161 atcaggctga taaaggtatt ggataatggc gggatcgaca cacgaaacgc ctgcggcaaa 410221 atgacgcgga acagcgtttt ttgatgtgtc atgccaattg tgtagccggc ttcccattgc 410281 cctttcggca cggataaaat agatgcccga atgatttcag atgcataggc gccgacgttt 410341 aatgaaaagg cgataactgc gcttggaaat ggatctaatg tgacgttaaa ggccgggaac 410401 agatagaaaa tgatgaacaa ttgaacgaga agaggagtgc cgcgtattgc ggatacgtat 410461 acgctgaaca cccatctcaa aggtctcact ttcgacattc tggcaagcgc cgtaatcagc 410521 gccaggatca ttccgaatat aaaggaaaga atcgtaaggg gaatcgtata gtagattccc 410581 cctgaaagta tcggccagaa tgactgctgc accagatccc acgggatcgc cgtgccaagc 410641 gtcaatgccg gcagattatt tagaaacatc ttcgccgaac cattttttag aaattttaga 410701 aagagtcccg tcctctttca tttcttttaa tgctttgttg acttgatcaa caacctcgcc 410761 gcttccttta cggaacgtga aatatgttga ctgaggctca cctgtttcaa acgcgatttt 410821 cacgttttta ttgccagatg tttttaagta gttcaatacg gcaagcttat cgttgtatgt 410881 catatcgacg cggccttgct ggatcatttg aagggcctgc gccatgcctt caacgccttc 410941 tactttagcg ccggcatttg tagctaattt gttgtagttg cttgtcagtg attgagctga 411001 cgtttttcct tttacatctg cttcagactt aatatcgttg ttgtcttttt tcgttacgac 411061 aacggctctt gatgttgtgt atttatctga gaaatcatat ttgtcttcac gatctgtttt 411121 tccgacttgg ttggcaacaa cgtcaaaccg tttggaattc aggccggcaa acatactgtc 411181 ccattgtgtt tccttaaagt cgactttaag cccgaggcgt tttgcgactt ctgtgataac 411241 ttcgacatca tagccagtca gtttatcagt gtctttgtcg tggtaagtga acggctcata 411301 tgttccttcc gttccgactg tgagcacacc ttttttctta attgaagccc aaagatcgcc 411361 atctttggca ttatcttttg actgattgtc atttcctgct ccgcaagctg caagagctgc 411421 aatacttacg accatgaata aagccaataa tgcttttttc atcttattcc ccacttttct 411481 ggttgatttt attgaaataa aaaattagct tacaaatcta aaggataact tttttttagt 411541 atgagtcaag tatttggttt tcataagaca aaatctttta aaataaatcc aaaaattgct 411601 gtgccggttt aggcaaataa ctgtccgttc tccacatgac agccggtgtc ataatgaagg 411661 gattattttc gatatggacg gtgtgaacgt gatttctcat atgaacggga atcattgtga 411721 caggcaaaat agacgcgccg aatccggatg acacgaggct gagcaaagtt gcagagtcgt 411781 ggcattcaca aacaatgcgc ggctccaggt tcaaacgatg aaattcattc atgacctgat 411841 tatagacgcc ttttccgttg acaggccgca gcaggatcag cggaaatgaa ggaatgtcca 411901 ccatcttaat ggtgtctccg cacggatatc cggcttcatc tgaaagcacg agcacacatg 411961 gaatgtcatc aagctgcttg aattgtactg tgtcactttt gatcagtgtt gtcgtgaccg 412021 ccgcatcgat ttgccggctt tccagcagtt ccaacagtgt cgcgggttca ttttcccaaa 412081 tattaaaggt gagatggggg tatctctctt tgatctgtgt tactttttca agcatcagag 412141 ccgcgcaata aatcgttgat cccacggcaa gtgtaccggc tacttcctcc ttcagctcct 412201 gtacctcaat gactgcatct tcaaacctat gcagaatctc ttttgctctt tttagaaaaa 412261 cagctccttc atatgtaaga gtcatttgtt ttttcttgtt acggtcaaac agaacaacac 412321 caagttcgtc ctccagctgt ttgagctgcc tgcttaaagg cggctgcgcc atgtgaagct 412381 ttttggctgc ggacgtaatt ttctgttctt gggcaatggt aatgaagtat cgaagctggc 412441 gaatatccaa aagaaagcgc ctccttatca taccttttag gtattaatta tagatttaat 412501 agatattttt catatggata tatcaggagt atgattgaaa tgaaagcaga attcaagcgt 412561 aaaggagggg gcaaagtgaa actcgttgtc ggaatgacag gggcaacagg ggccattttc 412621 ggggtcaggc tgctgcagtg gctgaaggcc gccggagtgg aaacccatct cgttgtgtct 412681 ccttgggcaa acgtcacgat caaacacgaa acaggctata cgttacaaga agtagaacaa 412741 ctggccacat acacttactc acataaggat caggcggcag ccatttcaag cgggtcgttt 412801 gataccgatg gaatgattgt tgcgccgtgc agcatgaaat ctctcgcaag cattcgcaca 412861 ggaatggcgg ataatctgct gacacgtgcg gcggatgtca tgctcaagga gagaaaaaaa 412921 ctcgtcctct taacgagaga gacgcctttg aaccaaattc atctcgaaaa tatgctagcg 412981 cttacgaaaa tgggcaccat cattcttcct ccgatgccgg cattttataa tcggccgaga 413041 agcttagagg aaatggttga ccatattgtt tttagaacgt tggaccaatt cggcattcgg 413101 cttcctgaag cgaagcgctg gaatgggatt gaaaaacaaa aaggaggagc ttgatcatgg 413161 cttatcaaga tttcagagaa tttctcgctg cccttgaaaa agaaggacag ctgcttacag 413221 tgaatgaaga ggtaaagccg gaaccggatt taggggcctc cgcacgggca gccagcaatc 413281 ttggcgataa aagccctgcg ctcttattta acaacattta cggctatcat aacgcgcgaa 413341 ttgcgatgaa tgtcatcggc tcttggccaa accatgccat gatgctgggc atgccgaaag 413401 acacaccggt aaaagaacag ttttttgaat tcgcaaagcg ttatgaccag tttccgatgc 413461 cggtcaaacg tgaggaaaca gcgccatttc atgaaaatga aatcacagaa gatatcaatt 413521 tgttcgatat actgcctctt ttcagaatta accagggtga tggaggctac tatttagaca 413581 aagcatgtgt catttcccgt gatcttgagg accctgacaa cttcggcaaa caaaatgtcg 413641 gcatttacag aatgcaagtc aaaggaaaag accgccttgg cattcagcct gtcccgcagc 413701 acgatattgc aatccatctg cgccaagctg aagaacgcgg catcaacctt ccggtcacta 413761 ttgcgctcgg ctgtgagccg gtcattacaa cggcggcatc gactccgctt ctctatgatc 413821 aatcagaata cgaaatggca ggtgcgattc aaggcgaacc atatcgcatc gtcaaatcaa 413881 agctgtctga tcttgatgtt ccgtggggcg ctgaagtggt gcttgaaggt gagattattg 413941 ccggagagcg cgaatatgaa gggccgttcg gtgaattcac aggccattat tccggcggac 414001 gcagcatgcc gattatcaaa attaaacgcg tctatcacag aaacaatccg atctttgaac 414061 atttatactt aggcatgcct tggacagaat gcgattacat gatcggcatt aacacatgcg 414121 tgccgcttta tcagcagtta aaagaagcgt atccgaacga aattgtggca gtgaacgcca 414181 tgtacacaca cggtttaatc gcgattgttt ccacaaaaac ccgctatggc ggatttgcga 414241 aagcggtcgg catgcgcgca ctcacaacgc cgcacggact cggctactgc aaaatggtca 414301 tagtcgttga tgaggatgtc gatccattca accttccgca ggtcatgtgg gcgctttcga 414361 ccaaaatgca tccgaaacat gatgcggtca tcattccgga cttatctgtc ctgccgcttg 414421 atccgggatc caatccatca ggaatcactc acaaaatgat tctcgacgcc actacaccgg 414481 ttgcgccgga aacaagaggc cattattcac agccgcttga ttctccgcta acaacgaaag 414541 aatgggaaca aaaactaatg gacttaatga ataaataagg aaaggatgtt cgaaatgcat 414601 acatgtcctc gatgcgactc aaaaaaggga gaagtcatga gcaaatcgcc tgtagaaggc 414661 gcatgggaag tttatcagtg ccaaacatgc ttttttacat ggagatcctg tgaaccggaa 414721 agcattacaa atcccgaaaa atacaatcca gcgtttaaaa ttgatccaaa ggaaacagaa 414781 acagcaattg aagttccggc ggtgccggaa cgaaaggctt gatccgcgtg aactgtatgt 414841 cagaccgtct ctttgagctg cttgacggga gctgcctgaa tgagaagcag catgaggcct 414901 tcgttctgca aacagtatca gaggatggct ggccgcatgc cgctatgatc agtgcaggtg 414961 aaatcatcgc gctgagccga actgatatcc gaatcgctct gtggaaaaac acaatgactt 415021 cggccaacat ccttcgcaca ggaaaagcac agttcacggc gtggtggaag ggagcggcct 415081 attatgtaaa gcttgaatgc gcgcctttac cgcctttgaa agatgccgaa tatgaaagag 415141 accgtttttc ctgccgcatc gtttcagtga aagaggacgt tgcgaaatac gctgatttga 415201 cttcaggtgt ccgtatacag cttcacagcc ctgaagaggt gctgagcaga tggaaaaaga 415261 ccctggaaga tttaaaacgg taatatcgat agcctgacgc catgcgtcag gcttttttta 415321 tataatgaaa acaaaagggg gcgtgagaaa tggaacgtgc ggggatctgt cactcggacg 415381 gctttgattt agcttatcga attgagggcg agggcgcacc catccttgtg atcgggagtg 415441 cggtttacta tccgcgcctt ttttcctcag atatcaaaca gaaatatcaa tgggtctttg 415501 tcgaccatag gggatttgct aagcctaagc gggagcttcg tgcggaggat tcgaggcttg 415561 atgctgtctt ggctgatatc gaaaggatga gaacatttct tcagcttgag gatgttacta 415621 tcctgggaca ttccgggcac gcttttatgg ctttagagta tgccaggaca tatcccaaac 415681 aagttcggaa ggtggcgctc tttaatactg cgcctgataa cagtgaagaa agacagcgaa 415741 aaagcgaatc atttttcatg gaaacagcca gtcttgagag aaagaaacgc tttgaaaaag 415801 acatcgagaa tttgccgcag gacatcgaca aagatcctga aaggcgcttt gtgcacatgt 415861 gtattcgcgc tgaagcgaaa agcttttatc aagagcggcc gcatgctgct gccttatggg 415921 acggtgtatt cacgaatatg ccgatcattg atgaattatg gggcaataca tttgcccgga 415981 ttgatcttct tcagcggtta gctgatgttc gtatgccggt gtatatcgga ttagggagat 416041 atgattattt ggttgcgccc gtttcgctat gggatgctgt tgacggttta tatccccatg 416101 ttgataaggt tatttttgaa aagagcggcc atcagccgat gctggaagaa ccggaagcct 416161 ttgatcaaag cttcaggaaa tggcttgatc aataaaaaac agcccgcaga tcaacatccg 416221 cgggctgttt ctgattataa gacccctttc atcgcgcgtt tgatcaccgg cgagagcagc 416281 aggagaatgc cgccaagaac gatagaaatc aaaccgatgg tgccgaagta cattgtttca 416341 ggaattttat caaacaatcc ggctacttgg gcattgatcg cttgggctgc tgcgttcgtc 416401 agaaaccaca tactcattgt ctgtgcagag aaggcagctg gtgccagttt cgttgtcacg 416461 gataaaccga ctggagacag gcacagctct ccaagcacga caagcaggaa gctgagaacg 416521 agccaaagcg ggcttacgag tgcttctttt ccttgcatag cagggaatac cataatgata 416581 aatgacaatc cggctaaaat aattccgatt gagaatttaa ctggtgtaga cggctgacgt 416641 ttgccaagct tcatccagag ccatgcgaat attggcgcaa aaatgacaac aaacaatgga 416701 tttaatgatt ggaaccatga tgactgaagt tcgaatccgc ccaatgaaag tcttatgcgt 416761 tcatcagcgt ataccgcaag aatggtcgct ccctgttcct gaatggccca gaacatgaca 416821 gcaccgataa acaaaggaac gtaagcggca agacgggatt tttctgtttt gtccgctttt 416881 ttgcttgtaa acatgatgat gaaataaatc acaggaatca aaataccgag aatacttaca 416941 aggtcaatga aacgtttgat cgtcagcacg cctgtttgta cagagataat cactgcgatc 417001 gccacaatga taacaccgat tccggtgcca attgcagatt ttttagacag cggattcggc 417061 acattggaac ctgcaagccc gaggtttttc tttcttgtca aagcaaatac gataagtccg 417121 agaagcattc cgaccgcggc agctccgaat ccgagatgat agttgtactt ctgtccgagt 417181 gttccgacaa ttaacggcgc gagtaaacca ccgaggttaa tccccatgta gaaaatactg 417241 aaacctgagt cgcggcgcgg gtcttctttc gtgtaaagat ccccaactac gcttgaaacg 417301 tttggtttta ataagcctgt tccgacaatg ataagcacca tactgatata gaatgctatc 417361 gaactgcccg gataggcgag tgcaatgtgg ccgaacataa tgaatatgcc gccgtaaaac 417421 acggtgtttg cggtaccgaa tacccggtca gcgagccatc cgccaataat ggtggacatg 417481 tatacgagtg atccgtaaat cgacataatg gcaaccgcag tgcccttgtc aaagccgagc 417541 cctccgttta ccgtctctgt atacaaatag taaagtaaga ttgctctcat tccatagtaa 417601 gagaaacgct cccaaaattc ggtgaaaaat agtgtaaata gtcctcgcgg gtgaccaaag 417661 aacccttttt gcgggacgct tttaatgata ctttcgttat caatcgaagc catgtcagcc 417721 aaaccctttc taaaaaaagt gtattataaa aatcatattc ttatataata cttgtgtcaa 417781 tataatttat actcatttca aatagttcca tattggaaaa attataaata cctaaaaata 417841 gtgatttcct cctaattttt aaacttttta tcgtgagatt ttcttacaca actattcctt 417901 tatatttttt taataaaatt ttagagaaat gtacaagcag atcgggcctt tgtgagtaac 417961 atgatagtaa tcatagagaa ggaggctcgc aattggctga attcatatta aatgcagcgg 418021 atttcggtgt tcctagagat ggtaaaacgg attcgacaga acggattaat cagtgcctca 418081 gtacagctgt ttcgaaaggc tatcatactg tctggtttcc aaagggaaca tatttaatag 418141 acgcaacgct tggcggagat cttaatcaga ggtttcgaaa cgcggggatc attgttcccg 418201 gcaaccttga gattatgatg gaccccgaat gtatcatgaa agtgataccg aatagttcgt 418261 ggggttattc cgcattttat gtaggcaagc aagagaatat aactatttcc ggaggacaaa 418321 ttatcggcga acgggatgag catacgtatg cctcggcggg gataaggtca acccatgaat 418381 ggggctttgg catatgtatt gaaggatgct cgaatgttgt cattgatgat gtgaaaattt 418441 ccgattttac cggcgatggg atcatagtca gcccaagggg attaaagacc aatcaagatt 418501 atcgaacgtc agagcaaatt atcatccgcc gctgtgaggt tcggcggtcg aggagaaata 418561 acatttccat taccggatgt gacatggtca cggtggagga atgcttgatt gaagatgccg 418621 gaacggggaa tggaacagcg ccgaaattcg gaattgacat tgaaggatat ggcgaaggtg 418681 acgttgatta tgaggaaccg attaatgtat caattcgcaa taaccacttt gttggaaacg 418741 tttcaagttc tgtgaccaat tttaacgggt atggcatttt aatagaagga aatcactcag 418801 acaatacaat cagctacgga tatgggacgc aaacagtgat caagggcaat attctgagac 418861 gccctgaaga cgcggcggct gcgccaagag tcgggataac cggactcggt gtatcacaag 418921 gaaaagagac cagtgatgca gtgatcgctg gcaacctcat taccggattt tcaactggaa 418981 ttgatgtcag gggaaagagc gttcttgtga cgaacaacaa aatcagcaac tttgaaaaca 419041 cagggatatt ggtttatcag tcctccgacg taaaggtaga cggaaaccaa attcaaaacg 419101 gactgtctga aacaaggcgc agcatcggtc ttcgcgcagt gctgtcagat gacatcgcat 419161 ttctgaataa ctgtctcatt caagtcgttg acggtgtgaa cgtttccggc ggaaatatga 419221 tcattaaaga taatctcctg agaaaattca gccggggcat ttggattgct caagggaacg 419281 cggtgattga agggaataca ctgaatcctg acgcgtttga agcagtgccg gaatcatatt 419341 ctgtttccgt cacaaacaat gccggcgcca tcatcaaaaa caatacattt aaagagttca 419401 aaaattaccc catttattgc tccacaagtg caaaaacctc aattatcggc aaccacttag 419461 agcgatcccc gcttttggtc accatctata tcagcgcagg tgtgcatgag atttttgata 419521 ataccatttc agtcaacaga acagccggga atccgattgt gatttatctc aatggctctg 419581 caggctctat catctctgga aacaccatca ataacctctc cgcgggcact gcgacagcta 419641 ttcaaacaaa cacgtcaacc aattccaaaa tcatcggcaa ccgcattttt aaagggacca 419701 tcaacaaaca cagcagtgat acaatagacg gcaatatgat tgtctgaaaa aagcgccccc 419761 ctttaggggt tctttttttt cgatttatag atcacgtaca tttctctcac aagtactaac 419821 acaaaaaata aaagcacgac ccattccgca aatgttgtca tcttaaagct ggacatattg 419881 ttataaacgg cttttgttaa actgaaccct tgaagcatgt ccatcaacac agaaatagct 419941 aataaacaaa ttaatatgaa tccggtcacg cccaatatct tcatgcttca tcatcctccg 420001 cttttagtgt ctatctttgg cggagaagtt ataccgcatc taaccctaat gcataatctc 420061 aattttaaaa ggaagaatat gagaaaacga caaggaaagg tatttgtgta tgcctttatt 420121 ttctaagcga aagaacaata ccgattcaaa agacaagcag aatacagacg aaaggaatca 420181 ggaacagcag caagaaaaag aaaggccggt tctcatttct ccaagtttag caaagaatat 420241 agcggaaacg aaaaaggaag tcggaagcag ctctgacgtc atcattcgcg agattaaaat 420301 cggggagcag gatcatgtcc acctagctgt tatctatatt tctgggctgg tcgataataa 420361 cacgatccat gagtcgttaa ttgacccatt ggtacaggat gagtctatcc agaatactca 420421 tgcgatccag caaattcttg aaaaaacgct cccgctgggc ggggtgaaag cggaaaagag 420481 ctgggacaag cttttttccg agttaatgct tggcaatgcg ctcatttttg ctgatggcca 420541 tgatgaagct ttgatttgca gcactcaagg gggagagcag cgctccatcc aagagccgag 420601 cacccaggtg tcattccgcg gcccgcgcca agggtttaca gagtctctgc aaaccaatat 420661 ttccatgatc cggcgataca ttaaaaatcc gaatttatgg gttgaaaaaa tgaaaaaagg 420721 ttctgttacg aatacggata tcgctctcat gtacattcaa ggaatatgtg atgaaaaggt 420781 gctgaaggaa gtgaaacagc gcctggaaaa aatagatatt gacagtattt tggaatctgg 420841 atatattgag cagctgattg aagatgaaac ctttacgacg tttccgacta tgtatcatac 420901 agaacgccct gatgttgtag cgggtaatct gttagaagga agattcgcga ttattgtgga 420961 cggaacaccg tttgtgctta ttgccccagc cttatttgtc cagttttttc agtctgttga 421021 ggattattat tcgcgttttg acattgcgac aagcataaga attcttcgtg ttttagtctt 421081 tttcatttcg cttgtggcac cagctgtata cgtggcagcc acgacgtttc atcaagaaat 421141 gataccgact cagctgttag tggtcattgc ggcccagcgg gaaattgtcc cgtttccggc 421201 tgttgtggag gcgctgacga tggaggttgc ttttgagatt ctgagggaag cgggagtcag 421261 gctgccccgg gttgtcggct cggcagtgtc aatcgtaggc gcgctcgtaa tcggccaggc 421321 tgccgtacag gctggtatcg tctctccggc aatggtgatt atcgtggcac tcaccgcgat 421381 tgcgagcttc gcaacaccgg cgtttgcaat ggcgatttca gcccggctta ttcggtttat 421441 ctttattatt gcctcagctg ttatgggttt ttacgggctg attttaggga tcattatgat 421501 gtttgtccac ttatgcagtc ttcgttcatt cggcgttcca tatatgtcgc cgcttgcacc 421561 tttttcttca caaggcgtaa aggacgcgct tttccgggtt ccgtggtggg ccgatgaaaa 421621 aaggccggaa tcggtcagca aggaagataa ggtgcggcag gggaaagatc aacgcccaga 421681 gccggccgct tcacgaggaa tggtgaacaa agatttggaa gaaggggatc agaatggtac 421741 gtaaatgtct attagccgtt ctcatgcttt tgagcgtcat tgtgctgccc ggctgctggg 421801 ataagcggga gctgacggat cttgcgatta tctcggcgat tggcatcgat cggacaaacg 421861 acagcaacta cgtgctgcat cttcaaatta tcaatccagg aaatgttgcc ggcggccttc 421921 agggaggcgg tgctggagac aggccgcctg tatctgtcta ttcgattgaa ggtaacaata 421981 taacggaagc actcagaaaa gcctccatga aggtatcacg gcggctttat tttgcccata 422041 ccaatctagt cgtgatcaat gaaaagctgg caaaagaaga aggtttggat tttgtattag 422101 ataatcttga ccgggacaca gaattcagga caacagcaac attcgtcgtt gcccataaaa 422161 caaaagcaga aaatattgtg aaaatcttga cgccgattga taaaattccg tcaaataaag 422221 tcaataaaac actcgatttc acggaggcac aatacgggcg ggtggtcaaa atcaatattc 422281 aggacgtttt gaaaacactt gccgccaaca ctatggcacc ggtcatcccc ggatatatga 422341 tgattggtga cgataaaaaa ggagtcagca tggaaaacac gcaggcgact gacccgaaag 422401 ccattcttca ggcagatggt ttggcggttt ttgataaggc aggatattta aagtattggc 422461 tggaagatga tgaaagcgtg ggggcagtct ggcttatgaa taagatccag catacgttta 422521 ttaatgctga ctggggcaag acgaaggatg cggtcagctt gcaggttacc catcaagata 422581 caaagctggt accgaaaatg cggaacggac gcccgtacat ccatgtgaaa gtgtcggttg 422641 aaggtattat agatgctgtc aaataccctt tccaattgtc tgatcccaag gtgctggccg 422701 ctattgaaaa agcgctcaac aaagagcttg aaaaggaaat cagccatact gtgaaaaaga 422761 ttaagaagaa taaaatagat tttatcggtt ttggtgacac gatatataga aagtatccgg 422821 agcagtggga gaaaatgaag gacacttggg acaaagaata tttgccggaa ctgcccatcg 422881 atgtgaaggc cgagacgtat atcagaagga cgggattgcg aaacaatccg atcaaacacc 422941 agtttaaaga tgattaggtc tgaagaaagg ggaagtgaca gatggaaaaa gccagaataa 423001 gcataaggca gttgtttgtc atgattatca tttttgaact gggcagctcc ttattgatta 423061 caccgggatc aatggcgggc agggatgctt ggatagcagt tttattaggc tgtgcgatcg 423121 gactgtttct tttctatttg tatcaaggca tttatcaatg ttatccgaat tcttctccga 423181 aagaatatat ggatgatatg ctgggaacca agctgagctg gctgttttca tttctctata 423241 tcttgtactt tgcctatatt gccgcaaggg tgctgcgtga ctttggagaa atgctgctga 423301 cgtttgctta tcatgataca cctatcatta ttgtaaatgc tttattaatg gtagtaagca 423361 tatatgccgt aagaaaagga attgaagtac tcgcacgcgc ggccgaactt cttttcgggg 423421 ccatgtattt actgggcgcg atcggccttg tgctgattat tgtctcaggg actatagacc 423481 cgcacaattt aaagccggtt ttggcaaacg gcatttctcc tgtccttcac tctgttttca 423541 cacagaccat gtacgttcca tttggtgaag ttgttttatt tgtgatgatt ttccctaacc 423601 tgaatgacag aaaagatgtg aaaaaaatgg ggatgatcgc catggctatt agcggattga 423661 ttgtggcgct caccgtggcg attaatatta gcgtgcttga tgttgatctt acactcagat 423721 cccagtttcc gcttttaagc acgatccaga caatcaaggt cgaagaattt ttagaccggc 423781 tcgatgtctt ttttatgctg gcgctgatca tcggcggctt ctttaaggtc agcctctact 423841 tatatgccac tgtggttggg acatctacgc tctttaagga aaagaacccc tctcaattgg 423901 cttatccgat gggattgggc atcttaatcc tttctataac gatcgcgact aacttttcgg 423961 agcacttgaa tgaaggcctg aacgtggtgc cgctgtatat tcatttgcct tttcaattat 424021 tgtttccgct ctttctgttt attgtggccg tttggaaaaa gaaacgaaga gagaagtcaa 424081 aaggggagga agcaaaaaaa tgataaaaag agcgggggga tgcggccgcc gctcttttta 424141 tgttcacttc tatataaaag ggggatatag ggtgcgcccc tgtctgcact ggcagaggcg 424201 cgttttgtta tacgactgcg acgttttcct tcacagtaaa acttcctctt gaaagtctga 424261 tattgatgtc tgacactttt gcaatttgtt catcgtgcgt caccataatg acgcatttat 424321 cttccttgtg cgccagatcc tgaaagagcc gtacgatctc ttttgatgtg tcctcatcaa 424381 ggtttccggt cggttcatcg gctacgataa gatccgtgtc acagcagaaa gcccttgtaa 424441 ttgatacccg ctgctgctgt ccgccgctca gtgtgagcac tttttgccgg gcttgttttt 424501 cgttgatgcc aaccttctgc agcatgtcaa gcgcatatga ttctttgttc ttttctttag 424561 aacctgtgat ttccatagcg gttgtgacgt tctgcaaagc cgtcatatac gggagcaggt 424621 tgtacgcctg aaagacgatt gatacatatt gatttctgaa attggttaag ccgattttag 424681 aaaccgcttt tccgtcgtaa aggatgtttc cttcttttgg tgcgtcaagt ccgcctgcca 424741 gagacaggaa agtggttttc cccgtccctg atgttccgac gattgtgtag aattttcctt 424801 tttgaaagct gatgttaata tcctgaaaca atggctggct tttgttttta taccagtagc 424861 cgacttgttg aaattgtaat aagctcatag gttccgcctc tttctattcc tgttttgtca 424921 atatcgtttt cggatgaagc cgcagtactg aaattgacgg cagcaatgtt gcaatgattg 424981 cgattaggat gccgatcccg ccaagtataa gcatgtcgtt catagaaacc gcgacgttca 425041 gtgaatcgat aacgtccacg ttggatgaac tgtggccgaa cattttgccg cccatgccgc 425101 caccgccgcc gggcatttgt ccgcttgcgg tttgcgttga atcggttgat gaactgattt 425161 gctgggataa aagctgattt ccaagctgat tcgcgacgag atttcccgtc acagatgcaa 425221 ggccgatagc gataacggcc acaatcagaa tctcagtcaa gaactgtcca atcaatttcc 425281 atcgtttttc accgatggcc attaacacgc ccatttcgta tttgcgctcc ctgattgaca 425341 tcatgacaat caggccaaga atgacggcgc ctgccactga tacaagatac accacgtttt 425401 tagagaaaga agccacattt tcaatcggtc cgaccatttg ctggtaaagc tgatcgtttg 425461 tattcagtgt gtacgtatca aagtcaattg atgttttctt cgctgctttt acgaaagtat 425521 ccatattttt cgcgtcgtcc atatagtaaa cagctgagtc aatcgtattt ttatagtcgt 425581 cgcctttcaa tgccgctgtt gctgtgtaag gcgtataaag cttgttataa ggatttaaga 425641 aagagaaatt ttgggcttgg tcatcacctg aagatgttgt tttataaata ccgacgatct 425701 tcagttttac tgttgtatcc tcatccgttg ctgattcaat tgtgatcgaa tcgccaacgc 425761 ttaaatcatt ttcttccgct aatgtttcgt tgatcactgt tacttttttg ccgacatctg 425821 attttgtaat cgcgcgtccg tctgtgattt ttgaatctcc gtcagagaaa tcatcgacta 425881 acgctgtgct gatgacacct tcaatagaaa gatcagcttg aaccatttgc ggtccgcctt 425941 gtcctccgcc ttgactgttt ttagcgtttg agcttgaact gctggagctg gaatcacttg 426001 aactagagct ttcaatcgca tcaaagtttc ccgcgttggc tgaagctgat gtggtgtaat 426061 tgtagctctt cacatgatca agcgctgcaa gcttattcgc atcagacact ttgatcggtg 426121 tggattcgaa gctgcgcttt tcaccgctgt cctgctgttt ttccatttgc ttttggcggt 426181 caacctgaag tgtcacgctt ccaccgagtt cctgtctggc cagttcgctt gacttttgtg 426241 ctgccgactg gatggcgagg cctgatagaa caaagacaca tatgactgta aacacaaata 426301 attgcaataa cgtttttccc tttttagcct tcatattcca aaaggcccgt ttgataaagt 426361 tcatttatgt tcctccgtat aggtattttt attgataaga ccgcctctgg ggcgcgtccc 426421 cttgctgata aattaatagt agtccaaagg tatgaaaaaa atatgaacaa tctatttcta 426481 gttgatgaaa taaaaactaa caattgtgaa acgcaaaacc ttctgtttaa aatggtgcta 426541 ttatataaaa aagcatcaaa acaaccggag gatataatga aaatattaat gatagaagat 426601 aatgttagtg tatgtacgat gacggagatg ttctttttta aagaaggttt tgaagccgaa 426661 ttcgttcatg acgggttaga agggtaccag cgttttacgg aagaaaattg ggatctaatc 426721 attttggata tcatgcttcc atctatggac ggcgtgacca tctgcagaaa aataagagag 426781 acaagcacgg tgccgattat catgctgact gccaaagaca ctgaatcaga tcaggtcatc 426841 ggttttgaga tgggggcgga cgattatgtc acaaagccgt tcagcccgct gacattggtt 426901 gcccgcatca aagccgtcat cagaagatat aaggcgacag gcaaagcggt tattgatgaa 426961 gatatgattg aaacggaatg ctttaccatt aataagaaga cgagagaagt attattaaac 427021 ggagagcctg tagaaaatct cacgccgaag gaattcgatc tgctttatta ccttgtccaa 427081 aatccgcggc aggtgttctc cagagaacag ctgcttgagc aggtatgggg ctatcaattt 427141 tatggagatg agcgaacggt tgacgttcat atcaaacggc tgcggaaaaa gcttgccagc 427201 gaggacaagc ctttcctgta tactgtgtgg ggagtagggt ataaatttga tgaagattaa 427261 atatttatat cagctgctgc taagccatat cagcattttg attttagcgt ttgtcattat 427321 catttctctg ttttcccact ttgtgaagga atttgcctat cagaacaaag tagaggaatt 427381 gacgtcatat gcggtgcaga ttgcaaatga attccaatcc ggccaggtgg acatgcgcag 427441 gctctatcct tatcaggaca ttttaagcac aagaaagacg caatttatca tctttaatga 427501 agagcagcag ccttattttc ttcctgaagg ctttcatcac ccaccaaggg aacagctgaa 427561 gaaatcagaa tggaataagc tgaaaaaagg gcagactgtc acgatcaggg cagatggccg 427621 ttttgatgat gaagtgtccc ttgtggcgca gcctatattt gttcagaacg aatttaaagg 427681 cgccgttctg ctgatttctc cgatcagcgg tgttgaacag atggtcaatc aggtcaacct 427741 ctatatgttt tacgctgtga tcagcacgct tgtgattacg attcttgtga gctggcttct 427801 gtccaaattc catgtcaagc ggattcaaaa gctgagagaa gcgacagata aagtggcttc 427861 cggcgattat gacatccatt tggaaaacag ctacggggac gaaatcggcg tactggcgtc 427921 tgactttaat atcatggcga aaaaactaaa gcagtcaagg gatgaaatcg agcgccttga 427981 gaagcggaga aggcagttta tcgctgacgt gtcacatgaa ttaaaaacac cgctgacgac 428041 gatcaacggt ttggttgaag ggttgaacag ccatacgatt cctgaggata aaaaggataa 428101 atgcttctcg ctgatcagtg aggaaacgaa gcgcatgctg cggctcgtaa aagaaaatct 428161 ggattatgaa aaaatcagat cccagcaaat taccttgaac aagctagacg ttcctctgat 428221 cgaggtgttt gaaatcgtga aagagcactt gcagcagcag gcggaagaaa aacaaaacaa 428281 gctgatgatc caagtagagg atcacgtcat cgtacatgcc gattatgacc ggttcattca 428341 aattctcgtc aacattacga aaaacagcat ccaatttacg caaaacggtg acatttggct 428401 gcgcggaatg gaaggttata aagagacgat tattgaaatt gaagacacgg gtatcggcat 428461 tccaaaagag gatattgagc atatttggga gcgattctat aaagcagata tttcaagaac 428521 gaacacagca tacggtgaat acggactcgg tctctcgatc gtcaggcagc tcgttgaaat 428581 gcaccagggc acagtagaaa tcaagagtga agaagggaaa ggcacaaagt tcatcatccg 428641 ccttccttta acggcaaaac agcaatagca tacagggcgg cgcatcaact gatgcatccg 428701 ccttttttgc acaccgcttc ggtttattgc gtgctcccga aaacaaagat tgcgtgtttt 428761 tcgggttggg acggcctata aacatgataa aatatgacat aaacagtttt tgatgggaga 428821 gggtgaagga atgaagagtg gggtaattcc ttcttcagcg gtcggtcaaa aaattaacga 428881 gtggtacaga tatatccgga cattcagcgt gccggatgcc gaagtgttaa aagctgaaat 428941 ccagcaggaa ctgaaacaca tgcagcatga ttccaacttg ctgctttatt attcactaat 429001 ggaattccgg caccagctta tgctggatta tcttgagccg ttagagaaat taaatatcga 429061 agaccagcca agcctgtctg aattatcaag aaacattgac agcaaccagg cagatctcaa 429121 agggctgctc gactattacg tgaatttttt tcgcgggatg tatgaatttg ataagcggga 429181 atttatttct gccattacat actataaaca ggcggagaaa aagctctcct ttgtcgcaga 429241 ccatattgaa cgggctgaat tctattttaa aatcgcggaa gcttattatt atatgaagca 429301 aacgtatttt tcattgatta atataaaaaa cgcctatgaa atttacgtgg agcaggaaac 429361 ctataatgtg agaatcattc agtgccattt cgtcttcggg gtcaacctga tggatgaaag 429421 aaatttcgaa caagccgcac gccatttcaa attggcgctc aacatggccc aagcagaaca 429481 aaaagcccag ctggttggaa gagcatacta caatctcggg ttatgctatt acaatcaaga 429541 ccttctagac cctgccattg attactttga aaaagcggtc tccacatttg aaagcagcag 429601 gatcgtcaat tctctcccgc aagcctattt tttaatcacc ctgatttatt ataaacaggg 429661 aaaacatgat aaagcttcgg aatatcacaa gcggggctat gaatatgcta aagaaacaga 429721 cgatgcagac tatgccgtaa aattcgagtt tttgcaatcc ctatatctgg atcagcccaa 429781 tgaagaagga atcgaacgat gtttccagta cttaaaaaat aaaaatatgt acgctgatat 429841 agaggattta gccctagaag tagcaaaata ttactatgaa cagaaatggt ttaaactgtc 429901 tgcttcctac tttctacaag ttgaagaggc aagaaaacaa atacaaagga gtgaaggttt 429961 gtatgaaatt gaaatctaag ttgtttgtta tttgtttggc cgcagccgcg atttttacag 430021 cggctggcgt ttctgctaat gcggaagcac tcgactttca tgtgacagaa agaggaatga 430081 cgtaagaaca agccccttct cattagcgag aaggggtttt tcttttcaaa aaaacaccgc 430141 aagacatagt cttgcggtgc cgccttcatg gagattacgt ttatttagta gcctcctaca 430201 aatgcagttc ccacaatgat caagaggata aataacacaa caatcaaagc gaaagaagtt 430261 ccgtaacctg acattttgtg cacctccttg cgagattgct tcagcaaatg ctgcaaaact 430321 gtggcggaca gggtcccgca gagacggtca gcagcttaga agccgccaac aaacgcagtc 430381 cctacgataa ttaatagaat aaacaataca acgattaaag cgaaagaact gatgccgccg 430441 taaccgccgc cgttagagta tcctgacata aggtttcacc tccctatgaa ggatactata 430501 agatatgctg aaccgatcca tttggcaggg ataatagtgg acaagagaaa aaatgaagaa 430561 ttcggctata tgaaggtgat ataaaaaaat agcgggcgct gccgcccgct atttatgtac 430621 gattaagaga tcagcacgcc cgcgaaaaat tcctggtata acgcttgaac ggcttttctt 430681 tcttcggctt cttttacgcc aaacatcatg ctcacttcag aagacccctg attgatcatt 430741 tcgatattca cctgtgcctc tgataatgct ttggcggctc ttgccgttgt accgacattg 430801 tggcgcatcg cttcccctac aaccataatc agggcgagat gatgctcgac gatgacttca 430861 tcggcatgca aatcctcttc gatccgtttg atgacgctgc gttcagtggc ggcatccatt 430921 tgcccctgcc gtaaaatgat tgtcatgtca tcgattcccg atggaacatg ctcatacgtc 430981 aaaccatgct cctccaggat ttgaagggct ctgcggccaa aaccgatttc tctgttcatg 431041 agatacttgc tgatataaat gctgcaaaaa ccggtgtcgc tggcaatgcc gacgacaggc 431101 ccgtttgtgt tatcccgctt gctgacgacg cgggtgcctt cggctgaggg gttgttcgta 431161 tttttgatct gaacaggaat ccccgctctg aatgccggaa tgagcgcttc atcatgaaac 431221 actgaaaaac ccgcgtagga cagctcccgc atctctctat atgtcagctc gctgatttcc 431281 tttggattct caacgaagga cggattgaca gaatacacag cgtctacgtc tgtaaagttt 431341 tcgtacaaat cggcttgtag tccgttggca agaatcgaac cggtaatatc agaaccgctc 431401 cgtgagaatg tgatcacatc gccatccttg ctgaatccga aaaaaccggg aaaaatgatg 431461 agtccgtcac gttcccgaag acgatagagg ttttgatagg attcaggaag aacttgcgcg 431521 ttgccgggtt catttgtcac aaagaggccg gcatccttcg ggtttacata ttccgctttg 431581 acgcctttat aacggaagta agcggcgatc agtttggcat tgttatcctc tccgctggcc 431641 ttgactgcgt caaggtattg ttcgggattg cttttgtctc cttctaaaag cgtaaacaga 431701 tcatctctga ttttttcgat aatgctttgc cccagctgaa gctcattggc gatgagagcg 431761 taccgttcca caacagcttc cgccagttca ggtgcgctgc ctgttgccaa atattgttct 431821 gcacatgcga ttaagagatc agtcactttc gtatcctcgg catagtgttt tcccggagct 431881 gaaacgacta cagctttccg tgccggatct gaggtaacga tgtgaaacac cttgtcaagc 431941 tgggcgcctg aagcaagtga gctgcctccg aatttaacga ccttcatgtt tacatctcct 432001 aatgtttaaa attttcacac aaatttagta tttattatct ctctttcagt actgtaaatc 432061 aagggggaat ttctttctca ggagaacatt tgtatttttc acgaggaata atgttaggtt 432121 tgctgaccgt atgcctgcgt tataaagata aatatggtaa acagcctaac gttttgggat 432181 ggaaaatggt tagaatgatt agtaaaattg ataaatgact aggttaatat ttttaaagaa 432241 tattgactaa ccctataaaa atggtaatat gtaaatgata atgataatca attactatat 432301 ggccatattg ttttgagtcc ttgcggagta ggagatacgt tctttttgct gtaaggatgt 432361 aaggaggcag catgaagcta cgttacttat ttattctact tatcatatta gcagtcacat 432421 ctgtatttat cggtgtagaa gatctgtcgc cgcttgatct cttcgattta agcaaacaag 432481 aggcgtcaac gctgtttgca agccgtttgc cgcgattgat cagcattgtc attgcgggat 432541 taagcatgag catctgcggt ttgattatgc agcagatcag cagaaataaa ttcgtgtcac 432601 cgacgacggc gggcacgatg gattgggcga ggctcggcat tttaatttcc ttgctgctgt 432661 ttacatccgc cagtccttta atcaaaatgc tggtcgcgtt tgtctttgcc cttgcaggaa 432721 attttctgtt tatgaaaatc cttgaaagaa tcaagtttaa cgacaccatc tttattccgc 432781 ttgtcggttt aatgctcggg aatatcgtca gttcaatcgc gacatttatc gcatataaat 432841 atgacttgat ccagaatgtg tcatcatggc tgcagggaga cttctcttta gtcgtgaaag 432901 gaagatacga gcttctttat ctgagtattc cgctcgtcat cattgcctat gtgtatgcgg 432961 ataaattcac attggccggt atgggtgaaa gcttttctgt caacctcggc ctcaagtata 433021 aacgggttgt gaacatcggg ctcattatcg tgtccctgat cacgtctctt gtcattttga 433081 ctgtcggtat gctgccgttt ctcggtttaa tcatcccgaa tattgtatcg atttacagag 433141 gagacaatct gaagagcagc ctgccgcata ctgtgctgtt gggagcggtt tttgtgctgt 433201 tttgcgatat actgggcaga atcattatct tcccttatga aatctcgatt ggcctgatgg 433261 tcggaatcat cggcagcggc attttcctgt ttatgctgtt aaggagaaaa gcctatgcgt 433321 aaccagatga aaatagcttt gctcgttggt ttagccattg tatgtattgg cttgtttttg 433381 ttttatgact taggcaattg ggattacacc ctgccgagac gaatcaaaaa agtcgctgcc 433441 attgtgctga ctgggggagc gattgcgttt tcgaccatga tctttcaaac gattacgaac 433501 aaccgcatcc tgacgccgag cattttgggc cttgattctc tctacatgct gattcagact 433561 ggcattatct ttttgttcgg ttctgcgaat atggtcatca tgaataaaaa catcaacttt 433621 atcatctctg ttctgctgat gatcctgttt tctcttgttt tgtatcagat catgttcaag 433681 ggtgagggga gaaatatctt tttccttctg cttatcggaa tcgtgtttgg cacgctgttc 433741 agcagcctgt cttcttttat gcagatgctg attgatccga acgagttcca agttgtgcag 433801 gacaagatgt ttgccagctt taacaatatc aatacggatt tgttatggct cgcgttcatc 433861 atcttcctgc tgacaggcgt ttatgtctgg cgttttacaa aatttttcga tgtgctgtcg 433921 ctcggacgcg agcacgccgt gaatttgggc attgactacg acaaagtggt gaagcagatg 433981 ctgatcgtgg ttgcgatttt ggtttctgtt tcaacagcgc tagtcgggcc gattatgttt 434041 ttaggccttc tggtcgtcaa cctggcgaga gaattcctga aaacatataa gcattcatac 434101 ttaatcgcag gctccgtttt catcagcatc attgcgctgg tcggagggca gtttgtggtt 434161 gagaaagtgt ttaccttctc aacgacgctg agcgtcatta ttaattttgc cggcgggatt 434221 tattttatct acttgctgtt aaaggagaat aaatcatggt agaggtcaga aatgtaagca 434281 aacaatatgg cgggaaagtt gttcttgaag agacgtcagt cacgattcaa aagggcaaaa 434341 tcacctcgtt tatcggtcct aacggcgccg gcaaaagtac gctgctgtct atcatgagcc 434401 gcctgatcaa aaaggattcc ggcgagattt acatagacgg acaagagatt ggagcatgtg 434461 acagcaaaga gcttgccaag aaaatgagca ttttgaagca ggcgaaccaa atcaatatca 434521 ggctcacgat caaagacctc gtcagttttg gcaggtttcc gtactcacag ggccggctga 434581 cagaggaaga ctgggttcat atcaaccagg cgcttagcta tatgaagctg gaagacattc 434641 aagacaaata cttggatcag ctgagcggcg gacagtgcca aagggcattt atcgccatgg 434701 tcattgccca ggacacagat tatatctttc tggatgaacc gctgaacaat ctggatatga 434761 aacactcagt tgaaattatg aaactgctga aacggctggt agaggagctt ggaaaaacga 434821 tcgtgatcgt cattcacgat atcaattttg cttcagtcta ttctgactat atcgtcgctt 434881 tgaaaaacgg ccgaatcgtt aaagaaggac cgcctgaaga aatgatagaa acatcagtgc 434941 ttgaggaaat ctacgatatg accatcccga ttcagacgat tgataatcaa agaataggtg 435001 tttatttttc ttaatatata gaagaggtga ggagcatgaa aaagttcgcg ttactattca 435061 tcgctttggt cactgccgtt gtcatttctg catgcggaaa ccaaagcaca agcagcaaag 435121 gttctgatac aaagaaagaa caaatcacag tgaaacacca gctcgacaaa aacggcacaa 435181 aagtaccgaa gaaccctaaa aaagttgtcg tatttgactt tggaagctta gatacattag 435241 ataaactagg acttgatgat atagtagcgg gcctgccgaa acaagtcctt cctaaatatc 435301 tgtccaaatt caaggatgac aaatacgctg atgtcggcag cttaaaagag ccagacttcg 435361 acaaagtggc agaattagat cctgatctga tcattatttc agcaagacaa tctgagtctt 435421 acaaagaatt ctctaaaatt gcgccgacga tttaccttgg tgtagataca gcgaagtaca 435481 tggaatcatt taaatcagac gctgaaacaa tcggtaaaat ctttgataaa gaagacaaag 435541 tgaaagatga gctcgcaaac attgatcact caatcgcaga tgtaaagaaa accgctgaaa 435601 agcttaacaa aaacggtctc gtcatcatgg cgaacgatgg aaaaatcagc gcgttcggcc 435661 ctaaatcaag atacggcctg atccatgacg tattcggcgt ggctccggct gatcaaaaca 435721 tcaaagcgtc tacgcacgga caaagtgttt cttacgagta catttcaaaa acaaaccctg 435781 attacttgtt tgttattgac cgcggtacag caatcggaga aacatcatct acaaaacaag 435841 tcgtggaaaa cgattatgtg aaaaacgtaa acgcagtgaa aaatggtcat gtcatctacc 435901 ttgattctgc tacttggtat ttatcaggag gcggacttga gtctatgacg caaatgatta 435961 aagaagtgaa agacggttta gaaaagtaaa accaaaaaga gcctccgcta aatagcgggg 436021 ctcttttttt gttaatcagc gtgccggctg ctgttcggca gggcgctgag gtttctttaa 436081 tgtgaatgag agaaggaagc cgacaagtgc aatgacggca gccactataa aagcggcgtt 436141 catgccgtgc agggcggcgt gcttcacatt tgtcgtgcct gcatgtgccg cctggttgct 436201 catcacggaa accaatagtg cggttccgat cgagccgccg acttggcgaa tcgtgttgtt 436261 catcgcagtt ccgtgcggaa tcaagtggcg cggcagcgca ttgattccgg ctgttgtcac 436321 cggcatcatg atcatggcgg tgcctaagag acgaacggtg tataaaacga caatccaagc 436381 gagtgacgta tggtcagtca gctgcataaa cggcagagat gtcaggaaga tgatgcagaa 436441 accggcaatc gccagccctc ttccgccgac acggtcaaaa attctgccga taatcggcga 436501 cataaagccc atcacaacgg ctcccggcag gagcataagc cctgtatcaa aagctgtgac 436561 gtctctgaca ttttgtgtat aaagcggcag gatggtttcc gtaccgatca ataatgcaaa 436621 gacgagggtt cccagcagtg ttgttaagct gaaaacgcca aacgtgaaga cgcggaattc 436681 cagcatcggt tttttaagct tcatttgtct tgtgataaac aagagcagcg cgatgacacc 436741 caccagcagt gaaatcaaga cggttgaact ggaccagcca taagagccga cgcttgagaa 436801 gccgtacaga aggccgccga acccaaatgt tgaaaggatg actgataaaa tatcaatctg 436861 tgtttttctt aaagtcgtca cgtttttcat caggatgctg gcaagaatca aatcaatcac 436921 agcaaacgga agaataatat aaaacaatga tctccaagag aaagcttcga cagcccatcc 436981 ggaaagagtc ggtccgatcg caggcgcgaa tgagatgacc aatccgacca tacccatagc 437041 ctggccgcgc ttttcaatcg gaaagattgt caggaataca gtctgcatga gcggcatcat 437101 aatgccggct ccagccgctt gaatgatacg cgctgtcagc agaaccggga agttcggcgc 437161 gaacgctccg acgactgttc cggcagtgaa aatgctcatt gctgtgatga gcagcgcccg 437221 gcttgtgaat ttctcaatta aaaacgcggt aatcggaatt aaaatcccgt tggttaacat 437281 aaatgatgtt gtcagccatt gtgcttggtt ggcatcgaca ttgaaatccc tcatgatatg 437341 gggaagtgca gtaatcaaca atgtctggtt caaaatcgcc acaaacgctc cggctaacaa 437401 aatgccgaca atgacagaac ggttaaaagg tttttgttca atacttgtgt tcaatacata 437461 tcccttcttt tctctaagta attaacagtg tttttaacat ggaaacgggc tgtgttaaaa 437521 caccggtttg ttccagatag ccaatcagtg atttgagtaa aaaagcgcgg ggttcttcct 437581 tcttcgcttc ttcctccagc atagcggctg cggatgtcag ttcatctacg tcatagtccg 437641 cggcggacag ggaagagatg cctttatgta attccttcag gctttccgat aataggactg 437701 atttatcctt tggcttgtag gaggatgctg aatgaatata aagctcgatg gcttcgggcg 437761 gaagaagaga ctggcgggtt tccctgtttt tgataatctg attgagggtg ctgatgataa 437821 actctgcgat cgggtcaagc tcaagcggtt tttcctcgat tttgatcagc attaaaaact 437881 cacgcatcat gccgtgaaga atgataacca aatcccacac aaacgggaga atggtttctc 437941 catacgcctg gatcagcgaa tcgcggtgcc agcagataat cgtcgatctg gtctgatgga 438001 tatgctgttt gacccggtca ttgtgcagct tggggtttcc gtaggtcagc atattgaaaa 438061 actgctgatt ccgcctgaag ccctccagtt ccattttgac cttttgcgtc aaacgctcct 438121 ccggtgtaag tgctgtattt tcctgaagtc ttgaggccgc ggccaccatt tgcttctggt 438181 taaatgacag cagctccaaa agcagatctt ctttagattg gaacagctta tatatcgaag 438241 cttttgacat cttacattct tctgcgatcg cctgcatgga aaccgacgta aaatcctttt 438301 ccgaaaaaag ctttcgcgcg gctaacaaga tatctgtttt tttatcaagc atctcatggc 438361 ttccttcttt cttgaacatt agaaaaccca ttggttcaca gaaaaccaat gagtaacaat 438421 gaaaaaattt taccagataa acaaaataga agtcaatgga ttttaaccgg gtaaatgaaa 438481 ggcctgccgg aaaatccgac aggccgaata agagcttatt tttcaacttt aaatccttgt 438541 ttttcaagca tttcacggat gtgcggatag tacaggcgct catagtagga agcgatgctc 438601 tgtgaccagt ttcttgtttc ttttccgttt gtccgtttat tcatgtattc agacatctgt 438661 tcgtcgtatg cctgaatgtg agacgtcagc tcatcctgat tcaaataagt ttcctgatga 438721 ttgacagctt cctgcggcaa gcgcggtttt ttcgctgaac ggtcggcagg atgcccaatg 438781 acaaggccgg ataaagggaa cacgtatttc ggaagctcaa gcagttcgat cagctcttga 438841 gggtttccgc gaactgcacc gatcggaact gtgccaagtc cgagtgactc agccgctgct 438901 gttgctgtgc cgagggcaat accagcgtct actgcgccga caagaacaga ttccaatcca 438961 tttgtgattt ccattttgaa atcatgcaga tcttcaagcg caattttggc ccggttaaaa 439021 tctgcgcaga acagcaggaa aacaggagct tgatcgatcc atggctggcc gcctgccagc 439081 tcggagattt tctttttgcg ctctttatcc tggactgtga tcacagtcac ttgctgtccg 439141 ttgatagaag aaggggctga ttgcaccgct tcaatgattt ggtccaattg ctcctgagct 439201 acaggctcat ctgtgtagct gcgaatcgag cggtggtctg ttaaagattt aatcacttca 439261 ttcatatgag acacccttcc tttactcgct aagctctgtg cggacaacat caagaggagc 439321 gctcagcagt tcttttcctt ttgcgacaaa cccttggaaa tgcgcagttt cgttatggaa 439381 tttcattgcc gcttcatctt tccatttttc aagcatgaca aatgtatttt cttcgcctac 439441 tttttcgaat aggtcgtatt gcgcgttgcc ttcctcagct cttgaatgct gaacaagtga 439501 ttgagcctcg ctcaaaaatt cctcgcgttt ttctggtttt actttgatgt aagcttgtaa 439561 tacgatcatg taaatctcct ccgtcgttat gcgaatttat tgttcgaatt tcatcgaact 439621 aaatgtaaca tgtattctaa atgaggtaaa ggaaaaaccc ttatatagta aaattgtcat 439681 tctaattgtt gtatgataca tttgtgtcat gaacattcca aaccatccag aaacagaaac 439741 attgcagctg acaaaggttc ttcatgcact tagtgatccg cttcgtttag agctcgtcaa 439801 gcaattagct gaagcaaaag aaaaaacgtg cagcacctgt gcagatgtgc aggttgccaa 439861 atcgactttg tcgcatcatt ttaaagtttt gagagaatca ggcatcgctc aagttcggat 439921 agaaggaaag cgccggtatt attcgcttcg cgctgaagac cttgaaaagg catttccggg 439981 actgcttgaa gccgtgctga atgtagacca ggaccgctgg tgaatcaatc ccctgtaacg 440041 gggatttttt tatgtccgta aaccgctttg aaaagccgct gcacaccctc ctgaatatct 440101 tcttccttca gccgtgcaaa gccgataatg agagcaggcc tgcccgtttg ccgcttgttt 440161 tccttcaagt taaatcggct cattccgaat atttcaagct gcagcccggc agcatgtgac 440221 aggatgtctt gttcggtgcg cctggtatca aattcggtaa caaaatgcag ccccgcattt 440281 gcccctttta cggtaacctc tccgctgaac tctgcttcta aagcggtgat caggcgttct 440341 ctcttttctt tataatgctg cttcattttt tttatatgct tctgatattc accagactcg 440401 ataaattcct gcagggtgag ctgtgtgagt gatgagcaag tctgcagatc atagccccgc 440461 tgtttgtatg ccctcaacag ctcaggcggc aacaccatat agctgatccg taagccgggg 440521 agaagggact ttgaaaaggt tcccatatag atgacatttt gaaaacggtc gaggctttgc 440581 agcgccggaa tactgtctac atcatatgtg aattcactat cataatcgtc ctcaatgata 440641 tatcggcgcg gctcctcggc tgcccagttc agcagctgaa ttcttctgga tacaggcata 440701 atcgttccgg acggaaactg atgcgacggg gtggtcacca gcacatctgg ctgctgtctg 440761 gtgatttcag caatcgacat gcctttttca tccagcatga tcgtctttac ttgttttccg 440821 gcattcttca aaagctgata catgcgcctg tagccaggct cctccatcgc atacacggct 440881 tccttgggta aaagctcagt caacagctgc atgagcacct gtgtgcctgc ccctatgatc 440941 atttgttccg gcctgcattt tacacccctc gtcagggaaa tgagcctcgt aatggccgct 441001 ctcacttcat atatcccttg cggatgtgac atatcgccga gcgtgcggta tgagcgggag 441061 gccgcttttt gctcgcagcg gaaccagctt ttgatcggaa aatggtctgt atcggaactc 441121 atgtgtgaaa acgatatcca atcgctctgg tcgatgtgaa tctcttttag gtcatccggc 441181 agtgcaaatg gagggtgctc ctcggcggaa aacatgtcta gttcctccac gaagaaaccc 441241 tttcgttcaa tggcgtacaa atacccctca gccagcagct gctgataggc tgaattcact 441301 gaatttacgc tgaccttgag attttcagcc agctcccgct tggagggaac cttcgagtgc 441361 ggcagcagat tgcggctgag gatttctttt ttcagctttt gataaatttg ctgatagata 441421 taatcggctt gttctgaacg atcgagtgta atcgtgatat ccattttgta gtttctcctt 441481 ctgataccat caaaaagtta taattggtac ttttcatcat accaaagaga agtcagaatg 441541 ataagaaaat accgacaggg ggatattcac atgagtcaaa caacagcaag catcacaact 441601 gcacaatggc agcaaaaacg ggatcaattt gtgtcaaaag gtgtgagcaa cggcaaccgc 441661 agtctggcgg tcaaaggaga aggggccgag ctgtacgatc tggatggccg gagatttatt 441721 gattttgcag gcgccatcgg cacgttaaat gtcggacact cgcatccgaa ggtggttgag 441781 gctgtgaagc ggcaggcgga ggagctgatt catcctggtt ttaatgtcat gatgtacccg 441841 acttatatcg aattagcaga aaaactgtgc ggcatcgcgc cgggcagcca tgagaaaaaa 441901 gcgatttttc ttaactcagg ggcagaagcg gtcgaaaacg ctgtgaaaat cgccagaaag 441961 tatacaaagc gccaaggcgt tgtctcgttt acacgcgggt ttcacgggcg cacgaatatg 442021 acgatgagca tgacaagcaa ggtaaaacct tataaattcg gtttcgggcc ttttgcgcca 442081 gaggtttatc aagcgccgtt cccttattat tatcagaagc cggccggcat gagtgatgaa 442141 agctatgacg atatggtcat tcaagcattc aatgatttct ttatcgcttc agtggcgcct 442201 gaaacggtgg cgtgtgtcgt gatggagcca gtgcagggag aaggcggatt tattattcct 442261 tcgaaacggt tcgtacagca cgtcgcttca ttctgcaaag aacacggcat tgtttttgtt 442321 gctgatgaaa tccaaaccgg ctttgccaga actggcactt atttcgcaat tgagcacttt 442381 gatgtagtgc ccgatctgat cacggtttct aaatcgcttg cggcaggcct gccattaagc 442441 ggtgtgatcg ggcgtgcgga aatgcttgat gcggcagcgc caggggagct gggcggcacg 442501 tatgccggca gcccgctcgg ctgcgcggcg gctttggcag tcttggatat tatcgaagaa 442561 gaaggactga atgagcgatc tgaagaaatt ggcaaaatca ttgaagacaa ggcgtatgag 442621 tggaaacaag aattcccgtt catcggtgac atccgcagac tcggggcgat ggccgcaatc 442681 gaaatcgtca aggatcctga cacgcgtgag cctgataaga caaaagcagc agcgatcgcg 442741 gcctatgcga atcaaaacgg attacttttg ctgacagcgg gaattaacgg taatatcatc 442801 cgctttttga caccgctcgt catctcagac agcctattaa atgaagggct cagcatcttg 442861 gaggcgggcc tgcgagctta atcattggaa agaaaatggc cgggtctgct atcattttaa 442921 gtaatcatga aaagaaagga atgttcaata tgccagatca attaacggtc tacaacccgg 442981 ctacgggcga ggagatcaaa acgattcctc agcaatcagc cacagaggta gaagaagcca 443041 ttgaacgttc acatcaagcg tttaaaacgt ggtctaaaac atcagcgaac gaaagaacgt 443101 ctcttttgaa aaaatggtat gagctgattg ttgaacataa agaagagctt gcagatttaa 443161 ttacaaagga aaacggaaaa ccataccagg aagcagtcgg cgaggtactt tacggcgcag 443221 gctatatcga atggttcgca gaggaagcga agcgtgtgta cggaagaacg gtcccggccc 443281 cgacaactgg taaacgaatt gttgtcacac gccagccggt cggccccgtt gctgctatca 443341 cgccctggaa tttcccgaat gcgatgatta cacgcaaagc ggcgcctgct cttgccgccg 443401 gctgtacatt tatcatcaag ccggcgccgg acacaccgct gtctgcttat gaactagcgc 443461 gcctcgcata tgaagcgggc attccgaagg atgttcttca ggttgtgatc ggcgatggag 443521 aagaaatcgg aaatgtgttc acaagcagtc cgaaaatccg caaaatcacg ttcacaggct 443581 caacacctgt agggaaaatc cttatgaaaa acagcgctga caccgtaaag cacgtctcaa 443641 tggagctcgg cggacacgcc ccgctgatcg tagatgaaga tgcggacatt gaccttgccg 443701 ttgaacaggc gatggcgtcc aaataccgaa acgccggcca aacctgcgta tgtgccaacc 443761 gcctgatcgt tcatgaatcc attaaagatg aatttgctgc gaaactgagc gagcaagtgt 443821 ctaagctgaa agtcggaaat ggacttgagg aaggcgtcaa tgtcggcccg attatcaaca 443881 aacgaggctt cgaaaaaatc gtcagccaaa tagatgatgc ggttgaaaaa ggcgcgaaag 443941 tgattgctgg gggcacatat gaccgaaacg atgacaaagg gtgctacttt gtgaatccga 444001 cagtgctcac cgatgtcgat acgtccatga acatcatgca tgaggaaaca ttcggcccgg 444061 tcgccccgat cgtcacgttt tctgatattg atgaagcgat tcagcttgcc aacgatacac 444121 cgtatggctt ggctgcttac ttcttcacag aaaactaccg ccgcggcatc tatatttccg 444181 agaatctaga gtatggcatt atcggctgga atgacggcgg accgtcagcg gttcaagcgc 444241 cattcggcgg aatgaaagaa agcggcatcg gccgtgaagg cggttcagaa ggtatcgagc 444301 cgtaccttga aacaaaatat ttgtccatcg gtttataaaa gaatgcacgc tcctgagagc 444361 tgccggattt tccggcagct ctttttgtgt tccggcgaat aatcacaaca attccagcca 444421 aaataacagc aaatacattt tgaaagaagg ttccccaaca atggatttat tattggctct 444481 tctcccggct ttgttttggg ggagcattgt tctcttcaat gtgaaattag gcggcgggcc 444541 gtacagccag acactgggaa cgacgatcgg ggcactcatt gtttctatcg ttatttactt 444601 ttttgttcag cccgttctgt cccttcgcat ttttattgtt ggaatcgtat ccggcttatt 444661 ttggtcactt ggacaggcca accagttgaa aagcattcaa ttgatgggcg tgtcgaaaac 444721 aatgccgatt tccacaggaa tgcagctcgt ttccacctcg ctgttcggtg tgatcgtgtt 444781 ccgcgaatgg tcaacaccga ttgcgattac gcttggcgtt ctcgctttga tctttatcat 444841 tgtgggaatc attctcacgt ccttggaaga taagaatgat aaaaaagagg gcgagccaag 444901 caatttgaaa aagggcattt tgattctcct tgtttcgact cttggttatt tggtttatgt 444961 agtcgtggct agattattca atgtgtccgg ctggtccgcg ctgctgccac aggcaattgg 445021 catggtggtc ggggggttag ttttaaccta tagacacaaa ccctttaaca agtatgcgat 445081 cagaaatatt ctcccagggt taatctgggc aggcggaaat atgtttttgt ttatttctca 445141 gccgcgagtc ggcgttgcaa cgagcttttc cctttcacaa atgggaattg tcatttctac 445201 gctcggcggt attttcatcc tgcgtgaaaa gaaaacgaaa cgccagctaa tagcaattgc 445261 gatcgggatt atcctgatta ttgccgccgc cgtattctta ggaatcgcca aaacaaattc 445321 ataacaaatg gaggaggatg tatatgtatc cggatttaaa aggaaaagtc gtcgctatta 445381 caggagctgc ttcagggctc ggaaaggcga tggccattcg cttcggcaag gagcaggcaa 445441 aagtggttat caactattat agtaataaac aagatccgaa cgaggtaaaa gaagaggtca 445501 tcaaggcggg cggtgaagct gttgtcgtcc aaggagatgt cacgaaagag gaagatgtaa 445561 aaaatatcgt gcaaacggca attaaggagt tcggcacact cgatattatg attaataatg 445621 ccggtcttga aaatcctgtg ccatctcacg aaatgccgct caaggattgg gataaagtca 445681 tcggcacgaa cttaacgggt gcctttttag gaagccgtga agcgattaaa tatttcgtag 445741 aaaacgatat caagggaaat gtcattaaca tgtccagtgt gcacgaagtg attccttggc 445801 cgttatttgt ccactatgcg gcaagtaaag gcgggataaa gctgatgaca gaaacattag 445861 cgttggaata cgcgccgaag ggcattcgcg tcaataatat tgggccaggt gcgatcaaca 445921 cgccaatcaa tgctgaaaaa ttcgctgacc ctaaacagaa agctgatgta gaaagcatga 445981 ttccaatggg atatatcggc gaaccggagg agatcgccgc agtagcagcc tggcttgctt 446041 cgaaggaagc cagctacgtc acaggcatca cgttattcgc ggacggcggt atgacacaat 446101 atccttcatt ccaggcaggc cgcggttaaa cataaaaagc gacccagaca tgacatctgg 446161 atcgctttct ttattaggca cgctttttct ttacaagtgc tgctacagat aaaataatgg 446221 cagccgcaga cagcaccatc gctgtaatgt ctagagctga agaacctgag ttttcggaat 446281 cgtcttctgt tttcgtggcg ccgtgctcat ctgtcacttg ctttgcagac gtgatgtttg 446341 taatggaatg aggtgtatcg gcatcctcgt cacctgtcca ctcaacaatg ctgccgtctt 446401 tgtaatattg gtatgcgtcc caagcagctt cctccgcttt gtcagggttt ttggcaacaa 446461 aggtaaactg ctggaactgg ccttcctgaa tgcctccgtc agtcgcctcc catgtcacgg 446521 atactgattt gtcatcatgt ttttgagtgg aaaccttcca gcccggaatt ggctcatatt 446581 gctggaattc aacatccttc ggcattttga ggacaacctt cgttgtcggc agatttttct 446641 cagaaggaac cttcattgta tacgtttccc aagagcctgc agcagactca gccggtttta 446701 cagaaacatg cgcgctggca ggggccgtaa agaataagag ggagccgaca atagccggac 446761 atagtgtcaa tgcgattttt ttcaacaacg taaacactcc ttaattggtc tttgtaaaca 446821 tgatattgat ttcgttaaag tcgccggtca ggccgtggac tttgatcttc cagtttcctt 446881 tttcattaat cgacaggttt tgatcttgga agacgccttt tgttttttct tttaatgtaa 446941 aggtgctttt gttttcgctg cctgacaggc ctgttttata aacggttaac gtgatttgct 447001 ggatgttttt cacgggatca ccgttatggt cggtgacccg cagctcaaaa acattttttc 447061 caggctggtt tgggctgatg ctgagagaaa cgctttgtcc gttctctatc gctttggttt 447121 ggtagaacgg ttccggcgct ggctcaggcg ggcttggcag gcttgtaaac acggccgctg 447181 tgatcaatac agcgatgccg attgcccact ccgctttcaa cgttcggctg attcctgtgc 447241 ggcgctgctt tctggtaagc agaaaatgaa ttgcgcctaa gaccagcatg aaaacaaaca 447301 gcccgctttt cactaaaaga gcttgtccgt acgctgtatg gaacagtgaa tccattgaac 447361 gaatgatgaa aaatccattg agcaagcctg aaaacaaaat gacgccgact gcagtgagcg 447421 cccatgggga gaaccgtctg accgtctccc acgcgagcgt tttgtcaggc tgcctccatt 447481 cttttgagag cagcaaaacg agtgccgcta ttccgccgac ccagatggaa gcggaagtta 447541 aatgaaggaa atccatcaaa atgccgaccg ttttttcttc aacgacagca gcatgcccgg 447601 taaacgcctt ggcaagcagg agaccgaaaa agaaaatgag cggcgctgtc caatagccaa 447661 aggatgaaaa gcggtttttc cgtatcgcag ggatgacaga cagtgcgagc agcacgaaca 447721 gcgcagcctg tatgatccaa atggagccgc ctgctgtctc aaacagtgtt tctctgatgt 447781 agcccggctg gaatgcgctg ccccagccgc cgcctgcgtt cgcttttgtc tgaatcggaa 447841 gctgaagcaa aagcgccagc cccaatgctg cgatcgagcc ggtcaggata cgtctcgtcc 447901 gtttgacgag ctgttctgat ttccctttat accagaaaag atggaagaaa accgttccga 447961 taaacagaga taaggctgta tacagaatcg cgcgatctgc tgctgttccc ggattcagcg 448021 ctgaatcggc tgctttttgg ctgctgaatc cgccatccgc tttcccgata ctgaacggaa 448081 tgacgccgga aacaggatgt ccatccgcgg atacggcatt ccattccgct ctgtacacat 448141 ctttaggcag attcttcttc agcttcactg tcatgatgtg atgattatct tttttgattt 448201 cagtcttgtc cgtatccaca cggtcgccgt ttgaattata gactttaatg taatgaaacc 448261 cttcttcaac cggttcatta aattcgattt ccacctgcgc aggggcgctt tttaattcgc 448321 tgttttcccc aggtgaagat ttgacaatat aggcgtgagc aaagcttgtt ttcggcagga 448381 aaacaagaaa aagcagaagg atgatccacc atctgtttcg cttcatcact cagacaccac 448441 cttccgctgt atgtgttgtg ttatttcttg gtgcaggtgc agcgtttctt tcggtcttga 448501 agcatgtctt ccagcgcttg gtcgaaagtg cagacggctc cgccgaatcc tttttgaaat 448561 cgttcggcat ggtcaagtgt cgcaaacgga atggcctgcg gctggcagca gtgcaggttt 448621 aattcagcat ttacgacgaa ataagccgaa ccggcactga cggttgtctg taacagaaaa 448681 tctctgcaaa tcaagtgtga aacctcttcc gttttatccg cgtaacgcaa aaacgcgcaa 448741 tgtgcgcagc atagctgttc aatgtcttgg tttaccgtaa tcagctgaac cgaatgagct 448801 tgattgacgg gcttcaagca atagctgcac atatgatctg tttgaggtgt tcggacgggg 448861 agcgtgatgc cgccggccgt tttaatgacc tgatttgact gaaccagctg attgacatct 448921 ctatataccg tcatttccga aacgccgaac cttgcgctga tgtcagaaat tctaagcgag 448981 ccttcttctt tcagccactt cagtatgtgt tgctgtctat taatcggaag cattcataca 449041 ccctcttcat taagatctat ttaagcgtag aggattttag agacggagac aagtaagtgg 449101 atgataaaaa atgtgaaaat gtgttgaaca gcaacaaaac gaaacagaag ggactctggt 449161 ataatagaca gatggaatag aaagtgagga ataccctatg aaagaaacac catgcccgaa 449221 ctgcggcaaa cctttgacag gcgatatggt cagatcatca aatgtgcctt gtcaatttcg 449281 ctgcggccac tgccgggaac ggctttatga atataaagtt tcagctccga ttatgctggt 449341 atcattagcg gccatcgtgc tgcttattta tcttttgatg ctcctccgca atgcggcagg 449401 ctcagtgctg ccagctgtac agcacgtgcc gatggctgta tttgcgcttg tgtgcgcgta 449461 tcccgttttt attgtgagtg agcggatgat tgcaaagtac gtgattcaaa atggcaacat 449521 catttataga ggaaagagaa aaggctcctg aaaccaggag cctttttatt tttaaaaaat 449581 tgtcacagtc atgtgccaaa gtcctcttta ctttcaattg tatagggact gtaagcgttt 449641 taacatagag tcaaagggaa gcatcattct ctgaacatat ttttgtatct tacagcgaca 449701 aacaaaacag ggagggttta tatatgcagc agcaagaaca gcagcaaggc ggcatgaaag 449761 tgaaagtgca acgctttggg agttatttga gcggaatgat catgccgaat atcggcgcgt 449821 ttatcgcgtg gggtatcatt accgcgctgt ttattccggc aggatggttt ccgaatgaac 449881 agctgaacac gctggtcagc ccgatgatta cgtatttatt gccgcttttg atagcgtata 449941 caggcggaaa aatgatctac gaccaccgcg gcggagttgt cggagcgaca gcggcaattg 450001 gggtgattgt aggatcggat attccaatgt ttttaggcgc aatgattatg ggtccgcttg 450061 gcggatacct cattaaacag actgataaat tattcaagga taaagtcaag caaggctttg 450121 aaatgctgat caacaacttt acggcaggga ttgtcggcgc ggctttaacg attctcgcgt 450181 tttacgccat cggcccggtt gtcttgacgc taaataaatt gctggcggct ggtgtggaag 450241 tcattgtaca cgctaattta ctgccggtag ccagtgtttt tgtagaaccg gcgaaagtgt 450301 tgttccttaa caacgccata aaccatggaa tcttaagccc gatcggaatc gagcaagcat 450361 ctcaaacagg aaaatcaatt ctgtttttag tagaagcaaa ccctggaccg gggctcggca 450421 ttttgctggc ctacatgttc tttggcaaag gatcttcaaa atcaacggct cccggtgcgg 450481 cgatcatcca tttcttcgga gggattcacg agatttactt cccgtacatt ctgatgaaac 450541 cggccctgat tctcgcagcc attgccggcg gagcaagcgg actcttaaca tttacgatct 450601 ttaatgccgg acttgtcgcg gcagcgtcac cgggaagcat tatcgcattg atggcaatga 450661 cgccaagagg aggctatttc ggcgtattgg cgggtgtatt ggtcgctgca gctgtatcgt 450721 tcatcgtttc agcagtgatc ctgaaatcct ctaaagctag tgaagaagac ctggctgccg 450781 caacagaaaa aatgcagtcc atgaagggga agaaaagcca agcagcagct gctttagagg 450841 cggaacaagc caaagcagaa gaagcgtctg agctgtctcc tgaaagcgtg aacaaaatta 450901 tctttgcgtg tgatgcggga atgggatcaa gtgccatggg ggcatccatc ttaagaaaca 450961 aagtgaaaaa agcggagctt gacatcagtg tgaccaacac ggccattaac aatctgccaa 451021 gcgatgcgga tattgtcatc acccacaaag atttaacaga ccgcgcgaaa gcaaagctgc 451081 cgaacgcgac gcacatatca gtggataact tcttaaacag cccgaaatac gacgagctga 451141 ttgaaaagct gaaaaagtaa tcttatagaa agagagtgat tgtcatgcaa gtactcgcaa 451201 aggaaaacat taaactcaat caaacggtat catcaaaaga agaggctatc aaattggcag 451261 gccagacgct gattgacaac ggctacgtga cagaggatta cattagcaaa atgtttgaac 451321 gtgaagaaac gtcttctacg tttatgggga atttcattgc cattccacac ggcacagaag 451381 aagcgaaaag cgaggtgctt cactcaggaa tttcaatcat acagattcca gagggcgttg 451441 agtacggaga aggcaacacg gcaaaagtgg tattcggcat tgcgggtaaa aataatgagc 451501 atttagacat tttgtctaac atcgccatta tctgttcaga agaagaaaac attgaacgcc 451561 tgatctccgc taaaagcgaa gaagatttga tcgccatttt caacgaggtg aactgacatg 451621 atcgccttac atttcggtgc gggaaatatc gggagaggat ttatcggcgc gctgcttcac 451681 cactccggct atgatgtggt gtttgcggat gtgaacgaaa cgatggtcag cctcctcaat 451741 gaaaaaaaag aatacacagt ggaactggcg gaagagggac gttcatcgga gatcattggc 451801 ccggtgagcg ctattaacag cggcagtcag accgaggagc tgtaccggct gatgaatgag 451861 gcggcgctca tcacaacagc tgtcggcccg aatgtgctga agctgattgc cccgtctatc 451921 gcagaaggtt taagacgaag aaatactgca aacacactga atatcattgc ctgcgaaaat 451981 atgattggcg gaagcagctt cttaaagaaa gaaatataca gccatttaac ggaagcagag 452041 cagaaatccg tcagtgaaac ggtaggtttt ccgaattctg ccgttgaccg gatcgtcccg 452101 attcagcatc atgaagaccc gctgaaagta tcggttgaac catttttcga atgggtcatt 452161 gatgaatcag gctttaaagg gaaaacacca gtcataaacg gcgcactgtt tgttgatgat 452221 ttaacgccgt acatcgaacg gaagctgttt acggtcaata ccggacacgc ggtcacagcg 452281 tatgtcggct atcagcgcgg actcaaaacg gtcaaagaag caattgatca tccggaaatc 452341 cgccgtgttg ttcattcggc gctgcttgaa actggtgact atctcgtcaa atcgtatggc 452401 tttaagcaaa ctgaacacga acaatatatc aaaaaaatca tcggtcgctt tgaaaatcct 452461 ttcatttcgg acgatgtgac ccgcgtagcg aggtcacctc tcagaaaact gggagaaaat 452521 gatagacttg taggcccggc aaagaaaata aaagaaccga atgcactggc tgaaggaatt 452581 gccgcagcac tgcgcttcga tttcaccggt gaccctgaag cggttgaact gcaagcgctg 452641 atcgaagaaa aaggatacag cggcgtactt caagaggtgt gcggcattca gtcccatgaa 452701 ccgttgcacg ccatcatttt aaagaaactt aatcaataac cgaccacccg tgacacaatg 452761 tcacgggctt tttttactat ctcgcaatct agtataatag aaagcgctta cgataacagg 452821 ggaaggagaa tgacgatgaa acaatttgag attgcggcaa taccgggaga cggagtagga 452881 aaagaggttg tagcggctgc tgagaaagtg cttcatacag cggctgaggt acacggaggt 452941 ttgtcattct cattcacagc ttttccatgg agctgtgatt attacttgga gcacggcaaa 453001 atgatgcccg aagatggaat acatacgctt actcaatttg aagcagtttt tttgggagct 453061 gtcggaaatc cgaagctggt tcccgatcat atatcgttat gggggctgct gctgaaaatc 453121 cggagggagc ttgagctttc cattaatatg agacccgcca aacaaatggc aggcattacg 453181 tcgccgcttc tgcatccaaa tgattttgac ttcgtggtga ttcgcgagaa cagtgaaggt 453241 gaatacagtg aagttggcgg gcgcattcac agaggcgatg atgaaatcgc catccagaat 453301 gccgtgttta cgagaaaagc gacagaacgt gtcatgcgct ttgccttcga attggcgaaa 453361 aaacggcgca gccatgtgac aagcgccaca aagtctaacg gcatttatca cgcgatgccg 453421 ttttgggatg aagtctttca gcagacagcc gctgattata gcggaatcga aacatcatct 453481 cagcatattg atgcgctggc cgcttttttt gtgacgcgtc cggaaacgtt tgatgtcatt 453541 gtggcgagca acttgttcgg tgatatttta accgacatca gctcaagcct gatgggaagc 453601 atcggcattg cgccttctgc gaacatcaat ccatccggca aatatccgtc catgtttgaa 453661 ccggttcacg gctcagctcc tgacattgcc ggacagggcc ttgccaatcc gatcggccag 453721 atttggacag cgaagctgat gctcgaccac ttcggagagg aagaattggg ggcgaaaatt 453781 ctggatgtaa tggagcaagt gactgccgac ggcatcaaaa cacgcgacat tgggggacaa 453841 agcacaacgg ctgaggtcac tgatgaaatc tgttcgcgct taagaaagct ctgatgaatc 453901 aggccggtgg cagatggctg ccccggcctg tccatttcct tacgaaaatt tccacgaaag 453961 tctaaccaag cagatccaaa tgctgtataa taatttggaa ttcttaggaa agcatcgggt 454021 gaaggaagtt gaatgcaaaa acaatcacgt taaagaaaaa aagaaaaatc aaaacgatcg 454081 ttgtactcag tatcattatg atcgcagctc tcatttttac gatcagattg gtgttttaca 454141 agccttttct tattgaagga tcatcaatgg ccccaacgct taaagactca gaaagaattc 454201 tggttgataa agcagtcaaa tggactggcg ggtttcacag aggagacatc atagtcattc 454261 atgacaaaaa gagcggccgc tcatttgtca aacgtttaat cggtttgcct ggtgacagca 454321 ttaaaatgaa aaatgatcag ctatacataa atgataaaaa ggtggaagaa ccatacttaa 454381 aggaatataa acaggaggtc aaagagtcgg gtgtaacctt aacaggtgac ttcgaagttg 454441 aggttccttc cggtaaatat tttgtgatgg gagataaccg tctcaattca ctggatagca 454501 gaaacggaat gggcatgcct tctgaggacg atatcatcgg tactgaatct ctcgtctttt 454561 atccattcgg tgagatgaga caggcaaaat aaaatgcaat gcaaaaagaa catggaacat 454621 gacggcaccg ataataaagc gccgtgcacg tttaaaaaaa tgatgatgaa acggtgcgga 454681 gccggctttc cgccccgttt tttatgatag aaagcgtttt gaagaaaagg gccctgttga 454741 aataaacaga atcaggattg gcgaagccgt gaagcgcatc gaattggtaa atctcaagat 454801 gggtatgctg tttttcccgc agttttttga taagaagcgc tacgtcaaac gacggctcat 454861 aattagggaa aaacaatagg accgggcagg ctggcatgtg atgaagagag tcgcgtatcc 454921 gggaaccgta ataacaaacc gatccgctca cctcaggcat actgctgcat ttccatgcga 454981 tagtagcccc cacgctgaat ccaatcacaa agatgtgccg tccggcgttt tgcctgatca 455041 cattctggat gatggtttct cccgttttca gcctttcgtg ttttgtaaat tgttcgtatg 455101 ccgttttttc ttctttcagt gtgtagactt catcctcgcc gagcaggttg ggcgtcaaca 455161 catcatatcc agccattttg atcagccggc ccatcttttt catatggctg tttacaccat 455221 atatttcgtg tgcgagaatg acaagcggtt ttgggaacat aacggcctcc ttttgtgttt 455281 tttccattat atcctatcgt ttcactttag gctgagatat aatggtcaaa aaaaggagat 455341 ataaaatgaa ctcattatct ttgcctcacc gctatccatt tttgtttatt gatggcgtga 455401 cggatagcga gcccggcaaa catgcggcag cttataagct gattagtgag aacgactggt 455461 ttatcactga tacgcaaaca gaaatgccgt tttcacttgt gattgaagcg cttgcgcaaa 455521 ccgcggcttt tacaggaatt acagatgaga acagcttggg attattgtct tcggtgaaga 455581 aagcggaaaa gctgggagaa gctgtgcctg gtgaccggct tgatcttacg tttgaagtca 455641 cgcgcaatcg gcgcgggttt gtgttcggac atgccaaggc atcagttgga gagcagcctg 455701 ttgctgaagc tgaaatcggc atctatattg aaaaatgaaa aaaacccttc acaacatttt 455761 gtgaggggtt ctattttgtg tcgtaatccc gttcgctttg agagttatct ctttgctggc 455821 gtttgtgttt ttcatcattc atattttcct tcagctcttc attaggaatc ggatcggtta 455881 agtcgttgtg ctcggggttt tcatttggtt tgttttgctg ttttttttct gtcatgtttg 455941 atcacctcac cgtttgtttt cctcttattc attctcctca aacataggaa atcgcttttt 456001 tgtcccgctg ggtataatgt attagaatag agagaagcac aacaaaaaga taaagagagg 456061 tacatatatg tctgttcaaa gagaagatgt agatatcaag ctgatcgcaa ttgatatgga 456121 tggtacactg ctgaacgacg agcagctgat ctcggatgaa aaccgcaaag ccattcgtga 456181 agcggaggat aaaggtgtgt atgtggtgat cagcacgggc cggacgctga tgacgtgcag 456241 ggagctggcg gaatcgctaa agctgtcatc ctttctaatc acggcaaacg gcagtgaaat 456301 ttgggattcg aattttaatt tggtggaacg gaagctgctt catacggacc atattcaaat 456361 gatgtgggat ttgcggaata agcacaacac taatttctgg gcttctacgg tgaataaagt 456421 atggagaggc gagtttccgg aaaacattac ggatcatgaa tggctcaaat tcggctttga 456481 catcgaggat gacgatatcc gaaacgaagt gcttgaggag ctgagaaaaa acaaagagct 456541 cgaaatcaca aattcaagtc cgacaaacat tgaagtcaac gcgcttggca tcaacaaagc 456601 tgcagccctt gccaaggtta cggaaaaact cggctttaca atggagaatg tgatggcgat 456661 gggcgacagc cttaatgaca ttgcgatgat caaagaagcg ggtcttggcg tcgcaatggg 456721 caatgcgcaa gacatcgtaa aagaaacggc tgattatatc acggatacaa atattgagga 456781 tggtgtcgct aaagcgattc gccattgggt actataaaaa aagagagtcc taagatggac 456841 tctctttttt agtttggcag gttttattct gggaccatgg taggttttct gacaaaagta 456901 tttcacaaac tgatatgatt cacttataat gaaataaagt tcaaaaattc ggaatagtcg 456961 ttccgaattt cgggacaata aatgacataa agcatatcgt ttgctttggc aggagggatt 457021 ctgtgtttca gattgattta aactgtgatt taggagaaag cttcggagcc tacaagatag 457081 gccttgacca agatatttta gagtatgtga catcagcgaa tatcgcatgc ggatttcatg 457141 caggagatcc tagtgttatg cgaaaaaccg tcgcgcttgc agcagaaaga ggcgtgaaaa 457201 tgggtgcgca tccgggcttg ccggatttac tcggttttgg gcgccgcaat atggcgattt 457261 ctcctgagga agcgtatgat cttgtcgttt atcaaattgg cgcgctctct ggctttctaa 457321 aagcagaggg acttcacatg cagcacgtca agccgcatgg cgctttatac aatatggcgg 457381 cagtcgatca aaaactgtcg gatgctatcg cgaaagctgt ctataaggtt gatcccggcc 457441 tgattctttt cggtcttgct gagagcgagc ttgtaaaagc gggagaacgg atcggacttc 457501 agaccgcaaa tgaagtgttc gccgacagaa cataccaatc ggacggcacg ctgacaccgc 457561 gctcccagcc ggacgcactc attgaaagtg atgatgccgc cgtcacccag gtcatcaaaa 457621 tggtgaaaga aggggcggtc aaatctcagc aaggacatga tgtgtcatta aaagcagata 457681 cagtctgcat tcatggagat ggagcccatg cgctgacatt tgcgcaaaaa atcagaaaac 457741 agctcaaagc ggctggaatt gaagtgacag ctatttcaga acagaggtca acataaagga 457801 ggaacaatag atggagcagc agaaaaagac agcaggaaaa aaagcgggca gctggtcatt 457861 gctgatgggc gccgcctttt taatggcgac atcagcaatc ggaccgggtt tcctcaccca 457921 aaccgcaaca ttcacaaaca cactcgcagc aagcttcggt tttgtcatct taatctctat 457981 tattttagat attttcgccc aaaccaatgt gtggcgcatc atcgcagttt ctggaaaacg 458041 aggtcaggaa attgcgaata tggtgcttcc cggactgggg tatttcatcg ccattctcgt 458101 cgtgcttggc ggactagctt ttaatattgg gaatatcgga ggggccgggc tgggacttca 458161 ggtgctgttc ggcattacac ctgaaacagg cgctttaatc agtgccgtta tcgccatttt 458221 gatttttgtc atcaaggaag caggaaaagc gatggaccgt tttacgcaaa tcgcggggtt 458281 cgtgatgatt attttaacgg tctacgttgc ggcgacgaca gctcctccgg tcggacaggc 458341 agtcgcaaat acattcgtcc cggaacacat cagcatattt gccattgtca ccctagtggg 458401 cggaaccgtc ggcggttata tcacatttgc cggaggacac cgtttgcttg atgccggaat 458461 taaaggaaag gaatccattc cgcaggtgac aaagagctcg gttgtcggca ttttaattac 458521 atctgtcatg cgtatcgctc tttttcttgc ggttctaggc gttgtatcga aaggcctgca 458581 catcgatgaa agcaacccgg cggcttctgt cttcaagctg gctgctggaa atgtcggtta 458641 taaaattttc ggattgatca tgtggtctgc ggcgattacg tctgttattg gagcagccta 458701 tacatctgtt tcatttttta aaaccttttc tccaaaaatt gaaaagaatt cacgcggtat 458761 tattatcgga tttattgtgg tttctacgtt agcttttgtc acaatcggcc agcctgcgaa 458821 gatcctcgtc cttgtcggtt cactgaacgg cttaattctg ccgattgcgc tcggaacgct 458881 gcttgttgcc gcctacaaga aaaacattgt cggtgattat aagcatccgc tttggctgac 458941 aagcacaggc gcgcttgtag tgattgtaat ggcagttatg ggaatctaca cgttatgtac 459001 acaacttcct caattgtgga gctgatataa gtggagcaat taaacaaaat ggcgccaaag 459061 gatgtacgcg ccctgatacg agaggggaaa ataaacgggc cgaccgcagg catgtccggc 459121 ggctacgccc aagcgaatct tgtggttttg aaaaaggacc ttgcgtttga ttttctgctg 459181 ttttgccagc gaaatcaaaa gccctgcccc gtgctggatg tgactgaagc aggttcgcct 459241 gtgccgtctc tggctgcgcc ggatgctgat atcagaacgg actttccgaa ataccgtatt 459301 tacaggcacg gtatcctaac ggaagaagta tctgatatta cgccatactg ggaggacgat 459361 tttgtcggct ttctgatcgg atgcagtttc tcctttgaac aggcactgat caataatggg 459421 atagctgtcc ggcatattga tgaggggaca aacgtctcaa tgtataaaac gaatatcgat 459481 tgtgttccgg cgggggcgtt tcacggacag atggttgtca gcatgaggcc ggttcctgaa 459541 cggctggctg tacgtgctgc acaagtgacc tcgcgttttc cggctgtgca cggagggccg 459601 atccatattg gcaatccggg agcaatcggg attcgcgatc tcgggaaacc ggatttcgga 459661 gatgccgttt ccattcgtga cggcgaggtt cctgtttttt gggcatgcgg agtgaccccg 459721 caagccgtgg ctatgaatgt aaagcctgaa atggtcatca cacatgcgcc ggggcatatg 459781 ctcatcacag atattcgaga cgagtcgctt gcggtgctgt agcctctcgt catcctgatg 459841 aacgagaatt aaaagaggtg agaaagatga ctgtacgata tcaaatcgaa cagctcggtg 459901 attctgcaat gatgatccga ttcggagaag aaatcaatga acaggtcaac ggcattgtcc 459961 atgcagcggc cgcttatata gaagaacagc catttccggg attcattgaa tgtatcccgg 460021 cttttacaag tctaaccgta ttttatgata tgtatgaagt gtacaagcat ttgcctcaag 460081 gcataagctc accttttgag agtgtcaagc gcgatgtcga agagcggctg gcagaaatag 460141 ccgaagacta tgaggtcaac cgccgtattg tagaaattcc cgtttgctat ggcggtgaat 460201 tcggtccgga tttagaagag gtggcgaaga tcaatcaact gtcaccggag gaagtaatcg 460261 acattcatac aaacggtgaa tatgtggtgt atatgcttgg cttcgcgccc ggttttcctt 460321 ttctaggcgg gatgtcaaaa cgcattgcag ctccgagaaa atcatcgcca agaccgtcga 460381 ttcccgcagg ttcggtcggt attgcgggat tgcagacagg cgtttatccg atttcaacgc 460441 cgggcggctg gcagctgatc ggcaaaacgc cgctggctct tttccggccg caggaaaacc 460501 cgccgacatt gctgcgggcg ggagatattg tgaaattcgt tcgcatctca gaaaaagact 460561 atcacgccta taaggaggag tccaattgag catgaaagta ttaaagcccg gactgctcac 460621 aacggttcag gatataggca gaacgggtta ccaaaaatac ggcgttctgg ccagcggcgc 460681 tatggacacg gtttcactgc gcattgccaa tctgttgata ggaaacggcg aaaatgaagc 460741 aggtctcgaa ataacgatga tggggcccgg tccgtcgttt catttttcaa aacagacact 460801 gattgctgtg acaggggcgg acttcacgct gcgtattaat gacgaggaag cgcctttatg 460861 gaagcctgtg ctcatcaagg aaaacagcac ggtcagcttt ggcccctgca aactcggcag 460921 ccgtgcttat ttggcggcag ctggcggcat tgaggtgcct gccgtcatgg aaagtaaaag 460981 cacatacgtc agaggaagca ttggcggact tcatggcaga gcgcttcaaa aagaagatga 461041 actgaacatt ggagagatgt cagctctttc gcaaaccatc ctttctcgct taagttcgca 461101 gcttggaaaa cagggatttg cagcaccgaa gtggtcagtc agccgcggca gatttctgcc 461161 attgaagaag aatcccgtca ttcgggtgct ggaaggaaag caatttgcct ttttcacaga 461221 agaatcaaaa acgcgttttt atgaagaagc atttcgtgtc acgccgcagt ccgaccgtat 461281 gggctacagg ctcaaaggag aaccgctcga actgaaggcc ccgcttgaga tggtgtcgga 461341 agcggtttca ttcggaacag ttcaggtgcc gcctgacggc aacccgatta tcctgcttgc 461401 agaccggcag acgactggcg gctatccgag gatcgcgcac atcatatccg ctgatcttcc 461461 gattgtttcc caaatcatgc cgggcgagca cgttcagttt gagcctgtgt ccctccagga 461521 ggcagaagcg cttgcggtag aacgggaaca gcatataaaa gaactgaaaa cgagaatgaa 461581 gatggaatgg ctgacatagc aaaggggatg aatgatgcag aataaaaata aaaccgtagt 461641 caaatctatg gcgctgctta atttgttttt gcataaacca agcctaacct taagtgaact 461701 ggtgtcgctg acgggaatgc cgaagacctc tgttcaccgg atggtcagct ccttggagga 461761 aatggggttc ctcagtcggg atgcgtccgg cgcttattcg ctgggattgg tgtttttgga 461821 attcggacag cttgtcgctg acaggctgga tatcagaaaa atagcgaaac cggtgatgga 461881 agagctgtgc cgggaagtgg atgaggccgt gcagttgatc atgagggacg gcaatgaagc 461941 gatatacgtt gagaaaatag aagggacaca gactgtgcgg ctgtatacgg cgatcggcag 462001 gcgttccccc ctatacgcgg gagcgtgcgc cagaagcatt ctgtcctttc ttccccgtga 462061 agaaatcgaa gcatacatca aacaaaccga gctcatttcg attggctccg gaacgattac 462121 cgatcccgaa aaactgcttc aggagattga tgcctctgtg caaaatggct atactgtcag 462181 ctattcagag ctcgaaaact atacggcggc gatcggcgcc ccgatcttta accatgagcg 462241 ccaggtggca gccggcatta gcattgcagg ctttgaagcg agatttacag aagacaggct 462301 gccctattta acagaaaagg tgaaggacgc cgctttacag atttcaagaa aaataggata 462361 tacataagta gccaatcttt tctctgctgc gtacattaac gtatcgacgt tcaagagtgg 462421 aggaaagaac atggtgcttc gatatacagc tctgggcgat tccttgacga cagggagagg 462481 ctccgggctg ttttcacccg gcttcgtcca gcgttttggg gacatgatgg aagctgactt 462541 gaaaacaaga acggcaataa acatatttgc cagatcaggt ctgaatacag aagagatttt 462601 gggactcctg tcatatccct atgtgcaaaa atgtattcga gatgctgata tgataacgat 462661 cacagggtgc ggaaacgatc tcatcgattc ggtcttagcc taccaaacct ctaaggatga 462721 aacgattttc agccgtgtat ccgcccattg ccatgagaat tttgaaaaga tgattgccaa 462781 agtcgccgag attaaaggag aaaatccttc cccgtacgcc attcgtgtgt tcaacttata 462841 caatccgttt cccgaaattg atatcgccgg caaatggatc acttcgttta attcacattt 462901 agaaacactt gcatcagcac cccatgtcaa aatcgcggat gcctatagca tcttcaaagg 462961 caaagaacag gaatatctgt cctttgacgg tgtccatccg aacagcaaag gctatcaagc 463021 gatggctgaa gccgttcaca agctaggcta taaagaatta tcagtttcat agaaaacgcg 463081 cctcatgaca ggcgcgtttt ttatgtgtga tcgaaatatt aaaagaaact taaaattctc 463141 tgtcttctgt tctacagaca aacaaagtgc gctagaataa tggagggcgt aggcaaatat 463201 agccataacg ttcaatattt cgtatataag gaaggatggt ccttttgttt cggattttta 463261 aaatgtcttt tgcggttatc attattatac tggcgcttat tgcttttaac tatacggaac 463321 acacctctgt aatccaatcg gtcatgctcg tctttcttgg tgcggtcatg tttatgcagg 463381 ggcttgaaga gcgcaaaaaa gaaaatgacg gctcaggcgc ttttaatatt tataccgccg 463441 tttttgtatg gtctgtctcc cttatcggtt ttacacttca tattatataa atctattaca 463501 catcctgaaa atgctcgacc gtcgggaacg gggtatagaa ccgatgaagc aaggctttcc 463561 actcttgata ctctgaagaa ccgcgaaagc cttccgtatg gtcctcaagt gtttcccact 463621 ccacaagaag cagatattta tgcgtttcct ccatgcattt tgataacgag tgagtgatat 463681 agcccttcat gccggaaata atcggcgcag cttgccggaa tgcatcctca aactcttgtt 463741 caaggccttc tttaatgtga agcattgctg cctctctgac catgctatcc cttctttctg 463801 tcttttcaaa tagtctacag caaacgatag gagatttctg caaaatcggt gaacttttcc 463861 ttcattttca aaaaaatctt gcacgcacca attcaattaa gagaaaataa caagtggaag 463921 gcaggggaaa gtcatgttaa aaaagtgtat tctactagta tttctatgcg tcggattgat 463981 tgggttaatc ggatgctcca aaacagattc accagaggat cgcatggaag cattcgtgaa 464041 acagtggaac gatcagcaat tcgatgacat gtatcaaagc ctgactaaag atgtcaaaaa 464101 agaaatctcc aaaaaagatt tcgtcaacag gtataaagcc atctatgagc aggccggcgt 464161 aaaaaatttg aaagtcactg cgggagaagt agataaggac gatcaagaca acaagacgat 464221 gaaacatatc ccgtataaag tcagcatgaa cacaaatgcc ggcaaagtca gcttcaagaa 464281 tactgctgtg ctgaaattag aaaaaacaga tgacgaggag tcatggaata tagattggga 464341 cccatcgttt attttcaagc agctggctga cgacaaaacc gtgcaaatta tgagcattga 464401 accgaaacga ggccaaattt acgataaaaa tggaaaaggc ttagccgtca atacagatgt 464461 tccggaaatt ggaattgttc ccggagagct tggcgataaa aaagagaaag tcataaaaga 464521 actcgccaaa aaacttgatt tgactgaaga cgacatcaag aaaaagctgg atcaaggctg 464581 ggtaaaagac gattcgtttg tgccgctcaa aaaggtcaag cctgaccagg agaaattagt 464641 ttctgaagcg acgtcattac aaggcgtaac aagaacgaat gtcagctccc gctactatcc 464701 gtatggcgaa aagacagccc atttgacagg ctatgtccgc gccattacag cggaagaact 464761 gaagaaaaag aaagaaggaa cgtacagcga tacgtctaac atcggtatcg ccggacttga 464821 aaatgtgtat gaagacaagc taagaggcac aactggctgg aaaatctacg tgccgcaaac 464881 cggggaagtc atcgctgaaa agaaagcaaa ggacggcgag gatcttcacc tcacaattga 464941 tatcaaaacg caaatgaagc tgtatgatga actgaaggat gacagcgggg cggcagtcgc 465001 gctgcagccg aagacaggcg aaacactcgc ccttgtcagc gcgccttcct acgatccaaa 465061 cggatttatt ttcggctgga gcgataagga atggaaaaag ctaaacaaag ataaaaacaa 465121 tccgttttca gcgaaattca ataagacata cgcgccaggt tctaccatta aaccgattgc 465181 ggctgctatt ggaatcaaaa acggcaccct taaagccgat gagaagaaaa caatcaaagg 465241 caaggagtgg caaaaagatt caagctgggg cggctattca gtgacacgtg tgtctgagag 465301 acttcaacaa gtcgatttgg aaaacgccct tattacgtca gacaatattt attttgccca 465361 gaatgcgctt gatatgggag cggacacctt tacaaaaggc ttgaagacat tcggtttttc 465421 agaggacgtt ccgtacgaat tcccgatcca gaaatcgtct attgcaaatg acaagcttga 465481 ttcagacatt ttgcttgcgg atacaggcta cggacaaggg caaatgcaaa tgtctccgct 465541 tcacttggca actgcttaca cgccatttgt tgacaatgga gaccttgtca aaccgacgct 465601 gatcaaaaaa gattcacaaa cagctgatgt ttggcacaag caagtggtca cgaaggaagg 465661 agcggcagac attacaaaag gtctgaaagg cgttgtggaa gatgagcgcg gatcagcgta 465721 tcagcctgtc gtgaaaggaa tcacagtggc tggaaaaaca ggaacagccg agctgaaaac 465781 atcaaaagat gataaagacg gcacggaaaa tggctggttt gtcggctacg attacgaaaa 465841 caaagacctg cttgtcgcca tgatgatcca aaatgtgcag gaccgcggcg gcagccacta 465901 tgtcgttgag aaagcgaaaa agcaatttca atcgaattaa aatgtctttt taaaaggagc 465961 gaaaggaaaa aggggatctg aggccgaatg aactagtaag ggggcaaaac ccggtttata 466021 caaagaaaag agggattttg catgcagcgt attcaattgg cggaggatct tcaattttca 466081 agagtcatac acgggctttg gcggctgaat gaatggaact attcagatgc tgaacttcta 466141 agcctcattg aatggtgtat cgatcacggc atcacgacct ttgatcatgc ggatatttat 466201 ggaggctata cgtgcgaaaa gctgtttgga aacgcccttg ccctttcgcc tggattaaga 466261 gaaaacatag agttggtcac aaaatgcggt atcgttcttg aatcgcctga acggcccgct 466321 cacagatcgc atcattataa cacaagcaaa tcgcatattt tggcatccgt tgagcaatcg 466381 cttatgaacc ttaggacgga ttatatcgat atgcttttga ttcacagacc ggacccgctc 466441 atggatccgg agggggtagc agaggcgttt caggccttga aatgctctgg caaggtcagg 466501 tactttggcg tttcaaattt taaagatcac cagtatcgga tgctggaatc atatttgcct 466561 gagaagctcg taaccaacca gattgagctt tccgcatacg aattagaaaa tatgctcgac 466621 ggcactttga acctgtgcca ggaaaaacgg attccgccga tggcttggtc gcctctggca 466681 ggcggcaaag tattcactga aaacacggat aaagaccgac gtgtccgtac ggcgcttgaa 466741 tccgtccaag gggaaatcgg cgccgcttca ttggacgagg tgatgtacgc atggctgtat 466801 acgcatccgg ccggcatcat gccgattgtc ggaagcggaa agcgcgagcg gatttccgcc 466861 gcgataaatg cgttgtcata caagcttgac caggatcaat ggttccgcat ttttacagcc 466921 gtacagggtt acgatattcc ataaaaagca tcagtttacc agctgatgct ttttcaatat 466981 tgtcacaccg cttagtgcca aattaccatt tataagtgat tgattctttc ttgaaagcgt 467041 tttatattaa aaggaaacct ctctatatcc tctactgcat ctccttgcga cttcatccgc 467101 acatcaagat tggctaggag gtctttttta tgtatatgac tgccagagaa caaaagctgt 467161 taaagcactt attattacaa aacagatata taaccgtaac tgagcttgct gagctgatgc 467221 aagtcagcac gagaaccatt cacagggaac tcaaatcaat taaaccgctg atggaaaccg 467281 tggggcttac gttagataaa cagcccggta aagggttgaa agcagtggga agtcccgagg 467341 gtaaacaaaa gctgcttact gatttatcat atgaacagca tgaatacagc gccgacgaac 467401 ggaaactgct cattctttgt tcgttattag agtctcagga gcccgtcaaa ctgtacacgc 467461 ttgctcatga tctccaggtg acgaatgcca cggtcagcta tgacttagat gagctcgaga 467521 agtggatttc tccctttgga ctgacactga tccgcaaaag aggttttggc atccagctca 467581 tagggccgga gaatgcgaaa cggaaaattg tcggcaactt gattgtgaac cgtctcgaca 467641 tccaaatgtt tttggaagcg gttgaattaa acatcaaagg aaaaaccgat tcttcagaga 467701 aaatgttcgg ggttgtcagc aaaggtgagc tgttaaaaat ggagcgcatc ttatttcagc 467761 tcaaagaaaa aatcgctttt tcattgtccg acagctccta tatagcgctc gtcgtccatc 467821 tgacgtatgc gatcgaacga attaagcttg gggaaactat caccatggag caaaatgagc 467881 ttgaggaact gatgaatgcg aaggaataca gctccgctct tgaaatcgcg ggcgagcttg 467941 aacgtgcctt cggcgtgacg attccagagg cggaggtcgg ctatattaca atccatcttc 468001 gaagcgccaa tcgaaaatac aaaacagaat acaaagcgca ggaaattgag ctggaaacag 468061 ccctgcaaac aaagcggctc attgctttta tttcagacaa aatcagaatg gatctgacga 468121 aaaactactc tttatatgaa ggcttgattg cccatttgga gccggccgtc agccgcataa 468181 aagaaaatat tgagatatac aatccgatga aggaacagat caagcgcgat tattttctgc 468241 tttatatggc gatcgaagaa ggtgtcgaaa agtattttcc gggcatgtcc ttttctgatg 468301 atgaaatcgc ttttatcgtt cttcactttg gctcggctct tgaaatcaaa aaagaagaag 468361 caaaagtgaa agcgcttgtc gtctgctcaa gcgggatcgg ctcctcgaaa atgcttgcct 468421 ccagactgaa aaaagagctg ccggaaattg aatcgtttga tatgtcatct ctgatcgagc 468481 taaaggggaa ggatgttcaa gcctatgata tgattgtgtc cactgtaccg attccttatg 468541 aaaacattga ttacatcatg gtcagcccac tattaaatga ggaagacgca aaccaggtca 468601 agcagtatat caagcggaag attcccctta ttcttaacaa aaaaagaagc tcgaaggaag 468661 aggcgcagca agctgatgta cctgacatgc tggaggcggc ggaaagcata gggcggtata 468721 tggaagttat ccaagatgtt ctgcgccatt ttacgctagc tcaactcaaa acaaacccgg 468781 accatagcat gcttctgcta gagctttttc aacagctgaa gaaggatggc ctgatccgtg 468841 atccggaaaa agccgcggtt tgcctggctg agcgggagaa acaaggggga ttgggaatcc 468901 ccggaacaaa catggcgctt tatcatctca aaaatgatga aatcgtcctg ccttttttca 468961 aaatgtttga tctcagcacc ccctatgaag tggatggcat ggacggaaat accctcagga 469021 tgacacgcat tctcgtcatg atggcgcctg gctcattatc tgctgaaggc tcggagattt 469081 taagcgcgat cagctcggca attatcgaga gcggagaaag catggcgggg tttcaggaag 469141 aaggaggaca agaattgtat cagcggttaa accgcatatt tttcacatgg atgaaagaaa 469201 aaaacatact gtaaacctgc atggcacacg tcaaaaattt ggcgtgtgtt tttctgtgga 469261 tggggaacaa aataagaaaa tgtgggacta ttttatcatt cagtattgga ataattccaa 469321 aatgaaatag ttttacaagt tatctttttt gggttaaaat gggtgaggta aggaagaaaa 469381 tctaacaaat tattgaagat tcaagagaat ataggagatg acgatatgga aacattacag 469441 catctgattc tgcatgacat gccgaatagc gaagaaatag aggctgtaaa aagcggagac 469501 catacactga catataaagg ttaccgtaaa cggattaatc agctggcgaa tgccatgctt 469561 caaaaaggaa ttcaaaaggg cgaccgtgtt gcattgcttt gcaaaaacgg ccatcccgcc 469621 tcaactgtta tgttcgccgc acttgaaata ggtgctgttg tcgtacctgt cagctggcag 469681 ctgaaaccat atgaaatgac aggcatttta aaagcaagtg aaccaaaagc gatgttttac 469741 ggagcggagt ttaaagagat actggatgaa gttcttcctg aattgtcctc actgtgtgta 469801 acaatggaaa caggaacagc ttacgaaaca tctgctgaat ttgaagcgct gtttgcaggt 469861 cctgatcatt tgccagagac ggaaatggtt tcacctgatg atacagcact tctgatgttt 469921 acatctggaa caacgggaaa cccgaaaaga tgcatgatta cacatggcgg catatacaga 469981 tacgttaaaa aatccaacag ctcaatagca cgtatgaagg gccttcgttt tctcgcgtgc 470041 catccgattt atcatacgag tgcgctcatt tgcatcatgc ttggaacgtt tgcagaaaca 470101 acatttgtgt ttacaaagga tcaagatcct gttcacatgc tgaaggtcat tgaagaagag 470161 aagattcaga ccgtgatggc tcttcctgtg ttctacacgt atttgcttga ggcgtgggaa 470221 aagcaccaaa ctgacttatc ttcgcttgtt attttaatga caggcggaac aaaagtgccg 470281 agcagcctaa taagccgcta tcttgatatt ggcattccgc ttgcgcatgg ctatggaagt 470341 actgaggctt ggggcatcag cacatggacg cctgatatgg gaatggataa agcggcatct 470401 gcaggaaaac ctgtggcagg tgttaaagtc aaagtggaag atcctctgac cggagaagaa 470461 cttcctcaag gagaaatcgg cgaaatcgtt gttcatactc cattcttatt taaaggctat 470521 gaagacaatc ctgaagcaac agcgaaagtg ctgcaaaatg gatggtttag aaccggagat 470581 tcaggatatg tagatgaaga tggctttatt ttcatcacgg gacgctacaa ggatgtcatt 470641 atttacggag gcgataacgt ctatcctgat caggttgaag aagttatcca gcagatcccg 470701 ggaatccttg aaacggctgt ggtcggtatt cctgacccgc tttacggtga aaaaccgaaa 470761 gcttttatcg tgaaaaatgg cggccagcgc atcacggaag aggatgtcat cgcattttgt 470821 aaagaacgcc tgtccgctta caaaatacct gaagttgaat ttgttaacga actgccgaaa 470881 aacaaccttg gcaaggtgaa aaaagacgtc ctgcgcaatc aggctgtaca ttcataaaag 470941 aagaagcccg tccactttat gtggcgggct tctttgcagt tgcacagacg gaaagctcag 471001 gcttaatgtt cttaaattgt atatcaatgt cttcgaagcc ggctgcttta aagtcagcaa 471061 tcatctgtct tccaaatgat ttggttttct caggactggc atccgcttcc cgcggctgca 471121 tcgtaatggc tgctttgccg cctggcttta atgcccgata aatctgtttt atgccttttg 471181 tttggtcatt ccaaatggtg tagttgttaa cggaaatcac tttatcataa aacgaggcgg 471241 ggagaggaaa tgtctcgatg cttccttgta tcaggcgtac gccctttggt ttcactctgc 471301 gggcggccag cttcagcatg gcctctgata catcaatccc atgaagatga acatccttct 471361 cgcgtttcag catctgctgc atgcagtatc ccgggccaaa cccgacttct aaaatgctgt 471421 ccccgcgcgt gatacccagc tgattgattg tccactgatt cagtgtttga ttttcagcag 471481 ccatgatgta cccggcaatc atgccgatga cgccctttgg cctgctgaat cttctagaaa 471541 gcatgttaat cattcagcaa ccaaccccct ttttgagtta atttcctctc agcgttccat 471601 gtgaaacatt tttctgataa agcaatgcga aggtgccaag ccatgtttat ccaaagagtg 471661 tgtgaggtac acaacaaata gacatgaaaa caaaggagga gaatcatcat ggcaaattat 471721 ccaaaagaac tgccggcaca aactcaaagt cgccagccgg gaattgaaag cgaaatgaat 471781 ccaagtccgg tgtatgagta cgaggattat aaaggagcag acaaattaaa aggaaaagta 471841 gctcttatta caggcggcga cagcgggatc ggacgcgcgg tttccgtcgc ttacgcaaag 471901 gaaggcgcag acatcgccat tgtgtataag gatgagcatg aagacgctga ggagacgaag 471961 aaacgtgttg aacaagaagg cgtaaaatgc ctgctgattg ctggtgacgt aggtgaagag 472021 gaattctgca atgaagcggt tgaaaaaacg gtcaaggaac taggcggcct tgacatcctt 472081 gtcaacaatg caggtgaaca gcacccgaag gaaagcatca aagatattac gagcgaacag 472141 cttcaccgca cattcaaaac aaatttttat tctcaatttt atttgactaa aaaagcaatt 472201 gattacctga aaccgggcag cgccatcatc aatacgacat ccatcaaccc gtacgtaggg 472261 aacccgacac tgattgatta tacagcgaca aaaggggcga tcaatgcctt tacaagaaca 472321 atggcgcagg cgcttgtcaa agacggcatc cgtgtaaatg cagtcgcgcc gggtccaatt 472381 tggacgccac taatcccagc tacgttccct gaagaaacag ttgctcaatt tgggcaagat 472441 acgccgatgg gccgtcctgg acagcctgtt gagcacgtcg gctgttatgt gcttctggca 472501 tcagatgagt cctcttacat gacaggtcag accctgcatg tcaacggcgg aaactttgtg 472561 acgacataag agggagtgag acatatgggc atcacgaaag aagaagtgaa cagctactat 472621 caaaaagcag ggattgtatt aacggacgag gaagtagacc aaatccagct gatggattac 472681 ggcttaggaa aagaaagaaa agtcgggctc cagctcttcg tctacgtcaa tacagaccgt 472741 tattgttcaa aggaattggt gctgtttccg ggacagactt gcccggaaca ccgccatcca 472801 ccggtcgacg gccaggaagg caagcaggag accttccgct gccgctacgg aaaagtgtat 472861 ctttacgtag aaggagaaaa aacgccgctt ccaaaagttc tccctcctca ggaagacaga 472921 gaacactata cggtctggca cgaaattgag ctagaaccgg gcgggcaata cacgattcca 472981 ccaaacacaa agcattggtt ccaggccggg gaagaaggtg ccgtcgtgac ggaaatgtca 473041 tcgacgagca cggataaaca tgatatcttt accgatccaa gaatataagg atgggcttaa 473101 cagcccatcc tttttgtatt gaaaaaaaca gaatcatcgc tataatgggt aaaaaaggaa 473161 agagggcgag gcaatgttca cttgcaaggt aaatgagcac atcaccatcc gattattgga 473221 gccgaaggat gcggagcggc tggccgaact cattatccaa aatcagcagc ggcttggcaa 473281 gtggctgttt tttgcggaaa atccaagcag cgctgacacg taccgagaaa caatcattcc 473341 agattggcgg cgccagtatg ccgacctgaa cggcattgag gcgggtctcc tttatgacgg 473401 cagcctatgc ggcatgatca gcctgcataa ccttgatcaa gtgaatcgta aggcggaaat 473461 cggatattgg attgccaaag aatttgaagg gaaaggcatt attacagctg cctgccgaaa 473521 actcattacg tatgcttttg aagagcttga gctgaatcgt gtggcgatct gtgcggctgt 473581 cggaaacgaa aaaagcagag cggttccgga gcggatcggg tttctagagg aaggaaaggc 473641 acgggatggc ttatacgtaa acggcatgca tcacgacctc gtctactaca gtctgttaaa 473701 gcgtgaatgg gaaggcgaaa aataaagagc acactttctt gtttaaatct tccccggatg 473761 tggaaaagta acagcggaga cgttaaaaag gagtgattcg agatgaatca gcaagacatt 473821 aaacaaaaag tgcttgatgt tctagatcac cataaagtag gttcgctcgc aacagttcaa 473881 aagggcaaac cgcattcccg ctacatgact tttttccatg acgggctgac gatttacaca 473941 ccgacaagca aggaaactca taaagcggaa gaaattgaga acaaccccaa tgtccacatt 474001 ttattaggct atgattgtga aggttttggc gacgcatatg tcgaagttgc cggaaaagca 474061 aagatcaaca attcggcaga actcaaggac aaaatatgga gttccaaatt agagcgctgg 474121 tttgacggca aggatgatcc gaatctggtg attcttgaaa ttgaaccgga ggatatcaga 474181 ttaatgaatg ccggggagaa aacaccggtc tcactcgaac tataaaaaat ttgtgttttc 474241 aggggcgata tgttattatg aatagctagt aagaaaaata agcaaataaa aaagaaagta 474301 aacttctttt ttctgttttg agagagaagc ttaccgcttc ccaagcagca taaccagctg 474361 cccttattct tttccttcat aacaaatcgc ccctaacgat gagatggaaa aaagactttt 474421 ttgttttaca attcacaccg gcgcggcttc ggagccgcag tgacgattga gaggtagggc 474481 tttcgttgtc ttgtgttcaa gaaatttcca tggtgtttac tttccagaat gattcttcgg 474541 aacaatgctt tatgaatcta acccgcctga cttggcggat gatataatct ttatttgcgt 474601 atagaaaaga ataagacaaa ccgcccggcg tacgccggac ggttttttta ttgcaaaaaa 474661 cacatcgtac tgaaacctcc ttgtcttctt tccagtctta tctctaggat gaaattggag 474721 gaagaataac gtgcatgtca ttacaacaca agtacttttt attttttgtt ttttattgct 474781 gattcactcg atagaaacct tagcctatgc gacaaggctt tccggagctc gcgttggatt 474841 tattgcgtcc gcgctttctc tgtttaatgt catggtcatc gtatccagaa tgtcgaatat 474901 ggtgcagcag ccctttactg ggcatttaat tgatgatgct ggaaaaaacg cactggcgat 474961 tgtaggggag cagttccgct ttttaatttt cggatcgaca gtcggcacca ttttgggcat 475021 tatcctgctc ccgtcttttg tcgctctttt ttcacgggcg attattcact tggcgggcgg 475081 cggcggctcc gtttttcaag tattccgaaa gggattctcg aaacaaggat tcaaaaatgc 475141 cctttcctat ttgcgtctgc cgtccatttc atatgtaaaa ggatttcata tgcgcttgat 475201 tccgaagcgt ttgtttgtca tcaacatgct gatcacatcg atttatacga ttggtgtgct 475261 ttcggcttta tacgcaggcc ttttggcgcc ggagcgcagc acgacagccg tcatggcttc 475321 gggtttgatc aacggaattg caacgatgct gctggctatt tttgttgatc ctaaggtatc 475381 cgttcttgct gatgatgtgg caaaaggaaa acgaagctat atctatttaa aatggacctc 475441 tgtcacaatg gtcacatcaa gggtggcggg cacactcctc gcccagctca tgtttattcc 475501 cggggcctac tatatcgcgt ggctgacaaa gtggttttaa taagaaaggc tggatcataa 475561 agatccagcc tttttgcgct tccttattta tagttcctta atccgcggtc gtacaaaaaa 475621 tttccgaatg ggacgaaagc ggcgatgaag ccggcagctg accatttcag cggccatttg 475681 acagagaagg ttgcataagc caagacaagc aaatacaaaa tgaacaaccc gccgtgaacc 475741 gaaccgacaa ttgtcaccgc aagcggaagg cctgcccaat atttaagcgg catagcgatg 475801 aacaacagga ttaagagtga cattccttca ataaaaccca tcgtgcgaag tcttccgatc 475861 ggcgtgtgca gcataaatcg ccctccttgt ggacacgttt tcattttata ctataaacaa 475921 tccggggggg catatgacag ctttcaaaaa atgttcggaa aacattcatt tttacatgcc 475981 ttttctaggg aactgtactt gtcatttaca aaaatacccg agataatgtg tacaaaatca 476041 aaaaagaagg atgttgaaat gaaacttgac cagattgatc tgaatatcat tgaggagctg 476101 aagaaggaca gccgtttgtc gatgagggaa ttaggcagaa aaattaagct gtcgcctcca 476161 tctgtaacag aacgggtaag acagcttgaa tcgtttggca tcatcaagca atacacgctg 476221 gaggtcgacc agaaaaaact ggggcttccc gtttcctgca ttgtggaagc aaccgttaaa 476281 aacgcggatt atgagcggtt caaaagctat attcaaacat tgccgaatat tgaattttgc 476341 taccggattg cgggtgcagc ctgctatatg ctgaaaatca atgccgaaag cctcgaagcg 476401 gtagaagatt tcattaacaa aacatcgccc tacgcgcaaa ccgtcactca cgtcattttc 476461 tcagaaattg acacgaaaaa cgggcgcggt tagagagtgc cgcgcgaagt ctgttataat 476521 aacaggatga gcgtgaaaga aagagaagtg atcaagcatg tcaaaaacag ttgtattagc 476581 tgaaaaacct tcagtcggcc gggatttagc ccgggtactg aagtgccata aaaaaggaaa 476641 cggttatctc gaaggcgatc aatatattgt gacttgggct ttaggccatt tggtgacgct 476701 tgctgatccg gaaggctacg gaaaagaatt tcaatcatgg cgcctagagg atctgccgat 476761 tatcccagaa cccttgaagc ttgtggtgat aaaaaaaacc ggaaagcagt tcaatgcagt 476821 caaatcccag cttacccgta aagacgtcaa tcagattgtc atcgcgactg acgcaggccg 476881 ggaaggtgag cttgttgcgc gctggatcat tgagaaagcg aatgtccgaa aaccaatcaa 476941 gcggctgtgg atttcatctg tgacggataa agcgatcaag gaaggttttc aaaagctgcg 477001 cagcggcaaa gaatatgaaa acctgtacca ttctgccgtc gccagagcgg aagcggattg 477061 gattgtgggg atcaacgcca cccgtgcact taccacaaaa ttcaatgccc agctctcatg 477121 cgggcgtgtg cagactccga cgcttgccat gattgcaaag cgcgaggcag acattcaggc 477181 gtttacgccc gttccgtatt acggcatacg tgctgcagtc gacggcatga cgctgacgtg 477241 gcaggataag aaatcaaagc agacgagaac gttcaatcaa gatgtaacaa gccgtttgct 477301 aaaaaatctc caaggaaagc aagcggtcgt agctgagctg aaaaaaacag cgaaaaaaag 477361 ctttgcgcct gcgctttatg atttaacgga gctccagcgt gacgcccaca agcgcttcgg 477421 tttttctgcc aaagaaacgc tttctgtcct gcagaagcta tatgagcagc ataagctcgt 477481 cacatatccg cggacggact ctagattttt atccagtgac atcgtcccga cgttaaaaga 477541 ccgtctggaa ggcatggaag taaaaccgta tgcccaatat gtcagccaaa ttaaaaaacg 477601 cggcattaaa tctcataaag gatatgtcaa tgacgcgaag gtgtcagacc accacgcgat 477661 tatcccgacc gaagagccgc tcgttctcag cagtctgagt gataaagaac gaaagctgta 477721 tgacctgatt gcgaaacgtt tcctggctgt attaatgcct gcattcgaat atgaggaaac 477781 aaaggtcatc gcagaaatcg gcggagaaac ctttacggcg aaaggcaaaa ccgtgcagtc 477841 gcaagggtgg aaagccgttt atgatatggc ggaagaggat gatgagcagg aggatgacag 477901 agatcagaca cttcctgcgc ttcaaaaagg cgacacactt gccgtccgca cgttaacgga 477961 aacaagcggc caaacgaagc cgcctgcccg ctttaatgaa gggaccttgc tgtcagcgat 478021 ggaaaaccca agcgcgttta tgcagggaga agaaaaaggc ctcgtcaaaa cgcttggaga 478081 aacaggcggc ctcggcacgg tggcaacgcg tgccgacatt attgaaaaac tgttcaacag 478141 ctttttaatc gagaaaaaag gccaagatat ttttatcaca tctaaaggaa aacagctcct 478201 gcagcttgtt ccggaggatc tgaaatcacc ggccttaaca gcagaatggg agcaaaagct 478261 gtctgcgatc gcggccggca aattgaaatc ggctgttttt attaaagata tgaaggctta 478321 cgctcaccaa acggtaaaag aaatcaaaaa cagcagccaa accttccgac atgacaacat 478381 tacgggaacg gcatgtccgg aatgcggcaa aatgatgctg aaagtaaacg gcaaacgcgg 478441 gacgatgctc gtgtgccaag atcgtgaatg cggaagcaga aaaacgattg cccgaaaaac 478501 aaacgcacgc tgcccaaatt gccataaaag aatggagctt cgcggccaag gcgagggcca 478561 aacctttgcg tgtgtgtgcg gtcaccgtga aaagctctct gtatttgaaa aacgaaaaaa 478621 caaagacaaa gcgcgtgcta ccaaacggga cgtatcctct tatatgaaaa aacaaaataa 478681 agatgagccg attaacaacg cgctggcaga acagctgaaa aaactcggtt tggataaata 478741 ataaaaaaac ctgtgcctat cgcacaggtt ttttattgga cttaggtcct gttttcttaa 478801 tgttcaaaaa gggaaaaaaa agctagcaat ctgcattttt tttcttttat agtaaatgta 478861 ctttgtaaca tggcagtcat attttcgtct ataactattt gtgagcgtct gatttgcttc 478921 aggcgacaaa gggggatttg cctgtgaggc atgtactaat tgctgtcatc ttattcttct 478981 tatctatcgg actttccgca gggtgtgctg aagctggaaa caagacccaa aatcagtcgg 479041 cgacagaagt gaatgccagc ccgctccagc cggcggaata tttcatctat cacaatttaa 479101 tgaatgacaa agggctgatc aaaaccgatt tttcagacca gccttcttac ttgtcggaat 479161 ctctcggact gtggatggag tttctgctca gcaaaaatga cgcaccacat ttccaggatc 479221 aatatcagca tctgactgat tcatttctga tgagcaatca cttggtgacg tggaagattc 479281 aaaatggcca agcgagcggg acgaatgcgc tgatagatga tatgagaatt atgctgtctc 479341 ttgaccaagc cgccgcaaaa tggggccgca gcgactacgc gcaaacggct agggatatcg 479401 gcacgtcttt gaagacatac aatatgaaca acgggttttt tacagacttt tacgactcac 479461 aggccgcttc aaaggatgtg acgctttcat acgtcatgcc tgatgcctta gctgtcttaa 479521 agaagaatgg aatcatagac gaagaaacag aacagcggaa tgccaatgtt ctctattcag 479581 ctcctttaaa aaatggcttt ctgccgaaga catacagctc ggagacgaag gaatacacat 479641 atgatagtga aatcaacctg attgatcagc tttacgctgc ttggcatttg ccggaagggg 479701 atgaaaaagc atctgtttta gcggactgga tcaagcagga atttcagaaa aacggaaagc 479761 tgtacgggcg gtattcggca tatacgaagg agcctgccgt ccaatatgag tctccatccg 479821 tatatgcctt agccgtattg tttttgacaa aacagcatga aaacagttct gtcatcaaag 479881 ccatatatga tagaatgaat gactttgaaa ttcatgatcc ggtgaaatcg tattatggag 479941 gctatatgag cggcactcag acgcattcat ttgacaatct gctgccgctg ttagccgaaa 480001 ggaagctttt taatgaaaat atcattcagt gaatcacaaa aattatttgc ttatttttca 480061 gggctcatcg cggccctgtc tttgtttatt tattatgtgt cagcccagca atcagaaggt 480121 gctctgatcc tttgcatcac atttggcgtc atcgccgcag gcatctggtt cggcccgatt 480181 tacgcgctgg cagtgacctt aatcgtactc tttgttctcg gcaccttaat gatgtttttc 480241 cagactggac agacatcgct ctttccggct gaggaagggc tgcgaatgct tgtcgtgtgg 480301 ggaatcgcgc ttttgctgtt ttcttttatt tctggaagaa tccacgatat tacagcagag 480361 cttcggcgct caatgacacg gcttcaatcc gaaattaaaa gctatgttgc tgttgacaga 480421 gtgactggtt ttgataacaa gcaaaggatg aagctggaac tttcagaaga aatcaagcgg 480481 gcggagcgct acggcaattc ttttgtgttt ttgctgctcc atatgcatta tttcaaagag 480541 tttaagtctt tgtacggtga aaaagaaacg gaccgcctct tccaatatgt cggtcagcaa 480601 atcaggacaa gcgttcggga aacggataag aaattccgtc cctctgacga gcgtatcggg 480661 atcgtgctga cgcacacgcc tgctgaacat atgccggccg ttctgactaa gctgaagaaa 480721 caattggata catatcagct ggaaaatgga aagtatgtgt cgcttacgtt ccacgtttgc 480781 tatttgccct accgcaacga tatccaaaca gctgatcaat ttttagaaga actggaaaac 480841 gagatgatga tgaatgaact ataaaggaat cacattgcta tgcgtcatga tgcttctatt 480901 ttcagctatt gcgtcttttc ccgtttctgc gcaagcgaaa gatcaggatg ccggcattct 480961 catcatctac tcaaccttgg acggcaaaga gtcgtcacaa gtcaaaatgc tcgatttgct 481021 tgcgggccac tttacatccc atgtgacagt caaaaaagat tcagacgttg aagcgtcgga 481081 tttcaaaggg aaagaccatg tgatttatta cggccaaacg aaaagaaagc tcagccaaaa 481141 attgctgtct cttatcagcg gcgtgaaaaa accggttgtc gccattggct ataacgcagg 481201 ccaaatcagc caattttctg ggctttcatt agcccgcaaa gaaaatgtgt ttcaggttca 481261 cagcaggtca gaaaaggccg atgtgtctct ggaaagcggg cttaacgtgc tgagtgtatc 481321 aggcctgaaa ggaacggcgc tttacacctt caaagcggat gaaggcacaa cgcattcttt 481381 tatatggaaa acaaaaaaag ggaatgtgta cattggatta acaaatttgt taaatgacaa 481441 tttgatcgtg gcgaaacagc tcagagaagc tttcggagag aaggcgggga cgacgttatt 481501 gtatttgcgt ctcgaggata tcagcccgat gtctgatgaa aaactgctgc ttcaagccgg 481561 tacatacctg cataagcggc atattccttt tatcctggcg gtcattccgg tttacttgaa 481621 tccggaaaca ggcgacaaag tgtatttgtc taatcaaccg aagatggtca aggtgctgaa 481681 gaagctgcaa agcatgggcg gcagtatcat agttcacggc tatactcacg cttatcgcta 481741 cagtgaaaca ggagagggat ttgaattttg ggatgcaaag gcggatcagc cgattacatc 481801 cggaaatgcc gaagaccccc cgtccatttt ggagaaagaa caggacttcc cgaacgaaca 481861 agcctatcac agctatcttg aaccatttcg ggaaaaggaa gaaacgtata caaaacaaaa 481921 actgacgcgt gccattgagg atttgacatc atcgggtctt tacccgctgg cgtttgaagc 481981 gccgcattac acgatgtccg aatatggcta tcaaatcgcc tcgcagtatt ttacaagcat 482041 tttcggccag gtccagctca gcagcacaac atggaaaaca tccggtgcac ctccgtttgt 482101 gactgctcct tcgatgctgc acggaatgac gctttatccg gaaacgatcg gctttgtcga 482161 cacatcgaag caaaacccgc tcggtgagat ggaggagcat atctcccaga tgattgattt 482221 tgaaggcgga gtagccggag gattttatca cccgtacctt gggatgaaat atctgcctga 482281 gctggttgat cagatggaac gcattccaga cagtgaatgg cttgatttaa agaaaacgaa 482341 acaaaccgtc aaaacagaca aagtggaaat tcatacaagc ggtgacggaa cgattcaggt 482401 gaaaaacggc gtaagcccca tttacgagtt tttcgatcat caccggcaaa cccctctgga 482461 aaaggcgtta tggattctct ccgctgttgt gctcttattt gtcatcatgt ttgtcagtta 482521 tacgttttac ttgagagcca cattgaaaaa acgaattttt aaggagagaa gaagccttgg 482581 gtaatacgct gttctttatc tcgctaagtt taatatgggt tatgcttctc taccacatgt 482641 tcctcatgca gggcgggttt cgccactata tgaccttcga acggaatatc ccgaagtgga 482701 gagaaaatat gaaggaactg ccgaaggtca gcgtcctcat cccggcgcat aacgaagagg 482761 ttgtgattcg gcagacgctg aaggccatgg tcaaccttta ttatccgaag gaccggctgg 482821 agattatcgt cgttaatgat aattcatcag accggacggg tgatatcgtc aatgaatttt 482881 ccgagaaata cgatttcatc aaaatggtga ttacgaagcc gccaaatgca ggaaaaggaa 482941 aatcctctgc acttaactcg ggttttgccg aatcgaacgg cgatgtgatc tgtgtgtatg 483001 acgccgacaa cacgcctgag aaaatggccg tgtattacct cgtgctcggc ctgatgaatg 483061 acgaaaaggc aggcgccgtg gtagggaaat tccgcgtcat caatgcggca aagacgctgc 483121 tgacgaggtt tattaatatc gaaacgatct gttttcagtg gatggcccag ggaggcagat 483181 ggaagtggtt caaaatcgcc acgatcccag gcaccaactt cgcgatccgc agaagcatta 483241 tcgaaaagct cggaggctgg gatgacaaag cgctcgctga ggatactgag ctgaccatcc 483301 gggtatataa tctcggctat cacatccgct ttttccctgc cgccatcacg tgggagcagg 483361 aaccggaaac atggaaggta tggtggcgcc agcgcacccg atgggcgcgc ggcaatcaat 483421 atgtcgtgct caaatttttg gcgcagtttt ttaagctgaa acgaaaacgg attatctttg 483481 atttgtttta ttttttcttt acgtacttcc tgtttttctt tggcgtgatc atgtcaaatg 483541 cgatttttgt agtgaatttg ttttatgatt tgcatttgtc tgttggattt ttggcaatga 483601 ttctctggat tttggcgttt ttcttattta tgacagaggt catgattacg ttgagcattg 483661 aaaaaacaga aatgaacaag caaaactttt ttatcgtatt tctcatgtac ttcacatact 483721 cgcaggcatg gattgtgctt gttatctact ctttattcgt agaaatcaag caccgtttat 483781 tcaagcaaga ggtcaaatgg tacaagacag aacgatacaa tcaacataaa agcgggtgac 483841 ctttttgaaa caaataatga tttttctcac aagcttcatg ctgctggcga tgactggaca 483901 aacggctctt gccaaagacg tacaggtcag cggttcgctc cttgggaaaa gcagccaaga 483961 acaagccaaa cagcaggtgc tgacaagcga gctgattaca ctgtatggat caaaagacag 484021 cgcagagctg acgtatcaga tcccggcagg cgcctcttcg ggcaatcagc aattggtaat 484081 cgaatacgag gcatcaaatc ttttaatttc tccatcatcg ttaacggttg tcattgatga 484141 tgaaccggtc aagacgttaa agcttgatgg tgattccaaa cggaaaacag tgaagctgaa 484201 tctgaataaa agccagtctg cgcaaggcta tcacaacgta tcgctgaaat tctacggcgt 484261 aatgaaagag ggcgtgtgcg tcagacagga tacatcaggc aactggatca aaatttatcc 484321 ggacagccgg ctgacacttg ctgacagcag tgaagcgaag ggaacgtcgc tggaccatta 484381 tccgtatcct ttcgcccaat ctggaaatac agcggaagaa acagctatcg tcattccgga 484441 taacccaagt tcagcagaaa tagaagctgc tgttaaaaca gaaggctatt tgaaaacggt 484501 ggacagcagt gtcagtattg cgtatgtcac ggaatctgaa ctgaaaaaaa tcgataagcc 484561 gacgattgtt atcggcgtgg acaagcattg gaacggcaaa gtgaaaaaac tgttgaaaca 484621 agccgggcta caggcaaaag gagaaaacct tctgcttgcg gagcgggtgc tgaaagcaga 484681 gggcaaacag cagccggttc tgtttgcgca agcggcgtcc gaggacgcgc tcacaaaaaa 484741 aatcagcgtg atgacagatc agacatatac aggccagctc agcggcgata cactttcaat 484801 cagcaagctt cagcagactg aaaaaaaaga aagcgataag ctgacccttg agaattttgg 484861 agcgggtgat atcacaattg gagccgacaa aacatcttca gcacattatt tttatccggc 484921 ttcggctgtt ttagatgaaa accaatcggc gaagctgtcg cttaaactga aaaagtctga 484981 aacgattcaa gcctcaacgg ctgaaaacga gtcagcctct caggctgcag aactgaaagt 485041 gatgatcaac ggccagccgc actcggtccg gcttgatgaa ttaggaaaag aagataaaaa 485101 cggattctat catgtcacag tgaaagtgga ccctaagctg ctgcaaaaaa accgctacat 485161 tgatattcag ttcgtcacga ccggtttaaa ggaaaacaac ccttgtaaca ccactgatga 485221 agaaaagtgg gtttttatcg ataaaaacag tacattatca tacgccatca aaggcatgtc 485281 cccgtcagcg gattttcaag agtggccgct gccttacgcc ggaaaccagg atcaaacaac 485341 gttaatcgtg cttcctgaca ccgtaagcca atcgaagcta gaggagcttt ctctcgtaac 485401 agaatccttt ggcaacgaag cacagcattc atatacggta aagaaatcat ctgacgttac 485461 agcaaatgat gcgaaaggac gaaacctcat tttcatagga gggatcaatc aattttctct 485521 tctgaaggag aaatcatcag atctgcttgt gccgcaggaa aagaacggct cgtttgatgt 485581 atctagtttc gagatgctga atgagacgac aaaacaagtg gtatttaccc aagcatcggt 485641 ttgggattca cgctatacaa tggctgtctt tgcaccgtca aaaggagatg gcacggctgt 485701 cacaaaagag atcatcagtt atctgaacag caacgatgag tcggcaaccg tccttaatga 485761 aacaaacagc cagcaggtgt ttacaaacca ccagcagctc aaatcggaaa caaacagttc 485821 cgatgcagaa caaccaacac aggatcatag ccagaaatgg atgtatattg gtgtgctggc 485881 actcattatg gtggttgcgg cagtgttcat ttggattgcc gtaagacgca aaaaaagaaa 485941 gacagataca gaataaaaca gaggcgattt tagcctctgt ttttttattt ttggtaagta 486001 aattccattt gtggaacctg tcattttatt tttttctctc agccaataag cctctttaca 486061 acgtgcggga acgggagtat gatctctttt agaaaacaaa tcgcttaatc tgaaatcaga 486121 gcgggggacc caatagaacg gctttttgcc gttggggtga atccttttta ggtagggcta 486181 actctcatat gcccgaatcc gtcagctaac ctcgtaagcg ttcgtgagag gagatgaatg 486241 aaacctgtgt tcgatgttat ggcacagggg catccgtttg cctctgtgtt ttttgttgtt 486301 catttttgaa tgcaaatcgc atacagagac atcatagcag aaaggactat catcaacatg 486361 tgagagcaag acactgatgg atgttttatt gttttaattg aaaaatgaga aattaaaagg 486421 ggaagacatc gatgtatcat tcaatcaaac gttttttgat tgggaaacca ctaaaatccc 486481 aagcagctgg agagcaaaaa ctgacgaaat taaaagcctt ggctatgctt tcctcagatg 486541 cgctgtcatc tgtcgcatat gggacagaac aaattctaat cattttggca acaatcagtg 486601 cagccgcatt ttggtactcc attccgattg cggttggcgt tctcatcttg ctgctcgcac 486661 tgattctttc atacaggcaa attatttacg cttatccgca gggcggcggg gcgtatatcg 486721 tttctaaaga aaatctcggt gaaaaaccgg gattgattgc gggcggttca ttgcttgttg 486781 attatatttt aacagtagcg gtaagtattt ccgcaggcac ggatgccatc acgtcagcct 486841 ttcctgcatt gcatgattat catgtgccga tcgctatttt tctcgtgtta gtgattatga 486901 ttttgaacct gcgcgggctt tcggaatcag catccatact tgcctacccg gtttatctgt 486961 ttgtggtggc gcttttggtt ctcattgcag tcgggttgtt taaacttatg acaggacaaa 487021 tagaccagcc agcccatcat acatcgctcg gcacacctgt agccggcatt acgctatttt 487081 tgctgcttaa ggctttttcc tccggatgct cagcgttgac cggggttgag gccatttcta 487141 atgcgattcc tgcattcaaa aacccgcctg cgcgaaacgc ggcaagaacg cttgcgatga 487201 tggggatttt gctggcgatt ctgttttccg gcatcacggt tctcgcgtac gggtatggta 487261 cggcgccgaa acctgatgaa acagtggttt cacaaattgc gtccgaaacc tttgggcgga 487321 atgtgttcta ctatgtcatc caaggtgtca catcgcttat tttggttctt gcggcaaata 487381 cgggattctc agccttcccg cagcttgcct tcaacctggc gagagaccag tatatgccgc 487441 gaatgtttac agtcaggggc gaccgcttag gcttctcaaa tgggattatc tttttaggct 487501 ttgcctccat tgttctcatt atcttattcg ggggacagac ggagcactta atcccgttat 487561 atgctgtggg cgtatttatt ccatttacgc tttcacaaac cggcatgtgc atgaaatgga 487621 tcaagcaaaa accaaaaggc tggatcggaa aaatgctgat caactcctgc ggcgctctga 487681 tatcatttat ggttctatcc attctgtttg tgacgaagtt taatgtcgta tggcctgtgt 487741 taatctttat gcctatcgtc gttttgctgt tttttgcgat taaaaatcac tatactgcgg 487801 ttggtgaaca gcttcgcatc gtagacaaag agccggaaga aatcaaaggc accgttgtga 487861 ttgtgcctgt ggccggtgtc accaccgtcg tgcaaaaatc gattcactat gcgaaatcac 487921 tgtccgatca ggtgatcgcc gttcacgtgt catttgacag agaacaggaa aagaaattcg 487981 aaaaacgttg ggaagagctt aataacggag tgcgtctcgt gacgcttcac tcctcttaca 488041 gaagccttgt ccatccgttt gataagtttt tggaaacagt tgaggcaaaa gcgaagaagg 488101 agcagttttc cgttatggtg ctgtttccgc aatttataac gaaaaaacgc tggcacacca 488161 tccttcacaa ccaatcggcc ttcctcctca gagtccggct gttctggaaa aaggacataa 488221 tggttgccac actgccgtat cattttaaaa agtaaagctc taggaccaag ggaatcacct 488281 tggtcctttt tagcgggaaa aggaggtatg ggggtgtata cacaaggtgc ttttgtgatc 488341 gtattgaacg aaagtcagca aattctgctg gtgaaacgaa aagatgtccc tctatgggat 488401 ttgccgggcg gcagggttga tcccggggaa tcggctgagg aagcggcagt gcgggagata 488461 ttggaagaaa cgggatacaa tgcagcgctt tctgcgaaaa taggtgttta ccaaaggcca 488521 aagtttcaag atgaacagca tctgtttttc ggaagcatta caggcggaca agcaatggct 488581 gacggcacag agacagcggg attaaagtgg gtttccccgg ggcgtttgcc gctttttatg 488641 gtgccgaatc gaaaaaggca gatcaatgat ttcaagaacg gcgctcaaga tgtaaatgtc 488701 accgtcaagg atagcgggtt gctcgcggcg atcgacctgt tgaaaagaag actgggcaag 488761 tgattcaggt ctccgggttt taaagccttt ctcctgtggt attgaaaaaa ggaaaaagga 488821 ggatacgtta tggcacacaa aactgcagga caagcaatga cagagctgct tgagcaatgg 488881 ggagttgatc atgtatacgg catccccgga gacagtataa atgagtttat cgaagaatta 488941 agacacgaaa gaaatcaact gaagttcatt caaacccgcc acgaagaggt agcggcactg 489001 gcagccgcgg ctgaagcaaa actcaccggc aagatcggag tctgtctgtc aatcgcaggg 489061 ccgggagcgg tgcacttatt aaatggttta tatgatgcta aagccgacgg cgcccctgtg 489121 ctggcgattg caggacaggt ttcttctggc gaagtcggac gggactattt ccaggagatt 489181 aagctggagc aaatgtttga ggacgtggcc gtgttcaaca gagaggtaca tagcgcggaa 489241 tcacttccgg atctcttaaa tcaggcgatc aggaccgcct acagcaaaaa aggcgttgcg 489301 gtattgagcg tgtcagatga tttgtttgcg gagaaaatca aacgggagcc cgtgtatact 489361 tcaccggtgt atattgaagg gaacctagaa ccgaaaaaag aacagctcgt cacctgcgcc 489421 caatatatta ataacgctaa gaaaccgatt atcctggcag ggcagggaat gaaaaaggcg 489481 aaacgggagc tcttagaatt tgcggacaaa gccgccgctc cgatcgttgt tacactcccg 489541 gcaaagggtg ttgttcccga taagcaccca cattttctcg gcaacctcgg tcagatcgga 489601 acaaagccgg cttacgaggc aatggaggaa tgtgatttat taatcatgct cggaacgtca 489661 ttcccgtacc gtgattattt gcctgatgac acgccggcga tacagctcga ttcagacccg 489721 gcaaaaatcg gaaaacggta tccggtgaca gcgggccttg tctgtgattc ggctctcggt 489781 ttgcgcgaat tgacagagta tattgaacgc aaggaagaca gaagattcct gaatgcctgc 489841 acagaacata tgcagcattg gtggaacgaa attgaaaaag atgagacaga ggcaacaaca 489901 ccgcttaaac ctcagcaggt cgtggcccgt cttcaggaag cggcagccga tgatgcggtg 489961 ctctctgtag atgtcggcac tgtgacagtc tggatggcgc gtcatttcaa aatgaacgcg 490021 aatcaggatt tcatcgtttc cagctggctt gcgacaatgg gctgcggcct gccgggagcg 490081 attgcagcga gcttgtccga accggaacgc caggcgatcg ccgtctgcgg tgacggggga 490141 ttttccatgg tcatgcagga ccttccgacc gccgttaaat ataagctccc gatcacagtc 490201 gttattttaa acaacgaaaa tctcggcatg attgagtacg agcagcaggt caaaggcaat 490261 atcgactatg tcacaaaact tcaaaatgtc gactatgccg catttgcaga aagctgcgga 490321 gcaaagggca tcaaagtgac caaagcggaa gagcttgcgc cggcttttca tgaggcgctg 490381 cactctgacc aaccggtcgt agtggatgtc atgattggaa acgaaccgcc gcttcctggc 490441 aaaatcacct acgggcaggc gaaaggcttt agcaagtaca tgctgaaaaa cttcttcgaa 490501 aaccaaaaat ttgaaatgcc gtcactgaag aaaagtttga aacggttatt ttaaaaaaac 490561 aggggcccta agagcccttg tttttttttt tttttttgga aacaaatgta ttttcagcat 490621 gtttgaattc ataaaatgat cggtatatgt attaggaact gatttcgcca tactcgaaac 490681 agacaaaagg acaaatgcat cttgtttcaa aggaagatgc atttgtcctt gcatgcttat 490741 tcttatcaaa tcttacagaa ctcttctcat aataggttat ttttcttttt tcttcagccc 490801 gaagaagaaa ggaaaagcag aaccgaccaa gaaggtgccg aataaaaaca tgccgccgat 490861 aaacacgtgg aaatttgtgt gtccggccgt aaacgccgtg attagggaaa tgatactgag 490921 cacgatcatg gcaatgccgg gcgcgactct catttttccc ttggatttat gggcagcaac 490981 agaacataaa atgccgataa caataggaac aatccacaaa taaaacagaa taaatactga 491041 catcatcaaa actccgattt ttcttctatc ataacaaatt tctgtcaaaa agggtatcaa 491101 tgagcttttg cggaaaaata aaaaccggct ttagaagccg gtttttttat cgaaacgtat 491161 ctacaattaa aaacacattc aaagcaacga tcaatacagc aatcagccaa gacaccactg 491221 tgatccattt ggcgttgatc agagatccca tgatccgttt attgcttgta aacataataa 491281 gcggaatgag ggcaaaggcg atcccgaagg acagcacgac ctggctcagt acgagagcgg 491341 tcgtcggatt aacacctgac gcgatgatca agatcggcgg aatgatcgtg ataaaacgcc 491401 gtacatacag cggaatgcgg tagttgataa atccttgcat aatcacgtcg cctgaaagtg 491461 tgccgacaga cgaactggat agaccggcaa cgagcagccc gatcccgaac aaagccgcag 491521 acatagggct gacaagatgt ccgaattgct gaaatgcgac gtcgagatcc tcaacaaaca 491581 ggccgttttt gaagaataat gcggcagcca caatcagcat acttgcatta atagcccctg 491641 caatcagcat cgctattaaa atatcaataa attcaaacct aaagattttt ttccgttctg 491701 catcagtttt gccaaccacc cgccgctgtg taagggcaga gtgtaaataa atggcgtgcg 491761 gcataacagt tgcgccaaga atacccgctg caagaagcac actgtcggtg ccatgaaacg 491821 ccgggacaaa aaggcccttc atcactgaca cggcatcagg ctttgcgaaa aaggtctgca 491881 acgcaaaggc gatcacgacc acaaacagca taccggcaat acctgcttca agtgagcgat 491941 aaccacggcg ctgaagctcc aatatcgcga aagaaccgat cgccgcaata atagacgctt 492001 caagcatcgg aatgccgaac agcaaataca gtcccagagc cgctccgata aattccgcca 492061 gatcagttgc gataatgacc aactcgccct gaatccataa tccgatcgag acaggcttcg 492121 ggaattcttc acgggcaacc tcaggcagat ttttgcctgt cgcaataccg agtttggcgg 492181 atagggattg aattaaaagc gccatgatat tggaaaataa gatcacccat aagagcatat 492241 atccgtattt agaacccgcc gaaatattcg ttgcgaagtt gccgggatca atataggcaa 492301 tggctgctat aaatgcaggg ccgagaaaag ggagcagccc tctgaatcct ctgattttcc 492361 cgtcaagcgc atcttggacg gctttggaac ggggagattg tgctgtgatg tccttgttca 492421 tcatgtctca cctgaattct gtttgttttt gccgtacaac aaagagtttc cttaaggcaa 492481 attattttat ctacatcata tgaccatccc ggtttcttgt caaccgaaaa tgttcaaaat 492541 acacttctga atttttccct gttatgtaac atgatatgta gggattcgtg ataaggtccc 492601 atataaaaag acatcgtttc atttcgaaac gatgcctcct gtatctaatg agtctaggct 492661 tccttccgca gcccgcggaa tataaggccc agcaagaaca cgaagatggc tgccccgatg 492721 atggccggga aaatagcaaa gccggcgagg ctcggtcccc atgtgccaag aagtccgtgc 492781 ccaatccaag cgccgatcag cccggcaatc atagagccga aaattcctcc cggcagccgg 492841 tttcctacaa tggcgctccc aattaatccg ataacaattg caacaactaa tgaaaccaaa 492901 aagctaagca tcatgatcac ctctcataaa tgatttacca atcaataacc gctcctgatc 492961 atttcgaaac acttgaaagc atattccttt atgatcctgt tttaatcttt ctctgcacac 493021 tgccgtcagc taaatgaaca atgacctcag tgcctttatg cgccgcgatt tcctttgccc 493081 gttcaatcgc ttctttcttt gtatccttga tttcagacac acgtttggcg ccctcggctt 493141 tgactgccca gcctttttta tgcttaataa catgctctgc tttattcatg agctcggggc 493201 cgctgccgct gcttggatca gcatcgcgtt ctgtctcatc atcatgcgtc aggaaatcat 493261 caatttcatc tgtagaggcg ttttccgccc attccttcgc tttgcttgtc gcaattggaa 493321 tcgcgcgccc ttcctcatag ccttcatcaa tcatcgcatt cgcaatgtct atcgcctttt 493381 ttctcaccgg cttctcaaga ttttttaatg aagcaggata atccttcatc gaccaaggca 493441 tgtctatcac tccttttcct tttataaaaa tggtacccgc aggtgaaaaa taaaaacgca 493501 tccgaaaaaa tgaaggtata ctatatagta gaaaaaacgg aagggaagtg cgggttgggt 493561 gccaacagaa cgaaaagaag acttacatca gcaattaaaa gagatagaga aatgggaaaa 493621 agatcagcaa aaagtctggt tttgggaaaa gctcagccgt ctcccgtttc aactcctgga 493681 caagctgaca ccagaattca tccagaaaaa gatcggcaag ctcttggatg aggtcggcag 493741 ctttgttcaa acaggcggac agtacctgac atctgaaaaa cagattatca ggatgtttca 493801 aaagaaactg ccggaggaga tctttgaatc gctggaggac atccggaaag cgcctcttcc 493861 tgtcatggat gaaattgcgg aaggaatggg caaaaacaga accaacgcag caaccgttca 493921 aggcgcgaca accggtgtgg gcggcgtgtt tacgctggcg gcagacattc cggcagtgct 493981 tggcttatca ctaaaaacat tacaggatat cgcagtcgca tacggctatg acccaaagga 494041 gaaaaaagaa cgagtcttca ttgtgaaatg cctgcagctt acgtcggctg atgttgtcgg 494101 caaaagatcg attttgcagg aattaaaaca ctacgatcaa gaccgtacat ataagaatgt 494161 cgcttctcaa atccaaggct ggcgagaagt cgttttgggc tatcgagaca cgtttggctg 494221 gaaaaaactt ttccagatag tgccggttgc cggaatggtt tttggcgccg ctgccaatcg 494281 ctcaacatta aacgacatta ccgagacagg catgatgctg tacaaaaaga ggcgcattct 494341 tgaacgactg aaagaaacag aacgagagat ggaatagcag aaagcagacg gacaccgcga 494401 tccgcctgct ttttttagtg gaaacatacc caatgtgttt tgtttgttta aaagaattgt 494461 gagcgggaat acaacaacca acaccaatta aaggaggaat tcaaaatggc agacaataac 494521 aaaatgagca gagaagaagc aggtagaaaa ggcggagaaa caacaagcaa gaaccatgac 494581 aaagaattct atcaagagat tggtcaaaaa ggcggagaag ccactagcaa aaaccatgac 494641 aaagaattct atcaggaaat cggcgaaaaa ggcggagaag ccactagcaa gaaccatgac 494701 aaagagttct atcaagaaat cggtgaaaaa ggcggagaag ccactagcga aaatcatgac 494761 aaagaattct atcaagaaat cggccgaaaa ggcggagagg caacaagcaa aaatcatgat 494821 aaagaattct accaagaaat tggctcaaaa ggcggaaacg cccgcaacaa cgactaatca 494881 aaagcataaa ggcagacaac ctgtaaataa aaaagcgatc cggcacatca gctggatcgc 494941 ttttttttgg aatcttctca atttatgccg ctattgagat acaataagtg aaaaaggggt 495001 tttcgctaat gtccaagatg caaaacttgc tcgccatcgc aaatgaagtc aaagaaaagc 495061 acgccaattt ttcaatctca gaggtcaacg accactgcgt gcgccttgcg gtgtttacgg 495121 gagaatatga ctggcaccat caccctgact cagacgaatt gtttattgtt cttgaagggg 495181 agctgctgat cgattttaag gacaaagaaa ccgcggtgct caaagcaaat gacagcctgc 495241 tgatccctaa aggcacggtt caccgcacac gctcttacgt cagaacggta aatctctgtg 495301 tggagcataa acaagccgaa accgtcatca tagaggagca gccatgctaa tcaaaaagat 495361 gatatgtgaa gtagatgctg caaacgctga agcatttgca aaagcgcagt cacagtggga 495421 agcgttatcg catataagcg gctttatcaa acaggccggc ggctggcgaa aaacgataga 495481 cgagccgctc accgcagaaa tcatcagtgt atgggaaaac agagaagcct atgatcattt 495541 tatggagaac gaacatgaca gcatatacga ggaaaacgat cagaaggctg taattctttc 495601 gatagaggtg acggtgtacg aagaggataa accgttcgtt cacgatctgt tacataaccc 495661 cgatatccgg tacgaaccaa actggacggt tctgaaggca taatcaaagc ccaaaacatc 495721 atgttttggg cttgtctctt tactcgcgtc ccggaagtgt attatgaaca aaaggcggtg 495781 ctggttttaa ctccggtttt tctccaaacg tttttgcttc tttcacatat tcaaaggctt 495841 ctccgtccgg cgctttttca ttcagccagt tttgctcggc gcttacttcg ccttcagaga 495901 aattgataag ctgatgtgag aactcttgtt tttcgagcgc tttcgggaat gtacccggca 495961 caaccggacc ttcctgtgct tctaattctt taatggcggc gagccattgg ttctggtgca 496021 tcgtgtcacg cgccagcagg aagctgagca tatctttgac gcctttgtca tccgtcattt 496081 caaacaggcg tgcgacctgc agacggccct gagattccgc attcaggttg gcgcggaagt 496141 ctgccagcag gtttccgctt gctacgatat aaccgccgct ccaaggtacg cctgtactgc 496201 tttccggcat ggcgccaagt cctgatacaa tcgcatggtg agggttcatg ccgcctagga 496261 tggagccgat gaccggatct tcagcagctt tttcctgctg atcaagaggg gcatcctcaa 496321 gaagtctggc aatcatcgtt gcgatcattt caacatgccc gagctcctca gttgccgtat 496381 ccatcagcaa gtccttgtat ttttcatttc ctcttgtgtt ccagccttga aataagtact 496441 gcatggcaac tgaaatttct ccgaattgcc cgcctaaaat ttcttgcatt tttttagcga 496501 ataatggatc tggacgatct ggtttagcag gatgctgcag catttttgtg tgcttaaaca 496561 tgtacccatc tcctttttcg tttatctctt tttatatttc cgatcgatag aaagataaac 496621 gaaaaacagc gtatcgagat gggaactatg aatcttttcg cagctccaac agttcccgga 496681 tcagctcccg gccaaagatg ggctcatact gccggtaaac agggtcaaga cgcttcatcc 496741 attcttgttt ctctttatct gacagctcat aaatatgtat agcagaattc tttttgattt 496801 cttccagctg ctccttgttc atttgttcgg catacgtttc attccactcc gttgtctcct 496861 tcatcgcttc agtcaaaatg cgtcttgttt ctggtgtttg cgccttccag aagtgttcat 496921 cagtcatgac agcgtagccg agataaccgt ggctgcttat tgtcaaatag tcctgaacat 496981 tataaaattt tttagaatag atgtttgaaa ttgtattttc ttcgccatcg actacattgt 497041 tttctaacag ctgaaaggta gaattgaagg attcctgatg aggtgttgcg ccaagcagct 497101 tgaactgatc ctcaatcaca tcgctttgca taatgcgcag atcctgccct tttaagtcat 497161 ccggtgtttt gaccggccct tgatttgttg tgatttgctt aaagccgttc gtccaatagg 497221 ccaatccttt caattggttt ttctttagag aatcaaacag ctgtgtgccg atgcttccgt 497281 tcagcccttt tttgacggcg ttgtaatctg taaatgcata cggcagatcc agcactcccc 497341 attcaggcga gagcatgccg agcttcgatg tggagggggc gataaattga acatcgccgt 497401 tttgcaatgc ttcaatttct tcaatgtccg agtacaggct tccattcgga aatacttcta 497461 tttttatttt tccgcctgat ttttcgttca ccagatcagc gaatttattg gcggccagcc 497521 cttttggcgt attttcagca accacgtggc tgaatttaaa cacgatttga tcctgcaggc 497581 cttcctggtc gtcatcataa acaatctttt tattgccggt atgatcatgg aatccgataa 497641 ataaagcggt tgcaattcca gcgatcatca gtgcgagaca tgcaagcaaa ctcttcatga 497701 aaagccctcc cctatgttaa ggataatggg ggctatgaca ttcgtaaaga cctgaaagga 497761 gaagctgatg aacaaaaaga agctctcaat ccgttggaaa atcacgatct tatcctatat 497821 actcgtcatt ttctcctttt tgatcggcgg cattgtgctc atcggcaaca ttcagcatac 497881 agaggagcgg gagctgaaaa agcggctgat gaatacggcc cggacggtgt cagagatgac 497941 agaagtgaaa gaagccttgg cgcgaaaaaa acaaacagaa gcggttcgcc atgcggttga 498001 agaaatcagg atgattaatg aagcagacta tattgtcgtc atggatatga atcacatccg 498061 atatacgcat cctgtcagca caagcattgg caagaaatca gaaggtgcag acgaggaggc 498121 agcttttgcg gagcacattt atttctctga agcaaagggc gagatcggca cggcggttcg 498181 cgctttttat ccggtaaagg atcaagacct gaaccaaata ggcgtggtgc ttgtcggaaa 498241 aacgctgccg gggatcgctg acatcctgct tcatttaaag cgtgatatcg ccttcatcgt 498301 tgtgctgaca ctcggctttg gccttgctgg ttcctttttg ctggcccgcc atatcaaaaa 498361 acaaatgttt cagcttgaac cccatgagat tgtccgaatg tatgaagaac ggacagcgac 498421 gtttcactcg atgaatgaag gggtgatcgc tattgacaat cgtctcgtca ttacgatctt 498481 caatgaaaaa gcgaaacaga tctttgaagt gcagggggat ctaatcggca aggtgatttg 498541 ggaggttctc aaggattcgc gcctgcccga aatcgtggag cggaacaaag cggtttataa 498601 tgaagaaatt cgtgtcagcg gtaaggtgat catgagcagc agaattccga tcgtcatgaa 498661 gaaaaaagtg atcggcgccg ttgcgatttt tcaggacaga acggaagcgg ccaagatggc 498721 agaggaattg actggtgtca gaaactttgt ggaggcgctc cgtgtccaaa accatgagca 498781 tatgaataag ctgcacacga tcgccggtct catccagctg gggaaatctg aaaaagcctt 498841 gcagcttgca ttccaggcgt caactgagca ggaaaatgtg actgaatttc tgcaccgctc 498901 gattcaaaat gacgctgcgg caggccttct attaagtaaa atcagaaggg gaagagagct 498961 cggcattgct gttcatatag atgaaaacag cagtcttcag caatttcccg agcatgttga 499021 tcagcatgat attgtcgtgc ttttggggaa tctgattgaa aatgccttcg gctcatttga 499081 aaccgttcaa tctgaagaca aacgaattga cattagtatc gaacaaacag atgatatcct 499141 tgctatttta atagaagata acggctgcgg aattgaaccg acacatatgc ctcgccttta 499201 tgacaaaggt tttacggtca ataaaactgg cggcacaggc tatggcctgt atctagtgaa 499261 acaaatcata gacaaaggat cgggcacgat agaagttgat tcacatgcgg ggcaggggac 499321 atctttttct atcgtttttc caatgaaggg ggaggaagca cagcatggct cgtaaagaat 499381 ggaaggttct gctcattgaa gacgatccga tggttcaaga ggtcaataag gatttcatta 499441 caactgttaa aggcgttact gtctgtgcaa cggcaggaaa cggagaggaa ggcatgaagc 499501 tgattaaaga agaacagcca gatctcgtca ttctcgatgt gtacatgccg aaaaaagacg 499561 gcatcaagac cttgcaggag atcagaaagc aaaagcttga agtggatgtc attgtcgtct 499621 ccgctgcaaa agacaaggaa acgatctcac tcatgctgca aaacggggcg gttgactata 499681 tcttaaagcc gtttaagctt gagcgaatga gacaggcact cgaaaagtac aagcaatata 499741 aacaaaaaat cgaagcgaat gatacgctgt cccaggaaca gctcgatgcg atcctgaata 499801 ttccgcagca ggccgtacag gatctgccga aagggttgaa tcacttcacg atgaatgaag 499861 tcactgcttt tttgaaacag caaaccgcat ccctttctgc tgaagaggtt gccaaggcgc 499921 tcggcatcgc cagagtgaca gccagacgat atcttgatta cttagaaaaa accgggatca 499981 tcaaattgga cgttcaatac ggcggagtcg gccggccggt caaccgctac gtgttaaaag 500041 gataaacctg agaccaaaaa gaccaaaatg tccgttatga tcataaactt ccccagactg 500101 tatgaaaacg ctatcattct agtaagaaag acacaaaagg cgaataggac agggggatga 500161 aggatatgaa actgtttaaa aatttaacag ttcaggtcat aaccgcggtc atcatcgggg 500221 tcattgtcgg gctggtctgg ccggatgtcg gcaaagaaat gaaaccgctt ggtgatacat 500281 ttatcaacgc tgttaaaatg gtgatcgcac caatcatttt cttcacaatc gttctcggga 500341 ttgcaaaaat gggcgatatg aagaaggttg gaaaagtagg gggaaaagcg tttatctatt 500401 tcgaggttgt caccaccctc gcactcatta tcggtttatt tgtcgtcaat attatgaagc 500461 cgggtgcggg tcttgattac agcaagcttg aaaaaggaga tgtatcacaa tacacgcaaa 500521 atggcggtca gggaatcgac tggattgaat ttattacaca cattgttccg tccaacatgg 500581 ttgatgcctt cgcaaaaggg gacattttgc aggtcttatt cttttctatt cttttcggag 500641 tgggtcttgc ggcattaggc gaaaaaggaa aaagcgtcat tgatttcttc gacaaggttt 500701 ctcacgtttt tttcaaaatt atcggctaca ttatgcgtgc cgcgccaatc ggggcattcg 500761 gggcgatggc gtatacaatc ggacacttcg ggctcgattc catcaaaccg ctggcaagct 500821 taatgatgtc tgtttatatt acgatgttcc tgttcgtatt tgttgcttta aatatcatct 500881 gcaagcttta cggattcagc ctgtggaatt accttcgctt cattaaggat gagcttttga 500941 tcgtgcttgg cacaagctct tccgaatcgg tgcttccgcg tatgatggat aaaatggagc 501001 gctacggctg ttccaaatcc gttgtcgggc ttgttattcc gacgggctat tcgtttaacc 501061 tcgacggcac atccatctat ttatcaatgg cgactgtctt tttggcacag gtgtttggag 501121 tagacctcag catcggccag caaattacga ttatcctcgt tctgatgctg acatcgaagg 501181 gagcggcagg tgtgacggga agcggattta tcgtccttgc ctcaacgctg tcagcgctgc 501241 aggtcattcc gctggagggg cttgcactcc tgctcggggt cgaccgtttc atgagtgaag 501301 gaagagccat tgtgaacctg atcggaaacg gaatcgccac gatcattgtt gccaaaagcg 501361 aaaatgaatt tgatgaagca aaaagcatag aggctgttga aggcatgaaa aaaatgaaaa 501421 cagcagtctg aaaaaagaac ggcccatcca tgggccgttt ttttaattgt ttaagaatta 501481 ttaaggtaag gacagagacc tcagcatttt tttgttatat aatttacaaa tggatactat 501541 attgaatgaa ggacgtttgt cctaacagga gtgtataaat ggccgcttta gttaaatttt 501601 ttcagcaccc gggagtaagg cgtttctcca tctttgtcgt gttaactggt gtgttatatc 501661 tatttaagag catgatcaac ttaatattgc ttaccttcat tttcacattt ctaatggatc 501721 gtttggagct tgtcgtgcgg cagtttgtaa gccagttctt ccgcgtgagc cagcgggttg 501781 tcattacgtt tctttacatg ttgctggctg tgctgcttac agtcgggggc tttgtgtttt 501841 atccggtcgt cgcggcgcag atccagcagc tggtaaagca gattaaacat attgcgtatc 501901 atcctgacag catccctttc tttgatgaga tcaccagtgt cttcggagat attaacatca 501961 gttcatatgt caaagagggc ttcaatgtag tgtatacgta tctggccgat atcagcacat 502021 tcggcttgca ggtcgtgatg gcgctcattc ttagcatgtt tttcttattt gagaaaaaac 502081 ggctttctga attcatggcg aaatttaaaa cgagcaaact tagggtcttt tatgaggaga 502141 ttgctttttt cggaagcaaa tttgcaagaa cgttcggcaa ggtgctcgag gctcaattta 502201 tcattgcgct cgtcaactgt attctgacgt ttatcgcgct ttggattatg cattttccgc 502261 agctgtttgg gctttcgatt atggtgttct tccttggatt gatccctgta gcaggcgtcg 502321 tcatttccct gattccgctc agcattatcg cctacagcac tggcggtgga atgtatgtgc 502381 tctacattgt ccttgtcata ttcgccattc atgcgatcga aacctatttc ttaaatccga 502441 agctgatgtc ggcgaaaaca gagctgccaa tctttttcac cttcacagta ctcattttct 502501 ctgaacactt cttcggcatt tggggtttaa ttatcgggat tccgatcttt gtgtttctcc 502561 ttgatattct ggatgtcacc aacaaggaag ataggtctaa aggaccccga gagaatagcg 502621 ataaaaagta gtttaaaatc gaataatgag tgtgcctcga tctgccggcc tgcctgttca 502681 gggcatggaa ttaagactcg gaatcggagc ttggcattgc cttgcacagt ggtgaacaca 502741 acaggtgaca atgcttgtca tcagtacgga aactgaaaag aacaaacagt cggagcaaac 502801 gctcatcatc ggtttaacca aacatttgga agcaacaaat gctataatac aaacagtgcc 502861 taatgttggg cactgtttat tttttgtcga aaaaggagga aggctttatg gctgagccga 502921 ttttacatat tgaaggcctc gataaaaaaa ttgggtctaa acagatttta aaacagatca 502981 gcatggacgt catggagggt gaaatcatcg gccttctcgg tccgaatggt tccggaaaaa 503041 caacactcat ccgtatcatc gtcgggctgt tgaaacaaaa cagcggaagc gtgacaatca 503101 gcggattcca gcatgataca gagtttgaaa aagcgatgga agcggttgga gcgattgttg 503161 agaaccctga gttctatccg tacctgacag gctgggaaaa cctcaagcac tttgcgaata 503221 tgcacaaaaa aatagcggat gaacggcttg atgaagtggt ggaacgtgtc gggctgacgt 503281 cagcgattca tgataaggtg aaaacctatt cccttgggat gcgccagcgt ctgggaatcg 503341 cccaggcaat tcttcaccgg ccgaagcttc tcattctaga tgaaccgaca aacggcctcg 503401 atcctgcggg gatgaaggat tttcgggatc atattaagga actcgcagaa atggaaggaa 503461 cagctgtcct gttcgccact catttattgc gcgaggttga agacttgtgc gaccgtgtca 503521 tcatcattca aaaaggtgag atcaaagcgg aagtcagctt acaaggaacc gatcaaacca 503581 cagaaaaagc gattatagaa gtgcagccgc aagaaaaagc gctcaattgg ctgacaggca 503641 atcaatatca agctgagagc caagacggga cgattgtagt tgaggtggca aaagaaaaca 503701 taccggagct gaaccgatca cttgtcggac aagatctgaa tgtattttcc attacgcctt 503761 acacgcagtc actggaagac gaatttataa aagcgacaac agctcatcaa gaggagggag 503821 aagagcttgt ctaaattaat ttggaatgaa catatgaaac tttttaatcg gaaggtcact 503881 ttggtttctc ttatcctgat ggctgtcttt caattcttca tggcattgat cattaaacgg 503941 attgtcatca gtgccggaac agatgaaaac ttcatcggct atttatcgta tacaccgagc 504001 ctgaacattt tgctgcaggc tttaacgatc gtaattgcag caacaattgt ttcgatggaa 504061 tttgataaaa agacgatcaa atttttgctc attcgtccgg ttaaacgcca aaaggtcttt 504121 tggtcaaaat taatcacagt cgtgatggtc agcttctatt tgtatttggc atactacatt 504181 ctggcattat tattcggtct cttgtttttt ggcacatcgg tgactgcgga atcaaagaca 504241 ttgctggtca acaccttggc gctgatcggg tcaaactggc ttgaagctgt aatgatggga 504301 ttattcgggc tgctttgttc ttcgctgttc cgcaatagcg cggtagcagt tgttgtttct 504361 tttgtcgttt tatacggagc gagtacactt gttcagctca tgaagttgtt tgaaaacaag 504421 tggggcagct ttttgctttt tgcgaacact gactttacgc aatacagaag cggagagaca 504481 gcgttgtttt caggcatgac gccattgttt tcaattggaa ttctcatcat acatgccata 504541 ttcttcatcg ttgttggctg gtggtgcttc tgtaaacggg atgttcgggt ctaaaggcaa 504601 ggaatgacat ttttgtgaaa aagctcacgt aaatcaatat catttgatat tttggtttat 504661 actaaaggta ctgacggagg tgtctcgatt gaggaacttt attaccgctt taccgatcgt 504721 attgctgctt ggattctcat ttgtgtcatt catgtttcag tttgaacatc ttgtttattt 504781 caggctcgcg cttgggttgt tttctctcgt gggactgtac atgatatata aaatgaagac 504841 gggcatccgc tattttatca tctatctgta tgccagctgg attgtgttgg ccgcagtgac 504901 cgcttttgaa gagccgattt tctcaagctt tttctttggc ggcctggtga tgacgatggg 504961 ttacctgaca tatatgctga tttatctcgg catgaaacaa gaccgggatg caaatcctgt 505021 gtaatcgcgc tgttcccttg gggaacggcg tgtttttcta tactgggcaa aaggttaaca 505081 gttgcggaaa aatggcagga aatctataat acatattaaa tttatcggaa ttaaaactgg 505141 ggggctgccg gatgtcatta tttatacaaa acgatcaaca gcggcaatgg atggagaaaa 505201 tcggacggat tgcggatgaa tttcagcaaa cagctgctga agatgacgaa cagggacgtt 505261 ttcctgcaga gaaaatacaa aaactgcgtg atgctgggta tacagcatta acattgccgg 505321 catctcatgg cggagggggc atttctgttt acgatatgct cttgtttcaa gaacggcttg 505381 cacggggaga tgctccgacg gctcttagca tcggctggca tttgagcgtg atcggggagc 505441 ttggagaagg caacagctgg gatgaagacg tatttgcatt tgttgccaag gaagtccaaa 505501 acggagccgt cattaacagg gcggcgactg aagcgaaaac cggaagcccg acaagaggag 505561 ggcgtcccgg tacacacgcc gtcaaaaagg atggcaaatg ggcagtgaac gggagaaaaa 505621 cctttacgac gatgtcacaa gctctggatt attttttagt aaccgcatgg attgaggaca 505681 aacaaacaac aggcgtgttt ctcattcata aagatgatcc cggcttgtcg attgaagaaa 505741 cgtgggatat gatggcgatg cgggcgactg ggagccatga ccttgtactg aacgaagtaa 505801 tgcttgatga gaataagctg gtggaactgc ttcaagggcc tcgtggagct aagccgaatg 505861 gctggctgct tcacattcct gcgatttatc ttggtgtggc tcaagctgct cgtgactatg 505921 cagtgcaatt tgcatctgag tattctccaa acagcttgaa tggaccgatc aagaatgtcc 505981 cggccgtaca gcaaagaaca ggcgaaatgg agcttgaact gctcaatgcc agacactttc 506041 ttttccatat cgctcaattg tatgacgatc cggtgcggcg tccacacttg accagcgagc 506101 tcggtgcggc gaaacatatc gtcacaaacg ctgcgctgtc tgttgttgat aaagcgatga 506161 gaattgtcgg ggccaaaagc ctggaacgaa ccaacccgct tcagcgctat taccgtgatg 506221 tgcgcgccgg tcttcacaac ccgccgatgg atgacgccgt gatacacaag ctggcagctg 506281 aagcgtttga gtcataaaaa aaagagcctt accggctctt tttatgtatt gttttgctct 506341 tgcagatttt tttgatgctt gcggtcgatc ctgtcataaa taacgttcat cagctttgga 506401 ttgcccataa tcgcctcttt gttttcctgg atcagctgtt ggtaagtttt cactttacgc 506461 ttcggcatgc tccggcgccc tcctgacatg tttgtattca ctttctaact ccgtcagcga 506521 caattcatac agatgacgct ttgacttttt gtatatacca ttctgtatta acagatgaat 506581 gagctgtttt tttctgattt ctgcagactg aggtgtcatt gtgtcaccaa cctccaatca 506641 aacgatattg ataatcatta tcaattaact tcagtataca atgtccgcaa tagcctgtaa 506701 agatgaaaag agtcctattc ttggccaatt tacaaacatt caacaaatcg acaaaaagtt 506761 tcccgggcaa taatttgctg tcgaaatatt ccgcttcatt gaacgcaccc tgctattttt 506821 catgttttga accatactat gtaatagaat ggaggctggt attcaatgga gcggacagaa 506881 aatctgaaaa agggagaaaa aggggcgctc ctcaatattt ttgcatatgt catccttgct 506941 gttgtaaagc tagttatcgg gattctatat cattctgaag cgctgagagc agacgggtta 507001 aataatggaa cagatattgt tgcgtcagta gcagtgctga taggattgcg gatttctcaa 507061 agaccggctg acagcgatca tccatacggc cattatcggg ctgaaacaat ttcgtctctt 507121 gttgcgtctt ttattatgat ggcagtcggc attgaagtgt taatcggcgg aggaaaagcg 507181 attgcgggcg gcacaacgga aacgccaaat cttatcgcgg catggacggc gttaggcagt 507241 gctgtgttta tgtatggcat ctatttatat aacaaaaggc tggcagcgtc cattaaaagc 507301 tctgccctga tggcagcggc aaaggacagc aggtcagacg cttttgtaag tgccggcgcg 507361 tttatcggtg ttttttcgtc ccagctgaag ctgccgtggg ttgatccggt aacggctttt 507421 atcatcggca tcatcatttg caaaactgcg tgggatatct ttaaagacgc ttcacattcc 507481 ttaacagacg gcttccattt aaaagatctt gagccttaca aacagaccgt cggcaggatc 507541 gaaaatgtgc atcgcctaaa ggatgtgaaa gcgaggtatt taggcagtac agttcatatc 507601 gagatggtga ttacggttga tccgaagctt acagtagaag aaggccatgg agtggcggat 507661 gaagtagaag acaaaataaa acatgaacac gatgtcactc atgttcatgt tcatgtagag 507721 cctgacgaca taaaataagg ctgtttaacg aattagctta tatgttcaga taaaaattca 507781 gtcacttctt caggcgtttt ggcattggcg ctgtgaaggt gagctgtttt ttcaccgttc 507841 ttgaaaataa gcaggctggg aatgcccatt acttggtatt tttcagccag gtcaggaagc 507901 tcgtccttat tcagctcata ccagtcgttt tggttgtatt cttccaaaat atcgccgatg 507961 aacatattca tgcgtgtgca gtctgggcac caatcagcat aaaactttac aatgatttct 508021 ttatcagatt gaatcagttc attaaattgt tcgtttgttg tgattttttt catatgtcac 508081 atctcctttt caatgccatt ttaatataaa ataaaaagga attacataca aatgcattca 508141 acatcagcat gcccaaaaat aattagatca ttttccggtg aaaatgataa gatagtaaag 508201 atgaattgta gtggggggag tatccattga aaacaagtct aggattagtg tacggaggaa 508261 agtcggcaga acataatgtt tccctgcaga cagctctggc tgtaatcaaa gcgctaaata 508321 ctgagaagtt tgatatacat ccgatttata taacagaaaa aggcgaatgg gttagaggcg 508381 cccgtttaac tgaacctgtt tcaaacgtga aaatgcttca atttgagcaa ggaggcagtg 508441 ctttttctcc agctgccctg aaccaggaga tgtttccgca ggaagcgtca cagcaaaatg 508501 aagccatcga cgtcgtattc ccgctcctcc acggaccgaa cggagaagac ggtacgatcc 508561 agggaatgct cgagctgttg aacattcctt atgtcggcaa cggagtgctt gcttcctcag 508621 ctggcatgga taaagttgtc atgaaacatt tatttgcgca ggttggcctt gctcaggcta 508681 aatacgcagc tttccttaag aaagactgga ctcgttctcc gaaagaaagc tgtgaggagg 508741 ttgaacagga attaggctac ccttgcttcg taaaaccggc gaacctcggc tcaagtgtcg 508801 gaatcagcaa atgccgaaac cgtgaagaac tgcaaaaagc gtttgagctt gctttccaat 508861 atgaccgcaa agtcgtcgtt gaagaaggaa ttaacggccg cgagatcgaa atcggcgttc 508921 ttggaaatga tgatcctaaa tgctctgttg tgggagaaat cgcaccgaag acagatttct 508981 acgattacaa agcgaaatat gaggatggag atactgatct gatgattccg gcgattgtga 509041 ctgatgagga atacgcaaca atcagtgata tggcgatcaa agcgtttaaa gcgatcgacg 509101 gttcaggact cgtcagagcg gactttttcc tgacagctga cggcgaagtt ctgatcaatg 509161 aagtcaacac aatgcctggc tttacacctt tcagcatgtt cccgttgctc tggaaagaag 509221 ccggagtgga atatgctgac ctgattgaac agcttgtgga gcttgcaaaa gaacgccacg 509281 ctgaaaaaca attgattaag catacattct aatgaagaag gacactgccg gtaaaagggc 509341 agtgtttttt cccgtatata caaaagaaag agagggacct tacttgatta agcgaacagt 509401 aaaaaacatt gccgaaatgg ttaaaggcac actagcaaat ccgcaatatg aacaaacagt 509461 cattcatgga gtggcaaccg atacaagaaa actggaacaa catcagctct ttattccgct 509521 gaaaggggaa cgttttgacg gccactcttt tgtggagcag gcctttgaag ctggtgtagc 509581 ggctgttctt tgggatcggt cagtaccaaa tccgcccgag aatcacgccg tcattttagt 509641 ggacgatacc cttactgcac ttcagcagct tgcaaaagct tatttgcagg agcttggcac 509701 gcgtgtcatc ggagtaaccg gaagcaatgg caaaacgaca acaaaagata tgattcacgc 509761 cgtattgggg acccagtacc gtgtccacaa aactggagga aacttcaata atcatatcgg 509821 tttgccgctg acggttttag cgatgcctga aaatacggag atcgccgtat tggagatggg 509881 aatgagcgcc aaaggagaaa ttgacctctt gagccgactg gcaaacccgg atgcggcagt 509941 gattacgaat atcggcgaat cgcatatgca agacctcggc tctagagagg gcatcgcgga 510001 ggcgaagctt gaaatcataa acgggcttaa agaagacgga gtgctgattt atatcgggga 510061 cgaaccgctt cttcaaaatg catacagctg ccagacgaaa acgtacggta cgggaacgca 510121 taatgattat cagcttcagg atgtcagcca gagtgaggaa ggaacccatt ttacaatcaa 510181 agggatagaa aacacgtttt ttattccaat actcggcaag cacaatgtga tgaacgccat 510241 ggctgcaatt gctgcagggg cttattttgg catcgcgcct gaggatgcgg caaaaggact 510301 gagcggccta aaggtaaccg ggatgaggct tgaactcatc aaaacagaca gcggcctttc 510361 gataatcaat gacgcttata atgcgagccc gacttccatg aaagctgcaa ttcaattgac 510421 agaaagcctt gaaggctacg gcaaaaaaat gctcgtgctc ggtgatatgc ttgaactcgg 510481 cgatcttgaa gaaacgttcc ataaagagtg cggcgctgtg atcagccctg ataaaattga 510541 ccgcgtcttt acgtacggaa aactgggagc ttttatcgcg gaaggcgccc tgaaacactt 510601 tgagaaagac cgcgtcagcc attacactga gaaaaaagat ctccttcaag ctgtgaagga 510661 aaacgcatca aaaggcgatt tgattttatt caaagcgtcc agaggtatga agcttgaaga 510721 aatcgttaaa gatttaatag agagcccgct ttcataagaa aatattttgc gaaaaaacgc 510781 atattgcatc ataaaataac ctgatatgca aacactaatg tatgccggcc gaaaattatg 510841 tatatctggc cggctgcggc tatgatacaa tatatatagg ttatttcgcg atacgaacat 510901 attcgtccgg acttttcatc gtgacccgaa gttctccgct ggattcttgg gagcggatgg 510961 agcagcagcc ggcatattcg agatgccgat ctgcttctca tcttattgaa aaacaaatag 511021 tgtaatggta agataaaact taaagtaatt cgggctttgt atacggatgg atcctgtcct 511081 tcttgtctaa agggcagttt tataagtggt aaatcacgac attactgaaa cagcaattag 511141 aaggagtttg aataatttga ctataacgtt tcaagatttt aatttaagtt ctgatctcat 511201 gaaagcaatt aatcgtatgg gatttgaaga agcaacaccg attcaggcac aaacgatacc 511261 gctcggactt tcaaataaag acgtcattgg acaagcgcaa acaggtacag gtaaaacagc 511321 tgcgtttggt ataccccttg ttgaaaaaat taaccccgag tctcctaata ttcaagcaat 511381 cgtaatcgcg ccaacccgtg aattagccat tcaagtatct gaagaattgt ataaaatcgg 511441 acaagataaa cgtgcgaagg ttcttcctat ttacggcgga caggatattg gacggcaaat 511501 ccgggcgtta aagaagaatc cgaatattat tgtcggaaca cctggacgtc ttcttgacca 511561 catcaaccgc cgcaccattc gtttaaacaa tgtaaatacc gttgtaatgg atgaagcgga 511621 tgaaatgctg aacatgggat tcattgacga tattgaatct atcctttcaa acgtgccaag 511681 cgagcatcag acacttctgt tctctgccac aatgcctgcg ccgatcaaac gcattgcaga 511741 gcgcttcatg actgagccgg aacacgtaaa agtaaaagcg aaagaaatga cggtttctaa 511801 cattcagcag ttctatttgg aagtgcaaga acgtaaaaaa ttcgatacac tgactcgcct 511861 tcttgatatt cagtctcctg agcttgcgat cgtattcgga cgtacaaaac gccgtgtcga 511921 tgagctggct gaagctctga accttcgcgg atatgcagct gaaggtattc acggtgactt 511981 aacgcaggcg aaacgtatgg ttgcgcttcg taaatttaaa gaaggcgcaa tcgaagttct 512041 agtcgcaact gatgttgccg ctcgcggact tgatatctca ggtgttacac acgtatacaa 512101 cttcgacgtg cctcaagatc ctgaaagcta cgttcaccgt atcggaagaa cgggccgtgc 512161 aggaaaaaca ggtatggcga tgacgttcat tacaccgcgt gagaaaagca tgcttcgcgc 512221 aattgaacaa acaacaaaac gcaaaatgga ccgcatgaag gagcctacac ttgatgaagc 512281 gttagaaggt cagcaacagg ttactgttga acgtcttcgc acaacaatca gtgaaaacaa 512341 cctgaacttc tacatgacag cggcagctga gctgcttgaa gatcatgatg cagtaacagt 512401 ggttgcggcg gctatcaaaa tggctacaaa agagccagac gacacaccgg ttcgcttaac 512461 agacgaagcg ccgatggtca gcaaacgcta caagaaccag cgctcttcta aacgcagaga 512521 cggtcaaggc ggcggctacc gcggcggaaa agggaaaagc aacaaccgtt cttcctatga 512581 caaaaagcgt tcaaacgatc gccgttcttc aggtgacaga cgccagaaaa aatcttacta 512641 atttgatcga ttcagagccc aaaacatgat gttttgggct tttttatgtt cgtgatttgt 512701 tattcagcaa actttcagct gacggaagcc atttttctct gtatgcttaa gaatgaaacc 512761 tttctgtaaa agagacgtat aaataacgac gaaaaaaagg gaggtaggta tttttgagag 512821 agcagccaaa aaaccaaatc agtccagacg gattaaaggt ttggcgactt caagagatca 512881 tcatatccgc tgtttgcttg cttattgtca ttgcagttgc agtgttaagc tattattttc 512941 attggccgta ctggatcagc ggcgtgctcg gcgctgtttg gctgctggga tcgattgtga 513001 cggtctttat cattccgaag gtccgtcata aggtgtggcg atatgaagtc catgaacatg 513061 aaatagatat tcagtcaggt atttttgtgg tgacacgtgt gattgttccg atggtcagag 513121 ttcagcacgt cgatacgtca caagggccat tattaaaaaa atacaacctg gcaacggtga 513181 aaatttccac agccgcgacc gttcattcga tccccgcttt agagatggag gaagcggatc 513241 ggctaagaga ctccatttcc cgtctggcga gggtgactga cgatgatgtc tgaaccgaaa 513301 cgcctgcacc cggtggcagt cattttgaat ttatgccata ccattattca aacgataaaa 513361 aatatcattc tgccattctt ttttgtgtat attgtcaatt caaaccatac tgtccgtttt 513421 tacggagcca ttgcgctcgg tgtgctgttc atctggcttg tagcggcaag cattatcaaa 513481 tggagaaggt ttacctatcg aattgaagat gatgaattta gaattgaaga aggcttattt 513541 gttacgaaaa aacgatacat atcgattgat cggattcaaa caatgaatac gagcgcgggc 513601 cttgtccagc aaatctttaa gcttgtgaag ctgcaaattg aaacagcagg cggaggcaag 513661 gaggcagaag ccgttctttc tgctatttct gttgaagaag cggaacgcat caaagaagct 513721 gtctttaaga aaaaagcgca aagacgagaa aatgaacttg atgaagaacg gcttgaagct 513781 gaagaggagt tggatccgtc cgttgaggtg caagagcact atcgcatgaa cgcgaaagaa 513841 ttgctcatgg ccgcttctac ctccggcgga atcggagtca ttatctccgc tgtatttgca 513901 cttatttccc agcttgatga agtgctgccg atggattggt tattcgataa attttccttc 513961 cttcagcacg ccagcatcgg tatttatgcg gtactcattt ttatcggttt atttatcgcc 514021 tggattttca gcatcgcggg catgatgttt agatacgcga actttcaaat cataaaaaaa 514081 gagcaggaac tggtgatttc aaggggaatt attgaaaaac atcaagtcac gattccgctg 514141 cgaaaaatac aagccattaa aatcaaagaa aatatcattc gccagctttt cggctttgta 514201 acggtgtcca tcgtcagcgc aggaggcggc gaccgggaaa aagaagaagg cgctttgacc 514261 attctctttc caatgattca taaaaaaaag cttccgcaca tgctccgaac atttacgccg 514321 gaatacacgc tggaagaaaa ctgccgccgc ctgccgcggc gcgcgttgaa acgctatttg 514381 ttccgttctg tcattttttc actctttttg atcatcccgt tatgtatctt ctttcagcca 514441 tggggctatc tgtcagtgat cctgctgccg atagaattgc tcttcggcta tctcgcgtat 514501 aaagaggctg catggacgat caacggggac cgtcttcagc tgacgtctag atttataggc 514561 agaacaaccg ccattgtact gaaaaaacga atgcaggtct gcaagttcag ccaatcctat 514621 ttccaaaaga aaggccgctt gtataccatt tctacttcgg tgaaatcatc gagccatatg 514681 gaagagttaa cggtgaggga cgtaggtgaa gaggatgcag ccttcatttt aaagtggtac 514741 tcatatgaaa aagcggacgg ttaataccgc cgctccagcg tgtcggcaaa ccctcgcatt 514801 cgttgtcagg actgcgcttc ggtgctcaat gcgaagtgga tcaacggcta aattctcagg 514861 cgtcctgcct aaacgccgtc gtcatcacat cctgtgaaag tccgctccta tgctcgtcct 514921 tcctagactt catgggtttt caatcacgct gaaaagatga caaaatccta aaatgaaaac 514981 cattttagga ttttgtcaac aatctgaagc ggcggttaat accgccgctc ttttttttgc 515041 acgcataaaa acgaaagaag aaacccgccg catagtccaa acaaatgggc catcatgtta 515101 atattggagt tgataaacga catgagaacg gcaaatgcga gcagtgtgat gatcattttg 515161 gaatgctcct gcccaattaa ctcattgcga aaaagaacca taaacaggta tacgccaaat 515221 agcccgaaaa tggcgcctga agccccgaca tgcacgtaat caagcggctc tgtaacataa 515281 gtgccgatat tgccgatgat gccggagccg gcgtatacaa gaaggaaacg cgcttttccc 515341 agcatgcgtt ccaaagccgg ggcaaataaa aagatggaca tggaattaaa cagcagatgt 515401 gtgaaaccgg cgtgcagcaa aatcggtgtg ataagccgcc accattcacc gtttgcgaca 515461 cctagattat agcctgtgac ggtatccctc cataacacga ctgaatgggc aggaagtgaa 515521 aaaaacagcc agagaacagc ttgcaaagcc aatataaagg tgacaacggg gtaaagcctg 515581 ataaatgttt gaaaattttc agtccgtata aacattccga gccccttttc ttcattttgg 515641 tatatctata gtaacacgtt tatgagacaa accatttaaa tagtacgtac gcaaaggagg 515701 ttatcataca tgatttacgg cattgggctg gacattaccg agcttaaacg gatcgcctct 515761 atggctgggc gccagaaaag gtttgccgag cggattttga cgcgaagcga gcttgaccaa 515821 tactatgagc tttcagagaa aagaaaaaac gaatttctcg cgggcagatt cgcggcaaaa 515881 gaagcgttct cgaaagcatt tggcaccggc attgggaggc agctcagctt tcaggacatt 515941 gaaattagga aagaccaaaa tggcaagccc tatatcattt gtacgaaact gagccaggcc 516001 gccgttcacg tatcgatcac tcatacaaaa gaatacgctg ccgcgcaggt tgtgattgaa 516061 aggttgtcaa gctagtctgc atattaggga aaccccactc atatatttga tagtgcatta 516121 agggagacaa gttgtttgag gcttttatgg tacgcatctg ttctgcctaa acgtgtaccg 516181 agcgtaccgt taaagtcaaa caagcgattt cttcctttta catcaattga gaaaaagggg 516241 ttgaaaaagg tgagaaaaag ctttgttttg cttttaacgg gactgcttgc tgttcttatt 516301 ctttctgcct gcgggcaaaa aacacagcaa gatattgtgg ccgggttaga tgaaaaggcg 516361 aaagaataca cctcgtacaa agcaaaagcg aaaatgacca tcgagacagg gagtgagcct 516421 caagtataca atgtggaaat ctggcacaaa aagccgtctc tgtacagggt ttatttagaa 516481 aatccgaaaa aggaccaaaa ccaagtcatt ttacgaaatg aaaacggagt attcgttctc 516541 acgccgtctt taaataagag cttcagattt caaagcgatt ggccgaacaa cagcagccag 516601 gtttatctgt ttgaatcgct cgtaaaggat gttcaaaacg attcggatgc agttttcaca 516661 gcgaaagaaa agaaatacgt atttgaaaca aaaacaaact atcagcataa caaaatgctg 516721 cccacgcaag aaatcacatt taacaaaaaa gatatgagcc cgtcatctgt caaagtgatg 516781 gatactgacc ggaaagtgat ggtcaaagta gaattcagca gctttgaatt taataaacaa 516841 tttgataaag aatcatttga tgaaaagaaa aatatgaccc tttctcaaat ggatgtcgcc 516901 acaagcgcaa agccttccga tacatttgcg gtcaaaacgc cgctggaact gccgcttggc 516961 gtcaagctgc ttgaagaaaa agatatatct actgaagacg ggaagcgcat catcatgacg 517021 tacggaggag aaaaatcatt tacgttaatt caggaaaaag cccagattgc caaggcttcc 517081 tcctccgtta cgctgaacgg cgaaccggta aatctcggct acaccatcgg cgccctgtcg 517141 gatgcatcat tatcatggac atatgacggc gtagattacc ttctctcttc taaagatctt 517201 tctaaagagg aaatggtgac agtagcgaaa agcatgcagg gacaatcatc gaaataaccg 517261 ccaaaggcca aacatgattt ggcctttttt tcgttagaca tcgtttccct ttagccttta 517321 attttagtat gatatgtaaa tgatattgaa taaaagctag gaagtgtcgt aatgagcaca 517381 aaaccttttt acagagatac gtgggcggaa attgacttgt ccgcgataaa ggaaaatgtc 517441 agcaatatga aaaaacatat cggtgaacat gtccacttga tggcagttgt gaaagcaaac 517501 gcctacgggc atggtgatgc agaaacagca aaggctgctc ttgacgcagg tgcttcatgc 517561 ttggccgtgg ccattttgga tgaagcgatt tcactgcgca aaaagggatt gaaggcgcct 517621 atattggtgc ttggcgcggt tcccccggag tatgtggcaa tcgctgctga gtatgacgtg 517681 accttaacag gttattctgt tgaatggctt caggaggcag cccgccacac gaaaaaaggt 517741 tctcttcatt ttcatctgaa ggtcgatacg gggatgaaca gacttggtgt aaaaacagag 517801 gaagaagttc agaacgtgat ggcaattctt gaccgcaacc ctcgtttaaa gtgcaaaggg 517861 gtatttaccc attttgcgac agcggatgaa aaagaaagag gctatttctt aatgcagttt 517921 gagcgcttta aagagctgat tgctccgctg ccgttaaaga atctaatggt ccactgcgcg 517981 aacagcgccg ctggactccg gctgaaaaaa ggctttttta atgcagtcag attcggcatc 518041 ggcatgtatg gccttcgccc gtctgctgac atgtcggacg agataccgtt tcagctgcgt 518101 ccggcattta ccctgcattc gacactgtca catgtcaaac tgatcagaaa aggcgagagc 518161 gtcagctacg gagccgagta cacagcggaa aaagacacat ggatcgggac ggtgcctgta 518221 ggctatgcgg acggctggct ccgaaaattg aaagggaccg acatccttgt gaagggaaaa 518281 cgcctgaaaa ttgccggccg aatttgcatg gaccaattta tggtggagct ggatcaggaa 518341 tatccgccgg gcacaaaagt cacattaata ggccggcagg gggatgaata tatttccatg 518401 gatgagattg caggaaggct cgaaaccatt aactatgagg tggcctgtac aataagttcc 518461 cgtgttcccc gtatgttttt ggaaaatggg agtataatgg aagtaagaaa tcctttattg 518521 caggtaaata taagcaatta acttacctaa atggagaatt cataaaacag ctttgcttga 518581 agagtgaata atggtatcat tatcactgga tggataaaag agtcgtatcc gtaagtttgg 518641 tggaggtgta tgttttttgt ctgaatccag cgcaagaacc gaaatgaaaa tcagcttgcc 518701 cgaaaaccta gtagctgaat tggatggtgt agcgatgcgg gagaaacgaa gcagaaacga 518761 actgatatca caagcagtga gagcgtatgt cagcgaacga acaactcgtc acaaccgtga 518821 tttgatgaga cgcggctata tggaaatggc gaaaatcaac ctgaatattt cttctgaggc 518881 tcactttgcg gagtgcgagg ctgaaacgac agttgagcgc ttagtcagcg gaggataatc 518941 atttgattgt gaaacgcggc gatgtttatt ttgctgattt atctcctgtt gttggctcag 519001 agcaaggcgg ggtgcgcccg gttttagtga tccaaaatga catcggaaat cgcttcagcc 519061 caactgctat tgttgcagcc ataacagcac aaatacagaa agcgaaatta ccaacccacg 519121 tcgaaatcga tgcaaaacgc tacggttttg aaagagattc cgttattttg ctggagcaaa 519181 ttcggacgat tgacaagcaa aggttaacgg ataagattac tcatctggat gatgaaatga 519241 tggataaggt tgatgaagcc ttacaaatca gtttggcact cattgatttt tagacatatt 519301 tgcaggttgc tcaaatagag caactttttt tgttttcaaa aaacataaac gatataatag 519361 tgaaataacg aaaaaatatg ttgtttttta ttgggaggta agcgaatttg atgtcgaacc 519421 agactgtata ccagttcatt gccgaaaatc aaaatgaact gctccaactg tggactgaca 519481 cactaaaaga attaagcgag caagaatcct atcagctgac tgaccaagtg tatgaaaata 519541 tatctaaaga atatatcgac attctgctgc tgtctgttaa ggacgaaaat gctgctgaaa 519601 gccaaatcag cgaactggcg cttcgagcgg tccaaatcgg actgtctatg aagtttttgg 519661 ctactgcact tgccgaattc tggaagcgtc tctacacgaa aatgaatgat aagagattgc 519721 cagatcaaga gagcacggaa ttaatctggc agattgatcg ctttttcagc ccgattaaca 519781 cagaaatttt taatcaatac tcaatctcat gggaaaaaac agtatccctg caaaaaatcg 519841 cgctgcaaga gctgtctgcg ccgcttatcc cggtgtttga aaatatcact gtgatgcctc 519901 ttgtcggaac aattgatacc gaacgcgcga aacgaattat ggaaaacctt cttaatggcg 519961 tcgtcaaaca ccgttcccaa gtcgtgctga ttgacattac aggtgtccct gtcgtcgata 520021 cgatggttgc ccatcatatt attcaggcat cagaagctgt aaggcttgtc ggagcaaaat 520081 gcctgctggc cggaatccgt ccggaaattg ctcaaacaat cgtcaacctg gggattgatt 520141 tatcccaagt tataactaag aataccctgc aaaaaggaat tcaaacagca ttggaaatga 520201 cggatcgaaa aatcgtttca ttgggggaat aacattttga gacatccgaa aatcccgatc 520261 ttgaaactgt ataattgctt attagtgtcc attcagtggg aacttgatga ccagacagca 520321 ttaacttttc aagaagactt attaaataaa atatacgaaa caggtgctaa cggagtcgtc 520381 attgacctga catctgtgga tatgattgat tcatttatcg cgaaagtgct gggggacgtc 520441 attacaatgt ctaagttaat gggggctaaa gtcgtcttga ccggcattca gcccgctgtg 520501 gcagtgacgc tgattgaact tggaatcgcg cttgaggaaa tcgaaactgc gctcgactta 520561 gagcaggggc ttgagacatt gaagcgggaa ttgggggaat agcgaatgaa cgaccaatcc 520621 tgtgtaagaa tcatgacaga atgggatatt gtggccgcca gacagctggg acgaaacgtt 520681 gcgaaagaac tgggtttcgg cacggtagac caggctagaa ttacaacggc tatttcagaa 520741 ttagccagga atatttattt atatgccggc aaagggcaga ttggaattga acaggtcgca 520801 gacagaggaa aaaaaggcct gaaaatcata gcggaagacc aagggccggg aattcctgat 520861 atccgaaaag tcatggaaga cgggttttca acgtctggag gacttggtgc gggacttccc 520921 ggggtcaaaa ggctgatgga tgaattcagc ttaaattccg tagcggggga aggaacagag 520981 atacaagcca tcaaatggct tcggtaggag gtaagaacgt ggattttagg gaggttattg 521041 agcagcggta tcatcagctg cttagtcgat atatagccga attaacagaa acatctttat 521101 atcaagccca aaaattcagc cgaaaaacaa tcgagcacca aattcctccg gaagaaatca 521161 tcagcattca cagaaaagtg ctgaaggagc tgtatccaag tctcccggaa gatgtgtttc 521221 attcgctgga ttttttaata gaagtcatga ttggctatgg aatggcttat caggagcatc 521281 aaacccttag agggatacag caggaaatca aatcagaaat tgaaatcgcg gcaaatgtcc 521341 agcagacgct tctcggaact aaagttcctc aggaggaagc gctggatatc ggcgccatca 521401 gtgttcccgc taaacagatg agcggtgatt actaccactt tgtcaaagac aaggaatcca 521461 tcaatatcgc aatcgcggac gtgatcggaa aaggcattcc agcggcttta tgcatgtcca 521521 tgattaaata cgcaatggac tctttgccgg aaacgggcat acacccttct caagtgctga 521581 aaaatttgaa tcgtgttgtt gaacaaaacg ttgatgccag tatgtttatt acgatgtttt 521641 atgcgaatta caatatggac aagcatcaat ttacatatgc ttcagcggga catgaaccgg 521701 gattctatta ttctcaaaaa gacaacacgt tttacgattt agaggccaaa ggactcgttc 521761 tcggcatctc gcaggactat gactacaaac aattcgatca gcatctggaa aagggcgata 521821 tgattgtttt attttctgac ggcgtcacag aatgcagaac ggaaaacggt ttcttggagc 521881 gtcctgatct gcagaagctc attgaggaac atatgtgttc ctctgcgcag gaaatggtca 521941 aaaacattta tgacagcctc ctcaaattgc aggattttca gcttcacgat gattttacgt 522001 taattgtttt gcggagaaag gtttaacgtc tgtcagacga gggtataaag caactagtga 522061 tttgaaggaa aatttgaggt gatacgaatg aatataaatg ttgatgtgaa gcaaaacgag 522121 aatgatatac aagtaaacat tgcaggagaa attgatgtat actcagcccc ggtgcttaga 522181 gagaagctcg ttcctctggc agaacaagga gctgacttaa gaatttgcct gaaagatgtc 522241 agctacatgg acagtaccgg attgggcgtt tttgtaggga cctttaaaat ggtgaaaaaa 522301 caaggtggtt cgctgaaact tgaaaatctt tctgaacggc tgatccgact gtttgacatt 522361 acaggcttga aggacatcat tgatatttct gcaaagtcag aaggtggagt gcaatgaaga 522421 ataatgctga ttacatcgaa atgaaagtgc cggcccaacc tgaatatgtg ggaattataa 522481 gactgacgct gtcaggggtc gcaagcagaa tgggctatac gtacgatgaa attgaagact 522541 tgaaaatcgc agtcagtgag gcgtgcacaa atgcggttca gcacgcttac aaagaagata 522601 aaaatgggga agtgtcaata cgattcggtg tgtttgaaga ccgtttagag gttattgtgg 522661 cggatgaagg agacagcttt gactttgatc aaaagcagca ggatctaggg ccgtacacac 522721 cttcgcacac agttgatcaa ttatcagaag gagggctcgg tctatattta atggaaacgc 522781 tcatggatga agtcagagtg caaaaccact ccggcgtcac cgtagcgatg acaaagtatt 522841 taaatgggga gcgagttgat catgacacaa ccatcaaaaa ctacgaaact aactaaagat 522901 gaagtcgatc ggctcataag cgattaccaa acaaagcaag atgaacaagc gcaggaaacg 522961 cttgtgcggg tgtatacaaa tctggttgac atgcttgcga aaaaatactc aaaaggcaaa 523021 agcttccacg aggatctccg ccaggtcggc atgatcgggc tgctaggcgc gattaagcga 523081 tacgatcctg ttgtcggcaa atcgtttgaa gcttttgcaa tcccgacaat catcggtgaa 523141 attaaacgtt tcctcagaga taaaacatgg agcgttcatg tgccgagacg aattaaagaa 523201 ctcggtccaa gaatcaaaat ggcggttgat cagctgacca ctgaaacaca aagatcgccg 523261 aaagtcgaag agattgccga attcctcgat gtttctgaag aagaggttct tgaaacgatg 523321 gaaatgggca aaagctatca agccttatcc gttgaccaca gcattgaagc ggattcggac 523381 ggaagcactg tcacgattct tgatatcgtc ggatcacagg aggacggata tgagcgggtc 523441 aaccagcaat tgatgctgca aagcgtgctt catgtccttt cagaccgtga gaaacaaatc 523501 atagacctta cgtatattca aaacaaaagc caaaaagaaa ctggggacat tctcggtata 523561 tctcaaatgc acgtctcgcg cttgcaacgc aaagctgtga agaagctcag agaggccttg 523621 attgaagatc cctcgatgga gttaatgtaa tgatccaggt tgaagaaaac gagcatattc 523681 aaactctagt atatcaactg aataaagaag ggaaatcgat ttgcggtgac agttttttta 523741 tgaaagctga tgataaggag ttaatttgcg cggttgctga cggactggga agtggatcac 523801 ttgctaacga atcctctgca gccatcaaag acttagtgga aaactatgcg agtgaagacg 523861 tagaaagcat tatcgaacgc tgtaatcagg cgatgaaaaa caaaagaggc gctacagcat 523921 ctatcctgaa aatcaatttt gagcaaaggc agtttacgta ctgctctgtc ggaaatgtac 523981 ggtttattct gcattccccg tctggtgaaa gcttttatcc tctgccgatt tcgggctatt 524041 tatcaggcaa gccgcaaaaa tacaaaacgc acaccgccac ctatgaaaag ggttcaaagt 524101 tcattataca tacagatgga ctcaacgtac ctgatatccg ctcccatttg aaaaaaggcc 524161 aatcggtaga agaaatatcg aattcgctga aaatgtatac gacatcgaga aaagatgacc 524221 tgacctatat tctcggacag ctgtcctaaa aaaccagaaa aagaagctgg acatccggct 524281 tctttttttt gcggttgact attaataagt gcgcttatta taattaataa gtgaacttat 524341 cattctggga gcttatggga tgtggaatta tgaatacaca gcgatagctg atgtggatgt 524401 gggaaaacct ggaactgtta tcaggaaaca gaaacaatgg atcaatggga gacgggtatt 524461 gcatcagatt ctttgaaagg acaatttcaa aatggaacgg aaggaacatt gcttctgcaa 524521 ggaaaaacaa ttctcttatg gcttgagcat gtggagaaac atcgggcgtt ttctgtcatg 524581 gtcaacatgc ccgcatagca atgtaataat ggagtttttt cacgtgcttc aaaagcaaaa 524641 agaagatttg tgtatcacat atggaattgt attagaaggc gctgaagcaa aaaagtgggg 524701 agaaatcatt gggactgaac tgtctaaaga catgccgacg gctgtcagca ggcttgtcca 524761 tctttacgga ggagtgataa aatgaacaca aattactgga tcggcgttgt gtcagagcaa 524821 catgtattaa aaggcgctgc cggcggtttt gcacagctgt gccatggaaa aaaagccccg 524881 ctcgccaaaa tgaaagaggg agattggctg atttattatt ctccgagaga cgcatatcca 524941 gacggcaaac tgctgcgaag ctttactgcg atcggcaaag taaaaagcgg aaacatctat 525001 ccgtatcaaa tggctccgaa ttttattcca taccgattag atatagacta ttatccatgc 525061 cataaaatcg gtttttacga cattaaatca aagcttgaat ttgttcagga aaccaagcat 525121 cttggctttt tatttcgcag aggacacttt gaaataagca aaaaagattt tttgacaata 525181 gcacaagcga tgggagttaa cataagtgga atggcactct aaatttagcg gtccgaacac 525241 aagcccgggc tttttattat ggcaggccac gcaaagttgg cagcggaaag taggaaaagc 525301 attggctgag tttgacctga cccacgttca atttgttctg ctgacctcgt gcaagtatat 525361 gattgctcac ggagaaaccg tcacgcaaaa aaaacttgca agcttcagcc agaccaatat 525421 catgatggtt tcggaggttg tgcggacgct tgagaaaaaa ggatttatcg aaagaagcaa 525481 aaatccccag gataaaagag aggtcctcct gtctcttaca gaaataggag gagaaaaagt 525541 aacagcggct ttgccaattg ttgagaagat tgatcaagcc ttctttgcag ctgcgatgaa 525601 aaaagagaat tttctgagcg gcttacagga actattgaaa catgagtaaa gatacgggca 525661 gcgccagctg tcttttttta tgtgtttttt tcggtttttg atacactaga gaaagaacga 525721 caaaattgga ggctttggtt acatggaaac gtcagccctt ttaaaacagc aaattgcgaa 525781 agaaataggt ttatcacaaa aacacgttga aagtgtcatc cgcctgcttg aggacggcaa 525841 tacagtcccg tttattgccc ggtatcgaaa agagcagacg ggttcaatgg atgaggttca 525901 gattcagacg atttctgaac gctggcaata catacaaaac ctgaatcagc gaaaagaaga 525961 agtcatcagg ctgattgcag agcaggataa actgacagat aatctaaaac gtaaaatcga 526021 gcaatcggtg aagcttcagg aagtggaaga cctttaccgc ccttataaac aaaaacgtaa 526081 aacaaaggcg acagtcgcca aaagcaaagg ccttgagccg cttgccgact atatcctgac 526141 acttccccaa gatgatcatc tggcagcaac tgcagaccaa tacatcagcg aagaaaaaga 526201 agtgttcaca cgagaagaag cgattgaagg cgccaagcac attattgcgg aacaaatctc 526261 agacgagccg accttcagaa agtggattcg ccaggaaacc ttcaaaagag gaaccattaa 526321 gtctgcagcc ggaaagtcgg cagacaccga tgagaaaaat gtgtatgaaa tgtattacga 526381 gtatgaagag ccaattgcaa aagttgttcc gcatagggtg ctggcaatga accgcggcga 526441 aaaagaagac attttaaagg tagcgatcga accgcctgcg gatcacatta aggcgtattt 526501 agaaaaacaa atcatcaaaa atcgctcaac atccgtaaga gagattttgc aggagacaat 526561 tgaagacagc tataaaaggc tgatccagcc ggcaatcgag cgtgaaatca ggaaagagct 526621 ctcagaaaaa gctgatgaac aggcgattca tattttctca gagaacttga gaaagcttct 526681 tttgcagccg ccgatgaaag gcaaaaccgt tctcggtgtt gacccagcct ttcgaactgg 526741 ctgtaagctc gctgtgtcag atgagaccgg aaaagtcttg aaaattgatg tgatctatcc 526801 gcatgcgcca gtcaacaaaa caaaagaagc ccatgaaaaa gtgaaaaaga ttcttgagca 526861 gtatcaagtc gagatggtgg cgatcggaaa cggcacagca tccagagaaa cagagcaatt 526921 catcgtcaat gtactcagag acatgccgcg caaaatttat tatgtgatcg tcaatgaagc 526981 gggagcaagc gtctattcgg cttcagagct tgccagagaa gaattccctg accttaaggt 527041 tgaagagcgc agtgccgtat ctattgctcg gagacttcaa gacccgctcg cggagctcgt 527101 taagatcgat ccgaagtctg ttggtgtcgg acagtatcag catgacgtca gccaaaaacg 527161 cttaaatgaa tctctgcggt ttgtcgtcga aactgtcgta aaccaggttg gagtaaacgt 527221 caacacagcc tccgccgcgc tgcttcaata tgtagctgga ttatcgaagt ctgtagcagg 527281 caacgttgtc aaaaaacgtg aggaaatcgg aaagttttca aatcgaaaag aactgaagga 527341 catcccaagg ttaggtgcga aaacctatga gcaatgtatc ggtttcttaa gagtgcagga 527401 agggacagag cctttggata gaacaggcat ccacccggaa agctataaag aaacaaaagc 527461 acttttgaaa aaactcggac tttcaacaga acatatcggc acggcggaat tgaaggacaa 527521 aatcaatcag ctggcgctct ctgaaacggc aaaagagctg ggaatcggcg aaatcactct 527581 gaaagacatt tgtgaacagc tgacaaggcc ggaacgcgat ccacgcgata aggtgcctaa 527641 gcctttgctg aaaacagacg tccttcagct ggaagatttg aaagagggaa tggaactgca 527701 gggcaccgtg cgcaatgtag tggacttcgg agcgtttgtt gatatcggag tcaaacaaga 527761 cgggcttgtg catatctcaa aattgagcaa tcaattcgtc aagcatcctc ttgatgtcgt 527821 atctgtcggc gatattgtga cagtttgggt tgacggcgta gatgtacaaa aaggcagagt 527881 atcgctgtct atggtaaaat aaaagcactg cttacgagca gtgttttttc ctatagaaat 527941 accagcattg attcagcagt ttaatttggt aattatcttt ttcaaggaac gctttttgca 528001 tctgcttttt aagccaattt ggcataggct cattcctcct cagcttttat cataagaggg 528061 acagtgatta ccatattgta tgcgaacggt gaattgtccc gttcaatgtt ttttaagtga 528121 ggtgcaccat ggataacaaa gagcttcaaa agctgacaga ggatatttct gaaacatatt 528181 ttaaaaagcc gttccgccat caggcgcttt ttaatgaccg gcttaaaacc actggcggca 528241 ggtacctgtt aacctcccat aacattgaat tgaacagaaa atatttgatt gaacacggca 528301 gggaggaact gattggcatc atcaagcacg agctctgcca ttatcatctt catcttgaag 528361 gaaaagggta caagcacaga gacagagatt ttagaatgct attgcagcag gtcaacgcgc 528421 cgaggttctg tacacccctt aagaaaaaag cggaaaacaa aaaaacttat atgtatatct 528481 gtacgacctg cggccaacag tatataaaga agcgcgccat gaaccctgac agatacagat 528541 gcggaaaatg ccgcggaaaa ataaaaagaa ttttttcgtg aaaaaggttg acgaatatgg 528601 caagcctatg ttacattata aaagtcgtca cgagagataa ataaaaacat ttacctcttg 528661 acactgcaaa tcaaggctga tataataagt cttgtctcat tattccacag tagctcagtg 528721 gtagagctat cggctgttaa ccgatcggtc gcaggttcga atcctgcctg tggagccata 528781 ttggagaagt actcaagtgg ctgaagaggc gcccctgcta agggtgtagg tcgcgtaagc 528841 ggcgcgaggg ttcaaatccc tccttctccg ccataagatt tcgatataag ttctcaacca 528901 tcggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca cgggttcgaa 528961 tcccgtacgg gtcattccat ttcgttgggc tatagccaag cggtaaggca acggactttg 529021 actccgtcat gcgttggttc gaatccagct agcccagcca tttttatttt tgaaatctaa 529081 tagtaagagc cattagctca gttggtagag catctgactt ttaatcagag ggtcgaaggt 529141 tcgagtcctt catggctcac catttgtctt tttgcgggtg tggcggaatt ggcagacgcg 529201 ctagacttag gatctagtgt cttacgacgt gggggttcga gtcccttcac ccgcacttta 529261 tttacaaagt gcacgcaaat ctgttttact aggttaagag cctactaaac cagcacaaca 529321 caatttaatg atcacgcggt cgtggcggaa tggcagacgc gctaggttga gggcctagtg 529381 ggtgaataac ccgtggaggt tcaagtcctc tcggccgcat caatgatacc aagggttttg 529441 acacccttgg tatttttttg tgtttatttt caaatgattt actgcccaca aactgcccac 529501 ttacctaaag taagtcatct aatttatcag ccatttcctt ttgcttgttt ggatataggt 529561 gtccataaac atcaattgtt gtttttacag aaccatgtcc taaacgctct ttaattgtta 529621 tgtaatcttc tccttggtgt attaatagtg caacgtgtga atgtctaaaa tcatgtaaac 529681 gtataggagt aagatcgcta tccttgcaaa agtatttaat tttccgactg aaaatatctt 529741 ttcttgaagg tgtatcttta tattgaaaga tataggtatc atgtgaatgt ctaataccta 529801 attcattaaa caactcttct tgtgcttctt tccaacgttc tagtagctta agcaattttt 529861 tattgatgct aactcgccga atcgaatttt tagtttttgg agtagtaaca acaaattgac 529921 catcaagcca ggtgcacgat ttatgcacat ctatttctaa taagattttg tcaatatctt 529981 tccattgcag ggcgagcatt tcaccacatc ttagtccagt taaaaaagca acagtgtaaa 530041 aggttttaaa caataattga tcttgaggaa ttaaactaat aaattttttg aattcttctg 530101 gtctccaaaa cttcattttc tttcttgtta aaggtaatcg tttaacgttg tcacacggat 530161 ttctttttaa gatttcttca tgtacagctg tatcaaaaat tttgcttaga ctagtcatta 530221 tattattaac cgatttattg cttagacctg tttccattaa atgttttctg aaatcagtta 530281 tttctctatg tgtgattttt tgtatatcag atttcaaaaa gtaatcagat atatgtttgt 530341 ttataatgta cttctgattc tgataatagt ttggtttact atctatttca caacttgcta 530401 aataaattga aattagagtc ggaaagctta ctgatctgga ctttcttgct ctttcttctt 530461 gaaattctct tcttaatttt gcttctaatt ctaaagcctc ttttctggtt gatgctactg 530521 gtctcgtcct aattctttct ccagtaatcg ggtcaaatcc aaagctaacg tcaacttgat 530581 attgaccatt ttcaagtttt tttacagaca ttttatttct cctttaacca aaagcgctta 530641 tttcgtgtga atagattctg ttactaaatg agccaatttg agaaagttta taatcagtaa 530701 caaatgatgg tacgttgaag tatgctgcta tttgttcttt gctaaaaccc tgtatatatg 530761 gaagggcttc attaagcatt ttatctgtca gtattaattc tgatgcaaat aggcttgctt 530821 gatgctcaag tttatctttt agaactttag agcaattcac aactttaaaa gtgttcaatc 530881 ttttatggag aaagtaatgc cctaattcat gggcaattac aaattgttga tgttggaggt 530941 tctcgttgat atggattaaa tattgatctg tggctttgtc atgttgtagt aaaccgtttg 531001 cttgtccaag atcatttttg agtatataaa ttttttggat gtcacaaatt tcatagacat 531061 tatttgtacc atgtgtctta attactgatt gcactttatg tttaattcct ttgcttgtat 531121 aaattgttat cactctttct tctttaattc gtcaatgaat ttaattccgt tttttaatgc 531181 ttttttaaca aggcgtgcag tttcctcatc aaattcacca tcattcataa aaaggagtgt 531241 atcttcatcc tttaattcct gtatggcttc attaattgtt ttattgagta aatcagtttc 531301 gtttttcttg cttacttcat cctttcctaa taaatagtct gtagatacgt tatataagtt 531361 gctcaatttt aagagtgtgt ctgtatcagg atctctgtaa tctctttcgt aattagacaa 531421 gttattgtta ccgatattaa gtttctctgc ggcttctttc tgagtgtacc cagctttttg 531481 tcgagcttct tttaatcgtt tgcctaggct catttttatc atccatttca caaagagttg 531541 atttttataa aaataataac aacatttttt ggagaattca ttaatttcac ctataagtta 531601 aataaataat tctaaattct ccttttagga gtgtttgttt cttctttatg gagagtttaa 531661 ttatcaatat ttccatatat gttcaaaaaa atacacttta aggtgaattt tgtgttgact 531721 tacacgaaaa ggagttttat aataaagtta attcacaaag agttgagtta acgaggaggt 531781 gatattttga aaggagagtt tttaactgcg agagatattc aaaaaattct tggagttaaa 531841 caggctaaat cttatgacat cattagaact ttgaatgctc aaatgaaaga agaaggatat 531901 atggtcattc aaggtaaggt gagtagagct aagtttgaag agtgttattg ttacaaaggc 531961 ccaaaatctc aaacggggtg atttttataa acattgatat aacaaactcg tttatgaaag 532021 aagctgtccc tttagctaga caaatggaag gtgattggat agcacgaatg aaaattgctc 532081 tgaattcagt cattataaat cattatttaa accttccctt aacaattgaa aatgttaatg 532141 aattactgcg aaaaggcgtt tcatatcgca ggatatgtaa gcattacggc attggaagaa 532201 aagacattga aaagcttcgg caatcatccg tagtgtgacg ttatatacca ctatagggag 532261 ccgttaagaa tcctttgaaa ggagggatgc gatgaaaata agagtgaatg caacaatcat 532321 tactgatgtt gaagctttaa aggctgataa ggatttgaat cattttaaag actatgccac 532381 ttgtgaaaca ttcgttgttg atgctgataa tcatttgaag gctaatgaag aaatatctga 532441 gttgttaaaa ggctgggatt ggtggtgtat ctggtcaact cgtccattga gtaaaaagga 532501 taaccaagtg tttactttgt ataacgatga tttgtataac ttatgtcgat aggagtgttt 532561 gttccttgaa aactacatat agacaaaaaa agcgccttga cgaatgatca tcaagaacgc 532621 cggaaaataa aaactagaca cttttattat acggtattct tgttgaaatg tcatgcgtga 532681 gtatttgagt gatgaacagc aatcacttta aatgctgtag caggctagaa taagcgtgcg 532741 gaatagctgt agtcagcttg atggctataa ttagcctact aggttgccat gagggcgtaa 532801 agccgttagc aactgataag cgccaagatg gatacagaac cggagcgaat caaaaacata 532861 aaatcgaaat taatgttctt ttgtaaataa attataaaaa aatgaaatgg ggatatgaaa 532921 aatgaactta aactttattg taccggatat caatatgact tttggagaca tgaaattcat 532981 gggacttaac agagaaaggt atgtttatga tcgtgaaaat aataagcgta ctgacgtact 533041 ggaatctagg atttataaca ttgctagtgc tgtccaaggt ggtcaaattg aagtaactat 533101 tcctgagtat gctggggcaa aagaaattcc tccttttgca gatattgagt tgaaaaatcc 533161 aaaaattagc gctatggcga ctagtcaaag ggattcgacg tatgccaatg tgatgtggaa 533221 acttgaagct gatgatattg ttgttaaagg tggctcttct gtgaaacctg ccgcggcaac 533281 tggcgggaat gaaaagaaat aacatgatgc tctcatatcg gcaggcgggt gatgtatatg 533341 agtgatttct taaacaaaag attttggaaa tacaggggca aacgaatccg cccgtacatg 533401 agaaacaacg taaagttagc aggcgcaatc atctttgtgc ctgttttttt attgtctatg 533461 ttcctttttt ggagagaaca actcattcat tttgatctat ctcaagtgat aaaaaatttt 533521 gaatggaatg tgcctttaat cattaaaagc gttttatgct ctgtgctaat tgctgttgga 533581 agcatagttg catcttactt tcttttgttt gacagctata agaaaatcct tcacaggcaa 533641 aagattgcta aaatgatttt ctctaacaag ttttacgaaa aagaaaacgt gaaagtaaga 533701 aaaatctttt caaatgaaac tgactcaaag gaaaagatca catactttcc tagaatgtat 533761 taccaggtca aaaacaacca catctatatt cgtattgcta tggacatgag ccgttttcag 533821 aatcgcttcc tagacttagg aaaggatttg gaaaacggct tattttgtga cttggttgat 533881 aaacaaatgg aagaaggttt tgtatgcttt aagcttcttt acgatgtcaa aaagaatcgt 533941 atttccattg atgatgcagt agctgagaat ggagtccttc cgttaatgaa gcatatctca 534001 tggcaatttg ataagttgcc gcacatgctt attgctggtg gtacaggtgg agggaaaaca 534061 tacttcatgc taacgatcat taaggcatgt gttggactgg gggcagatgt aagaatacta 534121 gaccctaaaa atgcagattt agcagacttg gaagaagtac ttccgaaaaa ggtctattcc 534181 caaaagaacg gtattcttat gtgcctgaga aagtctgtag atggcatgat ggaacgaatg 534241 gatgaaatga agcaaatgtc taactataag acaggtgaaa actatgctta tttaggctta 534301 aaacctgttt ttatcttctt tgatgaatat gtggcattta tggatttgtt agatatgaaa 534361 gaaagaaacg aagccctttc ttacatgaaa cagttggtca tgttggggag acaggcgggg 534421 tattttctcg ttttaggcgc acaacgtcca gatgcaaaat atttagctga cggtattcgt 534481 gatcagttta gctttcgtgt ttcattgggt ttaatgtccg atacgggtta cggaatgatg 534541 tttggcgatg ttgaaaaagc atatgtgaat aaaaaggaga cagggcgagg atatgccaat 534601 gtgggcacag gttcagtgtt ggagttttac agccctatcg tgccgaaagg atatgatttt 534661 atgtcatcta ttaaaaatgc gctggttgga gtcgagggag cgcaggcgac ggcagtcgcc 534721 agcggcagcg taagcgacca gacggccagc ggcgaaggag tgagcgaagc gaatggatga 534781 gctaaaacaa cccccccacg ctaacagggg ggtagtaatc gtaaaagaaa aaaatgaagc 534841 cgttgaaagt cctttggtat caatggttga ctatattcga gtctctttta aaactcatga 534901 tgttgacaga attattgaag aggttcttca ccttagcaaa gactttatga ctgagaaaca 534961 atctggtttc tatggctacg ttggcacgta tgaactggac tatatcaaag tcttttattc 535021 tgcgccggat gacaacagag gtgttttgat agaaatgtcc ggtcaaggtt gccgtcaatt 535081 tgaatccttc ttggaatgcc ggaagaaaac atggtacgac ttctttcaag attgcatgca 535141 acaaggcggt tcgttcactc gctttgattt agctattgat gataaaaaga catacttttc 535201 tataccagaa ctgttaaaga aagcccaaaa gggcgaatgt atttcacgat ttagaaaatc 535261 tgatttcaat ggctcctttg atctatctga tggcattaca ggcgggacga caatatattt 535321 cggttctaaa aagtcagaag cgtacctttg cttttatgag aaaaactatg aacaagcaga 535381 aaagtataac attccgttag aagaactagg cgattggaat cgttatgaat tgcggcttaa 535441 aaatgaacgt gcacaagtgg cgatagatgc tttattgaaa acaaaggatt taaccttaat 535501 cgctatgcag atcattaata actatgtaag gttcgttgat gctgatgaaa acatcactag 535561 agagcattgg aaaacgagcc ttttttggtc tgattttata ggcgatgttg ggagacttcc 535621 tttgtacgtc aaaccacaaa aagacttcta tcagaaatca agaaactggc ttcgtaactc 535681 ttgtgctccc actatgaaaa tggtgcttga agctgatgaa catttaggga aaaccgatct 535741 gtcagatatg attgcagaag ctgaactggc tgacaaacat aaaaaaatgt tagatgtgta 535801 tatggctgat gttgctgaca tggtcgttta aaaccaagct gctaaacctt aataaacaca 535861 ggtgatgcga ttaaacgtat gtgtcaacgg taccggaacg aagtgaggat aaggagttga 535921 catattcagc gctacccaaa ccctcttggc attgaacaaa caaccgtttg ttcctgccta 535981 ccggcgaggg agtcccccga tgattcgggg gaataggggg atagattaac agcaatccaa 536041 cgagctaccg ttggtgggtt tgggtgaaac ccaagaacta acttggaggg ataagatgca 536101 taatgtcaat ctgttgaatc aggctggact ggaaaatgct ttggaatcag ttggctgttt 536161 agatattgta gaagatttaa tagaaaagat gcaggaatat gttttgtatc ataccgaaac 536221 tgccgaaaga tttgcgattg atatctttac agtagtaaac aactacacta aaaaggttca 536281 tgcgatattt aatgttcttg aaaatgaaga cggtgagaca aatgttaaaa atgtagaatt 536341 tgaagtaatg cattttacgg agtaaggaca attttcctta tgactttaaa gggggaacat 536401 caggtgttta atattaatct gttgaatcag gcccgacttg agagtgattt ggattccctt 536461 gggtgtttgg atattgctga ggaactgatt gaaaaaatga tggaagatgt tttttacagt 536521 gatgtagctc aaagaatcat tgttcaaaca cttgctgtta taaataacgc caatgcaaaa 536581 cttcaagcta cgtttaacat cttagaagat gaagatatgg agacagacga acgaagcgtg 536641 gagtttgaag gaattagcta ctacgaataa ggggtgaaaa tgtgcggtgt ctgctgtaga 536701 taaacgattc aaaagcttag gttttaatgt gggcattccc tctttagttt ttgtgagaag 536761 tttaagcaga gattgcatgt tggttgttga aggagaacga gtaaaaggat ttgctgagta 536821 tcgttacaca ttctataaaa caagatactt gccagacggt cgaatgacta gcttaaaagt 536881 ttatatggag aatcaaagca taaaaagggt gttacatcgt gtagcatcct ttttatcttt 536941 cttggaaaga acgaaacaaa ttgaacagaa ggagtgtgaa aaagttgctc aataaagaaa 537001 ttggctctga taagaaggaa gaatcctttt ttcggtctgc ttttcaaaaa ctgaaacgaa 537061 ttgaaagacc ggaaaaagac aaacaaaaag taccccgtga caggtcaaag ctgatagccg 537121 tcacactatg gtcttgtgta gggagcttgc tatttatctg tctgcttgct gtgcttctgt 537181 caattaatac tcgctcccaa cttaatgaca tgaaagacga aacgaataag ccaacaaatg 537241 acgataaaca aaaaatttcg gtgactgctg ccgaaaactt tctgtcaggg ttcatcaatg 537301 aatatatgaa tgtgaagaac gatcaagaat ctattgaaaa acgtatgcag agccttgaaa 537361 gctatatggt taaacaggaa gataaccatt ttgaagatga agaacgcttc aatgtggatg 537421 gtttaaaagg tgatcgagag ttaaagggtt acagcttata taacgtgaaa gaaggtgata 537481 aaaacagcct ttttcaatat aaggtcacat atgaaaatct ataccctgta gaaaaggaag 537541 ttgaaaaaga agttaaagac ggaaagaaga aaaagaaggt gaaagaaaag gttaaaacaa 537601 acgagaaata cgaaaaacaa atgttgctga atattccagt cacaaataaa ggtgattcct 537661 ttgcggtgtc tgctgtccct tattttacac agatttatga tctgaaaggc gatattgctt 537721 ttaagggtaa agaagaaact agagacgaat atgcaggcga gaaaaaagaa tctatcgaat 537781 catttcttca aaatttcttt gagaaatacg cttctgaaaa gaaagaagaa atggtttata 537841 tgatgaaaaa gccggaagca ttggaaggaa acttgttatt tggggaagtg cagtcagtga 537901 aaatcttcga gacgaaaaaa ggtttcgagg ttttttgtgc tgttcgattt aaggaaaaag 537961 aaaatgacat tccggtaaat gaaaaattca gtctagagat tacggaaaac agcggtcagt 538021 tttatgtaaa taaactcaaa catcaatagg aggtttaaat atggatttca tgaatttctt 538081 tattcttggc gcagaccttc caacacttgg aggggtaaaa ggttgggcat cagatgttgt 538141 tatccaattc attacgattg tggtcatgtt catagccgca aagaatctga tgaaattaaa 538201 aatgggcggc attatctttg tttgctgtat tggcagtgcg gtaacgtggg ttattaaaca 538261 ctggtcagaa ttctccggct ggatcaatgc gctaatggaa aaattgtaag ggggcatctg 538321 aatggggcgt ctggtgttca actaccggaa ggcaatgaga gagccgaaaa aaatccaaca 538381 attaaccgaa aattattcgt taccctttgc agttgagtta ataccggcta ttaactattt 538441 catttttgtt ggcttatgct ttggattctg gtacggcgtg aggatgattt tccctcacgc 538501 ttttgataac agttacgtca ttgtgatttt tgggatacca ttttttttaa cgatgcttgt 538561 aacgaaaata aagccggaag gcaaaaacat ctatatatat ttctttgatt tcgcaaagta 538621 ttacttcttc atcaagcttc cacaaaagaa gtattgcaat gatcgaaaga ttgatttaag 538681 taacgaaaaa caaattgagt ttcgaaaact tgtgaaggtg gtggattatt caaatgagac 538741 taaaaacgcc tatgaaggca atacacaaga atttgctgtt aacaagaacg ggcgacgtgt 538801 gggcgtacta ccgaataaaa agcaattcga ttcctatgca aaataaagaa aaagttgaat 538861 cgtataaaaa gaagtggcag catctttttg aagaaattac atcttatgag gattttcact 538921 tgatgatgta tccaagtgag tatgaattag aaaaacgatt taaggattta gaaacagata 538981 ttgcggcaga tgcaatggat gtggcacgtt actacaatga agaaaccgta aggctgttag 539041 aacagcgatt aggaaggctg acaaagtacg acttcatttt aggtgtaaaa ctgaaaagca 539101 gtcttgtaaa tattagtgtc gaacttaaag acaatatact atcttttttc aatacagcga 539161 ctgatacagt cgtgaaaatg ctcgggtggg aacaaaatgt ttccacctct ttttttgaaa 539221 aatatgagga agtcgaagaa acactagcga atatcatggc ttctgttcgc ggagaacggc 539281 tttcagaaac agaaatgaca tacattaacc gttatcactt tgtacgtggg ttaaagcacc 539341 aaacgaatga agaaagtgag ataaaggatg ttcgctctat tacaaacacg atcatagacc 539401 ccactgaccc atcagtattg catttgcata gtgatcaaga tgaaggctat tcagcttttg 539461 tcgtgattga cgaatttctt cacaatatgt cggaaagtga tttgttttat gaagcacagt 539521 ctcttccctt ccctgttgaa gttcagatga aaattcaaac ggaatcaaag tccattacca 539581 agcctgccct caacctcaaa agacagcaat tgaaagaaga acaaaaagaa caacaaagca 539641 caggcgatcg aagtgatgtt tccactgtca caagtgccac aatgataagg catttacaag 539701 atgaaataaa gaaagaagat gtgcatgtga tgaactggct gtcggtgata gtcgttcatg 539761 gaaagacaaa aaaagaatgt gtgggaaaag caacgattgt caaaaggcat ttaaaaggcg 539821 ctggcattac ttgtcggctt ccggtggctg atcaattgaa ccttttttat aaaatgcttc 539881 ctggtgaaaa gttagacata accgataaga actggattca aaaaacaacg caagacggtg 539941 tggctgaaag tctgtttgct gttaactctg atattggttc gaaaatcggg ttctttctcg 540001 gttgggttga tcgtttccaa gagcacaccg acttagaaag tgccattatg tccagccgtg 540061 attttgtctt attccaccct ttcttagcga atcagcagtt aaaaggttca aagacacgtt 540121 ctcctcactg cttaatcaca ggagacacag gaaacggcaa gtcatatcta gcgaaattga 540181 tctttaacta tatcagcatg ttaaacatca aatctctgta tatagaccct aaaaaggaaa 540241 tgagaaagtg gattcaaaga gtcttgaatg atgagtacat tagagagaac tttcccttat 540301 atattgcaca tttagagaaa tacaactata tcacgctaga tcatgaaaac acgcacaact 540361 ggggagcgct tgaccctatc tccttcctcc ctcctatgaa agcaaaagag ctagttcaag 540421 tcatttttga acaagtatat gactttaaag ggaaggacga cataaacaca gctttccttc 540481 gtgctacgtc agaagtgatt gatgcgaaac aaaaaggtga acaggtcggc tcacttgata 540541 ttattcggaa gatgcagagc catcccgaag aagctgtaca aaaagctggt gactatttaa 540601 atgaggtcgt gtcagattcc attttgaaac tttgtattca tgatggttca aatcctgcat 540661 tgtcactaga aaagcgaatt accattttag aagttgaaaa tatggatttg ccggatcatg 540721 ctgagcgact tgaaaactac acgatatcac aactaaagtc tagtgcggtc atgtttgcac 540781 taggtaagtt ctgcgagcta ttcggcatga atcaagacga acagactgtt gaatttatag 540841 atgaagcttg gatattcacc acgtcacaac aaggaaaaaa agtagaaaga caaatgcgcc 540901 ggattggtcg ctcatacaac aatgcggaat acttcatttc tcaatccaca aaagacgctt 540961 taaaagaaga ggattctgga aactttggcg ttgcctttgc ttttgacgaa ccaaacgagc 541021 gtgaagaagt gttgaaatgg atgaacatgg aggtcacaaa agataacaaa aaaatgatgg 541081 aatccatgtt tcaaggtcaa tgcttattta aagattacta tggccgcacc tctaaaattt 541141 cgattgaatg cctattcgaa gaatggcaag gtgctctgaa aacagttgag aaaaaagccg 541201 tcgcatatgc ggaagaaaaa tatttgtaaa aaggggttga atcgtacatg gaaatagctt 541261 tcttaaactc tcttgttgtc acgagtccag gcttttataa agctgagaaa atcacattgg 541321 acgaagttaa acaatggctg aagcattatg atggtcgata caaaagtttt atcggacata 541381 aatcaacggc acagtttctg caaaaattat taggtatcag aattgagcaa aatcgaaaga 541441 ctttcagaca tatgaaatat caaaaagcaa tctgtttctc tctgtatgaa cgatatcctg 541501 aaaacgtgtt gctaacgcaa agagacttag agaaagccag ataccaattt tatttattaa 541561 ctcggttaga ttaggaggtg gttgtaatga aaaagaaaag aattttgatt gtgtcggcta 541621 ttgtgttgct gtttttaact gttgcttcag ctgtaacggt attttcggct gatggagata 541681 caacgacgca gccaaaagtc gaaaaagctg gcggcgtgga attgaaggtg aaaaggtttc 541741 caatctcacg ctatcaagcg aataatgaag catctgacga tttaatcaag ggggcgtttg 541801 ttgggctgac aaacgtcact ttttcttttg cgggaaacat tgtccgtgtg gttgatacgg 541861 ggatggatat tttgtataac ttgcaaccga ttgacgagtt cgcaaattct attacaaacg 541921 tctctaaaac agtttataaa acactgaaaa agaatttcgg tgaagcttta tttattttca 541981 cgtgcgccta tgttgtctac ctattctgtg tgagaggtag cgtaaaagaa gcaatgcggc 542041 ggagtattct atttatttgt gtcatggtga tcggtgggct ttggatgtcg aacgctggtt 542101 attacatgaa agtattgaat gccttgtctg tagaagctca aggaaagctt ttaactgcgg 542161 ggaatggatt ggttggcatt gttcaagatg aaggcaattt tgcagacagt tcagcgattg 542221 aaaaaggaaa agaaatggaa ggcacagttg cggttatgcg taatctttac tttgacattg 542281 ctttgatgaa gcctttttta attgtgaatt ttgatgaaac aagcgaaaag aaaatcaatg 542341 aggaagatac agataaaggc ggacttaatc gtatagataa actgctttct tataagcttt 542401 cagaggatgg agaaaaagat aaaaaagatt atataaaaga gactgaaatt gatgattata 542461 aaaatgaatc tatgacttct ggaaatgtgt ttaatcagct gggagagtct tttatcgctg 542521 tggtcgcttc tattgtcatt gggataccat ttttagcatt agcgttcttt aatttcttgc 542581 ttcaagttgt cgctttagtg atagttttct ttgtgccatt tgctttcatc ttagcgtatg 542641 ttcctcaatt agcttattcg ggatttgtta cgcttggacg cttggggagt gtttacctac 542701 tgaaagcaat gttaggggtt atcgttctgt ttgtgtacgt gacttgtttt attgttgaca 542761 agttaatacc gccaaatggt tttggaatgt atcttttaaa tgttgctgtc cttgcttcaa 542821 tcttgtggat tggttttcac aagagggatg ccattatcaa gtttgtgact gctggaaaag 542881 ttgtttcagt tgataataat atgatggaaa acatgagaca aaacattgtt cagcctgctt 542941 gggaacaagc gaagaaaata ggtggagtat ggggtaacgg aggcggcgta tttactgact 543001 ttacaaagca ttttggggga agaaaagacg gttcgaatgc tgatggcgta actggtgctc 543061 caagtggtgg cggtaattca ccgagtggga ctgctatggg atatgataat actcatgcta 543121 tttcaagaac cccgcaaaaa gaaacagcta acggaatagc taatcataac agtcgaagct 543181 taaaacgcaa tcctcaaact ctatcgaaag aacaagaaaa gcaaaaacaa aaagaagcct 543241 ttgcaaatgc aaaagaaaat aaacagcaat cccatttagc cagattgaga aaagacggaa 543301 taaactctcc tatgttgaaa gatgctttga atgaagggaa tgaggattta tccaaacgag 543361 cacctatctt gcaggataaa aaagatgaat cagcacgaac agatcaaaaa gaatatgtgg 543421 aacagcttct taaacagccc aataaccagc aacaaactga cgatgcatca ttacagcatg 543481 aagaagaatc tacttctaat cgtgcgcctg tcttacaaga gaatgaaaaa gatacagaac 543541 gtactgatca gaaagcgtat atttatgacg aacaaaatca gaatcttgaa acagatcagc 543601 aacaagattt tgaagtccag aaagatgatt ctgtttccaa tagtgagcct gtagcacaag 543661 agaaaacagc agaaatcaaa cgatcagatc aaaaagtcat gatgaatcaa cctgaaccgc 543721 agctcggttt tgaaagtcct caatctacaa aagtagaaaa tcaacctatt gccaataacg 543781 aacgtaaaat cagaccatct gaacccgcaa aagttcattc agatggtatt cgtgttgatg 543841 aaaaacaggc tgttgctcct gctgaaaata agactgtatc aagagaaaaa cagccttcat 543901 cacaaacaat taaacggact gaacaaagcg ttaattcatt tgaccaagtg tctttgaatg 543961 aaattgcaag acgctcttca tcaaaagtag aagatcgact gagaagggat gaaagaacaa 544021 gatgataagt aaaaaggtag ttcttccttt ggtattctcg gctcctttta tcttcttttt 544081 tgttttatgt atcgtagtgg ttatgacgat ttcaagagaa aatcaagtcg gggacgattt 544141 tataggcggc ggggatggcg aatatgaaac agttggaatt gcgccggaag tggaacgatt 544201 tagagcagta tttgagaaat atgcccgtca agaaggcgtt tttgaccaag tgaatattat 544261 tatggcgctc accatgcaag aaagtggtgg gcgttcttta gatatcatgc aaagttccga 544321 aagtatcggc ttacctccca actccataac tgacccagaa cgttcaattg aagtcggcat 544381 taaacatttt aagaaggttt ttaaacaggc tggcggtgat gttcgtttaa ccttacaggc 544441 atacaacttt ggttctggat ttatagacta tgtcaaaaag aatggcggga aatacacaaa 544501 gaaattagca cttgatttca gccgattgca agcttttaaa atgggctgga aaagctacgg 544561 tgacccaagt tatgttgacc atgtcatgag gtatgtgaaa ggctctgata aaaatgtgaa 544621 gcctgtgaaa ggctctatgg atttctatga aacggtcatg aaagaagctt tgaaatatga 544681 agggcaaccg tatgcctggg gaggttcaaa cccggaaact ggatttgatt gttctggcct 544741 tgttcagtgg tcttttgcga aagctggaat cactcttcct agaacagcac aagaacaaca 544801 tggggcaacc aagaaaataa gtgaaaaaga agcgactgcg ggtgacttag tgttctttgg 544861 cggcacatac gaaggaaaag ccattactca cgtcggcatc tatgtaggca atggcagaat 544921 gtttaattca aatgacagtg gaatccaata ttctgatctg aaatcaggtt actggagaga 544981 tcaccttgta tcttttggac gcattaaata actaggagtg aaaatatgaa aacacatatt 545041 gcatgggctt cagcttgttt attattagtc atgttaactg gatttttcac gattggacag 545101 caaacgtata agattgaaaa gttaaaagat aaaaatgaag ttttgagcga aaaaattaag 545161 gaattgaacc atatagaatc aacaagtagc gcttcggaaa ataaggcatt ttttgaagcg 545221 ttttttaatt actccgacat agatatacga tatgaaacag ttaagaagca cacaactgga 545281 aaagggtttg attatgcatt cccttctcgt tctgatcaaa agcacacagt cagcgtgcaa 545341 agtgaattac tatcactaga gagttattca aagccgttag atgagtctca tgaattgttt 545401 ttaaacattg ttgaagtcgc cacaactgca aattcagtca ctacgaatca agtgttaatt 545461 gtacaaacga ctatgaaaaa agaaaaggat ggttggttag tcgataatgt gcaggttaag 545521 ggaaatggat aaaaggtgga aaagatcaat ttgtttgttt atactaaata ttgaaaaagg 545581 aggtaatgtt tattttgaaa aaccttttta ttttccttag tttgatgatg atgtttgttt 545641 taactgcatg tggtggaagc aagtatgatg atgcgattga tgatgtaatt agccaatata 545701 aagagcataa aggaaatgac acagagataa atattaaaag agagaatgcg attgttagag 545761 tctatgaagg gggcaaatat attcagtttg cattttatat gccggataac tcttcacgtg 545821 aattaacaac atttaagtat tatgaaaaat ttggagataa atatgaaaag atgactgata 545881 tgccggggaa tggggaaaat gatcgtctgg ggttatcaaa gaaaacacca gactatgaag 545941 aagtaaaagg agaagagaca gagttagagg agtaaaccgt gtgtttactc ctcttttagt 546001 tttattgaca ttggtaaaac agagataggg taagaactta gctaattaag aatgaaaatt 546061 ataaggttta taagttggaa actaaatcaa atatgtcttc taagaataga tttatgggta 546121 aaagttgttt ttacactatt ggtgctacta gcagtggcat ttaagttatt ttaatttcgt 546181 attaaattta gcctttatcc tttcccattt tttatcttct aatgtgagat catacatacg 546241 gagtattttt tcttttaaat taaataagtc tattggttcc tccaaggaga atgctttttt 546301 atttttatca attactcctt ttatttcgcc cttaaaacca gggaggatga aagtagagca 546361 gttattgcta ttcacccaag tagcccccat ttcattaagg cagtatacgc tatcatagta 546421 attatcggat aacatataaa agacatatgc acccttaaaa agatgttttt ttagatattc 546481 gaaaatatct tcatctccag gaataccatg ataaggtgaa gaagtgtata ttatatcttc 546541 agaagacact cctatatcct ctagtaattc aacgaaagca ttacatacaa ttttgtcttt 546601 tgaggagtgg ctaataaata tttttttctc taattctcta ttttgatcac ttgaaaagtg 546661 agttatgctg cttttttcag tctcatctac tacaggcaat tcatctaaaa atttttttat 546721 tttattttct gtttcatgat gttcaaactc attaaaaaca aattcatttt tatatatttc 546781 attgcggttt cgtgcatacc aagtcttaag ttgttctagt gaataacgaa ttaactcaat 546841 atcatttgat tcaagagatg ttcgaaattg atcaataata tttgtgagta caggctcgcg 546901 agagtaatct agaagtactc ctataattcc attagcctca aattttaatt tttttaatgt 546961 gtccattaga tttcctccga cctaatttaa tccattgttt gtaaacattt catatctaat 547021 tatataacat agactcctat tctaactact tattttaaag cagtctggat tgtttgggta 547081 attcataaaa aaataaaaga aagaaggagg aatagagttt ttcttttttt tgtttgcaat 547141 gttactgtca agtcgcaaaa gaattgctat gaccgaaaaa aaaccgcaaa ggaatagata 547201 taaggtacct ttttgcaatt catctttgta aaataaaggt tattctgaca taatacaatt 547261 aatgtaaaaa ttcgcacaat tttatgtaag gatgggggaa ttttcttgcg gggtgttttc 547321 ttagataaag ataaaattcc gtacgactta gtcacgaaaa agttaaatga atggtataca 547381 tcaataaaaa atgatcaagt tgagcaagcc gagattataa aaacagaagt agagaaagaa 547441 ttgttaaaca tggaagaaaa tcaagatgcc ctgttatatt atcaactatt agaatttaga 547501 catgagataa tgctgagtta tatgaaatct aaggaaatag aagatctcaa taatgcttat 547561 gagactataa aagaaattga gaagcaaggg caattaactg gcatgttgga atactatttt 547621 tactttttta agggtatgta cgagtttagg cgtaaagaat taatttcagc gataagtgct 547681 tatcgaatag ctgaatcaaa gttgtcagaa gttgaggatg aaatagagaa agcagagttt 547741 tttttcaaag tgtcctatgt atattattat atgaaacaaa catacttctc catgaattat 547801 gcaaatcgtg cactcaaaat atttagagag tatgaagaat atgctgtcca gactgtgcgt 547861 tgtcaattta ttgtagcagg aaacttgatc gattcattgg aatatgaaag agccttggaa 547921 caatttttga agtctttgga aatttccaag gaaagtaaca tagagcattt aattgcaatg 547981 tcacatatga atattgggat ttgttatgat gaattgaaag aatataagaa ggcttcacaa 548041 catttaattt tagcgttaga aatttttgaa aaatcaaaac atagtttctt aacaaagact 548101 ttattcactc taacctatgt agaagcaaaa caacaaaatt ataatgttgc tttgatatac 548161 tttaggaaag ggcgatttat tgccgataaa agtgatgata aggaatactc agcgaaattc 548221 aaaatattag agggattatt tttttctgat ggtgagactc aattaataaa gaatgcattt 548281 tcatatctgg cttcgagaaa aatgtttgct gatgttgaaa atttttcgat tgaagtcgct 548341 gattattttc atgaacaagg aaatttaatg ctctctaatg aatattatcg tatgagtatt 548401 gaagcaagac gaaaaattaa aaaaggggag attattgatg aaaatcagcc ggattctatt 548461 ggcagcagtg attttaagta gtgtattttc aataacttat ttgcaaagtg atcataatac 548521 tgaaattaaa gttgctgcag atcgggtagg ggcatagctt agataattgg aaaagaggaa 548581 aaaagcttaa tcttttttcg aaggttaagc tttttctttt atttataaaa agtgaactaa 548641 ctatcagaaa gaaattatat taaattttat ttttttgttt aaaaagtaga ttatataaag 548701 gcaagctagg tgggggaaaa tatgtttaaa aaagaaaaag tcacagaata catttggact 548761 atactaatac caacaatcat cacttttatc attagttggg ttgggtctta ttacaatggt 548821 acttcgacag ttagtattgg acaacctaca aaagtttccg gtcagtatat cacgccaata 548881 aatataagtc cctatcatga tattaaggaa ttaagaataa cttttccgca aaaactagat 548941 gtaaaacaaa ttagttcaaa tgagcctata aatgtaaaat cagataagaa caatatagga 549001 gttgaaagta attccacttt tgagattgcg aaaatcgttg aaaataatag cgttcagttg 549061 ctaattacaa cacaaaaaaa gttaaacgat aaggaaatta gaattgataa aaatggaaat 549121 aacatttctg taaattatga atctcagatt gttaatcctg caaaaaaaca attaatcaat 549181 cttataatta cgtcatctat ttattttata atgcttaata tactagcatt gattatgaac 549241 aaaagatggg ataagtatta tgcaaaaatg aaaaatgaaa tcaaagaatt tgaggataat 549301 gcaaaagatc ttgataaaaa atcaaagaag aaaagcgagg aattatcgga gctgcgaaag 549361 accttgaacc aagcgtttga ggaaactgat aggataaaat atcatgagaa gaaaaaacaa 549421 atcctcctct tagctaagtt aaacgattat aaaaaagaac taaccttttg gagaaataca 549481 ataagaaaag ttctttatga acttcctgat ggagataaaa aagcagataa actaataggg 549541 acagttacat catctttaaa aacgtacggt acagtcgaaa aaaacgagca tgattatgaa 549601 agtttaaaag tagcagctgc cttactaaat gattctgata agagatcgta atgtactgga 549661 ttttaataaa ctattagaaa gaagattagc tgcaaacatc agaacgacca aacaatggtg 549721 gtatgtttat agagtttagt tgttgaaaag ggcgaactat gagtttgctg cccatttact 549781 gcccagaata aataacaaat catgaaaatc agtgtaaata aaataactta atgctataaa 549841 taaaggcttt tgtaaataaa gatatgattt tactaggttg agggcctagt gggtgaataa 549901 cccgtggagg ttcaagtcct ctcggccgca tctcaataat accaagggtt taaccacctt 549961 tggtattatt tttttgtgtg gaaaatacgg ctatgggaga agacttgctc accaaaactc 550021 accagttact taaagtaagt catccaaacg gtcggcggtt ccttctgttt attaggaaaa 550081 agatatccgt tcattgtaaa agaaacgaac catgtcctat tcgttcaaaa aaactaaagg 550141 gtgatacata ttatacatga ttaatatgta tcaccctttt ctttcttgtt caacaatcgc 550201 gcttgaggag aacataagct aatacaactg actcgatttc taaagttgct ccattctttt 550261 tttaaacaac tcatccacaa cctgttttaa aatctcgtac gactgaattt ccttgctcaa 550321 ttcgtaaata ttagataaca caattaattc atctgcgtga tacatttgtt ggaaatcaat 550381 tagttcgcga cgaattgttt ctcgatcacc catgattgta taccccagtc gactgtggag 550441 aatttctaat tcaaactgtg ataacgattc taggaagttt tcagtgggtg gaataagctt 550501 acttaaatta tttgtataaa tatcaatata cacctgcaaa tgacttgcag aaataaaaga 550561 tgcctcgtct atagattctg ctgcaatcac attaatgcaa gcgatcacat aaggttcttg 550621 taaataagaa gacggttgga aattttctcg ataaatagag agcgcttctt ccatcgaatg 550681 gggtgaaaat tgagcgccaa atgcataggg taaaccaagc tttgcagcaa tttccgctga 550741 atccgttgag gatcctaaca caaaaacagg cacatgcgtt ccaatacccg gataagcgcg 550801 aacctcaccc tgtacactct tatccccgac aaaacgcaaa atatcattta cttctctttc 550861 aaagaaaaac actccattat ggttggaacg acgaatcaca tcggccgttt tttgatccgt 550921 tccgggtgcg cgtcctaatg ccaaatctac acgatttgga tataatgttt caagtgttcc 550981 aaattgctcc gctacgatta atggggaatg atttggcaac ataatacccc ctgaacctac 551041 gcgaatgtct tttgtatttg ctaatatatg ttgtacaatt gatacggttg ctgcacttgc 551101 ataagcgtcg tgattatgat gctctgcaaa ccaaatccgt ttatagccca tattatctac 551161 agctttagct aatgacactg cagaatcaat cccttgtttc attgtttctc cttgtcttaa 551221 tggagcaact gataaaacag atatatcaaa ttttttcata atttcacctc taaaataatg 551281 aacttataca agatcaatgg aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc 551341 cattcctctt tgatttgcat gcaaataaat atatactttc tcaaacgatc aatacatagg 551401 caaaataaag ttatttcaca atttcacttt acttttaaag ttttaagcaa acataaaaaa 551461 atgttcagtg aacaaaatat gtaaaataca tcttattttt cagaaaggat acaagaaaat 551521 gattgatgaa atagataaaa aaatacttga tgagctgtct aaaaatagtc gccttacaat 551581 gaaaaaatta ggggaaaaag tacatctcac tgcaccagca accgcatcaa gagtagtaaa 551641 gttaatagac aatggcataa taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg 551701 cttctctata catgcttttc ttaatattta tatcgaaaaa atccatcatc aaccctattt 551761 agcttttata gaaacacaag ataactatgt aataaacaat tataaagtta gtggagacgg 551821 ttgctatttg cttgaatgta aatttccttc aaacgaggta ttagatcaat ttttaaatga 551881 cttaaataaa catgcaaact ataaagtgtc gattgttatt ggtaaatagt taactttata 551941 aaacggagat gtgcggtcat ataacatgat atatatgctc taaaaaagcc ctaggttgga 552001 tatggaattt accaagctgg ggccttttta tacattataa taacaagcgc attattcatc 552061 agacattaat gaagtattat aatgcttttt tacttcctta atagacaaat aaagctgata 552121 gtttccatac ttcaataaat cattcagaag gtgatttaaa acttcttgtg aatgaaccgt 552181 taccttcaga agataacatg catctcccga aacacgatga gcttcgctaa tttcattacg 552241 agtagcaata aatttcaata aatcatcatg catatatgca ttcatgaaaa agaagacaaa 552301 ggctgtaaaa gaaaacccca tcttcaattc atcaaccaca atcgaatatg ctttaatgat 552361 accgttatcc tccatttttt tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt 552421 ttcaccgatt tctttccatt gtatccgagc atttttattt aataattgga gaatttgaaa 552481 atcaattgaa tcaatttgca tagtaactcc tttcacagtg aaaaagtttt acaaaatagt 552541 atttcatgag accatcgaaa attcaatgga aattatatat ccttatacag tataaaaatt 552601 ttaagaggtg aaaaaatgac aacagcttta ttagtgattg atattcaaaa tgattacttt 552661 ccaaatggga agatggcttt aacaaaccca gagaaagcag cacaaaatgc ggctaaacta 552721 ctttcacact ttagaaacac aggcgcacct gtctttcatg tacagcatat cacagaaggt 552781 aacatcgctc attttttcca tccaaataca gaaggtgtcg aaattcatga gtcagtacgt 552841 ccattagaga aagagacagt cattgtaaaa catatgccga atagcttttt caatacagat 552901 ttaaatggaa agctacaaga agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc 552961 catatgtgta ttgatgcaac agttcgttct gcagttgaac atggttatgt atgccaagtg 553021 gtagaagatg cttgcgcaac aacaacattg caaattgaag ataaaatcgt tcctgctgag 553081 catgtccatt acgcatttat ggccgcatta aatggtgtct atgcaacagt aaaaaccaca 553141 gaggcatttt taaaataaaa gaatttcctg cgcgaacata acgtctttct tttcacaaga 553201 aagatgattc aacaacttaa aaaaggatgt tcagaaaaat acttctggac atcctttatt 553261 cattatcttt tattgttttt cagtatcatt attcccatct gataaaagat caagatgtcc 553321 tgtttttgat ccatagtaag accatataca gggattgttt ttgccataaa tatagatatt 553381 gatgaaggtt tacataaagc acctaattgc ttgatttact ttaatgttag atccctcaat 553441 aactccattc tcttctaatt tctctactct agctgtagct gctgggcatg ttaaatgtac 553501 tctctcccag atctttcatt gaattcggct attatacata atttctctat aattttttat 553561 ctgtttgatc tatttgaacg ttaattcctt tcgaaaataa agtcaaagag ttaaaacact 553621 tttttttatc tatgtattcg aacactgctg atattataca cttaactctg tcgatctaag 553681 acaaataaaa aaagaaagtg agttgtaaat atgaatatta cacaaattcg aaatgcaaca 553741 attgttgtaa aatacgcaaa taaaaaattt ttgatagatc ctatgttagc agagaaaggt 553801 acgtacgcta ctttccctga aacgatcaga caagatttat ttaatccttt ggtgagtttg 553861 ccaacatcaa ttgataacat tctggatggc gtagatgcgg taattgttac tcatctacac 553921 ctagatcact ttgatgatgt ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt 553981 caaaatgaag cagatgcaaa agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta 554041 catcaagaca ctgtttttga agggatccaa ttagtaaaaa caaaaggtga acatggcaga 554101 ggggaagagt tattaaactt aatgggtgat gtttgtggat tagtattcaa gcacccaagt 554161 gaaaaagttt tatatgtagc tggggataca gtttggtatg atgctatcga agacgagatt 554221 catacacatc aaccagaaat cattgtggtt aatggtggag acaatcaaag attagattta 554281 ggttcactca tcatgggaaa agaagacatc tatgaagttc acaaggctgc tcctcatgct 554341 aagattatat ctgttcatat ggaagctgtt aaccattgga cactatctag agaagaatta 554401 aaaaacttta gtaaagaaaa aggattctca agtaatattt tagtgccaga agatggcgag 554461 tcttacacat tttaatatga acaccgacaa ataaatagaa gaagctcata attataaaaa 554521 ctaatcatga gcttcttcta ataatgaata ttttaaattt taaatatatc gaaaatccta 554581 aatatacgga ataacaaaaa tggaatgttc caatgatgac aaaaaaactt gaaaagcaac 554641 aaagatgtgt cgttaggagg tagaattcat ggtaatgaca aaaaaagata caaatatatc 554701 aacacagcag cctctttggt tacaaggtta tattgattca ccagaaaaac aaaaccaact 554761 ttataaaaaa acattaaaaa tcttgatttt ttcacaaata tttgggggag caggacttgg 554821 agctgggata acagttgggg cgcttcttgc acaagatatg ataggatcgg aaaatgtagc 554881 aggaattcca actgccctct ttacttttgg atctgccgta gctgccctgc ttataggagc 554941 atcctcacaa cgttttggtc gcagagctgg acttgcaggt ggtttcctta taggcggatt 555001 aggtgctata ggtgtgataa tcgcggcttt aattaacagc gttgccctat tatttgtttc 555061 tcttcttatt tatggagcag gtatggcttc taatcttcaa gttcggtatg ctgggacaga 555121 ccttgcaaat gagaaacaac gggcaactgc tgcaagtatg gccttagttt ctactacttt 555181 aggagctgta gtaggtccta acttagttaa tacaatgggg gaatttgcag attcaattgg 555241 tgttcccaat ttagctggtc cgtttattat gtcaggagca gcttttataa ttgctggaat 555301 tattctctta atttttcttc gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc 555361 tgagaaaaaa gacgataaag tacaaatagg aggaagtcta aaaaatcctg ctatagacaa 555421 aaaaggaata atggtaggag ctgtcattat gattttagct caactaatca tgacagctat 555481 tatgacaatg acaccggttc acatgggtca tcacggtcat ggtttaagcg aagtgggatt 555541 agttatagga ctccatattg cagcgatgta tcttccttca ccattgactg gtttattagt 555601 agataagttt ggtcgcacaa ctatggctat tgcttcaggt gccacacttc ttgccgctgg 555661 gttggtggca gctattgcac cggcagactc attatcattg ctaatcctag cactagtatt 555721 actaggggta ggttggaact ttggtttact aacgggaact gcccttatta tagattcaac 555781 acatccatct ctacgtgcaa aaacacaggg aacattcgat gttttattag cactatcagg 555841 agcagcaggt ggagccttgt caggaatggt tgttgcacat tctagttata caatactatc 555901 aatttctgga gccgttttat cattgttact cattccagta gttatttggt attttagaag 555961 gattcaggaa aaagcataag cttatataac tgtctttgaa gaacctaagt agacattact 556021 ttaccggaac ctcctttttc tatttattat agtaaggagt tgacatggca ttagtggcat 556081 gtgtataact acacaattat ttgggattca gagagcatgt aatgaacgga agagataatt 556141 atttatcact tttattattg tacggtgttc ttgtggcatt aagttcagtc aattttggtc 556201 taactgtttt ctttttgttt tcatcacctc tccatattat taacaaacac gaaaaggatt 556261 ttaatgaaaa taaaatgatt agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc 556321 tttttaagat ttacacactt attctccaag gaaaaatgac tcaatttttc gattttttat 556381 gtaaatcaaa aaagaatcat gttagagtag gtgtgctgaa aataattcaa aaaattattt 556441 tgcgatatga ttaaagtaat attgccagag agtttcaatt ggacaaaatt gtaagtgttt 556501 aatacactgg ggctgcaatc aaatatgcac ctggaatcaa ttgctaaacg ggggagttta 556561 tatgaacaac aagaaaaata tctttgatat tgttatgtac attattttcg gtgtgttaag 556621 tctttttcta gttgcaaaaa ctgattatgg cactggagtt ttagtgtttg ttgcaatttt 556681 atacctcgct gttattgctt ataaaattaa gcaagtattt agtaattcag attcttaagg 556741 tgtaacacaa ggaggatttc aattgagaaa gaaaagagtt attacttgtg ttatggctgc 556801 atcattgact ttaggctcac ttttacctgc aggttacgct tctgcaaagg aggactctaa 556861 gacaacccct tcttacgaag aactagctct acattacaaa atgaaaagtg aaaagatttc 556921 atcgaacggg aaattagttg aaattgagta tgtgagtgga aatgaaactc acaaagttca 556981 gatgaacgga aataatcata ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt 557041 tgagtatgat gaaaatgttg ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa 557101 tgaattcaca acacaggctg caaaacctaa aaagggatac cattatgtgg ggactttatc 557161 tgggcataca aaagcagcta aaaatgcgtt atcagttaca atgtcattag tcggtattgt 557221 ccctggcttg ggatggggga gtaaggctgc cactatttta ttctcttatt gggcaaaaga 557281 acaaatccct gatgcgtatt ataaatatga tttatacgaa aaaggagcaa tgactgatag 557341 ttggtatcag tatgctacag ttcaattttt tgaagataaa gctcataaaa agaaaatggg 557401 caaaccttgg acaagtactc ctgcaaaagt agatttacct aatagctaat tttaaaatca 557461 ctttgtcttt ataaaggaca aagtgatttt ttgttataca gaagtaaaat ccctcgtctg 557521 aggaatcttg gaaaaaactt ggttcaattt tgatataaca tgtttttttc ttgctaattt 557581 agtttttcta tgtatcgcta cacattctaa ataataagat attagccgga cggttgatgc 557641 caagctcaaa agtttatatg gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct 557701 tctttttatt ttgccaacgt aacaagtgtg aaagtaatga tttgtaggat cagttaagaa 557761 aggtttaaga ttagatattg aaaaatttta tatattttca ataaaatact ggtactataa 557821 taaatgtata cagattgtat ggagatgtaa ttaattaaaa aggagttttt aattgcgttg 557881 gagtaaatgg ttcaatgttt tttgtatagt agcattggga tcaatatatg gttataaatt 557941 atttactaac caagaagtca gtactactcg tttaataata gcttctgtaa ttgtgttgtg 558001 gaatattgtt ggacttttta gcaaagaatc agtaaaacaa gcacagcaag caaattaaaa 558061 gtcataaagt tgggaaagaa ggatgttact tatgtagtat ccttctttat tattccttga 558121 aaaatgaaac aaattggaga ttacagctta tataatcaat tgaagtcgtt gattattttc 558181 atgaacagga gatttaatgc tttctgatga aatattatcg tatgaatgtt gcaagaggaa 558241 acgttactca aagattacag ggatgtgatg aacactcctc tttatcgcac tcacctgacc 558301 ccaaattgtt ggggaagggc aggtacggaa gatagagtat tttttcttcg taacaaatcg 558361 aaaaggttgg ataataaaaa acttataatc taaggcggta tatagttgtg aaaaaggcgt 558421 tatttcttat attagaccag tatgcagatt gggaaggtgt ttacttagca tctgcattaa 558481 atcaaagaga agattggtcg gttcacactg tttctttaga ccctattgta agctcaatag 558541 gtggttttaa aacatctgtc gattacataa tagggttaga acctgcaaat tttaatttgc 558601 tagttatgat tggcggggat tcctggagta atgacaataa aaaactatta cattttgtaa 558661 aaactgcatt tcaaaaaaac attccaatag cagcgatatg cggtgcagtg gattttttgg 558721 cgaagaatgg tttgctgaat aatcatagcc atacaggtaa ttttgtttac ttatggaaag 558781 attacaaaca atataaaccg attagcagtt ttgtagagaa acaagcagta agagataaaa 558841 atttggttac tgctaatgga actgccccta ttgaatttac taatttaatt ttagagatga 558901 ttgattttga tactcctgag aacatagaga aaatgatgta tatgaatcgt tatggttttt 558961 atcatttttg tgataaatat ggaaatccat ttgttgatta atttgctgga aatgattttc 559021 ccgaataggg ggctttgcga ttgagttgaa tttcctaata aagcaaagaa agatgatttg 559081 aggtcaagtt taacaaataa tgccatcaat attaatttgc agttatttcc gattcctgat 559141 ataataaaga agaattattt ttgttcggtg taaaggatag tatgaagatt gacttttcgt 559201 cttgatgata ctttgggcaa ggatagtata tactgtgtgg ttacacacta ggaggcaaca 559261 aaaatggaac aaggtacagt taaatggttt aatgcagaaa aaggttttgg ctttatcgaa 559321 cgcgaaaatg gagacgatgt attcgtacac ttttctgcaa tccaaagtga cggattcaaa 559381 tctttagacg aaggtcaaaa agtatcgttt gacgttgagc aaggtgctcg tggagctcaa 559441 gctgctaacg ttcaaaaagc ttaatcttca atcgtttata caaacaggct ctttatatag 559501 ggcctgtttt tttatgtcta tatcatactc aataaaaaac cctactcaac gttcgagtag 559561 ggagatgcta caaggtaata gaaaaagatt taaaacttca aaggtttgtt tacagtataa 559621 catactggat tgacaatatg cggaatgtat ataaattatt taatgttttg ttcaaatata 559681 gataactgac tctttttttc actaacctgt tcgttcattt aagtaagatt agatgaatta 559741 taaaaatggt ttcatctaaa tgttatcaac tcgcatatct cttttatgag aagaagataa 559801 acaattatta ttcaatgttg cagtggatat aagaaattct taaaaataat gaggagatcg 559861 attgtttttt tctcctggaa ataatcactt agagatacct aaaacaatga aagccctacc 559921 tctcttccat ccttacggct ccttgtccgt gccagtgtga atcaggatac taaaaaaagt 559981 gactatttta ttgagttttt tggtaaaact tcaatcttcg cagaagaaat gtaaataata 560041 aaaatggatt agaatgtagg aataacaaaa gaggtcgtta atgttctaaa cataagttgg 560101 agaagatttg cttttcatca taatattccg aaatatcttt tgggatgtat ctaaccaaaa 560161 ctttttattt gtttttcagt gattccttta attacttcca gttcactaat caaaaattca 560221 tatgcattat ccagcatttt tttttcgctt gcattaagtg ctttttcttt cttcatacgc 560281 attaaatcac gtacaacttc agcaccttct tgtatttcac ctgtttttat tttgtccgtg 560341 tttattttgt acctttgctt ccatggcagt aacctatcgg attctccatg ctgaaaaatg 560401 tgcataatgt gttttaatgc aagtatatcg gtaactggtc gtatattcga actcaatatt 560461 ttactcgttg gaatcataac tgtcatatta ctgattgaca ttcttatgac ataatactgt 560521 tgtttttcct ctaagaattc tttttcttct atggcttcaa ttatacctgc tccgtgcatt 560581 ggataaacaa tgttatcgcc aatttgaaac atatcatcca cctccatata tggtatcctt 560641 cttaagatta ccatatatgg aggtgtaata tcaaaatttt aataataaca tgatcgaatt 560701 tttgatgtca ataacttttt tgaaaaaaca gatcaagcaa aaacaatagg gaacgtgtcg 560761 gatttccaat caggaaaagg tcaattgatc cgtgtgagca gtttttcatt ggctcaatga 560821 cattacagaa atgatttgag tagataagaa agaacgatat tcgtgaaatg tcagctaaaa 560881 atatttaaag cacatgatta agttctaatt tctttaccga tttgatatgg ataacggccg 560941 acttacttaa tgatgcattt tcacttatct tgcaagcaga aaaaggtttg ttgataaaca 561001 tttagccacc aaattggcat tattatcagg gaaattgaca accttcaaat gggtattgag 561061 gcgagaagaa aaataaagaa aggagagatt ataaatgaag accagaacat aaagaagtaa 561121 aggggaaaga acaaggttaa ttgaaaagca aactatataa aatagtttgc ttttttttgt 561181 tatgacttca cttctttttc tttctcttta atgactaata aaacaccgct cagaattaaa 561241 aacgaaccta tccaaaatgt cccgcctatt tgttctccaa gcagaatcca tccgagtaag 561301 gttccaacca gaggctgaaa aaagaaaaag aggcctccac ttgaggcatt taataattgt 561361 aagccgtggt tccacaataa aaatgcacaa gctgttgaaa caattcccaa atacaaaagg 561421 ccacctagaa ttttagggtc aagcagtagt ggcgtaaaaa tcgtgctagg ggagtaccat 561481 taacagggac tccatttatt aatagaataa actttatgaa ttcatttttt tgtatgataa 561541 tggcgtcata ttcatcgctt gttgaaattt acttatgaaa taactggtac tgttaaatcc 561601 aacttgataa gacacttctg tcacattgga ttcagggtgt tgcagtaata ataagctttt 561661 ttgaattcta taatccatta cataacgtaa tggcgtctta ttcagcattc gtttaaaata 561721 acggcagcat tcagaacggc tcagttggcc agcttttgca atgtcctcta atgtgatttt 561781 ttcaacataa tggagatgga tccagtttaa catttgtttc attcgatgac tttttatcat 561841 ttcagattga tcgtactcta attgaaaacc attaacgacc aggtttttcc acattaacgt 561901 taattgcatc gtaatgtcaa tctcatagag cgatgtcttt tgttgaatca attgatttat 561961 ttttttaaca gcatctagaa tattttttgc ccactgttga tttccagcca aaaataaata 562021 gggcaaattg gttgaaaaca tatagggctg aacatagctt gaatacagtt cctgagataa 562081 aacgaaatgg ggtgacacat tcaagcaaat atacgtacaa tccgagcctt ccttttcttc 562141 ggccatgtgc aggtagccgc tattgataaa taatccatcc ccttcgtgaa cctctatttt 562201 ttcttcattt atttgaaaga gagctatccc ttttagtatc aaaacaaatt ggatttcatc 562261 atgccaatga agcggaatat agccatttat attttgattg atcgttgtct tgtagcaggc 562321 aactggcaat tctaccgttc ggtgctctgt taattctttt aaattttgat cgatcacaaa 562381 attcttcatt ctgacttcac acctcaatat atttatattt tttcattcaa tttgagtatt 562441 ttttatcatg ttttgcattt attataacac tattattata tttattagtg aggagtcatg 562501 tatgaatact tccaatagaa gaatgggatt gttctatgtt atcacagggg cgacatgttg 562561 ggggattgga ggcacagtag ccaaaaaact ttttcaagaa tatcaaattg atgtcaattg 562621 gcttgtaacg acacgcttgc ttacggctgg aatgttactt ttaatgctgc aactgttcag 562681 aaaggatcgt tcccaggtta ttgaggtgtg gaaacacaaa gcgtcggctg gccagcttct 562741 aatttttggc ctattgggaa tgctagctgt gcagtacaca tatatggcat ccattcaaca 562801 tgggaatgct gccgttgcta cgttattgca atatttatcc ccagtaatcg tcattatcta 562861 cacgctgttg cgaaaacaaa cggttcttac caaacaagat atcataactg ttgtacttgc 562921 tttagtgggt tgcttttttt tgttaacaaa tggttcaatg tctcaacttt cagtgccggc 562981 agctgcagta gtatggggag ttttatcagg attcgcggca gctttttata ctttgtatgc 563041 cgttggttta ttaaataaat ttgattctct tgtcgttgta ggttgggcta tgattattgg 563101 cggttttgca ttgggtttta tccatccgcc atggcaactg gattttcaac gattaactgc 563161 tgaggcgtat gcatatatct tattcgtgat attatttgga acaatgattg cgttctggtt 563221 cttcataaaa agcttggaaa gcctctctcc aaaagaaaca agcctactag gcagtctaga 563281 gcctctatca gctgttgtaa caactgtcgt ttggttaaaa gcgccatttg gttcttttca 563341 atggattggt gctatttgta ttatagggat aactttaata ttggctttac ataaagagcc 563401 ttctatggag agtgaaaaat cgatattaaa gattaggaat catgcaaatc gggatatata 563461 ggggcttttt ttgcttacat gaccggtccg gcaatgaaaa acactggtgg agtttgagcc 563521 ctctcggcag tatcaaaaat accaagggtt ttgacgccct aggtattttt tcttcaagaa 563581 ccttcaattt ttcttctctg attgaaaaac gtattacttt tttgtgattg gtatccaaat 563641 ttcactttta aaagatggtg atgttacatc cttatgctcg ttccacaata tttctggacc 563701 ttctatttgt tcgtaatttg acgatggaaa ccattcggaa taaatgcgtc cccatacttc 563761 ttgcagtgta tccggaaatg gcccgattga ttcgaataca gcccatgttg aggcaggaac 563821 ttcaagccgt gagaagttat ctggacaccg tttcgttgtg gctgcgccaa tatagtgatc 563881 gagctctccg ttttcctctg tccgaccttc agaaaaattc gtggatgcac taatgaggcc 563941 tgatggtgct acattagata gctcttttag tttatttatt gctttttcat ctaaactttc 564001 ccacatagat gcaatttccg gattaattcc tttgaaaata ataggaactc tttttttaat 564061 gccaacgatg cgaaatgcct ctttttcttc aatacggtag ttcatttcat ttcctccttt 564121 aattgttagc tggaaggtca ttcgtggata agctttaagg gaatggccat taaatctggc 564181 ttttgatggg tttatgccat gtaaattttg gaatgcccgt gcaaaagaat ctggtgagtt 564241 ataaccgtac tttattgcaa tatcaatcac ttttacattg ctgtctttca gttcaaaagc 564301 tgcaagagta agacgtctgc gacgaatata ttccgataat gaaatacctg caaggaagga 564361 aaacatcctt ttaaaatgat attcagagca gaaagcaagc tttgctgcct cttgaaaatc 564421 aatatcatta gtgaggtttt cttcaatata ctttaacgcc ctattcatac ttttaagcaa 564481 atccatttat ttggcctcct ttaaccaaag aataacagga gtgaaatgta tttatccgac 564541 attctgtgca cagttttgca ggatgactta tatgaaataa agtaagtgat tcacttgtat 564601 ttgtacaggt tttattgaag catgctgttc ataaaaaggc atcaataaaa gaaagttata 564661 attgtcttat aaacggcaca ttcatataat tgagtgaaaa aggatgcgta tcatgcctat 564721 caattctttt gaaaattatc cgatgagctg gaagccatcg attgataaag ctgaaaagcc 564781 tatttataaa gcacttgcag ggcaattgga acaggatatt ttaaacggag ttttattacc 564841 tggaacaaaa cttcctccac agcgagaatt ggccgattat ctagatttaa atgtgagtac 564901 gatttcaaaa gcatttaaag tgtgtgagtt aaaagggctg ctgagtgcga ctgtagggag 564961 cggcacattt gtatcgtatg atgcgttgtc gaatgcgtat ttacttgagg atactaagcc 565021 gacacattta attgaaatgg gagcaatact tccagatcac gcttcatatg agcccttgtt 565081 ataccaactg aaaaacatgg ttcatgagga ggattatgaa aaatggttta gctatggccg 565141 ggcaggtgaa agcctttggc aaaaagatgc agctgtaaag ctcatccaaa gaggcggatt 565201 tgaaacatcc gttgatcaca ttttatttgc aaatggaggg caaaatgcga ttgcagcgac 565261 attggcgagt ctttgtaagc ctggagatcg catcggagtt gaccatcata cgtaccctgg 565321 attaaaaact gttgcatcat tgcttagtgt gcaaatcgta ccgataaaat cagaaaacga 565381 tgaaatgagt ccggagtcac ttgaatatgc gtgtaaaaac gaaaatatta aaggtttgta 565441 tttaatcccg gattatcata atccgacgac ttcctttatg tctgttgaga atcgaagaat 565501 ggttgcagac attgtaaaga aatataatct gtttgttatt gaggatgcat cgtaccatct 565561 tctcaacaaa aatccgcttc cggcactcgc ctcattcgca ccgcaacagg ttattcatat 565621 tgcaagttta tcaaaatcgt tagcgccagg cctgcgtttg gcttatgtag cagtgccgag 565681 acaatataag gagccaatat caaaggcgct ttataattta aatataactg tttccccgct 565741 attagctgaa cttactgctc gcacgattgt atcaaatcaa tttgaagtct taattgagag 565801 tcatcgtgaa caaaccattc gcagaaatca actcgtaaac cgatatgttg cgggatatac 565861 atgtttaggt gttgaaacag gcatttttcg ttggttgttg ttaccgggta aaatgtctgg 565921 tgccgaattt gaagaattgg ctgctcgact tggcgtgcaa gtgtatgcgg ctgaacgctt 565981 tgtagtggga aatagttgtc ctgaaagggc tgtaagggtt tctgtctgtg caccaaaaac 566041 acttgaagag cttgaacaag gattaatgat cctgagacgt ttgctagacg atcttaccta 566101 atattgtttg ccatacaatt atgacattgt atggcttttt tgtgcgtgtt atgatgatcc 566161 acatctagag ggaggtttat acaaaattgg cttttagaaa ggaaggtcag atgatgttag 566221 acaaggacag cgtaaaagca atagatgttc aaactgcttc attacagagc tacatcagtt 566281 caccagaaaa acaaaaatcg ttatacaagc gtacactatt cgttgtgagt atctcacaaa 566341 tttttggcgg tgcggggctg gcggcaggag tgactgtcgg tgcgcttatt gcacagcaaa 566401 tgcttggcac tgatgcgttt gctggtttgc cttctgcttt atttacttta gggtcagcag 566461 gatctgcatt aattgttgga agactttctc aacgttatgg ccgtcgaaca ggtctttcag 566521 ctggctttat gattggcgga cttggagcaa taggcgttat tatggcagca atcataaata 566581 gtattttctt gttatttatt tcgttgctta tttacggtgc aggtacagcc actaatttac 566641 aggcccgtta tgcaggtaca gacttagcaa atcataagca gcgagcgact gctgttagta 566701 taaccatggt ttttactaca tttggcgcag tggcaggtcc aagcttagtg aatgtgatgg 566761 gggatttcgc tctttctatt ggtgttccat cacttgctgg ccctttcatt ttagccgcag 566821 cagcatatat gttagcaggt gtggtccttt tcattatgct tcgtccagat ccattagtta 566881 tagcaagaac aatagaagcg gcaaatgaag agcctggtga taaaggacat ttggcggcaa 566941 ctgagcatac agaaaacaaa aaagggataa tcgttggggc aacggttatg gttcttaccc 567001 aaatagtaat ggtagctatt atgacaatga caccggttca tatgagacat catgggcatg 567061 acttgggtgc agtcggtctt gttattggtt ttcatatagg tgctatgtat ctcccttcac 567121 ttgttacagg tgttcttgta gataggttgg gacgtaccgc aatggctatt tcctctggaa 567181 caacgttgct tttggcaggt gtaatagcag catttgctcc gggagaatct atgattcttc 567241 tcgtcattgc tctttcttta ctgggattag ggtggaattt tggtttgata agcgggactg 567301 cccttattgt agattcaact gatactgcca cacgagctaa aacgcagggg acagtggatg 567361 ttctgattgc gttgtcagga gctgctggcg gagcattatc tggaatgatt gtggcaggtt 567421 caagttacct cgcattatca cttattggag ggattttgtc cttattactc attccggtgg 567481 tggtatggtc taggggccgc taaagggtag gattgtttaa tttacattaa tttgttatat 567541 tgttagataa agtatattgc agcatctaat attctaacga actatagttg ctccattaaa 567601 tctattataa agatttgacc aggattcctt atagctgtgt cactcactgc atattcttta 567661 attgaatcac ataaaatggt tatcggattt gaaaaaggca ggattactcg ctttaggtaa 567721 aggagtcata acgttgttaa aaaggttttc tcttgttatt gttacactaa tgatgtctat 567781 cgttgttgtt ttagcggctg ctaaagagtc gcctggagat catgtcatct catttgatga 567841 acctattatc ttgatgatct caattggaat cgttgtattt ttattgatcc ctccattagt 567901 catgtccttt tttggcaatt tggttgtaag aataatatct ggtgtatacc aatgttttat 567961 cgttttcact tttctggggc tcattccaat tggatttctt attcccaatg gctttttgac 568021 aattctagtt tctattgcag gaactttagt cagtatagct agtgttgccg taaccttatg 568081 cattggcaag aataaaaaag atatataatc atcgaattgt tattttttca gattgtcagt 568141 gaaataatta tacaaaaaga gaaggcttgt gggccttctt tttttgttgt tgcatcatcc 568201 ccactttgag cttaatctat tgaataataa gagaaggaac ctatagaaga ataaaataaa 568261 taccgagatg tcaaaaataa aactggactt cattattgtg aattcacgta aatgtaaaaa 568321 gattggaaag aggggaattc cttcatgaca aatagcagaa caaatccgaa ggttgatgaa 568381 tttttaagta aagcgaaaaa gtggaaggaa gaatttgaga agttgagaac catcattctt 568441 gactgtgagc tgactgaaga ttttaagtgg atgcatcctt gttacacata tcataataaa 568501 aatattgttt taatacatgg gtttaaagaa tattgcgcgc ttctgttcca caaaggcgtc 568561 ttattacagg atacagatgg aattctcatt caacaaacgg agaatgtaca ggcggcgcgc 568621 cagattcggt ttacaaatgt tcaggaaata aatgagctag aaaacatttt gaaagcctat 568681 attcacgaag ccattgaagt tgaaaaagcc ggtttgaaag tggatgttaa caaaaatatt 568741 gaattgaaca ttcctgaaga acttcaaaat aaattcgatg aaatccctgc attgaaaatt 568801 gcttttgaag ctttgacccc gggacggcaa agagcgtaca ctctttattt ttctcaagcc 568861 aaacaatcca aaacccgaga atcgagagtc gaaaaatatg tgcaaaaaat tctcgatgga 568921 aagggattaa aggattaggc acgccaaggt tcaggctaaa ggaatagcat catagcgtaa 568981 taagatcatt tctatagaag aaaaacaagc atagtaagat gcttgttttt tcttaggaca 569041 acattcactt actgctgaaa tgcttctaac attgtatgcc actagacagc gttataaaat 569101 attaatgcaa cacctagaaa tctatccaat gaaatagctc aatggtatgg ctcattacat 569161 ttagaatgcc taggagaact aatagaaccg gaagattttt agcaagttac tacactccaa 569221 actttgtttt tgtattaata taccttatta accattgttt ttagtcaggt gcagacaaac 569281 gaatactgat taatgaatca tcatgatatc aatgagccgc ttgatttttt catcgtcgcc 569341 tgtatcaacg tacactgttt ttctgttttt tatgatactc tcagtcactt cccgcatgac 569401 gcctttttct atatcatcag cggaatccca gcgtaaaggc acattatata catgaattgt 569461 gccatcccca ttgccatgat aagtgactga tccatccact aaacgagaac ctgccaactg 569521 ggtcacattt tctggatagc tggcacttgt atcatcatta ggattaattg gctcgccagc 569581 cgcaatatgt cgaacattta attcatctat ctcttgatta ggtccaagtt gaagccaaac 569641 tctggcatat tcaatttttt ccgaagagta tgctgccaat acattgtctt ctttgctttt 569701 ctcttctgct gaagaggtat catttgcagc ttttgttgcg gattcttctg attctgttat 569761 tggctccgct tcatccttgc gtattttggt gctctcttca ggctcagtgt gtttttcgtc 569821 agtttgcaca gcagaagctt gatttgaagg ttgttgtgct tctccatcct tactgtccgt 569881 acatccagca agcaaaatca taagcagcag ggcagtattg caataacata tctttctgcg 569941 tttcttcatt ttttcattcc tctctattaa ttcaggtcag cttcatatat aagtttatgt 570001 atctaaatat taccatggaa tagataggat gatattgaaa actgtttaag aagaggaaac 570061 gatcttgaat agcatcgcga aaacctaaga atcttaagaa gttttgcccc tttttcttca 570121 ggtattgaat gtaaagtggg atataaatgc aaacaaaaac gaaatgcctt atccacctcg 570181 tgtcatggca gaaaaagtgg gggatttatt agagcggatt tgataatggc ggcaggtaaa 570241 tgggtgttga cttatatgtc taagcgggag actcaagtct gctcgatcgc atacaaaata 570301 ccaagggcca gcaacccttg gtatttttat accttcatgc atttttgaag tttatgctta 570361 aaggtctgcc ttactttgca aatcgccgag ctgctgcaac gcacatgata acggcgatat 570421 tcactgctac gagtgcccag cccactttct cgtgcagaat cactgaggca agcagcagtc 570481 caaaaaaagg ctggagaagc tggagctgcc caaccgctgc aattccccct tgggcaagac 570541 ctcgatacca gaacacgaag ccaatcagca tgctgaataa ggatacatat gcaagactga 570601 gcagtgcggg aacgccgatc gccgaccatg agtccggcgt aaaaaagaac gacaatggca 570661 gcataagagg aagcgacaga acgagtgccc atgagatcac ctgccaattc cccagacgcc 570721 gtgaaagttt ggccccttct gcataaccaa gaccgcatac gacaatagaa gccagcatgt 570781 acgcgtcgcc aagcggggat gaacctcccc cctgaatgag ggcgaaacct gctactaaca 570841 agctgccggc agctgagaaa atccagaaga cggggcgagg gcgttcaccc ccgcgcagta 570901 cgccgaagac tgccgttgcg agtggaagaa gtccaatgaa gacaatggcg tgtgcggatg 570961 tgacatgctg aagcgctaaa gctgtcagca acgggaaacc aatcactacg ccgaacgcta 571021 ccactaacaa tgaaatgaga tctcttttgg caggatgctg ctgccggaag atgagaagga 571081 gacctcccgc cagtacacca gctatcgcag cacggcaaac tgtgagaaat aacggatcga 571141 agtctgacac agccaaacgg gtcgcaggca gcgagccgct gaaaatgagt acgcctataa 571201 aaccatttat ccagccattt gttgttttgt tcattataat cactccacat atctttcttg 571261 ttcattgtct gtattttctt aacaaaacca gcagctaagg attacaatga ctataaactg 571321 gaattggcct tttataaaca gccagttttc ataaaaaaat gcataccagt taggagaaca 571381 acgcgcaaat ggatatcacg ccttttttga atagaactct ggatattccg ctttatcagc 571441 agctttatcg gtattttaaa gaaaatatgc atcggggccg tattcaaaaa ggaatgaagc 571501 ttccttcaaa aagactcctg gcgaatcagc tttccatcag ccaaacgact gtagaacgtg 571561 cctatgaaca gctcgctgct gaaggttata ttgtgagcaa gccaagaagc gggtggtttg 571621 ctgattatca tgattctgat tttgcttatg atagaatgcc aagcacaaca cccattcaac 571681 aagaagcaga agaaaataaa caatggattg attttcatta tgggaatgta gattcttctt 571741 acttcccttt ttccgcatgg cgaaaaagca tggtcaatag cttagaccaa tatggacacg 571801 agctttatcg gccgggacat gttttaggag agtttgagct gagaacactc attgcagagt 571861 acctgtatca atctcggggg gttcattgcg gccctgaaca agtgattata ggtgccggga 571921 accctattct gctgcaaatc ttgtgccaag tttttgagcc gaatatttct atagggtatg 571981 aggatcctgg ttatccaaga gcacgcaaga tttttgaagc caaccgcatg aatattgttc 572041 ctataccagt cgatgatgag ggaatctgta tacagaagat caaagaacag cagccaaacc 572101 ttgtatatgt cacaccttcc catcaattta cgctgggaac cataatgaca ataaacagaa 572161 gaattcagct gctcaaatgg gcggccgaaa atcaatcctt tatcatagag gatgattatg 572221 acggggaatt taggtacaca ggacagccgg ttccttctct gcaagggctt gatcagcata 572281 accgtgtcat ttatatgggc actttttcta agtctctttt gccctcgctg cgtatcagct 572341 atatgattct tccttcgcct cttttaaaaa agggtcatga aatcacgtcc ttatataagc 572401 agacagtgtc ctgccacagt cagctaaccc tagctgaatt tataaaaaat ggagagtggc 572461 aaaaacacat caacagaatg agaaaacttt accgcaaaaa aagagccatt gtattagagg 572521 cagtgcaaag ggaattagga gagcatgtca gaatccgcgg agaaaactct gggcttcgta 572581 tcttacttga cgtttatttg ccatttggtg aaaaagagtt aattgagaag gcgaaaaaac 572641 atggagtaaa aatttatcct gtttctcttt cttatcaaca tcatcctcct acaaaaacgg 572701 tctcgctcgg gtttgcaggg gtttctgaat ccgacataag agaaggcata aaaaaactga 572761 aggctgcctg gaagatatga gggagctttc agtttagcaa aacggccaag tgacgactaa 572821 gtgttgagag ctgttcaata ttttttaagt atatgatgag tgcctgcagt ccaggccacg 572881 atacgtctgt ttagcgaaaa acagaatttt ttatttgctc ctcacagtgc taaaataaac 572941 aaaatagaca attgaaaaaa tagaggtgta agaatgaagt tagatgagtt tacaattggc 573001 caggtcttca aaacgaaatc attaaaagta tcaaaagatg atattatgcg gtttgcgggt 573061 gaatttgacc ctcagtatat gcatgtagat gaagaaaaag cgagtaaagg cagatttaat 573121 ggaattatcg cttccggcat acaaacactg gccatatctt ttaaactttg gattgaagaa 573181 ggtttctatg gagacgatat tatagccgga acagagatga atcatatgac attcataaaa 573241 cccgtatatc cggatgatga attgtttaca attgttgagg ttcttgataa gcagccaaag 573301 agaaatgaat tgggaatact cacagtattg ctatctactt ataatcaaaa agaagtaaaa 573361 gtgtttgaag gtgagttatc tgtattgatc aaacgataac tcagaaagcc cgcttttcgc 573421 gggctcgatt gaagcagatg ggtgaaagat gttagcgggt ttcctttgaa aaataagagg 573481 ttaaaacatc ataaacaata ggcaaagaag taaatccctc atcttctaga aaatgacctc 573541 cgtgctgaac ttcatataac gcagcatcaa tttgttgtgc cagatccttg ctgaatgaaa 573601 aaggcacaat ttggtcgtcc ttagaagcaa tgacagcacg gtgcttcgcg gactcgatga 573661 ttttttgatg atcaaacgat ccctgtgtaa attcatctaa catctgtaaa gtgggcaatg 573721 atttggcaaa gccggaaaca agtatgattc cgccaagctg ttttcgtaat tgaagatgtt 573781 ccaaaaatct caaaatggcg gggcaaccta agctgtgcgc aaccaaatac gtattttcat 573841 gtaaagtgtg ctgatataaa gagagtgtat ccagccaatc ctcaagtctt ggctggagcg 573901 gattaggcat gtttaaaatg tctgcttgga ccccatctgc gagcagacgt tttttcagcc 573961 aagggaacca atgatttgtt gaggaggctc tgtagccatg aatgatatag acttgttttg 574021 tcattatttc ctcctaagaa atattttcat tcagtataaa attcctctca ttgggaaaca 574081 agtacgcact tttttgtaag tagctttaca tatgaggccc tccttgtgcc attccccact 574141 tacacatctc atctatgagg ggatacaaag atcgccctct gtcagataac gaatactcta 574201 ctttcagtgg ggtgtgagaa acctcagacc gatgaataag gccgtcagtt tgcaattcct 574261 taagctgtgc gcttaacatt ttatgggtga tgaagggcat agcccttttc agctcgccgt 574321 atctcatcgt tttttcacac cctaactcat agagaattct cattttccat ttgcccccta 574381 taagagataa ggtgtattca aatggggctt gtttactgcg gcacaggcta ttcattgtaa 574441 tcaaacctcc ttttttaagt atcatatcag aataaattag gattttcggt gttgaagttt 574501 gagggcgatt cacgatctga agtgaaaggg gccgcttgct caacaggcgg cacggtacat 574561 gaatgttcta agtcaaagag ggttacctta ctgttagtta ctttatttaa aaaaacgcat 574621 gtttttagct gaaaatatct attatggtat atttaaatat aaagaaatat ttgagaaatg 574681 aggaatggta tgaatacacc caaaaaacat aagaaattta aagcgaaaat gattctccaa 574741 atcatcatgg ttatcattgg aggaatcata gcggcatatg gactagaaac agtgctcatt 574801 ccaaacagtg tatctgatgg aggggtgacg ggtcttagca tcgttggttc acagctattc 574861 aacttgccgc tggggatttt gattgctgtg atcaacattc catttgtctg gttaggatat 574921 aagcaaattg ggaaaagctt tgcattatta tcaattatcg gaatcgtatc gcttgccgcg 574981 gggacaagct ttttccacca cacacccgct atcatagaag gagataccct gttaattacc 575041 gttgtcggcg ggattatcct tggattcgga atggggctgg cgctgcgtaa tggcggcgca 575101 ttagatggaa ttgacatgct tgctgtgctg ctatcccgaa aactgccatt cggaacgagc 575161 gatctcattc tattcttaaa cctatttgtg tttatttttg tttccacagt atttggctta 575221 caaggggcat tgctttcagt cattgcttac tacattgcat ccaaagtgat tcatgttgtg 575281 gaggaaggct taagcggctc taaaaccttt caaattatta caacccaacc tgaattaatg 575341 gtagagacaa tacgtgatca attaggccga agcgccacat ataaagaagc ttacgggggt 575401 ttttcccacg agaaatttaa agaaatcaca tgtgtcatca accgtttaga agaaaccaaa 575461 ctaaaggaaa ttattaatga tattgataaa actgcctttg ttaccgtgta tgatgtagct 575521 gaagtgaagg gcagcaattt tagaaatctt aatcatcact aaaaaataga atgacctttt 575581 taaccgtaac tgacatgccg cgggtaattt aatcaaaaac acttttttga ggcttgtggg 575641 tgaataaccg gtgaaggtct gaatcacaga aataccaagg gcgtcaaaac ccttggtatt 575701 ttttctggtt attagatttt atcttcagct ttacgtgctg cttcgagctt atcaatcctg 575761 tctttatatt tttctcccca gtccttcatg tgcaggataa caggttctaa tgttcttcca 575821 aactcagtta aagagtattc gacttttgga gggacctgtt tataaacctc gcggtgaatc 575881 acgccatccc gttccaattc tcttaattgt agcgtgagca tacgctgggt aatttttggg 575941 tatagttttc gaaactcatt aaacctcttt ttaccgtcaa tgagatgata aagaagaatg 576001 cctttccact tacctccgat gatatctaat gttgtctcca ccggacatcc ttcaaagtca 576061 tcagaagaat aatcaatgcc gagtttacga tttctcaagc tgttcactcc taatagtata 576121 ctttttgata ctatatacat tcaatgtgcg tactttttat attttaatat acatcatata 576181 atgatgtcac atctaaggaa tgaaaggaat ggatcatatg aaaacactcg tactcgttgt 576241 acatccgaat atagaatcct ctcgtatcaa taaaaagtgg aaagaagccg ttttaagtga 576301 accagatgta actgtccatg atctttatga aaaatatcgc gatcaaccaa ttgatgtgga 576361 atttgaacaa cagcagctcc tggcccatga ccgtatcgtt tttcagtttc cattatactg 576421 gtacagcagc ccaccgcttt taaaacagtg gtttgatgaa gtgtttacgt ttggctgggc 576481 tcatggtccc ggcggaaata aattgaaggg gaaagagtgg gtaactgcca tgtccatcgg 576541 ttcacctgaa cactcttatc aagccggcgg atataacttg ttttcgataa gcgagctgac 576601 aaaaccgttc caagcatctg cccatttagt aggcatgacc tatctgcctt cctttgccga 576661 atatcgcgcc aatacaatca gtgaccaaga aattgccgaa agtgcgaatc ggtatgtaaa 576721 gcatattaca aatatagaat taaacccgaa ggttcgcctg caaaggtatt tgaaacagct 576781 ggagagtgtc gatttaacat aaagattgat ttttgaaaat cctgtactca ccaagcagga 576841 ttttttcttg ttcagcagag ggattttaac atatagcaaa aaaagaagaa gccaccaaaa 576901 ataagctatt tgcttggtcc tgactgctta tttttggtga aatacttatt tctctgtgat 576961 gaaataaagc aaagcgatga ccggaaaagc gattccaatc cataatgctg tactccatcc 577021 gcctgaggca tatgcccatc ctccaattga tgaccctatc gcaccgccta gaaagaagat 577081 cgccatgaat aatccgttta atcgactgcg aatttcaggc gccaacgaaa aaatagcacg 577141 ttgactgagc acaaggtttg cagatacacc catatctaac agaatagcag cggccactag 577201 aactgttata ccgacggggg agctgctctg aatcatgagc ggcagtaata aagagacaac 577261 gacaacaccg agagcgattc cagtggcaag cctggttaag cctcgatcag ccaggcggcc 577321 gcctattggt gcagtgactg cacccgcaat gcccaccaat gcgtagagtg ctattgcctt 577381 ctgagaaaaa tgaaaatcag gaccggacaa taataaagga acagttgtcc agaacaagct 577441 gaaagctcca aatacaaacg catgatagat ggcacggcgg cgtaagactg gagtcgtgcg 577501 cagcagcttc cacattgaac cgagtaaggc agtatagttt gtatttgctg ttggttttct 577561 ggcaggaagc acttttgata atacgatggc caggataaca cttaccacgg cggacaaagc 577621 gaatattgca ttccaccccc agatatcagc gactagacta gatatcggac gggaaagcat 577681 aataccgagt aataagccgc tcatgacatt gccaacaacc cggccgcgtg cagcgtctga 577741 tgcaaggtat gatgcaaatg gaacaagcac ttgggctgcg attgatccca atccgacgaa 577801 aaacgcagct gctaaaaaca gtgttccatg cttcacaaat gctgttagtg tcaaagccgc 577861 tgcgcttaga aggagcgata caacaataag ttttttgttt tcgataatat ctcctaaagg 577921 gacaaggaat agtaagccgg caacgtatcc gatttgggtg agtgtgacaa tcaatccagc 577981 accgcttgga gaaagtccaa ttgccttact aattaatccg accaagggtt gtgcatagta 578041 aagattagca acaatgatac cgcatgcagt tgcgagaaga agggttaaac tgggtgaaat 578101 cctctgacct gcttgtttgt ttccattagc catatgaatg aactcctttt taagtggttt 578161 tttgagtgta atcatgactt ctcacaagtg attttataaa ctgaacgttc agtttcgtcg 578221 attaataaaa ataatatact aaacgttcag ttttgtaaat ggatttctgt tttctttttt 578281 tattcaattt aagtatactg aacgtatagt ttatattgcg ggaaggaatg atttatgtgc 578341 agagtaaacg agggcggccg cgtgatgaag gaacgcataa ggcgattctc tctgcagcct 578401 atgacctatt gctggaaaaa ggcttcgatg cggtgacagt cgataaaatt gccgagcgtg 578461 cgaaagtgag taaagcaacg atttataaat ggtggtctaa caaggctgcc gttatcatgg 578521 acagctttct ttcgaccgcg acggacaggc tgcctgtgcc tgatacaggg tcgtcagtac 578581 aagatatagt aacccacgcc acgaatttag ctaggttttt gacaagccgg gaaggaaccg 578641 ttattaagga attaataggt gcagggcagt tggatgaaaa attggcagaa gaatatcgca 578701 cgcgattttt ccagcctcgc cgcctccaag cgaaaggcct tctagaaaag ggaattcaga 578761 aaggtgaatt gagagagaat cttgatattg aagtaagcat agatctcatt tacggaccaa 578821 ttttctatcg tctgcttata acaggggatg aggtgaatga ttcctatgtg cgtgatttgg 578881 tgatgaatgc gtttaaggga gttcaagcta cctctgctac agagagtatg tagctgataa 578941 gaactgcaaa agctgcggat tatatgacaa attggttcca tcgtacagtg aaatataaga 579001 tttttgttgc tgagcggaat catcgaggga aaagttctct tatcggatgt cgaaaaagaa 579061 gtcattcaat cgtgaataca taacatcata ttattacatt ccttttcatc gattggaaca 579121 agggttctat acttcaatgg aataccgcaa agttggagta tttaaacaac aggggaaaat 579181 cgatggccat tatgtaggtg tcatggcaat ggaaaaaata cttgcaatgt aaacaggcct 579241 ctaaagagac ctgtttttta atatccagat gattgtctag tttcagcttg ggctctatga 579301 ccactcccat aactgaaata gtctaatatt tataccagaa gggattgttt atataaataa 579361 aagtttatat aatgacgggg gcgctaagga aacgcgggga gcgactcagg ttttcgtttc 579421 aaagttttga tccttaagat atacggagcg ctacatatgg aaacgtaaag gggaatgtat 579481 aatcatttgg cgtgtatata acgatttgct tatatattga tttgggaagg aggagctcat 579541 atgacgattg atgttgcggc gatgactcgt tgtttgaaaa cacttagtga tcaaactagg 579601 cttatcatga tgagattatt tcttgaacaa gaatattgtg tctgtcaatt ggttgatatg 579661 ttcgaaatga gccagcccgc cataagccag catttgcgga aattaaaaaa cgcaggtttt 579721 gtgaatgagg acagaagagg ccaatggcgt tattattcaa taaatggttc ctgtcctgag 579781 tttgatacat tgcaattgat cttacatcaa attgatcaag aggatgaatt gttaaaccat 579841 atcaaacaaa agaaaactca agcgtgttgc cagtaaggag gcattagatt gacatcaatg 579901 attttggcag tattcatctt tttattaact ctagtattgg tcatatggca gccgaaaaat 579961 ttatctatag ggtggtcagc ctgtggaggc gcagttttag ctctaatagc aggtgttgtc 580021 aattttcatg atgtgttaac tgtgacaggg attgtttgga atgcgacctt ggcttttgtg 580081 gccatcatac tgatatcgtt aattcttgat aatatcggtt tctttgaatg ggcagcgctt 580141 catatggcta aggctgcaaa aggatacggt gtgcggatgt tcgtttatgt atctctatta 580201 ggagctatcg tcgccgcgtt atttgcaaat gacggtgcag ctcttatatt gacaccaatc 580261 gtattagcga tggtcagagc attacatttt aatgaaaaat tagtttttcc ttttatcatt 580321 gccagcggat ttattgcgga taccacttcg cttccttttg tagtaagcaa tttggtcaac 580381 attgtttcag cggactattt tcatattacg tttattgatt atgcatccag aatggttgtc 580441 ccgtacctgt tttcgctgct ggcgagcatc attgtacttt accttttctt tagaaaaagc 580501 ataccaaaac gctatgatct gactgaggtt aaaaaacctg ttgaagcaat taaagatcaa 580561 aacatgttca gactgtcatg gtatatctta gggctgctgt taattggata ttttgcaagt 580621 gaattttttt ctatccctgt atcagtggta gcgggcagca ttgcaatcat tttcttaatc 580681 gctgcgcaaa agagtccggc cgtccataca aagaaagtgg tgaaagaggc gccatgggct 580741 atcgtattct tttcaattgg catgtacgtt gttgtgtatg gtgtccgaaa tgccggatta 580801 acggatgtcc tttcagatgt gattcaagcc gcagctgatc aaggattgtt tgctgggaca 580861 attggaatgg gctttattgc ggcgattctt tcttccatta tgaataactt gccgactgtt 580921 atgattgacg cattggccat tgccggtaca gatacacatg ggatgatgag agaagcgctt 580981 atttatgcaa atgtgatcgg ttcagattta gggcctaaaa taacaccgat tggttcctta 581041 gcgacattat tatggcttca tgttctttcg cacaaaggta tgaagatttc ctggggcacg 581101 tattttaaaa caggaattat cctcacgata cccactttat tgatcacact tgtcggcctg 581161 tatatttggc tgctgataat ccattcttgt ttctaaaagg acaaggtcac tatatcaagg 581221 aaaacaatgc actggtaact cttgccgcag ccaaatggct gaagggtggg ggagaaaata 581281 ccttggggct aagtggaatg tgtacagcgc aggaatcgaa gctcaaggat gacatcgagt 581341 gctgtcaaag caatgaaaga agcagggatt gatatttcaa atcaaacatc ggagaaattt 581401 gatgatccgg caaaagcaca cggaacagaa gaagtgtttc caaagggtcc gtgatgaaat 581461 tggtgaccgt ttaaaacagt ttgctgtaac tggggaataa agaatcgata tattcagcgt 581521 tttcttgggt tatataatac aatgtgttgt tcaacaggtg tctgcgagct gagtgcagac 581581 acctgttttt gtttttattt gtctgagatt cgtaacaggg aagttattta gctggtgaca 581641 gaggaaaatt gatttgtgaa cagaatcatg aaggagacgg tgttttaaag gagttgtctg 581701 ttttgcagga attaacaaaa aaaaaataca gtagcttaaa aacaatgttt gatgacaaat 581761 attgtcccac atttgtctat tcaatattag accaaaccat tccgggagct gtttatgcag 581821 atgatcaaac ctttcctaaa tcgtttttta taggaactga atcaggcatt tattttattg 581881 cgggagacca agggaatcgg gattttcatg atttcattgc aggatattat gaagaacaag 581941 tgaaatcatc aaaacgattt accttgtttt cttccagtga tacatgggat agcgtactga 582001 aacccatact gaaagatgac ttaaaccaaa tgagaagagc tgcattttct tatcaaccaa 582061 aatctttcaa aaagactttg caactgccaa aggggcttgt attgaaaaga attgacgaag 582121 acatcatttc acatagcaca gcgtttaaca gcgcgtatta tgaggagtat tggaattctg 582181 tctcacagtt tgcttcaaaa ggttttggat ttgccgtatt acatggcaat cacgtagtaa 582241 gtgagtgtac ctctatattt ttagggcata atcgagcgga aatggatatc tatacacttg 582301 aagaatatag aggactgggg ttagcttatt gcgtagcaaa taggtttata gcgttttgta 582361 tggaaaatgg gattgttcct agctgggatt gtgatatttg caacaattcg tccattgcat 582421 tagcagctaa actagggttt aagacggtaa cggaatacac tatttactac tctggctaac 582481 cttaatgaaa gaaccttaaa aggagatacc aaccgatgtt ggtatctttt ttgttttaga 582541 gtttttttac ccttttagca gaaaaatggg tgatgaaaat cttattcatt ttatttactt 582601 ttaggtaggt aaaacatacc ccgccaactg taaccactcc gcctagcaga gagagcagtg 582661 tgggtatctc gccgatccag agccaagata tgatcaaggc taaagccggt gtaacataaa 582721 gtgaaagggt tgcttctgaa gcaccgacga atgaagtgac atatgctagt gcgaagtaag 582781 gaataaccgt cggcaataat cctaagtaaa cgatagacaa agttgcgctt attgaagcgt 582841 tcatcatctc ttcgcctaag cctggcagaa acacaagcat aggtattgtt ccgccccaaa 582901 tggtgaatgt aacgaatgga ataaaaccat atttttttat atagcgggct tgaaaaacga 582961 aataaatact ctccgaaaat gctgccagca ggatgaccaa gataccgctc attgaatatg 583021 taaagtctcc cgccccaaat gcaatcaata atacacccaa taaactgatc atagagccaa 583081 gccatttcgt aaatccaaaa tgctctttat aaaacaggcg ggatagcatg gctgagaaga 583141 tcggtgccgt agtaacgagt aagcttgcaa ctccggcact aactgttttt tcaccgatgt 583201 tcagcaaaat gtgatagaat gcaaatccta aaaaccctaa aagaaaaatg gcaggaatgt 583261 ctttcaagtc gggtaggcgc atctgagtca aaacagcaaa aagcaataat gccatagagc 583321 cgattaacaa acgaaataaa gcaaggtgtt ctggcgtgta cccttcaagt cctgcgcgaa 583381 ttcccggaaa agcagatgcc cataaaccaa tcatgagact atgagatatc attatttgaa 583441 ctgttttctt tcgcattcct ctcactcctc tttacaaaaa ccaaccagtt atttaatgtg 583501 tttctatact aataaagatt tgatgatatg gcttcaacca gttcaataga ttttgaccca 583561 accaatttat tttaaggaga ccgattctat gagctttcca gaagaaaaaa agatgaaaaa 583621 gctccctaag tacagacaaa tcgttcattt tattaaagag aaaataggaa atggagagtg 583681 gccgattgga agcaagattc caagccagcg cacgcttgca aaagattttc aggtaaatcg 583741 gagcacagtg attacagcgt tagaggaatt gatggccgat gggctaatag aaggcacaat 583801 ggggaaaggc acagttgtta tcaacaacac atggacactg atggctaaga attctgctcc 583861 cgattgggat caatatgtca cctctggcat tcagatgcca agccgaaaaa tcgttcaaga 583921 gataaatcaa tcagaatcaa atacagacct tatacagctc agtaaaggtg aactttcagc 583981 tgagattttt cctttggctg ttatgaaaga gatgatgggg aaggtatctc aacacatgga 584041 ggcattcgga tatgaagaac caaaaggtta cttacctttg agggaggcat taagcaacta 584101 tttaaaaacc attggaatca acgtctcatc ttcttccatt ctgattgtct caggagcgtt 584161 gcaagccttg cagctgatat caatggggct gttacaaaga ggatcaaccg tttatcttga 584221 tcagccctcc tacctttatt cattacacgt atttcaatca gctggtatga agctgactgg 584281 acttcctatg gataatgaag gacttttgcc tgaaaatgtt catttaacaa gaggagagcg 584341 gggaagggct atcttatata caaatccatg ttttcacaat ccgactggta ttcttatgtc 584401 taaaaagcga cgggaagaaa tcctagcagt aagtgagaat acacagcttc ctattattga 584461 agatgacatt tatcgtgagt tatggatcga tgaaattccg ccatatccta ttaaaacaat 584521 tgataaaaat ggacacgtac tgtacatagg aagtttatcg aaaacattaa gcccaggttt 584581 gaggattgga tggatcgtcg gaccggaacc ggtgattgaa cgtttatctg acattaaaat 584641 gcaaacagat tacggatcca gttcgctatc ccagagagta gcggcagagt ggtttacttc 584701 cggccactac cagcagcatg tagaaaaggt taggcagcaa ttaaaggtga gaagagaatt 584761 ggccttgagt gctttagaaa ctcatttgaa agaagtggcg acatggaata tcccaaaagg 584821 agggtttttt gtctggataa aaatattgcc ttccatatca atgaaattac tttatactaa 584881 agccttatca aaagggattc tgatcaatct cggcagtatc tatgctcagg aaaaagggaa 584941 ttatattcgc ttatcatatg cttatgcatc tcttgaagac cttcaaaagg ggatttatga 585001 gttgggttta atgattaaag aattggcaag caggtaactt ttatatcctt aaatggatgt 585061 ttcactaaaa aagagatcaa gcctaatgat cgcttgatct gataataaca agggttacta 585121 gaatagacca aatcatggtt cggtcttaaa ataatcatgt ctctgaacga aaagtctttc 585181 cgacttctct tcctaaacca aagtagtgtc tgaaattata gataagcggg ctccatttgg 585241 aagggttgat atggttttcg tccagaatga tactttcctc ggcatgaaaa tgtagtgcct 585301 gcgtctctac aattgcgaat gacgattcat attctggaag ccgaatgtgt ttcacttcgg 585361 cttcgatttg gatagggcat tctttaattc gtgttggtga tactgttttt gattgtaaag 585421 gcgttaaccc tgctgcctcg tatttttctt ttttatatgt aaatccgatc tgcttcttta 585481 aaggcggtat actctttttt ccgctataag atgaaattct ttcaacgttt tcccataaat 585541 ccgggccagg caagtttatg acacactctt tgtgtctttc caaattgtcg atggcttttc 585601 ctcccagtcc tactccaagg attatataat gtccaagagc ccaagaagaa gacataggac 585661 taatattagt ggttccatcc tcattcaatg tggttagaag aaatgtcgag gtaccataat 585721 acatgatctt gggtttgatt tccttaaatc gacgagtgtc ttgttttttg atgtccaacg 585781 ttttttcctc cttgtcacgc ttacatttat attgtaaagg attaacattt caactatcat 585841 cgaaatatga atgtaaggag gaaaatcatg aatcctaata ttgcaaaaat ctcttcgttg 585901 ctatcagatc cctcgcgttc ttccattctt ctcagtctga tggatggaag gatacaccct 585961 gcgggagagc ttgcatatct cgctaacatt aaacctcaaa ctgcaagttt tcacctgaat 586021 aaattgcttg aagcaaagct gattagcgta gagaagcatg ggagacatcg gtattacaga 586081 ttggctgact cagatgctgc aaatgtgatc gaacaattgc ttcatattgc gcctaaagca 586141 aaagtcaaat ctttaaaaga gtcaaaagag aaaaaggact tgcatttcgc ccggacctgt 586201 tatgatcatt tggcaggtta tgtgggcgtg caaatggcac attcactagt tgagcagggg 586261 atgttaaaaa aagttgattt aaactttgag gtgacttcag agggtgcttt attcttttcg 586321 aagttaggca tcaatgaaga gcaacaacgg aataagagga gagcctttgc ccgctgctgt 586381 ttggattgga gtgaacggca gcatcatatt gcaggagcat taggaaacgc cctattggtg 586441 cgcatgttag aagaagaatg gatcgttcgt atgcctaaaa cgagagcgat taggattaca 586501 caaagcggga aaatcgcgtt tgaaaagcac ctaaacgtga agatttagga ttttgaagcg 586561 gaaacatcag atgatgaggc acgatatcta ggaggagtaa gatttgttct aatcttactc 586621 cttcttctta ttttgaagca gctcgattcc ccattgcaat agagatgcgg ttccaactgt 586681 ttatttgatt aatgatcaga acaaggtcaa catattgttc ctcatcataa tgttcccgca 586741 cccgatgata tagctcatca ggaacccttt tagatggaat gagcgtgatg tgttcagata 586801 gttcgagagc cgctttctct tcaggtgagt aaaaatcaca ttcattccaa gcatgtaaac 586861 agtaaattcg ctgttcagtt tctcccattt tgcgggcatc ggacgtatgc atatctatgc 586921 agaaggcaca gccgttcatt tgagagactc tgattttgat tagttctctc gtcgttcggt 586981 taattgagga ttgtttcgtg tatttctcca tatccatcat gattttcata ccttcaggtg 587041 caatctcata gtaggacact ctttgactca taaagcaaga ctcctttcca tagaatacct 587101 agattgtatc ccggtattga tcattttacc aatgtgcggt ttgaatgaca gctgtttcag 587161 cgtcttttgg aaagaagctt ctttgaataa aaataagggt agccagcaat gatgagtgga 587221 gctgctaatg caagcagtat ccatgagcct gattggctgt ctctagtgac tctaatgaat 587281 atataagtac cgatcagaaa atataataaa gcacctagaa accaatacat gttcattcct 587341 ctttttcctt gctttttggt tgcgcatttt tgtctgtcat atggcttaat cgatcagggt 587401 tctgattttt taataccttt tcggtccgga ttccttttct ctttaatgat aaaattgtga 587461 gatcaatcga tttcaatgat gatcattcct tcaatgaata gtaagttcct tatgatttta 587521 aaggtaaatt tgaaaagata aaacgtacat agaggcagaa cgttcatgta cgtttgggca 587581 atgatcactt gttggaaact ctaatgtttc cctgcacctg atattgttgt gttccttctc 587641 ttcctataaa atgattggat acatgtatgt ttgcacgttg aaatatgggt tcgattttca 587701 tgaatctcta ttcggtgaaa caggtaaagg aagtggataa ggtttgctta taaggaatcc 587761 ttttaaagat aaatattact cacatgatag gcgggcatta aacatgcttg cactcagagt 587821 gccgggcctg gcttttattc tcatgatcta tatagcctct atcgtgctgc aatttgtttc 587881 tgggggctgg tccattttat tgctttatgc gtttaccata ttaatcgcca tttttgcttt 587941 gcttcattgg cactcatatc gctgggttaa gaaaagagtg attctgtatt tcgcggtaca 588001 aggtttgatc acctttgcac ttgctaatct catgactggc ttctttatac ttgtgattat 588061 cggcctttat gcatttttaa ttggacaaat tataggaatg gcagacagaa gaaggacttt 588121 tctcattctt tatctattgc tgctgctggt cataaattcg gcgtatcacc ttcataaagg 588181 tgaagttttg cattttattg ttattgctgc gccgatcatg attgtcatca tcacttatgc 588241 cgcaacattt tttgcccaag tcgatgaaaa aataaaagct caattgactc ttgaaaggct 588301 ggagctggct catcagcagg tagaacagct gacgctgcag aacgaaagac agcggatggc 588361 ccgagactta cacgatacgc ttgctcaagg tcttgtcagt ttaaatatgc agctggatgc 588421 gattcatgtt catctcgcca aaggcaacac agagagagcg aaggaaatca tacaacaatc 588481 gatgaaaaga gtgaaaagca caatagctga tgcacgttca gctattgacg atctccgcag 588541 caaatcagaa gaaatcggtg ttttaaaaga aagaattacc tcgctaatgg atcattttat 588601 agagtcgaca ggcatggctt gtttattaga ttacagattg catcaggtgc tggatgtgcg 588661 tacagctgaa aactgttatt acatcattgg agaatgcatg acgaatgcgg caaagcatgc 588721 tgaggcgaaa acaatctgga tatccatttg ggatgatgaa aagggaaggc tccatttaac 588781 agttaaggat aacggcaagg gatttgatgt tgaaaaagga aagaaaaaga gaggacatta 588841 tgggcttctt ggcatacaag aacgcgtcag ggcaataaat ggccaattca atatcaagag 588901 tacaaaattg aaaggaacac aaattgagat cactgtacca attcagggag agatgcaaga 588961 tgaataaggt tttaatcgtt gatgaccatc ttgtcgtgag ggaaggtctg aagcttttaa 589021 ttgaaacgaa tgatcaatac accattatag gagaggcgga aaatggaaaa gtagcagtcc 589081 gtcttgcaga tgaattagaa ccggatatca ttctgatgga tttgtatatg ccggagatga 589141 gcgggttaga ggccattaaa caaataaaag aaaaacacga tacccccatc attattttga 589201 ctacatataa tgaagatcac ttaatgatcg aagggattga attaggagcg aaaggatatc 589261 tgttaaaaga tacgagttca gaaacccttt ttcacacaat ggatgcagcc atcagaggaa 589321 atgtgctatt gcagcctgat atccttaaac gtctgcaaga aatccaattt gagcggatga 589381 aaaagcagcg caatgagacg cagctgacag aaaaggaagt cattgttcta aaagcaattg 589441 ctaaaggtct taaaagcaaa gcgattgcct ttgatttggg cgtctctgag cgaacagtaa 589501 agtccagatt aacgtccatt tacaataaat taggcgcgaa ttcaagaact gaggcagtaa 589561 cgattgccat gcaaaaaggt attctgacaa tagacaacta aactgcatat ttgaaaattg 589621 cccaaacgta catgcccgaa tgtacgtttt tttcatttca ttgtcaacta caatgagaaa 589681 gaatgtgatc aagcaatgtg ttgaaaggag attatcatgt caaaaatgtt atatacatta 589741 ggaggatggg ttgctcgcaa tcgcataaaa gcaatatgtg cgtggatcgt tgtgttagtt 589801 gctgcgatag gccttgcagt gaccttgaaa ccaagttttt ctgaggatat gtccatacct 589861 gacacacctt cggaaaaagc gatggatgtg attcaaaaag aatttcctca tggtcctgat 589921 aaagggagca tacgggttat tttcggtgct ggtgatgggg agaaacttac tgggaagcca 589981 gcaaaaaaag caatagaaga tacgttcaaa gaaatcagta aagatgattc tgttgactcg 590041 attgcaagtc cttttgtgac agggacaatc gcgaaagatg gcacagttgc ctatgctgat 590101 atccagtata aatcatcagc agatgatata aaggattact ctatcaaaca cttaaaagac 590161 agtttgaaaa tggctgatga tgaaggattg caaactgagc taagcggaga tgtaccggga 590221 gcggagatgg agataggcgg tgtctctgaa attgtcggca ttatcttggc ttttgtcgtt 590281 ttagccatta cattcggttc tttattaata gcaggtttgc cgattttaac tgcactgatt 590341 ggtttaggtg taagtattgg actggttttg attgggacac aagtatttga tattgcttct 590401 gtcagtcttt cattagccgg aatgattggc cttgctgttg gtattgatta tgctttattt 590461 atttttacga aacaccgcca gtttttaggc gaaggcatac aaaagaatga atcaattgcg 590521 agagccgtgg gaacagcggg aagtgcagtg gtttttgccg gacttactgt tatcgttgca 590581 ctttgcggat taactgtcgt taacattcct tttatgtctg cgatggggct gacagcaggg 590641 cttagtgtac tgatggctgt tttggcttcc atcacacttg tgcctgcggt cttatcgatt 590701 gcagggaagc ggatgattcc gaaatcaaac aagaaaatag aaaaacaaag cactgaaaca 590761 aatgtctggg gacgctttgt caccaaaaat cctatcatgc taagtgtatg cagcattctg 590821 attttgatcg tcattagtat cccatctatg catttggaac tgggcttgcc tgatgctggg 590881 atgaaagcta aggataatcc ggatcgccgg gcatatgact tgcttgccga aggctttgga 590941 gaaggattta atggccaatt aacaatcgta gcggatgcca caaatgctac agaaaataag 591001 gcggaggctt tcgcagatgc agtgaaagaa ataaagggct tagaccatgt agcaagtgtc 591061 actcctgcaa tgcctaataa agaagggaac tttgccatca ttacggtcgt tcctgaaaca 591121 ggtccaaatg atgtcacaac gaaagatttg gtacatgatg tacgcagttt atcagataaa 591181 aacggagtag atttgcttgt tactggatca actgcagtga atattgacat ttcagatcgc 591241 ctgaatgatg cgataccggt gtttgctgta cttattgttg gctttgcgtt tgtattgctg 591301 accatcgttt tccgttcgct gcttgtgccg cttgttgctg ttgcaggttt catgttgacg 591361 atgacagcca ctcttggaat ctgtgtattt gtcttgcaag acgggaatct catcgacttt 591421 ttcaaaatac ctgaaaaagg gccgatactc gcgttcctgc cgattttatc gattgggatt 591481 ctgttcgggt tagccatgga ttatcaagta ttccttgtca gcagaatgcg tgaagaatat 591541 gtaaaaacaa acaatccagt acaagccatt caggctggat taaaacacag tggtcctgtt 591601 gttacagcag ccggcttgat catgatcttc gtttttgcag gatttatctt tgcaggcgaa 591661 gcttctatta aagccaatgg gctggctctt tcctttggtg tactctttga tgcctttatt 591721 gtaagaatga cactgattcc aagtgtcatg aagctgatgg ggaatgcagc ctggtatttg 591781 ccgaaatggt tagacaagat tattccgaat gtggatatag aagggcatca actgacaaag 591841 gaaatacagc cggaaataga tcatgaacaa aagaaacaaa tcagtgtgta atagaaaaag 591901 cagatctttt atgatctgct cttttgctta tggtagtatt tagaagatga agtcggcagt 591961 taaaaggaga cgcttatggc gccatcactc attttcgata tggatggaac tttgtttcat 592021 attggcagaa gctgcatcat actagcaggc atcccaggag aagtgacatg attttttgac 592081 tttgcattca ctacttgatg ccaaggatct tgagaatcct tcttgaaaat aaaggatttt 592141 acaactgatc atataagaaa cctaaagaaa caagcacaca aaaccagctg cgggttttgt 592201 ccaagaaaaa tagagtccat aagagggact ctattttttg aagtgcccgg ctagaagcat 592261 attgcaggac tttatgaatg caaatcacta tcttataagc ccttaccgtg aaatgcctgt 592321 ttctgcattg aaaaaacgca ttacacgttc atttacgtaa gtgggttgtt ccatcgataa 592381 aacatgtccg gcatttttaa tgacttccgc ctcaatatct ggaacgaatg aagaggctcg 592441 gtgcagggct gagtggggat catagatgac ttcatgttca ccaagtaata ataggatagg 592501 aactcttgct gaacgtaatt cctcatcggt aaaaacatac ggaaatccgt cggcattagg 592561 atttggattt cttgatccat cctgccacat tacccctgcc ttaaactgct tcacaaaaat 592621 cgggtgcagc acattctgat cattcatcat ccaatttaag aatgtttcaa ctccatttga 592681 cgctgtaagg ccaagagcgt atttgtagaa atcgtgatga aatggcaaaa acgtttctgc 592741 cggactcagt atagctgcgc tttttactct ctcaggcata cgtaaaagga aattcatcgt 592801 atggagaccg ccaagcgaaa gtccgatcat gtgggacttt tcgatcccca gattgtcaaa 592861 cacatcaaga agccaattgg cgtaatccgt tcttgtaccg cttacattct caggaatact 592921 cttgttttta tcacctatga tatcaactgc ataagttctg tatttactgc tccaatcggc 592981 gatgttggga taccacatcg tcgagctgaa taatgctccg tggagtaata caagcggcgg 593041 ggcatcctct gggccgcttg caatcacatg tgtttgacca aaacgagtag atatatagaa 593101 tgatttacaa cggaccggcc aaagactaag gctttcatta taagtttgat aatagcggat 593161 accgttgtca cttaattcgg gaatactaga tgaatggttt gacatacaaa tgcccctccc 593221 aattttgttt aaatgaatgt gccgtttcgt gatggggaat ctgattttga tataacagac 593281 tttatttaca atataataca gttgttatta gacgtcaaat ccaagatgaa aaggaaaaaa 593341 acgattgaaa cagattattg aaaatcaata taacagaata ttaacctcct ttgtggagcc 593401 gcttcattaa aaccgcaatc caaatgcatg aatcacaaaa atcacaacag gagggatcag 593461 gagggaaggc agcagattca gtgttttgaa cttcttgatt ccaagaatgc ttagacctga 593521 actgaggatg agtatgcctc ccacaattgt gatttcatta ataaggtctg tattgattgc 593581 gctctccatt acttgtgcaa ataaatagat ggagccctgc caggaaaata atacaagtgc 593641 ggcagccgct attccaaaac caaaagttga agcgagcaca atggaggtga tcccatctaa 593701 catcccgttt gtcagaaggt atgtataatc tccatgcaaa gcggcttcaa cagggcctaa 593761 tattgacagc gaacctatac aaaataataa gaccgcagtt gataagccct ctgctaaatt 593821 gcttttagaa aatttgttca ccagcttgtt gaatcgtaat tctaaattga tgatctggcc 593881 tagcaaacct ccaatggcta aactcacgat gaatagaatg gggtatttac tatcaggcaa 593941 atgctgtgta atggcgttga tccccagtgc gaccgcagcg aatcccattg cctgcatcaa 594001 aatatcctgg tattcatctt taatgccttt tttgaatatc cccccgatta tgcttcctgc 594061 aatgatcatc actgtgttaa aaatcgttcc aaacataagc tttctcctcc aaaaatcatt 594121 cctgcataaa aaataaaccc tctagttagt agagagtcaa gggagatcaa aacatattca 594181 tgagattatt tgatgggcag caggatttca gtcacgtaat tatctaggtt attcgtaatg 594241 ccataatcaa tgagtgtgat ttcgattgag tcccctgcta cctcataatg atgttctttc 594301 atatatgcca gtaatttttt gtagtatggt tcggcttctg gatgtgaccc tttaaaccta 594361 atttgcagat attctcttga aggaaagatg atttctgaag aagttttttc attttcatct 594421 tcaagaatca taaatatact ggaatatttg tcaaactgtt ttgctttcac atttgctgca 594481 gaaatggata aaccaatctt gcctatgaat atatcttcgt ttacattcag gtgggttctc 594541 aattcagcta acgaatgttc gatatcatgg ccgagaacat attcatgctg caaataggcc 594601 acacgcattg cgggaagttt gatttttgaa atttgatgta acggcatgtt aacggcatct 594661 tctatatgtg tgatgcgtcg ggagatcttt cgttcaatgc gttccaattc tttcttcttg 594721 cgatcaattt caacctgctg gctttttagt aaatgaagaa gagtgtttgt attttgagag 594781 ttataaaaat caagaagctt attgattggc aggcctaggg ccctcaaata cttgatggta 594841 tccagccgct caaactgttg ggtagaataa tatctatagt tcgtttgctc atctttatat 594901 tccggtttca aaaggccgat ttcatcataa taccgaagag cagagatttt cacattgaat 594961 aactttgaca cttctccaat cgaaaaaaat tccttcattc taacaacctt tctgtcctat 595021 gattgatata cacacattat atagtacggc gagtactaaa ggtaaagttt gcagcataaa 595081 gaaaaaactc cttctaaaaa ggagcttttc attcttcgaa ataaggattt acatggatga 595141 gcacttcttc tacatctgaa aactgtcttt tgatttcatt tcgaatttcg cgggcaatgt 595201 cgtgtccctg cttaattgtc aaatcatgat ccaaagataa acggacatca agcaatttat 595261 agtggccatg ttctcgcgcg cggattctat caattcgttt tacctgatca cattgaaaaa 595321 taacagcttt atattcctct atcagctcgg gatcaacact cttttccatg agcacatcaa 595381 cagacggcct gattaattcc attgaaatct taaaaatgag gtaagcaacg attgcactgg 595441 caatggcatc ggcgtacaac agataggacc atccacggct gtttccgatg atagccaaca 595501 ggacgccgat aaaagcggca agagaggcaa cgatatcgcc tttatgatcg tacgcaatcg 595561 ctataatcgc tttgctgttc cattttttcc cttgctttat agaataacga tataagattt 595621 ccttagccac gtacgaaatc agagccgcaa acaatgcgct gtattgggga acgcttggcc 595681 ctttaacaaa ggacagaatc gcttctatga ggatataaac ggatacgatc actaagataa 595741 ttcctacaat cgcctcacta atgacttcag cttttccgtg accaaaagga tggtcttgat 595801 cgggcggttt attggaaatt ccgatcactg ccaagactgc aatcgaagca acgacatctg 595861 ccgcggaatg tattccgtct gcaaacacgg cttcactatc gcctaccagc ccaaaaaaga 595921 cctttcctgc cattaagatc agattggcga tcaatgcaat caaagcaact tttctgctta 595981 tttgttctct ttcacttgcc attttttcct cctataaaac tgcacaaaaa aataggagtg 596041 ctctatatac gctctccgta tcctttcctg tgtaatcact ttgtttatca taccaattca 596101 atttcgagtg ggtctatagc aacgttgttt cctgtttact aataaataag gtgacagaaa 596161 aaaagttgga gctatgctaa aaaggtcata cagcaaacaa atgagttctt atgtaacaac 596221 agtgatgatt cgctattaaa atgctgccgt cagtgaaaaa tttccaccta attttcaaaa 596281 acctattgac atgagaagat ctgtatttta ctattatctc atattcaaga tattttaatt 596341 tgagatattt ggtcggaaag atcagcgatc aagcgcaact ctaagtgttc aatcgttgtc 596401 agttctttta cacaatattc aatatgattt tttataacat aatatctcga attcgagata 596461 aaagggagtg tagcgtaatg gctgaattta ctcatttagt caatgaaaga cgatctgcaa 596521 gcaattttct ttcaggtcat ccaatcacaa aagaagatct caatgagatg tttgaattgg 596581 ttgcattggc accatcggct tttaatttgc agcatacaaa atatgtgacg gttcttgacc 596641 aggacgtaaa ggaaaagctg aagcaggccg caaacggaca atataaagtg gttagctctt 596701 ctgcggttct cttggtatta ggggataagc aggcatatca acaagcggcc gatatctatg 596761 aaggtttaaa ggtattgggg atattaaata agcaagagta tgaccacatg gtgcaagaca 596821 ccgtttcgtt ttatgaaaac aggggagaac aatttaagag agatgaggcg ataaggaatg 596881 cttcactttc tgcgatgatg tttatgctga gtgctaagga aaaaggctgg gatacctgcc 596941 cgatgatcgg ctttgatgcg gaagccgtaa aacggatttt gaacatagac gaccaatttg 597001 aggttgtcat gatgattacg attggaaaag aaaaaacaga gagcagaaga ccgcgcggct 597061 accggaagcc tgtgaatgag tttgttgagt atatgtaaaa ggagcggata aaaatggcta 597121 aaaaaacgat gggaattcat catattacag cgattgtcgg tcaccctcaa gagaacacag 597181 atttttacgc aggagtgctt gggcttcgtt tggtcaagca aactgtcaat tttgatgacc 597241 caggtacgta tcatctttat tttgggaatg aaggcgggaa gccgggaaca atcattacct 597301 tctttccgtg ggccggagcc cgccaaggcg tcattggaga cggtcaagtt ggcgtgactt 597361 cgtatgtcgt gccgaaaggg gctatggcat tttgggaaaa gagactagaa aagttcaacg 597421 ttccctacac caaaatcgag cgctttgggg aacaatatgt agaatttgat gatcctcatg 597481 gactgcactt agaaatcgtg gaaagagaag aaggagaggc taatacgtgg actttcggag 597541 aagtaacgcc cgatgttgcc attaaaggtt ttgggggtgc aaccctatta tcagagcagc 597601 ctgacaaaac cgctgacctt ttagaaaaca tcatggggct ggagcgagtc ggcaaagaag 597661 gagacttcgt tcgttatcgt tccgccggtg atatcggaaa tgtgattgac cttaagttaa 597721 cgcctattgg ccgcgggcaa atgggggccg gaacggtgca tcacatcgct tggcgggcta 597781 acgatgatga agatcagtta gattggcaaa gatatattgc ttcccacgga tatggtgtaa 597841 ctcctgttcg ggatagaaac tactttaatg ccatttactt cagggaacac ggggaaatcc 597901 tgtttgaaat cgcaactgat cccccaggct ttgcacatga tgaaacacag gaaacaatgg 597961 gcgaaaaact gatgctgcct gtgcaatatg aaccgcatcg cacacaaatt gaacaagggc 598021 tgctgccgtt tgaagtaaga gagttagatt gatttgacac ataaaaaata aagaaacata 598081 tattcaattg atgattgctg gatggtactg tcagcaaaga atcagataaa atcaaagatg 598141 aggagagata caaatggaag atgcaggact gttgcttatt cgtataatga ttggtgtggt 598201 gtttttgttt tatggcacac aaaaattatt cggctggttt ggcggatacg ggattaaagg 598261 aaccggacaa tggttcgaat caattggggt gaaaccagga aacgttgcgg ccgctctatc 598321 aggtcttggg gagttagtaa gcggaattct atttatttta ggcgtattcc tcccgcttgg 598381 agctgctatc ataacaatca tcatgttagg tgctatcgta aaagtccatg gagcgaaagg 598441 ttttgcgaat ggcgccggag gttttgaata taacctggtg ctcattgcag tttccatagg 598501 ggttgcactc atcggttcag gagcttacgc tttgcatttt taatacgaaa gtatgtaaga 598561 acagttgctg cttgtcagta actgttcttt tattttcaca ttttcggcaa gcttgcaggt 598621 actctgcaaa gcaaaaaagc ggatatcata aatataaatc tgtatagtga atgatacgta 598681 ttgatgagct tggtcatgaa aaacagacct atttgaagga gtaaatggat gaaagagatg 598741 acaggattac attcattagt ttctatagaa aactttatca aacagcacaa attcagtttt 598801 atttatatat caaggcctgg ctgtacagta tgtcacgcag ttctgcccca gctcagaata 598861 gtattggatc agtttccaaa catcaaattg gggcatatca atgctgacga tgtagcagag 598921 gtcgccggca gattttcagt tttcaccgtt cctgtgcttc ttttgttcat tgatgggact 598981 gagtttctaa gagaagcccg ttttgttcat tttgaacagc ttgaacaaaa gctgaaaagg 599041 gtttatcgat tatatgaagg cgaataaagg aataaggcaa aaaaagaact caaatgagtt 599101 ctttttttat tcttcactag gcgaagaagg gttatcaacc tgcccttgat cacttgtatc 599161 attatcacaa cttgctgaaa taataattga atgagaagga gagtaatctc ctaatgtgaa 599221 attcactccg taatttttgc tgttcgcagt atggctgttt tgcaagtttt gtccgatatc 599281 tgtattggcg ttttgtgtca ttccatttat cgtgagattt gagatgttga tttgagatcg 599341 catgcttcaa aaactccttt cactcagaag tagctgtcat aaaggacgct ggcagtctat 599401 ttacttctat gatattgcgt ttttatatca ttgcatcaac ataatggtaa aaataatagc 599461 gagtgaatga tcatcttttg aagatgatca acctatcagc agaaataaag ccgcctgata 599521 aagaggcggc agatcgttat atgtcatcta tgaatttgat gtatcgtttt tcgtttgcct 599581 gaaggataag atagtcgttt ttaatgatga gtaggagcct atagcagcgt agccataaaa 599641 ccagcccata aatacgccag aaaagaggct gtgtcgatgg cttatgaaaa cagaaatgac 599701 aaggcctgtt attaaggcaa ctgacggtac aaaagttttg gggattttca ataatatttt 599761 gaggatttgg gttatcaata tgatgattgg aacagctatc acagcatccc aaaagttcgt 599821 gtgaataatt ggaaaagcca tacggcacct catgaagtgt ttatttctta atttttacgc 599881 taaaagcttg gaaagcagct cttggatcgc atatgttaca ttttgggctt gattggcgga 599941 gcttgtttgg cttaaagcat tggattcaaa aaccaaacct gtattactcc caccggaacc 600001 ctctgttgtt ttagacacag agaacgggct gatggaaact gcaaatccgt tattaaaaac 600061 gctgttcccg gatatcgaat gaatataaac tgggaatttc atcattcatc tctcctctct 600121 gttatgactg tttatacaat atggtgtgtg agcagcagtt gcttaaacaa aacggcaaaa 600181 actttcagta agagacaaaa acctgcaaaa tgccacaagc gccttttgtt aatgcagctt 600241 tttagggacg ttttttttat tttttttgcc aacttcatca aaaatattct gattgccaga 600301 ctgggcttgt ccgtccttat ttatgaaatc ggggtgaatg agttttttca gatccctgac 600361 tgttaaaggc ttggcgtcat cagttaattc tattcctaat tgcccgtttg cctctaatgt 600421 cgcaattttg acatcttgta tagccgtaac gccgtgaagc cttagctgca tttcaagctg 600481 gtcagctgta agtctcatct tctttaagtt ttcgatatga agctgtccgt tttcaatgac 600541 gatttttgct tttccggtta acatcttttc aatggtgttc gatttcattt ggatccattc 600601 cataacgatg agtgtgcttg tgaaaattgc cgctgcaatt aatgttttga agaggctgta 600661 ctcgatgatt ggctgaacga taatagttcc gatcgaaatc atgacaaccg tttgagtcga 600721 cgtcatttgt gcgattgatt tccttcctga aattctcagc aaaatgaccc cggctacaat 600781 gagaacaaga gattcccaag tgaaattcat gctaccacct gaccaatgat gaattagatt 600841 tgtcatggga ttggcttttc ttccggccaa tcgcaattta atatatccga aaggcagtcg 600901 gttcattctg tcctgaaccg aacaatattt ttggtataga tggatatatt aagccaaaca 600961 atgatagcaa caggagtttt ttggccgaaa caatctggga agcggggagc gccataacat 601021 gattgaactt gaagttgtca ttagaacggt tgccagcttt ggcttgctgt taatcgcaga 601081 acgaatttta ggcaaacaga caatctctca aatgacgatt tttgatttta ttgcggcgat 601141 cacactaggg gcgattgctg ccggattagc ttacaatact tcaataaaac cgcacaatat 601201 ggccatttcg tttagtattt ttgtgctaac catttttcta atttcgtttc tgtcgataaa 601261 gaacaggaag ctgaggaaat tttttgccgg agatccaaca gtgctgattc aaaacgggaa 601321 gatacttgaa tcaaatatga ggaaaatgcg ttacacactt gattatttaa atcagcaatt 601381 acgggaaaaa gaaatattta atatcgaaga agttcttttt gccattcttg aaacgaatgg 601441 tcagctgact gtgttaagaa aaccgcaatt ccggcatgtg accaaacagg atttaatgat 601501 tgcggtaaac caagaacaaa ggcttccgat agaacttatt atggacggag aaatcattga 601561 gaataattta aagcagaatc gtttgacgga atcctggctt ttggaagaat tgcgaaaaag 601621 agacataaag gtgaaagaga ccgtgtacgc agtgctgctg ggtaatgggg atatttatgt 601681 ggatcaatat aaagaccata tatcagtccc tatggataag gaatgaagga acaatcaatc 601741 ttaaagcccc ttattgaacg caacggtttc aacttgtctt gggtacgaaa tatgcagaag 601801 cccgtttaac agctgaatct gtaacaaatg agtttcagcg gcttcgggaa gctgaatgat 601861 tcgctcaatt tctccgtaat accgttcacg cagcacttcc atttcggctg gaaaaacagg 601921 cgtgatcgtt cctttgatca gcagctgggt tttagacagt aaacggatcg ttaattcttc 601981 ctcatacaca ccgggcattt ccacaatgat aaaattatat tcctcatctt gataaaagtc 602041 gtaaacaaac gtagaagctt cggaatcaaa aaaatgttcc ggggctttat atttgagcac 602101 atttgtccaa aagtcacttt gtttatattc attcgtaatc tcaagccact ttcgaatttt 602161 ttcgaaatcc atatgagatt ctccttaaat ttgatttgaa atcggcgcag aagggtttcc 602221 gatttggtct tggtcactaa cgtctgaatc aatatttcca gtgtttaaaa gtgaagacgt 602281 aggcgaaaga tcccctaagg aaaagtttgc tccaaaatat ttgctgttcg cagtatggct 602341 gttgtgcaca gtcggaccga catctatatt tccgttttgc gtgacgccgt tgatcttaat 602401 atttgcgata ttaatttgat atggcataga cgaaacccct ttaatctaaa attggcggtg 602461 gtgcaatcgg aggagcatta acgttggatg tatcagagtt gccgatagat gtctggtcat 602521 ttacatcagg atcgtttaag aagttttcca ttacggattc tgtaggtgat gtatcaccga 602581 aagaagagtt ggtcccttga gatttttgat tgttggtagg gctgttataa gcagcttcgc 602641 ctattgtaat tgaaccattg cccgaaatac tgttgatctt caaataatat aggttgatta 602701 ctgtagacgg catcccatca cacccttcca tctttctgta cagtacatta tgcgccgctg 602761 cacccaattg ttccttgcat ttacgggcaa aactctatct ggccccggag tgatgctcaa 602821 ttatcagtga atgaaaagcc attgatatag gaatcaatga attgattcag ttattcgaaa 602881 tgcatgagac cttttaataa aggaagctgg caaacaggat cagtttgaaa taattgacaa 602941 tgaagctaat gccatgaaat aatactcgtg agtaacatta ctcgtgggta ttatttttgg 603001 ggtggtccta gttgaaaagt aaaggagtag aaagccgaaa acgattactt aaagctgccg 603061 ctaatgaatt ttcggttcgg ggattccatg acgcgaaggt aagtgaaatt gtgaaaaaag 603121 ctgggttcac gcagccttca ttttacctgt actttcaaag caaagaagcc atctttgccg 603181 agttaataac cgattttcac tctcgagtca gaaagctgac agagtcactt cttctggaaa 603241 acggattaaa cacggaggat gtgtcaaaac gggtactgct agctgtagag actgtttttc 603301 aatttttgga tgaggacaag gatttaacca agatcggctt ttttctcaac ccggaagcaa 603361 aacaaatgaa aaaagacttg gcgatggttt tgaaagagaa cttagaagca gaacagcggc 603421 ttggctattt tcactctgaa ctggatatgg aaactgtcgc tgagtgtttg gtcggcatga 603481 ttgaacattt aaccgaatca tttttgttaa ccggaatcaa agatccggca agcctcgcag 603541 cagaggttgt gaatctttta atttacggga tgcttccgaa agggaatgat gtaagatgat 603601 atctattatg atgaaagtca gtttggcagt ttttatgctt gcgggaggca tcataaaggt 603661 aagccgcgtt ccctttcaag ttgagcattg gcggcattat caatatccat tatggtttct 603721 gactgttact ggcattcttg aaatagccgg ggcacttgct atgacagcgg gaatttggaa 603781 tcggtatgca gcaattggag caggtgttct gtttgtcgtt ctcatggcgg gagcaattca 603841 tgcgcatatg tttcgagcaa gacaatctgt catcatggcg atacaagcga tgatttgttt 603901 gattgtttca atcatgatca tcatggggag ttacacgtaa gcttttcact aatgtttaag 603961 aacaagccca tttgcaggaa atctcctttt cttatcgaat aatagaaagt ccaggaatta 604021 actgaatcag taaaatagag ctccatttct gtgttattcg tccggcatca gctgggcttt 604081 ttttataaag gaggaataca ggatggcatt cactttggaa gacatgactg aggaagagtt 604141 cgaagccttt cgcgggatgt ccgtgcaaaa ttttgcgaaa caaaacataa cgtcaggaac 604201 ttggacggaa aaagaggcat ttgagaaatc ggagcaggca tatgagaaca tgattccgaa 604261 tgggcgagac agcagcaatc attatttttg gaacatcaca aatgaccaag gagaaagaat 604321 gggctggctc tggctgtatg ctgatccatt acatccgcaa aaggaagcgt ttatctattc 604381 ctttggattg tatgaagcct ttcgcggaaa aggacttgct caattggcgc ttcaaacgct 604441 tgatgaaaga gcaagagagc ttggtgcgga aaggctggct ctacatgtat ttgcacacaa 604501 cgagacagcc gtctatcttt atcagaagat gggctatgcc atgaccaata tacgtatgcg 604561 gaaacagcta tgctgaaaag ccgcttacgt tacccaaata caacatgcct atctggaagc 604621 ggtggcaggg tactataagt catcattaga aagattaagg tcatgggagg cttgaacata 604681 taaagaaaaa ggacaacagc tgttgtcctt ttcaatgccg cttgaacttt ctccctcagt 604741 cttttttgtc ttgatgatcc agctctttta ttcgtttcgt aagctcattg aaagcctgat 604801 caagctcctt atacccttta tcatttggcg tcataaaact gagctttccc agcacttctt 604861 gtctttctgt ctcaagcttt aaccgaagct cctcccgctc atttctttct gaaggaacgt 604921 cgtttaactg cttttcgatg ccgttgtttg agatgacgag tttactgttt gttgtttttt 604981 cgagaaagta tcggtcatgt gaaaccgcca gcaatgtgcc gctgtattgt gacagtgttt 605041 cttccagctg ttcgcgtgac ggcaggtcga gatggtttgt cggctcatct aaaatcagca 605101 cgtctttttc ctccagaata tatgccatca gcttgatctt tacacgctca cccatactca 605161 tatgcttgat cggttcagtc cattgggcgg ctgtaaaacc taagtgcctc atcagatttt 605221 gaacgtgccc ccttgctttg aatgtttcat tctcaaataa ctcttccggt gtttgttcta 605281 aaggcaaatc aaacacctcc tgcgttaaat agccgatgtt tgcggacggc gacacccata 605341 cacttccttc tgctgtttcc tgtcccagaa tgatgttcag taatgtcgtt tttccgctgc 605401 cattggggcc tatgatcgca accttttcgc cgtgctgaat tgtaaagttt gcgtttttaa 605461 agagagtcct ttctccaaac gcttttgtta cattctgaac ttctaaaaaa cgttttcctg 605521 ttttgtgggt tgtatcgatt gaaaagcgga ctgtatattc tggggtaacg ggttccgcct 605581 ttgctttttc aagctctttt tcaagccgct tctgcttgga ttttatctgg gcatccgtac 605641 gcttcgcttt tacccggtga tattctttaa acccttcctt tttcgtcgat tgagcatggg 605701 ctttttccga ccaagaagcg agcccattca tttgtgcttc aatccgttca accatttttt 605761 gctgcttttc atattcacgc tgctgggtga gtcttttctt ctcccggaac ttcatatacc 605821 cggagtaatt ccctttgaat tcaatcagcg tctgatcctc aagcgaccat atttttgttg 605881 cggcttcgtc taaaaaatat cgatcgtgag aaacgagaat cacagtgccg ttataatgtt 605941 tcagctgttg gatgagaaat tgcaagcttt tttcatcaag gtggtttgtc ggttcatcta 606001 acagcagcag atctgcatcc tctgatagtc ctttcgccag ccgcgctttc agtttttcac 606061 cgccgcttaa ctgatgaaaa tcacgaagag gcacatgcca tttctccagt aacttctttt 606121 cggcaggtgt ctgatccgca aaggaatacg ccgcggtttc ctgttcaacc aaagccagtt 606181 ttatatcctt ccgaaggatt tgaccctgtg caggggctaa gtcattgtga atgaggtgca 606241 gcaacgtaga tttcccagcg ccgtttttgc cgataatccc aatgatatct ccttgctgaa 606301 cactggcgtt tacatgttta aaaacagttt gatcctttac ttcatagcta acgtttgtta 606361 atgttacgat ctctttcatc catatccctc gctttaaagg gagaataaaa aaatcctccc 606421 aaatgtgttg gaaggattag ccgtgcctgt gcatgatcaa ataagctatt ttttataaat 606481 agcagtgtcg tatatataga aaatgggcag actaatccta ttttttgatt tgaaatattg 606541 atttcaaacg gtaaaaataa gattagttaa tcattgtcca cccatcatcc cttcttgttt 606601 tgattacaaa cactatagca tacctttaaa ttcaaaagca aaggtcattt tcatcaaaaa 606661 aactcctgct ctcatttttg aggcaggagt tttgagtctt attgatgctt cgcttttctc 606721 actttataaa tcacaatcag caaaataaac caaaccggtg tgacaaataa ggaaacacga 606781 gtatcctgtg ccagtgccag cacaaccaga acaaacgcca ggaacgcaag aatcaggtaa 606841 tttgtaaacg gataaagcgg aagcttaaac ttgtttgttt tcgctaattc aggtcttgtt 606901 ttgcggtatt tcatatggca gatgaccgta atcccccaaa tgtagataaa gcatacggtt 606961 gaaatacttg tgatcagggt gaatacgcct tctggcatga tgtagtttaa cgtaacaccg 607021 attaaaatca cgatagctga aaagaataaa gcatttctag gcactttacg ctgagtcagt 607081 ttcgccattg actcaggcgc attgtgatct ttcgccaggg aatagaccat acggcttgta 607141 ctgaatacag cgctgttgca tgctgaagca gcggatgtca acacaacaaa gttgataata 607201 cttgcagccc cgacgatgcc aacagcgaca aatacttgta cgaatgggct ttcgctggga 607261 ttgatgatat cccaaggata gatgctcata atcacgagaa gagccccgat ataaaaaagc 607321 agcacacgga caggaatatt gttgatcgcc ttagggatta ctttttcagg gttttctgtt 607381 tcaccggccg taagcccgac aagctcaatg ccgacaaaag caaacacaac catctggaac 607441 gagaggataa acccgtgcat gccattcggg aacaggcctc cgtggctcca gaggtttgtg 607501 aagctggaca ctcctgagct tgtggaaaag cctttgaaaa tcatcacaag gccaatgacg 607561 attaacgcca aaatggcaat gactttaatc aaagcgaacc aaaattctaa ttctccaaaa 607621 agcttgactg tcgccagatt cataatcagt aaaataataa gagcgattaa gccaggcacc 607681 cattgcggca cacccgggag ccaatattga gtgtagagcc cgactgctgt cagatcagcc 607741 atcgcaatgg aaatccagca gaaccaatat gtccagccgg tgataaaagc tgccatatcg 607801 cctaggtagt cttgtacaaa atccacaaaa gagtgatagt tcaagtttga taacagcagt 607861 tcacccagcg atctcataat taaaaagcaa atgatccctg tgatcatata agcaaataaa 607921 atcgaaggtc cggcaaaatg aatcgatttg cccgagccga gaaataagcc tgtcccaatg 607981 gctccgccga tggcgatgag ctggatatgc ctgtttttca agcctctctg caacgtttgc 608041 tgatttatat tgtctttcgt catgtcgtct gtcactttat gtgttcctcc attgaaaatt 608101 gtttattgag tcagcaatct atttttaatg attattataa cactaaaatt tctatctttt 608161 ttactaaaaa aggattgatg aaaagaattt taatgtgatt tggactattt cccgaaaaag 608221 cggctccatt tagggagccg cttttttatg ctttttcagt ttttgtcata aacaggtaga 608281 gcccgtaatc tgtcggtgcg gatgcgtagc ctgcctgccg cagcattgct gtgatattgc 608341 cgcggtggta tgtcccgtga ttgacaacgt ggggaagcag ttcggaaaca gttgttttca 608401 tgattccgct tgagggattt tgaatctgga gtggcttatt gagctgttct ttttgctgta 608461 aaaatagtat atagcgctcg gataacctca gaaaaaggtc ttccatttcc tctatttctt 608521 tagcctctgt ctgttcttta agctgttcag ctaaagccaa cgcatcgctc aaggttttgc 608581 cggaaaacac ttcaatccag ccgagatcag aaagataaac atgagacaat acatgggata 608641 ttgacggaaa cacgctttga atttcttgat ggtatatctc ttttggaagc tcttttaatc 608701 ggttgaatat ttgttgattg gcccagacgt tatattcata caatttgaat gcaaaatctg 608761 acatgttaaa attccccctt tcgtgtgtat agctttcatt atacacgaac atgagttctt 608821 atgtagagtg ctcgaaaata aaatttgttg acatatatag tttagaggaa taaactaatt 608881 gacattgaac ataaagttta gcggggtaaa ctataatgag gaggggaaga tattgaatga 608941 acaaaagcta tgtcaggcga taaacctgtt tgtggaagtc ctgcttgaag ggacagaatt 609001 tgtgcatcgt gaaatcaatc aggatgtctt caagcatatc tcaagggaac aggcagacct 609061 gttgaaaatt ttaaaagtca agggcccaac ctctcccggc agcctggcca tgtaccaaaa 609121 tgtacataag agcgcgatct ctaacagact gaaaaagctg ctcgaaaagg gattggttca 609181 atgggacgac tgtccggaaa aaagtgatag gcgctctaag cttattaaca ttacacccag 609241 tggtgaacac atactagaag aattagattc tgccatcttt aacgcgctca aaccgttgat 609301 tgatgatata gatgaggaac acttacattc tatcatcgag atattcacca ttttaaaaag 609361 caaatttaaa ggaggagatt ctgccgaatg agagcaatca tcaaattcaa gtgggcaatt 609421 gcagccatag tattagcact taccgtcgtt ttgagtttgt tttctccgaa cttaacggag 609481 ctggccaatc aaaaggggca ggcccagctt cccgctgatg ctgtttcaga aagggcaaac 609541 gccattttaa aacaagcggg agaagacaat aattcgatca gtgtagtctt tacattagac 609601 aacgctataa agaaagaaac agagaatcag ctccggataa taattgataa aatcaaaaag 609661 atcgacggtg tagaagaggt aacatctcct ctgtcagcgg aaaaagaagt caaagaccag 609721 ttgatgtcga aagacaagaa aaccgttctc atgcctgtca cgattacagg ttctgataaa 609781 aaggcggaaa aaattgcgga cgagatttat caaatcgttc ctgatgactt gacggcatat 609841 attacgggag cttcccttat caaccaggat ttcgctcaca gctcagagga agggcttaag 609901 aaaacggaag tgataacagt ctgcctgatc atcggtttac tgttgatcgt gttccgatct 609961 gttgtgacgc cttttatccc gattgtggtt gtcggttttt cttatctgat cagtcaatct 610021 atactgggca tccttgtata caatgttgat tttcctatct cgacgtttac gcaaaccttc 610081 ttagttgcga tcctgttcgg cattggaaca gattactgca tactgcttct tacacggttc 610141 cgtgaagaat tggcaaacgg gcatgataaa aaagaagcgg cgcttatcgc ttaccgcaca 610201 gggggaaaaa ccttatttat cagcggattt gcggtattga tcggattttc cgccttagga 610261 tttgcgaagt ttgcgatttt ccaatccgca gtaggggtag cagtcggtgt gggaatttta 610321 atgatcatcc tctacacact gctgccatta tttatggtga cgctgggtga aaaattattc 610381 tggccttcta agaaagtgct gtcacacagt gataacaaac tatgggcgtt tctcggcaga 610441 cactccgttg cgcgtccgtt tctgttcatt gtcatcacgg tggtgattac gcttccgttc 610501 atcttgacct atgatgacca gatttcattc gactcaactg cggaaatcag cagcgattat 610561 aaatctataa aagctctcga ggccattaag gatggattcg gggaaggaaa agcgttcccg 610621 atcaatgttg tcgtaaaagg agacaaagat cttacaacag ctgatacaat cccctatcta 610681 ggaaatatca gcaaagcgat cgagaaagtt gatcatgttg actctgttat gaccattacg 610741 cagccgactg gtaaaaaaat caaagattta tatattgata accagctagg atcggtttca 610801 gacgggctgg ataagacggt gaaagggatt gccgatgtcc aaagcggatt aacggatata 610861 gaaaacggac tgaatcaaat ggcagggcaa accggctcgg cctcaaatgg agggtctggc 610921 ggttcactgg gcgatgcggc agatggcttg ggcaaaatca atcagcagct gcagctcgtg 610981 agcaaacaga tttcccaaac cggcaatacc gcacagaccg tgcagcagct tacggcaata 611041 agcggacagc ttggccagat tcaaaccggc cttgaacaag cgaaccaaca gctctcaggc 611101 cagcaggcac aagccggaac gctgacagaa agcctgaaaa agctgtccga aggcgtgaaa 611161 agcgcaaatg agggcctgac gaaagtctct gacggtatta cagcttccag tgatatatta 611221 gaggacatga gcaaaagtcc aactgtaaga gatactggca tattcattcc tgatcaagta 611281 atgaaggaca aagactttaa gaagtcaatt gaccagtatt cctttgcaga cggcaaaggt 611341 gttcaattaa gtgtcgttct ggattcaaat ccgtactcag aacaagctat tacgacaata 611401 aaccaaatca aaaaagctgt cgcaaacgaa gttgacggca ctcctttgga gaatgcacag 611461 atcgtgtacg gcggggtcac gagtatgaat gcggacttaa aggagctatc cacaacggac 611521 ttctccagaa caatggtgat tatgattata ggcctgttta tcgtgttaac cattttgttc 611581 cgctcaatga tcatgccgat ttatatgatc gcgtcattgc tgctgacgta ctatacgtcg 611641 atatccataa cagaattaat ttttgtaaac ggcttaggaa acgcgggtgt cagctgggca 611701 gtgccattct tcagctttgt catcttgatc gcgttagggg tagattattc gatcttcttg 611761 ctggatcgat ttaaggaaga ggtgcacctt ggcattgagc aaggtgtcgt caggtcaatg 611821 agcaaaatgg gatctgtcat tattacagct gccattatat tggccggtac gttcgcggcg 611881 atgatgcctt caggtgtcaa tacactgatg caggtggcaa gtgttatcat catcgggctc 611941 ttgctttacg gccttgtcat acttccgctc ttcatcccgg caatcattgc gacctttgga 612001 gaaggaaact ggtggccgtt cggcaggaag aaaggaaaag agtaatcgag agaagagtga 612061 tgaatggtca tcactctttt ttcatgacta aacgactaac ttcagacgtg ttacccaaaa 612121 agatcagacg atcaaacggc ggctgtactt aaaaacaaag agcccggaaa acattcccgg 612181 gctctttgtt ttatttccat tctgcaattg tatcaatcgg cagacggtag gaagcatagc 612241 cttcgtctgc tgcttttccg atagaaagta gcataaccgg tacataacgt tctttatcta 612301 atccgaaggt ttccgcgatg ttttctttat cgtatccgcc gatcgggttt gtatcgtagc 612361 catgcgcgcg tgcagtcagc atcagctgca tggaaacaag acctccgtca atcaggatcg 612421 tttcacggtt gacctgtgcc ggaagctttt caaaatgtgc ggtcagcgcg gcgatttgtc 612481 tgtctttgac ctcctgcggc atgtaaccaa gttccacggc ttttgaatag atttcttcta 612541 gatagtctgc gttgttcatg tctgcaaata cagcgatgac agcagatgat gttgtgactt 612601 gtgtttggtt aaagcttgca agcggtgcga gcttttcttt tccttccggg ctgtcaatga 612661 caagaaaacg ccatggctgc gcgttaacag aagatggggc agttgttgct tcctctaaga 612721 tctctgtcat ttcttctttg ctgattttta ctgccggatc atagttgcgg atagaacggc 612781 ggcctttcat aatttccata aaatcgtttg ttttgatcat gttgatacac tcctcttaag 612841 cttcgatatt atttatattg tttcgcatgc gcgccagcac atcaatgagc aggcggcgtt 612901 cttctgcgct tacatttgcg agcatttcct tcatgaaacg ctccttttcc ttcttagaag 612961 actcaattcg ctctcttcct tggtctgtta accgaacaag ggtgatgcgg ttgtcctcag 613021 gcttgcgccg ccttgatacc atgcctttgg attccagctg tttcaggtgt ctggtaacgg 613081 ctgcgctatc gatatttact ttcttttgaa ggtcgctttg actgatctca tctgcatgat 613141 aaagcaatgt cagcaattcc aaacgagatt ggctgatgcc cgtgcatgcc tcgaacttca 613201 cgccaatcac cttgttcacg ccttgcagct gatataaaat ctcggcttcc tctgaacaaa 613261 atgacgccaa aacccatccc ttctttcctg tcaaaactat taattgatat atcaatgatt 613321 gacacgtcaa ttaatataca acgattgatt tcatcttgca agccatttgc acttttgaac 613381 aacctcccag cgcataaaat tcgctaggct agaacttagc aaaaaaagct ggccgcttct 613441 tcagatgatg ctggtcacga tgattccctg catcattccc atttataggt gttcggaata 613501 tcactttgcc ggcccgtgct caagcggctt tcacaggctg aaagttatga tacaatatac 613561 aaatgtttca cagcttcaat ccatagttgg agctgacatc cattatataa gggactaggt 613621 tgaagggaag gtttgataac atgctgcaca atccaactgg aaaagaacgc ttggcactag 613681 cgtttctgct cggcatgctt gctatattgg gcccgcttaa tatagatatg tatttgccaa 613741 gttttcctga aatcgcgaaa gatttatcag caagtgcttc acttgttcag ttaagtttaa 613801 cagcctgtct ggtcgggctt acgatcggcc agctgattgt cgggccggtc agcgatgcgc 613861 agggaagacg aaaaccgcta ttaatctgta tttttttatt tgcgttatct tctctgtttt 613921 gtgcactgtc gcccaatata acaactttag tggctgcgcg ttttttacaa ggcttcactg 613981 cttctgcagg gcttgtgctg tctcgcgcaa tcgtccgcga tgtgtttacc ggaagagagc 614041 tttctaaatt tttctcgctg ttaatggtca ttaccgcggt ggcgccaatg gttgcgccta 614101 tgacaggcgg tgccattttg cttttgccgt tcgcaacgtg gcatacaatt tttcacgtct 614161 taatgatcat cggattttta ctagttcttc tgattgcatt gaggttaaaa gaaacgcttc 614221 cgctggaaaa acggattcca agctcaatcg gaacatccgt caaaacgatg ggcagcctgc 614281 tgaaggatcg atcctttatg gggtacgcgt taactgtcgg atttattcac gggggaagct 614341 ttgcatatgt gtctggtacg ccttttgtat accaggatat ctacggggtg tctccgcagg 614401 tatttagtat tctttttggc attaacgggc tggcgattat atcgggcagc tttatcatcg 614461 gacgctttgg cggaatcatt catgaaaaaa gcctgcttcg tatagcggtc attacggcta 614521 tgattgcgac ggctgtgcta ttaaccatga ccatgattca cggtcctctt gctacattag 614581 tcatatccat tttcatttac atgattacga tcggcatggt tctgaccagc acgtttaccc 614641 tagccatgga aaagcagggg caccgcgccg gaagtgcaag tgcgctgctt ggaatgcttc 614701 cgctgctcct cggttcaatc gtgtcaccgc ttgtaggcat taatgagaca acagccgttc 614761 cgatgggagc catcatgttt gtgacagctg tcatcggctc actggcgttt tttggattaa 614821 cgaaagaacg agtagggcag aattcataaa aaaacctgac atgacgtcag gttttttgtt 614881 ttatttagaa taacaacagc aggcctgcaa tcgccggagt caaaaagatg gctgatttca 614941 aaaccacctt tggcatgagg ttggtgaatt tcgcgcctac ataggccccg cacattgtcc 615001 cgaccagaac tttgacaagt aaaacgtaat caacaaaacc ttctgtaata tatccgatgc 615061 ctccacctac agccagaggg atgatcacaa gcatcgtcgt tccgacagaa tggcgaatgg 615121 acagattcag cataatcatt aaaccgattt gaataaaagg tgccgacccg atgccgaatg 615181 tgccggaaag aacgccggct gcaattccta agatgaccgc tctcgtatac gttgaaagag 615241 tgctttgatt cacttgagcc ttctctttta aaataaataa tctgattaaa atgagaattg 615301 ctgataaaaa taacattcca gccgtcaaat aatgaagcaa atcagccgga ataaaagaag 615361 tcagcttggc gccgaaaaat gagccaaccg cagcaaagcc tccgactatt aagccgattt 615421 tcatttgaat gttaccctcg cgatagtggc tgtatgcccc tgataagctt gtaaaagcca 615481 tgccggcaag cgaagtgcct aaagccgtat gaatcgggat atggaaaaga agcgttaaaa 615541 gggcaatgac aaagccggct ccaccggcgc caataaagcc taaaataatt cctagaagaa 615601 acataacaag aataatgagc atattttttc ctccattgaa aagatgtaaa aatgtaatcg 615661 tgcgctattc tggcggaggt atggtgtcct attgacgaag aaaaacacgc cgttttttca 615721 gttgccagta gtccgtcgac cgtcgttcag caaacatatc gtacctcaaa ttcagggatc 615781 tgacaaggca gtttgttgct tcccattacc atctgttata tgattttgat gaagaaaagc 615841 ccttgaatat attcaaaaga ggtattatat atggacgatt ttaaattaga taagccgact 615901 ccctactacc tgcaatttta taaccagcta aaaaaaatga tcttcaacgg gacttttaag 615961 cctggggaac ggataaacga aacacagctg gcgaaaagct ttggcgtcag ccgctctccg 616021 ataagggaag ccatgcgatt gcttgagaaa gatggtttgt taaaagcgga tgaccgaaat 616081 gggttttcga tcacgtcgtt aacggcaaaa gatgtagatg agatttataa aatcagaatt 616141 ccgctggagc agctggcagt cgaattagtc atagacgaag cggacgaaga agagctgacc 616201 atactcgaaa aacagcttga agaaacagag aaagcgattc acaacggcac ggaagataca 616261 gaaatcattc gtttaaacca aaaatttcat gagctgctgg ttgatttcag ccataacaga 616321 catttgaaaa atttgcttga gcatgtaaat gacctgattc atttttgcag aatccttaat 616381 tataccggcg accaccgcgc agaaacgata ctgcgtgagc accgcaggat atttgaagaa 616441 gtgaaaaaga aaaacaaaga agcagccaaa caacatgtgc tggctcattt caatcatgac 616501 tgtgagcatt tgaagcatgt gcttgaagaa ggtaaagaga attgatttgt atgatccggt 616561 accaagggag agcagaaccc ttggtatttt tttatgtatt caccacatat ctaagaggcc 616621 ccgttaataa gattttatga tggtttgact aacgaataat gggggttaaa tatgtttatc 616681 catatcgtcg ggcctggtga ttctttgttt tcgataggca gaagatacgg tgcttctgtt 616741 gatcaaatac ggggtgtgaa tggtttagat gaaacgaata tcgtgccggg gcaggctctg 616801 cttatccctc tttatgtata tacagtccag ccgagagata cgcttaccgc cattgcagct 616861 aaagcgtttg tgccattaga gcgactgcga gcggccaatc cgggcatcag cccaaatgct 616921 ttacaagcgg gagcaaaaat aacgattcct tcgatctcaa attacattgc gggaacgtta 616981 agtttttatg tgctccgaaa cccagacctc gatcgggaat taatcaatga ttatgcgcca 617041 tactcgtctt cgatttcaat tttcgaatac catattgcac cgaacggcga cattgcaaac 617101 caattgaatg atgcggccgc tattgagaca acttggcaaa gacgagtcac gccgctggca 617161 acaataacga accttacatc aggaggcttc agtacggaga ttgttcacca agtgctaaac 617221 aatccgacag cgagaaccaa tctggtcaac aacatttatg acttagtttc cacaagggga 617281 tatggcggtg tcacaatcga ttttgagcag gtgagcgccg cggatcgcga tcttttcact 617341 ggatttttac gccagctgag agatcgactt caggcgggag ggtatgtgct gacgatagct 617401 gttcctgcaa aaacaagtga taatatccca tggctgaggg gctacgatta cggggggata 617461 ggagcggttg tcaattatat gtttatcatg gcttatgatt ggcatcatgc gggaagtgag 617521 ccgggtcctg tagcgccgat tactgaaata aggagaacca ttgagtttac gattgcgcag 617581 gtgccgagca gaaaaatcat tatcggagtc ccgctctacg ggtacgactg gatcatcccg 617641 taccagccgg gcacagttgc ttcagcgatt tcaaatcaaa acgcaatcga aagagcgatg 617701 aggtaccaag ccccgataca atattcagcc gaatatcaat caccgttttt ccggtacagt 617761 gatcagcagg ggcggacgca tgaggtatgg tttgaggatg tcagaagcat gagccggaag 617821 atgcagatcg tccgtgaata cagattgcag gctattggcg cttggcagtt aacgctgggc 617881 tttacgccgg gcccatggct tctgcggaaa ttttttacga tcagaaaagt gtaaaaaaag 617941 acaccagagc ttgggtgtct tttttttgat taagtccaga gcagcagaat agttcattca 618001 tttgtacctt gcatgggttg tgttcccatt ttacgattag tagtagtctg atcaaacaaa 618061 gagtcagaat acgatttgag agggagttgt ctacatgaag acagtattga ttttgaattt 618121 tcctgcggaa ggccatgtga atcctacttt aggcattacg aaagcgtttt ccgataaggg 618181 atatgatgtc cattatatat ccactgaaaa atataaaaaa cgattagaag cagcgggagc 618241 aacggtccat cttcaccggg atctgctgcg aacgacacct attcatgtcg gttcgcccaa 618301 tggcattctt gatttcgtga aaatccatat caaaacgtca ttggacattt tacagattgt 618361 caaagactta tctaagagca ttcaatttga ttttgtttat tatgataaat tcggcgcggg 618421 ggaattggtg agggattact tagatattcc aggggtctct tcatcggcgt ctttcctgtt 618481 tggcgaggag catctgaaaa tcctgccgct gcatccggag tctggagcgc cgcttgaatt 618541 ggatcaagag tgcgaagacc ttttggcaaa aatgaaagaa acgtacggtg ttgccccgaa 618601 aaacctggtt caattcatga acaataaagg ggaattgaac gtagtgtata caagccgtta 618661 ttttcagcca gaaagtgatc gtttcgggga tgaatgtcta tttatcgggc cgagctttcc 618721 aaagagagcg gaaaaaacag atttcccgat tgaacagcta aaagatgaga aggtcattta 618781 tatttcaatg gggactgtac tggatcatac agaggatttc ttcaaccttt gtattgatgc 618841 attttcaggc tttaacggaa aagtcgtcat cgctgccgga gaaaaagcgg acctgaccaa 618901 attaaagcag gcgccggaaa actttatcat tgctccgtat gtccctcagc tggaagtgct 618961 ggagcaatcg gatgttttca ttacacacgg cggaatgaac agcgtaaacg aaggcattca 619021 tttcagcgtg ccactggttg tcatgcctca tgacaaggat cagccgatgg tggcgcagcg 619081 tctctctgaa ctccatgcag gctatgtcat ctctaaagat gaagtcaatg cccaaatatt 619141 aaaacaggcc gtagatgagg ttttgcgcaa cgatcagtat acggcaggca ttaaaaaaat 619201 caatcaaagc ttcaaagaat gtatggacat ggaagaagtg atggagcgga ttgatgagtt 619261 gattcgccaa aaaaacaaat aagaaaaaga actcccgtac cttgtacggg agttcttgat 619321 ttaaaacttg attttgattt tttgagcatc actgattttc ttatggttat ggtcaaagac 619381 gtcacttgtc gtgatttcga tccacttgat ctcttttgtt ttcttctcag catccgcggc 619441 cttatcatga gcatggccgc ttgatgcgtt cacaataaag ccgagatttc cggacttttc 619501 ggcgccgcct tccaattcgc cgtttaactc ttcaagataa atatctttgt tccaatcaaa 619561 ggtttcaccc gtatttgttt tcatcaatgc aatcggcgca acatttactt tttttgtaga 619621 ggtgttcttg atatcaacga aaaccttaac gaaatcaaac tcttcatcgt gtgttaactc 619681 atgaaagtaa tcaatcatgc tgtagtccgg gcgcaagtgg atcagcttca tttcttttac 619741 tgttaactcc acgtcgccaa ttttataggt tttgttcact tgtttgatat cttttaagac 619801 agcttttcct ttatcatctg aaaacgtttg gccgacctta tgcaatgtcc ggtcatcagt 619861 tacctgggaa ttaggctgat aatcatctgt gctgtccttc tgggatgaag tgctttgcgg 619921 ctcagctttt actgttttct ccccgcctgc atgctgtttt tcagtactgg cgtttgatga 619981 gcagcccgca agcatgatag caaaaacgag aattgaaaga attcttctca tgatgattcc 620041 tccattaaaa agagatcccg ttacttcata caagcaacgg gacaccttgt attcttttac 620101 ttatcgttaa tcttaatgtt gtattgtaaa gccttgaaaa catttttggc gatttctgta 620161 ttgtcgattt ggccggcaaa tgtctcacta gacggaccgt atgcatagac gggaacatct 620221 tcaccggtat gtccgcctgt tgtccatcca gtgtgagagc gtttattaaa gatgttctcg 620281 attgcgttat cgatatccag tacttccttc gattttgccg cttcttcaac agattgaatt 620341 tcggcttttg ttaaagccaa tttcttttga tcgatatatg ttttcaacgt tttttcaaca 620401 tccgcgccgt cagcgatctt ttctgccata aagtctggtg tgcgctttgc ggctttaatg 620461 ggttcactga accagttgta gatgccgtcc gcaccgatgg aatatccgcc ggttgagtgg 620521 tcagccgttg cgacaaccaa tgtgtgcttg tcttttttag cgaaatcaat agccgcctta 620581 taagcttgtt cgaagtcttc catctcgctc atggcgccaa cgatatcatt gtcatggccc 620641 gcccagtcaa tctggctgcc ttccaccatg aggaagaatc cgtctttatc cttgtttaat 620701 tttttaatgg ctgtgtttgt catatcttta agtgatggaa tatccttcgt acggtcaatc 620761 tttttaggca ggccgccgtc agcgaatagg ccgagaactt ggctgtcttt gtttttcagc 620821 atgtccttgc gatcatccac gtagctgtac cccgcctttt tgaattcctt aatcaaatta 620881 cggtccttac ggtcaaaatt gctctttcct ccgcctagaa ggacatcaat tttgtgcttg 620941 ccgttgacca tctcatcaaa ataatcatcc gcaattgagt tcatattttt tcggctgtgg 621001 tcgtgtgaac caaaagaggc cggagtggcg tgtgtaattt ctgaagtggc cacaagtcct 621061 gttgcttttc ctttttcttt cgcagcttca agcaccgttt tggcttctga cccgtcgtta 621121 tcaacggcta tggcattatt gtatgtttta attcccgcag acatagccgt tgccgccgct 621181 gcagaatccg ttacattttg ttcaggatca tcggggtaag ttgtttgctg gccgacaaga 621241 tactgatcaa aagccgtagg ctccacaact tttgtctttt tattatcctt taagtatcga 621301 taagcagacg tataagacac acccatacca tcaccaatca gaacaataac atttttaatt 621361 tcgtcttggt tccccttttt cttttcctgg gcgctggctt caggcacact gccgctggct 621421 aagctgctga acgcaattga tgataaaacc gcgataggca gtaatttctt cgggaatttt 621481 ttcaactgga taacctccta aatatagatg aatctcaatg acaacccaat tatattttta 621541 aactgttaag ctagtattaa tcgattttaa agattggatt tacaagaata atgaactggc 621601 acccttaaat aatggttatt cttttatgag aagttttaga aggaaagagc gatagtacta 621661 aagaaataaa ttggaggaat agatactggc cgtggatagg cggactgaaa tctgctatag 621721 tcgcatagaa gcaacccgct tacatcttga acaatttaaa gtattacgtt ggaaagaggt 621781 attgtgtaag cacatgtctg agcagttcat atggagtggc atcattttat tttaggaggg 621841 aacaacatgg acgttttttc tgagtactta gcggggattg ctgacccgtt ccaccgagaa 621901 agaacggaag aggtgttaac ttggataaaa aataaatatc caaatttaca tacagaaata 621961 aaatggaatc agccgatgtt tacggatcac ggtacattta ttattggctt tagtgtttct 622021 aaaaagcatt tagctgtcgc tcctgaaaaa gtaacgatag cgcacgtaga ggatgatatt 622081 gtgaaggccg gatatgatta caccgagcag ctgatacgta tcccttggaa cggtccagtt 622141 gattatacgc tacttgagaa aatgattgag tttaatattc tggacaaggc ggactgctcc 622201 actttttggc ggaaatgaag aaaaaggcat aacatatgag ctgtataaaa tatgttacgc 622261 cttttcattt gtctattttt cgttttgatc atctattgct gcttttcatc aaacaaggtc 622321 ttttcattga gcgtaagctg actcgcagaa taatgattac cttgtttcca tttcacttca 622381 atcgtaatat catggccttc aagctcatgt tcatctaacc gctctaaaaa agaaacggac 622441 ttttcttttg cgcttccatc agaaaaagtg cctccagcat aatcatgcat cgggatttcc 622501 gtgtcagaac tcagcagaac ttcatcatcc ttttttacaa tcagtgattc cagataagtg 622561 ttgtctattt caattgtatc accgatccaa taaagtttgc cgctgtattc attcggtgca 622621 tcttcatttt ttgtgaaaac agcttcccaa ttctgatctt tgctttctcc ctgccaattt 622681 ggatactcca aacgaacatg atgaatcagg tgataggaaa aaaagatcaa gcagaaagcg 622741 attaatagga atgccgtgaa aatgagaggg tatttataat gactggacat aaaagactcc 622801 tattcgttta atcaattacc ttcgaaaata gaatttcatc ccgaatcaaa atgccgtttt 622861 cagccacctc gggaatctcc ggcttgagtc ggcgcgcttt ttcaactgcg ttcggaaaca 622921 ctgcggcgaa ttgatagcct ctcttttgat aaaacgctat cgcatttaca ttatcattcg 622981 ttgtgataag ctttattcgt tgacaatgtg catgtttagc cttctcttca acctgctgaa 623041 gtaaagctgt gccgattcct ttattttcaa tcatactatc taatgaaata atttcacaat 623101 ctttcccatc tattgtgtat gtaatacagc caatgatttc gccgctttca tttactgcgg 623161 caaatccatc taattcatca caccgaaaaa tgccgctgga aatcgccatc tcgggtgtac 623221 cccaatgctt ggcaaaaaaa tcggtcaaca tatgtttcgc tatctcattg tttgggatga 623281 tgatcatcat aacactcctc tattgaaaga ttgcatatgt actatcaata taaacaatat 623341 ataacaaaaa aaatagatgt tgaggtgacg gcatggaaat cagcgatatc atttacgggc 623401 agcaccatat agacggagtg ctggaagagc ttatcaaaag cgctcctgtg caaagattaa 623461 aaggaatcta tcaaggcgga gcaagctttt tagtcaatcg aaagtggaat gtgaccaggt 623521 atgagcactc catcggcgtg atgctcctca tcaaaaagct cggaggaacg atagaagaac 623581 agattgcggg tctgctccac gacgtatcac acacagcttt ttctcatgtg gtcgacgttg 623641 tctttgaaaa tcaagcagaa gactatcatg aaaacatctt tcaacaagtc attgttcact 623701 ctgaaatccc ggacatttta caaaaacacg gctatcatac tgaagaactt ttatctgacg 623761 attcaaggtg gacattgctc gaacagcccg caccggagct gtgtgctgat cggacagact 623821 atacgctgcg tgatatgtac cgatatggac acattaacct gcacgaagcg caaacctttt 623881 tggatcatct tattgtgaga aacggaagga tgtttcctga tagtattgaa gccgccgaat 623941 ggtttgtcag tgtgtactac aaggaagtaa ttgatttctt tttgaatcct gtgaatgtat 624001 atggatatga atatttagcg cgagcattga aggcagcgct gcggcatgat gtcatatctg 624061 cagaggatct gctgaaaacg gaccaagagg tactgaacat cctgcgtgca tcaaaaaatg 624121 aagaagtcct gagcttgctt acatccattc atcccggcat acaagtaata gaggatgaca 624181 tccagtacga tttccatcaa aagaagaaaa tgcgcctaat cgatccatcc atttttcttg 624241 atgacaaatg gatcaaatcc tcaggtgttt ctgaaaaggt gaggaaaatg ggtgaggccg 624301 cttatcaaaa agcaaaaaaa ggtgtgtata taaaaatctt aaagcagtaa ttgccgcctg 624361 acagcggctt tttttatgtt tggctttgca aacaaagggg aataggacaa actgcgggaa 624421 cgctttatga gaatatcagc gtatttacat accgttcggg ggtatagtat tatcgagagg 624481 gcatgttttc attgtctgcg ggcaaaagtt acaggaaaaa aatgaagcaa aggagaatga 624541 acatgaaaat ctctaaatat gcactgggaa ttctgatgtt atctctagtt tttgttttat 624601 cagcatgcgg caataacaac agtacgaaag aaagcacaca tgacaatcat tcagactcct 624661 caacacatga agagatggac cattccggat cagctgacgt tccagaggga ttacaggaat 624721 ctaaaaatcc gaaatacaaa gtaggcagcc aagtaatcat caatacttct catatgaaag 624781 gcatgaaagg tgctgaagct acggtaacag gcgcctatga tacaacggcg tatgttgttt 624841 cttatactcc gactaatggg ggacagcgtg tggatcatca caaatgggtg atccaagaag 624901 aaatcaaaga tgccggagat aaaacgttac aacccggaga tcaggtgatt ttagaggctt 624961 ctcatatgaa aggcatgaaa ggagcaacag ccgagatcga ttccgcggaa aaaacaactg 625021 tatacatggt tgactacaca tcgacaacga gcggcgaaaa agtgaaaaac cacaaatggg 625081 tcacagaaga tgagctttca gctaaataat aaaaaatcct ccttttacaa ggaggatttt 625141 tttgctgttt gaacaggtct tgttaaagaa atgaaagcaa acaggacagc gatgatcaca 625201 atcgatccgc cgcaccatgc cgttgacacc acagtacccg tctgatccaa aacaacaccg 625261 ccaatggctg agccaagggc aattccgact tggagggccg atgtgttaaa gctttgctga 625321 atgtcagacg aatcaggtgc aatttcaatt aaatagcttt gctgagccgg ggcgaggctc 625381 cagctcagaa gaccccaaat caccatgaca ggcaaaaaga aaatcataga cgatgtagac 625441 agcggcagta agaacataat gatggcaaag gaaccggtca ccagcaaaat gctcttaaag 625501 gaaccaagcc ggtcagatag cgctcctccg aaagggcctc cgcatacagc agatatcccg 625561 aaaaggaaat aacaaatgct gacccagaaa gagctcaggt gaagagtctc ttctaaaaac 625621 ggcgcaaagt aagcgtaaag cgtgtagtgg ccagctaatg taaacatcgt gacgaggtgt 625681 gaactcgcga ttttcagatt accgatcgtc ttgagttgtt cccggaaagg aatcattttc 625741 tccgccggta ttctttcaaa gaagattgaa ataatcagca tggagatcag tgccaacagg 625801 ccgatgccaa ggaacaaaat ccgccacccg aaggaatcgc tgattaagat tccgagcggc 625861 acgcctaatg cgatagcaga gctgaatccc ataaaaataa ttccgattgc gcgggctctg 625921 tattcaggcg ctacaatttt cggggcaatt gttaaagaaa gcacaacaat cagccctgta 625981 ctcattgctg ccaataccct agataccatc agtgttgcga aattagggct gaaataggcg 626041 acaagattgc taaggaagaa aacaaataaa gcaattagat ataagcgctt ccgctcaatc 626101 ttcgcagtca atgccaaaag cagcggccca gatactgcat atcccagcgc aaacacactg 626161 atcagctgtc cggctgaaac aatggaaatg tctaaatcat ttgcgatctg aggaagaatt 626221 ccccccacaa ttaactcaac caatccgact gcaatcgtag aagctgcaag caggaaaact 626281 ttgaaattca taacaaactc ctttacttaa atgttttgat aaataaaaaa aatcctgatt 626341 acaaaaaatg tcataaacaa attttgtaat caggatttta cggttcctgg tagacaccct 626401 caaaccatat tattgaggtt atacaagtga taatagctat ttaattgatt cgtttccgtt 626461 gatgagtgta ccacattatg aatgaatctt ccatagaaaa atttataaaa cggtgaaccg 626521 gaaaaaaata tgattatatt tattttataa aagtatagac atttaaaatt aaatgactat 626581 aataatcaat gtaagcgttt taataacagg ggggatagca gttgaaaaaa atattactcg 626641 cgtgcagttc aggaatgtct accagtttat tggtgacaaa aatgaaggaa tacgcacagt 626701 ctatcggtga ggaagcggag atttgggctg ttggccagga taaagcaaaa gaagacatga 626761 gaaaagcgga tgccgttttg atcggtccgc aaatgagctt tctgaaaagc gagctccaaa 626821 aagaagcaga tcaatacaac attcaagttg aagtcattga catgatggcc tacggaatgg 626881 cagatgggaa aaaagcgtat gagcaggcat tgtccttaat ggtgaatcaa taatggaaca 626941 gatgaaaatc acgaatttaa cagacgagca aatcagtttt cagctaatcc tgcacagcgg 627001 aaatgcccgc agctgcatca tacaatcact gcgcgcctat aaagaaggga aaaaggacga 627061 ggctgatgcc ctcattgcca aggcggagca ggatttatcc gcggcccatg acattcactt 627121 tcaaatgata cagaaggaat ccggcggaga agcaacagct ttttcattgc tgcttatgca 627181 tgcagaggat catctgatgt caacattatc catgaaagaa ttagtgaaag agatgcttga 627241 tctctttaaa accaagaata tataaaaaat cggggtggat agggtgttcg agaaaatcag 627301 ccaattcctt gttccaattg cagggaggtt aaacaataac cgctatttgc aagtgttgcg 627361 tgatgcattt atgctggctt tcccgctgac gatattcggg tccatttttg tcgtgttaac 627421 gaatttgccg tttctaaaca aaatcatgaa cgcctcaatg cttacgtcgt ttcagtctca 627481 tttcggcatt gcctccacgg cgacaatggg cattatgtct gtctttgttg tgttcgggat 627541 aggctattac ctgtcgaaaa gctatcaggt cgaagctgta tttggcggag cgatcgcttt 627601 ggtttccttt ttgctcttaa cgccatttat cattcagccg gaaacaggtg atgccattac 627661 aggggttatc ccggtcgatc gtctcggtgc aaaagggatg tttcttggga tgattacggc 627721 atttctttct ggcgaaattt acagaagaat cgttcaaaaa aacctgacaa tcaaaatgcc 627781 agccggcgtt ccgcctgctg tagcaaaatc attcgccgca cttattccgg cttttatcac 627841 attgactgta tttttgctga ttaacgtaat ggtgactctg ttttttaaaa caaatatgca 627901 cgacgtcatt tatcatgcga ttcaggctcc gcttgtcgga cttggaagcg gtatcattcc 627961 aacactgatt gccgtgtttt tcattcaaat tctttggttt ttcggactgc atggacagat 628021 cattatcaac tccgtgatgg acccgatttg gaatacactg caggtagaaa acctttctgc 628081 ttacacggcg ggaaaagaaa tccctcatat tatttcaaaa ccgtttatgg agatttatac 628141 agtagggatg ggcggaacag ggatgacgct tgcgattgtg tttaccattc tcatattcat 628201 gaaaagcagg cagatgaagc aagtatcaaa acttggcctc gctcccggta tttttaacgt 628261 aaacgaaccg attatctttg ggcttccgat tgtcatgaat ccgatcatta ttgtgccttg 628321 ggtgctggca ccgatggttg ttacgctcgt cacctatctg gctatgtcag ccgggctcgt 628381 tccgcctcca actggtgtga cagtgccgtg gacggttcca ttattcatta atggcatcat 628441 ggcgacgaac tcaatcatgg ggggcgtgat gcagcttatc aatctgctga ttgtcttcgt 628501 gatctggttt ccgttcctaa aagcaatgga taaattaaat ctggcaaaag aaaaagaaca 628561 ggctgtgcag gagacagctg ctcagcaaaa tgataacagc ataaaaatgt gacataaggg 628621 gagagagact tggcacatac agaacaatat cgttttccaa aggatttttg gtggggatca 628681 tccgcttcag caacacaaat ggagggtgcc gccgacagag acggaaaagg ccagaatata 628741 tgggattatt ggtttgaaaa agaaccgcat cgtttttttg atcatgtcgg acccgcagac 628801 acatcccaat tttacgacaa ctataaagaa gatatcaggc tgatgaagga acttggccac 628861 aactcgttcc ggatgtcgat ttcctggtca cgtttaatac caaacggaac gggcgagatc 628921 aacgataaag ccgcagattt ctataacaat gtcattgatg agctgatcgc taacggaatt 628981 gaaccttttg tcaatttgtt tcatttcgat atgccgatgg cgcttcaaaa aatcggcggc 629041 tgggtcaaca gagagacggt tgacgcgtat gaaaactatg caagaacttg cttccgtttg 629101 tttggcggcc gggtgaaaaa atggttcacg cataatgaac caatcgttcc cgtagaaggc 629161 ggatacctat atgattttca ttatccaaac aaggtcgatt ttaaagaggc cgtccaggtt 629221 ggatttcata cgatgctatc aagtgcccgc gccattcagg cttacaggga gatgaagcag 629281 gacggaaaaa tcggcatcat cttaaatttg accccttcat acccgagaag cagccatccg 629341 gcggatgtga aagccgggga aatcgcagac gcgtttttta acagatcttt tttagaccca 629401 tctgtcaaag gcgaatttcc caaagagctg gttgacattt tgaagcatga aggctttatg 629461 cctgattaca acgctgaaga tctcgacatc atcaaaaaga acacggttga cctgttggga 629521 gtgaattatt accagccgag acgtgtgaaa gcgaaagaac atcttccgaa tcccgacgct 629581 ccttttttgc cggacaggta ttttgatccc tacgtcatgc cgggccgcaa aatgaatccg 629641 catcgcggct gggagatcta tgaaaaaggc gtttatgata ttttgatcaa tttaaaagaa 629701 aactacggca acatcgagtg ttttatctct gaaaacggta tgggggttga aggtgaagag 629761 cgattcaggg atgaacaagg catcattcag gatgattacc ggattgaatt tataaaagag 629821 cacctcaaat ggattcaccg cgccatacag gaaggctcga acgtaaaagg ctatcactta 629881 tggacgttca tggacaactg gtcttggaca aatgcctata aaaaccgata cggatttgta 629941 tcagtcaatc ttgagaaaga cggagaaaga accgtcaaaa agagcggaaa atggttcaaa 630001 gaggttgctg agcatagcgg tttctagatt ttcctaaagg tcaagatctt ccggcaatca 630061 tcataacgaa tagagatgac gaaaatccgc aacattgatg aaatagggaa aagaacttat 630121 gatatccgta aaagcttatg tgatatcaaa cagctgccgg aggataccaa tgaataaata 630181 cgaaatcatt gcaaatgaaa tgagaaatag aattaaaaat aacgtatatc cgatcgatca 630241 gcccattcct gatgaagtat ctcttgcaaa agaatttaac tcaagccgca tgacgatgaa 630301 gagagccttg gataatttag ttgccgaggg tctgctgttt agaaaacgag gccatggcac 630361 gtttattatt caatctgcaa tacaggatga ccatgtccat gtagtcagca atgagattct 630421 cggattgacc aacttgctga aagataaaaa aatcaaaagc aaggtcattc agtttgaagt 630481 gcaatttccc actgaggaag tggccgccca tttgtctatt gatcagaaaa caccggttta 630541 ttatgtcgtt cggctgcgaa ttgtagaagg tgaaccctat gtattagaaa aaacatatat 630601 gccgactcat ttaataccgg gcattaatga cgatgtcctt catgattcga tctacaatca 630661 tattacaaat gtgctgcagc tcaaaatcgc cggaacgcat cggaaaatca gagcctgcaa 630721 atctgatcat attgaccagc agcatctggg ctgtaaacag gatgatccaa ttcttgaagt 630781 ggaacatgtg ggcttcttag ataccgggat tccatttgaa tattcctttt cacgtcatcg 630841 gcatgacaag tttgttgtga cttctgtaaa catacggcgc tgattgcgga gacaacaagg 630901 aggccatctg catgcttggc ggtattgaag caggcggcac aaagtttgtt tgtgctgtcg 630961 gtagagaaga tggaacgatc attgacagga tagaattccc cacaaagatg ccggatgaaa 631021 cgatagagaa agtaattcaa tattttagcc aattttcatt acaggcaatc ggcatcggct 631081 cctttggtcc cgttgataac gataaaacca gtcaaacata cggtaccatt acggccacgc 631141 cgaaagcggg ctggagacac tatccctttt tgcaaaccgt taagaacgaa atgaagatcc 631201 cagtcggatt tagtacagat gtcaacgctg cggcgctggg tgaattcctt ttcggtgaag 631261 cgaagggtct tgacagctgc ctgtatataa cgattggcac tggcatcgga gcgggggcta 631321 ttgtagaggg gaggctcctt caggggctgt cacacccaga gatgggccat atttatatcc 631381 ggaggcaccc ggatgacgta taccaaggga agtgccctta tcatggagat tgctttgaag 631441 gcttagcttc aggccccgct atcgaagccc gctgggggaa aaaagccgcg gatttatcag 631501 atatagcaca agtctgggaa ctggaagggt actatattgc ccaagcactg gctcagtata 631561 ttttgatcct tgcacctaaa aaaatcattc ttggcggcgg cgtcatgcaa cagaaacaag 631621 tgttttctta tatctatcaa tatgtaccaa aaatcatgaa cagctactta gatttttctg 631681 aattatcaga tgatataagt gattatattg tacctccacg tttaggcagt aacgccggaa 631741 tcatcggcac gctagtttta gcgcatcagg ccttacaagc agaggcagca tccggggagg 631801 tgcgatcatg acgcatccat tatttttaga gcctgtcttt aaagaaagac tatggggagg 631861 gacgaagctt cgtgacgctt ttggctacgc aataccctca caaaaaacag gtgagtgctg 631921 ggccgtttct gcacatgccc atggctcgtc gtctgtaaaa aatggcccgc tggcaggaaa 631981 gacacttgat caagtatgga aagatcatcc agagatattc gggtttccgg atggtaaggt 632041 gtttccgctg ctggtaaagc tgctggacgc caatatggat ctctccgtgc aagtccatcc 632101 tgatgatgat tatgcaaaac tgcacgaaaa tggcgacctt ggtaaaacgg agtgctggta 632161 tatcattgat tgcaaagatg acgccgaact aattttggga catcatgcaa gcacaaagga 632221 agagttcaaa caacgaatag aaagcggtga ttggaacggg ctgctgaggc gaatcaaaat 632281 caagccagga gatttctttt atgtgccaag cggtacactc catgctttat gtaagggaac 632341 ccttgtcctt gaaatccagc aaaactctga tacaacatat cgcgtatacg attatgaccg 632401 ctgtaatgac cagggccaaa aaagaactct tcatatagaa aaagccatgg aagtcataac 632461 gataccgcat atcgataaag tgcatacacc ggaagtaaaa gaagttggta acgctgagat 632521 cattgtttat gtgcaatcag attatttctc agtgtacaaa tggaagatta gcggccgagc 632581 tgcttttcct tcatatcaaa cctatttgct ggggagtgtt ctgagcggat caggacgaat 632641 cataaataat ggtattcagt atgaatgcaa tgcaggctca cactttattc tgcctgcgca 632701 ttttggagaa tttacaatag aaggaacatg tgaattcatg atatctcatc cttaatgaat 632761 gggggagttg catttgttta agaaacatac gatctctttg ctcattatat ttttacttgc 632821 gtctgctgtt ttagcaaaac caattgaagc gcatactgtg tcgcctgtga atcctaatgc 632881 ccagcagaca acaaaaacag tgatgaactg gcttgcgcac ctgccgaacc gaacggaaaa 632941 cagagtcctt tccggagcgt tcggaggtta cagccatgac acattttcta tggctgaggc 633001 tgatagaatc cgaagcgcca ccgggcaatc gcctgctatt tatggctgcg attatgccag 633061 aggatggctt gaaacagcaa atattgaaga ttcaatagat gtaagctgca acggcgattt 633121 aatgtcgtat tggaaaaatg gcggaattcc gcaaatcagt ttgcacctgg cgaaccctgc 633181 ttttcagtca gggcatttta aaacaccgat tacaaatgat cagtataaaa aaatactaga 633241 ttcttcaaca gtagaaggaa agcggctaaa tgccatgctc agcaaaattg ctgacggact 633301 tcaagagttg gagaaccaag gtgtgcctgt tctgttcagg ccgctgcatg aaatgaacgg 633361 cgaatggttt tggtggggac tcacatcata taaccaaaag gataatgaaa gaatctctct 633421 atataaacag ctctacaaga aaatctatca ttatatgacc gacacaagag gacttgatca 633481 tttgatttgg gtttactctc ccgacgccaa ccgagatttt aaaactgatt tttacccggg 633541 cgcgtcttac gtggatattg tcggattaga tgcgtatttt caagatgcct actcgatcaa 633601 tggatacgat cagctaacag cgcttaataa accatttgct tttacagaag tcggcccgca 633661 aacagcaaac ggcagcttcg attacagcct gttcatcaat gcaataaaac aaaaatatcc 633721 taaaaccatt tactttctgg catggaatga tgaatggagc gcagcagtaa acaagggtgc 633781 ttcagcttta tatcatgaca gctggacact caacaaggga gaaatatgga atggtgattc 633841 tttaacgcca atcgttgagt gaatccgtaa tgtcacaatt aagaaggtgc tcaagaagtt 633901 tcttgagcac cttcccactg gattaagcat tcatatcgcc taacccagga ctgtgttcat 633961 ttggtatttc aggaagcact ggtacgggaa accctgccgg aggatctatt acttgtaact 634021 ctccgccatt tcggcttgga gatttccctt gatagatttc actgattctc gtttcatcca 634081 acctaaagtt aaaatgtgta ttatggtagc ctaattcgac atactttctg cactcaggat 634141 atttattaat gtcataattc ggcacaggga gcagcttcgc ccattcaacg cccaatgtct 634201 cgagcgcttt cgcgaatgca ttctggtgag cattgtcgcg tacaatcaga aaagcaagtg 634261 tttcgcggaa cgtctgatta gagctcattt cataaattct tgttttttgc agcacacctg 634321 tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg ttatacaccc 634381 acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc gctccaataa 634441 tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga tctgtacctt 634501 gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg ttttgaacca 634561 gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg tactgtttct 634621 gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca tttctccgta 634681 atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct tgtccggttt 634741 aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt cttcttaaga 634801 gattttctta tattatttgt aagatgagat aaaatatata catgataagc atgggaaggc 634861 gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac aggcatggta 634921 tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa aaagttttcc 634981 taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt gaaaaagatt 635041 cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga tagttaagtc 635101 gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc aaaaggttag 635161 gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt ttagtggtaa 635221 aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct ccattattga 635281 atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt tgaaaatcgc 635341 acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac acaggtgtca 635401 ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga tcctggctca 635461 ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg ggagcttgct 635521 ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt aagactggga 635581 taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg ttcaaacata 635641 aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta gttggtgagg 635701 taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg ccacactggg 635761 actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc gcaatggacg 635821 aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta aagctctgtt 635881 gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc taaccagaaa 635941 gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc gttgtccgga 636001 attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa gcccccggct 636061 caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag agtggaattc 636121 cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa ggcgactctc 636181 tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg 636241 gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc cttagtgctg 636301 cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa actcaaagga 636361 attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 636421 ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc ttcgggggca 636481 gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 636541 gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc taaggtgact 636601 gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc cttatgacct 636661 gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga ggttaagcca 636721 atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg tgaagctgga 636781 atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc ttgtacacac 636841 cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc ttttaggagc 636901 cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga 636961 aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga ccttgggtct 637021 tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc gaaacgtgtt 637081 ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga tatcacatag 637141 tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg cactaggagc 637201 cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag ctttgatccg 637261 gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata tctgaattca 637321 taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga ggaagagaaa 637381 gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac caagaggctt 637441 gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt agatgaagag 637501 gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg ttctctcctg 637561 agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga ggaccatctc 637621 ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg aaaggtgaaa 637681 agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag tagtcagagc 637741 ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg atcccgtgca 637801 aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc gcatgagtac 637861 gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt caggtaacac 637921 tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt gggtaggggt 637981 gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta gggctagcct 638041 caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac cgggttaccg 638101 aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg cgagtgataa 638161 gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa gtatacgtta 638221 agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa gcagccacca 638281 tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat gtaccggggc 638341 taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag cgttctaagg 638401 gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg ccggtatgag 638461 tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg aggaaggctc 638521 gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg atggacaaca 638581 ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc aggaggatag 638641 ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata ggcaaatccg 638701 tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt cctgattcca 638761 cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac cgacacaggt 638821 aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact cggcaaaatg 638881 accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga gagccgcagt 638941 gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg taaggcgaag 639001 tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag cgtaagcgaa 639061 ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta aggtagcgaa 639121 attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg cactgtctca 639181 acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc gacaggacgg 639241 aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc ttgtacagga 639301 taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt gggatactac 639361 cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca gtgtcaggtg 639421 ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc 639481 agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac tgcgagacct 639541 acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca tggaagggcc 639601 atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc aagagtccac 639661 atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc tgtagtcggt 639721 cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca gaacgtcgtg 639781 agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct gtccttagta 639841 cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag ggcatcgctg 639901 ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc ccccctcaag 639961 atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg ttgataggtc 640021 tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga ggacttaacc 640081 atatttttga atgatgtcac acctgttatc tagttttgag agaacactct caatttgttt 640141 ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt taagctcttc 640201 agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca agcattactt 640261 ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg aaggtcgcag 640321 gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc taagggtgca 640381 accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat gcctgcctgt 640441 cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa acgaaacgat 640501 catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg tcatagccaa 640561 gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa ctaggaagag 640621 cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa tttgatttga 640681 tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga ataggtgatg 640741 atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt gatactatgg 640801 tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg tacaaggcgt 640861 tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt tatctggtat 640921 cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat gaaggaatga 640981 atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt tctaccgctg 641041 acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag gcctgtttgc 641101 gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt tcttctgcag 641161 cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg gaaacggatt 641221 actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga ttatgctcga 641281 tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa ctgaacgaga 641341 ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca attcattctg 641401 atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt gaggattttg 641461 agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag tgcgcagcgc 641521 ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct aaagtgatcc 641581 taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat tttaaataag 641641 acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag aaacaaaagc 641701 aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat tagagggcga 641761 tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg gaattacacg 641821 tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg tacttcctct 641881 ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac ttgatgaata 641941 ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag aacagctgcc 642001 acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg aaattacctt 642061 tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac atgacaatat 642121 tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa gacactgtta 642181 tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg cctgctgttc 642241 attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt gtcgttgcaa 642301 aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa acacttgcct 642361 ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg gcaaatggcc 642421 ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag gtgtacacag 642481 gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa aatgtgatgc 642541 tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt ttaggccatg 642601 atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga ttcattggaa 642661 ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag gaaaaggaag 642721 cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct gaagcgaaat 642781 ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc agaaatatgc 642841 ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg tctccttgga 642901 cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat ctcgtgattg 642961 aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac gatgcccaga 643021 ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa acgctttttc 643081 gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt gaagtgaggg 643141 tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc ggcggaataa 643201 gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg acgataaatg 643261 agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga gactgctgca 643321 gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca aattgaaagc 643381 cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt tgaacaaatc 643441 actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga tattgatgcg 643501 attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt gaatgccgct 643561 aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat agccggtcat 643621 atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt ggtcgtttca 643681 ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt cattggggaa 643741 acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat gggattgcca 643801 tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa tattccgctt 643861 cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt gaagtctgcg 643921 gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc ggaagatttg 643981 tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc gcgcgcggca 644041 aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa cagaggcctc 644101 agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt cattcctcca 644161 ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat tgcttttgaa 644221 aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt gacttcttat 644281 caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa cagacaattc 644341 acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa gggctgaggt 644401 cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat aaagcgctta 644461 ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa agaggtgctt 644521 gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga gattccagct 644581 cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga tcctgataga 644641 cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg gtttgaacgg 644701 tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc cattcttttt 644761 cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta tcagtttcct 644821 cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta taataatcgt 644881 aatctcccag atactcctct atatggcttg aagaaagctc caatactctt gtggcgattc 644941 tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa tcaatcagcg 645001 cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca tcaaggatga 645061 gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt tcgcctccgc 645121 tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt ccgagacacg 645181 ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca aggacacgtt 645241 tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca tttgagccgt 645301 aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc aatgtcgatt 645361 tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc atgaatgaca 645421 cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga acacgaagga 645481 cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt tcatcgccaa 645541 gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc gcccttttgg 645601 tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca atctcgtcct 645661 gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg tcgagataag 645721 cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat acctggttta 645781 ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct gaatagcctt 645841 gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc ggctcatcaa 645901 gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt gttttctggc 645961 ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg agaccatgca 646021 gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat tcctgctgaa 646081 gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc gccatttttt 646141 cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca gtcagcagct 646201 cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat cccattgtaa 646261 tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg ataattttaa 646321 ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca cgatttctga 646381 cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac agctgattaa 646441 cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta gcttatgaac 646501 cagaagtcag caaacaatac attggccata taagacatag agaagaaaat agtgtatgat 646561 ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca gggcagagcc 646621 cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc tgtttcaagc 646681 gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg caaaggagat 646741 gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc gaatatcatt 646801 ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg gaaaataaaa 646861 gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag tacaggtgtg 646921 gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga tatgtgcaag 646981 gcccttgata agggaatggt catcggccct actttcttgc tggagaagac aggcgggaaa 647041 aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa atgaataagg 647101 atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat cgctttttaa 647161 agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt gatgccgtaa 647221 aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt ggcaaaaaag 647281 gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt gatcaggatg 647341 agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt cttcactata 647401 atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat gagagtaaaa 647461 taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa caacacgtaa 647521 aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc attacagaca 647581 gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt ttgaatgtgc 647641 cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca ctggtttatt 647701 ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg agcccaaata 647761 tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt atcttcggtc 647821 ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa tttaaaaacg 647881 ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag taagttagga 647941 tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag cttcgaaaac 648001 ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt tttttagcaa 648061 agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg cttaacgcgt 648121 ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc ggcatagtct 648181 tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc ctctatgaga 648241 aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt ttagcgggct 648301 tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag cggatttctc 648361 aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt cttctgcagc 648421 tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt ttgacaaggc 648481 tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat tttacgctgc 648541 tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg gtcacagtcc 648601 cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat cggaaagcac 648661 agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa atccatttct 648721 catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg aaaaggcgaa 648781 catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga tggagtaaaa 648841 tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc ctacggcaaa 648901 gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat aatcaattgc 648961 atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat gatgacgacg 649021 aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt tctcgcatat 649081 aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa atcagcgtga 649141 acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt tttttcgtac 649201 agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc gacgatggaa 649261 gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg tgtattttct 649321 gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc ttgagagaaa 649381 agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga gtccttctgt 649441 ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac aacgagacag 649501 gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc atctgtaggc 649561 tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc ggaaaactgc 649621 atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta tgtactcctt 649681 tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg gggtgaaaaa 649741 gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt tatcttatca 649801 cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct ttagtgctga 649861 gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa gccattaggt 649921 gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg aattgtgttg 649981 ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg ttcaggtcgc 650041 gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg cattatcttc 650101 tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat cttacgtgaa 650161 agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa acatttgagg 650221 aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc gcgcaatgct 650281 tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa aaggacgcaa 650341 cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg taacaatcgc 650401 taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg ttgctgaagt 650461 agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag ttcttgcgca 650521 agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg taggcgtgcg 650581 taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa tttctaagcc 650641 aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg atgaggaagt 650701 cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta tcacaatcga 650761 agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat tcgaccgcgg 650821 atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc ttgacaatcc 650881 ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc ctgtgcttga 650941 gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg aaggcgaagc 651001 acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg ctgttaaagc 651061 tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc ttactggcgg 651121 agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg ctcaattggg 651181 acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag gcgctggcga 651241 aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag aaacaacttc 651301 tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg gcgtagctgt 651361 catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc gcatcgaaga 651421 cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg gtggtacagc 651481 gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg ctcaaacagg 651541 tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac acaacgctgg 651601 ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg taggcttcaa 651661 cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc caacaaaagt 651721 tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa caacagaagc 651781 tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg atatgggcgg 651841 catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata catcaatgtt 651901 ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc tttcatcagt 651961 ttactaaact gttgggagac cttttctcca tattagcggt catatgagca taaatgtcca 652021 tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg cctactcctg 652081 cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca ttctttttat 652141 cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta attgcggatg 652201 accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat ttttaagctt 652261 aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc atcaattcga 652321 acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc aatttgattg 652381 ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc attttaaagc 652441 aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca aatggtccat 652501 ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt tttccaatgc 652561 tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata atcccttgag 652621 ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa caattgtgac 652681 tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt tttgctaatc 652741 gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc ccgtacactg 652801 cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa tgttttgaag 652861 ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac gtgacgggct 652921 gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag acgttttttg 652981 gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat tgcttgagtt 653041 ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta agtgagttta 653101 ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa agattggata 653161 aatttgagat ggaatcaatc ctgatggatt ctaaaagctt tgtaaatttc taattttatc 653221 ctggcctact gtgcaacaga ccttcttaat cgagcctaat tttccatcta tttgattggg 653281 gaacaaatgg ctttttaaca agaaagaagt ccaagaatac attgattggt ggtcaattga 653341 ggttaaaagg aaaaagaggg cctgatatat ctttcacttt cgcctaacta gcaaaattta 653401 ataaaacgat aagcgatgtg aggtgaaaat tatgctaagt gataataatt ttgtttccga 653461 aacactggag aatgtacagt atctattgcc aggtgcaaaa gtaatcaaat tgaggggata 653521 cagcagggcc cacaaagtat acaccattgc aaaatccccg gtagaaaagt ggaaggtcgc 653581 cgcaggttta tccggatcag agatagcaat tctgattaga aaaggtcatt ggattggtgc 653641 aagcattcca gctggcggaa ttgtcatcga tattgatgat tcaaaacagg gagagctagt 653701 gaaaggttta ctagatgcgc aaaactttca ttgtcattgt attaggaccc taatgggtgg 653761 cagtttattt ttaaggataa ccaacatggg gaaaagaaaa ttaaacaaat aaccaaattt 653821 tttactcaaa taggtatcat agtcgatgct gggatcgctg gggcaggcta tattgttttc 653881 ccaacaagta acactgagga cgatatatag taactaagag tcctaatgag ttagatgaaa 653941 tacctaatta tctgaggcct gtacggaatt ctgttaatgt aaaggacaac aacactggtg 654001 aaaaatatgt attccctgta ccaatcgaca gagttggtag cagaaatgat actttaaatt 654061 tgctacacat ttgaaagcct ggaaggtgga accatacgaa attagcaagg ccatggaatt 654121 gatttataaa taccttctgc tggataaaaa agatttctct ttggaggaat tttataaact 654181 caccatatat gctatcaaat ggaaactgga acaagctcag tttccattgt atttagaatc 654241 cacaaaaaaa tcgcatcaaa atgttattcc ccagccgttt aagataaaag gaaatgtctt 654301 atataaaacg gtaatcaaga atagcgggga ctttgaagaa tagctcatca tggcgtgtag 654361 gagtgattca cccttttaag aaactgtcta atatcgaaag aaacagtgtt cattatgaac 654421 tagcctcaaa cgataacgga cgcgaaaaaa aggatatagt tcctgctagt gttatatcac 654481 caagcgggag ttgcttttca ttggcggata atgggctagt tgagaaggaa gggcaaaaaa 654541 tgaagctgac agagagacaa cgacgctttt gtgatttctt tacagaaact agaaatacaa 654601 cagaggctac gcgtctagcc ggaaacaaag ggaaaaatct caacagagta gcttctcaaa 654661 acttgtcaaa actagacatt caaactatat agagcaaaga aataatcaac tagaagcgga 654721 gcgcatagca aacattattg aggtaaaaat gttttggaca attattatac gcgatggaat 654781 agttcggtta aagagcgact aaaggcgtct gagtatatta ctaaaacaaa tgcggccttc 654841 aaggaataga ttgaacatac tggtgaaatt aaaacaggga atgaggaaga agctaaattc 654901 gaatgagagt gatctaaggc ttctagaatt gtatatggag gtgtggtaac gtgagcaagc 654961 ttatatagaa ggattaagtg atcaagttta gtgtaatact aggaatgata aggtgttcat 655021 taacgcacat tacaactaaa aataccgtaa atgccctcaa gaggatgata tatccaaagc 655081 aaaaaccttc attctttcat gaatttaaag tattatataa gctactgaaa aagttttgta 655141 taaaaggtat aatgataaag aacattcgtt cttgtatggg gtactttctc tgagaatgaa 655201 aataatgtct tagggtgata taatgacaaa ttttatttta aatgaaaata aacagttatc 655261 attggcaatt gaagatgaga acatagaaaa tttttatata gatggtacag atttagtccg 655321 aaagataatc cgtagatcag gttcaggagt tacatcacgg gttccggtcc ttagcaccca 655381 agatttagaa aacaagaacc ttcatgaatt atacgatgaa tcttggctcc gtatgaaaaa 655441 cagacccaat actgagctca ctactgagag tataaatatt gcggatttat ttagtggatg 655501 tggaggtcta tccttagggg tttgggaggc atgccgtgcc ctggggataa atccaagatt 655561 ttcgtttgct tgtgatctta acgaagctgc cttatctgtg tacgaaaaaa acttttctcc 655621 cgattttagc ttgaatgaat ccatcgaaaa acatattaat ggcgagttag gtgctccatt 655681 aactgttgaa gagcaaagaa taaaagataa ggtgaaaaaa atagatttca ttctagcagg 655741 tcctccttgc caagggcatt ctgatcttaa taaccatact agacgaaaag accctagaaa 655801 cgctttacta atgagagtaa gtagagttat agagttgttc caaccttctt cagtattagt 655861 ggagaatgta ccaggaatta ttcatgataa atctggttct tttaaagaat ttaagaatca 655921 tttaaagaca caaggttatt acttcgatga aatcgtacta aatgctgaaa aactaggtgt 655981 ttcacaagca cgtcgtagat attttatttt tgcttcaaaa actcctgtat cttccttaaa 656041 tcaaataaat gaattttatt caaccaatag taggccaatt agttgggcaa tatcagattt 656101 agtagaaaat gtaggtgatg atatattcaa cactgcttcc gagcattcat tggaaaacaa 656161 aaggagaata gaatatcttt ttgaaaataa cttgtttgaa ttacctaatt cagaaagacc 656221 ggattgtcat cggctaaaac cacattcata caaatctgtg tatggcagaa tgtattggga 656281 tagacctgct cccactataa ccagagggtt tggatcaaca ggtcaaggga gatttgttca 656341 ttctttgtta aagagaacga taactcccca tgaagcagct aggattcagt tcttcccgga 656401 cttttttaac tttggtgacc ttcggaggag acagtatcaa gacgttatcg gtaatgctgt 656461 gccttccaaa ctatcctatt tattagcatt acatcaatta agataaaaag atttgaggtt 656521 gatatctttg aaagttgtta gtttattctc cggcataggc ggaatagagc ttggccttca 656581 tcagtcagga catacaacag aaatattttg tgaggttgat cctttggcaa aagctgtttt 656641 atcaaaaaac ttccctggcg ttaagataga agatgatatt aatgaaatta gagagttacc 656701 aagctgtgat ttagttgcgg cagggtttcc atgccaagat ttaagtcaag ctggaggtaa 656761 agaagggatt gacggatcac gctccggttt agttaagaaa ctatttgaac ttatagaaaa 656821 gaaagaacat gcaaatcgcc ctccatggat actaattgaa aatgtcccat atatgttaag 656881 gttaaaccgt ggtaaagcta tgtcatattt aacatctgtc ctttctgaat taggttatac 656941 ttgggcatat cgaactgttg atgctcgttg ttttggttta ccgcaacgaa gacatagagt 657001 tattttgtta gcctctttat ttgaagatcc aaaagatgtg attttttcac aggatcattc 657061 agaaccagat ttagatggaa agccttctgt tgtggatcat tccaactatt atggttttta 657121 ttggacggaa gggttaagag gtgtcggctg ggcacgtgaa gcagttccac ctataaaatg 657181 cggatcgtct gtaggtatag cctctccacc tgcagtttgg tctccttacg aggatatagt 657241 agggaccatt aatataaggg atgctgagcg cctacaagga ttcccggaag attggacaaa 657301 tatcactact gaaacaggta aggatataaa agaaggtgcc agatggagat tggtgggaaa 657361 tgctgtttcg gtaagggttt ctaaatggat tggtgaaaac ttaagtcagc caaaagggtc 657421 gatatcagat tttgaaggtg aattagtgac caagacttgg ccaagtgcag catgggggta 657481 cggagataaa aagtataaag ttcccgtatc aaaatgggtt gcaaacacag aacaaatagc 657541 tatttcagag tttttaaatc atccattaaa acctttatct gctagggcat taaacggttt 657601 tttaggtaga gcagccaggt gtacaaatgt aaattattcg gatgaattta ttaactcgtt 657661 agaacgttgt aaggataggc aacttcaaaa ggtttaactt ttcacattaa agagagcata 657721 ctaaaaagta tcggagctgg ataaaaccag ctccgttttt tatctttaat tttttttgca 657781 ttattccatc ttttattcga ccagttccat aaactccttt tcaattcttt gggggtttcg 657841 ggtctcggca agactttcat ctaccctgaa gtagaatttg atttttggtt ctgttcctga 657901 aagtcgcagg cacatccagg gatccgactt caagaaaaca tttaagaaca tttgactgtg 657961 gaaggcccat gagttcctca gggccttcca cagtctctcg attccggtca agtaatcctc 658021 aacagtggta accttgacgg aaccaaagct ggccaaattc agaacggaag gcagcgaggg 658081 tctgctgaat cagttctgcc ccttcttttc cctttagtgt taatgagcgc aggccttcct 658141 gaaagtagcc atattcttca atactaagga gagcttcgta tagtgaaatc cttttttctt 658201 atagtaagca catacctcaa ctgcaaggac atccgtctga acagcatcct tgtctcggac 658261 aaagtcgcca atcagatagc catagctctc ttcgtaccca aagaggaaat tatgttctcc 658321 tgtcttgtag tagccattaa tctttctggc aatgaactta aatcccgtta atacaccgat 658381 tgtttcgact ctgaaagagg ttgcaacttc cctcccaagc tccgaggtaa caatcgtttt 658441 aagaacgatc ccattagatg gaagtgttcc tttctttttt atttgggtta agatatagtg 658501 gagcagaagt ggctcggttt gatttccggt taaaaccgta tactcaccat tttcattttt 658561 aacagcaatt ccaagcctgt ctgcatcggg atctgttgca attaaatatc ggcgtcaatt 658621 tgctgccttc cctgatggcc agctcaaacg cggcatgttc ttcagcattt ggactggtga 658681 tagtggaaaa cagagggcag gctgctcctg ttcttttccc accgctacat gcttgtagtt 658741 cattgccgcc aaggccattg cagtagattt gctgtaccat gaagcggcgt aaatacaacc 658801 ttgatgtctg tttcatctta aatatttgag ttttctgaaa tagttcaagg tatgccttgt 658861 ccacctctgc gctatatttt gatcaggccc tttgctagga ggaagctggc cgccatctgg 658921 cccataaact ttatatccat tgtattcagg cgggttatgg ctcgcagtca caacaatacc 658981 ggcaaaacca tgaaggtgac gtactgcaaa cttaacacgg ttgtaggcct taatgactcg 659041 aaaacgtatg cgctggatgc cagtgtcctg gcggcttcca ttataaaagc cgccaaccca 659101 gcagaaactt tccttaacgt atagatgtca tccggtttgt tccagctcca atttccccgc 659161 gcatgcctcc tgttccatat cccaaattcc ttataaaaag catcttccag gtctttctca 659221 ttccttcctg atttacccaa ccccgatttt agctcggtgc aagttgacta aactgtagcc 659281 atttttctgt tttgtttttc cagcctatga ttgacctaca ataaaataac attattgttc 659341 attataatat agtctagagg ttttcgaacg acgactttct gacataaatc gagtgctctt 659401 gtctgattat gtctagttat agttggtttt ttttattttg tctctaaatt tgatgagatc 659461 atggtggcga ggaatttctt tttcgacagc cccaatcagt accaattcga tatttgaatt 659521 ggtctctcaa acaattccat cctctttatt tattatgata caattatatt aattagaaaa 659581 tacatacata ttagcttgtg tgattttatg ggggtaaaat caatgacttt tataaaaaga 659641 ttagaggacg cttatgaaac tctattaggg aattaccctg ccggagtatc tagtaccagt 659701 actagtaagt ataacgaaat acgaaagatt gtttcagaag ccttcttgat cggtgaaaat 659761 gaagtgtatg taacgggaac atcaagaagg attagcaatt tggacactcg gtttgctcaa 659821 ggaaatcaac ggaataaaca tacccggatg gcagttgctt ttatttctat accttctgtg 659881 gacgattcgg aattagatga actaattata agaacgagaa atagtgcaat tacaacctca 659941 tctaaattct gtaacgggga agaaaggggc acgatttttg acggaatatt acttttttta 660001 gtatttgagg gtgaaaccaa agtgtatccg ctagcattct tagttttcga gaacgatttt 660061 gaattaaagg aaaaggctga ggaattgatt ccaggaattg aactcaaaga atacccgcga 660121 gctaatcaat ccccagccca ggaaaataac aaaagcgcta aaaatgaaga tgaggaaagt 660181 gcaaagagct atgtagtctt ccttgatatt gaggaagatg gttctattgt ggaatttgta 660241 gaagataaag acaaaaccta tagaattggt gatatgattt ggacggcttc acatactaat 660301 ggttcatcag ctatcacacg cagactggaa gtaattgaag tcgttgaaaa tcttgtggtg 660361 tgtaagataa aacataaata taatgaacct gttgataaga attcactgct taagtttgta 660421 aatattgaac aagatttgat ttcatttcta gacttacatc caaatgtcca aaatggaagt 660481 gagggatttg tatctgggga cattgttgat gagaacgcta ctacatcatc ggatgactta 660541 ccggaagact ttgaaaataa ctaagcgata aactttaaat aggggaaatg aactgatgga 660601 aatatccaaa caaacttcag atttattatt gagcctagaa aagaaaaaag gcactttacc 660661 aaaattcagc gttttacgca gtattcctag gaataggatt atttatggtg caccaggaac 660721 agggaagagt aattatctag aaagggaagt gggaaagatc tttggtgata atccatatgt 660781 attcacccga gttacttttt tccctggtta tacatatgga caatttatag gtgcttataa 660841 accggttcct atatataaaa aattaagcgg tgaggaagag atatttagtt caaactttag 660901 ggataagatg gaaaactttg agccaatgat tgattatcaa tttgttcctg gcccatttat 660961 cgatgtatta attaaagctc tgaaaaatag atacactaat tttatattaa ttatcgaaga 661021 aattaatcgt gccaatgcag caagtgtttt tggtgatatt tttcaattat tagacagaaa 661081 taaaaacggt gaaagtgatt atcctgttac attcgggccg gacattatga attatttagc 661141 gagaaacgga attaaagatg aaatgattaa gctaccatcc aatttcttta tttgggcaac 661201 tatgaataat gcggatcagg gtgttttacc gctcgatacc gcttttaaga gaaggtggtc 661261 atttgaatat ttagagttgg aaaagtatag aaaggcagtg gactcttgga agctgagcct 661321 cagatataaa ggtcataata aagtaattat gtggaatgat ttccgagaca ttattaataa 661381 gcgtcttaaa ggaaaagtac cagaggataa gctgcttgga ccttttttcc tgaaagaaag 661441 tgaactgtgg aatcagaatg tatttaaaaa taaactgctt tattatttga aggaagatgt 661501 tttcaagcat aatccaacga ttgatttttt aaatgctagt actttctctg agctaattga 661561 aaaatatgat ggctcggata acatttttac ttttgacata gatgattcgt cttttgtgag 661621 tgattaacta tggataagtc aagtaagttc ttctttgaag atcaaaaata caataaagaa 661681 aggattgtac gtgtactcgg tggtaattta gctttactca aaagtaaagg tatattatat 661741 gaagattcta gtggggattt aatatttaac tatgtaggtg ttatatctaa tgggcgcaat 661801 gtaatattca ttttgcctaa atactgtaac aggcacttag atgaacattc aaagcggact 661861 ttgtttaata agttgctgaa gatttttaaa aaatattcag gtttaaataa aagccgggaa 661921 tctgattatt tcgtatcgga gctagatagt gatgaagtct ccgactttat gatagcagat 661981 tatttgctta atgatttctc attgaatggg tattatcaaa aaaaatttac tgaatatgaa 662041 attgatggag aaggaattat agattggagt aagacagtta atgaaattac cccagtattc 662101 tcaaagggag ttccatatta tttcagtact tataatgaag tggtacaaaa agacgagtat 662161 cacttgatag ttaaaattca taaatgggct ttaagtaaat attttaatga tttcggagtc 662221 attttaggtt ttacgggact agaatttgat aaatcctgtg atggtatgaa aattttggac 662281 tacgctgatt tttttggctc agtaataaat aaagaaatcg tgaacacata tgttgatcgt 662341 gacgttaaat tgttaaaggc attgaaaacc gcaattgata gggaagagaa tcagttttct 662401 aaacgaccca ctctttctct gtatggaaca aaatactttc acagagtatg ggaggaagta 662461 tgtaagaccg tattttccca tgttaatgaa tacgtaaaaa agatatcaag gccaaattgg 662521 attaacttta cggatataga ggttaataaa gagaaaaaaa cactagaacc cgatattatt 662581 aaggctttcg aataccgttc aaaagaatac tttttaatat tagatgctaa atattataat 662641 ataaattttg acggaaaaaa gctggagggg aatcctgggg ttgaagatat aactaagcag 662701 ctgttatatg ataaggcact tgaaaaactg tccagaggta aaacaaaaca taatgctttt 662761 ctgtttcctt cctctaattc aaccaatacc tttaaagtat ttggttctgt tgattttgat 662821 tttcttgata tagccgctgt aactcttgtt tatatttctg ctgaacaagt ttataactta 662881 tatcttgaaa ataaaacatt ttccactgat gacttattta aatttgtaag tgaaattaat 662941 aagtcaaaaa aacgacatag cgttataact tcaacattgt atggtaatat gtttttgttt 663001 acaaaaagat taagtgataa aaattagttc tagaaggtta aaagccgata acataatact 663061 tgtcctcggt tttgtcctcc tatagtttta aaaatattta tcagcattaa atgttaagtc 663121 taaaaaacag tattttgagc tggttttttt aatactattt tcaactgtta ttagtcggaa 663181 tgaatgggtt gcatgatgta aaaccgacaa aaaactcttg ataaacaggg gtttgtcggc 663241 aacggacttt tatttttgat gcccttttgg ccatttgcaa attttcaagg cttctcatga 663301 gttcaccgaa cttgtgagaa gcttcttttt tgatgtataa ataaacatgt gtagtgtgta 663361 caagcttaca tggcatttca tttatggacc gcttctctct ctattgcaga caggataccc 663421 tattggtata ctctcatacg acacaaaaaa gacccagtta tctaaataag tagtgccacc 663481 cactcttaga ctgtttcccc tagaaaagca ctgtcaaaga ggaatcctgt taaatcttgt 663541 gcttctttgc ttttttagct aaaagacgat gttttccttg caataaggaa ctcgtctttt 663601 atgttaaata taaagagcga cagaataatg acatctgatc cccaaaaatt cactgtcgat 663661 ggagttagat tcttccaaca gtaccttaat aaaatccgtc ccgacgctat ggagatagac 663721 aacctaatta tcaactctga tattatcaag gaggacttaa tagtgcatgt ctcaaaaatg 663781 atagatcgtt tggctttata tgatttacac agaaaaagaa gcatagataa acatttttct 663841 gctgctttta cagtcgatat caatgataga gaggaatttt acagtgcaaa tatagctgat 663901 gtttcaattg atttgaatga atctagtggt gtttaattga atctcatatt cttcagaaga 663961 accattcaat acttcttgaa caatatttaa agtattcatc agcttcctct actgaaacaa 664021 tatcttcaat gaaatcggaa aagtattcta gttctgttct tgttggaaga actattctta 664081 agtatcctaa agggtctctt ttaaatgaat ataccatgat aaatcagtct ttcctttctg 664141 tttattctta gttaatattg atcgtacaat tgagtcgaca agacaggcta ttgtagattt 664201 acgggcgttc attcactgga taaaagcaaa taaaaaaggg cctgttatca tagtcggagt 664261 aagccttggg ggatgggtta ctaatctaat tgctaccctg gaatcgaaaa ttgatgtagt 664321 ggtatctatc ttttatgcca atcgcctttc ttattcgata tggaacacga tcccaggtaa 664381 atacataaga gaagaattag aacaaaatgg tgtgacctat aatgagttaa taaaatattg 664441 ggatatcaca gatcctagtc aagccttgcc gaaagttaat aaagataacg tactgctgat 664501 ttctgctaaa catgatcaat atattgactt gaaagatgca gattatttat gggaaagttg 664561 ggggagacct acaagatatg tctacaattg tggtcattcc ggtattgttc tttgtcgcaa 664621 aaagctggca aatgatacgc tttcctttat acgagaaaaa ctggtttgat acatttgtag 664681 actttaataa gaaacgaaag gccaactgcg acttcagttg gcctttccta tttataataa 664741 agaaattgag tgagattgct gacagaacta cgtactactc gttttcttta gttgcccttg 664801 ctaatcgttc aacctctccc cgaatcccaa tcgcaggctc ccacgaatca atcaaacgaa 664861 tcgccttctg attagattcc accgctttcg ttttctctcc tttacgatac aacagctgcg 664921 ccattccgta gtgatagtag atcagttcaa cttgattggc gttatgtttg tcatagagca 664981 tttgctcaaa ggcttcttcc gctttttcaa actgatcaca tttcacgtaa gcgacaccca 665041 gattgaaata ggcttctatc gttttttcgc cgccgtatgt ggagctgatt tcatttgccg 665101 cttcgtataa ttgaatggct tctacatgat aacctctcgc aaagcttaag tcaccgcgaa 665161 ccaatagaac tctgtgttga atggtagggg aaatcggttg attttcgatt tcgtttaaaa 665221 ttgtctctgc tttttcctgt tgcccgtctt ttaaaaacag ccttgctttg agtgcatgtc 665281 cccaaacctt tagatcatag gcatcgtgag cgtctgattg ttcaagaatc ttcagcccgg 665341 cttctatttg ctgaagcgct ccgtctaaat cattgacttc catcaatgcc cagcctgagg 665401 tgtcgattcg gaagtacgct tctcgtgtgt gttggcctaa gtgatgggcg gcgtcggccg 665461 ctttgcgtcc gtattcgatt cgcaggggca ggttgattct gcttagaaaa tggctaatgc 665521 gggtgatgag ttcgattagg atttcttttt gttcagtttc acttgcccat tggatgacct 665581 ttaagatgtt tggccattct tgtttcattt gatctaagtt ccgtcccagc aggtagctcc 665641 aatagataga gttgggctgt tcccgcttta aatgggtttc ggcataatca atataatagt 665701 gcgcccagcg attgcgggct tctttttcat attcgtgctg ttcggacaag tgctgttctc 665761 cgtaagcgac aacggtttgg tgcgctaagt attgtgtcct gccttggctt cgttccggct 665821 gaatcagcgc atatgaccgc atttgttcca tagcgtaatg aaaacggcgg gcgtctaatc 665881 cggctgctgc cgccaggctt ttttcatcag gcggcttgct gaaaaagcaa agcgtctgcc 665941 agagctttcg cgtatcttca ttgcatctat cccaggtgcg gccaaagagg aattcaaaca 666001 attccagcag tgagtagcct gcttttccaa gctcatgaat cagctgctga gcggggatgt 666061 catcgtctga catataggca atgctgagtg ccatggcttt cgggtttccg gcagtcgctg 666121 aaatgaattc gtttttcagg tcagatgata gatgtaacag ctgctccagc ttttcccgtt 666181 tacgtgggag gttgcatgtt tgtaagcagt gatgcacttc ttgttgaaaa aattcgtggg 666241 catctgtttg gtcaagaccg cttagctgaa tggctgtcat ttctccgaag ctttcccgat 666301 aagtttgctt tacgttttcc cgcgctgtaa ggagaacttt tacgccttgc ggaaggctgg 666361 tgataaattc atgaatgtca cgttctgcag tatcaatgct gtcaacgatc agcaggatcg 666421 gtttttctct agtgtaattg gctaacgcat tgcggacgac aaaccgtttt acattgattg 666481 atttatcgat ttgttctttg cgtccgagct gataggcgat cgtatttaaa aaatcgctaa 666541 agcttaatcc tttccaatca gcgctgaccc agatgatgct gttgaatgcc ggccaaactg 666601 aagtatcgtc gacacaggaa taggcggctt caagagcaat tgtggttttt cccatgccgg 666661 cccagccggt gattaaacag actggtgatg gagaaagcat ccattgccgt atcgcttcca 666721 tatcaaagct gcgtccgata aagcgtccgg accagcgtga gggtaaatta tgcgtgatgg 666781 gctgttctgt aagcgcattc gtttcttggc cgggtctgtc atgaaacagc cgttttacta 666841 cattttcaat ttcgccttca ctcggagccc cgaataatcc gtcttttcgc agtattttcg 666901 cttttttcaa acaggatgct gcccatacag gcaatgcggg tttgatgact gggatagtgg 666961 tggcttccag caagtcggtc aaccactcga tatccaagtc ggtcttttcg agaatgatcc 667021 agatcattcc gaacagtttt ccgtcgtcga ttcttccggg aatgtagttt gcccccatct 667081 gtccgatcca gcttttgatc gtgtttgggg agactcccag ctggagtgcg attttatcta 667141 tgtaagactg tcctgttttt tcattctttt tccttctgac tttataatca ggatgaagtt 667201 ttagcgtttt gacgccaggt gccagcattt gtgcaaattg ttttcggttt tcaagttcag 667261 ccataagcct gcacctccta ttagtactat tttatcaatc cagcgttttt tgtatatgaa 667321 aaaataaaag tacagtgccg ctgtcctttt atacagcagg aaaggctgtt gaacgtgtta 667381 aaaagcagat aaaatggggg cagtaacaga gaaaacaaaa atgtatgcac ttacatttta 667441 ttttctaaag aaaggaactt gccaaatgac tcacacagta cctcaaaaca tgaaagcggc 667501 tgttatgcac aacacaagag agatcaaaat tgaaacattg cctgtgcctg atatcaatca 667561 tgatgaagtg ttgattaagg tgatggctgt cggaatttgc ggatctgatc tgcattacta 667621 tacaaatggc cgaataggca actatgttgt ggaaaaacca tttatccttg ggcatgaatg 667681 tgcgggtgaa attgccgctg tcggatcatc tgtcgatcaa ttcaaggtgg gagaccgcgt 667741 cgctgtagag ccgggtgtta cgtgcggacg ctgtgaggcg tgcaaagaag gacgctataa 667801 tctttgcccg gatgtacagt ttttggctac accgccggta gacggtgcgt ttgtccaata 667861 tattaaaatg cgtcaggact ttgttttttt aatcccagac tcactttctt atgaagaagc 667921 tgctttgatc gagccgtttt ctgtcggtat ccatgcggcg gccagaacga agctacagcc 667981 cggatcaacg attgcgatta tggggatggg ccctgttggg ttaatggctg ttgccgcagc 668041 taaagcattt ggggcaggca caatcattgt caccgactta gagccgctgc ggttagaagc 668101 tgcgaaaaaa atgggagcga ctcacattat taatatacgt gaacaggatg cacttgaaga 668161 gattaaaacg atcacgaatg atagaggcgt tgatgttgct tgggaaacag cagggaatcc 668221 agcggcattg caatccgcac tggcttctgt gcgccggggc ggaaaattgg cgattgtcgg 668281 tttgccttca cagaacgaga ttccgctcaa cgtgccgttt attgcggata atgagattga 668341 tatttacggg atcttccgtt atgccaatac gtatccaaag ggaatcgaat ttcttgcttc 668401 aggcattgtg gacacgaagc atctagtaac ggaccaatat tcgctggagc agacgcaaga 668461 tgcgatggag cgggcgcttc aatttaagaa tgaatgttta aaagtgatgg tgtatccaaa 668521 tcgctgagtg aacagggagg atcttcgtat tctccctctt gtttactgga aatgaaaacg 668581 gattcttggg gtgggaaatg atgattggaa cagaaaaagt aacggcattg aaggcgaagc 668641 atcagtcaaa atccagcacc ggcctgtcct ggtttgaacg aatcggttat ggattcggcg 668701 atatgtcgta taatattatc tttcagtttg taaacgcata cttattattt tattatacag 668761 acgtcggcgg cattcagcct gcggtaatcg caactttgtt tcttgttgtg cgtgtgctgg 668821 atgctatttt tgacccgatc atgggattga ttttagataa aacgaataca aggtggggaa 668881 aagcaaggcc atatttgctg tgggtggcat ttccttttgc gctattcaca ttcttatgtt 668941 tcacgacgcc tcatttcggt gagaccggaa atatggtata tgcgtatgtc acttatattc 669001 tgcttgggat gtcctttagt atgcaaacga tcccggtgaa cagcttaacg gggcggatga 669061 cgaattcggt ggaggaacga acggttctga ccacaacccg gatgattttg gtgtatatcg 669121 gcattctttt atccatttcc tgtgcgacac cgcttgcaac tgctatcgga ggagaggatc 669181 aggcgtttgg atttcagatg acggcgctca tctatgcggc tgtcagcatc gttttgaatc 669241 tatttagttt ctttactgta cgggagcgga ttcagcctaa aaagagaaaa aaacaaggga 669301 tcaaaaagac gttatccgtt ttattcaaaa acaaaccctt gctcatgtta atttcatcat 669361 ttttggcttt tgcgatcggg tttaatatta agctcagcac gatggtgtat tattttacgt 669421 ataacgtaaa ccataaagag ttcgtgttta tgggcaccgt tttatttttc ggggcagcgc 669481 tgatcagcaa tttgtttatt cctttctttt ctgagaagtg gggcagaaaa caagtcatga 669541 ttatcacggc agctctatcg cttatttctt atgccggcct gcattttacg ccgtattctt 669601 caattccact cattttcatt tggcttttcg cttcgggatt tttcacaacg cctttaaata 669661 cgcttgcttg gggaatggtt gcggattgcg tcgattatgc ggaatggaaa accggaattc 669721 gcgcggatgg tgttgtgatt tcgagcatga gctttattaa taagctgggt gttgcgttag 669781 ccgggtcatt ttcggccatt tatttaggaa tcgccgggta tgtggcgaat acagaccaga 669841 cagttgcgtc gttgaatgcg attaaaaata tgaatgcttt gattccggga tttttcattt 669901 tgctttctat tattcttatc gccttctatc ctttaacgga aaaaagatat aaacacatca 669961 tctctgagct ggagcaaagg tctgcgagat aaatagatgt aaaattttta atattcaatg 670021 ttgtatttat ggcaaaaagt aatatactga gactgtaatc tagactttat aaatgagtgt 670081 gataatatgc gtagtcattc tgtagtttgt attggggaat tgttgattga tttcttttgt 670141 accgatgttg acgttgattt aatggaaggg cgccaattcc tgaaaagtgc cggcggggca 670201 ccggcgaatg tgtcggcagc gattgccaag ctgggcggag acgccgcttt cagcggaaaa 670261 gtaggaaagg atccgtttgg gtattttctg aagcgaacat tggacgctgt acatgtcgat 670321 acctctatgc tggtgatgga tgagaaagcg cctacaacgc ttgcttttgt ttcattaaaa 670381 caaaatggag agcgtgactt tgtttttaat agaggcgcgg acgctttgtt tacgctggag 670441 gacattgacc aggaaaaact aaacgaagcg aaaatccttc atttcggctc tgcgacggca 670501 ctgttatcgg atccgttttg ctcagcctat ttacggttga tgtcgattgc gaaagacaat 670561 ggacagttta tttcgtttga ccctaactac cgtgaagatt tatggagggg aagagtctca 670621 gagtttgtaa gtgttgcgaa aaaagcgatc gctgtaagtg attttgtgaa agtcagtgac 670681 gaggaacttg agattatcag cggtgtgaag gatcatgaaa agggagttgc gatccttcat 670741 gagatcggag ccaacattgt cgctgtgaca cttgggaaaa gcggaacgct tctttccaat 670801 ggaaaagacc gtgaaatcat tccaagcatt ccggtgacat caattgactc aacaggggcg 670861 ggagatgctt ttgtcggtgc ggctttatat caattggcaa acacggatca gattcaatct 670921 gtagatgctg attttgtgaa actgcgtgag attgtggcgt ttgccaataa ggtcggagct 670981 cttgtgtgca ctaaaattgg agcgattgat gcactgccga gtttggatga gattggagtt 671041 tctttgtaaa tcattgaaga tgtttcttga aagtctttgg acttttgggg gcatcttttt 671101 ttattgctta catttttgtt caggtaaaaa gttgtatatt ttttgtttga aatgtcattt 671161 tttattaaaa aagtgaaact tttaacgata ataaatagta tatgtaacaa gggttaccga 671221 attagcttta ggaggaacga tataatgagt ataattggaa gatttaaaga tattatgtct 671281 gcgaatatca atgctttatt ggacaaggct gaaaatccgg agaaaatggt agatcaatat 671341 ttaagaaata tgaatagcga tttggctaag gttaaggcag aaacagcagc tgttatggct 671401 gaggagcaga gagcaaaaag agaatatcac gaatgccagg cggatatgga aaagatggaa 671461 agctatgcaa tgaaggcgct gcaagccggg aatgagagcg atgcgagaaa atttcttgaa 671521 agaaaaacat ctttggagtc aaagctttct gagctgcagg cggcgaatca aattgctgca 671581 accaatgccg cacagatgag aaagatgcat gacaaattgg tatctgacat tggagagctg 671641 gaagcacgca aaaatatgat caaggcgaag tgggcagtag cgaaaacgca agaaagaatg 671701 aacaaactgg gcgcttctgt ttcaagtaca agccaatcaa tgtctgcatt cggccgaatg 671761 gaggacaaag taaataaggc acttgatcag gccaatgcaa tggctgaact gaacagcgct 671821 ccgcaggatg atatggctga tctgtctgca aagtatgaca ctggcggttc aagccaggtt 671881 gatgatgaac ttgcggcgtt aaaagcgaaa atgatgctcg ataagtaata cataggaggc 671941 cgcagctttc ggctgcggcg tcattttatc ataaaatgtg agagggaacg gtaatgataa 672001 tatcttataa gtgtccgaac tgcggcagtg atatggcatt tgacagtgaa accggctcgt 672061 tatcctgcag cagctgcgga agacaggaca atattgaaag ccttccgaaa gaaaacattg 672121 cggcacggtt ttctgatgat gaagcaaaag aatatcaatg taaaaactgc ggtgccgttt 672181 tgatcacgga agctgaaacg acagcaacga cgtgcagctt ctgcggaggt gctgcaatac 672241 ttgccgatcg tttatcagga catttggcgc cggcgaaggt cattccattt acaatcagca 672301 agcaagaagc ggagcaggca tttcgaaagt ggtgcaaaaa aggccttctg acaccaagag 672361 gtttcatgtc tgctgatcgt atcaaaagca tcaccggcat gtatattcca ttttggatgt 672421 ttgatttaaa tagtgaagta caggtgagag caaactgtac cagagtccat caatatgaag 672481 aaggggatta tatttgcacg gaaacagagc actttgaagc gtttcgtgat atcaatctcg 672541 attatttgaa aatccctgtc gatgcctctg aaaaaatgaa agacgaatta atggacaaat 672601 tggagcctta ttcatacgaa gagctgaagg actttcaaac ggcatatttg gccggttata 672661 ttgcggaaaa gtacaattat accgatgagg agctttttcc gagggcaaaa gagaaaatca 672721 gcagttatat agattcatac atccattcta ctttttccgg atatacgtca gtcaatgtga 672781 gggacaaaca tattcacacg aaaaacgtga acagctttta cgttttgctt cctgtttgga 672841 tggtcagtta cgattatgaa agagcggagc atatctttgc gatgaacggg caaacaggaa 672901 aggtcgttgg aaagccgccg atcagtcgag gaaaagtggc tgcatggttt agcggaatag 672961 caggcgggac atttcttgcg ttgaagctcg tctcattgat gatgggaggc ggattttgat 673021 gcgtggattt tttgggaaag cgatctttgt tgtgctggct gttttcatca tgatgccttt 673081 actgggtatc gaagcggtaa gagcctctga attgcagcag catgtgtacg atcgcgctca 673141 tctattgtca aaagcggaga tcggaaaact tgaatctctc tcggcaaagc tgggtgcaaa 673201 gagggacact gatttcatca ttattacgac caaaagcaca aacggtgaag atattgcaga 673261 ctataccggc gatttttatg atcgttacgg aaaaggcagt acagccattc tgacgattga 673321 tatgacaaac agagaagtgt ttatcgcagg ctttaaaaaa gccgaacagt atttggacaa 673381 cagcaggctc aatagcatca gaaatacgat ttcatctgat ttatccaatg aaaattattt 673441 tgaagctttt gagacatata ttcagctttc ctataaagat atgggcataa aaccgggagt 673501 aaaccctgac aacatattct ttacatggtg gtttcagctg attgctgcca tcgcagtcgg 673561 gggaattgcg gtttcaatca tgctttatca tgcaggcggc aaagtaacgg ttaatggaag 673621 tacatatatg gatcagcgta cgtctgatgt gattgatcaa tacgacactt atattagaac 673681 gactgtaaca agagaaagaa aaccatcaga taaagacagc ggcagcgatg gcggtgttac 673741 gaaaggcggc acgtcataca gtgggagccg gggcagtttt taaatgtaag aaatagagaa 673801 agggagaggc gtaatgtcgt ttttcagaaa tcaattagcg aatgtagtag agtgggaaga 673861 atttagagat gatatgattt tttataaatg gaacaatcgt gaaatcaaaa aagggagccg 673921 tttaatcatt cgtcccggac aggatgctgt ctttttgaac aatgggcggg ttgaaggagt 673981 ctttcaagat gatggcgatt atgatattga atcagaaatt attccattcc tttcaacgtt 674041 aaagggcttt aagtttggct ttaacagcgg catgcgagct gaggtgctgt ttgtcaatac 674101 gaaggaattt accgtaagat ggggaacaaa acaggcgata aatattccgg cagcgggaat 674161 gccaggcggg atgcccattc gcgcaaacgg cacatttaat ttcaaggtgc aggactatat 674221 cagcctgatt gataaaatcg ctggcgtgaa agatcaatat tttgtagagg atattaaaac 674281 ccgtatcatt tctattctgg atcagcttct catgaagtgg atcacaagag aagggaaaga 674341 tatgtttaat cttcaagcaa acgcttttga tattgccaag ggaattcaag aggacttaga 674401 tatgcaatta ataagcgacg ggatgacggt cactggtttt caaatcatga gctttaatta 674461 tcctcaagag gttcaagata tgattacaaa gaacgcttcc tacggtatgg ttggggatgt 674521 gaacagatac cagcaaatat caatgacgga tggaatggca tccggaaaga tgagcggaag 674581 cggagcggct tcggatatgg ctggaatgat gatgggaatg aatatggcca atcagatgat 674641 gaaccaaatg aatcagaatc agcaggcaca gtcatcaggc ccacagtcaa ctggcagcgg 674701 aagcaaaccg aatttctgtc caaactgcgg aacaaaaacg ggcgaagcca atttttgtcc 674761 gaattgcggc cagaagcttg tataagaatc atacagtgaa aagtccggag tgatcagcac 674821 tcgggacttt tttatttagg agaataagca ttacctattg cttgctcctg aacaggccat 674881 tttcgagccc ccgcttggat aattcccagc agcaattgac gacgttcctt tattgaattg 674941 acggcaattt gaaatgtttg ctttgataaa gccggtatgc ctgattgttg aagctttgag 675001 atgtctggtt ctggcggcgc ttgttctgca ggatggatat aggcagtatg aacggtatcc 675061 agatagtttt tgatacttga gcgcgcttct ttgatatgaa gctgattcgg ctgatattgt 675121 tcaggaattc cgtatttgaa aatggttaga gcctcatcca atacagcaac agctataatg 675181 gatgattcct gatgctgcgt gctgtggtaa aaatgaagga tggggaaggc gttatgctga 675241 gcggtcagct ttcccagttc tgatgaggca gcgacaagaa gaaaatcaat gtcgtgaaaa 675301 tctttgccat tccatgcatt atggacgatt tcagttccgt catgccctag acttaataca 675361 ctttgggcaa aggagcgttt ttgattaacc gcactcaaga cggaaatcaa atacgtgaca 675421 gaaaatgtga tggtaagcag tccttgagct gtttcaataa tcgtgacaag cttccatagg 675481 cctccgttcg gagcgaggtc gccatttcct aatgtaaaca tgacatagcc ggaaaaataa 675541 attcggtctg accaggaagc cggttctttt gattgagttt ccataagtga gtgagggtca 675601 ctcgagtaaa tcaaaaccca cccgctccaa aatagactga tccatatcac taacgtcagg 675661 cataacagca gaggaccagc catacttaga acctttgcgt ggtcaccgct gattttgcgg 675721 cagcccttcc acagccaggc agacaggcat cttgtgatcg ggccggcacc gctctctaac 675781 cataacgtgg tccataaaaa atcaatcatc cccgctgtca ataataaaag gcctgcaatg 675841 atataaccct cattcatttt ggttgcctcc cttaagtcag ccttctttta ttttcttctc 675901 tatttccttt tatcctgagt ctgaaacaat tgaacgaatg tttgatttta cagagaaaaa 675961 taggtgggag ttacccaaca cttactcatt tttcaatatg aacagaaaat cacaagattt 676021 ttgacttgat tcacacattt tcatgaagaa aaacgttcat tttccccttg aattggtgat 676081 tttcctttta tagagtaaaa aattttcaga aatttatatt gactgaaagc gtttttataa 676141 ttatgataat atcagatata acaaaaatgt cactataaca tcactacaat tgaactatta 676201 agtgactaat aaataccaaa tgaacgaggt tatgcacaaa gaaatgacca ttgttctttt 676261 aacgagaaat gaaatcgctt ccatagggat tgacatgcta agaagaaggg aaggttatga 676321 ggttattgga taaaaacatg aacaactatt ttctgaagcc tgcttacgaa atgtgaggaa 676381 ggcagcagcc ctggaataag tttttgacat acgcattttg aaaaagactg ggggaaacag 676441 tatgaataaa caaggaaatc aaatgtcatt tttacgtaca attattttag tctccacttt 676501 cggcgggctt ctttttggct atgataccgg tgtgctcaat ggagctttgc cgtatatggg 676561 agagccggat cagcttaatc tcaatgcctt cacagaaggc cttgtcacca gttcacttct 676621 ttttggagcg gcactgggtg ctgtgtttgg cggcaggatg tctgatttta acggccgccg 676681 caaaaatatt ttgttcctcg ctgttatatt ttttatttca acgattgggt gtacgtttgc 676741 accaaatgtt acggtcatga ttatttcccg ttttgtgctc ggtattgcgg ttgggggtgc 676801 atccgtaacg gtgcctgcct atttagcaga gatgtctcct gtggaaagca ggggacggat 676861 ggtgacgcag aacgaattga tgattgtatc aggacagctt ttggcctttg tttttaatgc 676921 gatccttgga acaacaatgg gagacaactc ccatgtgtgg aggtttatgc tggtcattgc 676981 gtcacttcca gccttgttcc tgtttttcgg catgatcaga atgcccgaga gtccccgttg 677041 gcttgtttct aaaggaagaa aagaagatgc tttgcgtgta ttgaaaaaaa tcagggacga 677101 aaaacgggca gcagctgagc tgcaagaaat tgaattcgct ttcaaaaaag aagaccagct 677161 tgaaaaagcg acatttaaag atctttcagt cccatgggtg cgccgtattg tgtttattgg 677221 attagggatt gcgattgtac agcaaattac aggtgtgaat tcgattatgt attatgggac 677281 tgaaattcta agaaattccg gtttccaaac ggaagccgct ttaatcggaa atattgcgaa 677341 tggcgtgatt tcggtattgg caacattcgt cggaatctgg ctgctgggaa gagtggggcg 677401 ccggccgatg ctgatgacag gcttgatcgg tacgacaaca gcattattgc taatcgggat 677461 attctcactt gtacttgaag gatcaccggc acttccgtat gtagtcctgt cattaacggt 677521 cacatttctt gcttttcagc agggcgccat ttcaccagtg acttggctga tgctatctga 677581 aattttcccg cttcgccttc gcggactggg aatgggtgtt acggtattct gtctgtggat 677641 ggtgaatttt gcagtcagtt tcacgtttcc gatattgctg gcagctatcg ggctgtccac 677701 aacgttcttt atcttcgttg gattaggaat ttgctctgtc ttgtttgtga agaggttttt 677761 gccggaaacg aaagggcttt cgcttgagca gctggaggaa aacttccgcg cttatgatca 677821 cagcggggca aagaaggatt ctggggctga agtgattgga taatttaaaa aagaatccgc 677881 acccgagtgc ggattctttt tggtttcaaa ttagttaggt ctaacaagga ttttgacttg 677941 gcttttctct ttaataagag ccccgaagcc ttcctcgatc aaatcatcta gtacgatttt 678001 tttcgttacg agtttgtcgg ctgagaaata gccttctttc attaatgaca atacagccgg 678061 gaagatgtcg cggtatccga taattccttt tactgtacgt tctttgatta cgatatcgtt 678121 cggatggatt tcagcacctt tttcccaaat gctgacgatg acggtttcac cggcaattgt 678181 agtggactgg atggcttgtc gtaacaccac tgggacacca gtgacttcga atgctacgtc 678241 aacaccgcct cctgtacgtt ctgcaatctc agcgactaca tcgtctgttt tagacggatc 678301 aacgatgatc gcgccaagct cctcagcttt ttgctggcgt tcaggagaaa gctcaacagc 678361 gtaaatatca gttgcaccgg cagccttcag cgcttcaatg acaagaagtc cgatcgggcc 678421 gcagccgaat acagccgctt tgtcgcctgc tttgagtttg cttgagcgga cagcgtatag 678481 agcaactgca gaaggttcaa cgagcgcgcc ttgttcatat gataattcat caggaagttt 678541 gaacaaaagc tcttcatcca cagagacgta ttcagagaaa ccgccgcctc cgccggctaa 678601 gccgaggaat cccatttgtt catcaaggtt gtaggcgcct tggtggccgt gtgtagcaaa 678661 aatcggctcg actacaacgc ggtctccaac tttataattt tcaacgcctt ctccgacttc 678721 gacaacttca ccggagaatt catgccccat tgtgacaggt gccgtttcat ttgttaatgg 678781 gtgcggtttg tcaaccggaa taaagatcgg gccgcccaga tattcgtgta aatcacttcc 678841 gcagatgccg caccatttga ctttgatctt tacttttccc ggctccgttt ttggctcttc 678901 gatatgttca atacggatat ccttttggtt atgccatctt gctgccttca tggattacca 678961 ctcctataac ttttgatgtg agtaattccg caccggtcaa tatgaactgt tcacaaaatc 679021 gccattttta aaaccaaaaa agaaatgaaa tttttatata atataatcta cgtttttttg 679081 aaaaaaagaa actttaaaga aaaaagggtc tcgcacactc ttttttcttt atatgagagt 679141 atcaatcgtt tacatagcta tgaatttggt ttgaacaata cggtaatggt tcgttcatat 679201 tgaatgcgac aactactcta tcaataatta taactctaat actgctatta taataggata 679261 atcttccatg gtttatttta gcagaggtaa cttttttgac tttgtaacat tactgtaagg 679321 atattgaaat aaaaaatagc tggttgatcg tgtataatct tcctagatgt taacaaacag 679381 ggggacgaaa tgttgaagaa agtcatttta gccgctttta tcttagtagg aagtactttg 679441 ggagctttta gtttttcatc agatgccagt gcgaaacatg tgaacggaaa tattacttgg 679501 tataatggag tcgggaaaaa aggctcttca ggtaagaaac ttggacattg ggattgtgcg 679561 accaaaatcg gatttgatgt tcctagaaac gggacaaaaa tcagagctta tgcaaaagcg 679621 aagcctaaaa aggtgattac ggtttataaa aatgatgttg gcagaatgcc taatgcagtg 679681 ctggatgtta gccctaaagc gtttaaagcg cttggatacc cattaagcaa aggtaaagta 679741 gcggggcatt acagctatta atgtacatat ataatctgga aagcaagaag tcacattctt 679801 gctttttcta ttggtggaga taaaagatga aaaaaagaat catattatta ttagcagtga 679861 taatagcggc agctgccgcg ggggttgcgt tttatgttgc aaaggataaa ggccatgaga 679921 aggctgctga tgtttcagtc aataccgaaa gcggtgatga gctgctggtt tcaattacag 679981 atacggatct gctgacaaag tattatgaaa atgacaaggt gatccatgag gagaagctga 680041 ccagctatcc ggcatttgcc ttggatcaaa aacagcaggt gctctattat acgggcaata 680101 atgaacagaa tgaaatgagg ctttttaaat tggatctgaa gtctcataaa aaaacgatgc 680161 tttataaagg cgcggagagt gcggacagtt tatttttatc aaaggaccgt tcaaccatct 680221 atttccgctt aggaaaagcg gacgaaagca attttcgaat cgccgctttt gatctgaaga 680281 cgaaaaagta taaaaatctt tatcctgccg ctaatgatca ggatgacacc gtcagcagct 680341 tcttttataa ccaaaaaaac gattcatttg cattgcttca ttattctgta gaagaagact 680401 acaagaaaac agatgaagca aacgaaaagg gcatcgaccc tgaaccgaca acgattcatt 680461 ttgcggaagg ccgccaaaat aaatttaatg agctgaaaag cctgaaccaa tttatcagcg 680521 atattgctgt ttctgatgat gataaacgta ttttattcac atcatatacg caaaaaggaa 680581 cggagcaaac cgcttctatt caaatgctca atgcggatac gaaaaaatat gaaagcatca 680641 tctcaaatca aaaatcattt aagctgttaa ttgacgcaca gcctcagttt tctaaggatg 680701 ggaagaacat ttattttctt gccgaagcca agggggctaa aaagctgaag gacgaaacag 680761 ggcgtgaagc taaggtgcgg acgatttatt cctatagcct tgagaataag accttcaaaa 680821 aagtatggga aaatccgaac ggcatcatca acagcttttt tgtgattaac taataaaaac 680881 cactcggcat gagctgagtg gcttttttaa tggatgaggt gcagggctaa tgatccgagc 680941 catttaaaga tatgaatcag aggtaccgac aaaaacagaa gttcaacata tgagttcatt 681001 gcaacattca gctttttgaa cgcagctctt tttttcaagt ctttttgctg ctggtttgag 681061 atcacgttat cactcctctt atatccatat tataccatta aaacagacaa aaaagcccta 681121 aacgtttaca gttttgggct tctttcttcg tatttggcct cttgcaatga gaggctttta 681181 ttctgaaata tagaattttg tctccgttcg gggtttgttt gcttgcggga gactgcattt 681241 gttataggga agaactagct tgttttcgtt tggctgttgt tttggagatt cactaatgaa 681301 cggatgccgt cgaccatttt acttccgcac aaagggcaca atggcgtatc actgctggcg 681361 aagttttttc gggtccagcc attacagtct tcttttgtgc attcccaagt actcacatct 681421 tcctttggca gcggttcttg atttcgtttg ttatagtaag acataaagtc acttcttccc 681481 tcatgtattt tactgcacat ttcctattgt ctcatacttt tccctaatct cctaattcct 681541 ttttctttat gactttccaa taaccccatc taaaaaggag aggagtgtgc tgttaaaagc 681601 atctggctct tctaaaaacg ggcaatggct gcttttagga aaggtaacga gtgtcgcgtt 681661 tggaatattg ctgcgcaagt gttccccagc tgctgtagag aaaaatttct tgtcttcccc 681721 gaagcacagc aatgccggca cattgatgtt ttggagggtg ccccggtaat cagcggccgt 681781 ttggttaaat aaaatcgtgc tagaaatggc agccggctgt ttgaggattt ctgccagcat 681841 ccattctgtt tcggtctcgg caggcggttc tgcgaacata ttctggatga agctttcgta 681901 gaaaggcagc gggtcagttt gaatggcgtg catcgctgtt tttaagccgt caaaatcaaa 681961 tggaccatgt tcccagccct cccattgata gtccgaagcg gattgatcga tgatcacagc 682021 ggcttgaatg ttatcattcc caaactgatt gagataatcc catacgacaa aagcacccat 682081 tgaccagccg gcaagaacga catgatcaag ctccattgca tttagaaatt cccttatgtc 682141 acgggcatat tgggaaatgg tgtggccgtg aagcactttg tcagattcgc cgtgtcctct 682201 aagatcaaga cgaatacatt gataattggc agaaagcacc gaaaattgtt tgtggaaaaa 682261 ttgtccgctc atcagcaccc catgtataaa caggatcggc gtcccgctcc cgtgtgtttc 682321 atagtaaagg cgtgtctgat cttctaatat gatgtatggc atgtttctcc tcctttagtt 682381 tccatcatga gtatggctgg ctgctgttga gctgatgatg gcagctgtcg cggctgcctg 682441 ctgcgcttga atgactgttt cgatagcggt gtatagtcct gattccatca gcagattttt 682501 ctccatatgc tcactgagat agaggctgac agcaatttta aagttcattt ccttttgcca 682561 tttaaaagct ttttcctggt ttaattcgtc agtgatgcac aaaacggttt tgatatctgg 682621 ctcttccaga aatgtgagga gagcaaggtc tggataatga taatcctttg tttttttgac 682681 agattcagtg atcgattgat atatctgttt gcaagcggaa acaagcattt cgggctcttt 682741 ttcactttgc aaggccagaa tatggctgac ctgatgtaag tactgtcctt ttttaaagcc 682801 gttggctgcc agcagttgat agcatgtttc cgccttctgt agcgcctgca aaccttttcc 682861 gttttctcca agcagtacgg caagcggaac attctgagtt gaagtgagga aataatgatt 682921 tttcttcatc tgctgataaa cagctagccc catgttcatc tgttcttttt ggtttgtcgt 682981 ttcagatttg ccggtgagca agatcagagc ggaaaggtat gtgaacatat cccgcttata 683041 ccctagcttc accatttcat tgtatacatc gatgaaagtc tgaaatgttt gttttgcctc 683101 atgctgaaaa tgaatgtcca gaatagatgc aacagtaaag cggtggtgtg aattgagtgt 683161 tgagaagctg ccgatgtttg atttgatata gctgctcaaa tcataaaagc gctgaaaatc 683221 aaactctctt ttattcacaa tatatgcaga agaaatgagc attaatatct gatcgtgtga 683281 aactttccat tttaattttg tttttaattc agcataaatg gaaatgtaat gctttgtttt 683341 ttcatgtaga tcgtgtgtga gcataaaaag cagctccttt tgttgttttt acgtaatacg 683401 ataaataggg ccaaaggttt cataaagaaa aaacttgcct gctagaggca agtttgtcgg 683461 gttatttatg gggatcagtt atatccatcg gtctcatcat gtcatagtct tcatgctcta 683521 gaatatggca atgccatacg tatcgtccgc tgtacggacc gaatgtcgcc gcgattctca 683581 ggacttcacc tgcatgcgct tgaatggtgt ctttccagcc cttttcactt ggcggcggcg 683641 ggacagccgg accggtatag gacaattccc cgctttcttg ataacgggcg atatcaaacg 683701 gccgccggtc taatacacgg aaggagacta gatgcaggtg gatcggatgt gttccgcgtg 683761 tcgggttgat aatggaccat atttcagttg tgccgacttt tggtgtttct gtgacgggat 683821 cgtgccagcg tttgttatta agcagaagga cgggtctgcc gtattcgtcc tgggtgcctg 683881 ccagttttaa cgttctgatg ttttgtattc tttcatgctg taccgaaggg tatgaggcga 683941 ggtacttcgg ctttctgctt tcgtcttttt gtgccaatgg ttttgtgact ctgaattgca 684001 tgatattcgc atctgtttca ggattgacgt caccgccgca gcccgcgctg tttgccaaaa 684061 tgatcgattc tccttcatat gctgtgaagt caatgatgat atcgtaacgt tcagcaggcg 684121 caaggctgaa agaattcagt ttaacagatc gcggcaggag ccctccatct gaaccaatct 684181 gaataaaatc tccgccatta tcgagtgaca ggttataggt tcttgtattg gaggcgttga 684241 tgacacggaa tcggtatttc cttggctcga cttccaagta tggccatacc ttcccgttga 684301 cgagtatggt ttctccgcaa aaagccggaa cgattgaagg attaggcagt gacggagaag 684361 ggttttccgg tgcgctcgga taaaacaaag aaccatcctc attgatcgtg cggtctgtga 684421 taagaagcgg cacatcgtat tcgtctgaag gcagttttaa gcgtttttcc tttgggtcat 684481 gaatgatata tgcaccgaca agtccggcat agacatttag cctggtgagc gccatggcgt 684541 gatcgtgata ccacaatata gccccgcgct gctggtttgg ataatgataa acctctcttt 684601 tgaaataagg tcctgtttgt tcaaagtctt tggaaaacca agcctccgga tacccgtcac 684661 tatcatctgg cgtgacgccg ccgtgtaaat gaacaacagt ctttacctcg ggctcttcat 684721 gctggctgtc actgtgatga atggtgtgat caatcggaag gaaatgcgtg gaaggaaggt 684781 tattcatcca ttttacatat acgttttcat ttcttttaac ctcaatggtc ggtcccggaa 684841 ataagccgtt gtagccccac aggcgggttg gagggagatc gcgatggagc tgatgagtgc 684901 attcctccat ggtgacttcg tagtatgttt tttcttttga ttgctgtact ggctttagtg 684961 tatctgggat tgggagagca tccacaaatt tttcaagtgt cattttcatc tgtccttatc 685021 taaattttcc aaattggtac tatagttaat gacaataagg acgtgatggt tacaaaaaat 685081 cttcgtgctg cagcccgccc gaagaagaaa ataacaaaat cctaaacggc aggccgttta 685141 ggatttgatc agcattaagg caggatatcg ggttgctgct gtgtgactgg gttggcagcc 685201 gctttctcgc tcaccttgcg ttttctgaac acaaggtaag aaatcagaac gattcccgtg 685261 atgacgcctg tcagcagcag ctcgtctctc atggaatcaa taaacgccat ggacactaaa 685321 attccgcaaa tggcgatgat ggtcaagtag gttaggaaag ggaagagcca cattttgatc 685381 ttcaatgctt ctgggtttgt tttttcgagt tttttccgca ttttcagctg ggaaacggcg 685441 atgacaagat agacgagtaa agcgattgcg cctgatgagt tgactaagaa taaaaagacg 685501 gtatccggtg aaaaatagtt cattacgacc gcgatataag agaaaaatgt cccggccaca 685561 atggcttgta cgggaacgcc ttttttgctc aatttcataa aacggcgcgg cgcttcattt 685621 ctttctgcaa gtgaatacag cattctggat gtggtataca aacctgaatt caggcaagag 685681 agtacggctg tgaggacgat aaagttcata atctgtgcgg ctgcgggcac tcctatatgc 685741 tcaagtacag cgacgaaagg gctttctaaa atatttgctg aattccatgg caacagcgcc 685801 acgacaatgg cgattgagcc cacgtaaaag acgatgatgc gccatacaac ggatctggtg 685861 gcttttgtca cagattcgat cgggttggat gtttcccctg ctgcaatggc aacgatttca 685921 gttcccataa aagagaagat gacaacgaca atgccgagca atacggagct gatgccctcc 685981 gggaaaaatc cgcctttgcc tgtaagattc gaaaaaccga ctggctcact gcccggtgca 686041 aagccaaaaa taaaggcaaa accaacgatt agaaaagcaa tgatagtcac aactttaatg 686101 agggagaacc aatattcaaa ctcaccgaaa gacttaacgg agtagacgtt tgtcagggtg 686161 agcacaatgg tcaagatcaa acttgtcagc cacagcggaa tatcatggaa ccagtattga 686221 ataatgccag caccggcaat ggcttcgatc gctatgacga tcacccagaa aaaccagtac 686281 agccagccga ttgtaaatcc tgcccacggt ccgatggcgt cgtgagcgta ttgagaaaac 686341 gatccgctcg tcgggtttac ggcagacatc tcaccgagca ttctcataat aaaaatcacc 686401 aataatccgg ctaacgcgta agaaacaacg gcacccggac cggtcgagtg aatcactgaa 686461 ccgctgccta caaataggcc ggctccgatt acaccggcaa tcgaaatcat tgtcatatgg 686521 cgggtcttta attccttttt taatcctgat tgagactggt tcataagtta cctcctttta 686581 aaatgcaatc attactgaat attatgataa ttgaaactct atcataaata tacagtttgt 686641 cgaaaattcg tgtaagaaaa tataccagct tatttcaaat ttgtagtgtt ttgtttgcgc 686701 tttcagcgaa tgtgtggaaa aaatgtttcg ttttttattc gctgtgtgat tttgcgtaat 686761 atttacaatt cgatagaatg cgagaagcac tggtgtcctt gggtttgatg ggatttttgg 686821 cggagcaaat aaattggatg agagaaaaag tgttccttcg tcactatttt tctgtggcgg 686881 gtgaatcatg tttctgtaga cccactgcgg atcagctttg taagataata ataggaaaat 686941 gtgagcgaga ggaggttttg tatggagaga tatgatgaac tgaaaaaggg agaatccgga 687001 gcgctggtca gcattgccgc gtatctagtt ctttccgcaa ttaaactgat catcggttat 687061 ctttttcact cggaagcact tacggcagac gggttaaata acacaactga cattattgct 687121 tctgttgctg tgctgattgg cctgcgcatc tctcaaaagc ctcctgacga agatcatcca 687181 tacggccact ttcgagcgga aacgattgca tcgcttatcg catcgtttat tatgatggtt 687241 gtcggactgc aagtgctgtt cagcgccgga gaatctattt tttctgctaa acaagagacg 687301 ccagatatga ttgcggcttg gacggcagcg ggcggggcag tcctgatgct gatcgtttac 687361 cggtacaata aaaggctggc caaaaaggtg aagagccagg cgctccttgc tgcggctgct 687421 gataataaat cagacgcatt cgtcagtatc ggcacattta tcggcattgt ggctgctcaa 687481 ttccatcttg cttggattga tacggtcact gcgtttgtga tcggtctgct tatttgcaag 687541 accgcatggg atatctttaa agagtcatct cactctttga cagatggatt cgacataaag 687601 gacatttccg cttataaaca gacaatcgaa aaaatctccg gtgtgagccg tttaaaagac 687661 ataaaagcaa gatacttggg cagtacggtt catgttgatg tggtggttga ggtatcggca 687721 gatttaaata ttacggaaag ccacgatata gccaatgaaa ttgagcggag aatgaaggag 687781 gagcatgcga ttgattattc gcatgttcat atggagcctt tagaacaaaa ataatggagc 687841 ttcctgtcac aggaagcttc agcgtgtcga caaaccctcg cattcgttgt caggtctgcg 687901 cttcggtgct cacgaattag aacattcgct ccgctcctat gctcgtcctt cctagacttc 687961 aagggttttc aatcacgctg aaaagatgac aaaaccctaa aatgaaagcc attttaggat 688021 tttgtcaaca atctggagct tcctgccaca ggaagctttt ttgtgtgttt tggccagctt 688081 tattggtaac aatttgctag aatcgttttt ttatacagat tgctttttgt ggtaaagtta 688141 ggttacatta tgatgaattt tgtagatgac taggaggaaa ataatggcat atcaagaaga 688201 cctgcatcct ttgctgggga aagcagttga acatattaat agagtaatgg ttggaaaacg 688261 agacatcgcc atactcagct tagcagccct tcttgccaaa gggcatgtgc tgcttgagga 688321 tgtacccgga gtcggaaaaa cgatgatggt ccgcgcgctg gcaaagtcaa tcggcgccga 688381 tttcaaaaga atccaattca ctccggattt gctgccatct gatgtaacag gggtatctat 688441 ctataatgcg aaaacgatgg aatttgaata tcgtcccggc ccaattatgg gaaatatcgt 688501 gctggcagat gaaatcaacc gtacctctcc gaagacacag tcggctttgc tcgaagcgat 688561 ggaagagggg agcgtcacgg tagatggcca tacgatgcag cttgccgatc cgttttttgt 688621 gatggcaacg caaaacccgg tcgaatatga agggacctat cctttgccgg aagctcagct 688681 tgaccgtttt ttattcaaac ttcggatggg ttatccgtcc tttaatgaag agcttgacgt 688741 cttatctctt caggaaaaaa gccatccgat tgagacgctt gagccggtta ttgcaaaaga 688801 agacttcatc tttttacaga gggaagtgca aaatgtccgt gctgatgaca gcattaagga 688861 atatatcgtt gaaattgtgc agaaaacgag acagcatcct tctgttcaat taggcgtcag 688921 tccgcgcggc tcaatcgccc tcatgaaagc ggcacaggca tacgcgctgc tgcatcatcg 688981 cgactatgtc ataccggatg atattcaata tttagctcct ttcacgctgc cgcaccggat 689041 gatgcttcat cctgaggcaa aatttgaagg gattcaggca gaagcgatcg taagggagat 689101 catgtcagct gtgaaggtgc cggttcaaag gtcggcggtc cgctgatgaa taagaaatgg 689161 caatggctcg tatatggttg gaagctgatt atattaactt tattgacggc tgctgttttt 689221 tcttatgcga tgtttcaggg cggctttgtc agctggtttt tgttttacgc gtttctccct 689281 tttgtcttgt atgccgggct gttggccttg tatccgctcc gttcttttca ggcttcaagg 689341 caaatggata aaacacaatt gcatgcgggg gacaggctgg gcgtaacggt tacgctgaga 689401 agaaagctgc catttccgct gatgtatatg gtgattgaag attgcctgcc agaaggtatc 689461 gagtcattaa atcgagacgg agccgcggcc aaacggctcg tttttccttg gtttaaacgg 689521 agcatgacga tgtcgtatga attagctcgg gtaccgcgcg gagagcatca ctttcattct 689581 gtcagggtgc gaaccgggga tgttcttggc ttgattgaaa aaacagcatt ttttgagctg 689641 gatgatacct tgtttgttta tccattctat cagcgttttt cctatcaggt gaatgagagg 689701 catcaggaag acggtgtaag cggttcttct cctattcatc agcaccattc ctcagtcgca 689761 gcaagtgtgc ggaattatca gccgggagac cggtttgctg cgttagattg gaagacatct 689821 gcacggcgga gccagctgat gacgaaggaa tttgagcctt ctcgcagcaa aaatctgttt 689881 ctgctgatgg accgtttttc ctcagacgca ttcgaagagg tcgtttcagt gacagcttcg 689941 attcttcatt ctgttttaaa aaacggcgcg ggtgctggtc tggcttccat cgggaaggaa 690001 aaaaacattt tccctattca ggaaggggat cagcatttta agcacatgct tcggcattta 690061 gccatcgctc attgtgatgc ggcagacccg ataagccgat atgcacggga agagctggga 690121 aagccatctg ttcgccaagc tgatcaagtt gttgtcacgg gacagttaac ggaagatatg 690181 ctgcacctcg cagaaatagg aggcggccgg gttacggtga tactggcaaa agagaaagat 690241 gctgagctct ctcaagctga aaatgtcatg attgaacgca tgatgaaacg ccaaatcaga 690301 gttcggatca tgaggggcgg gcgagtttcg cgtgttgttt agaaagagag gtgactggtt 690361 cacatgccgc acgatgatca caagggaagc cgtttgagct tgctgttatt ttattttctg 690421 gcttttttat tgctgtggga gtggcttagg ccgcttgaca gttttactga aacgaaacat 690481 acaggctttt ttagtgtctt tatcggcttg acgtttctgc tgactttttt caggatgagg 690541 tggtttgtca ccgttccttt ttgtgtcata tttacattga tctcgataca catcctgttt 690601 tatcaaggat ctatattcga cttgagctgg gtcagctctt ttttgcagga tgtctatctg 690661 aatatcacgc tgattcaatc agggcaatgg aatgacatga ttccttcatt tcggaccctg 690721 ctgttttttg tgctgctgtg gctgctggtc tatctcctgc attattgggt gatttaccag 690781 agaagaattt tgtttttctt tttgatgaca gtagcgtata ttacgattct tgataccttt 690841 acgccatatg atgccacttt tgccgtaatc cgtatcgtgc tgatcggctt ctttatgctg 690901 ggccttttat acttggaacg cattaagctg atggaaagaa tcacactgcc aaaaacatct 690961 gtcctgaaat ggtttcttcc tttatctgta ttggttttgg ctgcaacggg attcggactc 691021 gccgctccaa aatcagagcc ggcttggcct gatccggtgc cttttcttaa aaaaatcact 691081 catcaagacc gcgtgtctgc aggggaaagc aaaatcggat acgggaatca tgatgaatca 691141 ctcggcggcc cgttccagca ggatgctaca cctgttttta catggcaggg aaaagagcgt 691201 acgtatttcc gtgtggaaac gaaggacacg tataccggaa aaggctggat tgaaacagac 691261 acaggcatgt cgtatcagct tagcaatgga aaagttgaaa atctgtggtt tgaccataag 691321 gttgcgacag agcgccgcac cgtccgtgta aaagtcgata agcactacgg gtataaccat 691381 ctgatgtatc cgattggtgc ggaaaccatt cagccaaagc aggctgtctc acttgaaatg 691441 aacggcaaca cggagcaaat ttctccgatc agtgaacaag ccggtgaaat cagaaatatg 691501 gggaattata cagtaacgta caattccccg gtctataagc tggatgaact gagaaaggta 691561 aaagtgagaa aaaacagtga ggagtacaca ttcagcgatc gctacatgca gcttccagat 691621 tcactgccag agcgggtgag aacccttgcg atcaaactga ctcaggatca cgacaatatg 691681 tttgataagg tgaaagcggt tgaggactat ttagggtcaa atgcgttcac atatgaaaca 691741 gaaaacgtga ccattccgaa gaatgatgaa gattatgtcg atcaatttct ctttgaaacg 691801 aaaatgggtt attgtgataa cttttcttcc gccatggtgg tgctcttgcg ctcggccggc 691861 attccggccc gctgggtaaa gggttatacg tccggcgaat acaaagaagc agggaacaaa 691921 aatggcagca tttacgaagt gacaaataac aatgcccatt cctgggtaga ggtgtatttc 691981 ccggaacagg gctgggttac atttgagccg actaaagggt ttacaaatcc ggctcaattt 692041 acatcttctg acacaaaaga ctctggcagc gatagcagca gctcgccgaa gaaagcaaaa 692101 gagaaacaga aagaagagaa aaaacagccg caaaaagagg aaaaacaaaa ggaaaagcgg 692161 gagccagctg tttctaaaaa gccgtccgct tcgcatacta atgccggtgc gggcttgtat 692221 gcagcgcttg cggttcttgc agtcctcctg gtggcagctg tattgctgta tgttttccgc 692281 tcgttatgga ttcctgtttt cgccgtgagg aaattgaagc ggcgcagtga tcagcacgcg 692341 ttttttgagg catatggcgc gctgctgaaa caactgaaga gaaaaggact gccgaaacga 692401 gacagtgaaa cgctgcgtga ttatgcaaaa cgaattgatg aaaaatacga catagaagac 692461 atgtcaaagc tgacattaag ctatgaaagg gcgctttaca gaaatgaaga ttcttcggcg 692521 ctatggaatg attcgagaga gttatgggaa aatttaatta aaagaagatg gtcttgaccg 692581 cttatcgacg tgttgttaga attagtgaat attatcggag tctgggagcg agttggcctg 692641 actccggcaa acggccttgc caaagagggc ggagcgagct tcatatctgt cctcgttttt 692701 ttctgtgtca aaaaacttag aggagattag gtgacaacca tgacaaagtt agtgaatgaa 692761 atgattcttg tccttgattt cggcagtcag tataaccagc tgattacacg ccgtatccgt 692821 gaattcggtg tttacagcga gctgcatcca catacattga cggctgaaga aattaaaaaa 692881 atgaatccaa aaggaattat tttatccggc ggtccaaaca gtgtgtatga tgaaaactct 692941 ttccgctgtg acgagaaaat cttcgagctt gatattcctg ttttgggaat ttgctacggc 693001 atgcagctga tgactcatta ccttggcggt aaagttgaag cggcaagcca gcgtgaatac 693061 ggaaaagcaa acatccgcat cgaaggcaca cctgatttgt tcagagatct tccgaatgaa 693121 caagtggttt ggatgagcca cggcgatttg gttgtagaag ttcctgaagg cttcactgtt 693181 gacgcgacaa gccatcactg cccgaactca gcaatgagca aagcggacaa aaaatggtat 693241 ggcgttcagt tccacccgga agtgcgccac tctgaatacg gcaatgatct tctgaaaaac 693301 tttgtattcg gtgtttgcga atgcgaaggc gaatggtcaa tggagaactt tatcgaaatc 693361 gaaatgcaaa aaatccgtga aacggtcgga gacaaacagg ttctttgcgc gctaagcggc 693421 ggcgttgatt cctctgttgt tgctgttttg attcataaag cgatcggcga ccagctgact 693481 tgtatctttg tagaccatgg tcttctccgt aaaggcgaag ctgagggtgt tatgaaaaca 693541 ttcagcgaag gctttaacat gaatgtgatt aaagtagacg caaaagatcg attcttaaac 693601 aaactaaaag gcgtttctga tcctgagcaa aaacgcaaaa tcatcggtaa tgaattcatt 693661 tacgtgtttg atgatgaagc ggacaagctc aaaggcatcg actaccttgc acaaggtacg 693721 ctttacacag atatcatcga gagcggtaca gcaacggcgc aaacgatcaa atctcaccac 693781 aatgtcggcg gacttcctga agacatgcag tttgagctga tcgagccgtt aaatacgctc 693841 ttcaaagacg aagtgcgcgc gcttggcaca gagctcggca ttccggatga aatcgtatgg 693901 cgtcagccgt tcccaggacc gggactcgga atccgcgttc ttggcgaagt aacagaagaa 693961 aaacttgaaa tcgttcgtga atcagatgca atcttgcgtg aagaaattgc aaatcacggc 694021 ttagagcgtg atatctggca atacttcact gttcttcctg acatccgcag cgttggtgtt 694081 atgggtgacg caagaacata tgattacaca atcggaatcc gcgccgttac atcaatcgac 694141 ggcatgacat ctgactgggc gcgtatcccg tgggatgtgc ttgaagtcat ttcgacacgt 694201 atcgtaaacg aagtgaagca cattaaccgc gtggtgtatg atattacaag taagccgcct 694261 gcgacgattg agtgggaata agaatcaatt aatggaaacc atctttttgg caattttgcc 694321 gggaagatgg ttttatttgt ttattacgaa caaaatccga ttttgcgcga ctattgttcg 694381 ctttttgtat tgttttttca aaatgaactt ggtacaatag acacagaaat caaataagat 694441 gaattcgtat aatcgcggga atatggctcg caagtctcta ccaagctacc gtaaatggct 694501 tgactacgta aacatttctt tcgtttgata taaataaaac acggttattt attcaaactg 694561 aaatccgtct gtagtcaagc gtcccaaaat gtattgggac gttttttatt tggcgttttc 694621 aggacagaat aaatagcaaa gagtgaaggg agtcaaatag cttgaaaacg ttttttcagt 694681 ttgatgagct gggcaccagc tatcgcaatg aaatcattgg cggattaacg acttttttat 694741 ctatggcata tattttgttc gtcaatccga ttacgcttgc tttggagagc gtgaaagatt 694801 ttccggaggc gctgagaatt gaccagggtg cggtctttac ggcgacagcg ctggcgtctg 694861 cagcaggctg tatcttaatg ggattaatag cgagatatcc gattgccatc gcgccgggta 694921 tggggctgaa cgcgtttttt gcgttttctg ttgtccttgg tatgggtatt tcatggcagg 694981 cagctttgtc cggtgttttt atttcaggtc ttattttcgt tgctctttct ttaacaggtt 695041 ttcgtgaaaa aatcatcaac gccattccgc ctgagctgaa attggcagtc ggtgcgggga 695101 tcggcctgtt tattacattt gttggattac aaggttcagg aatcattaca gcgaatcctt 695161 ctacgctcgt cacgatcgga aacattcaca gcggtcctgt gctgttaacg attttcggtg 695221 tgattgtcac ggttatttta atggtgcttc gcgtgaacgc aggcgtgttt atcgggatgc 695281 tattaacagc ggtagccggc atgattttcg gtttggttcc ggttccgact caaattatcg 695341 gcagtgtgcc aagccttgcg ccgactttcg gacaagcgtg gattcacctc ccggatattt 695401 tctctgtaca aatgctgatc gttattttaa cattcttgtt tgtcggattt tttgatacag 695461 ctggtacact tgttgctgtg gcaacacaag ctggtttaat gaaggaaaac aaattgccgc 695521 gtgcgggccg tgcgctttta gctgattcat cttctattgt gatcggtgcc gtgcttggta 695581 cgtctacaac aacttcttac gtggaatcaa gctcaggtgt cgctgcgggt gcccggtcag 695641 gatttgccgc aattgtaaca gggattctct ttttactggc tacgtttttc tcgccgctcc 695701 tatcagtcgt tacgtcaaat gtaacagcgc cggcgcttat tattgttggt gcattgatgg 695761 tggcgccgct tggcaaaatc gcttgggata agttcgaagt ggccgttcct gctttcctta 695821 ccatgatcat gatgccgtta acgtacagca tcgcgactgg tattgccatc ggatttattt 695881 tctatccgat tacaatggtg tgcaaaggaa aagcaaaaga ggttcatcca atcatgtacg 695941 ggctgtttgt cgtatttatc ctgtacttta tcttcttaaa ataaggaatg aaaaaccagc 696001 tgcactggca gctggttttt ttgttgcaaa agataaaacc atttcatacg atataccgtc 696061 atgtagatgt gccgccatgc tttacttaaa tggaaatgac ttgactgttc aggaaggctt 696121 cggtacctta tataagtgtt ttattttctt gctgaatggt attccgccgt atttttttga 696181 taggagttgc tgacatgacg gaagaaagaa aagaaacgtt tgaagaagaa attaaccaga 696241 gtgaaagaat agatgcagat gaagaaccgc tatcgagaat gtccagaaag gcgagccggc 696301 aaagcaagca gaagcaaaaa caaaagcaga aaccgcgcca ggaacgcggt gaatcaactg 696361 ttaaagacaa gcttgcgtct gtttgggcag ccatcaacag atattgcggt tttgcgttct 696421 cgattttaaa atctccggcg aaaactgtcg taacggatgg tttttctcat tataagtacg 696481 gtctgatttc aatgcttata ttcagtatca ttttttcaat tgggaattgg tttcagttaa 696541 aggcaagctg gaatcggccg ctcggtttcg gagaacgcca tcatgctttc tatgacgggt 696601 ttttagttgt tcttgtgtat ttgctgatct ttttcgcggt aatggtcttt gctatatggg 696661 ctgtctcccg ctatatgatg aagcagaagg tgacgttcag agaagcggct gccgtattgg 696721 gttcattgct tgtacccgta attgctgttt caatcctttg gctgatcttt gcgatcgtaa 696781 atatcccaat gctgacagta ctgtttacgg tgctgatctt gttttccatc ttttttatca 696841 tcgcgctgta tgtacagcgt gtgtaccagg cggcacaaga tgcaccaatt gattatatct 696901 attgtgtatt tgcagtagtt gcgatagcgc tgctgtttac ggcagtgact tggccgttta 696961 tttctgaata tattacggcg tcgttgattc cgctttaatg aaaaaaccgg ctaatcctag 697021 ccggtttttt tatgtcacac tttttacaaa tatatctaaa aaacatagtt gatttgtagg 697081 attaacccgt gtatgatggg gaaaatgctg aaaacgtcca gcgcaaaaac ctttatgttt 697141 aaggaggatg atggacatgg ctgatgtact tcgccgagca attaaccaaa agaagcaatt 697201 tttaaaaacc aaattactgc tctcggaatt ttatcaagga agaggggaac agcttgctga 697261 ctacacgctg agtgagcttg agaaagaata caagtccctt cagaaaatga aaaaagagat 697321 ctgacaatag atataaagag gtgagtctgc tgaaaagcgg gcttttttgt tttgattttg 697381 aaaaggcgag aaagagggta aactactact gttcaacaca taaaagcgtg tcgaaatatt 697441 ttgcttaagc ttacgggcga agctgattgt aaacggctca tttctctagt agaatatgaa 697501 tgctttgtgc aagctgaaga gtagggggat gaataaaatg atgcaaacca tcttatcaaa 697561 tgggatagcc atggttctca taattctcat tattaatatt gtctatgtgt cattttttac 697621 gataagaatg attttaacgc tgaaaggaca gcgttattta gcggccggca tcagtacgat 697681 tgaaatactg gtttatgtga caggactgag tctggtgctc gataacttag accagattca 697741 aaatgtgatc gcgtacgcgc tcggttacgg tcttggcgta attgtcggca tgaaaataga 697801 agaaaaattg gcgcttggct atattatggt caatgtgatt acgaaggagc tcgatcttga 697861 tcttccgaag cagctccgtg aaaaaggcta cggcgtgaca aactgggtgg caggcgggct 697921 tgaaggcgac cgcacagccc ttcagatcct gacgccgaga agatatgaac tccagctata 697981 tgatacgatt aaaacacttg attcaaaagc ctttattatt gcgtacgaac caaaaacaat 698041 ccacggcggc ttctgggtca aagcggtgaa gaagaggaga attaaagaat aatggcaaag 698101 ccgaagaaga aaaagtttga agtgacagag cagcaaacga ttgatgcggt gcttcagcaa 698161 atgaaagaag aaggatatct gcctgtaagg cgaatggaag agcctatttt tatggaaaaa 698221 aaggaaaatg ggtcaattca gatcgttccg tgcgggaaaa aaatcgtatt tgaagggaaa 698281 ttgatctaaa acacgaacat tagtagaatg aatttttgta tcgttcgata atatcgttga 698341 cattatccat gtccgttgtt aagataaaca tgaaatcaaa acacgacctc atataatctt 698401 gggaatatgg cccataagtt tctacccggc aaccgtaaat tgccggacta tgcaggaaag 698461 tgatcgataa aactgacatg gatatatcgc agaagcgaac gactgacgat acatgtacca 698521 tgcccggttt gtattgcttc ctcataagtg caatgcagag cgggtatttt ttattttctg 698581 aaaacaaaag cattagaagg tggggaacag aatgcagccg ctagtaggaa tcatcatggg 698641 aagcacttcc gattgggaga caatgaaaca cgcatgcgac atacttgacg aactcaatgt 698701 tccgtacgaa aaaaaggtcg tttccgctca ccggacgcct gatttcatgt ttgaatatgc 698761 tgaaactgct agagaaagag gcatcaaggt gattattgcc ggtgccggag gagcggcgca 698821 tctgccaggg atgacggctg cgaaaacaac actgccagtc attggagttc cggttcagtc 698881 caaggcgctg aacggaatgg attcacttct ttccatcgtc caaatgcctg gaggcgtgcc 698941 tgttgcgaca acatccatcg gcaaagcggg tgctgtgaac gcaggcctgt tagcggcgca 699001 aattttgtca gcatttgacg aagaccttgc ccgtaagctg gatgagagaa gagaaaatac 699061 aaaacagaca gtgttagaaa gcagtgatca gcttgtctaa acaaatcatc tatccgggag 699121 ctgtaatcgg cattatcggc ggcggccagc ttgggaaaat gatggctgtg tccgccaaac 699181 aaatggggta taaagtcgcg gtcgttgatc cggtgaaaga ttcgccgtgc gggcaggttg 699241 cggatgtcga aattaccgct cattataatg accgtgaagc gattcgaaaa ttggctgaaa 699301 tcagcgatat catcacatat gagtttgaaa acatcgacta tgatgcgctg cattggctaa 699361 aagatcatgc gtatctcccg caaggaagtg agctgctgct tattacccaa aaccgtgaaa 699421 cagagaaaaa agcaattcaa tccgcgggct gtgaagtcgc accgtacagc atcgtcaaaa 699481 caaagaatga attgaaacag gcagtacagg agctcaggct tccggcagtg ctgaaaacat 699541 gccgcggcgg gtacgacggc aaaggccaat ttgtgataaa agaagaggcg caaatggagc 699601 aggcagccgc tctgttagaa cacggaactt gcattcttga aagctgggtt tcttttaaaa 699661 tggaactgtc ggtgatcgtc gttagatcgg taaacggtga aatttcaaca tttccgacag 699721 ctgaaaacat tcaccacaac aatattcttt tccaaagcat cgtgcccgca cgggtagaga 699781 aagggattca gcagaaggct gctgatctcg cagttaagct tgcagatgag cttaaccttg 699841 tcggaccgct tgctgttgag atgttcctga cagaggacgg agagcttttg gtcaatgaac 699901 tggcgccaag accgcacaat tcagggcatt atacgctgga cctttgcgag acgagccagt 699961 ttgagcagca tatcagagcg gtatgcgggc ttccgcttgg gaagacagat ttgctgaagc 700021 cgggcatgat ggtgaatctt ctcggcgatg aagtgaagct tgttgaggaa gacccggagc 700081 ttttaaaaga ggcaaagcta tatatatacg gaaaacatga aatcaaaaaa ggccgcaaaa 700141 tggggcatat tacatttatg aagcagcctg aagacgaatg gattcaggag atcacaaata 700201 aatggatgaa tagagacgga ggacaagcag aatgatcgaa cgttattcaa gacctgaaat 700261 gtccgcgatt tggacggatg aaaacagatt tcaagcatgg ttagaggttg aaattcttgc 700321 ctgtgaagcg tgggcggagc ttggcgtcat tccgaaagaa gatgtaaagg ttatgcgcga 700381 aaacgcgtca tttgacatca accgcatttt agaaatcgaa aaggacacgc gccatgacgt 700441 tgtcgctttt acgcgcgctg tatccgaatc actgggcgaa gaaagaaaat gggtgcatta 700501 cggcttaacg tcaactgacg ttgttgatac ggctctttcc tacttattaa aacaggcaaa 700561 cgatattttg ctcaaggatc ttgagagatt tgttgacatt ataaaagaaa aagcgaaaga 700621 acataaatac acagtcatga tggggcgcac acacggcgta cacgctgagc ctacaacatt 700681 cggcttaaaa cttgcgcttt ggcatgaaga aatgaaacgt aatcttgagc gcttcaaaca 700741 agcgaaagca ggcatcgagg ttggaaagat ttccggtgct gtcggcacat atgcgaacat 700801 tgatccattt gttgaacaat atgtctgtga gaagctcgga ttgaaagcag caccgatttc 700861 cactcaaacc cttcagcgtg accgccatgc tgactatatg gcaacacttg ctttgatcgc 700921 gacaagcatc gagaaattcg ctgtggaaat ccgcggactg caaaagagtg aaacacgtga 700981 agtagaggaa tttttcgcga aagggcaaaa gggttcatct gcaatgccgc ataaacgaaa 701041 tccgattggc tctgaaaaca tgacaggcat ggcgcgcgtg atccgcggct acatgatgac 701101 agcttacgaa aatgttccat tatggcatga gcgcgatatt tctcattctt cagcagaacg 701161 aattattctt ccggatgcga caattgcgct gaactacatg ctgaaccgct tctccaacat 701221 cgtgaagaac ttaacggtct tcccggaaaa catgaagcgc aacatggacc gcactctcgg 701281 ccttatctat tctcagcgtg tgctccttgc tttgattgac acaggcctga ctcgtgaaga 701341 agcctatgat acagttcagc cgaaagcaat ggaagcgtgg gaaaaacaag tgccgttccg 701401 cgagcttgtg gaagcggaag agaaaatcac gtcacgtctt tctccagaaa aaattgctga 701461 ctgctttgat tacaattacc atctgaaaaa tgttgatctg atctttgaac gtttaggttt 701521 agcatagaag aagcttttag cggcttcttc taagccgccg cagtttgaaa attcccaaca 701581 ttcgggttag gaggccttcc gtgaatattg tgaagaatga acttttatac gaaggaaaag 701641 caaaaaagat ctacaaaacc gatgacgaaa acacgctgta tgtcgtgtat aaagactccg 701701 ccactgcctt taacggcgag aaaaaagcag aaatcagcgg aaaagggcgc ttaaataatg 701761 aaatttcaag cctcattttc aaacaccttc atgctaaggg cattaacaat cattttatcg 701821 agcgcatttc ggaaacggag cagctcatta aaaaggtaac gattgtgccg cttgaagtcg 701881 tggtaagaaa tgttgtggca ggaagcatgt ccaaacgtct cggcattcca gaaggcacgg 701941 agcttgagca gccgattatc gagttttact acaaggatga cgcgctgggt gatccgctca 702001 tcacagaaga tcatatttgg cttttgaagg cggcgactcc tgagcaggta gaaaccatta 702061 agtccattac aacaatagta aatgaagagc ttcaaagcat cttcgacgat tgtcatgtca 702121 gattaataga tttcaagctt gaattcggtt tagatgcaga agggcaagtg cttttggcgg 702181 atgaaatatc tcctgacaca tgccgcttgt gggataaaga aacgaacgaa aagctggaca 702241 aagatttatt cagacgcaat ctgggaagct taaccgacgc atacgaagag attttcaata 702301 gactgggagg cattcatcat gtataaagta aaagtttatg tcagcttaaa agaaagtgta 702361 ctagatccac aagggagcgc tgtccagcat gccttgcaca gtatgactta caacgaagtt 702421 caagatgtgc gcatcgggaa atacatggag cttaccattg aaaaatctga ccgtgatctt 702481 gacgtgctag tgaaagaaat gtgcgaaaaa cttcttgcga acacagtgat tgaagattat 702541 agatatgagg ttgaggaggt agtcgcacag tgaaatttgc ggtgattgtg ttacccggct 702601 ccaactgtga tatcgatatg tatcatgctg taaaggatga gctcggccat gaagtggaat 702661 acgtctggca tgaggaaaca agccttgacg gcttcgacgg cgtgttaatt ccgggaggat 702721 tttcttacgg cgattactta agatgcggcg ccatcgcccg atttgcgaat attatgccag 702781 ctgtcaaaca agcagcggct gaaggaaaac ctgttcttgg cgtctgtaac ggattccaga 702841 ttttacagga gcttgggctg ctgccaggcg caatgagacg caacaaagat ctgaagttca 702901 tttgccgtcc ggttgaattg attgttcaga acgacgaaac cttattcaca gcttcctacg 702961 aaaagggaga atcgattaca atcccggttg cccatggtga agggaatttc tactgtgatg 703021 acgagacgct tgctacatta aaggaaaaca atcaaattgc tttcacatac ggctctaata 703081 ttaatggaag tgtcagcgac attgccggtg tcgtgaatga gaaaggcaat gtattaggca 703141 tgatgcctca ccctgagcgc gcggtcgatg aactgcttgg aagcgccgac ggtcttaaat 703201 tgttccagtc tatcgtgaaa aattggaggg aaactcatgt cactactgct tgaaccaagt 703261 aaagaacaaa taaaagaaga gaaactgtat cagcaaatgg gtgtcagtga tgatgagttt 703321 gcattgatag aatccattct tggaagattg ccgaactaca cagaaatcgg aattttttct 703381 gtcatgtggt ctgagcattg cagctataaa aactcaaagc cgattctgcg taaattcccg 703441 acaagcggcg agcgtgtgct gcaggggccg ggggaaggcg ccggaatcgt tgatatcggt 703501 gataaccaag cggttgtgtt caaaattgaa tcacataacc acccatcagc tctcgagcct 703561 taccaaggcg ctgcgactgg cgtaggcgga attatccgtg atgtattctc aatgggtgca 703621 cgcccaatcg ctgtattgaa ctctcttcga tttggtgaac tgacttcacc ccgcgtgaag 703681 tacttgtttg aagaagtagt agcgggtatc gccggatacg gcaactgtat cggcatcccg 703741 acagtcggcg gagaagtgca gtttgacagc agctatgaag gaaatccgct cgtcaacgca 703801 atgtgcgtcg gtttaatcaa ccatgaagac atcaaaaaag gccaggcaaa gggtgtcggc 703861 aacacagtaa tgtacgtagg agcgaaaaca gggcgtgacg gcatccacgg cgctacgttt 703921 gcttctgaag aaatgtcaga ctcgtctgaa gaaaagcgtt ctgctgtcca agtcggcgat 703981 ccgtttatgg agaagctttt gcttgaagca tgtctggaag tcatccaatg cgacgcctta 704041 gtcggcattc aggatatggg agctgccggt ttaacaagct caagtgcaga aatggcaagt 704101 aaagccggtt ctggcattga aatgaatctt gacctgattc ctcagcgcga aacaggcatg 704161 accgcgtatg aaatgatgct ttctgaatca caagaacgga tgcttttggt tattgagcgc 704221 ggacgtgagc aggaaatcat cgatattttt gacaagtatg atcttgaagc ggtttctgtc 704281 ggacatgtga cagatgataa aatgcttcgc ctgacacata aaggagaggt tgtgtgcgag 704341 ctgcctgttg atgccttggc agaagaagca ccggtttacc ataagccttc tcaagagcct 704401 gcttactatc gcgagttttt ggaaacagac gttccggctc cgcaaattga agatgcgaat 704461 gaaatgctga aggcccttct tcagcagccg acgattgcga gtaaagagtg ggtttatgat 704521 cagtatgact acatggtgcg cacgaataca gttgtcgctc ctgggtctga tgctggtgtt 704581 ctcagaatcc gcggaacgaa aaaggcgctg gcgatgacga cagactgtaa cgcgcgttat 704641 ctctatcttg atcctgaagt cggagggaaa attgctgtcg ctgaagcagc gcgcaacatc 704701 atttgctcag gcgcagaacc gcttgcggtg acagataacc ttaacttcgg aaaccctgag 704761 aagccggaaa tcttctggca gatcgaaaaa gcggcagacg gcataagcga agcgtgcaat 704821 gttctcagca ctccggttat cggcggtaac gtatcgcttt ataacgaatc aaacggcacg 704881 gcgatctatc cgacaccagt tatcggcatg gtcggcctaa ttgaagatac agcgcacatt 704941 acaacacagc atttcaaaca agcaggagat ctcgtatacg tgatcggcga aacaaaacca 705001 gagtttgccg gaagcgagct gcaaaaaatg acagaaggcc gtatttacgg caaagcgccg 705061 caaatcgatc ttgatgtaga gctgtctcgt caaaaagcac tgcttgacgc gattaaaaaa 705121 ggcttcgttc aatctgcgca tgatgtgtct gaaggcggct taggcgtagc gattgcggaa 705181 agtgtcatga cgacggaaaa ccttggcgct aatgtgactg tagaagggga agcggcgtta 705241 ttattctctg aatctcaatc tcgcttcgtc gtttcagtga aaaaagaaca tcaagctgcg 705301 tttgaagcaa ctgtcaaaga tgcagttcat attggtgagg taacagctga cggaattctg 705361 gcgattcaaa accaagacgg acaacaaatg attcatgcgc aaacgaaaga gcttgaacgc 705421 gtatggaaag gagctatccc atgcttgctg aaatcaaagg cttaaatgaa gaatgcggcg 705481 tttttgggat ttggggacat gaagaagccc cgcaaatcac gtattacggt ctccacagcc 705541 ttcagcaccg aggacaggag ggtgctggca tcgtagcgac tgacggtgaa aagctgacgg 705601 ctcacaaagg ccaaggtctg atcactgaag tatttcaaaa cggcgaactc agcaaagtaa 705661 agggaaaagg cgctatcggg cacgttcggt acgcaacggc tggaggcggc ggatacgaaa 705721 atgttcagcc gctcctcttc cgttcccaaa acaacggcag cctggcgctt gctcataacg 705781 gaaatcttgt caacgccact cagctgaagc agcagctcga aaatcaaggg agcatctttc 705841 aaacctcttc ggatacagag gttttggctc acctgatcaa aagaagcgga cacttcacgc 705901 tgaaggatca aattaaaaac tcgctttcta tgctgaaagg cgcctacgcg ttcctgatca 705961 tgaccgaaac agaaatgatt gtcgcacttg atccaaacgg gctgagaccg ctatccatcg 706021 gcatgatggg cgacgcttat gtggtcgcat cagaaacatg cgcatttgac gtcgtcggcg 706081 caacgtacct tcgcgaggta gagccgggag aaatgctgat cattaatgat gaaggcatga 706141 aatcagagcg tttttccatg aatatcaatc gttccatttg cagcatggag tacatttatt 706201 tctccagacc agacagcaat attgacggta ttaatgtgca cagtgcccgt aaaaaccttg 706261 ggaaaatgct ggctcaggaa tccgcagttg aagctgacgt cgtaaccggg gttccggatt 706321 ccagtatttc agcggcgatc ggctatgcag aggcaacagg cattccgtat gagcttggct 706381 taatcaaaaa ccgttatgtt ggcagaacgt ttattcagcc gtcccaggct ctgcgtgagc 706441 aaggcgtcag aatgaagctg tctgcggtgc gcggggttgt agaaggcaaa cgcgtcgtga 706501 tggtggatga ctctatcgtg cgaggaacaa ctagccgccg gattgtcacg atgctaagag 706561 aagcgggtgc gacagaggtg catgtgaaaa tcagttcacc gccgatcgct catccgtgct 706621 tttacggcat tgacacttcc acacatgaag aactgatcgc gtcttcgcat tctgttgaag 706681 aaatccgtca ggaaatcgga gccgataccc tctcattttt gagtgtggaa gggctgctga 706741 aaggcatcgg cagaaaatac gatgactcga attgcggaca gtgtctcgct tgctttacag 706801 gaaaatatcc gactgaaatt taccaggata cagtgcttcc tcacgtaaaa gaagcagtat 706861 taaccaaata aaacttgaaa aatgacataa aggcagcgca gttcggctgc ctttctcttt 706921 ctgccctcgt tcggggagat attttgaaaa gcgccttaaa ggagtgaata ggatgtctga 706981 agcatataaa aacgcaggag ttgacatcga agccggatat gaagctgtaa aacgaatgaa 707041 aaaacacgtg gagcgcacga aacggcttgg cgttatgggc agccttggcg gttttggcgg 707101 catgtttgac ctgtctgagc tttcttatca aaaaccagtt ctcatttcgg gaacggacgg 707161 tgtcggcaca aaattaaagc tcgctttttc catggataag catgacacga ttggcgtgga 707221 tgctgttgca atgtgtgtca atgacgtgct ggcacaaggt gcagagccgc tgtttttcct 707281 cgattattta gcggttggca aagcggaccc agtgaaaatt gaacagattg tacaaggtgt 707341 tgcggaaggc tgtgagcagt caggttcagc cttagtcggc ggtgaaacgg ctgaaatgcc 707401 ggggctctat acagctgatg aatacgatat tgccggtttc tcagtcggag tggcagaaaa 707461 ggacgaaatc gtgactggag aaaaaattga agagggccat ctgttgatcg gcctcagctc 707521 cagcggcctt cacagcaacg gcttttccct tgtcagaaaa gtgcttctgg atgatgcgga 707581 gctggacctc gatacaacat atgagccgtt tgaacgcccg cttggcgagg aattgcttga 707641 accgacaagg atttacgtga agcctgtgct tgccgcggtc aaaagcggaa aaatcgacgg 707701 catggcgcac gtgacaggcg gaggatttat tgaaaatatt ccgcgtatgc ttccggaagg 707761 cttaagtgcg gaaattgatc atggctcatg gccgatcccg ccgatttttt ctttcttgca 707821 agagtacggc aagctaaagg aagaagacat gttcaacgtc tttaatatgg gtatcggttt 707881 tgttttggca gtcaaagaag agcatctgac agatgtgatc ggaacgcttg aaagccatgg 707941 cgaaaaagcc tatttaatcg ggcgtgtgaa aaaaggtgaa ggcgtcacat tcggcggtgc 708001 ggcactttca tgaaaaagtt tgcggtattt gcatcaggaa acggttcaaa cttcgaagcc 708061 atcgtcacgc gtttgaagga ggagaactgg gatgcgtcag cagcgctcct cgtttgcgac 708121 aaaccgcagg cgaaagtcat cgaacgggcg gaagcattcc acattccatc cttcgcattt 708181 gagccgaagt cttatgaaaa caaggctgca tttgaacaag ccatcattga acagcttcgt 708241 cttcacgagg ttgaattgat tgctcttgcc ggctatatga ggctgatcgg tgatacgctc 708301 cttcaagcat atgggggaaa aatcattaac attcacccat cgcttcttcc ggcgtttcct 708361 ggaatcgacg cagtcggaca ggcgttccgg gcgggtgtga aggtggccgg aatcaccgtg 708421 cattatgtcg atgaaggaat ggatacaggt ccgatcatcg ctcaaaaggc aatcgaaatt 708481 gatgaacatg atacattgga aacaatcgaa cagcgaattc acaagcttga gcataaatgg 708541 tatccgagtg tgattaaaca gctattagga ttaaataaca gaggtgaaaa ggcatgacca 708601 ttaaacgtgc attaatcagt gtttcagata aaacaaatct cgttcctttc gtaaaagaac 708661 tgacagagct tggcgttgaa gtcatctcca caggcggaac gaaaaagctt cttcaagaaa 708721 acggtgtgga tgtgatcgga atttctgaag tgacaggctt tcctgaaatt atggacggcc 708781 ggttaaaaac cctacacccg aatattcacg gcggccttct ggcggttcgc ggcaatgaag 708841 agcatatggc gcagatcaat gaacacggga ttcagccgat tgacctcgtt gtcgtcaacc 708901 tctatccatt taaagaaacg atttctaaag aagacgtcac gtatgaagaa gcgatcgaaa 708961 atatcgacat cggcggacct ggcatgctgc gcgcggcatc aaagaaccat caggatgtca 709021 cggttatcgt cgatccggcc gattacagcc cagtgctaaa tcaaatcaaa gaagaaggca 709081 gcgtatctct tcagaaaaaa cgcgagctcg cggcaaaagt attccgtcat actgcggcat 709141 atgatgcact gatcgctgac tatctgacaa atgttgtcgg tgaaaaagaa ccagagcaat 709201 tcactgtgac atttgagaaa aaacaatcgc ttcgctatgg agaaaacccg catcaggaag 709261 caactttcta tcaaacagct cttcctgtca aaggctccat tgcgcaagca gaacagcttc 709321 acggaaaaga gctttcttac aacaacatta aagacgcgga tgctgcagtt caaatcgttc 709381 gtgaattcac tgaaccggct gctgttgctg tgaagcatat gaacccgtgc ggcgtgggaa 709441 caggaaaaac gatcgcagaa gcgtttgaca gagcgtttga agcggataaa acatctatct 709501 tcggcggcat tatcgcgctg aaccgtgaag tggacaaggc aactgccgaa gcgcttcaca 709561 acattttctt agaaatcatc attgcgcctt cattcagcca agaagcgctc gacgtcctga 709621 ctgcgaagaa aaatctccgt ctgctgacgc ttgacgtatc cgccgctgtt caaaaggaaa 709681 aacagctgac atccgttcaa ggcgggctgc tgattcaaga tttagatatg cacggcttcg 709741 atgatgctga gattagcatt ccgacaaaaa gagagccgaa cgagcaagag tgggaagact 709801 tgaagcttgc ttggaaagtc gtgaagcatg tgaaatcaaa tgcgattgtt ctcgcgaagg 709861 acaacatgac agtcggcgtg ggagcaggcc aaatgaaccg cgtcggatcg gcaaaaatcg 709921 caatcgagca agcaggggaa aaagcgaagg gcagcgcgct cggttcggat gcatatttcc 709981 caatgccaga tactgtcgaa gaagcggcaa aagcgggcgt tacagccatc attcagccag 710041 gcggatcgat ccgagatgag gattccatca aaaaagcgga tgaatacggc attgccatgg 710101 tattcaccgg catcagacac ttcaaacatt aaggggatga aaacgacgtg aatgtattaa 710161 ttatcggtaa aggcggaaga gaacatacgc tggcgtggaa ggcagcgcaa agcagcctcg 710221 tcgagaatgt atttgccgct cccggaaatg acggcatggc agcttccgct cagcttgtaa 710281 acattgagga aagcgaccac gcagggcttg tctcatttgc aaaacaaaat caggtcggcc 710341 tgaccattgt cggccctgag gttcctttaa ttgaaggtct ggtggatgaa ttcgaaaaag 710401 cgggcttaca tgtgttcggt ccgtcaaaag ctgcggcgat catcgaagga agcaaacagt 710461 tcgctaagga tttaatgaag aaatacgaca ttccgaccgc agaatacgag acgtttacat 710521 cctttgatga ggcgaaggca tatgtgcagg aaaaaggtgc tccgattgtg ataaaagcag 710581 atggacttgc agctggaaaa ggcgttactg tggctatgac agaggaagaa gcaattgcgt 710641 gcttgcatga ctttcttgaa gatgaaaagt tcggtgatgc gagcgcgtcc gttgtcattg 710701 aagaatatct ttctggtgaa gaattttctc taatggcctt tgtcaaaggg gaaaaggtgt 710761 atccgatggt gattgcccag gatcacaagc gggcgtttga cggagacaaa ggcccgaata 710821 caggcggcat gggcgcctac tcgccagttc cgcaaatttc ggaagaaacg gtccgccatg 710881 ctgtagaaac gatcgttaag ccggctgcaa aagcaatggt acaagaaggc cgttccttca 710941 ctggcgtttt gtacgctgga ttgatgctta ctgaaaacgg ctcgaaggtc attgaattta 711001 atgcccgttt cggcgatccg gaaacacagg tcgtgcttcc gcgcatggaa tctgatctgg 711061 tacaggtgct tcttgatctt ttagatgata aggaagttga cttaagatgg aaggataccg 711121 cggcagtgag tgttgtgctt gcatcagaag ggtatccgga aagctatgca aaaggcacgc 711181 cgatcggcag ccttgcagca gaaactgagc aggtcgtggt cttccatgcc ggaacgaaag 711241 cagaaggtgg agagttcgtt acaaacgggg ggcgcgtcgc caatgtgacg gcttttgatg 711301 aaacgtttga agcggctaga gaccgagtgt acaaagcggt tgatgaaatt ttcaaaccgg 711361 gactcttttt cagaaaagac attggggcac gcgctttaaa ggctgcccaa aaataagtga 711421 ggaaaacccg cagaatagct gcgggttttt tgttatcaaa aagcgggatg gcagctagaa 711481 gaagaaagca caacgagcgt ggttggtttt ccatgggcca tcgaggtgtc aataaaatcc 711541 tcaagcgtat gtaccgattc agtcacgacc tttgtcacat agctgtacat ccccgtgatg 711601 cggtggtttt ctgctacatc aggatgcgat gttgcaaagg cggcgtagtg cttgcagctt 711661 ttcggctcca tgagaataaa agcggtgaca tgcttgttta gtttttcgta acagatattc 711721 gcgctgtagc cggtaatcac tcctttgtct tccagcttcc tgacacgctc cgccgcgctt 711781 ggcgagctga gtccgacaag ctttcccagc tcaaccatcg ttaatctgcc gtttcgctgc 711841 aaatgcgaga gaatctgaag gtctgtatcg tccatttgtc tggctccttt acatatttag 711901 gcgaatgaat gaaaattcct ttgatcgtaa ggtaatgctg ttgatttaac ttcattgtag 711961 catatggatg ccgtcttatt ttttctataa taaagccatc aatcagagag ggggcatcat 712021 gttgccagaa ttgcagcgct ctattacttg gatacaaggg acggcgttaa cgattggggc 712081 ggttttagga tgcgggatat taatcctgcc gtctgtcacc gcggacacgg ccggccccgc 712141 ttctttattt gtttgggtgt tcatgtcctt cttatccttt tttcttgtcg gcacgctggc 712201 ccggcttgtg aaaatagcgc ctagcgcggg aggaatcacg gcttatgtgc agctggcctt 712261 tcagaaaaaa gccggggcta ttttgggctg gatcatgtta gggtccgttc cgatcggcgt 712321 tcccatcatc gctttgactg gcgcgcatta cgtcagttac atcacagagg cggccgattg 712381 gcagattaca ttgattgctg gttgcatgct ggctatatct attttgcttc atatgagagg 712441 gattcaacta tcagcaaaca ttagtacact cgttatatgt gtcatcgtat ttctgcttgt 712501 cacttctatt gctgtgtcat tgccacacgt cacgatagca gaattcaagc cgtttcttcc 712561 gcatggctgg tctgccgctg gatctgtttc tgttatgatt tttttctctt ttgtaggctg 712621 ggaaatgatt accccgttgg ctgaggaatt tcatcgtcct gaaaaagatg tcccgctcag 712681 cttgtttttg gcagcgtctt gtgtggcggg gctgtatatc atgctgtcat ttgtgaccgt 712741 gggtactcat tcatatggag agaatggaga aattgcatcg cttgccatgc tcatttcaaa 712801 aggagcagga gaaagcggtg tatatgtcac ggtatgttta gcgctgttta ttacattcgc 712861 caccatccat gccaatattg ccggtttttc aagaatggtg tacgcattgg cgagagaggg 712921 gcacataccc gtattttttg gaaaactcag tgcgacaaaa cgtacgccta ttcgcgtttt 712981 gacagcgatg gccgcagtgt ttggcttagt gcttgcagcg catggtctgt ttcaaatcga 713041 tttgacgact ctgttgaaag ggccgagcgc ggcttttatc gcatcttaca tatgtacaat 713101 ggcggcagca ctgaaactgc tgggcaggag agatataggc tggtggatgg cgctcggggc 713161 atttgtggcg tgcgcggtga tttattcatt cagcggctgg gcactgcttt atccggcagt 713221 gctggcagct gcaggatatt tctatatgaa aacaaagggt gggcataaaa aaaagcttga 713281 tcacgttttg tgatcaagct tttccattta tccgttttga tgctcgttat ttccagaatc 713341 gctgtgttga aacatgtagg tcacaggaca gaagcgcaag attcccgaac ccgctttcat 713401 ggcccccata aagatgtaaa agagatgcat tctgcaccaa ggttttttcg taaactttgc 713461 actggcggct gacataatcg tcaatccgca ggcgattctg aacacggcat tgatgagact 713521 gatgtttggc ttcaaggaaa tccgctcctt ttacttaaaa aagtttttta atcgaacctt 713581 caaaaatttg taacgttttt atcgtgcgtg atgaggaagg atgtgatacc atgagtctaa 713641 tacatgtaaa ggagagtatg tgaatgtccg aacgcacctt taactggaaa aacaaagaca 713701 tcagggcaca ggttgatgtt gtagactcaa agctgcttcc aacgctcctt ttacggaatg 713761 ctctcgtctt aaatccatat gtaaaacaat ggctgaaaaa aaacatttgg atttatcagg 713821 accgcattgt ttatgtgggt catgaacttc cgaatagagc cgaagaaatt catacgattg 713881 attgtgaagg aaaatacatt gtgccaggtt atattgaacc gcacgcacat ccttttcaaa 713941 tatataatcc ccaaacactg gcggaatatg tgtctcaata cggaacaacg acattcgtga 714001 atgataactt atttttgctt ttgcaaagcg gaaaaaagaa agcgcttacg attttgaatg 714061 aactcaaaaa gcagcctgtc cagtattttt ggtggtcacg ctatgacctc cagaccgagg 714121 ttctgaacga ggaccacgtc cttccatttg acgtcagaaa acagtggatt gaacatccgg 714181 atgtgattca aggcggagaa atgaccggat ggcctcgcct ggtagatggt gatgatttaa 714241 tgctccactg tatgcaagct acaaagaaac agagaaaacg tattgaaggg cattttcccg 714301 gcgcttctga taaaacgctt acaaaaatga agctgttcgg tgcggattgt gatcatgaag 714361 cgatgacagg tgatgaagtg atgagaaggc tggaactggg ctattatgtt tcccttcgga 714421 actcttccat tcgccccgat gtaagaaaaa tcttgcaaga gctgcatgag aagggcttcc 714481 gctattatga ccacttcttt tacacgacag atggcgcaac cccgaatttc tataaaggcg 714541 gcatgacaaa cgagctgatt cgcattgcgt tagaagaagg cgtacctgca atcgacgcct 714601 acaatatggc atcatttaat atcgcaaagt attaccaaat ggatgattat ttaggagttg 714661 tcggaccggg cagactggca tcgctaaaca tactggaaga tccgttaaat ccgaatccag 714721 tgactgttct gtcaaaaggg accattctgc gtgaaaacgg ctgtgatttg aaggcgttta 714781 caaagacgga ctggcacaaa ggcggtcttg tcccgcttga gctttcatat gatatgacga 714841 tggatgactt gcagttttct atgccgatgg gcgtgaaaat gcggaatgcg gttattatgg 714901 agccatatat gattgagatc gacaattcga tggaacagct ctcgtttgac catgatgaaa 714961 gttatttgac gatgctcgac agacacggga aatggcgcgt caatacgatg ataaaagggt 715021 ttgcctcaag cgtgcaggga tttgtaagct cctttacgac gacgggcgac attgtcgcga 715081 ttggaaaaaa taaagcggat atgctgctcg ctttcgcccg catgaaagaa atcggaggag 715141 gaattgtttt agcggagaac ggaaacattc tgcatgaaat cccgcttgcg ctgtgcggct 715201 gcgcctcttc ggaagcgtat gaagacgtgc ttgagaagga acaaaagctg agagatcttt 715261 tgactgaaag aggctatgag ttttgcgatc ctatctatac gctgctcttt ttgcaaagta 715321 cgcaccttcc gtatatacgc attacgccaa gaggaatatt cgacgtcatg aaaaaaactg 715381 tactctttcc atcgataatg cgttaaaata taaaagagca gggagccgac atatgaaaaa 715441 atggatgaca gtttgcgcgc tgtgtttcgt gttttttctg ctggtatcct gccagcagaa 715501 ggatgctgtc ccggatactg caaagaagct gaaagctcct ttaacggggc taaagactga 715561 acagaaagtg actgaacgcc gccctgttgc tgttgtggtg aacaatcacc cgaaggcgag 715621 gccgcagtcg ggtctgtcta aagccgacat tgtcatagaa gcgctagccg aagggcaaat 715681 cacaagattt ctggccattt tccaaagcca gatgcctgaa actgtcggac ctgtgcggag 715741 cgcgcgggaa tatttcgtca ctctcagcaa tggctttgac agcatatttg tccatcacgg 715801 ctggagtccc ggcgccaaaa agcagctgga atccggagct gccgattata tgaacggatt 715861 ggattttgac ggaagcttat tttggagagc tgatttcagc aaaccgcccc acaattccta 715921 tacgtcttat gattacataa aaaaggcggc agaacaaaag ggttataagc tgaagcagga 715981 aacaaatccg ctgctgtttc aaacatcaga tgcaaaacct gcaaatgaat cttacaatgt 716041 tcgggtagat tatggaacaa ataacgttac aaatcttgtc gaatacaact atgataaaaa 716101 agctgaattt tatacaagaa gctctgatgg tgtcataacg acagaccggg aaaccggaaa 716161 gccggttgca atgcaaaata ttttcattgt tgaagccagc catcatatta ttgatcaaga 716221 tggaaggcgg gacatcgact tggaatcagg aggaaaaggt ctgttgtttc agcacggaaa 716281 cgtcattgaa acagactgga aacaagtgaa tggcagaatt gtgccggtaa aagacggcaa 716341 gtggcttccg tttgtgccag gaaagacttg gatcaatatc gtacctgatc ttgatgcggc 716401 ttccattagt aaaggagaag gtgtgtaacg atgcaaatcg ataaattacg cggcaaagag 716461 ctggaccagt tatttaactc gatcttatcg ctgaaagacc tggaggaatg ttaccgattc 716521 ttcgatgatc tatgcacaat taacgaaatt caatcgctgg ctcagcgcct tgaagtggcg 716581 cgcatgcttc gcgaaggaaa cacgtatcat aagattgaaa cagaaacagg cgcttccacg 716641 gctacgattt cccgtgtgaa acgctgctta aattacggaa atgacgctta tgaaatggcg 716701 cttgaccgtg tgaaggagac ggaaacagag tcttcttcca aataaaaaac cgccctgccg 716761 tctggcaagg gcggtttctt tatgaaacaa attgatggat caggttgtcg atattgatga 716821 tactgccatc ctctttccga tagacaacat gctccttgga aaaatgaatc ggcgaattaa 716881 tccctgctgc ggctgcaagg ttaaatagtc cctcgcgcaa tgaaataacg tagttgcaga 716941 cacgatgctg tttttcctca acgctcagtg ctttttgcaa tttcggatct gtcgtcgcca 717001 cacctgccgg acaggtgttg gtgtggcaga cgagagcgcg gatgcagcca acggaaaaca 717061 tcatgccgcg tgcgatgtta acaaagtcag cgccgagggc taaggcgacc gcgattttat 717121 caggagtcag gagctttccg gaagcaaaga ttttcagctg gctgcgcaag ccgtactgtt 717181 taagaagcgt gtccacaata ggcagcgctg tcataatcgg aaggccgact gtatccgcga 717241 gctcgtaaaa ggaagctccg gtaccgcctt cacttccgtc gatcgtgata aaatccggat 717301 gctttccgct tttctgcata tgagagaaaa gctcatgcaa ttcttcagga tgccctgcga 717361 ccagtttgat gccgactggc ttttgtccga catctctaag tttttcaata aagtcgagca 717421 tttcaggagg gtttgagaat tcataaaagc ggttcgggct gtcaatcgac tttccaggtt 717481 cgacattccg aatgtctgcc acttcctctg atactttggc gccgtccaca tggccgccgc 717541 gggttttcgc tccttgtgcc agctttagct caaacgcttt aatctggtca atcctgcttt 717601 ttcttttaaa ttcctcccac gaaaattccc cgtttctttt gcgcacgccg aataggcccg 717661 gtccgatttg gcaaatgata tcggcgccgc cctttaagtg atattcagac aatccccctt 717721 cacctgtatt catccaggtg ccgcctgcca gatggagccc ttttgagagc gccgtaacag 717781 cccgttctcc aagagaaccg tagctcatgg cagactggcc gactaagccc ttcacataaa 717841 atggcttctc gcatgtatgc tcgccaatca cctgtacatc atcaggatgg agaaaatacg 717901 ggtctgcctt gatatgttcg gcatgctcct tgcgtttgaa cagattgtca gcatccattt 717961 tatagatttg ggtttcaatt tttggcgttt gatttacatg catttcttcc ctttgttttg 718021 gaaacatagc gttacggata taatagccag gtttatcaaa atctcttaca gatccaaagc 718081 ccatcattct gcttttgtat ttgccggaga tgacggtttg ctcatattcc tttcgtgaaa 718141 atggctgctc ttcattgtca ttgctgtata aatactgtct gagctccggc ccgatttttt 718201 caaggatata ccgaaacctt ccgatgacgg gatagttgcg aagaattgag tgctcctgct 718261 gtttttcatc ctttatgtag atccaggcaa acaagacgat cgggatagcg atgatcccaa 718321 tgataaatgc gatgagtgct attatgatgg tttccatctc tcagcctccc tttttatgta 718381 accatttcca cagtagaaca ctttccaaac aatagcagaa ggaatctggt gaaaaatgtg 718441 tgctcctgcc gatacaggac tcaccatgca ggtactgcca tatgctctct ttttttatga 718501 aaaaagaatc aaaacacctt tttcagtgaa taacgagatt aacggctttt tccgtttttc 718561 cgcgctatgt gaatttgtta taatgtttaa atggtaacaa acgaatggag gaacgtatga 718621 cgtgtacgat gtaacggagt ggaagcatgt ctttaaactc gatccaaata aagatttgcc 718681 tgacgaacag ctggagattc tttgcgaatc aggaacggat gcggtcatta tcggaggaag 718741 cgatggtgtg acagaggata atgtcctgcg gatgatgtct aaggtaagac ggtttttggt 718801 gccgtgtgtc ctagaggtat cagcgattga agcgattgtt cccggctttg acttatattt 718861 tattccgagt gtattaaaca gcaaaaacgc ggattggatt gtcggaatgc accagaaagc 718921 catgaaggaa tacggagaac tgatgtctat ggaagaaatc gtggcggagg gctactgcat 718981 cgcaaatcca gattgcaaag ccgcggcact gactgaagcg gacgccgatc tgaatatgga 719041 tgatattgtc gcctatgcgc gtgtgtcgga gctgctgcaa ctgccgattt tttatttaga 719101 atacagcggc gtgcttggag acatagaagc tgtcaagaaa acgaaggctg tattggaaac 719161 gtccaccttg ttttacggcg gcggcatcaa ggatgcggaa acggccaagc agtacgcaga 719221 gcatgcggac gtgatcgttg taggcaatgc ggtgtatgaa gattttgaca gggctttgaa 719281 aacagtagcg gctgtgaaag gcgagtagta aattgtacgg atttggttta tgatagaacg 719341 tatgttttgt ataggcgggt gaacaaattt tgaattatat tagcaatcaa ttactaagcg 719401 gtttaaaccc cgttcagcag gaagcagtca aaacaacgga cgggcctctt ttgctgatgg 719461 cgggagcggg tagcggaaag acgcgtgtcc tgacccatag aattgcttat ttaatggcag 719521 aaaagcatgt ggcgccgtgg aacattctgg cgatcacatt tacaaataaa gcggcacgcg 719581 aaatgaaaga acgtgtggaa agcatcctcg gacccggcgc ggacgatatc tggatctcca 719641 cattccacag catgtgcgtg cggatcttgc gcagagatat cgaccggatt gggatcaacc 719701 gaaatttctc catccttgat acggctgacc agctttcagt gatcaagggg attttgaagg 719761 agcgcaatct tgatccgaag aagtttgacc cgagaagcat cctcggcacg atcagcagtg 719821 caaaaaacga attgaccgaa ccggaggaat tctctaaagt tgctggcggc tactacgatc 719881 aggtggtcag cgatgtatat gctgattatc agaagaagct attgaaaaac cagtcgctcg 719941 atttcgacga tttaattatg acgacgatta aactgtttga cagagtgcct gaagtgcttg 720001 aattttatca gcgcaaattc cagtacatcc acgttgatga gtatcaggat acgaacaggg 720061 cacaatacat gctcgttaag cagcttgccg agcgtttcca gaacctttgc gttgtggggg 720121 attctgatca gtcaatctac agatggcgcg gcgcggatat caccaacatt ctttcatttg 720181 aaaaagatta tccgaatgca agcgtgattt tgctagaaca aaactatcgt tcaacgaaac 720241 ggattttgcg cgcggctaac gaggtcatta aaaacaactc taaccgcaaa ccgaaaaatt 720301 tgtggacgga aaatgatgaa ggcatcaaga tttcctatta tcgcggtgat aatgagttcg 720361 gtgaaggaca gtttgtggcc ggcaaaattc atcagcttca cagcacaggc aagcggaagc 720421 tgtcggatat cgccatatta taccggacaa acgcgcagtc ccgtgtgatt gaggaaacgc 720481 ttctcaaagc gggcttgaac tataacattg tcggcggcac aaagttctat gacagaaaag 720541 aaattaaaga cattcttgcg tacctgcgcc tcgtatccaa tccggatgac gatatcagtt 720601 tcacgcgcat tgtcaatgtg ccgaagcgcg gagtcggcgc gacatcactt gaaaaaatcg 720661 cttcgtatgc ggccataaac ggcttgtcct ttttccaagc gattcagcag gttgatttta 720721 tcggcgtcag tgccaaagcg gcaaacgcgc ttgacagctt tagacagatg attgaaaacc 720781 tgaccaatat gcaggattac ttatccatta cagagctgac agaagaaatt cttgataaga 720841 cggaatacag agaaatgctg aaggctgaga aatcgatcga agcccaaagc cgtttagaaa 720901 atatcgacga gttcctgtct gttacgaaaa actttgaaca gaaaagtgaa gacaagacac 720961 tcgttgcgtt cctgacagac ttggcattga tcgcagatat tgatcagctc gatcagaagg 721021 aggaagagtc aggcggcaag gatgcgatca ccctgatgac actgcacgcc gcgaaaggac 721081 tggagtttcc ggttgttttc ttgatggggc ttgaagaagg cgtcttcccg catagccgtt 721141 cactcatgga ggaagcggaa atggaagaag aacgccgcct tgcgtacgtt gggattacaa 721201 gggcggaaca ggagctttat ctgaccaatg ctaaaatgcg caccttgttt ggccggacaa 721261 atatgaaccc ggaatctcgc ttcattgctg aaataccgga tgatttattg gaaaacctaa 721321 atgagaaaaa agaaacaaga gcgacgtctg cgagaaaaat gcagccgaga cgcggccctg 721381 tttcacgccc ggtatcctac gccagcaaaa caggcggcga caccttgaac tgggcagtcg 721441 gagataaggc gggccataaa aaatggggaa caggaactgt cgtcagcgtg aaaggcgaag 721501 gagaagggac agagcttgat attgccttcc cgagccctgt cggcgtgaaa cgcctgttag 721561 cagcatttgc tcctattgaa aagcagtaat tgaagaggaa aggaagaagc agatggacaa 721621 agaaacagcg aagcagcggg cagaagaact gcgccgcacc atcaacaagt atagctatga 721681 atattacacc ttagatgaac cgagcgtccc agatgccgaa tacgacagat tgatgcagga 721741 gctgatcgcg atcgaggagg agcacccaga cctcagaacg cctgactctc ctacgcagcg 721801 cgtcggcgga gccgtgcttg aagcgtttca gaaagtcacc cacggcacac cgatgctcag 721861 tctgggcaac gcctttaatg ctgatgatct tcgtgatttc gaccgccgtg tgcgccagtc 721921 cgtcggcgac gatgtggcgt ataatgtgga gctgaaaata gacggtcttg ctgtttctct 721981 ccgttatgaa gacggctatt ttgtcagagg ggccacaaga ggtgacggga cgacgggaga 722041 ggatatcacg gagaatctga agacgatccg caatatcccc cttaaaatga accgtgagct 722101 gtcgatcgaa gtgcgcggcg aggcgtatat gccgaagcgt tcgtttgaag cactcaatga 722161 ggaacggatt aaaaatgagg aagaaccgtt cgccaatccg cgaaatgccg cggcgggatc 722221 tctcagacag ctcgatccga aaattgcagc gaaacgaaac ctcgatatct tcgtctacag 722281 tatagcggag cttgacgaga tgggtgtaga gacgcaaagc caagggcttg attttctcga 722341 cgaactcgga tttaaaacga atcaggaacg aaaaaaatgc ggcagcatag aagaagtcat 722401 tacgctgatc gatgagcttc aggcgaagcg cgcggacctg ccgtacgaaa tagacggcat 722461 tgtcattaaa gtcgattctc tcgatcaaca ggaggagctc ggttttacgg cgaaaagccc 722521 gcgctgggcc atcgcgtata agtttcctgc tgaagaggtc gtgacgaagc ttctcgatat 722581 cgaattaaat gtcggcagaa cgggtgtgat tacgccgact gcgattcttg agccggtaaa 722641 agttgccggc acaacggtct caagagcatc ccttcataac gaagatttaa ttaaagagaa 722701 ggacattcgg attttggata aggttgtcgt caaaaaagcg ggcgatatca tcccggaagt 722761 tgtgaatgtc ctcgttgacc agcgcacagg agaagaaaag gaattcagca tgccgacgga 722821 atgtcctgaa tgcggcagtg aactcgtccg gatcgaagga gaagtggcgc ttcgctgcat 722881 taaccctgaa tgtccggcgc aaatccggga agggcttatc catttcgttt cccggaatgc 722941 catgaacatt gatgggctcg gcgaacgagt gatcacacag ctgtttgagg aaaaccttgt 723001 ccgcaatgtg gcagatttat ataagctgac gaaggaacga gtcatccagc tcgagcgcat 723061 gggcgaaaag tccactgaaa acctgatcag ctccatccaa aaatcaaaag aaaattcgtt 723121 agagcgcctg ctgtttgggc ttggcatccg ttttatcgga tcaaaggccg caaagacgct 723181 tgccatgcat tttgaaagct tggagaacct gaaaaaagcc tctaaagagg aacttctcgc 723241 ggtagatgaa atcggtgaaa aaatggctga tgctgtgatc acctattttc ataaagaaga 723301 aatgcttgaa ctcttgaatg aacttcagga gctgggcgta aacacgctct acaaaggccc 723361 gaaaaaagta aaagcagagg acagcgactc ttactttgct ggtaaaacaa ttgttctgac 723421 aggaaagctg gaagagctgt caagaaacga agccaaagcg caaatcgaag cgctgggcgg 723481 aaagctgact ggaagcgtca gcaaaaacac agacttagtc atcgccggag aagcggcggg 723541 aagcaagctg acaaaagcac aagagctgaa cattgaagtg tggaatgaag aacagttaat 723601 gggagagcta aagaaataag aggagtgttt tctattgaaa aagacgttgg cattggcggc 723661 aacggcggca gtattaatgc tgtctgcctg ctcgtcaggt ttcggggggg agaaggagga 723721 agagattacg caaaagacgg cgaaatcgtc agaaaaagcg attgtcccga aatataatat 723781 ctctgactcc tattacaaaa tggtgctgcc gtttaaggca ggcaaagcgc gcggcttaac 723841 aacggaacag ctgaatacaa ggctggacat tgacgaattt gaaacagggc tgatgcgcct 723901 tgcccaagat tctttctcaa ctgacgatta tctgttccaa gaaggacaat atttagatga 723961 ggatacagta ttaagctggc tggcacggaa aaaaacgggc tctgatttga aaaaagccga 724021 aaaagaagat aagaacttca aaaatgaagg cttgaacccg gcgctcccga gttctggttc 724081 aacagaagaa aagaacgaaa gcagcccaat ttatttagca tccatgcttg agcacgatta 724141 tttagtcaga aaagacaaga attctatcca gcttggcggc gtcatgatcg gactggcgtt 724201 aaactcagtg tattactatc gtgaaaaaac tggcgacccg caaaaagaag tggagattaa 724261 agacagcacg cttcgccagc agggagaaaa aattgcacag gaggttatta accgcctccg 724321 caaaaaagat aacttgaaga atgtgccgat taccgtggcg ctctacaagc aggcgtcaaa 724381 aacatcgatt gtgccgggga acttcatcgc caaaacagag gtcaaagcag gctctactga 724441 tatctcaaat tgggatgaca tcaatgaaaa atatgtattc tatccggcgg atacaaccac 724501 agcagaaaag tacccggatg acaccgaggt ctttaagcgg ttcaaaaact caattgaaga 724561 atatttcccg aactatacag gcgttgtcgg tacagcgctg tatgaaaatg atgaaatgaa 724621 gaaaatgaag attgacatac caatgcaatt ctacggaaaa agtgaagttg tcgcgtttac 724681 ccagttctta acgggtgaag tgatggacta ctactctaag agctcagttg atgtcgaagt 724741 caatatcacg tcctcagacg gacaggaagc ggtcattatc cgcaatgccg gagataaaga 724801 gccgactgtt cacatttatg actgatagaa aacccttgtg ccatattggc acaagggttt 724861 ttatgttaca attaacagga aaagggaaaa tattttcact tctgccgaaa cacaaatcaa 724921 ggggaggtat gttgatgctg gaaatcgtgt gaaaacaatc attatcaaat ctatagcaat 724981 gaaaggatgt tagacgtgca taaagatatc aaaaaaatat ttcatgaaga gcaggttttg 725041 gcagaagctg cagcgagata cggtttctca aaagatcagg tgcgttttct ggctgatgcg 725101 gaaaactatg tatatgaatg tatgaaagac aatcaacctt atattttaaa gattacccat 725161 acgattcgga gatcttctga ttatatgatg ggagagatgg aatggctccg tcaccttgca 725221 atagggggaa tttcagtagc caaaccgctc ccgtcgctga acggaaaaga cgtagaagca 725281 gtgccggacg gaaacggcgg gtcattttta ttgagagtgt atgagaaagc gccggggcaa 725341 aaagtggatg aatcggactg gaatgaaacg ctattttatg agcttggcag atacacaggc 725401 agcatgcaca gcctgacaaa aagctacaaa ttgagcaatc ccgctttcaa aagacaggaa 725461 tgggatgaag aggagcaatt aaagctgaga aaatatgtgc ctgaagatca gataaaggtg 725521 tttcagcaag ccgattcttt gatgaatgaa ctgcggaggc tcccgaaaag ccaggacaac 725581 tacggcttgg tgcatgcgga tctgcaccat ggcaatttta actgggatca tggcaaaatc 725641 acggcatttg attttgatga tatcggctac aactggtttg ttaacgatat tagcattctt 725701 ctctacaatg tcctgtggta tcctgttgtg ccatatgatg ataaagctgc gtttacagaa 725761 gaatttatga cgcattttat gaaagggtac tgggaggaaa atgagcttga ccctgcatgg 725821 ctgatgataa tacctgattt cctccgcctt cgccatatgc tgatttacgg attgctgcat 725881 cagatgtttg accttaacac aataggagaa gaggaaaaag aaatgctggc cggtttcaga 725941 agagatatag agaatggcac gccgattaca gcatttgatt tttcagcact ggtgtagata 726001 gaaaaagcca atgggattcc agtcccattg gcttttataa tgtatcacac ttcacgccga 726061 ctacgccttc aatggcttta atgtcatagt agacatcggt cgtgtatctg tttttatgga 726121 cgcggacctt cacttccata attggaaaat ccttttcgcc taggtcgtcg atccgaacgg 726181 agtgtgcttt gatatctctt cttttcattt cttttaaaat ctctgtcatt ttgtctttat 726241 cagaaagtga cattctgatg cggatgtctt tttcctgcag gcggtcgggg ccgatttttc 726301 tgaccaccca tgggagaaat tccacactga tcaggatgaa cagaagactg gcaaacgctt 726361 ctttataaaa accggctccc gtagcaagcc cgagccccgc tgccccccag atcatggccg 726421 atgtcgtcag gccggaaatg acatcattgc tttttcgcag gatgacaccg gcgccgataa 726481 acccgacgcc ggagatgatt tgtgccggca gacgaagcgg atccatcatg atgcggtagt 726541 atttagggaa atgatatgcc gcattaatac tgacgatcgt cagcatgcat gagctgactg 726601 cgatgacaat acaggttttt aatccgagcg gcttattttt taattcgcgt tcaagcccga 726661 tgaccatgcc aatcaatgtg gcaatgccca atttcaataa aatatcagga tcaatatacc 726721 agctcaacag caaacttccc ccttctctat ggtgttttta aataaatatg attttctcac 726781 agtatttata gcaaaacaag agcacaaaag ccaccaagct gcgcttgatg gcttattgct 726841 tactttttgc gttttaacag cttttccatg acaccgaata atcggtaaga ggcttttgca 726901 ggacgttttg tgatcatgct gacaatgatg ccggcaatca tactgagaat aaacccaggg 726961 atgatttcgt acacaccggt tgattttgcc aggccggttg taatccagat caacacggtc 727021 gcagccccga caatcatggc agcaagcgcg ccccattcgt tcattcgttt ccaatacaga 727081 ctgagcagaa tcgcaggccc gaaagctgaa ccgaagccgg cccaagcgta tccgaccaaa 727141 tcaagaatgg tgctgttcgg gttcaatgac aagagtaccg cgataacggc aatgactaag 727201 acggacaatc gcccgatcat gaccaattct ttatcagaag cttttcgtct gaaaaatgac 727261 cggtataaat cctctgttac agcacttgct gtgaccaaga gctgtgagga aatcgaactc 727321 atgatggcag ccaaaatagc tgacaataag aaccctgtaa ttaatgggtg gaacaagatt 727381 ttagagaaga taatgaaaat catctccgga tcttttacag caactccgaa tttatgggcg 727441 tatgcaacac cgattaaacc cgtcagcacg gaacctagaa ctgtaatgat catccagctc 727501 atgccgattc ggcgtgcagg ttttaaatct ttaatgtctt taatggccat aaatcggacg 727561 atgatatgag gctggccgta gtagcccaac ccccaggcta aataggaaat aatgctaatg 727621 acgctcgcgc ctttaaaaat atccaataaa tgtggattaa cagcgtcgat ttcatggaaa 727681 gtcggagcaa cgccgcccac atgggtaaaa gcaacgatcg gcacaagcac tagtgctgca 727741 aacatgatcg caccctgcac gaagtcagtc agactgacag caaggaaacc gccaaacagt 727801 gtgtataaca cgacaactgc ggtggtcaga aacaggccta atttgtaatc cgcaccaaaa 727861 gcagattcaa acagccgtcc gccagatacc ataccggaag aggtatacaa tgtgaaaaag 727921 atcatgatga tcaatgcaga tacgattttc agcagtgatg aagaatgctg gaatcgttta 727981 tcaaagaaat caggaattgt aatcgcatca tctgccgctt ctgtataagc acgcagcctt 728041 ggagccagca gcaagtaatt tgagtacgcc ccgattgtaa gacctaaagc aagccataag 728101 gtggacagcc ctgtcgcaaa catcgcgccg ggaacaccca tcagcatcca tccgctcata 728161 tcggccgcgc cggcagacaa agcagtaacg aatggtccga ggcctcttcc tccaagcatg 728221 taatcattga tgtcagtggt tttcttgaat gcataccagc cgattaacag catggcaata 728281 aagtaaattc ctaaagatat aataatttca atactcacgt tttaccctct cttcatttct 728341 aataatgttg catcacctct caaattgatg gtgccagtta agcagcctgg cgtaagtgca 728401 aaacaaaaga aattcttttg cgggtgcact tggtaactta acctaacaaa gtattcccgg 728461 ccattcaagc gatgaaacat tgatcataag ctggaaatac cgttgcaaac ctagaaggga 728521 ataaagaata aaacgctttc aaaaaataat taaagtaaaa atattcagaa aaatatttcg 728581 tttctccttc tcctcatttt agtataaaat atatagggta ttgtttcgaa aacacaggcc 728641 tgtctcaagg cgttttgttg ctttaaaggg cttgtttttg atatgatcag tattatatga 728701 cttaacggag aaatatgtgg aggtggatca tatgtcacga atttcaatag aagaagtaaa 728761 gcacgttgcg caccttgcaa gacttgcgat tactgaagaa gaagcaaaaa tgttcactga 728821 acagctcgac agtatcattt catttgccga ggagcttaat gaggttaaca cagacaatgt 728881 ggagcctaca actcacgtgc tgaaaatgaa aaatgtcatg agagaagatg aagcgggtaa 728941 aggtcttccg gttgaggatg tcatgaaaaa tgcgcctgac cataaagacg gctatattcg 729001 tgtgccatca attctggact aaaggaggga cacaagaatg tcattatttg atcataaaat 729061 cacagaatta aaacagctca tacataaaaa agagattaag atttctgatc tggttgatga 729121 atcttataaa cgcatccaag cggttgatga taaggtacaa gcctttttgg cattagatga 729181 agaaagagcg cgcgcatacg cgaaggagct tgatgaggcg gttgacggcc gttctgagca 729241 cggtcttctt ttcggtatgc cgatcggcgt aaaagataat atcgtaacaa aagggctgcg 729301 cacaacatgc tccagcaaaa ttctcgaaaa ctttgatccg atttacgatg ctactgtcgt 729361 tcagcgcctt caagacgctg aagcggtcac aatcggaaaa ctgaacatgg acgaattcgc 729421 catggggtca tctacagaaa actcagctta caagctgacg aaaaaccctt ggaacctgga 729481 tacagttccc ggcggttcaa gcggcggatc tgcagctgcg gttgctgcgg gagaagttcc 729541 gttttctctt ggatctgaca caggcggctc catccgtcag ccggcatctt tctgcggcgt 729601 tgtcggatta aaacctacat acggacgtgt atctcgttac ggcctggtcg catttgcgtc 729661 ttcattggac caaatcggac cgattacacg tacggttgag gataacgcgt ttttacttca 729721 agcgatttcc ggcgtagaca aaatggactc tacgagtgca aatgtggacg tgcctgattt 729781 tctttcttca ttaactggcg acatcaaagg actgaaaatc gccgttccga aagaatacct 729841 tggtgaaggt gtcggcaaag aagcgagaga atctgtcttg gcagcgctga aagtccttga 729901 aggtctcggc gctacatggg aagaagtgtc tcttccgcac agtaaatacg cgcttgcgac 729961 atattacctg ctgtcatctt ctgaagcgtc agcgaacctt gcacgctttg acggcatccg 730021 ctacggctac cgcacagaca acgcggataa cctgatcgac ctttacaagc aaacgcgcgc 730081 tgaaggtttc ggaaatgaag tcaaacgccg catcatgctc ggaacgtttg ctttaagctc 730141 aggctactac gatgcgtact acaaaaaagc gcaaaaagtg cgtacgttga ttaagaagga 730201 tttcgaggac gtatttgaaa aatatgatgt tattgttgga ccgactacac cgacacctgc 730261 gtttaaaatc ggtgaaaaca cgaaggatcc gctcacaatg tacgcaaacg atatcttaac 730321 gattccggtc aaccttgccg gcgtaccggg aatcagtgtg ccatgcggat tagcagacgg 730381 acttccgctc ggcctgcaaa tcatcggaaa acactttgat gaaagcactg tataccgcgt 730441 tgctcatgca tttgaacaag caacagacca tcataaagca aaacctgaac tgtaaggggt 730501 gaaaagaatt gaactttgaa acggtaatcg gacttgaagt ccacgttgag ttaaaaacaa 730561 aatcaaaaat tttctcaagc tctccaacgc cattcggcgc ggaggcgaat acgcagacaa 730621 gcgttattga cctcggatat ccgggcgtcc tgcctgttct gaacaaagaa gccgttgaat 730681 tcgcaatgaa agccgctatg gcgctcaact gtgagatcgc aacggatacg aagtttgacc 730741 gcaaaaacta tttctatcct gacaacccga aagcgtatca gatttctcaa tttgataagc 730801 caatcggcga aaacggctgg atcgaaattg aagtcggcgg caaaacaaaa cgcatcggca 730861 tcacgcgcct tcatcttgaa gaggatgccg gaaaactgac gcatacgggc gacggctatt 730921 ctcttgttga cttcaaccgt caaggaacgc cgcttgttga gatcgtatca gagccggaca 730981 tccgcacgcc ggaagaagcg tacgcatatc ttgaaaagct gaaatccatc atccaatata 731041 caggcgtttc tgactgtaaa atggaagaag gctcacttcg ctgtgacgcc aatatctctc 731101 ttcgtccgat cggccaagag gaattcggca caaaaacaga attgaaaaac ttgaactcct 731161 ttgcgtttgt tcaaaaaggc cttgagcatg aagaaaaacg ccaggagcag gttcttcttt 731221 ccggcggcgt catccagcaa gaaactcgcc gttatgatga agcaacgaag aaaaccattc 731281 ttatgcgtgt caaagaggga tctgacgact accgttactt cccagagcca gatctagtcg 731341 agctctacat tgatgatgaa tggaaggaac gcgtaaaagc aagcattcct gagcttccgg 731401 atgagcgccg caagcgttat atcgaagagc ttggcttgcc tgcatatgac gcaatggttc 731461 tgacgctgac aaaagaaatg gctgatttct tcgaagaaac cgttcaaaaa ggcgctgaag 731521 ctaaacaagc gtctaactgg ctgatgggtg aagtgtcagc ttacctaaac gcagaacaaa 731581 aagagcttgc cgatgttgcc ctgacacctg aaggccttgc cggcatgatc aaattgattg 731641 aaaaaggaac catttcttct aagatcgcga agaaagtgtt taaagaattg attgaaaaag 731701 gcggcgacgc tgagaagatt gtgaaagaga aaggccttgt tcagatttct gacgaaggcg 731761 tgcttctgaa gcttgtcact gaggcgcttg acaacaatcc tcaatcaatc gaagacttta 731821 aaaacggaaa agaccgcgcg atcggcttcc tagtcggaca gattatgaaa gcgtccaaag 731881 gacaagccaa cccgccgatg gtcaacaaaa ttctgcttga agaaattaaa aaacgctaat 731941 aaaaaagcag cccttagagg ctgctttttt tatggtcaaa ttgagataaa gacaagatga 732001 gggcccgaag cctttcaact tctttgtcgt tggttccggc caaattggac agcatgcctt 732061 taataatcgg cttgcgcggt ttatcctgag tcaattcttc ctcgataaca tcaagtgaca 732121 cggtgatatc ctcgggcagc gtgctgtttt ctttcacttt ctgaatgtcc tcaagcagct 732181 ggtcttttcc cgcaggcatc gggttaaaaa tgtcttttga tacaatcgga ttgagtgcag 732241 aacggctcag cccctgtaca agatcatcca gtctctcaat aataaaggct gagatttctt 732301 ctgcatcgat attaagctca ccgttaaata ccatcacgtt catataggaa tgcacaatgc 732361 ctcttgccat gatggacaga tctgcgacat accgctcgat tccttcgcca taggatacca 732421 gcaaggcgtt ccggtacagc ttatccgtct ccatggttac tttgtaaaag tattgcttga 732481 tttcttgatt ttccggaatg atattttcgg taagcaaaag aacgataaaa tctttatgat 732541 cgcgaaaatc ctcaaattga gcgccaattt gcttttttaa cacttcctta ggcggctttc 732601 cggcgagatc ttcttctata tttttcattt tgttcataga cataccgata taatattcac 732661 aggcagataa cagcagcgct tctttcgatt tgaagtgcaa ataaaaagcg cccttcgaaa 732721 tgccgcattc actggcgatt tcttggatcg tcgtagctgc gaatcctttt ttcgcaaata 732781 aacgaatgct ggtttttatg attctctctt ttttttcatt catgacgtgc ttccccttaa 732841 tccttgaaaa atttagtaaa attttctggt atatgagttg acgttgttgc gttataacgt 732901 ttagtattat atagaatgac cagtcagtca ataaaaaatg taatggagga tatgatgaac 732961 cacgttatta atttcgttct gaaaaacaaa ttcgccgtat ggctgatgac gattattgta 733021 acggcagccg gcttgtatgc gggtatgaat atgaagcaag agtctattcc tgacgtgaac 733081 atgccttact tgacgatcag cacgacatat ccgggtgcaa caccaagcca agtggctgat 733141 gaagtgacca aaccggttga acaagccgta cagaacttgg acggtgtcag cgttgtgacg 733201 tcgacgtcct atgaaaacgc atcgtcggtc atgattgaat atgattatga gaaagatatg 733261 gacaaagcga aaacagaagc agctgaagcg ttagaaaacg tcaacctgcc tgatgacgcg 733321 aaggatccgg agatttcacg ctacagcttg aactcattcc cgattctgac gctgagcgtg 733381 tccagtgata aagataatct gcaagagctg acgaaacaag tggaggacag cctcgtttct 733441 aagcttgaag gcatagaagg cgttgcgtcc gtccaagtat caggccagca ggtggaagag 733501 gttgaattct ctttcaaaga agacaaactg aaggaatacg gccttgatga agatacagtc 733561 aagcaagtga ttcaaggttc agatgtgaca actccgcttg gattgtacac attcggaaat 733621 gaagaaaaat ctgtcgtcgt cagcggcgat attgaaacaa ttaaagattt gaagaatatg 733681 agaatcccga cggcatctgc ttcaagtgca ggcagcagcg cagcatctca agcaggtgcg 733741 cagagtgctc aagcagccca aagcgcgcaa gcggcagcac aggtgcagca aagcgcaagc 733801 acagcagtgc cgacggtcaa gctttctgac attgctacaa ttaaagatgt gaaaaaagct 733861 gaatccgttt cacgcacaaa tggcaaagac agcatcggca tcaacatcgt caaagcaaac 733921 gatgcgaata cggtagaggt tgccgacgat gtcaaagctg agctgaaaaa gttcaaagaa 733981 gaccataaag gcttcaatta cagcgcaact ctcgacatgg cggagccgat cacacagtca 734041 gttgacacga tgttaagcaa agccatcttc ggtgctattt ttgcgattgt gattattctc 734101 ttattcttaa gagatatcaa atcaacatta atttctgttg tttcaattcc attatcattg 734161 ctgatcgcac tccttgtgct gcagcagctt gatatcacat tgaatattat gacgctcggc 734221 gcaatgaccg ttgccatcgg acgtgtagtc gatgactcca tcgttgtgat cgagaacatt 734281 taccgccgca tgagactcaa agatgagccg ctccgcggaa aagccttggt tcgtgaagcg 734341 acgaaggaaa tgtttaaacc gatcatgtca tcaacgattg tgacaatcgc ggtattcctg 734401 ccgctcgcac ttgtaggcgg acaaatcggt gaattgttta ttccatttgc cttaacgatt 734461 gtttttgcgc ttgccgcatc cctagtgatt tcaatcacgc ttgtgccgat gctcgcacac 734521 agcctgttca aaaaatcatt aaccggtgcg ccgattaaag cgaaagaaca caaacctggc 734581 agacttgcaa acatctataa aaaagtattg aactgggcgc tgagccacaa atggatcacg 734641 tctatcatcg cggttctgat gctccttgga agcttgttcc tcgtaccgtt aatcggtgcc 734701 agctacctgc cgtccgagga agaaaaaacg atgcagctca catacagccc agaaccgggt 734761 gaaacgaaaa aagaagccga aaatgaagct gaaaaagcgg aaaaaatcct gcttgaccgc 734821 aagcatgtcg atacggttca gtattcatta ggctctggca gcccgcttgc cggaggagat 734881 tctaacggtg cgttattcta tatcaaatat gaaagcgaca cacctgactt tgataaagaa 734941 aaagataacg ttctgaagga aatccaaaag caatctgacc gcggagaatg gaagtcacag 735001 gacttcagct cttcaggcaa taataacgaa ttaacatact atgtgtatgg cgattctgaa 735061 aacgatatta aagacacggt caaagacatt gaaaaaatca tgaaagatga aaaggatctg 735121 aaaaacgtaa attcaggcct ttccagcaca tatgatgagt acacatttgt cgctgaccaa 735181 gaaaaactaa gcaagctcgg tttaaccgcg tctcaaattt ctcaggcctt aatgtcacaa 735241 acatcgcaag aaccgctcac cactgtgaaa aaagacggca aagagcttga tgtgaacatt 735301 aagacagaaa aagacgagta taagagtgtg aaagatttag agaataaaaa gatcacttcc 735361 gcgactggcc aggaagtcaa aatcggcgat gtggcaaaag tgaaagaagg atcaacatca 735421 gataccgtgt caaaacgtga cggaaaagtc tatgcagatg tcacaggtga ggttacctct 735481 gacaacgtca cagccgtatc agctgctatc cagaagaaaa tcgataagct tgaccaccct 735541 gataacgtat cgattgacac aggcggcgta tcagcggata tcgctgattc cttcacgaag 735601 ctcggtttag cgatgctggc agcaatagcg atcgtttacc ttgtgctcgt gattaccttc 735661 ggcggagcac tagcgccatt tgcgattctg ttctcattgc cgttcacagt catcggtgcc 735721 ctggtcggac tttacgtatc aggtgaaacg atcagtctga acgccatgat cggtatgctc 735781 atgctgatcg gtatcgttgt cacgaatgcc attgtcttaa ttgaccgcgt gattcataag 735841 gaagcggaag gcctgtctac gagagaagcg ctcctggaag ccggctctac acgactccgt 735901 ccgatcctga tgacagccat tgcgacaatc ggcgccttga ttccattagc cctcggcttc 735961 gaaggcggaa gccaggtcat ttcaaaagga ctcggcgtaa cggttatcgg cggtttaatc 736021 agttcaacgc ttctgacgct cctgatcgtg ccaatcgtat atgaagtatt ggcgaagttc 736081 cgcaagaaaa aaccgggaac ggaagaagag taaaaaacaa aaagcctcag ctctgctgag 736141 gctttcagct tgttgaaaaa ccctcgcatt cgttgtcagg tctgcgcgtc ggtgctcacg 736201 aattctacat tcgctccgct ccaatgctcc cccttcctag actacaaggg ttttcaatca 736261 agctgaaaga atgttaagga tgacaaaagc tcaaaacaag aatcagtttt gagcttttgt 736321 gcgttttcac ctgtaagatt atgtacattt tgttgcgatt tttttaactc atagtataat 736381 taaaggttgt tagtgtaaaa atggatcgga tactcttaag taggatgatg agataatgaa 736441 acgtgcacgc ataatataca atccgacttc aggacgggag atctttaaaa agcatcttgc 736501 ccaggtcctg caaaaatttg aacaagccgg ctatgaaacc tccacccatg cgacgacatg 736561 cgcaggagac gctacacacg ctgccaagga agcggcattg cgtgagtttg acctgatcat 736621 tgcggcaggc ggagacggaa cgatcaacga ggtcgtcaac gggcttgcgc ctttagacaa 736681 tcgtccgaca ctcggtgtga ttcctgtcgg cacaacgaac gacttcgcca gagcgctcgg 736741 aatcccacgc gaggatattt taaaagcggc agatacggtc attaacggcg ttgcccgccc 736801 gattgatatc ggacaggtca acggccagta ttttatcaat atcgccggcg gaggccgtct 736861 gacggagctg acgtacgacg tgccaagcaa actgaaaaca atgctcggcc agcttgctta 736921 ttatttaaaa ggaatggaaa tgctgccttc acttcgtccg acagaagtcg agattgaata 736981 tgacggcaag ctgtttcaag gtgaaatcat gctgtttttg gtcacgctga caaactccgt 737041 cggcgggttc gaaaagctcg cgccggattc cagcctgaat gacggcatgt ttgatttgat 737101 gatactaaag aaagcaaacc ttgctgaatt tatcagggtc gccacgatgg cgcttcgcgg 737161 agaacacatc aacgaccagc acattattta tacaaaagcg aaccgcgtga aagtcaatgt 737221 atcagaaaag atgcagctga acctggacgg cgagtacggc ggcatgctgc cgggcgaatt 737281 cgtgaatctg taccggcaca ttcacgtcgt catgccgaag gagaaagcgg aacagttgga 737341 tgactaaaac ttggcttggt aagccaagct cagaatgttg acaaaatcct aaaacagttt 737401 tcgttttagg attttgtcat cttttcagcg tgattgaaaa cctttgaagt ctaggaaggg 737461 cgagcatcgg agcacagcga atgttgaatt cgtgagcacc gaagcacagg cctgacaacg 737521 aatgcgaagg tttgcctaca cgctgaaact tggcttgaat aggccaagtt tttctttcgc 737581 ttaaaactag aggtgattat agatgaaaat gaaaccccca gtagaaaaaa atgaatacta 737641 cgatgtgaca tttgaggatt tgacacatga aggagcgggc gtcgcaaagg tccaaggctt 737701 cccgatcttt gtgccgaatg ccctacccga ggaaaaagcc caaatcaaag tgacacgcgt 737761 caaaaaaggg ttcgccttcg gccgcctgat tgagctgaag gaagaaagcc cgcatagaac 737821 ggacgcccca tgcccgattt acaaacaatg cggaggctgc cagcttcagc acatgaccta 737881 cgaaggccag ctcctgttta aacagaaaca agtcaaagac gtcttagaac gcatcggcaa 737941 gctggacctt tcaaaagtca ccgtgcaccc gacactcggc atggaagacc cgtggaacta 738001 cagaaacaaa gcacaggtgc cggtaggaga acgggaaggc ggactcgtcg cgggattcta 738061 tcagcaaaga agccatgaca tcatcgacat gagcgcctgc ctgatccagc aatccaaaaa 738121 cgacgaagcc gttcaagctg tcaaagacat ttgcgcaaac tacggtgtca aagcctacaa 738181 cgaagaacgc cacaaaggct ggctccgcca catcatggtc agatacggcg ttgttacggg 738241 cgaaatgatg atcgtcttca tcacaagaac aagcgacttc ccgcacaaag cgaagatcat 738301 cgaagacatc acagcgcaat tcccgcacgt caaatccatc gtgcaaaaca tcaacccaaa 738361 caaaacaaac gtcatttttg gcaacgaaac aaacgtcatc tggggcgaag aatacatcta 738421 cgacctcatc ggagacgtca aattcgccat ctccgccaga tcgttttatc aggtcaaccc 738481 agagcaaaca aaagtgctct acgacaaagc gcttgagtac gctgagcttc aaggggaaga 738541 aaccgtcatc gacgcttact gcggcatcgg aacgatttct ctcttcctgg caaagcaggc 738601 gaaaaaagtg tacggtgtag agattgtgcc ggaagcaatt gaggacgcga agcgaaacgc 738661 cgaattaaac ggcaacacaa acgcagagtt tgctgttgga gaagcggaaa ccgtgattcc 738721 aaagtggtac gaagaaggca ttacagctga tacgctggtc gtcgacccgc caagaaaagg 738781 ctgcgacgaa gccctcctgc ggacaattgt ggagatgaag ccgaagcggg tagtgtatgt 738841 gtcctgtaat cctggcacgc ttgcgagaga tttgcgggtg cttgaggatg gcgggtacgt 738901 gacgcgcgaa gtgcagcctg tggatatgtt tccgcatacg aatcatgtgg agtgctgtgt 738961 gttgataaaa ttaaaagaat aaatagtcaa aaatctatgc tgatggaact gttggttctc 739021 taaaacgata attgatttca atggttccat ttgcatgtac ttctatttca tctactaaca 739081 aatgaagcat ttcgggggta agtgtacctt ccttcatgaa tttatctaag ctctttttaa 739141 aatcaattat ttctttttca atcttttgaa attctaggtc cttagatagt tggtgaaggg 739201 tagtttcaaa atttgaaata tcttcattgg tgatatttat ggctaattgg taatcttctt 739261 tagatataac accattagca agagagataa ctaaattgga tttatctctc tttttatcgt 739321 ttaatttttc attaatttcg attatcttag attcgatttt ttctttgtac tttaacgctt 739381 tttcacttaa ttctttaaaa taattttcct tactgaattt caaatatatc ttatttaggt 739441 tggttattac tttatcagtt aaatctattt cacttacgta atgatcacta catgctttta 739501 aaccatgttt attataactt ccacaaacat aaccttttcg attcttttta aaatgcattg 739561 acctcctgca atctttgcaa accgcagtat ttgtaaagag atgtacttca gcttgaggtc 739621 tccttctttt tctagttatt aaaatctctt gtacaataag aaagtcttct aaaggtatga 739681 ttggttcgtg gcttttttca ataattattt ggttttctag gttaactgac cttcttcttt 739741 tactggtaac actcggtcta tattctctac attgttgtag tgtcccagta tagtgaggat 739801 tttcgagaat ttttcttatt gaagatccgt gccatttgtc agtagcgttc tttttgcggg 739861 caagctgcga gggactagtg accccttcgt tatacaatcc ccttgctatt gcatcaaagc 739921 cttttccagc aatatattct gaaaagattc taatatttac tattttctct gcgtttgctg 739981 aatttgagag agatatgatt gtagaacgaa ctcaagaagg taaaatgttg gccaagcaga 740041 atccggattt ccgagaagga agacccaaaa agttcacaaa gcagcaaatc aatcatgcat 740101 taacattact agaaaatcat tcgtataaac aagttgaaga tatgactggg atatcagttt 740161 ctacacttgt aagagctaaa aagaagaaag ctgctgaagc tataaatgga taaatattgt 740221 gaattaatta ttcaatatct tgagaaattt ttataaaagt aatcaaaagt ttaatggggg 740281 aaacgaaatg gcgctcattg atttagaaga taaaattgct gaaatagtga atcgagaaga 740341 tcattcagat ttcttgtatg aattactcgg tgtatatgat gttccacgag ctacaattac 740401 gcgcttgaaa aaaggaaatc aaaaccttac aaaacgggtt ggtgaagtac acttaaagaa 740461 taaggtgtgg tttaaggagg ctaagaaagg aaagctcttt gacgccctta ttgatataga 740521 acaacaagtt gaatatcttt cagctaagcc acgatattta ttagttactg actatgatgg 740581 agtattagcg aaagatacaa aaacattaga ggctcttgat gttaaatttg aagaacttcc 740641 tcagtatttc gatttcttcc ttgcttggaa aggtattgag aaagtagagt ttgaaaagga 740701 aaaccccgct gatattaaag cagccgaacg ttttgcacgg atatatgatg tacttcgtaa 740761 agaaaacaat attattgaga ctaatagagg gttagattta tttcttattc gtttactgtt 740821 ttgttttttc gcagaagata ctgacatctt caaacgaaat agttttacga atttaattaa 740881 gactttgact gaagaagatg gttcaaatct aaataaatta tttgctgatt tatttatcgt 740941 gttagataaa aatgaacgag acgatgttcc atcttattta aaagagtttc cgtatgtaaa 741001 tggccagttg tttactgaac cacatacaga gttggaattt tctgccaaat ccagaaagtt 741061 aattattgag tgcggtgaat tattaaactg ggctaaaatc aatcctgata tctttggttc 741121 aatgattcaa gctgttgctt ctgaagaaag ccgtagttat ttaggtatgc actacacaag 741181 tgtccccaat ataatgaagg ttattaaacc gcttttccta gataaactta atcagtcttt 741241 tttagatgca tacgatgatt atacaaaact tgaaaatctt ctaacacgaa tcggcaaaat 741301 taaattcttt gatcctgcat gtggttcagg gaactttttg attattacct acaaagaatt 741361 acggcgtatg gaaatcaata ttataaaacg acttcaagaa ctcttgggag agtatcttta 741421 tgtaccttca gtaactttat ctcaatttta cggaatagag attgaagatt ttgcacatga 741481 cgttgcaaaa ttatcacttt ggattgctga acatcaaatg aatgaagaat taaaaaatga 741541 agttcataat gcagtacgcc caacgttacc acttcataca gcaggggata ttcgttgtgc 741601 aaatgctatt agggttgagt ggactgaggt ttgtcccgca caaggatctg aagaagtata 741661 tgtttttggt aatccaccgt atcttggttc aaaaaaacaa aacaaagaac ataaatctga 741721 tatgttatca atttttggaa aagtcaagaa tggtaaaatg cttgattata tttctgcttg 741781 gttttacttt ggtgctaaat acgcttcaac tacaaatgca aaagttgcct ttgtatcaac 741841 aaattcagtt actcaagggg aacaggtttc tatcttatgg aatgagttat tcaagtttgg 741901 aattcaaatc aattttgcct ataaatcttt taaatgggcg aataatgcta aaaataatgc 741961 tgcggtaatt gttgtgattg taggttttgg cccgttagat accaaagtaa acaagtattt 742021 atttgttgat gaaacgaaaa agctagtttc taacattagt ccctatttaa ctgatggtga 742081 aaatattctt gtttcttcta ggacgaagcc aatttcagac ttacccaaac tgcattttgg 742141 gaacatgcct aatgatggcg gaggattact ctttaccatt acggaatata cagacgcaat 742201 caataagtat cctgaattag ttccctattt taaaaagttt ataggttcag tagagtttat 742261 taatggtggt ttacggtatt gtttatggct taatgaagca aaatatgaaa aaataaagtc 742321 taatcctcta atacaagaaa gaatctcaat ttcaaaaaat cacagggaaa aatcaacaga 742381 taaaggaacg aataaacttg cattaactcc gtggaagttt agagatactc atgaaacaac 742441 taattattcc attgttgttc catctgtgtc ttctgaaaat agattttata ttccaatggg 742501 attagcaggt gcagatacaa ttttgtcaaa tctaatttat gtaatttacg atgcagaaat 742561 ttaccttcta ggcattttga tgtcacggat gcatatgact tgggtaaaag ctgtagccgg 742621 aagattaaaa actgactata ggtactctgc aggtttatgt tataacactt tccctattcc 742681 tgaattatca acaagaagga agaatgaaat tgaagaagca attcttgaaa ttcttgatct 742741 tcgtgaagag cagggtggta cattagcaga gctttataac ccttcaacaa tgccaattga 742801 attaaaagta gcacatgaaa agttggatgg aattgtagaa agagcgtatc gtcaaaaaca 742861 atttgaatct gatgaagaac gcttagaagt attgcttaaa ttgtatcaag aaatgacaga 742921 acggtaggtg taaggtgtat ggaaaatata attgaaatta attataacca aactggtaaa 742981 agtaagaaaa caaatgaata cggtatgcgt gaaatgcagg caagagcttt tgaaaaacgt 743041 aactcacaat atctcttagt taaagcaccg ccagcttctg ggaaatctag agctttaatg 743101 tttatcggtt tggataagct cataaatcaa ggtttgagga aagtgattgt tgctgtacct 743161 gaacgctcta taggttcttc atttaaaaat acggatttaa aaagttatgg tttctttgaa 743221 aattggaaag ttgatcctag aaataattta actgttggcg gagataactc taaggttaaa 743281 tcttttgttc gttttatgga atcggacgat caggtgttaa tatgtacgca ctctactttg 743341 cgatttgcgt ttgaaaaaat tgatgataaa gcatttgata attgtttact tgcaatagat 743401 gaatttcacc atgtatcggc agatgtcaat tctcgattag gtgaattgtt aagaagtatt 743461 attcataatt catcagcaca tattgtagcg atgactgggt cgtatttccg tggagattct 743521 gtaccaattt tattaccaga agatgaggaa ttatttgaca aggtaactta ttcctattat 743581 gaacaacttg atggatatga atatctaaag ggatttggta taggatatca cttctatcaa 743641 ggccagtaca catcagctat taatgaagta ttggatacaa ataagaaaac aatcgttcat 743701 attccaaatg taaactcagg ggaatcgaca aaggataagt acgatgaagt tggtaagata 743761 cttgatatga ttggtgaagt tgaatatcaa gatgatgata ctggaattat ttatgttaag 743821 cgacattctg acggtaaaac attgaaaatt gcagatttag tagatgacca agttggaaga 743881 gaaaatgtcg ttgcgtattt gcgtaatatt gaagccctag acgatttaga tataattatt 743941 gctcttggta tggcgaaaga gggctttgac tggccgtttt gtgaacatac tttgacagtt 744001 ggttatcgtg gctcacttac agaaatagta caaataattg ggcgctgtac acgtgatagt 744061 tacaataaaa cctatgctca atttaccaac ctaatcgcaa tgcctgatgc aaaggatgaa 744121 gtagtgactt atacagtgaa tacaatgctt aaagctattt ctgcctcact tttgatggag 744181 caggtcctta cacctgactt taaatttaaa cgtagaagaa atgaaagtga aaaatcttct 744241 actacaggag aattattcgt taagggattg aaagaaccat caacagaaaa tgtcaaaaag 744301 attattgaaa atgatattaa tgatttaaaa gcaaaaatca tgcaagattc acaagtccaa 744361 aaaacattta gtggagaagt agatcccaaa gtattgaaca aagtgttgat tccgaaagtt 744421 attcaaaaag tatatccaaa tttatcagat gaggaaattg aggaagttag acagcacgtt 744481 gttctagata cagttatgaa aggtgctaag tctgaagttg taggaagtaa agaatttata 744541 agaatggcag ataagtttat aaacattgag gatttagata tcaatctgat tgattccatc 744601 aatccgttcc aaaaagcatt tgaggttcta tcgaaagaat tgaactcacc agtgctaaaa 744661 ctgattcagg aaactattga tgcaaaacgt attaattttg atgaagatga actagtattc 744721 atatggccaa aggtttagga attttatcgt tcaactggta gaagacctga ttcaaaatct 744781 gaagacccac ttgaaaggcg tatgggtgaa gctgtattat acatgcaaga gcttaggagg 744841 aaacgtgaaa atggcaagta atagatacca ttctattaat gaaatcatgg aaagtcagct 744901 gttttaccaa atcacaacac cacctaagaa aacacaaaaa gcccagtatg atcctgaagt 744961 tgaaaagttt ttggagatta ttgaattcgt caaagaaaat gggcgagaac cccaaaaagt 745021 ccctactgat ttaactgaaa gaagtttagc aagtcgatta attgggattc ggaaagatcc 745081 tgatcgtatg gaatatttga aagagtatga tgaaattgga ttacttgaag taagatcgaa 745141 ggaactaaca attcctaaaa tttcttcaat tgatgatatt ctaaaaagtg gcttatctgc 745201 attattaggt gataatttaa ataatgatat aactaggtca atttttgata caagttcact 745261 tcaaaaggtt acgacaatgc ctgaatacgt tgcaaagcgt aaaaaaataa aagattttgg 745321 aaagtttgaa gagctattca agaagtgcca caaggaaatt acagagggta aacgaaaaat 745381 tttaactttc aaaaatgaac aagacataca gtcaaatagt ttttatatat taaaaggagt 745441 tcttctttat gttgaagatg tgggagaacg taaaaaagca aagggaaaaa ccaatgctag 745501 acttcgatgt atatttgaaa atggaacgga atcagatatg ttactacgtt ccttatcagc 745561 ggagttatat aaacatggta gacgtgtgac cgacaatgaa gatacattgt tggataatgt 745621 tagagaagat gatgtttcga ctggctttat ttacgtacta aaatctttga gtacagatcc 745681 gcaaattagt tccattaaga atttatataa gatcggtttt acaactggtt cagtagaaaa 745741 tagaatcagg aatgcagaaa atcaatcaac ttatctttat gctccagtag aaattgtaac 745801 cacatatcaa gtgttcaata tgaatgctag caaatttgag acggcaatcc atcatgcgct 745861 agcaaataat aatttggatg tttctatttt gggggcaaat ggaaagatgt tagttcctaa 745921 agagtggttc gttgtcacac ttgaagattt acaagctgta atagatgaga ttgtgatgat 745981 ggttcatctt tatgactaaa ttagtatatt aggattttag tattaataat aattttatag 746041 tagactatga aaaaatttga tgccataaca ataacttgtt ccgctttgga gtttgtcaca 746101 attgtagaat tatgtgttgc gagtattaat aggaaggggt tgagcgaccg caaaaaaaat 746161 tttcggtgct gtccgcaaaa gggagtttgg gtgttttgcg ttatatttgg ttgtgtgaag 746221 gttagcggaa actcaattcg tgaagttagg attgcggtta ttacgactga gtagtttcgt 746281 catactcttt tagcagtttt tctgtcttat gcatttcttt gagcatcgga ttcatgtagt 746341 cgttagctga ttctagatat gctctcgtca gagtgtctag tttatttcta actttagaga 746401 ggtcttcttc gaattttcca tccgatgatt gaaggataaa ttcttttgcc tcttcatatc 746461 tttttaatat gtttttcacc attggagttg gattcttttg atttattgtt tttattacag 746521 tgattgttaa atttatttgt tttattaatt cttttcttac tgtcaaggtg atgctccttt 746581 taaatctcta ttctatttga gagttgctat atctgtttaa tggtttgata gactactcat 746641 ctttataatt tagagcaatt tttacaactt gttccgctgt gtaatcttca ttgctccaga 746701 aaattaaatc acttggtgcc ggataaggaa catttttctc taataaatcg agatattcac 746761 tgactttctc atcatctaat gttgggttca ttaattcctt tacaagaaag atcaactctt 746821 cttttgtcag tttatccatt gtttgccctc caatagattg tatctccatt gattttacaa 746881 atgactttat ttcttctgat aatgttatag gttgtttgca taatgataga taattgtctt 746941 gagaaaagtt agtctcatta tagagtttat taattgtatt tataacaata tattcatatg 747001 gaaaacctct aaaatatctt tattttagat tggtttataa aaaatagctc agcagagtag 747061 ggctgagcca ttttttaatt atagaccgag gtaactaatt acaaattctt tatcatcctc 747121 atcttcaggc aaaataccaa ggtttttata ttcccatatt gcgattcttt catatccatc 747181 taattctgag gctaaaatat catcataatt ataatctaat tggaattctc cgctacgatc 747241 caatgttagt gtaaggttag tccaaacatc atcgttatta tttctgtgtt cagttcttaa 747301 ttcttcaaaa agttctctta gttctcttaa caacgtcttg aaaatatcct tgcttacgtt 747361 gtaatggcta ggtatatctt gtgaataaat aatttgatta ttttctggtg ttctgaaatg 747421 aaaaagaacc attgtggaat catctaatac ttctgcataa agatatatct ttgtccattc 747481 accaggtatg atgtcattga gtttttctcc aataagttga tacaaatctt gcatcttcct 747541 agtttccatt cttctaaccc ccaggctgat ttttaataga gacgcttatt tcttttctgc 747601 tcccaatttt gtaggttaca tcgaaatatg atggtctaag tgaatcccca gaatagactg 747661 gttctatttg aactgctact tttttaggtg gttttttgct tagggctttt gcccactcct 747721 gctccatctc ataccatttc ccaccgctcc tattaatctg agaattcatc ggcacgatat 747781 tgtcaaactg gcctgagcct ttgaattggg tggcgattaa atggccgccg tcatcgtcag 747841 gctttcggtc ctggggcttt ccagcattcg tttgtgcata ttggtttcgt ttcgcttctc 747901 ccagctgcaa gtctgctttg acacttgtaa ttctaccata gttgtcagtc gtgtacgtgt 747961 agccttcttt tgttttgtag atgatattag gcttcagcac tttctttctg ctccatcttg 748021 cgaaatgctc gccgtatttg acggttaccg gcggtacatg tggcgctgga gttcgtcttc 748081 cgcttgatga cgttccgtat ggtttcggca ggatgacctt ggcgaatttt tgcagtcctt 748141 ctttaagcgt gaccccgttg actgcgttgt aaggaacgcc tgccggcact aaatcatgac 748201 ggggatgata cgggagaata tccgcaagtg tgagatctcc gatttgattt aacttggttt 748261 tgacgtgttt ttttgatact tcaatgcctg tgtttacttt ttgtttgatg tgatcaacgg 748321 tttgttttga gactgttatg gctttttggg ctgttgctga tttgcttgct gctgttttga 748381 ctttggtcgt cactttggcg gctgtgccag tttttgagac ggctcctacg ccttttgtgc 748441 cgacaattga tgtgacaaca gtgccaaccg catatgacac ccatcttgct cttgagtagg 748501 tgtcaccatt caccatgtct ttttgatacg attcttcgat tgccgctgaa atggcttcat 748561 acgttttgat cgggtgagcc atcgctccgg taatcgcttc aacggttcct cccggatctg 748621 tgaccatatc ccacaggcct acgaccgcgt ctttcccgga atcataaagg ccgacggcaa 748681 cccctttgaa gcctgcttca agctcacgcg tgttttcaat ttgggtgaag tatctctgtt 748741 gttcagctgt cagattttca tagccgatcg tttttgccat ttcgtagaat tcatcggcat 748801 ctgcataatc gtagtttttc agtctttctt tcagtttctc aatctcgcgt tccttcgctt 748861 cctctttctt aatcttcaag taagcctcag tccgcttttc aatgtcgcct tttttcttat 748921 gtatgtcact ctcacggtac gccttggcgt tgtagtggat gggtgtggcg tttttgcctt 748981 tacccgttgc ttcttggagc ttttggaagt cggatttgat gaattgttcg tttggttcag 749041 acagggcgta ttctgttttc aggtcttcgt ccaaggcgtc caatttttcc agtgtttttt 749101 tgcgtttgtc gttggcatcg gccagctcgt ctttgaaggt ttctgttgaa aacaggtcga 749161 gcgggaggat gtcgtcgata tcgtttagga tgtctttcat cgcttttttc tgttcggaca 749221 tgatggattt agatttttta ttggcatttg ccagttcgtg ctccaggaag gattcttcga 749281 tgtatgcgtc tgagaggcct ttgtcttcgg cggctccggc gatgctgttg aaaaatgcga 749341 ttttcatgtc gatgtagtcg atccactggt cggcgacgcc gacgtggtcg tgatagaatg 749401 ccttgatgtt gctggcgcct tttcctgaga attcactgtc actgagatca gcgactcctt 749461 ttaacgcttt tctcaagttg accatttgcg ttcttagttc tttgtactct tttgcacggt 749521 ctgtcgcttc cgaaagcagt gttttcgctt caaatacttt catgaccatt tcccttcttt 749581 tgttcgctca atatcaaaat tttaccacgg gtcgggataa ggtgggggtg agaacgtgtt 749641 ttggtggaaa aatgagtcat ttggcatgtg tctttattcg tggagggatt ggaggaaaca 749701 tggtcgaaat gatattgatt gctacacatt ttttggaagt ttgtattcta tattgttttt 749761 taaggagcat gttgatgacg aaaaaacgga ttacatttgg tttattagtt ttaatggtat 749821 gtgtcatcct gtttgttctg tatgttcagt tacgcaataa agatagtatt cctgtccaat 749881 cttccgccat tcaccccgaa gaagaccgca tcttttttat ttactccaat cctttcataa 749941 aagaaagcgt gctgctttca acctctacag gcgaacggtt taacaggcgt acgtttaagg 750001 tggcggatgt gccttatatt caaacgaaat cttatgcatc aacagacctt gtattattgg 750061 cggaacacga gcctttttac tacacgctgg agaaggatgt gatcaaagag catccgctgt 750121 cagatccatt tgcgttttgg tatgagggga aggatgtcac tattgaggcc tataatgttg 750181 atacgacggg aaatgagatc cacataaacg acagaaaaac gaaaaaggaa tataccctta 750241 ccttgcctcc gcttgtcaca atgggggcca gtgatgagaa ctttatttat atcattcaaa 750301 gcatgtctat ttacgtgatt gacagaaaaa cagaggaaat gattgagacc ctgagcttag 750361 cctcatacgc tgatcaattc gcagactcgg aggaatttat cgtcgcgagc tcggatcata 750421 aattgactgt gattgaaaaa gggacatgga agacgacata tattgcgtat cctgaagatc 750481 ttgaatatgc agatactgtg tactatgaca aagaaagcgg cagtttttac gtggcgtacg 750541 aggacaaaga gggtggagcg aacttgctgg aatatgggga ggatttttct attcacacat 750601 acagcttgaa attcccttat atggaggcga agtttaaggg gaatctattg tatatagttg 750661 cccaggaaga gcataaaaag ggcatcggcg gatacgtggg tgtgtttgat atccattcta 750721 aggagatgct ttatcagttt gatttgcctg aggaacaggt gaaggttcag gattttgttg 750781 tggttgacaa taagtgaata ctatatgaaa tagaatgaca aagacccttg cataaagggt 750841 tcttttttat gaaaaaaaca aattgacagg atgaaaaaac aatttcttcc ttctatattg 750901 ttttcaaaat ttgggattga tagaatatga catatctcat agagaaggag ggaagccgtt 750961 gagtcaagcc ataccgtctt cgcgtgttgg tgttaagatt aatgaatggt ataaaatgat 751021 tcgccagttc agtgttccgg atgctgagat tctgaaagcg gaggttgagc aggacattca 751081 gcagatggaa gaagatcagg atttactgat ctattattct ctgatgtgtt ttcggcacca 751141 gctgatgctt gattatttgg agccgggaaa aacatacggg aatcgcccta cagtgacaga 751201 gcttcttgaa acgatcgaga cccctcagaa aaaactcaca ggtcttttga aatactactc 751261 tttgtttttc cgcggcatgt atgaatttga ccaaaaagaa tatgtggaag cgatcggata 751321 ttatcgcgag gcggagaaag aactgccgtt tgtgtcagat gatattgaga aagcggaatt 751381 ccattttaaa gtggcagaag cgtattatca catgaagcaa acccatgtgt cgatgtatca 751441 tattcttcaa gccttggaca tttatcaaaa ccatcctcta tacagcatta gaacgataca 751501 aagcttgttt gtgatcgccg gcaactatga tgatttcaaa cattatgata aagcgctccc 751561 gcatttagag gcggcgctgg aattggcaat ggacattcaa aatgacaggt ttatcgccat 751621 ttctctattg aacattgcaa acagctatga cagatcagga gacgatcaga tggctgtaga 751681 acatttccaa aaagcggcga aagtaagcag agagaaagtg cctgatctgc ttccgaaagt 751741 cttgtttgga ttaagctgga cattatgtaa agcgggccaa acacagaagg cgtttcagtt 751801 catagaggaa ggattagacc atatcacagc acgttctcac aaattttata aagaattgtt 751861 tctgttcttg caggccgtgt acaaggagac tgttgatgaa cgaaaaattc atgatctttt 751921 aagctatttc gaaaaaaaga acctgcacgc ttacattgaa gcatgtgccc ggagtgctgc 751981 cgctgttttt gaaagcagct gtcactttga acaagcagct gcgttttatc ggaaagtgct 752041 gaaagcccaa gaagatattc taaaaggaga gtgtttatat gcctattaag aaaaaagtga 752101 tgatgtgtct ggctgttact ctagttttcg gaagcatgtc gtttccaacc ctgacaaact 752161 ccggtggatt taaggaatcg acagatcgaa atacgacgta tatcgatcat tccccttaca 752221 aacttagtga tcagaagaaa gcccttagct agggcttttt cttgctttac ggaagacgtt 752281 ccattttcca catcgcggca ttccttctat ttctaacgca agacactcga aacaaccaaa 752341 ccatttgagg tataatggat aaagtgaata acagtattta gattgatata tatgaaagag 752401 agtggaacat catgggccgt aagtggaaca atattaaaga gaagaaggcg tctaaggacg 752461 caaatacgag tcggatttat gcgaagtttg gccgtgagat ttatgtggcg gcgaaacagg 752521 gcgagcctga tccggaatcc aaccaggcgc tgaaggttgt gcttgaacgt gcgaagactt 752581 acagcgtgcc gaaaaacatc attgaacgtg cgatcgagaa ggcgaagggc ggagcggaag 752641 agaattacga tgagcttcgt tatgagggct tcgggccgaa cggatcaatg attatcgttg 752701 atgcgctgac gaataatgta aaccgtacgg cgccggaagt gcgtgcggcg ttcgggaaaa 752761 acggcggaaa catgggtgtg agcggatctg ttgcttacat gtttgacgcg acggctgtaa 752821 tcggtgtgga aggcaaaacg gctgacgaag cgcttgaaat cctgatggaa gcggatgttg 752881 atgtacgtga cattttagaa gaggatgaca gcgcgatcgt gtatgccgag cctgatcaat 752941 tccatgcggt gcaagaggcg tttaaaaacg cgggtgtcga ggaatttaca gtagcggagc 753001 tgacaatgct tgcgcaaagt gaagtaacgc ttccggatga tgcaaaggaa cagtttgaaa 753061 aattgattga tgcattagaa gatttggaag atgttcagca ggtatatcat aacgttgatt 753121 taggtgagta aggagtgagc aggctgttat ggcctgcttt ttttgtcccg gaaattgttt 753181 tagctgtatg taggcggccg cctatacgat ctataagata ttctcatact ctggactgta 753241 acctatgtga aggagagagt aaatatgact gatacaagac atatgtatgg cggacctggt 753301 tttggtcatt atcagggctt tggtattggc cacccgggct atggcatgca aagcacaggc 753361 tatccgggct atggcatgta tggaggccac ccgggctatg gcatgcaagg ctacccagat 753421 cacggcatac atggaggagt cggcggctat ccgggatatg gtgggtacgg cggttaccca 753481 agcggcggct atggaggctc tccgggaact ggaagctatc cgagcatgca ccatgaaaat 753541 gatggccatc accactatta tcaccatcat catgatggaa aagataatct tcatcaccat 753601 catcaccatg ttggaaagga taatcatcac caccatcatg atggtcatta tggccaccat 753661 catcaccata tgggccactg gggaaaagac ggttataaat aaagaagatg atgataaaaa 753721 gaggacactc ttgcagatca agagtgtttt tttagctttt ttcttgactg ttcagtctgg 753781 aaaatggtaa catttgtttc aggaggtgat cattttttgg ggaggaataa agaatttgat 753841 acggcgcttg ttcttcacag ggcgatagag gtttttggag agtatggcta cgaaggaacg 753901 tctcttcagg atctgctctc tcatttaggc attgcgcgcc aaagtttgta tgatacgtat 753961 ggaacgaagc gtgatttgtt tttgtccgct gtgaaatcgt atcttgaagg gaaaaacgct 754021 gccgttatgg aaaggcttga agcgccagga tctgtaaagg aagccattcg tgatattttt 754081 caggagggtg tcaatgccct gagggatccg gaacgggcga aggcgtgcta cattattaac 754141 agcgcgattg aacagatccc gcatgaccct gagcttgccc ggtattttga aagacaatcc 754201 aagcagcttg aggacgcttt ttatcacggg cttttaagag cgaaggatca aggagaattg 754261 aatggcgaag atactgatat atctgcgctt gctcggtacc tgaatcagag caggctgtca 754321 ctgacattta ttgcaaaagt gacggcagat atggatcggc ttcaggacca tgttgacgtg 754381 agtttatcag tgcttgatta acatgtggta aaggattctt tgcccatgta tgtacttttt 754441 ggactgaata gtctagaaat aaaaatgagg tgatgatgaa tgttgatgaa tgagtttgaa 754501 aaagcatgtg aaacattgag aaagtttatg gcttatatgc ttgagaagga catgaagagc 754561 tggacggagc tttgggatga gaatgctgta tttgagtttc cttatgcgcc ggagggatca 754621 ccaaaaagaa tagaaggaaa agcggccatt tacgattata ttaaagatta tcctaagcag 754681 attcatcttt cttcatttac cgctccgaca gtgtaccgtt cagcagactc gaatacggtg 754741 attgcggagt ttcaatgtga cggccatgtg attgagactg gactgcctta tcgccaaagc 754801 tatatcagtg tcatcgaaac gagagacggc cgcattgtgc gttataggga ttattggaat 754861 ccgcttgttg taaaagaggc ctttggagga tcatttttgc aaacagagga gagtgggaaa 754921 tgatgaaaca gaatccgatt ttaatcacgg gcgggaccgg cacagtcggc agccgaatcg 754981 ccagccgttt aataaagctg ggatacagag tgcgtattgc aagccggaaa aagggcgcgc 755041 ttgctgatgc tgagtatgtg tattttaatt ggaagtacgc ctccagtttt acgcctgctc 755101 tggaacaggt aaaacagatc tatcttgttg ctccggtcgg tgtatttgat ccggctccct 755161 atgtgcttcc ctttttaaag gaagcaaagc gtctcggcgc aaagcgggta gtgatgcaaa 755221 gtgcgtctgt tgtctccgag aacggtcccg tgtttggcgc gcttcaccag gcagtgcgcg 755281 agtttccaga atggacggtg ctgcggccct catactttat gcaaaatttc atcaatgtcc 755341 agcaccgcat gtctattcaa acggaggggc gcatcacaac ggcttcgggt gaaggaaaac 755401 ttgggtttat tgacgctgat gacatcgcag aaacagccgt cagggctttg attgatgatg 755461 ttcctcatca aacacatcat attctgacag gtcccgaggc gctgagctat gccgaagcgg 755521 cggagatcat tggagctgcg gcgggacgcc gggtggagca tgtcagcatt tctcgttccg 755581 agctgcagca taaaatggag gcaggaggtt tgcccgcgga ttatgcccat tttatggcga 755641 agcttgatga ggcaattagc catggtgcgg aacatcgggt aacggataca gtgaagcgtg 755701 tgacgggaaa agaacctcgt tcgctgtcag agtttgcggc tgctcatgct gcatattgga 755761 cctcattttg gactgaatag tctagaaaga ccttcggcgc ttccgaaggt cttcttattg 755821 aaaaagctaa gtcgtgtttt agtcataatc atgcctcctg cctcatacct attaaggtca 755881 ttgtttttga gaaaggagga gccggaatga aggatatgca gccgtttacg cctgtcaaat 755941 catatacgcc ctttcacagc cgttttgatc cctgtccgcc catagggaag aaatattaca 756001 gaacgccccc taacctttat atgacctttc agcctgagca catggagcag ttttcgccga 756061 tggaggcttt gaggaaaggc accctttgga aggatctcta tgatttttat gaaaaccctt 756121 atcgaggggg agacgcacat ggcaaaaaag gttgacgccg aatattatcg tcagctagag 756181 caaatacagg ctgctgattt tgtgcttgtt gagctgagtc tttatttaaa tacacatcct 756241 catgatgaag atgcgttgaa gcaattcaat caatattccg gctattcaag gcacttaaaa 756301 agacagttcg aatcctctta cggaccgctt ctgcagttcg gcaacagccc cgcgggcaag 756361 gattgggatt ggggaaaagg gccatggccg tggcaagtat aaggaggaat gcctgaatgt 756421 gggtgtatga aaagaagctg caataccctg tcaaggtcag tacgtgcaac ccgacgctgg 756481 cgaagtattt gattgagcag tatggcggag cggacggcga gctggccgcg gctctccggt 756541 atttgaacca gcgttatacg attcctgata aggtcatcgg ccttttaaca gatatcggca 756601 cggaggagtt tgcccatttg gaaatgattg cgaccatggt ctataagtta acgaaagacg 756661 ccacaccgga gcagctgcgt gaagctgggc ttggcgatca ttacgtcaat cacgacagcg 756721 cgctttttta tcataatgcg gcgggcgtgc cgtttaccgc gagctatatc caagcgaagg 756781 gcgatccgat tgccgattta tacgaagata ttgccgcaga agaaaaggcg cgggcgacgt 756841 atcaatggct gattgatatt tcggatgatc ctgatttaaa cgattccctg cgttttttgc 756901 gtgagcgtga aatcgtacac tctatgcgct tcagagaagc ggttgaaatt ttaaaagaag 756961 aacgggataa aaagaagatt ttctaatagg cagattggcc tctctttcat acaccctttt 757021 acatacagag aaaatggtct gtttttgcag tttggtctgc attataatca aggtgtgtgt 757081 gcaagcttac tttttgattg ggaggccttt atgacagctt ttaagattga gaacgaaacg 757141 attgcagatg gattttacgc gtgtccggcc gtctatgagg atgcagaatc gattaccggg 757201 ttgctcgtcc gaacagctga atggctccgg gatcggggtt ctaaccaatg gagcggactt 757261 ctcaaagggc aagatataca tgatatcacg gggtcaattg aaaagggaca tgtgtttgtg 757321 tttaaaaaag atgaagagct tgcggctgtc gtgatgctgc tgcctgcacc gagcgagtgg 757381 gaccggacgc tttggggaga cgatgggcat gaggagtcca tttatttaca ccgcctcgca 757441 gtaagccgcc ggtttgcggg acaggggctt ggagcccgcg tccttcagtg ggcggagacg 757501 ggcatacact ttccggaaaa aacgcggatc cggcttgact gtgtcgctga tagtgacgcc 757561 ctgcattcct tttatcggcg tatgggatat gaattcatgg gtgctgatgc gtccggatat 757621 catttgtttg agaaagagat tacggcagaa taagcgtcct ttgcaggggg cttttttgtc 757681 tttttctaaa agggaggcag gcgatgtgtg gtcaatatta tttgtgacag ggattgtgac 757741 ggcttgtctg tttgctggcg tatccgtatt gatgcggatg agatttcctg acaaaagtcg 757801 gccggaatgg atgttggccg ggctgatcgt ccttggtgtg tttgcgatct ggtacagcct 757861 cgtgtatgta cgcggctggg aaggggctgc gctcggaatg cttggattca atgtcatttt 757921 cggagccatt gccggatatt tgatcgataa ggccatccgg cgttacagga aaagataagg 757981 ctgctgccgt ctctcaacag gtcgaaattt tcacagaccg gcaggaattt tctttcgaaa 758041 ggagaaatac atattacttt aaaatgaaag cgttttccaa agcaggaagg tgatgttgat 758101 gatacacagt gtggcaaatg ggctgaatca tttttgtacg tgggtgatga gactggccta 758161 tttgaatgtg ctttggattt tgttttctct tgcaggcctg gttgtatttg ggctgatgcc 758221 cgctactgcc gcgatgttta cagtggcgag agaatgggcg aaggggaata cagatgcccc 758281 ggtgttttct gtcttttttc ggacgtttaa aaaggaatgg cgggcatcac agatcctcgg 758341 gcttatcgtt gtgacggctg ccctgtttct gtttgcggat atgcggatag cggctcagat 758401 ggaccagcct gtgctcgtca atgtattcgt gagcattagt ttgattttcg cgtttgttgt 758461 gctgtatgtg ttcccggtat tttctcattt tgacgtaaaa atcagagagg tgctgagcat 758521 cagctttttc attgccttca gtcgtccggc ggtgacgctt ttgatggcag cgggcgctgt 758581 cggtgtgctt tgtctcgttc tgtttcatgt cacgtttcta ttgtttttca gcgggagttt 758641 actcagcctg atcttaacga agctgtcctt taaagcgttt cggtcaatgg atcagcggca 758701 ggagaaagaa aaggcggcat gaagaaaaga gttgctggct ggtacaggcg gatgaagatt 758761 aaggataagc tgtttgtgtt tctatcgttg attatggccg tatcctttct gtttgtatac 758821 agcggggtcc agtatgcctt tcatgtgtat gatgagcaga tttaccgcaa gtcctcggag 758881 gtgcttcgga tgtcttctga aaggatcgaa gacgagctga agaagataga ggatgtgtca 758941 tatgaaatca ttacagacga acagattcag cgcatcctga gcatgcaaaa tcgggatgat 759001 acgtatgatc aatatcaaat gaagcaggag ctgtgggatc agcttgcggg atatgccagc 759061 gatgaaaagt acatcgattc cattcatgtg attgatgccc gcggctcaga gtattcagcc 759121 ggaagcagtt cttcagatct tttgcagcag gagcaggaag aggtatttaa gcgagcgaaa 759181 gcgaaaagtg gaagaaatct ttggatgacg ctcggcgggt cagaccccgt cctgatttca 759241 gcacggcaga tcaggtccta tcaccagctg agtctgaacg gcttgggcat ggtactgatc 759301 caggtcaatg taaaacagat gattcgtgat gtgccgaagg attggggcga ttcagtcgga 759361 gacattatga ttgctgacca aggcggtaat ttggtgtata cggcacatgc atcagcgcat 759421 gttcctgagg cagcaaaaga gacgttgaag caccccggtt atgacttgat aaaaaagaat 759481 ggcaaacgtt actttatttc ttatcttcaa tcatcctacc aaaattggag ctactataac 759541 gttatcccct ttgatcagat gttcgcaaaa atttccttta tgaaaacagt gatcggcaca 759601 tgctttcttc tctttttctg tgtggttttg cttttcggaa ggaaaatcgc caacagcatc 759661 acggagccga ttgaacagct tgtgaccgcg atgaaatcgg tacagcacag cggcattgaa 759721 gcaggtgtgt cgctttctct gccggaacat acacaggatg aggccggcat gctgaaccgc 759781 cattttactg tcatgatgaa acggattaat gagctgatgg aagaaaatgt ggaaaaacag 759841 ctcatcatta aagaaaccga attgaaagca ctgcaagccc agatcaatcc gcatttttta 759901 tataacacgc tcgagtccat caattggctg gccaaggcga atcagcaaaa gcaaatctca 759961 aaaatggtgg aatcgctcgg ttttcttctg cgaaacagca tacatatgaa gaaggatatc 760021 gtgaccattc aggaggaggc ggacattgta cgtcactata tgaccattca gcgatttcga 760081 tttgaagagc gcctgaaatt cacgttggat attgacgatg aggtgaagca ttgcctcatt 760141 ccgaaactga cgctccagcc gcttgcggaa aatgcgattc aatacgcgct tgaacccttt 760201 acaaggccat gcgccatccg gattcaggcg aaaaaggcga agggctgtgt ctgtattacg 760261 gtcgaagata acggccctgg catggatgga cggattcttg aatcaacggg tggaagagga 760321 atcggacttt ggaatattcg cgagcgcatc agcctgacat tcggagagcc atacggattg 760381 cggattcata gtgagcatga aaaggggacg aggattgtga tcacaatacc gtgccgaaat 760441 gaggtggtgt gatgtataaa atactgctgg ctgatgatga gaggattatc cttgatggaa 760501 tggcgggaat cattgagtgg gagtcgcttg gcgcctcatt gatcggaaaa gcgcagaacg 760561 gacatgaagc atatgaaaag attgtacata agcagccgca tatcgtcatc acagacgtca 760621 aaatgcccgg catggacggg cttgagctga tcaaaaaggt gtcagccgtc agcccgtcgg 760681 tgcaatttat cgtcctgtcc gggtttggag agtttgagta cgcaaaggaa gccatgaaat 760741 atggggtgaa gcattatttg ctgaaaccct gcaatgaaca gcagattatc agctcgctgg 760801 aggaaatcat tgctgagctg aagcggcaag atgtgcacaa aaagaaaaca gcccatctga 760861 aacacgagct ggaccatatc cgttcctttg cagccgatca atacttggaa ggcttgatcg 760921 ccggtgtggc ccagctttct ccgccgcctt cacttgccgg aaaaaagatc cgcctcttga 760981 tcttaaaagg ggaacaatct attgatgctg cagccagaga ggcactcgga tcggcactga 761041 cagcggtttg cagcagcggt gaatggaccg tgctcgccgt agaggagaac gccgctgaaa 761101 aggtggcgga ggtttttgcg gaccgcaaga tggccatcag tcaggcggga gaactccggc 761161 acgcggggca gctgtttcgt gacacagctg aagcgtctgg tgacctgcat gggagcgcag 761221 tgatttcaaa aatgatcagg cttattgccg acgagctcgg aaatccgaat ctgtccttaa 761281 aatgggcggc gaaggatatg ctgtttatga atcctgatta tctcgggaag ttatttaagc 761341 aggaaacagg cgagaaattt tcccaatatg ttacacgggt gcgtcttgag catgcgatga 761401 agcagatgaa aataaggagg gacgtgagcg tttcagaaat tgctgaagaa atcgggtttg 761461 gcgataatcc gaagtatttc agtcttgttt ttaaaaaata taccggtctg acaccgtcag 761521 aattcagaag aaaacaggga ggcgcttccg caggatagcc atctctgttt ttttgacttt 761581 cgccactgtt ttttgagtgt ttcgccctat ccgaacgctt taaaataaaa tgtaagcact 761641 tacattaaag gggggattgg tttgaagaag atttgttacg tgctgttatc ccttgtctgc 761701 gtctttttgt tcagcggatg ttcagcgggt gaagaggcct cgggaaaaaa agaagatgtt 761761 acactcagaa tcgcgtggtg gggcgggcag ccaaggcatg attatacaac taaggtaatt 761821 gaactatacg agaaaaagaa tccgcacgtc catattgaag cggaatttgc gaactgggat 761881 gactactgga aaaagcttgc gcccatgtct gccgccggcc agcttcctga tgtcattcaa 761941 atggataccg cttacttagc ccaatacgga aagaagaacc agctggaaga tttaacgccg 762001 tatacaaagg atggaacgat tgacgtcagt tcaatcgacg agaatatgct gtcgggcgga 762061 aaaatcgaca ataagcttta tggatttacg ctaggtgtca acgtgctgtc tgtgattgcc 762121 aatgaagatt tgctgaaaaa agccggtgtg tctatcaatc aggaaaactg gacgtgggag 762181 gattacgaga agctggcgta tgatcttcag gaaaaagccg gtgtctacgg ttccaacgga 762241 atgcatccgc ctgatatttt cttcccttat tatttgcgca caaagggtga gcgcttttat 762301 aaagaagacg gcactggcct cgcgtatcaa gatgatcagc tgtttgtcga ttactttgaa 762361 cggcagctga ggctagtgaa agcgaaaacg tccccaacac ctgatgaaag cgcacagatt 762421 aaagggatgg aagacgattt tatcgtcaaa ggcaaatcag cgattacatg gaactactcc 762481 aatcaatatt tgggctttgc ccggctgaca gactcgccgc tgtctctcta tctgccgccg 762541 gagcaaatgc aggaaaaggc gctgacactg aagcccagta tgctgttttc cattccgaaa 762601 agctctgagc ataaaaaaga ggcagcgaaa tttattaatt tcttcgtgaa taatgaggaa 762661 gcgaaccagc tgattaaagg cgagcgaggc gttccagtct ccgacaaggt ggcggatgcg 762721 attaaaccga agctgaatga ggaagaaacc aacatcgtgg agtatgtaga aaccgcgtca 762781 aaaaacatca gcaaagccga tccgccagag cctgtgggaa gcgcggaggt catcaagctg 762841 ctgaaagata cgtcagatca gattctgtat cagaaggtat cgccggaaaa agccgccaaa 762901 acgttccgga aaaaggccaa tgagatatta gagaggaata attgacggga aatggggctg 762961 acgcaatgaa aaaaagccgg agtataagaa aagacaatct ggcgggatat gcttttattt 763021 ctccgtttat catcgggttc ctatgcttta cggtgattcc gatgggggcg tccctgtttc 763081 tgtccttcac gagctatgac ttgtttacgg cgccgaaatg gatcgggctc gacaacttta 763141 aggaaatgtt tacgggtgac gaaaagtatt ggcagtctct gaaggtgacg tttacgtatg 763201 tgcttgccgg ggttccgctc cgcctcggct tcgcgctttt tatcgctgtc attttaaaca 763261 atgcagcaaa aggaacggcc atttacagaa cgctctttta tctgccttcg atcatcggcg 763321 ggagcgtcgc cgtggcgatt atgtggcgca atatttttgg caatgacggg gtcatcaatg 763381 cgctgctgtt ttttgtcggg attgatcaaa aaattctttg gtaccagaat ccgacaagtg 763441 cgctgtggac attgattctg ctgtccgtct ggcagttcgg gtcgtcaatg ctgatttttt 763501 tggccgggct gaaaaacatt ccgtcttcgt atttggaagc ggcaagtgtg gatggggcaa 763561 atcgggtgca gcgtttcttc aagatcacgc ttccgatcct tacaccgatt attttcttta 763621 acctagtgat gcagacgatt tctgctttta tgacatttac acctgcctat atcatttcga 763681 agggcgaggg cgggccgctt gacgggacac ttctctattc gctctatttg ttccagcgtg 763741 cgtttaacta ttttcaaatg ggctacgcat cggcgatggc gtgggtcatg cttgtcattg 763801 tcgggctgat tacgctcata ttgtttaaaa catcgtcata ttgggttcat tacgagtcaa 763861 aggaggaatg acggatggag ccggtcaacc agcctgtcag agaagccccg gtttttgaga 763921 gaaaaaaagc cgggcgcgtc agtcccaaac gcatactgtt ccatgttttt acggcaacgc 763981 tggcggtgtt gctgctgtac ccggttattt ggctgtttgt cagctcgttt aaagaaagcg 764041 ccagtatttt tacaacctca cattctctca ttccagaccc ttttattctc agtaactatg 764101 ctgaagggtg gaagggcatt gcgggacagc cgtttctgac gtttattaaa aactcggcga 764161 ttattgtcgg gctgtcaaca atcggtgccg tcatgtcatc ggctgtcatt gcgtacggat 764221 ttgcgcgtat accgtttaag ggaaaaaaat tttggtttgc gtgcatgatg gggacgttaa 764281 tgctgcctca tgaagtgttg atgattccgc agtatattat gtttgcgaaa ttagactggc 764341 tgaattcctt taaaccaatt gtcgttccgc aatttttcgg gcatgcgttt tttatctttc 764401 tgatgatcca gtttatccgg acgattcccg aggagctgga tgaagccgcg cgaatcgacg 764461 gatgcggacg ctttgcctgc ttttggcgga tcattctccc gctgattgcc cccgcgcttg 764521 cgacgtctgc gattttctcc ttctattgga agtgggagga gctgattcag ccgctcttgt 764581 atttgaataa gccggagctt taccctgttt cacttgcgct gaagcttttt ctcgatacag 764641 agtcggcttc gaactggggc gcgatgtttg ccatgtcagc cgtctcgtta ttgcctgtga 764701 ttcttgtttt ctttttgttt cagaaatata tcgttcaggg catcagtacg accggattaa 764761 aataaaaagg agtgttgcag atggcacagc ttatctttga tgaagaaaag gtgacgtcgg 764821 ttattgaccg gatcgtgaaa cggacatttc agatggattt tgcgtgggat tggccgggcg 764881 gcgttgcgtt ttacggtgtg gcggaggcct atgaagcgac ggaaaacgag gaatatatca 764941 atctgttaaa aacgtgggtg gatgaacagc tggaggatgg gctgccgccg ctttcgatca 765001 acggagtttc cattgggcat acgcttttgt tcctccacaa ggtgacaggt gatgacgtgt 765061 atttggaaac agcggccgag atggcggaat atgtgctgca taaggcgccg cgctttggcg 765121 agggtatcct tcagcatacg gtgaatgcgg cagaatacgt attccctgaa caggcatggg 765181 cggatacgct gatgatggct gggctgttta tgctgagaat cgggcgggtc atggagcgtg 765241 aggattattt tgaagacggc ctgcgccagt ttcacggaca tgaggatgtg cttcaggacc 765301 ctgtcacgaa tttgtactac cacgcctggg acaacaaagc gcaaaatcat ctgtcgggga 765361 tttattgggg cagggcgaac ggctgggcgg cactcacgat ggcaaaggcg ctcccgctta 765421 ttgaggtgac acatccttcc tttatgatca tcgacggatc gctcagagac cagctgagcg 765481 cgcttgtccg gcttcaggat gaatcagggc tgtggcatac aattttggat gatccggatt 765541 cttatctgga ggtttcggca tcagcgggta ttgcttctgc tctgatgtcg agcggaaagc 765601 tgtatacaaa atatgtgcag aaatcgcttg ccgccatttt ggatgcagtg gaagaggacg 765661 gacgggtcag cagggtatcg gccgggacag ccgtcatgaa aaatgccgaa ggatacaaac 765721 aggtgcctta caaacgaata caaggatggg ggcagggact tgcgctgacg tttcttgctg 765781 atgttttgaa aacgaaaaaa cgcttgtatc agtaaagata gcggcggggg gagagggatg 765841 aaaaaacagc ctcaacagaa ggaacgggtt tctcgctgga agggaacgta tttcaaaaga 765901 aactttgtct tcattttgct gattgcctgt attcccggat tgctgactgg cggcgcaatc 765961 tactttcttt cgatcgacaa ggtggagaaa gagctgcaga gatcgcatga aacacaggtg 766021 gcgcgtgagg tcagccgaat ggatgagaag ctgggagtgc ttgaactggc actcacccag 766081 atggcctacg attcttcact gatgaacgga ttggccgaga gggatttgga gaaagacttt 766141 acgttctcct atcaattaac gaaaaagctg tttcttttgc gggatcagca gccgctgatc 766201 gagcaggctt ccatctttct gaacagcccc cggccacttg tgctgagccc tgaatacagc 766261 gctttgacag aacaggaggc gcttcgcaag tatcgctcgc tgcttgcctc agaccacagc 766321 atttattgga aacggtcggg aaaccaagcg atgctgatcc agctcattcc gggcgcggcg 766381 gagaaaccgt tcggcgcgat catgctggcg gttgatccga aagaaatgga atcaatcctg 766441 caaagcttgt ccccctatcc tgatggcagt gcgttgcttt tagatcaaaa tcgagaggtg 766501 ctgtttcatg agggggaaaa agattttgaa aagactttac ttcatgagat aaaaaaacag 766561 cctgctgaga acggccattt tcagatggaa tggaaaggca aggtgtattc tgtctccttt 766621 ggagaaatga accggatgca tcagcaatgg acctttgtgt cagcggcgcc tctttcagct 766681 attacagcgc cgatggtgtt tttatcaaaa gtgatcatcg tgatgctggt catttgcatc 766741 ggtttggcgg tgtgcatgac atggtatgca tcaaaaaaaa tctatcgtcc catccagcat 766801 ttgcttggct tgtttaccgg aggagagaag aaaacatggc aggcgtccgg gcaggatgaa 766861 ttcaaatgga ttgaaaagag atggcaggat ctatcccttg aaagccggaa gctccaacag 766921 cagctcctgc ggcagacgcc ccatatgaaa aagagttttt tgcagcatct cttacagagc 766981 gatttttact atgacaacga ggaaagcctc agatttcgga tggaggaggc tggctggaac 767041 atcggcggaa acgtgtttca tgtgcttgat ctacaggtga cagggctccg ctgtgaaaaa 767101 agcatcttcc gtgaaggtga tgaacagctt gccgtgttta cactgactaa tatcgctgag 767161 gaattggcgg ctaaacgcgt ttttcagctc tccatacttg atatcggccg gctttctgtc 767221 accgttcttg tgatgaaaac aaacagctct gatctgaagg cgtatataac ggagctggca 767281 cgccaatttg gagatgtaac cggactatgc ctgacctcga cattgagcag caagacggag 767341 cgtgtcacgg aaattccttc tttatttcag gatgtgaaat gcggcaaatc ccgcaggaag 767401 tttgctaacc gggatcaggt cattgatttg caggccgact tccctcggga tgagcagttc 767461 gctccttatt acccttttga gctggaaaaa caaattgttc agaccatccg gctggaaaga 767521 aaacaggaag ccaaggaact gatagatgga tgtatgaagg aactgtcgga aaaagcggcc 767581 atagacaggc atgtgcattc cgccctgatt cagctgtttt cccgcattca ggaggatatt 767641 ttgcattccg ggctcaatcc cagcgaactg tttcagcacc ggaatccgtt tcttgatatt 767701 tcagaattgc gcgaacctaa cgaagcggcg gcctggctga tggatgtagt ggtgacgcct 767761 tacctttcca agcttgaggg cagaaaaaac agacagcaaa agcagctggc agaacgtgtg 767821 attgcgatga ttcacgaaca gtatatggcg gacatttcat tggaaagctg tgccgatgcg 767881 cttggcatga attcctatac gttaagcaag gcatttaagc aagtgaccgg cattaatttt 767941 atcgattatg tgacccagat cagaatcgaa aaggcgaaag aactgctggt caatacgaat 768001 aaaaaaattc atgatgtgtc tgaagaagtc ggctatcgcc acaattattt caatcggatt 768061 tttaaaaaac aggtcggcat gccgccgggt gtcttcaggc aaatgtatca ggaaacgccg 768121 tgaaaggaga gaacatgtga tgaagaaacc gattcaagta tttttagcgg gggattccac 768181 tgtgagtgac tgcccgcctc atgaagcgcc gatggcgggg tgggggcagg tattcgggca 768241 attgttttct gaaggtgtgc tggtccgcaa tcatgccaaa ggaggagcga gcaccaattc 768301 ttttgtggag gaaggaaggc ttcaagcaat tgccgagcac atcacacaag gcgattattt 768361 gttgattcaa ttcggccaca atgaccaaaa accgcggggg acgaagccgt actccacatt 768421 tcagcagttt cttaccttgt ttgcagatac ggcacgcgaa aagggcgcgc atcctgtgtt 768481 cgtcacatcg gtgcagcgcc gccgctttga tgaaaacgga cggatcgagc atacgctcgg 768541 tgagtatccc gatgcgatga aagcactggc gaaggagctc gatgtacctg tgattgatct 768601 gcttgcgaaa acaaaggtgc tgtatgaagc atacgggccg gaggagtcga agcgattgtt 768661 cgtttggttt cagccgaatg aacatccgaa ttacccggac ggcattgagg acaatacgca 768721 tttttcggaa aaaggtgcaa tggaggttgc gaagcttgtg gcagaaggca ttgaagagct 768781 cggacttccg cttaaggacc accttgtgag ccgggaggga aaagaacatg tataaggaag 768841 gcgcttgctt gtaccgcaat ccgctccggt ctaaaagcga tgtgaaggat tggcggatgg 768901 agggaggcgg acagatctca tttgacgatc acagcttgca cctgtcacat gtccaggatg 768961 aagcgcactt tgtcttttgg tgtccggaaa cctttccaga cggcatcatt gtgacatggg 769021 acttctctcc gatcgagcag cctggactgt gtatgctgtt ttttgccgct gcgggtattc 769081 gcggcgagga tttgtttgac ccaagtctca ggaaaagaac aggaacatac cctgagtatc 769141 attcaggaga tatcaatgcc ctccacctgt cgtatttccg cagaaaatac gcggaggaaa 769201 gagcgttccg cacctgcaat ttaagaaaaa gccgcggttt ccatctcgcc gcaatggggg 769261 ccgatccgct gccttctcca gacgacgctg attctccgta tcgtatgaag ctgatcaaag 769321 acaaaggcta tgtgcacttt tcaatcaatg gtctgcccat tcttgagtgg atggacgacg 769381 gcagcacata tgggcctgtg ttaacaaaag gaaaaatcgg gttccggcag atggccccca 769441 tgaaagccgt ttacagggat tttgccgtgc atcaagcggt gagaagatga agacgactgt 769501 aacggatgcg ctttatgcag gctgcgaagc ggtggtgaaa atagcatggc tcaacgggct 769561 gtggctgttg tttacacttt tgggcggcgt tcttttcgga tgggcgccga gcacagctgc 769621 gatgtgtgcc gttataagga aatggctgat ggggcaaaag gatgtcccga tattttcgtt 769681 atttctcgat acctataaaa aagagtttct caaggttaat gcgatcggat tggcgttttc 769741 ggctcttttg ctcatattgt ctgccaacta tcattatttt tctgccagta cgaattggct 769801 gtcctttgcc gtaacaagct gcacgctgct tgcagggctt ttgtatatca tcgcgctgat 769861 gtatgtgttt cccctttatg tgcattacca gctcccgctt cgcaaatata ttccgcaggc 769921 actgctgttt ggcgccatga gaccgctgac aactggctgt atgctgatcg ggtgcggatt 769981 tgtcctttat ttgctgtata cgcttcctgg cctgatccca ttttacggcc cgtgtttatt 770041 tgggcttgtg ttgatgtttt ttgctcttag gggatttcaa aagacggagg cccagcacca 770101 tcaagccggg taacaaaaaa atgacaaata agcaaaaaag tgcagtgtcc gaaataggca 770161 gatgcaaaaa agtgaaattg aagacagctc acaaagcgca taaaatccaa tttaagtaag 770221 cgcttacaga taaatgagaa ggagctgtct gatgattaga cgaaggaaac gcatgtttac 770281 cgctgttacg ttgctggtct tgttggtgat gggaacctct gtatgtcctg tgaaagctga 770341 aggggcagcg cggcagatgg aagcgctgaa ccgggggctt gtagcggtca agacggacgg 770401 gggcattttt gtcagctggc ggtttcttgg aaccgaaaac gcatctgttt tgttcaatgt 770461 gtacagagac gggcaaaaac tgaatgctgc gcctgtcaaa acaacgaact atgtggataa 770521 aaacggttcg gcgggctcaa cgtatacggt tcgggctgtt gtaaacggta ccgaacagcc 770581 ggcttctgaa aaagcctccg tatgggcgca gccgtatcat tccgtcccgc tggataaacc 770641 ggctggcggc acgacgccaa agggtgaatc ttacacgtac agcgctaatg acgcaagtgt 770701 tggcgatgtg gatggtgacg ggcaatacga gctgatcctg aaatgggacc cgtccaactc 770761 aaaagacaat tcacaggatg gctatacggg tgacgtgctg attgacgcgt ataaactgga 770821 cggcacaaag ttatggcgga tcaatctcgg caaaaacatc agagcgggcg cgcactacac 770881 ccagtttatg gtgtatgacc ttgatggtga cggaaaagca gaagtggcaa tgaaaacggc 770941 agacgggaca aaagacggca cgggcaaagt aattggaaat gccaatgcag attacagaaa 771001 tgaacagggg cgtgtgcttt caggccctga atatctcact gtgtttcaag gttcaaccgg 771061 gaaagagctt gtcaccgcaa attttgaacc ggcgcgcggc aatgtgtcgg attggggaga 771121 cagctacggc aaccgtgttg accgttttct cgccggcatt gcctaccttg atggacagcg 771181 gccgagcctg atcatgacca gagggtatta cgctaaaacc atgctagttg cctataactt 771241 cagggacgga aagctgtcaa agctttggac gctggactcc tcaaagtcag gaaatgaagc 771301 gtttgccgga caggggaatc acaacctgag catcgcggac gttgacgggg atggaaaaga 771361 tgagattatt ttcggctcaa tggctgttga tcatgacggg aaaggcatgt actcgaccgg 771421 cttaggccat ggggatgccc tccatacagg agatcttgat ccgggccggc cggggcttga 771481 ggtgtttcaa gttcatgagg acaaaaatgc aaaatacggc ttatctttcc gggatgctgc 771541 aactggaaaa atcctttggg gcgtttatgc cggcaaggat gtaggccggg gaatggctgc 771601 tgatattgac ccgcgttatc cgggacagga ggtgtgggca aacggttctc tctactcagc 771661 gaaaggggtc aaaatcggaa gcggggttcc gtcctcgacc aacttcggca tctggtggga 771721 cggcgatctg ctccgggaac agctggacag caaccgaatt gataagtggg attatcaaaa 771781 cggcgtatcg aaaaatatgc tgactgcatc aggcgcagcg gctaacaacg gcacaaaagc 771841 aacaccaacg cttcaggctg atctgctcgg tgactggcgc gaggaagtgg tgtggagaac 771901 ggaggacagc agtgctctgc gcatttacac gacgaccatt ccgactgagc acaggctgta 771961 tacgctgatg cacgatccgg tgtaccggct tggcatcgcc tggcaaaata tcgcctataa 772021 ccagccgccg cacacaagct tctttttagg agacggcatg gcggaacagc caaaaccaaa 772081 tatgtatacg ccttaactga aagggggaag gaacgggctg cgcgcagccc gttcccatca 772141 aatgaaacca aaaaagaggc aaatggaata cctgaccaga ggtttgattg cggtacagac 772201 agaacagggc gtgtttgtca gctggcgttt tctcggcacg gatcatgaga cgacggcttt 772261 tcacctttat cgggatggaa agcggatcac ccgcgatcca atcgctgaaa gcactaattt 772321 tctcgatcaa aacggaacgg ctgactctgt ttatcaagtg gcggctgtca ataaaggacg 772381 ggaagaaaag ctttccaaga aagctcgtgt ttggcaggaa aatgtcctgg aggttcctct 772441 tgccaaaccg gaaggcggtg tgacgccgga cggaaagccg tacacttaca gcgccaatga 772501 tgccagtgtc ggggatatag acggggatgg agaatatgaa atgatcctga agtgggaccc 772561 gtccaattca aaagacaacg ctcatgacgg ttataccggg gaggtgctca tagatgccta 772621 taaactggac ggcacctttt tgtggcgcat caacctcggc agaaacatca gagcgggtgc 772681 tcattacacg caatttatgg tgtatgacct tgacggtgac ggaaaagcag aaatcgccat 772741 gaaaacagct gacggcacaa cagacgggaa aggacatatc atcggtgatg agcaggccga 772801 ttttagaaac gaacagggca gaattttgtc cggtccggaa tatttgaccg tgtttaaagg 772861 agaaaccggt gaggcgctca cgaccgtgga atatgaaccg ccccgcggca agctggagga 772921 ttggggagac ggctatggaa accggatgga ccgttttctc gccgggaccg cttatttgga 772981 tggggagcgg ccgagccttg ttatggcgcg cggctactat acgagaaccg tgctcgtggc 773041 atacgatttc agaaacggaa ggctcaaaaa acgatgggta tttgactcca accagccggg 773101 acatgaagca tacgcaggac aggggaacca cagcttgagc gtggcggacg tcgacggaga 773161 cggaaaggat gaaatcatat acggcgcaat ggctgtcgat catgacggaa ccggcctgta 773221 ctcaacgggc ctcgggcacg gagacgcgat gcatgtaggg gatctggacc cgtcacgaaa 773281 agggcttgaa gtgttccagg tgcatgagga cgccacgaag ccgtacggac tgtcgctgcg 773341 agatgccgga accggtgaga tattatgggg cgtccatgct ggaactgacg ttggccgggg 773401 catggcggct catattgatc caagctacaa aggatcgctc gtctggggaa ttgatccgcc 773461 gggcaatgat ggcatgtcgt acgggctttt cacgagcaaa ggcgaaaaaa tcagcgacaa 773521 agcgccctct tcagccaatt tcgccatctg gtgggacggt gatttggtca gagaactgct 773581 tgatcatgac tgggacggaa cgatcggcag gccaaagatt gaaaaatggg atgctgaaaa 773641 cggctgtctg aagacgatat ttcagccggc cggcgtgttg tccaacaacg gcacgaaagg 773701 aaacccggtt cttcaggcca acctgttcgg agactggcgg gaagaagtga tatggagaac 773761 ggaagacagc agcgcgctcc gtatctatac aacaacacat ctcacccgcc actgctttta 773821 cacgctgatg catgatccgg tttacaggct cggcatcgcc tggcagaata ccgcctacaa 773881 ccagccgccg cacacgagct tttacctcgg aacgggaatg aaaaaaccgc cgaagcccgc 773941 cctgtacata gcgggaagca aagcggaggc gccgctgtag gaggactaag ggataagacg 774001 caaaggctga acgctacgcc aagatgatta gagaactggc aggacgaacc aatgctcaag 774061 cgctgtacgc accggttttt tcaagggaag agctatccgt gatggaagct gtataaaaaa 774121 cgaggaggaa tgaaaaaatg gcaaatcata tttatcttgc cggcgattcg actgttcaaa 774181 cgtatggaga cagcacaaat caagggggct gggggcagtt tctcggctcg catctgccgg 774241 agcatattca agtgatcaac agagcgatcg ggggaagaag ctcgaaaaca tttgtggaag 774301 agggcaggct tcaggcaatc ctcgatgtga ttgagccgga tgattggctg ttcgtgcaga 774361 tgggccataa tgacgcgtca aaaaataagc cggagcgcta caccgagccc tatactactt 774421 ataaacaata tttaaagcag tatatcgcag gcgcgcggga aaaaggcgcc catccgcttc 774481 tcattacccc cgtagcccgc tttcattacg aaaacggcgt gtttttgaac gattttcctg 774541 attactgcat tgccatgaag cagacggccg ctgaggagaa tgtccagctc attgatctga 774601 tggagaaaag tctcgctttc tttactgaga agggcgagga aaaagtgtac acctatttta 774661 tgatttcaga agggattaac gattacacgc attttacaaa aaaaggcgca aatgaaatgg 774721 cgaaacttgt ggcaaaaggc ataaaggagc tcggcctgcc attgacagaa tcgatcatca 774781 aagaaaggtg aaaatgtgat gagaaaactg tatcatggcg cttgctatta tccggaatta 774841 tgggatgaag agacgattca gcaggacatt gacatcatgc gtgaagttgg cgtaaatgtt 774901 gtgcggatcg gcgaatttgc ctggtcagtc atggaacctg aagaaggaaa aattgacgtc 774961 ggttttttca aagaaatcat cgcccggctg tatgatagcg ggatcgaaac gattatgtgc 775021 acgccgacgc ctaccccgcc gatttggttc tcacatggcc ggcccgaacg catgcatgcc 775081 aatgaaaaaa gagagatcat ggggcatggc tcccgtcagc atgcctgtac gaacaacccg 775141 tatttccgaa aaaaagccgc catcatcacc acagccatcg ccaaggagct tggccggctc 775201 ccggggctga tcggatggca gctagacaat gagtttaaat gccatgttgc agaatgcatg 775261 tgtgagacat gcttgcgcct atggcatgac tggctcaaaa atcgctacgg ggtaattgag 775321 cgcttgaatg aagcttgggg aaccgatgtg tggagcgaga cctatcagac gtttgagcaa 775381 gtcccgcagc cgggaccggc cccgtttctg catcatgcct ctctacgcac tatgtatcag 775441 ctgttttcga tggagatgat cgcttcgttt gcggatgaac aggccaaaat catccgctgc 775501 tattcagatg cgccgatcac gcataacgga tcagtcatgt tcagcgtgga caatgagcga 775561 atgtttcaga atctcgattt tgcctcctat gacacgtacg cttcgcagga aaacgcctct 775621 gcctttttat tgaactgtga tttatggaga aatctgaaac aagggcgccc gttttggatt 775681 ttggaaacga gtccgtcgta tgccgcctcg cttgaaagct ccgcttaccc gcacgcagac 775741 gggtatttgc aggccgaagc cgtatcgtcc tacgccttag ggagccaggg gttttgctac 775801 tggctatggc gacagcagcg ttcaggcagc gagatttccc acggttcggt tctcagtgcc 775861 tggggcgaac ccaccatcgg ctatcaaaat gtgctggcgg ttgagcgggc aagaaaggaa 775921 atcgagccta ttattctatc gactgaaccc gttcaagccg aggcggcgat gacttactct 775981 gacagagcaa aagcatttat taaaactgag cctcaccggg gactccggca tcgttcgctt 776041 gtgacgcatt tttatgaacg tattctcaac acggggattc accgtgacct tattccggaa 776101 ggcgctccac tggacggcta tcgcttgctg tttacgccat ttgtgccgta tttgtcttct 776161 gaatttatca aaaaagcttc ggcattcgct gaagcgggcg gcatctggat caccgggccg 776221 ctgacaggag gacgcacatg cgagcatacc attcataccg attgcggact tggcgaactt 776281 gagaaaacgt cagggatcaa aacacttttt acctttccga tgaatgagaa cgtgaataca 776341 ggaaaagcgt ttggcatcac ggcgccgctc ggactgtgga gcgcggtgtt tgacacagag 776401 agcggaaaca cccttggcac ggttgaagca ggaccggggg cgggccatgc ttttctgacg 776461 gaacggaatt acggcgaggg gaaaattgtc atgctgggct cgcttccatc cgggaaagaa 776521 ggggatgcga tgctggaagc gctcgtcagg cattatgcgg aggaagctgt tatttccagc 776581 cggtcggatg tgacacccgg cacgatcgtt gccccgcgta taggcgaaaa cggccttgtg 776641 tggatcgttg tgaatatgga tggaaaaggc gggagcgtga cattgccgga atcgggaacg 776701 gatttgttga cgcaccgctt ggaaaaggcg gggagactgg cggtcggacc gcatgaatac 776761 cgtgtgattc aatttgacaa tcacagctga ttctttgtat cgaatcagct tttttctatg 776821 gagggagaga cagatgaaaa agatcaaatg gttatcagga cagccaaagg tgacaagcgg 776881 cgtgacgtgg ggcatgccat ggaaaaaagg agaattaaaa aaaggagacc gtctggcgct 776941 tatgaatgaa aacgcggaaa cgcgatatgt gcaaagcgaa ccgtcggcct attggccgga 777001 cgggagcatc aagtggacga agcacgcggc ggtgtttggc ggtcaggaaa accaaagctt 777061 tacagtgcac aaaagagaag tgccgcagcc aactgaatcg ctcagcattc ttgagacaga 777121 gcatgatatc caagtggata caggagcact cgtttgtacc attcataaaa caggatctga 777181 tttcattcaa tcattgcaga tcaatggaaa gccgatcgcc gcaggcggga ggctcgttgc 777241 gataagagaa acgagaaaag agtcagcggc gaaaatggtt cttttgcatg aaaggtctgt 777301 cagctttatc aaacgggcgg cgattgagca gagtggtcct gtcaaagcag tagtcaaaat 777361 cgagggagtg catgtgcttc ataaaacgta tgaggaatgg ctgccgtttg tcatccgatt 777421 aacgttttat gccgggctgt ctgagatcgg ccttgtgcac acgcagctga ttgacaggag 777481 cggtaaacta gaattcgtta aggggctcgg catcgaattc gacctttttt tggagggaga 777541 gccgtacaac cgccatttcc gctttgcggg agagaaaggg atgtataaag aacccgccca 777601 gctgtttggc acacgtaaat tcaatgaacg atatccgctt tatgaaaaac aaatcaatgg 777661 cgaaatgctg tctccagatg aagagcataa ggaatggttt gcacatggca cacagaatgc 777721 ggtttgggac gatgtcaaga tcgtgcaaga ttccagcgat cattacagcc tgtcaaaacg 777781 gaccggaaaa gattatgcgt gggttggaat gctgcatggc agccgggcga aggggctctg 777841 ctatgcgggc ggaaaaaatg gcggtgtggc tctcggcctg cggtatttct ttgagaaata 777901 tccttcagca ctggaaatca caggtcttgc cggcagccgc cccaaaatga ctatctggct 777961 ttggcctccg gacggcgaag cgatggattt gcggcattat acaggaaaca ctcacgtggc 778021 cagcgcgtat gaaggctttg atgaaatgcg ctctgatccg acaggcattg cgaacacaaa 778081 tgaaataagc ctggcgtgct tttcgcacat gccgtctgac gaagtcctca atgcgctggc 778141 tgacaaatgg caggcgcccc cgctcattgt atgcgagccg gacgtctatt acgaatcaaa 778201 agcactcggg gtatggagca tcattgacac atcccatccg ctcaaaaaag agctggaaga 778261 acagcttgat gcggcctttc tgttttataa aaaggaagta gagcaacgca gatggtacgg 778321 tttttggcat tatggcgatg tcatgcatac gtatgacccg atccggcata tgtggcggta 778381 cgatctcggc ggatacgcat ggcaaaacaa tgagctcgtt ccgaccctat ggctgtggca 778441 ggcgtttttc cgctcaggca gagaggatat cttccgaatg gcagaagcca tgacccgcca 778501 tacgagtgaa acggacagct ttcacctcgg tgaatatgcc gggcttggct cacggcataa 778561 tgttgtgcac tggggatgcg gctgcaagga agcgagaatc agcatggccg ggcttcataa 778621 attctattat tatctgacgg gtgatgaccg gacgggagat cttttgacag aagtgaagga 778681 tgccgattat gcccttgtca aaaccgatcc gatgcgcgct ttttacgaga aaggcaagca 778741 cccgactcac gccagaacgg gaccggactg ggcggcgttt tgctcgaact ggctggcgga 778801 atgggagcgg accgaaaatt cggaatatct caaaaaaatc gaaacgggaa tcaactgtct 778861 gaagcggctg ccgctccgct tattatctgg cccgacattt gaatatgatc cggcgacctc 778921 gatgcttcat catatgggag acggcattgc gggcggatat catatgatca ttgccttcgg 778981 cgcgccgcaa gtgtggatgg agctggctga gcttcttgat gactgggaat gggaggatat 779041 gctgagtgaa ttcggcgaat tttacacact cagtgatgag gaaaaacgaa aaaaaagcgg 779101 aggcgctctt catgacgggc attttcactg gccgatgttc gccgccggta tgacagccta 779161 cgccgcaaga aaaaagcaag atcctcatct cgccgccaaa gcgtggaatc ttttgctaga 779221 agataagctc agccatacgc cgcttccgat caaaccggag cgcatcgaga catggacgca 779281 gctagaggag cttccatggg tgacaacgaa cactgtctct caatggtgtt taaatgtcat 779341 agcggcgctg gaactgatcg gagattccct tccggcaaaa aaagaaacat cgggcaaaaa 779401 aggataacag ccggaatttc ataggagaaa tggtgcaaaa aatgaagatt gcaagaattt 779461 atgtaagcgc tttatattga gaggggcaaa ggggaaatgc aaattgaaaa aagggggact 779521 tacgcaacat gaaaataaga atgcgaaaaa aatggatggc cttgccgctt gctgccatga 779581 tgatcgccgg atgcagccat tcggaaacat ccaattcagc aagcggttcg aaagatacga 779641 tcaaaattat ggcgccgctc ttatcgccgg aaagcccaag tgataagagc ccttcattaa 779701 aagcgctcga aaaatacaca ggcaaagaga ttaaggtcac atgggtgcct gattcatcct 779761 acaacgacaa attcaacatc gtcatggctt caggagagat gcctcacgcg attgtcatta 779821 aagataagtc agccggcttt atcaaatctg tcaaagcagg ggcgttttgg gagctgtctc 779881 cttatttaaa agactacaag aatttaagcc aggcagatga aaagattttg aagaacagct 779941 cggtgaacgg cgaggtgtac ggaatctaca gaacgaggga tctgatcagg gcgtgtatga 780001 tcatcagaac cgactggctg aaaaatgtcg gtctggatat gccggaaacg cttgatgatt 780061 tctatgaagt gctgaaagcc tttaaggaaa aagatcctga cggaaacggc aaggatgata 780121 cgtacggcat ggtcgtgccg aaatggatgg gactcggcaa cggaagccca tgggatgttc 780181 tgcaaatctg gttcggcgct ccgaaccgct acggtgttga aaacggaaag ctgattccag 780241 attttacaac gaaggaatac atggatgcgc tcacgttttt taaaaagctc tatgatgagg 780301 gcttgatcaa taaggacttt gctgtcatgg attctgcgaa gtggaatgat ccggttgtaa 780361 aaggaaaagc gggtgtcatc gttgatacag gctcaagagc gtctcaaatc caaagcgcga 780421 tggaggaggc ggatgagtcg aacaaggata tcattgatat cgtcggctcg cttgagggac 780481 cgaatggcaa gcgcaccttc ccgacatctg gttattcagg catgatcacg ataccaaaat 780541 caagcgtcaa aaccgaaaaa gagctgaaag aggtgctgtc cttcctcgat aagatgaatg 780601 ataaggaagc gcagattctc acgaacaacg gagtgaaggg ccgcaattac gagctcaagg 780661 acggcgtatt cacctcactt gaaaaaaaca ataaatctct cctgtatgag catgaaggct 780721 tggcacagtt cagcatgtcg attccgaaaa gcgagtatta catcgaagac cagaaaacca 780781 agctcttcca gcatcgcaag gacatcataa ccgaaggaga aaaaatagcc gtctttaacc 780841 ctgctgagtc gcttgtatct gatgtctata cccaaaaagg agcccagctt gacaacatca 780901 tcctcgacgc gagaacacaa tttatcattg gagaaattga tgaaaaaggg ttcgatgatg 780961 cggtggagct ttggaaaaaa agcggcggca atgaactgat gaaggacttg aacaaattgt 781021 accaatcgtc aaaataaacc gatgcgcctg cctttcggcg ggcgccccgg tatcacgaaa 781081 ggagaacaga tatggaaaca gtgccgaaga agagagatgc acctgttctc accgctggaa 781141 aaggcatcag ctggatggct gcgctcaaac gggacaaatg gctttatctt cttcttattc 781201 ccggtctgct ttatttcttg attttcaaat acttgccgat gtggggtgtg ctgatcgctt 781261 ttaaagacta ttcgccatat ctcggcttct ggaaaagcga atgggtcggc tttgattatt 781321 tcaaagactt ttttatgaat ccggattttt tccggctgct gcgcaacacc ctcatgctgg 781381 cgagtctgga tcttttgttt gcctttcccg cgcctctcat tttggctctg cttttgaatg 781441 aggtaagaaa ggccgtgtat aaaagatgta tccaaacctt tatttacgta ccccattttg 781501 tatcatggac aattgtggtc agcatcacct tcgttttctt tactgtcgat acaggtgtga 781561 tcaacaaatt gattatgagc ctgacaggtg agcagatttc tttcttgtcg gatgcagact 781621 ggttccggcc aatgattgtg atgcaaagca tttggaagga gacaggctgg ggaacgattc 781681 tatttttggc agcgcttgct acggttgatc aagagcagta tgaagcggcc atcatggacg 781741 gagcggggcg gttcaggaga atgtggcata ttacgctgcc ggcgattaga agcaccatta 781801 tcgttttgtt gattttaaga atcggcagct ttttgaatct tggctttgaa caggtgtatt 781861 tgatgacgaa ctcactcaac cgcagtgtgg ctgacatctt cgacacgtat gtgtacatga 781921 tggggattac ccaaggggcg tatagctaca gcacggcggt cggtttgttt aaatcagttg 781981 tcgggattat cttgattttt ggcgccaatt acattgcgaa aaagtttgat caggaaggat 782041 tgttttagag gagggagagg tatggctgaa attcacacga tgcacaacac caaagccgga 782101 cgggtgtttg acgtctgcaa cattctgttt ctcggcggtg tcggcgcgat taccattttg 782161 ccgtttttat atattatcgc cggttccttt gcgacagaag cggaactcgc ccagcggagc 782221 ttctttattt tcccgaaaac ctttacactt gatgcttaca agtatgtgtt ttcgacaccg 782281 acgttccttc gaagcatggg cgtgtccatc ttcatcacgg tggttgggac ggctgtacag 782341 ctgtttttta ccttcacgat ggcgtatccg ctggcgaaac ggcatgtgaa gggacggaat 782401 ctgctgttga atctggtgat tttctccatg ctgttttcag gcggcatgat tccgacgtac 782461 cttgtcgtaa aatcacttgg ccttttggat acgtattggg cattgattct gccgatggcg 782521 attaatccgt tcaaccttat tattatcaaa aacttctttc agcagctgcc gcgcgagctg 782581 gaggaatcag caaaaattga cggctgttcc gaaatcggcg tcttctggcg gatcgccctg 782641 cctctgtcaa agccagttat tgcgaccttt gcgctgtttt atgcggtcgg gatttggaat 782701 gatttcttcc acgctctctt atatatcaat gacagtgcaa aatggccgct gcaaatggtg 782761 cttcgccaag tcacaatttt atcggattta acggcgacca atggtgatac gatgcaaaat 782821 gcagttccgc cggagcaggg aattaaactc gctgtcattg tcattgcgac gctgccgatt 782881 ttggcggtct atccattttt acaaaaacac tttgcaaaag gaatgctgat cggttcggtg 782941 aaaggctgag aaagggagtg tttcatatca gtacattaga tcagattaag attgcctata 783001 tcggcggggg gtcccaaggc tgggccagaa gcctgatgag tgatttgtcg attgatgaac 783061 ggatgtcagg cacggtggcg ctctatgatc ttgattttga agccgctcag aaaaatgaag 783121 tgatcggcaa tcacagcggg aacggcagat ggagatatga ggctgtttct actttgaaaa 783181 aggcgttatc agccgcggat atcgtcatta tttccatttt gccgggatca ctggatgata 783241 tggaagtcga tgtgcacttg cctgagcgct gcggtattta tcagtctgta ggtgatactg 783301 tcgggcctgg agggatcatc aggggcttgc gtgctgtgcc gatatttgcg gaaattgccc 783361 gggcaataag agactacgca cctgaatcat gggtcattaa ttatacaaac ccgatgtctg 783421 tctgtacaag agtgctgtat aaagtgtttc ccggcatcaa agcgattggc tgctgccacg 783481 aggtattcgg gacgcaaaag ctattggcgg aaatggtcac ggaaaggctg gggattgagg 783541 tgccgcggcg tgaggatatc cgcgttaatg tgctcggcat taaccatttt acatggatca 783601 caaaagcctc ttaccgccat attgacctgt tgcctatatt ccgtgaattc agcgcgcact 783661 atggggaatc aggatatgag ctggaggggg aatgctggag ggacagcgtc ttttgttcgg 783721 cacaccgtgt tgcgtttgat ttatttgaaa cgtatggcgc catccctgct gcgggtgaca 783781 ggcatctggc agagtttctt cccggcccat acctcaaaca gcctgaagta tggaaatttc 783841 atctcacacc tatatcattc agaaaacaag acagagctga gaaacgacaa gaaacagaac 783901 ggttgatcgt gcaacaacgg ggcgttgctg agaaagcttc gggagaagaa ggcgtgaaca 783961 tcatagcggc tcttctcgga ttgggtgaac tcgtcacaaa tgtaaatatg ccgaatcaag 784021 gccaggtctt aaaccttcct atacaagcca ttgtcgaaac aaacgcattc atcacaagga 784081 accgtgtcca gccgattttg tccggagcgc ttccgaaagg tgtggaaatg ctggcggcta 784141 ggcatatatc caatcaggag gcagtggcgg acgcaggttt aacaaaggat actggcctcg 784201 cgtttcaagc cttcctcaat gacccgcttg tccagattga ccgcagtgat gcagagcagc 784261 ttttcaatga catgctccaa tgcatcatgc aaagctgagc ttgccgatta gctctttccg 784321 gtttagaaag gaaagcattg accatactga tagtataatc aagaagtagg tgctatcaat 784381 atgggaaatt atttaagtgt tgcggtagaa ctggtctgcg gtttaggcat tttatttatc 784441 atcttaaagc ttctcgggaa aacccaattt tctcaaatta cgccgtttga ctttatttct 784501 gctttaattt taggtgaatt ggtcggaaat gccgtctacg atcatgaaat caaaatcaaa 784561 gaaattattt ttgcttcgct attgtggggc gtgctgattt atattattga atttatcacg 784621 caaaaaatga aatcatcgcg aaagttcttg gagggcgagc cgaatatcgt catccgcaaa 784681 ggggagcttc aatataaagt aatgaagaaa aataagatag acattaacca gctgcaaagc 784741 ctattgaggc aagctgggag cttttcgatc caagaagtag aatatgcgat tcttgaaaca 784801 aacgggatgg tcagcgtgct tccaaaatca gactttgaca aaccgacaaa taaggatttg 784861 cagattcctt cgaagtccgt ttctctgccg atcacgttaa tcatagatgg agagattgtg 784921 cgggataatt tgaaggaagc aggtgtggat gaacagtggc tgaaacaaga attgaaaaag 784981 aagaacattg ataagacaga ggacgtgtta tttgcagaat ggcataaaaa taagccgctg 785041 tatactgtaa cgtacgaaca aagcagatca acatgactct tagaaaaaag cttgcagcaa 785101 ggcgcaagct ttttattgat tgtatgtccc ttgtttgaca gcacgtacat ggtacatgct 785161 cacttcagtg ctgatcagat agtcaggctt tggtttgcct ttgtttgctt tatggccggc 785221 gatatgcgca tcgctttttt cccattgctt ccagtgatcc tctgattccc agcgaatcat 785281 gacaacaact tcttcatcac cgcggcgcac atttttctca agcactgtca catcaattaa 785341 accttcttgt ttttcaatga ttccttcagc gctgaaacgt tctatgactt tatctgcaaa 785401 gccttcttta accgtcattt ttctcaactg tacaaacatt tgtctcactc caatcattct 785461 cacatatgaa taattgtaaa tgaaattcat tctcaatgtc aaagaaagcg cagggcggaa 785521 tcgaaccgcc gtgcgcaaca gtttattctt ttaataaaaa cacatttccg tcttcgtcct 785581 taaattgaac gaaggtgccc cactccattt gattgggctc accgagaaat tctacaccgt 785641 ttgtcttcat tttctcgtat gtaccaaaga tgtcttcgca ttcaaacaca atagaagcct 785701 tcatttgctc tgagcctttc atcatggctt tcgggtaaat gactaaacga gtctcggctc 785761 cttttggcgc aacctccagc cagcttgctt caggtcccat tgggtgatcc gctgcaatat 785821 caaagcctac cttctctgtc caaaattgct tcgctttctg ctggtcctcg acatatacag 785881 caacagtgcc aatttgtttg atcataggga aacctccaag ttgaaaagat aataatacta 785941 taacctgttt acggccgaag taacataaaa aaatcagccg ggaaaccggc tgattattaa 786001 aatgagcagc ttacaacatc gatgtgattt gtgtctaagg cgaaataaac ccagcggcgc 786061 cgtgaggaat cccaataaaa gccgccgacg gatcttctgc caaggatgat cgggtaaaac 786121 caaaatgagc ggccattggt taaccagaca taggtaaatc ggaaaaggca aggacgaatg 786181 gtgattggtt caactaacaa aacggctcct tgagaaccct gcggttttgg gggtttcgct 786241 ggtatttggg aaggaggagg tccctgcggc gcaccgccga agcctgggct ggcaccgctg 786301 ccaataccag ggccggagcc gccgccaaag cctggaacag caccaccgcc aatgccagga 786361 ccggagccgc cgccagagcc cggaacagcg ccgctgccaa tgccaggcca tggatatcgg 786421 tattcatatt caaaagcagg ccaaggctca taaaaatgcc ccgcaaacat ataaggatca 786481 acataataca tgtgataacg tcctttctca ttgtaaactg tacattgcag tttatgcggg 786541 cggactctta ttggtgcatt cgcctaagga tatgaagctg gaatgctctc agagagcaga 786601 atcatttgat ttttctctag tcttattcac aattccgatt tatcatttta taatgaaagt 786661 gcttctatta cgaaaaagga gacagaccgt gaatatcgat caattattat atcaatatat 786721 catagacaac actgcggata ttactgagaa atggttcagt ttgcgttgcc agctaaaagg 786781 cgagctatat tccgccagcc atttaagtga agaaacgaaa acacttttaa ccgagcagca 786841 tacatttacc aatataacaa tcgcaagcgc atttctggag gatcaaaccg attttcaaga 786901 aaacatgaca aaatgggcgc aaaacgttgc gaaaaacagg gtagagcagg atgttcaagt 786961 gcatgaggtc gtagaagcca tatccaattc aagaatctca ttctgggacg cagtcgccac 787021 atttataaaa gagaatcagg agattgtgac aaatgaggat gcagaccgat ggaaccgcat 787081 tgtgaatcag tcgttcgata agctgattat tgaattctcc gagcagtacc aaaaattcat 787141 gctgatgagg cttacatctc agcaggaact gatctcagag cttggctgcc cggtcatttc 787201 cattgccgat ggaatcggga tattgccgct tatcggctcc attgatacaa aacggcacag 787261 gtcattttag aaacagtgcc ggtccgctgt gtcgagagaa aaatcacaag cctcgtcgtt 787321 gatctttcgg gtgttccgat tgtggatacc atggtggctc agcaattgta caacctgtct 787381 aaaacacttt tcttattagg cgtcaaagcc gtattttcag gaattcgccc ggatgtggcc 787441 caaacatcga ttcaattggg gcttgatttt agtgaatatg aaacgtacgg cacgctgaag 787501 caggcattag aaaacatggg tgtccgctgt attgttgagg aattggaaga aaacaaatag 787561 gaagtttcca ggcatatgat tgtccgtcac cgggtgatca tatgcctttt tgatttgaac 787621 agaaatcacc attgatttat cgaaaaaaac ataatattat aattcttata agaatactgt 787681 gaattaaaac ctattcaaca ggggggaagg tcttttggtt tctaaatcaa cgattgatcc 787741 ggaagtgatt gaaaaaatca tcagctcgct ggaaacactc gatttcggca cggttcagat 787801 tacggttcat gattctcaga ttacccaaat tgagaaaata gaaaagcacc gtttttcgct 787861 gaaaaggaaa gaatcaaaat gataatgtaa agggcgtttg ttttcattaa attctcctta 787921 aaacatatac atatttcatc caatttttat ataatagacc tttaagatca ttttttagga 787981 ggatttttga catgcaagct acggttcacg agagtaagca atcgatcatg caacgcattt 788041 tgacagtctt tgtcttcaca ttgctgatcg cgactgtcgg cctttttatc ggccaatttg 788101 ttcctgtcgc tttgatgctg ccgctttcta ttcttgaagt ggcgatgatt attctggcct 788161 tctggatgcg cagaagaaaa gcggtcgggt atgcgtttgt atatacattc gcgttcgttt 788221 ccggcattac cttatttccg atcgtcagcc attacgcttc catcgccggc gcctatgtcg 788281 tgctcgaagc ctttggctct acatttgtca tttttgccgt cttgggcaca atcggcgcaa 788341 aaatgaagaa ggatttatcc ttcctgtggt cgtttctgct ggttgcggtg ctcgcactcg 788401 cagtggtagg gattttcaac attttcagcc cgttaaactc agcggcgatg atggcgtatt 788461 ccgtgatcgg aaccatcgtc ttttcccttt acattttgta tgatttgaac caaatcaagc 788521 accgccacat tacggaagac ttgattccgg ttatggcgtt atcgctgtac ctagacttta 788581 tcaacttgtt catcaacctg ctccgcttct tcggcatttt gagcagtgat gattaatgaa 788641 aaagcgtctg tcattggata ggcgcttttt gccatacatc aaaaaggcag gtggagtatt 788701 ggtgaaaaaa caaatgggcg catatgtatc tctggcagca gctatggcga tcgtcggcag 788761 ttctgtcgtt gtcggcaagc tgatggtcga acggattccg gtctttcttt cctcaggatt 788821 gcgttttttg atcgcttctg tcgtattgct catgctgctg ttttgcattg aaaaagggtt 788881 tccggctttg acgaaaaaag atgtgttcgt attactggtg caatcattca caggcgtgtt 788941 tttgttcagt atttgcctgc tgtatggggt tcaatatacg acgggaacgg aaagcggcat 789001 tttgacaagc acaaccccca tgttgatcgg tattttatcc tttttcctgc tgagagaaaa 789061 aattgagaaa aagacgctga tcggcatttt gctggcggtt tgcggcgtaa tggcgattaa 789121 tttgtttgga gccgggagcc aagacgggac gccgcacgcc ttattcggga acatgctgat 789181 cattgctgca gtcattggcg aagcgttgtt tacattgatg gccaagctgc tatccccgca 789241 tatttcggca ctggcgattt cgaccttcgt atcgctcttc ggcttcctgt tttttctccc 789301 gtttgctttg tttgaggcct cttcatttga ttacagcgtg ccgactgttt tggattggtc 789361 gtatgtgctg tattacgcgc tttttgtcac tgttttggcg ttttacttat ggtatagcgg 789421 ggtgacgaag gtgccggcgg gtgtatcggg cattttcaca tccgttcttc cggtctcagc 789481 tgtcattttg tcaggcgtga tattgaagga gccatttgag tttgtgcatt tcatcggcat 789541 tgcatgtgtc atcggcggca tatttgttac ggtcataaag aaaaaacagc cggatgcgta 789601 tccggctgca gaagaaaaga cgctatagcc tgtccggatc ggacgggttt tttagtcttt 789661 aaacacgctc agcctttcaa aaagatcacc aagcatcttc acgaacatgt ctttttcctc 789721 gtcgctgtag ttttccatga cagcggatat tttgctgaaa tggccgggca gaaattgctc 789781 caggcgtgct ttgccttctg ttgtcagttc aatgctgatt tttcgtttat cctctgtgtg 789841 atgcctgcgg ctgacaaaac cgtctctcgc cagcccgtct agcaggcctg taattgttgc 789901 tttcgtgaca tttgaccgct tggcaagctc tgtcggactt aacctatgat ccttggcatc 789961 aaagagcagc atcaggattt tgaattttcc ttctgaaagc cctcggccag caaagtaatg 790021 ctccatcaca tgattcattt tttttgaaat atcaaaaaga gataaaaaca attcaagaga 790081 gccggcgtca atattggcat acgtttcggc gtgctctgtt atatgcttat atttcggtaa 790141 atgttttaat tccatcgcaa ttagctcccg tacattcgtt gtgacacgat tataaaggag 790201 ggaaaaccat aacgcaactt ggcttggaga tgattgacag cttttcttgg gacatagtaa 790261 ggtaatatag ttaggcgcct aactaataca tatagagctg aaaaggtggt tattgatatg 790321 aaacatatgt taatagcagg aggcggaatc ggcggcttgt cagcggccat ttctctccgt 790381 aaggcagggt tttccgtcac cttatgtgaa gcggcttcag aaaatcgaaa aacaggtgcg 790441 gggattcttc agccgcaaaa cgcactggcg gtgttgaaag aactgggcgt attcgaagat 790501 tgctgtaagc acggctttca aacagaatgg tttaaaacgt ttgatgaaca ggggaatttg 790561 ctgtttcaag tcagtgaatc ctttttagac gattcacttc cgggacgcaa taatatcctg 790621 cgcaaaacgt taaatgacat tctcatgaag catgccgagg cagtgggtgt agacatcaag 790681 tgggggaaaa aggttgtcgc ctatgaagaa actgctgaat cggtcactgc cttatgtgaa 790741 gatggagaaa agatgcaggc tgacattctg gcgggctttg acggcattca ctccgttgtt 790801 cgtgataaga tgctgcaaaa ggaaacggaa aaagagcatc tcggcatggg agcgtggcgc 790861 ttttatatcg aacttcctga ttacacattc gaggacgcaa cattcatgta tagaagcgga 790921 gacacacaaa tcggggtggt gccattggca caacacgctg gctatgtctt cgtcctccag 790981 ccttgcacga gcgattactg ggatgaggaa gatacccggt ttgatagagt aaaagagatt 791041 ctttctggtt ttcgggggct ggattttgtc acaaagcaca tgtcaaaaca gcatcctgtc 791101 atctttaaca aactggagca ggtcgccgtg caggagccat ggcataaagg ccgcgtcatc 791161 atcggaggag acgccgccca cgccggtgcg ccaaccctgg cacaaggagc ggcaatggcg 791221 atcgaggatg ccatcgtcct cgccgaagaa ctccaaaacc acgccgacca cgaaacagca 791281 ttacaggcgt actataaaag aagagcccca cgagcgctca aagtccagaa cctatcatct 791341 gaaatcgtcc gccgcaggct gaaaggagag ccgggagcgg aagaactgat tggggagtgc 791401 tatgcggtgt tgagggaagg gtattaaata ggaaaagtcc agaaagtgat ttctggactt 791461 tttagtcttg ctctgtttta ttccttatcc gctcaatcac ctcatgcagc ccctcaggct 791521 tataaaactc caccggtgaa ctgcctttct caaacgaaat cgtctcggct tcaatcagcg 791581 cgacatagcg cccgtttact tttgcgagat gaatagaatc gccaaaatcc gctagcaatc 791641 ccttaatctc tgtttctccg actttcattt tcagctgggc ctctggcgtg tgctcgatga 791701 tttgggcgga ggcttcgatg acttgatggg tgtcgaggcg ctcttggatt tcccgttttt 791761 cgcttgcttc ccaaatctca atgtcgtgct cgaactgctt gagttcttcg ctgttgtctt 791821 caaatgtctc gtagacgtgc tcttgtacca tgttcatgac ctgatttttc atgatttctg 791881 gcatcgattc tccgtactcg acgaatttca gaaagtcctc aaaatagcgg gcgtgcgagg 791941 cctggtggat tttcagttca ccttcctcga ccattccttc ctctggcatg tacgggtatt 792001 ggatgctttt catgtttttt gtcgtgatcg ccatttcgac ttttttaatg agagaagacg 792061 cgtcagagat gcgggcgacc ttcggctcaa aatcacattt cataatgaag acaaatgact 792121 catcaaagta ttttctcggc acggccgaag cgacgagaaa cacgccgccg cgaaccgcgc 792181 ttgtgtcaag gtacgtgcgg acgaactgct cgctcagctc attgaagtct tcttttgttt 792241 ccgccagacg cgcgcggttg aacatgttgt agtttgggtt ggaatcgagc tcgtggccgg 792301 gctcgacgat aaaatggccg attttcgtcg gcacctgctc ggactgcgga tggcggtcgg 792361 ctttccgttt aacgattttt ttcagttccc cgtcgagaaa gtccttcagc tcgctttctt 792421 caaattctcc cgtatcaagg gtctggaagt gcttgaactg cttgttcgcc tgctcatctt 792481 tgccttccac ctgtatgaca taaaaggata aaaaccgaat ttcaaaatcc atatataaac 792541 tcaccttatt cgcgtattgt acagcttctc aagtatagaa aaaacagcga tcatgcgtca 792601 attgggagaa cggaataatc atgaccatga aagggaaatg tagtcaaata gaaggcattt 792661 catacggaaa ggaatggttc gatgaaggaa acaagcccga ttcctcagcc gaagacgttt 792721 gggccgctcg gcaatttgcc tttaattgat aaagacaaac cgacgctttc gctgatcaaa 792781 ctggcggaag aacagggccc gatttttcaa atccatacac ccgcgggcac gaccattgta 792841 gtgtccggcc atgaattggt gaaagaggtt tgtgatgaag aacggtttga taaaagcatt 792901 gaaggcgcct tggaaaaggt tcgcgcattt tccggtgacg gattgtttac gagctggacg 792961 catgagccta actggagaaa agcgcacaac attctgatgc cgacgttcag ccagcgggcc 793021 atgaaggact atcatgagaa aatggtcgat atcgctgttc agctcattca aaaatgggca 793081 aggctcaacc cgaatgaagc agtcgatgtc ccgggagata tgacccggct gacgctcgac 793141 accattgggc tatgcgggtt taactaccgc tttaacagtt actacagaga aacgccccac 793201 ccgtttatca acagcatggt gcgggcgctt gatgaagcga tgcatcaaat gcagcggctt 793261 gatgttcaag ataagcttat ggtcagaaca aagcggcaat tccgctatga tattcaaacg 793321 atgttttcgt tagtcgacag cattattgca gagcgcaggg cgaatggaga ccaggatgaa 793381 aaagatttgc tcgcccgcat gctgaatgtg gaagatccgg aaactggtga aaagctcgac 793441 gacgaaaata tccgctttca gatcatcacg tttttgattg ccggccatga aacaacgagc 793501 ggcctgcttt cctttgcgac ttacttttta ttgaagcatc ctgacaaact gaaaaaggcg 793561 tatgaagagg tcgatcgggt gctgacggat gcagcgccga cctataaaca agtgctggag 793621 cttacataca tacggatgat tttaaatgaa tcactgcgct tatggccgac agctccggct 793681 ttcagccttt atccaaaaga agacacagtc attggcggaa aatttccgat cacgacgaat 793741 gacagaattt ctgtgctgat tccgcagctt catcgtgatc gagacgcttg gggaaaggac 793801 gcagaagaat tccggccgga acggtttgag catcaggacc aagtgcctca tcatgcgtac 793861 aaaccattcg gaaatggaca acgggcctgt atcggcatgc agtttgccct tcatgaagcc 793921 acacttgtgt taggcatgat tctaaaatat ttcacattga ttgatcatga gaattatgag 793981 cttgatatca aacaaacctt aacacttaag ccgggcgatt ttcacatcag tgttcaaagc 794041 cgtcatcagg aagccattca tgcagacgtc caggcagctg aaaaagccgc gcctgatgag 794101 caaaaggaga aaacggaagc aaagggtgca tcggtcatcg gtcttaacaa ccgcccgctt 794161 ctcgtgctgt acggctcaga taccggcacc gcagaaggcg tcgcccggga gcttgctgat 794221 actgccagtc ttcacggcgt aaggacaaag acagcacctc tgaacgaccg gattggaaag 794281 ctgccgaaag agggagcggt tgtcattgtg acctcgtctt ataatggaaa gccgccaagc 794341 aatgccggac aattcgtgca gtggcttcaa gaaatcaaac cgggtgagct tgagggcgtc 794401 cattacgcgg tatttggctg cggcgaccac aactgggcga gcacgtatca atacgtgccg 794461 agattcattg atgagcagct tgcggagaaa ggcgcgactc ggttttctgc gcgcggggaa 794521 ggggatgtga gcggtgattt tgaagggcag cttgacgagt ggaaaaaaag catgtgggcg 794581 gatgccatca aagcattcgg acttgagctt aatgaaaacg ctgataagga acgaagcacg 794641 ctgagccttc agtttgtcag agggctgggc gagtctccgc tcgctagatc gtacgaagcc 794701 tctcacgcat ccattgccga aaatcgtgaa ctccagtccg cagacagcga tcgaagcact 794761 cgccatatcg aaattgcatt gccgccggat gttgaatatc aagagggcga ccatcttggc 794821 gtattgccaa aaaacagcca aaccaatgtc agccggattc ttcacagatt cggtctgaag 794881 ggaaccgacc aagtgacatt gtcggcaagc ggccgcagtg cggggcatct gccattgggc 794941 cgtcctgtca gcctgcatga tcttctcagc tacagcgtcg aggtgcagga agcagccaca 795001 agagcgcaaa tacgtgaact ggcgtcattt acagtgtgtc cgccgcatag gcgcgaatta 795061 gaagaactgt cagcagaggg tgtttatcag gagcaaatat tgaaaaaacg aatttccatg 795121 ctggatctgc ttgaaaagta tgaagcgtgt gacatgccgt ttgaacgatt tttagagctt 795181 ttacggccgt taaaaccgag atactattcg atttcaagct ctccaagagt gaatccgcgg 795241 caagcatcga tcacagtcgg tgtcgtgcgc ggcccggcgt ggagcggccg tggcgaatac 795301 aggggtgtgg catcaaatga tttagctgag cgtcaagccg gtgatgatgt cgtgatgttt 795361 atccgcacac cggaatcccg gtttcagctt ccgaaagacc ctgaaacgcc aattattatg 795421 gtcgggccag gcacgggagt cgcgccattt cgcggtttcc ttcaagcccg cgatgtttta 795481 aagcgggagg gcaaaacgct cggtgaggct catctctatt ttggatgcag gaacgatcgg 795541 gattttattt accgagatga gcttgagcgg tttgaaaaag acggaatcgt cactgtccac 795601 acagcctttt cccgaaaaga gggcatgccg aaaacatatg tccagcatct catggctgac 795661 caagcagata cattaatatc aatccttgac cgcggtggca ggctttatgt atgcggtgat 795721 ggcagcaaaa tggccccgga tgtggaggcg gcacttcaaa aagcgtatca ggctgtccat 795781 ggaaccgggg aacaagaagc gcaaaactgg ctgagacatc tgcaggatac cggtatgtac 795841 gctaaggatg tctgggcagg gatatagata aagaagactg gagacatcca gtctttttag 795901 tcctttcgaa aaaatggtga tcgcgctaaa cattgatgca tacaataact tcagtccgcc 795961 ggaagggcgg gctgtctgca aaacctattt ttcgtttttg ctagtttatg ttattcttat 796021 actcggtatc tatttctttt ttcaaaggca cacatgacaa aagaaatcct ttttttattt 796081 ccgagaaaaa aatgtgaaac gaaatgaagg tttctttcgt ccagtgattg gtttccaaat 796141 ggttgtaata aaaatgatat ggtgcgaaac ataaatattc cggcttgccg cggtgtattt 796201 attgttgtgt gatgccttga ttttgtttgg aaagaaggaa ttggaaggca ggatataaag 796261 agcaggtaaa tatgaatgaa gaacttaaag tgtttaagaa agtagaggtt gccatgaaga 796321 aacttttttc ttacaaactt agcttttttg tgctggctgt tatactgttt tgggcaaaaa 796381 cgtatttatc ctacaagact gagtttaatc ttggggtaaa aggcacaact caggagatcc 796441 tcctgatatt taacccattc tcaagcgccg tcttcttttt aggactggct ttgctggcga 796501 aagggcgtaa atcagccatt attatgctga ttatcgattt cttgatgaca tttgtgttat 796561 atgcaaatat tttattctat cgtttctttg acgatttctt gacgttcccg aacattaaac 796621 agtccggaaa cgttggaaac atgggagacg ggattttcag tatcatggcc ggtcatgata 796681 ttttctattt cttagatatt atcattttga ttgcggtatt gatctggaga cctgaattaa 796741 aagaatacaa aatgaaaaaa cgctttgcat ctttagtgat cctttctggg atcgcactgt 796801 ttttcatcaa cctgcactat gcggaaaaag accgtccgca actgctgaca agaacgtttg 796861 accgcaatta tattgtgaaa tatttaggtt tatacaacta caccatttat gacggtgtac 796921 agacggctca aacagagacg caaagagcct atgcaagcag cgatgattta acaagtgtcg 796981 agaattacac gacgtctcat tatgcgaaac caaacgccga gtacttcggc tctgccaaag 797041 gcaaaaatat cattaaaatt cacctcgaaa gcttccagtc attcctgatt gactacaagc 797101 taaacggtga agaggtgacg cctttcttaa ataaacttgc gcacggcggg gaagatgtga 797161 cgtattttga taacttcttc catcagacag gccagggaaa aacatctgat gccgagctga 797221 caatggataa ctcgatcttc ggtcttcctg aaggctccgc gtttgtgacg aaaggcgaaa 797281 acacctacca gtcgcttcct gcgattttag accagaagga aggctataca agcgccgtcc 797341 tgcatggtga ttacaaatcg ttctggaacc gtgaccagat ttacaaacat atcggatatg 797401 acaagttctt cgacgcaagc acgtatgata tgtcagatga aaatgtgatt aatatggggc 797461 ttaaggataa gccgttcttt acagaatcga ttccaaagct tgaatctctt aaacagccat 797521 tttatgcgca tttgattaca ttgacaaacc attatccgtt taaccttgat gaaaaagacg 797581 cgtctcttaa aaaagcgaca acaggcgata acacagttga cagctacttc cagacagcgc 797641 gttaccttga cgaagcgctt gagcaattct tcaaggagct gaaggaagcc ggcctgtatg 797701 acaactcagt catcatgatt tacggtgacc ataacggtat ttctgaaaac cataaccgag 797761 cgatgaaaga gattcttgga aaagagatca cagattatca aaacgcacag aaccagcgtg 797821 tgccgctgat gatccgcgtt cctggcaaaa aaggcggagt gaaccatacg tatggcggcg 797881 aaattgacgt catgccgaca cttctgcact tagaaggaat tgattctcag aaatatatca 797941 actttggtac tgatttattc tctaaagacc acgacgatac ggtggcattc agaaacggag 798001 acttcgtaac gccgaagtac acatcagtcg acaatatcat ttacgatacg aagacaggtg 798061 aaaaactgaa agcgaatgaa gaaacgaaga atctgaaaac aagagtgaac cagcagctga 798121 gcctttcaga cagtgtcctg tacaaagact tgctgaggtt ccataaacta aatgatttca 798181 aagccgttga tccgtcagac tatcattacg gcaaggagaa agaaatcaaa taagatgaaa 798241 aagagccttg agcgggcgca ttgccttcgc tcaaggctct ttttttggtt atacaaccaa 798301 cttgaaaaaa tagattccat ttggtcacca aggctggctt tctctcatat cattacagta 798361 gattttgaaa ccggattgaa atcggacaaa ttatcgggga aatgccttga tagattgtga 798421 agatgtacca ggtttcgaac tcaatattca tagagatgag gggtagagat gaaagcggtc 798481 attctctgcg gcggaaaagg aacgagaatg agtgaagtca cgaatgacat tcctaaaccg 798541 ctcgccatga taggcggcaa accgattcta tggcatatta tgaaaattta tcagtactac 798601 ggagtaaacg agtttattct gcttttgggc tataaaggag aaaaaatcaa ggaatacttt 798661 ctcgactatg aatggaagca caacagcctg acactcgaca gctctacggg agaggtacag 798721 atgctggggc agcctgaaac gtggaaaatt acgtttttgg agactggggt agatacgctg 798781 acagccggaa gaatcttgca ggcgaaagac tatatcggtg atgaaacatt tctgctcacc 798841 tatggagacg ggctggccaa tatcaatctt ttccatctca tcagctatca tcagacaaaa 798901 ggtgctgccg cgactgtcac cggcattgac aaagtctcgc agtttggcac cttgacagtt 798961 gaggatggca tggcgaaaac attttctgag aagacatcaa gtgatggaat catcaacggc 799021 ggattcttcg ttcttagtcc aaaggttttc gattatttgc cgaaggacgg gaacacgatg 799081 ttcgaagatg aaccgctgaa gaaccttgcc aaagatgggg agcttgctgt gtaccgccat 799141 tacggatttt ggacggccat cgatacgtat aaaaatctct tagaagtcaa caaaatgtgg 799201 aatcaaggac aacaagtatg gaaggtatgg tgaattgatt tgagtttctg gaaaaataaa 799261 aacgtatttg tcacgggatg cacaggtctt ttaggaagct atttggtgaa agagctgatc 799321 gaacagggcg caaacgttac ggggctagtc agggatcatg tgcctcaatc caatctttat 799381 cagggagaac atatcaagaa aatgaacatc gtgcggggct ctcttgagga cttggctgtg 799441 attgaacgcg cgcttggcga gtatgagatc gacacagtct ttcatcttgc tgcacaagcg 799501 attgtcggcg tggcaaaccg caacccgatt tctacctttg aagcgaatat cctcggcacc 799561 tggaatattc tcgaagcctg ccgcaagcat ccgttaatta agcgggtcat tgtcgcttca 799621 agtgataaag cttacggcga tcaagaaaac cttccatacg atgaaaacat gccgctgcaa 799681 ggcaagcacc cgtacgacgt ctcaaaaagc tgcgcagatc tgatcagcca cacctatttt 799741 cacacgtacg ggcttccggt ctgcattacg cgctgcggaa acttatacgg cggcggagat 799801 ttgaacttca accgcatcat tcctcagacg attcagcttg tgctgaacgg ggaagcgccg 799861 gaaatccgaa gcgacggcac atttgtacgg gactacttct atattgaaga cgccgttcag 799921 gcttatctgc ttcttgcaga aaaaatggaa gaaaacaatc ttgccggaga ggcctttaac 799981 ttcagcaatg agatccagct gaccgtactt gaactggtag agaaaatatt aaagaaaatg 800041 aacagtaatc tgaaacctaa ggtgctgaat cagggaagca atgaaatcaa acatcaatat 800101 ttatccgcgg aaaaagcaag aaagctgctg aattggacac cggcctacac tattgatgag 800161 ggacttgaaa aaacgattga gtggtatacg gaattcttca aaaagtaatg tgaaacgagg 800221 tgaacaagac tgtgaccagc gcgtattgca ccgttttatc aaaaggaaga ttatatcagg 800281 cagtcgcttt gtttaagtcg ttagagcaag ttgatcaaga cagtcccatt tttatacttt 800341 gcatggatga agatacgcac cgcgtgttac agaagctgaa gatgaagcag ctgaaccttg 800401 tgccggtggc cgctcttgaa aatgaattgc tgctgaagct gaaggaaact agagatcaaa 800461 gtgagtattg ctggacgatg aagccgatct ttctgcaagc tgtgctgaac agcaatcctg 800521 agctggagcg tgtgacgtat attgacgggg atctcttttt ctatgcagat ccatcgccga 800581 tttttgaaaa ccagccggac tgctcggtgt tgctttcacg aggggatatt gtaatccctt 800641 cttttgagaa agagcagatt gacatgctgc agcgtctttt aggcagatat aattccgggt 800701 ttatcagctt caagcatgat gatgcaggca cggattgctt ggagtggtgg aaggaacgct 800761 gtcttgagga atgcaaaaat gcaccgggtg aagggaaatt cggtgatcag ggctatttgg 800821 attatatgtc tgagctgttt ccgaatgtgt gtgacattac aacacccggc gtgaacatcg 800881 gccattggaa ttatggacag catacgtttt cctggaaaga tggccggatc gtgctggagg 800941 atggcagtcc gctgatcttt tatcatttca gcggataccg aatcgtcagc atcaatgaaa 801001 tcaaacagat tcatgaaaca acccgcacag atctgccgtt tgtgcatgaa ctgtatcaag 801061 agacactgcc gcatatcatt cagcacatgc aaacgttaga ccctgaattt aacggttttg 801121 cttcaaaaga tgacaacaaa taaatgagta aatacaggaa gtgaaaatga agtgaaagca 801181 agcgttatta ttcctgcata taattcgaag gagcgtcttt acaacagcct tctgtcatta 801241 aaccagcagg agtgcgatga agaatttgaa gtcattgtag cggacaatgg ctctgaggac 801301 gggacgctct cgatgcttga gtcatttcaa gctgattttc cgctgatctt tacacggatt 801361 aaagaaaaca ggggcattgc gtacggacga aatcaggcgc ttcgcaatgc cagaggagac 801421 atcctgattt tccatgacag cgatatgctt gcggcaaagg accttgtggc aaaacatatt 801481 aaagcccatg agaacgaaga gaatctcgtc gtgtgcgggt tgttttggaa acggatctac 801541 agtttttact atgaacgatt tgaagaagaa cataaggaac agctcgcaaa gctcacaggt 801601 gaaatgccga agaaagacaa acaaaagctg ctggaggaag cggacatcaa aaacggaagc 801661 tttcttgata aaagctttga cctcgatacc gactttatag acgtgctcaa gaagatttta 801721 gatgagtacg gcgatgactt gaaaggctat catatgccat ggcgcttttt tatcacgaat 801781 aattcctctg tgaaacgcaa gcatgtggtt gacctcggtt tatttgacga aggcattgtg 801841 cggtacgggt ttgaggatta tgacctcggg atcaggcttc atcaggccgg attgaccttc 801901 aggcttcgcc gtgatattgt cagtgttcat caggaacatc caagcaattg taagtctgta 801961 gacgatattc gggcaaacat tgcctatatg tgcgataaat acaataacat ccgctcctta 802021 gacgttcatc tcgcttttaa tgggccgttc ccgcctgaca tgacgaacag aatcatggct 802081 gatattcaaa agctgctgga atcacagaaa tatgatatgc tgctgaatct gtttcttgag 802141 cttctgcatg ttgttaaaga gcgcaacatt gatccggatt ggcgaaagaa atccccaagg 802201 gtgacggcga aaagctttga tttgcaaact gtccgcaagc ttctgcctaa ggcgaagaaa 802261 aagctaggcg tgaacgattt tgccaacgca ctgtatgcgc ttgtcaacga tttgctgcac 802321 gtggatctta gatcattgga tgtggtataa gtgagtacat ttcatttttc aacgatagtg 802381 tcaaggacac atatctttaa gctcatgcct atgattcatt ctctccatga gcattgcgat 802441 gattttcatt tatatgtgct gtgtgtcgac cagaaagcgt atgaattgct tcagcacgtt 802501 ccatgggagc atgtaacctt tgtgcagctg catgaaatgg aagacccgga gctgttgaaa 802561 gcgaaaagca acagaacgtt tcatgaatat tgctggacgt taaagcccgc ctttttgttt 802621 catgtgatga gcaagtggga tgacgctgaa tactttgccc atatggatac ggatctattt 802681 ttcttttctg atccggcacg tatttttgca gaaaacccaa cggcgtctct gtatttgact 802741 gatcatcgta attcgccgcg cttcatgtcc tactacgacc gaaccggacg ctttaataca 802801 ggctttgtcg gcgccggtaa tacaaaggaa gcatatgaag cggtgtggca gtggagacag 802861 gactgtattg aattttgcac ggtcgaaatg gatacggaac gaaagacata tggtgatcaa 802921 agatatgtgg agaaatggcc ggagcagttt aaaggtgttc atgttgtcaa atccatagga 802981 gccaatacag cgctttggaa tatcgaaaac tataaggtcg ggcaaaagga cggccgcgtg 803041 tatatagatg aaacgccgct gattttctat catttctctg ggtttacgct ggtgacagaa 803101 aaagagttta atctttgctg gtactaccgg attgaagacg aagcgacaat taagatgatt 803161 tatatgccct atatattaaa tctgaaaaga tggattgatg aaatacagtc ggcgtttccg 803221 gactttgcgg atggctttat cccgaagcac gcagtgcctg acactcattt tatccagctg 803281 gattaaaaaa ccccctgccg cctggcaggg gttttttcag ctatgccatt ctctcagctt 803341 ctggtcactt ggcaatagga aggcaaggat gccgaggaca gggagaaagg caatggcgat 803401 catcgtcggg gtcagtcccg cggcatcaat cagagcgccc agcgccacag cgccgattgc 803461 gcccatcccg aaggcaagcc cgacggttaa accggacatt gtgccgattt ttccaggaac 803521 tagctcctgt gcgtagacga ccgttacaga aaagctcgac atcagaacca agccaatcaa 803581 tgcgagcacg ccgtaggcga gaaccgggcc ggcaaatggc agcacaatcg ccagcggcgc 803641 cgagcataac agcgaaccga ggataacgaa gcgttttcca aaacggtctg caagcgggcc 803701 gccgagaaac gtgccgatcg cgccgaacag caagaagaca aaaatatagc tttgtgcctg 803761 ctgaatgctt acgtgatagg tatccatcgc gtaaaacgtg taaaagttac cgatcgcact 803821 cgtataccaa gaacgagcaa aaatgagaaa tataataata ataagagcag atacaacaga 803881 tttggtgatg gccgtgtttt cagccgtttt cttttgcttg cctgatttct gggcaaggct 803941 gccgagacgt gaggcgtacc atttcgcaat atacatgaga aacataacag caagcgcggc 804001 gacaagcgtg aaccaaacag cgccgaattg cccgagcggc acaaggatca gcgcggtgat 804061 cagcggtgcc atcgcctggc ctgagtttcc gcccacctga taaatcgatt gggcgagccc 804121 gcgttttgtg ccggcggcca tatacgccac acgggagccc tccggatgga aaatggccga 804181 gcctaatcca atgaaaaaca cacagcataa gatcgttatg aatgacgggg caaatgcaag 804241 gcccaaaatg ccaagcatgc tggcggtcaa accgactggc agcgcatacg gccgcggccg 804301 tttatcggta taccagccga caacaggctg catgacggat gacaccatgt ttaatgtgaa 804361 agcaatgatg ccgagctgtg taaacgtcag gctcatggag cgttccaaaa tagggaacat 804421 ggccggaatc acagcctgaa gcgaatcgtt gagcatatgg caaattccga taataatcaa 804481 aatcggatac accgtggtgc ctggtttttg aactgttttt tcttttaacg gggcggcgat 804541 agccattgag tctcctcctt acatatataa ccaaagcata ccaccatatt attcataagg 804601 tgaagaattt atcaagagga aaaaagattc ttatgaaaga aataccgtca gcctgattag 804661 cagctgacgg tattttcgat attcaaaatg tgatatagct cttcaagctt acgaatctca 804721 taggttggta tgatctctgg cacattcggc ttcatgtcag ggttcatcca gcaagtatca 804781 agcccggcga gctgtccgcc tttgatatca gcagttagtg aatccccgat gattaatgtg 804841 tgctctgctg aaaattgagg aatccgttca aacacgtaat tgaaatattc cttcatcggc 804901 ttttggaagc cggtgtcttc agaaacgaaa atgtccttga agaatggaaa taatcctgaa 804961 tcacggagac gcttatattg tgtgtgagac acgccgtttg tcacgatgta caaatcaaac 805021 tgttgctgca gatttgagat gagatcaaat gcaccgtcaa taagctgatg tccttcttca 805081 agaaagcggc ggtatttttg ctcaagcaaa gcgccgtccg cttcgtaacc gtactccttg 805141 agcaaagcgg aaaaacgtgt gtttacgact tcatcccgtg tcatcttacc ttcttcaaag 805201 gctctccaga gaccttgatt gatggtttta tactgcgcct tcatgtcatt tgttaaagga 805261 atgttctgat cttcaaacag caaacgcagg gctaaagctt ctgccgcttg aaaatcaagg 805321 atggtatcat ctacatcaaa taataaagtg cggtatcgct tcatctgtgt gtctcccttt 805381 ctcatatgta ttcaaagtat agcacataaa aaaaggaaaa agccggcggg tgaggcaccg 805441 ccggctgaaa agagattatt tgtttaataa gctgtgtttt ctcgaatata ggaagtaaac 805501 cagcgttccg acagcgatcc agatgacaaa tgaaagccat gtgacgccgg gaaggctgta 805561 catgaaccaa aggcagatgc ctgcgctgat aatcggcaca accggaacga atggcactct 805621 gaaggacgct ttgatttcag gatgtttctt tcttaacaca atgacagcaa tggaaatgac 805681 cgtaaacgcg gcaagtgttc ccatgttcac cagatgggcc agcgttccga ggttaataaa 805741 gccggcgatt cccgctgcaa cgatccctgt cagccatgtg ttgcggaacg gggttttaaa 805801 tgacggatga acctttgcga acaatccagg cagaaggccg tctctgctca tggcaaatgt 805861 caagcggacc tgtgcgtaca gcaaagcgag catcaccgtc gtaatcccga taatcgcacc 805921 gacagaaata attccggcaa cagcgtcctg tccgacgaat ttcagcgcaa aggatacagg 805981 atctccgaca ttcaatttgg cataaggcat catgcctgtc agcacaagcg ataccgcgat 806041 gtacagaacc gtacagacgg ctagagctga aataatgccg acgggcatgt ttttttgcgg 806101 atttttcact tcctctgatg cgttagaaac cgcgtcaaac ccaaggtacg cgaagaatac 806161 agtggcagcg ctaagtatga cgcctttcat cccgaatggc ataaaaggag accagttatc 806221 cggtttcaca tagccgatgc cgacaataat gaacaataat atgatcgcga ttttcatcag 806281 tacgatgacg ttgttaaagc gtgtgctttc cttgacgcct ctgctgacaa tcgcagtgat 806341 gaggagaatg atcaccgcag ccggaaggtt aaatacggcg cccgccatgc ttcccggcgc 806401 tcctgtcagt gcagccggaa tatgaagatt gaagccggca agcagtgatt gaaagtatga 806461 agaccagccg gtggcaaccg ccgacagtgc aatgacatat tcaagcatga gatcccatcc 806521 gatcaaaaag gcgagcagct ctccaagtgt cacgtatgag tatgagtaca cgcttcccga 806581 aatcggaatg gaagacgaaa actcagcata acagaaagca gccagcgcac aggcgagccc 806641 cgctaaaata aacgatatga tgagggcggg acctgcaccg gtcgctgcca ctgttcctgt 806701 aatgacaaaa atccctgtac cgatgacaca accgataccg agcaaggtta aatcaaatgc 806761 gcttaacgta cgggcaaggc tttttgactt gctctgcgca ctcaatgttt caagcggttt 806821 ttttctaaat aatgaactca tcaaaagttc ctcctagaaa tattcaaaat attctaatca 806881 ttatatgcag ttcttgttgt attatattgt cgaaatttga cgtagtcaat aaaatatttt 806941 tctgctttaa atgatagaag cgaaacagcg ttgtcgtatc ataggatagt aatttttact 807001 aatcgtatat tcaattttat gcaagatgaa ccgatagaaa aaatagattc gcccatattt 807061 tgatttgcgg ttataaagga gatgctgacc atgtttcaat atgaagagtt gaataaacag 807121 tttatcggcg ggaaatggca ggagggcagc agcccaaatg tattggaaaa caaaaatcct 807181 tatactcaaa aaacattcac aacattccgt aaagcgactg ctgacgatgt agatgaagcg 807241 tatcgggcag cggcgctggc aaagaaaaaa tgggatgcgg tcaacccgtt cgagaaaaga 807301 accattttag aaaaagccgt cacgtatatt gaagaaaatg aagaagccat tatttatttg 807361 attatggagg agctaggcgg tacaaggctc aaagcagctt ttgaaatcgg tcttgtcaaa 807421 aacatcataa aagaagcggc aacgttccca atccgcatgg aggggaaaat tcttccgtca 807481 acaatagatg gcaaggaaaa cagattatat cgcgtgccgg caggcgttgt cggtgtcatc 807541 agtccgttta acttcccatt ctttttatct atgaaatcag tggcgcctgc actcggagcc 807601 ggcaatggcg ttgtgctaaa gccgcatgag gaaacgccga tttgcggcgg aacgctgatt 807661 gcgaaaattt ttgagaacgc gggaattcca gcggggctgc tgaatgttgt tgtcacagac 807721 attgctgaaa tcggcgacag cttcgttgag catccagtgc cgcggatcat ctcatttacc 807781 ggttctacga aagtcggcag ctacatcgga cagcttgcga tgaagcattt taaaaagccg 807841 cttcttgagc ttggcgggaa cagcgccttc atcgtacttg aggatgcaga tatagaatat 807901 gcggtcaatg cggcggtgtt cagccgattt acacatcaag ggcagatttg catgtcagcc 807961 aaccgcgtgc ttgttcattc ttctatttat gacaagttcc ttgagctgta ccaggcaaaa 808021 gtggaatcgc tgaaagtcgg cgacccaatg gaccctgata cgattatcgg gccattaatc 808081 aacagcagac agacggacgg gctgatgaag actgtagagc aagcaattga agaaggcgct 808141 gtaccagtga agcttggcgg atttaacggg acgatcgtgg aaccgacgat cttaaaagac 808201 gtcaaaccgt tcatgagcat tgccaaggaa gagctgttcg gaccagtcgt ctcctttatg 808261 aagtttgatt cagaagacga agcggtggat atcgcaaacg aaaccccgtt tggcttgagc 808321 ggtgccgtac atacgtcaaa tcttgagcgc ggcgtggctt ttgcgaaacg cattgaaaca 808381 ggcatgattc acgtcaatga cacgaccatc aatgatgaac cgaatgtagc cttcggcggt 808441 gaaaagcaat caggcctcgg ccgtttaaac ggtgagtgga gcctcgaaga atttacaacg 808501 ctgaaatgga tctcggtcca gcacgaaaaa cgcagcttcc cttattaatg aaaaggagtg 808561 aatggaattg accataaata cggaaaaaga aaccgcagat attctggacg catttatcaa 808621 agtagcccct tatttaaaca gcctggttca ggatgatatt acaatcggca tttatgatac 808681 ggaaaaactg ctcgtgaata taccggccaa aaccttttcg ctgaacgtaa aagccggcga 808741 tccgctgcag gaaggggata tcatcacaga tgccatccgc agcaatcaga agaagacgag 808801 catggttccg aaagaattgt tcggcttccc attgatcgcg cgtgccatcc cgctgcacga 808861 cgagaatgga agagtcattg gaggcgtcgg cctcggaacg agccttgagg agtcgtcaaa 808921 gctgcatgat gtcgcggaaa gcttatcagc tgttgttgaa caaacagccg cggctatttc 808981 cgacatttct gaatcaatta acgggttttc aactcaaatg tcgggcattt cctctcaggc 809041 gaaaaaagta agcgaaagcg ccggtgaaat cgccgatatt tcagtaactg ttaaaggcat 809101 ctcggaccaa agcaatctgc tcggcttgaa cgccgcgatc gaagcggcaa gagcagggga 809161 gtccggaaaa ggattctctg tcgtcgcaga tgagatcaga aagctagcga cgcattcaaa 809221 agaaaatgtc ggccaaattg accagattac gaaaaaaatc cacagcctgc tgaaagggct 809281 ggaggaatcc attgagtcga ttaaccagca tacagacgga caagccgctg ctgttgaaca 809341 aatttccgcc acgatgcagg agatttcagg aagcgcgcag catcttgcga aaatggccga 809401 aaaagcgctt gaggaagagt aagagaccgg ggacaaacat ccccggtctt tttcttatcc 809461 tgcatttcca tgaaattcgt ctgacgtttt actagtttta ttccagcggc tgatttaaaa 809521 tgtacacatg aacttacgtg aggattgata ggaaccatga gcatattaaa agcggaaaat 809581 ctttataaaa catacggaga taaaacatta tttgaccata tctcctttca tattgaagag 809641 aatgagagaa tcggattaat cgggccgaac ggaacaggaa aatcaacgct gttgaaagtg 809701 attgccggct tggaatctat cgaagaagga gaaatcacga aatccggaag cgtgcaggtc 809761 gaatttcttc atcaagaccc ggagctgcct gcggggcaaa cagtgctgga gcatatctat 809821 tccggtgaat cggctgtgat gaaaaccttg cgtgaatatg aaaaagcgct gtatgaactg 809881 gggaaagatc ccgaaaatga acagcgccag aaacacctgc tggcagcaca agcgaaaatg 809941 gacgcgaaca atgcatggga tgcaaacacc ttggcaaaaa ccgtattgtc taagctgggc 810001 gtcaacgacg taacaaaacc ggtcaatgag ctctcaggcg gccagaaaaa acgggtggcc 810061 attgccaaaa acttaattca gcccgctgat ttgctcattt tggacgagcc gacaaaccat 810121 ttggataatg aaacgattga gtggcttgaa gggtatttaa gccaatatcc cggcgccgtc 810181 atgctggtga cgcacgatag atatttctta aaccgtgtca ccaaccgcat ttatgagctt 810241 gaaagaggca gcctctacac ttacaaaggc aactatgaag tgtttttaga aaaacgcgcg 810301 gaacgggaag cgcaggctga gcaaaaggaa acgaagcggc aaaacctgct gcgccgcgaa 810361 ctggcttggc tcagacgagg agcgaaagcc cgctccacaa aacaaaaagc gagaattgac 810421 cgggtagaga cgcttaaaga gcagacaggc cctcagtcat caggttcact cgattttgcc 810481 attggctcgc accgtctcgg aaaacaggtt attgaagcgg agaacgtcat gatcgcttat 810541 gacggccgca tgctcgtcga ccgttttaat gaacttgtca taccaggtga acggatcggg 810601 atcatcgggc cgaacggcat cgggaaaaca acgctgttaa atgcccttgc cggccgtcat 810661 acgccggacg gaggcgatat tacgatcgga cagacggtca gaatcggcta ctatactcag 810721 gatcatagtg aaatgaacgg tgagttaaaa gtcattgact atataaaaga aacggcggag 810781 gtcgtaaaaa cggcagatgg cgatatgatt acagctgaac aaatgctcga gcgtttcctc 810841 ttcccgcgtt cgatgcagca gacgtatatc cgcaagctgt ccggcgggga aaaacgccgt 810901 ttatacttgc ttcaggttct catgcaggag ccgaatgtcc tgtttctcga tgagccgacg 810961 aacgatttgg atactgaaac attaagcgtt cttgaggatt atattgacca gttcccaggc 811021 gtcgtcatca ccgtatccca tgaccgctat ttccttgacc gcgtcgtcga ccgtttgatt 811081 gtatttgaag gaaatggtgt catttcccgc tttcaaggct cctatagcga ctatatggag 811141 gagtcaaaag cgaaaaaagc ggccccaaaa ccggcagctg aggaaaaaac ggctgaagcc 811201 gagccgaaga aaaaacggaa aaagctttct tacaaagacc agttggaatg ggacggcatc 811261 gaagataaaa ttgcccagct ggaagaaaag catgaacagc ttgaagctga catcgccgca 811321 gcaggcagtg attttggcaa aatccaagag ctgatggccg agcaggcgaa aacggcggaa 811381 gagcttgagg ctgcgatgga ccgctggaca gaattgtccc tcatgatcga agaactggaa 811441 agctaaaaag cgtggccgca gcaggccgcg ctttttttca cataatggac aaaaacgaac 811501 cggcctgctt atgttaggat aaagttgtgt gtcagcggca catggaaaac taacggagat 811561 gatgaagtat gacatgggcg atcgtgatgt taattctcat gagtctggtg aaaatcgtat 811621 taacctgtct tcctacaggc gtcatagaat ggctgctcgg caaatttgaa gtgcacgcca 811681 agctgagtga cgaaaatgcg agtctctctc tagatggaaa acgcctcgag ggtgcagaga 811741 agcagaaagt gattgatcaa tttaacgaag ctatcttcct ggaaaaatat tatatctatc 811801 caggtgatga agagcgttat ttacatccgg aaaacggcgg cacgcctctg gtgatagata 811861 caaaaaaagg aaaaaaagac gtgaagctgt tcgtgtaccg ctacgacgac catatcgacg 811921 tcgtgaaaca gtacaagaag aaagtgatcg cgtatcgagt gctttctgaa agccttcaaa 811981 aagagtctct gtcagtggcg ggaagtttag cttaaacagg aaagtgaaag acgggtgctg 812041 tatgctgctc gtctttttta ttgtttttta aaacttaacg tttacgttaa ggttcaaaag 812101 gtgtataatg gtaacagaaa cggcgaaggg ggatttacct tggaatggat gaagattgat 812161 caagtggcca aaagaagcgg gctgacaaag cggaccatcc ggttttatga agaaatcggc 812221 ttgattccgg cgccgaaacg gacagacggc ggtgtaaggc tttattcaga ggatgatatg 812281 gaggagcttg agaaagtcat cagcacaaaa gaggtgctcg gtttttccct tcaggagctt 812341 cagcatttca tggaaaccag ccgccagcta gagttaaaca aagaggggta tttgttgtca 812401 ctggatccta aggaacggaa agaaaaactg gaggaaattc aggaaaccct gaatcaccag 812461 ctggatttga ttgatgagaa aatccgcaca ttccaaagct ttaaagaacg cctgcagggc 812521 atgaaaggca aagcggaacg cgccattcaa tcaatcgaat gaaaagtttg ttaaacgcta 812581 tttttgtagc gtttctttta atggaataaa gatggaggtt aggtcaaatg gataagacaa 812641 cacaagtgaa tcagaaaacg ggtttgctca gccagccaaa agcggtatgg gctgtcgcgt 812701 ttgcctgtgt gatttctttt atgggaatcg ggctggtcga tccaattctt ccggccattg 812761 ccgcacaatt gcatgcttca cctagtgaag tatcactctt gtttacaagt tatttgcttg 812821 taaccggatt tatgatgttt ttctcaggag ccatttccag ccgcatcggc gcgaaatgga 812881 cattaattct cggacttatt tttattattg tgtttgcggg gcttggcggc agctcaagct 812941 caatcgctca gttagtcggc tatcgcggcg gctggggatt agggaatgct ttgtttattt 813001 caacagcgct tgcggtcatc gttggcgtgt cagtcggcgg cagcgcccaa gcgattattt 813061 tgtatgaggc cgcgctcggt ctcgggattt ctgtcgggcc gcttgcaggc ggagagctcg 813121 gaagcatttc atggcgcgca ccgttttttg gagtatctgt cctgatgttt attgcgttaa 813181 tcgcgatttc tttcatgctt ccgaagctgc cgaaaccggc gaaacgcgtc ggtgtgtttg 813241 atgcgatgaa ggcactcaaa tataaaggcc tgctgacaat ggcggtatcg gcattcctat 813301 acaactttgg attttttatt ttgctagctt attctccgtt cgtactggat ttagatgaac 813361 acggtcttgg atatgtcttc ttcggctggg gccttctgct ggcgattacg tcagtcttta 813421 cggcgccgct cgtgcacaaa gcgctgggca cagtgcgttc gctagtcgtt ctctttatcg 813481 cctttgcggc cattctcgtt attatgggga tctggacaga ccatcagact ttgattatta 813541 catgtatcgt tgtcgctggt gctgtcctcg gtatggtgaa tacgatcatg acaaccgctg 813601 tgatgggttc tgcgccggtt gaacgttcaa tcgcgtcttc agcctacagc tcagtccgct 813661 tcatcggcgg cgcgctcgcc ccgtggattg caggaatgct gtcagaacac tttactgcaa 813721 gcacaccata tacagtaggc ggaatcgtcg tttttgtcgg catgcttgtc cttctcatgg 813781 gacgtaaaca tcttgctgga attaaggcgg ggcattaata acgaaagaca ctgcgcatat 813841 gcagtgtctt tttattcgtt ataatgcatc ataatcgaat tggtgcagga aaggacaacc 813901 tttatgacac aattttacta ttttccggct gaaaactccc tttagaaacc ggttttttcg 813961 gtcagcaaga acggcgttcg cggaaagggc atccgcttcg gtcaggcatt gatgcggctg 814021 ggatttatct tgcagaagct gagaatgtgt ccgttcattt acgattgcca tttcagtgat 814081 ggttcatgct gtagagggga cgtttgccat ggataaggca aaacctgacg aatatgatca 814141 gaaatgttta gaaacgctct atcaatacat acacagcgtc atgaaaaaca gcttttctcg 814201 gtcgagtggt ttaccgcttg ggaagatgag gaggattttg agctgtctgc caaaagagag 814261 ctgacacttg atgaattcac atctccattg cagctcattt taaaagacag agagcttttg 814321 agaatcgttc agaaaaaatg gcagtaaaaa acccgccctt tagcaggcgg gtttttttat 814381 aaattaaagc actttcgtcg tccaagactc gcagttccac gtttctgtcg caatatccat 814441 ataaaagtct ggctcgtggg aaatgagcag aatggagcct ttatattctt tcagggcgcg 814501 cttgagctct tccttggcat cggcatccaa gtggtttgtc ggctcatcga gcaccagcag 814561 gtttgtttct gagttgatta gcttgcacaa tctgactttc gctttttcgc ctccgcttaa 814621 tacggagacg cggctttcga tatgctttgt cgtcagcccg cattttgcca gagcggcacg 814681 gatttcatac tgcgtataag aagggaattc gctccatact tcttcgatgc acgtattgtt 814741 gtttgtttcc ttgacctctt gctcgaaata gccggtatag atgtgctcac cgcgttcaac 814801 agagccttcg agcggctgga tttcaccaag caaacttttc agcaatgtcg tttttccgat 814861 cccattcgcg ccgtaaaggg cgattttttg gccgcgctcc atgcggaggt tgagcggacg 814921 ggacagcggg gaatcgtaac cgatcacgag atccttcgtt tcaaaaatca gcttgcctga 814981 cgttctcgcc ggcttaaagt ggaattccgg ctttggcttt tctgccgcaa gctcgatcat 815041 atccatctta tcgagtttct tttggcggga catcgccatg tttctcgtgc tgacacgcgc 815101 tttgttgcgg gcgacgaaat ccttcagctc cgcgacttcc tgctgctgct ttttgtaggc 815161 cgcttcaagc tgctgttttt tcacctcgta gacttccata aactgatggt agtcgccgac 815221 ataacgtgtc agctcttgat tttcaacgtg ataaatcagg ttgatgacac tattcaagaa 815281 cggaatatcg tgggaaatca ggatgaacgc gttctcgtat tcctgcaggt agcgtttcag 815341 ccattcaata tgctgttcat caagatagtt ggtcggctca tcgagaagca gaatttccgg 815401 cttttcaagg agaagcttag cgagaaggac ctttgtgcgc tgtccgccgc tcaaatcggt 815461 gacatctcgc tctaaaccga tatcgctcaa accgagaccg cgggcgattt cttccacctt 815521 ggaatcaatg acataaaaat cattgtttgt cagcgcgtct tgaatgacgc cgacttcttc 815581 aagcagcttc tcgagctcgt cgggatcagc ctcgcccatt ttgttgtaaa tctcgttcat 815641 ttcctcttcc atcgcaaata aataatggaa tgcgtctttc aggacgtcgc gaatggattt 815701 tcctttttcc agcacggtat gctgatcaag gtatccgaca cggacatttt ttgaccattc 815761 gacttttccc tcatcaggtt caagctttcc ggtaataata ttcatgaagg ttgattttcc 815821 ttcaccgttt gcgccgatca agccgacgtg ctcgcctttt aacaggcgga aggaaacgtt 815881 attaaaaatg gcccggtccc cgaaaccgtg gcttaaatcc tttacagata aaatactcat 815941 gtttacacct ctatcgttat caaacacgca caatcggcgt gtaatattca cccttttgat 816001 tataaaggag gattcggaat gttgaaaggt ataggaaaga aaaagaaaaa ttgcgttccg 816061 ggcgaggttt tgagatacta tggaatagat ttcaggaatt gaggagaaca aaatgacgca 816121 aacttggcca tttttacata atgcacaatc atttatacaa gagaattgga atgcttccgg 816181 ctttcaaaag ccaacccctg ttcaggagca ggcagcccag ctgatcatgg acggaaagga 816241 tgtcattgca gaatcgccga caggcacagg gaagacgctg gcgtatgcgc tgccggtctt 816301 ggagcggatc aaaccagagc aaaagcatcc gcaggcggtg attttagcgc cttcccgtga 816361 gctggtcatg cagatttttc aggtgattca ggattggaaa gcgggctcag agctgcgcgc 816421 ggcttcctta atcggcgggg cgaatgtgaa gaaacaggtc gaaaagctga agaaacatcc 816481 gcatatcatc gtcggcacgc caggcagggt gtttgaactg attaaagcga agaaactcaa 816541 aatgcatgaa gtgaaaacga tcgtgcttga tgaaacggat cagctcgtcc tgccggagca 816601 tcgcgaaacg atgaagcaaa tcattaaaac aacattaaga gaccgccagc ttctatgttt 816661 ttctgccacg ctcaaaaagg aaacagagga cgtgctccgc gaattggcgc aagagcctga 816721 ggtgttgaag gtgcagcgaa gcaaggcgga ggcagggaaa gtgaagcatc aatacctgat 816781 ttgcgaccag cgcgacaaag tgaagctgct gcaaaagctg tcaaggcttg aaggcatgca 816841 ggcactcgta tttgtgagag acattggcaa cctgagtgta tatgcggaaa aactggcata 816901 tcaccacgtt gaactcggcg ttttgcacag tgaagcgaaa aaaatggagc gagcgaaaat 816961 cattgccaca ttcgaagacg gagagtttcc tcttttattg gcgactgaca ttgccgcacg 817021 cggtttagat attgaaaacc tgccatacgt gattcatgct gatattccag atgaagatgg 817081 ctatgtccac agatcaggac gaacaggccg ggccggaaaa gaaggcaacg tgctgagcct 817141 tgtgacaaaa ttggaggaat ctaagctgaa aaaaatggcg aagaagcttg gtgttgagct 817201 gagtgaagct gtgtatgcag gcggaaaact gaagacgaaa taaaaagaag ggcgaagagc 817261 cctttttttg ttgtaaaata atagaaaaga ttttgcgcgg aggtgggaaa atggcttcaa 817321 tagacaggtt tcaagtaatg caggagccag agctgaaaat ccttgaacac tggtttgaga 817381 atgaggatac cagacggaga atggatggga tgctgctatt agatgagtgg tatgcacgag 817441 taaataaaga taaacacgat actgtcatca tggcgtatga tggacagctg ccggcaggga 817501 tggtcgttat tgagttcgga gaggagcgga catatattgg attgatcgtc aatcctttgt 817561 accggcttaa agggtatgga aaacagatac tgcaaaagct gatgaccgaa cctgatttta 817621 ctagcgtgcg agaatgggtg gcatgcattg aagaagacaa tcgaatcagt ttagcttgct 817681 ttcaagcagc aggattcact ttagaagaca cggaacctga tgaagatggt tttcttacgc 817741 tgattcttcg caactgatct catcgaaaca caaaaggagg gcaaaaagcc ctcccgtttt 817801 catcttcatt cagctcggat cactgacctt gatcagctgt ttccctttat tttctccctt 817861 aaataaaccg agaaacgcgt caggaatgtt ttcgaagcct tctgtgatgg tttcctcgta 817921 atggagttta ccagccttca gccattctgc cagctgtttt gctccctcag aaaaacgatc 817981 ggagtagtcg cttacgataa agccttgcat cagcgacttc gttttaatga gttttgattg 818041 gacacgaggg cccatgtcat ctgcttcgct ttctgcgtta taggaagaaa tggcgccgca 818101 caccggaatg cgggcaaatt cattgagcag attcatcacc gcgtctgaaa tcggtccgcc 818161 gacattgtca aaatacacat cgacaccgtc aggacaagcg ttttgaagcg ctttttggat 818221 atcatccgct gttttgtaat tgatggcttc gtcaaactga agctcctgtt ttaaatagtc 818281 gattttttca tcagagcccg cgatgccgac gactcgcgcg cctttgattt tggcaatttg 818341 cccgactgtt gaaccgacgg ctccggcagc tcctgagaca accacggttt cgccttcctt 818401 cgggcgtccg atgtccagca atccgaagta tgctgttaag ccggtcattc ccaaaatgcc 818461 gagataggcc gaagcgggag caaggcttgt atcaattttt cgcaaggcag actcgctcac 818521 agcggaaaat tcctgccagc tgagatttcc gatgacgata tcgccttttt tcagatgatt 818581 cccgtctgac acaacttcag cgataacccc tccagaaagc gctttatcca aggcgaacgg 818641 ctcaacatat gacttcgtat cctgcatacg gccgcgcata taagggtcaa ccgatacata 818701 aagcgttttg acaagcactt ccccttgctt gggttcagga accggaatgg tttcaaagcg 818761 aaagtcttca tgaacaggaa taccttgtgg acgtcttgct aattgaattt gctgctgaga 818821 tgctgtcatt ttcatcctcc tatcacttgg ttgacaccac tgtaacatgg acaggagagg 818881 aaatacaaaa ggtaagctgg catacaaaaa aggttataga tgagcttatg ctttctacaa 818941 gctcttttgt tttaaaagtt ctctttagtc atttatcatt attagaaaac agaacagaaa 819001 aagagctcct gtacacctag ctaagattgg ctagtgtgta tgtcgattct ttttcatatt 819061 cttgcaagca tctgcgaggg ggagcttagt cgttcacatt ttgctttcgc atcaatctgc 819121 aatagcaaag tctatgcgat ttttttacat cagcaaagat ttgttcaatt ttttcctttt 819181 atgccgagtt tttctgaaac agataattga tggtactcaa ccattttctt ttggtcaata 819241 aagtaatgtt tacttattaa ttaaacacgc gaaaaagcaa acgaaaacat aattaaattt 819301 tatatattta ttaaaagctt atatgtttat ttaccttttt tttgaattgt aattgagaaa 819361 atccatatat tgcggacact aataaaagaa tacctgctga aacataaact aaacgaactc 819421 caaggaaatc tgaaatagcc cctatagcca gaattgaaaa cataaaaatg aactgtacta 819481 aagaagacct tgcagacatt atattaattc gagtttgctc ggttgttatg ttctgaataa 819541 gtgtttcttg tgtaagatct cttaatatat aagccggccc cataaagaga accaaaatta 819601 gagctaagta tgaattactt ataaaaccat atattaaagt taaacttcca tatgagacag 819661 cgccaattaa cataaaatta attaacttat tttgaaatct ctccgacagc ttatatatta 819721 taaatccccc tatcatcgaa cctaaataat atgctccatt aataaatccc caccatgatt 819781 ctcctttatg caagacttcg ttaacgaaag ctaaagagac agatcctatc caaatcattc 819841 ctgcccatga ctcaattaaa tccataataa taattgttct aagtttcttt tggctaaata 819901 aataccgcca accacttact atactcttat tgggagaatt tttttcacgt atgacagaat 819961 tagcgtggcc atgtggtaga caaaataaaa gagaaagaag agatgtaaac aacaaaaaga 820021 tagtaagtat aatggtatat ccctcaccta aaaatgcaat tatgagacca cctaaagacc 820081 agcctacaaa ttgaaaagtt tggtccactg tagataataa tccatttgct tttactcttc 820141 tatcaggaga gattatttcc cctataattg cactttttaa aggtgagaac catccattaa 820201 aaaaggaaat acagctaata ataataaaga ctaaaatgag agtttgatta gagtaagttc 820261 ttaataaagc atagaacaaa catattaata acagcatttg tatcaattga gaaataatta 820321 ttgtaagagg cagttttaat cgaattgtta ttaacggtaa tatagcactt ccaaaaatac 820381 gaaaaataat acttattaat gtcaccatag aggcgatggt tgtcgaattg gtcattttaa 820441 acaaaaacga aatcactacc atagtatata gagaaaaacc taaatttgta gtggtctggc 820501 taaataaaat agaataataa cctttactca tatgtatcct cccttggaat aatttttctc 820561 ggtaaagagc ttaaacatat ttaaacacct taaaacaaca aaagtaaaga aaaaatttcc 820621 ttgtaaacta tttactttta ttctatttat tgttattgtt tatttaagtt ctctgactat 820681 tctatcaata ttcagggaac cacatatctt attaaagggg ggaaaaccat gagaaaatta 820741 agaaaaaact ggagaaaatc gattgttagc ccggttcttt atactaatga aaaatggtaa 820801 acacttaggg aatagcattt aatgctattc cttatttcaa caaacaaatc gggaggttat 820861 cgtaatttga ctctattaat gcaagatcat aaatcaattt acaataaaga tatagaaata 820921 ttaattgaag ttgaagaact tattacttct gttccagaaa ataaaaaaaa tgattttaag 820981 agtttaatcg ataatagaat tatgactcta ctaaataaaa ttcaacaccc tgtagcagcg 821041 gaaaatgtgt ttgggatgtg tattgcttat ccgaatactt acataaggta tagattaatt 821101 gatttcgttg aaaaatgggt accttatttc tctgctgtag aaactataat caatctaacc 821161 caggatccgg atgatttagt ttcttttaaa gctatggatg tctgtgcaaa tcataaaatt 821221 gaagaatctg tagcatattt gtcttcgatt attgatgatg tccgggagag tataagctac 821281 cctaaaaaac ctgtgggatt aggggcccaa aaagtattaa gtacattatt agatatattc 821341 ggtgttgaaa aacatgaaga gctagtaatg ctaaaaaatt attttgatca aaatggtata 821401 cttcctaata actttgactt tgaagaaaaa attcctcaaa gtctaataga ggaattcgaa 821461 aaaacagaag aagatgggat gattttaatt ccgggtggct tttttgaatt cggtttaaat 821521 gaaaatgaaa ttcctgacaa aacatttaat tggaaagatg ctgttcctag acaaaaagta 821581 tggttacctc cattttttat cgataagtat cctgttacaa ataaagatta tgatatcttt 821641 accgagttca tagaggaaaa tgggcatata ttctgtcatc ctaatgaacc gcagaataaa 821701 caacatagaa gaaatacata ttgggatgat aggtatttag ataatcatcc cgttacaggt 821761 atagattttt atgatgcatt tgcttacgca agatataagg ggaaagaatt gccaaccgag 821821 tttcaatggg aaaaagctgc tcgaggcgaa aagggtaatg tctggccttg gggagataaa 821881 tttgatcctg caaaggttca atatgctgga agtctttata atgaacccat tacttcttta 821941 aagtcctgga gagaaaattt attaaaagct catgctgata aagaattaaa tcatttaaca 822001 agtgatattt ttgaacaaaa tggtgaaagt ccctatggag tatgcggtat gatcggcgga 822061 acatgggagt ggactagaag tgagcttaaa acaaagagag ctttccaccc tatttttgag 822121 aatgtaccat ttaatagtgt taactcattt gccgttctta aaggaggatc attcttctct 822181 catccaggct taatgttccc ttcttttaga gcaaaagata ttcctttctg tcgacacaat 822241 gaaatgggga ttagatgcgt aaagaatatt ccagtatata aaattagaga atcaattaat 822301 gggccaatta ctaataaagc aatttattaa tcattctagg ttagagactt gataaaagta 822361 tactaacatt gtgtagtaat gttcagcttg tagaaaaaac aatgtttttt ctacaagatt 822421 ttattttaaa tgcttttcaa aattatcagg gattgagaat cagaaaaaga gccattaagc 822481 tcgatcttag ctaggtatta cgatcttctg tatattattg tgagaaatat agaagattca 822541 gttagttagc atttcgattt taagctgagc ctgcaatagc aaagcatctg ttttgattat 822601 tctttttctg atacataagc taattttgtc gcttttcttt tttgtctttt cacgcatttc 822661 gaggatgact tactataatt ctttcagctt ttctatgtgt taagattcga atagatgaaa 822721 taactttaac aagttggtca ataagaacag atttaacttt atgttaaaag agtatctcgt 822781 atagaacata agaagaatga cgagtttttt aagattatca tcaattatgt gagaataaaa 822841 tattataagg gaaaatgaag gctgtcacgt ttctcgacag ccctagggaa ttcctctcct 822901 tttcatttcg cccgtaattt cgggcacagt cccgtcggca ggcacattgg cttctggtcg 822961 atcgggcttc tcatgatgca gcattccaag ccgaagactt cacggaaaaa tggctgggtg 823021 aacacatctt ccggtgttcc ggcgttgtat atttttccgt ccagcacact gatcagatag 823081 tcagcatatt gagcggcttg gtttaaatca tggagcacca tgacaacggt gcggccatgg 823141 tcgcggttca gctttttcag cagttcaagc acttcaatct gatgtgagat gtctaaatac 823201 gtggtcggct catcaagcaa aagcaaatca gtgccttgcg caagtgccat ggaaatccag 823261 gctctttgtc tttggccgcc tgagagggca tcaagtgtcc gatccttcag ttcaatcatg 823321 cccgttgctt ccagcgccca ctctaccatg tcatgatcct cttgggtatg cttggataac 823381 agctttttgt gaggatgtct gccaaaatag cataattcct ctaccgtcaa tccttcagga 823441 gcctgaggag attgtggaag aatggccagt ttttttgcga cttcttttga tggctggcgg 823501 tggatgtctt ttccttctag tagcactgta ccgctttttg gggccatcag cctggcgagc 823561 gatttgagga ttgttgattt accgcagcca ttagcgccga tgagcgcagt gatttttcct 823621 tcttctatct ttaagtcgac tccgtcaata atcactgtac tgtcatatga aagagtgagc 823681 tggtctgcag ccagttttcc catggtatcc tctccctact gtttcctcgc ttcgaatttc 823741 aataaatata agaaataagg cgcgccgatc acggctgtca gtattccggc aggtatttca 823801 accggaggca tgatgccgcg ccctaacgta tctgcaatta ataatataat agcaccaatc 823861 aatgccgatg caggcagtaa atatttagct ttttctccgg taagccgtct ggcgatatgc 823921 ggagcaagca agccgataaa accgattgag ccgacgacgg ctacacagct tcccgccagc 823981 gccaccgcgg tgaaaatcag gatgaatctc agccggtttg cgttttctcc gagaccctgt 824041 gcaagctcat ccccgagtga cataagatcc agcttcggta tgagtatgca gacgatcgga 824101 aaaagaatca aaagccatgg cgcaagcagc ttgacttctt cccagtttct tccccagagg 824161 cttcctgtca gccaaatgag tgcagcattc acgtcgcctg gaaacttgac catcatatat 824221 tgcattccgg cgtggcagac cgcgcctaaa gcaatgcctg ataaagccag tgaagagggc 824281 tgaatgctct tttttcgggc tatcattaat aatagtacag caataatggc ggctccggca 824341 aatgcggaga acggaagcac gtataccggc gactcaggaa agatgagaat cacagccatc 824401 gccgcaagtc cggagccttt tgaaatgccg acaacgtccg gggaagcgag cggatttcgg 824461 atcacaccct gtaaaatcgc tccggcagcg gcaagtccag cacctgccaa aatcgctaat 824521 ataatgcggg gaaggcgata ttgctggatg ataaattcaa aggaatgatc cagtcccagc 824581 agattcgtca ctaccgcatc aggtgaaatg tataatgcac cgattccaat gctgatgacg 824641 gacagaacga ttaaaatcac ggccaatatg agtatcgcca gtaaggggcg tttttgtttt 824701 ctggttgttt tcttcatttc aggtttcgcc ctttccttgc caaatataag aaaaacggcg 824761 ttccgataat cgcggtgaca atgccgaccg gtgattcata aggaaatgca atccatctgg 824821 ccagaacatc tgcgtacacc agcaaaatgg caccgaacag tgccgaaaac ggaagcacgt 824881 attgataatg ttctccgatc agcttgcgga caatatgcgg gacgagcagc ccgacaaagc 824941 caatcggccc ggcgacggct acggaagcgc cggaaagaat taaaataatc aaactgatca 825001 gaatcctgat gccgttcata ttttgtccaa gcccttttgc tgtttcgtct ccgagaccga 825061 gaacagaaac agaaccggaa aatacgaggg caagcccgat gccaatgaca gaaaaaggag 825121 cgatggttat gacgtcctgc cagttgctgc cgtcgattgc gcctgtcatc cagtacagaa 825181 catcctcacc tgactcattt aaaataatga tggcctgtgt catagaggag aggaacaagt 825241 gcacggccat tcctgacagc gccagcttga caggcgtcat tccgccggat gaggcaatca 825301 tatacacaat cgcgccgcct gctgccgcac ccgcaaaagc gaatataaca gatgaatagg 825361 gcgatgccgg cagaatgacg agagaagcaa caacaaaaag cgatgcaccc gcattcacac 825421 cgaaaatttg gggtgaagcc agaggatttc tggtcatagc ctgcatcagc gcccctgcta 825481 cagctaggct ggcgccgaca aaaacgccga ttaatgtgcg gggaaggcga agagtagaga 825541 tgatgagctg ttcctttgaa ccgtcccata caaaaagata tttcaatgaa tctatgatgc 825601 tgatgtctga ggctcctact gaaagattca gcccaagccc aaatataaaa ataatcagtg 825661 caatgataaa catcatcagt cttgatgatg agcgccgttt ggctgaatga tacaacagtc 825721 tcacttcctt actgcgtctg gttgcaaaaa cgaagaagca aggattcccc tcgcttctca 825781 tttgtcctat ttattataca cttttttaag cacatctttg gcgcttgttt cactagactt 825841 gatgcctctg aatcttgtcc aagtgtcacg gtccgcatca tagacttgtc catttttcac 825901 cgctttgaga tttttccaga gcgggttcgt tttccactca tctacaatgg ttttgccttc 825961 gttggctgag atgaacaaaa tatcaggatc gattttgctc aattgctcaa ggctgacctc 826021 ttgataggcg ttatctgact tcacagcgtg tgtaaagcct agcattttaa agatttctcc 826081 gtcataggat gatgatgtat gaagctggaa ggaatccgct cttgcaacgc cgagaacgat 826141 gttgcggttt tcatctttcg gaagttcggc ttttagatcg ttgatgactt ttttgtgctc 826201 ggcaagcttt tcttttcctt catcttcttt atttaatgct ttagcaatgg tcgtaaagct 826261 gtcgatcgtt tcgtcatatg tcgcttcacg gctttttaat tcaatcgtcg gggcgatttt 826321 tttcagctgt ttataaatgt ttttatggcg ctcagcgtca gcgatgatta aatcaggctt 826381 caaggaactg atgacctcaa gattgggttc gctgcgtgtg cctacagatg tgtaatcaat 826441 ggagctgccg acaagctttt taatcatatc ttttttgttg tcatctgcga tgcccaccgg 826501 cgtaatgccg agattgtgaa cggcatccaa gaatgaaagc tcaagcacaa ccacccgctt 826561 aggtgtgccg cttactgtcg tttttccttc ttcgtcatgg atcactctgg aatccttaga 826621 ctcgcttttg ccgcttccgt tgttattctg gcttgatgaa cagccggata caatgaggca 826681 ggcgagcaat aaaacactca tgatggcaat caacttgtta gaataggtgc gcatgtcatt 826741 cttccttttt tcagatttag taatgagaat cattatcaca tgtaacacta taatagcatg 826801 gcttatcatg tcaatatttt tttagtaaag aaagctgcgt ttttactgct ttctcatgaa 826861 agcatcatca gacacaaata agtggtatgc agcgttaccg tgtcttcgag acaaaaacgc 826921 atgggcgttg gctttagagg tttcgaacat atcagcagtg acataaggaa ggagagtgct 826981 gagataaccg gacaatttct tttctatttc atctgttagt gcaaattcaa tgtcgccgat 827041 attcatgata atcgagaaaa caaagtcgat atcgatatga aaatgttcct cggcaaaaac 827101 cgcaagctcg tgaattcctg gtgaacatcc ggcacgctta tggaaaatct gtttgactaa 827161 atcactcaca atccaagcat tgtattgctg ttctggtgaa aagtattgca ttagacatac 827221 ctcctgctcg tacggataaa ggcagcgttt catggtcgtg tgctccgtgc agcggcttct 827281 ccttaatttt gatttttctg aaaataggtc ccgttcctat cactttacca tggacggaaa 827341 acaaatagct actaccattc ctcctgtttt tctcttcaat gttctggaat ctgtttcagg 827401 tacagacgat cgggtatgaa agaaatatag aaaacatgaa ggaggaatat cgacatgaaa 827461 ccagttgtaa aagagtatac aaatgacgaa cagctcatga aagatgtaga ggaattgcag 827521 aaaatgggtg ttgcgaaaga ggatgtatac gtcttagctc acgacgatga cagaacggaa 827581 cgcctggctg acaacacgaa cgccaacacg atcggagcca aagaaacagg tttcaagcac 827641 gcggtgggaa atatcttcaa taaaaaagga gacgagctcc gcaataaaat tcacgaaatc 827701 ggtttttctg aagatgaagc cgctcaattt gaaaaacgct tagatgaagg aaaagtgctt 827761 ctctttgtga cagataacga aaaagtgaaa gcttgggcat aaagcaagga aaaaaccaaa 827821 aggccaatgt cggccttttg gtttttttgc ggtctttgcg gtgggatttt gcagaatgcc 827881 gcaataggat agcggaacat tttcggttct gaatgtccct caatttgcta ttatattttt 827941 gtgataaatt ggaataaaat ctcacaaaat agaaaatggg ggtacatagt ggatgaaaaa 828001 agtgatgtta gctacggctt tgtttttagg attgactcca gctggcgcga acgcagctga 828061 tttaggccac cagacgttgg gatccaatga tggctggggc gcgtactcga ccggcacgac 828121 aggcggatca aaagcatcct cctcaaatgt gtataccgtc agcaacagaa accagcttgt 828181 ctcggcatta gggaaggaaa cgaacacaac gccaaaaatc atttatatca agggaacgat 828241 tgacatgaac gtggatgaca atctgaagcc gcttggccta aatgactata aagatccgga 828301 gtatgatttg gacaaatatt tgaaagccta tgatcctagc acatggggca aaaaagagcc 828361 gtcgggaaca caagaagaag cgagagcacg ctctcagaaa aaccaaaaag cacgggtcat 828421 ggtggatatc cctgcaaaca cgacgatcgt cggttcaggg actaacgcta aagtcgtggg 828481 aggaaacttc caaatcaaga gtgataacgt cattattcgc aacattgaat tccaggatgc 828541 ctatgactat tttccgcaat gggatccgac tgacggaagc tcagggaact ggaactcaca 828601 atacgacaac atcacgataa acggcggcac acacatctgg attgatcact gtacatttaa 828661 tgacggttcg cgtccggaca gcacatcacc gaaatattat ggaagaaaat atcagcacca 828721 tgacggccaa acggatgctt ccaacggtgc taactatatc acgatgtcct acaactatta 828781 tcacgatcat gataaaagct ccattttcgg atcaagtgac agcaaaacct ccgatgacgg 828841 caaattaaaa attacgctgc atcataaccg ctataaaaat attgtccagc gcgcgccgag 828901 agtccgcttc gggcaagtgc acgtatacaa caactattat gaaggaagca caagctcttc 828961 aagttatcct tttagctatg catggggaat cggaaagtca tctaaaatct atgcccaaaa 829021 caatgtcatt gacgtaccgg gactgtcagc tgctaaaacg atcagcgtat tcagcggggg 829081 aacggcttta tatgactccg gcacgttgct gaacggcaca cagatcaacg catcggctgc 829141 aaacgggctg agctcttctg tcggctggac gccgtctctg catggatcga ttgatgcttc 829201 tgctaatgtg aaatcaaatg ttataaatca agcgggtgcg ggtaaattaa attaagaaag 829261 tgaaaaacac aaagggtgct aacctttgtg ttttttaatt aattaaaatg tttattaact 829321 tagttaagga gtagaatgga aaaggggatc ggaaaacaag tatataggag gagacctatt 829381 tatggcttca gaaaaagacg caggaaaaca gtcagcagta aagcttgttc cattgcttat 829441 tactgtcgct gtgggactaa tcatctggtt tattcccgct ccgtccggac ttgaacctaa 829501 agcttggcat ttgtttgcga tttttgtcgc aacaattatc ggctttatct ccaagccctt 829561 gccaatgggt gcaattgcaa tttttgcatt ggcggttact gcactaactg gaacactatc 829621 aattgaggat acattaagcg gattcgggaa taagaccatt tggcttatcg ttatcgcatt 829681 ctttatttcc cggggattta tcaaaaccgg tctcggtgcg agaatttcgt atgtattcgt 829741 tcagaaattc ggaaaaaaaa cccttggact ttcttattca ctgctattca gtgatttaat 829801 actttcacct gctattccaa gtaatacggc gcgtgcagga ggcattatat ttcctattat 829861 cagatcatta tccgaaacat tcggatcaag cccggcaaat ggaacagaga gaaaaatcgg 829921 tgcattctta ttaaaaaccg gttttcaggg gaatctgatc acatctgcta tgttcctgac 829981 agcgatggcg gcgaacccgc tgattgccaa gctggcccat gatgtcgcag gggtggactt 830041 aacatggaca agctgggcaa ttgccgcgat tgtaccggga cttgtaagct taatcatcac 830101 gccgcttgtg atttacaaac tgtatccgcc ggaaatcaaa gaaacaccgg atgcggcgaa 830161 aatcgcaaca gaaaaactga aagaaatggg accgttcaaa aaatcggagc tttccatggt 830221 tatcgtgttt cttttggtgc ttgtgctgtg gatttttggc ggcagcttca acatcgacgc 830281 taccacaacc gcattgatcg gtttggccgt tctcttatta tcacaagttc tgacttggga 830341 tgatatcaag aaagaacagg gcgcttggga tacgctcact tggtttgcgg cgcttgtcat 830401 gctcgccaac ttcttgaatg aattaggcat ggtgtcttgg ttcagtaatg ccatgaaatc 830461 atccgtatca gggttctctt ggattgtggc attcatcatt ttaattgttg tgtattatta 830521 ctctcactat ttctttgcaa gtgcgacagc ccacatcagt gcgatgtatt cagcattttt 830581 ggctgtcgtc gtggcagcgg gcgcaccgcc gcttttagca gcgctgagcc tcgcgttcat 830641 cagcaacctg ttcgggtcaa cgactcacta cggttctgga gcggctccgg tcttcttcgg 830701 agcaggctac atcccgcaag gcaaatggtg gtccatcgga tttatcctgt cgattgttca 830761 tatcatcgta tggcttgtga tcggcggatt atggtggaaa gtactaggaa tatggtagaa 830821 agaaaaaggc agacgcggtc tgcctttttt tattttcact ccttcgtaag aaaatggatt 830881 ttgaaaaatg agaaaattcc ctgtgaaaaa tggtatgatc taggtagaaa ggacggctgg 830941 tgctgtggtg aaaaagcggt tccatttttc cctgcaaaca aaaataatgg ggctgattgc 831001 ggctctgctg gtctttgtca ttggtgtgct gaccattacg ttagccgttc agcatacaca 831061 gggagaacgg agacaggcag agcagctggc ggttcaaacg gcgagaacca tttcctatat 831121 gccgccggtt aaagagctca ttgagagaaa agacggacat gcggctcaga cgcaagaggt 831181 cattgaacaa atgaaagaac agactggtgc gtttgccatt tatgttttga acgaaaaagg 831241 agacattcgc agcgcctctg gaaaaagcgg attaaagaaa ctggagcgca gcagagaaat 831301 tttgtttggc ggttcgcatg tttctgaaac aaaagcggat ggacgaagag tgatcagagg 831361 gagcgcgccg attataaaag aacagaaggg atacagccaa gtgatcggca gcgtgtctgt 831421 tgattttctg caaacggaga cagagcaaag catcaaaaag catttgagaa atttgagtgt 831481 gattgctgtg cttgtactgc tgctcggatt tattggcgcc gccgtgctgg cgaaaagcat 831541 cagaaaggat acgctcgggc ttgaaccgca tgagatcgcg gctctatatc gtgagaggaa 831601 cgcaatgctt ttcgcgattc gagaagggat tattgccacc aatcgtgaag gcgtcgtcac 831661 catgatgaac gtatcggcgg ccgagatgct gaagctgccc gagcctgtga tccatcttcc 831721 tatagatgac gtcatgccgg gagcagggct gatgtctgtg cttgaaaaag gagaaatgct 831781 gccgaaccag gaagtaagcg tcaacgatca agtgtttatt atcaatacga aagtgatgaa 831841 tcaaggcggg caggcgtatg ggattgtcgt cagcttcagg gagaaaacag agctgaagaa 831901 gctgatcgac acattgacag aggttcgcaa atattcagag gatctcaggg cgcagactca 831961 tgaattttca aataagcttt atgcgatttt agggctgctt gagcttgggg agtatgatga 832021 agccattgat ctgattaaag aggaatatgc gatacaaaat gaacagcatg atcttttatt 832081 ccataacatc cattcgcagc aggtgcaggc cattttgtta gggaaaataa gcaaggcatc 832141 ggaaaagaag gtcaagctgg tgattgatga gaacagctca ctcgcgcctc ttcctgcgca 832201 tatcggcttg tcccatctta ttacgattat tggcaattta attgataacg ctttcgaagc 832261 tgtagcggag caaagcgtga aggaagtttt gttttttatc acggatatgg gccatgacat 832321 tgtcattgaa gtatcagaca cagggcccgg tgtgccgcca gagaaaatag aagctgtgtt 832381 tgagagaggc tattcttcaa aggggatgag gagaggctac ggtctggcca atgtgaaaga 832441 ctcagtgcgt gaactgggcg gctggatcga actggcgaat caaaaaactg gcggggcggt 832501 attcactgta tttataccga aggagaaaca aagggggaat ccatttgatt cacatcgcga 832561 ttgcggagga tgattttcga gttgcgcaaa tccatgagag attgattaaa cagcttgatg 832621 gattcaagat tatcggcaag gcggctaacg caaaagagac attggcgctt ttgaaggaac 832681 acaaggctga tttgcttctg ctggatattt atatgccgga cgagcttggg accgcgttga 832741 ttcctgatat acgaagccga tttcctgaag tggacattat gattatcaca gcggcaacag 832801 aaacccgtca tttgcaggaa gcgctaaggg cgggaattgc ccactatttg atcaaacccg 832861 taacagctga caagttcagg caggtgctgc ttcagtataa agaaaaaagg aagctgctca 832921 tgtctcagcc ggaggtcagc caatccatga tcgaccatat ttttgggaac ggtgtgaaga 832981 cagctttgcc ggcagaggat ttgccgactg gcattaattc gattacactg cgaaaaatta 833041 aggaagcgct tcagactgcg tcagaaggat tgacagcgga ggaacttggg gaaaaaatgg 833101 gggcgtcacg aacaactgcc cgccgttatg ccgagtacct tgtgtcaaag gaagaagcaa 833161 gagccgagct tgaatacggg attatcggca ggccggagag aaaatattat ttggcggcgg 833221 attagatatg aaaaaatcta taatcctatt gaatattcta ttgatcttta tgcagggtga 833281 tatcaggcag gcggctgcgc cgcgcctgcc ggacgggccg atagaaattg tcgtccctgc 833341 cgaaccttct ggcggctggg atgtcacagc gcaggcgatc caatcagttt tgaggcagaa 833401 gcagatcgtg aaggatgatg ttcatatcgt ctataaatcc ggcggcgggg gagagaaagg 833461 ctggaaatat gtcaacaaaa gcagcaaaca aaccatcagc atgacgtcca gcctaatatt 833521 gagcaatgat cttctcgggc aaagcaaatt aaaaatgtcc gattttacgc cgctcgccat 833581 tctctccaag gaatggcaga cggttgcatt gccaaaagga tcagcgttaa caaatggcaa 833641 ggatgtgctg aatgagatca acatgcatcc cggcaaggtg agaatcggct ttgccccggg 833701 gtttggcaat gatgatcagc tctcgttcgt cagagcggca gatatgtacg gcattgaccc 833761 gtttgacatt caattctcac agtatgacag cagcgaacag ctcattcagg cgctgatcag 833821 acatgagata gaagcggctt ccatgacact ttctgaagcg aaaccatatg aacgaaacgg 833881 cgatatcacg ttagccgctg taacgtctga taaaagactt cccggttttc caaatgtacc 833941 gacgtggaag gagcagggaa tcccgtttgt tttttctcat tggagaggga ttttgggccc 834001 gaaaaatatg tctgaggaag agatttctta ctgggatcaa gcgctaaaga aggtcacctc 834061 ctcacctgaa tggaagcgga aaataaacga acaggactgg gaaagctttt atttaaacag 834121 cagggaaacg aaacggtttt tagaagagca atctgctttt tatcaaagca tcatgacagg 834181 aaattaaaat cccgacatcc cgggattttt ttcatgccga aaattgatca aaaagaacaa 834241 aacggtttta aaaaattaaa aatacaaaaa aaccaaatta tttacttgcg gttggttttc 834301 ccatacgatg gcaaaaaggc aagacaaaaa ggggagtaag ggagaaaaaa atgtaagcgg 834361 attcatttaa gggggaatgg atgtgttagc aatcttaggc tttctcatga tgcttgtgtt 834421 tatggcattg atcatgacaa aacggctttc tgttttaaca gcattagttt tgacgccgat 834481 tgtgtttgcg cttatcgccg gatttggatt tactgaagtt ggggacatga tgatttcggg 834541 gattcagcaa gtcgcgccga ctgcggtcat gattatgttt gcgatcttat attttggaat 834601 tatgattgat acaggcctgt ttgatccaat ggttggcaaa attttaagca tggtcaaagg 834661 agacccttta aaaattgttg tcgggacagc ggttcttaca atgctcgtcg ccttggacgg 834721 agatggctcg acaacgtaca tgattacgac aagcgccatg cttccgctct atttgctgct 834781 aggcatccgg ccaattatct tggcaggaat cgcgggagtc ggcatgggaa tcatgaacac 834841 gattccatgg ggaggtgcga cgccgagggc ggcgagtgcg ctgggggttg atccagctga 834901 gcttacaggg ccgatgattc ctgtcattgc aagcgggatg ctttgtatgg tggcagttgc 834961 gtatgtgctt ggaaaagcgg aacgaaagcg ccttggtgtg attgaactga aacagccagc 835021 caatgccaat gaaccggctg ctgcggttga agatgagtgg aagcggccga agctttggtg 835081 gttcaattta ttgttaacgc tttctttaat aggatgttta gtatcgggta aagtcagttt 835141 aaccgtactg tttgtcattg cgttttgtat tgcgctgatt gtgaattatc ccaatctcga 835201 gcatcagaga cagcgcatcg cggcgcattc cagcaacgtg ctggctatcg gttcaatgat 835261 ttttgctgcg ggggtgttca cggggatttt gacaggcacg aaaatggttg atgaaatggc 835321 gatctcgctc gtgtccatga taccggaaca aatgggcgga ttgatcccgg cgattgttgc 835381 cttaacaagc ggcattttca catttttgat gccgaatgac gcgtatttct acggggtgct 835441 gccgatttta tcagaaacag ctgtcgcata cggtgtggat aaagtggaaa ttgccagagc 835501 ctctattatc ggccagccga ttcatatgct gagtccgctt gtgccatcca ctcatttgct 835561 tgtcggactc gtcggagttt ctattgatga ccatcaaaaa ttcgcattga aatgggcggt 835621 tctcgcagtg atcgtcatga cggctatcgc tctattgatc ggtgcgatct ctatttccgt 835681 atgataattc aggcgtaatg acacacacta acggcataca acattccgga ggtgtcatta 835741 tgagtgatcc ttatatgccg ctgacttcag tcagaagcgg agcggggttc gaagcggcaa 835801 aaggggtgca cggcctgact gtgcaaattg cgaatgtcta ttttattcag ctgccttctg 835861 aacctcactc atttgtttta attgatgccg gcatgcccca atcagccggc gtgattgtca 835921 atgaagccaa acaaagattc ggtgaagggt ttcagctgaa ggcgattatc ctcacacacg 835981 ggcactttga ccatattggg gcaatcgaag agatccttga gcattgggat gtgcctgttt 836041 atatccattc tcgggaaatg ccttatgtaa caggtaaaga ggattatcct ccggctcgtc 836101 ctgacagcaa gagcgggctg gtcgctaagc tgtcgccgct gtttccgcgg cactctatcg 836161 atatttcctc acatgtccag gcactgccgg aagacggttc agttcctttt cttgacgagt 836221 ggatgtggat cgcgacacca ggacacacgc cgggccatat ttcgttattc cgcgatgacg 836281 gccgcgtgct tgtggcaggt gatgctgtta ttacagtgga acaggagaaa atggctgacg 836341 tcttgataca aaaacaggag cttcacgggc cgccggctta tttcacgcct gacacagaga 836401 cggccgctga gtccattcta aagctggccg gtcttgaacc ggaagcgtta ttgaccgggc 836461 acggcatacc gatgaccggc aaaaactttc gaagtgactt aactgaattg gcaaatcggt 836521 tatcgtctat ttgacacccg caccacgcgg gtgtttttta ttgttttcca ggaagttgca 836581 gaaaaatcat ttgtcttgcc gcttaaaaac gatacaatga aaagcatgaa gtgatgtgaa 836641 ggggagagtt tgttggaaga aaaagaaata ctctggaacg aagcgaaagc gtttattgcc 836701 gcatgctatc aggaattggg aaaggaggag gaagtgaaag accgtctcgc ggacattaaa 836761 agtgaaattg acctgaccgg aagctatgta catacgaagg aagagctgga gcacggagcg 836821 aaaatggctt ggagaaacag caaccgctgc atcggcagat tgttctggaa ttcgctgaat 836881 gttatcgaca gacgagacgt ccggacgaag gaggaagtgc gtgatgccct ctttcaccat 836941 attgaaaccg ccaccaataa cgggaaaatc agaccgacca ttacgatttt ccctccggaa 837001 gagaagggtg aaaagcaagt cgagatctgg aatcatcagc tgatccggta cgctggatat 837061 gagtcagacg gagaaagaat cggcgacccg gcttcctgtt ccctgacagc agcctgcgaa 837121 gagctcggct ggcgcggaga gcgaacggat tttgacctgc tgccgctcat ttttcgcatg 837181 aaaggggacg agcagcctgt ctggtatgag ctgccgcgtt cacttgtgat tgaggttcca 837241 atcacacatc cggacatcga ggcgttttct gatttggagc tgaagtggta cggcgtgcct 837301 attatttctg atatgaagct tgaggtcggg ggcattcatt ataatgccgc gccatttaac 837361 ggctggtata tgggcacgga gatcggagcg agaaacctcg cagatgaaaa gcggtacgac 837421 aagctcaaaa aagtagcgtc cgtgatcggc atcgccgctg attacaatac ggatttatgg 837481 aaggatcaag cgctagttga attgaataaa gctgtgctgc actcgtataa aaagcagggt 837541 gtcagcatcg ttgaccatca tacagcggca agccagttta aacggtttga agaacaggag 837601 gaagaagcgg gcagaaagct gacgggggac tggacgtggc tgattccgcc aatttcaccc 837661 gctgccactc atatcttcca ccgctcctat gataactcaa tcgttaagcc gaactatttt 837721 tatcaagata agccttatga gtaaacaata gaaaatcgat gatggccttc aaggctgcgg 837781 gattcagtca cagagatgtc ggtaaccttt gagaaagggc ttccgttctt tacagcctca 837841 acaaacgatt gcagggcgtt ttccggaccc tctgccaaaa tctcgacacg cccgtcatca 837901 cggtttttga cccagccggc cagttttcgc ttatcagctt ccatttgaac aaaatagcga 837961 aagcccacac cttgaacccg gccgtctaca atgattcggt attgaagcat gtaaaaacca 838021 ccttttcttt ttatgataat caatcatttt acaacctgta aaggggatgt gtttgtatga 838081 aacaagagcg ctattcagtt ctttctctta atctgggaaa accgcagacg cttgaatatg 838141 acggaaagaa aatcgaaacc ggcatcatga agcggccggc taaatcagcc gtcatgctgt 838201 atcgggagaa ttttgaagga gacggacagg cggacctcgt caaccacggc ggacctgata 838261 aggctgtctg tgtctacccg gcggagcatt atccgttttg ggaagagttc ctctcaagac 838321 cgctgtcaaa tgccgcattt ggagaaaatc tgacggtcgc gggcctgact gaggagaatg 838381 tttgcatcgg ggatgtgttc agacttgatg aagctgttgt tcaggtcagc cagccgcgcc 838441 agccgtgtgt aaagctggcg aaaaagtttg gtgtaaaaga aatggtgctg aaggtccagc 838501 aaaccggcta tacagggttt tattttcgcg tgctggagga gggcagggtg tctcccggcg 838561 cgaaccttga attgctgtcc agaggagaga aaggcatatc cgtccagttc gcgaaccgca 838621 tcaactacca tgatgcaaaa aatctcaccg ccattgaacg gattttaagt gaggctgcac 838681 tatcggaaag ctggagagcg tcctttatga aaaaaaagga caggctgctg ccggttgaat 838741 agaaaaaagc cgcgcatatc aacgtgcgcg gctttgccat atttaagatt gttttttctt 838801 tgattcaagc aggttggcaa gaaaataggt tttatagctt tgaagctttc ttccttcatg 838861 gtgcgtgatc ccctgctttt ttagttctgc cacataccag cctttactgc cgtaatgcat 838921 gtcagaaaac tcctttccct atctgatttc gaaacgattg gcattgtaac atctataaaa 838981 agatgctgaa aagagatgcg gggaaaactg agcctttcgc actagatgta cgaatgttct 839041 tctgaatgta tatgcggagc aaaagccgaa tatgatttaa tggccggtta gtttgatcat 839101 gacaacgcca aatgtcataa tggcgaaaac aatgccgata tatgtgagca tcccgttttt 839161 tttcttaacg ccgtaaacgg tcataatgat gccttcaatg aaaaaaatga tgccgaaaat 839221 aataaaccac atgcagataa aggctccttt cacagacata atagtagtgt agcatatctg 839281 aaagagccgg gctgtgacaa tatcaagaaa gccgggcgca tatcgcccgg ctcatgtttt 839341 attgtttatc aaccaatttg accagaagct gtgccaaatg ttctttctca tcttcgtctg 839401 caacgctcca aagctcttgc agcagcattt cttcaccgtt ttgcggctct tcatgctttg 839461 cgaggtagtc tcccaggatc gcagcgcttt ttacaagctt gccgtcatcc aatcccagct 839521 ttttgcctcg gttgacttgt tttttcaggt agcctttaaa ttcctcaaag tcttttaaaa 839581 tgtcttcttt tattgtgcca tgcatcgcgt tcatttcgtt ttcaatttgg attttttctt 839641 gatctctgtt cattgcaaga cctcctcgta cagaataatg atgctttacc tgcaattgga 839701 ggaggttaaa cctgccggaa gcccggaatg tgttttacag tttcgtcagg ataatcggtt 839761 catcttttgt gatgacgatc gtgtgttcaa cttgggcaac catgctttta tccggcgtct 839821 tgaacgtcca gccgtctcca gcttcaacaa tcgtttctgc tttcgttgaa ataaacggtt 839881 caagcgcgat gactgtgcca tttttgaaca gcgcattatc aaacggatca taatagttca 839941 tgatgtggtt cggcgcttca tgcaggcttc ggccgattcc gtggccggtc agggttttga 840001 tgacggtaaa gccttgagag cgtgcttcat gataaacggc tcttccgatc tggttttggc 840061 gcttgcccgc ttttgcctgc tgaagcccct tttgaaaagc gttttccgcg cattggcaaa 840121 gcttatgaag gcgttcttct ccttcaccga gcacaaatga gatgcctgtg tcggaataga 840181 agccgccaaa ttcagcggag atgtcgatgt tgacaaggtc ccctgctttt aaaattttgg 840241 atgtgcttgg tatgccgtga gccacttcat catttacgct gatacatgtc acacctggaa 840301 aatcgtattc cttctcagga gctgaaacgg cgccgtgctc atcaagcaca gcttttccga 840361 taaggtcaag gtcttttgtg ctcatgccgg gctctgcctt ccgcttcatt tcttcacgcg 840421 caagcgcgac gattcttccg atttttttca ggccttctaa ttcttgatcg tttgttacaa 840481 tcatctgtca ttcccgcttt ctttttaaat aatctagatt aagcttacca caactgtctt 840541 aaaaatagga aacacacgga cctgggaaaa aagaaatacc cccgggaaaa ttggtataga 840601 tcactagata tcttatatgg tatatttgaa aaaaaagggt atgaggggga tgggtatgct 840661 ttcattttta caaaaactcg ggaagtcatt tatgctcccg attgcggttc tgcctgcggt 840721 tggaattatc cttgcgcttg gcagagagga tgtatttaat atcccgtttg tctatcaggc 840781 ggggacggcg gtttttgatc atctgccgct tatttttgcg atcggtattg ccatcggcat 840841 ttcaaaagac agcaatgggg cagcgggttt atcaggggcg atatcgtatc tgatgcttga 840901 cgcggcaaca aagacaattg ataaaacaaa taacatggcg gtgtttgggg gaattattgc 840961 cggtttaatt gccggttaca cctataaccg cttcaaggat accaagctgc ctgaatatct 841021 cgggttcttc agtggcagac ggcttgtgcc gattttaaca gccattatta cgatcatttt 841081 agcgggcata ttcggagtgg tctggccgcc gattcaatcg tgtatcaact cgtttggaga 841141 gtggatgctc gggctcggcg gcatcggggc aggcatattc ggcctattca acaggctgtt 841201 aattccgctt ggccttcacc atgtgctgaa caatattttc tggttccaat tcggagaata 841261 taacggagtg acaggggatt tggcgcgctt tttcgcgaaa gatccgactg cgggcacata 841321 tatgaccgga tttttcccaa tcatgatgtt cggtcttccg gcggcgtgtc tggctatggt 841381 tgtgactgcg aagccgtcta aacggaaagc gacggctgga atgatgattg gatttgcttt 841441 aacggcgttt atcacaggga ttacggagcc gattgagttt gcatttatgt ttttatctcc 841501 gcttttatac gctgttcacg cggtcttaac cgggttatct ttatttatcg tcaactggct 841561 cggcatccgc tcaggcttct ctttttcagc cggagctatc gattatgtgc tcagctatgg 841621 aatcgcggaa aaaccgctgc ttctgctttt ggtaggtata tgctatgcgg cagtatactt 841681 tatcgtgttt tatgtactga ttaaggcttt gaatttaaaa acgcctggac gggaagacga 841741 tgatgtggat gaagtgctgg atgaaaatac tgttcaggat gtaaatgaaa acatcatgct 841801 gaaagggctc ggcggaaaag aaaaccttca aaccattgat cattgcgcca caaggctgcg 841861 actgactgtg aaggataccg ctttggtgga tgaagcactg ctaaagaaag caggcgcaaa 841921 aggggttgtc aaatcgggcg ggcaatcggt tcaagtcatt attggcccga atgtggaatt 841981 tgcagctgag gaattgaggg ctgctgtcaa ataaaaaagc ggagagggca acctctccgc 842041 tttttcttat ttatcttcgt tatcctttga cgtttcggaa gaatcttcgt catgttttgt 842101 gtaatcataa tcagaaggat tcaccttctt aaaacctttc ggctcgtaga accgcagcag 842161 gtctccgttt atgattttat cggacatttc aagttccttc ttgacgagtg agtcttctga 842221 cttgtcgact tcggattcat cgagttcttt tccggttttc gtgtcgtaat acttaccgga 842281 tattttcgtg tacttcggtg aaataaagtc tccgtttcgg aacggaatca cttcacggtg 842341 ttctttcgat aaaatatcag aaccggacat cagatagtcc ttcgtatcca ctccgagcag 842401 atgcagaatg gtaggagcca catcaacgtc tccggcatat ttatgaactt tctcgccctt 842461 cacgccggca gcgtggataa agagcggcac ccgttgaagc tgggcgttgt cgtaatcagt 842521 gatttcatcc ttgccaagca ctttcgccat cgctttattg tggttttcag agatgccgta 842581 gtggtctccg tacatcacaa taatcgattt atcatataac ccgtcttttt tcagatcatt 842641 gaagaattgt tcaatggact gatcaaggta atgggctgac tggaaatagt tatcgacgac 842701 agagtcacca aagtctccag ccgggaagtc tgtatccccc tcatccattc cgaatgggaa 842761 gtggttggaa agggtaatga acttcgtata gaacggctgc ggcaggcttt ccagcagcgg 842821 cattgattct ttgaagaacg gtttgtcttt catgccgtag tttttcgtgt tttcttcgtt 842881 catgtcatag taagcagaat caaagaattt atcaatgcct tccgccttgt acatttcgtt 842941 acggttccag aacgtctgcg tgttcccgtg gaaagtagca gatgtgtaat tcttagactt 843001 cagaatcgcc ggaacggatt gcagcgtgtt ttgcgctttg tttacgaaaa ctgaaccttg 843061 agccagcggg tacagagagt tttccatcat aaattcagca tcagatgttt taccttgtcc 843121 cgtttggtgg aaaaagttat caaagtagaa cgtttcgtta tcatgtgcca gtttatttaa 843181 gaatggtgtc acttctttgc cgtcaatttt atagtcgatg ataaatgact gcaaagattc 843241 aagtgaaacg taaatgacgt tttttccttc cgctttgccg aaatacacgt tattcggcac 843301 atcgtaattg gctttcatgt agttttctac ttccgttacg tcgctggaat cggcaagcgc 843361 gcgctggctg ttggacttga tattctgtac agcgtcataa atcgtgaaat tgtatgttcc 843421 caagtatttc acaagatagt tccggtcgaa tgatcttgtc agcaattcag gacggtctga 843481 ttccgcaact gccaggttga tcaagaacac aagaattgaa gacgcaaaaa taattcggaa 843541 cgattttttg cttgacgttt cggcaggctt gtttactttg atcgccaaga tgatcaggat 843601 gatcgtatcg ataaagtaaa aggcgtcagt cggtctcatc agcgaaaatg cgctgtcacc 843661 gagttggccg ccgtttgttt tagcctgcat aatgaccgga attgtaataa aatcattgaa 843721 aaatctgtag tacacaatgt tggcgtacag taaaaaagac attaaaaaat gaatcactat 843781 aatggctgtc tgctgtaatt ttttcttgaa caagagtcca aagccaagaa agaacaagct 843841 tgagctaaga ggattcacaa aaagcaatat tttttgtatc gtgttgtcta ttcctaagtt 843901 gaaattcagg acataaccga catacgtttt gatccataac aggacgaccg caattaagaa 843961 gaaggccagt cctctttctt ttataaatgt tttcattgtt acactccttt tttccgatcc 844021 agttcgagcg aaacgataga aaaaacgaac gtatccaata taacacgaat cagcagatta 844081 gaaaagtgaa aatcgtatga gggagaaagt ggcgaaaaac gccgtcgaat caacgtttcg 844141 ctttgatatt accaaatgta aaacaaggta tctttctaga aataaaggaa taaaatggta 844201 cattgagaat tgtatgataa aatataaggt atagataaaa agaggtgaaa tgatggattt 844261 ttcccatatt gtgtctgaag ataaaattaa gcgcgccatc aaagacgggg actttcaaaa 844321 cctcccggga atggggaagc cgctgccgaa ggatgacgcg gcacacttgc cggaatcgct 844381 gcgcatgggc tatcgtattt tgaaaaacgc gggaatggca gaggacgagg gcgcgctcaa 844441 aaaagagctt atgaccatcg accatttaat cgaaaagtgc tatgacgaaa aagaacgcga 844501 gcaattaatc agaaaaaaat ctgaaaagca attgctgctt gataagcttg tcgacaaaaa 844561 aggcatgttt tcaaagccag catccgcttt ttataagaat aaagtatatg accggcttgg 844621 acgaaacaga ccttcttcca gctgatttgt cttgtctgca ggatggcgat tgataaaagc 844681 catccttttt atgttccaag ttctatgtca aaaggtttat gtttttccat ctatgggaaa 844741 tgattcataa acgaaaaaag ggtgatggga tggaacgact attagtatgg atagagcata 844801 tatctgattg gctgtggggt ccgccgctaa tcatcctgct gacggggacg ggcttgtatt 844861 tcactatttt gctgaaaggt tttcaatttc gctatccttt atacattttc aaacagacaa 844921 tcggcagtgt aggaaaaaag ccgaagggag aaggcacagt cacaccgctt caggcattga 844981 cctcagccct cagttcaacg atcggtgcag cgaacattgt cggtgtgccc gccgctatta 845041 tgtttggggg accaggagcg gttttttgga tgtggcttat tgccttattt gccatggcga 845101 ttaagttttc tgaaagtgtt cttgctgttc attacagaga aaaaaatgag cagggtgaat 845161 acgtcggggg accgatgtat tacataacaa aagggctgcg catgaaatgg ctcggcgtat 845221 tcttctctgt tgcgctgatt gtggagctga ttcccagcat tatggttcag ggaaattcgg 845281 tttcagtctc gcttgccgag acgttttctt tcaataaaat atacgcagga atcggaattg 845341 catttttgat tgggttagtg gtgataggag gggtaaagcg gatcggaaaa gtaacagagt 845401 ttgtcgtgcc tcttatggca ggggcatacg caggtgccgg tctcctgatt gttctcatga 845461 atctatcatc agtgccggcg tttttctctc tcgttttttc aaatgcgttt acctcttctt 845521 cagcagttgg agggttcgca ggtgctgcgt tggcggaaac cgttcgctgg ggatttgccc 845581 gcgggctgta ttctaatgaa gccgggatgg gaacagcccc gattgcacat gcggcagcaa 845641 tgactgatca tcctgtgcgg caagggtttt ggtctgtgat cggcattgtc attgacacct 845701 taatcatctg tacgactacc gcttttatcg tccttgcatc cggtgtatgg acagggaaga 845761 acgcctcaaa tgacccggca gcactgacaa cggccgcatt tcagcactat ttcggttctg 845821 gaggaggata cttcgtttcg gtttccctgg tcttctttgt cgtatcaacc attatggttg 845881 tcatttttta cggcgtaaag caagctgaat ttctgttcgg gcggctggca ggacatgtga 845941 ttaaattcgt ttatttagcg gctattatca taggtgccgc aggcggagca aaagccattt 846001 ggggcgtatt ggacttagca ttggttttta ttgttgtccc gaatgtgatt gcgctcttgt 846061 tattgagcag aaaggtaaaa gcgctgtaca ccgaattctt tacatctgaa cagtactacc 846121 tgaaagatat aagaaaaacg aaacaaaagc ctgtttatcc aacaaaagaa gctaaaaatt 846181 cctagtgttt tgcttttgcg ccgaacaatg ctttgctttt tatgatcaaa taaatgagta 846241 aaggcagcaa aagagaaatc actacattaa tgattggttt gattctgtta aagtcgatta 846301 gctgatttgt atttaaaaaa aaccaaaagc cgcatacgac tgagaacatg ccggttggtg 846361 tatacatggc tttcgggtcg atttttgagt gtaaaaacga aaggccgtat accacgatat 846421 atagggaacc tgctatcttc accataatga ccggaatcca aaaagccgcg atgatcaggt 846481 ctgagcgatc cagaaaatcc gtaatgcgga tctgcctgat gaccatataa gcaggatcaa 846541 agaaagtaga tgtcaggttg ggaccaaaga cagaaattga agaaaataac atcacggcca 846601 gcaataaagc gcccagcagt atcgcgaaaa tggtgtattt tagcgggacg ctccggtttg 846661 agaagagaag cggaaggata atcaattccc ccattgtccc aaacgcgtaa tagcctgatt 846721 gaaggtatgg gattagacct tcaaaaacag gtgtcaagtt ttgaagctca atttgtgtgg 846781 ccagcgtaaa tggaaggaac aagaccagga tgccgaatgg aaataggaat atctgcgcca 846841 ttctggtcaa tgtttctttt ccctctctgg caatacagat cgccacaaag ataataacac 846901 cgccaagaac agccattggt gttctcggga gaaataaaat gttaatcaaa ttgatgaaaa 846961 aacgtatatc atgagcattg attaacagga aatacaaaga aaacagtaaa atgataatcc 847021 ggcctgcgat tggtgaggaa tcgctcagca gctcatagat atttttatcc tgatgctttt 847081 tcatcagcct atgcatgagc cagagtgccg gaatcacgat gacaacgccg aggatgtagc 847141 tgtgccaggc attttgtttt gctgattcga tcatgagaat cggagcatgc tttaatccga 847201 ctgctaacgt atacagagct ccgaaaaata atccttggta tgcagaggtc ttgtccataa 847261 agcacatcct ttctgtcatg ttcaaaacgg aatatattta aacaggtgcc ccagccgcgg 847321 aagcagggga ttcactctca tataaatcca tagaaaagca cttcctgcaa ttagcaggct 847381 gaaggcccat tttgttagat tgttagcgga acgaaaattc ttccattcat atgcgtatat 847441 ggcaatgcac acaatcaatg tctgtacgat atagctgatc atgctgacgc acctccatta 847501 atggctgatc gttttgtata ggacaccgcc ctgctcaatc gtcacaattg ggacgacgtg 847561 aacctccata tccttatata cctcttccca ttcctttttc agcagattct tcgtggttgc 847621 cgtgcttctg atggtcctgt cttgaaagcc ggccgggtcc gcctttagct tttgcaaacg 847681 atgaacggtg ctgatcacgt ccttctttat ggttctgttt aatgcttttt gaatgatgta 847741 atactggtca ttttctctcg tctcataggt tgattggttt tccataataa ttcctttggc 847801 tctgatctcg attgtcattg acagctttcc gtttttttca gcggcatgaa aggatgcatt 847861 ggacttttga agctgaatgg atgcttgccc catttgattc ggcaggtcta ctatgaattc 847921 tggctggcgg gcttgattca gcaacatcag ggctgctgtc atgtgttcat ctttgaaaat 847981 atccatcaat ctgtcctttt taaagatcgc aagcccgtca attttcaaat tagatttgcc 848041 tttccctcca ggttttgttt tagatgcaga gatgaccggt gcatacggat cactgcctat 848101 ttctactaga tcagacatga atctgcttaa gaaaacgggg cggctcgttg cgataatggc 848161 cagctcccga atcatttccg ccggaaactg ttcaagctga acatcggtat ttaaaatgtc 848221 ccgcgcttct ccccggctga ctaaaatgag cgccgttaat ctgttctgcg gatttcgcgt 848281 taaaatatca aagactgggg caacgccgtc tctcgccata tcctctccaa taatgactgt 848341 acgtctgtgg gacgtattga ttgtccgtga caaggaggtt tgcagcttgt tgttcgcttc 848401 tctgatcgta gtgccggaag ctgaatcaac ataccatgtt tttgaaccgg cagttccgcc 848461 gccgccccct gtttgtccgc ctaattggcc gaccaaggga atctgcatgg ccactcgata 848521 ctgatctttt ttcttatcaa tggctgagct gacaacaaat gcaatgtcat tgatttctgt 848581 ccggtcccag caccccgtta gaaggataca aatgagaagc ggcaaaacac acttatatat 848641 tgttttcttc atcttttggg tcctctcttt tcgctccctt ctgtccgttg ccgcgcgaat 848701 acgtgcccgg ccttctggtc atcgtccacc aaggcgccct gacaaaaata tcttttactt 848761 catctcgttt aaacggagaa atcccggata aataaggaat gccgaaagat tgcagcttgc 848821 ataaatgaag cactaagata atcgtgccga gcataatgcc gaatatccca aaaatactcg 848881 ccaaaaacat aagcgggaaa cgaagcatcc tgatggagat agctaagtta aaccgcggaa 848941 ttgtaaatga cgcgatccct gttaacgata cgatgatcac catgggggca gacacaattc 849001 ccgcttcaac agcggctgtc ccaatgacta gggccccgag aatactgacg gtctggccga 849061 tggttttcgg caggcgcact cccgcctcac ggagagcctc aaaagaaatt tccataatca 849121 atgcttctat gatggcgggg aaaggaatcg gttcacgcgc agaggccaca ctgaacatta 849181 agtttgtcgg cattaagtcc tggtggtatg taataacggc aacataaata gccggcaaat 849241 ataaagcaac gaataaaaac atatagcgaa gccagcggat taagttagac atcaaataac 849301 gctcatagta atcttcactg gcctgcataa gctgccaaaa cgtaatcggg cctgttaaga 849361 caaagggcgt attatctgtg aaaatggcaa atcggccttc gagaagctgg gcggcgacgg 849421 tgtccggcct ttctgtgtat tgcagctggg ggaatggcga gtacgtgtcg tcttcgataa 849481 attcttcaat atatccgctt tctaagacag catcaatctt tatctttttg attctttttt 849541 ttgctttgtc aataaccttt ggatcggcaa gcccgtcaat ataggccaag acaacatcgg 849601 ttttggtttt cgtgccgatt ttaaaagaga tcattttaag ctgaaacgtt ttgacgcgaa 849661 agcgcacaag agcggtattg accctgaggc tttcagtgaa gccctctctt gaccctctga 849721 tggtcgattc tgttatcggc tcttcaatgc ttcttctttg tccgcctttt atatttaaga 849781 tcaggccttt tgagtgcccg tcggcaaata aaaccgcgtt cccctcaatg atggatgcag 849841 ccactttgct catactcgtt tctaatgcaa cacttgaaat tgatagagta ttttgcagcg 849901 cctcttcatg ttcatctatt tgatccgtca aatgcattaa gaaagggcgg agggcgtgat 849961 cctgaatatg ttcagatttt acaattcctt cgatataaac aataaatccg cacagcccgt 850021 ttccaaagtc aaattgtcta aatacgatgt ctgagcagcc ttctgttaat aaggtcagat 850081 tttcgaggtt ttccttcaaa ttgggagaga tcggtctgtc ctgattgtct tcaagctctt 850141 tgatgagctg aagcgctttg tcgcgtttat tcatagaggc tcaccctgct ttttaatgtc 850201 atattcaata agtgcttgtg acttttaggg taaccttgtc tgtttcatat attccagact 850261 aggatgaaag cgctataaaa aagtgttgac tacctgtata tacaggaata caatatgatt 850321 ataagttgta tatacaagtt ataaaaacgg atacggaggg gttggcatgg gggaactgaa 850381 caaatcggca cgtcagattg tcgaagcagt cggcggtgct gaaaatattg cagcggcaac 850441 tcattgtgtt acacgtttgc gttttgcttt aatagatgaa agcaaggttg accaagagat 850501 gcttgatcaa attgatgtgg taaagggatc attctcgaca aacggacagt ttcaggtcgt 850561 aatcggccag ggaactgtca ataaagtata tgctgaactg gttaaggaaa cggggattgg 850621 cgagtcaaca aaggatgaag tgaagaaggc ctcagaaaaa aatatgaatc ctttgcagcg 850681 tgctgtgaaa acgcttgcag atatttttat tccaatattg cctgcgattg tcacggcggg 850741 tcttttaatg gggatcaata acattttaac ggcggaaggc attttcttca gcacaaaatc 850801 gattgtgcag gtttatccgc agtgggcgga tcttgctaat atgattaacc tgattgcagg 850861 cacggccttt acgtttttgc ctgcgttaat cggatggtct gccgtcaagc ggttcggcgg 850921 caatccgctt ctcggcattg tgctcggggt tatgctcgtg catcctgatt tgctgaatgc 850981 gtggggatat ggcgcggcag aacaaagcgg agagatcccg gtatggaatc tattcggcct 851041 agaggtgcag aaagtcggct atcagggcca ggtgctccca attttgcttg cttcttatat 851101 gctggcgaag attgaggtat ttttaacaaa acgcacacct gagggcatac agctgctcgt 851161 tgtcgcacca attacgcttc tcttaacagg atttgcctct tttatcatta tcggcccgat 851221 tacatttgcg atcggtaatg tactgacttc agggcttatc tcggtgtttg gttcttttgc 851281 cgcactgggc ggtctgttat atggcggttt ctactcagcg ctcgtgatta ccggtatgca 851341 tcacacgttt cttgcagtcg acctgcagct catcggttca aagctcggcg gcaccttttt 851401 atggccgatg ctggcgcttt ctaatatcgc acaaggttcg gcggctctgg ccatgatgtt 851461 tatcgtgaag gatgagaaac aaaaaggcct ctccctcaca tcagggattt ctgcttatct 851521 tggcattaca gagcctgcca tctttggggt gaatctgcga tacagattcc cgtttatcat 851581 tgcaatggtc agctctggcc tggccggaat gtatatttct tctcaaggtg tgctggcaag 851641 ctccgtcggt gtcggcggcg tgccggggat tttctcaatc atgagccagt actggggcgc 851701 gtttgcaatc gggatggcta ttgtattgat cgtgccgttt gccggaacat acgcgtatgc 851761 gagattcaaa cataaataac aagtggggag cgggacgtgt tgaacgttcc cttttcccgt 851821 tttcaattta aatatggtgg tggaaacaga tgaaaacaga acaaacgcca tggtggaaaa 851881 aagctgtggt ttatcaaatt tatccgaaaa gctttaacga tacgacagga aatggtgttg 851941 gcgatctgaa cggcattatt gaaaagctgg attacttaaa aacgctacag gtggatgtgc 852001 tttggctgac gccgatttat gattctcccc agcatgataa tgggtacgat attcgtgatt 852061 attactcgat ttatcctgaa tacggaacga tggaggattt tgagcggcta gtgtccgaag 852121 cacataaaag agacctgaaa gtcgtcatgg atcttgttgt caatcatacg tcaacagagc 852181 acaaatggtt tcgcgaggcg atctcttcaa tagacagccc gtaccgtgat ttttatatat 852241 ggaaaaaacc gcaggaaaac ggttctgttc cgacgaactg ggaatcgaaa ttcggcggct 852301 cggcatggga gcttgacgaa gcatcgggcc aatactattt gcatctgttt gatgtgacgc 852361 aggctgattt gaattgggaa aatgaagagg tcagaaagca tgtctatgac atgatgcatt 852421 tttggtttga aaagggaata gacggcttta ggcttgatgt catcaacctg atttctaaag 852481 atcagcgctt tccgaatgcg gaggaaggcg acggccgctc tttttacact gacgggccgc 852541 gggtgcacga atttctgcat gaaatgaacg aaaaggtgtt ttcacattac gacagcatga 852601 cggtcggtga gatgtcttca acaaccgtag accactgcat ccggtatacg aatcctgaca 852661 ataaagaact tgatatgaca ttcagcttcc atcatctcaa ggttgactat cctaacggcg 852721 aaaaatgggc cttggcgccg tttgattttt tgaagctgaa ggagatccta tctgactggc 852781 aaacggggat gcacgcagga gggggatgga acgctctgtt ctggtgcaat catgatcagc 852841 cgcgcgtcgt atcaagatat ggagatgatg gcgcatatag ggtgaaatcg gcgaaaatgc 852901 ttgctacggc cattcatatg atgcagggca cgccttatat ttatcagggc gaggagctgg 852961 ggatgacgaa tccgaagttc actgacataa gctcctatcg ggatgtcgaa tcgctgaaca 853021 tgtatcacgc ctttaaggaa aaaggaatgg ctgatcaaga tattacagcc attttacagg 853081 cgaaatcccg tgacaattcc agaacccccg ttcagtggga tgctacggaa aatggtggtt 853141 ttacaacggg cacaccatgg ataccggttg caggaaatta ccgggaaatc aatgctgaag 853201 cggcgctgag ggatcagaat tcggtgtttt accattatca aaaattgatt cagattcgca 853261 aaatgtatga cattgtgaca gagggtacgt atgagataat tgcaaaggat gacccgaaca 853321 tttttgcgta tctcagacac ggcagcaatg aaaagctgct cgtgatcaat aatttttacg 853381 ggacagaggc ggcctttaca ctgccggact ctttagcgcc tgacgaatgg aaggcagagg 853441 tgctgttgac gaacgatgaa gcaagggaag ggcttcagaa catgacgctt cgcccatatg 853501 agtccattgt ttatcgttta acgaaaccgt gttaaactaa gctgggtggt ccataatgaa 853561 ggtgaataaa ttcatcacaa tttataaaga catcgcacag caaattgaag gcggccgatg 853621 gaaagcggag gagattcttc cgtctgaaca tgagttgacc gcacagtacg gtacatcaag 853681 agaaacggtc cgaaaggcgc ttcatatgct cgcgcaaaac ggttatatcc agaaaatcag 853741 gggaaaaggc tccgtcgtgc tcaatcgtga aaaaatgcag tttcccgttt cgggccttgt 853801 cagcttcaag gagctcgcgc aaacgcttgg caaagaaacg aaaacaactg tacacaaatt 853861 cgggctggag cctccgtcag agctgatcca aaaacagctc cgggccaatc tggatgacga 853921 catctgggaa gtcatcaggt ctagaaagat tgacggggaa catgtgattt tggacaagga 853981 ttactttttc agaaagcatg tccctcacct gacgaaagaa atttgtgaaa actccatata 854041 tgaatatata gaaggagagc tcggtctttc gatcagttac gcccaaaaag aaattgtagc 854101 cgagccgtgt acggacgagg acagagagct gctcgattta cgcggctatg accatatggt 854161 cgtggtgaga aactacgtct ttttggagga taccagtttg tttcaatata cggaaagcag 854221 acaccgtctc gacaaattcc gatttgttga ttttgcgcgg cgggggaaat gagagaggcg 854281 cctgcctgcg gcagcgcgct tttttgtttg gtatcaaaat tgatactatc caacaaaaat 854341 gtgcgtactt ttacttttta tcataatggc tacaatagag atgagagtaa tctaaaggag 854401 aggtgtttta catggcagat ctaaagacac aaattctgga tgcatacaat ttcaggcatg 854461 cgactaagga atttgacccg aataaaaaag tgtcagacag cgattttgaa tttattttag 854521 aaacaggaag actgtctccg agctcactcg gccttgagcc ttggaaattt gtcgtcgtcc 854581 aaaatccgga attccgcgag aagcttcgtg aatacacatg gggcgcgcaa aagcagctgc 854641 cgaccgcaag ccatttcgtc ctgattcttg cgcgtacagc gaaggatatc aaatataatg 854701 cggactacat caaacgtcat ttaaaagaag taaaacaaat gcctcaagac gtgtacgaag 854761 gctatttaag caaaacagaa gaattccaga aaaacgattt gcatttgctt gaaagtgaca 854821 gaacattgtt tgactgggca tcaaaacaaa cctatatcgc gcttggcaac atgatgactg 854881 ccgctgcgca aatcggtgtt gattcctgcc cgatcgaagg cttccagtac gatcacattc 854941 accgtattct tgaagaagaa ggccttctgg aaaacggaag cttcgatatt tctgtgatgg 855001 tggcattcgg ctaccgagtg agagaccctc gtccgaaaac aagatctgct gttgaagatg 855061 ttgtgaagtg ggtttaaaag aagaaagctg ctcgcatagc gagcagctct tttttatgcc 855121 tgattcgctc tattctgttt tctcctctga tgtaagtaca ttgccgttcc gagtgcgctg 855181 atcagaaatc cggccaacag gatcgagtac atggatgtgg ctgtgtccgg aagcaggccg 855241 ccagccggac cgtctgttcc tgatccgccc gaaccgtttc caccagagcc gttagtcggt 855301 tgagtgccgg gaggcgtatc atttcctccg tttccgtcag ttggctgttt tccgcctggt 855361 ttgtcggagc ctccgccatg attgccgtca tcaccgcctg tcggttgatc tgacgggaat 855421 gccggcggtt tgttgtttga accggaattt aagatcgtgt attcgctgaa gtggtttgta 855481 tatcctgtca ccatatcatc atcgactgat ccgtgacctg tctttgtgaa agctttcttt 855541 tttctatcga cgtgataaat ggcagggtta tgggcttctt caatatcaaa catgcgaagc 855601 gaaagctgta cgggctcctt gaatgatttt atttcttttc ctttttgctt cactgtaaag 855661 tcatatacat ctgacagtga cacatccaat tctcccgtag acttgattcc gattgcagtg 855721 tctgcggttt taaggttcgc cattggcatc ttcatgctgt accagtagtt gaacatcgtc 855781 aatgaaggat ctgactctct ttctttcaaa agtttgacct gatctttttt cactttaaga 855841 ttgataggct tctcttgaga tccttcatgt attccataat agacaaatgg cgtgttggca 855901 tttttagcat aaatcgcaaa tttgtcttca tcaagtgtcc agctgccgtc cttctgcttt 855961 gtcggcagga atacttcttt gattcgtcct tcaactttag gagagacctt gtttcctagt 856021 tttttcagct gttcggtgaa aatctcataa tcaacgtagc caaggtcttc accatgggag 856081 gcttctgtaa agacagaata tccgtctcct ccggcaccga caaaattatt tgttgccacg 856141 cggtaggtat catccgtatt tatagcaact ttgtctccgt taggcgattc aattttcact 856201 tctaacacac ggtgtccagg tttgttgttt aatgtaaagg tatattcgat tccggccacc 856261 tgagggaaag cgccgccgcc attttccaca ttgcttaggc cttgttcaag ggcttcttta 856321 atttgttttc cggttaaatc ggccacgtaa agcgtattgc cgaacggcat cacgttgagc 856381 acctcgccga gtgtgatatc acctttgtca atgcctgctc tgatgccgcc gccatttgtt 856441 atcgctattc tggcgccggc tgcttctttc gcttttgcca gcataccgtc cgcgatgaag 856501 tttccgagat tcgtttcttt cgtgcgcaca tgctcacgct ggccgtcaag cgccacatcc 856561 gtgtagccga ctttttcatt tttcacgtcc tctaattcat ttttgaactg atcgagctct 856621 tgttttgctt ctgggttttc ttctgtatgt tcatcaattg gcagcacgct cagatttgat 856681 ttatctgttt gcacaacgcc tttttcatca aacgcgacat caacgcgccc caagaattgg 856741 ccgtattctt ttgcctgcgc cacgatcgtc ggttcttcgt tgttcacgac ctccattttg 856801 tctacgaggg tgtgagtgtg tccgccgatg atcaaatcaa tgccttttac ttttttggct 856861 agctcaagat cccggttatg tccgatgtgg gttaaagcaa taattttatt taccttttct 856921 tcttcttgaa tcgctttgac ggtgttttgt gctgtttcaa aggcatcatt gaatacgatg 856981 cttttgcccg ggcttgatgt ggtggctgta tcttctgttg tcaggccgaa tacggcgact 857041 ttctccccgt caacgtctaa cagaatgtaa gggtgaatgc cggcctcttt cttttcacct 857101 gccgtaaagg tttgcggctt tttgacaaat gatttcagct tgggctcatt tgacacatct 857161 acgtttgcac tgacaatcgg aaattccggc gcttcaaagt gatagcggtt cgccggatca 857221 acggttgcgc tgtttccgct tagaaaatca gaaagcaccg tcgggccttt gtcaaattca 857281 tggtttccga aggtcatggc gtcatagccc atcatgttca tcattttcag atcggccaaa 857341 ccgttccatt tagtaaaata cagatcgccg gaaaacacat ctcccgcatc aaggagaata 857401 ttgtgatttg tttcgctgcg tacttcgttg attttcgtca ttcgtctcgc tgcatcatcg 857461 agatgggcgt gcgtatcatt ggtgtgcatg acggtcagat cccacagtcc gtctttagga 857521 ggatctggat ttgaatcatc atcgaattgc agcttataca caccatagcc ttcattcgca 857581 gacttgccta cataagcgac atcgtctgct ttatcggcaa atggcttggc caaaagcgag 857641 gattcaaacg tcagattcgt gccggaaaca ggcgcgattg accagttgtt gtctgctttt 857701 ggattgactg ttttttgttc aataatgtaa tccatcagca cctgcctatt ttcaactgca 857761 gagccgtgga caattttatc gctcgtcaga tgagggaacc cgccgcctcc ggacgcacga 857821 tagttattgg tgactacgag aaattcctgg cttgggctga tcggcttgcc ttcataggaa 857881 agattgatga tacgggatga atccgcattg atcacttttc cgttctcatt gtatttagcc 857941 ggttttgtca catcgacctg atatgtgaca ccgtcaatca cgtcaaaatt ataggagcgg 858001 aaattctcgt tcagcaaggc ctggtcgccg cctttagctg gatcaatttg attgaattgg 858061 cctgctgaca tctccagcca gtccttgacc tcgctgcctg tcagcttgac gatttgaaca 858121 gtattatcgt aaagatacaa gtcaccgaca tttttaatcg caagatctcc ggctggaatg 858181 tttgtatagt aattggctcc gtttctgccg cctgctttaa acggcgctcc agcggataaa 858241 atcggcaggt tcttgtactc ggtatccttc atttcttttt cagcgtacca cttttgcgcg 858301 tcagtcacga tctgaatgga aggatcatct ttgacctgtg caaagaagct gttaatatct 858361 gcttcggttt tgccgactgg ctttcggaca tactccagtg tgttttggtg tgtttgctga 858421 atggtgtttg taacggtttc gtttcttgat gtgacgttgc cagcaataga ttcaatactt 858481 cctttggaat ctgctacctt ccatgagccg tccgcctttt caagcttgag gtcaatcacg 858541 cctaaatatt tgccccagct gcttggcatg acgacaggaa tgccgttaat tgttcccttt 858601 tccacattga actgagcaac acccgcatac tcggcggaag gaaagagtcc gtgctgatgg 858661 cccgagataa tcgcgtcaat gcctttcgtt ttggtggcaa ggtcaaacac ggcgttttct 858721 gcgcctgatg attgcgcctg cttttcaatg ccggtgtggg cgagggcaat aatgacatct 858781 gcgccttccg ccttcatttt cgggatcgtt tcattggcgg attctacgat atcctgcacc 858841 tgaacttgcc cctcgagatt ctttttgtcc catgtcatga tttgcggcgg gacaaagcct 858901 atgtagccga cttttacttt ctgctcatta ccgttttcat caatgagggt tttttcatta 858961 atcacatacg gcgtataacg gttttcgccg ctagttgttt tgacgttggc atttacaatc 859021 gggaaatcgg ctcctttgat tgtgccgtcg agaaagtcga gcccgtagtt gaattcatga 859081 ttgccaagcg ttccggcgtc gtatttcagc gcattcatga cgctgataat cggatgggtt 859141 ttcgtgccgg agataatgtc gtctttttga tatttcaccg cgtattcacc cagcggattc 859201 ccttgaatca agtcgccgtt atccacaagc agggtgttag ggttttgctc gcggtgcttt 859261 tggatcaatt gcgctgttct cgccagaccg aaatccgccg tttctttgtc gctgtagtaa 859321 tcgtaatcca tcatgttggc atgaatatca gtcgtagcca aaatactcag atgcacctga 859381 ggagccgcgc tttcttctgc atgaatgggt ggtgttggga ggattaggct aagtatcata 859441 attgggggca aaagaatacg gagaatgttt tcgacgtgtg ttcgtctttt ctgtattctc 859501 accagttctc cacctttcaa cgaaatttgt gttacagctc ctattgtaag aatattttgt 859561 aactatttgt aggtgtttct ttatgattat tgtaaaaggg agaaaaatga gtattatgta 859621 gcagtatcaa acgacaaata ctgggcattt atgcttatcg tttgtcacaa tcgcggaatg 859681 tttattttag tgtggctggg gtagagtgtt ttatgtagac atataaagcg ggaggttatg 859741 aatcatgggg aaaaaaattg cagttgtttt aacatattat tttgaggaca gcgagtacac 859801 tgagcctgcg aaagccttta aagaagcggg acatgaactg actgtcatcg aaaaagaaaa 859861 aggaaaaaca gtaaaaggca agcagggaac agcggaagtg acggttgacg cgtccattga 859921 cgacgtaaat tcttcagact ttgatgcgct tttgattcct ggaggatttt caccagacca 859981 gcttcgcgct gacgatcgtt tcgtccaatt tacaaaagcg tttatgactg acaaaaagcc 860041 ggtatttgcc atttgccacg gcccgcagct tttaatcaat gcgaaagcgc tcgacggccg 860101 aaaagcgacg ggctatacgt ccattcgtgt tgacatggaa aacgccggtg ccgacgttgt 860161 ggacaaggaa gtggttgttt gccaggatca attggtcact agccgcacac cggacgatat 860221 accggcattt aaccgcgagt cattggcatt gcttgagaaa taagaaaaaa cggacgctct 860281 tgggcgtccg tttttttgtt gcttaggctt gagcacctgt cagtttcttg tacctgtaat 860341 acaagaaagc agctgcagcc gttccgatga ccgcaatgcc gaagtcgaat atgaaaatat 860401 gggcgatgcc ccccgctttt gcgataagcc ctgttgcaat cggcagcaga atcgatgcaa 860461 gacttgaagc agtcgctaca attccggtaa cggttccttt tcgcttccag aaaagctctg 860521 tcattaacgt aatggtaatt tgaaacacac ccgcagttga aaagcctaag aaaaaggcag 860581 tgatgtccag cacaactggg atatgaacgg tcagcatgac tgcgagcgta cataaagtaa 860641 taataggata taagagcgtt atgaagacag gtttgaccca tctattcagc aaaacggcta 860701 ataataaaac agatgccaga gatcctatac tataatagct cagcaattgt acagatgctg 860761 attcagctaa accggctgcc ttttgcgcgt agctcgggag ccagatttga gaaaccgtaa 860821 ataaagccgt ggatgtaaaa ccgatgataa tcagtgcggt gccttccttc tgaaaaacgg 860881 gttcagacaa gaaaacggga gattcctgtt ggccgctatt agttggtttc ttatgttttt 860941 taggaaacga aagcgttgat aaataaataa tattcaggag atagaccgct gccggcagat 861001 aaaaagcaaa tccgtaaaac atgctgtggt ctgctaaaaa tgtgatcaaa agcggcaaaa 861061 gtgcggcccc cacagacata aaggctttaa ccaagacatt tgccgaaccg gaagcagacg 861121 gaaagagctc ggttagggcc ggatatgttc cggcatccat ggctgaatta gcgactccgg 861181 ctaataaagc gaacacaaac gccagctcat agctcggtga taaaggaata ccgactaaaa 861241 agacggccat aattcccgca gaagcgacaa caagcggctt tctgccgatt ttatctgata 861301 gaacgccgga aatgccgtat gtcagcagtt tgccaaaccc gatagcggca atgacataac 861361 tgatgccggt cggatcggta ttccactgtt ttgttaatga agacatattg gatgcgagaa 861421 tgatgttgac catccccaga aagaagtagt tgatatacat tccggatgct gttttgatag 861481 atgtcgtttg catgcttgta ctccttcaaa tcttattcga acactttgct gttttggttt 861541 ggggaaatga taaaaaagac tcgccgagtt tccggccagt ctccattatt tacgaagcga 861601 ggctaattct tgagcaatcg cctgcatttc acttgggctg aatgattctt ttttcatcac 861661 cattctgtga aggtacgtga ggtcttcaat cttctcatca ctgaaatcct ccgctttgat 861721 tacgccgacg ttcagcatgt tcagcttttg ggaaatctct tcaatcattt gagttaatgt 861781 ttctgtattt gggctggaca aagggttcca tcctttctat gcgcaatata ggtatgtttt 861841 attctaacag aattccatca gaaaaaaacc ctattctaaa agcaggctgt tcattccaaa 861901 aaagtgaaga catcagttga aaagaaaatg aacatcctac taagatattc atgaaggttt 861961 ctttttagag aaataggggc aaagaatagg gaggttgcac atcatgataa gcgtgttatt 862021 tgtttgttta ggtaacattt gccggtctcc gatggcggaa gcgattttta gggacctggc 862081 agccaaaaaa ggattagagg ggaaaatcaa ggcggactca gccggtattg gcggctggca 862141 catcggcaac cccccgcatg agggaacgca ggagatattg cgcagagaag gaatcagctt 862201 tgatggcatg ctggcgcgtc aagtcagcga acaggatctg gacgattttg attacatcat 862261 tgcaatggat gcagaaaata tcggaagtct cagaagcatg gcgggtttta aaaacacctc 862321 gcatatcaaa aggctcttgg actatgttga agattcagat ctggctgacg tacccgatcc 862381 ttactacaca gggaactttg aagaggtctg ccaattaatc aaaacgggct gtgagcagtt 862441 gcttgcatcc attcaaaaag aaaaacaatt gtgagtgaaa ggagaatttg catgaacaac 862501 gaacgtttaa tgctgaaagg gatatttctc ggagctgcgg caggcgcggc gttatcactg 862561 ctccataagc cgacaagaca ggcgtgcggg atgagatggc tgacatgcaa gcataaactt 862621 tcactgtaca aaagcaaccc agagctgtta aaaaacactg tcatcacaaa agtggatgag 862681 gccaaaaagc tcgcccgaac gctttcaaag gaagtcgact ttgtgaacca gcaggtgaaa 862741 gagctgaaga aaacaacgcc gcaagtgatg gaactcgtgc aagaaacgaa agagcatttt 862801 tcaaaaaaat gatcaaacat gcgaggtgag acgacatgag ttttttgaaa gagcttttca 862861 gcagatacac ccttcatgaa ggacaaagta aatcagcgga gctggcgtat ttttttctat 862921 tgtcactgtt tccgtttttg atttttatgc tgacgctcac cgcgtatctt ccgctttcta 862981 ccgatgatgt tttaggagtc atagaacaat atgctcccgc cagtgcgatg tcactcgttg 863041 aatccattac ccatcaaacc ttaaataatc gaaatggcgg tttgctgtca ttcgggatta 863101 tcgccgcatt atggtctgcg tctaatggaa tgaatgcgat cgtccggtcg ctgaaccacg 863161 cgtatgatgt ggaagaaaac cgctctttta tcattgttcg tctaacctcg atttttttga 863221 cgattgccat ggtatttacg attttagtgg ctttgcttct gccggtattt ggccgggaga 863281 ttggaaggct cgcttctgac tttgtcggcg cgtcggatct gtttttatcc gtctgggccg 863341 ccattcgctg gggtgtcagc ccgcttgtgc ttttgattgt tttttccgcg ctgtatgtga 863401 ttgcgccgaa caaaaagctg tctctccggt ttgtcatgcc gggtgcggtc tttgcgacta 863461 tcggctggat cattgtcagc acattgtttt cattttacgt cagcacgttt gcgaactata 863521 gcgccactta cgggagcatc gggggaatca tcgttctgat gatttggttt tacttgagcg 863581 gcattttaat tatcctaggc ggagaaatca acgctctttt acataaacgt aaaaagcttc 863641 ctgatgaaaa tccctaccat tagcgcaccc tataaacgaa cttcggttca aaaagaagtc 863701 ggggggatat cgtgatgacc aagcatacga aaaaaggcgg aagccataac aaacaaaact 863761 cgaaaagcaa atcgagccat aaaacaagcg gaagcgccaa cggacaaaac ggctaccatt 863821 agcataaaag cctcctgaca tgatgtcggg aggctttttg attaagaaga tgaagaatag 863881 gtttcagccg gtgaccagct tttcggtttg cccagcacaa gggccagcca cacagagcta 863941 agcgtgagag taatgaagta gaacaagttt gcgctttcaa atgtctgcat ataccagccg 864001 ccggcaactg ggccgaggat gctaccgaga ctgaatgtaa tgccgcaaag caggtttccc 864061 gccggcagga ggtgaggcgg aagaaggtct gtcatatagc tgatgccaag tgtaaaggtt 864121 gatccgactg ccattcctgc aataaaaaag cagccgccga tcacgtaggg cgaaggaaat 864181 acaccggcga tgaaaaagca aagagcccca gtcagtaaaa tcaccagcag cacattccgc 864241 ctgccgtatt tatcgctgag gatgccgagc ggaaactgaa agataatgct tccaatcgca 864301 aatgcgggaa ggatgatcgc tactgcgtct actgatatcc ccaaacggag cgcgtacacc 864361 ggaaagcttc cgttcagcgc cgtttccaga aagccatagc caaatgtagg cataaaggca 864421 acccacccaa acagcatggc ctgataaaat cgcctgaaac tattgtctga tttggtttca 864481 tgaggactgg tttccgggta tgcattttgt agaaagaaaa caaaaagcca cgcaaacaga 864541 ctgatgcagc cggacacgat aaaaggaagc gacggactca gcttgacaag cggcaccatg 864601 aacgggcctg cggcaaagcc aaggccaaag gaaagcccat aaatagacag gtttcttccg 864661 cgattttgtt ttgatgacat ggaggtcacc cacgtttgcg tagaaaagtg aagcatgtgg 864721 tcgccgattc caatgaacag gcgaagcagg aaccagaccc aaactgactg aagccaaata 864781 aatccgaata agcttaaaat gacaatgctt ccgcccatga cgatcagcgg cttgaacccg 864841 agctttctga gcggtgcttc cataaacggc gaagccaaaa gcacaccgat atacagcccg 864901 gtcgcgtgca ggccgttgat agcagcggat tctccatttg tttcaaaaat gattgaaatg 864961 acaggcagca gcatgccttg tgaaaacccg gaaatggaaa cgagcaagac aaggataaag 865021 aaatgaaatc gtgacatcgt gtcagttctc cttatatgga atctatgttg atcgtacaac 865081 gttttccaaa agcaggcaac ctgaaaaaag cctatatcac gctatacatt tgccctcgtg 865141 taatcatgaa ggtttttgtg aagaataaaa ataaaacaag tcataaaaaa ggagctattt 865201 caccatgaat cgtatctttt ttattttagt ggcggccggt gttccgcttt ctgtgattgg 865261 cagtttgatg cattggcctt ccgcggttct atttgcagtt tattgcgtga cgattatcgc 865321 gcttgcaagc tatatgggga gggcgacaga atcactgtcc atcattgcag gaccgcgtat 865381 cggcggtttg ttgaatgcaa ccttcgggaa tgcggtggag ctgattattt ccctttttgc 865441 attaaaagaa ggcctgacag gaatcgtgct tgcctcttta accggttcag tgctggggaa 865501 cctgttgctg gtagcgggcc tatcgttttt tgtcggcggt ttaaaatata agcggcagga 865561 atttaatatc catgatgccc gccataactc cgggcttctg atttttgcca tcattgtcgc 865621 ctttgtgatt ccggaggtat tctctgttgg tatgggaaac gccagcaagc tcaatttaag 865681 catcggcatc agcatcatta tgattctgtt atatgtggcg gcgctgtact ttaaacttgt 865741 cacgcatcgg ggcgtttatc agccgaataa tgccgctcag actgaagaag aggaagagcc 865801 agaatggtca gggaaggttg cgacgattgt cttgtttgcg gcaacgattg tggttgcata 865861 catatccgaa aacctggtcc atacctttca ctcggtggct gaacagttcg ggtggagcga 865921 gctgtttatt ggggtcatca tcgtggcgat tgtaggaaat gcggcggagc atgcgtcagc 865981 gattattatg gccttcaaaa ataaaatgga cattgctgtt gaaattgcag taggctctac 866041 gctgcagatc gctatgtttg tcgcaccggt tctcgtcatc tgttctatct tttttccgac 866101 aagcatgccg cttgtattta cattgcctga gctcgtcgcg atggtatcag cggttctctt 866161 gatgatcgcg atttcgaatg acggggattc caactggttt gaaggggcga cactgcttgc 866221 tgcatatgtc attatggcga tcggcttttt ccttctttaa cctgaaaaaa tgatggataa 866281 caacaaagcg ggatgaaaag actaagggaa aatgccatag aaagagtgat atgatgaaaa 866341 agctatttca ttccacactt attgtgttgt tattctttag ttttttcggc gttcagccca 866401 tccacgcgaa aaagcagttt aaggttccta attctgtcgc aagcatttca aaggaaaaca 866461 cgtatccgaa tgcttcacag gatcagccaa tgcttcagcc gagcaagctg gcaaaggaat 866521 tgctcgatca ttctgaggta aagattgaaa atccgcatct catcaaaatg ctgaatgaat 866581 ccaacatatc cggcacaccg cttgcagtag ggtaccgggc gacaatattt ctcgggaaat 866641 gggcgctcgg ctatgaatca aatgaaacag tcgcaaactg ggaatataaa aaaatcaata 866701 caaaccgtgc ggataaccgc ggcgggaaag aaacggctga aatgcattat gcccaggaac 866761 agcagtacag agtgaagggc ggcttgacag ctaaagttcc aaatgctgaa gatgtcaaaa 866821 gcatgatgat gcaaaaagca atgaagaaaa cgaacctccc gcttgcattt gagacggtca 866881 tcggggctgg cacaaaacgg gatcagattt ataaagtcgc tcctaaaaaa atcggttatc 866941 tacatgcata tgcaccggct gtgaatgaaa aaggaaaagt gacttacgga gaagtgtact 867001 tagtgctgaa aggaaataaa cgaaaactcg tcgtgaaaaa tgtcacgtca cagggaatcg 867061 gcgcgtggat tccggttcaa gatcatgtca cgtttggctt tcagctttcc tcactgccaa 867121 gataaataaa aaactgattc caactcggaa tcagtttttt tgtttattgg gttctctcga 867181 ttcggaccgc ttcctcaagc atttgcacat tgttttggta gagctggcga acgagaaccc 867241 gtcttactgc aaggctggca ctgaaataat catcatcttt caccatgcct ttaaccgtaa 867301 attcgacgcc gcgattgatt ttattcaatg cggtgatgcc gtggatttga aacggttctg 867361 tcggattgcc gaattcatcc cgcttcaatg aatcacgaag ctcttcattc agcatgtcac 867421 atgcctcttc caacacgctg tacacgcggt ccggatcttc tttaaagctg ataagaaagg 867481 attcggtaat ccgcataaaa tcaatattat agttctctat ttgtctgacc tcgccgttgc 867541 tgatggtgag cagcttcccg ctccattccc ggatttgcag cgagcggagg ccgatttcct 867601 ccactgtccc gttgaacaag ttgttgacgg tgacataatc gcctttgtgc agctggcgtt 867661 catatattaa gaatacacca gccagcacat ctttgatcag cgattgggcg ccaaaaccga 867721 tcacgatacc tgctacgccc gccccggcca atatcttgcc gaaatcatgc acaaataaag 867781 aaataacgta aaagataaaa ccaattgttg ccgtatactg ggtgacagaa cggacaaggc 867841 tttcaatcgt tttttccttt ttttcttcaa taaagtccgt ccgtttaaaa aatagctgta 867901 ccagccggtt gatgataaag acaccgatcc aaaggataac ggcaacgagg agaatatcga 867961 cgattttatt ttgaaaaatc tccgtaagtg tttctttcat ccgcatctaa ctcctggctt 868021 gacgttttgt gaagtctgta tcctgataat aactgttttt gacaagaaca ttcggtccga 868081 ggcaccggac attcgggcag tggcaactca gttctttcgc aagcttggtc tctctccact 868141 tttcataggc ggaagggagg ctgtccgtct gaatgttgcc aagcggcggg gtatcaccga 868201 aatcggtcac gataatgttt ccgtcgaaaa tgttcacatt caggcgggat cggccgtcag 868261 ggtcatttcg cactgtgacg tttttcgccg cgcgaagccg gcgaagcagc ttttggtcgt 868321 cttcgtccgg actgcaggca taaaacggca gcgttccgaa cagcatccac gtattttcat 868381 cacgaatatc cagcaagcgg tgaatggcct gtctcatctc tttcaggctg agggattcaa 868441 gagcgcttgc gaaatcgctt ggatacattg ggtggacctc gtgacgctga catttcatat 868501 cttctgtgat ttggcggtga atatgctcaa tatgcggaag tgttcgtttg ttcagcatcg 868561 tttccgcaga taccattact ccggcatcca cgagcgtgcg gctgttttcg atcatttttt 868621 caaaatagcg cgcgcgctgt tcgaaggtcg gttttctgtc catcatggca aagccgattt 868681 cagcaaaatc ttcaactgtt ccccagttat gtgaaatatg tagcacatcg agatacggaa 868741 tgatccattc gtaccgctcg atgtcgaggg tcagatttga attaatttgt gtccgcacac 868801 cccgttcatg ggcatatttc aataaaggaa caacatattc ttttactgat ttcaacgaaa 868861 gcatcggctc tccgcctgtg atgctgatgg atctgaggcg cgggatttcc tccagccgtt 868921 ttaacagaag atctattggc agagcattcg ggtctttagg ctgcaatgta tagcctacag 868981 cacaatgctc gcatctcata ttgcacagtg tcgttgttgt gaattcaacg tttgtcagct 869041 gcatgtctcc gtattggtca acatccatat aggcttccca agggtcaaac tcgggcgtaa 869101 tcggacgcag cttcgtgttt tgtgtcatga ctatctaact cctttataaa tgggcatact 869161 aacgctgcca acagttaatt ttagacctga tttgccaaga tcgcaagtag cgcggcgatt 869221 gaaaaacggc aaaaaatgag ctaccataat aaaaaatgaa tggaggaaca gaatggggaa 869281 cgccgtaaac aataaagatc agcagattga ttatttaaag aacagacttg acatgtttat 869341 gaacgtcatc gattcattag accctgaagc aaccgacgtt gaagatatag acaggcttat 869401 cagcatgctt gatgacctgg aagccaaata cgaacgtttt aaaaaagatt gggaataaaa 869461 ccgcgtgccc gccgcggttt ttttattggc ataaagcaac agtataaaac aaagtctcta 869521 tctgtaaaat aagaaaaaat gcagaaggag cgctggccat gaagtggatg tgttcaatat 869581 gctgcgccgc cgtattgctt gccggaggtg cagcacaggc ggaagcggtg ccgaatgagc 869641 cgattaattg gggctttaaa cgaagtgtca atcatcagcc gccagatgcc gggaagcagc 869701 tgaacagttt aattgaaaaa tatgacgcgt tttatttagg gaatacaaag gaaaaaacga 869761 tttacttaac gtttgataac ggatatgaaa atggctatac gccaaaagtg cttgatgtct 869821 taaaaaaaca tcgcgtaaca ggaacgtttt ttgtcaccgg gcatttcgta aaggaccagc 869881 ctcagctgat caaacgaatg tcagatgagg gccatattat cggcaatcat tcctttcacc 869941 atccggattt aacgacaaaa acagctgatc agattcagga tgaacttgat tcagtcaacg 870001 aagaggttta taaaattacg ggaaagcagg acaacctgta tttgcgtccg ccgcgcggcg 870061 tgttcagtga gtacgtactg aaagaaacga aacgcctcgg ctatcaaacc gttttctggt 870121 cggtcgcttt tgttgattgg aaaatcaaca accaaaaggg aaagaaatat gcctacgatc 870181 atatgatcaa gcaggcgcac ccgggagcca tttacctgct tcacaccgta tcgagggaca 870241 atgcagaagc gctggatgac gcgattacag atctgaaaaa acagggctac acttttaaaa 870301 gcattgatga tctgatgttt gagaaagaaa tgaggctgcc gtctttgtaa aagagaaaga 870361 cctctcctta aacggagagg cttttcttta ttttatacat ttaatcagtg cggcccagtc 870421 cagatccccg aagcctttct caatcccgct ttcaaaatgg ctcttggcca gctcggcaag 870481 aggaagattt gcagaaaccc gttttgcggc ggcgagtgcc aggttggtat ccttcagccc 870541 taaagacatt ttgaagccgg ccggctcaaa tttctgctcg gccataatgg ttccgtaatt 870601 ttgatagact ggagaaccaa agagcgcgct ggcgatttct aaaaattgtt tttgttctaa 870661 gccgtatttc tccatcatta aaaaggattc agataacgcc tccagcatgg acacaagcaa 870721 gaaattaatg ctgattttgg ctgcatttgc cgtcttgctt tcttcgccga cgtcaaatat 870781 ctgctggctc aggctgtcga gcagaggctt ggcagcttgc tttgcttccg ccggtccggc 870841 tgttatgata cggagcgcgg ctttggctgc ggcatccggt ctgccaagga caggagcggc 870901 gagaaaaaat tgtcctttct ctgcatgagc cgctgcgagc ttttctgaga actcaacact 870961 gattgtgctc atcgagatgt gtatgccgtt ctctgctaat ccttcaagca gcccgtcttc 871021 tccgaatgtc acggtgctga cagaatcatc atctgcaagc attgtgatga caatatcagc 871081 ggactttgcc gccagccgcg gcgtatcagc tgcctgtgcg ccttctgtga caaggtcttc 871141 tgtcttttgt ttcgtccggt tatagacagt caattcgtag cctgcttgaa gaacatttcg 871201 ggcaatgggc tgtcccatat tgccgagtcc gatgacagca attttcaatc taatcactcc 871261 ctgaatattt tttccattat aaacaatatg aacagaatat gcatagcgat cggcttacaa 871321 caaaaaagaa cagctgctcg ctgtcctcat ttaaaaatat tgaaccatcc tttatgtaca 871381 aaccaaatca gcattccaat cacaagcgcg gccatcaggc caagtacagc gaaatatccg 871441 tatttccaat gcagctccgg cataaagtcg aagttcatac cgtatacacc ggcaataaag 871501 gtgagcggga tgaaaatggt tgatacgatc gtcagtgtca tcataatcgc attcatccgg 871561 tttgagttta gcgtcacgta gctgtcacgc aagtcggacg tcatgtcacg gttggattcc 871621 acaatttcag acaactttaa caaatgatca tatatgtcgc tgaaataggc tttcgtttcc 871681 cgctgctctt tcacatggtc aaggcttaaa atccggtaga gcaaatcacg catcgggata 871741 atcgtccgtc tcaaatgcaa taggtctgtt ctgagatcaa acacctcgtt catcagcgtt 871801 ccatacgttt tgtggggacg gctttcttca atttcattca gccggtcttc aattttatac 871861 acgagaggaa aatattcatc aacaagctga tccatgatca tataagaaat atgcccgggc 871921 ccttttttca atatgtccgg tgaagcatac aaacgctccc ggactttagc gataccgggc 871981 gtttcgtgta aatgaaaggt gacgacaaat ttttcgcctt gaaagatatc gacttcctcc 872041 gtctcaagtg tttccttatt cagcgcatga atcacgtaaa aacgatagcc gtcataatgg 872101 tcaagctttg gccgctgcat atgctggaag caatcctcaa tggcaagcgg gtgaaaatga 872161 aaaaaatctc tcaataacgc cgtttccgta tcctccgggc cgtaaaaatc aacccagtac 872221 catgcaatat caggctgttc cactcgttcg atcggtatat ttttcagcag ctgatgctct 872281 gttgtgattg cggtaatgtt gatcataaac aaccctccac ctgccattat atcatgcggt 872341 ctttatgaga aaagtatacg gtactctctg cctaattcca gcggcatgtt atactgaaca 872401 aaaacggaaa aaagggtgga tctcatgtgg aaggaaaaag tatctgtcac gcctccgtat 872461 cattttgacc gcgtgctgga caggctgtct ttagaccccc tcaatgctgt tgatcgagag 872521 gcgagggaag tccgtgtgcc aatcagaaat caagcggggg acgtatgtat tgtaaaggta 872581 caggcgttag gccatgcggg cgagcctgag ttcctcgtca gcggggaaac ggatcaggga 872641 gaaatgatga aggaaatcaa gcggattttt caatgggaaa atcatttgca gcacgttctg 872701 gatcattttt caaaaacgag cctgtccgcc atttttgaag agcatgccgg gacgccgctt 872761 gttctggact acagcgtgta caactgcatg atgaaatgca ttatccacca gcagcttaat 872821 ctttccttcg cttacacgct aacagaacgg tttgttcatg cgtttggcga gcagaaggat 872881 ggcgtgtggt gctatccaaa gccggaaacg attgcggaac tcgattatca ggatctgcgt 872941 gatctgcaat tcagcatgag aaaagcggaa tacaccattg atacatcaag gatgatcgca 873001 gaaggcacac tcagcttgtc agagctgccg catatggcgg atgaagacat tatgaagaaa 873061 ctgatcaaaa tcaggggtat cggcccgtgg accgtgcaaa acgtcctcat gttcggactt 873121 ggccgtccca atttattccc gcttgccgat atcggcctcc agaatgccat caaacgccac 873181 tttcagctgg acgataagcc ggcaaaggat gtcatgctgg cgatgagcaa ggagtgggag 873241 ccttatttaa gctatgcgtc tttgtatttg tggaggagta tagaataatt cgtctgacaa 873301 tgaaggaaat cctgcaaacg tgttatacta gaaagatgtg aaaaaaccat ttcactttct 873361 gccatccgca gaaagcttca tatagaaacg gagagaacaa cgtgaaccaa caaaagaaac 873421 aggcgcccgt cgaactgaag gtcggacaaa cttttccgct gacgattaag cgtctcggca 873481 ttaacggaga aggtgttggc tattttaaga aaaaagtcgt cttcgtgccc ggcgcgcttc 873541 ctggcgaaga agttgttgtg caggccacaa aggtccagcc gaagttttcg gagggccgca 873601 ttaagaaaat ccgcaaggca tctgagcacc gggtggcacc gccttgccct gtttatgaac 873661 aatgcggcgg ctgtcagctt cagcaccttg catacagcca gcagcttcgg gaaaaacgtg 873721 atatcgtcat tcagtctctt gaacgccata cgaagtttaa agttgaaaac atggaaatca 873781 aagaaacgat tggcatggac aacccgtgga attaccgcaa taaaagccaa ttccagatcg 873841 ggcgctcgca aagcggcagc atcatcgccg gcttatacgg ccttgattct catgatatcg 873901 tgccgattaa agactgtatc gttcagcatc cggcaacgaa caaaacaaca ggcatcgtcc 873961 gccgcatttt agaggacttc aatgtgtctg tttataatga aagaaaacga aaaggcgacg 874021 ttcgcacgat cgtgacgaga gtcggctttg aaacaggcga agtgcaggtc gtgcttgtaa 874081 ccgcaaaaga aacgcttccg cacaaggaag aaatcgtcaa agcgattcaa aagcgattgc 874141 cagaggtcaa atccattatt cagaatgtaa acggggcgaa aacctcagtg atttttggtg 874201 agaaaacaaa acagctcgcc ggaaaaacag tgattcaaga agtgctcggc gacgtatctt 874261 ttgaattgag cgcccgcgct ttcttccagc tcaatccgga acagaccgtc aagctgtatg 874321 atgaagtgaa aaaagcggcg cagctgaccg gaaaagaaaa agtcgttgat gcgtattgcg 874381 gcgtcggcac tatcggcatg tgggttgcgg acggagcgaa ggaagtccgc ggcatggacg 874441 tcatcaagga atcaattgac gatgctaaga aaaacgccaa aaaacacggc atggcaaatg 874501 ccacatacgt aacaggaaca gccgagcact ggctcccgaa atggacgaaa gaaggcttcc 874561 gcccggacgt cgtcattgta gacccgccaa gaacgggctg tgacagcacg ttcttggaca 874621 cgatcaaaaa agtcaaaccg aaacgctttg tctacgtttc ctgcaatcca tccacgcttg 874681 cgaaagattt gcagacgctg tcgaaggact atcgcgtgga ctatattcag cctgtcgata 874741 tgtttccgca gacggcgcat gttgaagcag tggcgaggct tgtattaaaa tcgtctaact 874801 aaaaagaaca tttcccagtc ataaaatagt tttcctaata agacctggat ttcggtaaaa 874861 taaacaattc cgatttccgg gtctttttcg tgcgcagctc ttgtcctaac ggtctgttct 874921 caattttatc ttccttcttt tcgcggagat ctttatttta actggcgaaa agaattgaaa 874981 aaacgtgttg aaaagcaggt gaaaaaaagc gttatttaac cggaaaaata tcctcccagt 875041 atgtttaaaa tacatgagta gaatgatgta aaatcataga tgtattttca taatttgtaa 875101 aattatatat tgacttgcag ttattacgtg tgaaatattg atgataggaa tataaggaaa 875161 gtatggcgta tatcatttca agagtcattc gatgtaaaaa gttgaaacat tgtaataaat 875221 gaaagaggtg aaaatgatgg ccaaccccat tttaaaatgc ataacgtatg agcactacaa 875281 caattaaata atagtgccga gacgataaca actattacag taatacctac aatggttata 875341 tccttgcgac aatcatgctt cataatataa tgattttaga ttgacacttg gctaaaaagt 875401 attgcagaga aggaaatgga taattaaatg gataaagtat ataaaagaag ttggtttcaa 875461 acatttttgg catttttagt atctcagctt tattttaatt ttgtagaatt aacgggatgg 875521 ggtcctaagt atagagaaat gaatggattc ccagcaaaca tagttgaact agatttcttt 875581 caaacatatc tttcattcta tgataatcca tggtttaata ttattactgt tttcttggga 875641 gttttcacta ttatacaaat aattacaggg ataacaaagg atattcgaaa ttaaagcaat 875701 aacttctgat gccttattta atgatgaaag aaaatgtaca ctttcttaat tatcttatga 875761 gtgaagactg cgacacttag tcagcagtct attttatggt tctggatcag gattaccgaa 875821 ttataaccct atacaaatat atagtaggtt gccacttgct gcgttggtta ttttctaaat 875881 catgagcaaa tcccaaatga ttcagattga agttcttgaa ttcttttaaa taagggttta 875941 ttttctcttc tcatcctctt tactccatgt gattcacaag tggtagcagc ttaagtaggt 876001 tttttcattc tcttgagtac tcagttatac cacccccaac tcaatttgct ttatctctat 876061 tagtttttcc gcaaatatga tatagagata cggatatggt gtagtgttaa atatcttatc 876121 ttcaataaca gggcaattat tttgcgttgg taatatggag aactcatatg atattctatt 876181 taggttggaa tcctttttat ccaaaaagtt caaaagcaag gccactaaga aagacgaagg 876241 tcagcgccag ttaaccagaa tataaaaaat agggtagata atcatcccac gtgaaatctt 876301 caaaatttac tatagattga taagaaatgc tttcgcatgc gataagtgta aaagaagcat 876361 ggtcagtttt taatttggga taaaggttca gccgtatccc ataatgaaag gatttgattt 876421 ttgttatgac agaaaatttc tggcgtgaat taccacggcc gttttttgta ctggcaccaa 876481 tggaagatgt gacagatgtt gttttccggc atgtagtaag tgaagcaggc agaccggatg 876541 tgttttttac agagttcaca aactcagaga gctattgcca cccggatggg aaggatagcg 876601 tgcgcggccg tttgactttt acagaggatg aacagccaat tgtggcccat atatggggag 876661 ataagcctga aaacttccgt aaaatgagta ttggcatggc agagttagga tttaaaggac 876721 tagatatcaa tatgggctgc cctgtgccta atgtggcggg gaatggaaag ggaagcggcc 876781 ttatttgccg tcctgcagtt gcggcagaat taatacaagc tgcaaaagca gggggattgc 876841 ctgtaagcgt gaagacaaga cttggataca cggatgtgga tgaatggcgc gagtggctga 876901 cacacatttt gaaacaggat attgcgaatc tttctattca tctgcgtaca agggcagaaa 876961 tgagcaaagt agatgcgcat tgggagctca tcccagagat taagaaactt cgtgacgagg 877021 tggcaccaga tacattgcta acaataaacg gggatattcc tgaccgtcaa actggcttga 877081 aacttgctga acaatacggc gtcgatggaa ttatgatagg gcgcggtatt tttacaaatc 877141 ctttcgcttt tgaaaaggag ccgaaagagc atagcagcaa ggaattgctt gatctcttaa 877201 ggctgcatct ggatctccat gatgaatatt caaaagaaga agcccgtcca tacaagcctc 877261 ttcctcgctt tttcaagatt tatctccgcg gattccgagg ggcaagtgaa ttaagaaatc 877321 aatgcatgaa cacaaagtca acagatgaag tgcgtgcatt gctcgacgac tttgagagaa 877381 agtatcttga tgggatagag taacagcagt gcttgattca aaaaaggcta acaaaataaa 877441 gggattttta cacaattctt gactaaaata aacctggatt ttcggtaaat ccgggtcttt 877501 tttgtacgca gcttttactc agcctgtctt ttctctaatt tattgtaaga aaataatggt 877561 atatttagtg gagatatcat ataaaggggg agaggaaaat gaaacggcta tgcatcatcc 877621 cctgcggcaa gaaaaaaatc tgggatgtcc agcctgatgc cgggccggta agagcagagg 877681 acgcttatct cagcccgttt catcaggcgt gcgagcggta tgcaaaaaca tttttcgatg 877741 agtgggtgat tttgtcggcg aagcacgggt tcctccgccc tgatgatctc gtttcgggaa 877801 attacgatgt cacttttggc accggtcatc cggaaatcat gacagcggac gagctgcgcc 877861 gtcaatttca cgaaaaaggc ttttctgata tcgaagagct agtcatgctt ggcggaaaaa 877921 aatatcgaag cgttctaaac gccgtcatcg gagaacacca gcatatcagc tggccgctat 877981 catcatacaa aggcataggc tatatgctcc aagcgctgaa ccgggctgtt gaagaaaagc 878041 atgaactgta gcacgtacat atgaggaaaa gagtgggaac atgaaaaaac ttgtgtttgg 878101 cttgcttgcc attgtgttat tcggatgcgg actatatatc tatcatgtat ggttcggtga 878161 tccattttcg aaaaatgctg cagaacagaa gctagtgtct tatgtgaaac aaacctatcc 878221 taagaaagaa atcaagatca cgaatggggt atataacgct aaaacgtctg aatatgtatt 878281 tgaagcaacc tcccaatctc atcgctaccc aatgtgtacg aagggatttc tgcatcctaa 878341 agtaacgtgc gatggaattg aagaagcgta taccgaatca gtagcaaaac atgtaaatga 878401 agaagcaacg aaggcaatcg aagcagatct gaaaaaagcg gttcctcgat ttataaaagc 878461 tgatgctgct ttgagtatcg aaaacggaca gttcacgtta gatacaaaat ggaacaaaaa 878521 gctggctgaa aaagcgccta tgagcatgac gattcagtta gacgccagcg ggttatcaaa 878581 aacagatgcc gcaaagatgg cggaaacggt cagaaaaacg cttaatgaaa agggatatac 878641 atactcaaac ggcacgatag actgtatgca gaaggacggg gacggcggta ttggatatgt 878701 caaatattca attgattttc tttcaaaagc agctattcag tcaaacgatg cagaggaact 878761 aggaagttaa aaagatttcc aaggaaataa atacgtcgat cattgtcaaa ggccgggtga 878821 tatccggtct tttttttgca tgctgtaaaa cgagacaaat gaatcagttt gagacaaaac 878881 gagacacacg tctcaaactg tctccaaagt gaagatgaga agactgattt tacgggctca 878941 aaagactggc acacttcttg catttataat ggtgaaccct aaatagaagg aggcgcacaa 879001 aatgaaattg ttaaaacgag aaggcttgtc attaactgag gaaaaagcgc tgtggatgta 879061 ccaaaagatg ctggagatca ggggctttga agacaaagtg catgaactgt tcgcccaggg 879121 agtgcttccc ggattcgttc atttatatgc cggtgaggaa gccgtggctg taggggtgtg 879181 cgctcattta catgatggcg acagcattac aagcacccac aggggacatg gacattgtat 879241 cgccaaaggc tgtgacctgg acggcatgat ggcggaaatt ttcgggaaag cgaccggatt 879301 gtgcaaaggc aagggcggtt ctatgcacat tgcggatctt gataaaggca tgttaggcgc 879361 aaatggaatc gtcgggggcg gctttacgct cgcatgcgga tcagcgctca cggctaaata 879421 taaacagact aaaaatgtaa gcgtttgctt tttcggggac ggggcaaata accaaggtac 879481 cttccacgaa gggctgaatt tagcggctgt atggaacctt cctgtcgtat ttgttgctga 879541 aaacaacggc tatggcgaag ctaccccatt tgagtacgca tcagcctgtg attcaatcgc 879601 cgatcgggcg gctgcttata acatgccggg ggttacagtt gacggcaaag atattttagc 879661 agtttaccag gcagccgagg aagcgataga aagagcaaga aacggcggcg gcccgtcttt 879721 gattgaatgt atgacctaca gaaactacgg ccatttcgaa ggagatgccc aaacctataa 879781 aacgaaggat gaaagagttg agcaccttga agaaaaagat gccattcaag gttttaaaaa 879841 ctacctttta aaagaaacag atgctaataa gctgtcagac attgaacagc gtgtcagcga 879901 atcgattgaa aaagccgtct cgttcagcga agacagccca tatccaaaag attcggagct 879961 gctgacagat gtgtatgtgt catatgaaaa aggaggaatg taagagatgg cgagagtcat 880021 aagcatgtca gacgcgatca atgaagcaat gaagcttgcg atgagaaaag acgaaaatgt 880081 gcttttgatc ggtgaggatg tcgccggggg agcggcggtc gatcatttgc aggatgatga 880141 agcatggggc ggtgtattag gggtcacaaa gggactcgta caggaattcg ggcgtacaag 880201 agtgctggac actccgattt ctgaggcagg ctatatggga gcggctatgg ctgcggcatc 880261 aaccggtttg agaccgattg ccgagctgat gtttaacgat tttatcggca cgtgctttga 880321 tcaggtgatc aaccaagggg cgaaattccg ttatatgttc ggcggaaaag cgcaagtgcc 880381 gattaccgtc cgcaccacat acggagcagg gttccgggcc gctgcccagc attcacaatc 880441 gctgtatggc cttttcacga gcatccctgg actgaagaca gttgttccat ccaatccgta 880501 tgatgccaaa ggtcttttgc ttgcagcaat agaagataat gatccggtgt ttttctttga 880561 agacaaaacg tcctacaaca tgaagggcga ggtgccggaa gattattata caattcccct 880621 cggaaaagcg gatatcaaac gcgaaggcaa tgatgttacg ctctttgcag tcggcaagca 880681 ggtcaatact gcgcttgaag cggctgcaca gctttcagag aggggcatcg aagccgaggt 880741 ccttgatccc cgcagtctgt ctcctctgga tgaggatgcg attttcacat cgttagaaaa 880801 aacaaaccgg ctgatcatca ttgatgaagc caatccgcga tgcagcattg ccacggatat 880861 tgctgcgctt gtcgctgaca agggctttga tttgcttgat gcgccgatta aacggattac 880921 agcgccgcat acaccggttc cgttttcacc agtgcttgaa gatcaatatt tgccgacacc 880981 agataaaatt gtcagcgtca cgcttgaatt gcttggcgag ccggcattga attaaagggg 881041 ggacacaaat ggcggtaaaa gtagtgatgc caaaattggg aatggccatg aaacaagggg 881101 aagtatcgat atggaataaa aaagtaggcg acccggttga aaagggagaa agcattgcca 881161 gcattcaatc ggagaaaatt gaaatggaga tcgaagcgcc tgaaaaagga acgctgatcg 881221 atatcaaagt gaaagaggga gaagaggttc cgcccggcac agctatctgc tatatcgggg 881281 acgccaatga gtcggtgcag gaagaggcgg gggcgcctgt tgctgaagac aatatgccgc 881341 aagccgtcca gcccgtcaaa caagaaaaca aacccgcagc ctccaaaaaa gatcgaatga 881401 aaatatctcc agtcgccagg aaaatagcag aaaaagcagg attagaccta aaacaactga 881461 aaggaactgg accaggcgga cgaatcgtga aggatgacgt aacaaaggct cttgctgaac 881521 agaaaaaaga tcaagcaaag cctgtttcgg agcagaaagc gcaggaaatc ccggtgacag 881581 gcatgagaaa ggtcatcgct gcccgaatgc aggaaagcct ggcaaacagc gcgcagctga 881641 cgatcacgat gaaagctgat atcaccaagc ttgccactct tcaaaaacag ctttcaccaa 881701 ctgcggaaga gagatacggc acaaaactga cgatcactca ttttgtctca agagccgccg 881761 ttctcgctct gcaagctcac cctgtgctga acagctttta tcaaaatgag cgcatcatca 881821 cacatcccca tgtgcacctt ggtatggctg tagccttgga aaatggctta gtggtgcctg 881881 tcatccgcca tgctgaaaag ctatcgctga ttgaactggc tcaatccatc tcagaaaatg 881941 ccaaaaaagc acgcgaggga cgtgcgggaa gcgaagaact gcaaggatct actttctcca 882001 ttacaaacct tggcgcgttt ggagttgagc atttcacacc gatactaaat ccgccggaaa 882061 caggcattct cggcatcgga gcaagctatg acacaccggt gtatcaaggg gaggagatcg 882121 tcagaagcac gatcctgcca ctcagcctga catttgatca cagagcgtgt gacggcgccc 882181 ctgccgctgc attcctgaag gcgatgaaaa catatttgga agaacccgca gcattaattt 882241 tataggaaaa gcaggtgaaa acgacatgac attagccatt atcggcggcg gacctgcagg 882301 ctatgcggct gcggtttccg cggcacagca gggcagaaac gtgctgctca ttgacaaagg 882361 caagcttggg gggacctgcc tgaatgaagg ctgcatcccg acaaagtctt tgttagaaag 882421 cgcaaacgtt cttgataaaa tcaagcatgc cgacagcttt ggaatcgaac ttccggcagg 882481 tgcgatatca gtcgattgga gtaaaatgca aagccgaaaa caacaggttg tcagtcagct 882541 tgtccaaggc gttcagtacc taatgaagaa aaatcaaata caggttgtaa agggaacagc 882601 ctcctttctt tctgaaagaa agctcttgat cgaaggagaa aacggaaaag aaatcagaga 882661 ggcggaccaa gtattgattg cctccgggtc agagccaatc gagctgcctt ttgccccatt 882721 tgacggcgaa tggatcctcg acagcaaaga cgcgctttct ctttccgaga ttccgtcttc 882781 actagtcatt gtcggcggcg gtgtcatcgg gtgtgagtat gcagggctgt tcgccagatt 882841 gggatcgcag gtgaccatca ttgaaacagc ggaccggctg atcccggctg aagatgaaga 882901 tattgcccgt ctctttcagg agaaacttga ggaagacggt gtcgaagtgc atacttcatc 882961 cagattaggg cgggtggatc aaacggccaa aacggcaata tggaaaagcg gtcagcgaga 883021 gtttaaaacg aaggccgatt atgtgctggt ggcgatcggc agaaaacccc gtcttgacgg 883081 attgcagctg gaacaggccg gagttgattt ttctccaaag ggcattccgg tgaatgggca 883141 catgcagacg aacgtgcctc atatttacgc gtgcggagat gctatagggg gcattcagct 883201 cgcgcatgcc gctttccatg agggcatcat cgctgcttct catgcttccg gaagggatgt 883261 caaaatcaat gagaaacatg tgccgcgctg catctatacg tccccggaaa tcgcgtgtat 883321 cggaatgaca gaacgacagg caagaagcat atacggggat gtgaagatcg gcgaattttc 883381 attttccgca aacggcaagg cgctcattaa acagcaagcg gaaggaaagg tcaaaatcat 883441 ggctgaaccg gaattcggcg aaatcgtggg tgtctcgatg attggcccgg atgtaaccga 883501 gctcatcggc caagcggcag cgatcatgaa tggtgagatg acggcagata tggcggagca 883561 ttttatcgcc gcccatccga ctttatcgga aacattgcat gaggcgctgt taagcacgat 883621 cggccttgcg gtacatgcat aataaaggaa aaagcaggcg catggatata aggcgcctgc 883681 ttttttattg ttgaaagcgc tttatttttc ccctacaata gatgaaaacg gcgtgtaagg 883741 gaggagcgat caaggaaatg aattcggtcc caaacgattt gcaaacctgg aaacgttttg 883801 tgaaagacgg tgtgcttgac gaagcccgat taagaaaacg gattgcagag tcatggcatc 883861 gctgcaaaaa agctgaggtc aatccttatt tagaaaaagg cccgaaggtt ttacagcaaa 883921 cggagctgga tcagcagtca aaaaaacatt cattcttctt gacgaccgca aagccttacc 883981 tcgaaaaact gctgcctgcc ataaaagaaa tggaaatgat ggcgctgtta attgattcag 884041 acggtgttgt tctggcattg gacggccatc cgcgcgcgct ctatgaagcc aaacgcatca 884101 atttcgtcga aggggcatgc tggacagaaa cggctgtcgg aacaaatgcg attggcacgg 884161 cgctccacat cagcgagccg gttgcaatac aaggatcaga gcattactct atcgcttccc 884221 atctttggaa ctgttcagct gctccgattc accatgagga tggcagcctt gcgggtgtaa 884281 ttgacatatc atgcccggcg gcaggcgcgc atcctcatat gcttggtatt gccacggcga 884341 ttgcctatgc cgctgaacgg gaactcgcag ctaaaagccg tgagaaagag ctggagctga 884401 tcagccgttt tggggagaga gctgcatcca gtgtgccgat ggtgctctgt aataccaagc 884461 agcacatcat cagtgcgagc atgccgattc gaacctcaat gccggattgg cagggccggc 884521 acctgtacga gttgaaggaa cggggctatt caatcgaaaa tgctgtcacc ataggagatg 884581 gcggcacttg tttttatctt tcggaacaaa agaaaaagaa ggcgtttcga ttcaatggag 884641 tgatcgggca aagcggccga tcgcaagcga tgctgatgca ccttgaacga gcagctgcga 884701 cggatgcatc ggtctgtttg tcgggtgaaa cgggtacggg gaaggaggtc gcggctcgcg 884761 cgcttcatga gaacagtgag agacggcacg gtccgtttgt tgctgtcaat tgcggagcga 884821 ttccgtctga tttgattgaa agcgaactgt tcggatatgc agagggcgct tttacgggag 884881 cgaaacgaaa tggctataaa ggcgcctttc aaaaagcgaa tcaaggcaca ttatttttag 884941 atgaaatcgg agaaatttcc cactcgatgc aggttgcact tttacgggtg cttcaggaac 885001 gcaagataac gccaatcggc gggacgaaag aaattccggt tgatatcaga gttattgccg 885061 ccacacattg tgatttacgc gagcttgccg aaaacggaaa aatcagagag gacttgtttt 885121 accgtcttca tgtctatcca attgaactcc ctccattacg cgatcgcacc gaggatatcc 885181 cggatctctt tgagtactac aaacagaaga atcattggcc aggcgatctt ccttctgatt 885241 tttgtaatgt gctgaagcaa tggaagtggc cggggaatat ccgcgagctg tttaatgtgt 885301 ttgaacgtct ttctatcaga tttccggacg gccggctgag agatgaatcg cttcccgctt 885361 tactggaagc cgctggattg ccggccagct ctgcagaaaa aaagccggct gctgccggcg 885421 tgcttacttt tcgtgagcaa atccaaaagg atatgatgat caaagcgctt gaatctgcaa 885481 aaggaaacgt ctctcaagcc gcaaaaatca gcgggatccc ccgaagcact ttctacaaac 885541 gcctgaaaaa attcaacttg tccgctgaat cataaagcat acttccttca ggaaatggaa 885601 acgttatgta ttgaaggagg gtgttacgat gaatattcaa agggcgaaag aaattgtaga 885661 atctcccgac atgaagaaag taacatataa cggcgttcct atttacattc agcacgtaaa 885721 tgaagaaact ggaacagcaa gaatttatcc gcttgacgaa ccgcaagagg agcatgaagt 885781 gcagctgaac agcttaaaag aggattaaac aaaaatggcc cgcttcataa gcaggccatt 885841 ttgttatccg cgcggcgcaa ataaaataac acagacaccg atgagacaaa tgaatgcgcc 885901 gatccagtca tacagatcag gtgttttccg gtcaacaagc catccccaca ggaccgcaag 885961 cacgatgaat actccgccat aagcggcgta tacacggccg aaagatggga aggactgaaa 886021 cgtcggaaga atgccgtata caatgaggat cagcgccccg gcgattccgt agccagctgg 886081 ctttgcctct ctcagccata gccaaaccag atatccgccg ccaatttcag caagccctgc 886141 cgcgagaaat aaaagaatgg taatcagcat catgagcact cctcaatttg catttatctt 886201 tcattataga ggaggagagc ttttaaagct tcggatgatt ctcaaattcc ttcaaatacg 886261 cttttcgctg aacctctgta aattggctga tccaattgtt ttgagcctct tcattcaaat 886321 ggggaaggat atagcgttca accgcttcga aaaacagcgg attcgtgatg atgttccagg 886381 tcgggattcg aacgattttg ccgtctgttt tctcgatgat aatatcctca aaaaagatcc 886441 ctttcaaact gtattgatgg cgtcccatat aaagccgctt cacctcggaa aacagcacgc 886501 tgcgctttct caagaagatt tcgccactag gtccggtctt tatggtgaaa atgacatttc 886561 cacggcttgt gaacgcagga aaagccataa agaatgtgat caatccataa atcatcgcca 886621 gtaatccgcc gcccaaataa agcagggcat atttagattc aaacgtgagg gcttcagaca 886681 ccagccagac tcccacaata aaggcgcccc ctgtagcgag gaacagccaa gcccttagaa 886741 acatcatgct ttttacttca atcatgtgct gcccctaaag cttcggatga ttctcaaatt 886801 ccttcaaata cgcactgcgt tggatgtctg taaactgtcc gatccaattg cttttcgcct 886861 cttcattcag atgtggaagg atatagcgtt caaccgcttc gaaaaacaac ggattcggaa 886921 tgatgttcca agtgggaatg cgaatggtct tctgatccac ggtttggatc aatatatctt 886981 cttggaagat tccttttaga ctaaatttat ggcggctcat ctcaattttc ttgatatcag 887041 taaacgtaac agacactttg tcagtgaaca cttctccatt ttttcctgtc ttgatgcgga 887101 aaatggtatt tccccgcggg gtgaaagccg gaaagaagat gataaataaa tataaacaaa 887161 acaaggtgaa cagaaagcca gcaggaatgg ctaataggta atatttcgtt tgaaacgtaa 887221 tacccatata aaagagccac aaacatgcta atcccatacc ggcagatccg acaaaagccc 887281 atattctcag gaacattttg cttttgactt caatgatttc ttggtttttc aatgcttttc 887341 tccttttgtt aattcaattc ttatcatttt gaaatgattt gatttacaac atccttatga 887401 gcagggagga tagaaaattc attctgggtg atgcctgtga caagccaagt atggtgggcc 887461 cccggcagga cgaatgccat gtcagccact tcaggagtgt tatcttttcc atatgccaga 887521 cgcataagtg tatccatttt ccctttccgc aaagccagat catttgcaaa tcgggtaacg 887581 tcctcttggt ggtcatgttt ttcaaggaac tcttttagat atgaagggtt gtctgaagcg 887641 ccctccaaga gtttttcaaa ttcatttgat gtcaatgtta caatcgattc tcttttatcc 887701 tctgtatcta ttatatgtaa aaactcatct gtcttagcaa gtaacccttc acttgattcc 887761 atttttgtaa tgcgatggac ttgttcatca aaaaggagtt cgtgagagta ggtgccgaat 887821 tttgatacat ggcatgacac attctgttcg gcaccttgcc cgttaaattt agaaagcttc 887881 actgtatagt cagcgtcgtt taatacatgg ataaacggac agtactcgtc ctttaaccga 887941 tattgatggt tccgatattc cgctgcatcc ttggctaaga gtgagcggca cgcggcttca 888001 aataaggcgc cgagctgttc atcttctatt tccggaaaat aggcctgctt caaggccatt 888061 ccctgttcaa aaaacccttc gctgtaaaag caaaacaaga gttcttctat gctaattgta 888121 aactgcttca ttgtttattc tcctatccaa atgaaaattt ccctttaagg aaatgggttg 888181 cgccgtgtat aagcgaatcc gctgttttct ttgctttttc cattcctttt ttcgcgctgt 888241 ctatcccttt atgtatcgat ttattcgccg catctatgcc gtcattcact gatttgacga 888301 ctttgccggc tgattccagc ccttttttgg ctgtatcaac aacagcatgg atcggttctt 888361 tcagctttaa ggctgctttt tcagcaaaac cggctgtata tttggcgatt tgttctccga 888421 cgactccgcc aatgtatgaa cctgctgccc caagaaggac agtacccaca ggtcctgcaa 888481 agcttccgat tgcaccgccg atgacagcac cagctgtggc accgccggca acaaaaatcg 888541 tattattcac agcattcccg acggccttgg cgttttcacg cttgagaact tccggtttat 888601 cctggtattt tgcataattt tcagcaattt tcacgcctgc tccgaatgtt tcggtcgctc 888661 cggtaatcag tgtggcggta atggcatttc ctttcgcgaa tctcaagccc gtttttccca 888721 catccttcaa agtggagcgt acgccggctt cattaagaaa tccttttgtg tagcttctga 888781 cgctgtttga aaaatccacc gtgtcctgag gaaagtattt tgtaaacttt ttatgtacca 888841 aatctgaaaa tggacggttt gtctttttca acaaatattt aggattcaaa agcactcttg 888901 ccgctttttg ataacgtgag ctgtcaacgg ccctggaaat atccaagagc agttttgagt 888961 gctgggctgt atgcaagccg cttggttgtt tcacaaattt cgtaagccct aatccgtaat 889021 attttccctg cgtcagcata agagcggtta agcttgtcat cgtaccgtat ttgtcgtagg 889081 cattgtagag ctttcgcaaa atatcatctt gttccacaaa tttatcgcct gtttttctga 889141 tgaaaatctc attgtcactc agcttagtga cgagcgcctt tcctgagctc cacgcatcgc 889201 ccactccaga aaaacagctg ctgtagcggg gatcgcattg caaaatcatc tgccccagct 889261 ccacatgcag gtccttatat ttgttttcca tatcagttaa ttcagtgact acatcatttg 889321 caagctgttc gagcttatcc ggatcaactg caatgtttcc tgacacaccg ttcacctccc 889381 gagtttatgt ctttcctctc ttgctttacg ctccagttct tccattctgg caatttcagc 889441 ttttcgttct tctattttga cagcggcagc cttcagctct tggcttgttt caagcagctc 889501 ctgttcgaat tgatcgtagg cggctttcgt ttcctcgaaa tcctggtcaa acgaatctct 889561 tgctttgccc tgccaagcat ctcccaatgc agataaccgg gattcaagca gcattttgga 889621 gcttctgacc tcttctgcgg ccgcactata cttgtttgcc agctcaatga ctttatatga 889681 gtccaacttt tgtcccctgc cttttctaaa ttcacgcaca attggatgtt ttatataaat 889741 gattataaat aattcggcat gtatccgaat cgtacaaaag aaccttttca taagaattgg 889801 aagggcgtat attcacttaa aattcacagt tggtgagact ttaagattac aaaaaaggta 889861 aaaaaaccaa atctctcaga cataaggcaa atgagaaatt tcccgctcta tgggaaaaaa 889921 cactaaagtt gatcaaatga cctaagtgcg ccaaacgtgt tacgggacga gctatctcat 889981 ggtataaatg gaattgtaaa cgttatcaag gaggtcgtca tatgaagaaa aaatcattct 890041 caatcgtaat agcgggcgga gggagcactt tcactccagg gatcgtactc atgctcttgg 890101 accatttgga ggagtttccg atcagaaagc tgaagctgta tgataatgat aaggagagac 890161 aggatcgaat tgcaggcgcc tgtgacgttt ttatcagaga aaaagcgccg gatattgaat 890221 ttgcagcgac gactgacccg gaagaagctt ttacagatgt cgattttgtt atggcgcaca 890281 tcagagtagg gaaatacgcg atgcgcgcgc ttgatgagca aattccgtta aagtacggag 890341 ttgtcggcca ggagacgtgc gggccgggcg ggatcgcata cggtatgcgt tcgatcggcg 890401 gtgtgcttga aatattagat tacatggaaa aatactcgcc tgatgcgtgg atgctcaatt 890461 attccaatcc ggcggcaatt gtggctgaag ctacgagacg ccttagaccg aattctaaaa 890521 ttctcaatat ctgtgatatg ccggttggga tcgaagaccg gatggcgcaa attcttggct 890581 tatcctcaag aaaagaaatg aaggtccgct attacggatt gaatcatttc ggctggtgga 890641 catcgattca ggatcaagag ggcaacgatt taatgccgaa gctgaaggaa catgtatccc 890701 aatacggtta tattccgaaa acagaggctg aagctgtgga ggcaagctgg aatgacacgt 890761 tcgccaaagc gcgtgacgtg caggctgcag atcctgacac actgccgaat acgtatttgc 890821 aatattattt gttcccagat gatatggtga aaaaatcaaa tccgaatcat acgcgggcga 890881 atgaagtcat ggaagggcgc gaagctttta ttttcagcca atgtgacatg atcacacgtg 890941 aacagtcctc ggaaaacagc gaaattaaaa tcgatgacca cgcatcgtat atcgttgatc 891001 ttgcccgggc gattgcctac aacacaggtg aaagaatgct gttgattgtt gaaaataacg 891061 gtgcaattgc gaactttgac ccgactgcga tggttgaggt gccatgcatc gtcggctcaa 891121 atggacctga accgattacc gttggcacca ttccgcaatt ccagaaaggg ctcatggagc 891181 agcaggtatc cgttgagaag ctgactgttg aagcgtgggc agagaaatcg ttccaaaagc 891241 tgtggcaggc gctgatcctg tcaaaaacag tgccgaacgc gcgtgtggca agactcattc 891301 ttgaggattt agtggaggcc aacaaagact tctggcctga gcttgatcaa agcccaaccc 891361 gcatatcata aatgaaattc ccccattttc gaatctgtaa ttgtatataa tagaaagaaa 891421 atggggggat ctgatatgca gctcgaagaa ctgatcaatc agcactacag caaattgaat 891481 gacaacgatt ttcatatttt aaaatatata ttgaatcata agcacacatg ctatcacctt 891541 ggaatcgacg cgctggccaa agcttgcagt gtatcgcgtt cctcaatttt acggcttgcc 891601 caaaagctcg gtttcagcgg ttacagtgaa tttcgcgtct ttttaaagtg ggaagatcag 891661 ccggaagaag gcgagagtat gagttttgaa aagctgcttg atgatattga agcaaatttg 891721 aagtttttac ggacaaagga catgacggac atgtgccagc tgattgatgc agctgaccgc 891781 attttcgtct acggttctgg aaatgcgcaa aagatatgcg cccgcgacct gcaaagaatg 891841 tttattccgc gccatcgcta tcttattttg attgaagaca caaatgaatt taatttgatg 891901 cgcgatgatt ttaaagtgaa cgatctgttt atcatcattt ctctttccgg agaaacaccg 891961 gagctgattc ctcaggcaag aatgctttct gcaaagggta ttccctttat ttccattacg 892021 aatttaaaaa acaatgtcct cgcccagctg actccgcata atctttatgc gacaagcaaa 892081 cctgtgacat taagcgatag aacggaaatt gtcgcttttg caccgttttt tctcgttggc 892141 gaagcattgt tccgcgcata tgttgattac aaagaggcag aaaaaaatga caatgagtag 892201 cagggggttc tggtatgatg caaaaaattc agcgctttgg aagcgcgatg tttgtgcctg 892261 ttttattatt cgcgttcgcc ggcattatcg tcggtatcag cacgctcttt aaaaataaaa 892321 ccctcatggg accgctcgcc gatcctgacg gtttttggta tcagtgctgg tatatcattg 892381 agcagggcgg ctggactgtt tttaaccaaa tgccgctctt attcgccatt ggcatcccgg 892441 ttgctttggc gaagaaagct caggcacgcg cctgtttgga agcgcttact gtctacctga 892501 cattcaacta ttttgtcagc gcgatattga cggtatgggg aggagcattt ggcgtcgaca 892561 tgaatcaaga ggtcggcgga acgagcgggt taacgatgat tgcgggcata aaaacgctcg 892621 ataccaacat catcggagcc atctttattt cttcgattgt cgtctttttg cataatcgct 892681 attttgataa aaaactgccc gattttctcg gcatctttca aggctcaaca tatatcgtga 892741 tgatttcctt ctttattatg atcccaattg cgttggctgt gtcttatatt tggccgatgg 892801 ttcaatcggg aatcggctcg cttcaaagct tcctggttgc ttctggggcg gtgggcgttt 892861 ggatatacac gtttttggaa cggattttaa ttccgaccgg ccttcatcac tttatttaca 892921 cgccgtttat ttatggcccg gctgtagcgg aaggcgggat cgtcacgtat tgggcacagc 892981 atctcggcga atattcgcaa agcgccaaac cgctgaagga gctctttccg caaggcggat 893041 tcgcgcttca cggcaactcg aaaatcttcg gtattccggg tatcgccctg gctttttatg 893101 tgacagccaa aaaggaaaag aaaaaactcg tcgcagggct gctgattcct gtcacactga 893161 cagcgattgt cgccggtatt acagagccga ttgagtttac gttcttattc atttcacctt 893221 tcttatttgc ggttcacgcc gtgcttgccg ccacaatgtc gacagttatg tatatggccg 893281 gcgtcgtcgg aaatatggga ggcggactga ttgaggcggt aaccttgaac tggattccgc 893341 tctttggcag ccacggtatg acatatgtgt atcaaatttt gatcgggctc tcgtttacag 893401 caatttattt tttcgtcttc agatttttaa tcctcaaatt caatatcgct acaccaggac 893461 gggaaaagga tgaacagcag gaaacaaagc tatattcgaa aaaggaatac agagaacgaa 893521 aaaacaagga tgaaacggcc tccgctgctg aaacggctga tgacaccgct tttctgtata 893581 ttgaagcgct gggcggaaaa gacaacatca ctgaagtcac aaactgcgcc acccgcctca 893641 gagtcagtgt caaggatgaa acaaaggttg aacccgacag cgtattccgc gcgcttggcg 893701 cacacggcgt tgtcaggaac gggaaggcgt ttcaggtaat tatcggatta agcgtgccgc 893761 agatgcggga gcgtgtggaa aaaatattga atcaataaag actgccctcc ttttcgggag 893821 ggttttcgtt tgccgtcaaa aagaccgcca tagtaaagta aagaaagaga caatcgagta 893881 aaaaggggtt tggaggcttt tacatgcaaa aggctttgtc gtttttaaaa ccatattcat 893941 tgctggcggg aattgctctg attcttatgc tgacggagct tgcagttgaa ctgatgcagc 894001 ctttattgat tgcaaaaatc atcgacgatg ggatattgaa gcaagatctg cggcatgtat 894061 ggatatgggg cacggtcatg atcgggctga ccgtgttatc ctttgcggcg gggatgctga 894121 attcctttta tgccgcccat gtcagccaaa gcttttccta tgatacgaga aaagggcttt 894181 ttcaaaaaat ccagtccttc tcctattcca catttggaca gttttcgtcc tcttcttata 894241 ttacaaggct gacaaacgac gtcacacagg ttcaaaatat gatttttatg agtttgcggt 894301 ttatgctgcg ggctccctta atgattgcag gcggcattgt gctgtcgctt gccgttaatg 894361 tgaaactcgg gttttttctg cttgtgacca ttccgatcct gatcttgttt ttgctatggg 894421 tattaaggaa aggcggggca ctgttccgct cagtgcagaa aaggctggat caagtgaaca 894481 ccatcatgca ggaaaattta attgcaatca agctgatcaa agcgctgctt cgcggcagcc 894541 acgaagtcaa acgatttatc aaagccaaca caaggctgat ggaaaaaacg gtttcggcct 894601 ttcagcttgt ggaattcacg atgcctgtac tgatgctgct gatgaatctc tgcatccttt 894661 tgattttgtg ggcggggtcc tacagtatta cgagcggaag cactcaggtt ggcgatgttg 894721 ttgcgataat taactacgca acacgaatta caggcgcgct ttcgatgttt ccgtttttga 894781 ttatgatttt cacccgggcg aaggcttcag gggatagaat cggtgaggtg cttgaaacag 894841 aaggcgacga gcgggaggaa ggcaccatat ctgatcgttt gtcaggacgg attgagtttc 894901 agcatgtatc ctttcgctat cctgaaatgg acagagaagc gctcaggaat gtctcatttt 894961 ccgcaaagcc aagagaaacg atcgcgattc tcggtgcgac gggctcgggc aagtccacgc 895021 tttttcagct cattccgcgg ctttatcagc cggattcagg ccgcatttac atagatgaaa 895081 agccggttca agatattccg gctgaagggc tgcgcaggca aattggatat gtaccgcagg 895141 aagtcctctt gttttccggc acaatcaaag aaaacatcgc ttggggcaaa gaaaatgctt 895201 cactagatga aataatggat gcggcaaaac ttgcgcaaat tcatgaaacg attttaaagc 895261 tcccaaatgg atatgacact gttttggggc aaagaggcgt caacctgtcc ggcggccaaa 895321 agcagcggat ttccattgcg cgggcgctga ttcgaaaacc ggctatcctt ctattagatg 895381 acagcacaag cgcgcttgat ctgcaaacgg aggcgaagct gcttgaagca atcagcacat 895441 accattgcac aactttgatc attacacaaa aaataaccac ggcgatgaaa gctgatcaga 895501 ttttgctgct tgaggacggc gaactgattg aaaaaggcac tcacagtgag ctgctttctg 895561 aatctcagtt atacaagcgc atttacgagt cacaattcgg aagggagggg agcgagtcat 895621 gctaaaagac atccgcaagc ctttccaata tcccaaactg ccaattgaca aaaaagaagg 895681 cgcgaaaaag cgggcgaaag caaaggatac aaagggcaca ctgagacgaa tctggtctta 895741 cttggctgaa agaaaaggac tgctcatact tgtcatgcta atggttgtca tcagcgccat 895801 attcggactc cttggtccct ttgtgatcgg aaaggccatc gaccatttta tcgtcgggaa 895861 aacggtcagc ggcttgattc ctgttttgct tcttctgctc gctatctata tcattcagtc 895921 cctgtcgctt tggtttcaaa actattggat gattacgatc tcgcagggca cggttttcag 895981 aatgagaagc gaattgttca cccatctgca tgagctgccg attccatttt ttgataaaca 896041 gcggcacggc gagctgatga gccgggtgac gaatgacatc gaaaatgtca gttctacctt 896101 aaacacgtca gtcattcaaa ttttgtcaag tgtgatcacc tttgtcggga cgattgcggt 896161 gatgctgtac atgagcccgc tccttacttt gattacgctg accattattc cggtgatggc 896221 agcgagcctg aaatggatca ccaaccgaac gggaaagctg tttaaagaac agcagaaaaa 896281 ccttggtgat ctgaatgggt atattgagga atctgtttca ggcgcaaagg tcatcaaagc 896341 atattcacgt gagaagcaga ttactgctga attcctcgaa aaaaacgctg cactcaagac 896401 gtcgggcttt tgggcgcaga cgatttccgg gtttattccg aaggtcatga actctttgaa 896461 taacttaagc tttacaatga ttgcggcaat cggcggtttg tttgcgctga aaggctggat 896521 ctcgatcggc tccatcgttg tctttgccga gtattcaaga caatttacac gccctttaaa 896581 cgatctggcc aaccagttta atacgatgct gtccgcaatc gccggcgctg aacgggtgtt 896641 tgacgtgctt gatgaaaaag aagagcgcga ggatgaaaag aacgccgtgc atcagcccat 896701 ccaaacaggc agcattgaat tccgggatgt gtccttcggt tacgataaag ggcagcagac 896761 actgaagcat ttacagttta ccgtgcctgc ggggcagtcc atcgcgtttg taggaccgac 896821 gggggcgggg aagacaaccg tcactaacct tctcgcccgt ttttacgagc ctaacgatgg 896881 aaaaatttta atcgatggta cagatattaa aacccttact agagcaagcc taagaaaaaa 896941 catggggttt gttcttcagg attctttctt atttcaggga acgatcagag aaaacattcg 897001 ctacggcagg cttgatgctt ctgatcagga agtcgaagcc gctgcaaaaa cagcgaatgc 897061 ccatagtttt attgaaaggc tgccaaaagg gtatgacacc gtactgacgc aaaacggttc 897121 gggcatcagt caagggcaga agcagttgat ttctatagcg agggcggtgc ttgccgatcc 897181 ggttcttctc attttggatg aagcgacaag caacattgat accgttacag aagtcaacat 897241 tcaagaagcg ctcgcccgtt taatggaagg aagaacaagc gtcatcattg cccacaggct 897301 gaacaccatt caaagagcgg accagattgt ggtgctaaaa aacggtgaaa tgattgaaaa 897361 aggcagccat gacgagctga ttcggcaaaa aggattttac agtgacttat atgaaagcca 897421 atttgagaaa tagacctttg tcctgcacag aggtcttttt ttgttacagt tttatagtac 897481 ttttatttca ttttcgtaaa atgtaacaaa attacttgac gtaaacaagt tatgtatata 897541 tactagctta cattaagtaa gtgataacat ttatcaagga ggataaaatg aataaatcat 897601 ttgaaattgg cacattactt ttaagagtta ttacaggtat tatctttttt gttcacggtt 897661 tatcaaagtt tcagggaatg gagggcacca tccaattttt cggcagcata ggccttccaa 897721 gctttatggc gtatgtcatc gcagcgattg aactgattgg cggagtgctt gtcttcttcg 897781 gattggctac acgtattgtc ggtgtactgt tcgctcttac actgatcggc gccatcatca 897841 ctgttaagct gaaagcgcca ttcatgggca atgcagaatt tgattacctt ctgcttttga 897901 catccattca cctggcgctt actggaagtc gattcctggc gctggaccca tttgtgttta 897961 aaggaaaaaa gaacggaaac gtttcagcat aagaaaagag gcatgcagca tgaccagcat 898021 tcatgaggat acacacattg gctatgccaa actcacaatt cgcagtctgg agcgttcgct 898081 tcagttctac tgtaacgtca tcggttttca agtcttaaaa aagacggacc gccaagcgga 898141 attaacggct gacgggaaac gcgtactgct tattcttgaa gaaaatccga gcgctgtcgt 898201 cttgcctgaa cggtctgtga caggccttta tcactttgcg attcttcttc cggacaggaa 898261 agaacttggg atcgcgctcg cccgcctgat tgaacacggc attgctatcg gacatggaga 898321 ccatgctgtc agcgaagcgc tctacctgtc tgatcctgac ggaaacggca ttgaaatgta 898381 cgctgaccgc ccccgcagca cgtggcagcg tgatcgggaa ggaaactacg tcatgacgac 898441 aaccgctgtt gacattgagg gccttctgga agaggcagga gatgagcgga aaacatcgct 898501 tccgaacgat acaatcatcg gacacattca tctgcatgtc agtgatttga aagaagcaaa 898561 ggcgttttat acagatgtac tgggctttga cattgtcgga aactatgcgg gcatgtccgc 898621 cctcttcgtt tcagccgggg ggtaccacca tcatatcggc ttaaacattt gggcgggaag 898681 aaatgcgccg cctaaaccga caaatgccag cggactagat tattatactg ttgtcctgcc 898741 ccaccaagag gagctggatt tggtggcaaa ccgagtcaaa catgccgggt attcgattga 898801 agagacggaa aacagctttc gtgtgaaaga ccctgtttcc ggcgcctata ttacatttgt 898861 gatttaactg caatcccctt gccgaaataa cggcaggggg attttttatt tttgtccgcc 898921 ttgttatgat gagagaacca acttgttagg aggcgtttac atggaactca accaccttgt 898981 gacgggcaaa atagcattaa atcaatatgt gcatcgctta gagcaaaagg atgtttcatt 899041 ttacgtccac tactggggag cgatgacgaa ccactataac acactgcttc ataagcattc 899101 cttttatgaa atttgttacg tggtaagagg tgaaggatat taccttgaag gcgatcgtac 899161 atatccgctt cgtgaacaga cgattttttt gtcaaagccg gagcatttgc accaaatcaa 899221 aagtgaaaca gggctgttcc ttttttacgt cgctttcgag ctgagcgagg atcagtcaag 899281 cgccgaatgg atcaaagtga tggaagaagt gaaacaaagc ccctttatca caatgcaatt 899341 gaaagatggc gaaccgccgg gcctgctttg gaaaacgtta atgctgcaag cagcgcaacc 899401 tgtcaatgct tttgacaaag agatcctatc tcatttgtcg catgcattga tcctgtcatt 899461 aatccaaacc tttctcccgt acgcccaacg cccgaaacaa aagcagccca ttcacacatc 899521 ttctgctttg ctgacagagg tgaaactgca cataaaagac aatctgtcac agccgttaaa 899581 gctgacggat gtcgctagcc actttcatat ctcagggagg catttatcac gtttatttgc 899641 agcagaactg ggcgtcagct actcagaatt tgtccaaaat gaaaaaataa acaaagctgc 899701 cgaactgctg aaatcaacga atttgtcgat taaagaaata gcggaagaaa tcggtttctc 899761 agtacattat ttcactcgcg tcttttccgc taaaatcggc agctctccag ggcttttccg 899821 ctccctttat aaagactcaa aaatgaccgc atttcaaatc aataaacctt ttcaaaaaat 899881 cgaacaggcc aagccgcacg aataagatgt cctgaaatga caaaacaatg tcttcatatg 899941 ataaagacgc gagaaatctc gttgtcttat aatcttttta gaaagcggtt acaacaaggg 900001 gtattgctga aggagggatg cattggctta tgcttggtgt cgggtgctct gccattcttg 900061 aaagaagggg aagaaagccg tgagtacaaa aaagaaagag gctgtaatag gaaaagaaag 900121 cttagctcat aaagggcttt tacgaacgat tacattggta tctacattcg gcggcctgtt 900181 gttcggttat gatacgggtg tcattaatgg ggcacttcct tttatggcaa ctgcaggtca 900241 gctgaatctt acacctgtta cagaaggact ggttgcgagt tccctgcttc tcggggcagc 900301 cttcggggcg atgtttggag gacgtctgtc cgatcggcac ggccgccgaa aaacgatcct 900361 ttatttagcc ttactcttca tcgcagccac acttggctgt accttttcac caaacgcgtc 900421 cgtgatgatt gcctttcgtt ttctgcttgg actggcggtt ggctgcgctt ctgtaacggt 900481 tccaaccttt ttagcggaaa tttcgccggc agaacgcagg ggacgaatcg tgacacaaaa 900541 tgaactgatg atcgtaattg gccagcttct ggcatacacc tttaacgcca ttattggcag 900601 cacaatgggg gagagcgcaa atgtatggcg gtatatgctg gtcatcgcga cacttccggc 900661 tgttgtgtta tggttcggaa tgctcatcgt gcctgaaagc ccgcgctggc tggcagctaa 900721 aggcagaatg ggtgacgccc tgcgggtgct tcggcaaatc cgtgaagaca gtcaggcaca 900781 gcaggaaata aaagaaatca aacatgcgat tgagggcaca gcaaaaaagg ccggctttca 900841 tgattttcaa gagccgtgga taaggcgcat tctattcatt gggattggaa tcgccatcgt 900901 acagcaaatt accggtgtca attcgattat gtactatggg acagaaattc tgagagaagc 900961 cggttttcaa acagaagctg cattaatcgg caatattgca aacggtgtta tttcagttat 901021 tgcggtcatt tttgggatat ggcttctcgg caaagtccgt cgccggccca tgctgatcat 901081 cggacagatt ggcacgatga cagcccttct gctgatcggg attttatcca ttgtccttga 901141 aggaacaccc gccctgccgt atgttgtgct gagtttgacc attttgtttc ttgcgtttca 901201 gcagactgcc atttctacgg tgacgtggct gatgctctcg gaaatctttc ctatgcatgt 901261 gcgggggctt ggcatgggga tcagcacctt ctgcttgtgg acagctaact ttctcattgg 901321 attcaccttt cccattttgc tcaatcatat tgggatgtcg gcgacatttt ttatctttgt 901381 cgctatgaat atcctagcga ttctatttgt gaaaaaatat gtgcctgaga caaaagggcg 901441 gtcacttgaa cagcttgagc attcctttcg ccagtatggc cgccgcgctg atcaggaaat 901501 ccaaaatcaa acaactcact tatcgtaacc tgagatacca ggaggaatct atcaatgaaa 901561 ctatcttatg taacagacag cctagggcat ttgccttttg aagacatgct caattttgcc 901621 gcaaagcttg ggatcgatac acttgaaatg acaaccgggg gctggtcgcc ggcacctcac 901681 ttgaatcttg atgaattgct gcaaagcagc gaaaaaagaa aagaattttc acaagcgctg 901741 gaaaagcgga acatgacact ttgcgcatta aactgctcgg ggaacccttt agatccgggt 901801 gaattgggca aatcgcacag agacataact gacaaaacga tggagctggc tggattatta 901861 ggcgtcaaaa aagtgatcat gatgagcggt ttgccagccg gcggcccgga cgacaaagtg 901921 ccgaactgga tcacatacac agtaagctgg cctcccgttt taaaagatat cctcaactat 901981 caatgggaag acgttgcgat cccatattgg aagaagcttg tcaaaaaagc ggaggcctgc 902041 ggcgtgggga aaatagcgct tgagaacttc agctctcaat tagtctataa tcctgagact 902101 ctctttcggc tcagaaatgc agtcggcccg atggtcggtt tgaatcttga cccgagccat 902161 ttgttatgga tgggcgcaga cccgatcatc gcagcaaggg agctcggctc agccattcac 902221 catgtccatg ggaaagatgt cagaattgaa agatatttat cggcggtcaa cggactttta 902281 gaaacaaaag aagtgacaga tcctgcaaac cgggcgtgga attacgtagc tgtcggctgt 902341 ggacaggatt tacagtggtg gaaggaattt ttttcagttg taaaaatgat gggatatgaa 902401 ggtgaggttt ctttagaaat ggaggatctg acgatgtcac ctgaagcggg catccgtact 902461 tctgtagaag ctttaaaaca aaccatcagc caataggagg ttttcatgat gctaaatgga 902521 gaaagaatca tctctaagcc gcttcgctgg gcaatggtag gcggcgggcg gctcagccag 902581 gttggatata aacatcgtat tggagcgctg agagacaata ctgcttttca attaactgct 902641 ggcgcttttg atatcgatgc cgaaagagga aaagatttcg gggtgaacct tggagtggat 902701 gcggaacgct gttatcccaa ctatcaaacc atgtttgccg aggaagcgaa aagacaggat 902761 ggcatagagg tagtatcgat tgccactccg aacggcactc attatgagat ttgtaaggcg 902821 gcgcttgaag caggagtgca tgtcatctgt gaaaaaccgc tgttcttcac ttcagcagag 902881 gggcaggaaa tcaaagcgct cgcagagaaa aaagggaaaa ttgtcggcgt gacgtacggt 902941 ttttcaggca atcaaatgct tcttcaaatg cgtgcgatga ttgaacaagg aatgatcggc 903001 gatattcgcg tggttgactt gcagtacaca cacggttttt gtgcaacaga tgaaggtgaa 903061 aagataagcg ctgcacagaa atggcgtgtc gaccctgcga tcgccgggcc aagctttgtg 903121 ctgggcgatt tatctaccca cacgtattat atgtcacagc ttattatgcc aaagatgaaa 903181 attaaggagc tgctgtgtga ccgacagagc ttcgtcggca gccgcgcacc gctagaggat 903241 aatgcccatg tgctgatgca ttatgaaaat ggagcggtcg gaacgatgtg gacatcgtca 903301 atcaatgccg gatgtatgga tggccataga atccggattg tcggctcaaa ggcaagcatt 903361 gagtggtggg acagcaagcc aaatgaactg acgtatgaag tgcagggaga gccgggccag 903421 acactcgttc gcggcatgcc gtatttagat gatgtttgca acgccgatga acgactgggc 903481 gccttacaca gcgaagggct gtccgaagca tgggccaata tttatcttaa atttgccatt 903541 gcgatagacg ccaaaaaccg tgaagatgaa gaaatcttga acaacttggt ttatcctgac 903601 attgatgcag ggatcgaggg cattcgctgg attgagaact gcgtgcgctc ggcaaaccaa 903661 gggtcagttt gggttgaatt taaataaatg agggaatgcg ccgcatatga cataaagttc 903721 atatgcggtt tttattttcc agaaactcct gtcaaaaatg ccctgaggca ggtatgataa 903781 gaagggaatt gggtatcggg agtgatgagc gtgaaagctc ttttttttac gagaatgttc 903841 accttgatgg tgagctgttt aatgtatctg tccattgtga aagaggataa ctggtttgga 903901 tatgtattta tagcagcagg tgctgccatg tatgcagcca atcatgtttt gctgacaaaa 903961 gagacaaatg ccatctggtt ctgcctgatt gatattgcaa tcggcttttc gttcggattt 904021 atctttcccg gcacaggttt gttcattatt atgctttgtc cggttgcggt cgcctttttt 904081 ctgcgggggt ttcctaaaag aacagcatgg tctgtcttat gtctttcctc tattttattt 904141 ttgaccgtcc tcatccgtac atatgcgatg ttcggcaatg aatttgtcat tgatcatttg 904201 actagcatga cattcgttgt cttctgcggt gtcgtgggca aattaatccg caagctgttg 904261 gatgcgcagg atacggcaaa acagcagttt caggaactga cggagtccca tctggcgctg 904321 tctgctgcac atcaggagct ccatttatat gcgaagcagg ttgaagagct gactgccatt 904381 tacgagcgga acagaatggc gcgtgaaatc catgatacag tggggcataa aatgacggcc 904441 cttctcgtcc agctgcagct tttgcgtgaa tggcaaaaaa gagacagcca aaaagcggat 904501 gagacagtag gtgtctgtga aacacttgcc cgtgaagcgc ttgatgatgt ccgcttatca 904561 gtacgcactc tgcaaactga aaacgatcct tcgctaatcg aatcgctgaa acagctgaca 904621 gaggactttt gcaaaaatgc aggagtcaca acagaatttg cggtcagcgg tgatcctgca 904681 atcatcccgc tgtctctcca tccgaccctg atcagaacgg tgcaggaagc actgaccaat 904741 gccaaacggc acggcggcgc cgcagcctgt tcgatacagc ttgcctgcac aacggacagc 904801 atcagccttg tcattaagga tgacggcaaa ggcaatcctg aggcagcact tggttttggt 904861 ctcttgaata tgaaaaagcg ggcagcggag catggcggaa tgatccgctt tgaaagcgaa 904921 cgggatcaag gatttactgt aaatgcagaa ttttcacttg ccaataaaaa atggagcttc 904981 gggcccgtgc agcaaaagga gagtttatca tgattaagat catcattacc gacgatcagg 905041 atatcgtcag agaagggctg gcatccctgc tccagctccg agaagagctc gatgtgatcg 905101 caacggcgcg aaacggacag gaagccttcg aaaaggcgaa agagctggag ccggatatcg 905161 tgttaatgga catccgcatg ccggtttcca acggggtgga gggaacaaaa ttaatcacaa 905221 gctcgctgcc aagcgtaaag gttttgatgc tgacaacctt taaggattca gcgctgattg 905281 ctgaagcgct tgaagaggga gcaagcgggt atctgctgaa ggatatgtct gcagatacga 905341 ttgtaaaagc agtgatgact gttcattctg gcggaatggt gcttccgccg gaattgactg 905401 cccaaatgct gaatgaatgg aagcgtgaaa aacagctgaa aggaataaat gagatagaaa 905461 aacctaacga gctgctcgac ctgaccgagc gcgaaatcga agttctggct gagctgggat 905521 acgggctgaa taacaaagaa attgccgaaa agctttacat tacagaaggc acagtcaaaa 905581 accacgtttc aaatattatc agcaagctgg ctgtcaggga cagaacccaa gccgccattt 905641 actcggtcag atatggtgta tctgtctttt gacatatgac gttttgcata tacgcttctc 905701 tgaaaaggcc ttttacaggc ctttttttca tgccctatgt tctatctgcc gctacatgcc 905761 gcacgccttt ctttcttcta caatggcaat ggatcaaaaa aaggagtgag acgacgtgct 905821 gcaagcagaa aacatcaaaa aggcatacgg aaaaaaaaca atcgtgaaag gcatttcttt 905881 ttccctcaaa aagggggagt cgttcggtct gctcgggcct aacggtgcgg ggaaatccac 905941 aaccatctcg atgatttccg gccttgtgcc gcatgacagc gggaacatca cggtgggcgg 906001 ctatgttatc ggaaaagaaa cggccaaagc gaaacaaaaa atcggcattg ttccgcagga 906061 aattgcatta tatccgacgc tgacggctca tgagaatctt atgttttggg ggaaaatgta 906121 cggacttacg cacggtgagg ccaaaaaaag agcggctgag gtccttgaat atgtcggtct 906181 gactgagcgg gctaaagata agattgaaac attttccggg gggatgaaac gaagaatcaa 906241 catcggtgcg gctttaatgc ataagcccga gctgctgatt atggatgaac cgactgtcgg 906301 tattgaccct caatcgagaa atcacatttt agaaacggtc aaacagctca acgaaacggg 906361 catgacggtg atctatacga gtcattacat ggaagaagtt gagtttttat gcgaccggat 906421 cgggataatt gatcaggggg aaatgattgc gattggcaca aaaactgatt tgtgcagccg 906481 ccttgggggc gataccatca ttcagctcac ggtcagcggg atcaatgaag cgtttcttgt 906541 ggcgatccga tctctggccc atgtgaatga tgtaacagta catgaattag agctcaaaat 906601 tgacatttct gcggctcatc atgagaaagt cgtcacaagc ctgcttgctg aagccactgc 906661 tcatcatata aacctgctgt ctcttcaggt gcaggaaccg aatctggagc gcctgtttct 906721 gaatctgacc ggccgcacgt tgcgggattg aggagggacg gcaatgaaaa aaagcatatg 906781 gatcgcatgg aaagatgtga aaatcagaat cacggacaga aaagggttta tgatgcttat 906841 cctaatgccg ctcatcctaa cctgtatttt aggcgcagcg ctcggatcag ttgttgacgg 906901 aggcagccgg attgatgata tcaaagtcgg ctacattcaa tcagaccagt cagatacagc 906961 aaacatgttt acaaaagatg ttctcaaaaa aatgaagtcg ataaaggtca caaaagtcgg 907021 cagcaaagac aagatgaaaa aactgattga tgaaaagaaa atcgatgtag gcatcgttat 907081 cccgaaccat tgggaagccg gcaaaacctc agctgttgtt aatgccgctc ctgatcaaac 907141 attgaaaagt tccatcattg aaacagctgc aagctcattt atagagcaat ataaagcggt 907201 aaaggaagcc gcgtcaggct caatggacta catcagtaaa acggaagctg taaagcaagg 907261 aaaacttgac cctgcacagt ttgcagaaaa gctggcaaag acgctagaaa aagaaacagg 907321 tgacaagctt actattgcgg aaaaatctgt cggcagcaaa gccgttacca gttttcaata 907381 ctattcggcg gcaatgcttt gcatgtttat gctgtttcat atcacagtcg gggcgaaatc 907441 atttttacag gaaaaggata cggagacgct tgccagaatg ctgatgacgc ctgcgcaaaa 907501 atccgtcatt ctcttcggaa aatggcttgg gacgtatctg tttgccatca tacaattttt 907561 catatttctg atcgtcacaa tcaacgtatt tggtgtggac tggggcggta atctgctgtt 907621 agtgagtgta ctcgggcttt cttacgccgc agctgtatct ggtatttcaa tgctgcttgc 907681 gtcgtgcatc agcgatatga aaactgcaga tgcgataggc ggcttcggca ttcaattgct 907741 tgcggttctc ggcgggtcca tgctgccgct gtaccaattt ccggacgtct tgcagtctgt 907801 atccaaagcg gtgccaaatc gctgggcgct tgacggcttt ctttctttaa tggaaggggg 907861 aggctgggct gaccttcaaa agcctgtgct tctttttgcg gcgatcggct tttgttcact 907921 tgtaattggt atcagacggc ttcatacaag ataaggaggt acaaaaggtg aaaaaaattc 907981 tagccatttg cggcattgag ctttctctca tttttaagaa gccacagaac tatttgatca 908041 tgtttgctgc cccgcttttg cttacctttg tatttgggag tatgctcagc ggcaatgatg 908101 ataaggtgcg gcttgcaatc gttgatcagg acgatacgat tctctcacag cattatattc 908161 ggcagctgaa ggcacacgat gatatgtatg tattcgaaaa catgtctgaa agcaaagcgt 908221 cagaaaagct gaaacaaaag aaaattgccg ggatcatcgt catttcccgc tcgttccaga 908281 cacagctgga aaaaggcaaa catcctgagc tgattttccg tcacggccct gagctgtcgg 908341 aagcgccgat ggtcaaacaa tatgcagaaa gcgcattggc aacgctcaat attcaggtga 908401 ccgcggcaaa aacggcatct cagacagcgg gagagaactg gaaggcggcg tataaaacgg 908461 ttttcgccaa aaaacatgaa gatatagttc cggctgtaac acgacagacg ctcagtgata 908521 aaaaagaggg tgcggaagca agtgacacag cctccagagc agcagggttt tccatcctgt 908581 ttgtcatgct gaccatgatg ggagcggctg gaaccatttt agaagcaaga aaaaacggcg 908641 tatggtccag attgcttaca gcctctgtca gccgagccga aatcggtgct gggtatgtgc 908701 tgtccttctt tgtcattggc tggattcaat ttggaatatt gcttctttcc acccattggc 908761 tgtttggcat caactggggg aatccggctg cagttattgt attagtgtca ctttttctat 908821 tgaccgttgt cggcattgga ttgatgattg cggccaacgt cagaacgcca gaacagcagc 908881 ttgcgttcgg caacttgttt gtcatcgcaa catgtatggt gagcgggatg tattggccga 908941 tcgacattga accgaaattt atgcaatcca tcgctgaatt tcttccgcaa aagtgggcga 909001 tgagcgggtt gacagagatt atcgctaacg gtgcccgcgt cacagatatt ctcggaatct 909061 gcggcatttt gcttgcattt gctgcgatca ctttcgcagc ggggctgaaa gcgctccgag 909121 cctaaaaaac atctgccgtt taggcagatg tttttttgca tgtgggtaca ttcgtatggg 909181 tgcagcctga actgcggtta atccttatct atcatagcta aaattgattc cagccaagaa 909241 acgtaatttt tctcccgctc cagcgctttc gttagcacaa gatagtggcc gaagtccggt 909301 gaagaaaatg acatcggctc tgctgaagcc ataagctttt catagcttcc ctgtaagtca 909361 gaaagcttgg cctggcgttt ttgcagctgg tctttgaaca aatcagaagc ctcctggcgc 909421 gatagacaag aaatgaaata agccttcagc ataaattcat ccttcaccgt ctcgggtatc 909481 ggctggtggc ggatcagcca gtcatgcagc tcctgctttc cgctgtctgt cagggtgtac 909541 atctttttct ccagctttgt gccctgaatc gttgtccgga acgtgataaa tccttcatcc 909601 gtcagctttt tgagctcagg gtaaatctgg ctgtgcttgg cgctccaaaa ctggccgagc 909661 tcctctttaa aataactcgt aatatcgtat ccactcaatt cgccttttcg caaaagccct 909721 aatatggcgt attttaatac tctcatgcta tcctccgtgt ctggctgttt cgcaaaacag 909781 atgagccggt gctcaactgt gattctaact gcctattccc cttattatag aaaagggagg 909841 aagggaacac aaccgggctc tttggaaatg aagataaaag gtttgtcaga aggtatccga 909901 tttatctccg tcaatataaa agagatttaa atttaatttt cagaaaaaat agtaacgata 909961 ttgatttttt atatataata ggaaattggt ggtatgaaaa ttttttgggg gaataaacgt 910021 gaaaaaagta cttatggcat tcattatttg tttatcgctg attctatctg ttttagccgc 910081 tccgccgtct ggcgcaaaag ctgagtcagt acataatcct gtcgttcttg ttcatggaat 910141 aagtggtgca tcatacaact ttttcgctat taaaaactac ttaatttctc aaggctggca 910201 aagcaacaaa ctgtacgcaa ttgattttta tgataaaaca ggaaacaacc taaataacgg 910261 cccgcagctt gcttcatatg ttgaccgtgt tttaaaagag actggggcaa aaaaagtaga 910321 tattgtggct catagtatgg gaggcgccaa tacgctgtac tatattaaat atttaggcgg 910381 gggcaataag attcaaaatg tcgtaacgct tggaggggct aatggtttag tgtcatcaac 910441 cgcgctgccg ggcacagacc ctaatcaaaa gatcctctat acatctattt acagtctcaa 910501 tgatcaaatt gtcatcaata gcttgtctcg gttacaagga gcgcgaaaca tccagcttta 910561 tggcatcggt catattggct tgctttctaa tagccaagtg aacggctata tcaaagaagg 910621 gctgaatggc ggaggcctca atacaaatta atatcttcaa aaaacaacct gctgtctccg 910681 ttacagtggg ttttttcgtc tgagaaagcc atagggtctt atgaccttag tctatcatgc 910741 atacgtcaat ttatgacatc aggcactttt tcaaatagag cggacatgtt aaggtacaac 910801 catcgatttc tatcaatttg aaataaaagg agcgctgtta tgcaaattaa agaaattttt 910861 atgatccgct gcatttcgtg cttaagtgtc gtcttgctcc atatcatttc aatggtcctg 910921 atgcttcagg cagaagctct tgcagatatt tctcacactg ttgattcttt ccgcacactc 910981 ctgatgttca gcacgcccgc ttttattttc atctctgaat ttttactggc ccgttcttat 911041 cctgatgggg tgcctgacgg ttttttaaag aagcggggaa aagtgatttt tgttcctttt 911101 ttatttatcg cagccatcga tgcgctgctg atgaccagtg cgatgggggg agaggtaacc 911161 tttctcgcgt ttgtgcaaaa atatctggcg aacgtattct taggaaactt tatcggatac 911221 ttcattctcg tcatctttca attttacatg ctgcatatga tgtttcatga gtatttgaaa 911281 aaagcatcgc cgaaatgggt gctgtctatc tcatttgtgg tgacagccgc ttatttaggc 911341 tatttctccg cagccagccc ggctcctgct tctgaagagg gaggggcatt tccgttcttc 911401 tgggttccgt tcgcaggctg gcttttctac ttttgtctag cctactattg cggaaaagaa 911461 tacaagcgtt ttttagcgct gctgaaccaa taccgctggg tggtgtacgg cgccgcaatt 911521 gcttctgggg cgctggttgt cactgtttct tatgtcggtg aaatcggcat gatcagctcg 911581 aagcggcctg atatcatgct gtattcaaca agcatgattt tcctgtgttt tcatttgttt 911641 tccaaaatga agcatgtgcc gaaaatcatg atgtttatca gcaactattc cttttcgatt 911701 tatctgcttc atgcctattt tatgattata ggctacgtgt tgcttttgaa tatgcccgaa 911761 attcctgccg taccggctgt tctcctgttg tttgccgtgt gcacagccgg cccgattatg 911821 acctcatggg cgctgaataa gttcaaatac gggtatttat ttgtggggaa aatttatcag 911881 ccaaaacaga agaaggtaac agtcgaagtg cgtgatcacg cagggtgaaa aacaagcggc 911941 aggagggctc ctgccgcgtt tctttacttc tcatccgctt gcagaactgt ttttaaatat 912001 agttttgcag actcagcaag tccagataca tcagcctttt cttcatcgaa atacagggcg 912061 ttttgaatga tgccgtcatt catattgagg aaaaacttgg cgatagtcgc aagaggctga 912121 accggctgaa actctccctg atcgatccct ttttgcaata gccttgaaaa cctttccaca 912181 aaaagatcat accttttctc caaatactgc cgccgttctt cattgcgcca agctgtcact 912241 aaatattcaa attgcaccgg cgccagcgta tctgctacat ctcgcaggcc ctcagtcagt 912301 tcatccaaat agctggaaat ggaggcccaa acactttggt gttcagctga tttatcaagc 912361 tttcggagtc cttcatccag ccctgtttca ataatgcggc gaaacatctc ctcagtgctt 912421 gaaaaataaa gatagacacc gccccggctg aaacctgact cttctacaac atccttcatc 912481 gtcgttaatt cgaatccttt tcgtttaaaa accgttttgg cagcctctaa aatctctgcc 912541 tgccgtttat ccttgtgctc ctttgttact tttggtgaca agatatcgcc tgctttctgc 912601 aattttctta cctataagtg taatcaaccc aatcatgatc agcaagcagc cacagacaag 912661 aaaagcaagt gatacaccga tccattccgc cagcacgccc ccgcccgcca tgccgaggat 912721 agaggcgagg gttgtcgcac tctgaatagc gccgaacacc ctaccgctgt aatcgacagg 912781 cactgttgtt tgcacgagaa tctgaaatgg aatatggacg aggccgaaag ccgcccccat 912841 gatgaaaaaa gcaaatataa agagagtgat gccggcaatt cccataccgc ttaggaatgg 912901 cgcacctcca gttgctagtc caagaagaag ggttccagct gagaaataaa gcaaataaga 912961 agtgattcgc cgtctgccgg taatggccgc tgtaaggagc atcccggctc cgcttacggc 913021 catgcaccag cctgccagct cgggcggagc tcctgaaaag gagcggataa gaataatcgc 913081 ttgggaatca ccaatctgca aaacaaagag aacgacacaa gctgttagta agcctgttaa 913141 tagaagcggc atccgtttca aaaactgaag gccttccttg atagaagtaa gtgctgctgt 913201 tttttcttga ggtgtattgg ctttttgtaa aaaagcatct ctgggaagga aaaacaaaat 913261 gacagcggaa agaaagaagg cgccggcgtt tatataaaaa acagagtgta tcgagaaagc 913321 agcgatcagc gtgccgccaa gggcagggcc gaagattttt gagctgttat caatgatgct 913381 gctgacggaa acggcctgct gaatgtgtgc ttccggagcc aattccttaa gctttccgtt 913441 tttagcaggt aaaaaaagtg aagaaaaaca gctctgaacg gatagcaata cgtaaagctg 913501 ccaaagctca ctgacataaa cgcagctgat aacagtgagg gcacggccga tttcagatag 913561 aaacatgatc gtttttctgt caaaacggtc ggcaagcaga cccgatacag gtccgagtac 913621 aatgacaggc aaagcaaacg acatcattaa aagcgacata tctaatggag aagcatgaag 913681 ctgaaaagcg gctaatgtta gcacggccaa aatgtgaagc cagtctccaa gtgaagaaat 913741 ggtttgcgag gctaacagtg tcatcagtcc tttttgattg cgaaacaacg gtttttccat 913801 gattcatcct cctgattatt aaaatgacac tagtgtcgtt tttaattgta tgggaaaaag 913861 acacaatata caatcttttt cttgtaaaat aaaggagaag attgaataga agggagaaca 913921 ttcatgacat cagtcaatct aagctaccca ataggagaat acaagccgag ggaatccata 913981 tcgaaggagc aaaaagataa atggattcaa gtacttgaag aagtgccggc aaaattgaag 914041 caagctgtag aggtcatgac ggacagccag cttgacacac cgtaccggga cggtggatgg 914101 accgttcggc aagttgttca tcatctggct gacagtcata tgaacagcta tattcgtttt 914161 aaattgagct tgacggaaga gacaccggct atccgtccgt atgatgaaaa agcatggtcg 914221 gagctaaaag actcgaaaac ggcagatccg agcggctcac tcgcgctttt gcaggagctt 914281 cacggaagat ggacggctct gctccgcacc ctgacggatc agcaatttaa gcgcggattt 914341 tatcaccctg atacaaagga gatcattacc ctggagaacg cgctcggcct gtatgtctgg 914401 cactcacatc accatatcgc tcatattacg gagctttcca gacggatggg gtggtcttaa 914461 cgcttttgcc ggcggaaagc cggaatactg atagcagcaa tcaccagaag tgagaccaca 914521 gcagccgctg catataaatg atcatagccg ctggcgacac tcgcatgaat ggcgtcgctt 914581 atcgcggttt tgacttcagg aacgggaatg cgttcgattt gttcttgtaa agaagaaact 914641 tcagaactgt cgatctccgg aatcatctgc atcgcctttt ctgaatatcc gctgtccgat 914701 aagcggctgt tgatctcatc acctatttgg tcaaacccgg ctgtgataaa acctgcataa 914761 agagtaggcg ccaaggtcag tccaatttgc cttactaatg aaagcgtgcc aagagctgta 914821 cccttatttg tttttgccgc ttctgataca aggacgttca gcggagcgcc taacagaaag 914881 ccaaaaccga tcccagctgc cacacttgcg atcacaaact cccatttttc cgtgacccag 914941 agcggaaata aagcaaaccc cgcacatgag atgattcccg aaagaataac ggtttttaca 915001 ggaccttttt tgtcggtaag tgctccgcca agccaagcgc cgattccgga agccaacgca 915061 agcggtgtca tccaatagcc tgcttttgcg gcagggacac ccaaatactg ttcgacatat 915121 gacgggataa aaatgactgc cgccaagagc cccccggata acaaaccgat gataagcgtg 915181 cgctgaaaca tatggtttcg cagcagagaa tacgccaaaa tgggatcgcc tcctcgcatt 915241 tcaactctct tttcatacga gataagcgct gcaaaacaga gtatgccaaa aataatacat 915301 ccataaacct ccggattccc caagctgtgt aagagatttg ccccgtcaag attggtcatg 915361 ccgtacatca cagctaaaat cgacagggac aaaaggaaga ttccggccgc atcgaggcgc 915421 ttagcctcag gtgcttttgt ttccgcgata aaacatgcgc cgaaaacaac caatagcacg 915481 gcaatcggca aattaatcaa aaatagccaa tgccaagacc cggtccaatc aagcagaaag 915541 cttccgatat ttggcccgag cacagcggcc atcccgttca ttgcgccaag cagcccaagc 915601 gccttcccct gtttttcctt tggaagggtc gcgagaatgt gagagctgcc gatgatgaaa 915661 atcccgccgc ctccaagcgc ctgaatcagc cgcgatatca gaaagagcgg gaagctttgg 915721 ctcaaagcaa caagcaaaga accaagtccg aacaggcaaa cctcaatgag aaagagtttt 915781 tttctgccgt agcggtcgga aagttttccg acgattggca cactgacgct aagaccgagc 915841 gtataaaggg taatgcccca tgatccccag gaaggggaaa cggaaaacga ctcgtttatc 915901 gttgttaaag cagccgaaat aattccgtta tctaaagcag ccataaacac gccaatcgta 915961 aacaggctga ttgcccactt ttggcttttc tgctctgtta atgcttcaga cattttcgtc 916021 aactcctttt agttcacttg aaatatatta ttcattttaa atgaactaaa tgtcaaataa 916081 aaaaagcctg ctcccgcagt ttgcggatga cagacttact gatttattct tttttcgcat 916141 tctctaatgc tcttgaaagg atagacagcc cttcgtaaac agcctgcttt tcttcagggg 916201 acagcagctc taatgaacgc ttcaatttca ggtggccctt ttcatacaaa ccccggaaaa 916261 tctttttcgc attctctgtc aactgaacaa ctacagagcg gcggtcctct tcagaatgtg 916321 agcgtttgac aaatcctgat ttttcaagcc ggtcaagcag cccagttgta ttggacaggg 916381 aagcccccat tttttcagca atgtcgctca ctttcaatgt tccatggttg tttaatagca 916441 tcagcacctt catttgcggc atgctcatat ccagtttcat ccactcggac acatcaccga 916501 gcccggcgga cgttaagact ttcatataga gcacccatat ttcccgttcc tccgatgaaa 916561 gaatgttttc gtttaagact gttgtatcgt gtaaattata ttccatttca tcacttcctc 916621 atcattcact cctcttacca tattactcga ttttcactcc tgaaagaaag tgagcagaaa 916681 ccgcatgcgg gactttgtcc gaaaaataac ggtagtgtat aatgagttgg agattattgg 916741 gggagaggat cgaactagaa tatgattgga gagaccattg ctgattaaaa agaatgcttt 916801 atcaatatta aaaatcgttt ttcctattgc tgttttgcta tttgttattt atcaatcgaa 916861 aaaagaactg acaaatctgt cattcaaacg tacgctcatg gtcatcaacg gactggaacg 916921 aacggattta ttcatgcttg tgttgatcgg cttgctggct gttgcggcta tgtcgctgta 916981 tgattacgtc ctgaagtact cactgcgcct atcgatcaca aacggaaaag ttttcagggt 917041 ttcctggatc gccaattcat ttaataatgt gttgggattc ggcggtttag ccggagtcgg 917101 gttaagaatg atgttctata aggagcatac gaaagaccat aaggcactcg tgaaaggaat 917161 cgcctggctc acatcatcta tgctgctcgg attatctgtt ttcagcattt tcgttgctgc 917221 gagagtgctg ccagttgatg aagtgattca tgagaagcct tggctgtggg cggtcgttat 917281 cggttttgca ctgatattgc cgttatcttt agcggtgtcc aaaataaaag accgcaaagc 917341 tggggacgaa gagaatgcgg ataaagtgaa aaatccgatt ttcgcatata ttggagcttc 917401 agttgttgaa tggctcatgg ccgggaccgt catctatttt gctttgttcg ctatgggcat 917461 tcatgcagat atcaggtatg tgttcggggt gttcgtcatt gcggcgatcg gaggaatgat 917521 cagcctcgtg ccgggcggct tcggctcgtt tgacctttta tttttgctgg ggatggagca 917581 gcttggctat catcaagagg ccatcgttac ttctattgtg ttgtacaggc tcgcctactc 917641 atttatccca tttatcttgg gactgttctt tgccgccggc gacctgacgg aaaatacaat 917701 gaagcggctc gaaacgaacc cgcgcatcgc accggcaatt gagacgacaa acgttctgct 917761 tgttgttcag cgtgcggtat tagtgagaat tttgcaaggc tcgctttccc ttattgtgtt 917821 cgtagcaggt ctgattgtct tggcctcagt ttccttgccg attgacaggc tgacggttat 917881 accgcacatt ccgcgcccgg cgcttttgct gttcaacggc ctgtccttaa gctcagcgct 917941 cattctgctc attttgccga tcgagcttta taaacggaca aaacgttcct acacgatggc 918001 cattacagcg cttgtcggcg gctttgtgtt cagcttttta aaagggctta acatcagcgc 918061 gatattcgta ctgccgatga ttatcgtatt gcttgtgcta ttgaaaaaac aatttgtccg 918121 cgaacaggca tcctatacac tgggacaatt gatattcgct gtggcgctgt ttactgtggc 918181 gctctttaac tacaatctga tcgcgggctt tatttgggac cggatgaaga aggtgctgcg 918241 tcacgaatat ttcgtccaca gcacctcgca tattacacat gcaaccatca tggcgatcat 918301 cattgtgccg ctgttcttct tgatatttac agtggtctat cataagagaa cgaaaccgat 918361 cggagagaaa gctgaccctg agcgtcttgc tgcgtttctc aatgaaaaag gcggcaacgc 918421 gctgagccat cttggttttc ttggagataa gcggttttat ttttctagcg atggaaatgc 918481 actgcttctg tttgggaaaa tcgccagaag gctggtcgtg ctcggcgatc catctggcca 918541 aagagaatca ttcccgctcg tgctggaaga atttctgaac gaagcgcatc agaagggatt 918601 cagtgttttg ttctatcaaa ttgaacgaga ggacatggcg ctgtatcacg attttggcta 918661 caacttcttt aaattgggtg aggaagcata tgtagattta aatacattta ccttgactgg 918721 gaagaaaaaa gccggccttc gggcaatcaa taaccgcttt gagcgggagg agtatacttt 918781 ccatgtggat catcccccat tttctgatgc gtttttggag gagctgaagc aaatctcaga 918841 cgaatggctc ggctcgaaaa aagagaaggg attctcgctc ggattttttg atccttccta 918901 tttacagaaa gcgccgatcg cctatatgaa aaatgcagaa ggagagatcg ttgcattcgc 918961 aaatgtcatg ccgatgtacc aggaaggaga gatatcggtc gatctgatgc gctatcgcgg 919021 cgacgctcca aatggcatta tggacgcatt gtttatccgt atgtttttat gggcaaagga 919081 agagggctgt acgtcattta atatggggat ggcacccttg gccaatgtcg gcactgcctt 919141 tacatccttc tggtccgaaa ggtttgccgc tgtcattttt aataatgtca gatacatgta 919201 cagtttcagc ggcctaagag cctttaaaga aaaatataaa ccggagtggc gagggaaata 919261 cttagcgtat cggaaaaaca gatctctttc tgtcaccatg ttcctcgtta cacgtctgat 919321 tggcaaaagc aaaaaagact ccgtctaata agacggagtc tttttttatt tcgtttttaa 919381 gaagtaggtt tcaatatcat caagcaggta gtttgcggct ttaattccgc ctgcggttgt 919441 ccatacgacg tcatcgactt catgtgcatt acctgacttc acggccttca ggtttttcca 919501 tagtgaactg cttgtccact gattggccca tttttcattt tcttttgcat tatcggcttt 919561 ataagtgaaa taaaacagca catcagcatc catatcagga atagattctt tactgtcggt 919621 tgagaacgta aattggtcct tttgtttctt aaacagttcc acttgttttt cagggcgttt 919681 gaagccaagc tggtctaaaa taatcccagg aaatgaatcg gtataataga ttcttgattc 919741 accggataaa aagcgtacga ctgaaacggt tttgtttgtc tggtcgccca gcttgttttt 919801 taaatcagaa acacgtttat caaaatcggc aatgacttcc ttgcctttgt ccgccttatt 919861 caccgcgttg gcgtatagag tcaggttatc cttccagttc ccggccaaag attcagcaaa 919921 aacagtcggc gcaatcgcat ttaactgatc ataaattttt tcctggcgca ctttgtttcc 919981 aataatcaaa tcaggcttta attctgcgat ggcttccaca ttcggttccg tttcaagacc 920041 gacgttttta acacctttca tgtcatcttt cagatagtca taccacgggt cgcccttcca 920101 tgactttacg gctccgaccg gcttaatgcc aagcgctaag agcgcctctg ttccttcatt 920161 agttaaaaca acaatccgtt ttggattggc ggggatgttg tctgatgtcc ccattgcatg 920221 tttgaccgtt cttgttttgc tgcttgacac ctcgctgttg cttgaacttt ctgaactatt 920281 acaggcagaa agtaccataa cggccattaa aaatacgaat agcatgctga tatgcttttt 920341 catctttttc ctcccaatat tgaaattcat tatcatttag atcataataa gcagtgttaa 920401 gagtgtcaat ccctaattga ggattattct caaaaacaaa cattacatag taaataacta 920461 ggagaattag atcatgatct gcaaaaaggc atcttcaaaa tggattgtgt tagtatgtct 920521 gattttcatt ttactgacgg ctgtctgcgc aagcgtcgtg tatggctata caggtacgtc 920581 atggagacag gtctatcagg cgtttacttc cttcaatgga acaaatgagc atgtcatcat 920641 caaggatgtc aggcttccgc gcgctttggt tgcgacagtc gtcggcgcct cgcttgcagc 920701 cgcgggcgct ctcatgcagg cgctcacaaa aaatccgctt gcgtcaccgg ggattttcgg 920761 gattaacgcc ggtgcaggtt tttttattgt tgccggatcg ttttttctgc atattcagtc 920821 acctcaggca ttagtatgga gctcgtttct gggggcagca tttaccgctg cgatcgtcta 920881 tgcagcaggc tcgcttggga gggaagggct gacgccaatc aaactgacgc tggcgggagc 920941 tgccatggca gccatgtttt cttctctgac acagggcttg ctgtctgtca acgaactcga 921001 gcttgcccag gtgctttttt ggctgactgg ctctgtgcag ggccggagtc tggatctgtt 921061 gatgacgatg tttccatatg cagcggcagc gctggtaatc tgcttctttc tcggccaaaa 921121 aattaatctc ctcgttatgg gagaagatgt ggcaaaagga ctcggccaaa aaacaggcct 921181 gctgaaattt gtgatggcgc tttgtgttgt catgcttgca gggtccgctg tcgccattgc 921241 cgggccgatt tcttttatcg gcatcattat tccgcatttt gcccgctttg tcgttggtaa 921301 tgattatcgc tgggttctgc cattttccgc tgttttgggt gccattttgc ttgtttgcgc 921361 ggatatcggt gcgcgatata tcattatgcc tcaggaagtt cctgtcgggg tcatgaccgc 921421 catcatcgga atgcctgtgt ttgtgtacat cgcaagaagg ggggcgaagc tatgaaactt 921481 cgttttggcg ttactgcggc tgaaaagaaa gcatggatcg tctttttggt tttactgggg 921541 ttaacagctg ctgtactcat cataagcgct ggtctcggac aaaggtttat tcctccctgg 921601 gatgtagcaa aaacattctt tggtgcaggt tccaagctgg atgaactgat gatcatgtcg 921661 ttccgcatgc caagaatttt gacggcttta tgcgccggtg tctgcttggc agcggcaggc 921721 gcgatattgc aggggctcgt cagaaaccct ctcgcatctc cggatattat cggaataaca 921781 ggaggagcgg cggtagcggt cgtgctttta atgatgttct tctcagaccg cagcagttca 921841 cttacgatca gtctgtcatg gcttccagca gccgcattta tcggcgcatc ggctgtcggg 921901 ctcatcgtct atttactggc atacaaaaat ggcgcctcca catttcggct ggtgcttatc 921961 ggaatcggat tttcaatgtc ggcgcaggcg atgactaccc tgttgatgat caaaggcccg 922021 atttaccgag catcacaagc caatgtgtat atcactgggt cagtttatgg gtcaaactgg 922081 cagcatgtaa aaatagctat tatcttatct gtcattctct tattcatttg ttttgtcgcg 922141 ctaaaaaata tgaatataca ggtgctgggt gaagatattg cggcgggtgc aggaagcgct 922201 gtgcagcgaa atcgtttttt cttgctcctt ttgagtacgg ctcttactgg ttgtgcagtt 922261 tcagttgccg gcacaatcgg ttttgtcggg ctgatggcgc cccatattgc aagacggctt 922321 gtcggctcat cttatggcgc gctgctccca gcgtcggcac ttattggagc tctgctcgtt 922381 ttaacagctg atatcgtcgg cagaacctta tttgctccgg tggaagtgcc ggccggcgtc 922441 tttacagcgg ctatcggcgc accttatttt atttatttgc tctataaaac aagaaattct 922501 taatcgttac acccattttc ttaaaaaaga aaatgggttt ttttgataat gactgaagat 922561 tcgtaattat ttttgctata ctgacagaga cattgataaa gaaagggcgg cagatgaatg 922621 aaagaagcag aggtattaaa atatgaagca tttacaagca gtcccggcaa aggaaacccc 922681 gcaggcgtcg ttttgcaggg agacgattat acggaagacg agatgcagat catagctgaa 922741 cgtgccgggt attcagaaac ctcctttatc cgaaaaagcg agtcggccga tcttgaactc 922801 cgttacttta cccctggaca cgaaatgaat ttgtgcggtc atgcgacagt tgcttctctt 922861 tacgcattat gtgagaaagg aatgctggag agcggtaaaa cgtacagcat ccaaacgaaa 922921 gcgggtatcc tgcctgtgaa gatttctgaa aaagatggcc gcattcatat cacgcttgaa 922981 caggcctctc cgcaattcaa accatttaca ggcgatcgga aaaaacttgc ggacgcactg 923041 ggtatcaccg atgaagattt tcatgaagac cttccgattg tgtttggcag cactgggata 923101 tggacagcca tcgttccgct taaatcattg gaggcttcca aaaaaatggt gccagataac 923161 aaacaatttc cggaagtgtt agttgatctg ccaaaagctt cagtccatcc gtttaccttt 923221 gaaaccgtcc atcccgacag cgacctgcac gggcgccact tttcatcccc gtattcggga 923281 acgattgaag accccgtgac cggcacagca tccggcgtga tgggggctta tatgaaacat 923341 tatggcaatg ccgagcagca taaatttatc attgaacaag ggcaggaaat tggaaaagac 923401 ggaaaagtgg agatcgaaat gaacgaagcc ggcggccatg tgaaagtgaa catgacagga 923461 acagccgttt actcagaaac ccgtattctt aaaatctaat acggatgatg gtttacaaaa 923521 agatgcactt tccgttatca ttatgaaatg ataatcattt tcaattgcat aggaaggtga 923581 gacggtatgc ctcaaaccga acaaatacat cagcattcag tactgaggga catcatacgc 923641 agcagaagat cgattcgaaa gtttaaacaa gagccagtac cttcagcagt cattcttgac 923701 atgcttgaaa cggcaaaata tgcgccaaat cacagagtga cagagccatg gagatttatt 923761 tacgtttcca gtgagacagg taaagcgaac ctcattaata catttgcagc gttctctaag 923821 aaatccaagc cggatatgac agaggaaaag cttcaaaatt tcaaaaacac acttgggcgc 923881 gttccgggat ttctcctcgt cgtgtttcag gaagatgaaa acgaaagagc gcgggacgac 923941 gattttgcgg caacaagctc gttgattcaa aatcttcagc ttctcgcttg ggaaaaagga 924001 atcggcatgg tttggaaaag cggaaaaatc ctttatgaca aagaagtcca tcaggccttt 924061 ggtttacagg ataatgagcg tttcgccgcc atcatacaaa caggttatcc tgacgaggcg 924121 ccggaagtga aaaaacgcac accgatccgc gaccgattca ctgaaatgta aaaaacccct 924181 tgtctcaaac ggagacaagg ggtttttcat taacgagatt tctttttcgc tctgttgtcg 924241 gctgctttcg cacgctcttg cgcttcgcgg tcatctgcat cagcaagctc ggttgaatat 924301 tcttcgtaaa cgccgtcagt ttcccttttt aaggcatcgg gaacttgtgg aagcttttgt 924361 ttgtttttat cacggttttt gtggatatga tttctgccca tatcaaattc cccctaaaaa 924421 gtgatatcaa acaaatatag tatttggttt taaggggcta tgtattccta cttccgctta 924481 gcagcttttt ccgctttttt aaattcgcct gaataaagaa cttcctgcat ttttttcagg 924541 ttggcgcctt gctggtgctt ctccctcttt ttttccataa aaaggacctc cttcaaccat 924601 gttattctta aggttgacgc ttcctgctgt ttttatacag tctttcggtc cgctatcagc 924661 tgtgagagtg caaattcaag atccgaatat gtaaaacgaa atccagaggt tatcgctttt 924721 ttcggaagag cgcgctgtcc tttcacaatc aaaagactca tttcacccaa tgcttttgat 924781 aaaaagaatt ccgggacggg gagccagtgc gggcggtgct tcacccgtgc aatcgttttt 924841 ccgaattgct tcatgtccac aggattgggc gcggtgacat tcattgggcc tgagatgccg 924901 gcgttttcca ccgcatatcg gatcatctgg gccgcatcct cgacatgaat ccatgacagc 924961 cactgccttc ccgttccgat cgttccgccg gccagaaact tataggggag aatcatgagc 925021 gggagagcgc ctttttctcc aagcatcacg ccaaatctcg cataaactgt ccggatgccc 925081 atcgcttcaa tatgctgtcc ttccttttcc cacaggtgtg cagtatggct gagaaaatcc 925141 tcatctgacg ttgcagaatc ctctgtgaaa gttttctcaa ggcttgtgcc gtaaatgccc 925201 acggcactgg cttggatcaa tgtcttcggc ttctccttct gtttctgaat aagccgctgc 925261 acttcacgcg tcgcattgat acggctggag agaatgtgct gcttcgtttt ttctgtccag 925321 cggccaaaaa tcgattttcc cgcaagattt atccagacat caatatgagg aagttcctgc 925381 tccggtgcgg ctccttccga cagccattgg acatatgtca tatttttttg ttcagtttcc 925441 cttgcgtttc ttgataaaat ataaacatgg tgtccctggc gggtaagaac gcctgtcaga 925501 tgctggccga gaaaaccggt tccgcccgtc attgcgatat tcatgaacat ctctcctcat 925561 cgttctaata aatatacttt acctcattgt aataaaagaa aacgcgtttc aggcctgaga 925621 agggagatta agatgccgtt tattacaaaa atatcaacgc aaaaaaagaa tacggaacgc 925681 ttcaatattt ttctggatga taaatacgcc ttcagcgtgg acgcggatgt gctcgtgaaa 925741 tttgagctca agaagggaaa agaactcgat gatcttgaca tcattgagat tcaatacggc 925801 gatgaagtga agaaaggctt caaccgtgcg cttgactttt tatcctatcg aatgcggtcg 925861 acgaaagagg tcgaggatca cttaaagaaa aaagaaacct cgccccccgt cattgcggaa 925921 gtcatccata ggcttaacga ttacaagtac ttaaacgacc aggaatttgc cgcagcctat 925981 gtcagcactc acaaaaaaac aaacggaaaa ggccctgatg ttttgttcag agagctaaga 926041 gcgaagggaa ttgatgacga tacaattaag gaggcgctaa gttccttttc ctttgaagat 926101 cagacaagag aagcggtcaa gcatgttgaa aagcttctca aaaaagataa aaagctttcg 926161 acgaaagaac tcaaacagcg cgcccagctg cagcttcagc gcaagggctt ctcatttgat 926221 gttatcagcg cggcgatgga tcagattgaa tatgaaaatg atgaagacac agagaaagaa 926281 gcgctgcgcc ttcacgcgga aaaagcgttt agaaaatacc gctatgacgg ctcatatgaa 926341 agcgccatga aggtcaaaca atttttattc cgcaaaggat tctcactcga tttaatcgag 926401 caattactgc aggaagagga gtactgaaat ggagaaacga tacagtcaaa tgacaccgca 926461 tgaactcaat accgaaatcg cattactttc tgaaaaagca agaaaagccg aacagcatgg 926521 aatcataaac gaactggcag tgctcgaacg gaaaattacg atggcaaaag catatttgct 926581 gaacccggaa gattactcac cgggagaaac atatcgtgtg gaaaacactg aggacgagtt 926641 taccatcagt tatttaaatg gcgttttcgc atggggatac aggacctctt cccctcagca 926701 agaggaagcg ctgccaatct cagtattgca agaaaaagaa taaagcgtaa caggaggctg 926761 atgatcagcc tctttttgtt tgcagcacat ttacacgaat tcttaaagaa aaaatcattg 926821 aattcacttg aaaaatcttt taagatgaaa ctcgttgttt tttaaaatca aaggaggcga 926881 tgacgttgag tatcaaaaac ccatctgtaa aatttattat atttgttctt atgatttgta 926941 cattttcaat cggctataca gaatacgcgg tgatgggtat tttgacgtcg attgccaatg 927001 actttcatat acaggtttca tccgcagggc ttcttgtcac ggcttatgcg gcaagcgttt 927061 gtttgacagg gccgctcgtc accatcattt ccgtcaagct tccgagaaag cctgtgcttc 927121 ttgggctgat ggcgatattt atcctttcca acctgatgag cgcactggcg ccgaattttg 927181 cggtattggc catttcaaga attttatctg cgtccattca cggcgctttc ttcgcgattg 927241 ccatggtatt cgcaagtgaa atggttccgc cggaaaagcg tgctgcagct gctgcttcaa 927301 tgaacggcgg actgacagtg gctctaatgc ttggtgttcc attcggctct tatctcggag 927361 atgtcctgaa ttggagagcg gtgttttcca tcattacggc acttggtgtc atcggatttt 927421 taggccttat ggctgccgtg ccgaacagaa aaccaaaagt gatcccaatg cttatgaatg 927481 agtggggtgt ttttaaacac aaacaagtgc tgttttcctt cgcgattacc attttaggct 927541 attccggtgt ctttatcgcc tacaccttta tcgaacccat tttgaggcat tcagccggat 927601 tcagcacggt tggcattaca ggtgctctct ttgcgtatgg attgggaggc gttgccggga 927661 atttctttgc tggaaaggta ccgctgcctt tgctgactcg gacgatgatc ggcgtaatga 927721 tcggtttaat cggtgttctg gctgtatttc cttacatcgc catttacccg gctgcagcca 927781 ttgtggcaac gttcctattc ggggcatgcg cattcggcac gccgcctctt ctgcaaacaa 927841 aggtcatttc ctcatctgag ggcggcacaa ccattgccgc agctgtcagc gtatcagcat 927901 ttaaccttgc caatgccctt ggtgcatgga tcggcggaat gattttaaac ggaacaggct 927961 cttattcctg gctgtttgca ggaggtgcgc ttatgaccgc atgcggactt gtgctttcta 928021 ccttcgcaca cttatcagaa aagaagagcg tctacgaata tcaagtcaat aaagggtaaa 928081 aaacagctgc agtgtatgca gctgttcttc tttaccgttt gcctgaggct ctcattcttt 928141 cttgaggatg ctgattgata gatccgtcag cacgctttga agcatagtcg tcctttgctc 928201 tcggttcacc ctgaaatttg ttttcgtttt cgtaaggaaa tcctttttct ttatttcgga 928261 ccatgtcata tccccctagg ttcgagatca aaaagttgcg tcttttcaga tgaagacgta 928321 aggttagtat atggagaaca ccacgtaata aagcgttatt tttttcctga agaaaggaga 928381 ctgcacacat gaatatgtac attgagaaac tgactaatct gcttctggaa aagaacgaga 928441 tgatcagcta tatacaggca aaaacgtggg tggaattgtt atggagcgat ttcgaagcaa 928501 cctacgcaaa agccggacac gcctatcaag gtgaaaaaat gactgaaaaa atcgtcacac 928561 aatggattga aaactatggc ggccagctcc acctttttca aagctcccgt aacgacgtga 928621 atgattactt aaatcaaagc agaggccttt tgcattaaaa acctgccgtt aacgaccggc 928681 aggttttttc attttcttaa aattacctta acaggaagaa atcataaaca aaacatgttt 928741 caccagcctg tcaatcaggg aataccactt atatcttgtc aaaatgcgag gaggagcttt 928801 atatgaaaaa gaaacaagta atgctcgctt taacagctgc cgcaggactg ggtttgacag 928861 cacttcattc cgctcccgca gcaaaagctg cgccccttca cgacatatct gtcagcatgc 928921 catcatccga tacttacatc ataaaagcag gaaagctgaa tgtccggact gagccaaatc 928981 atgaaggtga tattctcggc actgtatcat cagaacaaaa ggtaaaagtc gataggttcg 929041 taaatgccga ttgggctcaa attcatttca aaggaaagaa agcatatatt tcaactcact 929101 ttttaatgaa aaccgcaagc caagcgaaaa caacgaaaca gacagccttc tatacaccga 929161 cgcccgaaaa cggaaaagct aagcagctct catctggaac agaggtgaca atacttgggt 929221 ggggattcag tgaaaacggc ggatttgact tcacttgggc gttcgtggat tatggcggag 929281 ttaaaggcta tattcacaca aaggatttac aaatgcgata aaaaggcagg ccgaggcttg 929341 tctttttgcc tatgcatgaa acatttcttc tttctgcacg taacaatgag aaaggagatg 929401 atgatatgac gggtttagtc ggcggagggc ttatgatcat tgcgggcata ctgatcaaac 929461 tgtttcctcc caaatcgatc aacagtgtgt acggatacag aacgagacgc tcaatgtcag 929521 atcaaagatt atggaatgaa gcgaaccgtt acagtgcatc attaatgatc ctgtcaggct 929581 tggtgattgc gggaatgggt ttgctgctgg gatcaaactt gtttattctt cagcttatcc 929641 tgctgattgc cgcctgtgtc ataacattta tgctaacgga gaaaaggctg aaaatcatga 929701 cgcacagtca aggaggagat agaagtggac ggagttaaat gccagtttgt caatacgaac 929761 ggaatcacgc ttcacgttgc agccgcagga cgggaagatg gcccgttaat tgtcctgctc 929821 catggatttc ctgagttttg gtacggctgg aaaaatcaaa tcaaaccgct tgttgatgcg 929881 ggttaccggg tcattgctcc tgatcagcgg ggctacaatc tcagtgacaa accggaagga 929941 attgattcgt atcggattga tacattaaga gatgatatca tcgggcttat tacgcaattc 930001 actgatgaaa aagcaattgt catcggtcat gactggggag gagctgtcgc atggcatttg 930061 gcttccacac gcccggaata tcttgaaaaa ctgatcgcga tcaatatccc gcacccgcac 930121 gtcatgaaaa ccgtaacgcc gctttatccg ccgcaatggc tgaaaagctc gtatatcgca 930181 tacttccagc tgcccgatat accggaggca tcactaaggg aaaatgatta tgatacatta 930241 gacaaagcga ttggattatc cgaccgtccc gcgcttttta catccgagga tgtcagcagg 930301 tacaaagaag cgtggaagca gccgggcgcg ctgacagcta tgctgaactg gtacagagcc 930361 ctcagaaaag gaagcttggc agagaaaccc tcttacgaaa cagtacctta ccgaatgatc 930421 tggggaatgg aagaccgctt tttgagcaga aagcttgcga aagagacgga aaggcattgc 930481 ccgaatggac atctcatctt tgttgatgaa gcttcccatt ggattaacca cgaaaagcca 930541 gccatcgtca atcagctgat tttggaatat cttaagaacc aataagctaa aatttctctc 930601 catccgtctg tcataatggc agactttttc tgtgcgtttt ttttcatagt ctgttttaaa 930661 catgacaaaa taacattaaa aatcatgaat gtcaccataa aattgtaaca aaaaacaggt 930721 ttaaacgact ttaaaaaaag gaatagcctt actgaagatt tgtgtaaaac tcccctaagg 930781 caatacttaa aaagaataat aaaaagaagg tgccttaatg aagcaaggat taatctcgat 930841 tattatcccg tcttacaatg aagggtataa tgttaaactc attcatgaat ctttaaaaaa 930901 ggaatttaaa aacattcatt atgactatga aatattcttc ataaacgacg gaagtgttga 930961 tgacacgctt cagcagatca aagacttggc agcgacgtgc agccgggtaa aatatatatc 931021 tttttctcga aactttggaa aagaagccgc aattttggcg ggctttgagc atgttcaggg 931081 cgaggcggtt attgtcatgg atgccgatct gcagcatccg acatatttgc tgaaggaatt 931141 tatcaaaggc tacgaagaag ggtatgacca agtcattgcc caaaggaaca gaaaagggga 931201 cagctttgtc cgctcactct tatcatctat gtattacaag ttcattaata aagcggtgga 931261 agtcgatttg cgtgacggtg tcggtgactt cagattgtta agccgccaag ctgtgaatgc 931321 acttttgaag ctgagcgaag gaaaccgctt ctcaaaaggc cttttttgct ggattggctt 931381 tgatcagaaa attgtatttt atgaaaatgt cgaacgaaaa aacggcacct ccaaatggtc 931441 gttcagcagt ctgtttaact acggaatgga cggcgtcgtt tcatttaatc ataagccgct 931501 gagattatgt ttttatacag gcattttcat cctgctgctt tccatcattt atatcattgc 931561 cacattcgtt aaaattctga ctaacggtat ttctgtgcct gggtatttca ccattatctc 931621 agcagtgtta tttctcggcg gagtacagct gttaagtctt ggaataatag gtgaatatat 931681 cggccgaatc tattatgaaa caaaaaaacg cccgcattat ttgatcaaag aggcgaatat 931741 cccgaacaaa gacctgcctg aaacgaacga attaaaaagc atgcggcgtc tgacaaaaat 931801 gcactgaaaa taccaagcgc cattggcagt gctttttttg cgtgtctatt atcttaaaag 931861 caagactgga gaattcatat gaaaagaaaa catatcatga tctatgcggc cagtttgctg 931921 gtgtccgttc tggcacacgc tttttttgtg aaagaatggg cggaaggcag gtatatgaca 931981 ggtccgggtg acgggcttgc gcaaatgatc gtatttaaaa aattattatt tgaccaatat 932041 acacacggga attttttcta caattattca ttcggacttg gcggcggcac attcagtcag 932101 ctcggctatt atttttctgc gtcttttctt tttcttgctg tgtctgccgc tgtttggctg 932161 cttcaagccg tccagctgat cggagaaacg gatacgcttt tttgggcaga gtcagctgtt 932221 tttatcagta ttttcaaatt gagcttgatc atctttacgt ccgcttctgt ttttcattat 932281 cttcttaagc acagggcggc atcgttcacg ggagccgtgt tatacggcgt ctcaattatt 932341 tatttccgtc acgaagcgta ttgggaattt ttcaccgata caatggtttg gcttccgctg 932401 cttgtgcttg gcgcagaaaa aattattaga gagcggcgtc cggcgtggtt tatcgttgcg 932461 tgttcgctga cgttaatcaa caatttttac tttgcataca taaaccttat attcatcgga 932521 atctatgtgc tgttcagatg gctgatccgt ttggaaccac atgaagagaa aagatggatt 932581 caaatcagat tatttctcgt ttcaggcttc atttcttttg gcatcagtgc ggcggcgttt 932641 gtgccggtag tatacggttt tttaaacaac ctgcgccctc catacagcca gaaaatagag 932701 tggctcaatt tcgatgataa tatcttattt tcgagccgga tcatcattgt gccggccgct 932761 tttctgctgt ttttgtttat tatttctttt tacaaaaacc gtgtgtttcg tctctttgcc 932821 gggttgagcc tgctgtttat tctgtttcat ttcagtccgt atgcggcaag cgtctttaac 932881 ggtttttccg ccccgcaaaa ccggtttgaa tatgttctgg cctttaccat tgcgggagca 932941 gctgcggctg gtttgtcaca gctgtctgaa ttgaaacgga aagaactgct cccggccgca 933001 gctgtcgtcc tgcttcttta cttgtatcat atccaaaggt ataagctcga tatatggaag 933061 cctgcgaatg aaagtattct attgctctta ctcatgacaa tcgcagcctt gtttgctgca 933121 gcttttgcga aaaaacgggc aaaaatggct gtgtacggta taatcattct ttcttcgctg 933181 tttgtcgcca actcctatca aaaatacgcg ctctcagaag gcggcgattt ggacagtgtg 933241 acaaaagaat atcttacaag tgaggaatac agagggcggg aatcatctga gctcatcaga 933301 cgtttacaga aggaagacga tgacccgctc atgagaatcg actggatgaa cggggtccgc 933361 aataatacgc caatcattta cggatttaat ggcttcagcg cgtattccag cattttaaac 933421 aaagatctgc tggccttcta ttggaatgat ttaagcatcg atatgggcag ggaaagcgtc 933481 agccgttacg cgtcattggg agacagggcg aatttataca gcctgcttta cggcaaatat 933541 tatatgaccg aaaaaacaaa cgaagccagc gtcccgtacg gcttcaaaaa gcatttagaa 933601 acagagcatt atgcagttta tgagaatcag tacatgcttc cattcgttaa aacagcggat 933661 gccatataca gcgaaagtga gctggaccga ttgcccgctc ttgcgaaaga acaggcgatg 933721 ctgaaaggaa ttatattaaa agatccatca ggaaaaacgg agcagacacc aaaaccgtcc 933781 aatttgatca ccaagtcgga catcaccgca aaacaagccc agtatcaaaa cgggctgcta 933841 accgtaactg gagaaaacgg aggagagctg atcatcaccc cgaaacagcc atcatccgct 933901 ccgggagact actatgtcag cttttatttg aaaagcaaag caaaagacaa aggatttaca 933961 ttaaaggtaa atgattatgt cacaacaagg aaatcgaaca aatcgatcta taaaaccgga 934021 gtaaataata taacggtaag agtgcctaaa tcaggccata tctcaatcaa tcttccgaaa 934081 ggaacctatg agctgagaaa catagcgctc tatgaagaaa attaccaaac gctgaaaaac 934141 gctgtaatgc aaaataaaac agagaaagca gacaaactga attggaacaa aaatcgactg 934201 accttttcct atcatctgtc aaaagaccag tacatcatgc ttccgatccc atatgaaaaa 934261 ggctgggagc tgaagatcaa cggaaaaaca cagaagatcg aaaaagcgga ttatgctttt 934321 ataggcttca aggcgcaaaa gggagacaat cacattgagc tgacttacta tccgccatac 934381 ttcaaaatat cggcgatcat atctctcgtc agtctgctgc ttgctgtttt ttatataaga 934441 cgtaaaaagc ccggctctat atagagccga gctttaattt tttctgaagt ttttcttcgc 934501 tgaatatcca tcccgtatag gatgaacgaa tcgtgagatc atggccgata tgaacaattg 934561 cgacaaacgg ataatggcct ttgctccgat aacgcaggtc gataaatctc acctcataat 934621 gatctttaaa cgtatccact tcccaccggt ataccggaga aaaggacaga aacgccgcga 934681 tgttatcatc ctgctttgcc gcatgcatta catcggtttc aggaacaggc acccgattaa 934741 atgtatccag aatcacgaca tgtccttcca tgcttcttcc tacatagaaa gcatgtgctg 934801 tcgtcactgc gattcgccat tgcctgaatt tcatcgttgg agaaataata atgctttcga 934861 tctcatcatg aatcatctca tgaagcttcc gtttaattct cagctgcatg atcaggcgca 934921 ccaagtagta gcctaccaat atgatatata agctgagaaa cgtgatgccg ggactcccgc 934981 ctgcatacca aatcgcgata gctgccagat ggctgataaa aataaacgga tcaaacgtat 935041 taatcagccc gagcgcaacc cattttttcg aaaacggacg aatggcttgt gttccatagg 935101 cgttgaatat atcaacaaag acatgcagaa cgactgccag cagtgtccac agccacaggt 935161 gcagaaaatc ggcctgagga taaaataaat acagaatcgc cgggatgatg acagaccaaa 935221 acaaaacggc gggaattgaa tgggtaaatc ctctgtgatt ccttatataa acagcattgt 935281 ttttaagctt taacacagta tcaatatccg gagcctgaga gcccgcaagc gttgcgatca 935341 taacagcgtg agccattgcc ggatctgatc cgacaacagg atcaagcgtc gcaataccgc 935401 ccagtgcgat gcccataacg acatgtgtgc ccgtatccat aggtgacctc cttgcagggt 935461 gatcctgcac attcactttg taagaaattc cccattttca tatacccaat ttttaaactg 935521 attcaatcgt tctcatatgt ttccgctttt tctttattac tatttaatgt aacatattat 935581 cgtactgtgc ccttagtgta caacaaaaaa cagtctaaag aaaagcgggg cgcgaaagac 935641 tggggagaaa cacatatgaa cgtacttgaa gacaaattaa aacaaaaaga catacagcaa 935701 tttcgcgatg atttaatctc atggtttgaa cgagagcagc gcgttttgcc gtggagagag 935761 gaccaagatc catataaggt gtgggtatct gaagtgatgc tgcagcaaac gagagtagag 935821 acagtgattc cttactttct ccggtttgta gaacaattcc cgacagtgga agcgctcgct 935881 gatgctgatg aagaaaaggt gctgaaagca tgggaagggc tcggctatta ttcgcgagtc 935941 agaaacctgc aaagcgcggt aaaagaagtg aaacaggaat acggcggcat tgttcctcca 936001 gacgagaaag attttggcgg gttaaaaggc gtcggccctt atacaaaggg agcggtgctc 936061 agcattgcct acaataaacc cattcccgcg gttgacggaa atgtgatgcg tgtcatgtcc 936121 aggattctat ctatttggga tgatattgcc aaaccaaaaa caagaacgat ctttgaagac 936181 gccatacgag cttttatttc caaagaaaaa ccatctgaat ttaatcaggg cttgatggag 936241 cttggagcct tgatctgtac gccaaaatca ccctcatgcc tgctttgccc ggttcagcag 936301 cattgctcag catttgaaga aggcactgaa cgggagcttc cggtaaaaag caaaaagaaa 936361 aagcccggga tcaaaaccat ggccgcgatc gtactgactg atgaagacgg acaagtgtat 936421 atccacaaac ggccgtctaa aggtttgctc gccaacctgt gggaattccc gaatcttgaa 936481 acacaaaaag ggatcaaaac tgagcgtgaa cagctcattg ctttcttaga aaacgaatat 936541 ggcatacaag ctgatatcag tgatctgcaa ggtgtagtcg agcatgtttt cacccacctg 936601 gtatggaata tttcagtgtt tttcggtaaa gtaaaacaag tgtcggatac cagcaagctg 936661 aaaaaagtaa cgaaagaaga gctcgaacaa tttgcgttcc cggtgtcaca tcaaaaaatc 936721 tggaagatgg caggagaagc agccgccatc tcggctgctc cgtaaaccat tcttaatcgt 936781 aagagacgcg cgtgccgtgg ctgtagtccg cttcattgcg cttcattccg ccgcgcgctt 936841 caatttcttg cgttaattcc cggtattttg attggccttc ttcgttcaaa taaggcataa 936901 tttgctgaaa ggcatgatga aaataagcga gttcactgtt cttccaatct tttttggaaa 936961 ccatgttcaa ttcgctcata tcacgtccga catacataac agaagacccc ctttaaagtt 937021 cttgccatta ttgtttgtgg aaataaaaga actatacgct acaaggagat gaggaaaaat 937081 ggaacaaaat aaatgtgcac tcgtaacagg aagcagccgc ggtgtcggaa aagcggccgc 937141 gatcagactt gctgagaacg gctataacat cgtcattaac tatgcacgca gcaaaaaagc 937201 agcattagaa acagcggaag aaatcgaaaa gcttggcgtt aaagtgcttg tcgtaaaagc 937261 aaacgtagga cagcctgcaa aaatcaaaga aatgtttcag caaattgatg aaacgttcgg 937321 cagacttgat gtttttgtca ataatgccgc ttcaggagta ctaagacctg tcatggaatt 937381 agaagaaaca cactgggact ggacgatgaa cattaatgcg aaagcattgc ttttctgcgc 937441 tcaggaagct gccaagctaa tggagaagaa cggtggcggg catattgtca gcattagttc 937501 attaggctct atccgctatc ttgaaaacta caccacggtc ggtgtatcaa aagcagcgtt 937561 agaggcttta acccgttatc ttgccgttga gctttcacca aaacaaatta tcgtcaatgc 937621 tgtttcaggc ggagcgatcg acacagatgc gctgaagcac ttcccgaata gagaagatct 937681 gcttgaggat gcgcgccaaa atacgccggc gggacgcatg gtcgaaatta aagacatggt 937741 tgatactgtg gagtttctag tgtcttccaa ggctgacatg atccgcggac agacaattat 937801 cgttgacggc ggacgctcac tgctcgttta aaaattttta aaaaagagga atagctatac 937861 gatcacctgc acattctaat gaccgtggag gtgataacaa tggctaactc aaataacttc 937921 agcaaaacaa acgctcaaca agttagaaaa caaaaccaac aatcagctgc tggtcaaggt 937981 caatttggca ctgaatttgc tagcgaaaca aacgctcagc aagtcagaaa acaaaaccag 938041 caatcagctg gacaacaagg tcaattcggc actgaattcg ctagtgaaac tgacgcacag 938101 caggtaagac agcaaaacca atctgctgaa caaaacaaac aacaaaacag ctaatcactg 938161 aaacagaaaa aagcacttca tcttcgggtg gaagtgcttt tttctgtttg aaaaacgaca 938221 aaacttgtgg aaggtctaca gaatgagtca aagggtttgc tttatggaga tcgaaatgat 938281 taaaggagga aatgtttata ctttcatcag gctgaaggag gaaccgatga ccgaatttga 938341 aaagctggta agtgaacaga tgaaaacgat ggataagctt ctcgatctcc aatcagagct 938401 cgaccgctgc aaacaaattg aggcggaact ccggcatttg gaaagggatg caaggctgcg 938461 tgggattcag gctgaaattg cggtaaaacg gaaacacctt gccgatatac aggatatgtt 938521 tcaaaagcag acagagcagg tcattcgttc atatcgcagc tcagaaaagc cgtcttcctt 938581 tgtgtagtgc aggaatgtgc cattccccgg ccggaatggc tcttttattt tcatttttca 938641 atttgtaacg ttataatagg taaaagacgt tgtcggtaag caaatttgga catactaact 938701 gtagggcttt atagaaagta ggggagaaat atgggctatc ccaaggaagg agaaaccatt 938761 caaattcaca gctataagca caacgggctg attcatagaa tttggaatga gacaacaatc 938821 ttaaaaagta cagaaatgtg tgtcatcgga gccaatgacc ggacgatggt aaccgaatca 938881 gacggccgga catggataac cagagagccc gcaatctgtt attttcacgc aagacaatgg 938941 tttaatgtca tcgggatgct gagggaagac ggggttcatt attattgcaa catcagttct 939001 ccgtttgcct atgatggcga agcaattaaa tatattgatt atgacttaga tgttaaggtt 939061 tttcctgaca tgacctacaa tattctcgat gaagacgaat atgatgatca tcggaaagcc 939121 atgaattatc caaaagaaat cgacagtatt ttaagagact acttaaatac gctgctccat 939181 tggattcacc agcgtcaggg accgtttgcg cccgagtttg tcgatatgtg gtatgaacgg 939241 tatttgcgct atacaaaata atggttacgt aaaaacctgt tgcggggtac aacaggtttt 939301 tcacatgggc tcacacacat catgataaag agagaggggg aatcaaccgt gggggttatg 939361 aaacgctaca tgcaattcgt caaaccttat aagaagcaaa ttttcgttac agtgttaatc 939421 gggatcgtaa aattctccat tccgcttgct ctcccattgc ttctgaagta cgtagttgac 939481 gacattattc aaggaggcgg cacggccagt gacaaaacca cgtcattgtt cacgattatg 939541 gcgatcatgt tcgccttatt tttaattttg cgcccgcctg ttgaatatta ccggcaatat 939601 tttgcccagt ggactgccag caaggtgctt tatgatataa gagctaagct gtttgaccat 939661 atacaaaaac tgagccttcg tttttacgcg aatacaagaa caggggaagt catttcccga 939721 gtgattaatg atgtagaaca aacaaaggat ttcgtcatca cagggctgat gaatatatgg 939781 ctcgatatgc tgacgatttt gattgtaatc tctatcatgc tcacactgga cgttaaatta 939841 acgctgatct ctatcgtttt attcccatta tacggaatat cagtgaagta tttttacggc 939901 cgtttacgaa agctgacaag ggagcgctca caggctcttg ctcaagtgca ggggcatttg 939961 catgaacgca ttcaaggcat gcctgtcatc agaagctttg cgatagaaga tcatgaacag 940021 gctcaattta atgagaaaaa cggtcatttc ttagataaag ccatccgcca cacgaattgg 940081 aacgcgaaaa cctttgcggt cgttaatacc attacagatt tggcgccgct catcgtcata 940141 gcgtgcgccg ggtattttgt cattaatgga ccgctgacag tcggaacaat ggtcgcgttt 940201 gtcggatata ttgacagaat gtacaaccct gttagaaggc tgatcaattc ctctacaact 940261 ttgacacagt caatcgcatc aatggacagg gtgtttgaat ttattgacga gccctatgaa 940321 ctcactgaca aaccaaatgc gataaaggcc gatcagattc gcggaggagt ggagtttcaa 940381 aacgtttcgt ttcaatatga gaaggacaaa gaaaatattc ttcatgatgt atccttaaaa 940441 gtaaatagag gagaaactgt agctctcgtc ggcatgagcg gaggaggaaa atcaacgctc 940501 gtcagcctga tcccaagatt ttatgatgta acaagcggca gactgctgat tgatgggacg 940561 gatattcgcg attatgaagc aagaagcctt cgcaaccagg ttggtatggt gcttcaagat 940621 acctttttat ttagtgaaac gattcgggaa aatatcgcga tcggcaagcc tgatgccaca 940681 cttgaagaga taatcgaagc cgccaaagct gcaaatgccc atgaatttat catgagtttt 940741 ccagaaggat atgagacccg ggtgggggaa cgaggcgtta agctttcagg cggacaaaag 940801 cagcggatct caattgcgcg ggtattcctg aaaaatccgc cgctcctcat tttagatgaa 940861 gctacatcag ctctggattt ggaaagtgag cattacattc aagaagcgat ggacaaactg 940921 gcgaaggata gaacaacttt tgttgtcgcc caccgtttat cgacaatcac ccatgcggat 940981 aagattgttg tcatggaaaa cgggacaatc attgaaatcg gaacccatga tgaactcatg 941041 gactatgaga gccaatacaa gcacttattt accattcaaa atttgaacta aaacatcaat 941101 cttatatcct tttaacgaag gatataagat ttttttgtat ataaaaaaac ccggctgttt 941161 aaccgggtta ctcttctgtt tctatttcgc agtctttcgg atgatacgtt tgaaaacttg 941221 tgataagtgt ttctaaatgt tcaagctgct cgcgatattc cacggcgctt gccataatat 941281 tgagcatgtt gtaatcaata agctcctcat ccgtattctg ctgatttttt aaaaatgact 941341 ttgttaaaag ctgcttatac cggatgcctt cttcaaccgc gtcatcatgc ggcttgattt 941401 ttccgacaaa cctcatcaaa atccgctcgt gccagtaaag caggtaatca agttcttcag 941461 tcaatgtttc ctgaaactct tccggcatat gatagatctc gttttccaga cgatgcagct 941521 tcttcaatgt atcaagcgcc cgatttgcag taataatggc ctgtctgaac aggacaagct 941581 ttcttgattt cacataagtc gttttcttaa agtaacttct ttcttcttta tatagaagat 941641 atgtctgatc aagcttgatc attttttctt tcagtttttc aatatcctct ttcaaaatcg 941701 aatgctctgt cgactgccgc atggacaatc tgatccactt cataatttct tcggtgtttt 941761 cgacggtatt atgaatcagc tttgtttcgt acttaggagg caaaaacaca aggttgacga 941821 taaaggaaga aagcacccct aagatgactg tgcttgttct gatcagcgcg aacattaaaa 941881 agtcgtcacc ggcagattct aatatcgcaa tgactgttac aagagcaatt gaaattgtat 941941 gttcaatttt aagtttcagc atgattgtaa tgacaataac tgctgttaac ccgatcataa 942001 tcgggctggg tccgaaaata aggccgaaca ctgtggcaat cacagctccg atgatatttg 942061 cttgaacctg gtcaataata atgagaaaag agcggtaaat cgacggctgg atcgcaaata 942121 tcgctgcaat tccagcgaaa atcggcgcgg gaagcccgat ccacgaagcc aaataaaggg 942181 caagtgtaat cgcaatcccg gttttgaaaa tgcgggcacc aagtttcatt ggtttgtgcg 942241 tgcattcctt tctatagtaa attgtgtgac atagcaaatg ggctaatcct taaaattccc 942301 ggttagttta tttgctaaac aattaagtaa tatacaggga tcgatacaaa tattcaagct 942361 atttttctag aaaaagacca aaatcttaca cgctgtttga ttccataaaa aaacaggagc 942421 tcaaagctcc tgttcaaggt atttgattct agttttttag atgtttaaat gcatcctcga 942481 ccgctgtaag cgtgtcttta atatcctgct ctgtatgtgc tgtggtaata aaccaagctt 942541 catacttaga aggtgctaaa ttaattccgc gttccagcat cagcttgaaa aacgtagaga 942601 atgtttctcc gtcactccgt tcagcctgct cgtaattttc cactttctca tcagagaagt 942661 ataccgtgag cgcacctttt aaccggttga ccgtaatggt gatgccgtgt gtttctgcgt 942721 gcttcaaaat gccttcctca agcatagcgc caaggtgatc aagcttttca tacacgcctt 942781 tttctttgag cacttccaga caagcgatgc ctgataggat ggaagcgggg ttccctgcca 942841 ttgttcctgc ctgataagca ggccctagcg gagctacctg ctccatgatt tcttgtttgc 942901 cgccataggc cccaatcgga agtccgccgc cgataatttt cccgagtgct gttaaatctg 942961 gtttcacctg taagagatcc tgcgcgccgc catacataaa gcggaaagcc gtaatgactt 943021 catcgtaaat aacgagagcc cctgcattat gtgttaattc atttacttgt tctaagaagc 943081 cctctttcgg ctccacgata ccgaagttgc cgacaatcgg ttcaacgaga accgccgcga 943141 tttcactgcc ccatttttca agagctgctt tatagctatc gatatcatta aatggtactg 943201 tgatcacttc gtttgcaatg cttttcggta caccggctga gtctggtgtg ccgagagtag 943261 acgggccgga gcctgcggcg acaagcacaa ggtccgaatg cccgtgatag cagcccgcaa 943321 atttaatgat ttttgtccgg cctgtatatg cgcgagccac gcggatggtc gtcataacgg 943381 cttctgtacc cgaattgacg aatcttactt tgtccatagc gggaatggct tctttgagca 943441 tttttgcaaa tgtaacctcg tgtttcgttg gtgttccata caatacaccg ttctctgctg 943501 cttttttaat cgcttctgta atatgcggat gggcatgtcc tgtaataatc ggaccgtacg 943561 ccgctaaata atcgatgtat ttgttgccgt ccacatccca aaaataagcg ccgcttgctt 943621 tctccattgc aacaggagaa ccgccgccga ctgctttata tgatctagac gggctgttta 943681 caccgccgac aatgtgctgt aatgcctcat tgtgaagttc aattgatttt gtatgcaaga 943741 ataaaaacct cctatatctc catgcgtcct ttctattgta gcatgcttcc gaacaagaac 943801 aatggcttcg ggcttcagat tcagctgaga tggttgtaat ctggacaaga attggatacg 943861 cttaataaaa aaacatccgg aggtaacgta atgactatag aaatcggaca aaaagcgcct 943921 gatcttgagt taaaaggtga tcatggggaa acagtaaaat tatcggatta taaaggaaag 943981 tacatcgtgc tttattttta tccaaaggac atgacaccgg gatgtacaac tgaagcatgc 944041 gattttcggg acagtcacga aagcttcgcc gaactggatg ccgtcattat cggcgtcagc 944101 ccggacagcc aggaaaaaca cggaaaattt aaagagaagc ataaccttcc atttctgctt 944161 cttgttgatg acgagcataa gctggcggaa gcatttgatg tgtggaagct gaagaaaaac 944221 ttcggaaaag agtatatggg aatcgagcgt tccacttttt taattgataa agaaggccgg 944281 ctcattaaag aatggagaaa agtaaaagta aaggaccatg tagccgaagc gcttcaaacc 944341 ctcaaagata tgtctgaaaa gtaaatctct atgagcctat gcttactttt accctgatat 944401 caattgacaa attatcgtag aaagagttac actaattata aacattacaa tgtaagaatt 944461 ttttttagaa gagaggtgca tgacggatgg ctgcacatga actaaaagaa gccttagaaa 944521 cgttgaagga aaccggagtt cgcattactc ctcaacgtca tgcgattctg gaatatctcg 944581 ttaactctat ggctcatcca acagcggacg atatatataa agctctggaa gggaaatttc 944641 ctaacatgag cgtagcgacg gtatataaca atttgcgtgt gttccgggaa tcaggtttgg 944701 taaaagagct cacatacggt gatgcttcca gcagattcga ttttgtcaca tccgatcact 944761 atcacgcgat ttgcgaaaac tgcggtaaaa ttgtggactt ccactacccg ggccttgatg 944821 aagtggagca gctcgctgcc cacgtcacgg gcttcaaggt aagccaccac cgtttagaaa 944881 tttacggcgt ctgccaagag tgttcgaaaa aagaaaatca ttaaaaataa gctgaccgca 944941 cgaaacggtc agcttatttt atttcgacat tttcttttta ttataagact catcaaattc 945001 ttttccttct aatcccttat ctaaagtcag cggctctcgg caatgcatgc acatatcgac 945061 tactcctaaa acctttgtct ctttatcaca gcctggacaa atgacgcgaa ccgctttagt 945121 cgaaagcatt ccgatccaaa agtaaactac cgtgctgaga ccgatggata aaagcccaag 945181 tatcataaac aaactagaaa gcaaaactga ctctttgaaa aagatcccga tgtacataat 945241 gataaaccca acgaaaacca aacttaacgc aaatgttctg attttattaa ttttgctgga 945301 gtatttcgcc atgtccatcc ccctctgttt taactatagc acaaacccga tgggattttc 945361 ttcatgtttt cggttgaact ggaatttaca tatggagagt tactgtgaaa ttgtttataa 945421 tagttcaatg tgtttagaaa aaaggaattt cgttttaacc atagaattga atcaaataga 945481 gaataaaaaa atttgaacaa ttgcattgga ggaatagtga tggaaaatct tctccgtcca 945541 atttaccaag aaagagcaag tcaccccaat acattggctg tcattatgat tgagagaaga 945601 aacaaaacat cttccttaac agataacttt gatgcagctt tgctggtgat tgtaaaggat 945661 gctgatgagc cagtttttat aaagcattat gaatttgatc atcaaacagc ttctttgcat 945721 gtggtaacag attctcagat tcaagaatgg attttgcttg gaacaaatag aagaatcata 945781 gattggattg taaatggcag agtcttgttt gaccgtaatg aatacgtagt tgaactgatt 945841 gacaggctga atacatttcc gtttgccgaa cgtaaactga agatcggact cgaatacggc 945901 aaattaatca gaaggtatgt tgaagggaaa gctttttttg aagccaatca atttttagat 945961 gcctacaatg ccgttgttca tgcgctgcat catttagcac gtattgaagt aatcgacaga 946021 ggattccatc ccgaaaccac ggtgtggagc caagtgcgcc agatggagcc ccaagtgtac 946081 aaattatatt ccgagctgat tgaaagtcat gagagcctgg aaaaaagact tgaattatta 946141 ttcttagcaa atgattttct catccattcc aaagccgaga tcggttcggc gcatcttttc 946201 gaagtaatga aagaaaaaga catttggcaa ttcggtgagc ttcttcaaca tcatgaccta 946261 aagcacttta cccaagatct tggcgttatg cttgattact tgacggaaaa gggacttatc 946321 aacgtctgcc agatagaaac gaaaggacag gctgtctatc accgaggata ttcttttaaa 946381 aaaggtgttg actctgattc ttgaccgtgt tatattatta aacgtcgctg atgcgcttct 946441 gagaaaacaa gctcacagcg gcgggaaaat aaatcaaaaa aacatttgac aaaagaaagt 946501 caaaatgtta tattaataaa gtcgcttcaa caagaagtga aaatgatctt tgaaaactaa 946561 acaagacaaa acgtacctgt taattcagtt tttaaaaaat cgcacagcga tgtgcgtagt 946621 cagtcaaact agggcctgca cgacgcaggt cacacaggtg tcgccgcagg atgcggtgaa 946681 cttaacctgt gatccattta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc 946741 gtgcctaata catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg 946801 gacgggtgag taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg 946861 ggctaatacc ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta 946921 ccacttacag atggacccgc ggcgcattag ctagttggtg aggtaacggc tcaccaaggc 946981 aacgatgcgt agccgacctg agagggtgat cggccacact gggactgaga cacggcccag 947041 actcctacgg gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa 947101 cgccgcgtga gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt 947161 accgttcgaa tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt 947221 gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg 947281 gctcgcaggc ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat 947341 tggaaactgg ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa 947401 tgcgtagaga tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc 947461 tgaggagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 947521 cgatgagtgc taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc 947581 actccgcctg gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca 947641 caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 947701 atcctctgac aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca 947761 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 947821 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 947881 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 947941 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 948001 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 948061 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 948121 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg 948181 acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 948241 ctcctttcta aggatattat acggaatata agaccttggg tcttataaac agaacgttcc 948301 ctgtcttgtt tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa 948361 cagtagacat cacattcaat tagtaataca agatatcaca tagtgattct ttttaacggt 948421 taagttagaa agggcgcacg gtggatgcct tggcactagg agccgatgaa ggacgggacg 948481 aacaccgata tgcttcgggg agctgtaagc aagctttgat ccggagattt ccgaatgggg 948541 aaacccacca ctcgtaatgg agtggtatcc atatctgaat tcataggata tgagaaggca 948601 gacccgggga actgaaacat ctaagtaccc ggaggaagag aaagcaaatg cgattccctg 948661 agtagcggcg agcgaaacgg gattagccca aaccaagagg cttgcctctt ggggttgtag 948721 gacactctgt acggagttac aaaagaacga ggtagatgaa gaggtctgga aaggcccgcc 948781 ataggaggta acagccctgt agtcaaaact tcgttctctc ctgagtggat cctgagtacg 948841 gcggaacacg tgaaattccg tcggaatccg ggaggaccat ctcccaaggc taaatactcc 948901 ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg aaaagcaccc cggaagggga 948961 gtgaaagaga tcctgaaacc gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg 949021 cgtgcctttt gtagaatgaa ccggcgagtt acgatcccgt gcaaggttaa gcagaagatg 949081 cggagccgca gcgaaagcga gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa 949141 accaggtgat ctacccatgt ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac 949201 ccacgcacgt tgaaaagtgc ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc 949261 tggagatagc tggttctctc cgaaatagct ttagggctag cctcaaggta agagtcttgg 949321 aggtagagca ctgattggac taggggcccc taccgggtta ccgaattcag tcaaactccg 949381 aatgccaatg acttatcctt gggagtcaga ctgcgagtga taagatccgt agtcgaaagg 949441 gaaacagccc agaccgccag ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg 949501 agttgcttag acaaccagga tgttggctta gaagcagcca ccatttaaag agtgcgtaat 949561 agctcactgg tcgagtgact ctgcgccgaa aatgtaccgg ggctaaacgt atcaccgaag 949621 ctgcggactg ttcttcgaac agtggtagga gagcgttcta agggctgtga agccagaccg 949681 gaaggactgg tggagcgctt agaagtgaga atgccggtat gagtagcgaa agaggggtga 949741 gaatcccctc caccgaatgc ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt 949801 cgggacctaa gccgaggccg aaaggcgtag gcgatggaca acaggttgat attcctgtac 949861 cacctcctca ccatttgagc aatgggggga cgcaggagga tagggtaagc gcggtattgg 949921 atatccgcgt ccaagcagtt aggctgggaa ataggcaaat ccgtttccca taaggctgag 949981 ctgtgatggc gagcgaaata tagtagcgaa gttcctgatt ccacactgcc aagaaaagcc 950041 tctagcgagg tgagaggtgc ccgtaccgca aaccgacaca ggtaggcgag gagagaatcc 950101 taaggtgatc gagagaactc tcgttaagga actcggcaaa atgaccccgt aacttcggga 950161 gaaggggtgc tctgttaggg tgcaagcccg agagagccgc agtgaatagg cccaggcgac 950221 tgtttagcaa aaacacaggt ctctgcgaag ccgtaaggcg aagtataggg gctgacgcct 950281 gcccggtgct ggaaggttaa gaggagcgct tagcgtaagc gaaggtgcga attgaagccc 950341 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 950401 ttccgacccg cacgaaaggc gcaacgatct gggcactgtc tcaacgagag actcggtgaa 950461 attatagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc ccgtggagct 950521 ttactgcagc ctgatattga atgttggtac agcttgtaca ggataggtag gagccttgga 950581 aaccggagcg ccagcttcgg tggaggcatc ggtgggatac taccctggct gtattgacct 950641 tctaacccgc cgcccttatc gggcggggag acagtgtcag gtgggcagtt tgactggggc 950701 ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg ttggaaatca 950761 ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc gagcagggac 950821 gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc aacggataaa 950881 agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg gggaggtttg 950941 gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg gttgggctgt 951001 tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt tcggtcccta 951061 tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg accgggatgg 951121 acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct atgtgcggac 951181 gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat ttcccattcc 951241 gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg gaagtgtggc 951301 gacacatgga gctgacagat actaatcgat cgagggctta accatatttt tgaatgatgt 951361 cacacctgtt atctagtttt gagagaataa gtttttcaaa aaaacacttg attttctcaa 951421 gaatacatag tataatgtta aatgtcactg aaattgtctg gtgatgatgg cgaagaggtc 951481 acacccgttc ccatgccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 951541 tttccccctg tgagagtagg acatcgccag gcagacttca ttccgcagta gctcagtggt 951601 agagctatcg gctgttaacc gatcggtcgt aggttcgaat cctacctgcg gagccattat 951661 tggagagctg tccgagtggt cgaaggagca cgattggaaa tcgtgtaggc ggtcaactcc 951721 gtctcaaggg ttcgaatccc ttgctctccg ccactgatac ttatacataa ttacaattga 951781 aagtctgggc ccgttggtca agcggttaag acaccgccct ttcacggcgg taacacgggt 951841 tcgaatcccg tacgggtcat tatatgatgg aggattagct cagctgggag agcatctgcc 951901 ttacaagcag agggtcggcg gttcgagccc gtcatcctcc accattatat catcgcgggg 951961 tggagcagtt cggtagctcg tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc 952021 cccgcaacca aattttaaaa tggtccggta gttcagttgg ttagaatgcc tgcctgtcac 952081 gcaggaggtc gcgggttcga gtcccgtccg gaccgccatt tgaatactta ggctcggtag 952141 ctcagttggt agagcaacgg actgaaaatc cgtgtgtcgg cggttcgatt ccgtcccgag 952201 ccaccaccta tgccggtgta gctcaattgg tagagcaact gacttgtaat cagtaggttg 952261 ggggttcaag tcctcttgcc ggcactgttt tttcaaaatt taatgtggag gggtagcgaa 952321 gtggctaaac gcggcggact gtaaatccgc tccctcaggg ttcggcagtt cgaatctgcc 952381 cccctccacc atttataggg gcatagttta acggtagaac agaggtctcc aaaacctccg 952441 gtgtgggttc gattcctact gcccctgcca aatttatgac atcttgagat tatggcggtt 952501 gtggcgaagt ggttaacgca ccagattgtg gctctggcac tcgtgggttc gattcccatc 952561 aatcgcccca tattatcatt gggctatagc caagcggtaa ggcaacggac tttgactccg 952621 tcatgcgttg gttcgaatcc agctagccca gtctcacttt ttatatcaac tgcatataat 952681 gtattaagtc cattaaaaat gcggaagtag ttcagtggta gaacaccacc ttgccaaggt 952741 gggggtcgcg ggttcgaatc ccgtcttccg ctccaattac ggcggcatag ccaagtggta 952801 aggcagaggt ctgcaaaacc tttatccccg gttcgaatcc gggtgtcgcc ttcttattgc 952861 cggggtggtg gaattggcag acacacagga cttaaaatcc tgcggtaggt gactaccgtg 952921 ccggttcaag tccggccctc ggcaccaatt ttacttacat ggtaagttga attggtgttt 952981 gtgttttatc attataacta atcatattaa tgatctacat aagtagatca tttttttaat 953041 gctttgattt atcataacaa gttaagttcc gaggcctatt ataaagcggc tgtatagcta 953101 gtctttcaac acttttattt tatatttcca taaaaacttt tttgaaatac gttgacactt 953161 tatgagatcc atgatatatt tatattcgtc ggttagatac gacgtaaaac ttgccggtgt 953221 ggcggaattg gcagacgcgc acgactcaaa atcgtgttcc ttctggagtg tcggttcgac 953281 cccgaccacc ggtatactga aaaacccgtt tcttaacaga aacgggtttt tattttttat 953341 taaagaaaag gagcctcggc tcctttttat acttactcag cgtattggtc taggatctct 953401 tctagcacct cttctagctc ttctgtatct tcaagctctg attggctgaa acggacgcgt 953461 acaagctgtt ctccgtcatt atacatctct tccaaccacc ctcggagtcc tcttgctctg 953521 cggtcgactt cgaaaatgat ttccaaaccg tcttcgtcta aaaggaaaat gagctctaat 953581 tcatcaagca tctgacgata atatccggaa gtcggaacga attcgaattc ttgaacgaac 953641 ggaagacgac gctggaagta gggcgcttgt tcgcagtctg cttcgttaag acggaagccc 953701 aggttttcga ttgcttcaag cacattttca atccaagggt gcgcttcaac gaaaatgcgg 953761 tcatgatcgg atttatcgat accgccttga atgtcaaggt ctgtcaccac ggcaacctct 953821 actttcccta cagtgatcgg cgtatctaga ggcagagtga atgtgaacgg aaattgatgc 953881 tcttcaccag gctgtatggt aaatgaacca gtgacccgga aagaatgaat tgtagcgtat 953941 ttccggtgct cttcatcgtc ttttacaatg acataccgtg tgctaagctg taaatcgata 954001 taacggatgt cctgagcgat ttttccgcct ttgacatgta ccgttccctg tacttcttct 954061 cctggaaaat atgcgtcttt ttctaaaatt gtatctactt ttgcagctcc aattccggca 954121 cttgccgcaa gcttcttaaa aaatgacatg ttagatcttc ccctttttct tttttctcaa 954181 cagatatacg taagaaggag gaaaaaagat tcgtttgatt catacttttt tcctattatt 954241 cgtctcggcc tagggacaga ctaagaataa tattgaaaat aaaggagtcg atggaagtga 954301 ataaagaaag tttggttgca gatgaattac acagaatgtt tttggctggt gagctgcaaa 954361 tcacagtaga ggaggatata aacaatattt ccgaaaggct gagaaacggc gatctcagtt 954421 tagaccgatt aagcggtgaa gacgtgttta taaaagaaac ggtaaatgag gctttaagaa 954481 gagtggagca ataaaaaaga gacggcatct catctttgag atcccgtctc tttttgtggt 954541 ctttgctgta agataaaagc gaatcgattt ggaattgctc acccgagcca ccccttttct 954601 aacagaagat ctgacagttc atcatggaga taaacagctg tatctaattg atcatgcaat 954661 gctcttctga tgtggggatt ttcggttgct gttgttgcga cagtgtattt gttaatgctg 954721 gtttttattg ttgttaacaa atcaagaata tctttgggac aaagactttg ttcaatggga 954781 aaccacctcc tttgtttttt tagcagctcc tgataagaaa gtatttgact ttgtttcttg 954841 cttctataca aaatgctata ataagcaaca aattttgttg gggggtgtga tgatgaagca 954901 gattattgcg atggggggcg ggggtttttc gatggagccg gataatttgt ccctcgatca 954961 atatatcctc aatcaatcaa aacgagagca gcctcgtatt tgttttttgc cgacggcgag 955021 cggagattcc caaaactata ttcagcggtt ttatcatgca tttcaaacat tggattgcgt 955081 gccgtctcat ttatctttgt ttaagccacc atcatcagat ttagtttctt ttgttatgga 955141 aatggacgtg atttatgttg gcgggggaaa tacgcggaat ttacttgtgt tatggaaaga 955201 gtgggggctg gaccatattc tcagggaagc atggaagaac ggtgtggttg tagctggaat 955261 aagtgccggt gcgatctgct ggtttgaaga aggggtgaca gattcagccg gaccgctgac 955321 aagtttgaaa agtttaggtt ttttgcaagg gagcttttgt ccccattatg acggggaaaa 955381 ggatcggaga ccggcatacc accagctgat atctaacaag ttcttatgca gtggctatgc 955441 agcggatgat ggggctgctc tccatttcat aaatgatcag ctgtttcaga ctgtgagttc 955501 aaggtcgggt gcaaaggcat atcgggtgat gatggctgaa catgaaatag ctgaaatccc 955561 gttgccggtc aaatatttag ggtgaaattg gctgaatatt atctatattc ctcttttttt 955621 cagattgatt ttatgataag atgagtgcga aatcaatagt tactgggggt gcccgctttc 955681 gggctgagag agaaggcaag cttcttaacc ctttggacct gatctggttc gtaccagcgt 955741 ggggaagtag aggaattgtt tttgttattg tcttgctggg caataatatg tttctttctg 955801 actgtaaccg ggttcattta tatgaatccg gttttttgtg ctggttatgg gcttgatttt 955861 gtcctttcaa acgtagaaag gggaaggaaa agtaatgcaa aacaattcag tgcagcaagc 955921 caacatttcc attatgtcaa gtttttcagg cagcaagaag gtatacgtgg agggttcttc 955981 ttcggacatc caagtgccga tgagggagat tgcattgagt ccgacgacgg gatcgttcgg 956041 cgaagaggaa aacgcgcctg tgcgtgtcta tgatacaagc ggaccgtata cggaccctga 956101 agtaaccatt aatattcaag aaggattaaa gccgctccgc caaaaatgga tcacagagcg 956161 cggtgacgtg gaagagtatg aaggtcgggc tataaaacca gaagataacg gttataaaaa 956221 agcaaaacca aacgtaagct atccaggatt aaagcggaaa ccgctgaggg cgaaggcagg 956281 tcaaaatgtc acacaaatgc actatgcaaa aaaggggatc attacacctg agatggaatt 956341 tatcgccatt cgtgagcatg tgtctcctga attcgtcaga gacgaggtag ccagcggccg 956401 ggcgattatt ccttcaaaca ttaatcaccc tgaaagtgag ccaatgatta tcggccggaa 956461 ttttcatgtg aagattaatg caaatatcgg gaattcagcg gttacgtcat ccattgaaga 956521 agaagtggaa aaaatgacgt gggccatccg ctggggagcg gatacgatga tggatctctc 956581 taccggaaaa gatattcata cgacgcgtga atggattatc cgcaattgcc ccgtgcctgt 956641 gggaactgtt ccgatttatc aggcgcttga aaaagtaaac ggcgtagctg aggatttaac 956701 gtgggagatt tatcgtgata cgctaatcga gcaggcagag cagggagtgg attattttac 956761 gattcacgcg ggtgttttgc ttaggtatgt accgctgact gccaaacgga caactggtat 956821 cgtgtcacgc gggggagcga ttatggcgca gtggtgtctg gctcatcatc aagaaagctt 956881 tttatacaca cattttgaag aaatatgtga gattatgaaa atgtatgata ttgctttctc 956941 tcttggggat ggtttgcgtc ccggatcaat tgctgatgcc aatgacgaag cgcagtttgc 957001 tgaattagag acgcttggag agctgacgca aattgcctgg aagcatgatg ttcaggtgat 957061 gattgagggt cctggacatg ttccgatgca taaaatcaaa gagaacgtcg ataaacaaat 957121 ggacatttgt aaagaagcgc ctttttacac attggggccg ttgacaacgg atattgctcc 957181 gggatatgac catattactt cagcgatcgg agcggcgatg atcggttggt acgggacagc 957241 aatgctttgt tatgtaacgc cgaaggagca tttggggctg ccaaaccgtg atgatgttcg 957301 tgaaggagtc attacatata agatcgctgc gcacgctgcg gaccttgcaa aagggcatcc 957361 cggagcgcaa atccgggatg atgcgttatc gaaagcccgt tttgaattcc gctggcggga 957421 tcagtttaat ttatctcttg atccggagag agcccttgaa taccatgatg aaaccctgcc 957481 tgctgaagga gcaaaaaccg ctcacttttg ttccatgtgc ggtccgaaat tttgcagcat 957541 gagaatttca caggatattc gggattatgc gaagaaaaac gatctcagtg aagcagaagc 957601 cataaataaa ggattaaaag aaaaagcaaa agagtttgtc gatacgggaa gcaatttata 957661 tcaataaaaa aaatgaagat ggagaatgct ccatcttcat ttttttagaa aaacagagag 957721 cgtcgaagcg gaggaatact ctgttcaaag cggaaaacat tttctggatc atatgtcgtt 957781 ttgacacggc ggagtcgttc aacgttttcg ccgtaatatg ttcttggcca gtttctgatt 957841 tcgatatctg gccaatttac gtagtctccc atcgtttctt tcgaaaggga cgttctcagc 957901 ccctcaatcc agcggacatt ttgtcttttt tctccagggg atgtccagtt tgttaagtat 957961 tcctgggcga tgattgcgtc acgataataa aatgccgttt ggtcgggagc gacccgtccg 958021 gctgccccgc cgagtgcttg ctgccagaca ctggcgtttt gattcggagc gtgctctaaa 958081 aagtgtttta ttgttgagat cgcacgttct gataatggct tttcaatgaa agagccggag 958141 cgtttcattt tttgaggctg attgcctccc gggctgttaa aaaaggttac cgcttcaatg 958201 aatggcgttg tttttaccat tccgcttgtc ggacttcctg ctttcaataa aggctttaac 958261 agttttttta actctgtttt tggcccgaca aattggccga gggcttctat gcggtttact 958321 tctttaggcc aaaactctat tgatgatgta agccggtcat ctgtatacgg ggcccagttc 958381 tgccacgtgt tatatacttc ctcaaaatca tcccatcccc atgtaataga aaaaatcgac 958441 acttgagaga tgggcactgc tttaaatgtc atggaggtga ctatgccgaa attgcctcct 958501 ccgcctccct gagacgccca aaataagtct ggatgatttg aacagctgac tgtaatcaga 958561 tcagcgccct ctttttcgtc tgctacgatc atctcaagct gcacgaggct gtcgcaagta 958621 agaccggcag cccttgttaa aagtccaatt ccccctccga gagttaaacc tgtgagccct 958681 acattagcaa tggtgcctgc gggaagcgtc aggccgtatt gccagagtgt ccgatagact 958741 tctcccaatt cagcccccgc ttcaatatag gccagctttt tatcctgatt cacagttatt 958801 tttttcatct cgcttaaatc aataacaaga ccgttattta aaagggaaaa gttctcatag 958861 ctgtgtctgc cgcctctaat acggaaaggc acacggtttt cacgcgccca tttcagcgca 958921 ttgagtgcat cctgtttgtt ttggcaaaac acaatgatgt caggatacct ttctaagctt 958981 aggttaatat tggttcttgc ttcgttatag tccggatcat cccgtgtcac gatacgtccg 959041 gtcaattttg tcttttccac actcccacat ctctttctct cgtattctag tttctctagc 959101 ttatgcgtca ggggaaaaga gtgtataagg aaaaagcggg gatgcaatct gatacagtgt 959161 caacaccctc aaaaaatagt tgacaggtcg gtattgtatg aattaacatg gtcagtacaa 959221 atttttcaaa tttatcgcgc tgatcggaac accgaaggct cttatcgttt agataagggc 959281 cttttttgta tgaaaaaggg gggattattg atgggagtca aaaaagaaaa ggggagaaaa 959341 cgattcagga agcgaaaaac ctacgggaat cagattttgc cgcttgagct gctgattgaa 959401 aaaaacaaac gagagattat aaacagcgcg gaactcatgg aagaaattta tatgaagatt 959461 gatgagaagc atacgcaatg tgtaactaaa tataaaaaaa cccgctgact acaacgggtt 959521 tttgcatttc tccattaaga atctttttta atcggcaatc caaggccttc tgccacgcgt 959581 tttccgtatt caggatccgc tttgtagaag tgctcgattt ggcgcagctt gatttcttct 959641 ttttctaccg gcttcatggc attaacgata ttttcaacaa ggcgggtacg ttcatcttca 959701 ctcattaaac gatacagatc gccggcttga gtgtagtgat cgtagtgatc gtagcttacg 959761 ctgtcagcga taccttgtac cggatatgct gcttgcttat cctcaggtga ctcttttgga 959821 ccgccgaagc tgttaggctc gtaatacaca gatccgccgc cgttatcatc aaaacgcatt 959881 tgcccatcac gctgataatt gtttactttg ttgcgtgcgc ggttgattgg cagcgcttga 959941 tggtttgcac cgacacggta gcggtgtgca tcatgataag caaaaagtcg accttgaagc 960001 attttatccg gtgaaacatc aataccaggc acgagggttc caggtgaaaa tgtcgcttgt 960061 tctacctctg caaagtagtt ttccggattt ctgtctagaa ccatgcgtcc gacctcgatt 960121 aacgggtagt ctttttgaga ccaaactttt gtgacatcaa acggatcgaa acggtacgta 960181 tttgcatctt ctaaaggcat gatttgcaca tatagtttcc atgcaggata atcaccgttt 960241 tcgattgcgt tgaaaaggtc ttctgtatgg taatcagggt tttcaccggc aatttttgct 960301 gccgtattga catcaaggtt tttcacgcct tgttctgttt taaagtgata tttaatccat 960361 acgccttcgc cttcggcatt tgtccatttg aatgtatggc ttccgaagcc gtgcatgtgg 960421 cgaagtgtcg caggaattcc gcggtcagac atcaggattg tcacttggtg cagtgactct 960481 ggtgaaagtg accagaaatc ccatacagcc gtagggtttt tcaggtgtgt ttttggatct 960541 cttttttgtg tatggatgaa atcagggaac ttaatcgcat cgcggataaa gaatacaggc 960601 gtattgttgc cgacgatgtc gtagtttcct tcttcagtat aaaatttaac agcaaatccg 960661 cgcgggtcgc gaactgtgtc agcagagcca agttcaccgg caactgttga gaaacggatg 960721 aacaacggtg tgcgtttgcc gacttcagaa aggaaagcgg ctttcgtgta ttttgttacg 960781 tcgtttgtca cttcaaaata tccgtgtgcg cctgctcctt tggcgtgaac aacacgttca 960841 ggaacacgtt ctcggttgaa atgggccaat ttttcgagta aatgtacatc ttgaattaaa 960901 gttggtccgc gagaaccggc agtcattgag ttttgattat ctccaaccgg agcgccccag 960961 ctagttgtca gtttatttga actcatgtta tcacctcttg gaatttataa gaacataata 961021 tcatctctaa gtaaaaagtc aatattattt tataattatt ataaaatagt tatctctatt 961081 aatcgatata tagtatcgaa attgttgaaa aaccttgttg taacagcttt ttatgacact 961141 taataatttt tggagaaata atttttcctt ctctatttgc gaaacaagca gagtaagtga 961201 taaacaagga tatcaaaaat cgtatttaaa aaagagttga catatcggaa taatttgaat 961261 taacatgtta ttcaaacaaa aaaacaattg ggcagctgat cggaccgccg aaggctctca 961321 tctctacaag aacagagatg ggggcctttt tgtttttttt gaaggcgggg ttggcagaaa 961381 gagagggata aaagtggctg tgaccatcag catcaaagaa aaggcatttg ttcaagaagg 961441 ccgcaaaaac acggtcttag aaaacataga attatcaatc gcaccaggcg aatttctaac 961501 gcttatcgga ccgagcgggt gcggaaaaag caccctgtta aagattattg cagggcttga 961561 ttctgaatat gacgggagtg tggaaattaa cggccgcagc gtaacagctc cgggtattca 961621 gcaaggattt atttttcagg aacaccgcct ctttccttgg ctgactgttg agcagaatat 961681 tgcagccgac ttgaatttga aggacccaaa agtcaaacaa aaggtggatg aactgatcga 961741 gattgtcaga ttgaaaggat cggaaaaagc atatccgcgc gagctgtcag gcggcatgtc 961801 acaaagagta gccatcgccc gggccctgct gcgggagcct gaggtgctgc ttttagatga 961861 accgtttggt gcactcgacg cttttacaag aaaacacctg caggacgtgc tgctggatat 961921 atggaggaag aaaaaaacaa cgatgattct cgtgactcat gatatagatg aatctgttta 961981 tttaggaaat gagcttgcga tccttaaggc caaaccgggg aaaatccata agctgatgcc 962041 cattcacctg gcgtatccgc gaaaccggac gactccggat ttccaagcga tcagacagag 962101 agtgctgtcg gaattcgaga aaacagaaga tttggagtac gcagaaggat cagggatata 962161 gaaagggcgg aagcggaaat gaaaaaagga ctcattgtat tggttgccgt tatttttctg 962221 ctcgcaggct gtggagcaaa tggagccagc ggtgaccaca aacaattgaa ggaaattcgt 962281 attggtattc agcaaagctt aagccccctt ttgattgcaa aagaaaaagg ctggttcgaa 962341 gatgcatttg aaaaagaagg catcaaagtg aaatgggtgg agtttcaaag cggtccgccc 962401 caatttgaag gccttgcggc agacaaactt gatttttctc aagtcggtaa ttcgcctgtg 962461 atcgctggac aggcggcagg cattgacttt aaagaaatcg gtttgtctca ggacggcttg 962521 aaagcaaacg gcatccttgt caatcaaaac agcggcattc aagacgttaa gggcttaaag 962581 gggaagaaaa ttgcagtcgc caaaggcagc agcgggtttg attttttgta taaagcgctt 962641 gatcaagtgg ggttgtcagc taacgatgtg acaattattc agcttcagcc tgatgaagca 962701 gcttccgcat ttgaaaacgg atctgttgat gcctggtcca tttgggagcc gtacttgtcc 962761 ttagaaacaa tgaaacacgg agcaaaaatc cttgtgaacg gagaaagcac agatttatat 962821 tcaccgggtt ttactttagt aagaacaaag ttttcagaag agcatccaga cgaagtggtc 962881 cgttttctga aggtgtttaa taaagccgtt gtatggcaaa aggaacatct ggatgaagca 962941 gcggacttat attctgacat taaagatctc gataaaaagg tcgtcgaaaa tgtgctgaaa 963001 aatactgagc cacttaatga gatcatcagt gacgacattg tgaaagcaca gcaggaaaca 963061 gcagattttc aatttcgaac aaaggcgata gataagaaga ttgatgtgaa ggatgttgtc 963121 gataacactt ttatcaaaaa agcattagag gagcattcct caggaggtga tcaatgatga 963181 aagcagaggc tgcgggctcg ctgcccaaaa cgaatgcgga agcggtgcga aaaaagcccg 963241 gaaggaagag atacggctgg atgaaggggc ttttactgcc cgctgtcatc attgccatct 963301 ggcaggtcat cggcgggctg ggggttgtgt ccgctacagt gctgcctaca cctgttacga 963361 ttgttctgac ctttaaggag cttattttgt ccggcgaact gttcggccat ctgcaaatca 963421 gcatttatcg ggcggcactt ggttttttgc ttggcgcggg gcttggattg atgatcggga 963481 ttttggccgg attttccaaa cggacggagc tgtatcttga tccgtcgttg caaatgctta 963541 gaaccgtacc tcatctggcc gtcacgccgc tgtttatttt atggttcgga tttgacgaag 963601 tatctaaaat tttgctgatt gcgctcggtg ccttctttcc tgtctatatc aatacgttta 963661 acggcatccg cggggttgac gcgaagctgt ttgaagtcgc ccgggtgctt gaatttaaat 963721 ggcatcagca gatatccaaa gtgatattgc cggcagccct gcccaatata ttgctaggca 963781 ttcgcttatc gctcggcatt gcatggctcg ggctcgttgt ggcagagctg atgggctcaa 963841 gctcgggagt cggctatatg atcatggatg cgagacagtt ttcacaaacg aataaagtct 963901 ttgcagggat tatcattttt gcagtggttg gaaagctgac ggattccttc gtcaggctgc 963961 ttgaacgaaa gctgttaaag tggagaaaca gctacgaagg ataaaagata taaaggggag 964021 atgaatatgg aaattctttg gtttataccg actcatggag acgcgagata tttaggatct 964081 gaaagtgatg gacggactgc ggatcatctt tactttaaac aagtcgcgca ggcggcagac 964141 aggctgggat atacaggagt tcttctgcca acgggaagat cgtgcgagga cccgtggctt 964201 acagcgtcgg cactggcagg agaaacaaag gacttaaagt ttttagtcgc ggtaagacct 964261 ggtttaatgc agccttctct ggcagccaga atgacatcca ccctagaccg catttcagac 964321 ggccggctgc tgatcaacgt tgtggcaggg ggcgatccgt atgagctggc aggcgatggc 964381 ctgtttatca gccatgatga gcgctacgag gcaacagacg aatttttaac cgtttggcgg 964441 agacttttgc agggagaaac ggtttcctat gaaggaaagc atataaaagt ggaaaacagc 964501 aatctgcttt tcccgccgca gcaagagccg catccgccca tctatttcgg tggttcgtca 964561 caggctggaa ttgaagctgc cgcaaagcat acagacgtgt acttgacatg gggtgagccg 964621 cctgaacaag taaaagaaaa gatagaaaga gtcaaaaagc aagcggcaaa agaagggaga 964681 tccgttcgat ttggcattag gctgcatgtc attgcccgtg aaactgaaca agaggcatgg 964741 gaagcggcag agcgcttgat cagccacttg gatgatgaca ccattgccaa agcgcaggca 964801 gctttgagcc gttacgactc ttcaggccag cagcggatgg ccgtccttca tcaaggcgat 964861 cggacgaagc ttgaaatcag cccgaatctg tgggcgggga tcggcctggt cagaggaggg 964921 gcaggaacag ctcttgtcgg tgatccgcag acgattgccg accggatagc ggagtaccag 964981 gcactcggca tagaatcgtt tatattctcc ggctatccgc atttagaaga agcgtattat 965041 tttgcagagc ttgtatttcc gcttttgccg tttgaaaatg atcggacgag aaagcttcag 965101 aacaaaaggg gagaagcggt aggaaacact tattttgtca aagagaaaaa tgcatgagtt 965161 taactaaaat acagcccccc gaacatggta tgatattcaa aaaaaggggg ctttttttct 965221 gaaaacattg agaagcgcgg cagtcatttg cctcatagct atgctgtcag catgcggaca 965281 ttcaaaacag atggaaatca aagcggcgga catatcagat cttgaaaaaa acagaatgga 965341 tgtcgcagct tcacaggcat tcactgccga agccgtcaat atcggtgaag gtatttcttc 965401 agctgacatg tacatcgaac attatcaaaa gggaaagctt gttgagaggt ttggaccggt 965461 tcgtgcagat tattcagagg aaaaaactga taccatacaa tttgtttatt ttgagaatga 965521 agagggggaa ggaaagaata aacataccac cattcatttt ggcattgtgg ataaacaggg 965581 aactatagcg gctgattcat cggtgaaacg cgacgatagc acaacacagg aaatgactca 965641 gaatatttca tcgccggaac cgattacttt cgagaagcct gctttgatcg gcagcagtat 965701 tagagggact gacgagacaa tgcacacctc tgaacataaa aaagagctca ttaagcatca 965761 agatgcgtta ctgtattatg tggaattgca tcattagaat gggcggcttc aggccgtctg 965821 ttttacaaag cggtatgctt gcttttttga atggtgaatg atacatttta aatcgtaaca 965881 atttcgattt aaagggaggc tatgtgactt ggctaaaaaa tcaaaagtgg caaaagagtt 965941 aaaacgccaa cagcttgttg agcaatacgc tggtattaga cgcgagttga aggaaaaagg 966001 agattacgag gcactcagca agctgccaag agattcagca ccgggaaggc ttcacaaccg 966061 ctgcatggta acggggcgcc cgagagcata tatgaggaag tttaaaatgt ccagaatcgc 966121 tttcagggag ctggcccata aaggccagat tcccggtgtg aaaaaagcaa gctggtaaga 966181 aaaaactccg gccgattaca gcgcgccgga gtttttttcg tttttcttga aagagatgac 966241 gtaggaaagg tgctggatga tcatgatgat aaacacaata ataataggga aaaacggaat 966301 gcgcgattga aatagcggat aaaaaatgag aagaaccgct gcggcaggca gcgagaagta 966361 gacagcgata tatgacgcgc gacatgcttt tgccgtcatc atctgctctc tttcatcctg 966421 ctcttcaaac tcatcaggca gaagtagctg ctttctggca gggcggcttt ttttctgtaa 966481 gtacaaataa accgcagacg ccgcaacaaa cagaataaag ggagtgaggt ttaaatcaaa 966541 taccatcccg ccgctctttg tgccgaaaaa agatgctatg ccttctgagg cttcaaagta 966601 tgaaatcagc gcccagcatg caaggccaaa taaaacaagg tgaaaagctg cttttgtttt 966661 catgctcatc ttagttttcc tcctctaacc aaaagacatc ctccattttc atggagaagg 966721 ctttgcagat tttcagtgct aacagcagtg agggaacata atcgcctttt tcaatcgctg 966781 ccacagtctg tcttgtgacg ccgaccgttt ctccgagttt ttcctgagaa tagccgaagc 966841 gtgccctcag ctcttttact ttatttttca tcatgacgtc tgtccccttc acaatctcga 966901 ttgattatat tgtatagtat acttaacatt atgtaaatgg aacttaacaa ctttacaaaa 966961 agataacttt ttttcgacaa aatttttata ttcccttgac gaaaaataaa taaacatgta 967021 atataaaaaa agtcagagcg gtactgttgc tgacaatcac aaatgcgggt gtagtttagt 967081 ggtaaaacct cagccttcca agctgatgtc gtgagttcga ttctcatcac ccgctccata 967141 catacgttat taacgcagtg tttcgtttct cagataaacg aagtattgcg tttttttatg 967201 tgaaaaagaa cacggtattc gtgttctttt acgtaagcca atgtactgta tgggtgccgc 967261 cgtgaatttg ttcaaacatt ttcgttaatg atgataagag gttaacagcg ctgcttttct 967321 caatcgatgg cgggaaaaaa atgatttgca gcatattctt agtctcgttt gaaacgggat 967381 agtggttgac gctgtttttg aaatcgccaa aaatgccgtt ttcatcagag aaaagcagta 967441 tgttttcttt ttctcccaat gagatccgga ccggctcatg aagctttccg gcatcataaa 967501 tcataatagg cagagaatat tttaatgcga aaaaatcgat tgtgtcatgg gccgagtctt 967561 tactttccat gaattgttcc ttggatatcg ggaccagcat gtcctccatt ggggttgttt 967621 ctccctcaaa tgaagggtta agctgtttaa agagtttctg ccattccttg acgaaggatt 967681 catcggatat accgccgtcc gcatagtcga aaaacaagga ttcttgaaac aggcggagtc 967741 tgcctttcag catttgcggt gaggagccga cttcgatatt ctcataaatg acagcagctg 967801 catgtaagcc ggccgcacgt tcagtaataa cagaatcaag tttgatattc actagcattc 967861 actccagtta cgtgatatca acctattata aacgctgtgt cgttttatca caaagaaagg 967921 aggctgtgca aaacatgaac gtttatcagc tcaaagaaga attaattgaa tacgcgaaaa 967981 gcattggcgt agacaagatt ggttttacga ccgctgatac ttttgacagt ttaaaagacc 968041 gtttgattct tcaagaatca ctcggctatc tctccggctt tgaagagcca gatatcgaaa 968101 aaagggtgac gccgaagctt cttttgccga aagcgaaatc aatagtggca attgctctcg 968161 catatccttc cagaatgaag gatgcgccga gaagcacgag aactgagcgc aggggcattt 968221 tttgcagagc ttcctgggga aaagactatc atgatgtgct gagggaaaag cttgatctgc 968281 tggaggattt tctaaaaagc aagcatgagg atatcagaac gaagtcaatg gttgatacag 968341 gtgaattgtc tgatcgcgcc gttgcggaac gtgccggaat cggattcagt gcgaaaaact 968401 gtatgatcac aacacccgag tatggctctt atgtgtattt ggcggaaatg atcacaaata 968461 tcccttttga gcctgatgtg ccgattgaag atatgtgcgg gtcctgcacg aaatgcttgg 968521 acgcctgccc aacgggagca ctggttaatc ccgggcagct taatgcgcag cgctgcatct 968581 cttttctgac ccagacaaaa ggatttttgc ctgatgaatt ccggacaaaa atcggaaacc 968641 gcctgtacgg gtgcgatacg tgccaaacgg tatgccctct caataaaggg aaggattttc 968701 atcttcatcc ggaaatggag cctgatcctg agattgccaa accgttattg aagccgcttt 968761 tggccatcag caatcgggaa tttaaggaga aattcgggca tgtctcaggt tcttggcgcg 968821 gaaaaaaacc gattcagcga aacgccattc tcgcgcttgc ccattttaag gatgcttccg 968881 cactgcctga attgacggaa ctgatgcaca aggatccgcg tcctgtcatc agggggacag 968941 ccgcatgggc aatcggaaaa atcggagacc ccgcctacgc ggaagagctt gaaaaagcgc 969001 tggaaaaaga gaaggatgaa gaggcaaagc tggaaattga aaaaggaatt gagttgctaa 969061 aagcttcagg catgactaaa caaggcctgt cctgacatac gtatagagca gaaggaaaaa 969121 acacttgaga tcatccaagt gttttttctc tataaaaaag tatggcgggt ggggtgagct 969181 tgaagtacat tttagaacaa ttagcggagg agcggctggg ctttctggtt aacgggcatg 969241 ctatgagaca ggagtctcaa gtcggagacc ttaaagtcat ggagcgtaag aaaaagcttc 969301 tggaaaaacg taaagttgac atcataaaag cgaaagcaaa ggccgtgatt aatcatgtgc 969361 gggttgagga tgacggaacg acctgccttt cgtataccat ccattacgaa tacgtgtgta 969421 aggaacaaga tgacagcttg tatatagaag agcacataga ggagcgaatg gctttcctgt 969481 atgatcacat tttgattagt gatcaggaaa ttgcgaaaaa gccggctgga tttcatgaag 969541 ggaccagtat tattgactat tctgaagctg aagaggaaag agaagcgttt ggcagggctt 969601 ttcaatacga tcgtctcggc gctgtccaat atgccgagaa attttggaac aagcgcaatc 969661 ctgcttataa aaatttcagc gataactgta caaattttat ttctcagtgt cttcatgcag 969721 gaggcgcgcc gatgcgcggt catccgaaca ggggatcagg ctggtggatg aaacaaagct 969781 catggagcta cagctggacg gtggctcact ctatgaaaat gtatttgtcg aattcaaagg 969841 ccggactgcg tgcggtgcgg gtgaaatcag cggaagaact gatgccgggc gatgtgattt 969901 gctatgactt cgaaggagac ggccggttta atcatacaac gattgtcgtg gcaaaggaca 969961 aaggcaatat gccgcttgtc aacgcccaga cttatgacag caggatgagg tattggtcat 970021 atgaggattc tacggcatac acgccgtcaa tacgatatgc cttttttcat atcgttgatg 970081 atacgacaaa agagtaatta atgttataat gatgggcgga taagaaaaac agaggtgaac 970141 attgtggcat tacatgtcgt tttatatcaa ccagaaattc ccgctaacac agggaatatt 970201 gcacgtactt gtgcagcaac caatacaacg ctacacctga ttcgtccgct cggcttttca 970261 acggatgata aaatgctgaa gcgtgccgga ctcgattatt gggagtttgt taacgttgtg 970321 tatcatgatt cgttagaaga attgtttgag gcatataaaa aaggcaagtt tttctttatt 970381 acaaaatttg gccagcagcc tcatacatca tttgattaca ctgatcttga cgaggattat 970441 ttcttcgtgt tcggaagaga aacaagcggt ttgccaaagg atttaattca aaataatatg 970501 gaccgctgcc tgcgtcttcc gatgacagag catgtcagat cgttaaatct gtccaatact 970561 gccgcgattc ttgtttatga agcgctgcgc cagcaaaatt accgtgattt aaaatagtga 970621 aaaacccgct catcgatgat gggcgggttt ttttgcggat gttgaaatgc tttgtttcgt 970681 ttttgggctt aacaacgtaa cagtgttatg ttacaatgta cccatcaaag gagctggact 970741 tatggaagaa caattaatct ctaaaaaaga attacttgaa agaacatcga tttcatacgg 970801 tcagctgtat cgatggaagc ggaaaaactt aatacctgag gaatggttta ttcgtaaatc 970861 cacatttaca gggcaagaga cgttttttcc gagagaggag attttaaaac gtatatcaat 970921 gattcaaaag atgaaagaaa atttgtcttt ggatgaaatg agggaaatgc tgtcgccgaa 970981 aatgaaggat gtcagcatga ccgctgatga attgcttcat aaaggtttgg tttcaaggcc 971041 tgctcttgaa gcctattcag aagacggagg aagtccggtt ttttcatcca gcgatttgct 971101 ttcgctgttt gtgcttgagg gcctgctgca gtctggaaat gtcagccttg cagaagcaaa 971161 aatggctgca gaggtattaa agaagcatga tactgaagag attgaaaaac agacggagct 971221 gattgtgctc cgcaagctcg gtgtcacaac ttgttttata gcggctgcgg cggacagcat 971281 tttgtttgaa tcatccgtaa aggttgtgga acgggtagat ttattaaaag cttcagagga 971341 attaaaaaca acatttatgc aggagggcca tcaatggatg tagtggaaaa gctggtgata 971401 aatggatcag gaagttctaa gggaggaaca tttcaatcag ttgagattaa tggcagcggg 971461 acagtggccg gggacgtgga gtgtgacact ttttctttta atggaaacgg aaaagcggac 971521 ggcagcgtca aagcgaaagc ggtaactatc agcggttcag gaaagataca tggagacgtt 971581 gaagcagaat ctatccggat gaatggcact ggttttattc aaggagaggt atctgcaaaa 971641 caattgaaaa tcgctggatc atcaacattt ggcggcactg tcaaggctga tggaattgac 971701 attagcggaa aagctgtcat ggaagcagat tgtgaaacag aaacctttca atcagaaggg 971761 aaatgcaaaa tcagcgggct tttaaatgca gaccaggtga tcattaagct ttctgcaggg 971821 gaaagctatg cgcgggagat cggctgccgc catcttcaag tgacctgcag aaaaggaatg 971881 ctgacattgc tcagattgat gccgcagcct gttctaacag cagagctgat cgaaggtgac 971941 gtgattgaat tgacaaatac aaaggcgaaa accgtgcgcg gtaataaagt gatcatcggc 972001 ccggattgcc agattgaaac cgtcgaatac agcggggact atacctgtga tccaagcgcg 972061 tcggttgaaa catccacaaa gttgtaagga ggatcgtaat ggagacaaca aaactgggaa 972121 atttaaaatt atatggcgct gggcatgccg caggaggcgc gtatcacaat gtcagcatca 972181 aaggagaagg tatagttgga gaagggctgt ctgctgtagg ctgccgcata tacggaacgg 972241 gcctttttct cggaaaagca gagactgagc ggctgcgtgt gctcggagaa agtgaatgta 972301 aaggcgatct gacagccggc aaaatcaata tatatgggac aatgaaagtc agcggctcac 972361 ttcaatttga tcgattcaat ctgaaaggcc agactgaaat tggcgggaat atgactggag 972421 aatcctgcga tgtgaaaggg aagcttagcg taataggtga ttgtgaaaca gaaatgttcc 972481 atgtcacagg ctgtgttgat gtatcggggt tattaaattc gggtgagatc aagctgggat 972541 tgagccatga tataagccat gtgcaggaaa tcggcggaac aacaattaca gtgaaaagac 972601 gcgcgagttt ttttagccgg aagaaaggga agctgatcgc cgatgtcata gaaggagatc 972661 gggtttattt ggagaatacc gaagcggcag ttgtcagggg aaaagaagtg atcatcgggc 972721 cgggatgcag catcggaacg attgagtacg aatacaaatg tgaatgcgat ccgcattcac 972781 agattaaaga aaaaacaaaa ctgtaaaaca ttgttctgtt atacaaaaag ggtgctcttt 972841 caggagcacc cttttttatt cttttccagg cttgctttcg tatcctgcgg taaaaattga 972901 tactaaaaaa gtgacaatga cacccatcat gatgattgtt ttcaccgtct ctccccctct 972961 tcaatttttc cgtgctgtcc gagtctggat gattctgtat ttttctttat tatgaacggt 973021 cgcagtctgc cttgtcaacg atgtatgagt atctttattt ttaagaaacc aaagcatgta 973081 tcacgagatg gcggcataga ttgtatcaaa gtaccttatt tgcatagtgt atcaaacatg 973141 atagaggagg tccttatgga tatattaaag aaaattgaaa agtacagaga ggaagagcag 973201 cggctgaaat gggaaggaac tttcgccgat tatttggaga ttattaaaga aaatccgatg 973261 gtcgcgcaat ctgctcattc tcgagttttt aatatgataa aagacagcgg gatagaggag 973321 attgacggac gcaagaagta cagttttttt gaccgcgagc tgttcgggct tgaagaatct 973381 ctggagcgtc ttgtggaaga gtattttcat ccggctgcca aacgtctaga tgtcagaaag 973441 cggattctat tgctgatggg gcctgtgagc ggcggtaaat ccacgctggt cacaatgctt 973501 aaaaaaggtc tcgaagcgta cacgctgaca gataatggcg ctgtatatgc gattaaaggc 973561 tgcccgatgc acgaggaccc tctacattta atcccccatc atttacgcga tgacttttac 973621 agagaatacg gcattagaat agaaggaagt ctttctcctt taaatgtcat gaggctggag 973681 gaagagtacg gaggaagaat tgaggatgtg aaggtggagc gcatcttctt ttcagaagat 973741 aagcgtacgg gaattggaac attcagtccc tctgatccga aatctcagga tattgccgat 973801 ttgacgggga gtattgattt ctcaacaatc gccgagtacg gttcagaatc agatccgcgc 973861 gcttatcgat ttgacggaga gctgaataaa gcgaaccgcg ggatgatgga gtttcaggag 973921 atgctgaaat gtgatgagaa atttctctgg catttgcttt ccttgacaca ggaagggaat 973981 tttaaagctg ggcggtttgc gttaatttct gctgatgagc tgatcgtggc tcacacgaat 974041 gaaacggagt atcgctcatt tatttctaat aagaagaatg aagccctgca ctcaagaatc 974101 atcgtgatgc cggttcctta taatttaaaa gtgtctgagg aagagagaat ttatgaaaaa 974161 atgattgcag aaagcgatgt ggcggatgtt catattgccc cgcatacgtt gaaggtcgcc 974221 gcgatgttct caatccttac ccggttaaaa gagccgaagc ggtcggatat tgatctggtc 974281 aagaaaatga gactgtatga tggggaaagt gtggaaggat ataactctgt cgacgttgag 974341 gatatgaaaa aagaatataa tgatgaaggc atgagcggaa ttgatccgcg gtacgtgatc 974401 aaccggattt cttcaacgat tatcagaaaa aatatggaat cgattaattc tctcgatgtc 974461 cttcgctcct taaaagaagg tcttgatcag cacccatcaa tttcaagcga ggacagggag 974521 cggtatttga attttatctc tgccgcccgc aaggaatatg acgatattgc gaaaaaggaa 974581 gttcaaaaag cgtttgttta ttcatatgaa gaatcagcaa aaacacttat ggacaattac 974641 ctcgataacg tagaggccta ttgcaataaa aacaagcttc gtgatccttt gacaggagag 974701 gaaatgaacc ctgacgaaaa gctgatgaga tccatcgaag agcagatcgg catttcggaa 974761 aacgccaaaa aagcgttccg cgaagaaatt ttaatccgca tctcggccta tgcgagaaaa 974821 ggcaagcggt ttgattacaa ttcccatgaa agactgcgtg aagctattca gaaaaagctg 974881 tttgctgatc tgaaggatgt cgttaaaatt acgacctcaa caaaaacgcc ggatgagcag 974941 cagctgaaaa aggtaaatga agtcgtggcc cgtttaattg atgagcacgg ctacaactcg 975001 acgagcgcca atgagctgct gaaatatgtc ggcagcctgc tgaaccgata agcaacgtga 975061 cccgtccgaa tagggcgggt tattttgtcc cattttctaa atagtttgtc aattaaacgt 975121 gcatatgtgc atatgatgaa tataaatctt ttcaaaagac ttgtttcata atctggcaca 975181 agccggaata cgtatgtatc acgaccacaa atggttaagg aggggaattc atgtcccaaa 975241 atgacagcgg ccattttttg atttctgagg aaaactggtc cctccatcgc aaaggcttcg 975301 atgaccagca gcgccaccag aaaaaagtgc aggaagcgat caaaaacaat cttccggacc 975361 tcgtaactga ggaaagcatt attatgtcta atggaaaaga tgtagtgaag atcccaatcc 975421 gttcacttga tgagtataaa atccgttata actatgataa aaataaacat gtagggcaag 975481 gagacggcga gagccaggtt ggagatgttg tggcccggga tggatcagac aaaaaacaag 975541 ggcctggaaa agggcagggt gccggtgatc aggcaggcga ggattattat gaagcggaag 975601 tttcattaat ggatttagaa gaagcgcttt ttaaagaatt agagcttccg aatctccagc 975661 aaaaagagcg ggacaatatc attcatacag atatcgagtt taatgatatc cgtaaaacag 975721 ggttaaccgg taatattgat aagaaaagaa cgatgatgtc agcctttaaa cgaaacgcaa 975781 tgtcaggaaa accgtcgttc tacccaattt atccggagga cctgaaatat aagacgtgga 975841 atgacatcac aaagcccgaa tcaaaagccg tcgttttagc catgatggat acaagcggca 975901 gtatgggggt ttgggaaaaa tacatggcca gaagcttctt tttctggatg acccgttttt 975961 tgcggacaaa atacgagact gtggaaattg aatttattgc ccatcataca gaagcaagag 976021 tggtctcgga ggaggatttt ttctcaaagg gagaaagcgg cggaacaatt tgttcttccg 976081 tatatcggaa gtcgcttgag cttattgatg aaaagtacaa tcccgcccgc tataacattt 976141 acccgtttca tttttctgac ggtgacaacc tgacatctga taacgcgcgc tgtgtgaagc 976201 tggtcaatga tattatgaag aaggccaatc tgttttgcta cggcgaggtc aatcagtaca 976261 acaggcattc aacgttaatg tctgcatata aaaatgtaaa agatgagaaa tttaagtact 976321 atattttaaa acagaaatct gatgtttttc aggctctaaa gaactttttc agaaatgaag 976381 agtctggtgt aagccatcaa ttttcgtaat gaaaagccca tttcagggct tttttttatt 976441 taataaaagc aagaaaacgc ttgcgaaaaa aatacgggag aaaaagaaat ttttcctttg 976501 acaaatcttc tttcatttat taatatttta tcttgtgaac tattattgag gaatgaggtg 976561 aaaaggagtt gactgaatca gaacgtgctt tgctcacttt tgaacagctc ttcgatacgt 976621 ctcgggcgat atataaaaaa cagaagaaga tattggagat tgtgcttgag ccttttgata 976681 ttacagtcct tcaatatttg ctgatgttta aaattcatca aagcggaagc accccgctaa 976741 gcaagctggc aatgtcgctt gatcttaagc ctgcttctgt gacgcggatg acagatattc 976801 tgtataagcg ccaattgatg aatcgatatg acagtccgga tgaccgccgt atcgtcatga 976861 ttcagttaac cgaagagggg gaagaactga tagaaaaagc cgctgtgcaa tatgcaaaaa 976921 tgggtgctgg cttgtaccaa aagcttgata cctcccagct gcagtatttg cgcaaactag 976981 ccggaagttt aacgaagctt gctgaaggct gttcagaaaa aagcggtaat taaaaacttc 977041 tcacatattt tcaccagctt tccgcaaaat gatagaggat gaaacgaaag gagaaaacaa 977101 aatgaacaga ggacgtttaa ttctgaccaa cattatcggt ttgattgttg ttcttgcaat 977161 tatagctgga ggtgcttact actattatca aagcacaaac tacgtaaaaa cagatgaagc 977221 aaaagtagcg ggcgatatgg ctgctattac tgctccagca gcaggtaaag tatctgactg 977281 ggatctggac gaaggaaaaa cagtgaaaaa aggcgacaca gttgcaaaaa tcaaaggtga 977341 acaaactgtt gacgtaaaat ccattatgga tggcacaatt gtgaaaaacg aagtgaaaaa 977401 cggacaaacc gtacaagctg gtacaacaat tgcacaaacg attgacatgg acaacctata 977461 catcacagca aatattaaag aaacagatat tgcggatatt gaagtaggaa atagtgtaga 977521 cgtagtagtt gacggagacc ctgatactac atttgacggt actgtagaag aaattggtta 977581 tgcgactaac tcaacttttg atatgcttcc ttctacaaat tcaagcggaa actacacaaa 977641 agtaacacaa aaagttcctg tgaaaatttc aatcaaaaac ccatctgata aggtgcttcc 977701 tggaatgaat gcatctgtta aaatttctga gtaaaacaga tcagtcatca aaccatgaaa 977761 ggaggttgtc ttagatggct acaggcaaag aaaaaaatgc aaaaaaccct atgtcattgc 977821 tgattgtgct aatggcgggt ttatttttgg caattctaaa ccaaacactg cttaatgttg 977881 caatgccgca cttaatgact gaatttggcg taagtgcaac gacgattcag tggctgacaa 977941 caggttacat gcttgttaac ggtgtattga ttccgttatc tgctttcctg attacacgat 978001 ttggccagcg gagtctcttt ctcgtcgcga tgttttgttt tacgctcggt acgttagtct 978061 gcggtatcgc acctaacttc tctacaatgc tgatcggccg tttgattcag gccgtgggcg 978121 gaggtatctt gcagccgctc gttatgacaa ccattctgtt aattttcccg cctgaaagca 978181 gggggaaagg aatggggatt ttcgggctag cgatgatgtt tgctccagcg gtcggcccga 978241 ctctttccgg gtggattatt gagcattata catggcgcat tatgttttac ggacttgtgc 978301 cgatcggcgc aattgttatc attgtggctt tcttcatctt taaaaatatg gtggagccgc 978361 aaaaaatcaa actcgatact cttggcgcaa tcctctcgat tgtcggattc gcctccttat 978421 tatacggagt cagtgaagcc ggatctgacg gctggaccga cccgattgta ttgtctacag 978481 ttattatcgg agccattgca attgttgctt ttgttgttca gcaattgcgt catgatgatc 978541 cgatgcttga tttcagagtg tttaaatatg acattttctc actctcgagt gtcattaata 978601 tcattattac agtggcactt tacactggta tgttcctttt accgatttat ctgcaaaacc 978661 tggtcggctt tacggcgctt caatccggtc tgcttctgct tccgggtgcg atcgttatgc 978721 tgattatgtc accgatctca ggtattttgt tcgataaatt cggaccgaga ccgcttgcga 978781 ttatcgggct tctcgtgaca gtggtaacaa cgtatcaata cacgcaattg acaattgata 978841 caccatatac acacatcatg ctgatctatt caattcgtgc atttggtatg tctctcttaa 978901 tgatgccagt catgacagcc gggatgaacc agcttcctgc ccgtctgaac agccacggaa 978961 cggcgatgag taacacgctt cgccaaatca gcggatcaat cggaacaagt ttaattacga 979021 cgatttatac aaaccggacg acattccatt attcacaaat tgcagataaa acaagcacgg 979081 cggacccgaa cttcctccat gcgttccaaa atgcagtttc gaatttaatg gtgaatatga 979141 atgtgtctta tgatacggcg aaaacatatg tgtactcaca tatttataaa cacgcatcac 979201 tcgattccaa tgtcatgggg ataaatgatg cctttatgtg ggcaacctta ttctgtgtag 979261 caggtttgat tttaagtatc ttcctgcgtg acgtcagaaa agataaattg cgtaagaaga 979321 aaaaagagga gctttcatta cttcctgctc caaaagaagc taaggaatct taatctgtac 979381 agggaggttt cctgaatgaa aatttatgta gtgtatgata gtgaaggcga acatactaaa 979441 gtgcttgcag aagcgattgc tgaaggcgcg agagaaaacg acgcggctga agtgttcatc 979501 gaccatgtag atcaggctga tatccgcaag cttaaagata tggatgcgat tatttgggga 979561 tgcccagggc atttcggaac aatcagctcc ggtcttaaaa cttggatcga cagacttggc 979621 tacttgtggg ctgaaggcga gctgatcaac aaagtcggtg ctgtcttctg cacaacggca 979681 acaacacacg gcggcttgga aatgacaatg cacaatttaa tcacgccgat gttccaccaa 979741 ggcatgattg ttgtcggact gcctggcaac gtgcctgaaa acgcacttta tggctcttat 979801 tacggagcag gtgtcacttg tccggtagac agtgatgagt taatgtctga ggaaggtatt 979861 cagcttggac gcgcgttggg aagacgtgtc agccaagtca caggaaacct aacagcagga 979921 cagtaaggag aggttgaaat ggccattatt atagcaataa ttgctgctgt cattgtcatt 979981 gcggccctta ttacatttaa cgtccgcaac gcctcacctg gacctgagaa gcaagaagca 980041 accgatagaa tcgcacctcc agaagaggaa aaaaacgaag cgcattaccc tgctgaagca 980101 agggctgccg agcatacgcc atccgttgtc aaaaacgatt ctccaaaaga gaagcgtgac 980161 acaatgggtg atgatattta caggcaggcg ctgcaaaagt ttaagcattc tgatgaagtt 980221 catgcagaag aagaggtcac tgaggaaagt gacaaaatgc aggaccgcag ctatcgtgat 980281 gcgctgctct ctatgaaaaa taagaaaaag taatgaaaaa ggcaaatccg tttactcatg 980341 cgggtttgcc ttttttgctg tttccatcaa ttatgttttt atcaaataaa tccatggaat 980401 atgttgtatt ccaccttgat ctagtgtact atgttactca tacaccgagg attttttccg 980461 ggaggtaaag acatgaattc ttttttaggt ttattaaaga aagatatcaa gctttcaaga 980521 atgtggctgc tagtatggat atgcggaatc attttcttat tgggaacagg ccatattata 980581 gcttctcgca cgaaagaacc tctagtcatt tttggttttt ttgttgcagt tgcttttttt 980641 ctgcttttct tatctcctgt ttttgttttt tatcaccttc gcaaggaagg gaaatcacag 980701 ctttggctgt acaatccaaa tggcggctta tggctgtttt cttctaaatt ggcagcatct 980761 ttgctctatc aatttgtgat tcagttggca ttaacagcct atggcatatg gatgtatcat 980821 atgctctctg taaaaaatct gctggagcat caagttgata taacgagtac agtggctttg 980881 ctgaatatgt atgggcttat ttcttcgtta gatatgtcag taacagtcat tgtgttttgg 980941 actgtttttc actctctcag aaattggcgc ggaatgcggt gggctgcgat ggttctgttg 981001 gtcgcaatgt ggttattctt cgatgaatac atcataagcc ctttggttga atctcaaaag 981061 catttctggc ctgtaacagt ctattgcaat tttgatttcc acttccacaa tgtttggaga 981121 ttggaactaa aacctatcca tctgtctgtg ctagggtttc ctattgctat agtcatcaca 981181 ttcttgctgc tcatcatggc ttcaaaactg cttgatcgta aagtagaggt gtaaatatgg 981241 acaatcaatt ccaatcctcg aaaccgattt atctgcagat cgctgatcag atcttttata 981301 ggctggtcag gaaggagctg ctcccaggag acaagcttcc ttcagtaaga gaaatggcga 981361 ttcaaactaa agtaaatccc aatacaattc aaagaactta cagtgagatg gaaaggctgg 981421 gtattgtgga gacaagaaga ggtcaaggga cgtttattgc ggaaaaagca gaaatcgtag 981481 acgagctgaa agacaagctg acacgagagg tgctggaagg ctttgtcaag caaatgaaag 981541 agctggggct aacgaaagaa gaaatgttag aagggattaa aacattcaca gagggaggct 981601 aaaatggaaa tcaagctaga acatgtatca aaaaaatacg gccgccatac ggccgtcaat 981661 gatgtgtcaa tcaccctatc atccggacgg atttatggcc tgattggacc gaacggcagc 981721 ggcaagtcaa cgaccctgaa aatgatggct ggccttctgt ttccgacttc aggatttgta 981781 aaagttgatg aagagcaggt tacgagagaa atggtgcgtc aaacggctta tcttactgag 981841 cttgatatgt tttatccgca tttcactgtt aaagatatgg tgaattttta tcagtcgcag 981901 tttcctgatt ttcatacaga acaggtttat aagctattga atgagatgca gctgaatccg 981961 gaaaaaaaga tcaaaaagct atcaaaagga aatcggggca ggctgaaaat cgttcttgct 982021 ttagcgagac gggcagacgt catcttgctt gatgaacctt tttccgggct tgatccgatg 982081 gtcagggatt ccatcgtaaa cagccttgtg tcgtacattg attttgagca gcagattgtc 982141 gtgatcgcga cacatgaaat tgatgaaatt gagactttgt tagatgaagt aatcatcctc 982201 gccaatggag aaaaagttgc gcagcgtgaa gtagaagata ttcgtgaaca ggaaggcatg 982261 tctgttttgc aatggtttaa atcaaaaatg gaagtttgct agaaagagga ggaatatgat 982321 gaaaacagtg ttggaattga aaaacgtgac taaaaacatc agaggccgaa cgatcattga 982381 tgatctcagt tttacgattc gtgaaggcga ggtattcggt tttttaggac caaacggagc 982441 ggggaaaacg acaaccatcc ggatgatggt ggggttaatg aagctgtcga aaggtgatgt 982501 cctcatttgc ggccaatcaa ttacgaaaga atatgccaag gcgattaagc atatcggagc 982561 gatcgttgag aatcccgagc tgtataaatt tttgagcgga tataaaaatc tccagcaatt 982621 cgcaaggatg gtcaagggtg tcacgaagga aaaaattgat gaagttgttg aactggtcgg 982681 tttaacagac agaatccacg acaaggtgaa aacatattct ctggggatga gacagcgtct 982741 tggcttggca caatgccttc tgcacgatcc gaaagtgctg attttggatg aaccgacaaa 982801 cggccttgat ccggcgggga tcagagaaat cagagatcat ttaaagaagc tgacccgaga 982861 aagaggaatg gctgtcatcg tttcaagcca cctgctgtca gaaatggaac tgatgtgtga 982921 tcgaattgcg attctgcaaa aaggaaagct gatcgatatt caaaatgtaa aagatgaaaa 982981 cattgatgag aatgatacat atttcttcca ggttgagcag ccgagtgaag ccgctactgt 983041 tttaaatcag tacgatttgc tgagtaagac aaatggtgta gaaatcaaac tggctaaaga 983101 ggaagtccct gcggttattg aattgctggt gatgcagcaa atccgtattt atgaggtcaa 983161 ggtcataaca aaatcattag aggaccgttt cttagaaatg acaggtgaaa caaaagagga 983221 ggttcagcat gcttaatttg atttataatg agtggctcaa aattttcagc cgtgccggaa 983281 catgggtgat gatcggaatt ctggggctga caatggttgg atttgcattt ttggcgaatc 983341 atttttctgc cggtgaatca aattcccatt ggaaacaaga gcttcaagca caaaacgccg 983401 aattaaagaa agaaatcaaa gaagatcctt cactgaaaga tgggtataaa gaaacaatca 983461 cactcaatga ctatcgcatc gagcataata tccctagtga cacgggctat acggtatggt 983521 cttatgtaac ggattcagca aactttacca tccttaccgg tctgtttact attatcatcg 983581 cggccggaat tgtcgcgaac gaatttaatt ggggaacgat taagctatta atgattcggc 983641 cgctcagtcg ttttcaaatt ttgatgtcca aatatattac agttctcctg tttgggctcc 983701 tgttgctgtt gattttattt atcggttcta ctttattagg gttgatcttc ttcggaacgg 983761 gtggtgaaac cgccgcgaat attcatttaa tctataagga tggccatgtc attgagcaaa 983821 acatgatggg gcatttggct acaacgtatc tttctgaatc cgtctcggct ttaatggtgg 983881 cgacgatggc gtttatgctg tctgcggtat tcagaaacag ctctcttgcg gttggttttt 983941 ccatcttctt gttggttgcc ggtacgactg caactgcatt tattgcagcg aaatttgact 984001 gggcaaagta tatattgttt gctaatgtcg acttgactca gtatgtggat ggcacaccgt 984061 taataaaagg gatgactatg acgttttctc tcgtcatgct ggcgatctac tttatcatct 984121 tcctgttgct tgctttcgga atcttcatga agcgggatat tgcaaactaa taaaaaaagc 984181 tgttttgctt atgcaaaaca gcttttttgt caaaataaaa actgcaggtt tgcacctgca 984241 gtttttcata tcaatttatg cttacgcttc tttagtaacg ttagcagctt gtggtccgcg 984301 gtttccttca acgatttcaa aagaaacagc ttggccttct tctaaagttt tgaagccttc 984361 gccttgaata gcagagaaat gaacgaatac atcgtcttga ccttctactt cgatgaatcc 984421 gaaacctttt tcagagttga accattttac tttaccttct aacatgaaat ttcctcctaa 984481 agcgatcata acgcttaaat tcactattct tgctcttaac aaactttcaa gacgaaaact 984541 cttacaaaac tttcttctta aagatagttc gaacaaaaat aattaccttt actctaccag 984601 taatcttcag aaaaaacaac tgcttattga aatttttttc ggaaaatacc atatttattt 984661 ttcaatttga tatttattta cggaaattca tctgttttct cgatatgtga tcatacgttt 984721 gccttagtat tccttcattt tgggaagata agtaatagga attgacaacc ttattggata 984781 tgagtaaggt aaaagttaat caatattaca aatgacaacg tttatcaact aagagagcgt 984841 atgattttta tgtctgatat tgcttgcatg ctctaataca tagataggag tatggtcaca 984901 atgaaaaagt ggcttatatg cagtttcgtc cttgttcttc tcgtttcatt tactgcatgt 984961 tcaccgtctg cagaacatga atcgataaaa atcgggattg ctgagtctga cggggcaata 985021 tggaactata ttgctcaaaa ggctgaagag gcagggctgg atattcagct gatccctttt 985081 tctgattatg cggagtctga tatcgcactt gctaacaaag aaattgatgc caacgccttt 985141 caaaccattt catattttca gtcgttcact gaaaaataca aacttaattt ggcaccgctc 985201 gggacgacat acataacgcc catgggcatt tattcaaaac gatatgaacg aatccgagat 985261 atatcgcggg gagctgtcgt ttctgttccg gataaagcgt tcgattttgg cagggcgctt 985321 acggtgctcc aggaagcggg tttgctaacg ctgaaaaacg gatttaacgg aacaggttca 985381 gttgatatga ttaaagataa tccgagacac ctgaaattaa aagctgtccg gcaacaggat 985441 gcagtgagcg gtgccgacgt gtttgtcatg aaaccatcag aagcaaaaaa agcgggcttg 985501 aacccgaaaa agcatacgct aaagagcggc ggactcatgt ctgaggaaga gatgaatttg 985561 attgttgtca gagcggagga tcaagatcgg gaagcgctgc aaaccattct tgagctttat 985621 caagctgatg atacagcggc atttatagaa aaagaatatc agggagatct tgtcccggct 985681 tttctgcctt tgaaacgtct ttcagattgg aagaatgaat tcgaacattg aattcattct 985741 tttttttctg aaaaacacac tctgttccgt cccgtttctt tcgctttgta aagcatttga 985801 tcggcaagaa tgggcaagga tcctggctgt tccgtattat tggggtaatg agcggcccct 985861 agtgatatcg taactgaaag ctcgtcgccg tttgttaata caatcggtgc atcacttaca 985921 gtgctcctga tccgttcagc gatccgggct gctttatcaa gagaacagtt cggcaggagc 985981 acggcaaatt cttcaccgcc gatccgagcg gcaggatcag tatttcggat ggtctgcttc 986041 agacgtaacc ctagctcttt gagcacctga tctccttcat gatggccata ttggtcattg 986101 atggtcttaa aatgatcgat atccatataa atcagtgcaa attgaaaatg cggggtatcg 986161 gccgcctgct gatacagagc ttttgtggtt tcttcaaatt ttcttcggtt atacacgcct 986221 gttaaaaagt caaagtgcgc ctgaaactta tattgtttaa aaagaagatg tgcatttgtt 986281 tcatgatcaa taatatataa actgagcatg ccgcccgcta ttgatatgat ccaaaaatac 986341 aaatgaagtt cgtatgaatg taaatctata agaaaataaa aggaaaagga gatcaagcta 986401 tttgtgatta ttaaaagata gaaagcatgt tttagttgaa ctttttttct tctagaaaca 986461 atgagtgacg gaatggcagc gatacaaatg ataataaccg agtatagtgc agatgtgttc 986521 atcgtaatca gcaagcggcc tgcagtgatc atggccaggg ccgttgccgt tgaaacccag 986581 cctccataaa gagcggcaat cataataggg atatttcgaa gatcaataat tgaatgctga 986641 taggtaaatc caaaaaccat cagaataacc ccgagcaaac cgcaggccag tcctttaaca 986701 gcttgaaagg atatgctgtc ttttttatgt actagccttt ctttaaacag gtgggtgaag 986761 agataattaa atgtgattaa aatggtcaaa tttacaaaca gttctttcag caaatattat 986821 cacccttata taaggtacta aagatggaag ggaaagaaaa gaacaaaaaa ggcattatat 986881 aaggtttttt tacttgaatt gataagttaa aataattcgc acttgaccca tcggaattag 986941 tgtaatatag taaatgagaa aatttgaagg gagagtttac ctgctttgga gactttactg 987001 gttgtattac atgtatttat tttattttta cttatcttag ggctctttgt tatgcagaaa 987061 aaacatgttt ccttctctaa acgtgtattt actgcgctgg ggctggggat tgtattcgga 987121 tttgcgcttc agctgattta cggcccgact tcaaatatag tcattcaaac agccgactgg 987181 tttaatattg ccgggggcgg atatgtcaaa ttgcttcaga tggttgtcat gccgctcgtc 987241 tttatttcga ttctcggcgc ctttacaaag ctgaagctga caaaaaatct tgggaaaatc 987301 agcggtttga ttatcgggat tttagtagca acaacagcag ttgctgcagc tgtcggtatc 987361 gcgtccgcgc tttcatttga tctgcaggcg attcaggttg accaaggaag tacagagctt 987421 tcacggggac aggagcttca gcagaaatca gaggatatga cagcgaaaac gctgccgcag 987481 cagattgttg aactgctgcc tggaaacccg tttttagatt ttacgggagc tagaccgact 987541 tcaacgatcg ctgtcgttat ttttgccgct ttccttggag tggcattcct cggcgtaaaa 987601 cacaaacagc cggaacaggc agaaacattt aaaaaactgg ttgatgccgt ttatgccatt 987661 gtcatgcgtg ttgtcacact cattttgaga ctgacgcctt atggggtgct ggccatcatg 987721 acaaaaacaa ttgcaacgag tgatcttgac agcattctaa aactgggcat gttcgtgatt 987781 gcatcatatg ccgcgttaat cactatgttt atcattcatt tgctgctgct gacgttcagc 987841 ggcttgaatc cggtgattta tttgaaaaaa gcggtgcctg tacttgtatt tgcatttacg 987901 tcaaggtcta gcgcaggtgc tttaccgctg aatattaaaa cacagagaag catgggtgta 987961 ccggagggaa tcgcaaactt tgccggttcg ttcggtcttt cgatcggcca aaatggatgt 988021 gccggcattt atcctgcgat gctggcgatg atgattgctc cgactgtcgg ccaaaatcca 988081 tttgacccgg tgtttattat cactgttatc gcagtcgttg ccatcagctc cttcggggtt 988141 gccggagtcg gcggcggagc gacattcgcg gcgcttcttg ttttatcatc attaaacatg 988201 cctgtcgcgc tcgccggttt gttaatctca attgaaccgt taatcgacat ggggcgtact 988261 gctttgaatg tcagcggaag catgacatcc ggtcttatta caagtaaggt cacaaaagaa 988321 attgatcaag gggcatttca tgatcaatcc agagtgattg aagctgaaga agcgtaacat 988381 atgaaaacgt gtaatccaag aggattacac gtttttttaa cggccaggct ctaagtcctc 988441 cagcatttcc atcatcgtgt tgtcgtccat gacattcatt gcgttttgtt caaaatgaat 988501 gggttcagca taatgcggct gtcttttttt cgcggctgtc tcagtttgcc tagtttgaga 988561 ctgtgtatgc tgatgctgtg gttgctgctg tccagcgtgc tggtgctgac ggccattttg 988621 ccgctggctt tgatgctgcg aacggtcctg gttatcaccg ctgcttccgc tgcttccgct 988681 aaatgcttgt ttgaccatgt ttcctacatt agaagcatca aacgtgttat tttctgaatt 988741 tcgtctgttc atttgtcctg tgataaaccc gctgattctt tggcggatct gaggtgataa 988801 tgcagtaata agcatagttg atcctatgat caatgctgcg gggctgattc ctcttcgctg 988861 gttgaacaac atgatccctc ctttgcagtg tattcatatt ttccccctcg ttagacaaat 988921 taaccgttat atttcccggg aaagcatttc ctccagattt gcatgcataa ttaaagccag 988981 ttagaaaaac ctataagtaa agtgataaag gaggaattca catgtttgga aaaaaacaag 989041 tccttgcgtc tgtgcttctt atccctttgc ttatgactgg ctgcggtgta gccgaccaag 989101 gtgagggcag acgtgataat aatgatgtaa gaaacgtaaa ttatcgaaat ccggccaatg 989161 acgatatgcg gaatgtaaac aatcgggata acgttgacaa caatgttaat gataatgtca 989221 ataacaatcg tgtaaatgac gataataaca acgaccgaaa acttgaggtt gctgatgaag 989281 cagctgataa agtaacagac ctaaaagaag taaagcatgc cgatatcatt gtggctggaa 989341 atcaagccta cgttgcagtc gttttaacca atggaaataa aggtgcagta gaaaacaatc 989401 tgaagaaaaa aatagccaaa aaggtaagat ctactgacaa aaacattgat aatgtttacg 989461 tttcagctaa ccctgatttt gtagagcgta tgcaaggata tggaaagcgt attcaaaatg 989521 gtgacccaat cgccggatta tttgatgaat ttacacaaac tgtacagcgt gtattcccta 989581 acgctgaata aatgaaagaa gccgcacaat ttgtgcggct ttttctttgc gttaatgaca 989641 cactgcgaac tcaggctgca tagagtaaaa ataaaaaggt acaagacgga ccggctcagg 989701 gagggagacg tttgcgggat ggcataggaa agcgtgcggc atccgctcta ttcctgtgcg 989761 gagtccttgt gatgctggct gtaagctcag ccatcgtatc aagcgcgatg tatatcctgt 989821 cttttccagg tcaggcatct ggaataacaa aagaacaagt gacgaagcac atgaagaaag 989881 agtcattcaa acaggccgat atttattaca cttctaagga aaagtcctta ctgccattga 989941 cgaaagaaac gcttgaatat gcggtcagta ttaatcagat tatgattgga tattcgaatc 990001 aaaagcctat tgacattatt ttttttccta atgaaaaaca gatggaggct tactccggtt 990061 tattggatgt agttggtttt tattctgaac gggagcagct gatcggattg ttgcctgaag 990121 agaaaaagaa actgttagaa ggggacgagg tagcggttta tttgtaccag agattgttga 990181 ttcatgaata ctcgcaccat gcgtttcacc agaaattgaa ggagcttgag acggatcccg 990241 atgagtttcc gttatggttt catgaagggt taagcgagtg gattgcgaac tatgaattgc 990301 tcatagatcc gatcacgttt tctgtcgtgc cctttgaccg tttgcagact gatcgagact 990361 ggcaggaagc tagagccgaa tatgacactg atgtctattt gcaaagcttt tatatgatcg 990421 atgagctgac ggacaaatac gggaaagaca ttatttcaga aatgattaag gaaacggcaa 990481 aaaaagggga ctttgaaaaa gggtttaaat cagcaacaaa ggaaagtctt gatcaatttg 990541 aaaaagattt taagaaaaaa tttgaaaaaa acagtgcggc attggatagt atctatccaa 990601 tgcctttgtt attagtgaag tccttgctga cccattccgc cttgtgtcgg aggcatttgt 990661 ccttgggcag gggcgaatga atttcgcagc tgttccatat cctgcgcatc aagctgagga 990721 acctggtaat agccgtgttt gttttggtat aggaaaattt caaatgccat ttcaacatac 990781 tcctgaattt gcgcagacag tacgcgtctt acggccggat ttgtcatttc cagagaagcc 990841 atcgtcagca tagaagcttg tgctttaatc gcgcaaagca tttgtcggct gatgatgctg 990901 tcatcaatat cattcatgga ttgaacaggt tttttaggct gtgacggctg catgccgtaa 990961 acagtctggt tgtcttcctt catcatataa gttgctgttt tttgtgaagg ttcgcttcct 991021 gttttgaagc attctgcagt tatattgtat tgagatgtga tgaattgatg ttgacgatca 991081 aggatgttta gtaattcttg atccttacag aattgtctca gcatcataaa ctgatcaagc 991141 acagtaagtg ttccggaaag cacctcatgc atatcaaaca tttcatgtcc gccgtggttt 991201 ttatgcggtt tgccaggaat acctttgttc atttgggatt gctgctgctg attgaactga 991261 tccaaaccga attcctcctt ttttttcaga tcagctgtat tttgtgtcag tctgccgtgt 991321 attatgcaga agcctgaaag gaattatatg ctgtctgtcg aaatgataag cagacaaaat 991381 cgttgtcatt atgtgtataa gggaggaaat atgatgaggc gtattctgca tattgtgttg 991441 atcacggcat taatgttctt aaatgtaatg tacacgttcg aagctgtaaa ggcagctgaa 991501 ccgcaacagc ctatatcgat tgagaaggca atacagcaaa aagaaggaca ggcacttgtc 991561 gaaggatatg cagtcggcca ggctgtttcc ccgcagcatt ataaactgac aagccctttt 991621 tcaaatgatt ataatgttgc gctggcagac cgtaaaaaca aaacatcgcc cgaacacatc 991681 cttcctgtgc aaatcccctc cgccttcaga agccaatttg ggctgcaaac caatccgctt 991741 cttcttggga aaaagataac ggttcaagga aagcttgaaa attactttaa cacgacagga 991801 cttaaaaacg ttcagtcgat gaacgtaacc gatgacacaa aaactccgcc ggctgaacag 991861 caagtgacca taaatgaagc acggggaagg ctgaatgaag aagtaacgat aaaagggatc 991921 attacagctg atcaaaacgc aatcggaggc gggaagctgt cgaccttttt gcaagatgaa 991981 accggaggca ttaacattta ttcgccatcc cctgaacaat ttcccgaatt aaaagagggt 992041 atggatgtca cggtgacagg gaaaatcacg tcttaccagg ggctgaaaga aatcgttcca 992101 aactcatcag gcatcaaaat caaccagtca aatcaatccc tccccgcccc caaacactta 992161 acaatcaatg aacttattaa cggcagccta ggtgatcagt atgaaggacg ccttgtgaaa 992221 ctaaccgctt ttgtttcctc aattccaagt tctcctgccg gcggcggtta caatgtaaca 992281 atgattgatg acgaccatca tgcaatgacg ctccgggtta tgaatgaaac aggggtgata 992341 aacgagcttg atgagggcaa atggtatgaa tttaccggtg tgttaagcag ataccaaacc 992401 tttcagctgc ttccgcgaaa atcggctgac ctgaagctgc ttgaagagca gcccgcacct 992461 ccgtctgcag agggagaata tgaagggatt gttgaccggg tagttgacgg cgataccatt 992521 catcttaaat ctccggtgct tggaacgaca aaaatccggt ttgtaaatgt agatgcaccc 992581 gaaacatatc acacaccaaa aaatgacgca gatgaaaatc aattaagatt tggcaaaaaa 992641 gcatctgact atctaaaaac ggttctgtcc ccgggtgata aaattactgt caaggtcggg 992701 agtgaagcca aggacagcta tggcagattg ctcggacaag tcataaccga atcaggttca 992761 aacgtgaact tagagcttgt aaaaaacggc tatgctccga cgtattttat ttggccggtt 992821 gacaatgaag aggattatca gcaatttcag gccgcagtag ccgctgcaaa aaaagatcaa 992881 aaaggaattt ggaatgaaaa cgatcccctc atggaaatgc cgtttgaatt cagagccaga 992941 gagcaaggga aaggcctgac aagatatgtg ggggactcgt cgaataaaac atatgtgcag 993001 ccagctgact ggaagaagat agctgtggaa aacagaattt tcttcgcctc agcaagtgaa 993061 gcggagagcg cgggatataa aaaaaggcaa acggcacctc aagaacatgt gccgcttaga 993121 attctcagca tgaatgattt gcatggcaaa atcgatcagc aatatgagct tgatcttgat 993181 ggaaatggaa ctgtagacgg cacgtttgga cgcatggatt atgccgccgc atatttaaaa 993241 gaaaaaaagg ctgaaaagaa aaactcgctg attgtgcacg cgggagatat gatcggcgga 993301 agctctccag tttcctctct tcttcaggat gaaccgactg tagaactgat ggaggacatc 993361 ggatttgatg tcggaaccgt gggaaaccac gaatttgatg aaggcacgga tgaacttctg 993421 aggatcttaa atggcggtga tcatccgaaa ggcacaagcg gatatgatgg acagaacttt 993481 ccccttgtat gtgccaattg taaaatgaaa tcaactggag agcccttttt gccggcttac 993541 gacatcatta atgtggaggg cgtacccgtt gcttttatcg gagttgtcac acagtcggca 993601 gctggcatgg ttatgcctga aggaataaaa aatatcgagt ttacagatga agcaacagcg 993661 gtgaataagg cggccgaaga gctcaagaaa aaaggcgtga aggccatcgc ggttctcgca 993721 catatgtcag ctgaacaaaa cggcaacgcc attaccggtg agtctgctga tcttgcaaac 993781 aaaacagatt ctgaaattga cgtgattttt gccgcgcata atcatcaggt tgttaacggt 993841 gaagtgaatg gaaaactgat tgttcaagcg tttgaatatg gaaaagcgat aggtgtcgtt 993901 gatgtagaga tcgataaaac gacaaaagac attgtcaaaa agtccgcgga aatcgtatat 993961 gttgatcaaa gtaaaatcga accggatgtc agcgcgtcag ccattttaaa gaaatacgaa 994021 acaattgcgg aaccgattat cagcgaggta gtcggcgaag ccgctgttga tatggaaggg 994081 gggtattcaa atgacggcga tacacctctt ggaaacctga ttgcggatgg tatgagagct 994141 gccatgaaaa cggattttgc ccttatgaat ggcggcggca tacgtgaagc gctgaagaag 994201 ggtccaatta cgtggggaga tctttacaat attcagccgt ttggaaatgt gttaacgaag 994261 cttgagatta aaggaaaaga tttaagagag attatcaatg cgcaaatctc gccggttttt 994321 gggcctgact acagcatcag cgggtttacg tatacgtggg ataaagaaac cggaaaagca 994381 gttgatatga aaatggcaga tggcaccgag atccagcccg atgccacata tacattgacc 994441 gtcaacaact ttatggcgac ggcgacagga gccaaatatc agccaatcgg actgctggga 994501 aaaaatccgg tgacagggcc tgaggatttg gaagcgacag ttgagtacgt gaagagtttt 994561 gatgagccaa ttgcgtatac aaaagaggga agaattaagc ttgctgaagc cagtgatatt 994621 gaagaccctg taacagaaga cccgataacg gaagagcctg gagatgatcc ggggacggag 994681 gatccgatta aagaggatcc aaggccaggt gaagatttgc ctgatataaa agaaactccg 994741 ggaacagcac cggttcatca gcttccgcct tcagccattt cgagattcaa tgaaatacca 994801 atcaacaaca caaaaaccgc tgatactgct aatagcatca gcacattgcc gttacaaacc 994861 gagactgcgg aaagcgggtc tgatcatcag cttccggata cgtcagcggg ctactataac 994921 tttatggtaa tcggtgcggc ggtgacattg tcaggaactt atctatatgt cagaagaaaa 994981 aggagcgcct ccagaacgtg aaaaaagtta ttccactatt catcattgct gccggcctag 995041 tgatcgcagg ctatggaggc tttaaattga tcgatacgaa tacgaaaacg gaacagacat 995101 taaaagaagc aaagctggcg gctaaaaagc cgcaggaagc ttcggggacg aaaaatagca 995161 cagatcaagc aaagaacaaa gcatcattta agcctgagac cggccaagcg agcggcattt 995221 tagaaatacc gaaaatcaat gcagagcttc cgatcgtgga gggcaccgat gctgatgatt 995281 tagaaaaagg tgtcgggcat tacaaggaca gctattatcc tgatgaaaac ggacaaattg 995341 tgctgtcagg gcatcgggat accgtgtttc gccggacggg agagctggaa aagggggatc 995401 agctccgtct tctcctgtca tatggagaat tcacatatga aattgtaaaa acaaaaattg 995461 tcgataagga tgacacatct attatcacgc tccagcatga aaaggaagag ctgattctga 995521 cgacctgcta tccgttttca tacgtcggaa atgccccgaa gcgctatatt atatatggaa 995581 aacgagtgac ttaaaaagcc gaggcagtgc ctgcggcttt tcttcatgaa aaatatgtgc 995641 ggcaaaggtt tttcatatca gcagggaaag gggcttcagc aactatgagc tcgtctgtta 995701 tcgggtgaac cgcttgtact ttattggcgt gcagtgcctg cctgtttagc agcttgctcc 995761 cgcctccgta aagcgagtct cctgtcaacg gatggccgag gctcgccaga tgaacacgga 995821 tttggtgtgt tctgcctgtt tccagctcta attcaacgag cgacagccgt tctttcgcat 995881 tgctggccat taccttgaaa tgagtgacgg ctgtttgccc gcctggtgaa acccggcgtc 995941 ttgtcgggtg tgagcggtct ctgccgatcg gtgaattaat tgtccctttt ttcgtccgta 996001 gcttaccttc agcgatagcg gtatacgtac gcttcagcgt ctttttctct aactgctggt 996061 ctaagatggc gtgtgccaaa cgatgcttgg caaaaacgat agcgccagat gtatcctgat 996121 caagacgatg gacgtggcgc accttacatg tttcgccatt tatctgataa tgatacgcga 996181 tcaaattagc cagtgtgccg gtttgcccat cctcattcgg atgcgtcgcg atgccagcgg 996241 gtttattgat gatgagcata tgattgtcct caaataaaat atcaagctcg ccatactccg 996301 gaatgaccga agatgcttca ctttcctgaa gatcaatgaa cacgcggtct ccctttttta 996361 caatcatatt gtttaagacg gattcgtgat tgacctttat ctgttgatgg gacatccagt 996421 cttgtatcac tggtttagaa gctttgagcg ctgttttgag tacggaaaac agccattggc 996481 cgtcctgttt ttcattgatg aggatctcaa gccctctgcc tttttggttc atgttaaatg 996541 gctccttttc gaagcggaag gctgctgttt ctcataggaa acacttacct tagctttcgc 996601 gtttttttct gtgctattct tgagtaagac ttaggatatt cgatggcaag aaaggtgatt 996661 gacgtgagaa ttgtgaacgc agcaactgca gaacaggaga gctttatcaa ggagctgtct 996721 atggagctga tccatgatgt atttcctctt tatttctccg aactggacat tcagcgcttt 996781 aaaaagaaag gcgttctgtc tttaaataac cattattacc aaggaacatt aaaagaagca 996841 tttcaaatta tggcttgtct gcaaatgata catattatcc tgaccaagcc ttcgccgcac 996901 tctgatttga gtgatcaggc gatttttgaa aaaaacagca agatgctgaa tgattttggg 996961 atttattttc cgtttgcttt ttctgacttt caaaagaaga ctaacaaagc ctttttcggt 997021 caaagaaggc tgatataatc atgcggcaag ggcttttcta tttttagaaa agctcttttt 997081 gtatcagaga aatcatatca taaaaccttt cctctaactc cctttttaaa cggctcgtgt 997141 ctgaacatac taatgattga aaggggtgct gacaatgagt tcagttaaag atacaatgac 997201 aacgcaggtg gcaaccgttt ctccgaatca aacgattcag gaagcggctt ctctaatgaa 997261 acagcataac gtcggggcga tccccgttgt agagcaaggt gttttaaaag gaatgctgac 997321 tgaccgtgac attgcattaa gaactacagc tcagggccgt gatggccaga cacccgtttc 997381 agaagtgatg tcaacagaac tcgtatcagg aaaccctaat atgagtctgg aagacgcgtc 997441 gcagctgatg gcccagcacc aaatccgccg ccttcctatt gtagatcaaa acaatctagt 997501 cgggatcgtt gcgcttggag acctggcagt caatcagatg tcgaacgagt ctgcgggatc 997561 agcgctgaca aacatttctc accaaaacat tcattaataa gaaagagctt gcagtgtgca 997621 ggctctttct tcacataaaa ccttactttt tgaaagcaga cttgtttcgg ggtatagtga 997681 gtgtatacat atgtctcaat tcgtactaaa ggagttgtac ccagtgatta aagcgttaat 997741 ttttgatttt gacgggctta ttctagatac agaaacacac gaatatgagg ttcttcagga 997801 aatatttgaa gagcacggct cagtgctgcc gctatctgtc tggggaaagg tcatcggaac 997861 tgctgcgggt ttccggcctt ttgaatattt agaagagcag atcgggaaaa agctgaacca 997921 tgaagagctc acacaattga gaagagagcg gtttgccaaa cgcatggaat cagaaaaagc 997981 gagacctggt gtcgaagcgt atttgaatgc ggcaaaggat ttaggcttaa aaataggcct 998041 tgcctccagc tctgattata aatgggtgtc cggccatttg aagcaaatcg gcctgtttga 998101 tgattttgaa gttattcaaa cggcggatga tgtggaagag gtgaagccga atcctgaact 998161 ctatttattg gcggcaaaga acctgggggt atcgccagcg gaatgtctcg cgtttgagga 998221 ttctgtcaat ggttcgattg ctgcgaaacg tgcaggcatg aagtgtgtca ttgtcccgaa 998281 taaagtaacg ggtaccttga tgtttgaaga ctatgatcac aggcttgaat caatggcgga 998341 gatggagctc gccctattgc ttgatcatct gaactcacaa aactagaaag gagcgagtag 998401 gttgtctgag aaattagatt tgacccggtt tgaaaagaaa atggttatcc gcaatatcga 998461 agagaaagac atcgacaaga ttatcgatct tcaaaaggac tgctttccag gaatggagcc 998521 ttggaagcgg gagcatttaa tcagccattt ggagcatttt ccggaaggac agttttgtgc 998581 agaattcgaa ggtgaaatta tcggttcgtg ctcaagtctc ctgattaact ttgatgaata 998641 tgatgaccgc catacgtggc aggacattac agatgacggt tatatcacca accataatcc 998701 tgacggcttg aatatgtacg gaattgaagt catggtgcac ccgaaataca gacgaatgaa 998761 gatcggccac cgtttgtacg aggcgagaaa ggacttagcc agacgcttaa acctgaaaag 998821 catcatcata ggcggacgga ttccaaacta tcacaaatat gcagaggaaa tgacagcgag 998881 agagtatgtt gaacaggtga cacgccacca aatttacgat ccggttcttt cttttcagct 998941 gatgaacggc tttaccctta tgcgaattaa cccgaactat ctcccggatg atacagcttc 999001 gatcaagtat gcgacgctga tggaatggaa taatgtcgat tatctaccgc agcagacaaa 999061 acgctattat aaatcggcgt tccctgttag aatttgtgtg atccaatacg aaatgaagaa 999121 aatttattcc tttgaggaat ttgcgaatca agtagaatac tatgtcgatg ttgcttccga 999181 cgcaagatct gattttgcgg tgttcccgga aattttcaca acccagctga tgtccttcct 999241 tgaggaacgg tcaccgagct tggcggtgca gagaattacc gagtatacag aagattacat 999301 cagcctgttt actgacttgg ctgtgaagta taacgtcaac attatcggcg gatctcattt 999361 cgtcgaagag gaaggcaaga tctataatat cgcttacctg ttcagacggg acggaacgat 999421 cgagaagcaa tacaaactcc atattacgcc gaatgaacgc aaatggtggg ggatcagcgc 999481 aggagaccaa gttcgcgtgt ttgatacgga ctgcgggaaa atcgcgatcc agatctgtta 999541 tgacattgaa tttcctgagc ttgcccggat tgcggctgat aaaggagcca aaatcatctt 999601 tacgccattt tgtacagaag accgtcaagg ctatctgcgt gtcagatact gttcgcaggc 999661 tagagcggtt gaaaatcaaa tttatacggt tatctctgga acggtcggaa accttccgca 999721 aacggaaaac atggatatcc aatacgccca gtcaggcatc tttgccccgt ctgattttga 999781 attcgcccga gacggcattg tcggcgaaac aaacccgaat attgaaatgg tcgtcatcgg 999841 cgatgttgac ctggaaattc tcagaagaca gcgccaaaac ggtacagtgc gccagctaaa 999901 agacagacga cgtgatattt atcatattca atataaaaaa taattcccaa aaaacccgcc 999961 tgaattggcg ggttttttta aacaaaagcg gaattgttta ggtgctttct ttaaaataaa 1000021 agtaaattgt atagtggatg tgccttatgg agtttctgta ttttcgccat ttcctatatc 1000081 atacagaaaa cggctaggct tcacattgct attgcaatgg ctgtccaagt tgtttcgagt 1000141 gcgaccttta tcagtacgat gctgagcatt gtcactttgc ctgttttgct ttggaagctg 1000201 catcctcttt cttcttgaga aaggggatgt tttattattt acgcggttta ttgactctga 1000261 cccggtctgg ctttatattg aaggcaggga aatcatcacc aagacatcac ataaagagaa 1000321 ggtctgtttc aattgaattg gcattatagg gaacgctaat gaaatggaga tgatggggat 1000381 ggaaaacatt cagcaaaatc agggattaaa gcaaaaagat gagcaatttg tgtggcatgc 1000441 catgaaggga gcgcatcaag cggacagcct gatagcccag aaggccgaag gggcctgggt 1000501 aaccgacaca gacggacgcc gctatttgga tgcgatgtcc ggtttgtggt gcgtcaacat 1000561 tggttacggc agaaaggagc ttgcggaggc tgcctatgag caactaaagg agctgcctta 1000621 ctacccgtta acgcaaagtc acgcacccgc aattcaactg gcggaaaagc tgaatgaatg 1000681 gcttggcggc gattatgtta tttttttttc caacagcgga tcggaagcaa acgaaactgc 1000741 ttttaaaatt gcccgccagt accatctgca aaacggcgac cacagccgtt ataaattcat 1000801 ctcaagatat cgggcatacc acggcaatac attgggagcg ctctcagcta ccggacaggc 1000861 gcagcggaaa tataaatacg agcctttgag ccaagggttc ctgcatgcag ctccgccaga 1000921 tatataccgg aatcctgatg atgcagacac gcttgaaagc gcaaatgaaa tcgaccgcat 1000981 catgacatgg gaattaagcg aaacgattgc cggggtcatt atggagccca tcattacagg 1001041 cggaggcatc ctaatgccgc cggacggata tatgaagaag gtggaggaca tttgccggcg 1001101 ccacggagcc cttttgattt gcgatgaagt gatctgcggg tttggacgga caggtgagcc 1001161 gttcgggttt atgcactacg gtgtgaagcc tgatatcatt acgatggcaa agggaatcac 1001221 aagcgcgtat ctgccattgt cagcgactgc tgtgaaacgg gacattttcg aagcgtatca 1001281 gggggaagct ccttatgacc gtttccgcca cgtgaacacg ttcggcggaa gcccggctgc 1001341 ctgtgctttg gcgttgaaaa acctgcaaat tatggaggac gaacagctga ttcagcgatc 1001401 ccgtgatctt ggagcaaagc ttttaggtga gcttcaagct ctgagagaac acccggcagt 1001461 cggggatgtt agaggaaaag ggctgctgat cggaatcgaa ctcgtcaaag acaaattgac 1001521 taaagagccg gctgatgccg ccaaagtaaa ccaagtggtt gcggcgtgca aagaaaaagg 1001581 gctgatcatc ggcaaaaacg gcgatacagt cgccggctac aacaatgtca tccagcttgc 1001641 gccgccattt tgcctgacag aagaggacct ttcctttatc gtgaaaacgg tgaaagaaag 1001701 ctttcaaacg atataatata aaagtgaatt attaaaggag cacatgatga gttttcacaa 1001761 ccagccgatc ttaccggcta ttcgcaatat gaagcaattt gatgagtttt tgaacagttc 1001821 attctcttac ggtgttattc ttgatattca tctcggccag ctgaagggcg tgatcaaaga 1001881 agcgcaaaag cacggaaaga acatgatggt gcacgtcgat ctcattcaag ggattaagca 1001941 tgacgaatac ggtgcggaat ttatatgtca ggatatcaag cccgctggga ttatttccac 1002001 aagatcgaat gtgattgcca aagcgaagca gaagaaaatt tatgccattc agcgcctgtt 1002061 tttgcttgat acaagcgcga tggagaaaag catggagttt atcggcaagc ataagcctga 1002121 cttcatcgaa gtgcttcccg gcatcgttcc gtcactcatt caggaaataa aagagaaaac 1002181 agggattccc atctttgccg ggggtttcat ccgtacggaa gaggatgtag agcaggcatt 1002241 gaaagcgggg gctgtagctg tcacaacatc taataccaaa ttgtggaaaa aatatgaaaa 1002301 ctttttgacg gaaagtgatt gacaccgctt tcatgcactg atacaattgc actaggttaa 1002361 tacattgtga tggagaactc ggagaccaca gcagctcttt acggcaaatg tttatgcacc 1002421 cgtaaagcgg tttgttgtgg tttttttatt ctcttcttct ctatcatgct ttttaatcgt 1002481 gactttagga ggaatgtgct atgacagcat tttggggaga agtcatcggt acgatgctgc 1002541 ttatcatttt tggtgcaggt gtttgtgcag gtgtcaattt aaagaaatcg ctttcattcc 1002601 agtctggctg gattgttgtt gtatttggat ggggattggg tgttgccatg gcggcatacg 1002661 cggttggcgg catcagcggt gcccatttga atccggcgct aacgatagcg cttgcatttg 1002721 taggagattt tccttggaaa gaggttccgg tttatattgc ggcgcaaatg atcggagcga 1002781 tcatcggtgc ggtgattatt tatctgcatt acctcccgca ctggaagtca acggatgatc 1002841 ccgctgccaa gctgggtgtt ttctcaacag ggcccagcat tccgcataca tttgcaaacg 1002901 ttttaagcga agtgattggg acatttgtcc ttgtacttgg aatcttggcc ataggtgcaa 1002961 atcaatttac agaaggactt aatcctttaa tcgtcggttt cctcattgta gcaatcggta 1003021 tttctctggg aggcaccacc ggctatgcta tcaatcctgc acgtgactta ggtccgcgga 1003081 tcgcccacgc ttttcttccg attccgggga agggctcatc aaactggaaa tacgcatggg 1003141 ttccggtagt cggcccgatt ttaggcggat cattcggcgg tgtattttac aacgctgcat 1003201 ttaaagggca catcacaagc agcttctgga ttgtaagcgt tatattggtt gtggtattgt 1003261 taggactcta tgtttatacg aaatcacatt ctgctaaaac attatcaaat tctaaatata 1003321 tttaatcaaa ggggagacat cttatggaaa cgtacatttt atccttagat caggggacga 1003381 caagttcaag agcgattctg tttaataaag aaggcaaaat tgtccactct gctcaaaagg 1003441 aatttacaca atacttcccg catcctggct gggttgagca taatgccaat gaaatttggg 1003501 gctctgtcct cgcggttatc gcctcagtca tctctgaatc aggaatcagc gcttctcaaa 1003561 ttgccggcat cggcatcacg aaccagcgcg agacgacggt tgtgtgggat aaagatacag 1003621 gaagtcctgt ctataatgca atcgtttggc agtccagaca gacgtccggc atttgtgagg 1003681 aacttcgtga aaaaggatat aatgataaat tcagagaaaa aacagggctt ttaatcgatc 1003741 cttacttctc cggcacgaag gtgaagtgga ttttagacaa tgtggaaggc gcaagagaaa 1003801 aagcggaaaa aggcgagctg ctgtttggaa cgattgatac gtggctcatt tggaaaatgt 1003861 caggcggaaa agcgcatgtg accgattact ccaatgcctc aagaacactg atgtttaata 1003921 tttacgattt aaaatgggac gatgaactgc tcgacattct aggcgtaccg aaatccatgc 1003981 tccctgaagt gaagccgtcc tctcatgtgt atgcggagac tgttgattat cacttcttcg 1004041 gaaaaaatat cccgattgct ggagcggcag gcgaccagca gtccgcattg ttcggccagg 1004101 catgctttga agaaggcatg gggaaaaaca cttacggcac aggatgtttc atgctgatga 1004161 ataccgggga aaaagcaatt aagtccgaac atgggctttt gacaacaatc gcttggggca 1004221 ttgacggaaa agtgaactat gcgttagaag ggagcatttt tgtcgcaggc tctgccatcc 1004281 agtggcttag agacggtttg agaatgttcc aggattcatc gctaagcgaa tcttatgcag 1004341 aaaaagtgga ttcaactgac ggcgtgtatg ttgttccagc atttgtcgga ctgggaacgc 1004401 cttactggga cagcgatgtg cgcggttcgg ttttcggcct gacaagaggg acaacaaaag 1004461 agcactttat ccgtgcgaca ctggagtcat tggcttatca gaccaaagat gtgcttgacg 1004521 caatggaagc agattcaaac atttcattaa agacgctccg tgtagacgga ggagctgtaa 1004581 aaaacaattt cctaatgcag ttccaaggag acctgttgaa tgttcctgtg gagcgcccgg 1004641 aaattaatga aacgactgca cttggcgcgg cttatttggc gggtatcgct gtgggattct 1004701 ggaaggaccg ttctgaaatc gcgaaccagt ggaatctgga taaacggttt gagcctgaat 1004761 tggaagaaga aaaacgaaat gagctgtata aaggctggca aaaagccgtg aaagcagcta 1004821 tggcttttaa ataaagtaat actatggtat aatggttaca agttaataag aacggtcctg 1004881 agatgaggag agaccacagc accaaagtgt aagcatgcac tttggctgtt gtggtctctt 1004941 tttctattta ccgtgacaac aaggaggaaa cgtaatgatg aatcatcaat tttcaagtct 1005001 tgaaagagat cgcatgctga cagacatgac gaaaaaaaca tatgacctat ttattatcgg 1005061 aggaggaatt acaggagccg gaacagctct tgacgcggca tcaaggggaa tgaaggtcgc 1005121 actaagcgaa atgcaggact ttgcggcggg aacatcaagc cgatcaacga agctggtaca 1005181 tggcggcttg cgctatttaa aacaatttga agtgaaaatg gtcgctgagg taggaaaaga 1005241 gcgggcgatt gtgtatgaaa acggcccgca tgtcactaca ccggaatgga tgctgcttcc 1005301 gtttcataaa ggcggcacat tcggttcatt tacaacatct attgggttaa gggtttatga 1005361 cttccttgca ggtgtgaaaa agtcagaacg aagaagcatg ctttcagcaa aagaaacgct 1005421 gcaaaaagag cctttggtga aaaaagacgg cttaaaaggc ggcgggtact atgtggaata 1005481 ccgcactgac gatgcgagac tgaccatcga agtcatgaag gaagcggtta aattcggggc 1005541 agagcctgtg aattactcca aagtgaagga gcttctttac gaaaaaggca aagccgtcgg 1005601 cgtattaatt gaagatgtgc tgacaaagaa agaatataaa gtgtatgcga aaaaaattgt 1005661 caatgctaca ggcccttggg tcgatcagct cagagaaaaa gaccattcga aaaacggaaa 1005721 gcatttgcag catacaaaag gcattcacct tgtatttgac cagtctgtct ttccgctgaa 1005781 acaggctgta tatttcgata cacctgatgg ccggatggta tttgcgattc ctcgtgaagg 1005841 caaaacatac gtgggaacaa cagacactgt ttacaaagag gcgctggagc atccgcggat 1005901 gacaacggag gatcgtgatt atgtcatcaa atcaatcaat tacatgttcc cggaactgaa 1005961 tatcactgcg aatgacatcg aatccagctg ggcggggctg cgtccgctga ttcatgaaga 1006021 aggcaaagat ccttctgaaa tttcacggaa agacgagatt tggacatctg actcaggcct 1006081 gatcaccatt gccggcggaa aactgactgg atacagaaaa atggcggagc acatcgttga 1006141 tcttgtccgt gatcgcttaa aagaagaggg cgaaaaggat tttggaccat gtaaaacgaa 1006201 aaacatgcca atctctggcg ggcacgtcgg cggttcgaaa aatcttatgt ccttcgttac 1006261 cgcgaaaaca aaagaaggaa ttgcagccgg tttatcagaa aaagacgcaa aacagcttgc 1006321 gatcagatac ggctctaacg tagatcgcgt ctttgaccgg gtagaagcgc tgaaagatga 1006381 ggccgcgaaa cgcaacattc cggttcatat tcttgctgag gcagaataca gtatagaaga 1006441 agagatgact gcaacccctg ctgacttctt tgtccgcaga acgggacgtt tattttttga 1006501 tatcaattgg gtaagaacat ataaagatgc cgttattgat tttatgagcg agcgattcca 1006561 atgggatgag caggcgaaaa acaaacatac agaaaacctc aacaagcttt tacacgatgc 1006621 ggtcgtaccg cttgagcaat aaatcataac gggctgtctg cagcccgtta tttcttttta 1006681 cgtgccgaaa gggggagatc tcaggttatc aagtgacaga ggcacccgct tcatataaaa 1006741 taatggcata agctgataca taggaggacg aatatgactt ggagaaagag ctatgaacgc 1006801 tggaaacaga cagaacattt agatctggaa ttaaaagagc gccttattga attagaggga 1006861 gatgaacagg cccttgagga ctgtttctat aaagaccttg aattcggtac cggcggaatg 1006921 cgcggggaaa tcggcgccgg gacaaatcgg atgaatattt acactgtgcg caaagcatcg 1006981 gccgggtttg cggcatacat ctcgaagcaa ggtgaggaag cgaaaaaacg gggcgttgtc 1007041 attgcttatg attcccgcca taagtctccg gagttcgcga tggaagcggc aaaaacactt 1007101 gcgacacaag gcatccaaac atacgtgttt gatgagcttc gcccgacgcc agagctgtca 1007161 ttcgctgtta gacagctgaa cgcttatggt ggaattgtgg taacggcaag ccataacccg 1007221 cctgaatata acggctacaa agtatacggg gatgatggcg gccagctgcc tccaaaggaa 1007281 gcggacatcg tcattgagca ggtaaacgcg attgaaaatg agctgacgat cacagtggac 1007341 gaagaaaata agttaaaaga aaaaggctta atcaaaatca tcggtgaaga tattgataaa 1007401 gtttatacag aaaaactgac gtccatttct gtacatcctg aattatcgga agaagtagat 1007461 gtaaaggttg ttttcacacc gctgcatgga actgcaaata aaccggtcag acgcggtctt 1007521 gaagcactcg gctacaaaaa tgtaacggtt gtcaaagaac aggaactgcc ggattcaaac 1007581 ttctccactg ttacatcgcc gaacccggaa gagcatgcgg cattcgaata tgccattaag 1007641 cttggggagg agcagaatgc agatattctc atcgcgacag atcctgatgc tgaccgcctc 1007701 ggcatcgcgg tgaaaaacga tcaaggcaaa tatacagtgc tgacaggaaa ccaaaccgga 1007761 gcgttgctgc ttcattacct gctttctgaa aagaaaaaac aaggcatcct gcctgataac 1007821 ggtgttgttc tcaaaacgat cgtcacaagc gaaatcggcc gtgctgtagc ttcttcattc 1007881 ggccttgata cgattgatac gctgacaggc tttaagttta tcggtgaaaa gattaaggaa 1007941 tacgaagcat caggccagta taccttccaa ttcggttatg aagagagcta cggttattta 1008001 atcggggatt ttgcccgcga taaggacgcc attcaggctg cgcttttggc agttgaagtt 1008061 tgcgcgttct ataaaaaaca gggaatgtca ttgtatgagg cgctcatcaa tctctttaac 1008121 gaatatggtt tttatcgtga agggctgaaa tccctgacgc tgaaaggcaa acaaggagca 1008181 gagcaaattg aagcgattct tgcttccttc agacaaaatc cgccgcagaa aatggcgggc 1008241 aaacaggttg tcacagcaga agattacgct gtaagcaaac ggacgcttct gactgaaagc 1008301 aaagaagaag ccatcgactt gccaaaatca aatgtattga aatacttcct ggaagacggg 1008361 tcttggttct gtctccgtcc ttctggaact gagccgaagg ttaaatttta tttcgccgta 1008421 aaagggtcat ctttggaaga cagtgaaaag cgacttgccg tcctttctga agatgtaatg 1008481 aagacggtgg atgaaattgt tgagtcaaca gcaaaataat tcaagtatga gctgggtcat 1008541 tgtaaatgat ccggcttttt ctttttctca tccaaaagtc tgaaagaaaa tcatcctaca 1008601 agtgaagcaa tgaaatacaa aaaactggta taatcttaaa tacaagatca atgccggagt 1008661 gagaaacgtg agcaaaacga ggatggaaaa attaaaaacg ctgaaaacga ttgcggaaac 1008721 cttaaatcaa gggcacgata tcaaagcaac actggatgag gttttaaaag agttgctgag 1008781 tctgacaaac cttcaatccg gatggatttt tctgatcgaa gaagatgggt cttatacgtt 1008841 agcggccgac gcttatctgc ccccggcttt aagccgcaag gaaaaagtgc tgatgtgcga 1008901 aggggagtgt tactgcctga cgaaattcaa taacggaggg cttagaaaag ctgcaaatat 1008961 catgaactgc aaacgcatcg aatcagcaga aaacctgcat tgttttgaca cagaagggat 1009021 tacgcatcat gcaactgtgc ctttagaaga cggggacaga agattcggat tgttaaatgt 1009081 agcggcggcc ggaaaaacca tgtttgatga ggaagagctg catttactcg agtctgtcgc 1009141 ctttcagatc ggaacggcaa tccagcgtat gaggctttct gaatatcaac aaaaaaatgc 1009201 tcttttaatg gagcgtaacc gcctcgctca ggagcttcac gattcagtca atcaaatgct 1009261 gttttccgtc agtttaactg ccaaagctgc gaagacacta acaaaagatg aaaatttaca 1009321 gcagatgatt gatttcatcc aaaacctatc acaggacgcg ctcgcagaaa tgaaagcgtt 1009381 aatttggcag cttcgccccg gaggattgga aaaagggctg gctgaagcca ttaaaagcta 1009441 tggtgcgctc attggattga agatcatttt tacacaaaaa ggctgtcctg ttctgactga 1009501 tgagcaggag catatgctat ggcgtgtcgt acaggaagct ttaaataact gcaaaaagca 1009561 tgccggaacg gatacggcgt atgttagtct gactgcttct ttgtgccatg cggagctgga 1009621 tatcatcgat catggggcag gatttcgcta tgaagcgcat gccggtctgc cttcacttgg 1009681 cataaaaggt atgaaagagc gagcggaaaa agccggagct aagttttgga ttgagtcagc 1009741 gcttggaact ggaacaaagc tgtccatcag gcttccgcta aaaagccgaa aaggaggggc 1009801 ggtatgaaaa ttgtcattgc tgatgatcat catgttgtca gaaagggtct gcgttttttc 1009861 tttgccaccc aggatgatat tgaagtcgtc ggagaagctg caactggatt agaagccctc 1009921 cgtgtcatcg aagagacaaa gccggatctt gtgctaatgg atttgtctat gcccgagatg 1009981 gacggcattc aagccattaa aaaagcaata cagcaatttc cggatacgaa tatcattgtg 1010041 ctgacgagct actctgatca ggagcacgtc atccccgcgc ttcaggcagg cgcgaaggcg 1010101 tatcaattaa aggatacgga gcccgaggaa ttggtgaaaa cacgacaagt gcatggtggc 1010161 gaatacaagc tttctacagc tattatgccc catgtgctga cacatatgaa aaatcagcac 1010221 gacccggaaa aagaaaaata ctatcaatta actagaaggg aaaaagacgt tctgactgaa 1010281 atagcgaacg ggaaaagcaa taaagaaatc gcagcagcct tgtttatttc agaaaaaaca 1010341 gtaaaaaccc atgtatcgaa tcttttagca aaacttgaag tggccgatcg cacgcaagca 1010401 gcgcttttcg cagtgaaata taacctgaat ggagagatct caaaatgaac atgttagtca 1010461 taaatggcac gccaagaaaa catggcagaa caagaattgc agcatcctat attgcagctc 1010521 tgtatcacac ggatttgatt gatctaagcg agtttgtatt gcccgttttt aacggtgaag 1010581 cggaacaatc tgaactgttg aaagtacagg agcttaagca acgcgttacg aaagcggatg 1010641 cgattgtatt attatcgcct gaatatcaca gcggcatgag cggcgcttta aaaaatgcct 1010701 tggattttct aagcagcgaa caattcaaat ataagcccgt tgcattattg gcagtagcgg 1010761 gaggcggaaa aggcggcatc aatgcgctga acaatatgag aactgtgatg cggggtgtct 1010821 acgccaatgt cattccgaag cagctggtgc ttgatccggt gcatattgat gttgaaaatg 1010881 ctacagtggc tgaaaacatt aaggaaagca taaaagagct tgtcgaagaa ctcagcatgt 1010941 tcgcaaaagc aggaaatccc ggcgtctaaa cgccgggatt tgtttatgtg agaagggcta 1011001 tttgatcttc ataagtcagc tctgtggcat gatcaatata tcggagaagg gaatacagca 1011061 tcttttctaa aacggcgtaa tcctgttcaa aatgatacgc atgcagaaaa tgctcaattc 1011121 gttttgataa caaatcgtcc tctgtacgca ccattaaaat taataaatta tcccattgag 1011181 aacgatgggt gtaataaagc gctttatcgt aatcggcata atccatgaat cgcttctcct 1011241 ttcttgggtg agaagttcat gattagttta tgccgcatcc tctgttattg acggggcaaa 1011301 acttgccgtc tgcgtcagta aaggggtagc aatatgaggg agacataaaa tcaaaatgcc 1011361 tgaatgaaga tatcgctttt ggtaaaccta tgagggaata tattctgggt acaggagact 1011421 gaaaaaatga aatccctgcc gtataccatc gcacttcttt tttgcggatt gattatcgtg 1011481 tcaatggctg caaaaggtca ttcaacggac acagacgagt ccgttcaaaa gtgggaacag 1011541 cttgcctgga gcaaaattca ggatgaatat aagggcgctt cattttctga ttatgcttat 1011601 atggggcgta cagaggtgaa tgatcagcag actaaagatg tctttcgggt gacagtcaga 1011661 cagaaagatg acactttttc tgttcgggcc gaagtctatt ttcatccggt gacaaatcat 1011721 atgatcagca tcaacgtctt taggctctaa taaaaaactg tacagccgtt aaggccgcac 1011781 agtttctgtt tttagaaata tcgttttgca ccgagatagc gctgtttcca gtaagagttg 1011841 ttcatattgg aaatgacaac tccggaatcg ttggcattta tgaattcccc gttgcctagg 1011901 taaattccga cgtgggaagg gccggcttta tatgttgaaa agaaaacgaa atctccgaca 1011961 gcaggctggc taactgattt cattgtgttc caatatcccg ctgccgttaa tctagatacg 1012021 gatgtgactt tgttcagtac atagtaaatg aatccgctgc agtcaaaccc ggacggtgtc 1012081 gtgcctcccc agcgatacgg aaccccaagc tgcgctttag cggccgaaat cattgtgtta 1012141 atcttcgcac tcgttgagct ggtggtgttt gaagaaccgg atgaagacga tgatgaagct 1012201 tttccggaaa tgaccagctt ttggccaacc tgcaagacat ccgtttttaa attgtttttc 1012261 tcacgaatct gctgagctgt tacattaaat ttttgagcaa tcacccataa ggaatcaccg 1012321 cttttcaccg tgtatgtagt cgtcgtgccg gagcttgcat ttgacgaaga agacgacgat 1012381 gatgaagagc ctgaagatgc tttacctgtc agcttcaata cttgtccaac gtaaagcaca 1012441 tctgatttca gattgttgat atttcggatt tgctgtacag tcaggttata gttgtttgcg 1012501 attttccaaa gtgaatcacc gcttttaacg gtatatttag ttgttgctga agtttggttc 1012561 gatttggatg aattgtcttt agaagacgta tcagagccgc ttgattttgt tttcaacacc 1012621 tgattcacgt aaatggtgtc tgattttaag ttgttcaaga ccttcaattc agcgatggac 1012681 atattgactt tgtttgcaat tttccaaagt gaatctccaa gctgcacctt atatgttccc 1012741 gtagaagatg aagaacttga actcttatta gaactgcttt ttgaactgga gcttgaactc 1012801 ttattagagt tgcttttttt actggaacta gagcttgaag aaacagtacc ggacaccttt 1012861 aatttctgcc cagcacgaat taaatcgctg cttagtccgt ttaatttttt cagttcctgc 1012921 accgtcattt taaactcatt tgcgatcagc caaagtgaat ctccgctttt cactgtgtaa 1012981 acagaacttc cgctcttctt ggttgttgag cttgaagtag atgaagaagt gctggatttg 1013041 ctgcctggaa tagtaagcgt ctggccgatc gacagaacag tagtcgaaag atgattggcg 1013101 gatgtgaggg ccgccacact tgtgttatag gtttgggcca gtttccataa agaatctccg 1013161 cttttgacct taatcgttgc tgcttcagct ggtgtcacta ctaaagttgt gccgacaatc 1013221 gcagatgctg tcagccctgc tgctaatttc tttttcatct tagctctcct ttttccccca 1013281 atgattttgc atttgctgtt tcttttttat atcggcacat ttgtctcatc gttttgcctt 1013341 tttataaaaa tagccaaatt atcttaacaa taagggggaa aaagggcata aaaaaagaag 1013401 gaatcttaat ctattccttc atttttaaaa gcttcatgat atcttctttg tttttgacga 1013461 ggtcgcgcag tgtgtatttg tctaaaactg cgaggtaggc taaaagcgct tcattcagca 1013521 catgttttaa gccgcaaacc ggggaaataa cacagagatt cttgttcgca tcaaaacatt 1013581 caacaatatt aaaatcgtcc tccgtttttc tgacaacctc accgatgttg atgtcttcag 1013641 ggtccatgcc taatcgtatg ccgccgcccc gtccgcgtat cgtttctacg tagccgagct 1013701 ggccgagcct gtatatgact ttcatgagat gattttttga aatagaatac gtttcggcaa 1013761 tctgttttat atttgaaagt tctccgggac gctctgcagc cagaaaaatc aacactctta 1013821 atgaataatc tgtataattg gttaacttca taataagacc tcagaataag acattttcta 1013881 tatcttatca taatcgattg aaaaatgaaa aaaaaggaat taaaaaacat gcacccagct 1013941 gggtgcatgt tttttgctta catgtcattc ggcggatttt ggtttttacg gtttttttcg 1014001 atttctgtgt tttgcatttt gcgttcaaat gtagacagat aacgtgatgc aaaatcctta 1014061 ccgccaaggc cgaaggataa accaaaagca agtgcgaagc cgctaagaac gatgatgaac 1014121 gcggaattga cgattgtcgc agcgacaccc agctgatcca gggccataaa gaaagcaagt 1014181 gcgataatcg tatatttagc aataggcgct aaagacttga attcctgacc ttttatcatg 1014241 cttgcgagca cttttctcac caattctcct gcgtaaaggc cgagtccgag aatgaatact 1014301 gcgacaagga cattcggcag atacgcgatg atgccggtgg caatttctac gaggaagtgc 1014361 agccgaacaa tttgaagcgc ctcagctgta aagagcagaa tgacaatgat ttgcgcaatc 1014421 ataccgacaa cttgagacaa ggacagcttt gcaggcgttc cggcttccat gcccattttc 1014481 cctaagacag aatcaaagcc tgcgcgatgg agcagtccgg acaccatgga tttcacccat 1014541 tttcctgccc agatacccgc taatacaagc acgatggcaa tcatgatgtt cggaagcatg 1014601 tttaaaatcg tattcagcat agagacagct ggttttgaaa tgccggcgac atccagctga 1014661 tcaagcgctg aaatgaccac cggaatcata atgagcacat aagcgattgt tccgatgact 1014721 gctgaaaggc ttgtgtcttt taagtaaatt gataaaccca tacgtgccgc gaatctttcg 1014781 gtgccgatgc ttgcaaggaa attcgtaatg atatcacgga caaggcgggc aacaagccat 1014841 ccgattaata cgataagcgc cgctgcaaat aatttcggca gaaaagcgag cacgctttcc 1014901 atcatatttg taaaaggacc tgaaatgccg ctgattttca aagaagataa gacccctggc 1014961 agaaaaacaa gcagcacgag ataaaagaca atttgtgaag cggtattgac agcctggtga 1015021 atatcttttc cttcagacac caaattccac ttgcgcagtt tgtcactcgt gttcagcttc 1015081 atcccgattt ttttgacaag gaagctcaaa acagaagctg cagcccatcc taacagcaga 1015141 atgagtccgg ctttcagcac gcttgggatc gcagctgcaa tcgccgaaag catactgaca 1015201 aacggcgatg ccactgttgt caggtgcaaa atgttaaaga ataaaataaa gacgatgatc 1015261 agtgcgataa aataaacgac cttgcttatg actttttccg aggaatagcg tgaaggcttt 1015321 ttcccagcaa agagcttgtc gtcgattttt gttttgctga gtcctttgta taccgctttt 1015381 tcaatgattt tagcaatagc ccagccgatt aataagacga gtaaagcaat gattacgttt 1015441 ggcagcttac tgagataaga agaaaacacg tctgctacat tcaattggta tcgctccttt 1015501 ttcgtagtat ggtgtgtgtt tacccactta tccaataagc aaacagatga atgtgccggg 1015561 ggaatttttt cttgcccgag tgagactatc atcttttgtc tggcgggctc atacattata 1015621 gataagtcca agtagggggg attcggttga acgcggagga gaagaaggga ttacagcggg 1015681 caattgagga aattaccgaa attgcaaaag gattcggcct tgatttctac ccgatgagat 1015741 atgaaatctg cccggctgaa attatttata catttggcgc gtacgggatg ccgacaagat 1015801 tcagccactg gagcttcggc aagcagtttc acaagatgaa gctgcactat gatctagggt 1015861 taagtaagat ctatgagctg gtcattaact cagatccatg ctacgctttt ttgctggaca 1015921 gcaactcact gatccaaaat aaattgattg tcgcacacgt tcttgctcat tgcgatttct 1015981 tcaaaaacaa ctgccgtttc caaaacacga agcgcgatat ggtggaaagc atggcggcaa 1016041 cagctgaacg gataaaacac tatgaacagg ttcacgggat aaaagaagtc gaatcttttt 1016101 tagatgcaat cctttcgatt caggagcata tcgatccgtc gttggtccga ccaaagctcc 1016161 aatggagtgt ggatgatgag gaagaggaga ttgaagaggc agccacgcct tacgatgatc 1016221 tatggtcttt agatgaaaag aaaccgaaaa aacaagtgaa aaaatcgaaa aaaccgttcc 1016281 cgccgcggcc tgaaaaagat atcctgcttt ttatcgagga gcattcccgg gagctggagc 1016341 catggcagcg tgatatatta acgatgatga gagaggaaat gctttatttc tggcctcagc 1016401 tggaaaccaa gattatgaat gagggctggg cttcctattg gcaccagaga attatacgtg 1016461 agcttgattt aacctctgat gaagcgatcg agttcgccaa gctgaatgca ggtgtcgttc 1016521 agccgtccaa aacaggcatt aatccttatt atttagggct gaaaatattt gaagacattg 1016581 aaaagaggta caacaacccg acggaggaaa tgaagaaaat gggcgtgcag cctgactccg 1016641 gccgggagaa aatgtttgag gtcagggaga ttgaatccga tatctctttc atccgcaatt 1016701 atttaaccaa agaattagtc atgcgcgagg atctttattt gtttcaaaaa cagggccgag 1016761 attataaaat catcgataaa cagtggaagt cggtgcgcga ccagctcgta agcatgcggg 1016821 taaatggcgg ttttccatat ttgacagtaa acgacggcga ttatatgaaa aataacgaac 1016881 tctatattaa gcattggtat gagggcatag agttggattt gaaatatttg gagaaagtgc 1016941 ttccttattt attccagctt tggggaagaa gcgtgcacat tgagtctgtg cttgaggata 1017001 aggaagtcat gttttcgtac gacggaaaag gtgttcaccg cagatattta taaaaaagag 1017061 gatgcagcgt tctgcatcct ttttattttc cagtttttaa aatcttaaat atgatgtttg 1017121 cctggtccgt attgttaatc aatccgcgga atttttcttt tccggggccg tacgcgtata 1017181 ccggtacttc ttcgccggta tgatcggtac tcgtccatcc gctgttggag cgggtattaa 1017241 aaatcttgat gatggctttg gaggcccctt tgcttttgtc agcctgtgca gctgcttcaa 1017301 cgcttttgat ttcttcagat gtgactttca gattggcata gcgggcgagc acatctttaa 1017361 ccggcttgcc ttcactgatt tttttggcca tgaattcagg tgttttctta gcggagagaa 1017421 tcggttctgc gtgccaattc ttttccccgt ttgcgccaat ggtaaagccg ccggttgtat 1017481 ggtcagcagt tgcaatcaca agtgtatgtt tgtctttttt cgcaaattca atcgcggctt 1017541 tataggcctg ttcaaaatct ttaacctcgc tcatggctcc tactgtatca ttgtcatggg 1017601 ccgcccagtc aatctggctc ccttcgacca tcaagaaaaa tcctttttta ttttggttca 1017661 ggcgatcaat tgctgaaacc gtcatgtctt tgagagacgg tgttttactg tcacggtcga 1017721 gcgctttagc aagccctcca tctgcgaaaa gcccgagcac ctgctgatct ttattttttt 1017781 tcaatgcttg tttagttgtc acatagctgt agccggcttg tttgaattcc tttgtcaagt 1017841 ttctgtcctt gcggttaaaa taagattttc cgccgccgag cagcacgtct attttatgtt 1017901 tgccttttat cttgtcatcc atatagctgt tggcgatttg gtccatgttt ttccgtgatt 1017961 cattgtgggc gccatatgcg gctggagtgg cgtggttaat ttcagacgtg gcgacaagcc 1018021 ctgttgactt gccttgctgt ttggcctctt caagtacaga tttcactttt tttccgtttt 1018081 tatcgacgcc aattgcattg ttatatgtct taacgcctgt cgctaatgct gttccggctg 1018141 ctgctgaatc tgtaatatta tagtcagggt catccggatg cgtcatcatc atgcctgtca 1018201 ggttccggtc aaattctgtt aacttcgggt tattcggtgt gtcaccgtta tttttcatgg 1018261 aacggtaggc tcttatgtaa ggcgtcccca tgccgtcgcc tatcatcaca atgacatttc 1018321 tgatctcagc tttgtcttgt tttttggcgc tggccttttc tgtttgctga agctcagctc 1018381 cggcaaagat tccagctgta aggacagaaa cagcggcgat tggcagaagt tttgatttca 1018441 tattttgaaa caaactcatt tttttcatgc ctcctttaat gtattccgtt tatcatgtta 1018501 gggaaacttt gttaaatgcg gctgttgatc atgtaaacaa taagtaaagc cttgtaagga 1018561 aatgaaaaaa cgcttttcgt tatcttgcct tatttgatgt aaagcattca tttttcagaa 1018621 aaatctttac ctctctgtct ttgcatgata tgtttgttta aataaaaaaa ctgcggataa 1018681 ccacagctct cctcgaatat actttatcac tcatttttcc gatatatgag ccgaccccga 1018741 aagtttttca tttatttcct ttatgttgaa aaacatccca taaaacatga caaaagcact 1018801 cgttttttgt cacctttgca atgaaaatga aatatttaat acccttaaaa actttttttt 1018861 agaacgaata attaagaaat ttgtcacatg aagtcaagac tatttctgat gggaatctat 1018921 ccttataata gaaatcaata agattaattt aaaaaaagag atacatatat atagagttaa 1018981 catttgggga ggaaaatatg aaaaagcaaa tcattacagc tacgacagca gttgttttag 1019041 gatcgacgtt atttgcagga gcggcatctg cacaaagcat taaggtgaaa aaaggcgaca 1019101 cgttatggga tctttcaaga aaatacgaca caacgatcag taaaattaaa tcagagaacc 1019161 accttcgttc agacattatt tatgtgggac aaactttatc gattaacggc aaatctacaa 1019221 gttcaaaaag cagcagttct tcttcctctt cttctacata caaagtaaag agcggggaca 1019281 gcctttggaa aatttcaaaa aaatacggca tgacaatcaa tgaactgaag aagctgaatg 1019341 gcttaaaatc agatttgctt cgtgttggac aagtcctgaa actgaaaggt tcaactagtt 1019401 caagcagctc cagctcatca aaagtgtcat cgtcttcaac ttctacttat aaagtgaaga 1019461 gcggagacag cctttctaaa attgcgagca aatacggcac tacggttagc aaattaaaaa 1019521 gcttaaacgg cttaaaatca gatgtaatct atgtcaacca agtattgaag gtgaaaggaa 1019581 caagcacaag cagctcaaaa cctgcttcat cttcatcgtc ttcaagcagc aaaacgtcat 1019641 ctacatcact taatgtgagc aagctggttt ctgatgcaaa agcgttagtc ggaacgccat 1019701 ataaatgggg cggaacgaca acttcaggct ttgactgcag cggattcatt tggtacgtac 1019761 tgaataaaca aacaagtgtg ggcagaacaa gcactgcagg atactggagt tctatgaaga 1019821 gcattgccag cccgtctgtt ggtgatttcg tcttcttcac aacatataaa tccggccctt 1019881 ctcacatggg gatttacatt ggaaacaaca gtttcattca tgcaggatct gacggcgtac 1019941 aaatcagcag cctgaacaac agctactgga agcctcgtta cctcggtgcg aaaagattct 1020001 aatttttaga gaaaacccgt tcattggaac gggttttttt cattagacgg agcacaggcg 1020061 ttttggttgc tcctaaaaat gaaaatgtga taaaaaatcc aagaactttt tttctttctt 1020121 attttcataa agggcaatcg cgtaagcgcc ggcatagggc agctgtacag actgataagg 1020181 aattctgatc atctgtttct ctgctaactc acgctttact gtagataaag gcagaaatga 1020241 aactccgagt ccttccttga taaaccgttt cgttatatgt gtttgagtga ccttcattgt 1020301 tctcacaaat ggaaatgtca ttctgacttg acggagcaag tcgtcccagt aatcaggatg 1020361 attgtgggtc aaaagcaggt attgttcgag cacctctttg gcatcaattt cgttgtcttc 1020421 tatgaaacgc ttatcgggcg gggcaacaag gacgacaggg tctttgtata agcagtggca 1020481 gcttaaagaa gaagactgta cctttaaaca gcttagtccg atatctgctt ccccggcttt 1020541 aatcagtgac gcgatttccg ctgattcgaa aatcgtaacc gccatttctg tttccgtatt 1020601 cattgctgtg taccgcttca tgacagaagg aagcactgta tctgcaataa gcggagaaac 1020661 cgcgagctgt aaggtttgag agtagccttg tctcactctg tgaagctctg ccatgctgtt 1020721 ttcataatca tcaagaagcc tgagcgcata cggcaaatac gccctgcctt catcagtcag 1020781 ctggatttgc ctgcctttac gctcgaacag cttgcagctg atttcttttt ctaattgctt 1020841 gatatgtacg gtcacagtag gctgagataa gaaaagcgtt tccgccgttt ttcggaagtt 1020901 ctcatatttt gcagcggtca caaaggtgtg aagccatttg aaatccattt ctattctccc 1020961 tctgattaat atttttaatt aattcccttt aaaatattga ttatttttta aatattatat 1021021 ttactataat aacagaaaag gataggggga atacaaatgg tacattacgg attaaaggga 1021081 attacatgtg tagaaacatc catcagccat attgatggtg aaaaagggcg tctgatttac 1021141 agaggacatc atgcaaaaga catcgcactg aatcacagct ttgaagaagc ggcttatttg 1021201 attttatttg gaaaactgcc ttcaactgaa gaattgcagg tatttaaaga taagctggct 1021261 gcggaacgga atcttccgga acatattgag cgcttgattc aatcactgcc aaacaacatg 1021321 gacgatatgt cggtgctgag aacggttgtt tcagcattgg gggaaaatac gtacacattc 1021381 catccgaaaa cagaggaagc aatccggctg attgcaatca cgccttctat cattgcatac 1021441 agaaaaagat ggacgcgcgg tgaacaagca attgcacctt cttcccagta cggacatgtc 1021501 gaaaactact attatatgct cacaggtgaa cagccttcag aggcaaaaaa gaaagcgctt 1021561 gaaacctata tgattctggc cacggagcac ggcatgaacg catcgacttt ttcggcacga 1021621 gtcacgttat ctacagagag tgatttagtg tcagccgtca cggctgctct cggtacgatg 1021681 aaaggtccgc tgcacggagg tgctccttct gcggtgacaa aaatgcttga agacattgga 1021741 gaaaaggaac atgctgaagc atatctgaaa gaaaaactcg aaaaaggaga gcgcttgatg 1021801 ggattcggcc acagggtgta caaaacaaaa gacccgcggg cagaagcttt gagacagaaa 1021861 gcagaagagg tggccggcaa tgaccgtgat cttgatcttg cgctgcatgt agaagcagaa 1021921 gcgattcgtt tgctagaaat ctacaaaccg ggacgaaagc tgtacacaaa tgttgaattt 1021981 tacgcagctg cagtgatgag ggccatcgat tttgacgatg aattgtttac tccgaccttt 1022041 tcagcaagcc gaatggtagg gtggtgcgcc catgtactgg aacaggcaga aaacaacatg 1022101 attttccgcc cgtcagcgca atataccggt gccattcccg aggaagttct ttcataacat 1022161 attttggcgt ttattcattt ctgtcgtgtg gtaacgttca gtatcaacca catgtctagg 1022221 agtgatgaat gtgaacccaa tggacagaca aacagaagga caagaaccgc agcatcagga 1022281 cagacagccg ggcattgagt caaaaatgaa tccgctgccg ctgtcagagg acgaggatta 1022341 tcgaggaagc ggaaaactga aaggaaaagt tgcgatcatt actggaggcg acagcggaat 1022401 agggagagca gcagctattg cctttgctaa agagggggct gatatctcca ttctatactt 1022461 agacgagcat tcggacgcag aggaaacacg caaacggatc gaaaaggaga atgtccgctg 1022521 cctgcttatc ccgggagatg ttggggacga gaaccattgt gaacaagctg tgcagcaaac 1022581 agtggaccat tttggtaaac tcgatatctt agtgaacaac gccgctgaac agcatcccca 1022641 ggacagcatt ctcaatattt caacagaaca gctggaaaaa acctttcgca caaatatttt 1022701 ttccatgttt catatgacga agaaagcttt gcctcacctg caagaggggt gtgccattat 1022761 taatacgaca tcgattaccg cttatgaagg ggatacggcg ttaattgatt attccagcac 1022821 aaagggtgcg attgtttcct ttacgcgttc catggcgaag tcgcttgcag ataaaggcat 1022881 cagagtgaat gcggtggcgc ccggtccgat ttggacaccg cttattccgg cgacattccc 1022941 tgaggaaaaa gtgaaacagc acggcttgga taccccaatg ggaagaccgg gacagccggt 1023001 tgagcatgca ggcgcctatg ttctgctggc gtctgacgaa tcttcctata tgacagggca 1023061 gaccattcat gtgaatggcg gccgttttat ttcaacgtaa tcaacgaaaa accagctcaa 1023121 gagctggttt tttgtgtggt gaaaaatttc aaaataaaaa atttgtcgat ttttctaaca 1023181 attttgtttt catttttgca attttatata taatattgag taggagaaag gaatgattcg 1023241 cgaccagtac aaatatagta gaaaaaaaag aataatgacc attgttactc atgaattcag 1023301 aaaattcaaa taaaatatat aaaaatagat gatcgggagt tgaaggggaa tgaaagggag 1023361 cgtttttagg aagaaaagca ttcaggattt aatcgctgcg acgagcgggg aaaagtcttt 1023421 aaaaagagaa ttaggggcat ttgatttaac gttgcttgga atcggcgcca ttattggcac 1023481 agggattttt gttctgacgg gaacaggcgc agtcacggcc ggtcccgggc tgacgatttc 1023541 atttgttgtg gcggcgttgg cttgtttatt cgccgccctg tcttacgcgg aatttgcgtc 1023601 aagtgtgcct gtttcaggtt cggtgtatac attcacttat gcgacattgg gagagcttat 1023661 ggcctttatt atcgggtggg atttaatttt agaatacatg ctggcggtaa gtgcagtgtc 1023721 ggtcggctgg tctggttatt tccaatcgtt tttatcaggg cttggcattc atcttccggt 1023781 tgctttaaca gcggcaccgg gcgcagtgaa aggcaccttt accctgttta atcttcctgc 1023841 attcgtcatt gtaatggcga tcacatattt gctttattta ggcatcaaag aatcaaaaag 1023901 agtcaacaat atcatggtta tcttgaagat actggttgtt ctgctgttta tcgcggtggc 1023961 agccgtttac gtgaagccgc acaactggca gccgtttatg ccaatgggct ttggcggcgt 1024021 gttcagtgca gcggcgctcg tattctttgc ttttatcgga tttgacgctg tatcctctgc 1024081 tgcggaagaa acgaaaaatc ccgcgaagga tctgcctaaa ggcattattt tctctttact 1024141 ggtctgcacg attttatatg tcaccgtatc agccatcatg actggggtta tcccgtttgc 1024201 tcaatttgcg ggtgtggatc atccggtttc tcttgttctt caaagcgcag ggcaaaattg 1024261 ggtggcaggc atcattgata ttggcgccgt gttgggaatg acaacagtta tgctcgtgat 1024321 gctttacggg cagacccgcg tcatgtttgc catgtcgcgt gacggacttg tgccgggttc 1024381 actttctaaa gtgcatccaa agcacaaaac accttatgta gccacttggt ttttcggaac 1024441 gatgtcggcg cttctcggct cacttgttcc gctggatgaa cttgcaaagc tggtgaacat 1024501 cgggacgttg tcggcatttg tcctgatttc tgtggcagtt atcgttttga gaaagaaaca 1024561 gcctgatctt ccgagagctt ttaaatgccc gggagttccc gtgatcccag gcctggcgat 1024621 tctgttctgc ctgttcttga ttttaaatct gggatgggtg acgattgtcc gcttcctagt 1024681 gtggctgtta atcggcttgg taatctattt cctgtattca agaaagcatt caaaattaaa 1024741 tcaataacct tttgataaag agagcggcca tacaggccgc ctcttttctg ttcttggcaa 1024801 atgaatctat agaaatgaag acaaaaataa gagataatat aggctggaaa ggaagtgacg 1024861 tttattgtct gagcaaaaac cagtccaatg ggcttcgaaa attggtttcg tcatggcagc 1024921 ggccggctcg gctatcggct tgggcgcgat ttggaagttc ccttacgtag cggggaccaa 1024981 tgggggagga gccttttttc ttatcttcgt gttatttacc atcctcttag gctatccgct 1025041 tttggtgggg gaatttattt ttggaagacg gaaccagacg aatgccattg atgcatataa 1025101 aaaagaagcg ccgcgatcag cttggtttct tacggggtgg atcggcgtag cggcgtgttt 1025161 cttagtgctg tcgttttaca gtgtaatcgg gggatggatt ttgctgtata tcgtgaaaac 1025221 agcgtcagga tcactgtccg ggctttctca agcacagtat ggcgctcttt ttgcttctat 1025281 tatccaaaat ccggtgcaga cgctcgcggc tcagcttgtc tttatggcac tgactgtact 1025341 cgttgtcgca agaggggttc aaaaagggat tgaacgggta agcgcggtga tgatgccgat 1025401 tttgttttta ttgtttattc tgctcgttct tcggtctctt acgcttaatg gtgcaatgga 1025461 aggcgtaaag tttctgcttg tgcctcattt cggcgatctg actccggaat ccatattatt 1025521 cgcgctggga caggccttct ttacgttaac actgggggtt tcggtgatgg tgacctacag 1025581 ctcctatttg ccgaaaacac aaaatatccc tcgttcggca gcctccattg tcttgatgaa 1025641 tatcattgtg acactcttgg caggtttggc tatttttccg gcggttttct cattcggttt 1025701 tcagccaaat gaaggaccga cattgctgtt tacagtgctt ccggccgttt ttgaacagct 1025761 tccgttcggc acattgtttt ttatcggctt tctcgttgca tttttatttg cagccttaac 1025821 ctcagcattt tcgatggttg aaattatcgt tgccacaatc ggaaaagggg acgaaaagaa 1025881 gagaaaaaaa ctgtcatgga cgagcgggct tttgatcttt ttggtcggaa tcccatgctg 1025941 cttgtcttat ggcgttttga gtgatgtgca cctatttggc aaaacgtttt ttgatattgc 1026001 cgattttacc gtcagcaatg ttttgatgcc ttcaggcgct ctgttaattt ctctatttat 1026061 cccgctgaaa atttcgaaaa gcgaactctt ggctgaaatg cgaaatggat caaatgcagg 1026121 taaagcattc ttttacacat ggttttattt gcttcgtttt atcgtgccgc ttgccattat 1026181 tatcgtgttc ttaaatttaa tcggaatttt atcattttaa aaaacaggct ccgtttccgg 1026241 ggcctgtttt ttatttaata agatgatatc aacggtgccc atgccgtttt cagtttttgg 1026301 atgccgagcc tgatgtcctc ttctgacaaa ccgccataac cgattaagac agaagtaaaa 1026361 ggcgtctgtt ctatatatga gggagacacg ggatagaggg ttacaccgtg gtcagcggct 1026421 gcttgtattg cttcttcctc acttgctgga aacaaaaggc gcagcagaat gtgaagcccc 1026481 gagttcttac cgagaatctc aacggtgttt cccagttcag agcgaatggc ttctaacagg 1026541 acagcgtgtt tttttcggta taagcttctc attctattta tgtgtttttg ccactctccg 1026601 gtttcgatga agtctgccag tgccaattgc gagtgggcag aaacggtctg cttcattaac 1026661 tgaacattgt tttggatcgg ttccatgagt tcagggggca caatcatgaa gctgagccgc 1026721 aaggaaggca gaagtgactt tgaaaaagtg cccagatata tgactctgcc attcggatca 1026781 agaccctgta aagacggaat gggatggccg ctgtagcgaa attctccatc gtaatcatct 1026841 tctataatga atgaatttgt ttctgccgcc catgccagca gctcctgtct gcgggtaatc 1026901 gtcataatgg tcccaatcgg aaactgatgc gaaggagtcg tatacatgag ataaggattc 1026961 tgacggtaga gctcatccgg caggacgcct tctgcatcag aacaaatcgg agtgacatcc 1027021 atgtgatttg cttcaaacat ccttcttgaa cggtgaaagc ccggttcttc aaagccgatt 1027081 tttgtacctg gctttagcga aaggcaaaga ttttgcagaa gcacggtggt tcctgcgccg 1027141 atgataatct ggccgggttc acaatttact ccccgagaca gcctgacgaa tcgggcaatc 1027201 atgtgcctga gttcgtattc tccttgaggg tcgccagagg tgtgaaacga tccggaatag 1027261 cgatcaagac tttttactat gctttttctc catgcgttaa agggaaagag ggtcggatca 1027321 acgctgccct gatggaagtc aatagcaggt gcgttttttt gatgtaatcc cggctgtaca 1027381 gactgctgaa aatggtcagg agctgtcggg aatcctggtt ctacttccgc cgcgaaccag 1027441 ccgattttcg gcttgctttt gacatagccc tcagcagtta attgctcata agctcgttct 1027501 atagttgccg tgctgacatc gagcaagctg gagagcctgc gttttgacgg aagtcttgtt 1027561 ccctttgtga ttcgcgcatg tgaaatttct tgtttaaaaa aggtataaag ctgttcatac 1027621 agcggtgttt tgctcttttt atcaagaaac ggcgtaatat ccatctcatg tctcctttgt 1027681 agctggcatg gtcatttttt ctgatattgg ctatttggca aatgccattt attagctatg 1027741 atcattgtaa cgaaaggaaa ggggattgag aagatgatcc atatgaaaca attaacctcg 1027801 aaagaagaat gggctgagtc gtatccgatt atgagtgaat tgagaacaga actggatata 1027861 gagacgtatt tacaaaggct tgaagcctgt gtgcagaaag aatcgtatat gctgtttgcc 1027921 ttatatgaaa atacagcaat cagagcgctg tgcggggctc tgccgagagt ttccattcat 1027981 aaaggagagc acttgtggat tgcggatctt gttacaacgg caccttgccg atcaaaggga 1028041 tacggcaaaa tgcttttgga ttatgcctca gactgggcga gaaaagccgg actcggtttt 1028101 gtcagtcttt catctggcct tcagcgtaaa gacgcacatc gattttatac agataaaatg 1028161 ggttttacta tagaaagtta tttgttccga aaaccggtat aacgaaaaaa gacgcctgaa 1028221 aaggcgtctt ttttaaaagc caaactgtaa attcgtatct acagatacaa tggtatacac 1028281 acaaataatc acaaagagat taaggatgac gccgagcagg cctggacctg tgcgccctct 1028341 cttgatgaag agttcaacaa cgccgaacgg aacggcagcc atggcgaacg gaagcatttg 1028401 ataggaataa aacgtgacgt tgctgataat ggccaaattc agcaacagca gggacagaac 1028461 cgctgtcccg acagagatcc agccgaatac attgtgttct ttaaaaattc ttaccagttc 1028521 cataattcca cctcgccgac attcgctgat tttacagatt tatttttcag catgcgctgg 1028581 atttccttgg ttggccctgt aacgaccgaa ccgtatacat tgacaccgtt tttctctaca 1028641 taatctaatc ggttatctac attcaggtct ttccgttttg aaatgacctg agcccatttt 1028701 tcgtgtttgg acatgaattt cagggcgttg ataaactgat cgccattcga cttgcctttt 1028761 gtattaaggg cggccaagaa ctttgaatcc tttccaggat agccaagagg ttctgtggaa 1028821 gctgtcttat ttgtgttttt ctctgtttcg attgcgttcc acaaaaagct cacatcatag 1028881 cctttgaatt tgttatacac gtcttttgtc ggatatgcac ggtcatatga aaggtagacc 1028941 tctgataccg ttccttcagg caatgtgctt aacgtttttt ctgcttttgc ggtcgtttgt 1029001 tcagacttgt ttgaaggatg tgtaaagtaa tggccggttt tattcacttc taagtcatag 1029061 tagtttactg ccggcgcttt tactttgtta taaaacattt caacccgttc attccctacg 1029121 gcagccgtct tcgtgccaat ctgcttttgc agcgggaatt ccgtattcat tccaaatagc 1029181 ttcacttggc ttttcagtcc ggaagtatca acaagaacat tcggcatggt cagggctaca 1029241 gtgactgcgg cagtttccat aaactcattg ccggtgctgt gttttccacc cattccgtaa 1029301 tagaggtagc ttcccagcgt acaaagcggc aaaatcatca atgtcgaaat gacggcaagc 1029361 acagaaattc gcaaataaga cttgcgtttg ccgtaggcta aaatcgcttt ttgtttttca 1029421 ggactgatgc tgagatccca atcgttatcg tcctctagtt cgctgtcaat cagttcctga 1029481 tatacttcaa gcttctcgag ttcttcctca aatgcagtca tttcctggtc gctcatttcc 1029541 ccatttttat attgatcaaa acgcttttta aattcttcat tcatcattaa cacctctatt 1029601 ataaagtgct ttcagccgct gtctggcacg aaataaaaca cttttaaaat tcgcctctga 1029661 aatattcata atatgggatg cttctttgta gtttaactct tttaaataat atagcgttaa 1029721 ggcctcccga taattatcgg ggagctcgga catataacca gtcagcactt cctttatctc 1029781 tacctgatgg gcaggacttt gaacagcatt ttgaaagagg cttccgatta agtcatcaga 1029841 aatggttact tctttcttat gctttctgac gtaatcaatg aaggcgtttc gcgccacttg 1029901 aaaaagccag ggctttactt tgctgtgatc ataggagtga atgtgtatgt atgcccgcat 1029961 aaaggtttcc tgcagtaagt cttcagcaag atgcttgtct tttgtcatgg agagcaggaa 1030021 cctgtaaaca tcattcatgt acatttggta aatttcatcg atcgtcactg ccttttctcc 1030081 cctctatgtt atacacgcat aagaaaggtt taaagttgca cattacatgc aaacggcttt 1030141 tttataccta atcaaacacc attactatat agtacccaaa aatggccgca aaagatagtg 1030201 cggagaaagg tttaacattt tttccagagg ggaaaagata gtgaaaaagt gaaggagtgg 1030261 cacaatggaa tataccagta tagcagatac aggaatagaa gcctccagaa tcggcctcgg 1030321 cacatgggcc attggcggaa cgatgtgggg aggcactgac gaaaaaacat cgattgaaac 1030381 aatccgcgcc gctcttgatc aggggattac actgattgac accgcaccgg cttacggctt 1030441 cgggcagtcc gaggaaattg tcggaaaggc aatcaaagag tacggcaaaa gagaccaggt 1030501 gattctcgca acgaaaacgg ctctggactg gaagaacaac cagctgttcc gccatgcgaa 1030561 cagagcgaga attgtagagg aagttgagaa ttctttgaag cggcttcaaa cagactatat 1030621 tgatctttat caggtgcatt ggcccgatcc gcttgtgcca attgaagaaa cggctgaagt 1030681 catgaaggaa ttatatgatg cgggaaaaat ccgggcgatt ggcgtcagca atttttcaat 1030741 tgagcaaatg gatacatttc gcgccgtcgc acctctccat acgattcagc ctccatataa 1030801 tctgtttgaa agagagatgg aagagagtgt ccttccttat gcgaaagata acaagataac 1030861 aacattatta tacggcagtt tatgcagagg gctgttaaca ggcaaaatga ctgaagaata 1030921 tacatttgag ggcgatgatc tgcgtaatca cgatccaaaa ttccagaagc cccgctttaa 1030981 agagtatctt tctgctgtga atcaattgga taagctggcg aagacacgtt atggaaaatc 1031041 agtgattcac ttggctgtca gatggatctt agatcagccg ggagcggata tcgctctttg 1031101 gggagcaaga aagcctgggc agcttgaggc cctatctgag attacaggct ggacgctgaa 1031161 cagtgaagat cagaaagata tcaatactat attggaaaat acgatatcag accctgtcgg 1031221 accggagttt atggccccgc cgaccagaga ggaaatataa caaaagctga gggcgaatcc 1031281 tcagcttttt ggcgtttaaa cgagagaaat cttaaaaatt agtaccaggt aataaaaaat 1031341 attgttataa tagatgacag aaagaatcat tgattacgac aaaggaagtg cgatatgtat 1031401 aagttttgtg caaatgcttt aaaagttatt ctttctcttc gcggaggagt gaaggtgtat 1031461 aacaaagaaa accttccggc cgattcaggt tttgtcatcg cgtgtacaca ttccggctgg 1031521 gttgatgtga ttacactcgg agtcgggatt cttccttatc aaatacacta catggcgaaa 1031581 aaagagcttt ttcaaaataa atggatcggt tcgtttctga agaaaattca tgcctttccg 1031641 gtagatcggg aaaatcccgg gccaagcagt attaaaacgc cgattaagct gctgaaagaa 1031701 ggagagatcg tcggtatctt cccaagcgga acaagaacct ctgaggatgt gcctttgaaa 1031761 agaggtgcgg tgacgattgc gcaaatgggg aaagcgccgc ttgtccccgc tgcatatcag 1031821 ggcccttcaa gcggaaaaga attattcaaa aaaggaaaaa tgaagctgat tatcggtgag 1031881 cctcttcacc aggctgattt tgcccacctg ccttcaaagg aaagacttgc agcaatgaca 1031941 gaggctttga atcagcggat taaagaacta gagaataaac ttgatcagct ataaggcgtt 1032001 ctgagagatt gtcctgaaac tgtgaaaata agaaaagcac cctatacaag gtgcttttct 1032061 tattatgctt cctgctggtt agctgtctcc agaagttctt cttcttgaag ctttttcact 1032121 tcaatatatg cgacgtggtg gccgtcaatt tcattaatga tgaattcgca gccctcttcg 1032181 atgatggaat catctttttc aacatcgtat ttttgagtaa ggaaccagcc gccgattgta 1032241 tcgacttctt cgttctctaa atggatgcct agcaggtcgt ttacttggtc aattaacact 1032301 tttccgtcaa gaatataatg gccttcgccg attttgcgga tttcgctaat ttcatcaata 1032361 tcaaattcgt cgcggatttc accgacaatt tcctcaatga tgtcctcaac cgtcacaagc 1032421 ccggcagtac cgccgtattc atcagacaaa atggccatgt ggaccctctc tttttgcatt 1032481 ttgacaagca ggtcttggat cggcgcagat tcaatgacat gaatgatagg gttgacgaat 1032541 tgagaaatgg tggaatcaac agatacctca ccgctgatgc aggcggtcag cacttcttta 1032601 atgttaataa ccccgataat gttatcttta tcgccctctt ccacagggta gcgggtatat 1032661 ttttcaatct gaatgatgtc catcatttca gaaatcttga tatcatgcgg aaggctgaca 1032721 atttcggtcc gcggaatcat aatttctttc gcgagcctgt cgtcaaattc aaagatttta 1032781 ttcacatatt taaactctga ttggttgatt tcaccgcttt tatagctttc agacaaaatg 1032841 attcgcagct cttcttctga gtgagccagt tcgttttctg aaacggtctc caggccaaat 1032901 gctttggtca ataaccgtgc ggaattgttc aaaagccaaa tgaatgggaa cgcgatgcgg 1032961 taaaaccaaa tcagcggttt cgcaaacagc atagacactg cttccgcctt ttggatagcg 1033021 actgttttag gtgcaagttc tccgacaaca acgtgtaaga acgtgataat ggcatacgca 1033081 aaaataaacg atatgacatg tgaaagggaa cctggaacgt tcatttggac gaaaagcggg 1033141 tgaagcagcc tttcgatcgt tgattcacct aaaaccccta atccgatgga agtcaatgta 1033201 attccgagct gacacgcaga taaatattca tcaagatgcg tggtcacttt ttttacggct 1033261 attgctgctt tatttccttc cgcgatcagc tgatcgatcc gtgagcctct gattctgata 1033321 atggcaaact cagatgccac gaaaaatgcc gtcagggcga ttaaaacagc aactaaaatc 1033381 aaattcacta tgtccaatta gaaccttcac tctagcaatg agaatgaagg taacacctcc 1033441 tgttagataa aatggtttta acttaacagc agcataaatg attggaacac ggcgagcttt 1033501 tcaggcggga gtttgctttt cagcttgtca cgatcctcgg gcttcagccg ttcaaaccga 1033561 tgcaagattc cggagatgtt ttgattcata tgatcaattt ctaatgccag atttccaatt 1033621 tcatcatcaa gtttagctga agagggaaac tggttctcca gtcgatcttt aatatcggac 1033681 agggccaatc gctgcttctt gcaatctaca ataaatataa gtcgtttgag tgcattttcg 1033741 tcgtagtaac ggtaatttga acaggatctg gccggcgtaa gcagaccgag attcgtataa 1033801 taatcaactg tccgtttcgt tactccggcg agtgccgcta gttcactgat gcgataagtc 1033861 tcagccccat ctatatccct cccaaccatc acgttatagt tatgagaata gtttaatata 1033921 tgaacggtgt cttgcacaag tttattgttt tttttagacc ggaattggaa gttgtggaat 1033981 tcatcatctg attgaagtaa cataggaaga tagaattttc aaatttttat atgcggaagg 1034041 gacagatgaa attggctggg ttatcccggg aagttgaaga aaacttaaat aaaggatcat 1034101 ggattcgcaa gctgtttgat gaaggtgcaa ggctgaagaa ggagttcggg gaagaccagg 1034161 tatttgattt ttcactcggc aacccgattg ttgaaccgcc tgaagctttt aagagagcgt 1034221 taatagagga agctgaaaaa ggcagccacg gatacataca aaaccaaggg cttcttgcag 1034281 cgagagaaaa agtcgcgcaa tttctgggct cgcgttttga agctgatttc tcagcggagc 1034341 gcatcgtcat gacggtgggc gcgggaggcg ctttgaatgt tgcgttaaaa agcatcgtaa 1034401 accctgggga agaggtcatt attcttgcac cttattttgc cgaatataag ttgtatattg 1034461 agaactacgg gggaaaagcc gtcagctgcc cgttgacaag ccggtttgag atcgacattg 1034521 aagcggtaag gcaatcgatc actccacaga cgaaagggct gattctcaat acaccgcata 1034581 accccacagg cactgttctc agccagaaaa atatagacga tttaggcgct ttattaaaag 1034641 aaatagaaga gaagagcggc cagacgattt atgtgctgtt tgatgaaccg tacagtcaat 1034701 taatctatga tgaagagctg gcaaatccgt ttcaatcgta ccatcgtgtg atattggcca 1034761 gctcattcag taaagatctc ggcatagccg gagagcggct cgggtatatc ggattggaca 1034821 gccgaatgcc ggatgcggac cttttgatca acgcttttgt gtattgtaat cgaacgcttg 1034881 gatttgtgaa tgcccctgtc atgatgcagc gggctgtggc acgaatggat gatttaagag 1034941 tagacgcgag cgcttataaa gagcgccggg atttaatggt agacatttta aaagaagccg 1035001 gttttgaatt tgaaatgcca aagggaggtt tctttgtttt tccgaaatcg ccgattgaag 1035061 atgaagttgc attttgcgtg catgccgccc aaaaatacaa attattaatt gtgccgagca 1035121 gcggttttgg aatgagcggg catttccgat tatccttcag tgtgccgatc gagcagatta 1035181 aaaactcacg ggacattttc atttctttat ataaagattt tgcttaagaa ggcaaagaaa 1035241 agaaaacagt tttcaaggct gttttctttt tatatccgca aaatccttcc tcttccaatc 1035301 cagacaggcg cagaattgac aagcaggcat gcagttaagg ctttcttcat gataaaagtc 1035361 taaaaattaa aaatcatttt tggaatgagt tgtgttacaa taaaatatac aatttataat 1035421 caaactttga cttttggagg tggtatgatg gggccctctg cttaggcaac aatacaccgc 1035481 gtacctcaat gttaaggaaa aatgattata tcaggaggtg actccttatc ctttgttgag 1035541 aggatagggt taaatggacg atattgacag tctgatttta attggcgtgc tcattgcttt 1035601 aaccgcgttt ttcgttgcaa gcgagtttgc gattgttaga gtgaggagat ccagaataga 1035661 tcagcttatc acagaaggaa acaaacgggc gatactcgca aggcgtgtca ttacagattt 1035721 ggatgaatat ttatccgcat cccagctagg cattacattg acatcaatcg ggcttggcgt 1035781 actgggtgag ccggcctttg aacggctgct gcatccactg tttgaaccgc tcggcttgcc 1035841 ggactcggtt tcacatgcag tctcttttgc agtcgcgtac ggcttgatca cgttcctgca 1035901 cgttgttgta ggtgaactgg ccccgaaaac ggtcgcgatt caaaaggcag aacagctgac 1035961 tttactgata gcgggccctt tgcgtttatt ctatttgctc ctgtttccgt ttatttggat 1036021 cctcaatgga tcggcgcggc ttttatgcgg gatgttcggt ttgaagcctg cgtcagaaca 1036081 tgatggttcc cattctgagg aagaactcag gatgctgtta tctgagagtt taaaaaacgg 1036141 agagattaat ccgtctgaat ataaatatgt gaataagatt tttgaatttg ataatcggat 1036201 cgccaaagaa attatgatac cgcggaagga aatggctgct gtgtcaactg agatgacgat 1036261 ggccgagatg cttgaagtca tgctgaagga aaaatacacg cgctggccag tcacagatgg 1036321 agacaaagac agtgtgctcg gtttggtcaa tacgaagcat ttgttttctg atttgctgtt 1036381 tatgacagaa gaagaacgaa tgaagatgac gatccatccg tatgtgaggc cggtcatcga 1036441 agtgattgaa acgatcccgg ttcatgactt gctgattaaa atgcagcgcg agcgcattca 1036501 tatggctata ttgtcggatg aatacggagg aacctcggga cttgtgacga cagaggatat 1036561 tcttgaggaa attgtcggag agatccgaga tgaatttgat gaagatgaac agccgctgat 1036621 ccaaaagctt ggcgacggcc attatgtgat ggatggaaag gttcggatcg atcaggtgaa 1036681 cagccttctt ggcgcatcga ttcaagaaga cgtcgatacg atcggcgggc tgatattaaa 1036741 agaaaacatc gatattgagg ctggtgaatc cattcgcatc ggttcatata cgataaaggt 1036801 gctgaagatg gacggccgat taatcaagca aatcgatata aaagaagaag ccggcaacac 1036861 aaccgggatt acggcgcacc acaagctgcc gctgcccgag cctgtgatgc tgaacagtgc 1036921 aaccttgagc gagaaataag ctcaaggttt ttttatattg tgattgtcca gccgcaccaa 1036981 aatgcaaaaa gcgacccgca aagtgtcagg acgatgtaca agatgctttc ttttacacgt 1037041 ttggccataa ggagttgaat agtttcaacg ctgaatgtgg aaaaggtcgt aaaggcgcca 1037101 aaaaaccccg tgccaatgat aagcgagacc gaagcatttg caacgtgaag tcctgtaaat 1037161 attccgagcc cgagagctcc gagaatattg actgtcagta tgccaatggg caggctgaga 1037221 cctttggttt tggcggttat gacattgcca agccagaagc gaagcattgc gccaagtccg 1037281 ccccctatga aaatacccgc tagtgtcatt tttcctgcag cccctttctt tgctgaatgc 1037341 ctgctatgcg ccgtcccaca aaaacaccaa tcagtgcaaa tatgatccct gatatcaatg 1037401 aggctgccac atataaaaga gccaatgagg gttgtccttg caaaagcatc actgtttcct 1037461 tagaaaacgt ggacattgtt gtgaagcctc cgcaaaagcc ggtgcctaaa aaagccgaca 1037521 gcagaggccg ttttgccccg atcataaaaa atccggtcaa aatgcctaat agaaggctgc 1037581 ctgccgcatt ttccagccag gttgccgccg ggaactgacc ggtgtgtatc cataagttta 1037641 atccgtatcg gaggcaggcg ccaagcgcgc ctccgataaa aaccgcgcta tatattttca 1037701 tgtttgccat cctttatgat gaaatccggg taatctgtaa cgatgccgtc cacgcccatg 1037761 gcttgtaatt ttgccgctgt cttttgattg ttgacagtcc atgcaaatat gtttaagcca 1037821 tttttattga tggagccgat catcagacgg ttaagccgtg tgtgttttat attgacatag 1037881 tttgcaaaag agcggaaggc cttcatctga tttctggaca gcatgccaaa gttgggcctt 1037941 gtaatgaccg ctgtcggaat cgaaggataa agctcgcgga acctttggac ggagcggaac 1038001 tgaaaggatt gaacaatatt attgatagaa aaagaaaatt gccctaatag ctgtcccacc 1038061 tcttcttcaa ttccgacttg agacggatgg ccttttagtt caattaaaag gccgattttt 1038121 ttgtggtagc gcttgagcac cgcttccagg gttggaatac gctctccttg aaaagcggga 1038181 ccgtaccagc ttcctgcatc gagtttttgc aattcctcca aggtaaaatc cttaacaaag 1038241 cccgatccgt ttgttgttcg gtcaaccctg tcatcgtgta tcacaacaat ctgcctgtct 1038301 tttgtaagct ggacatccag ttcgatcata tctgcattca ttttcaccgc aaggtcaaat 1038361 gcggcaatcg tattttccgg agcgtagccg gatgctccgc gatgggcaat gatgtacaag 1038421 ctaagtcagc tcctcgtatg ggcatttctg ttattgtatc aaatccatat atgcaccgcg 1038481 atacaaactg gtgaattttt tctgccatat cggaatggtc cgggctgagg aatgcgtata 1038541 actaaaaaaa gacactcagc gtatcagaac acatttcgtc agaaaattag gtctttcgac 1038601 atgttcacaa caaaatatga tcctttataa tagcaaaaaa ggaggcgaga tcatgggaaa 1038661 agggagaatc agagtggagg aaagaattaa agccgaaacg gatgctgaaa tgcaaaaagc 1038721 aactctcctt gatcagacac aaacgaaaaa aggtaagtga ctgtccctat tgaatctggc 1038781 tgatagatga attgagaaat gaccccggcg tttcgccggg gttttgtgct gcataagaca 1038841 tttaaatgaa catccttacg aatattttag tataataaac aattgattgg gatagagggg 1038901 agacagtcat gccggattat ctgcagcagt attttacgct tgataacatc atacaaatcg 1038961 gcatcagctt ggcgattttg ctggtgtttc ttatacttag aaaattattc acaagatatt 1039021 tttttaacct gctttttaat ttgacaaacc ggccgaaaac agaaattttt aaacaggtgg 1039081 ttctggcgtt tgataagccg gccagatggt tttttgttgc ccttgggctg tttttagcga 1039141 tccggtattc accgttttta gatgagcaaa tgccggtcat cagcaaaata taccgctcac 1039201 tgattgtggc gctcttgtgt tggggtcttt gtaatttgac cgcaacatcg tcgtttatct 1039261 tccataaggt gaaccagcgc ttcgagcttg acatggatga cattctggcc ccgtttttat 1039321 ccaaattgct ccgttttgtg atcattgcgc tcagtgtcag tgtgatcgct caggaattca 1039381 attatgatgt caacggattt gtagcgggcc ttggtcttgg cggactggct tttgcgcttg 1039441 ccgcgaagga taccatcagc aacttcttcg gcggtattat cattattact gaaaagccgt 1039501 ttacaattgg tgactgggtg gagacgtcga cagtaacagg atcagtcgag gatattacct 1039561 ttaggagcac gagattcaga acagcacagg gggcgcttgt aacggtgccg aactctacgc 1039621 tgtcgatgga agcgatcacg aactggacaa gaatgaccaa acgccagatt acgttttcca 1039681 tccatgtgtc ctacgctacg ccgattgaga accttgaacg ctccattcat tctctcagaa 1039741 caatgctctt agagcatgag ggcgttgata atgaaataat catggtcaac tttgatacgt 1039801 ttgccgacag ctactacaat ttatttttta acttctatac aaaaacgacg gtttgggctg 1039861 aaaaccttaa tattagagag gatatcaact ataaaattat tgagatttta ggtgcagaag 1039921 gcgttcagtt tgcatatccc ggccaaatgg ttgttgtcaa gcaaaagcac gaaagcgacc 1039981 aattccaggt gaatctaaat aaagaggaaa aggaacgggc ttaaaagaga gacttcgtct 1040041 gacagaggcg gagtcttttt catggtaaaa taagagaaaa aggcggtgtt gagttggaaa 1040101 cattcaaaag tattctacat gaagcacaga gaattgttgt gctgaccgga gcgggaatga 1040161 gcacagaatc agggatcccc gactttcgtt cagcaggggg catttggacg gaggatgcct 1040221 caagaatgga agcgatgagc cttgattatt ttttaagtta tccgcgtctg ttttggccca 1040281 aattcaaaga attgttccag atgaaaatga gcggcagctt tgaaccgaat gaaggccatt 1040341 tgcttttagc tgagctggag aagcaaggga agcaggtcga tattttcacg caaaacattg 1040401 acggtcttca taaaaaagcg gggagcaggc atgtgtacga actgcatggt tctatccaga 1040461 cagcagcttg tccggcatgc ggcgcccgat atgatcttcc ccatttgctg gagcgggagg 1040521 tgccggagtg cacggcggcc ggaaacaatg gggacatttg cggaacggta ttaaaaaccg 1040581 atgttgttct ctttggcgat gccgtcatgc actttgacac cctttatgaa aagctggatc 1040641 aagcagatct tttattggtt atcggcacgt ctctcgaagt ggctccggct agatttgtgc 1040701 ctgaggatgc aagcctgatt cccggcatga agaaagtcat cataaacctt gaaccaacgt 1040761 attgcgacag cttgtttgac atggtcatcc atcaaaaaat cggcgagttt gcccgaagtt 1040821 tgggcatgaa aaagtgagcc gctttatgcg cctcactttt ttattcatga acaggaacca 1040881 ttgtgtcctc taacactccg aaggaatagc ctttttcttt taatttattg attagtaccg 1040941 gcagcgcatt tacagtagca ggaagatcat gcatgagaat tacatttggg cggcttgaag 1041001 agctgtgttc catattctca agctgctgta atacggcggt cacatactgt gaattccggt 1041061 atttccagtc catgctgtcg atcgtccaat cccagtacac aaacccatct ttctccagat 1041121 tgcgaatttg tgaggcggtt agtgacggct tgcttccgta tggcgttctg acaagatcgg 1041181 ttttatatcc tgtaatgtcc tgcagcgtgt cacgcgcctc ctgcatttct tttagcggag 1041241 atgtcggtgt ttgatagaac aatctgttat tgtgggtaac gccatgtaaa ccgagtgcgt 1041301 ggccttcctt ttctgctctt ttcacagcct gcttgaattc gttcatccgc ggtgacagca 1041361 taaaaaacgt cgcttttaca tcagcgcttt tcagtacgtc gagcaagcgg gttgtaacgg 1041421 ctgaagggcc gtcgtcgaag gttaagtaaa ccgttttatc tcccatgttc tgctttgtct 1041481 gcagatgttt tatcaggaga tcgggggagt cgtttttcag cttaaggctt tccttctcat 1041541 ctcgaagctg gccgtttgtt gtgacagtga cttcctttgc tttcgttgaa ctgttggaat 1041601 aacccaaaat caccataagc aaaagcagca cacataaaac tgctaaactt gcaaatttaa 1041661 aagcaagcga aactgcagaa ggagaagcct ctcctctcgt ttgtcgcata acaatctctc 1041721 cattggcata aaatctctac ataatgctgt acagcaggca gcttatgaag atgccttatg 1041781 tttacaacct atgtattacc agtcaagtat acaggaataa aactggaaag cacatagaaa 1041841 atttgtcgaa atgtcagatt ttaaggaaaa aataaactcc tttccgctat agatctcttg 1041901 atctttctgt ttttcagctt gtccaatatg gtagaattag tgataatgac agcttgaatg 1041961 acatcaggga catctcgaaa agggagggct tttatgaagg ttttagtcaa tggccggctg 1042021 attgggcgca gtgaagcatc aatcgatttg gaagatcgcg gttatcagtt tggtgacggc 1042081 atctatgaag tgatcagggt gtacaaagga gtattgttcg gcttacgtga gcatgcagag 1042141 cgttttttca gaagtgctgc tgaaatcgga atttcactgc cattcagtat agaagatctc 1042201 gagtgggacc tgcaaaagct tgtacaggaa aatgcggtca gtgagggagc ggtatacatt 1042261 cagacaacaa gaggtgtggc cccgcgaaaa caccagtatg aagccggcct cgagccgcag 1042321 actactgcct atacgtttac ggtgaaaaaa ccggagcaag agcaggcata cggagtggcg 1042381 gccattacag atgaggatct tcgctggtta agatgtgata tcaaaagtct gaatttactg 1042441 tataatgtca tgacgaagca aagggcctat gaagccggag catttgaagc cattttactt 1042501 agggacggcg ttgttacgga gggtacatcc tctaacgttt atgccgttat caacggcaca 1042561 gtgcgaacac atccggctaa tcggctcatt ctcaatggaa ttacacggat gaatatttta 1042621 ggactgattg agaagaatgg gatcaaactg gatgagactc ctgtcagtga agaagagttg 1042681 aaacaggcgg aagagatctt tatttcgtca acgacggcag aaattattcc ggtcgtgacg 1042741 ctcgatggac aatcgatcgg aagcgggaaa cccggaccgg tgaccaaaca gcttcaggct 1042801 gcttttcaag aaagcattca acaggctgct agcatttcat aaatgaacga agaaaagagc 1042861 ccgcttttta cagcggggct ctttttattt tttaacaaat ccaatcaaaa tggagatcat 1042921 tggcgatata tagaggaaga acgtaaatgg gatgtagtct atgactggaa caccaagtgc 1042981 gctcgccata aatgcgccgc tgacgcccca aggaatcaat gggttaatta atgttccgcc 1043041 gtcctctaat gatcttgtca gaaattttcg ctggatgttt cgtttgtcat ataaagattt 1043101 aaatgattgt cccggtatta atatcgataa atactgttcg cccgttgcca agttgacgcc 1043161 gatgcttgag cagacagttg ctgcaacaag acggcctttt gagcggatgc ctttcatgac 1043221 gccttccaat agtgcagaaa tcaatccgat tttctccatc aatccgccga gtgcaaaagc 1043281 aatcataatg agagagacag agcccatcat ggattgcagt ccgcctctgt taataatttt 1043341 agcggctgcc tcattgtcag tttcgaaagt tgtgccattt tgtaaagctg tcataaacgc 1043401 ctgcaggctg ctgtagggta caaaaatagc agtcaaaatt cccgaggaaa taattccggc 1043461 agtcagaacg gggattactg atacccgttt cattgccagc aaaacgacta agagcggaga 1043521 aagaagggcc cacggtgtca cgtttgcagc atcttttatt ccggttatga cctgctgaat 1043581 attatcggtt gaagcagcgt ccgctgacac tgatgaaccg agaaagtaaa acagaacgac 1043641 agtgatgagc aaagctggaa tggttgtgcc catcatatgg cgaatgtgtt caaagattgg 1043701 tatttcgcct attccggctg caaagttggt tgtgtccgac atcggcgaca ttttatcccc 1043761 aaaacaagcg ccgcatatga ctgcgcctgc tgtccattca agcggaacgc cagccgcgct 1043821 cgccacgccg atcagcgcta ctccgattgt gcttacagtt gtcagacttg agccaacaag 1043881 tgtgctgatg atcatacatg aaaacaaagc agtcaacaga aggtggcttg gttcaataaa 1043941 ggatagggca taaactgtca tagtcggtat tgcgccgctg tacatccagg cgccgattaa 1044001 gatgccgatc agcgctagaa caataatcgg ctgtacgccg tttttgatcc cgtctacaat 1044061 ccctttttca atgctcttcc agggaaatcc aaaccataaa gctgctgctg aaagcatgac 1044121 aacacttaaa aacagcggga tatgaggttc tacatgaagc aagaataagc aagaaataat 1044181 aatgcacaac atgaatataa ataaaccgac ggctaacgga aacgtcagct ttttttgaga 1044241 atccaaaata acaccccata tttatcttta atgcttttgt gcttttgggc acgaaagcat 1044301 tataacagaa aaaaacgaaa atctatgttt tttcacaatt atgaatataa aagaagtgag 1044361 cacagggcgt gctcacttta caatcaggac gggtatatcc gatttcgctg aaagcttttc 1044421 acttacactt ccgaatatta gctttttcag cctgttttgg tctctgcttc cggttacgat 1044481 catatcggca gaaatgcggt ttgcatgctc gataattgat tcagccggat cgccttctaa 1044541 tatatcgata tctccatctg cctgctgttc attcagcatc attctggctt cggcgatgac 1044601 ttcttccgta cggtcttcat agatcattgg ctcaggtgat gttacatccg atatcagcgg 1044661 atcaggaaca cttgtcatgc ctccgctgat atagcttgcc tcagctgcgg gtctgggcgg 1044721 gtcgatgacg gtctgattgt ctttcatatc atgtgaatgg gcgacggtaa tagcggcatt 1044781 tacggtttta gcaagatcaa tggctgtcag aagcgctttc ttactatttt cacttccgtc 1044841 aaacgcaaca atgatacggt cagcatggaa catccttctc accctttcaa agcgtcttac 1044901 aacactacta cccgaatttg agcacaatta accttttcct attcaagtaa tgattgacaa 1044961 taaaaggttt tgtttatatg atgataaaaa gatgaaatca gaatggaagg agggtttgct 1045021 atgccaagga atttgcgtgt ttatcaaaca gtttcatatt ggcgcggcaa accttttgtt 1045081 ctgttttcgt gaacggtttt ttaggtcgga ccgcgcgctg aaaagcgctg tgcgtaacat 1045141 atcggttaaa aaaggcatgg agctgacgct tcatgccttt tttatataca aaatctaagg 1045201 aaagacaggt gtatgggatg tgaagacaaa tacagaggcg agggcagttc gtgccaaact 1045261 ggatgaaaaa agctgcaagg aaaaaataga aggcggctga tgaggagatg gggatagatg 1045321 ttttcagttt tgaaaaagct tggctggttt tttaaggcgt actggctgcg ctatacgatt 1045381 gcgattgtcc ttttattagc agtcaatgtc attgaaatgt ttccgcctaa gctcttgggg 1045441 aacgccatag atgatatgaa agcaggggca tttactgcgg aagggctgct gttttatatc 1045501 ggtatctttt ttgtgctgac ggcggccgtg tatatcatgt cttatttttg gatgcatcag 1045561 ctgtttggcg gagcgaatct gatggagaaa attcttcgta cgaagctgat ggggcatttg 1045621 ctgactatgt cgccgccgtt ttatgaaaaa aaccgaacag gcgatttaat ggcacgaggg 1045681 acaaatgatc ttcaggccgt cagtttaacc acagggtttg gcatcttgac gttagttgat 1045741 tctacgatgt ttatgatgac gatctttttg acaatggggt ttttgatcag ctggaagctg 1045801 acctttgccg ccattatccc gcttccagtc atggcgattg caatcagtct atatggaagt 1045861 aaaattcatg agcggtttac tgaggcccaa aacgcgttcg gggcgctgaa tgacagagtg 1045921 ctggaatctg tttcaggcgt gcgggtgatt cgcgcgtatg ttcaggaaac aaacgatgtt 1045981 cgccggttta atgaaatgac cgctgatgtt tatcagaaaa atatgaaagt ggcttttatt 1046041 gattcactgt ttgagccgac ggtaaaactg cttgtcggcg caagctatct gattgggctc 1046101 ggctacggag cgtttcttgt attccggaac gagctgacgc ttggagagtt agtgtccttt 1046161 aacgtttatc tcggcatgat gatttggccg atgtttgcaa tcggtgaact cattaatgtg 1046221 atgcagcgcg gcaatgcgtc attagatcgg gtaaatgaaa ctctttctta tgaaacggat 1046281 gtgacagatc caaaacagcc cgctgatctt aaagagcctg gagatatcgt tttcagtcat 1046341 gtcagcttta catatccaag ctcaacaagt gacaatcttc aggatatttc atttacggtg 1046401 cgaaaagggc agactgtcgg gattgcaggt aaaaccggga gcggaaaaac gacaattatt 1046461 aagcagcttt tgcgccagta tcctccaggt gaagggagca ttacattttc aggtgtaccg 1046521 attcagcaaa tccctcttga ccgtctccgc ggatggatcg gatatgtgcc tcaggatcat 1046581 ttactgtttt cacggactgt aaaagaaaat attttatacg gaaaacagga tgcaactgat 1046641 aaagaggttc agcaagccat tgccgaagca cattttgaaa aagatttgca catgcttccg 1046701 tccggtctgg agacaatggt cggtgaaaaa ggcgtggcac tgtcaggcgg gcagaaacaa 1046761 agaatttcga tcgcgagagc actcatggcg aatccggaaa tcttgattct ggatgattca 1046821 ctttccgctg tagatgccaa aacagaggct gcaattatca agaacatcag agaaaaccgc 1046881 aaaggaaaaa cgacatttat tttgacacac cgattatccg cggtagagca cgctgacctg 1046941 atccttgtga tggacggcgg cgtcattgct gagagaggca cgcatcaaga actgctggcc 1047001 aataatgggt ggtaccggga acaatatgaa agacagcagc tgttcactgc ggaagaaggg 1047061 ggagcagggg catgaaaata ggaaaaacgt tatggagata cgcacttctt tatcgaaaat 1047121 tgctgatcac agccgtcctt ttgctaactg ttgccgtcgg tgcagaactg actgggccct 1047181 ttattggcaa aaaaatgata gacgaccata tcctcggcat tgagaaaaca tggtatgaag 1047241 ctgcggaaaa agataaaaat gccgttcagt ttcacggcgt ctcatatgtc agagaggacc 1047301 gattgcagga gcctgtttca aaagcaaaag aagcgcatat ttatcaagtg ggaatggcgt 1047361 tctattttgt tgatcaggct gtcagcttcg acgggaatag aacggtttct gacgggaagc 1047421 tgacgatcac aaacggagac aagagccggg catatgctgc cgaaaagctg actaagcagg 1047481 aacttttcca gttctatcag ccggaaataa agggaatggt gttactgatc tgcctgtatg 1047541 ggggcttgct tgtgttttcg gtattctttc aatacggaca gcattatctg ctgcagatga 1047601 gcgccaatcg gattattcaa aagatgaggc aggacgtgtt ttcgcacata cagaaaatgc 1047661 cgattcgcta ttttgacaac cttccggccg gaaaagtcgt tgcgcggatt accaatgata 1047721 cggaggctat tagggattta tatgtcacag tgctttcaac atttgtgaca agcggaatct 1047781 atatgttcgg gatattcacg gctttgtttc tgcttgatgt gaagcttgcg tttgtatgtc 1047841 tggcaattgt gccgattatc tggctgtggt cggtcatata ccggagatat gcgtcatatt 1047901 acaaccaaaa aatccgctcg atcaacagtg acattaacgc aaaaatgaat gagtcaattc 1047961 aaggcatgac cattattcag gctttccgcc atcaaaagga aacaatgaga gaatttgagg 1048021 aattaaatga atcacatttt tatttccaaa acaggatgct gaatttaaac tccttaatgt 1048081 cccataatct ggtcaatgtc atccgcaatc ttgcgttcgt ctgtctgatc tggcattttg 1048141 gcggtgcgag cctgaatgcg gcggggattg tttctatcgg tgtgctgtac gcgtttgtcg 1048201 attatttgaa ccggttattt cagccgatca caggcatcgt caatcagttt tcaaagctgg 1048261 agcttgcaag ggtctccgcc gggcgtgttt ttgaactgct tgaagaaaag aatacggaag 1048321 aagcgggtga accggcgaag gagcgcgcgc tggggcgggt tgaatttcgt gatgtgtcat 1048381 ttgcgtatca agaaggtgaa gaggtattaa agcatatttc ctttactgcg caaaaaggcg 1048441 aaaccgtagc gctcgtcggc cataccggat caggaaaaag ctcgattttg aatcttctgt 1048501 ttcgttttta tgatgcgcaa aaaggtgatg tcttaattga tggaaaaagc atttacaaca 1048561 tgtcaagaca ggaactcaga tcccatatgg gtattgtgct tcaggacccg tacttattct 1048621 cgggcacaat cggatctaac gtaagtctgg atgacgaaag aatgactgaa gaagaaataa 1048681 aaaatgcact gcggcaagtc ggtgctgagc ctcttcttaa gaagcttccg aagggcatta 1048741 atgagcccgt gattgaaaaa ggcagcacgc tatcctctgg agagcggcag ttaatttctt 1048801 tcgctagagc tttggcgttt gatcccgcga tcttgatttt agatgaggca acggcgcata 1048861 ttgatacaga gacagaggcc gtgatccaga aggcgcttga tgtcgtcaaa caaggacgca 1048921 ccaccttcgt catcgctcac cggctttcaa caatcagaaa tgctgatcag attttggttc 1048981 ttgataaagg agaaattgtt gagagaggga accacgagga actgatggca ttagaaggcc 1049041 aatattatca aatgtatgaa ctgcaaaagg gacagaaaca ttccattgca taacgctcaa 1049101 aaacccaaaa caatcgtgtt ttgggttttt ggtttatgta gtcaataagc cagtccgaca 1049161 cggtttccga catactcacc tgtaacgagc tcacgatata aaaagtccgc agtatcgccg 1049221 accgaaatgc ttgtgccgcc ctcaggcaaa acgttacgct ccgtacgata aacgccggtt 1049281 gctgttccgt ccgggaggta agtggggcag atgattgtcc agtctaatga tgattcttta 1049341 agcatttcgt atacttttgc atgctccttg gctgcgcggg tctgctttcg tttcgattca 1049401 tttgtttcaa accggtattt tcccggttca tatcgggaat ctaggatccc tgcggtgccg 1049461 atcgtaataa gccgtttgat atgctgttcc tccataacgg agagaatgtg tgccatagca 1049521 gttgacaagg tatcatcacc atctgtgcct agacagctga tcacgatttc agcattctcc 1049581 attatttttt tcacatcttc taagcggcgg gcgttcccca tgacagttct gtcttttgaa 1049641 aggggaagat cagcatgttg agatctgatc agagcgaaaa tatcaaatct ttcatctgct 1049701 gcagcttgtg ttaaaaaggc ttgtccgacg cggccgctgg ctcctaataa agcgattttc 1049761 attaaaaaac ctcctcgcct ttcattataa aaggatgttc tcagtttgaa cagcgcggga 1049821 aagaatacct gtacaaataa acagaacgat gggaaacata ttcatgaatc atggatacac 1049881 ttacgaattg aaccagctcc caattcacaa tggtgatgaa tgacaccccg attccctccc 1049941 tttttttcta ggatatgtgg agcaggaaaa aagggtgaca aaataaagag agcgcggaaa 1050001 ccgcgccctc tatagccata tattgaattg ttattgaact ctgccgccca tttgctgctg 1050061 agcgaaagat actaaacgtt ttgtgatttc tcctccgaca gaaccgttag cgcgagaagt 1050121 tgtgtccgct ccaaggttaa cgccgaattc agaagcgatt tcaagtttca tttgatcgat 1050181 agcctgagct gcgccaggaa ctagtaagtc atttgaagag ttttggttag ccatgtgtaa 1050241 aatctccttt ttatttagta tggttgggtt aactggagtt gcaccaatct gtgaaccctt 1050301 ctcgggtgtc actgccgcct cggcgtaacc caatgctttg ccggcttgtt actacgtatt 1050361 atgttaaaat ggccggaaaa tcatgcggag aattgtgtgg taaatcttga gaaataaaaa 1050421 aagcttagcc gtttaggcta agctagtcat aaatatgaaa aagcatcagt tcatgtatct 1050481 cgtttgtaag agcaggctcg tcagcgcggg cgggaaacaa gtctccccat tcaatctcac 1050541 cgctcttatg atagatgcct tcataatggg tccctttata ataaaatgaa attttccatc 1050601 cgggcagctt ttcttttggg aacaaaggtt tccagctgaa atgagaaatc attacggcca 1050661 cgctccttac atttggtatc aattgaccta aataaaaacg gcttatgttc attgtatcat 1050721 tgtttcagaa catcattgaa gaggcctaaa tatgcagttt gtcccagctt tggataaaga 1050781 taagcccgct ttattaaaaa agcggacagg ttacgaaggc cacaatgctt ccggagatgt 1050841 gattgccttc tcagataaat atgacgcgta ttcaaaactt cttcgttttg taagagaatc 1050901 aacatgatgc aaatttggat gagaaaaaat gcttcggccc gggcgcgaat tcgcttcaaa 1050961 catccatact ttaccgttct gatcaatgcc aaaatcgaaa ccaatctccc cgataaatcc 1051021 ctcgatatga tcatgaagga catggcttgc agtcagtgcc gctgcagaaa gctttttaat 1051081 gacctcaact ctttcagcgg gatcatcgta tacttccgca agtgtcttta cagtgccgcc 1051141 gttagaaaga tgtgttgtaa tgctgttctt tccggaaatt tttacggcga ttgctgtcac 1051201 tgtccatttt ccttttctgt ttttattggt atggacacgg aaatccgctg gtttgccttg 1051261 aaattcgatg agatcaacac cttgctgaat gagaaagtcg gacgggttgt gatgtttttg 1051321 aaattctgca aggaatgagg cggcatcgga ataatcaatt gatgtaaaag ttttggcgtc 1051381 attcgtatgc tttaccgtca ggccgccatc tgttcttgtc agctgataaa tgccggtgcc 1051441 gagtgctcca tttgccggtt tgatatagac ttttttgtat gcgccacaga gctcatctat 1051501 cagctccaca gacggtgtca gctcggatct aggcaaaaag ggtgccgttc ttggatcttt 1051561 ttcgagcaat tgatgaacgt tccatttatt gaaaaacgtt ttattaaacc atgggatctg 1051621 atattcatcg atcagcctct tttttgtatg ttgcaagaga agtgaatctt caatttttcg 1051681 gttcggcaaa cggtcataaa cgacgttcgg caatggaacg atttttttct cccagccgtt 1051741 ttccctgtaa aggaggcctt caatcgtgcc ttcctcccaa ttgatttggt gcgcgccaaa 1051801 aacgaagcag tagcccccgg cttgctcgtg taacgtgaca agtttagaaa aaaagaggga 1051861 acgatcctta aatgggcgtt caagagatac agtaaaccct gccgtaaaga tgccgactaa 1051921 cggcccgata tgcactgtat gatcatgaat cagtatatct gccctgcttc ggtggggaag 1051981 caaaagctca tgaaacagat tttcagagag aagcacggtt tgttccagat gccgtctgta 1052041 agcaacgtgg catctgacaa ccttcgttcc gaatgcggca tgcaaaagtc cgtcttgctt 1052101 cagcgaagag ggcagaaaca gggtgttttc actggttttg tctatgccga tcaaaaaccg 1052161 tttaggattc acgcggaaga actcctttct ggctttgctc agaaaacaga tattggcagc 1052221 gttttagggg acaagtgtac agctgttctt tttgctcggg agagacacgc aggattgact 1052281 tcctgcctgg tttggaattg atatctaaaa tccaaattct cccgtccttt gcaagacata 1052341 tatcaagacc gagttcaaac aacggcccat agcgctcgtc aagataatac ggaaccgatt 1052401 gggtaattga aaacacatca tctagtaaaa ccacttgctg ttttttcggt atatcttcaa 1052461 accaggagtc aaatgtcagc gcatcagatc cgcctgacaa attggccagc agcccgtgtt 1052521 tgtatccgcg tcttactgcc tttccgactg tattccattc acctgcttcg tttttttcca 1052581 taaacagacg aatatcacaa gggtattgtt ccttatcttg aatgtttaag taaggctgaa 1052641 gcaaatattg atgctgaagc acttttttgc accatgtttt aaaagaagtc tggttggaaa 1052701 acgtttttgt ctgcttatcc tttccgatgt gataagtagc agtgatgttt ttcttgccca 1052761 gcttcaaaag aatcacgcct ctgcctcccg cgccgaatgc cggtttaagg atgcaggctt 1052821 tttctttgga taaaaaggag tgaatttgtt cgtagcggct cacctttatc gtttcgggaa 1052881 tatagggatt gattacagag tgctgctgca aatcgtgaag gacggtccac ttatcgggaa 1052941 gaccccgccc gataaattcc gttttcggat attttttgag ccactcaacg attggttttg 1053001 ctttttggga atgtgaatcc ttgccgtaaa aacagcgatc ataaatataa tctggaatcg 1053061 ccatttcagt ttcgttccat gtgctgctgg ccgaatgata gaccgatgct ttgacacgca 1053121 aagtgtcagg tgaaatatca aatggtgtaa accggatgaa acgtatgccg aattcgggtg 1053181 ctcttttggc cagttctgcg gaataatccg cttcatgctg gcgggataag gacataaaac 1053241 cgagtgttat catggtgaga ctcccccttt tattcaaaag ctgccggcgg gtgtccgcag 1053301 ctttacacta aatacatgta agacgaacgc agctgacggt attctacttt acagaatacg 1053361 attctccacc ttgccctatt ccaaaagaac aagctgattt tctaagaaca ggaatttgtc 1053421 tcctcgtttg ctaagtgatt gcatgagcct ctataatacg tataggtaca taatctatat 1053481 gaaaaaagct gaagcacaga tggaggaaga tgaataggaa tgggtattgc aggaaccttt 1053541 atttttatga tcgtgatcgg cgctgccatt ggagcggtga ccaatcattt agcaattcaa 1053601 atgctgttta ggccgtataa agcgtactat ttgtttggga aacgagttcc ttttacgccc 1053661 gggctgattc caagacggcg agatgaactt gcaaaacaaa tgggactgat ggtagtcaat 1053721 catctcttaa cccctgaagg cattaaaaag cggctcgtct ctgatgcagc caaaacgcag 1053781 gctcttcgag tgggggaaca gctgattcaa aagctgtcac tttctgaagt gacagtaaaa 1053841 gaagcgcttg aaaaagccgg gatgaagcgc cccgaaaaag ctgctgatgc atggatcagc 1053901 agctggaccg atgataagct gcatgagctt ttccgccaat acggggacca atcgttaaaa 1053961 gagctggtgc ctatagaggt gcaggaaaag cttgaggaaa aaattccgat gatttcagga 1054021 tatatattgt cacggagtgt ccgttatttt gaaagtgatg aaggaaaaat ccgtcttggc 1054081 aatatgattg atgacttttt aaaagagcgc ggcatgcttg gaagcatggt gcaattgttt 1054141 cttggcaatt caagccttgc ggatcgcgtg ctgccggagc tgctgaaatt cttgcgcaat 1054201 gaggaaacaa ataaattgct ttctgatctc ttaaaaaacg aatggggcaa gctgagggag 1054261 tatacgttta atgaagcaga tgaaaaatgg aatgcaaagg cgctcatttt cagtttgaaa 1054321 cgaagagtgc tgcaagcatt ttcgactgcc cctttcttca acaatacgat tggcacgctt 1054381 accgtccgct atgaatctga gctgacccag caaatgctgc cggcactatt agacaaattg 1054441 cttgaaggta tttcgtccaa ccttgaaagt gtcttaaaac ggttgcgtct tgaggaaatc 1054501 gtcaaggagc aggtggatca gttcccggtg gagcgtcttg aagaaatggt gctgtccatt 1054561 tcaaaaaaag aatttaaaat gattacctat ttggggggcc ttctcggcgg aattataggc 1054621 gcgattcaag cattgtttgt catccttttt taagaagaaa tggtttttga ttaatgaaag 1054681 gagctccata gtctgttata gtggagtggt atgtcaaacg gcaatgatga aaggagctat 1054741 ttacaatggc tgttaatttt tatgatgtag cgtatgatct ggaaaatgca ttacgcggga 1054801 gcgaagaatt cacccgttta aaaaaccttt acgacgaagt taacgcagat gaatcagcga 1054861 agcgcatgtt cgaaaacttc cgtgatgtac agcttagact ccagcaaaaa caaatggcag 1054921 gagaagagat tacacaagaa gaagtgacgc aggctcaaaa aacagttgcg cttgtacagc 1054981 agcacgaaaa aatttctcag ctgatggaag cggagcagcg catgagcatg ctgattggtg 1055041 aattgaacaa aatcattatg aagcctttag aagagcttta cggcagtgtt gaaggctaat 1055101 aagcaaaatc ccttcttgga taagaaggga ttttttattc actcagcaaa cttggaaatc 1055161 caatgaatct tttacctctc cattgatgat gactgataat gtatgaattc ctttgtaatg 1055221 ctttctggtg gttaaatcct taaaggattg gattcttgtg tatgacttcg tttcgttttt 1055281 tcgtatattt gtttctgtta ttttaaatac tttctgatga cgctggcctc ttgcttttac 1055341 aaaatcaatt gcgtactcaa ttcttacttt ttgatccctg tctgaatgaa tatagaaaga 1055401 aaattcaagg ctttcgccaa taactatacg tttgggctgg catgttaaat catgtagttg 1055461 tatcgaatca gcattttcat aaccaaaaag cgctaaggcc tgtttatcac ccttttttaa 1055521 taaggtccga taggcgtgtt tgataatcca gtctgtatgg ggatgtgttc cgtaccattg 1055581 atctgcgact tttctcagta aatgaggatg cgtttttgat atatcattaa ggttgttggc 1055641 cacgcttttt cttacatata aagactcgtc ctgcatcagc ttctcaagga tcggcaatac 1055701 gggggaaggg tccgatttca aagccggtat cgattttccc catggcaggc ggggcctgct 1055761 gccttcgctc gcaagtcttc tcacgtgttc atttttatgc tcagaccatg caagcaattg 1055821 tgcaatcatc ttttcttgat ctaacagcaa aaaaggcctt acagcaaatt ctgaggtcga 1055881 atattgcgta aaggattcca atgcctttat tgattcttcc caatgcgcta acccgtactg 1055941 ttccacataa tctggaaata aaattccgct gagtccttta aaatgagggg ctgtatcccg 1056001 taaaattgtg agcgcttcaa cgtattgttt tggcaaagtt tcgtataaag aaactgtcac 1056061 gcggcgcatc cgctctttta aagtgagttc aggccagtcc tccagccgta atgtatccaa 1056121 gaatctgttt ttgttaaaat caggatagga tgaccttaca tgatggatca actgagatat 1056181 cagttcttca ttatatattt cttttaaatc agccatataa acaccgcttt ttcgtttatt 1056241 atttatattg tatgggaatg tacgttctgg atcaagtgta tagtcctaaa aattaacaac 1056301 tgatcctacc acggatatac aaaagttggt tacttttttt agttaaaaaa acccttgtca 1056361 tcggaaagga aaactgagat aataacattg aaagcgccta cacttaccta tttcaaatgg 1056421 atacggtcgc atatcatgcc gttatataga ggggataagc aacagagagt aagtgttcgg 1056481 agcgcatcat tggtcaaaca aggggttcct gatacatgat ttttcgtaaa tcgaaataac 1056541 gatattaggg agaatggctg cttcgatcgt atcctatcaa caagccatac ataaagtctg 1056601 ctgagccagg ctttttttgc tttaagaaaa ggttgttcta aacacagaga cagggtcata 1056661 tcctatacac aagtacagtc atcaaggagg gggacatctc tgtgtcaaaa caattgcttg 1056721 ccttaaatat agatggagcg ctgcttcggt cgaacgggaa gattcatcag gcaacgaaag 1056781 acgcgattga atatgtaaag aaaaaaggga tttacgtcac acttgtgacc aaccgtcatt 1056841 ttcgctcagc acagaaaata gcgaaatcgc taaagcttga tgccaagctg atcacccata 1056901 gcggggcata tatcgctgag aaaattgacg ccccgttttt tgaaaaaaga atttctgatg 1056961 atcatacctt taacattgtt caagtgctgg agagctatca atgcaatatt cggcttcttc 1057021 acgaaaagta ttccatcgga aacaagaaaa aggtgaattc gaatttatta gggaaagcac 1057081 tcattcatcc gtctgacccg atcttttatc cagtccagtt cgttgaatca ttaagcgatc 1057141 tcctcatgga tgagccggtg agtgcacccg tcatcgaggt gtacacggag cacgacattc 1057201 agcatgacat tacagaaacg attacaaaag ccttccctgc ggtggacgtg attcgcgtaa 1057261 acgatgagaa actgaatatc gtcccgaagg gtgtctcgaa ggaagcgggt ttggccctcg 1057321 tcgcttcaga gctgggcctg agtatggatg atgtcgtggc cattgggcat cagtatgacg 1057381 atctgccgat gatcgaactt gccggtcttg gggtagcgat ggggaatgcc gttccggaaa 1057441 ttaagagaaa ggcagattgg gttacaaggt ccaatgacga gcaaggtgtc gcttatatga 1057501 tgaaggaata tttccgaatg cagcagcgaa aaggatttct tgataagttc cacatgaaac 1057561 gtgtgtaaaa aagccgctcg cgccctgaca ggtgcggcgg cttttttgcc ggattgattt 1057621 tagcagttta tttctgtaca ctaaagaaag ttttgaatct gataaattag gtgatgaagt 1057681 tgcaaattaa aatagaaggc atacatgatg accgcctgca tcggcctctg caaaatattg 1057741 caaatttgtt ttatgaagag tgcgagcttg cgtatggcgg agaggagccc gcagattttg 1057801 tcatttcttt agcgttgtca caaacggatg agcatgtgac ggtttctgga gaagtgaagg 1057861 gtactggcat aaaggaacag catacaaaat tcttttctcc agacatgact gaaaaagaag 1057921 cttttaagca agtgaaaaac acaatttctt atgtgtatct caatcttctt caggcgcata 1057981 cgggcattac gcagaagtgg ggaatcctca caggaatccg gcccacaaag ctgcttcata 1058041 aaaaactgca aagcggaatg tccaaggagc aagcgcatgc tgagttgaaa aaagactatt 1058101 taattcatga tgaaaaaatc atgctaatgc aggaaattgt tgaccgtcag ctggcggcag 1058161 tgccggattt gtaccgagta aaggatgaag tcagcattta tatcggcatt ccgttctgcc 1058221 cgacaaaatg cgcgtattgc acattccctg cgtacgctat ccaaggacag gcgggcagag 1058281 tcggctcatt cctatgggga ctgcattacg aaatgcagaa aatcggtgaa tggctgaagg 1058341 agcatgatgt taaggttaca accatttact ttggcggcgg gacgccgaca agcattacag 1058401 cggaggagat ggatctgctg tatgaagaaa tggtccgctc cttcccggat gtgaaaaaca 1058461 ttcgtgagat tacggtggag gccggtcgtc ctgacacgat tacagaagaa aaactcgccg 1058521 ttttaaacaa atatgacatt gatcggatca gcatcaatcc gcaatcctac gaaaacgaaa 1058581 cgctaaaggc gatcgggcgg caccatacgg ttgaagagac cattgagaaa tatcatctgt 1058641 cacgccagca cggcatgaat aatattaaca tggacttgat tattggtttg cctggggaag 1058701 gcgtgaagga gttcaggcac agtctttcag aaacagaaaa actgatgccg gaatccctta 1058761 ccgttcatac tctttcattt aaacgggcgt cagaaatgac gagaaacaag cataagtaca 1058821 aagttgccgg cagggaagag gtttctcaaa tgatggaaga cgcggtagcc tggacgaaag 1058881 agcatgggta cgtgccttat tatttatacc gccagaaaaa cattcttgga aaccttgaaa 1058941 acgtcggata ctctttgccg ggacaagaaa gcatctacaa cattatgatt atggaagagg 1059001 tgcagacgat tattggcatc ggctgcggcg ctgctagtaa atttattgat cgggatacag 1059061 ggaaaattac gcattttgcg aatccgaaag atccgaaatc gtacaatgag cgcttcgagc 1059121 actacacgga cgaaaaaatc aaatatttag agcagatttt tgaaaaaacg acaaagcagc 1059181 actgattaca gtgctgcttt ttttatccct gtttttttgc gggctgaacc tcaggcttcc 1059241 atttaaatac cttgttcagc aagcggtaaa ttcgttttga ttcctttgtg acaagcggtc 1059301 ccaaaatcgc cagaatgagg acatataatg cggcaaacgg ctttaatgtg gccgacagtc 1059361 cgccggctat cccgagattc gcaacgataa tcgaaaattc tccccgcgat acgatcgtca 1059421 gcccgatatt cgatgaagcc ttatgagaaa gccctgcgcg tcgtcctgcc accattccgg 1059481 cgataaaatt tcccagaatg gtcaaaatca ctgcacccaa cgcaagccaa accgcttcac 1059541 caagcgaaaa cggatcgatg ctgaggccga agctgaaaaa gaacatcgca ccgaagaagt 1059601 cgcgaaacgg aacaacgagg tgttcaatcc tatcggaatg ctctgtttct gaaaagacca 1059661 aaccgagcag cagcgcgccg attgcttctg ctacatgaat cgtctctgaa aaaccggcga 1059721 taaaaaagag tgctgcgaaa atgacgataa taaacacttc gtttgagcga atgtccaaca 1059781 gtttgttcaa cagcggcggg agttttcttg ctgcgataaa aaacagcagc atataaccga 1059841 aggcgatcaa aatggacaag agtgcactcc ctacggatgt cgcatcacct agtataaggc 1059901 cggaaacaac ggacagatat acggcaagga aaatatcttc aaacatgatg atgccgagaa 1059961 tcaattcggt ttccgggttg gcggttcttt ttaaatcaac gagcactttt gcgacaatcg 1060021 cacttgacga gattgtgatg acgcctgcga ggatgaggac ttccagaaag gaaaatccgg 1060081 tgataaaccc gtaaagcagt ccgaggctga agttaatcaa aatataaatc gtcccgccga 1060141 ccgcgattga ttttcctgat ttgattaact tcccgacaga gaattcgagt ccgagataga 1060201 agaggaggaa cagtacgccc attcgcccga aaaactcgat gatttcactg ctttgaataa 1060261 atgttagatc aataatcccc attttcggcg cgtgcggtcc aacaagcatt cccagcacaa 1060321 tcagaaacgg aataatcgaa aatttaattt tattggcgat cacactggcg attgccacaa 1060381 gcacaagtgc agttccgact tcaaatacaa gatggtccat cggggctcac acgccctctc 1060441 cagaaagaaa atcgtgaatc agtttcttca gatgctttct ctcacctgag aggacaaggg 1060501 tgtcattttc ttcaataatc gaatccgctc cgggatttag gagcttttcc tggttgtgtt 1060561 tgataatcgc aataacagtg acatcgtaat tctggcgaac atcaagctca ccgagtgtgc 1060621 gtccgatcga tttggcgcct ttttcgacct taaaccattc aataataaga tcgctgaagg 1060681 ccatttcgat ggactccaga gcttgcggtt tatagaccat gcccccgaga atagctgcaa 1060741 tttgccttgc ttcagaatca tccaatgaaa tatttgaaag aagctcatcc gggtcccggt 1060801 cattaaaccg gtaaatttcc cttcttccgt catcatgaat gataatcgtc attttttcgt 1060861 ggcttcttgt ttcgatttca aactttttgc cgatgcccgg cagatcgttt tctttaatat 1060921 tcaatgaaaa tccctccgaa tgtagtgttg gcagtatggg gtgagttaca aataaaactt 1060981 gagcaaatta tattcggagg taattagact ggtatttgac agggacggcc aaagcctttt 1061041 ccagcctgtt tatcagcggt tcgtcaagtg gtttgacaga gagctgcctg acagactgcg 1061101 ccagcgggct gtactctttg atcagctcag ccgggtgcat gctgcccggc gatggcgttt 1061161 ttgccgattg tgtttcctgc ggatatgaag acataggcac atagctgtca gtgcttgctt 1061221 caaactggga aggcagaacc acgtccgaag ggggaaagta caccataaat aaacttaaca 1061281 gaaaactgat cagcaattta tccatgttcc tttcctccct tctcatcaag atatcccttc 1061341 tttttcacta tataaaactt tatgtttcca ttcaaacaat atgcattttt cagtatctat 1061401 tgaccttgaa aaataaaaag gtttatttgg ggatggcggg gaatgtatag gagaaagaaa 1061461 aaagtaagcg catacatgga ggtgctttta atggagtttg ttcaatatgc atgtaatggg 1061521 gccgttgcag agattatcct gaatcggcct gatgcccatc acgccctgaa tgaacagatg 1061581 ctgtctgaat tgaaggaggc agtcgaaatg gcggctgcaa gcgaggcgct catcgttctc 1061641 ctgagaggaa gcgggaaagg cttttcggcc ggcggtgata tcaggatgat gacgtcagag 1061701 catgaccctg accaatttaa acggctgatg gatacgattg aggctgtcac cctgaattta 1061761 tatcagatga agaaagtgac aattgcagcc attcatggtg ctgctgcggg actgggcctg 1061821 agtttggcgc tttgtgcgga cattgtgctc gctgaaaaaa acgccgttct cgcgatgaat 1061881 tttatcggca ttgggcttgt tccggacggc ggaggacatt atttgctgaa gaaaagaatc 1061941 ggtgaagcaa aagcgaaaaa actgatttgg agcggaaaaa aactatctgc ctcggaagct 1062001 gccgatatgg ggcttcttga tgggacattt gccggagacc ctgccgaagg cgcaagaccc 1062061 attatcgaaa ccctgttggc ctcccctctt ttggcgatga tcgaaacgaa aggtattttt 1062121 caaagcctcc aaattgaaga actgaaaaaa gtgctatccc ttgagcgcag cgcccaagag 1062181 agaatgagaa ggaccaagga tcaccaagaa ggaatccgtg cctttttaga aaaacgggag 1062241 ccgaagtttc aagcgtaaca gatcagccgg aaagctgatc atctgtgaaa caaaatcagc 1062301 tttccggctg cattgactaa acgatgagta tgactatgaa gctctttttc ttttaagagg 1062361 gcttcaccat gcgtttttgc cgcttcttca tgttctgcct cgaattgctc gtttaccagc 1062421 gtgttccccg aaggatcaaa tacggtaagg aaataatcag ccatcaggtt tctcctccat 1062481 tttaaggttt atcagtcttt cttcatttat attctaaaaa ggaaatcaaa atcctttatt 1062541 atgctttatc caaaattagt atataatggg tcagggaagg aggagattca gtgcttacaa 1062601 ttgatcacgt aacgaagaca tttggagatt ataaagccgt tgacggattg gacttagata 1062661 ttccggaaca gcaaatgttc ggtctattag gcgcaaacgg agcgggaaaa acaacaacgt 1062721 ttcgcatgat cctaggatta ttaagcatta cggagggctc aatcagctgg aagggccgtc 1062781 ctgtgaatta tcatatcagc aacaaaatcg gttatttgcc ggaagagcgg ggcctttatc 1062841 cgaaaatgaa ggtaagggat cagctcgtct atcttgccag attaaaaggg atggagaagc 1062901 gagaggctgt aaaagagctc gggacatggc ttgaacgctt caatattaca gattacgaga 1062961 ataagaaggt ggaagagctt tcgaagggga atcagcagaa aatccaattc atttcggcag 1063021 ttttgcataa gccggagctc ctgattcttg atgaaccatt cagcggcttg gaccctgtca 1063081 atgttgagct gctaaaagag gccgtgatct cgctgaaaaa cagcggtgtt tctattttat 1063141 tttcaagcca tcggatggaa catgtggagg agctttgtga gaacctttgc atattgcaga 1063201 aaggaaaacc ggttgtacaa ggcaagctga aggagatcaa gcgttctttc ggtaaaaaga 1063261 atgttaccat tcactccgat gacgatctgc gctttttgca gtcccatgaa ggcattcttc 1063321 aatggaagga aacggcagac ggcgtcaagc tgcagattgc caatgaagac atttctcaag 1063381 agatttttgc gatgctccaa ggaaaagggt ttatcagaaa gtttgagctt gaagagccgt 1063441 cactgcatga tatttttata gaaaaggtgg gggccgtcta tgaataaatt ttggatcatg 1063501 ctttctcata catacaaaaa taagattatg gcaaaatcct ttattatttc gactgtcatc 1063561 acggtgctgc ttgttttagt tgtaacgaat ctggagtcga tcatttcttt gtttcaaggt 1063621 gacgatgcga aagaaaaaat cgccgttgtt gatgaaacaa acgaattata tccggttttt 1063681 tctaagcagc tgaaagcggt ggatacagac ggcgatcttg atgtgaagct gtcgaagcaa 1063741 tcggaggatg aggtcacaaa gcaagtcaaa gatgaatcac tcgatggcat gctcatcatc 1063801 aaacgagatg aaaaagggac catttcagga acatataaag cgttaacgat ttctgatgaa 1063861 agcacgtatc aaacactgca gcaggcgctg acgcaaacca aaacagctgt cggaacagcg 1063921 gagctcggcg tgtcgcagga aacgattagc agcctttatg cgcctgttac tgtggggcag 1063981 aaggcgctga aagaaggggc aaagtctgag gaagagcttg gccagacggt agggcttgtt 1064041 tacattatgc tgttcgtcat ttatttctcg gtgattatgt atgccagcat gatagcgatg 1064101 gaggtcgcaa ccgaaaaatc ttcgcgagtt atggaaatcc tgatctcaag tatgccgccg 1064161 atccagcaaa tgtttgcaaa gctgcttggt atcgggcttg tcgggatcac acagcttgct 1064221 attattatag gagccggctc tctgtcgctt aagctgaacc aaaagagcga aacggcttca 1064281 tctgtcggcg gattccttaa tttgaccgac gtatctgcaa ccactgtcat ctatgctgtc 1064341 attttctttt tgctcggata ctttttgtac gcgacacttg ccgcgtttct cggcagtgtc 1064401 gtcagcagaa tagaggacgt gcagcaaacg atcacgccga tgacgctttt ggttgtcgcc 1064461 ggttttatga tcgcgatgtt cggtttgaat gcgcctgacg caggatttat tacggtaact 1064521 tcgtttattc cgttctttac gccaatgatt atgttcctgc gcgtcggcat gcttgatatt 1064581 ccgttctggc aggcggctgt cggaatcgga atcacactgc tcaccattgt catactggcc 1064641 gttatcggcg ccagaattta taaaggcggt gtattaattt acggcaattc aagcgcgttc 1064701 aaagcgatca aacaagcgct acgtttagcg aaaaactgat tggaaaacag cctggggatt 1064761 ctcaggctgt ttctttattg acagaacgtg cattcgcaag aattcggtgc taaaataagg 1064821 gtacttcatc ctggaaagga gcagaatgtt gactgatcta acctttattc atgcggcaga 1064881 tcttcatctt gacagcccgt tttacgggat atcgcatctg ccggagccga tttttgcccg 1064941 gattaaagaa agcacgtttg caagcgtgag acatatgata gacgccgcag tgagagagca 1065001 cgttgatttc attttgcttg cgggagatct gtttgatgaa gccaatcgaa gcttaaaggc 1065061 tcagctcttt ttgaaaaaac agtttgaaag actcagagag tgcggaattt cggtatacgt 1065121 catctttggg aatcacgatc atcttggcgg ggagtggacg ccgattgaat ggcctgagaa 1065181 tgtccatatt ttttcgtccg ctgttccaga agaaaaatcg ttttttaaag aaggcaggcg 1065241 catagcaagc atttacggct tcagctatca agccagagca ttgatggaaa accaagccgc 1065301 ccgctatcgg agatcaactg acgcaccgtt tcatatcggc atgctccacg gcacgctgtc 1065361 aggatctgaa ggacacgatc cgtattgccc gtttacacat gacgacctcg tgaaaagcgg 1065421 gatggattat tgggcgcttg gccatataca taaacgccag gttctatctg ccgagcatcc 1065481 ggcagtcatt tacccgggaa acacgcaagc acgccatata aaggagacgg gagataaagg 1065541 ctattatctc gttcatgtga caaacggaga tatatcttat gaatttcaga gagcgcatga 1065601 tgtcctgtgg gaaaaagcgg cggttgatgt gacggaggca aagaatatga cagccctctt 1065661 ccaaatggtg gaggacacgt tttcgaagct gcggaaaaag gggagccctg tttgtgtaag 1065721 gcttgtttta caagggacgg cgccggaatg gctgctggag gcgccaaaag gcaccttgga 1065781 tgagtttctt gaagctcttc aggaacaaga agcggaagag gaacgtttcg tttggcctct 1065841 tagattggac gatgagacag aaaacgaagc aaacctaaca aaccttgatc ctttttttgg 1065901 cggtttattt gaagacattg atcgcagcga tctgtcagac gtgctggaag ggcttgagcg 1065961 gcatccagtg tatagaaggc acgcggaccg gtttagccaa gaggaggtaa aggaaataaa 1066021 agagcaggca cagataatat tgaaaagaca gcttaaggtg cttgatacat gaggcggtga 1066081 cagctttgcg aattatatct ttacatatct accaatacgg aaaattttcc aatcggacct 1066141 ttgacttttc cgcctctcct gtccaagtca tctacggatt aaatgaggca ggaaaaacga 1066201 cgatgatgtc attcattgaa agcatgctgt tcggttttcc gaaaacgaaa aagtatgaac 1066261 cgaaaacagg cggtgtctac ggcggtgttc ttgaagctga acatcctgag tatggggtgc 1066321 tgaagatcga acggacgaaa gggactgccg aaaaactaag cgtgtacaca gaaaagggcg 1066381 aagtaaagca gggagatgtt ttaaagcagc tgttccaggg cacagacagg tcgttgtaca 1066441 aagccatata ttcgttcgac gtattcgggc tgcaggaaat tcacgccttt aatcgggaca 1066501 agatagggga atttttgctc ttttccagct tgtttggtgc tgaagccgta tcaaagcttg 1066561 attcaaggct gacgaaggaa agcgaaaggc tctataaacc aaatgggcga aaccctcaat 1066621 tgaatcagga gctggaaacg cttaagcagc tggcagttaa gctaaaacag gctgaagcag 1066681 aggaagcggg ctatcatcag cttctcgagg aaaaacgaac gcttgaagcc cgccttgcag 1066741 ccgcggaaac cgaattgaaa gagacggcgg gacatatccg aatgattgag ggagcgattg 1066801 agcgaaagcc gctgctaaat gaaaaagcga cactcgaaca ggtgattgca gaatttccgg 1066861 aacacgcagg acaatttcct gctgacggac tgcatcagct ggaaaaatat gaatcccatc 1066921 ttcacccgaa atcagcacag cttgaggcgc ttcgggtgaa gatggcggag ttggacaaac 1066981 agaggcaaaa gcttatcccc gataaagaac tattggcgaa agaaacgctg atacaagagc 1067041 tttcggcagc gtttcatatg taccaatcct ggggagaaca gctggcagcc attcaggcac 1067101 agctgcgcca gacgtctgcg cagacagcgg cagggctgga acagctcaat aaaacggatg 1067161 aaaatgagct cctgaatatg aacacctcat atgattatga atggcagctt cagcaagcgg 1067221 tgcagcaata tgtacaggca agagacagaa aacggcagct tgacgagacg tttgaacttg 1067281 cccggcaaga gctggaagac gcggaaaagg ccgttcgtgc cgcttcgtcc gcgattcttg 1067341 aaaacagcca aagaaaagat aaagaagcag ctcttagagc atatgatgaa acacaggggc 1067401 agcaccaaga gcaagcgaag ctcagagaac agctaacgtt ttttgaaaga cagcaggcta 1067461 aacagaaaaa gactgtcatt gcagctggta tgttgttcat cgttctcttt tctctgctgc 1067521 agcaatggat tcccgccata agtttcggcg ctgcacttat tgtgtattgg cttgtttcag 1067581 gaaagtcgtc ttctcgaaac agccgagaga caagacagcc catgacggat atttcaccag 1067641 cagaagctga aatgcttaga gaagcgttat gggaggatga ccgcaataag cagcaccttc 1067701 tcacacagcg tgcagcgctc cagcaaaaag aggcggcgta tgaaagggtc atccagcagt 1067761 ttgaacagtg ggaagccgaa atggcgccgt cctttacaca ggttgagcgt tttatgaatg 1067821 agctcggatt taaggaagat ccatcatttt tgcttgatgc atacagctta atgaaggatg 1067881 ttaaaaaaga agtgaagaaa aagcatgagc tgaccataga agcaggcagg ctgaaaaagc 1067941 accggagaac attcgaagaa cgcgtcagta tgcttcttcc cgtgaatcag agtcaggata 1068001 tctccatttc ggacgccctt cacacattgc ggaaaaacat tgaacgtgaa aaagaaattg 1068061 agaagcaaaa aaaggaaatt gaaacagata ttcattatac aaaggaacag atgcttgaac 1068121 ttgagcaaga aatacagtat ttccacgcac agattgaaca gttatttgcc gcggctgctg 1068181 caaaagacag agatgcgttt tttgccatag ccgccatcag caggcaattg aaggatacgg 1068241 agaacaagct tcatcacgta aacgcacagc ttcaaggcgg gtacccggag gaacttgaac 1068301 tggcggattc caatacgctt tctgaattga aagataagca atttgttgag aatgaaagaa 1068361 aagagcggct gactgaggag atcgagcagc tccgcagcca aatcgcactg ctctcagtca 1068421 aacaggaaca attagaggct tcgggaatgg tctcagacct caagcttcaa accgaaatgc 1068481 aaaaagaacg tgtgaaagaa acggctaaaa aatgggcctc catacaaatg gtcaaacagg 1068541 tgatcagaaa caaattggag cggcataaaa aaatcgagct tccgcgcctt ctggagacgg 1068601 caggagaatt tttccgtcct ctgactgacg gaaactacca aaccatttat ttttccgaaa 1068661 cggatgattc gatcatggtt atgcatcgcg atggcactgt ctatcatgcg gaagagctgt 1068721 cacaagggac gtgtgaacag ctgtatacag cgatccgctt tgctttggcc gttacgcgcc 1068781 agggtgagtc aaagcttccg ttccagcttg acgacagttt tgttcatttt gatcaggaaa 1068841 ggctgaaacg tgtattacat gttctgtatg atttatctga aggcggtagg cagattttgt 1068901 attttacatg ccatgagcac gtaaaagatg catttcatag cagccaaatc atccatttgg 1068961 tgtcataaaa gaggttctat agctgaaaat cggtatgtga tatactggta ttatgtaaga 1069021 tacggaggga gctttaatag aatggctaaa gggattatgc tacatgaggt tggcgaacag 1069081 gtggaccagt atctattgat taaatcctcg acgaaaggga ttgcaagcaa tggaaaaccg 1069141 tttctgacgc tgatgctgca agaccagtca ggcgatattg aagcgaagct gtgggatgcc 1069201 aagcaaagtg atgaagtgac ctatgcgccg cagacgattg tcaaggtcgt cggcgatgtt 1069261 caccattatc gcggacgcac ccagctgaag ctaagaaata tcagaccggt aagcgagcaa 1069321 gaaaacgtca atattgatga ttttttagaa accgcgccga ttccgaaaaa tgaaatgatg 1069381 gataccatca ctcaatatat atttgaaatg aaaaatccga atatccagcg aatcacaagg 1069441 tttttggtta aaaaacacga agctgagttt atggattatc cggcggctac gaaaaaccac 1069501 catgagtttg tctcaggttt ggcgtatcat gttgtctcta tgctgaacct ggcgaaagca 1069561 atagcagatt tatatccttc tcttgatcgt gatctgcttt acgccggtgt tatcctgcat 1069621 gatcttggaa aagtgaagga gctgtccggc cctgtttcca cttcatatac ggttgaaggc 1069681 aatttgctcg gccatatttc catcatggtg acagagcttt caaaagcggc tgaggagctt 1069741 caaatcgatt ctgaagaggt gttaattctt cagcatttga ttttgagtca ccacggcaaa 1069801 gcagaatggg gcagcccgaa accgcctatg gtgaaagaag cggaaattct tcactatata 1069861 gacaatctgg atgcaaaaat gaatatgatg gacagagcgc ttgagcgcgt gaagccgggc 1069921 gagtatactg aacgtgtatt tgcactggaa aaccgttcct tttataaacc gacatttcat 1069981 aaataactta aaaaggactg atgctgacat attcagctca gtcctttttg atgcgtcttt 1070041 cccgcacata actcgtctca ttcccgcata tggttaagaa taaagaatct atgcaaaggg 1070101 ggaggagccc gtgttatttt ttccgtggtg ggtgtatctt tgtattgtag gcatcatttt 1070161 cagcgcatat aaacttgtgg cggcagccaa agaggaagaa aaagtagacc aggcttttat 1070221 tgaaaaagaa ggacagattt atatggagag gatggaaaag gagcgagaac gccgcagttc 1070281 tcagcagcat gaagaagaaa atcaaaacca ttccatcgca taaaaaaagc tgtgcggctc 1070341 aatgagccgc acagcttttt ttattattta gaattgcttg aagatgaaga agtgctgttg 1070401 cttgttgaag atgtattaaa tgtgtctttc agatctttat cttttacttc gatgtcagcc 1070461 ttcttcatga ctttttgaac agcttcctga acagctgcgt tgtcatttaa tttttgttca 1070521 agcacttcag atttcagttc ttttttcata tcatcatatt tgccgcgttc ttctgtcttt 1070581 ttaatgatat ggtagccgta ttgcgttttg acaggatcac tgacttcacc tgtttttaat 1070641 ttgaatgcag ctttgctgaa tgtttcgtcc atttggcctt cttttgcgaa ccagccaaga 1070701 tccccgcctt ttgaagcaga gctgtctgtt gagtattctt tcgcaaggtc ttcaaacttc 1070761 tcgccttttt tcagcttttt ctctacttct tcagctgtct ttttatcagc aacaaggatg 1070821 tggcttgcac ggattttgcc ttttaagcct tcccagtact ctttgatatc ggcgtctgtt 1070881 actttgatgt tatctttagc cgctttttgt gtcagcaatt catattttac ttgttctttc 1070941 aggtaatctt tgccatattg cttttcgagg gcagtatatt gatcgccaag ctgcgttttg 1071001 tattctttca gcttgttgtc aatttcttta tccgaaactt tatacttctt gtccaatact 1071061 ttttcttgca ctagctgtgt cagtacgctt gcgccagctg ttttcttcat gtttgtgtaa 1071121 agctcgcctt ttgtgacatc gcctgcgtct gtttttgcga taacttcttt gtcgccgctg 1071181 ctgcaagcac tgagagcgag gatgcttgta gcagtgatag ctgctattgc gattttcttc 1071241 attgttttca aacactccta atcattccaa attaaattac ctatgcgtat cataacatat 1071301 tgtggctttc tgtaaaaaga ttttaaataa agggcattcg tctagtcaaa cttttgctga 1071361 tgacatactt atatattgat caagaaaagg aggtatgtaa catgagcgga ggatactcta 1071421 acggattcgc gttgctcgta gtactgttca ttttgcttat catcgtaggt gcagcttaca 1071481 tctactaagc agcccgagga tcgcttgcaa cataagcgat cctttatttt cactagcgcc 1071541 taatcgtttc aaacatgaat tgcataacat gtaattggta aataaagctt attacaggag 1071601 gtgctattta agatgggtga agtatttgca ggcggattcg ctttattggt tgtgttattt 1071661 attttattga ttatcatcgg cgcttcttgg ctgtactaat caacataaaa aagcatagct 1071721 gcttaatcag cagctatgct ttctttcgta tttacactgt aaaggagatc tccacaaacg 1071781 aagagatcag taaaattaat atagatacat taataaatcg gaatacctta tcttgccgct 1071841 cttcaggaat ctctctgaca aggcataatg tattggtgag cctgtttatg aaatataaaa 1071901 taaacacggc agccacgata aaatagaata aaatgatggg agattccccc tctctctgaa 1071961 ctgtcccata ttacattacc aaatatttat taaaaaagat agaatgcaaa ttgaaaaatc 1072021 gccaccagca ccagggtttg actacttttc aacaagaata tccaagccgt cagcttcctg 1072081 atcaataaaa gcggttttcg gtgcttttat cagcttgaga gccagcagga aatcaggcag 1072141 acagtagccg gcgtgaatgc ccgagatcat gcaaaaataa tgagcgtgat tcggaaatgc 1072201 cagtgctgcg taaaacaata ccggtgtaat cagcaagaac gggctgacga gtgaaatcag 1072261 cattgttgtt tttggtatac gtttccatgt gcgcatgcgc aatatgtaaa actttttttc 1072321 tatttttctt tttttgcaga tgattggcag gacatggatg actttatgta caaataaaat 1072381 aacgacgagc aaaccgccga ataaagatac atattcatcg cttaagcttg tgccaggccg 1072441 cagcagctca aaagctaaaa aggtagatat aaaaaccaaa atcataaaac atacagcagt 1072501 taatattatg cgaacggcgc cataatcctt catgagattt atggtcttcc agcaattcat 1072561 caaagtcatc cttccataca tcttgaatag aatctcaaaa taatttactc ctcccaagag 1072621 aaaaaatcaa tgctttttta agaaaaaata tcatccggca ggtatttttt tgaaacaagc 1072681 aaacaaactg cgaaatatgg ggttagaact ttcttctcag tgaattatca gctaaaataa 1072741 gattaaagat agaaagaagt ggtgtggatg gattcgatgg atcatcgcat tgagcgatta 1072801 gaatattaca tacaattatt agtgaaaaca gtagatatgg acaggtaccc cttctatgcg 1072861 cttctcattg ataaagggct gagcaaggaa gaaggggaag cggttatgag gatatgcgac 1072921 gaattgtcgg aagagctggc aacacaaaaa gcgcaaggat ttgtaacctt tgataagctc 1072981 cttgcgcttt ttgccggaca gctgaatgaa aaattagatg ttcatgaaac aatttttgcc 1073041 ctgtatgagc aggggcttta tcaagagctg atggaagtct ttatcgacat catgaagcat 1073101 tttgattaac tgtttacagg ttcgagctct tcagccggtt catccgccgc actgtccttt 1073161 gcttttttct tcaattttcc gtttacgctt tcaaagtcat tgtcaatatt ggtgagtgac 1073221 gtttcgaaaa tttccataaa atcatcgccg tagatatggc gtatcataca catcatttct 1073281 gccacttcag gaaattttcc gaataaatga tataaaggct gtgacccttt aaaaacagcg 1073341 ttgcgtgtcg gatcaaattc ctcaagcaag ctccagaata cctcggtacc ttcctcagtc 1073401 aattggacat atgtgttccg tttatcattc agccgtttgg agaaccttaa atatccccgt 1073461 tcttccagct tttttgaaaa gttgaatgcg gttgatacgt gcatgacccc gaatttcgcg 1073521 atttcagaaa tggaagctcc attcaattga tacgcaatcc ataaaatatg atgctcatta 1073581 atattcaggt catacggttt gagccattgc tgccaatcct tctcgatcga tttccaaaga 1073641 gccttgctaa gctgagccat tttctgggtg aaaaccagag cttctttcac atcatagggc 1073701 ggttccactc gattcattac gtcacctgct tctctttttc tttttctcta ttatgccaat 1073761 aaaataaaga ttaataaaga tgaaaatgta agaatttttt aataaattca caaaccattg 1073821 cgacgaaagg gtttttcggc caaaaaaaat acgggtccaa ttttggcccg catttttttc 1073881 ttttgaatag gatattagtt ttgtaaggtt ttctccagct gtctgatttt ctcttcgata 1073941 tcggcaattt ctttttgcag atcctgctgg tgaggcttga tctcttcctg ccatttttta 1074001 attgatgttt ggagctcgcc gcccacgtct ttaataacat ccgtgctttc ttttgccgct 1074061 ttgatcagct ggtcttttaa tgcaagcccg tctgacttta agcgtttgat tgtttcttca 1074121 aaagaatcat aattggtttt cattttttca cgcagctgct ttcctgagga aggtgcagta 1074181 agaagaaccg ctgctcctcc gatgatgccg cctacgaata gtcctgttaa tagagaacgt 1074241 ccgctcgcca ttacaatcac cccgtctttt tcttcaaaat aggattcatt cagcattttt 1074301 catttttgtt gaaagcctga acttctatac atagcttgct ttattttagc atatttttta 1074361 agtgaaaagg agggagaagg ttgtctgtct ttttgattgt attatcctgc atcacccttg 1074421 ccttcgcttc aggcgctgtt tactatatca aacttctcag ccaggctgct tcttatccgc 1074481 ccaagagggt tatccggcag aaagcgcttg tttgttcaac cggaaccgcc tttacactat 1074541 gtcttatctt tttcacaaaa ctcctcgctt aaaacatgct gacatgctgc gggcgctctg 1074601 ttcaaaaaaa cctctcccgg aagcggaaga ggttttgtgt gacaattatt tagcagcttc 1074661 cataaagctt gaacgcctta aaatggtttg cacaatcgga taaataatga tcattgagat 1074721 tgtattcagc acagcggccg gcagaacaac agccgcgaac aatgcggcga aaccgcccgg 1074781 taaaccgacg atcaataaag ctgacgatag aaacacaatt cctgataaga tggtcccgat 1074841 cactgtcagc acagcggctg cacctgtttt ccggctcttt ctgaacaaga gaaacaggga 1074901 gaagaacaga aacgctgata cgggtttatc aatgatgtta gggatctgtc cggctggaaa 1074961 cgcggttgta agcgcggaaa tgattccggt cacgatcccg atgacgagta cattttgcac 1075021 ccgcgggaac agcagaatgc ccatgaacat catgatcagc atcatatctg gtttcatgcc 1075081 gcctaaaaag ggcggaataa tggaatgaag cgctgcgccg attgcggcaa acagagccat 1075141 aatgactaac tcttttgttt tcataactat gctctcctct gctaagcttt ttgccctcca 1075201 ataatatgct catcatttat tgcgaaggct ttacagaatg tgttatgcaa acagtatacc 1075261 aaacggacgg tttgcatagc cagacttttt actcattttc ctgctggaat ttcttcatga 1075321 acgcagctaa tttttcacag tcttcgagag agaccgcgtt ataaatagaa gcgcggcagc 1075381 ctcccaccga acggtgtccg ccaaggccga tcatcttcgc atcttttgct ttctgaacga 1075441 atgttttcgt taattcgtca tcccgaagcg tgaatgtgac attcatgcgt gagcggctgt 1075501 cttttctggc atgtccttta tagaagccgt tgctttcatc aatacagctg tagagaacct 1075561 gcgctttttg ttcattgcgc tgttcaacag cttccacacc gccgttttcc ttgagccatt 1075621 ccagaacgag gctcagcata taaatcgcaa atgtcggcgg agtgttgtag agtgaatccg 1075681 ctttgacatg cgtggaatat ttcaagattt ttgggacgtt cgcattttca ttttgcagcc 1075741 agcttttttt catgatgact acagtcacgc cggaagggcc gaggttcttt tgggcgcctc 1075801 cgtagatcac atcaaatttg gacacatcga tttttctgct taaaatatcg ctggacatgt 1075861 cggctacgag cggaattgga gaattcggaa actcctgcca ctgagtgccg aaaattgtat 1075921 tgttggatgt gatatgtaaa tatgcgccgt cttttacatc cgtaaggtca acctctggaa 1075981 tataactgta attgtctgtt tcacttgtag cggtgataga cgtgttcccg aacagtttcg 1076041 tttctgccag tgctttttca gaccaagcgc cggtcatcac aaaatgtgcg gttttttcag 1076101 gtgttaaaaa gttcatcgga agcattgaga attgaaggct tgccccgcct tgaagaaaca 1076161 agatatcgta atcttccgga atgcccatca gttcgattaa gaggcttttc gctttttggt 1076221 gcaccgcttc atactctttg ctgcggtggg aaagctccat aacagacatg ccggattcgt 1076281 taaaatcaat aaattctttc tgtgcttttt gcagaacttc cagtggcagc gctgcaggac 1076341 ctgcgttaaa attcgttgta cgttccatta tgatctctcc ctgttttcca cgttaatgta 1076401 taaaataata caattatcct atcacaaaaa ttcagttttt tgataaaaaa ttagaattat 1076461 caaaagaaat tgacggatgt ttgcgaaatg ttcacaaaat aaaataacct catcttatga 1076521 tgaggccagg cgttttgcga tagaggaaga gatgttctgc agatcctccg gtttataatc 1076581 atcagcatgc gttttccaaa ccgctccgaa tccatctcct tttccgtagc gagggataat 1076641 atgcatatgg tagtggaaca cagattgtcc agctttttcg ccgttattgt tcagcgtatt 1076701 taagccgatc ggttcaaatt catcccggat agcgcgggcg atttttggaa cagcatggaa 1076761 atattgtttt gctaattcat ctgtaaattc atatacattc tcaatatgtg ttttcggaat 1076821 gacaagcgta tggccttttg tcacttggct gatatcaaga aaggcaagta catgttcatc 1076881 ttcatacacc ttcgctgatg gaatgtcgcc ggcaataatt ttacaaaaga tacaattctc 1076941 tgcacaatgc atgagggttc ctccttatga aattgtttag tatgtataca ttcatcgtac 1077001 cacagaaatg cagaaaatag aaaacaggat gaacggcgag cgttcaccct gaatgcagag 1077061 gaagagctta tatgaagaaa atgtgttatg cctttggtaa gcacctcatt tgtcaataaa 1077121 atgaagactt gtttaatgcc taacgattcc tgcgataaac acctcatttg acaatttgct 1077181 tcatacatga agaattcatc aattcagtga agagaaatgg tttgagcatt ggacatgttt 1077241 attttctatc caactgtttc taagacgtct ttgacaaaca cctcattttt cagttgatat 1077301 gcttttcctc tacaactttt atgatgtcca gaaccctgtc tctttatgac agcaaattca 1077361 tcatttgtta aaagggaatt gtttcaaatc aggccttgtt tttggtacta tgaagaaaaa 1077421 cactataagg ggagaaacta tgtctctgct atcggtaaaa gacttgaccg gcggatatac 1077481 aaggaatccg gttttaaaaa acgtatcatt cacccttgaa ccgaatcaaa ttgtcggctt 1077541 aatcgggctg aatggtgctg gtaaaagtac aacaatcaga cacatcatcg ggctgatgga 1077601 cccgcataaa ggttcaatcg aattaaacgg taaaacgttt gctgaggatc cggaaggcta 1077661 ccgttcacaa tttacctata tacctgaaac acctgtttta tacgaagaat tgacgctgat 1077721 ggagcatctt gaactaacag ccatggcata tggactgtca aaagaaacga tggagaaaag 1077781 gctgcctccg ctactaaagg aattccgaat ggaaaagagg ctgaagtggt tcccggccca 1077841 tttttctaaa ggaatgaagc agaaggttat gattatgtgc gcatttttgg cagagcctgc 1077901 gctctacatt attgatgagc cttttctagg gcttgatccg cttgccatta acgcgctgct 1077961 tgaacggatg aatgaagcga aaaaaggcgg ggcgagcgtg ctgatgtcaa cacacatttt 1078021 ggcaacggca gaacgctatt gcgattcgtt tattatttta cataacggcg aggtgcgggc 1078081 gcgcggcacg ctgtcagagc tcagagagca gtttggaatg aaggacgcgg cgctggacga 1078141 tttgtatctt gagcttacaa aggaagacgc tggccatgaa taatatgctt gatatttggc 1078201 agtcgcggct gcaggagcat atcaaagaaa caagaacata catgaaatat atgctcaacg 1078261 atcacctcgt cattgttttg attttttttc tagcgggcgc tgcaagctgg tacagcaaat 1078321 ggatacggga cattcccgct cactttccgt ccttttgggt gatggccgtg ctgttttcgc 1078381 tcgtattgac aagctcttat gtgcgaacgc ttttgaagga ggctgacctt gttttcttat 1078441 tgcctcttga agcaaaaatg gagccttact tgaagcaggc gtttgtctac agctatgtgt 1078501 ctcagctgtt tccgctgatt gcgctgagca tcgttgcgat gccgctttat ttcgcagtca 1078561 ctccgggagc ttcgctcgta tcgtatgccg cggtctttgt ccaactgttg ctgctgaaag 1078621 cgtggaatca ggtaatggaa tggcgaacga ctttccaaaa cgaccgcagc atgaaacgga 1078681 tggacgtcat cattcgcttt gcggcgaata cactcgttct ttattttgtt ttccaatctg 1078741 tttatatgta tgcgcttctc gtctatgtca ttatggctgt tctttatctg tatatgtctt 1078801 ccgcagcaaa acggaaaaca tttaaatggg agagccatat tgagtccgaa ttgagacgaa 1078861 agcagcgttt ctatcggatt gccaacctgt ttactgatgt gccgcatttg cgaaagcaag 1078921 ccaaacgcag agcttatctc gactttttgc tgcggcttgt gccgtttgaa cagcgcaaaa 1078981 catttgccta tatgttcacc cgcgcctttt tgcgttcgag cgattatttg ggcattcttg 1079041 tcagattaac gatcgttttc gcgctgatca ttatgtatgt ctcagccagc ccgctgattg 1079101 ccgcggtttt gactgtgttt gccattttca ttacgggcat tcagcttctg ccgctcttcg 1079161 gtcactttga ccatctggcg cttcaagagc tgtaccctgt gcaaaaagaa acaaagctga 1079221 aaagctattt ctctctatta aaaactgcac ttagtattca agcgctgctg atgtctgttg 1079281 catctgccta tgcagccggc ttgaccggtt ttctgtacgc gctgatcggt tctgccgttc 1079341 tgatttttgt tgttttgcct gcttatatga cgaccaggct gaaaaagcac ggaaagctgt 1079401 gaactgaaaa gaggtaatca aatgacagat aatcagctgc tgatgcagga agctttggaa 1079461 tggaaaatgc attttttgcg aaaggattcc atgtttgaac gcttttcgaa gcgtgtccag 1079521 acgaaggtga atgaacggat tcctgaaaaa atccatacgg tcgtcaccga gagtgtgaaa 1079581 aaaatggtag aagcgacaat ggccggctct aatatcatca cctataaaaa ggatacaagt 1079641 gcactgtcgc tcagtgaaaa aaacgaattg gcgaaaaaaa cgattgtttc ttatcaaaaa 1079701 gtggcagctg ctgagggagt cggcaccgga gcgggcggca tttttttaag cattgctgat 1079761 tttccgctgc tgctttcaat taagatgaag tgtttattta ccttgtcttc catttacggc 1079821 tttgatgtca aggatgcaca agaaaggata tttttgctgc tcgtgtttca gcttgcgttt 1079881 tcgagtgatg atggccgtaa gtcgcttttt tctgtcatcg aaaattggga gacggagaaa 1079941 aagagcatcg actggagagt gttccagcag gaatatcgcg attatatcga cgtcgtgaag 1080001 ctttttcagc ttttgccggg cgtaggagcg gcagtcggcg gaattgccaa ttataagctg 1080061 cttgctcagc ttggagaaac ggcaagacat gtttttcatc tgaggatatt aaaggaaaca 1080121 gccggagaat aaacactccg gctgtttttt tatagctgat gataggtgat cgcagcgccg 1080181 gcaaggacct tggccgctgt cagcatggct ttttcgttga tatcaaattt cggatggtgg 1080241 tgggaataga ctcgctctgg ctgttcggga gcggcgcctg taaagaaaaa agtgcccttc 1080301 acgttttgta agtaataagc aaaatcctcg ccgcccattt gtggttcacc gtcaatgacc 1080361 tgctgaacgc cctcggtatt ctttgcggtg ctcaccaagt ggttcgtttc tgcaggatgg 1080421 ttcacaaccg ctggataacc ctgttcatag gtgtactcat aggacgcgcc gtgcatgctg 1080481 catattcctt ttacaaccgc ttcaatttct ttctccagaa tgtcccggac attttcatca 1080541 aaagaacgcg ctgtgccgat gagtactgct tggtctgcga tgacattaaa cggattgtcg 1080601 gcgatgaagg agcctgtcga aatgacggcg gattgaatcg gattgacttt gcggctgaca 1080661 atgtgctgca aagaggaaac gatttgcgaa ccgattagga cggcgtcttt agtatcatgc 1080721 ggatgagcgc cgtggccgcc ctttccgaag actttaatcg taaatcggtc tgccgccgcc 1080781 attacggcgc cggggcggca gagaatagtt ccgagcggct cagttgccca aagatgagtg 1080841 ccgaatatca catccgtgtt ttcgagacat ccgtcatcaa tcattggctt tgcgcctcca 1080901 ggataatatt cttctgcatg ctggtggatc atcacaaatg ttcccttcag ttcatgtctg 1080961 ttttggtgaa ggaccttggc cactgcgaga agagctgcgg tgtggccgtc gtggccgcat 1081021 gcatgcatga caccaggcac tttggaggcg taagggacat ctttttcatc ttgaatgggg 1081081 agagcgtcaa agtcggccct caaagcgact gtagggccgg gttcgcttcc ttctatattt 1081141 gctaaaaccc ctctaccgcc aacgtttgtg cggattggga ctcctaacga ttcataatag 1081201 gaagcaataa atgcggcggt tttttcttct tgaaatgaga gctcaggata catatgaaaa 1081261 tggcgcctga tctcaaccat ttcttcaaaa cagccgtcga gctgtttgtt tatctctttc 1081321 tgcagtgtgg atatggacaa agccgcttcc cccttttcta tgcttttcca tgattgtata 1081381 gaaaaagtct gaatatttca actcatgctg ttttaaagca tcatcacagc tgcgagggtt 1081441 gtcaccaaaa ggccaatcgc gacgggaatg aagttttttc tggcaagctc aaaaggatca 1081501 actttgcaaa tggccgcggc gggaatcaaa gcccatggga ccagtgttcc tccgcccacc 1081561 cagatggcag agatttgtcc gagcgcggtc agaatagcgg gatcggcatg gagagcggac 1081621 gaaaagagct ttgcgatgga gccggcgaga gaaatgccag aaaatcctga gccgtcaagg 1081681 cctgttatgg ctccagcggc agttaatgca gtggcggcaa gctcctttga cataggcatc 1081741 atatgggata aagcaatgcc aagatcgttg acaatgccgt gggaaccttt agggagtgaa 1081801 gtgcccagta tgctttcata gcctgagtcg ccaagataaa agaaagcggc aatcgggatg 1081861 acggggccga aaaccttaaa accgaactta aatccgtcaa taaaatagcc ggtgattttt 1081921 tcaagccctt tatgcttata cacgaaaaaa tgaacggtaa agaggataca aattgcagac 1081981 ccgccaatta acgcggttgc atcatttcct tgtaggttaa acaagagcat gcaggcgata 1082041 tctgcaagaa aggcaagcgg aatcaaaaaa gccagtatgg accgcaggcg ttttggcaag 1082101 tacagcgagt tgtcttgttc gccggaaaga acgggggaaa aagaagtggg atgctcctgt 1082161 tttttgcgtt cgcgctgaat catgataaag gcagcagttg ttgttgtcac acccataatc 1082221 agcacaagcg gaatactggc cgagacgaca tcaccgactg gaatgcctgc tgcatccgca 1082281 gtcagctttg gcgccgcctg aatgacaaag tctcctgaca gggcaaaacc gtgtccgaat 1082341 aagttcatgg ccatggccgc ggcaagaggc gtcaaaccgg cacgtgcggc tgcggggagc 1082401 aggacggcgc cgatcaaagc gacacccgga gaaggccaga agaatagaga aatggcgaac 1082461 atcaggcctc caatcagcca ataggcagtc acaggccctc tcacaaggct tgcaaaggga 1082521 gaaatcatcg cttcatttat ccctgttttt gttaacaaat cactcattga aacgataaag 1082581 caaatgatga aaatcgtggg cagcagttcg ccggccgcat agataaagct gtggaataaa 1082641 ctgctgacag aagctgaaag tgaatggctg gcccatagcg atatgataaa aatgccgaat 1082701 agagaaataa atgtcgtgtc ttttctcagc agcataaata ggataattgc accgataaaa 1082761 aacacataca gaacatggac aggcaaaatc ccgacttcca tcatcgatca ctccttccgc 1082821 ttacagatta ttcataggcg ggcggaaggt gccgggacag aggggagggt tatgatggaa 1082881 gatgaacatt gatctgtttc agctgctcaa tcagatgatg ccttaatcct ctattcgctt 1082941 tttgcagatg ttttgggaag cattcaggag aaaaaatgac gcacccttca gcaagccagt 1083001 tttttctata ggcgatgatg ctttccgatg gctctatatg agttatcctc gtgctgcatc 1083061 tcgtactcat caaatccgaa ctgaaaaccg cagcacgggc agatttcatg agaatgattg 1083121 ccttcatgat catatggcgg ttcagccaat ccttaaaccc gcagactggg caagtatgct 1083181 tcattttgct ttcctcccaa taaaataagc tgccggacat gccggcagct attcgacagc 1083241 gaaatatgtg gtgacatagg aaggccggga gaagatcgac gttgtgtcaa ttccggcaga 1083301 tgtatcgcgt tttttgtggg cttctttgta agaaccggac tgctgccagt cttgaaaggc 1083361 gctttccgtt tcccacaagg tcagaatgac ataggtgtca ctgtcaagcg gacggagcac 1083421 tcgaattgct tcaaagccag gctcgttttc gacttttccc gctctgtttt taaatctgtt 1083481 ttcaaacagc ggacgccctt cctgagtaac ggcaatattg ttcaatactg caaaaccggg 1083541 atgtttgatc tctccgactt ggtcaatgac ttcataagcg tgtggtgcct ggaaaacggt 1083601 atctccgttt gtttcatgaa ttaaaatggc gttttcctgc ccctgcatca aaaggatatt 1083661 ttctgaggga tgcttctgta cgatcgtttt taaaaaatcg gctgtcccat atgtaatata 1083721 aaccttcata tcagccacct cctgcttgct agtatatcaa aacaatggta taagtttcta 1083781 ttggcgagtg cttcgaacat aattccaaac aatttttccc atactacctt tagaaaggcg 1083841 aggtgagttc atgtttaaga taaagaaaaa gaaacttttt atacctatca ttattttagt 1083901 gttaactgct tttctcgctt taataggata tatttcaatt atttttctcg gccattatgt 1083961 catagatgaa aaaaagctta ttcttcatgc ttcttcaaaa attgttgatc aaaacggaga 1084021 tgaggttgca agcctgtata cagaaaatcg cgagccggtc tcgatcaatg agattcctaa 1084081 gcaggtcaga gaagcgttta tcgctgttga ggataaaagg ttctatgagc atcacggcat 1084141 tgatgcaaaa tccgtcggaa gggcagtgta ccgcgatata ttagcaggcg gaaaggtgga 1084201 aggcggaagc acgatcaccc agcagcttgc caaaaatatt tttctgacac atgacaaaac 1084261 atttctaaga aaaacaaaag aagtgatcat tgcgattaat cttgaacggg attacagcaa 1084321 ggacaagctg cttgaaatgt atttaaacca gctttacttc ggacacgggg tttacggcat 1084381 acaagcggcg tcccactatt attttaataa agaagtaaaa gatttgactg tatctgaagg 1084441 cgctgttttg gccgctattc cgaaggcgcc ttctacgtac tctccaattt tgcaccctga 1084501 taaaaataag gagcggcgtg atacaattct aggtatgatg aatgaccaag gctatatcag 1084561 tgcgaaagag gctgtcaccg cacagggccg gacgcttgga ctgcatgtga agaaacagtc 1084621 ggaaacacct tggtttgaca gctacattga ccttgtgatc aaagaggcgg aagacaagta 1084681 ttccatttcc ggagagcagc ttcttcaagg cggatacacg atcaaggtgc cgctcgattc 1084741 gaagctgcag aagacggctt accaggtgat gaaagaggga agctattatc ccggaacaga 1084801 tcagaatgcc gagggaagcg cggtctttat taataacaag acaggcggtg tagaagcggc 1084861 catcggcgga agggattaca catccaaagg atataaccgt gtcacagctg tccgccagcc 1084921 gggttccaca tttaagccgc ttgctgtata cggaccggcg atgcaggaaa agaaatttaa 1084981 gccatattct ctattgaagg atgagttgca gtcctacgga gattatacgc cgaaaaacta 1085041 cgacagccgg tatgagggcg aagtcactat gtctgacgcc attacgtaca gcaaaaacgc 1085101 gccggctgtc tggacgctga atgagatcgg cgtcgaaaca gggaaatctt atttgaaagc 1085161 aaacggcatt gatatccctg atgaaggcct tgctcttgct ctaggcggct tggaaaaagg 1085221 cgtttcaccg ctccagcttg ccggcgcgtt tcatacattt gccgcgaatg gaacgtatac 1085281 tgaacccttc tttatctcga gcataataga tgaagacgga gaaacaatag ccgatcataa 1085341 agaagaagga aagcgggtat tcagcaagca gacgtcttgg aatatgacga gaatgctgca 1085401 gcaggtagtc aaaaagggaa cggccacgtc cggcacctat cacggcgacc tggcgggaaa 1085461 aacaggttca acatcttata caggcgtctc cggcgcgaca aaggacgcct ggtttgcagg 1085521 ctatacgccg aaaataaccg gggcagtctg gatgggctat gacaaaacgg atcaaaacca 1085581 ttatttgaaa gccgggagct catacccgac gcggctgttt aaggatattt tgacacaggc 1085641 aggagaaacc ggtcatgtgt tcacaaagcc taaaaacgtt aaagaactgg aaagcccgat 1085701 tgagctgaag ccggtcaaaa cactcacagc cgattacaca tttaaagcag cggggctctt 1085761 tactattgaa ttaaagtggg acgctcaaga ggatgatcgg gccgtataca gaatttatgt 1085821 aaacaaggac ggcgaggaga cgcttcttga ttcggttgaa gggaagggaa gctatgaaat 1085881 tccttatgcc aacttatttt cgggcgcgtc ttataaaatt gtgccttata atacacagac 1085941 aaaaagagaa ggggaaggaa ccgattacgt tcagccaaaa ttgttttcct cttaatggaa 1086001 ttcggcgatt ttttgaactt tgagctacat ttctatacca tttgcctaaa acaaggtata 1086061 gtgtaataag tcaagaaata cgaacgtatg gttgccgtat gaaaggtgga aatcagatga 1086121 gtaaacgaga aacgtttaac gagacgtttt taaaagctgc gcggggagaa aaagcggatc 1086181 acacgcctgt gtggtatatg aggcaagcag ggcgctcaca gccggaatac cgcaagctga 1086241 aggaaaagta cggattgttt gagatcacac atcagcccga actttgtgcg tatgtcacaa 1086301 gactgccggt tgagcaatac ggagtcgatg ctgcaatcct ttataaagat atcatgacgc 1086361 cgctgccgtc aatcggtgtg gatgttgaaa tcaaaaacgg gatcggtcct gtgattgatc 1086421 agccaatccg gtctctggcg gacattgaaa aactcggcca gattgatccg gaacaggacg 1086481 tgccgtacgt gcttgagacg attaaactgc ttgtcaatga gcagctgaac gtcccgctca 1086541 tcggtttctc aggtgcgcct tttacgcttg caagctatat gatcgaaggc ggcccgtcga 1086601 aaaactacaa taaaacaaaa gccttcatgt acagcatgcc agatgcatgg aatctgctga 1086661 tgtccaagct tgccgacatg atcatcgtgt acgtgaaagc gcagattgag gcaggcgcaa 1086721 aagcgattca aatctttgat tcgtgggtcg gcgcattgaa tcaggcagat tacagaacat 1086781 acatcaaacc cgtgatgaac cggatctttt cagagctcgc aaaggagaat gtgccgctga 1086841 tcatgtttgg cgttggcgca agccatcttg caggtgattg gcatgacctt cctctcgatg 1086901 ttgtcgggct tgactggaga ctcggcattg atgaagccag atcaaaagga attactaaaa 1086961 cagtgcaggg caacctggac ccgtccattt tgcttgcgcc atgggaagtc attgagcaga 1087021 aaacgaagga aatacttgat cagggtatgg agtcagacgg cttcattttc aatcttggcc 1087081 atggggtatt tcctgatgtc agtcccgagg ttttgaaaaa actgacagca tttgtccatg 1087141 aatattcaca aaacaaaaaa atgggtcaat attcctaagc atatcttttg gtatcttaat 1087201 gatatcctgt caaaatgttt gtatcagatc attaaagagg gtgtaaacag tgagtagaaa 1087261 gaaaatgggg cttctcgtga tggcgtacgg cacgccttat aaggaagaag atattgaacg 1087321 ttattataca catatcagaa gaggcagaaa gcctgaacct gaaatgcttc aagatttgaa 1087381 agacagatac gaagcgattg gcggcatttc accgcttgcc caaatcacag aacagcaggc 1087441 gcataatctg gaacagcact tgaatgaaat tcaggatgag attacgttta aagcgtatat 1087501 cggactgaag catatcgagc cgtttattga agacgccgta gcagagatgc ataaggatgg 1087561 cattacagaa gcagtcagca tcgtgctggc gccgcatttc tccacgttca gcgttcagtc 1087621 ctacaacaaa cgcgccaaag aagaggctga aaaactcggc ggcttaacga ttacgtcagt 1087681 tgaaagctgg tacgatgaac cgaagttcgt gacatattgg gttgaccgag tgaaggaaac 1087741 atatgcgtca atgcctgagg atgaaagaga aaacgcaatg ctcatcgtat ccgcacacag 1087801 cctgccggaa aaaatcaaag aatttggaga cccgtacccg gaccagcttc atgaatcggc 1087861 gaaattaatt gctgaaggcg caggcgtttc cgaatatgct gtcggctggc aaagtgaagg 1087921 gaacacgcct gatccttggc tcggacccga tgttcaggat ttaacacgtg atttattcga 1087981 acaaaaaggc tatcaagcat ttgtatatgt tcctgttggg tttgtcgcgg atcacttaga 1088041 agtgctttat gataatgatt atgaatgcaa agtggttact gacgatatcg gcgcaagcta 1088101 ttaccggccg gaaatgccaa atgccaagcc tgaatttatt gatgctttgg caacagtcgt 1088161 attaaaaaaa ttaggacgtt aaagaaggcg atgaacatga gtgacggcaa aaaacatgta 1088221 gtcatcatcg gcggcggcat taccggttta gccgccgcct tctatatgga aaaagaaatc 1088281 aaagaaaaga atctgccgct tgagctgaca cttgttgagg caagtccgag agtcggcggg 1088341 aaaatccaga ctgtcaagaa agacggctat atcatcgaaa gagggccaga ctcatttctg 1088401 gaacgaaaga aaagcgcccc gcagcttgtt aaagacttag gtcttgagca tttgcttgtc 1088461 aacaatgcga ccgggcaatc ctatgtgctt gtaaaccgca ccctgcatcc aatgccgaag 1088521 ggcgctgtaa tggggatacc gacaaaaatt gcgccgtttg tttctacggg tctgttttcc 1088581 ttgtccggga aggcgagagc tgctatggat ttcatcctgc ctgcaagcaa aacaaaggat 1088641 gatcagtcat tgggagaatt cttccgcaga cgtgtcggag atgaagtggt cgagaactta 1088701 atcgagccgc tactatcagg gatctacgca ggcgacattg acaagctcag cctgatgtcg 1088761 acatttccgc aattttatca gacggaacaa aagcatagaa gcctgattct cggcatgaaa 1088821 aaaacaaggc ctcaaggctc aggccagcag ctgacggcaa aaaaacaagg gcagttccaa 1088881 actctgtcaa ccggtttgca gacccttgta gaagagatcg aaaagcagtt aaagctgacg 1088941 aaggtgtata aaggcacaaa agtgaccaaa cttagccata gcggctcttg ctattcgctc 1089001 gaactggata acggcgtcac acttgatgct gattcagtaa ttgtgactgc tccgcataaa 1089061 gcggctgcgg gaatgctttc tgagcttcct gccatttctc atttgaaaaa tatgcactcc 1089121 acatccgtgg caaacgtcgc tttaggtttc cctgaaggct ccgtccaaat ggagcatgag 1089181 ggcacgggtt ttgtcatttc aagaaacagt gactttgcga tcacagcctg tacgtggacg 1089241 aataaaaaat ggccgcacgc agcgccggaa ggcaaaacgc tgcttcgggc atatgtcgga 1089301 aaagccggag acgaatccat tgtcgatcta tcagataatg acattatcaa cattgtgtta 1089361 gaagacttaa agaaagtcat gaacataaac ggcgagccgg aaatgacatg tgtaacccga 1089421 tggcatgaaa gcatgccgca gtaccatgtc ggccataagc agcgtatcaa ggagctgcgt 1089481 gaagcacttg catctgcgta tccgggtgtt tatatgacag gcgcttcttt cgaaggtgtc 1089541 ggcattcccg actgcattga tcaaggaaaa gctgccgtgt ctgacgcgct tacctattta 1089601 ttcagctaaa acctccgctt tatcgcggag gtttttttga tgtgcaatgg caatattgtg 1089661 taaaaaatga ttgaattgaa cagcaggtta tgatacattt gcatatgtac ttaatgacta 1089721 aaatgttcaa acggtcagtt tcgaggtgaa tacaatgtca atagatcgaa aaaagctcat 1089781 tttggaggcg gctacaaagt ctttcacgca gttcgggtat aaagcgacga caatggatct 1089841 tgtcgcaaaa cttgcgaacg tggggaaggg aaccatttat acttttttca aaaacaaaga 1089901 agagctgttt gacgagattt tcactacttt attaaaggaa atgaagcaaa aagcggatga 1089961 agcgatggag ccgagccttc cgttccatga aaatgtgcac agagcgctgt ttgccattct 1090021 ggagttcagg aaaacacatc agctgacgat taaaattttc caagagaatg ccgagattgg 1090081 tacaatggca gttcaggaag tgatccagaa aatggagcga tccatcctgt cttatatcaa 1090141 aagcaagatt gaagacggga tcaaaagcgg cgcaatcaag ccgtgcgacc ctgagctgac 1090201 agcctttgtg atgctgaagc tttatatcgc gctcattttt gactgggaaa aacaacaccc 1090261 cccgcttgat aaagagacaa ttgcgggact gcttgaattg tatgttgtca aaggattgtc 1090321 agcgaactag ataatccttt ctctttgcaa gaaaatgacc attttttatg atgagtcagt 1090381 tttagaatgg aggcatcagg atgaacacaa tacgaagtca gtggaaagac atcgtaacaa 1090441 gtaaaaaatt attgattccc atcatcgcca ttttgtttgt cccgcttatt tacagcggcg 1090501 tattcttaaa ggcttattgg gacccgtacg gcacagttga ccagctgcct gtcgttgtcg 1090561 tcaaccaaga caagggagca acgtatgaag gagaaaaact tcaaatcggt gatgatctgg 1090621 tcaaagaatt aaaggataat aacaactttg attggcattt ttccaatgat ctcgaccaat 1090681 cgttaaagga cttattgaat caaaaatatt atttagttgt cgagattcct gaggattttt 1090741 ctaagaatgc cagcactgta ttagacaaaa atccgaaaaa attggatctg aaataccata 1090801 caaatgcagg ttctaactat gtaggggcaa cgatcggcga aaaagcgatt gataaactga 1090861 aagcctctgt ttcaaaagaa gtgaccgagc aatatacgaa agttattttt gataacttta 1090921 aagatatcgc aaaaggtttg agcgacgcga gcagcggcgc gaaaaaaatt gatgacggca 1090981 caaaggatgc gaaaaacgga agcgcccagc tgaaagaaaa tctggcgaag ctgaaggaaa 1091041 gcaccgctac catcagtgac aaaacagcgc agcttgcaga tggagcggct caggtgacga 1091101 gcggcatcca atcacttgac agctcgctcg gtaaattcca ggacagcagc aaccagattt 1091161 atgataaatc tagtcagctt gcagcaggat caggcgagct gacaagcaag atgaatgaac 1091221 ttcttgccgg acttcaaaat gtgcagaagg gtacgcctaa tcttactaac gggttggatc 1091281 agctcaacag taaagtccaa gaaggttctg agaaagcggc aaaagcggaa aagatcatta 1091341 atgcgctcga tttaacgaag cttgaaactg ctgtaaacaa tctggaaaag tcagaaactg 1091401 cgatgaagga attcaaaaaa cagctgactg actttgaaaa cagtttgaaa aaccgtgatc 1091461 aggcatttaa aaatgtcatc aattcgagtg acttcttaac agcggagcaa aaaagccagc 1091521 tgattaattc tgttgagaaa aagcttccgc aagttgatgc gcctgatttt gatcaaatat 1091581 taagccagct acctacagct gatcagctgc ctgacatcgc aacgataaaa agctctcttg 1091641 aagacgtgaa agcgcaggtg gcgcaggtga aagccatgcc ggaagctaca tctaagcttt 1091701 ataacggcgc aaaaacaatc caagatgcga ttgacagatt aactgaggga gctgataaga 1091761 tatacaacgg ttctcagaag ctgacagatg gccaaactaa actgacagcg ggcatcggtg 1091821 aatataataa gcagttcgca aaagcaaaag cgggctcaga gcaattggtg acaggaagca 1091881 gccaagtatc cggcggattg tttaagctgt tagacgggtc taaacaggtc caaagcggat 1091941 catcaaaact tgcagacgga tctgcatcac ttgatacagg tttaggcaag ctattggacg 1092001 gcacaggaga gctgtctagt aagctgaagg atgcggctga ccaaacagga gatatcgatg 1092061 ctgatgatca aacatacggc atgtttgcgg atccggttaa aaccaaagat gatgccattc 1092121 attccgttcc taactatgga acagggctga caccttatat cctgtcaatg ggcttgtatg 1092181 tcggcggcat catgctgacg gttgtcttcc cgctgaagga agcgtcagga cgtccgagaa 1092241 acggttttga gtggttcttc agcaaattca atgtcatgat gcttgtagga atcattcaat 1092301 cattgattgt ggcgacggtt cttctattgg gaattggtct tgaggtagag agcacgtgga 1092361 gattttacgt gtttacgatc attacgagtc tcgctttcct ggcgataatt caatttttgg 1092421 ctacaacgat gggcaacccg gggcgattta tcgcagtcat tattttagtg ctgcagctgg 1092481 gagcgagcgg aggaaccttc ccgctggaat tgcttccgaa tttctatcag gtcatccacg 1092541 gcgcattgcc gatgacctac agcattaacg gattcagagc agtcatttca aacggtgact 1092601 ttggctacat gtggcagatg gccggcgtct taatcggcat tgccctcgtc atgattgcac 1092661 taagcattac ttactttaca atgttaagcc ggaaggaaga aacatcagaa gaacagccgg 1092721 cttcataaag aaaaagaact tgtttccttg gaaacaagtt ctttttttgt tacatccccc 1092781 atttaataag caatcctgta taggttaatc cgccgccaaa cccgaaaagc aaaacgattt 1092841 gatctttttt cagcttcccg gctttcactg cgagatcgag cgccaaaaca attgaaaccg 1092901 aagacgtgtt tccgtagtgc tcaacactag tgagcgtttt ttcaatcggg aacggtgttt 1092961 tttcacaaat tgactcgatc atgcgcaagt tggcgctgtg aggaacaaac caatcgagat 1093021 catcggagct gagtcctgct ttatgtaaaa gccgttcaaa ttcgccaggg acggttcttg 1093081 cggcccattt atatacctcg cgtccgtttt gcaccatttt tccggaaccg acaagctgca 1093141 caccgtttat ttcatttcgc agtccggcac gatacaaaat atcgccgccg ttcccgcttg 1093201 ttccttgtac agacgcaaga aatcccggcg tctcttcatc tcgttctact aacagcgcac 1093261 ccgcggcatc gccgaacagt acgcatgtcg ttcgatcggt ataatcggtt acctttgata 1093321 acgtctctcc ggcgatgacg agaatttttt gatgaaggcc agatgtgatc aatccatttg 1093381 ccaaatggag gccgtatgtc agcccggcgc atgtcgcatt aatatccagc gcgccggtgc 1093441 tttcccagcc gaaatattcc tgtacgcggc atgccgtact cggaaaggcg taatcggatg 1093501 tggttgtggc aacgaggatc atatcgacat catcaagcgt tcctttataa cggctcttga 1093561 gattcttcac cgcttctatg cataaatcag aggtaaattg atgttcatcc gcaatccggc 1093621 gttctctcat tcctgtgcgc tgaacgatcc attcatcaga ggtatcaacg atcttttcta 1093681 aatctgcatt ggttaaacgt ctgctcggcg cataggtgcc gatagctgta atttttgctt 1093741 ttgacatatg aatcactcct tatggtcaga ttataacact agatattagt atctggtact 1093801 aaaaagaagg tttttttaca aaaaaagaga agtgtagata ggaatctatg aaaaagaaaa 1093861 aggaggctga aaaatggtca gtcaagaagc agtagtcttt ttggcattat ccggggctat 1093921 tgcgtttctg ttgccaatcg ggctgattgt atggtttaag cgaaagtatg gtgcctcgct 1093981 taaagtgttt tttattggcg ctctcacgtt ttttgtcttc gctcagctgc tggaaggcgg 1094041 cgttcatgtt tatgtactgc aagtgaatga aatgacgaaa gaagcgatgc agcatccatt 1094101 atggtatggc atttacggct gcttgatggc cggcattttt gaggagtgcg gaaggtattt 1094161 gatgatgcga ttttttatga agcgccatca tacttgggca gatggtctgg ctttcggggc 1094221 aggccatggc gggcttgaag ccatcctgat tacaggcttg tcctctatct cacttattgt 1094281 atacgcattt gcaatcaata gcgggacgtt tgaacagctt ttggtcaatg gcgacgtcaa 1094341 acaggcgctt ttgccgatac aggagcagct gctgcatact ccttcgtatg aatggatgct 1094401 gggcggaata gaaagaatca gtgccattgc cgtccagatt ggtctgtctc tgcttgtttt 1094461 gtacgcggtt aaaaaccgcc ggccgctgtt tttgctgtat tctattcttt tacatgcact 1094521 gtttaatgtc ccggcggttt tatatcaaag aggaatcata gagcatgctg cagctgttga 1094581 aatcattgtt gctcttatag cggctttatc agtttattgg attgtaaaag caaaaagggt 1094641 gtttcaataa aaggtccaag cagcagcaat gcccgcttgg aaaaatgtga atggaaatat 1094701 tcattaagca tgggtcatca gaatatttct gattcagtct ttagcaatga cagcaagaat 1094761 gtctgtgttt tttacaagag aaacaatggt gtttcttttt cttcttctcg caagggtcat 1094821 ggcattcttt ctttttcttg caatggtcgt ggaaatcttt atcgaaccac tcgtcaaaga 1094881 accaaaaatc atcgaaccaa tcgtgacaac gacatttctg ttcatgtgaa tgacgacagc 1094941 acatagaaat ccctcctctt cccatgctct ctacagcata tgagagattg ataggaaaag 1095001 attggacggg tccctcggga aaagagtata ttttaagtag aaaataaaag gaggaatgcc 1095061 ctatgacgtc cgtacgtaaa acgatggagc tcattaaaga acttgtatcg atcccaagcc 1095121 cgacaggaaa tacatatgag gtgatcaatt atattgaaag ccttttaaaa gaatggaagg 1095181 tagaaacggt tcggaaccac aagggcggct taattgcaac gcttccagga cgcgacacat 1095241 cccggcatcg catgctgaca gcgcacgttg acaccctcgg cgctatggtg aaggaaatta 1095301 aagcggacgg ccggctgaaa atcgacttaa tcggcgggtt ccgctacaac tcgattgagg 1095361 gggagtattg ccaaattgaa accgcctcgg gaaaaatgta cacaggcaca atcttaatgc 1095421 atcaaacgtc tgtgcacgta tacaaagacg cgggaaaggc tgagcggaat caagagaata 1095481 tggagatccg cctagatgaa cctgttcact gccggaaaga tacggaggag cttggcattg 1095541 gcgtcggaga ctttgtgtcg tttgatccac gtgtcgagat cacatcaagc ggatttatta 1095601 aatcgcgcca tttggatgac aaagcaagcg tcgccttatt gctccgctta attcatgaaa 1095661 ttcaaacaga agacattgag ctgccgtata caacccattt tcttatttcc aataatgaag 1095721 aaatcggtta cggcgggaat tcgaatattc ctcctgaaac agttgaatat ttggcggttg 1095781 atatgggcgc tatcggtgac gggcaggcga cggatgaata ttcagtatca atctgtgtga 1095841 aggatgcgag cgggccgtat cattatcagc tcagaaagca tttagttcaa ttagccgaga 1095901 agcatcatat tgactataag cttgatatat atccgtacta cgggtctgat gcgtcagcag 1095961 cgatcaaatc cgggcatgat attgtgcatg gcctcatagg gccgggaatt gacgcttccc 1096021 atgcatttga acgcacccat aaatcatctc ttcgccatac cgctaagctt ctgtattact 1096081 atgtacagtc accaatggta taagggggag gaccaatgaa gatttataag ctgaaaagca 1096141 cattcggttg ggaaggtgat gacgggttgg gagaacagct gattcagcag atccttgccg 1096201 gagaaaaaag cgccacgtgc gcgccgaaat cattgtattc aaaagatgaa ttgagggacg 1096261 tttatcaaac agcgggtcag cttgttaccg tttatgataa acatgacaat ccaagatgca 1096321 atataaaagt aacagatgtc tttgaaacca cctttggtgc gcctgatatg aggttagtca 1096381 aaggagaggg caatggagac cgaattgagg agtttcaaga ggatcatcgg atggcatggg 1096441 cggaactgat caaaagcggt gaactggagc tgaatgagga tactgttttg attacagagt 1096501 tgtttgtgct tgttaaagat taaaaaagcc tgcggggcaa gaaccccgca ggcttttcat 1096561 taaccagaaa tggttgcgtt ttgttctgtt ttcgattggg acataacagt ttctgctttc 1096621 gcaggattaa acatgccttc ccatttagac atcacaacgg cagcaagcgc gttaccagtc 1096681 aggttgacaa ctgtacgtgc catatccatg atgcggtcta cgccggcaat aaaggcaagt 1096741 ccttcagccg gaacgccgat ggtgccaagc gttgcaagca agacaacaaa agaagtacca 1096801 ggtacggcag ccatcccttt ggatgtcacc attaagacga gcacaagcgt aatttggtgc 1096861 caaatcgtca aatcaatgcc atatacctgt gctaaaaaga gtgcggcaat agattgatag 1096921 agaacggaac cgtctaagtt aaacgtgtaa ccgatcggaa tgacaaatga aacaatgcct 1096981 tttggacatc cgattttctc cattttttcc atgatacgcg gaagaaccgt ttcagagctg 1097041 gacgtactga acgccagtaa gatttcgtcc ttcatgtaag caaggaactt gaagatgctg 1097101 atgccggcaa tttttgcgac aatcccgaaa ataacaatta agaagaaagc aagcgcgaca 1097161 taaaccaatc cgacgagctt tccgagagag ataagagaac cgagtccgaa tttagacaca 1097221 gtcactccga taagagcgaa aacgccgaat ggcgccactt tcatcacaag gtttacaacg 1097281 tggaacatgg catgggatac accttcaaaa aaggctaata caggcttgcc tctttcaccg 1097341 atcgcggaaa tacccaatgc aaatagtact gtaaagcaga tgatggctag aagatcccct 1097401 tcgaccaatg actggaagaa gtttgtcggc acaatatgga ggaacgtttc cgccactgat 1097461 ttattacttt gttctttttc agtttcaaca tattgactga tgtccgattt ttgagcttcg 1097521 tgtatattaa ctcctgtacc cggatggaag atgtttgcaa gggctagtcc gagaataatg 1097581 gcaaaagtcg tgatgatctc gaagtacaga atcgttctga agcctaattt accgacttgc 1097641 tttccatttc ctgcaccggc tacaccgatg attaagctgg agacaacaat aggaatcact 1097701 atcattttga ttaagcgtaa aaagagatcc ccgattggct gcaggtaagt aggcaatgct 1097761 gggttgccat accaaatgac gccaacaatg acacctagaa taagtccaac gaatatttgt 1097821 gtggctaatc caaacttaat tcttttcata gattacctcc caaaaaacaa agtatcaaca 1097881 tatatcatga atagacatat atttaatctc actattagat caaattataa tagataagaa 1097941 atcaattcgt ctatagtaaa ttatatttcg aaaataaaga atattcaatg acattatgat 1098001 aatcaccaga attatctaaa aacaggtgag ctttgaccta acctgactat tatttcaaaa 1098061 ttaagagata tgtgaaaaaa taagaaaatc ccacgcgtaa ggcgcgggat tttcgctcat 1098121 tacaaatcgt ttacttttat acagtcattg cagatattac cataacactc atgctgctct 1098181 tctatctttt ttccgcattc cgcacacttt ttcgaaggca ggtttctaaa aaattctgtg 1098241 attttcccca gcataaccaa tccctctttc ccctttgtag tgatttcatt gtaatataac 1098301 agattacaaa aatcaataac tgttttgata caatgtttaa aacatgcttt tttcaagaaa 1098361 aatgggtata ttgaaggagg accaattttt ttgaaaagat aggaggacat tatgaaagtt 1098421 acagttatcg gatgctatgg cggttttccg gccgcaaatg aagcgacgtc aggctatttg 1098481 tttcagtcag gtgattactc tctgcttgtt gattgcggca gtgccgtatt gtctaagctg 1098541 ttcggatatg tgccggcgga aaagctggat gcggtcgttc tgtctcatta tcaccatgac 1098601 catatcgctg atatcggacc gctgcaattt gccaagcaag tcggttcgtt tctcggcaaa 1098661 ggagagcata cgcttccgat ttacggacat gatgctgata tagaacagtt tcaaaagctt 1098721 acatataaaa cacatacaaa agggatcgcc tatcagccgg atcagccgct gactgccggt 1098781 ccgtttacga tcaccttttt aaaaacgatt cacccggtga cgtgctatgc catgcggatt 1098841 actgacggca gccacactgt cgtttatact gctgattcca gctatcagga ttcatttata 1098901 ccgttttcga aagatgctga tttattgatc tcagaatgca atttttatgc cgatcaagac 1098961 ggaacaagtg caggccatat gaacagcctg gaagctgggc gcattgcaaa agaagccgga 1099021 gcgggagaac tgctgctgac acatttgccg cattttggcg tgcatgacaa ccttcgcaaa 1099081 gaagcgaaaa ccgtttttaa cggagaagtg aatattgcga aatcaggttt tgtgtgggaa 1099141 ggataaagga ggagcaccat gttatttata gacaatcaaa atatcaatga tccgcggatc 1099201 aatcttgcta tcgaggagta ctgtgtaaag catttagacc ctgaacagca atatttgctc 1099261 ttttatgtga atcaaccgtc tattatcatt gggaaaaacc aaaatacaat agaagaaatc 1099321 aatacaaaat atgttgagga aaacgggatt atcgtcgtcc gccgtttatc aggcgggggc 1099381 gctgtgtacc atgatctggg gaacttgaac ttcagcttta ttaccaagga tgacggggac 1099441 agctttcata actttaaaaa attcactgag ccagtgattc aggcgttaca tcagcttggg 1099501 gttgaagccg aattaagcgg ccggaacgac attgtagtag atggccggaa aatatccgga 1099561 aacgctcagt ttgcaacgaa aggccgtatt ttcagccacg gcaccctcat gtttgattca 1099621 gccattgatc atgttgtatc agcattaaag gtgaaaaagg ataaaattga atcaaaaggc 1099681 atcaaatcga tcagaagccg agtggcaaac atcagtgagt ttctcgatga taaaatgacc 1099741 accgaagaat tccgcagcca tttgcttcgc catattttta acacaaacga cgttggaaac 1099801 gtgccggagt ataagctgac ggaaaaagat tgggagacca ttcatcaaat ttcgaaagag 1099861 cgctatcaga attgggattg gaactacggc cgctcaccaa aatttaacct taatcattcg 1099921 aagcgttatc cggttggatc gatcgatttg cacctggaag tcaagaaagg caaaatcgag 1099981 gactgcaaaa tcttcggaga tttcttcggt gtcggtgatg tatctgaaat tgaaaacctg 1100041 ctggtcggaa aacaatacga acgcagcgtc atcgctgatg tgctcgaagg tgtgaatctc 1100101 aagcattact ttgggaacat tacgaaagag gatttccttg atctgattta ctaaggcaaa 1100161 acacatcgtt tgaaagagcg gttgtgtttt tgaaataatg gaggcaggag ggattcacat 1100221 gaaagtgttt ttaatcggag cgaacggaca aatcgggcaa agactcgtct ctttattcca 1100281 agataatcct gatcattcca tcagagcgat ggtcagaaaa gaagaacaga aagcgtctct 1100341 tgaagctgcc ggtgcagaag ctgtgcttgc gaatctggag ggcagcccgg aagaaatcgc 1100401 cgctgcggca aaaggttgtg acgcgatcat tttcacagcc ggttccggcg gcagcacagg 1100461 ctatgataaa acgctgctgg tggatcttga tggagcggca aaagccattg aagctgcggc 1100521 cattgccgga atcaaacggt ttattatggt cagcgccctg caagcccata accgtgaaaa 1100581 ttggaatgag gcactcaagc cttattatgt ggccaagcat tatgctgata aaattctgga 1100641 agcgagcggt ttaacctata cgattatccg tccgggaggc cttcgcaatg agcctggaac 1100701 gggaactgtt tcagcagcga aggatctgga gcggggattt atttcccgtg atgacgttgc 1100761 aaaaacggtc attgcctctt tagatgagaa gaatacggaa aatcgggcct ttgatctgac 1100821 agaaggagat acgccgattg ccgaagcatt gaagaaacta tgacagtact gacactcagg 1100881 gctttttgct cttgagtgtt tttttctgtt tctctataat ggagaagaaa gcttggcttc 1100941 aataatgaat gactattcat tcacttaagg ggtgggagaa tgaatcttgt ttcaaaattg 1101001 gaagaaacag catctgagaa gcccgacagc atcgcatgca ggtttaaaga tcacatgatg 1101061 acgtatcaag agctgaatga atatattcag cgatttgcgg acggccttca ggaagccggt 1101121 atggagaaag gggaccattt agctttgctg cttggcaatt cgcctgattt tatcatcgcg 1101181 ttttttggcg ctttaaaagc tgggatcgta gttgttccca tcaatccgtt gtacacgccg 1101241 acagaaattg gttatatgct gacaaatggc gatgtaaagg caatcgtggg cgttagccag 1101301 cttttgccgc tttatgagag catgcatgaa tcgctgccaa aggttgagct cgtcatttta 1101361 tgccagacgg gggaggccga gccggaagct gcggacccag aggtcaggat gaaaatgaca 1101421 acgtttgcaa aaatattgcg gccgacatct gccgctaaac aaaaccaaga acctgtacct 1101481 gatgataccg cggttatttt atatacgtca ggaacgactg gaaaaccgaa aggcgcgatg 1101541 ctgacacatc agaatttgta cagcaatgcc aacgatgtcg caggctattt gggaatggat 1101601 gagagggaca atgtggtctg cgctcttccc atgtttcacg tgttttgttt aaccgtctgt 1101661 atgaatgcac cgctgatgag cggcgcaact gtattgattg agcctcaatt cagtccggca 1101721 tctgttttta agcttgttaa gcagcagcag gcgaccattt ttgccggtgt gcctacaatg 1101781 tataactact tgtttcagca tgaaaacgga aagaaagatg atttttcttc gatccggctg 1101841 tgcatttcgg gaggcgcgtc catgccagtc gcgttgctga cggcgtttga agaaaaattc 1101901 ggtgttacca ttttggaagg ctacgggctc tcggaagcat cacccgtcac gtgctttaac 1101961 ccgtttgaca ggggcagaaa gccgggctcc atcgggacaa gtatcttaca tgtcgaaaac 1102021 aaggtcgtag atccgctcgg acgcgagctg cccgctcacc aggtcggcga attgatcgtg 1102081 aaaggcccca atgtgatgaa gggctattat aaaatgccga tggaaacaga gcatgcatta 1102141 aaagacgggt ggctttatac gggggacttg gcaagacggg atgaggacgg ctatttttac 1102201 attgttgacc ggaaaaaaga catgatcatt gtaggaggat acaatgtgta tccgcgggag 1102261 gtggaggagg tgctgtacag ccatccggac gtcaaggagg cggttgtcat cggcgtgccg 1102321 gacccccaaa gcggggaagc ggtaaaggga tatgtggtgc cgaaacgctc tggggtaaca 1102381 gaggaggaca tcatgcagca ctgcgaaaag catctggcaa aatacaagcg gcctgccgcc 1102441 attacgtttc ttgacgatat tccgaaaaat gcgacgggga aaatgctcag acgggcactg 1102501 agagatattt tgccccaata aaatgaaaaa gcgaagcggt tagcttcgct ttttcatttt 1102561 caatcctttg cttctttttt aataatattt agcagcgcct ttgtatcatt tttgcttaat 1102621 ttgtagtatg tgccatcctt caaaaaaacg gcttgctggc tgccgtcaat ccatagtctg 1102681 aatgagtcat accggtcttt atgaaacttg attgtccctt cgtaatcagg ggctgatgtt 1102741 ttttctgtct tcacctgttt tccctgattc ataatatcca gcatatcttt gacgtgctgt 1102801 cttttttcaa tctcgatatc ttcctggccg cttgaagaca gtgtgatcaa atccgcgtct 1102861 accgattgat acacatcgcc tgatcggctg taaagataaa aaaatgcgat aaacacaaga 1102921 ccgattacca cgatggctgc cactattttt ttcatttgca tcactccaaa cattgttagt 1102981 tttcccagcg atcggggttt ccatgcttaa aagggtggaa aagtgcggaa cacagcttgg 1103041 ttctaagaat ttgaatttat gattacaata gaagtaacgg gttgatgtga ggagtgaggc 1103101 gttatgcgca agtggattgc ggcagcagga cttgcttacg tgctgtacgg gctgtttttt 1103161 tattggtatt ttttcctgtc gggtgattcc gcaataccgg aagccgtgaa agggacgcag 1103221 gctgatccgg cttctttcat gaagccgtct gagttggcag tggccgagca gtattcgaat 1103281 gtcaagaatt ttttattttt tatcggggta ccacttgatt ggtttctgtt ttttgttctg 1103341 cttgtcagcg gtgtttcaaa gaaaatcaag aaatggatcg aagcggccgt gccttttcgg 1103401 tttttgcaga ccgttggttt tgtgtttgtg ctttcgctga ttacaacatt ggtgacgctg 1103461 cctttagatt ggataggcta tcaagtatcg cttgactata acatttccac acagacaacg 1103521 gccagctggg ctaaggatca ggttatcagc ttttggatca gctttccaat ctttacgctt 1103581 tgcgttctcg ttttttattg gctgatcaaa aggcatgaaa aaaaatggtg gttatacgcc 1103641 tggctgttaa cagtgccgtt ttcgctgttt ctgtttttta ttcagccggt cattatcgat 1103701 cctttataca atgattttta tccgctgaaa aacaaagagc ttgaaagcaa aattttagag 1103761 ctggcagatg aagccaatat tccggctgac catgtatatg aagtgaacat gtcagaaaaa 1103821 acaaatgcgc tgaatgccta tgttacagga attggggcca ataaacggat tgtattgtgg 1103881 gatacgacgc tgaacaaact tgacgattca gaaattctgt ttattatggg ccacgaaatg 1103941 ggccattatg tcatgaagca cgtttacatc ggtctggctg gctatttgct cgtgtcgctc 1104001 gccggatttt atgtcattga taagctttac aagcggacgg ttcgcctaac ccgcagcatg 1104061 tttcatttag aagggcggca tgatcttgcg gcacttccgc tgttattgct tttgttttct 1104121 gttttgagct ttgcggttac gcctttttct aatgctgtct cgcgttatca ggagaataag 1104181 gctgaccagt atgggatcga gttgacagag aacagagaag ccgctgttaa aacgtttcag 1104241 gatttggccg tgacggggct gagccaggtt gatcctccgg tgcttgtgaa gattttcaga 1104301 ggcagccatc cgtcgatcat ggaacggatt caacatgcgg agaaagaaga gaatgcgccg 1104361 gaacatcagg atgctgacaa ataaaaagaa gcaggtatgg aggaacctgc ttctttttac 1104421 tattattgtg cagctgcttg tacgttgatt aacccttttc catagtagaa agagtttcca 1104481 agatatgttg cagtgctttc taaacgatca cggacttgcg cgtttgtcca agtcgggtgc 1104541 ttagaaagaa ttaacgctgc tgctccggca acgtgaggag tcgccatgga cgttccgtta 1104601 taagcgccgt aagtgcctcc aggaagtgtg ctttggatgg acacgccagg agccatcaca 1104661 tcaagctcag aacctgcgct ggagaatgaa gctctttggt tgctgctgtt taccgcacct 1104721 actgcaatag tagaaggata ttttgcaggg tagccgactg tgcttgtgct tccggatgaa 1104781 ccttcgtttc cggctgcggc agcaacgacg ataccgctgg aaacggcttt gtcaacgact 1104841 gttttcagcg ctgtagaacc agtaggtccg ccaaggctca tgttgataac atccatattg 1104901 ttggaaatgg cccactcaat gccgttaata atccagctat attggccgct tcctgttgaa 1104961 tcaagcactt ttactgcata taatgatgcg cttggcgcta cgcccagaac accgattgag 1105021 ttattaagag cggcaatcgt accggctaca tgcgtaccgt gagaactgcc gtcctggtat 1105081 gggtttgttt cagaaggtac gaagcttgct ccgcctctga cgtttaagtc aggatgagaa 1105141 gagtcaattc cgctgtcgat aacagctact tttacgttag agcctgtgta gccttgagag 1105201 tgaagagccg gcgctttaat ttgagaaatg ccataaggaa cagattgcgc atattcatgt 1105261 gcaatatgat cttcttccac atatgcaacg ctcggatctt ttttcaattc ttttacagct 1105321 ttttcatcca atgttgctgc ggccgcgtta acatacttaa attgcttttg aacctttccg 1105381 cctttttcag aaataacatc ctttttcttg gcggaactca tggcactcat tgtctgttta 1105441 aatccgacaa tgtatttctt ttctgtactg ctttttccgg cagcctgcgc agacatgttg 1105501 ctgaacgcca tcgtaaagat taacgttaac gcaaacaaca agctgatcca caattttttg 1105561 cttctcactc tttaccctct ccttttaaaa aaattcagag tagacttact taaaagacta 1105621 ttctgtgaat ttattgtaat agatggaata atattttagt agacccattt ttttgagatg 1105681 attttatctc tatttaggta tatcatctct cgctatttcc gtagagactc gaaataacta 1105741 ttttcataca gaaaagaacg aaaatagaca tgagtaaatg ttcattatgc tgaaatgtca 1105801 tgctttttta ggttaaatgc tcctgagtcc cggcaaattc ctgtcgaaaa aattcgttca 1105861 aatgacctgc gtgtgcttcc gtgagaacaa tggatattat cgtgatattt tttcaaagca 1105921 tgatgataaa agtattctga aaaataaact ttacagaaaa gggatagaat gaaaaaatta 1105981 ttgagaggga ggaagaaata agatgaacat tcgccaagca aagacatcag atgcggccgc 1106041 cattgcgccg ctgtttaacc aatatcggga attttataga caggcatccg atttgcaagg 1106101 ggcagaggct tttttgaaag ctcgtttgga aaatcacgag tctgttattt tgatagcaga 1106161 agaaaatgga gaattcatag gctttaccca gctctatcca acgttttctt ctgtgtcaat 1106221 gaaaaggata tacatattaa atgacttatt tgtcgttcct catgcgcgta caaagggagc 1106281 cggcggccgg ctgctttctg ccgcaaagga ttatgcaggg caaaacgggg caaaatgttt 1106341 aacacttcag actgagcacc acaaccggaa ggcaagaagc ttgtatgagc aaaacggcta 1106401 tgaagaggat accggatttg tccattattg tctcaatgtg ccggcgaagt gaaaatggcg 1106461 gcttgatgat ttggtttttt gaacgttctt cggttacgat ataaatgaaa aggagtgtgc 1106521 cgaatgtcaa cgttatttca agccttgcag gcagaaaaaa atgccgatga tgtttcagtc 1106581 catgtgaaaa ccatatcaac agaggatttg ccgaaggatg gtgtcctgat taaagttgct 1106641 tattccggca ttaattacaa agatggtctg gccggaaaag caggaggcaa tatcgtcaga 1106701 gagtatccgc ttattttagg cattgatgct gcgggtacgg tcgtctcttc caatgatccg 1106761 cgttttgcgg agggggatga ggtgatcgcg acaagctatg agctcggtgt ctcacgtgat 1106821 ggcggattaa gtgaatacgc ttcggtgcct ggtgactggc tggtgccttt gccacagaat 1106881 ctttcgttaa aagaagcgat ggtgtacgga acggcgggat ttactgcggc gttatcagtg 1106941 catcggcttg aacagaacgg tctgtctccg gaaaaaggca gcgtgctagt cacaggagca 1107001 accggcggtg tcggcggaat tgcggtatcg atgctgaaca agcggggtta tgatgtggtg 1107061 gcaagtaccg gaaaccggga ggcggctgat tatttgaaac agcttggtgc aagcgaagta 1107121 atcagcaggg aagatgtcta tgacggaacg cttaaggcgc tgtccaagca gcaatggcag 1107181 ggagcggttg atccagtcgg cggaaaacag cttgcctcgc ttttaagcaa aattcaatac 1107241 ggcggatctg tcgcagtgag cggcttaacc ggcggaggag aagttccggc aaccgtgtat 1107301 ccttttattc ttcgcggagt aagcctgctc ggaatcgatt cagtatattg tccgatggac 1107361 gtcagagccg ctgtttggga gcgcatgtct tctgatctca agcctgatca gctgctgacc 1107421 atcgtggaca gggaagtatc attggaagaa acgccgggtg cgttaaaaga tattttgcaa 1107481 aatcgcattc aaggaagagt gattgtgaag ctttaacagg atcagcttgc agagaatgtt 1107541 atttttctgc aagctttttt gtggacagga tgatcagctg ctgaactgct gtgtcgcgaa 1107601 acaagatttt cctgtaagcc gaactttctc ttctcatttt aaaaataatt ggtgataatg 1107661 attctcattc cgtgttatac tactcttgga catcttaacc atagaaacta ccaacaggag 1107721 agactggaac atatgaaaaa aacactgatt attcttacag ttttacttct ttctgtctta 1107781 acggctgctt gctcgtcttc aagcggcaat caaaacagta aagaacataa agtggcggta 1107841 acacatgatt tagggaagac aaatgtgcct gagcatccga agcgggttgt tgttcttgag 1107901 ctaggtttta ttgatacact gcttgatctc ggcattacgc ctgtcggggt tgccgatgac 1107961 aacaaagcga agcagctgat caacaaggat gtgctgaaga aaattgacgg ctacacatct 1108021 gtcggcactc gctcacagcc aagcatggaa aaaatcgctt cattaaaacc cgatttaatt 1108081 attgctgaca cgacccggca taagaaggtg tacgatcagc tgaaaaaaat agcgccgacg 1108141 attgcactta ataatttaaa tgctgattat caggatacaa ttgacgcttc gcttacgatt 1108201 gcaaaagcag tcggcaagga gaaggaaatg gagaaaaagc tgacggcgca tgaagaaaag 1108261 cttagcgaga caaagcagaa aatcagcgcg aacagccagt ccgtgctttt gatcggaaat 1108321 acaaatgata ccattatggc cagggatgaa aacttcttta catcgagact tttaacacag 1108381 gtcggctacc gatatgcaat cagtacgtca ggcaatagcg attcaagcaa tggcggcgac 1108441 tctgtgaata tgaaaatgac actggagcag ctgctgaaaa cagatccgga tgtgatcatc 1108501 ctgatgacag gaaaaacaga tgacctcgac gccgacggta aacgcccgat cgaaaagaat 1108561 gtcctttgga aaaaactgaa ggcagtgaaa aacgggcatg tataccacgt ggatcgtgcg 1108621 gtgtggtctc tgcgccgcag tgtagacggg gcgaatgcca ttttggacga gcttcaaaaa 1108681 gagatgccgg ctgctaagaa ataaaagaaa agacaggcaa acgcctgtct ttttcttatt 1108741 tgataaagcc ggataagtgg ctgttgatat tatagtcttt tatccgccat ttttcttctg 1108801 caaattcaat gttgctgagg caggcgttga cgagacgggt gctttgaagc tccgggtcac 1108861 cgccggatat ttctgtcagc agggcgtgaa ttgccgcacc gtgcgccacg atcagcacct 1108921 tcttgtttgg atacgcctga ttcacttttg ccaaaccgcc catcagcctg tcagtgagtt 1108981 cttctaaggt ttccatattc ggatagatgt tatctggata gcgctttgtc cgttcctcca 1109041 gcggcatgcc ctccgcgtcg ccgtaatcgc gttccttaaa atcatccatc tcgactatcg 1109101 gaagatgcag atattcatta ataatttccg cggttctttt cgctcttttc agcgggctcg 1109161 tcacaataat atcccaagaa aagtccttta catattctcc ggtttctctt gcttggcgtt 1109221 cacctgttgc gtttagcggg atatcggttt tgccttggca tttttgctgc aggttccaat 1109281 cggtttctcc atgtcttact aaacaaacgg ctgtcataaa atccccttcc tgactttatt 1109341 catatcgcta ttatactaaa tcgaaagcgt gtgtcctatg aaaaagccta tgcaagaact 1109401 tcaaataata aagccagtcc gattccgccg ccgcttccga tggctgcaac agcatattga 1109461 cagtctggcc gtcttttcgc ttcataaaac aatctggtta ccagagctgc acctgatgca 1109521 ccgtacggat ggccaagagc taaggcgccg ccgcgcacat tgatttttga aaagggaatg 1109581 ccgagttctt gcgagcagac acaaattttg acggcaaagg cttcattgat ttcaaataaa 1109641 tcgatatcat caggtgttac atcgtgtgta tgtaagagct gacgaatcgc gacaaccggt 1109701 gccgcgggcg gaaagttggg gtgaatgccg ctgacagcgc tgccgataaa ccgaagcaca 1109761 ggcttaagtc ccagggctgc tgctttttct tcttccatta ccaaaagagc ggctgctccg 1109821 tctgctatgc cactgctgtt ggctgctgtg actgttccgg agctggtgtc gaaaaccggc 1109881 tttgcacggg gaataatcgc ttctattggc cgcgttttca aaaatgcttc gtccgtctcc 1109941 aattccccga gagcaacaac ttcttcacgg taaaatcctt catcatgcgc gttcctgctg 1110001 cgttgatggc tgagaagcgc gtactcatcc tgcatgcttc tgctgatgga atagcgtgca 1110061 gccgtatatt ctgccgcaat gcccatgtct ggatcgccga tcgcatctgg agaaaagcga 1110121 gcccgttctg aaaaagggga ttggctgctg ctttctgagc cgcccgcgat atacatcgtg 1110181 ccggctcccg cttgaataag gctgcaggca tagcgcacag cttcaaggcc ggagccgcac 1110241 tgtctgtcaa ttgtcattcc gggaaccgat aaaggcagtc cggcttgaag ggctgacagt 1110301 ctggccaggt tgccgcctct gccagtagcg tttccgagaa tgacctcgtc aacttgatcc 1110361 tctagctttc ggctgagaca gcggatgatg ggagccgcca aatcctccgg caggaagggc 1110421 ttcagcagtc cgttttgatt tccaaagatc gttcgttttg catcaacaat aaccgcattc 1110481 atttatactg tacactctct tccagccatt ttttcactct ggaacgggca atttttccgc 1110541 tgctcgtttc cggcaagctg tctgcaaaca cccatttttt cggaatttta taggaggcta 1110601 atttctgttt acaccaggct ttcagtgttc tggcattagc gtttccaaga atgacagcta 1110661 cagcgatttc tccccaatac tcgtcgggaa tgccaacgac agccgcgctt tcaacctctg 1110721 ggcaggcgag aagcacacgt tcaatttctt ctgggaaaat atttaatcct ccgtacacga 1110781 tcatcccgtt ttctcttcct gatatgtata gaaagccctc ttcatcaacg tagcccatat 1110841 catctactgt catccattca tctggtgtgc tgccgttcac atagccggaa aacctcatcg 1110901 ggcttttgac aaatattttt ccgatttctc ctggctggca gcgttctcct ccagcgttgc 1110961 ggatttcgat ccggacatta tgaaaagggc ggcccgctga atgcggcttc cgtttgctgt 1111021 cttccggtga agaaaacgtc acaaaactaa gctctgatgt gccgtaaaaa tcgtacagct 1111081 tgagatgagg ccatgcagcg gcaagcttct tcttggattc tgccggccag tctgcgccgg 1111141 atgaaatgat tttgacggga ctgtcgggaa aaccctcaat ccttgcgagg gcgtctgtca 1111201 tcgtcggtac ggtatagaga acactgatgg attcacggca cagccattcc ttcgctttgg 1111261 caggagaaaa ctttttcagc aaacaaacgg ttcctccgag aaacaaagtg ctgacagccc 1111321 catataggaa gtgagaggac attaacgctc cgggaatcag aaccttatca tctgatgaaa 1111381 tcgaaaaatc tgtttctgta caggtaaagc tctccatcca tgagcggtga gatcgcgtaa 1111441 aggccttcgg ttttcctgtc gagcccgacg taaatcccat ataaaaaggg tgctccggat 1111501 caatggtagg caagggatca gcggctgcct cagaaatatc tgccatacag ttatccagca 1111561 atacaacagg tgtctggcta tctgtcagtt tgtttttgaa aaaggctaaa gtaaccacaa 1111621 gatccgcatt gcttatggac agccgctcct tacattcagc cgggctccag cgtgtgtcga 1111681 tgggaatggc cgtacatcca gccgctgcgg ctccggcaaa cagctgtaaa aacgcgagac 1111741 tatttgggag caggatcgcc acacgattcg gcatgctcgg ctgtgaccgc agccaatttg 1111801 cggtttgaga gacaagccga tcccaatcat ggtacgtgat ttgctccgat tcagtctgga 1111861 tcgctacacg gccgggcgat gtttcggcag tagatgaata ggtatgagta attgtcatgt 1111921 attgtcatcc tccttttgta aacatcgtat cagaaagaga caaggcttga gtgattttta 1111981 tcgccagaaa tgcagataca gccgctttta tcaaatcacc aggcacatat gcaaggctca 1112041 tgaaggcggc ctgtgacaaa tcaatatgca tgataaaagc ttgtaccggt ataccaagca 1112101 gataaataaa gatgatgccg aatacgatat gagtgaaaaa gagacgcaat actgtcacct 1112161 tccgcagcct gttagcggct aaactgatca gccatgaagc gaggggataa gcaatcaaaa 1112221 agcctgcgct cggtccgaaa aacacaccaa aaccgcctcg tccgccgggc aacagcggcg 1112281 ctccgaaggc gacgagcagc aaaaagacaa gctggcttaa gaaagcagac tttggcctga 1112341 gaatgctgcc tgccaacatg acaccaagcg tttgcaatgt aatcggaacg ggtgtaaagg 1112401 ataagaagag agggggcata aagccgagca ctgccatcag cgcggtgaaa atcgcaatat 1112461 gcatcatgtc gattaatttc agcatgtgaa atcctccaaa aagtaatcaa atatggttat 1112521 acaataaatg caggtaatta ttatgtcaac tgatttttaa tttaagttta cataatgaac 1112581 gcaaaaaaac cggccgtatg gcagaccggt ttttgatggt tattcttctg tcaggatgac 1112641 aagcgaatca acggaagcgg ccacatggga aacggcgcgg ctgacttcct gaagccctcc 1112701 aagaaaggct tgcagatcga cgtcgatttt gcctgattgc tctttgctga ttttcatgct 1112761 gtggacgatt tcatcgaata agcggttaat ttgcgtcatt ttttctttac tttcgctgac 1112821 tagctcattc acgtctttga tatgcttgga tacaatgttg atttgtgtat tcgtattgtt 1112881 cacaagctca gaaacagtag agacggtttt tttcgtatcc tcagaaagct tccgcacttc 1112941 atttgccacg acagcaaagc ctttgccgtg ttctccggcg cgggcggatt caatagatgc 1113001 attgagcgag agaaggtttg tttgttcagc tatgcctgtg acgatgccga agattttttc 1113061 aatttgctgc gcgatttcat ccagcttgac catttctttt tcgatttgga caaggcttgt 1113121 gtcaattttg ttcatctgtt tttgctggac ttctagctct ttttttccgc cgatcgactt 1113181 ttcttcaaca gtgctggatg ttacagtgcc ggctttggat gcttgagaaa tgccttcaga 1113241 tttgtccaca agctcttgaa ctgatctgct tgtttctgaa aacagattgg caatcgatcc 1113301 agaggtttct tgaattttct gatgaagaag gtttttcttt tcttcttgtt catcacgggt 1113361 ctggttgtac tcgctttgaa acgcttcaag gacaagctgc tgttctaagt tcaagatttt 1113421 tgttgttgct ttaatggctt ttagcagttc ttgctgattt gtaatggacg cttcataaat 1113481 gtcaatcatt gacaaaagga gctcttgaaa cgcacccata taccattttg gcaaaaggcc 1113541 gattcttaaa tggatggagg cgattcggtt acgcttttca ataaattcat catcgataac 1113601 gcctgcaaac atttcctgaa tatgccgttt taacgtttgt tttaagcggt caactgagct 1113661 gtgatcatta atgatatcca tcaatgagct ttcatggtca aggtttttat aaaacgcatc 1113721 gacgatattt acgatatttt cttgaatgag tggctgaagc tgctctaaca cataaagctc 1113781 agcatctccc aacctgacca ttttgagctg ttttttgaca tctgcatgtt tgtttgtgag 1113841 ctgaatgcgg tttttttgtt gtccgtttga atctgaaaag taagctgttt cttgttttct 1113901 gtctttttta aataacaata caatgatccc ccttgggaaa aatataattt ttactttttg 1113961 gctttttaag cctttttctt ttttatcggc caagggaaac atgaatgaag ctgcagatga 1114021 aaaatatttg aaaaaacgtt cattaaaatg aacggtttaa tcgagatcta tttgttttaa 1114081 tggtttaatg gccggaccct ctacaacttc gccagatggc ttaaagcgtg atccgtggca 1114141 cggacaatcc cacgtatgct cactgtcgtt ccactcgacc tcgcagccta aatgggtaca 1114201 agtcgtatca acgagatgga ggcagcctgt ctcatcacga aatgctcccg ctcgcctgcc 1114261 gtttatggtg acggctttcc cttctcctgg cgaaatgtct tcaaattgga catcaggctt 1114321 ttcaagcttt ccttttatca aatgcttggc gacatctgca ttgtaggaaa tcactttctg 1114381 caacccggga ttcagatgga aacgggacgg cgtgaaaatg ctttcgtatg ggttttcttt 1114441 tttctccaca aggtctgaca ataaagtggc tgcgactgct gaggacgtca tgccccattt 1114501 tttgaacccg gtcgctacta gaatattgtc ctcattttcc gacatcggcc cgataaacgg 1114561 gattttgtcg atcgtcacta gatcttgggt ggaccaataa tatggaatgc tttcgatgcc 1114621 gatggtgctt tcggccagtt gtctcagtgt ttcataatgt gtagacatgg cttttccctg 1114681 gcctgtttta tggcttactc cgctgaagag aatcagcttt tcaccgttta caaccgtata 1114741 gcggagcgcc actgacggct gatcgatact caaatacatg ccctcgggat actcgatctt 1114801 cggcttgatg gcaaggacat aagatctgtc ggagtacatt ctcgcagcat ataatccgcc 1114861 tccgtcataa aaagggaagt gggaacagca tatgataaag cggctcttaa tggcgtgccg 1114921 gctttttgtt accacttcgg gcctttcgcc ttttttgata tcaagcgcaa cggtctcttc 1114981 ataaattcgg ccgccttttt gaacaatttg ctccagaagc gcttttaagt attgaagcgg 1115041 atgaaattga gcttgattct tcatgacaag cgccagctta gaacctaagg gaattggaag 1115101 atccttgata aggtctcttt caattccgag ctttgtgtat gcctcatgct cggtgtggat 1115161 tttttgaaca gcgttttcat ttgccgtata aagatatgcg tcttgctcga tccattcaca 1115221 atcaatttga tgttcatcca caatgccttt tatgtaatca attgcgtttt ggtttgcttc 1115281 ataataaagc ctcgcatggt ttaatccgaa atggcggata aattcgtcgt atatcatgtc 1115341 atgctgtgcg gtaactttag cagttgtatg cgcagtggtt ccgttaagaa cctgatttgc 1115401 ttcaatcaaa acgacacgga agcctctctt cgtaagttca tatgccgttg tgattcccgt 1115461 aatcccgcct ccgataatgg tgacgtcaca ttcagtgtcc tcttgaagcg caggaaaaga 1115521 aggcaggtca gttgatgttt tccagtatgt ttcaggtgct tcctttgcaa aatgttgatt 1115581 agccaagccg ttatacctcc aatcagattt attcttaatt tttccatatt ctatcttttc 1115641 atacatagga agcaggcatt gttcataaca taataaggtt gaaaaggagt gatttcattg 1115701 gcgaatcaaa aaaagaaaac attaccgcct cagcaccaga accagcagcc tggttttgaa 1115761 tatctgatgg acccgcgtcc ggtttttgat aagccgaaga aagcgaaaaa attagagggc 1115821 aaaaccgcta ttattactgg aggagacagc gggattggac gcgctgtctc ggtgttattc 1115881 gcaaaagaag gggctaatgt ggtcattgtg tatttgaatg aacatcagga cgccgaggaa 1115941 acaaagcagt atgtagaaaa ggaaggggta aaatgcctgc tgattgcagg agatgtcggg 1116001 gatgaagcgt tttgcaatga tgtggtcggg caggcaagcc aagtgtttcc atccattgat 1116061 atattggtta acaatgcagc tgagcagcat gtccagccca gcattgaaaa aatcaccagc 1116121 caccagctga tcagaacctt ccaaacaaac attttttcca tgttttactt aacaaaggca 1116181 gtgctgcctc atttaaaaaa agggagctct attattaata ccgcttcaat taccgcctat 1116241 aaaggcaata aaacgctgat cgattattca gcgacaaaag gcgcgatcgt tacgtttaca 1116301 aggtcccttt cccagtcgct tgttcagcag ggcatacggg tcaatgcagt ggcaccgggt 1116361 cccatttgga caccgcttat cccggccagc tttgccgcaa aagacgtgga agtgtttggt 1116421 tcagacgtgc cgatggaacg cccggggcag ccggtcgaag tggcgccaag ctatctatac 1116481 cttgccagcg acgattccac atacgtcaca gggcagacga ttcacgtcaa tggcggaaca 1116541 attgtgaacg gataataaaa agccaatcct tgaaggattg gcttattcgc tctgcttgag 1116601 cgctgcatat tctttagaga gcgtaagaaa cgcatcttta tctttttcgt ccaaggcttt 1116661 gttaatttgg tccgtcagca tggcaagccg acggttatac aaggattcat cgagcaccat 1116721 ttgaatgtaa atatccgtca ttgtgacatc gaattctttt gttttttgcg tgttgcggga 1116781 cttcatgagc tcagtgtacg attttttctc tttcataaag aatcccccca atgccttttt 1116841 tatagtatat ggataacggt cgaaaaaatc aataaatttt tataattttt agacaactaa 1116901 tacttggcaa tctatcgaca tatcctgcaa aatgccgtaa accggcaagt cttatgaaag 1116961 taaaatcggt ttattactag tcatttagta ccattaaata tcattaaaag atgattttat 1117021 cttaaatgtt aaaaaaacct gtcgttttac aaaaacagat gatagattat tagtataaat 1117081 tttgcagaaa aaggatggag gccataatat gagtcagaaa acagacgcac ctttagaatc 1117141 gtatgaagtg aacggcgcaa caattgccgt gctgccagaa gaaatagacg gcaaaatctg 1117201 ttccaaaatt attgaaaaag attgcgtgtt ttatgtaaac atgaagccgc tgcaaattgt 1117261 cgacagaagc tgccgatttt ttggatcaag ctatgcggga agaaaagcag gaacttatga 1117321 agtgacaaaa atttcacaca agccgccgat catggtggac ccttcgaacc aaatcttttt 1117381 attccctaca ctttcttcga caagacccca atgcggctgg atttcccatg tgcatgtaaa 1117441 agaattcaaa gcgactgaat tcgacgatac ggaagtgacg ttttccaatg ggaaaacgat 1117501 ggagctgccg atctcttata attcgttcga gaaccaggta taccgaacag cgtggctcag 1117561 aaccaaattc caagacagaa tcgaccaccg cgtgccgaaa agacaggaat ttatgctgta 1117621 cccgaaagaa gagcggacga agatgattta tgattttatt ttgcgtgagc tcggggaacg 1117681 gtattagaaa aataggaagg agctgaccga acagggcagc tcctttcata aagctatgcc 1117741 gtcggaattc ctccggtgat gccatatacc tgagatgtca catagcttga attctctgaa 1117801 gctagaaata cataaacatc ggccaattcc actggctgcc cagcgcgatt taatggagct 1117861 ggcggcgtgc cttgtccgaa tttcgggatg ttttccgtcg gctgtccgcc ggaaatttgc 1117921 agcggtgtcc aaattggtcc gggcgcaact gaatttactc tgatgccttt ggaagcaagc 1117981 tgttttccca gtccgacggt aaagccgata atggcgtttt tcgttgctgc gtaatctaac 1118041 agcatcgggc ttggattata gccttcaact gaggtagttg tgataattga agctccctcc 1118101 ggcaaatacg gaagcgccgc ttttacaacc cagtaaaggg aaaagacgtt cacttcaaat 1118161 gttttataga tttgttcagt aggcagatct tcgatgtttt cgaccgcttg ctgtttgcct 1118221 gcaacgagcg ctagcacatc aagtccgccg agttcgtgat gcgactgttt gactagatct 1118281 tggcaaaagg attcgtcgct caagtctccg gggatcagca ctgcttttcg gccttctgct 1118341 tcaatcagct cttttacctc ttcagcatct ggctgttcct cgggcaagta gttaatagcc 1118401 acatcggcac cttctctggc gtaagcaatt gcggcagcgc ggccgatacc ggaatcgccg 1118461 cccgtgacaa gcgcttttcg acccgttagt ttacctgatc ctttgtagct tttttctccg 1118521 caatcaggga caggcttcat gttcttttgc aggcctggcg gttcttgata ttgttcggga 1118581 aattcatcat gaaaaaatgc ttttatagga ttcgtaagat ttgaatcaga catcagcaac 1118641 gctccttttc tgtttggtgt acattcgtat gtgtacccct gagcataagc agaaaaacat 1118701 gttttggcag tttgaatagt gaaggaaaaa gaaaacaaga aaaaacaaag ccttcttcca 1118761 tatttatctt gtcaaataag actatatgaa ttatgataaa ttcgagctat aaatcaacta 1118821 aatattgggt gttgggagag tgaatcgtca tgaaaaaagc ggcggcggtt ttgctgtcac 1118881 tcggtctcgt tttcggtttt tcatacggag ctggccatgt ggcggaagcc aaaacaaagg 1118941 tgaaggtcta taagaactgc aaggagctaa acaaagtata caaaggcgga gtggcccgca 1119001 catcgaaggt gaaaaacaaa ggcggaaaaa cgaagtacaa gccttacgtt tctaaggcac 1119061 tttacgatgc caataaaaac aaagaccgcg ataaagatct tatcgcctgt gaacggtaaa 1119121 taagaaaaag caatctggtg tccagattgc tttttttatg cttaggccgc ctgatcggcc 1119181 gcagcgcttt tcgccttcct tgtcataagg ctgactgcca tcatgaccgt gatattcaaa 1119241 agcagggcga cgatgccgac attcaagtct tttgcggctt gcggcagagc cggaaataaa 1119301 gtgccgatcg tcgtttccgt cattgtaata taagtaactg ctccgacacc tgcaataatg 1119361 ccggcgaaag ctccttgctt tgtcaccata ttatgcttga gcaggctgaa caaaagggcg 1119421 gggaatagct gtgtgacaag gctgtagccc atcaaaagca gcgtaacgat ggtattcccg 1119481 cctttgaagg taaaatacac cgaaatcagc gcaatcaccg gcactaaaaa cttagcaagc 1119541 gccgatactt gctgttctgt cgtgcggggc gcgattacct tgtacacatt ttttgcaaac 1119601 agtgtggagg cggacattaa gatcatagac cctggcacaa gtgctgtcag cagtccggca 1119661 gcaccgataa ttccgacaaa ccaagggtca aatgcttgca gagacagtct caaaagcgac 1119721 aaatccccgt ctgcgccatt cagatctgga acttgcagga tagccgcaaa gccgacgaaa 1119781 aggacgaaga gcaggaccag ctggtacaaa ggcatgatga tggcgttttt acgaaacact 1119841 tttgggtttt cggctgaata cgaagcggaa aacgtgtgag gccacatgta aaaaccaagc 1119901 gctgtcaaga gtacggttga actgaaccag gccacacttt gtcccgattc ggggagcgta 1119961 agaaagccag gctttgccgt ttcaatctgc tgaaacatgt cttgaaatcc gccgtagtaa 1120021 tgaattggca aatacacacc taaaaacaga acgacaacca gaatcatgat gtccttcaca 1120081 accgatatcc aggcagaccc gtgaatgcct gaaaccataa cataaaccgt gatggaaaca 1120141 gcgccgatcc agatggcagc ggtcggggtg attttgccgt acgaggtttc cgatacaatc 1120201 agcccgaggc ctttcagctg cagtacaaga tagggaatga gtgcggcgat gccgaccagt 1120261 gaaacgagaa tgccaagcag cggactgttg tatttttttg tgaaaaaatc agactgcgac 1120321 atcagtttat gctgtttcgc gtacgtccaa actgctggaa gaagccagta agaaaggatg 1120381 taggccagac atccgtaggc gatgatataa aaggctggac cgccttttcc gtaggcccag 1120441 ccgctgccgc cgagaaacgt aaaagtagta taaatttcgc ctgccatcaa aaggaagacg 1120501 aaaacagttc cgaagccgcg ccctccgacc gtccactgct ccaggttcat gtcttttcct 1120561 ttttgggcgc gtataccgag aaaaatactc aagagcagga caccgaagat gatgatgaga 1120621 gctgcattca ttctgcttcc tcctttttat tttccttgtc gaggacatac acaatcgcca 1120681 tcagcgcaga ggtcaaaaga gcccacatca caatataggc aagaataaac ggcatgccga 1120741 acacataggg ggtcacctta tttgcaaaag ggatgccgag taagattccg ataaagggta 1120801 aagcggcaag aacgtgaatc agtttcatag aatcctcctt ctatttagga ttgaggtgta 1120861 caagcctaag cgtactgaaa atgatgtcgc agatatcgca gcacatgtca ttttttggag 1120921 tgaaaggctg tggttcgaat tataaataaa tttattttgt ttgtatagtg tgaattgtct 1120981 gaaattaatg ctctgaatcg cccgaagagg gaacgggcag tatgattcaa aaggctcaga 1121041 gtctgtctgg ggcaaataga tagtatgtta ataattcgct gacctgctca cggattcgcg 1121101 gattaaaata gcgatggttt tcttcataac cgtcgatgac aaatgtatag agtgtaaagg 1121161 cctcatcgcg ttccgtctcg cggattgcaa tttttctttt cctcagttct tttctgacct 1121221 ccatcaaatc cttttgtgct atttttaatg attcgctgat aagctgttta taaggatgct 1121281 tcaattttaa tgtgctttct tcaattccgg cgagatcacg gttaaaaatc gtaatggcca 1121341 tgggcaaaaa gagagcccgt tcaattaaat cgtatatttc ctcctgcaga tttggcatat 1121401 tgactccttc tttctaaggg aacgtttgtt ctatttgtat tctatatcgg ctggtgaaat 1121461 gtttcaagac agaaaaaatc accaaaactt tttagttttc tgctgataat gtgtagaata 1121521 aggatagaca aacccggtaa ggagtataaa tgttggagca ttttttatcc tatttgacac 1121581 aagaacattt aactgaatta tttcaaagct atagggcttt cggtccgctc attgctgtgc 1121641 tgctgccttt aattgaagca tttctcccgt ttttgccgct gatcgtgttt gtggtggcga 1121701 atacgaactc gtttggcttg tgggaaggat tcatcctatc ctgggcggga tcaactgctg 1121761 gttccattct cgtctttttg attgtccgtc aatacggaca gagaaaattg cttggattta 1121821 tccgcagtca tccgtctgtc agaaagctga tgttatgggt ggaaagacac ggcttcggtc 1121881 ccatgtttct tctgctttgt tttccattta caccgtcagc cgcggtgaat gttgttgccg 1121941 gtttgtcaag gatcggaacg cggccgttta ttttggcggc agcctcgggg aagcttgtca 1122001 tgatttttat gatcagcttc atcggatatg atctgcacgc gctgattaca cagccgattc 1122061 gaacggtcat cgccgtattg gtgatcactg tcttatggta tgtcggcaaa aaggtggagc 1122121 ggtatctgca tgtaagagcc agtcagcgtg agcatgatgg agggagacag taacatgaaa 1122181 aaacggtttt ggtttcttgc cggtgtagtg tccgttgttc tcgccattca ggttaaaaat 1122241 gctgtcttta ttgattacaa ggtagaaggc gtcagtatga acccgacctt ccaggaagga 1122301 aacgaattgt tggtcaataa attttcgcat cgatttaaaa ccatccatcg ttttgacatc 1122361 gtccttttta aaggccctga tcataaagtg ctgattaaac gggtaatcgg cttgcccggt 1122421 gaaacgatca aatataaaga tgatcagctg tatgtgaacg gaaagcaggt tgctgagcca 1122481 tttttgaagc atttgaaatc tgtttctgcc ggcagccatg taacgggtga tttttctttg 1122541 aaagatgtga cgggaacaag caaggtgccg aaaggaaaat attttgtcgt tggagataat 1122601 cgcatataca gcttcgacag ccggcatttt ggtccgataa gagaaaaaaa tattgtcggt 1122661 gtgatttctg atgccgaata aaaagacgct aattgaagag gcgtcttttt gtatgccgtt 1122721 tggaaaaatg tgttgaagaa aaatttgtaa ggagctataa tcaaaattgt tacctgtgta 1122781 acaaaattta tatatttttt tgactggagg gccgttttta ttggtttttg ttcgtttttc 1122841 atgaaacaaa aggagtggtg aatgatgatg aaatatgaag cagtgattat aggaggaggg 1122901 ccggttggat ttatgctggc ttctgagctt gcaatagccg gagtgggaac atgtgtgatt 1122961 gaacggcttg aaaaacctgt tccgcattcc aaggcgttga cgctgcaccc ccgaacgctg 1123021 gagcttcttg agatgagagg gattttagag cggttcgtat ccaagggaag caagatacct 1123081 accggacatt tttcaatgct ggatacccgt ctggattttt caggcttgga tacgagctgt 1123141 ccttacacgc ttttgctccc gcagtccaaa acagaaaagc ttcttgaaga tcatgcacga 1123201 agcctgggaa cagaggtgtt tcggggtgcc gaggcgctgg cggttacgca aaacggggaa 1123261 gcggtccaaa caatttttaa ggatcgggac ggcagtgtac ggacgatcac aagcaagttt 1123321 gccgttgggg cagatggcgc cgggagtacc gtccggaaac aggcgaaaat tgagtttccg 1123381 ggaacagaca gcactgtcac cgctgcgctt ggggatgtgg tgctcctttc tccgccgccg 1123441 tcaggtgtgc tgtccctttg cacaaaagag ggcggtgtta tgattgttcc gttatctcca 1123501 gaccgatacc gtgtcgttgt gatcagccct tatcgcacac aaacgccgaa agatgtgcct 1123561 gtgactgagg aagagctgaa agctgacctc ctgcgaattt gcggaactga cttcggttta 1123621 accgaccctt cgtggatgtc gcggtttggg aacgccgcgc gccaagcgaa acggtatcgg 1123681 gacggcagaa tctttcttgc gggtgatgcc gcgcatattc attttccggc gggcgggcaa 1123741 ggactgaatg tcggccttca ggatgcaatg aacctcgggt ggaaactggc ggcggccatc 1123801 aaaggctctg cgccttcttg gcttttggac agctaccatg atgagcggca tccggcagcg 1123861 gaagggctcc tcagaaacac ggaggcacag acaaagctga tcgatttcac tcaagcaggc 1123921 ctccatttgc gaagcatgat gtcggagctg ctggccttcc ctgatgtgaa tcgatatgta 1123981 gcggggcaaa tttctgcgct cgatgtcaga tatgaagctg atcgtaccat gccgccgaat 1124041 cgtttgaacg gggcaaggct ccctgacatg aagctgattc tttccgacgg caattcggaa 1124101 cggctgtaca gctttctcca aaacgggaca ttcgttttgc tgtcattgag gcaggaagct 1124161 gatgatcata tcgaagtaaa aggcttacgt acggtaaccg cctcgcttgc agaaccgaat 1124221 gaaaagttgc ggaatgtgca taccatattg attcgtcccg atggacatgt agcctgggcg 1124281 gtggatgcat cagcgcccga ttgttccgag gtgattcaaa aagggatcag ccgctggttt 1124341 tccgtcacca gccgagtata attcaattcg attgtttcat ctgtaacaaa acggtatgat 1124401 agaagaaaca atcgaatgaa aaaggatgga aaacccgatg aacacagatc atacgaaacg 1124461 caatcttttt gaattgtatg cggagctcat tcatcagcag gagaaatggg aggggcttat 1124521 taaagccttt ttatctgacg aattgaggaa gctggatgta gagcacggga gtaaatctca 1124581 attgacgatg acagaaattc atgttctatc ctgtgtcggg gacaatgaac caattaatgt 1124641 cacgtcgata gcagaaaaaa tgaatacgac aaaagcgact gtatcacgca tcagcacaaa 1124701 attgctcggc gcaggcttcc ttcacagaac acagctcagc gataataaaa aggaggtcta 1124761 cttccgattg acgcctgctg gaaaaaagct gcacagtttg cacaaatatt atcatcagaa 1124821 ggctgaacag cgttttctgt cattttttga ccgctatacc gaggaagaga ttctttttgc 1124881 ggaacggctg tttcgggatc tggtgacaaa atggtatccg tcgtcagaag aaattgaagg 1124941 ggggcttcct agcattttta aataaaaaac acgcactgcg gtgcgtgttt ttcgctttgt 1125001 ttctatcttt ttcaaggctg taacgtaaat cagatttcct cttgaagaat gaaattcaag 1125061 atgttcagga atttgcactg cttatacgat atgtctatta gtatctttat tttatacgtt 1125121 ttctactgtg tttttgatgc tttgttttca agtgaaatag ggtcttctgt tttagttctc 1125181 ctaatcttta cagaaatacc tactagaatg accgccatag ttgtaaatat tcccatggtt 1125241 aataagatcg tatcctggtt taaactccat ccaattaaga aagagatgat cgctcctccg 1125301 aaacttgccg aggcaataaa taaacttgta acttcgtcaa cgtacttctg aataatgatt 1125361 gatgctagtg ttaaagcaat gggaaatatc cccgctatac ttaggccaat caaaaatgta 1125421 ccactcaatt gaagtattgg gttacttata taagagaagg caatcaacaa aacaattaaa 1125481 caactacagc taaaaagaag gtatttggaa aaatcaagcc ttctacttac gaaaccaatc 1125541 aatattcttc ctatgatgat ccctacccag aaaaaggaga cacttataag actaatttgt 1125601 tcattgtctt ggtttatcat gattgaaggt aaaaagttgg caaaatttgt ttcaattcca 1125661 gcatatagga aagcgaaaaa tacaaaaaag cctaattgct ttgatttttt tctatctcct 1125721 ataaagtatt gaaatgctcc tccatctgga aaggtcactt gttggttagc attcttagcg 1125781 tactctcggt tcttagacaa gaaaattaac caccctacga ataggacgaa taaaaaggtg 1125841 aatatacagt aatatggtaa aaaccagtta ttgatatcta tgaaggaatt aattaataat 1125901 gggaaagata aagcgcctaa tccaaagaga acttccagct tactcatttt ttctgcatta 1125961 ctttcgaaat tagcaataac aaatgaacca actgtcgttt ctaatgtgcc tgctccatat 1126021 cctaagagaa aagccattac aataatataa taccaatcct tggttagaaa aaagatactt 1126081 aacgctacaa gcattattgt caaagctaaa gtaagtgtcc taaaatgact gtatttctta 1126141 atcattaaag gtgcgattaa tactccgctt agaaatccgg taaactggaa gaagattatg 1126201 accgaaatat catctgttgt cttgttaaaa gcctctaata aaaatggtgt caaactccct 1126261 gttgatatat ggataatacc tactgtaaaa aagaaagcat atccaaataa atatgtccct 1126321 cttaacattc attacacccc tatatgaaaa agcaggaaag taaattcctg cttttttagt 1126381 aacttctctc tttgaaatac tagttgactg ctgaaacaga catgggttga gagttgctgt 1126441 ctttctcaaa gaacatttct aatacttcct gagatctaaa accatcacta aaagaaggga 1126501 tctcaaccca atcattctga gttgatgcaa tccaattgat taactcgctt ctaaaagaat 1126561 cagcccatcc ataaaactcg tttggcggat cgtttaatag gctttgcggt actgggcagt 1126621 ctaccacgtt caagccatct atgagcttgt aaacgtgagg attacctgtg tggtatttaa 1126681 actctttttt gtgtccaact acctcaatgc taaaaccaca gtcttcaggt acagaacact 1126741 ttgatgtgat gatatttaca aataccttgt tcttcagctg gccataaatt tctgcatagt 1126801 catctacaag tacctgttta tcctcttttg tttttacatt tgtgttcatc tttgccctta 1126861 ctgattctgt gatgaaatca ctctcgaaca aataccatac catgtcaata aggtgaatac 1126921 ccagatcccc caatgatcca ctcgtcttct tactattagc gtcatctctc caagtaaact 1126981 tcttacgtct aagtgcacta tttttcttga agtgtacttt tatggacagt atgttaccta 1127041 gttcattatt gataattaag ctttttaaga tatttacgta agataaatat ctataattaa 1127101 atcccatact ggctcttacg ctcaaccttt cagcagtatc tttcattatg cttgcttctt 1127161 caagagaaat agccataggc ttttcacata atacatgctt atgttttcct aatgcttgca 1127221 aagcatgttc tttatggcaa aagtttggtg atgctacaat taaaccttct gaggcatcaa 1127281 ttagttcatc tacgttttca aatgacttcc cgccgaaagt tttcacaaag ctttccgcat 1127341 tttgttgatt tatgtcatat acccctacta actctgcatt ttttattgta gataaagcag 1127401 ttgcatgcgc tcttgcaata ccacctgcac ctatgatgcc tatcttcttc atttttattt 1127461 cctcctcatg atccaattaa tttttttaag gtattagtaa ttccttttga gtactcacta 1127521 tcagttataa ggttgtgcaa gtttttggct tcctgtgttg cattttttag cagatatcca 1127581 ttccctactg tctgtaacat acgaacatca tttccactat ccccaaatgc gatagctctt 1127641 tcggtattta ggttgtattt ctctaacata aacgttacaa tttcattctt tcctgtccct 1127701 atggggataa aatctacatc atagctgtct tctggatcgc ctgctaaggg attacaccga 1127761 tttatattta ctgaaacgcc gtattcttcg cagatttttt caatagctaa taggtttttc 1127821 ttgtcgttta tttcatcttg ttcctgatag tagaagttat gcttataccg tgactttcct 1127881 aattgggttt gaggattcaa aagaatgtta tgattttcat gcagctgttt cacaagtttt 1127941 tcaacctttt ctttactaaa cccttcattt atgcgactgt tccacttgtt atcttgctga 1128001 ccgaagttat gctctgaaaa gtacgtaatt tcagttccaa gatcactagc tataaaatgc 1128061 ggaaaatatc taaattttcc tcgtcccatt ttatcgagaa tagattctat actgctccca 1128121 gtaacccatc cgattattag ctccccatct ttactttttt gttctagata gtcttcgagt 1128181 tcatagatgt cttgttgctt ttgttcgtcg attgtatgcg gaaaatacgt ttcatcaaaa 1128241 tcacaaaaaa caatatattg aggatgttca accgtggata acgttttata ctccgatttc 1128301 ttgcttaata acatgaaaca gtccctccat tactctgtct tgttcttcta aagtaaatga 1128361 cggatataaa ggcaaatgca gtacctgact atgagccttt tccgtatgaa ccaattggag 1128421 tcctgcatac ttgtcctgta ctaaaggagt tttttgcata tgagaaagta ttggataata 1128481 tacatctgtt tgaacaccaa aatcttcatt taatttagtc atgatatctg ccctatcttc 1128541 tgttcttacc ttaataggaa acagatgcca tacatgatct tcacttaatt ctggtaattc 1128601 aatatagcct ttattctgca actctgctaa ttgggtaatg tatctatccg ccaagaacaa 1128661 tcttttgaag ttgtttaatg aaaggtactt cattctctct aaaccaattg ctgcctgtaa 1128721 attgtccatt tttgaattaa atccaaaatt gatgactttc ttatttttta catttacttc 1128781 aaaaccgtga taactaaatt gaatgcattt tttagcgagt tcttcattat cagttgctat 1128841 tgccccagcc ttgccacata caccaaaatt cttataggga ttaaaactta atgtagtgat 1128901 gtctgcatac tttcctaagt ctgtcagtcc aattccttgg caggcatctt caattacttt 1128961 taatttataa cgatttgcga tttgacggat atgctgcatg tctgaatgtt ttccgtataa 1129021 atgcacaggt agaataaact ttgtataagg agttattgct tcttcaattt tgtcaggatc 1129081 gatgcagaat gtttgtgggt taatatctac atagatagga acgcctcccg aagctaacac 1129141 agcattttca gtagctgaaa agctattagc cggcatgata acttcatccc ctgggtttaa 1129201 ccctaaagcc aataaaccta tcataatagc atcggttcca ctgctggttg caattacata 1129261 ccttttatgt aaatatgtag ataaaacttt ttcgaattgc tctaaatagg gaccactcgt 1129321 aaattttcca gttggcaaaa cttcagttaa tgtatttaag atatcttcca cttcatcatt 1129381 ggttattaat ctgtctacag gcaaaaaagg gactttactg atttcacgat ttttttgata 1129441 gttgaaaagg tcatgttcaa tatctatctt ttcttttaat acttgtttcc accgctcgtt 1129501 tacaatactg tcttcaataa caagttcttt tccttgtacg tcacctttta agtgttttaa 1129561 tagtgacatg ttttctttgc ttttacctga aatcttaacc tgtttttgca tgaacagtac 1129621 ctccaatgat tttataatct aaaaatttat tacaaattta tcctagtttc tgaaatcggt 1129681 aacatgtcaa caactttttt aaggaaggga aaatatgcct acaattgatg aaatagcaaa 1129741 attatgcaat gtgtctaaaa ccacagtgtc aagagtattg aataatcatc cttatgtgtc 1129801 gaaagaaaaa agagatatga tcttaaaggc tattaacgaa cttgactaca ctcccaatta 1129861 tttagctcgg aattttagga gaaataagac acaaacgata gctttatcgg ttccgagtat 1129921 cgaccatcca ttttttgctc aattaataaa aggggtctct catgaagtac tgtttaagaa 1129981 ttacaaggta attgtatttc agacctttta tgacaaacag acggagctag aattactaga 1130041 gttattgaag cataaagaag tggatggcat tattcttggg actttagaaa atgaatggga 1130101 tcagatatcc cctttcttaa agtatggtcc tatcttatta tgtaatgaat atcatcactc 1130161 agcggacatc acgataattg ggtatgatga atttgaagcc gcatacatgg gggtagtaca 1130221 tttaattgaa agagggcata aaaaaattgg gttttgtttt gatactccat atagcgaagc 1130281 tcaatgtcag aggaaagagg gttatttgaa agctttacaa gattacaatt tacatcatag 1130341 aagcgaatgg atattcggcg aaatgtttaa tatcgaggat ggctttcgtg tttttcataa 1130401 gataaaggat ctaaaggaca gaccctcagc aatatttaca ggaaatgatc aagtcgccgc 1130461 agggattatt aaacaggcga tgaaaaatgg ctttaaagtt ccagaagact tagctgtaat 1130521 tggttttgac aaccaattga tttgccaagt cgttactccg accataacaa caattgatat 1130581 ccccgtaata gaattaggcc aacaggctgt gttgaaaatc atcgagtcca tttcgggtaa 1130641 tgcctcttta aacagaagaa ttattaaact gccaacaaag cttattataa gagaatcaac 1130701 gtaacgatag atttcccttt aacattttat atctttatat aagaaaaaga ggttattcat 1130761 tttaacctct ttttcaatcg taagtcgtca attatttctt tcatttcacc ctctggcagc 1130821 actcacttca aatctgatcc attaacaacg aaatatccgc ttatatttcc tcatctcgat 1130881 ggtttgcgaa ttaaaagttc ttgaaccctt ttttcaacta ggcactactg ccgctgattg 1130941 agctcttttt gtcttttttt tcaccatgaa gatggtgaag caggcgataa aacggcggca 1131001 gcagggcaat aaccagaatg acgcgaatga cctgaaccgc aacgacaaag gtggaatcag 1131061 catgtaaggt aactgacgtc gtcgccatct ctgcaatccc gccgggcgca aatgccagaa 1131121 cagaagtgat gagcgaaatt cctgtcagct cggaaacgat cacggcgctc aaaaacattg 1131181 ctgcgattaa accgacggac gagacaaacc cgacgatgat aatacgggtg acgccggcaa 1131241 acatgctttt gtacatctta gagccgatcg ttgccccgag aaatacttgt gatacatggt 1131301 tagcttgtga caaccaccat gccgtcatgt cgtgccctgt caccgcagct ccgccaacat 1131361 gtacaattgc tacaccgagc atgctgccga gcagccatgg agctggaaat tttaaaaatt 1131421 tcgcagcttt gcaagctccc caggcagcga gaataagaat gacggtccac aaaacgggag 1131481 cgagcctaaa atctgtcgtt gcagaagaaa tcgtctctgc tgcggcactt gcggtacgat 1131541 cttgttttgt atagatcaga atgactaaaa acggaatgga aagcaccacg agcagcacac 1131601 gcatcatttg aacgaggctg actatagcgg tattggcgcc tacttcctgt gcgatgctcg 1131661 gcatggcgga aagtccgccg ggagcggtgc cgacaaagct agtcatcata tccgttttgc 1131721 tgaaacgcca aagcacatat cctgacagca tggccagcag gatagacaat atcagcataa 1131781 cgccgactga aaaccaatgg tctttgagaa cagagagaac ggataaattc agcttttggc 1131841 ccaattcgat gccgaggatc atctgcccga gggcgagcca tcgtcggtta attccttttt 1131901 ggtctggtgc catcatcagc catgccggcc gtatcatggc gaggcagcag gcgacaatca 1131961 gtgttccgat catccatcca attgatattc cggttaatga aagaataaac cccccggctg 1132021 cactgattgc gataaaccat agatctttga ggagattttc gtctttcttc aatgtaaaac 1132081 ccttcttcct ttttcacgta acactccaat tgttcacgta gtgaatgtat ttattactat 1132141 agtatatttt tgttgataaa gaaattatga attattttct ataagcgatt cacttttctt 1132201 atgaccttgt gttcgagctt ttctattgtg taagtcagag ataaacccgc tgtcagcaga 1132261 cacacggcaa gagcgtaaaa aatcacttct ccgccaaatg atgtcaggat cagcccgcct 1132321 gccagcggtc cgattgagcg ggatatatcc caatgcagac catagacagc ataaaaccgg 1132381 cccagcaaat gaggcggcgc caatttcgat atgaaggtct ggatgtgggt tagcccgatg 1132441 ctttcaccaa ccgtcatcac cgctgccgtc actaaaagca ttgtcagaga ggttgagcat 1132501 gcaaagccgg ctgccgcaag ggagtagcaa atataagtaa tgaagaggat cgttttcatt 1132561 gaaagctttt cggtcccttt gacaagaggt acttggagaa cacagctgaa taaagctttt 1132621 gctgctgaat agatggtcag catggacaga taatcagaaa acatgttttt gctgaacagc 1132681 ctgtatgttg tttctgtttg tgcatataac atgctgatgg ggagagaaag cagcaaaaga 1132741 agcaggacag gcctgtatat tgtaaagctc gcggacattt tcggggtaac agctgggtgt 1132801 agcggctttg tctcaggcag tttcagtgca gcgatcagaa agtagataaa caatgctgca 1132861 gcatctaatg cgaatatcca cacggggtta tgattgtaca gcagcatccc cactagcggt 1132921 cctgccgtca gacccgtcga atagatcgca ttgatgaccg caaacacttc cgaacgtctg 1132981 ctttccggcg tgctttcagc gatttgggcg cgggaagcgg gaatgtacaa cgatcttccg 1133041 atgccattca tgacatagag aatagcgaaa acatacgcat gctcagcaaa tacaaaccct 1133101 gtcattgccg ctgattgaag aagcaatgcg gtcaaaatcg ctgtgcgccg cccaagccga 1133161 tccgtcaccc gtcctgcagc gagcgtcagg aaaatatcag caaatggctg aaggctgatg 1133221 atcagcattg gcatcatgat actgccgttt aattgttcat gcagatacag caccataaaa 1133281 ggtcccatca ttgcacctgt caggcttgtc agcaattcgc cgaaaaagcg gagccgaacg 1133341 ggagcggtat atctcgattt tatagagtga aaactggtca acatgtgatc gccgcctttc 1133401 gctgtttgat atagtagtag tgtatagaag gggcggcggc ccaaaaagtg aagaaaagaa 1133461 gagataaaag ttcccctttt gtcgggaggt gcggggattg aagctgatag agcactacgt 1133521 ggcgcttgta aaaacaggct gcgccgagta tgggcaaatg aacgaaatga cgctcactga 1133581 gattgccgac tgtttatttt gtacagaaag aaatgcaaag ctcattttac ataagctgga 1133641 gaacagcaat tggattatcc gggaaagcgg ggcggggcgc ggccgcaaat ctaaaatcgc 1133701 gtttcttcgg aggcctgagg aactgcttct tcaaactgca aaggaatata ccatgtcagg 1133761 aaagcttaaa aaggcaaagg agctgcttca gcagtatcag tccgcgtttc cagggcttca 1133821 aaacgaatat aacatgtggc tatcagaggt attcggattt gtgacggaga caggcgagaa 1133881 tggggcgaag gatgtcctgc ggctgttcat cacgcctgaa tctgtcagca gtttggatcc 1133941 atgccaaata tttttgcggt ctgagggcca tttcgtcaaa cagatatttg atacactctt 1134001 cacgtttgat tcggatatgc aggagccgaa gcctcatttg gttcatggat gggaagaggt 1134061 cggaaaaaaa caatggagat tttttcttcg aaaaggtgtg ttatttcata atggacagcc 1134121 gctgacatcg cgggacgttg cgtttacatt tcagcgcttt ttggaactgg ctgacaaccc 1134181 gtataaatgg cttctgcacg gagtgaaaca agtcttagaa aagggccctt attgtgtgga 1134241 gctcatactc gataagccga atgcgctttt gccgtatgct ctttgtgatg aacggctgtc 1134301 catactgccg gcagaacagg gcggcgggaa aaatggaaca gggccttttc agatgaatca 1134361 gcaacatagc gggatgcttg tgcttgaagc caatgagcgc tacttcaagg gacgccccta 1134421 tttggatcgc gttgagtttg tgttttctga gcaagccgga gagatgaacg gttttaccat 1134481 tcaagaaaaa caaacatgtc ctgagcagca aactgtcttt gatgagcggc atgttcagta 1134541 tttgtcgctt aatctgaaaa agaaggggcc tcttcagcac cgaagcttta gaaaagcgct 1134601 ccggctgctg atttcctctg aacggctcgt tcgtgaagcg ggagggcacc gaagaattcc 1134661 ggttacgtcc tttttgcatc cgagtccttt tgagtgggag ggcgtttcgc catctgaatt 1134721 gttgaaaaaa agcggatacg agggcgaaac aatcgtgctt tatacctttt cggaaacgga 1134781 tcatcgtgag gacgccgaat ggattcaaaa tatttgcgcc cagcacggta tcaggcttac 1134841 acttcaattc tgtgatgctg ctgatctgcg acggccggaa atcgtgcaga tggcggatat 1134901 cattcatgac agtgcgacgt tttatcaaga cagcgagttt ggttttctgc atttgctgct 1134961 gtcggagaac agtttcttgt atcagcatct atctgaaaag ctgacacaga tttgctcagg 1135021 aatgacagag cggatgtttt ccatgcctga ccgctgttcg agaatcaaca tcctgcgtga 1135081 cattgaccgg cagatgatac aggagctgaa cgcgatcccg ctgtatcaaa atgtgctcca 1135141 ggtgacatca agtaaaaatg taaaaggcct ggtgcttgat gaagagggat ggattgattt 1135201 gtactccgta tggctgtcca aataaaaaga gggttctttt ttgaaccctc ttttttacgc 1135261 tgccatgctg cggcattgtt cagcacaggt gaagcaggct ttcgcacatg cttggcaatg 1135321 atcatgatcg tgctttccgc attcagtgcc gcatgcttca caaatatcgg cgcaaagtgc 1135381 acaaatttct ttcataaacg ggctgtccgt ttgcatggct ttgaccgcca gcgcgcaaat 1135441 atccgcgcat tccctgtcaa gccggatgca tccgctgaga tgatgctgca cgctttcttc 1135501 caagcattta gtgaaacaat gattgcaagc cttcatgcaa tcgatgcaag cctcaataca 1135561 agcctcagaa tattgctcca tggttgattc cccctgtatg acagtatatg gttttatgtt 1135621 tcacggctgc atttgaaaaa aacaggggag tgtgttttta gctaagggga tatgtacata 1135681 taccctgaat gggtatatct aacgttccat cagatagtat aggaaccaga cagcgtgatt 1135741 ttgttcatca cgtgctgcgc gcgtaaagac gcctttcgct tttaagtttg acgtttcctc 1135801 ggccgcacgc aagtaaaagt cgacggtttc ttgttcatct ttaaaagcgg cgtccagtcc 1135861 tcttgtgaaa ttgtccgggc attcttccgt ttgtttcggc atgatgtgtt tgccggtaat 1135921 tgaaccatac agtgtggaaa attcacggag gtggcgaatc tcgtcacgcc tgatttcttc 1135981 aatctgtttt ctgacctcat cgctgtgggc gagttcggca agcttgcggt agcattgaat 1136041 agcactgaat tctccgttga tggccttctg caaattccga atcaaaacag gatcttcccg 1136101 gtatggcacc ggatagggat agtagctgta atgcaagggg attcaactcc attcttagga 1136161 attgggcttc tgtaaaagta tatgttgggc agggagagat gtgcggagat aatcagcttt 1136221 ttatatgtga aaaggccgtt tttaccaata gatcagattg gtcattttcg tcaacattcg 1136281 ataaaatata gagagataaa aagagagggg tcttctaatt tgggagcaga gtttttagta 1136341 ggcaggtccg ggagtggaaa aacgaagctg atcatcaaca gcattcagga tgaattgcgc 1136401 cgggctccat tcgggaagcc gatcattttt ctagtcccgg atcaaatgac gtttttaatg 1136461 gaatacgagc ttgctaaaac gccagatatg ggcgggatga tacgcgctca agtgttcagt 1136521 ttttcacgat tggcctggcg cgtcctccag catacgggag gaatgagcag gccgtttctg 1136581 acgagcaccg gcgtacaaat gctcctgcgg aagctcattg aggagcataa acaggagttc 1136641 aaagtctatc aaaaagcgag tgacaaaagc gggtttaccg cacaggttga gcggatgctg 1136701 acagagttta agcgctattg tctggaaccg gaggatatcc gccggatggc ggaaagcgga 1136761 acggcttccg agtatcgcgg agaacgtgtt ttatctgaaa agctccatga cttatcaatt 1136821 ctgtatcagc aaatggaaaa aagcctcgca gatcaatatc ttcactctga ggattatttg 1136881 acattgctgg cagagcatat cccgcttgcg gaagatataa aaggcgccca tatctatgtg 1136941 gatggctttt atcagtttac cccgcaggaa ttcagggtgt tggagcagct tatggttcat 1137001 gcggagcata tcacgttttc gctcacagcg gacaagccgt catatgagcg ggagccgcat 1137061 gaactggaat tgttcagaat gacggggaaa acctattacc gcctgcatca gaaggcgaag 1137121 gaactgaatt tggacattac gtataaagag ctgagcggga ctgagcggca tacaaagacg 1137181 ccggaattgg cgcatctaga ggcacagtat gaagcgcgtc cggccattcc atacgcagaa 1137241 aaacaagaag cccttactgt gatgcaggcc gcaaacagac gagctgagct ggaaggcatt 1137301 gctcgggaaa ttcacgccct agtcagagag aagggatatc gctataagga tgtagcaatt 1137361 cttgcgcgcc agccggaaga ctacaaggat atggtgaagg aagttttcgc agattacgag 1137421 attccttatt tcattgacgg aaaagcatct atgctgaacc atccgttaat tgaatttatc 1137481 cggtcgagcc ttgatgttct gaaagggaat tggcgttatg aagcggtgtt tcgctgcgtg 1137541 aaaaccgaac tgctattccc gctcaatgaa ccgaaggcca aagtgagaga acaggtcgat 1137601 cagctcgaaa attactgtat cgcctatggt attaaaggcg accgctggac aaagggcgat 1137661 cggttccaat acaggcgttt tgtgtcattg gatgatgatt ttgcgcagac tgatcaggaa 1137721 atcgaaatgg aaaacatgtt gaatgacacc cgcgattgga ttgttccgcc gctttttcag 1137781 cttcaaaaac gcatgaaaaa agcgaagacg gttcaagaga aggcggaggc gctctatcgt 1137841 tatttagaag agacggatgt gccgctgaag ctggatcagg aaaggcagcg tgctgaggat 1137901 gacggcagaa tcattgaagc gcagcagcat cagcaggcgt gggacgcagt cattcagctg 1137961 cttgaggagt ttgttgaaat gatgggagat gatgagattt ctcttgattt gtttcagcaa 1138021 atgatagaag ccggcgcgga gtcgcttaca ttttctctaa ttccgcctgc gcttgaccag 1138081 gtgtttgtcg gcaatatgga tttgtccaga atgtatggca cctcctgcac ctttgtgctc 1138141 ggggcaaacg acggcgttct gccggcacgc cctgatgaaa acggggtcct gtcggatgat 1138201 gaccgggaat ggctgaaaac gattggggtt gagctatcct caggcggacg agagcgtttg 1138261 cttgatgagc acttcctcat ctacatggcg ttttcaagtc cgtctgaccg gctttacgta 1138321 tcgtatccga ttgctgatgc ggaaggaaaa acgcttttgc cgtcgatgat cgttaagcgg 1138381 ctggaagaac tgtttccgca tcataaggag cgcctgttaa caaatgaacc tgaacaggtc 1138441 agcgatgagg aacagctgat gtatgttgtg aataaaagcg tggcacagtc ctttaccgcg 1138501 agccagctca ggttatggac tcgggaatac gacatcagcg acgtctggtg gagcacgtac 1138561 aatgtgctga tgagtgagca ggacaggctg caatcgaaaa agctgttctc aagcctgttt 1138621 ttccggaatg aagtgaagca gcttgaacgc agcgtgtcga gacagctcta tggtgaacgt 1138681 attcagggca gtgtatcgag aatggaaacc tttaacgcat gcccgttttc ccattttgcg 1138741 tcacacgggc tgcatttgaa ggaacggcaa ttcttcaagc ttgaagcacc ggatatcggc 1138801 cagctgtttc attccagctt aaagctgatt tcggacaggc tgcgtgagca aaagctggat 1138861 tggcgcgatt taacgaagga gcagtgcgag ctgttttcct atgatgcggt agagcggctg 1138921 gcaccgaaac tgcaaaagga aattctgctc agctcaaacc ggcattatta tgtgaaggaa 1138981 aaactgcaaa aaattgtgac acgtgtgtcc ggcattttaa gcgagcatgc gaaagcgagc 1139041 ggattcgtac cgatcgggct tgaactgggc tttggaggaa aagggccgct tccgccgctg 1139101 acctttcaac tgaaaaacgg ctgtacgatg gaactcgtcg ggcgaattga ccgtgttgat 1139161 aaggctgaaa gctcaaaagg cctgctcctc aggattgtcg attataaatc aagcgacaaa 1139221 ggccttgact tagcggaagt atattacgga ttggcactgc aaatgctgac gtaccttgat 1139281 ttatcgatta cacattcagc tgactggctc gggatgaggg cgacgcctgc cggagtgctg 1139341 tatttccata ttcatgaccc gatgattcaa tctaatctcc cgcttgggct tgacgagatt 1139401 gaacaggaga tctttaagaa atttaaaatg aagggcttgc tcctcggtga tcaggaagtg 1139461 gttcgcctca tggatacaac ccttcaagag ggacgttcaa atatcataaa cgccggcttg 1139521 aaaaaagacg gctctctcag atcagactca gcagcagtcg gtgaaaagga atttgatctt 1139581 ttgacaaagc atgtgcgccg caccttccaa gaagcgggcg aacaaatcac cgacgggcgc 1139641 gtatccattg agccgtacaa aatgaagaac aagacgccgt gcacatactg tgcgttcaaa 1139701 tcagtatgcc aatttgatga atcactggaa gaaaacgagt atcgcccatt aaaggctgaa 1139761 aaggacaaga caatacttga gtggataaaa aaggaggcgg atggcaatga acattcctaa 1139821 accggcagac agcacatgga cagatgacca atggaatgcc attgtttcaa ccggccagga 1139881 tattcttgtg gcagcggctg cgggctctgg taaaaccgct gtgctcgttg aacgaatgat 1139941 tcggaaaatc accgcggagg aaaacccaat agatgtagac cgtcttctcg ttgtgacatt 1140001 tacaaacgcc tcagcggcag agatgaagca ccgaatcgca gaagccttgg aaaaagagct 1140061 tgtacagcgc cccggctcgc tgcatattag acgccagctg tctcttttaa accgggccag 1140121 catttcgacg ctccattcct tttgcctgca agtgctgaag aaatattact acttgatcga 1140181 tcttgatccg ggctttcgga tagctgatca gacggaaggc gagctgatcg gggatgaagt 1140241 gcttgacgag ctgtttgaag acgaatacgc aaagggcgaa aaggcgtttt ttgagcttgt 1140301 tgaccgctat acgacagacc ggcatgatct ggatctgcaa tttctcgtta aacaggtgta 1140361 cgagtattcc cgatcccatc ccaacccgga ggcgtggctg gaaagctttg ttcatttgta 1140421 tgatgtatca gaaaagagcg ccatcgagga gctgccgttt tatcaatatg tcaaagaaga 1140481 tattgcaatg gtgcttaacg gggcgaagga aaagctcttg cgcgcgcttg agctgacgaa 1140541 agcgccgggc ggcccggcgc cgcgtgctga caattttctt gatgatcttg ctcagattga 1140601 tgaactgatt cagcatcagg acgatttcag tgaactatat aagcgggtgc ccgccgtctc 1140661 ttttaagcgt gccaaagcag taaaagggga tgagttcgat ccagcgctcc ttgatgaggc 1140721 gacagatttg aggaacggcg caaaaaaact gcttgaaaag ctcaaaaccg actacttcac 1140781 gcgaagtcct gaacagcact tgaaaagcct agccgagatg aagcctgtca ttgaaacgct 1140841 cgtacagctt gtcatcagct atggaaaacg attcgaagct gcgaaacagg aaaaatcaat 1140901 catcgatttt tcggatttgg agcattactg tttagcgatt ttgacagctg agaatgacaa 1140961 aggtgaacgt gagccgagcg aggctgcaag gttttatcag gaacagtttc atgaggtgct 1141021 cgttgacgaa tatcaggata ccaacctcgt gcaggaatcg attctgcagc tcgtcacaag 1141081 cggtccggag gagactggta acctgtttat ggtaggagat gtcaaacagt cgatttatcg 1141141 attcaggctt gcggagccgc ttcttttcct ctctaaatac aaacggttta cagagagcgg 1141201 agaaggcacg gggcggaaaa tcgatttaaa taaaaatttc cgaagccggg ctgatatttt 1141261 agacagcaca aactttttat ttaaacagct gatgggcggc aaaatcggtg aggtcgatta 1141321 tgacgagcag gctgagctga agcttggtgc agcgtatccg gacaatgacg agacggaaac 1141381 agagctgctg ctgatcgaca acgcagaaga tacggatgca agcgaggaag cagaagagct 1141441 tgaaacggtg cagtttgagg caaaagccat cgctaaggaa attcgtaagc tgatttcatc 1141501 gccgtttaag gtgtatgacg gaaaaaagaa aacacatcgc aatattcaat accgagatat 1141561 cgtgattttg ctccgttcga tgccgtgggc tccgcaaatc atggaggagc tgagagcaca 1141621 gggcataccg gtttacgcca atttaacgtc aggctatttt gaagcggtcg aagtcgccgt 1141681 cgcgctttct gtgctgaagg tgattgataa tccgtatcag gatataccgc ttgcctctgt 1141741 gctgcgctca ccgattgtcg gagcagatga aaacgagctg tctttgatcc ggcttgaaaa 1141801 taaaaaagcg ccgtactatg aggcgatgaa agactacctg gctgctggtg accggagcga 1141861 tgagctttat caaaagttaa atacgtttta cggacatctg caaaaatggc gcgcgttttc 1141921 gaaaaaccac tcagtatctg agctgatttg ggaagtgtac cgcgacacca aatatatgga 1141981 ttatgtcggc ggcatgccgg gcggaaaaca gcgccaggcc aatttgcgtg ttctttatga 1142041 cagggcgcgt caatatgaat caacggcatt tcgcggcttg ttccgtttcc tgcggtttat 1142101 cgaacgcatg caggagcggg gcgatgatct tggtacggcg agagcgctca gcgagcagga 1142161 ggatgttgtc cgcttaatga cgatccacag cagcaaaggg ctcgaatttc cagtcgtgtt 1142221 tgtagcaggt ctcggccgga atttcaacat gatggatttg aacaaatcgt acctgctgga 1142281 taaggagctc ggatttggca cgaagtatat tcatccgcaa ttacgcatca gctatccgac 1142341 acttccgctc attgcgatga agaaaaaaat gcgcagggag ctgctgtcag aggaattgcg 1142401 tgtgctctat gttgcattaa cgagagcgaa ggaaaagctg tttctgattg gctcatgtaa 1142461 ggatcatcag aaacagcttg caaaatggca ggcatccgcg tcccaaactg attggcttct 1142521 gccggaattt gaccgctatc aggcgagaac gtatctagat ttcattgggc cggctcttgc 1142581 caggcacaga gacttggggg atttggctgg tgtgccagca cacgctgaca tctcaggtca 1142641 cccggctcgt tttgccgttc aaatgatcca ttcctatgat ttgcttgatg atgatctgga 1142701 agaaagaatg gaagaaaaaa gcgagcgcct agaagcgatc cgccgaggtg aaccagttcc 1142761 cggctcgttt gcgtttgatg aaaaagcccg cgagcagctg agctggacct acccgcatca 1142821 agaagtgacg caaattcgga caaagcaatc agtttctgag atcaagagaa aaagagagta 1142881 cgaggatgaa tacagcggca gggcccctgt aaaaccggct gatggaagca ttctgtacag 1142941 acgtcccgct tttatgatga aaaaaggcct gacagcggca gagaaaggga ctgccatgca 1143001 tacggttatg cagcatatcc cgctgtcaca tgtgccgtcg atagaagaag ctgagcagac 1143061 ggttcacagg ctttatgaaa aagagcttct cactgaagaa caaaaagacg ctattgatat 1143121 agaagaaatc gtgcaatttt tccatacaga aatcggcgga cagctgatcg gtgctaagtg 1143181 gaaggaccgg gaaataccat tcagcttagc gcttccggcc aaggagatct atcctgatgc 1143241 acacgaggca gatgagccgc ttttagtgca gggtattatt gactgtctct atgaaactga 1143301 ggacggatta tatctattgg attataagtc ggaccggatt gagggcaaat tccagcatgg 1143361 atttgaagga gcggccccga tcttgaagaa acgatatgaa acgcaaattc agctgtacac 1143421 gaaggcagtg gagcaaattg caaaaacaaa ggtaaaggga tgtgcgcttt atttctttga 1143481 cggagggcac attctgacat tatagcgaga tccataagct ccggaatttc aggcggagcg 1143541 ggtctcgttt tctatataaa agagaggtga aagcatttgc ggattttaca tacggctgac 1143601 tggcatcttg gaaaaacgct tgaaggaaga agcaggctga gtgaacaggc cgatgtgctg 1143661 gatgaactga atacgattgt aaaggatgag cagatcgatg ccattgtaat ggcgggggat 1143721 gcatttgaca ccgtaaaccc gccagcttta gccgagcagc tgttttatga aagcctgtct 1143781 gcgcttagcg acagaggaaa gcgcccgatc gtcgtcattg ccggaaatca cgataatcct 1143841 gaccgtttgt ccgccgcttc accgctgaca catgaaaacg gcattcattt aatcggttat 1143901 ccgacaacag agccgattca tattgaagtg ccttcagcag gagagctttt ggcggttgga 1143961 gcgctggcgt acccatctga agcgcggtta aatgaagtgc tatccgatac gtttgatgaa 1144021 aagctgctcc gtgatcacta tgatgtgaaa atcaggcagg cgtttgagca tatgacaagc 1144081 cggttccgga ccgatgcagt gaagattgcc gccagccata tttatgtggc aggcggaaac 1144141 caaaccgatt cagagcggcc gattgaagtc ggcggtgcat acacggtggc tgctgaaagc 1144201 ctgccggcag atgccgctta cgttgcgctc ggccatttgc atcgcccgca aacgatcaag 1144261 cgggcgcgga cgcttgcgcg ttattcagga tctccgctcg cctacagctt ttctgaagcg 1144321 ggctacgcta aatcagtgac gattgtggac gcaaagcctg gggaagaggc cacttggcaa 1144381 gaggtgttat tatcaagcgg caagccactt gtgaagtgga aagcggcaaa tggattaagt 1144441 gaggtgtaca gctggctgga tgaaggcaga gatcagaatg cttggattga cttggaaatc 1144501 cgtgtcgcgg accagctgtc acttgaagag attcacaggc tgcggaaggc gcacccgggc 1144561 tttatccata tcaggccggt ttttgaagaa cagaacaaag accgggaacg gatcgaggtt 1144621 aaacatgtct caatcgagga ccgctttaag aaattttatg aaaaacaaac tggcggtgcg 1144681 gtgccggatg aagaaatggt gaagctgttt ttagagcttg catcaggcgt tgaagaggag 1144741 gatgcgaaat gaagccgatc gccttaagca ttaaggggct ccacagcttt agagaggagc 1144801 agacgataga ttttgaaggc ctttccggtg ccggtgtttt cggcattttc ggcccgacag 1144861 gaagcggtaa atcctctata ctcgacgcaa tgacgcttgc tttatacgga aaggtggaac 1144921 gggcggcgaa taatacgcac ggaatcttaa atcacgccga agatacgctg tctgtgtcct 1144981 ttacctttgc gcttcagacg aatcaccaaa tctcatacaa agtcgagcgt gtgtttaaga 1145041 gaacggatga aatgaaggta aaaacggcac tttgccgctt catcgaaatc aaggacgagc 1145101 atacggtgct ggctgataaa gccagcgaag tgaataaaag agtggaggag ctcttagggc 1145161 tgacgatcga cgattttacg agagcggtgg tgctgcccca agggaaattt gctgaatttc 1145221 tgtctttaaa aggggcagag cgcaggcata tgcttcagcg tttatttaat ttggagcaat 1145281 atggagacag gcttgtgaaa aagctgagac ggcaggcgca ggaagccaat gcgagaaaaa 1145341 atgaaatgct tgctgaacag tccggtctcg gtgaggcgag ctcagaggca gtggagcagg 1145401 ctgaaaaggt tctcgaacaa gctgaagccc ggctggaagc gatgaggaag aaccgtgatc 1145461 aggcgaagga gcggtttaca gagcatcagg agatatggaa tgtccaaaag gaaaaatcca 1145521 cttatgaaga agaggaaaaa cgtctcgcag aagaacagcc gcatatagac agcatgcaaa 1145581 aacgcctgct ggaagcagaa acagcagcag cccttaagcc ctatgcggac cggtacgcag 1145641 aagcgatcca gcatgaggag caagctgaaa aggaacaaac gctagcccaa aaggatttag 1145701 cagaccggac agctttcttt cagcaaaaac atgaagagta tgaagcgtgg cgccagcata 1145761 aaagcgagaa agagcctgag cttttagcca aacaggaaca gctttcacgc ttgcaggaaa 1145821 tcgaaatcaa actgagtgag gccaagcaag aggaagagcg caaaaaggct gacctccggc 1145881 agaaagaaga ggctcttcaa tctgtcatga atgaattaga gaccgtaaca gaccgcctga 1145941 cacgagggca aaacagacag acagaattga agcagcagct caaatccctg caggtgacat 1146001 ccgatgagcg aaaaagctgc cagcaggccg cagagatggc attgcgcatc agacaaaccg 1146061 aggaacaaat caaaaaagag aaaaaacgaa gtgaagaatt gaacctcgtg ctgcagaaga 1146121 tgaatgaaga gaagaataca ctcgttcaaa agacggaagc ggaagaaaac aacatcattc 1146181 aggcatatga ggcagttcaa actgtgtacc atttggtgtg cgaaacggaa cgctcattaa 1146241 cacgtatgac ggaagaggct agaaagagtc aacacacgct tcacttacag cgtgaaaaag 1146301 caagggtggc actgctgaca aaagagttag cccaaaagct gactgccgga aagccttgcc 1146361 cggtatgcgg ttcaaccgat catgatccat ctgcctcggt acatgaaacg tatgaagccg 1146421 acagccatct tgaagaggac atcaaacgga cagatgtgtt attgacggaa gctgcagctc 1146481 tcagccagga gattctttca gccaaaatta tgcttgaaga acagtccgcg cgctttattg 1146541 aacagtgtcc gtttttgcag acaattcaag cacagaacct tgaagcggca gcttccttcg 1146601 aacatcagcc ggtgtatgaa gcatttgaaa ctgccaaatt tgaatggaaa cgaatcaagc 1146661 aggacattct ttctgttaag acacgaatgg cacaaatgat tggcgcctat caggagtctt 1146721 taaaaaaggc cgagcagctt aatgaaaaaa tcggttttga aaaaagagaa gccgaccgta 1146781 ttgaaagcat catcagtgag cttcaatcct caatggacag cagtctgaac atgtttaaag 1146841 aagcatttca gaatcaatct gtggacgaag cagaaaaatg gcagcaagcc attgaagaaa 1146901 aggaccgggc tgcagaagaa tgtgaaaaac gaattgagaa gagtatcgcg tttcttgctg 1146961 agcatgaagc acaaaaggaa aaactgcggg aatcgggaca ccggcttgag cgggaaaagc 1147021 tggagcttca ttatgcggct gaacgcatca agagcgtgat agctgattat gagcacgaac 1147081 tcggagatta tgcaaaagga gattcgattc aaatcaaact ccgctctgtc cagcaggatc 1147141 taaagctgtt aaaggaaaaa gaacaatctt tatatgaaga actgcaaagc gcccaaatga 1147201 agctcaacca agcgaaaagc cgcgcttctg caagcgagct cactcttcaa gaggcgaagg 1147261 gcagattgga aaaagcaaaa gctgcttggc ttgagcatac aaaaaacacc tccattaccc 1147321 ggactgagga ggttgaacaa agtctcatcc cagctgatga acttgaaaag atgaaaaccg 1147381 gcatagacca gtttatggat aaactgaagc aaaatgctgc aaacttaaaa cgagtagcag 1147441 agatacttgc cggcagagca ttatcagaga gcgaatggaa cgaaaccgtt gcagcattac 1147501 aagaagctga ggacgcattt ggcgctgcta tagaggaaaa aggcgcggcc gcaaaagcac 1147561 tggctgtcat tcgcgaccat cataaacggt ttaatgaaat tgaagctgaa ctgaaaaaat 1147621 ggcagatgca tatcgacagg ctggacaagc tgcaagctgt gtttaaaggc aataccttcg 1147681 tcgaattttt agctgaggag cagcttgaaa gcgttgcgag ggacgcctca gcaagactca 1147741 gtatgctgac aagacagcgc tatgccatcg aagtagattc tgagggcggc ttcgtgatgc 1147801 gggatgacgc gaatggaggc gtacgacgcc cggtttccag tttgtctgga ggagagacct 1147861 tcctcacctc gctttcactt gctcttgcgc tgtctgcgca gattcagctt cggggggaat 1147921 acccgctgca gttctttttc ttagatgaag gcttcggcac actggatcaa gatctgcttg 1147981 atacggttgt aacggccttg gaaaaacttc agtcagacaa cctggctgtc ggtgtcatca 1148041 gccatgtgca ggaactgcgt gcacggcttc cgaaaaagct gatcgtccat ccggctgaac 1148101 cgagcggccg cggtacgcgg gtatcacttg agttgatgta agggaggagc ggatatggca 1148161 aagcagattg ccggaatatg tgagctgtgc ggccggagcg atgtccagct gacagagcat 1148221 catcttacac cgaaagagga aggcggaacg tttttgccga cagcgatgct ctgtattcct 1148281 tgtcataaac agattcatgc cttatatacc aatcaagagc tcgctgtacg tttaaatgga 1148341 atggctgaac tcagaagcga tccagagctt gcccggtttg tcaaatggat cagaaaacag 1148401 ccgcctgaga agctgatcaa aactaagaaa tcaaatgaac gaaaaaagaa aaaatgacta 1148461 aaaagcagcc ctctctttgc agagcggctg cttttatccg tttccaacca tatcctgatc 1148521 gttgacatcg gggtctatat aatttgtcgc gttgactgca ttatttaata gaaggaaatc 1148581 tcccgtgttt cctgctcccg aaccgagcgc agattttgaa gagcttttcg gagaaaggta 1148641 aaaggaatca ccaaagttta cgactccgcc cgatatggaa ttgatagcta taggcccgac 1148701 aattgctggc ataaacgaca ccctttatcg aagtctctgt ttattatatg ttcttggcgg 1148761 gcgattgtga gcgcggagac tgaatctgtc tgatatgttt gagtctcgca tcaccgcgaa 1148821 taagcgaagc tgatccggca tgtaaaacag aagaggctga gaccccttga attttgatgc 1148881 tgcgaacata aatagccggc acctcgtggc aaaacgcgct ttgtacacct gtttcgggga 1148941 gcggcttcac ggcctgctgc tgaaagatct gatactcctt tttgttaaat gagccttcat 1149001 tatggtaaaa cgtggacaga gaacgctgca cagcaaatac ttttacactc atatcgattt 1149061 catttgtgtc gccaacttga aacacacttg cgatcccgag agaattaaac ttaactagtc 1149121 tgatgcgcga tatgcgttta agcattattc tggcgcaagc ggagcaaacg gcccaataat 1149181 aagagattca ggcggtgtat caaaaataga agacaggtag atggattcag tgtctccgat 1149241 gtggaaaacg gaggaactgg acacaccgtt catccgaata tccccgactt ccaagctgcg 1149301 gttgatgact gtaaagatca tgcttgctca tctcctttca tttctgatgg aatatgctcc 1149361 agaaagtgtt ctacagcgcg gatgacatca cgcttcacat gctcagcgat atgttctgca 1149421 tattgtgcag gcggtgtatt ttcttctttt ttgatatggg acatataata gtgaatcctg 1149481 ctgtccattt gttttctgat gtcttcaata acatgatgtc tgtttgtatc gtcaagtctg 1149541 ctgtcatatt gattttcaag ctgttccaaa atatctggga tttcctcggt taagtacatg 1149601 tcgacattct ggcggatctg ctgcatgagc tgagcgctct cttcctgctg catcatcccg 1149661 atttgcggtg tcgactggct gacgtcaaag ttttggacgc tgttcgggtc agtcggattt 1149721 aaaccgatat tcaaagtccc gtcgagcctt tcgattttca gctgatcaaa tttatactcc 1149781 acacgctcaa tggtagtggc cggccgctgt ttcatcgtat tcatttcagt ttgaatctct 1149841 ttcagctgac gttcgagctg ctgaatgtga atcgcctgct gctgaacgaa ggaattcaag 1149901 ttttgcaggt aagaggaaac agattgatca tacatgttct tcacctcttt catatgatta 1149961 acggccagga ggctggagcg ggaccaatga acctgtgtcg ggctcctgca gctggagcgg 1150021 ttgccctgag ccagaaactt ctggtgccgg ctctacatag cttcctgtat tatacaaatt 1150081 tgacagtgac ttgattgatc cggcgctccc gatttgcaga atggaggagt tgctgattga 1150141 ttccagccgg agatagttga tttgaatggt ttgattaata tagaagttca tgagcctcac 1150201 tccttttacg cattggccac gatcggctga tcaaccgcat cattgtcata cacattcgtc 1150261 gcgttttgat aattcatcac cttgaggctg tcgccggtat taaagctgcc agcaccggca 1150321 aacgttctga cctgagcctg aggagaaatc gtaatgcagt ccccgatgtg aacgactccg 1150381 ctcgtaccaa tcgcattaat tttaaacgct ccgacaatgg ccggcatacg agcacatcct 1150441 ttgttgaaaa attaaaaaaa gacaggtaaa gtgaaatgac aattccgatt tcaattgggc 1150501 tattcacgat agcttatgac aaacgcacat atgtgtgaga gaaattttaa ggggacatat 1150561 cggctctttg tgaaagcgtt ttattttttc gggccgttat gtttaaacat ggcaaaagag 1150621 gatgttgggt ataaattgag cggaaatgcg gcgaaggatg ccgctatccg cctatggtga 1150681 tttttgttta tttctttggt gtttttgcgt gtagaatgct ttttggagta tgtcgtgctg 1150741 cggtattcga tttttgggcg ggcacattct cgccctgagg tatatctcag aagtgctgag 1150801 caaaaatcgg agttaaatgt ggtgtattct aattgttata gaaaatgatt tacatacggg 1150861 agttttcaag atatctccca aaaatcattt cttctttaat ccgggtattc agcaggatat 1150921 ccagctcttg gctgcattga atcgtttctt ttgaattcat gccgtatttt tgtgcggttt 1150981 caattagtgt gatcctcatt tcttcaattt tactgttcat tacgctatct ccaattctag 1151041 attttatttt gatataaata caggatatcg ttagtataac ctattttggc tcaaaaggtt 1151101 gcctttcgtc aatttgacta aaaaagcgac aatttttgct gcggcctttt ttaatggaga 1151161 aaggactaaa gtcttgctaa gtgtgcttgc aaaaagtcct gccgttcctc aatttctcta 1151221 agtatgttgg tctgctcctt ttcgatttga aaggggcttt ttttgataaa aggatcatca 1151281 gcagcacttt gacaaatgtc aaggtgccat tcgttgatga gaggagataa tcgttcaata 1151341 gtaaacgacc gcttcagcac gtttttcatt aaggtgtgat attgcgacct gaaggcggga 1151401 atggatagaa gccttgacga aagcgtcttt ccttttgtca gaagcgggtc ttcttcatac 1151461 cattcttgta cggcaagcga tcttgtctcc atcggggaaa cgtaaagccg accggattcg 1151521 tttaaacaaa atgtgtagta aaagccttga ttggtgcagg tgttgccgat cagccacaaa 1151581 aaaaacagct tgacatccag atacaattta atcctttcag ccaattcgtc atctccggct 1151641 gtgcggatca gtatgaaaaa ttcatgtaag aatgccgagg aatcattgtt aaaaagggac 1151701 aatggaaccc ttggatcggc cgtcttcact ccgtaactcc ttttaccggc tggctgatgg 1151761 ttcttgatgt tcaaataaat gccttcaggc tggccattga tggtcagaaa gctgtacgag 1151821 gcaacgggag caggtacgcc gatctggtca aaaaaacaat aggcgagtct gcgccgcatc 1151881 agggacggat catcctgttc tgcattcaaa aaaagtgtcc tttcaccaag cagagacttt 1151941 tcccagctga tttcatagga tgccttttcc gctctgtcac gctgtgtgag aagaatggga 1152001 gaaacagatc gatctgttac gaaaagcccc ttggctgtac ctttcctttt cagctgctcc 1152061 cgatgaaaaa ataaatgcac gcgctccata ttctttcctc cttctcaaaa cgacatttgt 1152121 atgatatgta gagcaagccc gtcctgaaac gaaatgaaaa cggaattgag aaaaagggat 1152181 ttcagcattc gacagagaat acatgaagga gcattctgat ttaaaagatg atggaggaat 1152241 aacatgaaat ttgcgacagg ggaactttac aaccgaatgt ttgtcggcct gatcattgac 1152301 gatgagaaaa ttatggattt gcagaaggct gaaaaaaaac tgtttgaact tgagacgatt 1152361 ccgggatcgc tgattgaatg tatcgcagaa ggggataaat tcgttgcgca tgcaaggcag 1152421 ctggccgagt gggcaaagaa accgaatgat gagctgggat catttatgta ttcattatct 1152481 gaggtgaagc tccatgcacc cattccgaag ccatcaaaaa atatcatctg catcggcaaa 1152541 aactaccggg atcacgcgat tgaaatgggg agcgaggctg atattccgga gcatccgatg 1152601 gtatttacaa aatcgccggt aacggttacg gggcatggtg atatcgtaaa gagccatgaa 1152661 gaggttacct ctcagcttga ttatgaggga gaacttgctg tcgtgatcgg aaaaagcggg 1152721 actcgcattt caaaagaaga tgcatatgac catgttttcg gatatacgat tgtgaatgat 1152781 atcacggcgc gtgatctgca aaaaaggcat aagcagtttt ttatcggaaa aagcttggat 1152841 acgacatgtc cgatggggcc cgtgcttgta cataaatcat ctattcagga gccagagcgc 1152901 ctcaaggttg aaacaagagt caacggcgag ctgcgccaat ccggttcggc aagcgatatg 1152961 atcttttcca ttccggaatt aattgaaacc ctctcaaagg ggatgacgct tgaagcgggc 1153021 gacattattg ccaccggtac gccgtctggt gtcggcaagg ggtttacgcc tccaaaattc 1153081 ttgcggtcag gtgacaaaat tgatattaca attgatccga tcggaacgct gtcaaaccaa 1153141 attggctgaa taaaactgga gggcggaccc ggacccgccc gttttttctg ataatcatct 1153201 ttgtgacaga ggacaagttc atggtactat aagtggggta atttatctga tagggggaac 1153261 atatatgaca cacctacata ttacgacatg ggtggtagcg ctgattctgc ttttcgtcag 1153321 ctactcgctg tattcgtcag gaagtgcaaa gggcgcaaaa atcactcata tgattctgcg 1153381 gttattctat atccttatta ttttgacagg agctgagctg tttgtccgtt tcgccaactg 1153441 gaacggagaa tacgccggca aaatgattct gggcattatc accatcggcc tgatggaaat 1153501 gctcctcatc cgcaagaaaa aagaaaaatc aacaggaggc ctgtgggtcg gcttcgtcat 1153561 tgtccttttg ctgacagtgc tgctcggtct gcatttgcca attggttttc aattgtttta 1153621 atagaaaaac ctatgaaccc ggctctttga tagagctggt tttttttata tttatcccct 1153681 catattccaa atcatttaaa ataaccttaa aattccctgt aagcggtatc tcgtcctatg 1153741 aaattatgat accttcaagg agattcatta ttttgcagga gggataacat gaaacgcaga 1153801 aaattcagct cggttgtggc ggcagtgctt atttttgcac tgattttcag ccttttttct 1153861 ccgggaacca aagctgcagc ggccggcgcg atcgatcagg cggctgctct ggaaaacggc 1153921 aaagagcaga caggcgccat gaaggagccg gaacaggtga aatggtacaa agtgaccccg 1153981 ggagcaacgg atattcagaa aaactcacat atggcactga ccgtaaagag tgattcagta 1154041 ctgaatgtat ctgtatatcc aagtaaggaa aaagcgctta aagatgagac gtttgagatg 1154101 taccgttctt tcacagcgga ggatggaaaa agcgaagtca tttttccata cgcgtggagc 1154161 ggcccttact atgtaaaagt tgaatacctc ggagaagaag aaccagagga cggcggaacg 1154221 gcagaagcag ctgcagaagc caagtatacg attgggtata aaggcaccaa aaaacagccg 1154281 tcagatttag aagaggaaga agcttgtccg gttgaaatga gtgtcgatca gaagaaatca 1154341 ggaaaaggca tcctggataa gttgagatcg attcgtgatg agcagctgag ccaaacagca 1154401 gaaggcaaag aactgacaag cctttattac aaagcagcac cgtttatcgt tgcaaagctc 1154461 gcactcaata aaacagcaag aaatgaaatc tatcaggatc ttgtgacatt aaagccgtta 1154521 tttgacgatg tgtcagaaaa cggagcatca tcttcgtata aggtcactga aaaggatcaa 1154581 aaagcgatca accggctata tgataaagct ttacaatcag tcccgtcatt ccttaaagag 1154641 gagataaaga aacaagcgga ccgactaaat atgaagcagc tgcaaggcaa aacagcagga 1154701 gccattttaa cagaaaacaa tattgcagca aaaagtgaag ttcagacaac aaaggttatt 1154761 ttcaaggtga aggacaataa aagcctctca tccgtacata atgaaatgaa gggcttttct 1154821 gcaagcgcgc aatcgaaaaa agacatatct aatgtgaaaa aggcaaagaa actgtttgac 1154881 aatctgtatt catttgaact tccgaaagac gagaaacaga acggcgcata tacggcaagc 1154941 gccaaaaggg tcaaaagcgc tgctgcgaca ctatccaaga tgtccaatgt agagtttgcg 1155001 gaacccgtac aggaatacaa aagcttggca aacgatattc agtaccctta tcaatggccg 1155061 cttaaaaaca acggtgaaaa cggcggtgtc aaaaatgcgg atgtgaaata tgagcctgcc 1155121 aacacattgc tgtccaaacg caagcttaac gatacactca ttgcagtagt agacacaggc 1155181 gtagacagca cgcttgccga tttaaaagga aaagtaagaa cagatctcgg acacaatttt 1155241 gtcggacgaa ataacaatgc aatggatgat caggggcatg ggacgcatgt cgcaggcatt 1155301 attgcagccc aaagcgataa cggctattca atgactggat tgaatgccaa agcaaaaatc 1155361 atccctgtaa aagtgcttga ttccgcaggt tccggagata ctgaacaaat tgctctcggc 1155421 atcaaatatg ctgctgacaa aggagcaaag gtgattaatt taagtttagg cggaggctac 1155481 agccgcgtgc ttgaatttgc tttgaagtac gcagctgaca aaaatgtctt gattgccgca 1155541 gccagcggga atgatggaga aaatgcctta tcttatcctg catcttctaa atatgtgatg 1155601 tcagtcggcg caacgaatcg catggatatg accgctgatt tctctaacta tggaaaaggt 1155661 ctggacatct ctgctccagg gtctgatatc ccgagcttag tgccgaacgg aaatgtcacg 1155721 tacatgagcg gaacgtctat ggcgacgcca tatgctgccg ccgctgcggg actgctgttt 1155781 gctcaaaatc ctaagctaaa aagaacagaa gttgaggata tgttgaaaaa gacggcagat 1155841 gatatttcct ttgaaagtgt cgatggcgga gaagaagagt tgtatgacga ttatggcgat 1155901 ccgattgaaa ttccgaagac acctggtgta gactggcatt caggctacgg gcggctgaat 1155961 gtcatgaagg ctgtcagcgc agctgattta cagcttaagg tcaacaagct ggaaagcact 1156021 caaacagctg tcagaggaag cgcgaaggaa ggcaccctta tcgaggtgat gaacggcaaa 1156081 aagaaactcg gcagcgccaa agccggaaaa gacaatgcgt tcaaggtgaa tatcgcgact 1156141 caaaaacagg atcaagtact gtatctgaaa gcaacaaaag gcgatgcgaa aacatcgtat 1156201 aaagttgttg tcgtcaaagg aaaaccttcc ggcacaccga aagtaaacgc ggtgaaaacg 1156261 aaggatacgg cagtaaaagg gaaggcaaac agcaaagcga tgatcagagt gaaaaacaaa 1156321 tcaaagaaag tcattgcttc tgccaaagct gacgcaaaag gaacgttttc ggtgaaaatc 1156381 aaaaaacaaa aagccggaac ggtgctgtac gtcacggctg tggatacaga taaaaaagaa 1156441 agcaaggaag caaaagttgt tgttgaaaag taaccaaaaa gcggtgctcg atgcaccgct 1156501 tttttatttg cgcccccgtt ggactgctgt gtacataatg gatcgctttc cgtttgaagc 1156561 cgtccattca aaacggtctc ctgtcccttc gctgctgtag ttgtagtgat gctgcatcgc 1156621 gcattgtgcg gtgtcatttg aaaagtgata aaaggacaca ccctgccccg ccgaagtatt 1156681 cgaaaagact cctttattat aagaaaagac gcaatcgaat accgataagc cgaagctgtg 1156741 caagtgctgc agaaatgcga gaaaggtttc gtcgtcaagc gaatccaaaa gcgccatgag 1156801 cggccgcttg actgatttct catagcggat gcgttctccg ccggaaaggg agatgttttc 1156861 tgcaccgcat gccaaaacca acttgtcctg aaagccggct tgctcccact ttcctttatg 1156921 atggatccag attgggctgt gttggagact gtccgccagc agtatatcgc cttcaccgtt 1156981 ttcgattaag cagatgccgt cttcaatgag gatggtgccg tattcccact ttcgttcctc 1157041 tgtatataac aattgtttcc gtttcatcca tgctgtctcc tttttcttca ttcctctctt 1157101 ttctttccaa ttcaagcctg tcccatacaa ctcttttatg gacaaatcaa ctatctgcct 1157161 atagatgcat aaacttacta aggtgctgaa agaaacgaaa ttgttacgaa agaaacggga 1157221 ttggagctga tgtcacatgt gtggaattac gggttgggtc gattttaaaa agcagctcgt 1157281 ccaggaaaaa caaacgatgg acagaatgac agacactctt tccaaacgag ggcctgatga 1157341 ttcaaacgtt tggggggagc accatgtttt attcggacat aaaagacttg cggttgttga 1157401 tattgaaggc ggacgccagc cgatggcgtg tacctataaa ggcgatacgt acaccattat 1157461 ttacaatggc gagctttata acacggaaga tttgcgcaaa gaattgcggg cgcggggcca 1157521 tcaattcgag cgtacgtcag ataccgaggt gcttctgcac agctacatcg agtggcagga 1157581 agactgtgtc gaccatctca atggcatatt cgctttcgct gtgtgggatg aaaagcgtaa 1157641 tctgttgttt gccgcgagag accgtctcgg tgtaaagccg tttttttaca cgaaggaagg 1157701 ctcttcattt ctcttcgggt cggaaatcaa agcaatcctc gcgcaccctg atataaaagc 1157761 gcgagtggac agaacgggac tttctgaaat tttcggtctt ggaccgtcca gaaccccggg 1157821 cactggcata tttaaaggca taaaagaaat ccgcccggct cacgcgctga cattttccaa 1157881 agacggactt aatatttggc gttattggaa tgttgaaagc gaaaaacata cggacagttt 1157941 tgatgacacg gttgccaatg tcagatcgtt atttcaggac gcggtgacgc ggcagcttgt 1158001 gtcggatgtg cctgtttgca cattcctatc aggcggtctg gactcaagcg cgattacagc 1158061 gattgcggcg ggccattttg aaaaggaagg aaaagcaccg cttcatactt attcgattga 1158121 ttacgaagag aacgataaat attttcaagc aagcgctttt cagccgaatg atgacggacc 1158181 atggattgaa aaaatgacag aggctttcgg cacaacgcac cacaaatgcg tcatcagcca 1158241 aaaagacctc gttgatcatt tggaggaagc tgtactggtc aaagacttgc cgggaatggc 1158301 agatgtcgac tcatccctgc tgtggttttg ccgggaaatc aaaaaggact ttgtcgtcag 1158361 cctatcggga gaatgcgcgg atgagatttt cggcgggtac ccgtggttcc atacggcaga 1158421 tgttgagtct ggctttccat ggatgagatc aacggaggag cggatcaagc tgctttctga 1158481 ctcatggcag aaaaaattga atctgaaaga atacgtaaat gccaaatatg aagaaacctt 1158541 ggcagaaacg ccattattag acggagaaac gggtgtggat aaagcaagaa gacagctgtt 1158601 ctatttaaat atgctttggt ttatgacgaa ccttttggat cggaaggatc gcatgagcat 1158661 gggggcgagc ctggaagtgc gggtgccgtt cgccgatcac cggcttgtgg aatatgtttg 1158721 gaatattccg tgggaaatga aaatgcatga taatcgggaa aaaggcattt tgcgcaaagc 1158781 gcttgagggc attttgcctg atgacatttt gtatcgcaaa aaaagcccat atccgaaaac 1158841 acatcatccg gaatatacaa aaggcgtcag cgagtggctg aaaacgatca gaagccaaaa 1158901 ggactccgtg ctccatacct tactggacag aaaacaatta gatcagcttt tagaaacgga 1158961 aggctcctcc ttcaaggtcc cgtggttcgg gcagctcatg aaggggcctc agctgatcgc 1159021 ccatcttgct caaattcata catggtttga agcgtatcgc attgatattg acgagaggta 1159081 ggttcaatac aaatgtgatt aaaagccaga gatgtataga tttaaataag aaggatagat 1159141 gagcagggaa atatatgctc tatctatcct tttttgtaca acagcactat cgaattgccc 1159201 ccgcattcct tcaataagaa tgaataggtt ttaatgttct gccgataaaa ctagctgata 1159261 ccgggcttaa ctttaattcc ctagcccata cagaaagttg accaatatgg tgaatttcgt 1159321 gagcgatgat atggtgtaat atttcatctc gcgtatataa aacacctgtc tcccaaggaa 1159381 cgcttacaag ttcatctttt atttgatctg aatgtgtttg taaaacatca attatttcag 1159441 ttcggaatgt atttgagaga gatttcactt tattgagtgt ttgataatca gcgaactgaa 1159501 cagcgatatc ttcttttcct tggatagcac gaatccaact atattccaca tcaataatat 1159561 gaaaaagggt atataaaata ttctctactc cgccaagacg atttttaagt aattcttcag 1159621 tggttagttg atgacaccaa gtaaaccatt gatctctaac ctgccagtta tattcaaaaa 1159681 atttcatcac taaactcact ccaatactat catgtatcat aacaattagc ccttttttcc 1159741 gtgattcctc tattaatgaa gtgatgattg agaaatgttt acattctacc tgttgtatgg 1159801 cattaaaaat aataatgcat atctcgtcga tgatgctgtg cgtcttgtta cttttacaaa 1159861 gtaagaatcg gcattttctt catatacaat taggaaaaaa catactagac ttgaagaagc 1159921 agtgatacat aggagtgaga aaatgaaaga gataaaagaa gcttaccagc aatgcggaca 1159981 gattgttggc gaatacgcgc cagcctgttt caaagcatta tcatatctcc cgctaaagca 1160041 aagacaagcc tcttgggcag tattgtcgtt ttgccacacg gcggccagtg cagacgaaaa 1160101 ggtattgccc gcatttgaag ctaaagctga tcatgtttac caaaggacaa ataacggtaa 1160161 acaacatcta tggaaggctt ttgatcatgc gtatcggacc tttacattgg aaagcgaacc 1160221 ttttcgggag tttattgccg cacaaaaaga agacgccaag ccgtatgatg accttgatga 1160281 actgctcatg tacgcatatc ggacgggcgg tgctgccgga ttgatgctgc tgccgatact 1160341 gacacgccga aaacaagatc agctcaaaca agcagccgtc tctctcggct tggccataca 1160401 gctggttcgc ttcttaagtg atcttggcac agatcagcaa aaaaaccgca ttccccgtca 1160461 ggtaatgcag caattcggct atacagaggc tgatctccaa aaaggcaccg taaataaagc 1160521 gttcacaatg acgtgggagt atatcgcttt tgaagcagaa gcctaccttg aagagtgtca 1160581 ggatgccttg ccgctatttc cgcagtattc tcaaaaaacg gtgaaagccg ctcttcattt 1160641 gcaccgggct gttttagaaa aaatccgggc gaagcagcac gatgtatttc aatatcactt 1160701 cgctctcaca gagaccgaag tgaagcagat tctgtctgat atctaaaaaa cacccggcct 1160761 tgattgagcc gggtgttacg ccataccttt ttgaatccag atacgtgagc gccatcttct 1160821 gtacattaag attccccgga cccattcatc cgcgataaaa gaaatccaaa tgccggcaag 1160881 accgaaaccg aggtggatgc cgaaaagata agcaagcggg aggccaatgc cccacattga 1160941 aatcattgcc atgtaaaccg ggaatttcgc atcccccgcg gcccgcagag agttaatgat 1161001 aatgacatta aacgagcggc ctggttcaag gataatggtc atggcaatca ataggcttgc 1161061 agttgctata atgtcagggc tttgtgtgaa gagtccgatc aggtcttttg aaaagatcgt 1161121 catcaaaaca gaggtagccg cagcaattcc gagtgcccaa tataagctct tcatgcagcg 1161181 ctcataagcg gcatcaaatt gtttgccgcc gatataacgg ccgattaaga tttgtgtacc 1161241 ctggctgatc gcagtgccga acagcaaaat aaacatcgta atattttgcg tatacacttt 1161301 tgttgtcaac gcctgcgcgc ccatgatggc gataaaatac gtgactatca tttgcgacag 1161361 gttgtatgaa agctgctctc ccgcagaagg aatgccgatt ttcagcagct tgcgcaaatg 1161421 ctctttatgc atatgaaaga cttttttcag cgacatcttc agctggatgc gtttgttgac 1161481 aatcacaatc atcgcgatta atccgatgac gcgggcgata gatgtggaca tggccacacc 1161541 ggcaacaccg agaacaggaa agccgaacaa accgaaaatc acaacaaagt ttccggcaat 1161601 gtttaaaatg ttcatgccga tagtgacaaa cattgtatct tttgtgtagc cgtagctttt 1161661 taagatcgcg ctgaatgtca tgattaaagc ctgaataaag gacagacctc cgacaacttg 1161721 taaaaagact ttcgcatcag gcatcagtgc gtctgataat cccatcatat gaagcagagg 1161781 gacagccgcg aaaaagacga cggcgctgat ggccaggctg atgaagaagt tggcgccgat 1161841 tgacacataa gcgacttcca tggcttcttt cttttgccgt gagcctagaa attgtgaaat 1161901 gataacggtc gttcctgttg cgataaagct gaacatcacg ataattaaat ttaaaatctg 1161961 gttgctgacg ccgactgctg ccacgctgtt atccgagtat tggctgagca tcagtgtatc 1162021 ggcattaccc ataaacatat ataatgagac ctcaataaag atcggccaag taagcgaaaa 1162081 taatgagaac gttttgtcag cgggtttttt caaagcagtt gatttgaaga cagcttgttt 1162141 catcgtgtct aacccctttc gtaaataaaa tcaacgtttt aaagtgtacc tccatttcct 1162201 tataataaaa agggatagaa acgatacttc ttgtaaaaat ccgacttaaa aaggaggatg 1162261 attcaaatgc ctcgcatcct gtttacagtc ccgccttttc cggtatttat cgcagctggg 1162321 gaaggggttt ttaaaaaagg agaaacccat gtgaaacgtg tattctccgt gtttgatctg 1162381 atatatgtca aacagggaac gttatatata acggaaaatg aaacatcgtt ttctgttgaa 1162441 ggcggcgagt acatcttgct ttctcccggt cttgaacact acgggacgaa gggcagtgat 1162501 gaagcaacct cctactattg gcttcacttc gatgaacatc gatatgaatt tacggcaaag 1162561 ggaggcagca actggtctga gcttcagcag gaaaaaggga gcttcgaaga gctggcccgc 1162621 tacggattgg ccttgccgag aaaaggcaag gtgcagcgcc cgcagtttat ggcgcagcag 1162681 tttgaaaagc tgatcgatta ctccgcggaa aactctgatt tgccgctcag aaagcaaatt 1162741 ttatttgagg agctgatgct gcatcttcaa aaagaagcgt tccaaatacc gtctgcgaaa 1162801 gagcgggtag cctgggaggc ggcccggtat ttacaggagc actataagga aaagacgaca 1162861 atcaaggatc tgtcgctcgc ccttcactat catcaggatt atgtgagccg ctgcatgcag 1162921 caggtgctcg gcgtaactcc ggcacaatac acgaaccggg tgagaatgac ggaagcgaag 1162981 cgtcttttat cctctacaaa tgataaaatg ggcgttattg cggaaacggt cggaatggaa 1163041 gatccgacat acttttcaaa actctttaag cagatagaag gcatttcacc aattgaatac 1163101 cggaaaattg tcagccggaa agttcaataa ccagacgagg gatgaacatg aaaacaacaa 1163161 tttacgatgt ggcaaaggcg gcgggtgttt cgatcacaac tgtgtcccgt gtgataaaca 1163221 atacggggag aatcagcgat aaaacacggc agaaggtcat gaatgtcatg aatgaaatgg 1163281 catacacgcc caatgtccac gccgcggcgt taacgggaaa acgaacgaat atgatcgctc 1163341 tcgtggcgcc tgatatttca aatccgtttt acggcgaact ggccaaaagc attgaggaaa 1163401 gagcggatga gctcggtttt caaatgttga tttgcagcac cgattacgat ccgaaaaaag 1163461 aaacaaagta tttttctgtg ctgaaacaga aaaaggtgga tggcattatt tttgcaacag 1163521 ggattgaaag ccatgacagt atgtctgctt tggaggaaat cgccagtgaa caaattccga 1163581 ttgccatgat ttctcaggat aagccgcttc ttccgatgga tattgttgtg atagacgacg 1163641 ttcgtggcgg atatgaggct gccaagcatc ttctgtcact cggccacacg aacatcgcct 1163701 gcattatcgg agacgggtca acgacaggcg aaaaaaatag aatcaaaggc ttccgtcagg 1163761 cgatggagga agcgggcgtg cccattgatg aatcacttat catccagacg cggttttcct 1163821 tggaaagcgg caaggaagaa gcgggaaaat tgctcgacag aaatgctccg actgctattt 1163881 ttgccttcaa cgacgtattg gcttgtgccg ccatacaagc tgcgagaata agaggcataa 1163941 aagtgccgga tgatctttct atcattggtt ttgataatac gatactcgca gaaatggcgg 1164001 ctccgcccct gacaaccgta gcccagccga taaaagagat ggggcggagc gtcatcgaac 1164061 tgctggcaga agcaatagag ggaaaacgaa aggcgaaaca aaaaatagtg ctcccgcctg 1164121 agcttgtagt cagacattct acatcaccgc tcaacacatg agcccgctaa tgagcgggtt 1164181 ttttcattat gacagttgaa gccaaaaaaa catattgcgt gtaaaccaaa ggcggtgtaa 1164241 aatataacca tcttttgaga aagcgcttgc gcaaaatggc agagcggata gaaccgctgt 1164301 ttttttagct gttaagagaa aacgctttct caaagcgagc ccgaaatgag ataaaggaga 1164361 ggatgggacg tggaacatca agtaagatgt gcagtattgg gattaggaag gctcggttat 1164421 tatcatgcga aaaatctcgt caccagtgtg ccgggggcaa agctggtttg tgtcggtgat 1164481 ccgttaaaag ggagagcgga gcaggttgcc agagaactcg gtatcgaaaa atggtcagag 1164541 gacccgtatg aagtgttaga agatcccggc attgatgctg tcattatcgt aacgccgaca 1164601 agcacacatg gtgatatgat catcaaagca gccgagaacg gcaaacagat ctttgttgaa 1164661 aaaccgctga cattaagcct tgaggaatca aaagcagctt ctgaaaaagt taaggagaca 1164721 ggtgtcatct gccaagtcgg ctttatgaga cggttcgatc ccgcatacgc agatgccaaa 1164781 cggcggatcg acgctggaga aatcggcaaa cctatctatt ataaaggctt tacgcgcgac 1164841 caaggcgcgc ctcccgcaga atttatcaaa cacagcggtg gaatttttat cgactgttcc 1164901 atccatgact atgatattgc ccgttatttg ctaggggcgg aaatcacttc tgtttcagga 1164961 cacggcagga ttctgaacaa tccgtttatg gagcagtatg gcgatgtgga tcaggcgctg 1165021 acgtatattg aatttgactc gggcgcagcg ggggacgtcg aggcaagcag aacctctcca 1165081 tacggacatg acatccgggc ggaggtgatc gggacagagg gcagtatttt catagggaca 1165141 ttgagacatc aacatgtgac catcctatcg gctaaaggga gcagttttga tatcattcca 1165201 gactttcaaa ctcgttttca tgaagcctac tgcttggagc ttcagcattt cgccgagtgt 1165261 gtccggaatg gaaaaacacc gattgtgact gatattgatg cgacgatcaa tttagaagtg 1165321 ggtatcgccg caaccaattc ctttcgaaac ggcatgccgg tacagctaga tgtgaagcgc 1165381 gcttatacag gtatgtaaaa gctaagtatg ttgcatttga ggctttccgc aaaaaaagca 1165441 agggcatttt agcccttgct ttctcttttc tcatataaat agtacatata atcagtaggt 1165501 acgcctgaat ggtccagctg tctcagcatg gcggttacgt tccctctgtg gtaagtgccg 1165561 tgattgacga catgcaggat ggtgtctgca taggttgatt ccagtgtacc tagtttcgga 1165621 tgctgcattg tgaaggtctg ttctaagtcc gtctggcggc tgaagaaatc atgatactgt 1165681 gactccagct cggcagcgtg ctgtttaatc gctgccatat taccttgcgc ggactgtaat 1165741 ttgcctgcgc tgtctataat ctcttggtag gccactcccg aaagaacatt cagccaaatg 1165801 tagtcagccc tgcacatatg aagcagcacg tcgctgacag aaggaaatac gctctttact 1165861 tcttgatagg cagtttcctc cggcaggttt tcgatatggg taaatatttt cttgtttgcc 1165921 caagaatgat agtcataaaa ctgttttgca tcagtcatca gcatgccccc ttttctaaga 1165981 aattcgtttt tttcatctgt ttctccttca attgcaaaag agtgacaccc caaaatatcc 1166041 tgccgctgcc cacattaccg ctgcagagca tttgtttacg atcagcataa gcctgccgct 1166101 cgtatctatc gtctgaaaca accggcccgc tattgcaagg ctgatgaacc aaatccaaga 1166161 cacagcgatg caggcggcca taaagagcca tttctcaagc cccgaatatt gaagagagct 1166221 cgtgccgatg acgccgatcg tgtccagaat ggcatgcggg tttaaaagag aaacagcggc 1166281 cgcaaacgca gcttgctttt ttggtgtgaa cgtatgtttc tcattttggc ttgtgttcgg 1166341 acggatgttc caagtcaccc agcccatata aagcaaaaat aaaaatccgc cggccatcat 1166401 gactgtctca aacacaggca gctcctgcac aatgacagac acgcccgcaa cggctaatac 1166461 aattaacaag gtatcgcaga ctgaagcact gatgacagct gggagagccc gccaaatatg 1166521 cttttgcaac gcgccttgct gaaaaataaa cacattctgc actcccagcg gcaaaattaa 1166581 gccaaacgcg agcacaattc cgtgaatgat tgcattcatg ctgaaaaagc tcctttcaca 1166641 ttttttttca atcataagag agattgtcac taaagtctcc agccatttgg ttgggttagg 1166701 aaccagccaa atgtataatg tgtaaaaaag gggggcatga ccttgtcgca atggcagcca 1166761 agccgaaagt cggatgttcc gctgcatcgg cagatcgaac aatatatgaa agacaagatt 1166821 cttcacggag agtgggctgt agggacgaaa atcccctcac agagaacgct ggccgacatg 1166881 tttcaagtca accgcagcac agtcacagca gccatagatg aactcacgtc tcaaggcttg 1166941 ttagagggaa gaaaaggcgg cggtacgaag gttgtaaaca gtacttggag cgtgctgacg 1167001 gctgagcctc cgcttgattg gagcgattac gtccgttcgg gcattcatcg cgccaattct 1167061 tccatcattc aagctattaa tcagaacgaa ccaagagcgg atatcatcag attaggaact 1167121 ggagaacttt caccggatct tgtgcctgct gacacaattg gacggatgtt tcagcaaatc 1167181 aatccgggcg tcctgtcttt aggatatgag cagccgaaag gaaaccgtca gctgcgggag 1167241 gcagtggccg accatttaaa aggaaagaag atccatgtgt caccgtctgc aattttaatt 1167301 gtgtccggtg cacttcaggc acttcagctc atctcaattg gacttttaaa acgagattct 1167361 gtcattttga cggagaagcc gtcctacctt caatccttgc atgtatttca atcagctggg 1167421 atgcggcttc gcggcttgcc gatggatgat gaaggggtca aagcggggct tgtttcttct 1167481 aatcgaaaac aatatggagg acagctgctt tacacgattc cgtcgtttca taatccgaca 1167541 ggcacagtca tgtcagagca gcgaaggaaa gagatcatca gcctgtcaaa aaaagagcag 1167601 atgcccatca ttgaggatga tgcgtacggt gatttatggt ttgaagaaaa accgccgcag 1167661 ccgttgaaag caatggatca tgagggcaat attctgtatc tgggcgcgtt ttcaaaaacg 1167721 gttagccccg gtctgcgaat cggctggctt gccggtccgg agccggttat tgaaaggctg 1167781 gcggacatta aaatgcagac agactacgga tcaagcggcc tgtcccagtg ggcggctgcc 1167841 gagtggctgt cacagggata ttatgaagag catctgactt gggtacgcag gaagcttaaa 1167901 gaaaggagag acgccgccgt tcattttctc gagcggtatg ccggggacat tgccacgtgg 1167961 cggattcccg caggcggctt ttatatttgg gtgacatttc acaaaaacct gcctgtcagc 1168021 cgtttctttt atgaattgct gaaacggcag gtgcttgtga atcccggcta tatttatgac 1168081 ggtgaagacc gaaacagcat caggctgtca tattcctatg catctcttgg agatttggaa 1168141 actggcatta aagcggcagc tgaaacagca cgccgcctga tgatgtccta ggctttggtt 1168201 atacgatgac agctcccagt gccctggcga aggcaatcgc gtgctcaggt gcgattttgc 1168261 agcctttcaa tttgtcgagg gagacatgaa gctgttcaaa acggcacgtg ctgatgtcca 1168321 tgttttgaag ggacgtgccg gtaaagctgg cgccttccaa ttcgcatccg tcaaagtgtg 1168381 tctgctggag caccgtatcg ctgcattcac tttgcataag agcacagtga tcaaatcgaa 1168441 cttgtttcat atttgagtac gaaaatgagc tgaaatgtcc gtggcattcc tcgaatgaaa 1168501 cattccgcag cgttgcttcc gccacattca ttccaaccat ttttgactgc ttaactgaag 1168561 ttctgtgaat gacagccccg ctgaaatcgg cgtttgataa atcgcatttt tcaaagatca 1168621 catcggtcag ttcaatatgc cgaaaagaca catcgataaa gacgacattt ctgaataccg 1168681 ttttttcaac acatagtctt tcgatatctt cgccgcagat ggtgcaatct tcaaacaaat 1168741 gcatgctgat tacatcatcc tgtgtcacgg catcatgaaa atctgcggtt tgcaggtttt 1168801 ccggtatgtt cggtttttga attgcgattt tattcatgtg atgacatcct ttgctgcccg 1168861 aaaaacagag gcttccgggt tcaatttaat agatcgttaa ggaaattgat acatatagta 1168921 aatcgtgaag agccttttct tggtacagca gcccgcttgt tttgtaagca taaatggaaa 1168981 gcttcctata cgtcaaggcg tttacaggcc gaaaaagcca aagggaacag gaggaatgcg 1169041 gaatggggca ttacatcaaa accgaggagc atgtgacact gtttgtagag gatatcggac 1169101 atggaaggcc gatcatcttt ttgcacgggt ggccgttgaa tcataagatg tttgaatatc 1169161 aaatgaatga gcttccgaaa aggggatttc gttttatcgg cgttgatttg cggggatatg 1169221 ggcaatctga ccgcccttgg gaaggctacg attatgacac gatggccgat gatgtgaaag 1169281 cagtcattta tacgctgcag cttgagaatg cgattcttgc cggtttttca atgggcggcg 1169341 caattgcaat ccgttatatg gcaaggcatg aaggagccga tgttgataag ctgattttac 1169401 tgtctgcggc ggcccccgcg tttacaaaac gcccgggtta tccgtacggg atgaggaagc 1169461 aggatattga cgatatgatt gaattgttca aagctgatcg gcccaaaaca ctggctgatt 1169521 tagggaaaca gttttttgag aaaaaagtgt ctccagagct taggcagtgg tttctcaatc 1169581 tgatgctgga ggcttcctcc tacgggacga tccactcggg catcgcatta agagacgaag 1169641 atctcagaaa ggaacttgct gcaatcaagg tgccgacgct gatcctgcac gggagaaagg 1169701 atagaattgc gccgtttgat tttgcgaaag aattgaagcg cggcatcaaa cagtcggaat 1169761 tggttccgtt tgcaaacagc gggcacggag cattttatga ggaaaaagag aagatcaaca 1169821 gtttgattgc gcagttctcc aactcataag aaaaaacccg acattgatcg ggttttttat 1169881 ataattcctc tgttttgcag tgcgttaatg atgagatcag ctccatcgga aatagaggtc 1169941 tggtcagact caatgatgaa atcgggtgaa agcggcgctt catacggaga atcgatcccg 1170001 gtgaaatgtt tgatctctcc gtttcgcgct tttttataaa gcccttttgg atcgcgctgt 1170061 tcacaaacat gcagcgggca cttcacataa atttcgaaga actcaccttt aggaaagagc 1170121 gctctaacca tgtcccgatc ctctctgaat ggagaaataa aagccgttaa aatcatttgc 1170181 ccgctgtcga caaacagctt cgccacttct ccgatccggc ggatgttttc aatcctgtca 1170241 ccagtctgaa atccaagatc tttgtttaag ccgtggcgga tattatcacc gtcaagcacg 1170301 tagctctgaa tgcccttgcg gtaaagcttt tcatcgacag cattggccag caccgatttt 1170361 ccggagccgg acaaacctgt aaaccaaagg acgcagcttt tgtgtccgtt taaggactgt 1170421 ctgtcagact ttgagatggc agcgggatgc caaatgatgt tcggattgtg tgtcattgca 1170481 attccccgct gttttgcttg atggcaacag gctgttggtg aagtcccttg atcagcacgg 1170541 ctgcgacctc aggccggctg aattctttag gcggcttttt gccttggcgg agaagctctc 1170601 tcacttttgt gcctgataag tggatgtggt ctctcgggct gtgcggacat gttttggagg 1170661 tgcccatgtt tccgcatttt cggcaataaa agctgtgctc aaaaaacagc ggcttgatgc 1170721 ccagctcttc ctctgtgaat gattgaaaaa tattttgggc gtcgtatgtt ccatagtagc 1170781 tgccgacacc cgcgtgatca cggcctacaa taaaatgggt acagccgtaa ttttttcgga 1170841 cgagcgcatg gaaaatcgct tcccgcggac ctgcataacg catggcggca gggaaaaccg 1170901 ataacatgac acgatccttt ggataatagt gattaagcaa agcctggtag ctctccattc 1170961 tgatatcgct ggggatatcg tctgactttg tttctccgac aagtgggtga agcagcagac 1171021 cgtcgaccgt ttctaacgct gttttttgaa tgtattcatg cgctctgtga acagggttcc 1171081 tggtttgaaa gccgacaatc gtcttccagc cgagtttttg aaaggccgct cttgtttcag 1171141 cgggcgttgc ataaaactgt tcgaaagatt tgtcaggcag gctgctgacc gtgataggcc 1171201 ctccgatata gtaatccggg cgcgccagca atttttttac gcctgggtgg gcaggatcgt 1171261 ttgttttaaa aacagacagt gcttcttgtg ttttatcagg ctggtatata tcggtgactg 1171321 tgatcatgcc gtaggtaaca ccgtctttca caagcttgac gtgatctccg gcagacagct 1171381 gtcttgctgt tttttctccg acaggcagcg taatcggcag gctccacggc aagccgtttg 1171441 ccagcctcat ctctttcaca acggaatgat aatctttttc tcccaaaaaa cctgttaacg 1171501 ggctgtagcc gccgatcgca ataagctcca gatcactcag tgcaagctga tccagctctg 1171561 cttggcacgc gcacccttca aaatggcatg cgggatcaca gcggttgatt aatacccctc 1171621 cgtggggttc gtttccattc aacgtgttca acctccattt atacgtttcc ttgttttctt 1171681 ttctgcactt aatgaaagtt tgacatcagc gccttaacat catttcgatt ctcacatcaa 1171741 gaacctgcca tccgctattc ttgatgcagg ccgcattctg ttttctcccg tccggcccat 1171801 cttccagccc tctcatcgtt cgggtccggg gaaggcagtg tacacatttc acagcctatg 1171861 ctcggataat gttgatcgtg cagtttgtta taaggcaaat tgtgcaggcg gatgtacgtc 1171921 caaacgtcat cccatgtcca gtggataagc gggcaaattt tgatgagctc aaacttctgg 1171981 tccaggttta cgtattgaat atgctttctc gttggtgact gatcccggcg cagtcctgaa 1172041 atccaagctg tcatgccgga caggtgcttt ttgagcggtt cgattttccg caattggcag 1172101 cagaggttcg ggttatgctt ccacagctct ccgccgtact tcgtcccctg ttctgttaag 1172161 ctcagctcgg gttcgagcat ctggattgca aatcccggat atcgttcttt gacggtctcg 1172221 atcagctcat atgtttcctg aaaatgaagc ccggtatcca aaaagatgat gtgtgcgttt 1172281 ttgttgattt ttgatattaa gtcgagaagc accattcctt ctgcgccaaa gctgcaggcg 1172341 tacacaatct tttctccgta cgttcggtaa gcccatttca acacatcgag ctcatcgatc 1172401 aattgatccg ttatctgttt ggacagcatg tcgttccaag tgtcatatgt gatggtttcg 1172461 ttcaatgttt tccccccgtt tgcatctgct ttttttatct attgatcgag ttataggcag 1172521 actattcatt ttttgcataa aggttcaggt tttaggtgcc gcgcccgcct aaaatgaggt 1172581 gcggaaccat taagagcccg gctgaatatg ctttttagca aaatggtttt atgcccaagg 1172641 agaggtagta tgccgattgc catttatcag gggcatcatc attcgcttgc cccggcggac 1172701 attaacatcg tcattgatgt catcagagcc tttacggtcg cccattatgc gtttatcggc 1172761 ggggcgaaag agattttgtt ggtccggaca gctgatgaag cctttgcgct gaaagacacc 1172821 tatccggatt atgttttgac gggagaggaa aagggggtcg gtatcagcgg atttgattta 1172881 gataattctc caaaacgtat ggctgggcag aatatgacgg ataaaagcct gatccagaaa 1172941 acaacaaacg gcgtcacagc agcattgggg gcgctgaacg caaagcatct gttcgtaact 1173001 ggattttcca atgccaaaac aacggcacag catgtgaaaa agctcgtcgc aaacgattgt 1173061 gtcataaaca tagtggcttc ccatccatcc ggtgatgacg atatggcatg tgcggagtat 1173121 atcaaaggca tcattgaagg gacaaatgtg gtaacggctg cggaggcgat tgaaagaata 1173181 aaaggctctt ctgttgcgga gaagtttttt gactgccgcc agccattgtt tgattcggaa 1173241 gacatcgttt actgtacaaa agaactgacg ggcgatttcg tgatgaaagt gaaacaagat 1173301 ggagaagttc caacgataga gagggtcata atatgaatga tttttcacta gaattgccag 1173361 tgagaacaaa caagccgaga gaaaccgggc agtccatttt aattgataac ggctatccct 1173421 tgcaattttt caaagatgcg atagccggag cgtccgacta tattgatttt gtgaaattcg 1173481 gctggggcac atcattactt acgaaagatc ttgaagaaaa aatcagcaca ctgaaagaac 1173541 atgacattac atttttcttt ggcggcacac tgtttgaaaa gtacgtaagc cagaaaaaag 1173601 tgaatgaatt tcatcggtac tgcacctatt tcggctgtga atatattgag atttcaaacg 1173661 gtacgctccc gatgacaaat aaagagaaag cggcttacat tgccgatttt tctgatgaat 1173721 ttcttgtgct cagtgaggtg ggcagcaagg atgcggaatt agcaagccgg caaagctctg 1173781 aggaatggct tgaatatatc gttgaggata tggaagcggg cgcggaaaaa gtgattacag 1173841 aagccagaga aagcggaacg ggagggatct gttccagcag cggcgatgtc aggtttcaaa 1173901 ttgttgacga catcatttcc tcggatattg atatcaacag gctgattttt gaagcgccta 1173961 acaaaacgct tcagcaaggg tttattcaaa aaatcgggcc gaatgtgaat cttgccaata 1174021 ttccatttca tgatgccatc gcgttggaaa cgctgcgttt agggctaaga tccgatacct 1174081 tttttctgta aaatagcggc tgcggggctc tcgtcgtgaa gagagcctct gcctattatt 1174141 ttttatggcg gtacataggc gtgagatagg gaagtgaggt caggcggatg ttgtagatga 1174201 agtcgatgac tcttgtcgat atcacctggc atatgagggc ttgaatgacg atgccccagt 1174261 caataataga cgcggtgacc ataaaaatga tgcaattcat gatgagcagg atcgttccag 1174321 gattcccgcc gcggtagata gaaatcatca gagcaagggc tccgaatcct ccgttcgaaa 1174381 ttttatattt gtataaaagt ccgattccga gtcccaataa cactgcgccg cttgccagat 1174441 caagccacag gttagatgtg atatcaggaa aaactgcatc aaagatcaat accgagacag 1174501 aggtgacggt gatagaagcg agggtgccgg tgaatgttct catctccagc cattttaaag 1174561 cggtaaaaag cattgataca ttcacagccc acactgaaaa tccgtggggg atttgaaaca 1174621 gataatgcaa tagcaccgca atacctgctg caccgcctgt cggaatatca tgcggaaata 1174681 aaaacaagga catgccgagt ccttgtagta cgccgcctac gacaatcata aacgtaagtt 1174741 ttgctttcat cagcagttca gccattaagt catttgctcc tttatgaaaa gacttgtccg 1174801 ctgttttcat tttatgaggc tgtccattat ttatgtctca aaataaagaa atggcccagc 1174861 ttaataggct gagccatccc acttgtagcg attgacgatc tccatattga tctctgtgcc 1174921 aatgcctttt cctttcggga tgtggaccat tccttttgaa ggctgcaggc tgacgagatc 1174981 tgtaaaagga ttctccatga cgtcccactc gatcggttca atgtgatcgt tcttcatttt 1175041 agaccatggg ggcagacagg cttgtgcaaa taaagcatag agccgtgaga gcgatccgtc 1175101 atatgcatgg gcggatgctc tgacgccgaa ataacgcgcg agctggaggc agtcccgaaa 1175161 ctcatcaatt ccgttgacat gcatgacatc gggctgaatg atatccaaac agcgctgtga 1175221 aaggagaggc acatattgcg ccgggccttt catgttttct ccgccggcaa caggaacaga 1175281 caaacggctt cgaagcatag cgtaatcctg cggctgatca aagggcaaag gctcctcaag 1175341 ccagccaatg ttcgtccatt cggagaaata gcgctcccat ttaaaagccg cagcggcatc 1175401 gtagctttgg tttgcgtcca gaatcatcgt aatggagctg cctgctgtat gctgcagcgc 1175461 attgatgtgc cggacatcct ccttgaatga agtcccgcca attttgactt tgatttgctc 1175521 aaaacctttt ttcaactggg cttcaacatt ggagactgag cggctgatcc attgcgggga 1175581 gtctgagtac gattgaaaag acgcgtacac aggaatctcc tctctgtatc gcccgcccca 1175641 taattcgcaa accgaacaat ccgcagcttt ggctgcaatc tctgtcagcg ccatgcttac 1175701 agcggaggcc gcccgctggt gccatttttg aatcgtgcgc actaatgaca ggcggctgcc 1175761 agcctgtttt cctaatagaa atgggatgat ccgcttcgta aaaccgacat ggagagcagg 1175821 gagccaatca acgcattctc cccagccgtc tatcccgctt tcggtgataa tcctgatgag 1175881 ataacaagtc cgatatcgtt taaacccatt ggcatctccg tatggctttt ctaatcgatg 1175941 aaatagcgga aaggtttcaa tccgtacaat tttcacactg ggtgctacct ttcctcagcg 1176001 ggctggagcc gattgccagc cattttaggg tcttcttttt cttttgtttc ttcattgttt 1176061 tgcttcacat ggatgagcat catcacaaga atcccgacaa cgagagtcaa tcccgcgatg 1176121 cttaaaaaca tgccgggtct ggaccattgc atcaggcggc cgaaaatcgg aggaccgatc 1176181 gctaccccta agaaacgtac agagccgtac agcgaggtga caaatccccg tctttctttg 1176241 ccgacagccc cggtaatgaa actgttcaca caaggaagga caagacctga gcctatactg 1176301 ctcagtacaa gaacactgat aaaaaggaca agattttcaa tgaatgacag tgccgcgtag 1176361 gatacggtca tgaacgccaa tccaagtacg atcagctttt tcattaacga ttgcttttgc 1176421 ccgattttgc ttcctgttgt ataggacgtc acacacataa ccaaaagcgg gatcgctaaa 1176481 attaagcctt ttttcacgcc gtcggtgtcg tatgtttttt caagaacatc tgagagataa 1176541 aacaggatgc cgaataaagt aaacaaacag gtcgcaccgg ctaaataagc ggtaaacagc 1176601 catctgcctt catgtttaaa gacacttaac agcccttttg catattgtcc gattggtggc 1176661 ggttcttttt cctttttctt ttctttaata aaaatccaag tcagtacgat cgaaatgata 1176721 caaaacacag gaaaggcaaa aaacgcgcca taccagacaa gcagggcgat cagcgagcca 1176781 atgatcggcg atagcacttt ccccatgccg tttgaagctt caacaaggcc gagcaccttg 1176841 ctctcctggg cgcctttaaa cagatctccc gtcagtgcca tggcaattgg gccggttccg 1176901 gctgccccga ttccctgtaa cgctcgtcct gccatgaccc aaggataggc attgtcaaaa 1176961 aaacctgccg caaacccggc taacaaaccg ccggcaccat acaaaattaa gcagggaata 1177021 atgatgactt tccttgagaa tcggtctgcg agataaccga caatcggaat cgcaaatgct 1177081 gcaatcaagg aaaatactgt gatcacgaga ctgacttgaa attgtgataa atgaagttca 1177141 gatttcattt ttggcaaaat cggaataagc atcgagtttc ctagggttaa tattaaaggg 1177201 attgaaccga ttgccacaat cgtcattccg ttattttgtt ttgatgattc catctcagag 1177261 cacactcctt ttcttctgct tagaatgtcc ctgatggctt cgtttattca gcgatcagac 1177321 agcaaaaaac cgaacagaag atacctgttc gggaaaaaag agggttaacc gagagcctgt 1177381 gaaatcaaag catataagtg tccattttga ataggcgctt ttttctgata gaacaaaatc 1177441 ggaggttcat catctttatg aaatcccatt tctatcaggc tgtcatgcag agacgtgtgt 1177501 tcactcggta tatcgattcg catcggccct tgtttgccgg ccgccagcct tgtaattatc 1177561 tgtgctgcaa catctgatga tggagcgatg atagggccga atttcaaatt ggccggtgtc 1177621 tgtacagaaa gtccgtagcc aatgagctgt ccgtcctgat ttctggcgat gatacattcg 1177681 catgaagcag aaataagctg ctgcaaaagg tttgatcgat ctccgccaaa ggcagccaga 1177741 tccgccgcgg ttaagtcgtg aaagtcttgt tctctaaagg atgtcagttc agcatcaagc 1177801 ttttttgtat aaggttgaaa actgtgacag ctgtactttc gcactgaacc tgccgtatga 1177861 aaacctgctt tttcataaag cggcaaacct tcttttgtgg cgcaaagcct gatggcggtg 1177921 ttttcatccg tttgggtaat acaggcgttt accatacgcc ggccaagacc gagccgttga 1177981 tattccttgt caacgataac aaggccgata gaagtaagac ggccaaacaa aaacaagccg 1178041 atgcaggaaa taatatcacc gctgacattt tgataaccga aaaagcgtcc ctgctgaaca 1178101 agcagtttca gctcttgttc gccataatcc ggccacccgg cttgcccgca aagccgcaat 1178161 aagccggaaa cgtgttcttc atgaagctta atcagttcat ctactacgtc cataagatca 1178221 cctgcttgtt ctaagtgttt tgtacatgac aatatgattg ccaatgccgg gaatgtcaaa 1178281 tggttcgcca agttccttcc agccaagctt ggcatagtag cccttgacat ggtgtcttgc 1178341 gttgcaccat accgcctgaa cgccgctctc cgccagtttg tgctccgcgt gtttgatcag 1178401 cgtgcttcca gctttttgat cgcgatatcc ctcgagcgtt gccatgcctc tcagccgata 1178461 cgcagaggct tccgttaata aaggctgact ttgcggggaa aaagaagcga tgctgatcag 1178521 cgttccatca taaaacacgc cgagatgaaa ggagccttct gcgtgatcct ctttatattt 1178581 gcattgttcg atggattgat ggggacgcag aatgcgatgc cggatttcat atgtatcttc 1178641 cacggaaatg gttttgactt cgagcataat gttcctcctc atgattgttt ttctatatcg 1178701 taacacgaat ctcgttgaaa aagactgccc gattcgatca ggcagtcttt tggaaattaa 1178761 tgcaaaaaga tattttggcg ctgctcatct ttttgctgaa tatatgatgt gagctcagcg 1178821 gttaagtcag atctgaggaa aggcgttatc aagtagatgc cgttaaacag ctcgcatgcc 1178881 gtatccagca gggagcgtgc aattgcaagg ccttccgcct tttgcttttc tttatcttca 1178941 ccggcatggg ccattttttc gcgaatcgta tcagacagct taatgccggg aatttcatta 1179001 tggatgaatt cggcattccg gctgcttgtc agcggcatga tgccgatata gatcggcgtc 1179061 ttcagatgtt ttgtttcgtt atggatatcg acaagctgct gctcggaata gacaggctga 1179121 gaaacaaaat aatctgcgcc gcaatctatt tttttctcaa gccgttttac cgctttatcc 1179181 agatggcgga cgttaggatt aaatgcggcg gcaactgaga aattcgtttt cttgccgagc 1179241 ggttttccag acagagacag accttcattg aattgtttga tcagcctgat taaatcaaaa 1179301 gatgttaaat catatacaga cgtcgcccca ggaaaatccc cgattttaga agggtcacct 1179361 gtaatagcaa gcacgtcatt cagccctaac gtatcaaggc ccattaaatg tgactgtaag 1179421 ccgataatgt tacggtcacg gcacgtaata tggacaaggg aacgcatatc gagctgctgc 1179481 ttgacaaggg cgccgcaggc aacattgctg atccgcgggg tcgccaaaga attgtcggcg 1179541 agtgtcaggg catcgattcc cgcttctttt aattcagcag cagcggacag aaatttgtca 1179601 aagcttagtt ttttcggcgg gtccagctct acgataatag agcgtttttt cgctgcgatc 1179661 tcatccaggc cgggctcggt tcgctcgtga tgaacagaaa tgaattcttt cgcccgggtt 1179721 ttgacttctt tttccgtaat cggagccagc ccgccaaccg cttccgccat cgccctgatg 1179781 tgattcggcg ttgtgccgca gcagccgccg ataatccgcg caccttgctt acggaattct 1179841 gacgcgctgt tttgaaaata cgtgtcgtct gtttcataga cgagccgtcc ctcttcaagc 1179901 gaaggaagac tgctgttcgg ataaacggat aagaatacgt catcaaaaat cggcacttcg 1179961 cttagcgctt caatcatgtg ataagggccg aggcggcagt taatgccgac aatatcagct 1180021 ccgagatccg caatcgagcg caatgcgtca gaaagcggcg ttccgtcctg caatacgcct 1180081 tgctcgtgca tggagacatt gagcataatc ggaagatcag tctctttgcg cgcgattttc 1180141 agcacttcac gggcttcttc caaatcataa tatgtttcta acagcaagcc atccggctct 1180201 tcatgcagca gcagatacag ctgctcgcgg aagctgcgct taatttcgtc aagactgtat 1180261 gcgtttttat taaatgtgcg tatgccgccc atcgttccaa gcacgtatgc atcgcctgct 1180321 gaagcccgcg cgatctttac ggcctcctga ttcatttttt tgatgtcatc ctcaagcccg 1180381 tgtctggata atttaatata gttggctccg tacgtattcg tttgaataat gttggctccc 1180441 gcttcaacgt acgctttatg tatgcgctga atttcctccg gctttgaaat attgagctcc 1180501 tcaaaacacc tgtcaatgcc ataggagtag aggagcgtcc ccatggcgcc gtcaccgatt 1180561 aacacctgtc tttgcaaatc ttctaaaagt cccattgtct gcctccttta ttcacatcag 1180621 caaggaaaaa agagaaataa aaaaagtcct cttaagaaga agactttgtc agtgattttg 1180681 tctcttctta tcttccaagc tgttcgagct tgctggattt agcaccttgg tcatggctga 1180741 tcgccattac accggttgct gaagcttcgt cgggccagtc cctctgcttc tcttgataag 1180801 aacggatatg aaattttcgt gtcaggaagt gccaaaagat atctggcgtt tttccctttc 1180861 tccaaattta ccgaaaataa agacaataat caataggaat cagaaaattt atctgaaatt 1180921 tataaattga acgtcaattg gcagatctgc tccccgtaca gctgagataa tctgctgcag 1180981 gtcatctttg ttttttccgg tgacacgcac ttgatcatcc tgcacctgag actttacttt 1181041 cagtccggag tttttgatga tcgtattgat tttttttgcg ttgtccttgt caatgccttg 1181101 aacaagcttt gcacgctggc gcaccgttcc gcctgacgcg ttttcaacct tgccgtaatc 1181161 aatgtttttt gtcggtacgt ttcgtttaat caatttgctg accagcacat ctttcagctg 1181221 gcttaatttg aattcgtcat cggaaacgag gaccagctcc tctttatcta aagaaatgtc 1181281 gcttttgctg cctttaaagt catatcgggt actgatttcc ttcagtgcga tttggattgc 1181341 gttttgcact tcaggcaatt ccaccttgga tacaatatca aatgaacttt cttttgccat 1181401 atgaaaacct ccataacatt taacttatgt gttgattata gtagaataaa gagaaacttc 1181461 caacagaaca aagaatcaat ttgtgatgat tggaaaaaat gttaacaaaa tccgcagaga 1181521 ataagcggaa caggaaggac gatagcatga gaccagggca gcaattaacc ttgagtatag 1181581 atcaccaaac cgacttcggt tactttttaa ccgatgggga agatacgatt ctcttacata 1181641 acagtgaaat gactgaggat atcgaggaca gagacgaagt agaagtcttt atatacgtag 1181701 accagcagga aaggcttgcg gccacgatga aaattccgat catcagcgcg gatgaatatg 1181761 gctgggttga agtggtggat aaagtggaag atatgggcgt tttcgttgat gtcggtttat 1181821 cgaaggacgc actagtcgca actgagcatt tgccgccgta cgaagatgtc tggccgcaaa 1181881 aaggggacaa actttactgt atgctgaagg tgacgaaccg ggggcgcatg tttgcgaaac 1181941 cagcgccgga agatatcatc agcgaactgt ttaccgacgc ttcagaagat ctgatgaata 1182001 aagagctgac aggtacggtg tacaggctga tcgcatcggg ttcattcgtg atcacggatg 1182061 acggtatccg ctgttttatt cacccgtcag aaagaaaaga ggagccaaga ctgggttcaa 1182121 gagtcacagg ccgggtgatt caagtgaaag aagacggttc agtcaacttg tcgctgcttc 1182181 cgagaaaaca ggatgcaatg tcagttgatg ctgagtgcat tctaacgtat atgagaatga 1182241 gaaacggtgc catgccgtac agtgacaaaa gccagcctga cgatatcaga gaacgtttta 1182301 atatgagcaa agccgccttt aaacgcgcgc tgggccattt gatgaaaaac ggaaaagtgt 1182361 atcaggaaaa tggatggaca tacgagaaaa aatagcatga aaacggctcg cctgcagcag 1182421 actgcggagc gagccgtttt tttatgtcta gtttaattca tcaaccagcg ttctgattgc 1182481 catttcgcga tccacattgt ctgaaatcgc aatcggcgta atatcaatgg cgagaatgat 1182541 cagaatcagg gcacctgctg cagcaacata agaaacataa tagaaatagt tagcggtatc 1182601 aacagtgttg acaagctcgg cctgaactct ggatgtatca tccttagaag cggcgatttc 1182661 ctttgcagct tctacttttt cttcaacgat ttgacctgct tttttcagca gttcatccac 1182721 tttcaatgca tctttgctgt aaacagcttt cttcaggtta tcaaaaaagt cagcatcctc 1182781 ttttttaata tcagcgacaa cctgattggc aaaagccttt gcctgttttg tgttgagttt 1182841 gtctgtcatc gctttattaa agacctctgg aagctgtttg ccaacttccc cttgggcaaa 1182901 cacaaagcct ttaaaaattt cctcacctga atactcaagc tgctttgcct gtgccacact 1182961 ttcttgctgc ttcaccaaaa acacagtcgt caccaataca accgacaaaa atactagaaa 1183021 cgccttcttc aaactgaaac ctctcccttc ttgtgttttt tattccacaa cagtctgcga 1183081 atatatgtaa attgaatcgt ggaatcgata ggagtgagat acaatatcaa aatgccggcc 1183141 atgataatcg aaaaactgat gaggcccagc atgactgcaa aaatctcatg cataaaaaca 1183201 gcgatgatca aaatcaatct ccaatgcttc ttcggcgcaa acagtgccgc gaagatgaca 1183261 atttgaacca gcagcgtccc ccatgtcgga atcaccacga acggacttgt tacaattggc 1183321 ttcgttaacg cctgaaaaaa gccgttgaag ccaatggttt tttcctgggc gaaataatag 1183381 acggccgttc cgtccaccca ttcctgctga gatagcttag cgacggtaga gtgaaaataa 1183441 agcaccgcca cttggattct gatcacaaaa taagaaataa aagctgttat ttttccaagt 1183501 gttcttttgc cctctatagg tctcgtactc caatgccatt ttctcggatc ggtcagcgtg 1183561 atgggaagca ataaaaaggt catgactgct gctgcctgct cgcctccgtc gatgacgatc 1183621 agcgatgact gcaggctgta actgacatac caatgcagaa ccccggtgat tctggggcgc 1183681 cagccaatga caacaagcac cagaatggca atgcagaccc atctgaaaag atttaacatc 1183741 atatagttat tttcgccgag acaaaagaga ctgagattca ttttacaagc tggatagctg 1183801 ctgatcccgc tggctggctt cataatgagg ctcgggtgat tgatgagcag cgtcagcagg 1183861 ctggatagcg caatgatgct tcgcgcgagg ccatatacat ttgtccacgg gtttctttcg 1183921 tcccatctgg tgatggtctg ttttatgttt tcgagcatga gatcacaacc ttgactatgc 1183981 tttttacctg ataagacgaa ggggtatatt tagaatagct ccaaggaaca atatcctctt 1184041 tcgtcaaata gtagctgcca caaagcagcg ggcggggagc gggtgttttt aattgcacgg 1184101 ttttggcttt gcttttgcat gcgccgaggt ccttttcttt acatgctgtc cactgttcct 1184161 tgccgacttg gctgtagatc acgcccattt caacgccttg tgaccgccca taccgataca 1184221 ggccgaatag gttgtcagcc ctcatattgg gccatctgac cttggcgctg gcattttcag 1184281 cctcatataa gccgattgca gtatcacgcg gatttttgct aaaaaagccc cagccctgag 1184341 ggaggatgct ggacatgaga aatttggagt cctttgtcag cggaatcggg gttgtcccta 1184401 agctgccaat aatagaaaac agaaatagcg aaccccaaag gattgaaaaa atgacaaaaa 1184461 atgatatcga tttctgcatt cgactgctcc ttttaacctg aagaatcgtt tttacacttt 1184521 tcataatata aaaacattta tgtaataaaa aggttaaaaa gtatgagaaa ttccattttt 1184581 gttaaaagga aaaacaggac attttacact gctatatgtg attgatatat agtgtttttt 1184641 tcgatatatt taaaccatga aaacgaatca agttaatgac cgctggattg ttcaatttcg 1184701 aaaagggatt ttcgagctgg ccatcctatc ccttctgcgt tctaaaccga tgtacggtta 1184761 tgagctgacg tcatccttaa aaaccacctc ggcgctggct atttcagagg gagcgattta 1184821 tccgattttg aaacgtatga ccgagaaggg atggatcgaa tttttttggg aagattcact 1184881 ggacggcccg aaaagaaagt attacaaaat gacgcaaaaa ggagaagaaa tgttaaaaga 1184941 acggctggag aaatacctgg aaacccatca agccttactg tctttatcgg gggatttgct 1185001 atgaatggac agcttatcat tgaccgatac atggaggaac taaatgcaga gctggcgaat 1185061 atgcctgatg tagagagaga aaacgctatc gacgaattaa aggggcatat caccgctttc 1185121 gttcaagaca gaatcaaagc cggccttagt gaagaggaac tgcaggaagc tgttgaatct 1185181 gaattttctc atccgaagga gcttgccgaa ttgatgatgg gtgatggggg agagacgaaa 1185241 aggaggaggt ctttattggg caaaagctgg atttcggtcc ttctcattgt cacgattatc 1185301 gccctgccgc tgctgccgtc cgacttcaga catctgccgc tggctgttta tttaatggtg 1185361 ctcgccggat atgtatggaa gcggaaaaaa ttggtgatgt ttgcaggtgt cagaaaaaac 1185421 aaaatgcgct ctcaaaagga gattgtcaag atttcgcgag tcggtgcggt ttatctgctg 1185481 tttttagcag tggtgctcct tttgagcccg ttcctcaatg cgcttgtcgt cctgctgctg 1185541 attgcagtaa gctgcgccgc tttttttctt tttcttaaca tcaagtaatc ttgtaggagg 1185601 ctgtaagatg gaaatcagca tcaattatct attaattgtc atcgcgcttt tattctttgt 1185661 ggttgcctat tttgtcggaa tcaaaaaaca aacctggatg ttggctgggt ttaacgaggc 1185721 gcgtatacgg gataaagatc ggctggccag aatagcaggc tactttttct tgaattccgg 1185781 tttgttcatt ttgctgaata gttttatctc atttcaaggt caggagcagc tcatacctcc 1185841 gcttatactg gcatatggag caggggttat tatttatgtc aataaaaaat tagtagagta 1185901 gaaaaagaag ggcagagcga aatatctctg cccttctttt ttgggaaaat aagaacgaag 1185961 caccacatac aagtttttgt atttttgata ggatgaagaa aaatggtaga ttccaaaata 1186021 ggaaggatgt ggtgttttgc gcaacttgac caagacatct ctattactgg ccggcttatg 1186081 cacagcggcc caaatggttt ttgtaacaca tgcctcagct gaagaaagca tcgaatacga 1186141 ccatacgtat caaacccctt catacatcat cgaaaagtca ccgcagaagc cggtacaaaa 1186201 cacaacccag aaagaatcgc tattttccta tcttgacaag catcaaacgc agtttaagct 1186261 caaagggaat gcgaacagcc attttcgcgt ttcgaaaacc ataaaggatc caaagacaaa 1186321 acaaacgttt tttaaattaa cggaggttta caaaggaatt ccgatttacg gctttgaaca 1186381 agcggtcgcg atgaaggaaa acaaacaagt gaaaagtttc tttggaaagg tgcatccgca 1186441 aatcaaggac gtctccgtca caccgtctat ttctgagaaa aaagcaatac atacagcaag 1186501 gcgtgagctc gaggcttcca ttggaaaaat cgaatatctt gatggggaac caaaaggcga 1186561 attatatatc tatccacacg acggtgaata tgatctcgcc taccttgtga gactctcgac 1186621 atctgaacct gagcctggct attggcatta tttcatcgat gccaaaaacg gaaaggtcat 1186681 cgagtccttt aatgccattc atgaagcggc aggtacagga atcggcgtgt caggtgatga 1186741 aaaaagcttt gacgtcacag aacaaaatgg gcgcttttat ttggctgacg aaacaagggg 1186801 aaaagggatc aatacatttg acgcgaagaa cctgaacgaa accttgttta cgcttttgtc 1186861 tcaactgatc gggtatacgg gcaaagaaat agtcagcggc acgtccgtat ttaatgaacc 1186921 tgcggctgta gacgcacacg caaatgcgca agccgtttac gattattaca gcaagacatt 1186981 tggccgtgat tcttttgatc aaaacggagc aaggattacg tctaccgtgc atgtcggcaa 1187041 acaatggaac aatgctgcgt ggaacggtgt ccagatggta tacggggatg gagacggttc 1187101 gaaatttaag ccgctgtctg gatcgctcga cattgtcgcg catgaaatca cacacgcagt 1187161 cacacagtat tccgccggtc ttttatatca aggagaaccc ggtgcattaa atgagtccat 1187221 ttctgacatt atgggcgcga tggctgaccg tgatgattgg gagatcggcg aagatgtcta 1187281 tactcctggt attgcaggag attcattgcg gtcattggag gacccatcta agcagggaaa 1187341 tccagatcat tactcgaacc gctacacagg aacagaggat tatggcggag tccatatcaa 1187401 ttcgtccatt cacaataaag cagcttatct tcttgcagaa ggaggcgtgc accacggtgt 1187461 acaggttgaa gggattgggc gtgaagcaag tgaacaaatt tactatcggg ctttaacata 1187521 ttatgtaacg gcatctacag atttcagcat gatgaagcaa gcggcgattg aagctgccaa 1187581 tgatttatac ggtgaaggct cgaagcaatc agcttcagtc gaaaaggcgt atgaggctgt 1187641 cggcattcta tgagcaaaca aaaacagtca ggacacagag tctgactgtt tttgtttgct 1187701 cattttctta aaaagaatat cgccaatgta cctggaccgg catgcgagcc gatggctgaa 1187761 ctgattggat gcataatgat ttctttcggc ttgaacgctt cctcaatcag gtgtttcata 1187821 tccgtggctt tttctttgtt cgcggcgtag ctaatcccga cggtttgatt gctccaatca 1187881 tccccgcgct ctttcataag ctcgatgatc cgtttgaaaa gtttcttctg tccgcgaatt 1187941 ttttccagag gcacaagctt gccgtcctcc atctgaagca gcggtttaat attcaacagg 1188001 ccgccgacaa aagcggacgt tttggatatc cggccgcccc tcgcgagata tgttaaatca 1188061 tcaacggtaa aaatgtgttc aagctggctg caaaagttct ttacagacgt ttcaatttct 1188121 tgtattgtat tcccgttgat acagagatcg gcagcatgcc ggacagccag accgtatcct 1188181 aatgaagcgc atttggaatc aatgacccgc aaatcgaaat cggggaattc ctccttcact 1188241 tcattggcga tcattacagc tgtctgatac gtgccggaga gacctgagga aaaggcaatg 1188301 taaagagcgg gatcacctgt ttcggcatat tgcaaaaaca catttttaat cgtttgcggt 1188361 gaggcttggg acgtcttagg cgtttctcca ttttgcatcg cttcaaatat ttgatccgca 1188421 tgaattgtga ctgcatcttc gaattcttta tcgccgagag aaaccctgag cggaataaag 1188481 ccaatgcctt tttcttcaaa ataagaacga ggcaaatcag tggcgctgtc agcgatgaga 1188541 tgaactgtca tattgcttcc cttctttccg ttatcgctcg ttatcatgag agttaagcca 1188601 actatatcat attaatttgc caaaatcgtg ttcaaatatt tgttttaagg gaaaacataa 1188661 taaagaagaa agagcggagg aacatgccat ggtactagat caaacaaaaa aattactcat 1188721 cgtcatcatc ggcgctttac tcaatgctgc cgggctgaac ttatttttga tacctgcaga 1188781 tgtatatgcc agcggattta caggtgttgc ccagctttta tcaagcgtcg ttgatcaata 1188841 tgcccccttt tacatatcga cgggaacgct cttgttcctc ttaaacattc cggtcggtat 1188901 tttaggatgg ctgaaggtcg gcaaatcgtt tacagtgtac agcattttaa gtgtcgcact 1188961 cactactctg tttatgggga tcctgccgga aacaagcctg tcacatgaca ttttgctgaa 1189021 cgcggtgttc ggcggcgtca tttccgcagt cggtatcggc ttaacattaa aatacggagc 1189081 ttcgacaggc gggcttgata tcgtcgccat ggtacttgca aagtggaagg ataaacccgt 1189141 cggcacgtat ttcttcattc tgaacgggat tatcatcttg acggcaggat tattgcaagg 1189201 ttgggagaaa gcattatata ccctggttac actatatgtg acaacgaggg tgatcgacgc 1189261 cattcacact cgccacatga agcttacggc aatgattgtg acgaaaaaag cggacgaaat 1189321 caaggaagcc atttacggaa aaatggtgcg cggcatcaca actgttccgg caaaaggagc 1189381 atttacgaac gaacagaaag aaatgatgat tatcgtcatc acgaggtatg aactgtacga 1189441 tttagaaaag atcgtcaaag aagttgatcc aaaagcattt acgaacatcg ttcaaacgac 1189501 agggattttt ggtttcttta gaaaagactg acgaaagcag gtggaagtcg tgaaacggct 1189561 gcttgtgatg ctcctccccg tgctgctttt gataggctgc gggaaagatg agcagacaga 1189621 acccgataag gaggtatcag gcggaatgga gaatcaagag gttgttttat ctattgacgc 1189681 aattcaggag cctgaacaaa tcaagtttaa catgtcgctg aagaaccaaa gcgaacgtgc 1189741 tattgagttt caattcagca cagggcaaaa atttgaactt gtcgtgtatg attctgagca 1189801 caaagaaaga taccgttatt cgaaagaaaa aatgtttacg caggcttttc aaaacctgac 1189861 gcttgaatct ggagaaacat atgatttctc tgatgtgtgg aaggaagtcc ctgagcccgg 1189921 aacctatgag gtaaaggtga catttaaggg cagggcggaa aatctcaagc aggttcaggc 1189981 tgttcagcag tttgaagtca aataagaggc tatggcgagt cgccatagcc tttttttatt 1190041 gcagtttgtc cagctgattt tgaaattgat gcaactgttg acgttccgca tctgtcgaat 1190101 tggcatacgc agaagataca gcatttttgg ctctcagaat cgcttgctcc tgatcgcctt 1190161 cctcaaagcc gtttgtcacc atgaccgcct gttgaacaaa tgattttgcc tgctgaaaca 1190221 gttcatttct catttaatat tcatactgcc tttcagccga gtctcgtgcc gcggcatgct 1190281 ggtgagcttc ttctaaagta gaccgatatg gaaatcttgc ggcgtgtagc ccgatggagt 1190341 ctttaccctg ctgaataaac cttctggatt tgcttcgttt acccattttg agactgcccc 1190401 cttccatact ttgacgagat gagtcgtctt caatagtatg gtggggtaaa gtaaggttta 1190461 tgagtgggaa aaattaatac ggaccttctt taaagtgaga aatattcttt caaaaacctt 1190521 gccacgccgt cctcttcatt tgtggccgta gttcggttgg caatctgctt gaccgcgtca 1190581 attccatttc ccattgcaac gccgcagcct gcaaattcaa gcatttccaa atcgttatcc 1190641 tcatctccaa aagcaatgat ccgctccctc ggcacgccgt aataatcgct gattttctgc 1190701 aggccgaccg ctttattcat gccgcttttg ataatttcaa tgacatgcca aggagcggcc 1190761 catcttctat ggtcgatcac ctcggcatgc acatccgata aatatgagcg tattgccggc 1190821 acatcctctt cctttgcatg tatgagtacg gacgtcacat cttcaccgag attttcccgc 1190881 aagtctccga ccgttacatt tgttgtgttc atgttaaagg catctatcag gtgctcatca 1190941 tggtaatgaa agtatacgtc gtcaatcact tcagcaagca cgttatgtac gttgtagctc 1191001 tcgctgatat ccacgagctg tttgacaaca tcaagcggca gtgacgtatg ataccgtccc 1191061 cagctgtcgt cttgcggatg atggacaaat gctccgttaa aattgacaat tggcgttgtc 1191121 agctccatct gctggtagta catggaactt gaacgatacg gacggcctgt tgagatgcag 1191181 acataatgcc cgtcatcttt taggcgctgt atcgtatgaa gggtgttttc agatatggtt 1191241 ttatcatcct ttaataatgt tccatctaaa tctaatgcga ttaaataggg ttttgtctcc 1191301 atgaaaagct cctttaacct tagattttgc ttgttttgcc ttacttacag tgtagctttt 1191361 taccatcttt attgtctaca tgttacactt atgattatgg ttatcctaag gaggggcaca 1191421 ttgtgataca aattgagaat caaaccgttt ccggtattcc gtttttacat attgtaaagg 1191481 aagagaacag gcaccgcgct gttcctctcg tgatctttat acatggtttt acaagcgcga 1191541 aggaacacaa ccttcatatt gcttatctgc ttgcggagaa gggttttaga gccgttctgc 1191601 cggaggcttt gcaccatggg gaacggggag aagaaatggc tgttgaagag ctggcggggc 1191661 atttttggga tatcgtcctc aacgagattg aagagatcgg cgtacttaaa aaccattttg 1191721 aaaaagaggg cctgatagac ggcggccgca tcggtctcgc aggcacgtca atgggcggca 1191781 tcacaacgct tggcgctttg actgcatatg attggataaa agccggcgtc agcctgatgg 1191841 gaagcccgaa ttacgtggag ctgtttcagc agcagattga ccatattcaa tctcagggca 1191901 ttgaaatcga tgtgccggaa gagaaggtac agcagctgat gaaacgtctc gagttgcggg 1191961 atctcagcct tcagccggag aaactgcaac agcgcccgct tttattttgg cacggcgcaa 1192021 aagataaagt tgtgccttac gcgccgaccc ggaaatttta tgacacgatt aaatcccatt 1192081 acagcgagca gccggaacgc ctgcaattta tcggagatga aaacgctgac cataaagtcc 1192141 cgcgggcagc tgtgttaaaa acgattgaat ggtttgaaac gtacttataa agcactaagt 1192201 tattaacaag agctgaattt acgttatact gtagaaaaaa ggagtgaggg aacgtggaag 1192261 aagcattaaa agaaaacatc atgggcgccc tggaacaggt tgtcgatcct gagcttggcg 1192321 ttgatatcgt gaacctcggc ttggtatatg acgttgatat ggatgaagat ggcttgacgc 1192381 acatcaccat gacgctaaca tcaatgggat gccctttagc gccgattatc gtggatgagg 1192441 tgaaaaaagc attagcggac cttcctgaag tgaaagacac agaggttcac attgtatgga 1192501 atccgccttg gactagggat aaaatgtcca gatacgcaaa aattgcgctt ggcattcaat 1192561 aaaacaaaaa aggacagcct gacatgtgag gctgtccttt tttacagctg aaaggagtga 1192621 aaggaaatga tgtacctgct ggcagtttta tgcccgccgc ttgctgtttt gttttcggga 1192681 aaaccgtttc aggccttgct gaatctcata ttgacctgta tcttttggct gccgggcgcg 1192741 attcacgcct gctttatcgt cgccgaccgc cgtgccgaaa aacgggcaag aagataattt 1192801 ggaaaaatga ggacgcagtc atggtataat ggtcataaaa acagcaggga gagcactatg 1192861 aaaaagaaat tgcttgcatt cgcgctttgt actggcgcgt atgcggccct gtttgcgtac 1192921 tctgtgaact cagagcaaaa aacagccaca agcgagatga cggatgtcag ccgcctgatg 1192981 cctgtaaaaa taaagcagac agtgaaaggg caggaagagg aaatgctcat tgacacagtc 1193041 aaagaggcaa atcgaaaaaa cataaaaatt tcaatcgccg gggcccagca ctccatgggc 1193101 ggccatacat attatgagga cggcatcgtt ctcgacatga cgggctacaa caaaatcctg 1193161 tcactcgatc aagagaagaa aaccatcagg gtgcaaagcg gtgcaacgtg gaatgatatc 1193221 cagaaatacg tgaatccata cggactcgcg gtaaaagtca tgcagtcaca aaacattttt 1193281 acaatcggcg gatctctcag cgcaaatgca cacggacgtg atattcgcta cggctcgcta 1193341 attgatacag tcaaatcatt ccggctttta aaagctgacg ggatgattat cactgtcact 1193401 ccaaaagatg atttgtttac ggcggtcatc ggagggtacg gcctttttgg cgtgattctt 1193461 gatgtaacgc ttgagctgac agatgatgag ctgtatgtca tgaagacaga aaaaatgaat 1193521 tacagcacat actcagacta tttttcaaag catgtaaaag gaaatccaga tgtccgaatg 1193581 catctggcgc gaatttcaac agcgaaaaaa ggatttctga aagacatgta tgtcacgaat 1193641 tacgtattgg ctaatcatca ggatcagctg tcctcataca gcgaacttaa agaagacgag 1193701 tatacgggag ccacaaagtt tgcactcggc ttgtcaagac ggtatgaatg ggggaggaat 1193761 tggctgtggg acacacagca atcctatttc ctgagccaga acggcacaga gatttcacgc 1193821 aataacgtca tgcggtccga atcaaagttt cttgagtatg aaaacaatga caacacagat 1193881 gttttgcaag aatactttgt gcccgtgaag gagtatgggt cctatattga tgacctgaga 1193941 caaacgctgt cggacgaaga tctgaacctg ctgaacatta cgatccgcta cgtgcagaaa 1194001 aatgaaaagg ccgacctttc ctatgcgaag gacgatatgt tttcgctcgt actattaata 1194061 aacgagggct tttcaaaaga agaccaggca gataccgccc gaatcatcag gcgcatgaca 1194121 gacgttgcca tcaagcacgg cggcagctat tatctgcctt atatgaccta ccagacaaaa 1194181 gcgcaaatga gacaggcata tccgaaaagt gaagcgtttt ttcagaaaaa acgaacctat 1194241 gacccggatg agcgctttat gaattacttt tatcagaggt ataaataatg gggaaaaaca 1194301 aattaaaatg gctgacatta tcacaaagca gcgtgttttt cgcaagcagc ttaatctttc 1194361 cgttttatat tctgtttgtg aaaaatatcg gctcaagcta cacacagttc ggtttttcct 1194421 acggattgtt cgggttgagc ggagcgctta tttacccgct cctcggacgg ctgtctgaaa 1194481 ggtttgacag ccgttatttt ctgcttctga actcgtgggg gatggctgtt ctgcttttat 1194541 atgtcccgca tatcggaagc gtcgttcaag tgtatatcgt ccaagtgctg ttagggctct 1194601 ttggagcgat gcaaaagcat ggagaaaaag tgctgatcgc taattttaca gacagtggag 1194661 agcgtggaaa gaagatcggg aattaccatt tttggacagc tgtcttttca gcagcagcca 1194721 ttatgctcgg gggctttctc gctgactttt tcacagtgca aatgattttt tatgcaagct 1194781 ctattctata ttttttgagt ggattgatga tgatgaaaac aggctgacgc ggtcagcctg 1194841 tttttttatg cggctgaaat gcggcaccgc atcaacgttt ttgtgctgga gtcgtgctga 1194901 ttttttttga gcggaattcc cattgaacag aaaatttata aatgaataaa aatattaaat 1194961 atacgattga attaattttt attcatgtta taatgttaaa taatttcaca aagaccaaga 1195021 gggtgaactt gttttgaaaa taggaattgt aggtgctaca ggatatggag gcaccgaact 1195081 tgtcaggatt ctttcgcatc atcctcatgc agaggaatgc atactttatt catccagcgg 1195141 agaagggaat gtctatagcg agggttatcc tcatcttacc ggcttagcgg atcagcagct 1195201 gaagccgatt gatatgaata cgatcaaaca cgaaatagat atcatgtttc tcgctgcgcc 1195261 gcccggagta tcaagtgaat tgactccaaa gctggcagac gcgggaatta cggttattga 1195321 tctgtcaggt gatctgagga taaaagaacc ggctgaatat gaaaaatggt ataaacggac 1195381 agcggcaccg aaggcggtga ttcaagaggc ggtatacggt ctggcagaac tgaatcaact 1195441 gcaaattcaa caggcgaaac tcattgccaa tccaggctgt tttccaacag ctgttttgct 1195501 tggcctcgcg ccattggctc aaaagaaact gctcgatgaa tctttcgtta tcgttgacgc 1195561 gaagaccggt gtttccggag cgggaagaaa agcatccatg ggaactcatt tttctgagct 1195621 gaacgacaat tttaaaattt ataaagtcaa tgaacatcag cacacgccgg aaattgagca 1195681 ggcgctgaat gaatggcagc caggtctcgg gcccattaca ttttcggctc acttggttcc 1195741 gatgacaagg ggcatcatgg cgacgatgta taccagatta acctgtgacc taaccgcaga 1195801 tgacctgcat gatttatatt cggaatttta ccaagattca tattttgtga gagtgaggcc 1195861 aaaaggtcag tacccgcaaa cgaaagaagt gtacggcagc aatttctgtg atatcgccgt 1195921 gaccctcgat gagagaacga acagagtcac gatcgtctcg gtaatcgata atttaatgaa 1195981 gggtgccgcc ggtcaggcag tgcaaaactt taatttgatg aatggctgga atgaagaaac 1196041 tggactcacc atcacgccaa tttatccata gaacgggaga gaatcgaacc atgattcagt 1196101 taagtgaaga tcaaattgta aaagtaacag gtgatgtatc ctcgccaaaa gggtttcagg 1196161 caaagggtgt gcattgcgga ctgcgctact cgaaaaaaga cctcggcgtc attatcagcg 1196221 agacaccggc cgtgagtgca gcagtttata cccaaagcca ctttcaggct gctccgatca 1196281 aagtgacaca agacagctta aagcacggac cgacactgaa agccgtcatc gtcaacagcg 1196341 ccattgccaa cgcctgcacg ggagaacagg gcttaaagga cgcatacaca atgcgggaga 1196401 gctttgcttc acagcttggc attgagccgg agcttgtcgc tgtttcatca acgggtgtca 1196461 tcggcgagca tttagacatg gaaaaaatcc acgcggggat cgaactgctg aaagaaacac 1196521 ctgcgggatc aggcgatttt gaggaagcga ttttaacaac tgatacggtg atcaagcaga 1196581 cgtgctatga actggcaatc ggcggcaaaa cagtcacgat cggcggagcg gccaaaggct 1196641 ctgggatgat acacccgaac atggccacga tgctgggatt tgtgacaact gacgcggcaa 1196701 tcgaagaaaa agcgctgcaa aaggcgcttc gggaaatcac tgacgtttca tttaaccaaa 1196761 tcacagttga cggagaaaca tccacgaacg acatggtatt agttatggcg aatggctgcg 1196821 ccgaaaacga gtgcctgaca gaagaccatc cagactggcc ggtctttaaa aaagcgctct 1196881 tgctcacttg tgaggatcta gctaaagaga ttgccagaga cggagaaggc gcgacaaaac 1196941 taattgaagc ccaagtacag ggagcgaaaa acaatcttga tgcaaacgtc attgccaaaa 1197001 agattgtcgg ctcaaatctt gtaaaaacgg cagtatacgg aacagatgcc aactgggggc 1197061 ggatcatcgg agccatcgga cactccgcag cacaggtgac ggcagaagaa gtagaggttt 1197121 atcttggcgg ccaatgcctg tttaagaata acgaacctca gccattctct gaatctatcg 1197181 ccaaggaata ccttgaagga gatgaaatca ccattgtcat caagatggct gaaggggacg 1197241 gaaacgggag agcgtggggc tgtgacctga cctatgacta tatcaaaatt aacgcgagct 1197301 atcgcacgta ataaagggga gcgaaatgaa gaaaacaatc gtttttaaat gcgggggaag 1197361 cgtcatccgt gagctgtcgg aggaatttta tcaaaatctg aaagagctga gggcgtcagg 1197421 ctggaagctg gcaatcgtac atggcggggg accggaaatc acaaatatgc tgaaacggtt 1197481 aaatatcaag acagagtttt cgggcggaca gaggaaaaca acgaagccgg tgctggaagt 1197541 ggcggaaatg gttttatccg gttctgtcaa taaatttttc gttgctgagc ttgccaaaca 1197601 cggactgcga gccgcgggca tttctggtaa ggatggcggt cttttggagg ctgattatct 1197661 agatccggaa acatacggag aagtgggaga aatcaaaaaa gtcgatgcgt ccatggtgaa 1197721 cgcgctgatg gaaaatggca tcatccccgt tattgcgccg ctgtctatga caagcgactg 1197781 caaaacgctg aatgtaaatg ctgatctggc tgcttcagca gtcgccggag cgcttgaagc 1197841 cgataagctg atgttcgtca cggatgtcga tggaatcatg aaggaaaagc agcgtctgga 1197901 cgtcctgacc cctaaggaga ttcagatgct gatcaagcag gaagtgatca caggagggat 1197961 gatcccgaag gtcaattcag ccttgtcagc tttatcagat caggtgtctg aagtcatgat 1198021 cgtaaacggt aaaggatcat tcttcgcaga acaaaccttt caagggacaa aaattgtcaa 1198081 agcaaaggag gctgtttcat gagcagcttg tttcaaacct acggccgttg ggatattgac 1198141 atcaaaaaag caaagggaac gtacgttgag gatcaaaacg gcaaaacgta ccttgatttc 1198201 attcagggga ttgcggtatc aaatctagga cactgccatg aagcggtgac agaggcagtc 1198261 aaaaaacagc ttgacagcgt atggcacgta tccaacctgt ttcaaaacag tctccaagag 1198321 caagcggcgc agaagctggc agcgcatagt gcgggagatc ttgtcttttt ctgcaacagc 1198381 ggcgcggagg cgaatgaagg tgcgataaag cttgccagaa aagcaactgg aaaaacaaaa 1198441 atcatcactt ttcttcagtc gttccatggc cgcacgtatg cagggatggc tgcgaccgga 1198501 caggataaaa tcaaaacagg cttcggcccg atgcttggag gctttcacta cctgccatac 1198561 aatgatcctt ctgcttttaa agctcttggg gaggaaggcg atattgccgc ggtgatgctt 1198621 gaaacagtgc agggagaagg aggagtcaat ccggcgagtg ctgaattttt atcagccgta 1198681 cagtcgtttt gcaaggaaaa gcaagccctt ctcattattg atgaaatcca gaccggcatc 1198741 ggacggacgg gaaaaggctt cgcatatgag cacttcggac tctcaccgga tatcatcaca 1198801 gtcgccaaag gattgggaaa cggctttccg gtcggcgctg tcatcggaaa gaaacagctt 1198861 ggagaagcgt ttacccctgg ttctcacgga acgactttcg gaggaaacat gctggcgatg 1198921 gctgctgtga atgccacatt gcaaattgta ttccagcctg actttttgca agaggctgct 1198981 gacaaagggg cgtttttaaa agaacagctt gaggcagagc taaagagccc ttttgttaaa 1199041 caaatccgag gtaaaggatt aatgcttgga attgagtgtg atggcccggt tgctgacatt 1199101 attgctgaat tgcagacatt aggcttgctt gtattgccgg ccggcccgaa cgtgattcgg 1199161 ctgctgccgc cgctcaccgt gactaaggat gaaatagcag aagccgtcag caagctgaaa 1199221 caggcaatcg ctcatcattc cgctgtaaac cagtgatttt ttttcgatat aaaggcataa 1199281 aaattcattt ttataattaa ttattcatca agaggtgggc tgttagatgg aaggttattt 1199341 agtgttagaa gatgggacat cgttcagcgg cgagctggac ggtcatgaaa actgcacggg 1199401 agaagctgtt tttttcacag gaatgacagg ctaccaggaa gtgctgacag atccatcata 1199461 taagggacag attattgtat ttacctaccc gctgattggc aactacggca taaatgaaaa 1199521 ggattttgaa agcaagaaac cgcaagtaaa agccgcggtt gtctatgagg cgtgtgatca 1199581 cttttctcat tatgaagcgg tatacagcct caaggagtat ctacagaaat ggaatattcc 1199641 gctgttaacc catgttgata cgagggctgt cgtgaagaaa atccgggcaa acgggacgat 1199701 gggtgcgaca gtcacagcct ctaaagaagg agctgagatt gcccttcaac cagagaatgt 1199761 ggcagagcag gcttccgccc aggaaatcag cacattcggc gacgggaata aacatatcgc 1199821 tctcattgat tttggctata aaaagtcaat cgcatcatca cttgtcaaac gaggctgcaa 1199881 ggttaccgtg gtgccatacc agcaaatgga ggccgtatac aacatcaaac ccgatggaat 1199941 tgtgctatcg aacggacctg gagatccgaa agccattcag ccatatttag gaaagatcaa 1200001 aagcatcatc agccgctttc cgactctagg catttgtctc ggacatcagc tgatcgcgct 1200061 cgcgtttgga gggaatactt ttaagctgcc attcgggcac aggggagcta atcatccggt 1200121 catcgaccgt aagacgaaac gggtctttat gacaagccaa aaccacagct atgtggttga 1200181 tgaacagtcg attaatgaag aagagctcac catcaggttt catcatgtca atgatacgtc 1200241 agttgaaggg cttgcccata aaaaactgcc tgtcatgagt gttcaattcc acccggaagc 1200301 ccatcccgga cctgcggaaa gcgaatggat ttttgatgat tatctaaaga atgtgatacc 1200361 agcaaggaga gaaatcgcgc atgcctaaag acaccagtat ttcaagcata ttagtaattg 1200421 gctcaggccc gatcatcatc gggcaggcgg cagaatttga ttattcaggc actcaagggt 1200481 gcatcgcgct gaaggaggag ggctaccggg taattctcgt caacagcaat ccggcgacaa 1200541 ttatgactga tgaagccttc gctgatgaaa tttattttga gcctctgaca gcagaaagcc 1200601 tgacagccat cattaagaaa gaacggcctg atgggcttct tgccaattta ggcggtcaga 1200661 ccgcgttgaa tttagcggtg gagcttgaag aaacgggtgt tttaaaagag cacggcgtca 1200721 aactcctcgg cacatccgtt gaaacgatac aaaaaggaga ggaccgggaa aaattccgtt 1200781 cgttaatgaa tgaattaaaa cagcctgtgc cggagagtga aattgttgat aacgaggccg 1200841 atgccctcca ttttgcggaa tccatcggtt ttcctgttat tatcagacca gcttacacat 1200901 taggcggaaa gggcggagga atcgcccctg ataaagaagc ctttacagct atgattaagc 1200961 aggcgctatt agcaagcccg atcaatcaat gccttgtcga aaaaagcatt gccggcttta 1201021 aagaaattga atatgaagtc atgcgtgaca gcaataacac atgcattacc gtctgcaata 1201081 tggaaaatat cgatccggtc ggcgtgcata caggtgactc tatcgttgtg gcgccgtcac 1201141 aaacattgac agacgaagac tatcaaatgc tgcggacagc aagtctgacg atcatctcag 1201201 cacttgatgt tgtaggcggc tgcaacattc aattcgcgct tgatccattc agcaagcaat 1201261 attacgtcat tgaagtgaat ccgcgtgtaa gccggtcatc ggctctcgca tctaaagcga 1201321 ccggttatcc gattgcgaag atggccgcga aactggcagt cggatacact cttgacgagc 1201381 tgaaaaatcc gctcacaggc tcgacttacg caagctttga accggcactg gattatgtga 1201441 tcgtcaaatt tccgcgctgg ccgtttgata aattcaaaaa cgcagaccgc aagcttggca 1201501 caaaaatgaa agccaccggt gaagtgatgg cgattgaacg gaatttagaa gcggcgatac 1201561 aaaaggcagc cgcgtcgctt gaattaaaaa atatcgggac acaccttcca gagctcagcg 1201621 ggttgtcaat tgatacgcta tgggatttgg caatcactcc ggatgaccgc agatttttcg 1201681 ttgtcatgga gctgttgagc cgcagcgtct cgattgatga catccatgaa aaaacaaaaa 1201741 ttgatccgtt tttccttcat acctttgaca acatcatcaa attggaaaac cgcctgatgg 1201801 aagcagggag cgatctctct tttgaattat tgaagaaagc aaaggaaaag ggattctcag 1201861 acgcaacgat tgcctcgctg atcagcaaaa cagaagaaga ggtgcgcgcg cttcgcaagg 1201921 agatgggcat tacgccttcc tttaaaatcg tagatacatg cgcggcagag tttgatgcga 1201981 aaacaaacta tttttactcc acatatttcg gagagaccga tggagacatc agccgcaaag 1202041 agaaaaaacg cgcgctcatt atcggatcag gcccgattcg gatcggccaa ggcgttgaat 1202101 ttgattacag tgctgttcac ggtgtgctga cactgcaaga gcttgggttc gaaaccatca 1202161 tgattaacaa taacccggaa actgtcagca ccgattatga aattgcggac cgcctgtatt 1202221 ttgaaccgat gacaacggag catattgtaa acgtggcgga gcaggaaaat attgattttg 1202281 caattgtgca atttggcggt caaactgcaa tcaatgctgc tgaagcgctc gaaaaagccg 1202341 gcattactct tcttggcaca tcatttcaaa cgctcgacgt gttagaggat cgggatcaat 1202401 tttatcagct tcttgacgag ctgggattga agcacgcaaa aggagaaatt gcttatacaa 1202461 aagaagaagc cgcttcaaaa gcgagtgaga tcggctatcc ggtgttaatc cgcccatctt 1202521 acgttatcgg cggaatgggc atgatcattg ttgactcgca agcccagctt tctcagctgc 1202581 tgaatgatga ggacagcatg ccatacccga ttttaattga tcagtatgtg tctggaaagg 1202641 aagtcgaaat tgatttgatt tccgacggcg aggaagtctt tatcccgaca tataccgagc 1202701 atattgaacg ggcaggtgtc cattcagggg acagttttgc cattcttccc ggaccgtcca 1202761 tcacgagcgg gctgcagcag ggcatgaaag atgcggcaca aaaaattgcc cgaaaacttt 1202821 catttaaagg catcatgaac attcaatttg tgatcgacaa tggaaacata ctcgttcttg 1202881 aagtgaatcc gagagcgagc cgcacggttc ctgtcgtcag caaagtaatg ggcgttccga 1202941 tgattccgct cgccacacgt ctgctggcgg gagcgtcctt aaaagatcta aatccggcag 1203001 ttcaaaatca tcatggagtt gccgtgaagt tccctgtttt ttcttctcat gcgatccagg 1203061 atgtggatgt caagcttgga ccggaaatga aatcaacggg agaaggcatg tgtgtcgcat 1203121 atgattctaa cagcgccttg aaaaaaatct atacaagagt ctggagtcaa aaaggaagca 1203181 tttatttgca aaacgttccg gaagatgtga aggagttagc agaaaacgca ggttttacaa 1203241 tacatgaagg aacatttgcc tcatggatgg aacaggaagg aaactcgctc cacattaatc 1203301 tgagcggttc tgaagaagca cgcaaagaac gtttggaagc catgacgcac ggcatccccg 1203361 tctttacaga agaagaaact gtgcgggcgt ttttacaaag cggttcaggc catccgcagc 1203421 ctgtatctct caaagacctc tataaaaagg aagtggcatc atgcacacag tgacgcaaac 1203481 cagtttatac ggaaaagatt tattaacgtt aaaggacctt agtgaagaag atataaacgc 1203541 cttgctcgca gaagccggtg agctgaaaca aaacaaaatt cagcctatat tccatggcaa 1203601 aaccttggcg atgatttttg aaaaatcatc aacgcggacc cgtgtttcat ttgaagcggg 1203661 catggcgcag ctgggcggga gcgccctctt tctaagccag aaagatctgc agctggggcg 1203721 cggtgagact gtcgctgata cggcaaaagt gctgtcaggc tatgtggatg ccatcatgat 1203781 ccggaccttt gaacatgaaa aggtggagga acttgccaaa gaagctgaca ttccggtgat 1203841 caatggactt accgataaat accacccatg ccaggcgctg gcggatctct tgacgattaa 1203901 ggagataaaa gggaagctta aaggcgtaaa agtcgcgtac atcggtgacg gaaataacgt 1203961 ggcgcactcc ttgatgatcg gctgcgcgaa aatgggctgt gatatctcga tcgcttcacc 1204021 aaagggatat gaagtgttag atgaagcagc tgaagcggca aagacatatg cacttcaatc 1204081 cggctcttct gtcacgctga cagatgatcc gattgaagct gtaaaagacg cggacgtgat 1204141 ttattctgat gtgtttacaa gcatggggca ggaagcggaa gagcaagaac gtcttgctgt 1204201 ctttgcgcct tatcaggtga atgcggcgct ggtcagccat gccaagcctg actatacatt 1204261 tttacattgt ctccctgcgc atcgcgagga agaagtgact gcggagatta ttgacgggcc 1204321 gaactctgca gtgttccagc aggcggaaaa ccgtcttcat gtgcaaaaag cactgctgaa 1204381 ggccatttta tataaagggg aatcatcaaa aaactgctga gccaaactca gcagtttttt 1204441 tgatggcaac atattcacag ccgcttaggc gcatactaca gcaaaaagga aaaggaggaa 1204501 aaacagtggg acagcagcac caattccggc ccggacagaa agcgcctaat aacggtgtct 1204561 acgtagaaat cggcgagaca gggagcatgg ttaaaaaccc tcaaaaggtc catctgtcag 1204621 caggggaaat gttccccgaa acatcaaacc acaaccggct gtggacctac aaaagaaagc 1204681 cgtgaccact aaaaaaccca aaacaataaa tgttttgggt ttttggcttt ttaatgctgg 1204741 cttgcatttt tgttcatagg catgatttct gctaaaacca tgattaagac atacagtaca 1204801 acagcaatga cagatgatgt tttgaaatta tacgtaacgc tgttcatgct tgcaaccaag 1204861 tagcatgcca tatgtgataa aaggaacgtc caaataaagg caataatata tcgcacgttt 1204921 ccacctcgtc cttctcattc tattctaaaa gttatcatac catacaaaaa gcgaaggggg 1204981 aatccaattt tagcagaaag tgaggtgaca aaagagtctg attcgtcaca ctttaatggt 1205041 aaaatataaa acgtcaatca gtataatagc caaaaatgta aaaggctagg actttacctt 1205101 attcgtttct tttctattta cataagatag cgtgagatga agtgtgaaag gaggcgggca 1205161 agcgatggga ataacggaaa gatactttca actgggaacg gagcataatg tcattcatct 1205221 gccctatcgc ccgaacggct tcggcatctt tatcttgggg gacagaaccc actttgtcgg 1205281 acatgattca agcttttggc agcagcatta tggcagaaat cagcttctga gcatgttgat 1205341 gaatgaagga tacactcttt ttaacagcaa tctgttcgga aggcattggg gggcggaaaa 1205401 agcagtcacc tatgccaaac agctgataca ttctgtgctg aagcaggaaa tcctcaatcc 1205461 gaagattcat attttagcag aaggcatggg tgctctcgtg gccgatgaac tgcttcgttt 1205521 ttccccggat catatccgct cagccgcaat gttgaatcct tgtctcgatc ttcaggcaca 1205581 ttatgaatcg gaaaaagaaa ataaattttt ctataagcaa tttttgaaag aagtatcgaa 1205641 aagctacgga atttctgaaa aagaagcgga agcgattcgt tataaaacaa ttcaaagcta 1205701 cccgagcggc gtaccggttc atatatggca gcgtatgacc ggagctccat atccctacag 1205761 cgtacatgcg gaagttttca aggaaaaaca gcaaaagcaa ggctcaccgg tcgacatgac 1205821 atttcattta tttgagcatc caagcagaat ttatgcatca atttgcaaat tctttcatag 1205881 tcatgaaaaa gaattataga gaatataatg acaacagcct tctcttttgc ggaggctgtt 1205941 ttgttttggg aaatgaaaaa ccggaagggc ggcagatgca atggaatcaa cgctgattgt 1206001 aggtgcggac gaatttttcg gcctttcatt atgtgagcga atgatggatg aaggcataca 1206061 tgttgacgtt gttctggcgg aaacagaaga taaaatgaga caaatgtact tagaagaaag 1206121 actcatgtgg cttgggagaa atgaactctt tcgccagctt gaacacattg gagaccaaaa 1206181 ttatgataca atttgtatcc agttcggaag ttttttgcct ttagaccaat atgattctcc 1206241 ttatatttta gtatatgaag aagaccgaaa agaatgggat aaacgtgaaa aaacaggctc 1206301 ggaaaaaacc gtgatcctgc cgaaaatgta cgggccatgg aaagaagaaa cagaggaaga 1206361 cggctattac acaaacgacg tggctgacga gttgctgaga ttcctgttag aaccaagccg 1206421 tcatagcaaa gatcagcttt ttgaattgca agtcacagag aaaacctcaa aagaagaagc 1206481 aaaaacaaaa attatcgagt ggaaaagaca attttcatca attttcgaca aatattaaga 1206541 aaaaccttcc atgtttcgag ttttctagat acaataaacg tataaaaata atacatgtta 1206601 tagcttgtca aaaggagttg aacatgactt gatcacaagg cttgtcatga tcttttctgt 1206661 cctcctttta ttgagtggat gtggacaaac tccgttcaaa ggaaaaattg agaaggtcgg 1206721 catgctcttt cctgatacga ttaatgacct cgtatggggc acaaaagggt ataaaggatt 1206781 actgaatata caatccaaat acaatgtgga cgtctattat aaagaaggcg ttaaaacaga 1206841 agaagatatc ataaatgcga ttgaggattt tcataagagg ggcgtcaatc tgctctacgg 1206901 ccatgggagt gaatatgctg aggtgtttaa cttggtcggc gaagattatc cagatatgga 1206961 attcgtcatt tccaatgcga aagcgaaagc tgataatgta acaagtgtcc attttagcgg 1207021 ggaagcaatg ggcttttttg gaggaatgac tgctgcccat atgtcgaaaa cgaatcaggt 1207081 cggtgtaatt gcttccttta cgtggcagcc tgaggttgac ggttttatca aaggggccaa 1207141 gtatgaaaat ccggatatag aggtaaatac gaaatatacg gatcattggg atgatgatac 1207201 aacagcagta aagctttatc agaaaatgaa gaacgaaggc gcggatgttg tgtatcccgc 1207261 cggagacggg tataatgttc ctgttattca gcaaatcaaa aaagacggtc tttatgccat 1207321 aggctacgtc acagatcaat cggatctggg cgagaatacc gtattaacca gcacggtgca 1207381 aaatgtggac aaggcctatg aaatcattgc tgaacaattt aataaaggca cccttgaggg 1207441 cggcgatcat tactacgacc tgaacacggg agtcgttgag atgggaacat tcagcccgct 1207501 cgtcgatcaa gactttcagc aaagaatcgc caagctgatc aaaacataca acaaaacagg 1207561 cgagctgcca aaaaacgagt aatggagtga cgtcacatgc agcacgaaaa atcacttgaa 1207621 ttcttgcaaa ttgccatgaa atatctccct gaagcgaaag aacagcttga gaaatcaggc 1207681 attgagctct caatggaggc catccagccg tttatgaatc tatttacaac ggtaatggcg 1207741 gaagcttatg agcttggcaa gtctgacgct aaatctgaaa cagaataaga agaagccact 1207801 tttttgaaag tggcttttca catgattttc tttttaatag cggagagcat gggcgcaagc 1207861 tcctttaaag cgggcttgat ttgatcaaga gagttcataa ttgaaccgat ttggtccata 1207921 atatgcatgt aattaatcgt ctcttcgtcg tttgtctgag aaacctgaga aacttcctct 1207981 tgctgttcct cctccttctc ttctgttggt tttgctgcat cgccgaacat cattcttgaa 1208041 aacacatcca actgcatacg cctcctttcc atataccata ctctatgagt aagatgaact 1208101 gatagtttag acgaatatat tgccatgtga aaaaaaatag gatagaatta gtacctgata 1208161 ctaataattg atcacaacct gattgatctt ctaaatttaa gatataaagg agtcttccct 1208221 aatgaaagct ggaatacttg gtgttggacg ttacattcct gagaaggttt taacaaatca 1208281 tgatcttgaa aaaatggttg aaacttctga cgagtggatt cgtacaagaa caggaataga 1208341 agaaagaaga atcgcagcag atgatgtgtt ttcatcacat atggctgttg cagcagcgaa 1208401 aaatgcgctg gaacaagctg aagtggctgc tgaggatctg gatatgatct tggttgcaac 1208461 tgttacacct gatcagtcat tccctacggt ctcttgtatg attcaagaac aactcggcgc 1208521 gaagaaagcg tgtgctatgg atatcagcgc ggcttgtgcg ggcttcatgt acggggttgt 1208581 aaccggtaaa caatttattg aatccggaac ctacaagcat gttctagttg ttggtgtaga 1208641 gaagctctca agcattaccg actgggaaga ccgcaataca gccgttctgt ttggagacgg 1208701 agcaggcgct gcggtagtcg ggccagtcag tgatgacaga ggaatccttt catttgaact 1208761 aggagccgac ggcacaggcg gtcagcactt gtatctgaat gaaaaacgac atacaatcat 1208821 gaatggacga gaagttttca aatttgcagt ccgccaaatg ggagaatcat gcgtaaatgt 1208881 cattgaaaaa gccggacttt caaaagagga tgtcgacttt ttgattccgc atcaggcgaa 1208941 catccgtatc atggaagctg ctcgcgagcg tttagagctt cctgtcgaaa agatgtctaa 1209001 aactgttcat aaatatggaa atacttctgc cgcatccatt ccgatctctc ttgtagaaga 1209061 attggaagcc ggtaaaatca aagacggcga tgtggtcgtt atggtagggt tcggcggagg 1209121 actaacatgg ggcgccattg caatccgctg gggccgataa aaaaaggtga ggtgcacaca 1209181 agatgactaa aaaaagagta gttgttacag gacttggagc attatctcca cttggcaacg 1209241 acgtcgatac aagttggaat aacgcaatca acggtgtgtc cggaatcggt ccgatcactc 1209301 gtgttgacgc tgaagaatat ccggcaaaag ttgccgctga attaaaagat tttaatgttg 1209361 aagattatat ggataaaaaa gaagccagaa aaatggaccg ctttacacaa tatgcggttg 1209421 tggctgcgaa aatggcggtt gaagatgcag atcttaacat taccgatgag atcgcgccga 1209481 gagtcggtgt ttgggtaggc tccggtatcg gaggacttga aacactagag tctcaatttg 1209541 aaatcttctt aacaaaaggc ccaagacggg taagcccgtt tttcgtgcca atgatgattc 1209601 ctgacatggc gacaggccag atttctattg cattaggagc aaaaggggtg aactcttgta 1209661 cggttacagc atgtgctaca ggaacgaact ccatcggtga cgcgtttaag gttattcagc 1209721 gcggtgatgc agacgtgatg gtcacaggcg gaacagaagc gccgctgaca agaatgtcat 1209781 tcgccggctt tagtgccaac aaagcgctgt ctactaatcc agatccgaaa acagcgagcc 1209841 gcccgtttga taaaaaccgt gatggctttg tcatggggga aggtgcaggg attatcgttc 1209901 ttgaagaact tgagcatgcc ctggcccgcg gcgctaaaat ttacggagaa attgtcggct 1209961 acggctcaac cggagacgct tatcatatca cagcgccggc ccaagacggt gaaggcggag 1210021 cgagagcgat gcaagaagcc attaaagatg caggcattgc acctgaagaa attgattaca 1210081 tcaatgctca cgggacaagc acgtattaca acgacaaata cgaaacaatg gcgattaaga 1210141 ccgtttttgg cgagcatgcg cataaacttg cggtaagctc tacaaaatcg atgacaggcc 1210201 acctcttagg agcagccggc ggtattgaag ccattttctc tatcctggcc attaaagaag 1210261 gcgtgattcc gccgacaatc aatattcaaa cacctgacga agaatgtgat ttggattatg 1210321 tgcctgatga agcccgcaga caggaactta attatgttct cagcaactca ttaggattcg 1210381 gcggacacaa cgcaacatta atctttaaaa aatatcaatc ataatcaagc caaaccggct 1210441 gcccttaaag ggtagccggt tttttttgtg tgcataggat taaaagagga ggcgatcaca 1210501 tgagtgtaga acaaacatat agctggctca ggaaggccgg ttcaatagat gatttggcgc 1210561 attacattat cccgcttttt tcaggtgcgg agaaaaagaa ctggaagggc attctggggc 1210621 atcttcagca tcatgggatg tttaaaaaca taaaagaggg tattcagacg gtttccaagc 1210681 tgaaggaaaa aggtttttac ggacatatcc aaaaggaaga acagtacctc aaaaacaaat 1210741 ggcaaggtcc tgatgtacca attgttacgc tgccggttga tgaacgaaac aggagaatcc 1210801 gtttagaatt cggatcaaaa tcaggactcg cctttcaaga caaaatgttc ctttttcttt 1210861 cgtcagattt agattttggg tcggtatctg cccttatgac gcatgagtat catcacgttt 1210921 gccggttagg tcatctgaca aaagaggaaa aggatgtcac attacttgat acaatcatca 1210981 tggaagggct ggcggaatat gctgtttatg agaggttcgg ccgaagtcaa acggctgaat 1211041 ggacgacttg gtatacaccg gaacagcttc aggctttata tgaaaaaaag attgcgcccc 1211101 atcgggatat caaacgggat aatcgattat ttccccagct gttattcggc aaaggatatc 1211161 agccaaaaat gcttggatac gcagttggat tcaatattgt aaaaaaatat ttaaccgcca 1211221 gcaaggcaag caccgcagac gggctgtcca ttcctgctga gacctttttg gatgcaatgc 1211281 tttaaaagga taaaataatg gaatttcatt aataatatta catttatcct aaaaaattct 1211341 tgattttgca aaatgattgt aataatatac aactataaaa tttttcgata attcaatatt 1211401 atttattatt tctgaataaa gggattgctt tctcttgaaa acgtttgaca acaagagggg 1211461 ggaaagggga gctagcatga gcacactttt agaagtgaat aatttaaaga cttatttttt 1211521 caggaaaaag gagccgatcc ctgcggttga cggagtcgat tttcacatca gcaaaggcga 1211581 aaccgtcgcg cttgtaggtg aatcgggctc cggaaaaagc attacttctt tatcaattat 1211641 gggcctcgtc caaagctcag gcggaaaaat catggacggc tctattaaac tcgaagacaa 1211701 agacctcacc tcattcactg aaaacgatta ttgcaaaatc cgcggtaacg aagtatccat 1211761 gatctttcag gaaccaatga cctcccttaa tccggtgtta acaatcggag aacaaattac 1211821 cgaagtgctg atttaccata aaaacatgaa gaaaaaagaa gcccgtcaac gagctgttga 1211881 actcttgcag atggtcggtt tctcccgggc ggagcaaatt atgaaggagt acccgcatcg 1211941 gctgtccggc ggtatgagac agagggtgat gattgccatc gcactgagct gtaatcctaa 1212001 actgctcatt gctgatgaac caacgacagc gctggacgtg acaatacaag cccaggtgct 1212061 ggagctcatg aaagatctct gtcagaagtt caatacatcg attcttctca tcacacacga 1212121 cttaggtgtc gtgtctgaag ctgccgatag agtgattgtc atgtactgcg gacaagtcgt 1212181 agaaaacgcc actgttgatg acttattttt agaaccgctt catccgtata cagaaggcct 1212241 gcttacgtca attcctgtta tagatggaga gattgataaa ttaaatgcga ttaaaggcag 1212301 tgtgcctaca ccggataatc tgccgccggg gtgccgtttt gccccaaggt gcccgaaagc 1212361 tatggataag tgctggacaa atcagccttc gcttttgaca cacaaaagcg gaagaacggt 1212421 gagatgcttt ttatatgagg aagagggtgc cgaacaatca tgacagcagc taatcaagaa 1212481 acaatcttag agcttcgtga cgtaaaaaaa tactttccga tccggtcagg cctttttcaa 1212541 agaaaagtcg gtgatgtaaa agcggtggat ggtgtttcat tttcgttaaa aaaaggagaa 1212601 acactcggaa tcgttggaga gtcgggctgc ggaaaatcga ctgccggcag aacgatgatc 1212661 agactgtaca aaccgacaga gggccaaatt ctttttaaag ggcaggatat ttccaatctg 1212721 tcagaggaga agctgcggaa gagtgtccgc aaaaatattc aaatggtttt ccaagatcca 1212781 tttgcttcgt taaacccgag aaagaccctg cgttccatca taaaggagcc gtttaatacg 1212841 cacaacatgt ataccatgcg tgaacgaaac gaaaaagttg aagagctgct tgcaagagta 1212901 gggcttcacc cgtcgtttgc cggccgttat ccccatgagt tttcaggcgg ccagcgtcag 1212961 cggatcggca ttgccagagc actcactttg aatccagagc tgatcattgc agatgagccg 1213021 gtttccgcac ttgatgtatc cattcaggcc caagtgatta acttgatgga ggaattacag 1213081 gaagaattta atcttacgta tctatttatc tctcatgatc tgagtgtcgt ccgccatatc 1213141 agcgacagag tcggagtaat gtatcttggc aaaatgatgg aactgaccgg caagcatgag 1213201 ctttatgaca acccgcttca cccatatacc caagcgcttt tatcctccgt tccggttaca 1213261 agaaaaagag gttctgtcaa acgtgaacgc attgtcctga agggagaact gcctagtccg 1213321 gccaacccgc caaaaggctg cgtattccac acaagatgtc ctgttgcaaa accgatatgc 1213381 aaggaacaaa taccagaatt taaagaagct gctcccagcc actttgtggc ttgtcacctt 1213441 tatagctaat gttgcccgca cagctttgag agggggtatg cacactacat aaacaacagc 1213501 ctagaagaac gaacatttca agagggggaa tatctaatga aaagacggaa aaccgcactg 1213561 atgatgctaa gtgtattgat ggttctggcc atctttttat cagcctgctc gggatcaaaa 1213621 tcaagcaaca gcagcgcgaa aaaatcagca ggcaaaccgc agcaaggcgg ggatttggtt 1213681 gttggttcaa tcggagaacc cacacttttt aactctctgt attctaccga tgacgcaagt 1213741 acggatattg aaaatatgct gtacagcttt ttaacgaaaa cggatgaaaa actaaatgtg 1213801 aaattgtcac tcgctgaaag cattaaagaa ttagacggcg gccttgcata tgatgtgaaa 1213861 attaaaaaag gcgttaagtt tcatgacgga aaagaactga ctgcagacga cgtcgtattt 1213921 acgtacagtg tccctttaag caaagattac aagggagaac gcggttcaac atatgaaatg 1213981 ctgaaatccg tagaaaaaaa ggcgattacg aagtcttgtt taagctgaaa tataaagacg 1214041 gtaatttcta caacaatgcg ttagacagca cagctattct gccgaaacat attctcggta 1214101 atgttccgat tgctgattta gaagaaaatg agtttaacag aaagaaacca atcggttcag 1214161 gaccatttaa gtttaaggaa tggaagcagg gccaatatat taagctcgaa gcgaatgatg 1214221 attactttga aggaagaccg tatttagata ctgtgacgta taaagtcatt cctgacgcaa 1214281 atgctgccgt tgctcagctg caggcaggcg atattaattt ctttaatgtg cccgccactg 1214341 actacaaaac ggctgaaaaa ttcaacaacc taaaaatcgt tactgatttg gcattaagtt 1214401 atgtgtacat cgggtggaat gaaaaaaatg aattattcaa ggataaaaag gttcgtcaag 1214461 cgctaacaac cgctcttgac cgcgagtcaa tcgtcagcca agtattagat ggagacggcg 1214521 aggtagctta cattccggaa agccctttat cttggaacta tcctaaagat atagatgttc 1214581 cgaaatttga gtacaacgag aaaaaagcga aacagatgct tgcagaagcc ggctggaaag 1214641 atacgaacgg tgacggcatt ctggataaag acggaaagaa attctcgttt acccttaaaa 1214701 cgaaccaagg aaacaaagtc cgtgaagaca tcgctgtcgt cgttcaggaa cagctgaaaa 1214761 aaatcggcat tgaagtgaaa acccagatcg ttgaatggag cgctctcgtt gaacaaatga 1214821 atcctccgaa ttgggatttt gatgcaatgg tcatgggatg gagtttatcc acattcccgg 1214881 atcaatatga tattttccat tcaagccaga ttaaaaaggg tttgaactac gtttggtata 1214941 aaaatgccga agcggataaa ctcatgaaag atgcaaaatc aatcagtgac agaaagcagt 1215001 attcaaaaga atatgagcaa atctatcaaa aaattgcgga agatcagccg tatacgttct 1215061 tgtattatcc taacaaccat atggcaatgc cggaaaatct tgaaggatac aaatatcatc 1215121 cgaaacgtga tttgtataat attgaaaaat ggtggcttgc aaaataaatt tcccttaaag 1215181 gggagggaga gcgttttctc cctcttctgt ttttaataag gaaagtaaag ggggacaagt 1215241 atatggctgc atatattatc agaagaacct taatgtctat cccgatttta ttgggaatta 1215301 cgattttatc atttgttatc atgaaagccg cgcccggaga tccgatgaca ttaatgatgg 1215361 acccgaaaat cagccaggct gacagagagc agtttattga aaaatacggt ctgaatgatc 1215421 ctcagtacgt tcaatattta aagtggctag gcaacatggt gcagggtgat ttcggaacgt 1215481 ctattgtcag aaaaggaacg cctgtttcag aattgattat ggcaagacta cccaatacgc 1215541 tcctgctgat gctggtttca acgattttgg ctcttatgat ttctattccg ttcggtgtcc 1215601 tgtcggcaaa gcggccgtat tcaaaaatcg actatggcat tacatttacc tcgtttatag 1215661 gcctggctat tccaaacttt tggtttggat taattttgat tatggtgtta tcggtaaatc 1215721 tcggctggtt tccaactggg ggtgtcgaga cactgaatac cgaattcaat atatttgacc 1215781 ggattcatca tttaattctg cctgcattcg ttctagctac agctgacatg gccggactga 1215841 cgagatacac gagatccaat atgcttgatg tattaaatca agattatatt cgcacagcga 1215901 gagcaaaagg atttaaagag aacagagtgc tatttaaaca tggattgagg aatgcattat 1215961 tacccgtcat tacaattttc ggtttgatga ttccttcatt tatcggcgga tctgtcgttg 1216021 tcgaacaaat tttcacttgg ccgggattag gaaagctgtt tgtcgattca gcattccagc 1216081 gcgattatcc ggttatcatg gcaatgactg tgatctcggc ggttcttgtc gttgtcggaa 1216141 acctcattgc agacatcctt tacgcgattg ttgatccgcg gatcgaatat taaaaggagg 1216201 gaaacagaga tgtcagagct gcaaacaact ccctcgccgg agatcaggct gaaagaaaat 1216261 atttcgaaaa agccagaaac aatgacaaag attttctggg aaaaattctc gaaaaacaaa 1216321 ctggccattt taggtgccgt tattcttttt atcattatta tgtctgctgt tttcgcccct 1216381 ttaattgcac cttatcccca agagcagcaa agcctgcttg ataaatataa ggcgccgggc 1216441 cttgaacatc tgatgggaac ggataaattt ggacgtgata ttttcagccg gatcctatat 1216501 ggagcgcgtg tctctttatt ggttggattt gcgtccgtag tcggttcgat tttgatcgga 1216561 acggttttag gagcattagc cggatatttc agaggaatag tggatgctgt cattatgcgt 1216621 gtagttgaca ttgtgttatc cattcctgat attttcttgt tgatcacgct ggtcaccatc 1216681 ttcaagccgg gtgtggacaa attgatttta attttctgtc tcacaggatg gaccacaaca 1216741 gcacgattag taaggggaga attcttgtcg ctccgttcaa gggaatatgt tcttgctgct 1216801 aaaacaattg gaacaaaaac gcacaaaatt attttttctc atatcctgcc caatgcgtta 1216861 gggccgatta tcgtgtcagc tacgctgaaa gttgggtctg ttattctagc tgaatcggcg 1216921 ctaagctact tgggctttgg aatccagccg ccaatcgcta gctgggggaa catgcttcaa 1216981 gacgcacaga atttcacagt aatgattcaa gcatggtggt acccgttatt tcccgggcta 1217041 tttattttaa tgaccgtttt atgcttcaac tttgtcggtg atggcctgcg ggatgcgctt 1217101 gacccgaaaa atattaaata aaaatgaata tcatatctgt tataaaatat caccaaatca 1217161 gaaaaaagca ggtctccttt agtcagaaaa tatacaaaga gatctgcttt ttatgattct 1217221 tacataaacc cagtgattcc agatttcctc aatctctttg gaataatttc tctatccctt 1217281 gcctatactg tggacaacag tttttataaa agtgaggggt tagagatgtt atttcttcat 1217341 gatgtgtggg tcaattggtt tgaaggggaa gaaaatggct acaatgtatg ccactttcac 1217401 gaatggcgca aggaagatac ggttgagctt ttggatcagg tgccgctgtt aagggtgccg 1217461 tcagtactgt ttcattacat agaaaacgat ttgtcagagc ttccgaaagg tttgcttgaa 1217521 gacgtacatc agaaatcgta cattcgaaaa aatcatgagc ggacaaagct tgagtattgt 1217581 tttgtcgtaa cagacggaat cggcatttta gctgttgaca cgatcggcta cacgatccct 1217641 gtcagaaaaa gccgtctaat cccaagacag gagcagctcg tttatgaaat ggtaaaagat 1217701 gtagagcctg aaacatatga atttgagcca aagaagctgg aatcctccaa ggaatatcac 1217761 atcttatcat tagcaccaga acatgtcaga ggactgacaa gaaaagaacg gcaaattaag 1217821 cagctgatgt ttatggcgct tgaccaatta aaagggctga aaaaccgagc ggaaattggc 1217881 tactggtaca cagagtggaa tccgcatatg tatgaacaaa tcaaaaggat gagctttgaa 1217941 gagatttggg acatgctgta taacgaaaca attgaaggct ggtcggacaa acacctagct 1218001 ttttgcgaaa acctaataaa aggacagcct tttttcgaaa agctttggga aatggaaaac 1218061 gaatcaaagg tcaactgaaa aaaaccgctc tttgcaaaga gcggtttttt gattagcgtc 1218121 tttttcttcc aagacccatg gcattctcca tttttttcag cattttgttt gctgtccgat 1218181 tcgctcgttc cgcgccttca tcaagaatcc ggtctaattc ttcagattct atcagctcgt 1218241 aatagcggtc ctggatcggt tttaatgcgt tcactacgac ttctgccaaa tcacctttaa 1218301 actcgccgta gccttttcct tcgtactttg cttcaagctc ttcaattgtc gtattgccga 1218361 ggattgaata aattgtaaga aggttggaaa cgcccggttt gttttcctta tcaaatttga 1218421 caatgccttc agaatccgtt actgcgcttt tgattttctt ttcaagctgc ttcggctcat 1218481 ccagcaatgt aatataagct ttctgattcg gatcagattt gctcattttc ttcagcggat 1218541 cattcagaga catgatacgt gcaccgactt ttggaatttt cacttccgga atcgtaaaga 1218601 tgtcgttgta ttttttgttg aagcgttctg caagattccg cgtcagctca aggtgctgct 1218661 tttgatcctc gccgacaggt acaagatccg ttccgtacag cagaatatca gcggccatca 1218721 gcggcggata tgttaacagg ccggagacga cagcttcatt gcctttggat ttgtccttaa 1218781 attgagtcat ccgctcaagc tcgccgatat aggcgacaca ctgcatcatc catccggcct 1218841 gcgcatgtgc ggggacctct gactgaataa acaatgttgc tttttctgga tcaagtccga 1218901 cagctaagta aagcgccgcg agattgcgga tattctttct aagctcaagc cggtcttgag 1218961 gaacagttat cgcatgctga tcgacgatgc aaaaatagct gttataatca tgctgcagtt 1219021 cgacaaactg cttcattgca ccgatatagt tgccgagcgt cactgagccg cttggctgaa 1219081 tgcctgaaaa aatcgtttgt ttcatgaaaa catcaacctc atttcttaaa acataataaa 1219141 aaaggctcat tcttcccctg taaaaaaggg acgaatgaac cgtggtacca ccctgattat 1219201 tccattaaaa tggaatcact ctgacgtttg taacggagac tgctccggct gagcctactt 1219261 ttttccagtt cggtcagctg ctccaaagtc cattccacat tgcccgttat ctgctcccag 1219321 caccgcagac tctcttcaaa caggtgaaac gtgtactact ctttttcata gcaagctttt 1219381 cttttgattg cttcattata aatcaattat aaccaattgt catcatgaaa aaacattctt 1219441 ttttccagta aaattgtaat aatataaata acacgagtgc tgtaaaatcc ttaaatgata 1219501 actgctatca gcgtaaaaac aggcagatat tatatgtaaa aagcaatatg ggcagaaaac 1219561 acatgaaaaa gtttttaatc aatttatgct ttaaatggta gaaggatatt atgttcatgg 1219621 aagaaaaact aacgaagttt aaatatttta aattgataaa ataatattgc aataaattat 1219681 ttgtttcatt ataatgaact tgttcactct attgttacag cttttttaca aaaataatca 1219741 gaaaagacgg aacagaataa aagttgtgga aactcaggtt catttgtctg atatttctga 1219801 ggatttagcc gtaaggagct gaaaattatt attagggggt ttgcgaatat gaaaaaacgt 1219861 tggtcgattg tcacgttgat gctcattttc actctcgtgc tgagcgcgtg cggctttggc 1219921 ggcagcggat caaacggtga agggaaaaag gacagtaaag gaaagacgac acttaacatt 1219981 aatattaaaa ctgagccgtt ctccttacat ccgggattgg caaatgattc agtatcaggc 1220041 ggtgttatcc gtcagacttt tgaaggattg acacgtatca atgcagatgg tgagcctgaa 1220101 gaaggcatgg cttctaaaat tgaaacgagc aaggacggaa agacatatac atttaccatt 1220161 cgtgatggtg tgaaatggtc taatggagac cctgtaactg cacaagattt tgaatatgct 1220221 tggaaatggg cgcttgaccc taataatgaa tcacaatacg cttaccagct ctactacata 1220281 aaaggtgctg aagcggcgaa taccggaaaa ggcagcctag acgatgtggc agtaaaagct 1220341 gtgaatgaca aaacgctgaa ggttgaatta aataacccga ctccatattt cactgaatta 1220401 actgcgttct atacgtatat gccgatcaat aagaaaattg cagagaaaaa taaaaagtgg 1220461 aatacaaatg ccggagatga ttatgtatca aacgggccgt tcaaaatgac ggcatggaaa 1220521 cacagcggct ctattactct cgaaaaaaat gaccagtatt gggataaaga caaagtcaaa 1220581 ctgaagaaaa tcgatatggt tatgatcaac aataacaata cggaactaaa aaaattccaa 1220641 gctggcgaac ttgattgggc cggtatgccg ctcggacagc ttccgacaga atccctgccg 1220701 accctgaaaa aagacggttc tttacatgtt gagccgattg caggagtgta ttggtacaaa 1220761 ttcaacactg aagctaagcc attagacaac gtcaatatcc gtaaagcttt aacatattcg 1220821 cttgaccgtc agtcgattgt taaaaacgtt acgcaaggag agcaaatccc ggcaatggct 1220881 gcagtgccgc ctacaatgaa gggatttgag gataacaaag aaggatactt caaagacaat 1220941 gatgtcaaaa cagcaaaaga ataccttgaa aaaggcctaa aagaaatggg cttaagcaag 1221001 gcatctgatt tgccaaaaat caaattgtct tacaacactg atgacgcaca cgcgaaaatc 1221061 gctcaagcag tacaagaaat gtggaagaaa aatttaggcg ttgatgttga gcttgataac 1221121 tcagagtgga atgtctatat tgataagctc cacagccaag attatcaaat cggccgtatg 1221181 ggctggctcg gcgacttcaa tgatcctatc aacttccttg aattgttccg cgacaaaaac 1221241 ggaggaaata acgatacagg ctgggaaaat ccagaattca aaaagcttct gaatcagtca 1221301 caaactgaaa cagataaaac aaaacgtgca gagctgctga aaaaagcaga aggtattttc 1221361 attgatgaaa tgccggttgc cccaatctat ttctatactg atacttgggt acaggatgaa 1221421 aacctaaaag gtgttatcat gccaggtact ggtgaggttt atttcagaaa cgcatatttt 1221481 aaataaggct acgtctgaaa ataaaagacc tcaaggtata tggggagaaa agccccatat 1221541 acctttctta ctgatggagt ataaaaatgt aaaaaccatg gaggtgttcc cccttgctaa 1221601 aatatatcgg aagacgctta gtctatatga ttatcacact atttgtgatt gtaactgtga 1221661 cattcttctt aatgcaagca gcaccgggcg ggccattttc aggtgagaaa aagcttccgc 1221721 ctgaaattga agcaaattta aatgcgcatt atggcttgga caagccgctg tttgtacaat 1221781 atgtcagtta tttgaaatca gttgcaatgt gggatttcgg accgtcattt aaatataaag 1221841 gtcagagtgt taacgacctg atcagttcag gtttccccgt ttcatttact cttggagcag 1221901 aagctattct cctcgcttta gcgttaggtg tattgtttgg ggtcattgca gccctttacc 1221961 ataataagtg gcaggattat accgtcgcga ttttaacgat atttggtatt tcggttccga 1222021 gctttatcat ggcggctgtt ctgcaatatg tgttctccat gaagcttggg ctgtttccgg 1222081 tcgcggggtg ggattcctgg gcatacacct ttttgccttc catcgcactt gcttccatgc 1222141 cgatggcgtt tattgccaga ctttcccgtt caagcatgat cgaagtgtta aacagtgatt 1222201 atatccgcac agcgaaagcg aaagggcttt cccgcccagc ggttacagtg cggcacgcca 1222261 ttcgaaacgc acttttgccg gttgttacat atatgggccc gatggccgca caggtcttaa 1222321 cggggagctt cattattgaa accatttttg ggattccggg gcttggtgca cacttcgtca 1222381 acagtattac aaaccgtgat tatacggtca ttatgggtgt aacggtgttc ttcagtgtca 1222441 tcttgctatt gtgtgtatta atcgtagatg tgttatacgg cattattgat ccaagaatca 1222501 agctttccaa agcaaagaaa ggagcctagg ccatgcagaa cattccaaaa aacatgtttg 1222561 aaccagccgc agcgaatgcc ggcgatgcag aaaaaataag taaaaagagc ctttccctct 1222621 ggaaagatgc gatgcttcgc ttccgcagca ataagcttgc aatggtcggg cttatcatta 1222681 tcgtacttat tatccttatg gcaatttttg cgccgatgtt ctcaaggtat gattattcaa 1222741 ctactaatct cttaaatgcg gataagccgc cttcaaaaga tcactggttc ggaacagatg 1222801 atcttggacg ggacattttc gtccgtacat gggtaggggc gcgaatctca atctttatcg 1222861 gtgttgcagc tgctgttctc gatttgctga tcggcgtcat ttgggggagc atttcaggct 1222921 tccgcggagg aagaacagat gaaatcatga tgcgtatcgc tgatatcctt tgggcagttc 1222981 cttcattatt aatggttatc ttactgatgg ttgttcttcc gaaaggtcta tttacgatta 1223041 ttattgccat gacgattaca ggctggatta atatggccag aatcgtgcgc ggacaagtgc 1223101 tgcagctgaa gaatcaggag tatgtgcttg cttcacagac actgggtgca aaaacatccc 1223161 gtcttctatt taaacatatc gtgccaaacg caatgggttc tattttggtc acgatgacac 1223221 tgacagttcc tactgcgatt tttacagaag cctttttaag ctatttggga cttggtgttc 1223281 cggctccgct ggcaagctgg ggaacgatgg cttctgacgg attgcctgca ttgacctatt 1223341 atccgtggcg tttattcttc cctgccggat ttatctgcat tacaatgttt ggttttaacg 1223401 ttgtcggcga cggattaaga gacgcattgg atcctaagtt acgtaaataa gggagtgata 1223461 cgggtgacac gcctattaga agtaaaagat ttagcaattt catttaaaac atatggcgga 1223521 gaggtccagg cgatccgcgg agtgaatttc catctggata aaggggagac gctggccatt 1223581 gttggagaat caggttccgg aaaaagtgta acctctcaag cgattatgaa gctgattcca 1223641 atgcctccgg gttatttcaa acgcggtgag atcctgtttg aaggaaagga tctggtgccg 1223701 ctgtccgaaa aagaaatgca aaatgtccgg ggaaaagaga tcggcatgat attccaagat 1223761 ccgatgacct ctttaaatcc aacgatgaag gtcggtaaac aaattacgga agtgcttttt 1223821 aaacacgaaa agatctcgaa ggaagcggct aaaaaacgcg cggttgaact gctggaatta 1223881 gtcggtatcc caatgccgga aaagcgggtg aaccaatttc cgcatgaatt ttcaggcggg 1223941 atgagacaga gggttgtcat tgccatggcg cttgcagcga atccgaaact tctgatcgcc 1224001 gatgagccga caactgctct tgatgtaacg attcaagcgc aaattttgga attaatgaag 1224061 gatttgcaaa agaaaattga cacgtccatc atctttatca cacacgatct tggtgttgtg 1224121 gctaacgttg ctgaccgggt cgctgtcatg tacgcgggac agattgtaga aactggtacg 1224181 gtagacgaaa tcttctacga cccgagacat ccgtacactt gggggcttct tgcatccatg 1224241 ccgacactgg aaagttcagg agaggaagag ctgactgcaa ttccgggcac gccgcctgat 1224301 ttgacaaacc cgccaaaagg agatgctttt gccctgcgga gctcttacgc gatgaaaatc 1224361 gattttgaac aggagccgcc aatgtttaag gtatccgata ctcattatgt aaaatcgtgg 1224421 ctgcttcatc ctgacgcgcc aaaggtagag ccgcctgaag cggtaaaagc gaaaatgcgt 1224481 aaactggcaa acacgtttga aaaacctgtc ttagtgagag aagttgaatg aattgactga 1224541 aaaactatta gaaatcaaac atttaaaaca gcactttgtc acgccgaggg gaacggttaa 1224601 ggctgtagat gatttatcat ttgatatcta taaaggtgaa acattagggc tggttggtga 1224661 atctggctgc ggtaaatcga caacaggccg aagcattatc aggctgtacg aagcaaccga 1224721 tggtgaggtg ctgttcaacg gcgaaaatgt gcacgggaga aaatcgcgga aaaagctgct 1224781 ggaattcaac cgcaaaatgc agatgatttt ccaagacccc tatgcatccc tgaatccgag 1224841 aatgacagtt gctgatatta ttgctgaagg ccttgatatt cataagctgg caaaaacgaa 1224901 aaaagagcgg atgcagcgag ttcatgaact attggaaaca gtgggattga acaaggaaca 1224961 cgcgaaccgc tatcctcatg aattttccgg cggccagcgc caaagaatcg ggattgccag 1225021 agcgcttgct gttgatccgg aattcattat cgcggatgag ccgatttccg ctttggatgt 1225081 atccattcaa gcgcaggtcg tgaatttaat gaaagaactg caaaaagaaa aagggctcac 1225141 atacctgttt attgcccacg atttatcgat ggtcaaatac atcagtgacc gcattggcgt 1225201 catgtatttc gggaaactgg ttgagcttgc gccggcagat gagctttatg aaaatccgct 1225261 tcacccatat acaaaatcat tgctttctgc gattccgctt cctgatccgg actatgagag 1225321 aaatcgcgtt cgccagaaat atgatccgtc tgtccatcaa ttaaaggatg gggaaacgat 1225381 ggaattccgt gaagtcaaac cgggacattt tgtgatgtgc acggaagccg aatttaaagc 1225441 tttttcatga ttcatcaatc cttcaagaga tttctcttga aggatttttt tgcgtcttca 1225501 tagaaagtga gaatgataac atttacaatt agaggaaaaa gcggaggcga aatacgattc 1225561 aatttctgca taacaaaaat gtttttgcgc tattgctgtc tcaatctttt caatctttag 1225621 caggagtcct cgtcacaatc gttttaatgg tccggatcta tcaaatgact gactccgttt 1225681 ttttggcggg ccttatttta tcgttcatgt cgtttgcgag tatagcagca agcttttgcg 1225741 tctctccggt gcttcgcatt ctcggtttta aaaaggtgct tgcgggagcg aatctgctga 1225801 gagcggtctt tattatactg atggcataca gcgtcactca tcacggacag gcattctttt 1225861 ggattacgct gctgtttgtg ttttgttttt ccttcgcggg cgcttttttt cagccggcaa 1225921 gatttgcgct gctgccgatt attgttccaa agaagcaata tgtaaaagcg aatggtgtga 1225981 tctccctctc gaatcaattg ttcttaacag caggctgggg ccttggaggc cttctgacgt 1226041 acgccgtccc ttttgaactc gttgtcggcg ctgccatttg cctgtttgtt ctatcgggag 1226101 cttccatcag tgtgctgcat gtaaatgaag aagaggctgc aggaactgct gaaacagcat 1226161 ctgtcagaag tatatggaag gatttaatga tcatccctat tgtaagagac attactgtaa 1226221 tggacatgtt agaagctttg gcgggttccg tatggtcatc tgctattctc ctcgcattta 1226281 ctgcggctgt tttgcatgaa acagaggtgt ggtgggggat gtttaacgct tcctatttta 1226341 taggcgcaat tgtcggcagt gtgattgcta ttcgtttttc ttcttttttt gagcggaata 1226401 tgggctatgc cattatgttc agctcgcttg taatgtcggc gctgaccctt ttgttttcat 1226461 tttctccagt cccattttta tgcgctctgg cttgtgctgc aatggggcct ttttatcagg 1226521 tgcgtgatat ttgccaggaa accatgctgc aggaagttat tcccgagcag aaacgaatcg 1226581 gaatcatggc tgcaaaaaat gcgattttga ctccttggtc aggcgtcacc tactccatta 1226641 tggggctagt ggctgatgct gctggtgcga aaatagcttt tatcgcggct gctgcattat 1226701 atatcatgac atttctgatt gcactggcgc agccccgtct ggttcattac aggcgagaaa 1226761 atcgagttca atgagaaaca cttcaaaatg aacggagcag ctggctccgt tttgctgaaa 1226821 aaaaaatgaa accatggcgg aagttcgcac gtctttatag atgtaaggct gtttaaacaa 1226881 gaagaaatgg ggtatatcta aaagtatgaa gacaacgaac tcataaggag caaatcaatg 1226941 aactggtatg aaaagcttag cgagtacttt ccaattgaag aaatgaaatc aaaagcgcat 1227001 atggaagctc ttctgaaaga gcgaagcgat atttatcata aagatgaagg caaacatcat 1227061 attttaatgt ttgcggaatt cgattctttt atcttcgttg attatctgta tgtgtctaag 1227121 gatgcaagag ggcaggggct tggcggcaaa ttgatcgcga agctgaaaaa gaaaaataag 1227181 cccatattgc tcgaggtgga acctgtggat gaagatgata ctgatacaga aaaacgcctg 1227241 aggttttatc aaagagagca tttcaagcat gctcagtcaa ttgggtaccg gcgccggtca 1227301 ttggctacga atgaagtaaa caagatggag attctgtact ggtcaccaaa aacagaatca 1227361 gaagaagaaa ttcttgaagc catgaaacag acatatgaaa acattcatac ttataaagat 1227421 gagaaatggt acggagaatc gtacgaaaaa acggatgagg tcttggaaat catcgatgaa 1227481 gaaaaacaaa aaaatatttt cgatcagtta agctaattga gaataagaac atatcatgaa 1227541 cattaaaaat ttgctggatt gacacatttt tttcttagga tactgttcac acttactttt 1227601 ttatagtata atacctgtaa agattccttt tttagagtaa tttcaattta agaataaaat 1227661 agatgttcat cctactaatt agaggagtga agatgaatgg ttacactata cacatcacca 1227721 agctgtactt catgcagaaa ggcgagagcg tggctcgagg agcacgagat tccatttgta 1227781 gaaagaaaca ttttctctga acctttatca attgatgaaa taaaacaaat tcttcgaatg 1227841 actgaggacg gaacagatga aatcatctca acccgttcaa aagtattcca aaaactgaat 1227901 gtgaacgttg aatctatgcc gctgcaagat ttgtaccgct tgatcaacga gcatccaggt 1227961 ttgcttcgcc gtccgatcat cattgacgaa aaacgtttgc aggtcggata taacgaagac 1228021 gaaatcagac gtttcctgcc aagaaaagtt cgctctttcc aattaagaga agcacagcgt 1228081 ttggcaaact aatagatcgt atcatcaaaa gaaggctgag tcatcagcct tcttttattt 1228141 ttcaacctgc tggtaataaa tgctcgcaag gatgacaaac gcaaccgtca aaatggggag 1228201 gagcgtttcg actgtgccgt gctgcgccat aaaaagcgac agctttttgt ctctgacaat 1228261 catttctccg ccagtataag caagcagccc gcttcccgcg taaatcagaa gcggtatttt 1228321 ctctagtgca atatggatga gtttgctgcc ccaaataata accggaaccg atacacacaa 1228381 tcctataaca acgagagaaa actcaccgtg tgaagctccc gcaactgcga tgacgttgtc 1228441 cagcgacata aagagatctg caagcacaat cgttcgtatc gctctccaca gggaggtgct 1228501 gcttttaatg tgtttcgtgt cttttttttc aatcagcagc tgatatccta aatacagcag 1228561 gaaaattccg ccggcgcact gcaagaacgg aatgttcaaa agatatactg ctgcacttgt 1228621 taatccgatt ctcatggcaa cggcaataaa tgttccgaga ataatggctt gctgtctttg 1228681 cttgtccggc aaatgtctgc tggccatggc aataacaacc gcgttatctc cgccgaggat 1228741 caggtcaatc ccaacaatga cgagcagaga aatcagatag tcatgctcca tgaagcggca 1228801 cctcgctttc agtccttcgc ttgtactact actatatgag acaggtcata ttttatgata 1228861 tcagccgcct gatctgccgt tttttaggca aaggtgcatt tttatttctt ttgtgactgt 1228921 tttatcataa aatagaaata caaaggaatt cacactggcc ttggttaagg ttaagatgtg 1228981 gacggaatgg gtaaagtgta gtaaagtaca attaatcggg agcttagatg tcccttcaac 1229041 atcttatata gaagggaagg ttggcaaatg gaaattgaaa gaattaacga gcatacagta 1229101 aaattttata tgtcttacgg agatattgaa gatcgcggtt ttgacagaga agaaatttgg 1229161 tataaccgtg agcgcagtga agaacttttc tgggaagtca tggatgaagt tcatgaagaa 1229221 gaggaattcg ctgtggaagg cccactttgg attcaagttc aggcactgga caaaggatta 1229281 gaaatcatcg tcacaaaagc ccagctttcc aaagacggac aaaagctcga actgccgatt 1229341 cctgaggata aaaagcaaga accagcatct gaggatcttg acgccttgct ggatgatttc 1229401 cagaaagaag agcaagccgt caatcaggaa gagaaggagc aaaagcttca atttgtcttg 1229461 cgatttggcg attttgagga tgttatttct ctatctaaat tgaacgttaa cggaagcaaa 1229521 acgactttat attcgtttga gaaccgatat tatttatatg tagatttttg caatatgact 1229581 gatgaagagg ttgaaaatca gctaagcatc ctgctggagt acgcaactga atcctcaatc 1229641 agcatacacc gtcttgaaga gtacggcaag ctgattattt cagagcatgc tctagaaacg 1229701 ataaaaaaac actttgcatc atagcaaacc gatttccttc cggaaatcgg ttttttttat 1229761 gcacgaaaat gccattttag agatgtgaaa aatcaaaaac atatagacaa gcagaaaata 1229821 cagcgaacag gagttgatca tcttttccag aaagtatact tcatctggaa aggagagatg 1229881 acaattgttt agtgctgtga ctgaagacgg ccaaatgttt caccttctag gcgctcagca 1229941 aaaccagaaa ttaaagcgga gacggttctt ctgtccggta tgcgggggag agctagctgt 1230001 gaagctcgga cttcaaaaag cgccgcattt tgcccataaa cagaacaagt cctgcgccat 1230061 agacatcgag ccggaaagcg cctaccactt agaaggaaaa agacagctgt atgtatggct 1230121 gaaaacgcaa cgggcttcac caatattgga gccgtatata aggacaatca accaaagacc 1230181 ggacgtcatg gcaagaatca aggagcatat gcttgctgtt gaatatcaat gcgccactat 1230241 cgctccagat gtctttcaaa agcggacaga gggcttcaaa caagaaggaa tcatcccgca 1230301 gtggattatg ggatacagcc gcttaaaacg gactgcttcg tccttttatc agctttcaac 1230361 ttttcattgg cagtttatca atgcaagtcc atacagagaa ctgatatgtt attgtcctga 1230421 aaggcgttct tttctccggc tcagccacat cattccattc tacacaaacc attcttattc 1230481 ctcagtccaa acgatcccta tccatcgggc aggtgcaggc gatctttttt tcactgaacc 1230541 gaaaccctca attcaatatt caggctggac gaaagcgatt caccgttttc gccataaacc 1230601 ccatcggttt aactcaaagg aaacaaatcg ccttaggctg ctgttttatg agaaacgaca 1230661 gacgcctttt tcttttctgc cgactgaagt gtttgttcct gttagaaaag gggcagtttt 1230721 taagagtccg gtttttgtgt ggcaggggtt tctttatttg tttatgacgg atcttggagg 1230781 taaacgtgcg ccaattcgtt tttcagccgt tttgcagcag tgcaaactgc acattcataa 1230841 taagaacatt gcactcaggt ccgaatgcag cgaagagtgt ctttcagaag cggttaaaca 1230901 gtatattgat tttttgtgca agaagggatt tttaagggag actcagaaag aagtatatgt 1230961 gctgaatcag cctgcaggag gcatacactc catgcaggat ctcatagaaa gagaccgcag 1231021 ctgttttata gaatgagttt gtcttatttg gctcacccta agacaaaggt ggtgggcagg 1231081 ctgtgaaagg cacaaaagga aaggtttttc gtgtttttac tgcttttttg gcattcgttc 1231141 tcttcattac tgcatatgat ttgacaaaag gcagtgaaaa accggaagat attcacaaca 1231201 caagtttatt gagaaacagc tgttttttca attggcttga atcaaagaag acgaggggga 1231261 tcaccatggc tgaggaaaaa aaagcaaacc aactgcctga cagaagtgag gtaaaggcag 1231321 aagacacatg gagacttgag gatatttttc ctagtgatga ggcctggaat aaagaatttc 1231381 aagctgtaaa agaattaatt ccgaatttat ctaagtataa aggaaagctg gcagattcag 1231441 ctgatcattt atacgaggct cttacgtatc aagataaagt gatggagcgg ctaggtaggc 1231501 tgtacacata tgcgcatatg cgctctgacc aggatactgg gaactccttt taccaggggc 1231561 tgaatgacaa ggcgggaaac ctgtatacac aggccgcaag cgcgacagct tatttggttc 1231621 cggagatttt atccatagaa gaagacaaac tgcagcagtt cattcttgaa aaagaagaat 1231681 tgaagctgta ctctcatgcg attgaggaga ttacaaagga acgtccgcat gtgctgagcg 1231741 agaaggaaga ggcgctgctt gctgaagcct ccgaggtact ggggtcatct tcaaatacat 1231801 tcagcgtgtt aaataacgca gatataacgt ttccatccat taaagacgaa gatgggaatg 1231861 aaaaacagat cactcacggc aactttatta atttcttgga aagtgaaaac cgtgaagtcc 1231921 gcaaaaatgc gtttgacgca gtgtataaaa cgtacggaca atataaaaac acaatggcca 1231981 cgacgctaag cggcactgtg aaaaaggaca acttctacgc gagagtgaaa aagtacaagt 1232041 ccgcgcgtga ggctgcgctt tctaacaaca gtattcctga ggaagtatac gataaccttg 1232101 ttaagacgat taataagcat ttgccgctcc tgcaccgcta tattgcgcta agaaagaaag 1232161 tgcttgagct tgatgaagtg catatctatg acctgtatac accgcttgtg aaagatgctg 1232221 ggatgaaggt gacatacgag gaagccaaag attacatgct gaaaggcctc gcacctttag 1232281 gggaagaata tgcctctatc ctaaaagaag gactggaaaa ccgctgggtg gacgtttacg 1232341 aaaataaagg caaacgcaat ggggcttatt catcaggagc ttacggcacg aatccgtata 1232401 ttttgatgaa ctggcataat aacgtcaata atctctttac gctcgtgcac gagtttggac 1232461 attccgtaca cagctactat acgagaaagc accagcctta tccatacggc aattacagca 1232521 tctttgtcgc ggaagttgcc tctacgacaa atgaagcgct ccttggcgaa tatttgctga 1232581 acaatttaga ggatgaaaaa cagcgcttat atattctcaa ccatatgctt gagggcttca 1232641 ggggaacggt cttcagacaa acgatgttcg ctgaatttga acatctgatt catacaaagg 1232701 cgcaagaagg cgagccgctt acacctgagc ttctgacaaa tgtctattac gacctgaata 1232761 aaaagtattt tggagacggc atggtgattg ataaggaaat cggccttgaa tggtcgcgta 1232821 ttccgcactt ctattacaat tactatgtgt atcagtatgc gacaggttac agcgctgccc 1232881 aagcattaag cagccagatt ttgaaggaag gaaagccggc ggttgaccgt tatattgact 1232941 tcctgaaagc gggaagctca caatacccga ttgatgtcct gaaaaaagcg ggtgttgata 1233001 tgacgtctcc agagccaatc gaagccgcgt gcaaaatgtt tgaagaaaaa cttgatgaaa 1233061 tggaagagct gctgatgaaa gtcaagcagt cttaaaaaag taagcctgtg cggaaatgac 1233121 gcacaggctt ttttaaaacc ctttaaaggt tttccggtga ttcaagcggt agagggtaaa 1233181 caaaatagac agaaacagca gaggagaggt aatataaagc ggcagcatat gcatcatgcc 1233241 taagatattc aagcagaaaa aaacagcaat gcacacaatt gagatcaaag tagacatcat 1233301 ggcggtcctc ctcgtccttt ttccttataa ggatatgagt gaatgcactt cgttatgttt 1233361 tgtgacaaaa atatgaacat taagcataga ggttgtcaaa agtcgacatc ttttgttatc 1233421 ataaggatgt gaaattgatc acaaacaaac attacccctt tgtttgaccg tgaaaaattt 1233481 ctcccatccc ctttgttgtc gttaagacat atgaaaccgc gcttatcccg gcgcggtttc 1233541 tttagtgcta aaaatggaac gtacgtttgg ttatggcata aaaaaacagc ctcaagcata 1233601 tgcacgcctg cggctatttt tcacatgatt gatattcatc agaataagtg ctgagagact 1233661 tccaaaacat tccgtgtttg gcttccactt tggcaacctt tttagcaaac gccagttttt 1233721 tcatttcttt ttctacctct tcaaggctca ggtcatatac aagagcaatt tccttcgagg 1233781 caacgaagcg gaaatattca ataaaacatt ctaaaggcgg tgtttccgac ggcttcggct 1233841 cgtcgccaag catctcaaat aaaatttctt catatacatc atatgagtag ctgccaggaa 1233901 ctttaagccc ttcatcctca tgctgcgtat taaaaaacgt cagtgtcgga ttaacagaaa 1233961 catccatctc ggcagcaatt ttcatgtcac attgaagcgc cttgaccgcg ctttgagaat 1234021 gcagatcttt tttgaattct tcaagatcga gacttgtatt ttcagcaatc tccaaaagca 1234081 cgttttcatc cgtaatattt ttctttgaaa caaataggct ctcctgcata tttctgagaa 1234141 attgcatgcc ggcttttcgt ccttgcagtt cggctgcttt aaaagcgaga gcagccatat 1234201 aaggcgatga aagcggctga tcctgttcga accagacatt gccgtcacat gacatgccag 1234261 agcggctcgc gatcttttcc catgcttctg cgagaagatg cttttttcgc tttttattta 1234321 aagcggtaag gcttgcggaa gcgataatgc gtaaggtgaa aaaacgtccg tatctgattt 1234381 tcagcttttt gatgacgggc tctaaggacc agcattcagg acataaaggg tctacaaaca 1234441 tataaatttc aagcggtttt tttggatgac cgtggcaatg ggcgaagtat agctcatgct 1234501 gatagtttgt caagatgatc gatcctccgc ttccgtttga ttcaccatat gccttgctgt 1234561 caactccagc cggccaaaca aaaactcacg aatttcgccc tccagcccta catggtccat 1234621 tgcgtccttc atacagctga gccacgcatc agctctctcg tttgtaattg gaaagggaag 1234681 atgccttgct ctgagcatag gatggccgtg ttcctcagta taaagaggag gcccgcctaa 1234741 atactgagtt aagaattgct tctgtttcct ggcggtttct gtcaaatcgc ttggaaaaat 1234801 cggcttcagc aaaggatgag acgcgacacg ctcataaaaa gtatcaacaa gttgcgatag 1234861 aagttcctct ccaatcgctt cataaggtgc gttaaacgat tgtcccatgt tgactactcc 1234921 tttaaatatg gctaatagga atcataaatc ctattgcaaa aagtaatttt ctgtatttca 1234981 ttgtttcatc tagatttatt ttagcaacaa ggcatcattt ctacaaacaa actgcctttt 1235041 atgcgtttga tgactcattt cggctgacag ccggggtttg tatttcatat catatcacat 1235101 aaaaatcagg aatgcgtaag atttcacttc gcaaaaaaac cagagggaaa gagcacctct 1235161 ggttacgcgt aataaactga agttattttt tttacatagt tttgcgtttc ttggaaagga 1235221 ggaatgcctc cgtatcggtc aacattcccc ggtccggcgt tgtaagccgc taatgccata 1235281 gacacattgc cgtcgtattt atccagcatt tgttttaaat atttcgttcc gccctccaca 1235341 ttttgctgcg gatcaagcgg attggaaacg ccaagtgagc ttgctgttga cggcatcagc 1235401 tgcatgaggc ccatcgcacc tgctccgctg accgcttttg cattaaagcc tgattcctgt 1235461 ttgatgacgg cgcggatcag tttttcatca acgccatatt tatcagcggc ttttttaatc 1235521 gcactgtcaa tagagaagtc tcccgaacgg atctgatttg cttcatgttt gtttgaagct 1235581 gaatctgcaa cagctgtttc agtgctttct gccgcttttg tgactgaacc tgaattgctg 1235641 ctcgtatatg agttaagccc atacgctgaa agcagtgacg gcgctgttgt attcgcgctg 1235701 ttcagcatgc tgagcgggct tggcgatgaa gaaggtgctg attgctgaga tgtcagaccg 1235761 tttgtatatt ggctgagcaa agaactgaaa cttgaaagcg ggctttccgt attctgagtg 1235821 tccgagctgc tgcgtgcatt agatatggac tgtaatgcct gaagctgaag taatgctgcc 1235881 caattcgtta cattcacgat gtcattccac cttatataga ctttcgtttt tcttcataaa 1235941 aacgcagaat tttatttttg gtttcgcgct gaggaatgct gaattgctga agcagctttt 1236001 cgaaggcttg tctgccctca tgccaatccg ccgcctcaaa ttcaatttca tagtcctctt 1236061 tatttaaata tcggctgtgg tctaaaacta ttaagccttt ttctgtttct ttttccgcac 1236121 ggtttgttgc taaagatcca aagtattgta tggcatccgt atcgatctga agcttgtgca 1236181 gctggtcctt cacagggccc tcgggaactg aaaatccagc gagatctgat acctctgaaa 1236241 gctgctggtg cgtttccaga agccccacat cagccggctc ctttaatgta aggacatact 1236301 ttccgttttt tctgcggata cgaagcgcag catgtttttg tttcagcgcg aagctgtctg 1236361 tatcaaaata atgattcttt tgatctgtaa aatctttttc tgtcagctgg agtgccgatg 1236421 ctatgttttt gaattcttgt ttggtcagca tgtttttaaa ttcgatttca atctcttggc 1236481 tcatgatgct cttcctttcc gccctgtaaa tcttattttt actattatct ctttagatgt 1236541 taggtttatc aatatcgagc tcgatatgat aaaatgaatc tgtactttgt ttaaaaaagg 1236601 agagcattat gcaaaacaga atcgaaattt tgaatgcaac attatcggat gatcagcttc 1236661 gccttgcctg tcagacagaa ggaaacgaag cggaacgcaa gccgtcaggt caaatgcttg 1236721 ttgattctga ccactttgct tttgtataca tacttgaatt agctgattct tttgaatatg 1236781 tcattataaa ggaacatgta tggccggaac tgaagcaggc ccatgcacaa aaaataccgg 1236841 ttgttttaga ggcaggagac caaacaattg aactggcagg cctgcatgag gagctggaat 1236901 atcttttaga aaatataaaa gataatgcaa actatggaga agaaatggaa gaaaaagtga 1236961 aacgcgtgtt tttatagaaa ctggttcgga attgggggat gtatgatgga tgacaaacaa 1237021 tgggagcgtt ttttagtgcc gtaccgccag gctgtcgaag agttgaaagt gaagctcaag 1237081 gggatccgca cactatatga atacgaggac gaccattcac cgatcgaatt tgtgaccgga 1237141 cgcgtcaagc ctgtggcgag catacttgaa aaagcgagac ggaaaagcat accgctgcat 1237201 gaaattgaaa ccatgcagga cattgctggc cttagaatca tgtgccaatt tgtcgatgac 1237261 atccaaatcg taaaagagat gctttttgcc agaaaagatt tcaccgttgt ggatcagagg 1237321 gattatattg cggaacataa agagagcgga taccgatcat accatcttgt tgtgctgtac 1237381 cctttgcaga cggtatccgg agaaaagcat gttctcgtag aaatacagat ccgtacactg 1237441 gcgatgaatt tttgggcgac cattgaacat tcattgaatt ataaatacag cggaaacatt 1237501 cctgaaaaag taaaactaag gcttcagcgc gcttctgaag cggcttcccg gcttgatgaa 1237561 gagatgtcgg agatcagggg tgaagtacag gaagctcaag ctgccttttc aagaaagaaa 1237621 aaaggaagcg agcaacaata ggtaaagggg aagaagagca tgaaatttgc cgtatcatca 1237681 aaaggagatc aagtttctga tacgctgaaa agcaaaatac aggcgtattt attggatttt 1237741 gatatggaac tggatgaaaa tgaaccggaa atcgttattt cagtcggagg cgacggaacg 1237801 cttttgtatg cttttcacag atacagcgac cgtttggaca aaacagcatt tgtcggcgtt 1237861 cacacaggtc atctgggttt ttatgccgac tgggttcctc atgaaattga aaaacttgtt 1237921 cttgccatcg cgaaaacgcc gtatcataca gtcgaatatc cgcttctcga agtcattgtg 1237981 acctatcacg aaaacgagcg ggaagaaaga tacttagctt tgaatgaatg tacgattaaa 1238041 agcatcgaag gaagccttgt tgctgatgtg gaaatcaaag ggcagctctt tgaaaccttc 1238101 cggggcgacg gcctctgcct gtcaactcca tcaggcagca cagcctacaa taaggcgctg 1238161 ggcggagcga ttatccatcc gtctatcagg gcgatccagc ttgcggaaat ggcttcaatt 1238221 aataaccgcg tgttccgtac ggtcgggtca cctctgcttc tcccatccca tcatgattgc 1238281 atgattaagc cgagaaacga agttgacttt caagtgacga ttgaccattt aacccttctc 1238341 cataaggatg taaagtcgat ccgctgccaa gttgcatccg aaaaagtgcg gtttgcgaga 1238401 ttccgtccgt ttccattttg gaaaagagtc caggattcgt ttattggaaa aggtgaatag 1238461 aaagaggaca tatcgtggag cattttttta tcagaaagaa cattacttcc gctgaggacg 1238521 ggatgactgt aaaagaatat gccggtgaac tgggaatttc gaaacgtctg ctgaccgata 1238581 ttaagtttgg cgggggagac ctgcagatta acggtgagca tgtgacggtc aaatacgttt 1238641 tgaaagaggg agatcttctt atcgtgaagt ttcctgagga gcaggtgagc gagacgctgt 1238701 tggcagagcc tgttccgctc gatatccttt atgaggatga acatgtgctt gtgataaaca 1238761 agcagccgta tgtgtcatca atcccttcga gagagcaccc ctccggcagc attgccaatg 1238821 gaattattga tcattatcaa acaaccggag tgagggcgac agttcatctt gtcacccggt 1238881 tagaccggga tacatcaggt atcatgcttg ttgccaagca tcgatttgcc cactccattt 1238941 tatcgtctgc gcaaaaaaac ggccttgtga aacgccggta tgcggcagtg gttcacgggc 1239001 ggatggcaca gatggaggga acagtcgatg ctccgattgg cagacatcct gacagtatta 1239061 ttgaacggac ggtaacgcca gacggccaga aggctgttac tcatttttac gtcacatgtg 1239121 caaatgatga catgacctcg gtggcattgc agcttgagac tggacgaacc catcaaattc 1239181 gtgttcatat gagctatctc gggcacccgt tgtgcggcga tacactgtac ggcggaacga 1239241 gacaggaaat tggccggcag gctctgcaca gcgagcatct ttcgtttatc catccgctga 1239301 cacaggagaa catgaggttt catgctccac tgcctcagga catgagcaaa ctgataaaag 1239361 gagagaatca ttgattctct ccttttttat atggggcgaa atcttgattc gtcgtaaggc 1239421 agggagcttg gaacagagac ggtttctatt tctggaaagc gaaagcctgt cagttgattt 1239481 ccgaacacgc agcctgtatc aatgttgatg gtgcgattga ccttccgagg ctctttcaca 1239541 ggtgtatgac cgtataccac ccaagccttt ccgttatagg ctgccgccca atcacgcctg 1239601 atgggtctgc cgtccggata tgtttcaccc gtcacgtcac cgtaaagcac aaagtccttc 1239661 actctgcggg tatatttgcc gatatcgtca gctcttatgc cagcatgggc gacaactaat 1239721 tctccattat gtaagatgtc gtaaagcggc gctgtttcgt acagcttcat aaactgttcg 1239781 ctgactgatt ttttctcatc tttggaaagt tcctcaagct ctgccgctgt tgtttcgaga 1239841 ccatgcatca cttttaccgg atttcctttt aagtaacgat ataatttatt gcaatggttt 1239901 cccgggacat aacgcacagc gcctttttcg taagcgccgg ctacaaatcg gatgacctct 1239961 atcgatttgg gccctctgtc agttaaatct ccggcaaaaa caagcaccct gccttcttca 1240021 tggacaggta ctccattttt gattgtatag ccaagctttt ggattaatgc agtcatttcg 1240081 tcatagcagc catgaatatc gctgatgata tcgtaagcca tgcggtctcc tccttaccga 1240141 ttgttttatt tattatgaag caaagtgttg tgagtcatca caagctttta tgtgcaaatt 1240201 atagaagaag aatcattttc taaacaggat taagacctta tcactttatt tttcatcatc 1240261 acccttgtta aaatcgcgtt atgtttttta aaaatgaggt tttgttctct gagtgagaac 1240321 tagcataacc ctgacttaaa aaggaggttc tgattatggc gcatacatct gtcgcatctt 1240381 tagttgttgt acttatcgtt gcatttttga cacccatcct tttgcatcgg tttaaactca 1240441 gcatcccggt tgttgttgct gaaatcatta tggggctgat aattgggaaa agcggcctta 1240501 atttagttgt ggagggtgac acctggctcc agacactctc tatgctcgga tttatctttt 1240561 taatgttttt aagcgggctt gaaattgatt tttcgtcgtt tgagaaagga aagaaaaagc 1240621 agttcctgcc gaatggcaag gaagcgccga atacgtttgc tgcggcatct gttattttcg 1240681 tcggtatttt tattttatca ttgctcttgt cctatgggtt cgtcttggcc ggatttatcc 1240741 aaaatgcatt tttgatgacc ctgattattt caacgatttc attaggcgtt gtcgttccaa 1240801 cattaaaaga agaacggatc atgaattcga atatcgggca gattattttg cttgttgctg 1240861 ttattgctga tttggccacg atgattcttc ttgctgtttt ttcttcttta tacggagagg 1240921 acagcggaaa catgtggctc ctgatgattc tgtttgcggc cggagtggtg ctttactttt 1240981 tcggccgggt cttcaaacat cgctcttttg ttcaatccat gtcaaaaggg acgatccaga 1241041 tcgggacgcg tgccattttt acgttaatca ttgtactcgt tgccctgtct gaatcacttg 1241101 gggcggaaaa tattctcggc gctttcttag cgggggttct tgtttccctg ctttcgccaa 1241161 acaaagaact tgttcagcag ctggactcat tcggttatgg gttcttaata ccgattttct 1241221 tcgtgatggt cggtgtgaag cttgatattt ggactctttt ccaggataaa acaattttaa 1241281 tcatgattcc gctcctgctg cttgcgctgt tagtcagcaa aatcattcct gtcatgtact 1241341 taaagaagtg gtatgataac cgaaccattt tcgcgtctgg tttcctgctg acatcaacgc 1241401 tttcgctcgt gattgctgct gcaacaatcg gccagcagct tcacgtgatc agtacaaata 1241461 tgtcaggagc gctaatttta gtagccgtca ttgcaagtat ttttacgccg atctgtttta 1241521 aaaaattata caaacgggaa gagcagccgg aggagaaaaa gacgattacg ttcattggcg 1241581 ccaatcaaat gactttgcct gtcacactcg aattgccaga ggaagagtat gacgtgcgtg 1241641 ttgtacacgt ctaccaagag aatgcggagg aaaagctgtc agaatcagtg tttgctgttg 1241701 aaacaatttc tgactatgaa cacgagacgc ttgaatcact cggcattttt gaaacggata 1241761 tcctcgttgt ggcgacagga aatgaagata tgaatgcaga cattgcatta cttgcaaaag 1241821 ataaaggcac agaaagagtc attgcaagcg taggatcacc ggagcatgaa gcagctctga 1241881 aggagcaggg aatcagcatc ttttctattc tgctgtcgac aaaaacgctg cttcgcgcac 1241941 tgattgaagc gcctggcgtc atgaagctgc tcacgaacca agagtcttcg ctgtatcaaa 1242001 ttaatatgga gaacagtaaa tatgatggtg tcattttacg ggaattccct ttaacaggtg 1242061 acgtcatctt tgtcaggatc ttcagaggtg tggacagcat cgttcctcat ggggatacga 1242121 ggctgaaact tggagaccgt ttaattgtca ccggatctcg ggggtacgta acggatctta 1242181 agaaaacatt ggaaggataa atcttgacca aataaggatt cgtgttaata tagaggtgca 1242241 gaacaattca atatgtattc gtttaaccac taggggtgtc cttcataagg gctgagataa 1242301 aagtgtgact tttagaccct cataacttga acaggttcag acctgcgtag ggaagtggag 1242361 cggtatttgt gttattttac tatgccaatt ccaaaccact tttccttgcg ggaaagtggt 1242421 ttttttattt tcagaggggg aatgatttgt gaagttttca gaagaatgcc gcagtgcagc 1242481 cgcagaatgg tgggagggga gctttgtcca tccgttcgtt caaggaatcg gtgacggaac 1242541 gcttccgatt gaccgtttta aatactacgt acttcaggat tcctattatt taacgcattt 1242601 tgcaaaggtg cagtcatttg gtgccgctta tgcgaaggat ctttatacaa cggggcggat 1242661 ggcaagccat gcccaaggta catatgaggc ggaaatggcg cttcatcgcg agtttgccga 1242721 gctgttggaa atcagcgagg aagagcgtaa ggcgtttaag ccgtctccta cggcgtactc 1242781 ttatacatcc catatgtacc gttcggtttt gagcgggaat ttcgcagaaa tcttagcggc 1242841 cctgctgcca tgctattggc tctattacga ggttggtgag aaattgctgc attgtgatcc 1242901 ggggcatcca atttatcaga agtggattgg cacatatggc ggtgattggt ttagacaaca 1242961 ggtcgaggag caaatcaacc gctttgatga gctggcggaa aacagcacgg aggaagtgcg 1243021 tgccaagatg aaagagaatt ttgtcatctc cagctactat gaatatcaat tttggggaat 1243081 ggcctatcga aaagaaggct ggtctgacag cgccataaaa gaggtggagg aatgtggagc 1243141 ttcacgccat aacggatgac agcaagccgg tagaagagct agcgagaatc atcattacga 1243201 ttcagaatga agttgatttt attcacattc gggaacgctc aaaatcggcg gcggatattt 1243261 tgaaactgct cgatcttatt tttgaaggcg gtatagataa acgaaaattg gtgatgaacg 1243321 ggcgcgtgga tattgcactt ttctctacta ttcaccgcgt gcagctgcca agcggcagct 1243381 tttcaccgaa gcagatcaga gccagatttc cacaccttca tatcgggagg tcggtgcatt 1243441 cactggagga agcggttcaa gcagaaaagg aagacgcgga ctacgtgctg ttcggccatg 1243501 tgtttgaaac ggattgcaaa aagggtcttg aaggcagagg agtatctttg ctgtcagata 1243561 tcaaacagcg gatttccatc ccggttatag ccatcggggg gatgacgccg gacaggttaa 1243621 gagacgtaaa acaagcaggg gcagacggca ttgctgttat gtcaggaatt ttctcttccg 1243681 ctgaaccttt ggaagcagcc agacgatatt cccgcaagct aaaggagatg cgctatgaaa 1243741 aggcattatg aagcagtggt gattggaggc ggaattatcg gttccgcaat tgcttattat 1243801 ttggcaaagg aaaacaaaaa caccgcattg tttgaaagcg gaacaatggg cggcagaacg 1243861 acaagtgccg ctgccggaat gctgggcgcc catgccgaat gcgaggaacg tgacgcgttt 1243921 tttgatttcg ctatgcacag tcagcgtctg tacaaaggtc ttggagaaga gctttatgca 1243981 ttatccggtg tggatatcag gcagcataac ggcggtatgt ttaagcttgc attttctgaa 1244041 gaagatgtgc tgcagctgag acagatggac gatttggact ctgtcagctg gtattcaaaa 1244101 gaagaggtgt tagaaaaaga gccgtatgcg tctggtgaca tctttggtgc atcttttatt 1244161 caggatgatg tgcatgtgga gccttatttt gtttgcaagg catatgtgaa agcagcaaaa 1244221 atgcttgggg cggagatttt tgagcatacg cccgtcctgc atgtcgaacg tgacggtgaa 1244281 gccctgttca tcaagacccc tagcggagac gtatgggcta atcatgttgt cgttgccagc 1244341 ggggtgtgga gcggaatgtt ttttaaacag cttggactga acaatgcttt tctccctgta 1244401 aaaggggagt gcctgtccgt ttggaatgat gatatcccgc tgacaaaaac gctttaccat 1244461 gatcactgct atatcgtacc gagaaaaagc ggaagactgg ttgtcggcgc gacaatgaag 1244521 ccgggggact ggagtgaaac accggatctt ggcggattgg aatctgttat gaaaaaagca 1244581 aaaacgatgc tgccggctat acagaatatg aaggtggatc gtttttgggc gggactccgt 1244641 ccgggaacaa aggatggaaa accgtacatc ggcagacatc ctgaggacag ccgtatttta 1244701 tttgcggctg gccatttcag aaacgggatc ctgcttgctc ccgcaacggg cgctttgatc 1244761 agtgatctca tcatgaataa agaggtcaac caagactggc tgcacgcatt ccgaattgat 1244821 cgcaaggagg cggttcagat atgatgctac agctgaacgg taaagacgtg aagtggaaaa 1244881 aagacacagg tacaattcaa gacctgctgg cgtcgtatca gcttgaaaat aaaatcgtta 1244941 tcgtggaaag aaataaagaa ataatcggga aagaacgcta tcacgaggtt gagctttgtg 1245001 atcgtgatgt cattgaaatt gtccattttg taggaggcgg atgagcatgt taacaattgg 1245061 cggaaaatca tttcaatcaa gattgctgct gggcacgggg aaatacccat cgtttgacat 1245121 tcaaaaggaa gcagtagctg tttctgagtc tgatatttta acatttgctg taaggagaat 1245181 gaacattttt gaagcatctc agccgaattt tctggaacag cttgatttat ccaaatatac 1245241 gcttttgccg aatacagcgg gcgccagtac tgctgaagaa gcggttcgga ttgcaaggct 1245301 ggcgaaagct tcaggccttt gtgacatgat taaagttgaa gtcatcggat gcagccgttc 1245361 cttgctgcct gaccctgttg agacattaaa agcgtctgaa cagcttcttg aagaaggctt 1245421 tattgtgctc ccgtacacgt cggatgacgt tgtgctggcg agaaagctgg aagagctcgg 1245481 cgttcatgcc atcatgccgg gtgcatctcc gattggatca ggacaaggaa tcttaaatcc 1245541 tttgaatctg tcgtttatta ttgaacaggc gaaagtaccg gtcatcgtgg atgcgggaat 1245601 cggctcgcct aaagatgcgg catacgcaat ggagcttgga gcggatggcg tactgctcaa 1245661 tacggctgta tctggcgctg acgatcccgt gaaaatggct cgtgccatga agctcgcagt 1245721 ggaagcaggg cgcctttctt atgaggcggg ccgaatcccg cttaagcaat acggaacggc 1245781 aagcagtccg ggagaaggtc ttcctgtatg acaggcaggt attcaaggca ggagctgttt 1245841 gctccgatcg gcccatccgg ccagaaaaaa ttgaaagaag cgcgcgccgt gattatcggc 1245901 gccggcgcgc tcggaacagc cagtgcagaa atgctggtga gagcgggagt cggctctgtg 1245961 aaaattgccg acagagatta tgttgaatgg agcaacctcc agcgccagca gctttataca 1246021 gaagatgatg tcaaaaaaga aatgccgaaa gcagccgctg cggagcgccg tctccgttcg 1246081 attaacagcg atgttgatgt gaccggcctt gtcatggatg tgacagcaga aaatatcttc 1246141 gagctgatta gggatgcatc gattattgtg gatgcggctg ataattttga aacccgcctg 1246201 atcgtaaatg atgctgcggt aaaggaaggg attccttttc tttacggtgc ctgtgtaggg 1246261 agctacggtc ttacctttac cgtggtgccg ggttctactc cttgcctgca ttgcttgctc 1246321 gatgcacttc cgattggcgg agcaacatgt gacacagctg gcatcatcag tccggctgtt 1246381 ttgcaggtag cagtctttca ggtaacagat gcactgaaac tgctgacggg agaggagtgc 1246441 gagccggtgc tgcgctcctt tgatttgtgg aaaaacgagc ggtcagaagt gagagcggcc 1246501 agtctcaaac atgacgcatg cccaagctgc ggcacaaagg attttccgtt tttgtcttat 1246561 gaaaatcaaa caaaagcggc tgtattgtgc ggcaggaaca cggtgcagat cagatcatct 1246621 attacgaaag aagcggatct tgaagcgctt gccggtcagc tgaggcaggc cgggcttgaa 1246681 gtagctgcga acccgtattt aatttcctgc cgctcggatg atatgaaaat ggtgctgttc 1246741 cgggacggca gagctttgat ccatggaaca aatgatattg cccgggcaaa atccatttat 1246801 cataaatgga ttgggtaata aaaggagtgt agtgtaatga gtatatataa agcattgaca 1246861 atcgccggat cagattcagg cggcggcgca gggatacagg ctgatattaa aacctttcaa 1246921 gagcttgatg tattcggaat gtctgcgatt acggcggtaa ccgctcaaaa tacgcttggc 1246981 gttcacgggg tgcatccgct gactgtagag acgttgagac agcaaattga cgctgttgct 1247041 gaggatttga gaccggatgc agttaagacg ggaatgctct ggaatgccga catgattgaa 1247101 gaagtggcaa gaaaaattga cgagtacgga ttcaatcgtg taattgttga tccggttatg 1247161 atcgcaaagg gcggggcatc cttgctgcgt gatgagtcag ttgccacctt aaaggagttg 1247221 ctcattccaa gaagctacgc gattacgccg aatgtcccgg aagcagaaac gctgacagga 1247281 atgacaatca gctcgctgga tgaccggaaa aaagcagcgg agcagctcgt caagatgggt 1247341 gcgcagcatg tcattatcaa aggcgggcac cagcctgagg acaatcacat tactgacctt 1247401 ctttttgatg gcagcatgtt tatgcaaatc acccatcctt atatcaatac gaagcatacg 1247461 catggcacag gctgcacctt tgctgcggct ttaacggccc aaacggctaa aggagacagc 1247521 atccatcagg catttgaggt tgcggccaac tttgtccgtg aagcggtgga aaatacgctc 1247581 ggcatcggat cgggacacgg gccgacaaac catttcgctt ttaaacgaaa cagcttaaat 1247641 acaagccgat gagatcacca gctgatggtg atctcttttg cgtttgctac ggtatgcgct 1247701 tttcatctgg acaaggttat gatatgatag gaattaagat caggtactaa tactatgtct 1247761 ttattaaata taggaggctt tatacatatg aatttttcac ttgaaggccg taacattgtt 1247821 gtgatggggg tagccaacaa acgcagcatc gcctggggca ttgcgcgttc tttacatgaa 1247881 gcgggtgcac gtttgatttt cacatacgct ggtgaacgcc tggagaaatc cgttcacgag 1247941 cttgccggaa cattagaccg caacgattcc atcatcctcc cttgcgatgt tacaaacgac 1248001 gcagaaatcg aaacttgctt cgcaagcatt aaggagcagg tcggtgtaat ccacggtatc 1248061 gcgcattgta tcgcgtttgc caacaaagaa gagcttgtcg gcgagtactt aaacacaaat 1248121 cgtgacggct tccttttggc tcataacatc agctcatatt ctctgactgc tgttgtcaaa 1248181 gcggcacgtc cgatgatgac tgaaggcgga agcattgtca ctttgacgta ccttggcgga 1248241 gagcttgtga tgccaaacta caacgtcatg ggtgtagcaa aagcttctct tgatgcaagt 1248301 gtgaaatatt tagctgctga cttaggaaaa gaaaatatcc gcgtcaacag catttctgcc 1248361 ggcccgatca gaacattatc tgctaaaggc atcagcgatt tcaactctat cttaaaagac 1248421 atcgaagagc gtgcaccgct tcgccgcacg acaacacctg aagaagtggg cgatacagct 1248481 gcgttcttgt tcagcgatat gtcccgcggg attacaggtg aaaatcttca cgttgattct 1248541 ggtttccata tcactgcccg ctaagcagga tctatatcaa gcaatcccga atagggattg 1248601 cttttttatt tcttctgatt ttcagctttc tgtcatatag atagaatatg acacaatcgg 1248661 agggatgaag atgtctaata agaaaagaaa cgcggataaa aaaccgctca tgtatattgt 1248721 tcagccggat tatgcagaaa ctacaaggtc atccatgcag gagattgtca tcaaaagaaa 1248781 ggccgacaaa cccgctccgc caaaagctga ggaaaagccg gcttaccatg agaagcagca 1248841 ggaggaagcc gtggcacagg atgtcctgca agaagaccaa aagcctgcag ccgaaccagt 1248901 gagtcagcaa acacaagagg cgagagagcc agagaacata aaaagccaag aggaacagaa 1248961 ggcagagccg caggccgtag aagaaaccgt tgaacacgag cccccgaaag cagaaaaaaa 1249021 ggaagagcct gcacttgagg cccggaagcc tgagaaagaa ccggaagctg tccatagtgc 1249081 tgataaagcg gaggaaaaag caccgccggc acgaaaagtg aaaaaaccga tgagcaagat 1249141 gacgatccac gaaaaaattg attttttaac aaagctgcct cataacatgc cgagagcgct 1249201 ttgtttgatt gaagccaatg gaagaacgta caggggcgtg attgtcggaa gaagaaatga 1249261 ttccgtcctg cttcgaacaa ccggaaacgg agccccaacc gaactggcaa tcgatgatat 1249321 tacctctttg cacccgctcg gtttttaacg aaaaagaaaa aagctgcccg gctgatgttg 1249381 ccggacagct ttttttacat agagaaaagc ctgcaggcct gcaagctttt ccagcttatg 1249441 attaatgatg atgtgtacga ttgattaatc gaggatttaa gcagttgatt gcgcagaagc 1249501 agtctaagtc aacttcaata cagtagttcg ttttttcgag tcggaacact tcacacaccg 1249561 tatctttatc ggtgaagtcc aaaatgtgtt tgtgttcgtc aaatgcgatt aataatgaca 1249621 gtgttgcaca gcttccatgc actctttcga ccctgaaaaa tactgtatta aagcaagggc 1249681 cgttatcgag ttcgccgaca tttccgaagg cgactaatgg cgttgatttt gatgtaaata 1249741 ttgcaaaagg cactgtgtcg cctaacgaat ggcttacaga taaaagctta gagtggcagc 1249801 cggtcgggca gtcttcttca acagcgtttt gcagatcttc aatattttct acagcttcac 1249861 gcacgcagct tgatgttttc tggctcatat tatccctcct gccttataaa tttgagactg 1249921 gcgaaatgat ggagagtcag ctgcctcacg ctggaagcag ctgaatgatt tgcacctgta 1249981 atagagtttg gaaggggatt cctctttaca agtgtttatc cattgtgatg atgcttttta 1250041 tctttgtgag gcgatgttct gtcaactagc tctggtgaca ggcactgaat cgcgcagaag 1250101 catccgagat ccacttcaat gcagaaatct gttttttcta gcccgaagaa atccgggtcg 1250161 caagggtggc aaacacttaa ggtatcgcct ttgacatcga ccgggcgtaa aatagacagt 1250221 gttgcacagc aatcgcataa tttttcgacg cggaagaaaa tggattcaaa gcattgcata 1250281 tcatccacaa atccccctac gtttccgaat gtggagaaca atccgccttt tttatcaaaa 1250341 acgagaaacg gaattgtgtc ttttccagca atcgtagggt ttaaaaggtt ggtatagcag 1250401 ccagtcggac actgttcttc aactgcctcc tgctctgcta aaatcttttc cactgcatcg 1250461 catacacagt tctcatgccg gccatgggtt tttccgcagc tcattgattt cagctccttc 1250521 tttatagggt atttgacttt agtccttaac aacatatgta cccgtgcccc acttggtgtg 1250581 ggtgaacgtc tatatattca tcatatgctt ggaaaataag aaaaagcaga gcgtttttag 1250641 ctctgctttt aggtcctaga ggacaagagt gataactagg atggctacga gtgtatttgt 1250701 tgctgtagaa ataagggttg cgatatcggc atctactgtt gtgacgttta cgccgcggga 1250761 acattcgatg agaagttttt ggcggtttac ttgtttgtta gctgtaagct gtaacaaatc 1250821 ttgtgcgact aattcggcaa ttacgccgtc tgcaattgat gtcagagttg ccgttacgac 1250881 agcggcatta agtgctgtta caactgatgt tacggcttga acgtctgtag atgtaacatt 1250941 gatgtcacaa gaatctctaa taataatcgt ttcatctgaa acttgtttgt tgagatttgc 1251001 ttgagctaga tcttggtcga tgaaggcgtt gtcgttgcca aaaaaaccat tgccattaca 1251061 gcaaacgtcg caatgacatt ttctttcgtg tttttcttta tctttctctt tgtcatctaa 1251121 cggatggtca cagtcaggat caagtgcaac ccaagaatat ggtctgcttt ccatatctat 1251181 tcctcctttt cttttactgt tattaaatga gcgagcctct tattttgact gagtcatata 1251241 tcctgatgaa gaaccctatt ttttatgatt ggctaattgt tatcgttttt ccgtctttgt 1251301 ctgatctgtt caatgagctg ctctctgcgg cttaacggtt ttgtgttctt ttgctcttgt 1251361 gcggctgctt cttctttttt cttcttttgg ttttctatta gcgcttgtga tttagcttgt 1251421 aagtctttta caagatttaa gagcatttct ttttcttcgt ctgatacttt tttcattttg 1251481 tcttttgtga ccccatgttt agaaaatata ttttggacca gcattttcgt cattggatca 1251541 acttctggaa gctttgcaag ctcttctttg aatttatcgt tatctgacat ttgttttcac 1251601 ctcgtctttt aagtttgtga aaagaaaggg ttaaaggacg tcaagttcac taagaatgct 1251661 gtttaacacc tgaagcaaga tttgtacaaa ggttattatc tcgtcggcag acaaagtaat 1251721 tttgatgttg cggctgttga taattttaat gatggttctt tttttgattt gggagctatc 1251781 gagaataaga atttcacttg ccactgcgtc agccaaatcc tcgtcggcga tgacgagctg 1251841 agtcgccacg ataatcatgg ttgtcacaaa ggcttgtata gaaagggcag ctgttatatg 1251901 tgacgtgtca attgtgatat tttcgcaatc aatcacttcg atctgctgtt cgaattcgct 1251961 tgataattgc tcaaatattg cagggtgcag ggattcgact ttttcttcaa atgacataac 1252021 cttcactcct ttcttatcca tactctatat aatgcaaatg gggtgcagag cggaataata 1252081 aaaataacca attttctgcc ggacaagata caattcatga agaatagggt tttggcatat 1252141 atgtgaaggg atcatgattg gcaaaggagt gaacgagtgg ttataaatgg gctgacaatt 1252201 gttcttctat cgcttgcggt ctttcggctc gcccgcctgc tggtgtttga cacgattatg 1252261 gcgccgcttc gcagtctgtt tcatgaagag aaggaagaaa aggatgcgga cgggaacatt 1252321 gaaacctata tcgtgattaa gggaaccggt gtcagggcgt ttattggtga attgctgagc 1252381 tgctattggt gcacaggcgt gtggtgtgcc ggctttttga ttttatgcca ggcggtgatc 1252441 ccgcaagcgg cgcagtggct gattttactt ttggcgatcg ccggccttgc cggcattata 1252501 gaaacgctcg tatcaaaatg gctgcaagaa taaggcgtta ccaccagcaa ctttctgtca 1252561 gaatacgcat aaagtagcat atatgacata aggaaaggaa ggggacaaaa atgaatcagc 1252621 atcataaacc ttcccaaaaa tctccatata cagattcatc gtatcaatca aaaaagataa 1252681 aaaagaaagg ctgcgggtgc ggaaataaaa agaaaaagcc tcaatagcct ggcaaagaaa 1252741 ccggagaact ccggtttttt gtttttttaa cgaggcggtc tcgctcagca tatatcataa 1252801 gcggggggat aaaagtgaat gagtttgaaa aatggataga aggaagatat gaaccacatg 1252861 aacaaaagca aaaagagcat gaagacacga tgggcagtat cagaaaagac ttggatgcat 1252921 ttgataaagc cggtctggaa tttgaagatg agattgaaga gctggctgaa aaaacggagg 1252981 ccttacttaa aaaacatcaa gctcaatatg atcaatcgta aatccgcaaa cgccctatgc 1253041 gaatatccaa gccgatccca gcagctcaca tagtgtatag agagtaaagg aggtgcttat 1253101 ctatgggctt tggatacgga ttcggcggcg gctacggcgg cggctgttat ggcggttatg 1253161 ctggcggtta cggcggcggc tatggttcaa catttgtttt gttggtcgta ttattcattc 1253221 tcctcatcat cgtaggtgca tctttctttt aagatgtatt gaggaagtac gggttataac 1253281 ccgtacttcc ttgccttgtg tttattttta aaaatgttgg aaaagcacat tgtattatgt 1253341 gcattcatac aataccgtat tactccgcca aaaggaggcg cattatggat aatcaatttt 1253401 ttaagaacat cgaaaagaaa acaggtgtga agatgcagga tgtaatgaat cttgccggat 1253461 cactccaaaa cgctaatttt aaagatgaaa atacagtgcg cagtgtgatt aaccgcgtag 1253521 cgcagatggc aaacagacgc gtgccaaaag aattagaaga taaaattgtg gaatctatta 1253581 caagcggaaa agaaaagctt gattttggca cgatttctaa aatgatggat aataaataag 1253641 tggatggcct ggctgactca ctgcagcggg ccttttttta cagtaaaaac ccggcagtaa 1253701 tctgccgggc tgttaatgat gcaagggctg tcttgctttc tgtagcaggg gatacaaaaa 1253761 tcttgagcgg ttggctgttt tgccgcgcct gttagcaggg caagacaaat ataaatgctg 1253821 tttcgcccgg gtcatggcta catataaaag gcgtctttcc tcctcaagag cggcctcgtc 1253881 tccttttctt gccgtttcta atgagaaatc gtgcggaatc gagccatcta cagtgcctaa 1253941 cacgtagact gttttgaatt caaggccttt tgaccggtga atggtcatca gctgaacgcc 1254001 atgttcatcc gttctgtttt tctcagcggc cctcatatgg tctacgtggg caagaaagtc 1254061 aggaatcgtt ttgaacttct tggcgacaac cttgatgtcg cgcaggtcat cagagccttt 1254121 ttccagcttg ttgccctcat tgccccgctt ttttaaatac tcggagaagc ccatttttcc 1254181 ttctgcaaag gtgatggctt ctacgggttt cattgtgcgg aggcttgcaa aaaacggtac 1254241 gattttcttg attttgtcca gctggaatgg cttcagatca ggcaatttgg ccagcgcttt 1254301 gatcatggta cagtcctctg taatcgagag cgccttcagc gtattcaaag cggactgttt 1254361 taaaaacaag gcgggaagca agtgtttaat cgcctcggtg tcatcctcat tttggctggc 1254421 gtacaagtag gcgagaatct ggcggacgat ccgtctgctg taaaacgatt ggacgccgcg 1254481 gtcagctgta tacggaattg acgattgatg aagcctttca tatatagcac ggcctccgct 1254541 gtttgtgcgg taaagaaccg caaagtcttc tggactggct ccattttgaa ttttttcttt 1254601 gatatcggaa acgaccattg tggcttcttc ctcttcatca taaggataaa acagcacagg 1254661 gacctgaatg tcatcgcggg ccgcttcaag cgttttggca tatctgtttt tgttcttttt 1254721 cacaacgata tcagcactag agacgatcgg gtgcgtagac ctgtagttcg cagttaaata 1254781 gatcgtcttc gctcccggat aatccttttg aaaatcaaga atgaaagacg gattgcttcc 1254841 gcgaaacgcg tagatggact ggtcatcgtc tccgacacag cacaggtttt gctccgggct 1254901 ggcgagcatt tgcatgattt tgtattgaac cggattaatg tcctgaaact catcaattaa 1254961 gatatacgta aaccgagatt gatattgttc cagaaggtca ggccgctcga taaacaattc 1255021 atagcaggct gaagccatgt catcaaaatc aaattggctg tgttcttttt tctggcgttc 1255081 ataatgttca tataaacgat aaacttgttt ttcccactca tcttttagag ggatgcgttc 1255141 atttgggaca taagtgtttt tccaaaaacc gatctgctgc agggcttggt caactgggga 1255201 ttctttctca tcgatgcctt cttcatagag tgcttttttg atatattgtt cccgctgcca 1255261 ctccattttc agcagatgct caccgttcca tttagcagaa ttagagtgat acaagatctt 1255321 ataaaacaga ctgtggaatg ttcctgtcac aattcttctg acttttgccg gctgtaatcc 1255381 gtactggttc gccatacgct ctttcatttc agcgacagct tttgttgtaa aggtgacaag 1255441 cagcatattt tcaggcggta tgcctaagtg ttcgatcatg tgggcggcac gggctgtcag 1255501 tacccgtgtt tttccgctcc ccgcacctgc aagcacgagg agcgggccct ctgtttccgt 1255561 gacagctttc agctgatccg tgtttaaacc gacagacgga aaaaggctcg tatcgggttc 1255621 tattgttttt ggcacaaatg gtgttcctgg tttaatgctt ctaggacggt gccattctgt 1255681 aacagctggg gacgggtcag cggcgatcgc ttttcccttg ggtaaacgaa tgacaccaga 1255741 ttcctgatca tcttcttttt tcccctcttt agagggcttc ggttcgcacg cctcctcaca 1255801 tgccggaaaa tcgcctggct ggcgatggat aaactctggc ggatcggcga tgttaagccg 1255861 taacaaaacg ggctttccgc aatgagaaca aaataaatgt ccttttattc cctcttcaaa 1255921 gaggaattga taatgttctc tcgaatatgt atgtaaatgt atgattctat cattcagtcg 1255981 ggcgcatttc aaaaaggggt cctcccaatc aaaaggtgtt cattacagac aatgactatc 1256041 atatcaaaag aaatgtgttt caaaaagtaa gtttaaggga aaagagacag cagaggggtg 1256101 ggtattgtat gatatatgca ggtcaaattc agaaccagca atacgctcaa tatgctaata 1256161 gaacgattgg acataagcag gattatgccg gaaccgaaaa aatcagctat gtcccgtttc 1256221 agcgggtata caaagaactg gaaaagcagc aggagaatca aacggcagct gaaagaaaag 1256281 taaacgagat gaaacgtaag cgctctcttt ataagagatt gcgagaaaaa ggaatgggga 1256341 catatattaa tcgatatgta taaaaaaccg ttcataccag agaacggttt ttttatatgc 1256401 agtaaaaatc cggatctcaa aagatccgga tgcgttcagt ccttcatcat ttgtaagtgc 1256461 ggaatgccgg catcgaggaa ttctttttca gaaagcacgc gatacccgtg tttcttgtaa 1256521 aacggcacag cctgtgtttg cgcgtttaaa atgaaaccgg aagcgcctcc gtctgccgcg 1256581 gctttttcga gcgctttcat aatgatgccg ccgacaccgg ctgagcggtg gcttttcagt 1256641 acgcaaatcc gctctaactt gccgtagccg tccttcatgc gccatcttcc ggcaccgaca 1256701 ggcttttcac cgtcatacac gacgatatgc tctgactcat tttcaagttc gtcaatttct 1256761 tcttcagcag gcacgttttg ttctttgaca aagacttctt ctcttacata gaatgcatct 1256821 ttcagttgtt cttcattttt tgcgataact gctttcaaac attattctcc tctgcctagc 1256881 aagaaggttt catatactgt ccacgatccg ttttccaact ggtagagcaa gtggaaacgg 1256941 tcaacgattt cttcatgcga cacttcctgc atttttaatt gtcccagcac atctgaatgc 1257001 tcatcgtcgg aaagattttg gccgaccgtc acatgcggaa cgaaattata ttcctgttct 1257061 cctgccaaca caccggtgta tagcttttca ttgagtgttt ttaactcttc cgtcggttct 1257121 gctttgatgt aaatgacatt attgacaggc gcaaatgagc tgtattttgt cattttgaga 1257181 acgagtgggt gggactcttt tgcgatgttt cttaaatgtg atacgagctg atccgctttc 1257241 tcctccgcgc attcaaagga tgctctcagc gtcaaatgag gcgggattag agagtagctt 1257301 gggtcatagc gctttctgta agagtttgca aggtcttgga gcttttttga tggaaataaa 1257361 acgattccgt atttcatatt atgtccctcc tggaaataaa gtatgataga gtgttaaagc 1257421 atttttttca gcgccggggt gatgagcggc tgccagtatg tccatttgtg gtctccgtca 1257481 aatggctcga aatcataatc ggaaagcttt ttctccagca gctgtttcag ctcccggttc 1257541 ggttctgtaa agtccagaat gttcccgtct gtcgtgtgga cgtcagtttc ttttgttccg 1257601 atttggtgat aaatagagag gtgtttgata tcgtctgact gttttacggc ttctagtacg 1257661 tgtttgtcaa catagggaga ctgcatgatg atgttgccaa acatattcgg ataatcaagc 1257721 gctgtcataa gtgacacggt tgctccgagc gaatcaccga tcagcgttcg gccgtaaccg 1257781 atctgatagg ttggatactc atcatctgca aaaggaacga gctcatgggc gatgaaccgt 1257841 ttataagccg aaaattttga accctccgga tgataagtgt ttctgcgctc ttttacatcc 1257901 ttatagggaa caccgataat aatgctccgg tctatttcgc gtttcgacag caattcctca 1257961 acctgtctgc cgattctccc cagcctgaaa taatcgtggc cgtcctgcgc gataatgaca 1258021 tggtatttat aaagcgggga gtagttggac ggcagataaa caagcaaggt catttcctcg 1258081 ttaagctctt ttgaaaagaa tttcttttct tgcactgtgc cgtttttcgg tgccataaaa 1258141 acattcctcc aggacatcac tatactttct tgcattttca attattgtac catgaattat 1258201 tagaaatttc tctctttaaa cggttcggca cacgaagaaa aaagtgttga aataaactgt 1258261 gaattgcgct aatataaaac aatcagaaaa ttgaaatcga tatttcttat cgtgagaggt 1258321 ggagggactg gcccttagaa acctcagcaa ccggcttgtt ttgcatttgc aaagcgccaa 1258381 ggtgctaaat ccagcaagcg ttttttatgc ttggaagata agaagaagcg ttaaacccct 1258441 tcttcttatg aagaaggggt ttttattttg aaaagggaag gtgtcagcta tatgtcacag 1258501 cacgttgaaa cgaaattagc tcaaattggg aaccgtagcg atgaagtcac gggaacagtg 1258561 agtgctccta tctatttatc aacagcatac cgccacagag ggatcggaga atctaccgga 1258621 tttgattatg tccgcacaaa aaatccgaca cgccagcttg ttgaggacgc gatcgctaac 1258681 ttagaaaacg gcgcgagagg gcttgccttt agttcgggaa tggctgctat ccaaacgatt 1258741 atggcgctgt ttaaaagcgg agatgaactg atcgtttcat cggacctata tggcggcacg 1258801 taccgtttat ttgaaaatga atggaaaaaa tacggattga cttttcatta tgatgatttc 1258861 agcgatgagg actgtttacg ctctaagatt acgccgaata caaaagcggt gtttgtggaa 1258921 acgccgacaa accccctcat gcaggaggcg gacattgaac atattgcccg gattacaaag 1258981 gagcacggtc ttctgctgat cgtagataat acattttata caccggtctt gcagcggccg 1259041 cttgagctgg gagctgacat tgtcattcac agcgcaacca agtatttagg cgggcataac 1259101 gatctgcttg ctggacttgt cgtggtgaag gatgagcggc tcggagagga aatgtttcag 1259161 catcaaaatg caatcggcgc cgtcctgccg ccatttgatt cgtggcttct gatgagagga 1259221 atgaagacgc tgagcctcag aatgcgccag catcaggcaa acgcgcagga gcttgcggcg 1259281 tttttagaag agcaggaaga aatttcggat gtgctgtatc ccggaaaagg cggcatgctg 1259341 tccttccgtc tgcaaaaaga agaatgggtc aatccgtttt taaaagcact gaagaccatt 1259401 tgttttgcag aaagcctcgg cggggtggaa agctttatta cataccctgc gacccagacg 1259461 cacatggata ttcctgaaga gatccgcatc gcaaacgggg tgtgcaatcg gttgctgcgc 1259521 ttttctgtcg gtattgaaca tgcggaagat ttaaaagagg atctaaaaca ggcattatgt 1259581 caggtcaaag agggagctgt ttcatttgag taaacacaat tggacgctgg aaacccagct 1259641 cgtgcacaat ccatttaaaa cagacggcgg aaccggggca gtcagtgtac cgattcagca 1259701 cgcctcgact tttcaccaat cttcatttga agagttcggg gcatatgatt acagccgctc 1259761 tggcacgccg acaagaacag ctctcgaaga aacaattgcc gcactggaag gcggaacaag 1259821 aggatttgct ttcagttcag gcatggctgc catctcaaca gcatttttac tgctgtcaca 1259881 gggtgatcac gttcttgtga cagaagatgt atacggcgga accttccgta tggtgacaga 1259941 ggtgctgacc cggtttggca ttgagcatac gtttgtcgac atgacggatc gtaatgaagt 1260001 ggcgcggagc atcaagccga acacaaaggt catttatatg gagacgccat caaatccgac 1260061 acttgggatt acggatatta aagcagttgt tcagcttgca aaagaaaacg gctgcctgac 1260121 ctttctggac aatacattca tgacgccggc actgcagcgt ccgcttgatc tcggcgtgga 1260181 tattgtactt cacagcgcga caaaattctt aagcggacac agcgatgtgc tctcaggttt 1260241 ggctgctgtc aaagatgaag agcttgggaa gcagctgtat aagctacaaa acgcgttcgg 1260301 cgccgtcctt ggcgtgcaag attgctggct tgtcctgcgc ggattaaaaa cattgcaggt 1260361 ccgtttagag aaagcgagtc aaacagctca gcggcttgcg gaatttttcc agaagcaccc 1260421 ggcggtcaag cgcgtgtatt atccgggact ggctgatcat cccggcgctg aaacccataa 1260481 aagccagtca acgggagcgg gcgccgtgct atcttttgag cttgaaagca aagaggccgt 1260541 taagaagtta gtcgagaatg tgtcactccc agtcttcgct gtcagccttg gcgccgtgga 1260601 atcgattttg tcctatccgg caacgatgtc tcatgcggca atgcctaagg aagagcgtga 1260661 aaaacgcggt atcactgatg gcctgctccg tctgagtgtc ggcgtcgaac atgcagacga 1260721 tttagaacac gatttcgaac aagcgctgaa agaaattgct ccagtttcgg ttcgttaaaa 1260781 aagaagccgg ggatagtccg gcttctttta ttattgttcg tcatcaggat tcagaatcgc 1260841 gaggacttga tgatcctccc aaacgccatt aatttttaca ttttttcggg cgatgccttc 1260901 tttatgaaat cccgcttttt ctaaaacacg catggacccg agattacggg gcatcacacc 1260961 ggcttcaatc cgatgcagtt tcaattcgtg gaacgcataa tcaacaacca atctgactgc 1261021 ctctgtcata atgccctttc cattatgggc tttgtctaaa aaatacccga tgaacgcagt 1261081 ttgcagcgcg ccacggatga tttgaaagag cgaaaccgtc ccgattaatc tatcgtctga 1261141 cgctgtaaag atgccaaaat gatattcttc atctttctca agtctttcct gatactcggt 1261201 tattcgtttt ctttgcccct caaccgtata gtaatcgtct gcgcgtatca tagaaaactg 1261261 ttcgaaaaaa tctcgatttt cgctttgcag ccccagattt tcttcggcat ccgttacttc 1261321 taaaggtcta acataaatgg tttttccttt taacatatag tgatctctcc gttctcatgt 1261381 cagcattcct cttacattat tctcagggaa atgcaaatat cctttttata agaaggaaga 1261441 aaaccaattt cccataaaag tgccaacata gttgccgatt aagtagccga gcgtaccgac 1261501 aagcatgatc ggggcgacaa gctcccgcca tcccttggca attgccatcg cagccgcagt 1261561 cgtcggtccc ccgacagtag cgttgacggc gagcagaatt tcttcaagcc gcacacggaa 1261621 caattttccg gcagctaagg aaaccgctaa attgctaatc gcaatgataa acacgaataa 1261681 tagaataaga ggcgcattcg tgacgattaa gcggagatct gcaggaatgc cgatcaccac 1261741 aaaaaacaaa taaatcaaaa aggttccaag ctcctgagat ccattgagcc tttcaaaaaa 1261801 acgcgggaaa agaaaaatga taagaacagt taaagacgta agaaccaggt actgatcgcc 1261861 aagcgtaccg gtcagcaggg gatgagaaaa aatgctttta aaataaccgg aaaccttcat 1261921 actaaccgca acaagcgcga aagcggcacc ggcattaaaa gcgatatcct ttaaggaaat 1261981 atccttccgt ttccaatagc tttcagcact gtttccgctg tttccatcgg cttttacctt 1262041 ctcttcaaac ggcatggcat aatgccgctg aaaccatttg agtgcaggaa tgctgattaa 1262101 aataaaaaac aaaagcgcca tcataaaatt atcagccaca acggtagccg acacatattc 1262161 accaggcgtc tcaaattttg ccgccatcgc cgcaaagttg accccgccgc cgatataaga 1262221 ggcgctgatc atcccaccga ttttatctaa gtaaggaata tgctgtttga gtagaaaaaa 1262281 agccaggata ctgccaagca ctgttccaac ggagctaatc agaaaaataa acagcaaacg 1262341 cctgctttcc ttaaaaattt gcctaacatt gatctgaaac aataaaagtg gtatcgccag 1262401 cggtaccaca taagaccaca cagtgtcata cacgggcgac tcaacaggaa gcactcctac 1262461 atttgtaaac accatagcac ctgcaagggc gataatagcg cccgacacag cagacgccca 1262521 cttaaagcgc tgctccagcc cgatgctcac tgccgcccac accgcaataa acccccataa 1262581 tacccataca tcatcagaag aaatcaaaga atgcaaaacc ccatcacctc tattgttaga 1262641 aaattaagac atattataat agccggggaa cggaacagca agtccaaaaa aagtttttct 1262701 aaaaaagcag ttgacgaata gaaggtaagg ttatataata gaacttgtca gaaagataac 1262761 aacataccca gcaacacata catatcatga ttccgtagct cagctgggag agcgctacct 1262821 tgacagggta gaggtcgctg gttcgagccc agtcggaatc atagcttaaa cccttgcgca 1262881 gcaagggttt tttactttgc gttaataaag ccggttcgtc aaattcgtga gttgttggcg 1262941 aactgttggc gaaattcatt gaccgcagtc caaaaactac ctccaaactt acttgattag 1263001 ttcaatagta acaaacggaa gatcggattt ctgttaaatc ttcattgaga atagccagtc 1263061 caagaccgtc acttcagcca tgcatctttt aaatgaaatt ttgtactgaa aacatcaatt 1263121 gtatttttaa attctgctct agaatcagcc cctttataat aatcttgata aattgcttgg 1263181 ggtgatactg attcgtgatt tgtgctatgg tttgcaaggc ttgtagcaaa agcaggagca 1263241 acagtaacga gtaaagcaag ggataatgca aaaccagtta aagctttttc aatttcattt 1263301 taagcacttc tttttttaaa atacaacttt attattaaat ggaatacaaa aacatccaag 1263361 gtgttttttt gttagtaagt tgagttaggg ggattggatg gcacttagaa tattgtttct 1263421 gctgatggga tgttgattct ggatatattt ccaacacgat tacaggccgg acatgaaagc 1263481 gaaccttgct ttgatcgggg caatcatttc atttacggct gcggtttact ttaaagatat 1263541 tgatgtattg agagaagagg gaaaacaaat gaacggaatt tctgagcgtt ggaacacgtt 1263601 taaattacaa aaatcccctg aaccactcta gatcagggga ttgctttccc aacagcttat 1263661 taagtagcgg aaggcatgat caacgattta gtatcaattt attaattgcg aatactagaa 1263721 acataccgtt ttccgccttc cttagaagta acatattctc gaggaacatt aagtctattg 1263781 gtagaatgat aacttacata aagtttcata tttgctcggc tcgttacgat agccgtatga 1263841 tccatccaac catcagcata gcgaagacct attttattat ggtaatcata gtgatataca 1263901 tctccaagct ttacatttga atatgtatca gaaacagtct tcatttttat tccgccagct 1263961 tttaaaatgt atgatctaaa ggctcctgca ttaacccaag catctgtata gggtttccat 1264021 tctttaaagt acggcattct tccagctctt aatgcttggg aaacaaagtt agtacaatct 1264081 ttgtctttat aatatttata gtttttattt ggttttaagg catatttttc tgcatatttc 1264141 attgcagcgt aaccactata tcctttaaca gatgttgcag tcacagttag ttgattagag 1264201 ttagcagcat tgaagttcat acttactggt ttatcttcac ttttcacttc ttctttatca 1264261 tcatttttca cttcttgctt atattttttt aaaaattcat ctaatttaac atccgaagaa 1264321 tattcttcat cattttcata ttgtagagtt gaagaagaat tatttaattg tgttacattt 1264381 agttgcttag aagaattact caatggtatt acatttagtt gattagaaga atttttaact 1264441 tgagagaaac ttagattaga agtatttgtt gattgagaac tttgtttatt agaagttgtt 1264501 ttgggaattt caagtttaat attatcgccc agagatgttg ttactttttc aacaccaaaa 1264561 acaaagtttc gagtaatata agcttcaaca attagcttat tgtttttttc agaagtctta 1264621 acatcgtcta tatcgtatgt aaactcgtgg aatttttgtt tgtccacttt acttaacgca 1264681 gaatacagta agactccttc gtcggaatca gtcaatttag actctttagg atgcgctaaa 1264741 ggagtgttgt gttcaaaatc atatttttgt tgttctaaca tatccttaac tttttcgtaa 1264801 ccaatctcgt tggtaattga aacattttct ttagtctctt tattagtagt ggctgcaaaa 1264861 acttcatttg ttgacactaa tggtgacaat gatagacata aaactagtga agcaagtaat 1264921 tcttttttca tacgaaacct ccaataaaat ctaaatataa gtaatattta tcatttacac 1264981 caattgaaat atggcataaa atacatgtaa taatataaca taaaaataaa tacataaaaa 1265041 ggtatcggag gaaaaaatga aaaagaaaac taaaattata ctttctctct tggcagcact 1265101 tattgttata ttgatagtac ttccagttct atctcctgtt gtctttacag cttcttcgga 1265161 aaaaggagca atcagacacg aaatttataa aagaggatat ccctaccaaa gctactttgc 1265221 agttctccag aaaagagaag gagacaatga atctgggaat ctttattatg taaattggct 1265281 agattggaaa gatgaaacag ggcaaactcc tcacttatgc tattcgaaaa aatcatcaga 1265341 tggtgaatac gaagtaagtt gtggcacagg gccgtaaaaa taaattttaa aattgaataa 1265401 gtccaagacg gaaagcctgc ggacactgat cgttttacag agaaatttgt gcttcgatcg 1265461 gtgtccgttt tttttcgcaa ctaaccagat gtctatcgcg attactagct atgaaaggag 1265521 taattagaca tgaaacagtc caaaaagaaa ccatcacaga agcaacatga gcgcttagat 1265581 cgtttctggc aacaaatgat gaacactaac atgcaaacac tcagacgtgg caaaggcggc 1265641 gcttataaac gcagaaagta aaaagggagt ttgaggatga tgaaaaacgg attcgcttat 1265701 aaaaacggaa agcttgtgaa tatcttttgc ggcaaagaag agctctataa cgagttgaaa 1265761 gccttcttgg tcaaaacctt cagtatcaac gtgaaagagg tatcgaggcc ctcaatatat 1265821 cgcagaacaa aaagcaaaca actggaatga cacttactct atttaactat caggagggaa 1265881 agcactatga cagatcaaat gattgcatgg gagattgagg aatggattcg tgattataaa 1265941 ttcatgctgc gggagatcaa aaggctcaac cgtgtattaa acaaagtgga ttttattagc 1266001 acaaagctca ctgcaacata cggggaggaa gcgggcatgc caaggggatc agcaggcgtc 1266061 agtcaggcag aattgcggca gatggaccga agagaaaggc ggcttcacaa atatgaatct 1266121 attgtgcatt acctggacaa tgcaatggaa cacattgaag aagaaaagca ccgaatcgtt 1266181 tacgattgca tgatggaagg catgagctac actgctattg caaaccacct tgattgctcc 1266241 cgggatacca tcagaaagat caaaacagcc ataatcggca acatcgtcaa taaagtcaaa 1266301 gaagccaact ttctgcaata tttgaattcg tttaaatcgg cggtgtaaaa tggggggcag 1266361 gatcggcgcg gcggattatt cctgcgtcac caccaatttc atacaatgag taaaacctcc 1266421 cagtggtaag cgaggatcaa ctcaactggg aggtcttaca tagtgaatcg gtgataaaac 1266481 agcagcagta ttgcgtacat gttaatatcc ccgacaaaat atgttttttt caacagattc 1266541 gttcgacaaa ttttgcaaat tgttaatcga taacttttca ttcccgatat taaaaatggg 1266601 agtgaattgt aaaatgaaaa aacagaaaaa taataaaaag aagaatattg aaaagcgaaa 1266661 tattgaaaag cgaaatattg aagagaagaa taatgaggac ttagaagaac tggaaaatgc 1266721 gatttatact tatcacaaaa aggagctact tgctttcttt cttgaaaaaa ctcgaattgg 1266781 tcatgataag gaagaataca aaaggttcca atctcttctt tataagttgg atattgaatg 1266841 tttagaattt gctatatcga gattttctca tatagatatt atccatgatc attcaaaata 1266901 tgttccagcc tttatccctt tatttgcagc atatctcacc atgttcttta atttttatga 1266961 aaaacattgg ggagctttat cttttgctgc tggtacaatt gctgctattg tttggataat 1267021 tgcagtagaa agaaaacata gaaatcaagc aatttctatt atgaaaatat ttgaacaagt 1267081 caaagagaga aaagtgaaag acagatctaa agactgaaag gagaaaatat gaataaggat 1267141 aaattaaggt atgcaatctt aaaagaaatt tttgaaggta ataccccttt gtcagaaaac 1267201 gatattggag ttactgaaga tcaatttgat gatgctgtga actttttaaa acgcgaaggg 1267261 tatatcattg gggtccatta ttcagatgat agacctcatt tatacaaatt aggacctgaa 1267321 ctgacagaga aaggtgaaaa ctacttgaaa gagaatggaa catggtctaa ggcctataag 1267381 accattaaag agattaaaga ttggattaaa taataagagc atcctgcggg gtgctttttt 1267441 tgttccctgt aaactgcttc cggtaagtct caggatagac aattggcggt taacggcttg 1267501 agcacggtgg tggtttagag ggaatatctt ttccaaaaca acacgaatca gaagggggcg 1267561 gcggtgaatg tagatggccg aaaagcacat tcaggcgtat aaggattacg tcaaaggcat 1267621 gaaatacaag gaccttgccg agaaatacgg ggtgtcagtg aacaccatta aatcgtggaa 1267681 gcagcggcat ggttgggaaa ggaaaaaggg tgcacccatt gaaaaaagtg tgcacacaaa 1267741 aaaaggcggg caaccgggca acaaaaatgc attagggaac aatggcggcg caccacagaa 1267801 gaatcaaaat gctgtgactc acggcttttt ctctaaattc ttgccagaag agacgcttga 1267861 aatcatggaa gagattcagg agcgttcgcc agctgatatg atatgggatc agatacagat 1267921 tcaatatgcg gccattcttc gggcgcaaaa gatcatgttc gtttctgata aggaagaaat 1267981 gatcaaagag ctgaaaaaga aaaggtccct catatctgag gtcagcgaaa ttgaagatgg 1268041 gcttgtcatt agttttagta cgtggtttcg ctacagactt tacagtgaaa caaacaccta 1268101 acacatttca cattgcttca gattgccttc aaacttgata atataacttc taaaccttcc 1268161 tataaaatga aggtttttta tttgatttca atttttaaat cctttacata cagcgattga 1268221 ttaactcgag caatcaatgt cgcagttata tttatttttc aagaaaatgt tataatgaaa 1268281 agccataaaa tgatgggagg gggaatttcg atgcattaca taacggcatg tttaaaaatc 1268341 atcagtgata aagaccttaa tgagataatg aaggaattca aaaaacttga ggaagaaacg 1268401 aacaaagaag agggttgtat tacattccat gcttatccgc ttgagccatc agaacgtaaa 1268461 ataatgcttt gggagatttg ggaaaacgaa gaagctgtga aaatccattt cacaaaaaaa 1268521 cacacaatag acgttcaaaa acaagaatta acggaagtag aatggttaat gaaaagcaat 1268581 gtgaatgatt gaaaggctct ttaaaaagag acattcaatg acttagtatc agccacttgt 1268641 gactaagtag taaattgttg tccaactctt attttttcta tttaatattt tttgagacga 1268701 aaatgttttt ttaagctgat tttaaaatgt attcaaagtc agctctgttt gatttaatgg 1268761 attatattat ttggatagct tgttaccatc ataatggaga tactccttat aaattggagg 1268821 ttaaaataat gagtcattct caagaaaaaa ttgcactaat tacaggagca agcagtcaag 1268881 gggatattgg tacggctatt tgtcgtaagt tagcctcaca gggtatacat atcttcttta 1268941 ctcactggaa ttctgatacg gcctggatag aagaatttca acaagaaatt ttacgtatgg 1269001 gtgtccgctg tgaggcaatg aaaattgatt tatcagatgc acatgctgca ttcacaatac 1269061 atgaaaaaat ttcagataaa ttaggatatc cttccatcct tattaataat gcagctcatt 1269121 ccgcaagtga taattatgta tcgttagatg ctaaatcact tgatgagcat tatgcggtta 1269181 atatgagatc gaattttctt ctttgtgttg aattcgcccg tcggtttaaa aaatctaatt 1269241 taatatcagg aagaatcatc aatatgacat cagggcagga tttaggtcct ttgcctgggg 1269301 agttagcgta tgcagcaact aaaggagcta tttctgcatt tactaggtcg ttatcacaag 1269361 aacttgcacc attgggcatc actgttaacg ccgtaaaccc aggtccaaca gattctacat 1269421 ggatgacaga tgaaataaga aattttcttt cacctaaatt tccaatgggg cgtattggca 1269481 caccagatga tgcagcacga atgattgcct ttcttgcaag tgatgaggct gaatggataa 1269541 ctggacaaat tattcattca gaaggtggat ttattcgggg ctaagctaat gaaacacggt 1269601 atacaccaat gtatgatgta ttcccaaaac taaatctaaa cttgaagcga aaataaggtc 1269661 ccttctcttt ttagaggggg accttatttt attcatgcat gttttgcatc cagaaaatct 1269721 ggcggataaa gattaataaa ccgttacata tacttttccg aatactgcag tacctttaaa 1269781 caaagtaatc gtggctttcc cttttgattt agccgtcact aaaccatttt gatcgacttc 1269841 agcaactttt tggttatcag tccaataacg agtagctgaa ttatttttaa cagaataggt 1269901 ttctccaact tttagaggta aattatagtc ttgaatcttg ataacatgtg taggtgaaat 1269961 agaaatgttc tttacttcag taggtgtgga gtttatttca tgagctgaag ctaccccgct 1270021 gaccgacaga gctaacgcag aaatcgataa agcagaaaca accgtttttt tgaaattcat 1270081 tttgaaacac tcctttaaag ttttttgtct tgcactataa caattcaata aaagtaatta 1270141 ttttccttgt aaataaatgt taataatatg tgaacgatca attgatttga gctaagaata 1270201 ttgtgtgccc tgcacagagt ttgtatttat gatggaaaat tgctgagaga gaatggccat 1270261 ccttaaaatg ttaatagcac acatttgatg ggtattagtt tgttgagcgt gtggaaattt 1270321 tgttacctgc actttatccc cgaagatacc aaatcacttt tcttcatcat gttcttactt 1270381 tcgtactcat acattagaaa atcttcgttc taaataggtg aagaattgga gtatttttat 1270441 gaatttctgc tgaatataca ttacatagca aactcaaaga gtataaaaat cgcttttttc 1270501 cggaagcttc ggtaaaaaac gaaacttttg tctctatgat tttgttttat aatgtaaacg 1270561 gtttcttata tagtatactt atactatcaa tttgctcaag tagatactga caggaaggat 1270621 agaaaaacag atggaataca taaatacaag acaaaaagag attttgtatc tgttgttatc 1270681 tgaacctgat gactatttag ttgtgcaaga tttcgcagat agggtacagt gttctgaaaa 1270741 aacaatccgg aatgatttga aagtgatcga ggattatctc aatgagcatt ctcatgcaca 1270801 gcttattcga aaaccagggt tgggcgttta tttacatata gaagaacagg aaaggacctg 1270861 gctaagccaa caattacata ctgaacattt ttcttctagg cagcggagcg ataaggaaag 1270921 aatgctgcac attgcttatg acttattaat gaatccgaag cctgtttccg caaaagacat 1270981 tgccgctcgg cattttgtca atcgatcttc cattaaaaag gatttatacg cagtagaaga 1271041 gtggctgaag cgttttgatc tcacactggt ttctaggcag cggcttggat taaaggttga 1271101 agggaacgaa agaaataaaa gaaaggcatt ggcaagaata tctgatttga ttcacaatac 1271161 agcgtttacc agccaattta ttaaaagtaa gtttttacat tatgaagtag actttgtgac 1271221 gaaagaaatc aaatcactac aaaaaaagca ttccctctat ttcacagacg aaacgtttga 1271281 aagtttgttg ctgcatacat tgttaatggt ccgccgcatc aaaatgaagc agccgatttc 1271341 attgtcccca aaagaaatgg cggcagtaaa aaagaagaaa gaatatcaat ggacatttgc 1271401 ttgtttacag cggcttgaac cggtttttgc aattcgcttc cctgaagaag aagccgtgta 1271461 cttaacatta catatattgg gcggtaaggt tcgttatcca ttgcagacag aagagaacct 1271521 tgaaaatgct gtgcttccta aggttgtagg gcatttaatc aatcgtgttt cagagctgaa 1271581 aatgatggat tttcacaagg atcaggattt gatcaatggt ttgaacattc atctcaatac 1271641 tgtgctacaa cggctgagct acgatctttc tgtagcaaat cctatgctca atgacatcaa 1271701 aaagatgtac ccttatttgt tccacctcat cattgatgtt ttggaagaca tcaatcaaac 1271761 ttttgatctt catattcctg aggaagaggc agcatatttg acattgcatt ttcaggcagc 1271821 gatcgaacgg atgcagggca gcagcgagac acataaaaag gcggttatcg tctgccacat 1271881 ggggattggg atgtcacaat tgctgcggac aaaaattgaa cggaaatatc accaaatcgc 1271941 tgtaatggct tgtattgcaa aggccgattt aaaggattat atcaaaaagc atgaggatat 1272001 tgatcttgtc atatccacca ttgcgctgga gaatataacg gttccccata ttgttgtgtc 1272061 tccgctttta gagcctggcg aagagaagaa attaagtgcg tttatacgtc agctgggcga 1272121 atcacaccgc caaaaacaaa aaacgtttca gatgctgaac aatacgactc cttttttggt 1272181 ttttttgcag caggaggcgg agcatcgcta caagttaatc gaacagctgg cgacagcttt 1272241 gtttgagaaa ggctatgttg ataaggacta tgcggttcat gcggtgatga gggaaaaaat 1272301 gtcggctaca aatattgggt caggcattgc cattcctcat gcaaacgcta aatttattaa 1272361 acaatcagca atcgcgattg ccacattaaa ggagccgctt gaatggggaa atgaaaaagt 1272421 ttcgctcgtt tttatgctgg ctgtcaaaca cgaggatcaa actatgacaa agcagctgtt 1272481 tagcgagctt tcatatctta gcgagcagcc ggccttcgtc cagaagctga cgaaagaaac 1272541 caatgtcatg acatttttat ctcatttgga ttattaaaag cagggattat tccttgcttt 1272601 ttttgttata gggaaaaatg cctttattac cggaacctat ggtaaaaaaa gcgattttaa 1272661 tgagctgatt tcggtataca gttgagacaa gatcttatta ttcacacttt aaaggaggtt 1272721 tcctatgaaa ctgttagcga ttacatcttg tccgaatgga atcgcccata cgtatatggc 1272781 agcagaaaat ctgcaaaaag ctgctgacag actgggcgtt agcatcaaag ttgagaccca 1272841 gggagggatt ggtgttgaaa ataagctaac cgaagaggaa attcgcgaag cggacgcaat 1272901 cattattgct gcagaccgtt cggtaaacaa agaccggttt ataggcaaaa aactgctgtc 1272961 tgtgggggta caggacggta tccgcaaacc ggaagaattg attcaaaaag ctcttaacgg 1273021 ggatataccg gtctatcgtt ccgctacaaa atcggaatcc ggtaatcatc aggagaagaa 1273081 acaaaatcca atttaccgtc atttaatgaa cggcgtttca tttatggttc ctttcattgt 1273141 tgtcggcgga ttattgatag cggttgcatt aacgcttgga ggggagaaaa cacctaaagg 1273201 cttagttatt ccggatgatt ccttctggaa aacgattgaa cagatcggca gtgcttcatt 1273261 ttcatttatg attccgattt tagccggcta tatcgcctat agcatcgctg ataaaccggg 1273321 gcttgtgcca ggtatgatcg gcggttatat tgcggcgact ggaagttttt atgacagcgc 1273381 aagcggcgcc ggattcctcg gggggattat tgccgggttt ttggccggat acgcggcact 1273441 ttggatcaaa aaattaaaag ttccaaaagc catccagccg attatgccga ttattattat 1273501 tccggtgttt gcatcactga ttgtaggttt agcgtttgtg tttttgatcg gcgcgcctgt 1273561 agctcaaatt ttcgcctctt taacagtttg gctggcgggg atgaaagggt cgagctcgat 1273621 ccttctggca ttgattttag gggcgatgat ctcatttgat atgggcggtc ccgtaaataa 1273681 ggtggcgttt ctgtttggat cggcaatgat tggagaagga aattatgaaa ttatgggacc 1273741 aattgctgtc gccatttgta tccccccgat tggccttggc attgcgacgt ttttaggaaa 1273801 aagaaaattc gaggcatctc aaagagaaat ggggaaagcg gcatttacga tggggctctt 1273861 cggcattact gaaggagcga ttccatttgc ggcgcaggac cctctgcgcg ttattccaag 1273921 tattatggca ggctcaatga caggttctgt gatagccatg attggcaatg tgggagacag 1273981 agtggcgcac ggcggaccta tcgttgcagt gcttggcgca gttgatcatg tcttgatgtt 1274041 ttttattgct gtgattgcag gatctcttgt cactgctctg ttcgtcaatg tactaaaaaa 1274101 ggatattacg gcgtctcctg tgctcagtga aactgcaccg acctccgcgc caagtgaagc 1274161 tgcggcagca aatgaaataa agcagccaat tcaaagccaa aaagctgaga tgtcggaatt 1274221 taaaaaactg acagacatta tcagcccgga attaattgaa ccaaatttat cgggggaaac 1274281 gagtgatgac atcatagatg aattgattca gaaattgtca cgaagaggtg cgctgctttc 1274341 agagagcggg tttaaacaag ccattttgaa tcgtgaacaa cagggaacaa cggcgattgg 1274401 catgaatatc gcgattccgc acggaaagtc tgaggcggtc agggagccga gtgttgcctt 1274461 tgggatcaaa cgatcaggcg ttgattggaa tagcctggat ggatcagaag ctaaattaat 1274521 ctttatgatt gctgtaccga aagagagcgg gggaaaccag catctcaaaa tactgcagat 1274581 gctatctcga aagctaatgg atgacaatta tagggagcgg ctgctctccg tgcaaacaac 1274641 agaagaagca tacaagctgc tagaagaaat cgaataaagc gggggatttt catgacgact 1274701 gaaccgttat ttttcaagcc tgttttcaaa gaaagaattt ggggcgggac cgctttagct 1274761 gattttggct ataccattcc gtcacaacga acaggggagt gctgggcttt tgccgcgcat 1274821 caaaatggtc aaagcgttgt tcaaaacgga atgtataagg ggttcacgct cagcgaatta 1274881 tgggaacatc acagacattt attcggacag cttgaagggg accgtttccc tctgcttaca 1274941 aaaatattag atgctgacca ggacttatct gttcaggtgc atccgaatga tgaatatgcc 1275001 aacatacatg aaaacggtga gcttggaaaa acagaatgct ggtacattat tgattgccaa 1275061 aaagatgccg agattattta tggccacaat gcaacaacaa aggaagaact aactaccatg 1275121 atagagcgtg gagaatggga tgagctcttg cgccgtgtaa aggtaaagcc gggggatttt 1275181 ttctatgtgc caagcggtac tgttcatgcg attggaaaag gaattcttgc tttggagacg 1275241 cagcagaact cagacacaac ctacagatta tatgattatg accgaaaaga tgcagaaggc 1275301 aagctgcgcg agcttcatct gaaaaagagc attgaagtga tagaggtccc gtctattcca 1275361 gaacggcata cagttcacca tgaacaaatt gaggatttgc ttacaacgac attgattgaa 1275421 tgcgcttact tttcggtggg gaaatggaac ttatcaggat cagcaagctt aaagcagcaa 1275481 aaaccattcc ttcttatcag tgtgattgaa ggggagggcc gtatgatctc tggtgagtat 1275541 gtctatcctt tcaaaaaagg agatcatatg ttgctgcctt acggtcttgg agaatttaaa 1275601 ctcgaaggat atgcagaatg tatcgtctcc catctgtaac atggcagggc ttgagaaata 1275661 aatttgcgag tgaagacgcc tattctccag caatgatcta aataaaataa gagtttaata 1275721 gttggagaag aaatgttaca ctcttttctg tatatggtaa agaatgaaaa aacacgattc 1275781 ggttggtagt ccggatgcat gattgagaat gtcagtaacc ttcccctcct cgggatgtcc 1275841 atcattcttt aatatctttt atgaggaggg aatcgttatg aaattaacga tttactacga 1275901 tggtcagttt tgggtaggcg ttgttgaagt tgtggacaat ggaaagctaa gagcctttcg 1275961 tcatcttttt ggcaaagagc cgagggattc tgaagtatta gagtttgttc ataaccaact 1276021 tttgaatatg atggcccaag ctgagcagga aggagtgcgt ttacaaggca ggcgtcaaaa 1276081 aaagatcaat ccaaaaagat tgcagcgcca ggtttcaaaa gagttgaaaa acgccggagt 1276141 aacttctaaa gctcaagagg cgataaagct agagcttgaa gcaagaaagc aaaagaaaaa 1276201 acaaataatg aaagaacaac gagaacatgt aaaagagcaa aggtatatgc tcaaaaagca 1276261 aaaagcgaaa aagaagcaca gaggtaaata atccaaacaa aagcaggcgc agtgcctgct 1276321 tttgtaatta aggactctac tttgtaacat atatccaatg tttatactcc gctgatttat 1276381 gattcaatat aaaccctaac ttctccaagg ttttttgtga gcctagatta tcatgttcgc 1276441 atcttgcggt gatccgggat actgtttctc ggcttaatgc ccagtttatt agtttttggg 1276501 cggcttccac acaataacct ttgcggcgat gacttttatt tgttgcaaaa ccgatttcaa 1276561 tcatgccatt ttcgtctggg tcacctaaaa atccagttcc cccaacaatt tcataattgt 1276621 ccttctttac aataatccat gaatcaaatc cttttgttcc attgtttttg actaaaatct 1276681 cgcggaaata aggtatcgct tcaaaaaaat cagaatttgg ccattcacca tttgtttcat 1276741 agcctaattc tttgatagcc tgatgatctt gtttagacgc ggcgtcaaga aggggaatat 1276801 caatcgtttg taatcgtaat cgattcgttt caaggagaac catatattta atcctctttt 1276861 ctttttactg ggaataatga taacatataa caattttctc tggtaccttg gcagtagaga 1276921 aagatgaaaa aattgagggg gattgaaaga gtgacaggtg agagtttgcc cagaccaaaa 1276981 acgggtagga aaatgctgat gttaatgtgt ccctacccgt ttttctgttc ctgaatgcag 1277041 ggtttctgat aacatgttgt gctacctttt cgcaatcaaa taaagcgata tggctctttg 1277101 ggtttgcaca ggattatgaa tgataatgac ccattggttt cttcgtcttg gaaagcttgc 1277161 taccgcatac aatggagcag tatcgcgcgg agtgaaccca ccatttatca cgttgatatc 1277221 tcttccttca agatgacaaa ctaagtattc acctggattg atgacctgtt ggttcgtcca 1277281 tgcgtaagaa taaaagccgt ctccaagatc ttcggtggaa gatgggggga caaagccatc 1277341 tacagtcaat gtgatttctc ttcttcgctg tctttctgaa aagtctggac ttctttgagg 1277401 gttatgagta tgtgaaaagt aaggaattaa cgcagggcca taaaagtaat gatacaaagc 1277461 aaccactcct ttattttcca ttcatacaaa ttgtatgtgg gagttatttg ttcattcctg 1277521 ttttgttcca tgtagactaa taatgggcta taggcgtcca aggaaatcaa tttgtccttc 1277581 cgttgattca atgctagtaa ccttgaaaat gcaggttagg atgatagaat ttacatatta 1277641 ctgcaagaag ttagacatac atcattttga tagtgggtga aaacaatggc gaaaaaaatg 1277701 gcaaaaacaa atgcggttcg tctgatagaa cagcagaaca tctcttatga ggtattaggg 1277761 tataaaacag acggccagcc ggtagatggc atctctgttg cggaaaaaat cggttattct 1277821 ttgaaatatg tatataaaac gttggttgca gcagcaggaa caaatcatta ttatgtcttt 1277881 gttgtacccg ttgcagaaga gttagatgta aaaaaggcag caaaggtgac aggggaaaag 1277941 aaaatagaaa tgattgcaat gaaggagctg ttagcggtaa ctggctatct tcgcggcggc 1278001 tgctcgccaa ttggcatgaa aaaattgttc ccgacctata ttgatgcatc tgcagaaacg 1278061 cttgatttta ttattgtcag tgcagggaaa atcggtatgc agctaaagtt ggcgccacaa 1278121 gatttagcca gatcatgtga tgccgcattt gcagaaattg tatagatgca gatatagggg 1278181 aacgaaaaag cttagtcata tcgattaagc tttttccgca tccctttcaa atatgatttc 1278241 aaaataagca gctgccccat acccatctat actgggagcg aaaatctgaa cgaatctcca 1278301 gcctcttttc gcataatcat ggatgatttg ctggtagtct tctttaggcc ttcttctcat 1278361 cgtactcagc tcaactctta cgaattcata ttctttcatc gtttgatccc tcctattaag 1278421 gtatacgtaa aatggagcga gaagttccga aaacctaggt taaggtcgga aagtatattt 1278481 cactcactaa acaaatccat ttatgcctga tgcctgcatg catctgggaa gagttaaggg 1278541 gctataaaaa cgaattttac cgggtcagca gtccaaatga atctcttgct tattgcattt 1278601 gactgagtat ataagtaaaa aaagagcggc cagaacatat aagaaggaga tgatcattaa 1278661 cgcactcata acagggtagt gtttagcgga gtagatgaaa aaatcaagct gtgaaatttg 1278721 tttggggctg ctgacggcat caattccatt aagcagtttt gagagtttag cagtatagtt 1278781 ccaatcaaat cgatctgaaa caagctcgct tccttgatac caattaacag cagctaaaaa 1278841 cagaaatacc ataatagaaa atccaagctg aacaactaaa aatattccct tcacttttgt 1278901 atgacctcca aatctatgaa tatgggaaaa tcaaacaata tattaccacc gtatgggtta 1278961 ttcttgcaat ttcacttcca tacaactcaa acgcaagtct atttttttgt ttgtttttgg 1279021 cttataatac ctgatgatgg aaaaagagtg cgggtttata gattagagaa acaaatgtat 1279081 ttcttagcat tttttatttg tggagagagt atagaagcat tcgattagat ctgctttttc 1279141 acagaaacgg ttttcatctg tttgcctgag ctttacaatt ggctggcaaa aaaacaatga 1279201 tttctttcaa tcaaaacatg caacgatgcg acacatttta tatcttgatg acttatttca 1279261 ttgcctttaa gtcatcctat cgagaaagcg atggtatttt atgaacaaag aaaccctaaa 1279321 aaacatactc atgatttttt caatatgcgc aacactccga gaaaccgatg gtatgcgcat 1279381 agctgatagc tggattttga gtgagattat acgatttttg atttgcatgg ttgtgttttt 1279441 tgccatgaca tttctattag atgctgtttt tccaaacaaa aaagagtcac attaatgtgt 1279501 ggctcttttt gcatcatctg atcagaaaca tcataaatga atcgatcatc atgatgaaga 1279561 acagcaagca aaaataaata agcgagtaga caaacatatc ctttgcccac ttcacgtcat 1279621 cgtctgtttt gaatcctttg atgctttttt tgatccatat gcctccgaga accaaggcgg 1279681 ctaagaaata aaatgggctt atatggccgg tgccgagaga gaaaggaaat aatagcgtga 1279741 ccggcaccag gacggcaata tattgcatca tttttatttt tgttacatga ttgcctttga 1279801 ctactggcaa gagcggaacg ccagcagcgc gatattcctc tttgcgtctt atcccaatcg 1279861 cccaaaaatg cggcggctgc cacagaaaca taatcgtgta caacagcact gctgtcatac 1279921 tgaagtcacc ggttacggca caatacccca tcaatggcgg cgcagctcct gggaagctcc 1279981 cgacaaatgt gctccacaca gacgttcgtt tcacccatac cgtatagatg atcgcataaa 1280041 aaataaaggc ggccagtccg agaaaggccg ttaatggatt gagggaataa agcatggcaa 1280101 gacctgcgat tcctaaaaca gagccatatg ttaagatcat ggctggcggc attttccctg 1280161 tgaccgaggc cctgctgcga gttcgtgcca tttttgcgtc catatgccga tcaaaatagt 1280221 tgttatagac agtgccggaa gccatcacaa acgcggttcc caacattgct gttaccattg 1280281 tcatcaaaaa agccaagccg gttaacgttt tttctgcgct tgcaaacgcg atccaaaacc 1280341 cgccgaaggc tgctatcgag tttgatatga taatgcccgg ctttgcaagt ttgataaaat 1280401 cgtaaatggt tacccggttc gaagctttta tgtattttgt ttcagatatg gctgcagaat 1280461 ctcttgtatt ctccaaaaat agacgcctcc cccaaaactg catgcttttg ttatcgtaac 1280521 aagaggggga cagaatcaca attatttccc atatttgtca tgatattgtc atttttaaaa 1280581 caaaaaaatg gggagctgga ctgcccccat tttgatatgt ggcgactagt aaccgtaacc 1280641 tcccccatat cctccgccat aacctccgcc gtaaccgtac caagggtagt aaggcggtcg 1280701 cgggcgcggg tagtaataag gcgggcgcgg ataaaacggg tagaacggat aatacggtct 1280761 tggataataa taaggcggat aaaatggcgg tctcggacgc ggataataat aaggctgtct 1280821 ttcatcataa ggggtaattt gttcaaatga ctgttcattc aaagggtaat ccaagaggaa 1280881 aacctcccta gcttttttta ttccttttac catattcctg atgcttaagt tgggtgtatg 1280941 tacattcatg aaattcggtt ttttttatga tgaaattcct taaaaaggat tgacatgaac 1281001 ttctaaatct catagtatta caaatgtgaa ataaatgtta ctacaatgtt acaaaaacat 1281061 ttctaaatag atacagttcc aactgatgaa gagtaaatcg aaatggctac gaaagaagga 1281121 gtttttgttg ttggcaaaaa gaatcaaatg gtttcatgta ttaatagcag ttgtatgtgt 1281181 ggtgggcctt atcggctttt tccataatca ttcattgaaa aaagaaacgg tcatgaataa 1281241 agtaagaact gattctcaat atgggaatgt tgagatcgca acgcttgtga atgacgggaa 1281301 aacttttaat tacgcggtaa actatcctgt tttcaaaaat gaaaaaatgg attcggcatt 1281361 aaaaagattc gcagaaaaag aggttcgtca atttcaaaag gaaacaaagg acgttgacca 1281421 agagcatacg acaaaacgca acgaattaaa tgttgattat aaaattgtcc attatgccaa 1281481 acagacagtg gcgattgtat ttaatgaata taaatacatc ggcggggcac acgggcaaac 1281541 cgtgaaaaaa acgtttaact atgattttag taaacaagcg tttctttcca ttgatgatat 1281601 tttcaaagag gacgctgact acttacataa gctttcgtta atcgcttatc acgagctgaa 1281661 aaagaataag gacattgccg cggacgatgc actgttaaag gaagggacgg ctccgaaaaa 1281721 agaaaatttc agccgctttg ccatcaagga ggattatatc gaactttact ttgacacata 1281781 tcaggttgca gcaggctatc ttggagagca atcgattgcc attaagaaaa gtcttttgaa 1281841 agacattctg aaagaacaat atattgataa agcaaaaaat aaaaataaaa tcaaagaaca 1281901 aaagccgaag catgaagtga tttctttacc caaagaggaa acagttgatc caaatcaaaa 1281961 agtcattgcg cttactttcg acgacggccc gaatcctgcg acaacaaatc agattctaga 1282021 ctccttgaag aaatataagg gtcatgccac gttttttgtt ttggggagca gagttcaata 1282081 ttatccggaa acgctaataa gaatgctgaa agaaggaaat gaggttggga accattcatg 1282141 gagccatccg cttctcacaa ggctttcagt gaaagaagcg ttaaagcaga tcaatgatac 1282201 gcaagacatc attgaaaaaa taagcggata tcgtccgacg cttgtaagac ccccatacgg 1282261 cggcattaat gatgaactgc ggagtcaaat gaaaatggat gttgcgttat gggatgttga 1282321 cccggaagat tggaaagacc gtaacaaaaa aacaattgtt gaccgtgtca tgaatcaggc 1282381 gggagatgga agaaccattt tgattcacga tatttaccgc acctctgctg atgcggccga 1282441 tgaaattata aaaaagctca ccgatcaagg ctatcaattg gtgacagttt ctcagcttga 1282501 agaggttaaa aaacaaagag aagcgaaata aattagaaaa ggctgtccgt acggacagcc 1282561 ttttttctat ttaataagag cctgtggtgg cccaaacatt taagtttggt cctgaatact 1282621 tgccgaaagc gtaagaagtc cttggatcta aatcatatac catcggtgta tagcaagact 1282681 tttggccggc caccgctttt ccattgccgc ctgcagaatc acaattatat ctttttccgt 1282741 ctgtgttccg ggtaatctcc gcatttgctt catagccaga cgtcaatgta ttattcatcg 1282801 tgatttttgc ccaagccgtt ttacatgtac tgctgaattt aagctcgact actccgatga 1282861 cttgattgct ggcattcact aagtttgagg atttttttgt agagccgctg gacgcacaat 1282921 cattgtaata agggcttttt ccatcgtagg catgggtttc cgccttggcg ggtgcacctt 1282981 tgacggcaaa aacaaatact actgcgaata acaccaatga agccttcata aacagtcttt 1283041 tcaatttatg acctccttaa tatggcaaac aataaatcat atggaggaac aatcaaaaca 1283101 tgcatgcttt tttgtgaaca ataaaggcgg ccgggaggat ggagttcttg gccgcctctg 1283161 gtatgaggtt atgcttttac atcaatggtt tgtccgagag ttggatgttg aatcatcttt 1283221 aaggtttgat cggcattttg ctgggcggtg tccagccttt ttttcgttaa agcaatattt 1283281 acattctggg caagggatgc ttgatgcatc gcaaccgata aagcaggaat atccatggtt 1283341 ccacctccta tgccttacct atcggcgggt ttgtatgatt ttacagtgaa aaatggctta 1283401 atttctcttg ttgaccctta cgctgcggca tatcgtatgt ttttgacaag gagggaatca 1283461 ggatgaatct agtaatggaa aagacctttg agcaatacga aaagctgttt tcaatggaag 1283521 aacagaaaag agaagatgta tttcggtata cgatgatgag gccgtttgaa aagatgtgga 1283581 ccgccatcca agttccgctg aaagcgaagg agccaaacgg ctatgatgtg atcatggctg 1283641 cgaaaatgct gggctatttg gatgtccgtg atgctgaaag cggccagaaa gcactacaaa 1283701 tactgaaaga atcacatgtt tcagagacag ctgaatctgc acttcggcaa tgcatatttt 1283761 ttgctgagcg cgaacagctg cgggtgaatg caaaggagat caaattcggc ctttatatcg 1283821 ctgatccaaa taagcttcag ctgcaaaaag gctactgcgg gtttggcggg ataccgggct 1283881 ttattcatgt atggattaat ccgaacagtt ataacctgcc aaggattcct tccattattg 1283941 ctcatgagtt tcatcataat gtgcggtttt cgtatataga ttttcatcat ggctctgtaa 1284001 gtgtcgggga ttatcttgtg attgaaggat tggcggaatc attcgccaga gagctgtttg 1284061 gtacggaacg attgggccct tgggtaactc gttttgatca tgaagacttg caatattcca 1284121 ttgatgtgat taatgaggtg ctggatgtga aaggattttc ggaagtcagc cgttatatgt 1284181 ttggtgatcc aattgctaac gaccaaggct ttaagcctgc aggtttatcg gcttttgcgg 1284241 gttatgcagt tggctatcat gccgttcagt catttatgaa tcaacatcat atcacgataa 1284301 gcgaggccac acgtttggat gcgaagacca ttatttctca atgcggtctg ttttctacat 1284361 gaaaaaagcg tcacatacag cggcgctttt tgattcccaa aaccagcagt tctatggcgg 1284421 cacaggcggc aattccgatt gtatatgctt cgatatcgct ccataaaaaa ccgtacccta 1284481 gtacaagccc gccaagagaa gtatctctaa tctggtcgat ccattcggca tgatagagct 1284541 ggctgaattc aatgacaaaa cagaaagaaa gactgataat gcccgttatc attgtcttca 1284601 gcttccgaaa tagaaatccg catcccgtga agatcatggc ggcccacaac gagtctccca 1284661 gataagtatt gagggtatca ggaagaacac tggagaatgc tctggatcca agccccagcc 1284721 caatgatcag tatggtgaaa actgcatata tccaacgatt tcgcttcatt gcgaattgat 1284781 accccgtctc tgcttcatct ccctgtattg taaggaatat agcttttatt tgtccactaa 1284841 aaaagcggct gaatagccgc gtagggtgtt tattttgctt ttaggtttac atggtcggct 1284901 gtctgatccg tgcctattac aaaatggagt tcatagcggc ctgtatcata tacataatcg 1284961 atttcatcgg taaacgggac ggttaacacc cgatttactg gtcctaattg cttctgcagc 1285021 acttccggcg taactccgcc taaattcagc tgccgttcca caccggttcc aaagtagcgg 1285081 atttctgaaa ttgtcatgtc tttatgatag gaaaatccgt agcccggctg tcccatattc 1285141 cagtgatata aatcaaatcg attgtctccc ccgactggtc tttccggttc cccaaacgca 1285201 gcgtggacat ccccttttgt gcttttgtta atggtaaggc cttgcgcctg ctgaggcatt 1285261 tcccctttat aggcggtgtt atagaggttt ttgacaagct cagcggctga ttgattcgtg 1285321 ttttctgaga gtgtgtttgt ttgagctgcg gcctttgccg gtgctgaaaa ggacgcagcc 1285381 ccaaagccgg taaaacagct tgttactgct gctgccgcgg ttatagcaga cattgtcttt 1285441 ttcatgttaa tccctcctaa ttgatctacc attccgtttc cccgtgtttt tgcaacgaaa 1285501 catgtgagtg cgctttgtat gttttattga gttgttgtaa gggaactgaa ataggtaatt 1285561 cggtatataa agcaagaaag gggaatggag atggctggca agaaaacaat cacaataaac 1285621 ggcgttgaaa tggaagcgtc cgaggaacag acggtgctgc agcttttgaa taacagctcg 1285681 attgaagtgc cgcaagtttg ctatcatcca agcttagggc cgattgagac atgtgatacg 1285741 tgcatcgtca gcatcaatgg tgagctgaag aggtcgtgct ccgctgaatt aaaggatggg 1285801 gatgtcattg atacgctctc acctgacgtg aaaaaagcgc aggtcatcgg gatggacaag 1285861 attttatata atcatgagct ttattgtaca gtttgcgatt acaacaatgg gggatgcgaa 1285921 atacataata cggtgaagga aatgaaaatc aatcaccaaa gcattccgtt tgatcacaag 1285981 ccataccata aggatgaatc ccatccgttt tatcggtatg atccagatca atgtatattg 1286041 tgcggacgct gtgttgaggc atgccaagac gttcaggtaa ctgaaacgct gaccattgac 1286101 tgggagcgga aacgcccgcg cgtcatttgg gataacgacg tgccgatcaa tgagtcgtca 1286161 tgtgtgtcat gcggccattg ttcaacggtc tgtccgtgca acgcgatgat ggaaaaagga 1286221 atggaagggg aagccggata tttaacaggc atcaataacg aaacgctgcg accgatgatc 1286281 gagatcacga aaggcgtaga gacaggctac ggctcgattc tcgcgatttc tgatatggaa 1286341 tcggccatgc gtgatgaacg aatcaaaaaa acgaaaaccg tctgcacgta ttgcggcgtc 1286401 ggctgcagct ttgatgtctg gacaaagggc agagacattc tgaaagtaga gccgcaggag 1286461 gaagcgcctg ccaacggcat ttctacttgt gtgaaaggca agttcggctg ggatttcgtt 1286521 aacagcgaag aacgcctgac aaagccgctg atccgtgaag gcgatcattt ccgtgaagca 1286581 gagtgggagg aggcgttatt gctgatcgcc agcaagttca ctgaattaaa agaggcgttt 1286641 ggcccggatt ctctcgcttt tattacatct tctaaatgta caaatgaaga atcctatctt 1286701 atgcaaaagc tggccagagg ggtcattggc acaaataatg tggacaactg ctctcgctat 1286761 tgccaatctc ctgcgactgc cggcctgttc cggacagtcg gctatggcgg tgattcagga 1286821 tcaattacag atatcgcgca agcggacctt gttttgatta tcggttcgaa cacgtctgag 1286881 tcgcatccag tcttatccac tcggattaaa cgggctcata agctgagagg gcagaaagtg 1286941 atcgtcgcgg atatcagaaa gcacgaaatg gcagagcgct cagatttatt tgtccagccg 1287001 cgtgccggat cggatatcgt ctggctgaat gcgatcgcca aatatttaat agaaaacggc 1287061 aaggccgatg aacgattttt gagagaaaga gtgaacggac gggatgaata tgtaaaaagc 1287121 ctcgcgccgt acacacttga atatgctgag gagaaaaccg ggattgatca agaaaccctt 1287181 atccaaatgg cagagatgat cgggcaagct gacagtgtgt gcgcattgtg ggcgatgggc 1287241 gtgacacagc atattggagg aagcgacacg agcacggcga tctctaatct gctgcttgtg 1287301 acaggaaact acggaaaacc gggagcaggt tcttacccat tgcgcggcca taacaacgtg 1287361 cagggagcaa gtgactttgg gagtatgcct gacagactac cgggctatga aaaagtgacg 1287421 gacgaacaag tccgccaaaa atacgagcgt gtgtggggtg tgccgctgcc gaaggagccg 1287481 ggtatgacca accacgaaat gattgaaaaa atccattccg gacagttgaa agcgatgtat 1287541 gtaaaaggtg aagaaatggg ccttgtcgac tccaatatca atcatgtaca cgctgcatat 1287601 gaaaagcttg atttctttgt ggtgcaggac attttccttt cacgtacagc ggagtttgct 1287661 gatgtggttc ttcctgcgag cccgagcctt gaaaaagaag gaacgtttac aaacacagaa 1287721 cgccggattc agcgtttgta tcaggtattt gaaccgctgg gtgaatcaaa gccggattgg 1287781 cagattatta tggaggttgc caataagctt ggcgccggct ggctctatga gcatcctgca 1287841 gacattatgg aggaagcagc caagctgtcg ccgatttatg ccggtgtcac ctatgaacgt 1287901 cttgagggct ataattccct gcaatggcct gtaaacgctg atggaaagga ttcgccttta 1287961 ctctttacag agcgcttccc tttcccagac ggcaaggcca ttctctaccc tgtccagtgg 1288021 acagagccta aggaattcgg tgaggaatat gatatccatg tcaacaatgg gcggctcttg 1288081 gagcacttcc acgaagggaa cctgacttac aaatcaaaag ggatttcgga gaaaacaccg 1288141 gaagtgttct tagaaatttc tcctgagctt gcggcagaac gagggattca ggacggaacc 1288201 ctcgtcagac tcacatcgcc tttcggaaat gtcaaagtga agtgcctgat tactgatcga 1288261 gtcaaaggga aggaagtata tctgccaatg aacgattcag gggaagcggc gatcaacctg 1288321 ttaacaggca gccatgccga taaggatacc gatacgcctg cttacaaaga aacatcggcc 1288381 aagatggaaa ttttgaagca cgacggaatc agcccgctgc ctaagatcaa ccaccgcaac 1288441 ggcaatccgc agccgcaaat cggtgtgcag gttcataaga aatgggcgcg gaaggattat 1288501 attttccctg gtgacgctgt gaaaaggggg atgggccata atggctaaag cgattaaacg 1288561 aatccaaaaa atcgaggtaa cagaagagga tcagcgaaag cgtgatttgc gggaaattga 1288621 agatgctcta attgaccaca aagaagcgat tctcgaaaca ttgcatatgc tgggccatat 1288681 gaacgagcgc ggggtcctgc cgttgctccg cggccttttt ggtcaagggg ataaagttct 1288741 tgatatcctg gtgaaaaagg cagatacaga ggaaacagcc aatacgctga aaaatctgct 1288801 tcttctgttt ggaacactcg gcatgctgga cgtgaagcag ctggagcctc tcattttgaa 1288861 agtgaatgcg ggtgtggcaa gcgctgtaga gcagaaaaac agtgaagaaa agacaggtta 1288921 ttttgatatt atccgctcgc taaaagaccc ggaaatcaac aaatcaatta cactgctctt 1288981 ttccttttta aaaggaatgg gacaagatac aaaggagctg gaacgcacga cgcagcctcc 1289041 ggaacaccaa aaacatcatc aggaaccccg agagaaaaga ggaatgaata agcgagattg 1289101 acctcccacc cgagcggctt cagccagctc gggttttttg atgaaaaggt ctaatggact 1289161 agtaaaaaat attcaaatac taggaagaag taagattgtg atgaatgaga tagaaataat 1289221 cgttactttc ttacctgtta agaaaaggga aaatctgatt ataatagaaa tcgattactt 1289281 tagatggggg aacaatcatg aaaaaagtct tattactatt atttgtcttg acgatcgggt 1289341 tagcgctttc tgcgtgcagc caatcgagcg atgcgtcaga gaaggaaaaa ccgaaagaga 1289401 aaaaatcgca agaagagctt gaaaaggaac ttgataagga attgaaaaaa ggcggtgagc 1289461 cgaagaccaa aaaagatgat caaatacata aaataggaga aacatttaaa gcaggacata 1289521 cgaattttac agtgaataaa gttgatagag tgcaaaaagg tgaatatatg aatgttggcg 1289581 gagctgtaaa tgaggagaca aaaacaataa aagatgatga ggaacggctt attatagaag 1289641 ttacgatgga aaatataggg gaagattcaa taagctacaa ttttatcggg tttgatttaa 1289701 gagataagaa tgatcaatca gtgcggcctg ttttttctat agaagagaag ggcagaatcc 1289761 ttatgggagg aacactagta tcggggaaaa aggttacagg tgtactcagt tatgtcatcc 1289821 ctaaaggaga acagaaacat tacacactgg tatataatcc gtttttagct gatacaaata 1289881 gcagtaatac agaagagaga gtaaaggacg atattgatta cttggtgaag ttagattaga 1289941 tgctaattta cagttgcacg tttttcatct gtggaaaacg tgcatttttt atagcgaaac 1290001 ttgacttgaa aggatgagtg ataaaagtgc aaaccaaatg gctggaacgg gcacagcgga 1290061 ttcgggcgat cgcccaagcg gggcttgctt tttccaagga tgtgtacgac agggagaggt 1290121 acgaagagct aatgaagctt agcgcggaaa tgatggcgga ttactcggag aaggacattg 1290181 aagttatcac tgatttatgg caaggcgaga agggctatcc aacaccgaaa gcggatgttc 1290241 gcggcgctgt attcagagag aatcagattt tgcttgtccg ggagaagcat gatgagctgt 1290301 ggtcgctgcc gggcggattt tgcgagattg gtttatcgcc ggctgaaaac gttgtcaagg 1290361 aaatcaaaga agagtcgggg tacgatacag agccgtctcg attgctggcc gtgctagaca 1290421 gccataaaca ctctcatccc cctcagcctt atcactatta taaaatcttc atcgcatgca 1290481 gcatgacgga cgggcagggg gaaacaggga tcgagacgaa tcatgccgct ttttttccgg 1290541 aagacagact cccgccgctt tctcctaaac gaaacacacc ctcacagctt agcatgctgt 1290601 ttgacttttt gcgccatccg gacaagaaaa cgatatttga ctaaaaaaga aagagcctgt 1290661 gggctctttc ttttttataa tgtaatgtgt ttttcgttgg cgagtttcag aagggtcaaa 1290721 atagaatcgg cttgtttatg gccgagtttt tgctttaatt tgttttcttc aactaatcgg 1290781 ctgccataaa ttttgacgga ggctttgtcg acgacagtat gccagttttc ctgttttttt 1290841 ccctcaacaa gcggtttttc atgtctctca gaaaaagaga acacaaagag tacgaatgca 1290901 agtgaaagta ggattccgac aacttgtttt ttgtaatcag tctgtgctgc cacgttgttc 1290961 tctccttcac cttttacctt ctatttaatc atagaaccaa attattttac ataatgggaa 1291021 agtcattttt ggagttagtg catttggttg aaaacagaga cgttttttga gcggagcggt 1291081 gcaattgaat ccatattgga tttgcgtgct tatgcctaag gtcacgttgt gagccaaaac 1291141 agcagtgcag aatagaaaaa aattgaaaga ttatggtaag atgaacgaaa ttcgaggggg 1291201 aatatatgat gcctgcatcg aacatcgtga tcgcctgcct gctgttatca atttaattat 1291261 ttgtggtagt ccctctcttt ttcgaaagcg ggaggtgaag tggaacatta attgctgaat 1291321 tctttcaagg ggagtgaccg tacatgaatg tgttaaaccg ccggcaagcc ttgcagcgag 1291381 cgctgctcaa tgggaaaaac aaacaggatg cgtatcatcc gtttccatgg tatgaatcga 1291441 tgagaaagga tgcgcctgtt tcctttgatg aagaaaacca agtgtggagc gtttttcttt 1291501 atgatgatgt caaaaaagtt gttggggata aagagttgtt ttccagttgc atgccgcagc 1291561 agacaagctc tattggaaat tccatcatta acatggaccc gccgaagcat acaaaaatcc 1291621 gttcagtcgt gaacaaagcc tttactccgc gcgtgatgaa gcaatgggaa ccgagaattc 1291681 aagaaatcac agatgaactg attcaaaaat ttcaggggcg cagtgagttt gaccttgttc 1291741 acgatttttc atacccgctt ccggttattg tgatatctga gctgctggga gtgccttcag 1291801 cgcatatgga acagtttaaa gcatggtctg atcttctggt cagtacaccg aaggataaaa 1291861 gtgaagaagc tgaaaaagcc tttttggaag aacgagataa gtgtgaggaa gaactggccg 1291921 cgttttttgc cggcatcata gaagaaaagc gaaacaaacc ggaacaggat attatttcta 1291981 ttttagtgga agcggaagaa acaggcgaga agctgtccgg tgaagagctg attccgtttt 1292041 gcacgctgct gctggtggcc ggaaatgaaa ccactacaaa cctgatttca aatgcgatgt 1292101 acagcatatt agaaacgcca ggcgtttacg aggaactgcg cagccatcct gaactgatgc 1292161 ctcaggcagt ggaggaagcc ttgcgtttca gagcgccggc cccggttttg aggcgcattg 1292221 ccaagcggga tacggagatc ggggggcacc tgattaaaga aggtgatatg gttttggcgt 1292281 ttgtggcatc ggcaaatcgt gatgaagcaa agtttgacag accgcacatg tttgatatcc 1292341 gccgccatcc caatccgcat attgcgtttg gccacggcat ccatttttgc cttggggccc 1292401 cgcttgcccg tcttgaagca aatatcgcgt taacgtcttt gatttctgct tttcctcata 1292461 tggagtgcgt cagtatcact ccgattgaaa acagtgtgat atacggatta aagagcttcc 1292521 gtgtgaaaat gtaatagata aggagactgg agattcatga aaaagtacca tatttcgatg 1292581 atcaatatcc cggcgtacgg acatgtcaat cctacgcttg ctttagtaga gaagctttgt 1292641 gagaaagggc accgtgtcac gtacgcgacg actgaggagt ttgcgcccgc tgttcagcaa 1292701 gccggtggag aagcattgat ctatcataca tccttgaata ttgatcctaa gcaaatcagg 1292761 gagatgatgg aaaagaatga cgcgcccctc agccttttga aagaatcact cagcattctg 1292821 ccgcagcttg aggagttata taaggatgat cagcctgatc tgatcatcta tgactttgtt 1292881 gcgctggctg gtaaattgtt tgctgaaaag cttaatgttc cggtcattaa gctctgttcg 1292941 tcatatgccc aaaatgaatc ctttcagtta ggaaatgaag acatgctgaa aaaaataaga 1293001 gaagcagagg ctgaatttaa agcctacttg gagcaagaga agttgccggc tgtttcattt 1293061 gaacagttag ctgtgccgga agcattaaat attgtcttta tgccgaagtc ttttcagatt 1293121 cagcatgaga cgttcgatga ccgtttctgt tttgtcggcc cctctctcgg agaacggaag 1293181 gaaaaagaaa gcctgttgat tgacaaggat gatcgcccgc ttatgctgat ttctttgggt 1293241 acggcgttta acgcatggcc ggaattttac aagatgtgca tcaaggcatt tcgggattct 1293301 tcatggcaag tgatcatgtc ggttgggaaa acgattgatc cagaaagctt ggaggatatt 1293361 cctgctaact ttaccattcg ccaaagtgtg ccgcagcttg aggtgttaga gaaagctgat 1293421 ttgttcatct ctcatggcgg gatgaacagt acgatggaag cgatgaacgc aggtgtgccg 1293481 cttgtcgtca ttccgcaaat gtatgagcag gagctcactg caaatcgggt tgatgaatta 1293541 ggccttggcg tttatttgcc gaaagaggaa gtgactgttt ccagcctgca ggaagcggtt 1293601 caggctgtat ccagtgatca agagctgctc agccgcgtca agaatatgca aaaggatgta 1293661 aaagaagctg gcggagcgga gcgtgcggca gctgagattg aagcgtttat gaaaaaatcc 1293721 gctgtcccgc agtaaaaaca taaaaaccga aatcaatttg atttcggttt tctgtttaaa 1293781 tatttttttt catcccgcat ctccggcatt ctctaagaaa ttttccgcct tttacagagc 1293841 ttttgaacag tgtgtaatca cagttgtcgc agcgcccgct gcgggcatcc ggatattcat 1293901 tgaattcgta aacaatcgat gtatcgtagc cttttgtttc atattcttct tttttggttt 1293961 ccatgtcgat cctccgttac aagacgtgtc tgctgtttat cttacagcaa gcttccggcg 1294021 tattcaatgg attttaggag gttgggttta tcttgatttc tcccttggtt tgcgccaaaa 1294081 tagctttatt aagcttatat acataaaaag cctatgcaaa gaggagagga aacgggtatg 1294141 ggaaaagggt tacttggaaa acgcgtggca atcggtggct cacgaaaaac ggaagaaatt 1294201 agtacaatca ttgaaaaaca gggcggaata cctgtcatcc ggcctctcca aggtacagtt 1294261 tacttagcag agaagcaggt ggagccggat ttgcggacgt ttgcggaaga aaaagctgac 1294321 tgggtcattt tcacgacagg catcgggttg gagactcttg tcgatatggc agagaaaatt 1294381 ggactgaaag atgagtttct gcaggccatt cgccaagcga aagcggcatg ccggggatac 1294441 aaaacgctgt ctgcgctgaa aaagcttgga atcacaccgg aagcttcgga tgaagacggg 1294501 acaacaagag gcttaatccg ttccttggag cctcacgact tttcaggaaa aacagtcatg 1294561 gtgcagcttc atggcgaaaa agcgccggct ctcatggcat ttcttgaaga aaaaggcgcg 1294621 tctgtcctgc cgattctgcc ttatcagcac atcccgccgg aggaggaaac ggtggagcgg 1294681 ttatgccgag agctgatgaa cgatgaggtc gatgccgttt gttttacaac ggccattcag 1294741 gttcgttccc tgtttgattt tgccaagggg cgaggttata tcaatgaagt gaagaaggta 1294801 ttcgaagaac gcgccatcgc agctgctgtc ggaaaagtga ctgctgaagc actgcgggaa 1294861 gagggcatta cgagactgct tgcgccagag attgagcgga tgggtgcgat gattgttgag 1294921 ctggccaagt attatgaaga aaaggaataa caagtacaaa aagccgcttt tccctcggaa 1294981 agcggctttt gtctgtcatt cattttgctt cagctgctga tgaacggtga ataatgatgg 1295041 gtatgtcagc acgcttaaga ttacacaagt cagcgcggct gaggccatcg ttgtaaacac 1295101 gattaagagt tgaaagcgta ctgcctgaat cgggtccgcg ccggctagaa tctggccagt 1295161 catcatgccg ggaagctgga caagacccag tgttttctgg ctttcgagcg tcgggatcat 1295221 actcattttc atcgctgagg taagaatgcg ctgtatggat tgcttcggtg tgccgccaag 1295281 tgacaatatt aattgaattt cttctttgcg aacgccgact tctgagttaa gccggtttag 1295341 aaacaaactt gagagcacca tcgaatttcc gatgaccatc ccgctgatcg gaatgacata 1295401 tcgtgccgta agcggaatga tatgaagaga cagcagaatt ccctgcgtca caatttctac 1295461 gattgctaac gcggcaaaca ccctccaaaa cgaaccgata gtatttttct ttcgcttgat 1295521 gacattttgc gccgccaccg cgagcattaa cagcaccatc agcaggataa aaacagggtg 1295581 gtctccgcga aaaatcagcg acaaaacata accgatgata agcagctgca ccgcggcccg 1295641 gatggtggcg atgatcatgt ctttttctac accggcttta aaggattttg ataaaaacaa 1295701 ggcgatcaaa acaaagatca tcgttaaaga gagagaaagg taatccatta ccgagtgcct 1295761 cccttcaaaa attctttcgc tgcttcatgc tgcggagcgg agaaaaatgt gtcggtttca 1295821 gcgatttcaa gcagccggcc atctgccata aaccaaatgg tatcggctat tcgttttgcc 1295881 tgctccatat tatgagtgac ccacatgact gtccattttt tctcttgatg ctgacgtttg 1295941 atcagttctt caatctcaag agcagagacc gggtccaagg ccgatgtgat ttcgtccaac 1296001 aatagaatgg aggaaggatt tgagagcgtt ctggccagtg acagtctttg ccgctgcccg 1296061 cccgataagt ctctggcgct tctgtctaac aactctggcg gcagccctgc aagcgaagcc 1296121 agcttttcag gagagtacag ctgggattga tgcagccttt gtacaagact taaattgtca 1296181 cgcactgtcc cgtcgagcac gggagccgat tgaaacgcga gggctgccgt tcgcctcagc 1296241 tcattgacat tccattctct gacttccttt ccgtatatgt tgacttcgcc gctgtcaggc 1296301 gttctcatta aattacacat agaaaggagg gtgcttttgc ctgagccgga agggcctaaa 1296361 acggctacga ttgcaccctg ttgaatgtct ccggtgacat cctgcagcac atcataggtt 1296421 tgtccatctt gtttatagct ttttctgact gatctgaagg agatggctgg tatgttttgt 1296481 gtttgatcgt ttgcttccat tacaataatc acctttcaat ataagtaggc tgacattata 1296541 tttaactata acgtgaaaca gattcctttt ggtagcacaa ataaaggaga acaggctttc 1296601 acccattctc ctgcagatgc tacgcagtca gatttgactg tgctttcttt ttcggttttc 1296661 tcggctgtga agcgaaggta tgtaacatca tccccgctat tataatgaac aaaccggcaa 1296721 atgataatag agatgggaaa acgcctgaca gcagaacaat ttcaccaagc agcgcgaaaa 1296781 tcacttcacc ggattgagtg gcttcaacag ctgcgagttt ttgcggattg tctcttacca 1296841 tatcagtggc ccagaaaaat aaaaccgtcg caatgatgcc tgagctgacg gcaacgataa 1296901 aggattgaac ggtttgactt gctgttggaa ggccatctga ccaccagccg taagctgcta 1296961 atataagcca gaatggaagg cttgccaatg tcattccaag cacgcgctga aatgtatcaa 1297021 gccggcctcc gtattcttcg agcattcttc ggtttcctaa cggataggca aaagccgcaa 1297081 tgacaaccgg cagcacactg aaaagcagca tcctcccaga aagcgattct gcatgctgaa 1297141 gctgaatcag agccgctcca atcaggatga tcacagaagt gccaagtgaa accaggggaa 1297201 tcttttggcg aatgagctgc ggaccgcccg gcatatcttg tttgacataa aacaaaggag 1297261 ataagagcac cccggctaca attgtaattt gccaggttcc agctatgagc caccccggac 1297321 cgtatgcagc cgcaaatgta atcggtgcgt aaaaaagcac gaaaccgacg aagctccatt 1297381 tgatccaata aaacggcttt ttcctcattt ctagtaagag aggcgtgaat gtccctctca 1297441 tgatgacaat caaacataaa aatggcacca taaaaataaa gcgcagcgaa gagctccaaa 1297501 gccagctgcc tcctgataac tccatcgctc tgtttaatat aaaggtaacg gcgaaaaaga 1297561 gtgaagccaa tattccgata acgatagctt tcatgatatc cctcattctg gcattatttt 1297621 tttatactat actattcggt atcatgcaga tcaatggaat catgagaaaa acatcatgtt 1297681 tggcgaaccg ctatatgtgg aagacaaaaa agggaggtga aattgatgga aagagagaca 1297741 cagacatact tctttccgga tgacggcagg attccgaatc accctgattt tccgctcgtg 1297801 gtgtatcaaa acgcgcttaa ggacaccgga ctggcagagc ggatcgtcac ccggcatggc 1297861 tggtcaaaca gctggtcagg gagtgttttt ccataccatc attatcacag caatacgcat 1297921 gaagtcctga ttgcccttag gagagaggct gtgattcagt ttgggggaga aaaaggggct 1297981 gccatccctt tcaaatcagg cgacgcagtc gtgattccag ccggagtcgg acataaaaag 1298041 ctcagctcaa gccccgattt tactgtcctt ggcgcctatc ccggtggcgt tcagtacgat 1298101 atgaagacgg ggaagccgaa tgagcgggag gaagcggtca aacagattaa gcaggcggcg 1298161 ttgccggcga atgatccgat cacaggaaaa agagagcctc tattggaaat atgggtaaag 1298221 tgaaggggag aaattgctgg attgtcaata actagtgccg cagaaacgat atgacatgag 1298281 ctccatataa attaatttca taatcgaagc aattcacgtt caaattttgt tcaaaaagtg 1298341 ttatcatata gaaggtaatc gaattggagt tttttgtgtt tgctattttc agagagagta 1298401 aaggattttg acttattcaa ttgtttattt ttagataaaa ataatactga atatggcaag 1298461 atgaaaaact gggtagtaaa catttatttt tgtaaatgat tgtgcatgaa ttcacaatcc 1298521 ttattcttat gccttaaaag cgtgagacag ggagaggcac taccctttcc aaaaaaatca 1298581 gcaaactgct tatagtaaag gagaattgga tatgccagaa acaatcgatc aaacaaatgc 1298641 gtctgtcagc caaagccagc aagatcttat tgatcagcta ttaaagccag aagttcaaga 1298701 atcattgact gttttagttg accagcttcc gaagctgact gagttagtga atattttaac 1298761 gaagtcttat gatttcgctc agtctgtagc gactgacgaa gtgttaaaga gcgacacagt 1298821 cggtgcgatc actgaaattc tcgagcctgt aaaagaaaca gcgaaagaag tagctgcgac 1298881 tgcgatcgaa gcaaaagacc gcgcggaagc aagcaacgaa acaattggac ttttcggcct 1298941 tcttcgcatg ctgaaagatc ctcaagctca aaagctgttc cgttttgcta acagctacct 1299001 tgaagtcatg aacgaacgcg aaaaccaaaa ataatctcag attcaaattg atataaagga 1299061 cggaggatat acgatgtcaa aacatattgt cattctaggc gctggttatg gcggagttct 1299121 ttctgctcta acagttcgca aacattacac aaaagaacaa gcacgcgtga cagtggtaaa 1299181 caaataccca actcaccaaa tcattacgga attacaccgc cttgctgcag gcaacgtgtc 1299241 tgaaaaagcg gttgcaatgc cattagaaaa acttttcaaa ggcaaagaca ttgatcttaa 1299301 aattgcggaa gtaagctctt tctctgttga taaaaaagaa gttgcgcttg ctgacggttc 1299361 tacattaact tacgatgcgc ttgttgtagg tcttggttct gtaacggctt acttcggcat 1299421 cccaggtctt gaagaaaaca gcatggtatt gaaatctgct gccgatgcga acaaagtctt 1299481 ccaacatgtt gaagatcgtg tgcgcgagta ctctaaaacg aaaaacgaag cagatgcaac 1299541 aatccttatc ggcggaggcg gcttaacagg tgttgagctt gttggtgagc ttgctgacat 1299601 catgccgaac cttgcgaaaa aatacggcgt agaccataaa gaaatcaaat tgaaacttgt 1299661 tgaagcaggt ccgaagatcc ttcctgttct tccggatgat cttatcgagc gtgcgactgc 1299721 aagccttgaa aaacgcggcg ttgagttctt aacaggtctt cctgttacaa atgtagaagg 1299781 aaacgtaatc gatctgaaag acggatctaa agttgttgcc aacacatttg tttggactgg 1299841 cggcgtacaa ggtaacccat tagtcggtga atcaggccta gaagtgaacc gcggacgcgc 1299901 gactgtaaat gacttcctgc aatctacatc tcatgaagat gtattcgttg ctggagacag 1299961 cgcagtttac ttcggtccag acggccgtcc atacccgcca actgcacaaa tcgcatggca 1300021 aatgggtgag ctgatcggtt acaacctatt cgcttaccta gaaggcaaaa cgcttgaaac 1300081 attcaagcca gtaaactctg gtacacttgc aagccttgga cgcaaagacg cggttgccat 1300141 cattggtgct aattctacac cgcttaaagg tcttcctgct tccttgatga aagaagcaag 1300201 taatgtacga tatttgacac atattaaagg acttttcagc ctggcttact aatcctttta 1300261 atgaatctgg cattgccaaa agcattcctt tccgagtgct ttctggcaat gtcttttttt 1300321 atgtttatga cagcgttaac atttcatttt caaaaaagag attgatccca aaggaatata 1300381 aaggtaaaat aaaaacaaat caaaatgtta acgttaacat tttgaaatag aatgaaagac 1300441 ggtgaggaca tggaaccctt catgggcaaa aactttttat tgaaaaatga aaccgctgtc 1300501 agcctctatc acaattatgc gaaagacatg ccaattattg attaccactg ccacttaagt 1300561 ccgaaagaaa tctatgaaaa taagacattt caaaacatca cggaagcctg gctgtatggt 1300621 gaccattata aatggcgcat catgagagcc aatggaattg aggagacata cattaccgga 1300681 gatgcgcctg atgaggagaa atttatggct tgggcgaaaa ccgtgccgat ggcgattggc 1300741 aacccgctct acaactggac tcacttagaa ttgcagcgtt tttttggcat ttacgagatt 1300801 ttaaacgaga agtccgggtc ggctatatgg aaacagacaa ataaactgct caaaggggaa 1300861 ggcttcgggg caagggattt aatcgtgaaa tcaaatgtaa aggtcgtgtg caccacagat 1300921 gaccctgttg attctcttga ataccattta ttgttaaaag aagacaaaga ctttcctgtc 1300981 agtgtgctgc ctggatttcg gccggataaa ggacttgaga tcaatcgtga aggctttcct 1301041 gagtgggtgc aggcgcttga agatgccgct gccatatcga ttacaaccta tgatgagttt 1301101 ttaaaggcgt tggaaaaacg agtgcgattc ttccactcag ccggcggcag agtttctgat 1301161 cacgcgatag atacaatggt atttgccgaa acaacaaaag aagaagctgg acggattttt 1301221 tctgacagat tacaaggaac agaggtttct tgtgaagatg agaagaaatt taagacatat 1301281 acgcttcagt ttctttgcgg tttgtatgcg gagctcgatt gggcgatgca gtttcatatc 1301341 aacgctttaa gaaacacgaa tacaaaaatg atgaaaaggc tcggacctga tacagggtat 1301401 gattcaatga acgatgaaga aattgctaag cctttataca agctgctgaa ctcagttgag 1301461 atgaagaacc agctgccgaa aacgatttta tattcactga atccaaatga taactatgtc 1301521 atcgccagca tgatcaacag ttttcaggac ggtattaccc cgggaaaaat acaattcggc 1301581 acagcctggt ggtttaacga tactaaagac ggaatgctcg accaaatgaa agcgttatca 1301641 aatgttggcc ttttcagccg ttttatcggc atgctcaccg attccagaag ctttctttcg 1301701 tatacgcgcc acgaatattt caggcggatc gtctgcaatt tgattggaga atgggtggaa 1301761 aacggcgaag tgccgcgcga tatggagctt ctgggaagca tcgttcaggg gatttgctat 1301821 gacaatgcga aacactactt tcaatttcaa gaagagaaag caaacgtgta acaaagtgtc 1301881 cgctcagtat cgctgagcgg atcactatcc gaaaattctt aagacacaga ggtggaacat 1301941 gcgaactgaa ctggcaaata aggttgtgtc ggtcgaaacg gaaaaaaggc tttcattgaa 1302001 agagaaaatg tcctatggct ttggtgattt tggcaacggt tttatgtttg atctcggcca 1302061 gatttattta ttgaagtatt tcactgatgt agcgggaatc cccgctgcga tggccggcgg 1302121 cattttttta gtcagtaagc tgtttgcagc gataacagat ccaattgtcg gctcatcaat 1302181 cgattatcgc aaaaacatcg gcaaacgggg gaaattcagg ccttatctat taatcggcag 1302241 catcgtgctt gcggtgctta ctgttcttat ttttctgtct cccaatgtat caacgaccgg 1302301 aaaactgata tatgcatatg catcctatat gatttggggc atcggctatt cgtttgtgaa 1302361 tattccgtac ggctcattag gggcagcgat gactcaaaat tctgaggacc ggacctccat 1302421 ttcgacgttc cgccaaatcg gatcacttgg cgccttgttt atcacaagtg tggccgtgat 1302481 gccgctgctc gtcaagtttg ataatccgaa ggtcggctac ccggtggtca tgggcttgtt 1302541 cgccgcgctc ggtgtgtttt ggttttatat ttgctaccgc aactgcaaag agcgcattat 1302601 catatcggaa gcacccaaag aaaaattaac actctcatct gtcgtcaaaa catttattac 1302661 aaataaaccg ctgttaaccc ttgtcctgat gacgattttt tcaatttccg catacaacat 1302721 taaatccgcc atgctcgtct atttcgcaca atataacttg ggcaatgttg aattaatggc 1302781 ttatatgaac ttcatcatta ttggttcttc ctttttgggc gtcgtattcc ttccaaagct 1302841 cgtcaagatg tttggaaaga aacgaacggc aatgatcggc tttggcatca gtgtggccgc 1302901 ggatctgatc aactttatgc ttccatctaa cgtttatgtg tttacaattc tcgccagtat 1302961 cgcctttatc ggaatcagta tcccaaatgg catcacgtgg gctcttgtct ccgatattat 1303021 cgactatggc gaatggaaat ccggtgaacg gaaggaagca acgacatatt cacttttcaa 1303081 tttctcaaga aagcttgctc aatctttgtc tggctttctc tcggggatcg gtttggggat 1303141 tatcggctat gtgccgaatg cagtccagac agcacaggcg ctgattggca tcaaagcgct 1303201 gcttcttctg tatccggcca ttgctttggc attagcgatg ttcattatcg gctttcttta 1303261 taaactcaca gaccagcagc atgctcagat cgttcaggat cttcatcaaa agagctgaca 1303321 atataatata aagaatattt aaaataattt gtaaataaaa tgtgtttgta ggggtttcgc 1303381 ttggagagtg cccaaaaaac tgaaaaggaa ggaggcactt gcttgaaaac gataacaatt 1303441 gcagctgaag aagcaaagga actcgtttgg caaaagctgg acggtgccgg tttgaatgaa 1303501 cgagatgctg aaaaagtggc agatgttctc gtgcacgctg atttgcgcaa tgtacattcg 1303561 catggcgtgc tgcacacaga acactatgtg aacaggcttt tagcgggagg gatcaatcct 1303621 ggggcacagc ctgtttttaa agagacgggg cctgtgaccg gggtgcttga cggagacgat 1303681 ggtttcggtc atgtgaattg cgacatggcg atggaccatg caattgacat ggcgaagaaa 1303741 aaaggagtcg gcatggtcac ggccgtaaac agcagccatt gcggagcgct aagctatttt 1303801 gtgcaaaaag cggctgacga aaagctgatc ggaatggcaa tgacgcatac agacagtatc 1303861 gttgtcccat ttggggggag gactcctatt ttagggacaa atccgattgc ttacggagtt 1303921 ccggctaagc ataaaaaacc gtttatccta gatatggcga catccaaagt ggcttttggg 1303981 aagattctgc aggcccgtga agagggcaaa gaaattcctg aaggatgggg agtcgatgaa 1304041 aacggagaag cagtaactga tcctgacaag gtcgtctcac tttcaacatt cgggggcccg 1304101 aaaggctatg gactatcgat tgtagtggat gtgttttccg gattgctggc gggcgcggct 1304161 tttggccctc atattgccaa aatgtacaac ggccttgatc aaaaaagaaa gctggggcat 1304221 tacgtttgcg cgatcaatcc atcctttttt actgactggg atacgttttt agagcagatg 1304281 gatgccatga ttgatgaact gcagcaatca ccgccggctg ttggattcga aagagtgtat 1304341 gtgcccggcg agatcgagca gctgcatgaa gaaagaaata agaaaaacgg aatttctatc 1304401 gcccggagcg tgtatgaatt cttaaaaagc aggtgagtaa aatgaaagcg gttcaagtgc 1304461 gaaaagcgta tgatctggtg acagcggagg tgaagaagcc agttctttca aaggatgatg 1304521 aagtgctcgt gaaagtcaag cgagtcggca tttgcggttc agacatgcac atttatcatg 1304581 gaacgaatcc gctcgctacc ctcccgagag tcatcggaca cgaggtaacg ggacaagtgg 1304641 aggcagttgg tgcgaatgta cagagcctaa aacccggtga tcatgtggtg attgagccga 1304701 tttcttattg cggatcgtgc tatgcctgcc gcaaagggcg gccgaatgtt tgcgccaagc 1304761 tttctgtatt tggcgtacat gaggacggag gcatgcggga atatattgtg cttccggaaa 1304821 gacagcttca cgcggtctca aaggacttgc cttgggagga agcagtcatg gccgagcctt 1304881 atacgatagg cgcccaggca gtgtggagag gccaggtgga aaaaggtgat accgtcctga 1304941 tccagggagc ggggcccatc gggatctgtg tgttaaaaat ggcaaaactg gcgggcgctg 1305001 ctgtcatgat gactgacttg aacaacgagc ggctggcatt tgcgaaagaa aacggcgccg 1305061 atgctgttgt aaatgtccaa gcagaacatg ttgccgagcg ggtccttgaa tggactggga 1305121 atgaaggagc aaacgtggtc attgatgctg tttgcctgcc ggagactttt gcactttcaa 1305181 ttgaggctgt gtcaccggcg ggacatgtgg ttgtgcttgg atttgatgaa agagcggctc 1305241 agatttctca gctgccaatt acaaaaaaag aagtcacgat aaccggatcc cgattgcaga 1305301 ccaatcagtt tccaaaagtg gtagagcttt tgaatggagg ccggttaatg cataacgggc 1305361 tggtgaccca tacattttca gttgatgacg ttcatcatgc atttcagttt attaaggagc 1305421 atccagatca ggtgcggaaa gccgtcatca cgtttgatta aatgactgaa tccggaggtg 1305481 cgagcatgaa tatgacattc cgatggtatg gacgaggcaa cgatacagtc acacttgaat 1305541 acgtgaagca aattcccggt gtcaaaggca tcgtttgggc tctccatcaa aagcccgtcg 1305601 gcgacgtgtg ggaaaaagaa gaaatcagag ccgaaactga atatattcaa tcctatggtt 1305661 ttcatgctga agttgtagaa agcgtgaatg ttcacgaagc gattaaactt gggaacgaag 1305721 aacgcggccg gtatattgaa aactacaagc aaacgatccg caaccttgcc ggatttggcg 1305781 tgaaagtgat ctgctataat tttatgccgg tttttgattg gacacgcacg gacatgttcc 1305841 ggccgctaga agatggatcg accgctctgt tttttgaaaa ggccaaggtg gaaagccttg 1305901 atcctcaaga gctgattcgg acggtggagg aagcatccga catgacactg ccggggtggg 1305961 agcccgaaaa attggctcgg atcaaagagc tttttgctgc ctacagaacg gtcgatgaag 1306021 aaaagctatg ggacaattta tcattctttt tgcaggaaat tcttcctgtt gctgaggcct 1306081 atggtgttca aatggccatt catccggatg acccgccgtg gccgattttc ggactgccgc 1306141 gcattatcac aggagaggca agctataaga aactgcgggc gatatcagat tcaccgtcta 1306201 attgtatcac cctttgtaca ggttcaatgg gagccaatcc cgctaacgac atggtggaga 1306261 tcgctaaaac gtatgccggc atcgctccat tttcacatat tcgcaatgtg aaaatttatg 1306321 agaatggcga ttttattgaa acatctcatt taacaaagga tggttcgatc aacattcaag 1306381 gcgtgatgga agaactgcat aagcaggatt acgaaggata tgtcagaccg gatcatgggc 1306441 gccatctttg gggcgagcaa tgccgcccgg gatatggctt atacgatcgg gcacttggca 1306501 tcatgtattt gaacgggctg tgggacgctt atgaagcaat ggcaaaaaaa gaggtgggca 1306561 tatgatcccg ctgcatgaga acctggctgg taaaacggct gtcatcactg gcggcagcgg 1306621 cgtgctttgc tctgcgatgg cccgggagct agcccgtcat ggcatgaagg tggcgatttt 1306681 gaatcggacg gctgaaaaag gccaagcggt cgtgaaggag ataacggcgg ctggcggcac 1306741 agcgtgcgct gttgctgcgg atgtgctgga caggatgtca ctggagcggg caaaggaaga 1306801 catccttggc caatttggcg ctgttgatct gttaattaac ggggctggcg gcaatcatcc 1306861 tgacgcgata accgatgtgg agacatatga agaagcggga gaaggccaat ccttttttga 1306921 tatggatgag aggggctttc taactgtatt ctccaccaac ttcaccggtg cgtttctggc 1306981 ctcgcaagtg tttggtaaag aactgctgaa ggcggattca cccgcgatca tcaacctttc 1307041 ttccatgagt gcttattcac ctatgacgaa ggttccggca tacagtgctg cgaaagcatc 1307101 catcaataat tttacgatgt ggatggctgt tcattttgcc gaaaccgggc tgcgggtcaa 1307161 tgcgattgcc ccaggcttct ttctgacaaa acaaaatcat gatctgctga tcaaccaaga 1307221 cggaacgttc accagccgat ctcacaaaat tattgcggga acaccgatga agcgcttcgg 1307281 aaaaccggag gatttgctcg gtacgctcct ttggctggcg gatgaatcct attccggttt 1307341 tgtcactggg atcaccgttc ctgtcgatgg aggatttatg gcttattcag gtgtgtaacg 1307401 aaagcggtgc aacagaaact gaaccaacat aggggtgagg ttgagatgtt ttcaaaagat 1307461 aagcttcccg ttatcctttt tttgttcctg gcaggggtga ttaattacct ggatcgctcg 1307521 gcgctttcca ttgcagctcc ttttattcag gatgatctca cattgtctgc cacacaaatg 1307581 ggcttgattt tcagcagttt ttcgataggt tatgccattt ttaattttct tgggggcgtg 1307641 gcatccgacc gctatggggc aaagctgacc ttgtttgtcg cgatggttgt ttggtcgctg 1307701 tttagcggag cagtcgccct cgcttttggc tttgtcagcc tgctgattat acgcattctc 1307761 ttcggaatgg gagaaggccc gctttcggcg accatcaaca agatggtgaa caactggttc 1307821 ccgccgaccc agcgggcgtc cgttatcggt gtaaccaaca gcggcacgcc cctcggggga 1307881 gccatttccg gcccgatagt cggcatgatc gcagtggcgt tcagctggaa ggtatccttc 1307941 gttctcatta tgattattgg attgatatgg gcagtgctct ggttcaagtt tgtcaaagaa 1308001 aagccgcaag agacgatcaa ggaagcaccg gcaataaaag cagaaacgtc tcccggagaa 1308061 aaaattccgc tcacctttta cctgaagcaa aaaacagtcc tgttcacggc gttcgctttt 1308121 ttcgcttaca actacatcct cttcttcttt ttgacatggt ttccgagcta tcttgtcgac 1308181 gagcggggat taagtgttga atcgatgagt gtcatcacgg tcataccgtg gattttagga 1308241 tttatcgggc tggctgcggg gggatttgtt tctgactatg tgtacaaaaa aacggcccga 1308301 aaaggtgtgc tgttctcgcg caaggttgtg cttgtcacgt gtttgttttc atcagctgtc 1308361 ctgattggtt ttgccgggct tgtggcaacg actgcggggg ctgtcactct tgtcgctctg 1308421 tcagtgttct ttctttattt gaccggtgct atctattggg ctgtcattca agatgtggtt 1308481 gatcaaaaca atgtcggttc tgttggcggc ttcatgcatt tcctcgccaa cacggcagga 1308541 attatcggcc cggctttaac cggatttatt gttgaccaaa caggcacgtt ttctggagca 1308601 tttttgcttg ccggtgggct ggctgtcttc gcttcacttg ctgtgattcg ttttgtccgt 1308661 ccaatcattg gtaagccagc gggaacagaa gctgagaatc ctgtgtctta ttaatctgga 1308721 aatatagtgg gagaggcggt atgtttgatg atacaatata cagtaaataa tcgcagccgg 1308781 tatgataagg aagggaatta gatggtaacc ataaaagata tcgcaaaact cgcaaacgta 1308841 tcccacacta ctgtttccag agcactcaac aacagccctt acatcaaaga acatacgaag 1308901 aaaaaaatat tagagctagc agagcagctc aactatacac caaatgtaaa tgcgaaaagt 1308961 ctggcgatgc aaaagtcgca tacgatcggg ctattcttta caagcattac aaacggaacc 1309021 tcacacagct tctttgcaga cactatcaaa ggcgtcaatc aagccataag tgaggattac 1309081 aatctgtatg tgcgcggcat tgatgatctg aaaaactatg actccgttac accgatgaga 1309141 tatgacggca tcattttaat gagccaaagt gacattgata attcttttat ttaccatatt 1309201 cgcgaaaaaa acattccgct tgtcgtgctg aatcgtgata ttgatgatcg taccatcacg 1309261 aatattttgt ccaatgacaa ggaaggctct caagaagctg tagaatactt cattcagtcc 1309321 ggacatcaag acatcgccat catcgagggg atcgaaggct ttaaatcctc ccagcagcga 1309381 aaggaagggt acttatccgc actgattcaa catcatattc cgatcaagca tgaatacagt 1309441 gtcaaaggac agtacgatat ggaaagcggc tttcaagcga tggagcggct gctggcactg 1309501 ccgaatcctc caaccgctgt tttttgttcg aatgatgaca tggcaatcgg agcgatgaat 1309561 gcgatattcg caaagggcct gcgcgttcct gatgatattt cggtgatcgg gtttgatgat 1309621 attgggtttt cacagtacat cacgccaagg ctttcaacag taaagcgccc agtggagaaa 1309681 ataagcgtgc tcggtgcgca aaaactcttg tcgctgatca gcgagcccga aacaaaagca 1309741 gaaaaaatct tggaaaacac agaatttatg gtgcgtgatt cagtcagacg attgacgacg 1309801 tgatgtcccg tttttcagcg ggcattcttt atacagaaaa atgttaacgt gtgcataaag 1309861 tgagagggag gcaataaggg tgcagaagct gaataaaaat gtgtacgatc actatactca 1309921 gtatccagaa aaaattctcc aattcggaga aggaaacttt cttcggggat ttatcgattg 1309981 gcagattgat caattgaatc aacacactga ttttaatggg agcgtggcag ttgtccagcc 1310041 aagaggctca gaaaaaatca aacgattaaa tgagcaagat ggattatata cacttttttt 1310101 acaaggaatg aaagacggag aagcggtaaa cgagcatatg attatcaact caatcagccg 1310161 gggaattgac ctgttttctg attatgaagc atacaaagaa ttggcatcaa gcgaaaggct 1310221 tcggtttatt atctccaaca ccactgaggc tgggattgta tgtgatgaaa aagatcgttt 1310281 agaggatagg ccgcaaaaaa cattccctgg gaaattaact gcatttcttt actttcgcta 1310341 tcaggctttt aaaggagatc agacaaaagg gtgtgtcctg atcccatgtg aactgatcga 1310401 gaataacggt gaaaagctga gggaaacggt tcttcattat gcacatctgt ggaagctgga 1310461 ggaaggattt acacagtgga ttcatgaggc caatacattt tgtaatagtt tagtagaccg 1310521 gattgttccg ggttttcccg tcgacagcat tgatgagatc acggcagatc ttggctatca 1310581 ggatgatttg atagttgtgg gagagcaata ttatttgtgg gttatcgagg ggcctgattg 1310641 gattggaaaa gaacttccct ttgcggctgc agggctgcat acaaagatcg tcagcgacct 1310701 caccccatac cggactaaaa aagtaagaat tttaaatggc gctcatacag caatgacgcc 1310761 agtggcttta ttatacggct tgaagactgt tagggatgca gtcgagcatc cggaagtggg 1310821 gcgatttata agagagctga ttgatgacga aattcttcct gttttaaaaa tggaaggtct 1310881 ttctcagtat gctgacgatg tgctgaaccg ttttaaaaac ccgtatatta agcattacct 1310941 ggaaagcatt gcattgaacg ccatttccaa attcaaaacg agaaacctgc cgactcttaa 1311001 ggaatatgct gaacaaaagg gacagcttcc tgaacgcttg gtgttttctt tcagcgctct 1311061 tctgtatttt tatcatgata acgagacatt gcaggatgat ccggcagttc ttcaattttt 1311121 caaagaggtt tggtgtcagg aggatggcga catgcttcgg attgcatcaa gagtgttagg 1311181 cgaacagcgg ctgtgggggg cagatctcaa tgagataccg aagctgactg atagagtcgc 1311241 tgtttacttg aatcatattc atgagctggg catgcagagg gctcttgaac aatactgcat 1311301 acaaggggga gaggtacgtt gaagtcgttt ataaagattc ataagcaaga taatgtcctt 1311361 cttgctctgc gggatattca aaagggagag aggctgcatg cttacggcgt gtcgattgaa 1311421 gtaaaggatg atataaaaag aggccataag attgcattgc agtctatcaa agaaaacgac 1311481 agcatcgtca agtacgggtt tccaatcggt catgcatcac aagatatctc gatcggagag 1311541 catattcatg tccataatac gaaaacaaac ctgtctgata tccaattata cagctataca 1311601 ccgagatttg atgaaaatcc gtattctaat gagaaccgga cgtttaaagg ttttagaaga 1311661 gaaaacggag atgcgggtgt acggaatgaa ttgtggattg tcccaactgt cggctgtgtc 1311721 aatggaatag cagaaaaaat gctgcagcgt tttgtcagag aaacagggga tatcgctcca 1311781 tttgataacg tactggtgtt aaagcatcaa tacggatgct cgcagcttgg cgacgatcat 1311841 gaaaatacga agcagatcct gctgaatgcc attcgccatc caaatgccgg cggcgtcttg 1311901 gtgttagggc ttggctgtga aaacaatgag ctggcaagaa tgaaggaagc actgcaagat 1311961 gtgaacttga agcgggtgaa gtttctggaa tcccagtcgg tgaccgacga aatggaggca 1312021 ggcgttgctt tgctgaagga aattcatgaa gcggccaaag gagataagag agaagacatt 1312081 ccgctgtctg aactgaagat cgggctgaaa tgcggaggtt cggacggttt ttccggcata 1312141 accgcaaacc cgctgcttgg acgtttttca gattatctca ttgcacaggg agggagtact 1312201 gtgctgacgg aagtaccgga aatgttcggc gcagaaacca tcctgatgca gcgggctgcc 1312261 aatgaagaag tgtttcataa gatagtcgat ttaatcaatg atttcaaaca atactttatt 1312321 aaacatgatc agccggtgta cgaaaatcct tcaccgggca acaaagcggg cggcatttct 1312381 acacttgagg ataaatcgct gggctgtacg caaaaagcgg ggatttctcc tgtcacggat 1312441 gtcttgaaat acggtgaagt actcaagaca aaagggctga ctcttttgag cgcaccgggc 1312501 aatgatttga tcgcctcctc cgcattggcg gctgccggct gccaaattgt cctctttaca 1312561 acgggaagag gcacgccgtt tggcaccttt gtcccgacgg tgaaagtagc gacaaacacc 1312621 gagctgtatg aggcgaagcc gcattggatt gattttaacg caggcctttt agcagaggat 1312681 gatgttcatg aggaatatgt gctgcgtgag tttatccact atatgattga ggtggcaagc 1312741 ggccagcttg tgaaccatga aaaaaatgat ttcaaagaac tcgccatttt taaatcgggt 1312801 gtgacgttat aataagaaaa ggctatcctt caagcggata gccttcttca ttaaatcaat 1312861 tttaaaccgc tgactaaaat aatggaagcc ataataaatt gcagtggacg cggggagaat 1312921 cgaggcgaaa gatggctccc gatcagtacg ccgggaattg aaccgaggag cagattagct 1312981 gccagcatgt aatccacgct tccgaagctt gcgttcaaaa tgcctgctgc cgtaacaaga 1313041 agaaaagcat gcgcgatatc ggttccgaca atctgtgacg ctttcatgtt aaataagtaa 1313101 atcatggcga ttgcaaataa tgagccggac ccgattgatg ttaatccgac gataaaccca 1313161 aacacaacac caataagaat tgtcagcgcc ctcttatttt caagcggcat cagctgccag 1313221 cggttggggc gaagttttct atccaaaaac aaacgaacga tgattgaaat ggcaaccagc 1313281 gttaacacat atcctagagc gtgcttaata atttcttcct gatgctggtg aaaggcgggg 1313341 aacaaatgca atatgccaat ggctagcgaa gcactcggaa tactgccgat ggctaagtat 1313401 tttaccaatt taaagttaat cgttttctgc cgccaatggg aggcaacgcc aaacagcttt 1313461 gtgatcgagt tatatacaag atccgtaccg accgcgatgg aaggattaat tccaagcaca 1313521 attaaaaggg gagttaataa ggccgctcca cccactcccg tcaatccgac taaggctccg 1313581 acaaacaaac ccatcaatat gatgcttaca ctcatgataa aggcctcctg aaaacccgac 1313641 tagaattcac ccgaatctta ttcgcgttgg tcaagtatta attgtaagtg ctccatcggc 1313701 tgctgaaaaa cccgagctct atccgctccc tgatggtatc attcaattga caacacctta 1313761 tacatcagga gaacacgtct ttcaggtgca acgagcactt gcggctctgt atttttaccc 1313821 tgataaaggc gctgttaaca acggaattga cggcgtttac ggaccgaaaa cagctgacgc 1313881 agttgcccgt tttcagtctg ttaacggtct aactgctgac ggtatctacg ggcctgcgac 1313941 gaaagagaag atcgcagcgc aattaagctg atcaaagacc ataaaaatcc cggagccgct 1314001 ccgggattta ttttttcttc ttcaactttt ttataattcc agcactgcgc tccctcaccc 1314061 gaagcgagta cccggaaagc ccaaaccttc cgtaatcaac aaacttcaca cgcctcacca 1314121 attttttcac tgtatcacct gacattatcc tctgtttgta tttattatat gtcacccttt 1314181 aagaaaagga ataaggacaa gagctgtttt cccttgtcct tttagtgtga tcatgctttt 1314241 tttcgtttat actcgtcaat cagccgttcg ttttctttga agattcttgc tgtatgcgga 1314301 ctgacttgat agcttgcgac actggtggtt gaacgttttt tcaggatttt aaacggcttc 1314361 gccgctctgg gctcgcatct gttttgaaac gcacgttcca ttatccttca ccttcctcct 1314421 caattggcag caccaaatca tatatgctcg ttaatgacgt aaatagcaaa taatcaaatt 1314481 ccgtgacaat gctgtcagac gtcagcttga tgacatagtt ctgtgtctcg atggtaaaag 1314541 ggatgagaac cacttttccg tattggtcgt aataaacatc ctttcgatcg agccgtgttt 1314601 gtacatctgc cggatcatcc atatgctcgg ttaaccggtc tttatcagcc tgtgtcgaat 1314661 agtggcaaag agaagccgtt aagttcattt tatcagcata ggttttcagc agcttatcaa 1314721 taccttcagc ataagcatct atacttccat aataaacatg gatcggttcg tttttcaata 1314781 ggtattggta tgttttcagc cgattgagat acatgtggag catttcgttg ttttcttcaa 1314841 gaatttctct tgtgtctgtt tcaagctcgc tgccggccag ttttttgaca tatgcactta 1314901 agaagataaa agcatcaatc aaagcaaaac tgactgcgac aatgagatac cgttcccagt 1314961 gggtaaatag ggaagtgggc tcatatgtcc agtataccat agcgcccaga acaaacagca 1315021 aataccaagt tttccgaatg gcggacattt tttctttgac cttcgcttcg aaacgccacg 1315081 tggcatacac gtataacccc agtccggcca cgatgcacca gaccatgatc tgaaagaata 1315141 aaaccatatt cgaatccctc acatctgaaa taggttctgc ttattgtatt cgagagatcc 1315201 ggatggtttt cctgttccat caaaaaaacc gctcctttga cagaagcggt gtgacattaa 1315261 aatatcatat ttaaaataaa gtaggcgatg gcaccaagtg tcgctgaaat cggaagcgtg 1315321 atgacccatg taatgagcat tcgcttggcc gtaccccagt ttacgccttt tacgcggtgg 1315381 gacgcaccga cgccaagaat tgatgaagaa atgacgtggg ttgtactgac cggcaaatga 1315441 ataaacgtgg cgccgaaaat aatggctgct ccggttaagt cagcggaaac accgtttacc 1315501 ggacggattt tcatgatctt tccgccaacg gttttgatga ttttccagcc gccgattgat 1315561 gttccgagac ccatggctgt cgcgcaggcg aattgcaccc aggtaggaat atcattagca 1315621 gaagtatgta aattcgctgt gatgagagcc attgtgataa ttcccattgc tttttgcgca 1315681 tcgtttgttc cgtgtgtata cgattgcagg gcagctgtta caatctgcac tctgcggaat 1315741 tgcttattcg ttttcgccaa gttgctgtct ttgaaaatca gcttaacgat gctataaaga 1315801 ataaaaccaa ggacaaaggc aataattggt gatagaatca gtgcttcaat gattttaatg 1315861 aagcccttat agtttaacgc tgcaaatccg gctgccgcaa tggctgcacc ggcaatagcg 1315921 ccgatgatgg catgggatga gctgcttggg ataccgtagt accatgtgat aaggttccag 1315981 gcaattgcag cgagtagcgc agccaaaatg acaacagagc cattttccag cgtataagga 1316041 tctacgatgt ctttcgtaat ggttttggca acacctgtaa acgtcattgc tccgacaaag 1316101 ttcatcacag cagccaatat aatggcatgg cgcggtttta acgcttttgt tgataccgaa 1316161 gtcgcaattg cgtttgccgt atcatgaaac ccgttgatga aatcaaacgc cagagcacaa 1316221 atgactatta gtatcgttaa tattaataga atatccattt ttacccctcg ttacgcgttt 1316281 ttcataatga tggtttcaag attattggca acactttgac aagagtcggc gatttcttca 1316341 agcgtttcgt atatttcacg atattgaatg actttgattg gatctgtttc atttccgaaa 1316401 agattcttta atgattttct gtgcaagttg tcacaactgt gctcatactc tttaattttg 1316461 attgcgtgag gctgaatatc ctttaagcga ttttctgcca gcagctcgat cgtaatcaaa 1316521 atctctttcg cacattctct gatatatccg ctgaatttat caatatgctc gtctgatgaa 1316581 gtaattgaga aaatctccat catggcagag aaatgttcga ttccgtcaag cacatcatcc 1316641 aagctgtttg tcagctgaag gatatcttcg cgctcaatag gagtgatgaa cgctttgtta 1316701 agctctttaa tcatgacatg aacatgattg tcaccttttg tttcatattc ctttaacgta 1316761 tctgcaaatt ctttaagagt cgtttggtta gtgaccttaa aattcacaaa atattctgca 1316821 gtttcgtcta tgttctttgc aatttctgtt aaaaggagtg agaacttatc tttttttctt 1316881 cttatcatta aaaaccctcc atagtttgaa tgaacaatgc acacatcaaa ttattatata 1316941 gccttttgtc gaaaaaaaac aggtaaagtc gaaaaaaacg tatcttgact tttttgataa 1317001 atcgtgtctc cttattttga cctacttcgc tttaaaaaaa cgacccaagt ttgcaaaaac 1317061 tttctgctta acgtaaaaag tatatcaaaa gttgtgtttt tcctgtcaac ttttatcttc 1317121 tgtttcacca aaaaacggtt ccctaaacaa gggaaccgtt ttatcagctt gcttttcgtt 1317181 ttttcatccc gtaataaaca ggcagtccgg caaggccgat gaggatggat aatccgcagc 1317241 tcattgtatc tgtaatgagt gtgctgccta acacaaagaa ggagcccgcg attgccagaa 1317301 ttggcataaa tggataaagc ggaacactgt aggcgcgctt ttctcccttt gctcgcttgc 1317361 ggagaataaa cactgcaaaa aaggccatca cataaaaaat gtagatcatg aaaatggaga 1317421 tttctgagag cttatcaggg ttgctgatca gcatcataat caaagccaaa gcaatttgaa 1317481 aagaaatcgc aatccatggt gtgcggaacg acgggtgtac atgtgacagt ttttcagcaa 1317541 atggaagctg tttgcgttcc gccattgcaa atgaaacacg cgggaaagaa agcacctttc 1317601 catttaagca cccaaagatg ctgacgataa tccctacact gatcagcttt ccgccaattg 1317661 aaccgaacag catggttgca gcggtgcttg tcgcattttc accaagcgtg acaatttcgt 1317721 tcgctgacag gatgtgaagc aatgcaaaat taatgaaaat atagatcgcc gttacaatta 1317781 ataatccgcc cgtcatagcg cgtggcagca gcttttcggg atttttcatt tctccgccga 1317841 gagcggcaag gagaatccat ccgtcataag caaacaacgt agctaaaata gccgccccga 1317901 agttcatatc agaaatgctt tcgtttactg ctgtgaagat gtgctgatcg cctttccaaa 1317961 ggccaaagac gatgatgcag gcaatcggaa tcagttttcc gatcgttgtc agcgtttgga 1318021 caaaaccgcc gtattttgta ccgataatat taatgacgca taaaaagaga actgctataa 1318081 ttccaatgac ttttgatagt ccagatcccc agccgaaaag attcgccatt aaagatccaa 1318141 aatataaacc cagcgcgcca ataatcgccg ggccgtaaat gataatctgc acccagccgc 1318201 acaaaaatcc ccaaaactcg ccgtacactt cttcaaggta cgtataaagc ccgccggttt 1318261 ttggaatctg cgttccgatt tccgcgattg tcaaaccgcc cgccagtgtt aaaataccgc 1318321 ctaacagcca ggcgaaaagc gccatttttg aatcacctga ataagcaagc acagcgccgg 1318381 gcttcataaa aacaccagaa ccgataatgg ttccgatgac aagagtaagg gcaaacaaga 1318441 ggcctatctc ttttttcaaa ccgttgtctt cagtatgcat gtccttaacc tcctatgatg 1318501 ttgaagcttc atgttgaaga atctattttt tcatattgta aaccctattt tagaaaagtg 1318561 aaataaaata aattttctga ttttcgaaat ttgctttgtg tacagcagat aaaactgtag 1318621 aaatacctgt tttaatggtc tataaacgaa taaaattcat aatttttatt tacaaagttc 1318681 gtgttttatg tattaggatt ttagccggta cagaggggag atgagaattc agaaaatgaa 1318741 cgaaccttcg gtgaagctga tatgttgact ttctcatgcg aataaaatac tttgttatta 1318801 gaacaataaa tatacaatta tgatatgata tctcgaaatc gagataaaat aacctggagg 1318861 gacagcatat gaaagttaac ggcattcacc acgtatcggc attaacggcc gacgcacaaa 1318921 aaaacttgga tttctataag aaagtattag gattaaagct cgtcaaaaaa tccgtcaatc 1318981 aggatgaacc gacaatgtac catctgttct acggagatga agtggcaaac ccgggaactg 1319041 agctgacgtt tttcgagatt ccccgcattg caccgtttca tgcgggaaca aacagtattt 1319101 cttctattgg attgcgcgtt ccaggcacag aagccctgca ttactggaaa gaacgttttg 1319161 aagagcagca agtaacgcac agcggcatct ccaaaagagc cggacgtgac atattggcat 1319221 ttcaagatca tgaggggcag cgacttgtgc tgactgctga tgaggaagga aaaggatatg 1319281 gcctgcctgt taaacagagc ggcattccgg aagaattttc gtttcgcggg ttagggccgg 1319341 ttgaactgac tgtgccatat gctgaaccaa ctttacacgt attgacgaat attcttggat 1319401 ttacagaaat cagccgtgaa ccagtcgaag ggcaaggaac cgccgttatt ctggaatcag 1319461 gagaaggcgg tgctgcaacg gaaatccatt taatagaaag aaacgatctt ccgcgagagc 1319521 gtcaaggcaa agggagtgtt caccacgtcg catttcgggt aagagatgaa gaagaacttg 1319581 ccgggtggca ccggatcatc agccgcgaag gctttagcaa ttcaggcata gttgagcgct 1319641 actatttcaa ggcgctgtat ttcagagaac cgaacggcat tttgttcgag ttatcaacag 1319701 acggaccggg ctttatggta gatgaaaatc ttgatgagct tggccaaacg attgctcttc 1319761 cgccatatct agagcatcga agagcagaaa ttgaagcaaa attgaaaccg atccaataaa 1319821 ttgtgattct tttgccttcc ggcgccgccg gagggctttt tttattacca taattaattt 1319881 tgacctaaac agcatgcctt attagggagg aaatatcaga tgctgattgg gagaaatggc 1319941 ttaaaaccct ttgcaaatat gggtgattgg tatggaatgg cctcggcaaa aatattgtct 1320001 ttgtttatta atagtttatt catatttgct tgttacacta tttcaaagtt agacaaaaag 1320061 gagtgaaaaa taagtggaaa agaaaaaacg cgagctggat atcgtcctcc tcctcatttt 1320121 gctcgcatct gcattcttaa atatctataa catttggaag gacgacacgg tgaatcctta 1320181 ttacaccgcg gcagttacaa gtatgatgca aagctttcat aatttctttt atgcttcgtt 1320241 cgatgctgcc ggctttataa cagtagataa accgcctgtt acataccaaa tccaaacgat 1320301 cagcgcactg atattcggta tgcacggctg gagcgtcatc ctgcctcagg cacttgctgg 1320361 tgtaggttct gtccttctta tgtacttgct gataaagccg acatttggaa aaacggcggc 1320421 gcgtattgcc tcatttgtta tggcatgtac gccgatagct gtagctgtag cacgtacaaa 1320481 caatgttgat gcattactgg tatttttctt attgcttgct acatggcttc tctttaaagc 1320541 gatcagaaaa ggaaagctga tctggctgtt agcagcattt ttcgttgttg gagtaggttt 1320601 taatacaaaa atgctgcagg cttacatgat tttaccggct ttcttattgt tctatctgat 1320661 tgcggcaaac gccacaatca agaaaaaaat cgtttcattg gtaagtgcgt tagccgtatt 1320721 agcagccgtt tcgttatcgt ggccgctcat tgttgacaat atccctgcaa gcaagcggcc 1320781 ttatatcgga agcagccaaa ccaactctgt tttggaattg gctttcggct ataacggaat 1320841 ccagcggctg acaggccaaa attcaggcgg cggccagggt gcgccaaaca aagacgcttc 1320901 aaaagaaatg tcttcttctg ataacactca agcaccgcct aatcagtcat caagcaacag 1320961 ctcatcaagc gatggtaaat cctcaaatgg caatatggcg gcgcctccat ccaatggcca 1321021 aatgccaagc ggcggtcaag gaggccctcc aagcggcgga gatggcggcc aaggcggacc 1321081 cggcggagac ggagggaaag gcggtacagg aaccggttcg aaaatgcaat caggttcagg 1321141 gatgtttgga acgggaacac ctggtccact gcggcttttc caacaagagt tatctgatca 1321201 aatcagctgg cttctgccat ttgcgatatt tggaatcgca ggcttactga tcgctggcgc 1321261 aagagaaaga agaagattat ctgtagagca gaaggaaacg gtgttctggg ttgcgtggct 1321321 tgtaccgatt gccggattct tcagtgtcgc agaatttttc catcattatt atctcatcat 1321381 gctggcaccg ccgattgcgg ctcttgtcgg tgcggggtgg gtcgctcttg ttcatctgta 1321441 ccgcaatcag acaggctgga aagcatggct tttgccggga gcaattattg cgacaactgg 1321501 atttgaattg tttattctca gaaactacaa cgatcaaatc ggtgttggat ggagtatcgg 1321561 ggtaggtgtt atcggcgtgt tgtcagcgat tgctttgctg ctgtttaaac agcgccaaaa 1321621 accgttcagt tattatgttt cacttgcagc tctcctcgca ttgctggtga tgccgatgta 1321681 ttgggcaagt acaccgcttc tgtacggagg caacagctca ctgcctgaaa caggccctca 1321741 actcgcatca atgagcggaa aaggcatggg aatgtctgat gcgactgtaa atgaaaaact 1321801 gatcaaatat ctagaggaga ataactccgg agctgaatac ctattcgcca caaccgattc 1321861 gaacacagcg gcaccatata tcattaaaac gaaaaaagct gtcatggcta ttggtggata 1321921 cagcggttct gacccggcaa tcacactgac tcaattcaaa aaacttgtaa aagaaggaaa 1321981 agtgaaatac ttcttggctt ctggaatggg aagaggcgga aacaatgaca ttgttgaatg 1322041 ggttgagaaa aatggaaaag aagtagcatc agaaaaatgg caatcaagtt ctgatcaaaa 1322101 aacagaaaat actgattcag ctgatacatc aagcagcaag gcttcaggtg aaaacggcaa 1322161 aatgggcgga cctggcggaa tgaatcagtc agcaacatta tacgaactac atgctgatga 1322221 ataggaggca aaaacatgag cagacatatt caatattcaa ttgttgtacc tgtgtataat 1322281 gaagagcttg tcattcatga aacctatcag cgcttaaaag aggtcatgga tcaaacgaag 1322341 gaaaactacg agctgctttt tgtcaacgat ggcagcaaag accgcagtat tgagatttta 1322401 agagagcaca gcctgatcga tccgagagtg aaaattattg atttttcaag gaattttgga 1322461 catcagatcg ccattacggc aggtatggat tatgcacagg ggaatgcaat cgtcgtcatt 1322521 gacgccgatt tgcaggaccc tcctgaactg attttagaaa tgattgaaaa gtggaaggaa 1322581 ggctatgaag tcgtgtacgc cgtacggact aaacgaaaag gggaaacctt tttcaaaaaa 1322641 caaaccgcgg ctatgtttta ccggcttctc agcggtatga cagatattga tatcccgatt 1322701 gatacggggg attttcgcct catggacaga aaagtctgtg atgaaatgaa gagattaaaa 1322761 gaaaaaaatc catttgtaag agggctagtc agctgggtgg gtttcaaaca gacagcggtc 1322821 gagtatgtac gtgatgaaag gctcgccgga gaaacaaagt acccgctcaa gaaaatgctg 1322881 aagctgtcaa tggacggcat cacgacattt tcacataaac cgctgaagct ggcaagctat 1322941 gcggggattt taatgtcagg tactggattt ctgtatatgt ttatcgtgct gtatctgaag 1323001 ctattcacag acagcacgat taccggctgg tcatcactta ttgtgatcca gctcctgttc 1323061 agcggcattg tccttctgat tttgggcgtg attggcgaat atatcggcag aatctacgat 1323121 gaagccaaag acaggccgct ttacatcgtc caaaaatcgt atggaattga aaataaaaga 1323181 ctctatagag accagcatat gtcataacct caaaccccct gtccgtaatg gacagggggt 1323241 ttttatgctc tgagcacgat ctaaagcaaa agatgctgat agatatatgg aaattgggta 1323301 aagaagagat tgtgagcttg tactgcggtt cagtcatgct gaaataaaaa cagcaaaact 1323361 taaagatttc gtcctcggct ttgctgcatg tcagctgtta tattgggggg cttttaagaa 1323421 acgcatgatt agagccgtac cagttatgtt taatagaata ctcgtaccca atacaattcc 1323481 ccacgtcaac gtcgattcag agagaagaaa gctcagcaaa agaaaagcca atcctgcgca 1323541 gatcataccc agtcccacgg ttttcatgtt catgcctcct agcaaacgat gtttctagca 1323601 tctgatgtga atgatgtcaa tctgtatgat atacggatat ctcgtcagaa agtttcatag 1323661 aacaattagg tcttttatct aataaaaagc ctcagaccgc ttttacggcc tgaggcatta 1323721 tgtcttacga agttttctct tctttttgat ccagtttaat ttttttcgtc atttctttgc 1323781 cgtttcggag aattttcact tcaacggtat caccgatctt tgcgtcttta tataagatat 1323841 tgcgcaattc actgcctgta tcaatttctt taccttttag gccgatgata atatcctccg 1323901 cttttaatcc ggccttttca gcaggagagc ctgaagcgac ctcacggatg taaacgcctt 1323961 tattcagctg gctgccgaac aggccgagtg tgccttcttg gtaattttgc ggcacttgct 1324021 ctagatcaag catgctgaca ccgatatatg gacgttcaat ttgtccttta gacagcaatt 1324081 cttcagcaat cggttttacg tcattgcttg gaatggcgaa tccgataccc tcaacatcat 1324141 cctcactgat tttcatactg ttaatgccga caattttgcc gtctgtattt aacaaaggac 1324201 cgccgctgtt acctggatta attgctgcgt ctgtctgaat gacgttaatg ctcgtttcgc 1324261 cggctgatgt agacattgaa accgttctgt ccacgccgct tacaattcct tgtgttactg 1324321 tgcgggacag gtcttttcca agcggatccc caatcgcaat aacggtctcg cctgttctaa 1324381 gatcagatga atcaccgaag tttgccactt ttgtgacgtg gtcatcactg atttggagga 1324441 cggctaaatc agttaacgag tcactgccta ccagctttgc agtaacctca gtgccgtcat 1324501 ataaagatac cttcagtgat gatgcccctt ctacgacgtg gttatttgta atgatataag 1324561 ccttgccatt ctcttttttg aaaatgacac ctgaccctga accgctttct gtatcttcgc 1324621 tggaatcaga agaactagag ccgaacaaag agctgtttga ttgtgcctga agatttgtaa 1324681 taccgacaat cgctggtgaa aggtcttcta ccatatctga gattttagaa gagtcctcgc 1324741 tcttgaatgc agatgagctg cttgagcttt ttttagattc agaggaggtg cttgttgctg 1324801 taacagattg cgtttgctgc tggctggatg attgttttgc agtgtcctga gaatcatggt 1324861 caccaagcgg tgtaaacgtg taaatgccaa gagcaagact gccgccgatc actccgccaa 1324921 gcaacggtct gaaccatccg aatcctcgtt ttttcttctc ctgatcatga atgacattgc 1324981 gggccgagta ggaggcgctc tgatcgttct ctttcgttaa aaagacctca ttctcattac 1325041 ctttcgttct gttttcatca cgatagttat ccatcatgtt cactccgttt ctctattttc 1325101 acatgtctat ttatattgat aggtttatga cttgagttta tcataaacaa aaactgtggg 1325161 ataaaaatga aaagattatg ggaaattgtg aaaaagtgcg gaaaacggta cacttcatat 1325221 tgtatatgaa aggactgagt cgatggaaca gattggattg attggatatg gcagcatggc 1325281 ggatatgatc gctagacagc tgttgaaaca tgaacaaata aaagagaatg agctatttat 1325341 tgagacgaga acgaaggggg agcggctgcg ggcactcatg tcagattatc caaacgtatc 1325401 ggctgatccg ttggagaatt gggcaaatac gtgccaattg attttgatat gcgtcccgcc 1325461 actccatgtc atcgaaacaa tgcgccgtct gtacccgtat gtgaacagaa atactcacat 1325521 cgtatccata gctgccggtg tgccgctgcg tcttttggag gcagaaacag aagccggtat 1325581 ctcacgtgtt attcctgcca ttacgtccga agcagaagcc ggcatctcac ttgtcgttca 1325641 cagtgaagca ctggctgcag agaaaaaaga acgtctgaat gaattgttat cggttttcag 1325701 ccgtgtacgg gaaatcaaag aatcgaattt agatgtggcc agcaatttaa cgagctcggc 1325761 accgggattc atagctgcaa tctttgaaga actggcactg tctgccgtca gaaacagcag 1325821 cctgtccaaa gaagaagcct ttgattttct gattcattcg ctatacggaa ctggcaagat 1325881 gctgatcgaa aaaaatatgt ctttcgagga gacgctggaa cgtgttgcaa ccaaaggcgg 1325941 aataacggga gagggagctg aggtgataca cgcctctgtg ccggacgttt ttgatgaggt 1326001 atttgaaaga accctgagaa aatatgaact gcttacagaa caggttggta aacaaacatg 1326061 aatccttgaa agaggattct ttttttatca ctgaatgatt gagatttttc ccagttatat 1326121 tgcatttttc ctcttttttt aatataattt gttagaatat tcataattta gtaaaaaagg 1326181 aggagcgtta tgaaattgta catgtcagta gatatggaag gtatttcggg tcttccggac 1326241 gatacctttg tggattccgg caagcggaat tatgaacgcg gacggcttat catgactgaa 1326301 gaagcaaact actgtattgc tgaagcgttt aacagcgggt gtaccgaggt gctggtcaat 1326361 gacagtcatt cgaagatgaa taatctgatg gttgaaaagc ttcaccctga agcagacttg 1326421 atttctggtg acgtcaaacc attttcaatg gtggagggac tggatgatac gtttagaggc 1326481 gctttgtttc tcggttatca tgcgagagcc tcgactcctg gtgtcatgtc acacagcatg 1326541 attttcggcg tccgtcattt ttacataaac gatcggcctg tcggtgagct tggattaaat 1326601 gcatacgttg ccggttatta tgatgtcccg gtattaatgg tagccgggga tgaccgggcg 1326661 gcgaaggaag cagaagagct tatcccgaac gtgacgacag ccgcagtcaa acaaaccatt 1326721 tcaagatccg cagtgaagtg cttgtcgcct gcgaaagccg gacggctgtt gacagaaaaa 1326781 accgcatttg ccctgcaaaa caaggacaaa gtcaagccgc tcacaccgcc tgacaggcca 1326841 gttctgagca ttgaattcgc caattatggc caagcagaat gggcgaatct gatgccggga 1326901 acggaaatca agacgggaac tacaaccgtt caatttcagg cgaaggacat gcttgaagcc 1326961 tatcaggcga tgcttgtcat gactgagctt gcgatgcgga catcattctg ctaaaggggt 1327021 gttttaggct ttggcgcgat acatgataaa gcgtttttgg gcaatggcag ctacgatttt 1327081 ggtgattacc accctgactt ttgttctcat gaaggtcatt cccggatctc cttttaacga 1327141 ggagagaggc acaaatgaag ccgttcaaaa aaatctcgaa gcctactatc acttagacga 1327201 tcctctcatt ttccaataca ttttctactt aaaatccatc attacattcg atttcggacc 1327261 ttcaattaaa aaaccgtcgg acagcgtaaa tgatatgctg gaacgcggat ttcccgtttc 1327321 ctttgagctt gggatgacag cgattgtcat tgctgtgatt tctgggctgg tgctgggcgt 1327381 aatcgctgca ctccgccgca atggcttttt ggactacgcc gcgatgagtc ttgcagtact 1327441 cggcatctcc atcccgaatt ttattctggc aacattgctc attcagcaat ttgctgtcaa 1327501 tctcaaacta tttcccgctg cgacatggac gagcccgatt catatggtgc ttccgaccgc 1327561 agcgcttgct gtagggccaa tggcgatcat tgccaggctg acacggtcga gcatggtcga 1327621 agttctgaca caggattata tccgcacagc aaaagcaaaa gggctttctc cgttcaaaat 1327681 tatcgtaaaa cacgcactca gaaatgcact catgcccgtc attaccgtcc tgggcacact 1327741 cgtcgccagc atcttaacag gaagctttgt cattgaaaaa atctttgcca ttccgggaat 1327801 gggaaaatat tttgttgaaa gcattaatca gcgggactac cccgtgatta tgggaacgac 1327861 cgttttttac agcgtcattc tgattatcat gctgtttttg gtcgatttgg cctacggtct 1327921 cttagacccg cgcattaaac tgcataagaa agggtgaagc gtgtgaatct ccctgtacaa 1327981 acggatgaac gccagccaga acagcacaat caggtgcctg atgagtggtt tgtcttgaat 1328041 caggaaaaaa atcgggaagc cgattcggtc aagcggccga gtttgtcata cacgcaggat 1328101 gcctggagga ggctgaaaaa aaataaatta gcgatggccg gactctttat tcttttattt 1328161 ctttttgtca tggcagttat cgggcccttt ttatcgcccc atagtgtcgt acgccaatcg 1328221 ctgacagaac aaaatcttcc gccctcagcc gatcattggt tcggcaccga tgaactcggc 1328281 cgggatgtgt ttacccgaac atggtatggc gcgagaatct cgttgtttgt cggcgtgatg 1328341 gcagcactga ttgatttttt gatcggtgtc atttacggag gcgttgccgg ctataaaggc 1328401 ggcaggattg acagcattat gatgcggatt atcgaagtgc tgtacggact gccgtatctg 1328461 cttgttgtca ttttgctgat ggtgctcatg ggaccgggac tgggcacgat tattgtggcg 1328521 ctgactgtga ccgggtgggt cggcatggcg agaattgtaa gaggccaggt gcttcagatt 1328581 aaaaattatg aatatgtact cgcctcgaaa acctttggcg cgaaaacctt tcgcatcatc 1328641 cggaagaatt tgctgccgaa tactatggga gcgatcatcg tacaaatgac attaaccgta 1328701 cctgccgcca tattcgcaga atcattttta agctttctcg gcctgggcat acaggctccg 1328761 tttgcaagtt ggggcgtgat ggcgaatgac ggcctgccta cgattttatc tgggcattgg 1328821 tggcgcctgt tttttccggc ctttttcata tctctgacga tgtacgcgtt taatgtgctg 1328881 ggggacggat tgcaggatgc gcttgaccct aagctgagga ggtagctgta tggaaaaagt 1328941 tctgtcagtc caaaatctgc acgtgtcttt tacgacttac ggcgggacgg ttcaggcggt 1329001 cagaggggtg agctttgatt tgtataaagg agaaaccttt gcgatcgtcg gcgaatccgg 1329061 ctgcggcaaa agcgttacct cccaaagcat catgggcctg cttccgcctt attcggcgaa 1329121 ggtgacagac ggcaggattc tatttaaaaa caaagacctt tgccgtctct ctgacaaaga 1329181 aatgagaggt ataaggggag ccgacatttc tatgattttt caagacccga tgacggcgtt 1329241 aaaccctacg ctgactgtcg gcgaccagct gggggaagcg ctattgcgcc acaaaaaaat 1329301 gagcaaaaaa gcggcacgga aagaggtgct ttccatgctg tcattggttg gtattccaga 1329361 tcccggagag cgcctaaagc aatatcccca ccaattcagc ggcggtatga gacagcggat 1329421 tgtcattgcg atggcgctga tttgcgagcc tgatatctta attgcggatg aaccgaccac 1329481 cgccctggat gtaaccattc aggcacagat tttagagctg tttaaagaga ttcagagaaa 1329541 aacggatgtg tctgtcattc tgattacgca cgatttaggg gttgttgccc aggtagctga 1329601 cagagtcgca gtcatgtatg ccgggaaaat ggcggaaatc ggcacaagaa aagatatttt 1329661 ttatcagccg cagcacccat atacaaaagg cctgctgggc tctgtcccgc ggctggattt 1329721 aaatggcgct gagctgaccc cgattgacgg aacgccgccg gatttatttt cgcctccgcc 1329781 gggctgcccg tttgccgccc gctgtccgaa caggatggtt gtgtgtgaca gggtgtaccc 1329841 gggccagacg atcagatctg actcgcacac cgtcaactgc tggctgcagg atcaacgagc 1329901 agagcatgcg gtgctgtcag gagatgcgaa ggattgaaca tgaaaagggg gaagaggatg 1329961 aaacgagtga aaaagctatg gggcatgggt cttgcattag gactttcgtt tgcgctgatg 1330021 gggtgcacag caaatgaaca ggccggaaaa gaaggcagtc atgataaggc aaaaaccagc 1330081 ggagaaaagg tgctgtatgt aaataatgaa aatgaaccga cttcattcga tccgccgatc 1330141 ggctttaata atgtgtcatg gcagccgtta aataacatca tggaggggct gacgcgtctt 1330201 ggcaaagatc atgagcccga gccggcaatg gcggagaaat ggtctgtttc gaaagataat 1330261 aaaacttaca catttacgat tcgggaaaat gcgaaatgga caaacggaga tcctgtaaca 1330321 gccggagact tcgaatacgc gtggaagcgg atgcttgatc cgaaaaaagg cgcttcatcg 1330381 gcattcctag gttattttat tgaaggcggc gaagcatata acagcgggaa agggaaaaaa 1330441 gacgatgtga aggtgacggc aaaggatgat cgaacccttg aagttacact ggaagcaccg 1330501 caaaaatatt tcctgagcgt tgtgtccaat cccgcgtatt tcccggtaaa tgaaaaggtc 1330561 gataaagaca atccaaagtg gtttgctgag tcggatacat ttgtcggaaa cggcccgttt 1330621 aagctgacgg aatggaagca tgatgacagc atcacaatgg agaaaagcga cacgtattgg 1330681 gataaggata cagtgaagct tgataaggtg aaatgggcga tggtcagtga cagaaataca 1330741 gattaccaga tgtttcaatc aggggaactt gataccgctt atgtccctgc tgagctgagt 1330801 gatcagctgc ttgatcagga taacgtcaat attgttgacc aggcgggtct ctatttctat 1330861 cgatttaatg tcaacatgga gccgttccaa aatgaaaaca tcagaaaagc ctttgcgatg 1330921 gctgtggatc aagaggaaat tgtaaagtac gtcacgaaaa ataatgaaaa accggcgcac 1330981 gcctttgtat cgcctgggtt tacgcagcct gacggcaaag atttccgtga agcaggcgga 1331041 gacctgatca agcctaacga aagcaaagcg aagcagctgc tcgaaaaggg catgaaggaa 1331101 gaaaactata ataagcttcc tgcgatcacg cttacttaca gcacaaagcc ggagcataaa 1331161 aagattgccg aagctattca gcaaaaattg aaaaatagcc ttggagtcga tgtgaagctg 1331221 gccaatatgg aatggaacgt atttttagag gatcaaaaag cgctgaaatt ccaattctct 1331281 caaagctcat ttttgcctga ttatgcagac cctatcagtt ttctggaagc ctttcaaacg 1331341 ggaaattcga tgaaccgcac aggctgggcc aataaagaat acgatcagct gatcaaacag 1331401 gcgaaaaacg aagccgatga aaaaacacgg ttctctctta tgcatcaagc tgaagagctg 1331461 ctcatcaatg aagcgccgat cattccggtt tatttttata atcaggttca cctgcaaaat 1331521 gaacaagtaa aaggaattgt ccgtcaccct gtcggctata tcgatttaaa atgggcagat 1331581 aaaaactgat ggaggcgatt gaggaaatac tgcttcttta tgcgaaggag cggtattttt 1331641 tctctttctt gcacgtatac gtagggtgca gagcaaatga aaggagtgtt ttcgttgaat 1331701 tacaagccga aagcgttgaa caagggtgat acagtcggag tgatcgcgcc cgcaagtccg 1331761 ccggatccaa aaaagcttga caccgcgctt ttatttttag aagagctcgg tcttcaggtg 1331821 aagttgggca aggcgctgaa aaaccagcac ggctatttag cgggacagga tgatgagcgg 1331881 ctggcggatc tccatgagat gttcagagac gatgaggtaa aagcagtgtt gtgcgcatgc 1331941 gggggttttg ggacaggacg tatcgccgcg ggcattgatt tcagcttgat ccgcaaacac 1332001 cctaaaatct tttggggata cagcgatatt acgtttttac atactgccat tcatcaaaac 1332061 acaggtcttg tcactttcca tggcccgatg ctcagcacgg atattggcct tgacgacgtt 1332121 cacccgctga caaaagcgtc atataagcag ctcttccagg agacggaatt cacctataca 1332181 gaagagcttt ctccgctgac cgagcttgtt cctggaaaag cggaaggcga gcttgtcggg 1332241 ggaaatctgt ctttgctgac gtctacactg ggcacgccat ttgaaattga tacgagagga 1332301 aagcttctgt ttattgaaga tattgacgag gagccttatc aaatcgaccg gatgctgaat 1332361 cagctgaaaa tgggggggaa gctgacggac gcggcgggaa ttctagtttg tgattttcac 1332421 aattgtgtcc cggtgaagcg agagaagtct ctctcgcttg agcaggtgct ggaagactat 1332481 attatttctg cgggcaggcc tgctctgaga ggatttaaaa tcggccactg ctcgccaagt 1332541 attgccgttc cgatcggtgc gaaagctgct atgaatacag cagaaaaaac agccgtaata 1332601 gaggcgggcg tttcagaagg ggcgctgaag acatgaaaat cattcgaatc gaaacaagcc 1332661 gaatcgctgt cccgctgaca aagccgttta aaaccgcact tcgcactgtg tatacggctg 1332721 aatcagtcat agtaaggatt acttatgaca gcggtgcagt cggatgggga gaagcacccc 1332781 cgacgttagt gattacagga gacagcatgg atagcattga aagtgccatc caccatgtgt 1332841 tgaagccggc attgcttgga aaaagcctgg cgggctatga ggccattctg cacgacatcc 1332901 agcatcttct tacaggaaat atgagcgcga aggctgctgt agaaatggct ctatacgacg 1332961 gctgggcgca gatgtgcggg ctgccgcttt atcaaatgct tggcggatat cgagatacgc 1333021 tggaaacaga ttatactgtc agtgtcaact cacctgaaga gatggcagct gatgccgaga 1333081 attatctcaa acaaggcttt caaacgctga aaataaaggt cggaaaagat gatattgcaa 1333141 cagatatcgc ccgtatccag gaaatcagaa aacgtgtcgg atcagctgtg aaactgcgtt 1333201 tagacgctaa tcaggggtgg aggccgaagg aagcggtaac tgccattcgg aaaatggagg 1333261 atgcgggcct aggcattgag cttgtcgagc agcctgtcca taaagatgat ctcgctgggc 1333321 ttaaaaaggt gacagatgca acagatacgc cgattatggc tgatgaaagt gtttttacac 1333381 cgcgccaggc gttcgaagtt ctgcaaaccc ggagcgcaga cttgatcaat attaaattga 1333441 tgaaagcggg cggcatcagc ggagcagaga aaattaatgc catggcggag gcctgcgggg 1333501 tggagtgtat ggtcggcagc atgatcgaaa cgaagctggg cattacggcc gcggcgcatt 1333561 ttgcggcaag caagagaaac atcacacgct ttgattttga cgcgccgctg atgctgaaaa 1333621 cagatgtatt caatggcggc ataacatata gcggcagcac gatttcgatg cctggcaaac 1333681 cgggcctcgg aatcatcggg gctgcgcttt tgaaagggga aaaagagcaa tgatgcacac 1333741 tgtcatatca gcagtggcca acatctggac agcgcctgat tcacctcgtc cgtctgatca 1333801 attcatgctt caaccgactg taatgatcag agactggctg gagcgcatga cgtatgatga 1333861 acggcttgga ttatgtacag acaatgtaat ccaaactcag gttctctttg gcgaaaaggt 1333921 acttgtgacg gcggaacagg gggaatgggt ttctgtgatc gtgcctagcc agccatcccg 1333981 aaaggatccg cgcggatacc cgggctggat gaaaaagtac cagctggaaa aaacaaagcc 1334041 catccataca caacacgatg tgatgatcag caaacctgct gcctttttgt acagaagcaa 1334101 tggggaaaag gagatcgaat taagcttttt gacagttctg ccccttattg caaaagaaaa 1334161 cggatatttt aaggtttcga ccgtttttgg ggaaaggttt gtgaggcaaa gtgatgcagt 1334221 gcctgtcagc caacagaaag ggactgctga agacatcatt caaacgggtg cgttttttct 1334281 tggccttccc tacctgtggg gagggatcag cgggtttggg tttgattgct ccggatttat 1334341 gtacagtata tttaaggcga atggatacag catcccccgt gatgcgggag atcaggctaa 1334401 ggcagggaag ggtgtcccgc ttgatgatat gaaagccggt gatctgctgt tttttgctta 1334461 tgaggaagga aaaggagcga ttcatcacgt cggtctgtat gtaggcggcg ggaaaatgct 1334521 tcattctcca aagacaggga agtcaatcga aatcctcaca ttaacagaga caatctatga 1334581 aaaagaatta tgtgcggtgc gccgctgttt ttcagaataa ggagggagac aaatgaggcg 1334641 actgcctttg ttagaggtca gccagctgaa aatgcatttt gacgcaggga aaaagcggac 1334701 agtcaaagct gtcgacgggg tcacctttca gattcgtgaa ggagaaacgt tcgggctagt 1334761 cggggaatca gggtgcggga aatcaacctt ggggagagtg ctgatgcgcc tttatcagcc 1334821 gacagaagga agcgtgacat accgcggcac aaatcttcat gcactaagtg aaaaagagca 1334881 gtttgccttc aaccgcaaac tgcagatgat ttttcaggac ccttatgctt cacttaaccc 1334941 gcgcatgacc gttcgagaaa ttattttgga gccgatggag attcataatc tctacaatac 1335001 ccataaagca cggcttctcg tcgtggacga gctgcttgag gcagttgggc ttcaccccga 1335061 ttttggcagc cgttatccgc atgaattcag cggcgggcaa aggcagagaa tcgggattgc 1335121 gagagcactg tcgctgaatc ctgaatttat cgtggcggac gaaccgattt ctgcacttga 1335181 tgtctctgtt caagcgcagg tggtcaacct gctgaagcgg cttcaaaaag agaaagggct 1335241 tacgttttta ttcattgccc atgatctttc gatggtgaag catatcagtg acaggatcgg 1335301 tgttatgtac ttaggacaca tgatggaaat tacagagagc ggcaccttgt atcgtgaacc 1335361 gctccatccc tatacaaagg cgcttttgtc ctcgattccg attccagatc ctgaattgga 1335421 ggacaagcgt gagcgtattc tcttgaaagg ggagctgccg agcccggtca atccgccaag 1335481 cggctgcgtg tttcgtaccc gctgtccgga ggcgatgcct gaatgtggag aatctcgtcc 1335541 ccagcttcaa gaaatcgaac ccggccgttt tgtcgcttgc catttgtatc gaaatgctga 1335601 aacgaaggaa aaagtaagat aaataaaaag agtggctcct ttttactaga gccactccat 1335661 ttgtttatac ttgatgtaaa aactttacac aaaccgggta agggacagaa accgttgatg 1335721 ggaggagtgt caatcggccg gtttctttgt ctctttcaaa caagacaagg ttgcctgttt 1335781 cttcatttga agcaacgagg aacccttccg ttgggtcaaa tacaaagtca cgaggccagt 1335841 ttccttctgt cgacactctt tctacgaaag ccagctctcc tgaatattga ttcacttcaa 1335901 atacggcgat actgtcatgg ccgcggtttg cgacataaac aaaacgtccg tcctgcgtga 1335961 catgtattgc gcttccctgg ctgttatctg taaaatcatc agggatggca gaaacgactt 1336021 ggatttctct aaattcgccg gctgtcgggt tgtattcaag cgcaatcact tcattgctta 1336081 attctgtcat gacataagcg tatttttctt tcggatgaaa agcgatatgg cgaggtcctg 1336141 caccgggagc gaaggaatgg cttccggatt cagtcaacac accgtcttta agcttatagg 1336201 tgtagagctt atctatacct aaatcaaccg ctaccacata attgtgttca ggtgtgaacc 1336261 ccgcgtagtg tgtatgcggt ttttcttgtc tttcgtgcgg cccttttcct gtgtgagcgg 1336321 cctctgaaac aggtgattgc aagctgccgt cttcctgaac cggaaaaacg tgtaccttcc 1336381 cgctgtgata attggcagtc agtacgaatt gattttgatc atcaacgctt acgtggcatg 1336441 gcgaagggcc atcaattaac tgatgattca gaaatgtcaa ttcgccgctg tttttatcga 1336501 tttgataggc agcaactccg ccttggccgt ctgctttttc gatggaataa aggatggtgt 1336561 tgtttttatt cgtcgccaca tatgtcgggt tgcccagctt agcggccagc tttggctcgc 1336621 tgagtgcttt tttctcagta tcaagctcaa atgaataaat tccttcgctt ccgccttttg 1336681 tatatgttcc cacatatcct atgtattttg tcatgcgatt tcccccttaa aaatgatgtc 1336741 acctctatat taacgtatct tgataaaata agctgttcaa aacatgaaaa aggggaagat 1336801 tcttcattcg cctcgaatca gcggcattgt gcagcacctg aaggagccgc ctgatttaat 1336861 aatttctgac aggtcaattt cgataatgtg atagcctctt ttcgatagct gttgattgac 1336921 atggcggttg ccagggagac tgatgatcgt tttttttccg attgaaagga cgttggtgcc 1336981 aagcgtaaat tgttcgtcct cgggcacctc aataagatca taacgttttg ccagcatatc 1337041 ggctgcatct ggctcaatgg cctgtgaata aattaacgct tcgctttcag atataatgtt 1337101 aaatacgcag tccaaatgca aaaatttttc atgaagcttc actggaacga tcgtatattc 1337161 aggaagtgcc tcttctagct ggccgatagc tgaaatgtcg gtgcgctggc tgattccgac 1337221 atagacaatg tcatcatcga taatgacgtc tccgccttca atactcgtat caagcatgcg 1337281 ggtgtaagag ataccttggc tgtgaaaaaa atcttttata acggcttctt ctccttggcg 1337341 aatcggttca gtcatgcttg acagaaaggc tttttctccg atgacaaatc ctatgtccct 1337401 agtaaaaacc tgttctggga gtccgtcgcg aacgggcaaa aggacgacct caacgttgtg 1337461 tgacctaagt gcctccacta agcggctgtg ctggtcgtta gcggttttta catgaatatt 1337521 gtcatcttca aaatgttttt gtgtttcgtt tataacatct tttatggtca tgtgctcagg 1337581 tttgcataag atcacttttt gaagtgtgcc gtattccgtt cggcataccg ttttgtgctg 1337641 agatttcggg atggatacgt ccatttgttt ttcctcctaa agtgtgaaga atacatttat 1337701 tattccctca tcatgaaaat cattaaacca ttttaaattt tagacaaatg gaagagaata 1337761 ttgtttaata ggagaatata agtgcattta gctaaaagat cagacatcaa aggggagaaa 1337821 ggtatggaaa caccggaaac aagattttgt aaagagtcaa aggttgtgaa aaccagcagg 1337881 gtgttcccgc ttgacacgaa caaccataat acgctgtttg gcggaaaatt aatgagctac 1337941 atagacgaca ttgcctctat ttcagcggcg cgccattgca gacgtgaaac ggtaacagct 1338001 tcaatggatt ctgtagattt tttaaagccg atcgggcaaa aggattctgt ctgcctagag 1338061 tcatatgtga catgggtcgg cacatcttcc atggaagtat ttgtgaaagt tattaaggag 1338121 catttgatga ctggcgaacg ggaactcgct gccacatcct ttttgacatt tgtcgcatta 1338181 gattcaaatg gcaagccggt gcctgtaccg agggttgtac cggaaacaga agaagaaatc 1338241 atgctgcata atacagctgt acagcgtgct aatgaacgta agaaccgcaa gagacacagc 1338301 caggcgcttg caaatgcgct cggaactgat aagccttggt gaacgttaaa cccaaaacat 1338361 aagttgtttt gggttttttt gtacttttca atggtgatta ttacaatggt tagtccgttt 1338421 ttgctagggg attctataaa aaagcaacaa atgtcatgtt aaattgataa ttttgtgaca 1338481 actttattaa agattcattt tagatatatc ttttattcgt aagatcatgt attttaaaga 1338541 tatattttaa atacatcttt tcgaaaggat tgtttataaa atgttagata acaaaacaat 1338601 cgaaattatt aaaagcactg tacccgtatt gcaacagcat ggagaaacaa tcactggccg 1338661 tttttacgat cggatgtttc aagaccatcc agagcttttg aacattttta atcaaacaaa 1338721 ccaaaagaaa aaaacacagc gaactgcact ggcaaatgcc gttattgcag ctgcggcaaa 1338781 cattgaccaa ttaggaaaca tcattccggt tgtcaaacaa atcggccaca agcaccgcag 1338841 tatcggaatt aagcctgagc actacccaat cgtcggtaaa tatttgctga ttgcgattaa 1338901 agatgtattg ggagacgctg caactcctga cattatgcag gcatgggaaa aagcgtacgg 1338961 agtcattgct gacgcgttca tcggaattga aaaagacatg tatgaacagg ctgaagagca 1339021 agccggcggc tggaaggagt ataagccatt cgttatcgca aaaaaagagc gggaaagcaa 1339081 agaaattaca tccttctatt tgaaaccgga agacagcaag ccgttacctg aattccaagc 1339141 agggcaatat atcagcatca aagtgcggat tcctgattct gaatatacgc atatccgcca 1339201 gtacagcctg tctgatatgc cgggaaaaga ctattatcga atttcagtga agaaagatgg 1339261 tgtcgtgtct tcctacttac acgatgggct gcaggaggga gattcaatag agatcagcgc 1339321 accggcaggg gactttgttt tagatcatgc atcacaaaaa gatctcgttt tgatcagtgc 1339381 cggagttggc attacaccaa tgatcagcat gctgaaaaca tctgtttcca aacagcctga 1339441 acggcaaatt ctgttcattc atgcggcgaa aaacagtgaa tatcatgcat tgcgccatga 1339501 agtagaagaa gcagcaaaac attctgctgt taaaacagca tttgtgtatc gcgagccgac 1339561 agaggaagac cgtgcaggtg atctgcattt tcatgaagga cagattgatc agcaattcct 1339621 caaagaactg attgccaaca cagatgcgga ttactatatt tgcggttcac cgtcgtttat 1339681 tacggcaatg cataagcttg tatcagagct cggatcagcg ccggagtcta tccattacga 1339741 gctattcggc ccgcaattaa gtttggcgca gtccgtttga acacatacat gaaactcttc 1339801 tcctttcaga gaagagtttt ttattgagat ataagaaggc agacaagcgc cggtttctac 1339861 atccggacaa tcacagaccc gctgccattt gtgcatacac ggttttgctg ttcttgcatt 1339921 gttctcagca attcattgtt tacctcaatc gctctaatta gttgcttcat tcttagctcc 1339981 aaaccggcca gcctgtcgat tgtttgctgc tggtagccct cgggttgggg agccaatggc 1340041 agatcaaagg gccaaagggt attcgacttc tgatttttca tattgcgtat tgcgcctcca 1340101 atcggtgtca ctttctatta tgttatgttc aggcgatatg cacgttcgcc tagacactga 1340161 tgcatagagg gcctgccacg gggcacaata ggctcaatat gaccagcgga tggaggtaaa 1340221 gatcggtgtt atggatggta tgggtatttt tactgaagcc agttatcgta ttttcgattg 1340281 catatatttt gtttcggctt gccggtaaaa aagctgtgtc acaaatgaac aattttgacc 1340341 tgcttttgac cttcgcaatc ggaaccatta tcagtgagcc gatccttaca tccaagctgc 1340401 cgatgtcaat ttattatgcg ggtgcttttt tggtgcttta tcttatcatg agcaagctct 1340461 ctttatctaa taaatggcga tggctcctag tcgtgagccc gactgtccta atccgaaacg 1340521 gggatattga tgaacgcggc cttcgtaaag aaaggctgac tgttaatgag ctgctcggaa 1340581 agctgaggga aaagggctat gccgacccgg ctgacattga tcttgctatc attgaagaaa 1340641 cgggagaagt aagcgtcatc ccgaaagagg aagcgagagc ggtgcaggtg cgggatttga 1340701 atatggaagc tgaacggaat tttatcccga ttccgctcat actggatggc gaaatccttg 1340761 atcataattt gaaatatctc caaaaaaacc gatcctggct gtttgagaag cttgaggaaa 1340821 aagggtacag ccccaaactg ctgtcttcga ttatccttgg cacgatgaat gcacgcggtg 1340881 atatatccct tgatttaaat accgctaatg aaccgcagca tgatccttac ttatataaac 1340941 cgggaaataa caattaagat ggctctctct tgtaatgaga gcttttttct tttttaaagg 1341001 gaatttttgt ttggtgtcaa atgtacctag ttaggagggg aactgaacat gaaggactta 1341061 tccataagaa acgacatggc gccaacggtc agtttgctgt attccgcagt ggaagaaaac 1341121 agtctccgtc tggcttccat cgtaagccat atgacacaca gtgaacttta ctataagggg 1341181 cgctgccaaa caaaaaacag cacggctcag cttttgcacc atatcacaaa tgttgatatc 1341241 agatgggtct ggcgtatcaa ggaaaatcgg atcccggacc atattgaaca ggcatacggc 1341301 ccgatgacag atgaaagcgg acggctgcct gaaccggtga atcagccaga cttagatgaa 1341361 ctcctgaaaa gacatcagca tgtagtagag aagctgaaat cggtatgctt cactttaact 1341421 gaaaatgctt tgaaccagcc gctttccttc gaaggtgaca ccgcgacgat acgatgggga 1341481 atttggcata tggcagatca taaccgctat catcaggcac atattgaagc tctcaaaaaa 1341541 gaatggaagc aggatgtggc gaagtatgaa cgctaaaacg aagcttgtga ctgatcgaat 1341601 tcgtttgcgc tgtatggaag atcgggatca agccactttg tttgggctgc tttttaatga 1341661 tcctgacgtc atgacatatt attccggttt aaaagataag aggcaaaccc gcgagtgggt 1341721 caattggaac caacgaaatg aaaaagggta cggcgttagt ctgtggatcg ccgaagataa 1341781 gcggacaggg gagtttttgg ggcaatgcgg catcgttccc cagcagatcg aaaatcaaac 1341841 cgtaatggaa attggctata tgtttgcccg ccgccactgg gggaacggct atgcgcaaga 1341901 agcggctcgg gcctgtctgg actatggctt taacgagcgg cagttcggca aaatggcggc 1341961 tttgattgat ccgggtaaca aagcgtccat acgggtagcg gagaaaatcg gcatgcatta 1342021 cagcaaaacg atcagaaaat ggaataaacc gatcgcggta tatgaaagaa aatcttacaa 1342081 ttgaaagata gagctgagtt tagtatcatg atatcatgta aagttttcta gggttccgca 1342141 tgtcaattga catggactgg tccgagagaa aacacatacg cgtaaataga agcgcgtatg 1342201 cacacggagg gaaaaaagcc cgggagagtc aatctcatgt gagacgactg tccggggttt 1342261 ttttgttttc ggagaatctt aatagataga aaggaatgac tcaaaatgaa atggggattg 1342321 gtcgtgcttg ccgctgtttt cgaggttgtt tgggtgatag gcttaaagca cgctgactca 1342381 gccttaacat ggagcggcac tgccatcggc atcatattca gcttttacct tctaatgaag 1342441 gcgactcaca gtctgcctgt tggtaccgtg tatgccgtct ttaccgggct cggcacagcg 1342501 ggaacagtac ttagtgaaat cgttcttttt catgaaccgg ttggatggcc gaagctattg 1342561 ttaattggcg tgctcttaat cggtgtaatc gggttgaagc ttgtgacaca ggatgagaca 1342621 gaggaaaaag gaggcgaggc ataatgctgc actggatcag tttattgtgc gcgggctgtt 1342681 tagaaatggc cggcgtggcc cttatgaatc aatatgcgaa agaaaaaagc gtgaaatggg 1342741 tgctgttgat cattgttggt tttgccgctt cattttcctt gctgtcgtac gcaatggaaa 1342801 ccactccgat gggaacggct tacgcggtct ggacaggaat tggcaccgcc ggcggggcgc 1342861 ttatcggcat cctcttttac aaggagcaga aagacgccaa acggatcttc tttatcgcgt 1342921 tgattttatg ctcagcagtt ggtttaaaaa ttctgtcata aattgatttt tatcaaatct 1342981 tcagtataat ggataaatag tttagactta caaagataag agggattatt catgaaatca 1343041 tatatgactc agcggttgga cgaataccgt gacggaaatg aggataaagg tcggctcttg 1343101 gtcagctgcc ccgatcagcc gggtatcgtc tctgcagttt ccgcgttttt atttgaacac 1343161 ggtgccaata ttatagaatc aaatcaatat acgacagacc ctgaaggcgg ccggttcttc 1343221 ctgagaatcg aattcgactg cgcaggcatt cgtgaaaaaa aatcatcact tcaggcagcg 1343281 tttgcctctg ttgcggaaaa attcgacatg acatggagct taactttggc gagcgaactg 1343341 aagcgtgtcg ccattttcgt ttcaaaggag ctccactgcc tgcatgagct gatttgggaa 1343401 tggcaaaccg gcaacctgat ggcggagatc gctgttgtca tcagtaacca tgaggaagcg 1343461 agagagctgg ttgagcgcct gaacattcca ttccactata tgaaagcgaa caaagacatc 1343521 agagcggaag tcgaaaagaa gcagcttgaa ctgctggagc agtacgatgt tgatgtgatc 1343581 gtgctcgcac gctatatgca gattctaact cctgattttg tttcggctca tccgaatcgc 1343641 atcatcaata tccaccattc attcctgcca gcttttatcg gtgcgaatcc gtacaaacgg 1343701 gcctacgagc gcggcgtgaa actgatcggt gcgacatctc attatgtgac aaacgatctt 1343761 gatgaagggc cgatcattga acaggatatt gagcgtgtgg accaccgcga taatgcggaa 1343821 gcgctgaaaa acatcggaag aacaattgag cgcagcgtgc ttgcccgtgc tgtgaaatgg 1343881 catttggaag accgtgtcat cgttcatgaa aataaaacaa tcgtctttaa ctagactgca 1343941 agaggcccgc gcaatgcggg ctatttttga tgacaaaaaa ccttgacaag tgtctttttt 1344001 ctttgcataa tataaaaaaa tcattgagcg ttgaagagga ttagtaagca gacctttctg 1344061 tgacagagag caaaatgaat cgctgaaaca ttttgccgca tgaaacctgc cgaacctgcc 1344121 ttggagtcct agggggaaaa cctaggcgca taacctggcg ttacaggaga gcggagcgtg 1344181 cacaagcgcg ttcaatcaag gtggtaccac ggaaacccat ttcgtcctta tgaatcagga 1344241 tgaaatgggt ttttttattg tagaagagcc gcggaggaga ataaatgaaa aaacaaagaa 1344301 tagtagtgaa aataggaagc agttcgctca cgaatagcaa aggaagcatt gatgaggcaa 1344361 aaatcagaga gcatgttcag gcgatttccg tgttaaaaaa agcggggcat gaaatgattc 1344421 tgattacctc gggtgccgta gcggcggggt tttccagcct cggttatcca tcccgtcccg 1344481 ttaccatcaa aggaaaacag gcggcggccg cggtcggaca aacactgtta atgcagcaat 1344541 atatgaatca atttaaacaa tactcactga ctccgggaca aatcctttta acgagaaatg 1344601 atttttcgaa aagagaacgg tatcgaaacg cgtatgctac gataatggaa ttattagagc 1344661 ggggcgtcat tccgattatc aacgagaacg attctacatc tgttgaagaa ttgacattcg 1344721 gagataatga tatgctttct gcgttagtca gcggattgat tcacgcggac cagctcatga 1344781 ttctcactga cattaacgga ctgtatgatg ccaatccaaa tgaaaatcct gaggcgaaac 1344841 gatttgatta tttgccagag atcacgcctg aattgcttgg atatgcaggt tcagctggat 1344901 caaaggtcgg caccggcgga atgaaatcaa agctgttagc cacacaaacc gcgctgtctc 1344961 tgggagtgaa agtattcatt ggaactggca gcggagagca aaaacttgcg gacattttgg 1345021 acggcagggg agacggcact tatatcggag acaaagaact atcttcggtt aacaacacaa 1345081 ggcagtggat tcagttccac tcgccgatat cgggagaaat tatcattgat gcgggtgccg 1345141 aagaggcgat gatccataat ggaagcagcc ttttgcccgc tggagttgtg ggcgtgaacg 1345201 gaagctttcc gaaaggggcg gttgtggaag tcaggggacc gggcggcgtg atcggcaaag 1345261 gccaaactca ttactcctcc gaggagatta tggaggctaa aggcaaacgc agtgacgaac 1345321 ttgattttga gaaaacgttt gaggttattc ataggaatga ctgggtcaat gtaaaagact 1345381 aggaggcgga aaaatgagtg aagtttctgt aaaagcgaag ctggcgaaag aagcagcagc 1345441 cgaaatgatc atgaaaacaa cagccgagaa ggatgaggcg ctcagcctca ttgcaaacgg 1345501 actccgcaaa gaactggatt ttctcttggc ggagaatgca aaagacattg tgaacggaaa 1345561 agagaatggt ttaacaccgg acatcattga ccgtctctca ttggatgaga aacggatacg 1345621 cgatatcgcg gacgcggtgg agctcttaat cgacttagcg gacccaatcg gcgactctct 1345681 tgaaacgatt gaaaaagaaa acggcctgtt tattgaaaaa atccgtgtgc cgctcggtgt 1345741 cgtaggaatg atttatgagg cgaggccaaa cgtcacagtt gatgcggcta ccctttgcct 1345801 gaagacaggg aacgcggttg tgctgcgggg aagctcctca gccatccaca gcaacaaagc 1345861 gctcgtcagt gtcatttaca gagcacttga gcaatcagcg cttccgattc acgctgtgca 1345921 gctgattgag gatacgagca gagagacagc aaaagagctc tttacgttaa atgatggctt 1345981 agacgtattg attccgcgcg gaggcaagaa actgattgat ctcgttgtga gagaatcaac 1346041 agttcctgta ttagaaacgg gagcaggaaa ctgccacata ttcattgacg aaacagccaa 1346101 accgcaaatg gcagaaaagg ttgttgtaaa tgccaaaacg cagcgccctt ctgtatgcaa 1346161 cgcgattgaa tcattgctga ttcacaaggc ttgggcaaga cagcacggaa aagaattgct 1346221 ggaccagctg gaaaacgcgg gagttgaaat tcgcggtgat gaattggtat gtgaacttca 1346281 tccttcaagc aaacaagcat caaaagaaga ttgggaaacc gaatttttag cgcctgtcct 1346341 cagcgtaaag acggttgaaa acgtccaaga agctgtaaag catatccaac aatacggcac 1346401 caatcattct gaagcgattt taactgaaaa tgacaaaaat gcggtatatt ttcaaacggc 1346461 tgtcgatgct gccgctgtct atcataacgc gtcaacccgc tttaccgacg gctttgaatt 1346521 cggctacgga gccgaaatcg gcatcagcac gcaaaagctt catgcaagag gaccgatggg 1346581 gcttcctgca ctgacttcta caaaatacat cattaaagga actgggcaaa tccgtgaata 1346641 gcggggtaat gttcaatgaa aaagcttatc tcattacgag ataagctttt ttatacgcga 1346701 aaaattgaca tttcaaattt aattgtgtac aatttaattg tataaaatat attgggggaa 1346761 tgaaaaatga gtcagccatt atttaccgca actgtttcag cggtaggagg aagagaagga 1346821 aaggtcattt catcagaccg cgttcttgag cttgatgtcg caatgccggg gacaccgaga 1346881 gccaagaaat tagaaaaagc gacaaatcca gagcagctgt ttgcagcagg ttatgcagct 1346941 tgctttgaca gcgccctgca gcttgtcgca agaacagaac gggtaaaagt agagacagag 1347001 gttacagcaa atgttagcct gttaaaggat gaagcggacc agggctataa gctgggtgtg 1347061 acgctgcaag taaaaggaga aggagtcagt gcatcagaat tggaggcgct tgtgaaaaaa 1347121 gcgcacggcg tctgcccgta ctcaaaagca acctccggaa atattgatgt gacacttgaa 1347181 gttgctgaat aaataaaaag aggatgcctg tacaaggcat cctcaatttt tttgatgaag 1347241 tgtttccagt aatgtatata gagcggactt taactgtttg agatcctccc cagactgctt 1347301 tgagagcccc agaattgtcc ctggaatgtc aaccgctttt tcttttaata acgctccgtc 1347361 ctctgtcagg ctgatcaaca cggaccgctc atcctcttca gatctttttc tcgtaatcaa 1347421 accctgttgt tccattcgtt taagcatcgg agtgagcgtt cctgaatcta aatacagctg 1347481 ttcgcccatt tttttgacag taagcgtttc atgttcccat aacaaaagca aagccaaata 1347541 ttgagggtat gttatattca gcttatcaag cagcggcttg tattgctttg tcatctcccg 1347601 cgaactcgca tatagcaaaa aacaaagctg attctccaat ttcatatgat caaatttatt 1347661 ttccattttg ttcaccaact cttttttgtc attcgattct attgtatctg aaaaacctca 1347721 cttttcctat tctcggcaaa catagcatgt ttaaaaagat cagaaaggga aatataacaa 1347781 ctagatacaa ataaggaggt tgggaaatat ggcactattt acagcaaaag taaccgcgcg 1347841 aggcggacga gcaggacata ttacatcaga tgacggtgtt cttgattttg atattgtcat 1347901 gccaaatgcc aaaaaagaag gacaaaccgg cacaaatccg gaacagctct ttgcggcagg 1347961 gtatgctgca tgcttcggcg gcgcgctcga acacgtagcc aaagagcaga atatcgaaat 1348021 tgattcggag attgaagggc aggtcagcct catgaaggat gagagcgacg gcgggtttaa 1348081 aatcggtgtc acacttgttg tgaacacgaa agatttagat cgggaaaagg cacaagagct 1348141 tgtcaacgcc gctcatgaat tctgtcctta ctcaaaggca accagaggaa atgttgatgt 1348201 aaaactagaa ttaaaataat gaccggcatc ctgaggattc tcaggatgtt ttttggtgtc 1348261 ggacatgcgg ggcgggcaca gatttatgat aaaacttcag agaagcgttt gaagcatgcc 1348321 tttaaaccaa aagttacaga tgaagcgggt ggctggcacg gtgtctgccg tgctgaattg 1348381 cgcgtatatg ctgttttgta tttgcacagg gcatagcggc tacttggaga aataacaagg 1348441 accaggccgc gcatgcctga tccttttaat attctttctt attggcgaag ttccgccatg 1348501 cttgaaacgg ggataaatgc tctgttagtg tcacttgata aaaggggatc gttctttctt 1348561 cagcaggttt atcaatttct ttataaatga atgaatcatc aaacccggct tcggcagcgt 1348621 ctgtgtgctc agctgcatag aaaacggctt taggccgggc ccagtagatg gcgcccaagc 1348681 acattgggca tggttcacag ctcgtataca aaatgcagtc atcaagctgg taggctccta 1348741 gcaccttaca ggctttccga atagctgtga cttccgcgtg ggcagtcgga tcattgcttg 1348801 ttgtgacgtt gttctgtccc tctgcaataa tggctccgtc tttcacgata acggctccaa 1348861 aaggcccgcc gattcctgca ttcactcctt cacatgcgag agtgacagcc cgttttaaga 1348921 acgtttcatg attcatccca atccctcctg tcaatagagt gttattagta tagccgaaaa 1348981 gaatgcaaag aacattctta aaaaagtgca aaataaacaa agtatttggg ggatttgcta 1349041 aataagaaac cgattgtggc tgtattatag aaaaaaacca tctgccaaat gcagatggtt 1349101 ttttcaaatt atactagctg tgtctgctgt gctcttgcct gttttgcggc ttcaaccata 1349161 tttttcaatg ctgcaaccgt ttcttcctgc tgtcttgttt tcaatccgca gtctggattt 1349221 acccagaagc ggtcagtcgg acagacggca agcgcatcaa cgataatatt gtacatttct 1349281 tcagttgacg gcacacgagg gctgtgaatg tcatatacac caaggccaag ccctttcaaa 1349341 tacgggtggt tttttaagta atctaaaaat cctccgtggc ttctgctatg ttcgattgta 1349401 atcacatcgg catcaagatc attgattgta tcaacgatat cttcgaagtt gctgtagcac 1349461 atatgtgtat gaatttgtgt ctcgtttttc acggaagaag tggttaatct gaaagcttct 1349521 gccgcccaag tcaaatactc atcccaatcg cgggttttca atggaaggcc ttcacgcagc 1349581 gctggttcat cgacttgaat gatttgaatg cctgcgtctt caagcgcttt aacttctttg 1349641 cgaagggcaa gcccgatttg gaaggcgatt tctttcctcg agatgtcgtt tcgagggaaa 1349701 gaccagttta agattgtaac cgggcccgtc agcattcctt tcacatgctt ggaagtcaat 1349761 gactgtgcgt agactgtgtc tttcactgtc atcggttcaa taaattcaac atctccgtaa 1349821 atgactggcg ggcggacaca gcgtgagccg tatgattgaa cccaggcata tttagtgaag 1349881 gcgaaaccgg ccagcttttc accgaagtat tcgaccatgt ctgtccgttc aaattcgccg 1349941 tgaacaagga catcaagctc caattcttcc tgaatatcaa tccatctttt tgtttccgca 1350001 ttgataaagt tttgatactg ttcatcggac cactcagctt tccgccattt ttggcgtgcg 1350061 ctccgcactt cagcagactg cgggaagctg ccgatcgttg tcgtcggcaa aagcggaagg 1350121 ccgagagatt cattttgtag ggctaaacgt tcttcaaacg gaatcgggcg cttgaagtct 1350181 ttatcagtta attgctcaag ctctttcttt tgttcagaat tggcgcctgt tgcaaactgt 1350241 ttaagcgcct ggatatcagc cttagcctgc tgaatctctt cgctgatcgc cgcttttcct 1350301 gatactaagc cttctttcaa agctgtcagc tcggccagct tttcttttgc gtaggataat 1350361 ccgttcaata ggtctttttc caaatgctca tcagggtgtt tcgctactgg aacatgcagc 1350421 aggctgctgg aaggctgaat ccacagttca tcaacttttg caatgctgag aatatcaaga 1350481 acggcatcga gacgctcttc aaggtccgct ttccaaatgt tgcgtccgtc gataacgccg 1350541 gctgccagca ctttatctgt cgggaagcca tgtgttttaa gctgttccag gtttctgcct 1350601 ttgtcgtgaa cgaaatcaag gccaattccc tgaaccgggt aagagatcag ctcttcataa 1350661 gcatcaacag aatcaaaata cgtctgcaaa agcacattca aggatgaaag ctcacttgta 1350721 atgctttcaa ataattcttt tgcgccgcgt acatcttcac tagaggcggt aacgagcgcc 1350781 ggctcatcga tttgaaccca ttttacgcct tcttcttcaa gctctttcaa aagctgtaca 1350841 tataatggca caaggcgttt ttggatcgct tttgcttcag acggttcata gcctttagca 1350901 agcgtaacga acgtataagg gccgacaatc acaggctttg tttccacacc gtattcctgt 1350961 ttgatccggc gataatcttc gagttgtttg tttcttgtca gacggaactc aatgctctcg 1351021 tcatattccg gaacgatgta atggtaattt gtattaaacc attttgtcat ttcactagat 1351081 acagcgtctt tgattccgcg ggcgatagcg aagtatgtat cggtagcgtc agtcaaatgt 1351141 ctgaaccgtt tcgggatcca gttgaagctg actgctgtgt cgagtacatg gtcatactgt 1351201 gtgaaatcag aaacaggcac aacatcaatc tgctggtcaa tttgtgtttt tactgcggat 1351261 aaaaatagtt cgtcgatttg cttcaaaaac gtatctttat cagtactgcc tttccaatac 1351321 gcttcaagtg cttttttcca ttcccggttc agtccgattc tcggaaatcc taaattcgat 1351381 gttttgatgg ttgtcattgt ttctcctcct ttatatgtaa aacactctct ttcacccgcg 1351441 gatacaggct gctaagaggt tttctcacaa caaaaagcct ctttcccatg agagaaagag 1351501 gcttttctac gtaaaacact gcctctctca tctctcagac acaatctgat ggaattagca 1351561 ccgtgcctta tgagacatca gtctcggcgc gaaaagcagt gcgccccatt tcacaatggt 1351621 attacggtcg gttgctgttg gggtcaaaag gccaatccct cgcccaactc tcgataagag 1351681 aaaatgttat taattttttg aaaagttgaa tcatttgttg gtaatcttaa cagtaattca 1351741 aattcattgt caacatagaa tttgaaattt ttatttacat gatgtggtgt atattatata 1351801 agaaaaataa tcttataggg tcaacaaatg tgattgctct gctttttctg cgagctcatc 1351861 aggagctgtt aaatacagga atccattgcc tgccagcgtt tttgcaatat caagaggaag 1351921 tgtcctgcgg attagctgtg cgaaaacctc agattcagaa agctttcttt gaaatgattc 1351981 ttcttcatag cttttgatta aagcaagcgc accgctgaca tgaggggcag ccattgaagt 1352041 gccggtcagc ttaccgtact tcttgttggg aagggtggat aagatgtttt ctcctggtgc 1352101 cacaaggtca atctctttat tcgcgttaga aaattctgat aattctcgcg ctacagaaac 1352161 agatccaact gcaatcactt cattataagc tgcggggtag gaaagctctt ctgtgcgttc 1352221 gtcgccgtca ccttcatttc ccgctgcaca aacgacaagc actccgtttt tcactgcgtt 1352281 tttcactgct tcttttagct ctggcacatc gcttggccct ccaagggaca ttgagatgat 1352341 gtcgactttc tgttccaccg cgtagttgat gccgttaatt atccattcgt attgtccgct 1352401 gccgttctcg ccgccaagaa ccttcacaat caataggctt gcctcaggcg cgactccggc 1352461 aatgcctccg tttgaatcat tagctgcaat tgttccggcg acgtgtgtgc cgtgtccgtt 1352521 gtagtcggaa atcgcatctt ccttgccgcc gtcgtcatcc gtgaagttct ttccgccgat 1352581 gatttgattt tttaaatcag ggtggcttgt gtcgcagcct gtgtctaata cagcaacttt 1352641 aatatttttg ccttttaccc cttttgccca catttctggc gccttaatca ctttaatgcc 1352701 ctcaggaagc tcgtttacat ccatgatctg ctcattcgtc acatacggga tcaagcggat 1352761 ttcaccattc ataaaaaagc cctccttttt tatgcttgca agtggattca agggtgttgc 1352821 ctcatattat atgaaaaaag caagcgctcg gacagagcca tttgaagcat tttgaaaaaa 1352881 taggatacac accaaagaat tagtaatctt caaaatattg gatggcttca acatgtatga 1352941 ctgggattca actgtaagtc aagttataat agtgttgggg aaaggagcag tgtcatgaaa 1353001 ctgaatgaaa aattatatgc atttttttca gagcatgtgg aacaaatggc cgaggaatgg 1353061 attgaaacga tggaggaaag tgatccgaat tcgctttacg ccctacataa tgcaacagta 1353121 acggaagaat tgaaagagca ggacagagaa ttttaccggc atctgaatta catgtatgtt 1353181 ttaccggaaa aacaatttct cgaagagttt caagagtggg tcattgagct gaccaacgat 1353241 caaaaacatc tcgacacacc ggttcagtat gtcattcggg agtttatgag aaacaggaga 1353301 ttatatacga agtattttga gaagttcgca gaagaaaatg aatcagcgtt tgaaccggga 1353361 gagaagcaaa aatgggcaga tttgattgta aaagtatttg atttcaccat ttatacattc 1353421 gttgatcacg ctgaaatgaa tgccaagcag caattaaacg cccaaagaga aatgatattg 1353481 gaattaagct cacctgtcat taccctgagc aaatcaacag ctctgctgcc gcttgtcggt 1353541 gacattgata ccgaacgggc gaagtttatt ctggaaaaca cgcttcaagc ttgtgcgaaa 1353601 agacgtgtgg agcatctgtt aatcgatctg tcaggtgttg ttgtggtgga tacgatggtg 1353661 gcgcaccaga tctttaaatt gattgaggcg cttaatctga tcggtgtccg gtcaaccctg 1353721 tcaggaatca ggcctgaaat tgcgcaaact gctgtacagc tggggattga cttttcgaat 1353781 attactatta aaaccaacct tgcccaagca ttaaactatc atcaataaaa aaatccgcta 1353841 tctgtgatag cggatttttt atgatgcgaa acataaagat acgagaaagg atcccgcgaa 1353901 taataagagg acgaggcaaa agaacaccca gtcgcgccgg ttcacgctca atgtcctgta 1353961 gtatgtccgg tttctgcttc ctgtaaatcc tttcgattcc atcgcaagcg ctgtccgttc 1354021 cgcttttctg atggcgcttg ccaatagcgg tatggtatat cgttttaacg cactgatttt 1354081 attaatgatg ccgctctccg ccgctcctcc tctgatttta tgagcctgct gaatcagctg 1354141 gacctcatcc tttaacagcg gaagaaagcg aaagcctgca atgacaccgt acgcgagctt 1354201 tggtgagagc ctgcactgct ggacaaggct cagcataaat agaatcggat cggttgtaaa 1354261 aacaaacatc atcgataagg cggaaaagca taaaatacga aacccgagag agatgccgac 1354321 agacacatta tcgctgttaa tggagatagg gcctgcttga aacaaaaaat tatccggtgt 1354381 tgtcggcact tttccaaaaa ctgcggctgt ccacacgcat ccgaatgcta aaatcaaaaa 1354441 cggaatcgta aacaacaacc attttttcaa tgggattccg gccgccagta aaacgcccgc 1354501 aacgatgatg atataaaaac atgccggagt gtaagggttg taaataaacg acagcatgac 1354561 gacacaacaa aaaaccgccg ccgctttcac agtcggatta atgagatgta acggttgctt 1354621 catcacgcac ctcctcttga aatgccatcc attcatatag aaggggaagg gtgagctttg 1354681 ctttttgaac aagccctgtt tcttgagaaa acaactgcgc tggagatccg tcaaaggcca 1354741 ggcctgtatc gtgaagcaca agcacgctgt cagcatacga agagactagc tccatatcgt 1354801 gtgtaatcat aaggacagca gttccctctg ccttgatacg ttgaatcatt tccatgcatt 1354861 cagccgccgt gcgggcatcc tggccaaagg ttggttcgtc taataataaa acctttacgt 1354921 catgcatgag catagtagct acgctcagtc gccgtttttg cccttggctg atcgcaaacg 1354981 gatgatgatc agccaaatgc gcaagaccaa aacgctgcag caggtgttgc gcttttttct 1355041 cagtttcagc atttgctttc tggccgaaca gaagctcgtc atacaccgta tcggtgacga 1355101 attgatgctc agggttttga aaaacaaatc ccatccgttt acgcaattct ttttctttat 1355161 atttctgcag cggctgatca tagagaagga ttttgccgct ttgcggtttc atgagactgg 1355221 ccagaactga taggagcgtc gattttccag ttccgttcgg accgacaagc gccgttaaag 1355281 agccttcgcg caacgaaaag ctgatgtctt tgaaaatcgc ctgctgtcct ctcgcgaacg 1355341 aaaggctgct gacttcaagc acactctccc cagaaggggc tttcttcttt ttgacatgcc 1355401 cggcaggaat aggctctttg aacagcatct cttttgataa agtaaacggc atactcagct 1355461 tttcctgcag atgacagacc tttggaatgg cgatgcccaa tttctttagt gtctccgctt 1355521 catgctgaaa tagatttttc gtcaggccat ccagtgcctt tttgcctgat ttgtcgagta 1355581 cgatcgttct ctcaatccaa ggcgcccatt catcaagctg gtgctcaatg acgaggaggc 1355641 tgaaaccttt ttcccgctga agatccttca tcagatgaac gaactcccga gctgagaaag 1355701 ggtctaaaag agaggtcggc tcatctaaaa taataagctc aggctccatc gccaaaatac 1355761 aggcgagagc cactttctgc ttttgtcctc ctgaaagggt tgagatcatt ttttctttta 1355821 aatgggtaat gcgtaatttt tctaatacgg cgttgatttt ctctgtcatt tcttcttttg 1355881 gaatttgcag attttccagc ccgaacgcta tttcgtcctc caccgtcagc atgcagaact 1355941 gctgatcagg atcctgaaaa acgaccccgg catgctgagt aatcgtttcg gaggtttcag 1356001 catctgtgac cggcttttga aatagaaata catgtccgga ctgaatgccg tcgcaagcct 1356061 ccggatatag accgtttaaa caaagggcga gcgagctttt accgcatccg ctcggtccta 1356121 ataataaaac acattctcct ttttgaagct caaacgaaat gtcttgaaaa accggtttct 1356181 cgtcttcttc ataagagaag ctgagctgct caaccgtcag aagctcatca aaggcttgca 1356241 tgttctgacg cccgcttccg tttctttttc agttcctttc cgagtgccat tccgtttaac 1356301 acacctgtat aagcgagaga gtcgctgaca gcttttccga gaagccccgc caaaagcgcg 1356361 ccggaaatga ggcggatcac aagcataatg agcagataac ctggtgaata ggctgcatag 1356421 ccagaaacaa agagatcata gataaagctg gctactgaag accccatacc ggccagcata 1356481 aggacaggga gagagtatgc tttccagcgt gttgcaagaa atacagcctc agccccgagc 1356541 ccttgaacaa tgccaatgac gatgaccatc gggccagacg gatttcccag caggcactca 1356601 acgagagcgg caatgatttc agaaacgagc gccgcacccg gttttcgaat catgtacgcg 1356661 gcgatcacag aaacgataaa ccaaatgccg taaattggtt cataggcgat tggcccaaac 1356721 atacctgcaa gtacgtttcc gaaatgtgta aataataaat aaacaacggc aaatacgata 1356781 ctgataacgg acatgatgac aatttctttt actttccagc ttttcatgtt atccctgctt 1356841 tctgtttttt cttgatggac tgttagccga aagattcaca gtcatggtga tgtggtttgt 1356901 ttgctgctca gccatgcgga aaacggcctc caatgtgctg aatacgtcat gcgcatcccc 1356961 gtcaagctcg ctcgcgtaat ggacaccctg tacgaaagtg ccttgggctt ttgcaatgtc 1357021 gacagcctcc ataatcaatc ccatataatc cggctcattc attggataaa gggcaaattg 1357081 gcacggcgct tccgccttca agcctcggac agcatcttca ttgacacgct tatcaccttt 1357141 ggaaagatat gtatccccct gtgtgtcacc cgggcatcca atggaaaacg tgccgttcat 1357201 gacgatgtgt tgttcgctgt ttgctgcatg aaggtaaatg gcttttgcag catcgaatac 1357261 atgatcaatc gatccgcgta acaccgtgct gatatggtcg gttttcgtcc aaaccttgga 1357321 tgtatctgtt tttttcagcg cagacttgat cacactgata aaatcatccg tcatcggata 1357381 taaagagaag cgaaaaccgg cgattctgct tgtaccgcaa atatgctcca tttctccgac 1357441 ctcctgtttt tttggtaaaa taaaaaactg catatcctaa gggaatatgc agtcatagat 1357501 cgattaagcg cacaaaaaaa tacaccattc ggtcaacctg cacttcccca cgctggtatt 1357561 atccagatcg ggtcataagg gatcaaagcg cgtttcttcc gcgctttatc tcagccaaaa 1357621 cagcacccct agtgctttcc gtatacaatt ttttattttg acatcataat agatgataag 1357681 aatcattttg taaacaacga aatcattttt ttcatatagg gacgggagag gatggtcaaa 1357741 tttggaaaaa ggacacatat taattgtgga agatgaagaa aaaatcgcca gggttcttca 1357801 gcttgaattg gaatatgaag gatacagcgt cacgatcaaa cacaatggca cagaaggtct 1357861 tgatgcggca gcggaaggcg ggtattcctt ggtgcttctt gatgtcatgc ttccggggct 1357921 tagcggactg gaagtgctgc gccgcttgag aaaaacggat tcgcagacac cggtcatatt 1357981 attaacggcg cgagacagta ttcctgataa ggtaacaggt ctggacatcg gtgcaaatga 1358041 ctatgtcacc aagccgtttg aaatcgagga attgcttgcg agaatcaggg cggcgctgcg 1358101 gcaaaatgga acaaaaactg aagatatcgg cacctttctt acatatgacg atttgcgggt 1358161 gaacgaaaaa acccgtgaag tgagacgcgg agacaaagag gtggaattaa cgccgcggga 1358221 atttgatctg ctcgtctata tgctaaagca tccgcagcaa gtgctgacac gggagcaaat 1358281 tctaagctca gtatggggat ttgattatat cggtgataca aatgtcgtgg acgtctacat 1358341 aagatacatc agaaaaaaac tggactatcc ttacgaaaaa cagctgatcc atacgattcg 1358401 cggggtcggc tatgccatta aggggtaaac gatgaagctg aagaccaaga ttcatctata 1358461 cacttcgata tcactgttga ttttattaat tttggttcat accgcagtat atctcatttt 1358521 ttcgtctgcg ctgacatcaa aggatgcggc ccggcttgct gatgagacgg ataacattgc 1358581 cgaagcgctg cgtgccgctg aaacagaagg agtggctttg caggatatgc tgcaggccta 1358641 tcttccggca aatggcatgg tgcgtgtagt gaatggtgat caaaaagccg ttatgacgat 1358701 cacaaaagaa aaagcctata aagattttcc tctctctttt catagcggcg aaacggcaga 1358761 tgtgaggaaa cctgacggca agctgtttgc cgaggctgct gttccggtga tttggaccga 1358821 tggacaagtc gtgtctcttc agctggttga aagactggag aacacagaag agagtctgtt 1358881 tctgctgaaa atcatcttaa tcgctgcaag tgctgctgtc tgcattgctt ctttttttgc 1358941 aggcagcttg ctagcccgcc gaatcatcaa tccgatcaga cgattaatga tcacaatgaa 1359001 agacatacag cgagacaaag aatttaaaac gatttcttta gaaggacagt ccaacgatga 1359061 attgtatcaa atggggctga catttaatga aatggcaatg atgctgaagg agcactatga 1359121 taaacagcag caatttgttc aagatgcttc acacgaattg aaaaccccgc tcactattat 1359181 agaaagctac agcagcctga tgaagcggtg gggtgcaaaa aagccggagg tgcttgagga 1359241 gtcgatagaa gccattcact cagaagcggt gcatatgaaa aaactgacca atcagctttt 1359301 ggcgctggcc aaaagccatc aaggactcga ggttgatctg aaaacaatcg atctgattaa 1359361 agcggcgcgc gcggttatgc aaacgctcca gtccgtttat cagcgtgaca tattgcttga 1359421 aacagataaa gagagcctgc ttgtaaaggc agatgaagaa cgcatcaagc agctgttgac 1359481 cattttgctt gataatgcaa taaagtatag tgaaaagcct attgagatgt cagccggaac 1359541 gaggaatgga cggccatttc tatcagtgag ggatgaaggc atcggaatac ctgaggagca 1359601 tatcccgcat ttgttcgaac ggttctaccg ggcagatgag gcacgaaaca gaaaaacagg 1359661 cggaacaggt ttaggccttt ccattgccaa gcaaatcgct gatgagcatg gcattgagct 1359721 gtctgtcaaa agcaagccgg gacaaggaac agctgtcacc atgcaattca gcgaacagaa 1359781 tgggggaggc cgatgactaa aacaataaaa acagtatctt ttgctgcagc agccatttta 1359841 gttgtcatca tctgtacgtt tctcatcatt cggcaaaccc atgagaacgt attgtcaaag 1359901 gagactgtcg taaaaaaagt cgaagcctct tatgaaggca aggtcacgaa agcaacacaa 1359961 tcaaaggata aaaaaacata tgatataacc cttgaaaatc caaagggaac ttactttgta 1360021 aaagcagacg caatatcggc tgacattctt tcaatgaata gagtaaaagc agtgaatcca 1360081 tctgccatga cagaaaaaga agccgagcat ctcgcgcttg agcgggtgcc gggaacggtc 1360141 aaaaaacaaa cacggcaaag tcaagttgcc acttatacca tacaaaaaga agacgggaaa 1360201 acatacgaag tgaaggtaga catgcaggca aaaacagtct tgtctgccga tcaaatcagc 1360261 agcaaagatc aacaaaaaac gccgattacg aaaaaagaag ccaaaacaat tgcagagcga 1360321 aaaacgggcg gaacagcgga tgacgcagat ctcgaagaaa gtgagggcac tctcatcttt 1360381 gaagtagacg ttgatcttcc tgataataag gaagcgacag tgaaaatcaa tgcctacaca 1360441 ggaaaggtag ctaacattgt gtatgaagac tgacggtttc tcatcaaatt ctcatcttgc 1360501 tctcgttttc ctttcatgtt gagtatgtaa actgtactca tacaaaacaa aggagggctc 1360561 acaaatgctc aagaaaaaat ggatggtcgg tcttttagca gggtgcctag cggccggagg 1360621 attcagctac aacgcgtttg ccacagaaaa caatgaaaac agacaggctt cttctaagac 1360681 ggatgcactc actgaacaag aagcagaagc aattgctaaa acagttgttg acggcacagt 1360741 agaagacatt gacagagacc tttacaacgg caaagaagtc tatgaagtgg agattgaaaa 1360801 agaaggtgaa gactacgacg tttatgtaga tattcataca aaacaagcgc ttaatgaccc 1360861 gttaaaggag aaagcagaac aagtcgccat aaccaaagaa gaagctgaag aaattgcttt 1360921 aaagcaaaca ggtggaaccg taacagaaag taagcttgac gaagatgacg gtgcttacat 1360981 ctatgaaatg gaaatccaaa cgaagcaagg aactgagaca gaatttgaaa tttccgcaaa 1361041 agatggacgc attatcaaac aggagataga tgactaatca aaacccccgc tgcagcgggg 1361101 gtttttcatg ataagaaacc ttcttttgga caatctaagt agaaaaggag gcgaaacgca 1361161 tggaaaagaa agaggagcaa tacatcaatc aggctgaata tgtccctcat ccgacgaagg 1361221 aaggagagta tgccttattt cttcatgaaa cgtatcattt gctttctgaa gatgacgaga 1361281 cacaaacaac agaataaggg cttaggccct tgttttgttc cgtaattgtg atgtaagcgc 1361341 atttattact tttttgagtt gacatagctt gtttttttct gtaatctcag tgtgtcaatt 1361401 caattaggaa cttcgttagg tgaggctcct gtatggagat acgctgctgc ccaaaaatgt 1361461 ccaaagacgc caatgggtca acagaaatca tcgacataag gtgattttta atgcagctgg 1361521 atgcttgtcc tatgccatac agtgctaaag ctctacgatt gaaggcgccc gcacgctttt 1361581 tttgccgtgc ttctttcacc ttcaatcccg aaggcttttt ttatgccttt aaaacgaaac 1361641 caatcaaagg aggtgcggag tatggattct ccccattcga gtcaatctga agaagtaccc 1361701 atatactatg acagcaagac aattgattac acgatgagga gacgaactgc cgcaccttct 1361761 ggcgaggccg gcacgtctcc gtagaggagg tacgagtccc gatggttcaa aacatgacct 1361821 atgacgaact cattttacgc atcattattt tactgcgaga cgggaaaatc agggatttta 1361881 gaagtgttat tgatgagctt cagccctatg acatggcatt tatttttaaa gaaatgccgg 1361941 aaaaacatcg cgcccgctat ttatcttatt taactgtaga cgatatcact gatatgatcg 1362001 gggagctgga acgcgaattt cagcttgtcg tcttaaataa agtcggaaaa acaaaagcaa 1362061 cactggcgat gaacaaaatg gacaacgatg acctcgctca attgcttgaa gaaatggacg 1362121 aagaactgaa ggaacagctt ttatccagca tggaagcgtc agaatcaaaa gctgtacagc 1362181 tcttgatgaa ttacccggct gattcagcgg gacgcatgat gacaaaccgg tatgtgtgga 1362241 tccctcagca ttacacggta aaagacgcgg tcgtcaaact gaaaagcttc gctgaaatag 1362301 ctgaatcgat caactactta tatgttatta atgaaagcaa acagctggtt ggggttcttt 1362361 cctaccgcga tttgattctg ggtgaacctg aagaaaaggt gcaggattta atgtttaccc 1362421 gcgtcatatc agcagatgct cttcaggacc aggaagaagt tgcccgcctg atagaacgtt 1362481 acgatttttt ggcaataccg gttgtagaag aaaacaacgt gcttgtcggc attgtgacgg 1362541 ttgatgatat tatcgacgtt gttattcggg aagctgatga ggattacgaa aaatttgccg 1362601 cttccggtaa agacatcacc tttgacacaa aagcttacgt ggcggcatac cggcgtctgc 1362661 catggctgat tttactctta tttatcggac tgatttcagg aagcattatc agctattttg 1362721 aagacgcgct gaagcaggtt gtcgcgcttg cgtttttcat gccgatggtg tcagggatga 1362781 caggaaatac gggaacacaa tctcttgcgg ttgtcatcag aggtttgtct aaagaagaaa 1362841 tgaacaaaaa aacgattgtg cgcctgatct tccgggagtt cagaacaagc atttttatcg 1362901 gagcggtttg ttctgtgctg attgcgattg tttctatcat atggcagggg aatgcgcttt 1362961 tgggatttgt tgtcgcctct tcactgttct taaccttaat catcggcacg atgtcaggaa 1363021 cgattatccc tattattttg cacaaactga aagtagaccc ggcgattgct tctggaccgc 1363081 tgattacaac gttaaacgat attttatctt tattaatcta ctttggcatt gccactgcat 1363141 tcattcactc attataaacg taaaaagtcc gtctcaactg cgagccggac ttttattatt 1363201 taacggtttt tgtaccgaaa gtgagcatta agctgcccct ccagcatttt tttccgcact 1363261 tgcggatcgt tttttaacat ctgttctttt ttgcgcatat cctttaaaat ctctgccgtc 1363321 tgtacgccgt cttcacgctt attggcgata tccatcagcc gctccacatc ggcaaaggag 1363381 tattttcttg tcccccttga agaacgctgc gggtaaatga gctttcgttc ctcataatac 1363441 ctgatctgtc ttacggacaa tcctgtcaat tcactcacaa ttccgattga aatcactttt 1363501 ttgtctttat aagaatgatc ttctgtggtc atttttccac ccctggatgt cttttgataa 1363561 tagtatataa aaaacaaaga gaaaaaacct gacgcttgtc atattttcta acatcaaata 1363621 gaagattttt gaaaaaatac ggaagaaaaa ttaacaagaa taatgcgtaa cacccaagcg 1363681 cgttttatcc tttatgtaac gaatcaaacg aggaggaagg ataatcatgg aggaagaaaa 1363741 agcagtctca ctggcaaaag aaattataga gttggatatc aagcgtgatg aaatgctgga 1363801 gacgtttatg cagcttgccg gagaacaggc ttttcaatta ttaagatcgg ttcaaaacgg 1363861 acaataccga aaatcttcgt aaacataaat tctttacatt agattcatac cacgttcatt 1363921 taaaaagagt atcttttgta taggatacct caaaatgaag gaggacgcta tgagtaattt 1363981 attgaaatcc gctttagaaa aagaacgacg ccattattct gaaaaactct atcagatagg 1364041 ggtttataat aaagaggtca tgaacaaaat gacgatttct gagcttcgga aagaatacgc 1364101 ttatttcttt cgaagcatta caaatcataa aaattatcct tatacaagat aatgtataag 1364161 gatttttttg cttttagaag gaatttctcg aattatagcg aatacgtata gtaagggact 1364221 gaactcttat tatatgtaag ggttttcatt atttttttat aaaaatccta tatacgaggt 1364281 agatatgatg agattatcgt ttaacgaaga agaagttgag cgtgcgatga atttgtacag 1364341 agtttttgca agggctttca aaagtgtgtc cgaacatagt atccgtgata gcaaagagca 1364401 cggttttaat cccactgaat ttgctgtact ggaactcctg tacacaagag gcccgcaaaa 1364461 attacagcaa attgggtcga gacttctgct tgtaagcgga aacgtcacat atgttattga 1364521 caaactagaa agaaacgggt ttttagtaag ggagcaggac ccgaaagata aacgctctgt 1364581 ttacgcacat ttaactgaca agggaaatga gtatttggat aaaatttatc cgattcatgc 1364641 actgcgtatt gcgagagcgt tttcaggtct ttcgcctgat gaacaggacc agctgatcgt 1364701 cctgctcaag aaagcaggca tacacagcca gcatttgctg tttcgttaac tattctacac 1364761 tctctatttc aggagagtgt ttttttgttt ccatatgatt ctttttaaaa catctttaat 1364821 cttcctatca gacatttcgc caaggtatcc attgacgtgt tttttatact ccttcatctg 1364881 ttcgttcgat tgaaaaaatg ccgcgatata ctcttctgct ttctgcatgt cccagtttct 1364941 catatctgtg acgagtttcc tttcatgtag aaggtttaaa ttcatttcct cctgtcccgg 1365001 cagtgcatga taaataaata ccggaagccg tttctgtaag cattcactga tggtcacgcc 1365061 tccgggttta gtcatgatgc ctgtcgcctg ttcgtacaaa cggttcatct ctgctttgct 1365121 gtgaaggtaa ggaatcgcct caatcaaggg gtggtgtaaa cttttgacat aggagtagag 1365181 cttttcgttt ctgccgcata atattttgta taagatcttt ccgcctggcg acagttcctg 1365241 cacccatttt aaaatcccac cgacccccat actgccccct gtgatgatga tggtatatgg 1365301 cgggtggtgc tgcaaggtat ctgctgattc catttcaaaa ttttggtgaa ctggaatgcc 1365361 ggtcaagtat atgttgttct gatcgatacc ctctgatatt agctgcttct ttacttccgt 1365421 gctcggaaca aaatggtaat caatgttctt ccgtccccat aattgattca cgaaaaaatc 1365481 agtgtataca ttcacaaccg tcagattcgg atattcaggc tttagtcggt tcagcagata 1365541 agaaggcagc gcatgtgtgc agaaggcgat atcaggctgt ttttcttgga ggatgtgcct 1365601 catttgctgt gtgaacagcc attcgtacat gaaatagcgt ttgtcatgct gaaattctcc 1365661 gcaggcgagg agcctgtaaa tgccgctgta cgttttcggg aaatattgaa tccattttaa 1365721 ataagccacg gaggacaatt tttctaaccg cctatacgaa tgtgaaaaga tatcaatctt 1365781 ttcagctgcc agcccttgag actctaattc agcctgcaat gcatcagcca catgatgatg 1365841 gccggtggaa atgcttaaaa aaggaaaaat gagaatgttt ttcatgacag tcctcctaaa 1365901 aaaatatggc aactatattt tgaggagaac gttcacaaaa tataagggtg tttttgatca 1365961 taaggaaggt gaaaagatga aaacttgttt cctttccata tggagagtgg ttgatccgat 1366021 ttatttcttt ttttcaaggc taagcttgat tgacaacgat caaaaaagcg tttttcgagt 1366081 caggctgacg aagtacaaag gacatcatgt cgtgcttagc gacggaacgc atataagaaa 1366141 aaatgatgtg ctcgttaaaa tccacctgca taacataaag ctgatcaggg agctgcaaag 1366201 cattgagagc gcagtcagaa agggaatcat tatttatcag aaagtatatc aatcgatgcc 1366261 gcttcttctt gactatatca acaatcataa aaaaagcgag aaaatcaaag gaatcattgg 1366321 gattacaatg cttgacaaag gtgtggaaag gctcggcttt gatgtgatca ccccggtgaa 1366381 ccctttttac agatgcttta aaaaagtgtc tcatgtgccg attttatatt tgacttcaaa 1366441 gcctgtgagc ttgcggcatt taccgaattc atcctatttg tttatctcaa aagaaaagct 1366501 gcagaaaacc tatcaaaaaa aagactgatg cctcggtcag cacagtcttt tttgattaaa 1366561 tctgatgaaa tgtcacttca gggcggcttc cgacacggat atttacgccg gtttgtccca 1366621 agccctcgct gatataaaat ggtttatcgt gatgataatg aaggccttta atcatgttca 1366681 ttcgcacgag ctttcccatt ttcaccaaat gatacggttt tggccagtga atttgcccgc 1366741 cgtgaaaatg ccctgacagc aggtaatcat aatgaacatc tttcatatcc agaataatat 1366801 ttgggtcatg tgttaagaca agatgatagc cattttccag actttgataa gagccggtga 1366861 tattactccg attcgtactg taatcatcaa tgccgataat attgactggt cctgcagccg 1366921 tctcgattcg aacatgttca ttttgcagcg tgatacagcc gttttcctct aaaactcgct 1366981 tcaatctctg aaagtcctct tctttcaata cataatcgtg gttaccgaac accgcgtaca 1367041 ttccatatgc aggctttagc ttttgcaagg cgttcaagta acctgccagt ttcggaatat 1367101 tacgtttccg atcaagaaaa tccccggtaa gagcaatgat gtccacaggc tgatcttttg 1367161 ttaaatgata cagctcctca ggtgagactg aaatgttttc caagtgaaga tcagataaat 1367221 gaaggatatt taattttttt ctggctggaa ggccgtcttt ttggtcgatt gaaatggtgt 1367281 tgactttcac atcttttgta ttgcggttcg ctttatatag aaatggcaca aatacgagta 1367341 tggccaatga aagtaagatt gtaaacaaaa tatatcccct cccttctatc agtatagtaa 1367401 gtgatcaagc cctatggata gcgggaatta atgggtagag acaggttgaa aaacggattg 1367461 tcatatgatg aatgatttgg aagggaaaag ggataataaa ttttgacaca tgaggcagaa 1367521 catgccgacg gagtcagaat aacaaatgga tgtgtaagca atgttacgat tgatgagaca 1367581 acaaaaaaaa gaaacatatt atctctggat cgcattattt cttcttttat tgtatgtatc 1367641 cccgcttttt attttaaagg aagatgccca tatccgggtc cacgataatt tagattccaa 1367701 catcgcttgg tacaaggttc tggccgatag cggagaaatc gtcggcaagg ttgacgctgc 1367761 cattccgcaa atcattaacg ggctgccccg ggatgccttt ggcaccgagt ggagcggaat 1367821 tgtttggctc catgctttct tttcttccat gaccgcctat gcaataagcc agacggttac 1367881 aagagttgtc gctttttttg gaatgtatgt gctgctgaag aaacatataa tcccggaacc 1367941 aaaagcggct ttcatccgaa ttggcgtatc gcttgcattt gccttaacac cgttctggcc 1368001 ttcgggaatg ctgagtacgc ttgggtaccc tttggcactg tgggcttttt taaatatccg 1368061 aaaaggggat atctcatgga gagagtggct gacgctgggc ttgctccctc tatactcaag 1368121 ctttgttcta ggcttcttct ttttcctggc agggatggcg tgtttttggc tgtatgatgc 1368181 cattacaaaa agaagatgga atttgatgtt cttaggcagt attgcattta tgacgagtat 1368241 ctatcttttc gttgaatatc ggcttgtcta ttcgatgctg tttgagcacg caccgatgca 1368301 tcgtatcgaa tttatctcat ctaggcatga cgtttggcat tctcttcgac tatccataaa 1368361 aaactttgtc tatggccata atcatgtgat gaccgttcat accgttgtca tccttccgat 1368421 cctgatggtc gtatttgctg ctctgctgtt caaacgaaat cggacaaagc cagaaaatgt 1368481 ttatctgttt ttatgtgtgc ttaattacgg gttgtcatta tggtatgcgt tttggttcaa 1368541 caaaatttgg gctgttccaa agcagaaatt tgctttttta gcagaattta attttgcccg 1368601 ttttcatttt cttcggccgc ttgttatata cgtgagcttt gcgcttgctt tatatctcat 1368661 ttggcggatg gggaaaggat ggaaatggct tgtgtacgcc gcagtcgctg cacagctgat 1368721 ggtgttggcg ccttttaatg aagaatatac gtatggtgtt cattacaacg cgccgacatt 1368781 cagggagttt tatgcatcag agcaattcaa agagattaag gaatatatcg gacgtccgca 1368841 agattcgtat agggtggcga gcatcggact gcatccgtct atcgcccaat ataacgggtt 1368901 ttatacgtta gatacgtata acaatctgta tccgctctca tataaatatg aatttagaaa 1368961 aatcatcgaa aaagagctgg aaaaaaattc tcggctgaaa caatactttg atgaatgggg 1369021 cagccgctgc tacctttttg tcgatgaact cggtaaacga tatgatttca aaaagaactc 1369081 gaagaaaacg atcaacaacc ttcaattaaa tacagatgta tttaaaaaaa tgggtggacg 1369141 gtacattttt tcttcagttc cgatcatgaa tgctgaacaa aaccatctcg cgctcgtaaa 1369201 gacgtttgac cataaagatt ccgcctggcg catttattta tatgaaacaa gataaggagg 1369261 atatcgattg aaacagtcac agccagtatt aaccatcgtc gtcccgtgtt tcaatgaaga 1369321 ggaagtgttt caagaaacaa gccatcagct gacagaggtt gtagatgatt taattgaaga 1369381 aaaattaatt gctgaagaca gtaaaattct gtttgtcgat gatggcagca aagaccgcac 1369441 ttgggctttg attgctatgg agagcataag aaacaagaag gttaccggct taaaattagc 1369501 ctgcaatgtc ggccaccaaa aagcgctttt agccggattg cataaagcga agaataggtc 1369561 agactgcgtc atttcgatcg atgctgatct tcaggacgac atctctgtga tccgggattt 1369621 tatgctgaaa tatcatgagg gctgcgagat cgtttacggt gtacgccgga gcagaaaaac 1369681 cgataccttt ttcaagcgca cgaccgcgtt agggttttat cgtctcatga ataaacttgg 1369741 gattaaatta atttataatc atgctgattt tcgtttaatg aataaaaggt cccttgaaga 1369801 gcttgagcgt tatccggaag cgaatctgtt tttaagaggt attgtcccca tgatcggctt 1369861 taaatcggcc gaagttttgt atgaccgcaa ggaacgcttt gccggcaaaa cgaaatatcc 1369921 gctgaaaaag atgctatcct tcgcttttaa cgggattact tcattcagtg tcgcaccaat 1369981 tcgattcttt acgcttttag ggtttgtttt gtttttcctc agcgctgtgg cagggattgg 1370041 cgcgtttatt caaaagctgc tcggccatac gaatgcaggc tgggcgtctc ttatcatatc 1370101 catttggttt ttgggcgggc tgcaattgat gggaattgga atcatcggag agtatattgg 1370161 aacgattttt tctgaagtga aaagacggcc gaaatacgcg attgatattg atttgtataa 1370221 tgaacagctg agcccgcttc agcgccagga aaaagagcgg ttagaaaaaa agtacagtta 1370281 aacacggaaa gagctgactt cattagtcag ctctttttct tcaactgatg caatatagcg 1370341 ctaagcggtt cgtcttgcgg gttgcggtaa aaatcaaaaa atgggcagcc ctgcttctta 1370401 attcgatcga tgaccgtatc aattgtaaac agagcgggtg ttaaagatga ttgcacctca 1370461 tgccagtaga gcggggctgc aacagtccca agctcatttc ctctcgttga atagggacag 1370521 ataatcgttt ttccttctgc atgctgcaaa taatcaagat acaatttgca gtgtctgttt 1370581 ttaatcaagc gttcagtggt aaagagctcg ggaaatgcat tggtgcagta ctctgcgatc 1370641 agctgcgtaa attggcgtgt ttcttcatac gtaaatgcct cgggagacaa gggaatataa 1370701 agctggatgc ctttgttgcc ggacagcttc gggtacgatg tgatgccaaa ggaatccaac 1370761 agccgcttca gttcatttgc ggcctgcacg gccataagaa agtcatctcg cgaaggcggg 1370821 tctaaatcaa tgacaatctc agccggacgc ctgcttttaa tggtttgaaa aggaacgtga 1370881 aactccaaag caagctggtt gcaaagccat agcaatgtag acatatcctc acagacaata 1370941 tgttcatggc ttccatcata gaaagactga acaaaatccg gcgcatagtc cggcttgttt 1371001 ttttggaaaa atgattcgct cctagatcca tgcggatagc ggatgacggt gacagcccgg 1371061 tttttcagaa atgggagcag gtagtcactg acttcaatca tatactgaat aaaatcttct 1371121 tttgtttttt tattcttttc aaatatgatt ttatccaggc ttgtgaactg gagctttggg 1371181 tgaaccggtt tggagtgtcg tatgacttgc gcatacgtgc attcggtcca gtccatttgg 1371241 aattcgaaac cgataaacga tacctctctt aatgtgcctt ggagaattgt taagtattga 1371301 acagctgcac aaatcgaagg ttcaagcgta aattcgcctg agggtgtttg atgtccgtgc 1371361 tgttccataa tctcgcgtat agcgcttttt tcctcatcac gcattccgtg cgagacagag 1371421 gcaatcggtg tcattattcc gttttttaac accgataccg tcagaaaccc gttgttaggg 1371481 ttgaaccctg ttatgcaaac ataagcttgt ttaaagtttt tatatttgag ccaatcggac 1371541 gaccgcttct tttcaagcca tttgctgttt gttttcttcg ctacaattcc ttctccgtca 1371601 tattttatta ccatctccca gagttgatca aaatgatcat aacagggaat ggattgaatg 1371661 gtttcttttg cgtaaggatc tggagatgca ggaagctttg ctgcggatat gagttcacgc 1371721 agcgattttt tgcggtccaa atacgaaaga agcgttacat cttctccgct tcgctctaac 1371781 aaatcaaagg cgagaaagca gcacggccgc gcgtttgccg attcctgaat cttgtctggc 1371841 cttttcaaac gcccccgcac ttgaaggtgt tcaaaatctg cacgacaggg attcaccaaa 1371901 catacgattt caccgtcaag tgtcagcgga agctcttttt ctaggtgctg aaaggcagtt 1371961 ttggcgaatt gtgtgatttc agggaaggtg ctgctgagct ccacaccatt tctgctggtt 1372021 aaggtcacac ctgaagaatg gatgcggaga atacagcggt acccatcata ttttacttcg 1372081 taacgccatt ctgctccgat tggcggtgac gaagttaaga ccggctgcat ggtaaacgcc 1372141 atgcgctatg atgtgccgga ggcttttttt ctagttgttt tttgtttttt atctccggct 1372201 cctttcggtt cagcggcttg tgcaggtgcg gcagccggtg tctcccggtt cggccttctg 1372261 gttctgtcga tgctggcttg cagagcgctt accaggtcaa tgacatcttc acgaggtggc 1372321 gctttatcag gagtgacagc cgtttcttta ttttctagct tgtcgttgac tctttgcagc 1372381 agcgcctgtc ggtacgtgtc ttcatatttc tcaggctcaa acttagcagt cagttcatct 1372441 attaatgtga tagcagtttg cagttcctta tcgtttacat tcgattgatc aggtacacct 1372501 gggacttgag cggcgcttct gacctcatcg ggataatgga tagactccat gacgatacaa 1372561 ttttcataaa cgcggagaat cgccagctgc tgctttgacc tgattgtcat attggcgata 1372621 ccgatctttc cggttgagcg cagcgcctca cgcagcaggg tataggcctt cgtcccatta 1372681 tccccggggc cgacaaagta ggagcggtta aaataaatcg gatcaatttc ctgaagctga 1372741 acaaagtcaa caatctcaac tgctttctcc tcatgctcct gttttaagct ttttaaatct 1372801 tcgtctgtca gcactacata ttttcctttt acatattcat atcccttcac aatttcatca 1372861 ggactaagag ttttttcgca atttgtgcaa actttctcgt atttgattgg tgcgtgatcc 1372921 tctttatgga ggctgcgcag tttaatatct ttatcttctg tggccgcata tagcttgatg 1372981 gggatgttta ctaatccgaa gctgatcgat cccttccaca ttgtatgcat atcgataaac 1373041 cccttttttt ctttagtgtg aagagaagga gtacgattca tgtgtagtaa cttatgggtg 1373101 aaaaaaagcc ggcgctgtta ttgcgacggc tgttcaataa tgaattgttc gaattgttcc 1373161 ggaggtattg gcctgctgaa aaagaagccc tgcaaatggt cgcagccttt ttcaaaaaga 1373221 agctgctttt gagctgcatt ttccacacct tcggcaatca cctgcaaaga cagctgatgc 1373281 cccatggcaa taatagctcc ggtaatttgc tctgatttag gatgggtctg aatatcgtca 1373341 ataaatgatt tgtcaatctt cagcctgtga atcgggaagt ccttcaaata gctaagagag 1373401 ctgtgaccag taccgaaatc gtcaatactg attctgattc ctaattctgt tagggatgac 1373461 aaaacctttt tggagtgatt gagattgtcc attgtcatgc tttccgtcac ctccacttca 1373521 agaagctgcg gaggaagctg gtacttatta agcgtatcct tgatgagggg aatcagatct 1373581 ttagattgaa actgtctggc ggaaatatta atggcgacag aaagatcata gcctttgtca 1373641 tgccaaatcc ttgcctgctt gcatgcttca tctataatcc actttccgat atcaataata 1373701 agtcccgttt cttctgcaac accgatgaat tctccgggcg gacgcagttg cccgtctggt 1373761 gtcacaaggc gtatcagtgc ttctgctcct gtcatttttt gttttttcac actgaattgc 1373821 ggctgataat gcaagacaaa tctatcgttt tcgattgctt ctctgagtac catctcttgg 1373881 ttaagcttaa cggtttcttt gttgccgatt gaaaaagaat agtatctgta tttgcttttg 1373941 tttcgttctt tagccgcata catcgccata tcagcctttt tcatcaattc aaggccatcc 1374001 gtcccgtctt ttggagatat cgcaatcccg atactgacag atgtgacaag ggtgtgatct 1374061 tgaattttga aaggtttttt gaatttttgg ataatttttc ttgctaaaac atctgcttcg 1374121 cctgttcctg tattggcgtc tgttaatata ataataaatt catcaccgcc aagacgggcg 1374181 ataaatccgt tatcagggac tacagatgac aggcgtttag ctgcaaactg aagcaattga 1374241 tcaccgacat tatgccctaa tgcatcgtta atcactttaa accggtttaa gtcaagaaag 1374301 aatacaacag tgttataatg caaggaatgc tcgcgattca gcacctttgt tagatgagag 1374361 atggcatgcc ttctgttagg taagtctgta agcgaatcat aatgagccat tctatggatt 1374421 tctttttctg ctttgtactg cttcgtcatg tctttacaaa tgacataaat gctgtctagt 1374481 tcctgattga cctcaacagg tataagcgta atatttaagt gaaactggcc tttttcagtg 1374541 ataagatcgc tatcgctgtt catcgcttgt ttatcttttt taacttgctc aaaaaggcgc 1374601 ttaaccttca gtgatgtgta attcctccag tcatgcatgc tgaagccaaa tttgctgatc 1374661 atttcctcac cagcgtgatt ggaagatatt atgtctcctt ctaatgataa aataaaaatt 1374721 gcatcaatat tgtggacgat taaagactga aatcgctgtt cgttatcctt tatgcgttcg 1374781 ctctgtttaa taaactttcg atctgcatgg gaactgaata acaataacgt ttggatacaa 1374841 aaaataatta aagtaacaaa aattgaccaa tgaaacgttt gcacctccat atggcttccg 1374901 ggcggagcca tgtccttatg gaaagttgcc gcaagcatcc ctgtgtagtg catgcccgaa 1374961 atcccaatgc ccattacaat tgaactgacg cctttataga atataagatg ctcagaatgt 1375021 ttttttacgg ccaagtcaaa gaatattttt aacgagacga aagaggctgc aatcgcaatg 1375081 ataattgaaa ctgtaaataa aataggttcg taaataatca ttacccggga aatggcagac 1375141 attccgatat agtgcataga agcaatagat gcgccaagca caactgatcc ggtaagcagt 1375201 ctgtaatatg taagaatgtg ccggctgaca aaatataatg acacaaatga tcccgaaaca 1375261 gatgcgccaa tggctgccat taaaggcatg aattcatatt ccatcggcat ttccatatgg 1375321 acggccatca tccctacaaa atgcattgac caaataccga atcccataat aagtgagccg 1375381 ccgatcagcc aaattttact ttttaagcct gtattgatgg tgactttcct tgaaagttca 1375441 agggaaatat acgaggcggt acaggcaatt agaatagata aacatatgag agtcgtatta 1375501 tatgtaacgt gtatttccaa atggagattc cccccgtatc gtgtgttcca gtcttgttga 1375561 ctctctttat tatcggctgc ttaaccgcag agtttcagcc ttcaaaacga tagaaatacg 1375621 agggagatct atttttagtt caactgaccg tgaaaaatgt gttaaaatca tcttgatgtt 1375681 ttccgaaaag agaaaaatgt atgatacata aacatgaaac aagggagttg gtggctatcg 1375741 aagagctggt tatgtcatgg attgaagcat ttaaaagctt atcttatttt ggaatatttc 1375801 tagcgctcag cattgagttt attccggccg aagtcgtctt gccgcttgcg ggctattggg 1375861 tatctaaagg cgatatgaca cttgctggcg ttgttttggc aggatcgctt ggaggagtgg 1375921 ccggtccgct tacgctgtat tggataggcc ggtacggagg aaggccgttt cttgaacgtt 1375981 ttgggaagta tctctttatt aaacctgaag cgcttgataa gtcagataat tttttcaaaa 1376041 aacatggggg ctttgtcgcc ttcagcggcc gtttcttgcc tggtatcagg acattgattt 1376101 ccataccgtg cggaattgca aaaatgaatg tttgggtgtt ttcgctttat acattcattg 1376161 ctatgcttcc gattacattt gtatatgttt atctcggtgt gaagctcggt gaaaattgga 1376221 aggcagtcgg ctctattctt gatcaatata tgcttccgat cgggatagcg attttggcgc 1376281 tgttcctgct ctacttactg atgaaaaaga ggaagaaacg cacgcactcc gaacaattat 1376341 ctgtattttt gaaaaataaa cgttgacaaa tcactgcgct gcgcatatta ttgacgtata 1376401 aaatcatatt tcttgaaatc ccaaagggga gtagcgtccg gaatgtattc cggaaacaaa 1376461 gtcgtcattt catggattgt atccatcggc tttgttggca tgcctgaatt catgtctagc 1376521 aagacctttg ccttatgtcg gcaaaggtct tttttgcatg gtccggccgg cataagatcg 1376581 gatgaagaga aagaaaacaa cttttttggg agggtatcat ttatggatgc agcattatta 1376641 ttagagtatg gttgggttct tctcgtcttg atcgggctgg aagggatttt agccgccgat 1376701 aacgcgctgg ttatggcggt aatggtaaaa catttgccgg aggaaaaaag aaaaaaagcg 1376761 ttattttatg gattggcagg ggcttttgtt ctgcgatttg gctctttatt tgcaatttct 1376821 ttcttggtca acgtatggca ggttcaagcg attggcgcga tctatttgct gtatatctca 1376881 gcaagccact tattgaaaag atatgtattt aagaaagaag acacacataa agagacgaag 1376941 caaagcggtt tttggccgac tgttttaaaa gttgaactgg cagatatcgc gtttgctgtt 1377001 gattccatct tagcagcagt agcgctggcg gttacacttc ctgggacatc actcccgaag 1377061 atcggcggac ttgacggagg acaatttctc gtcattttgg ccggcggtat catcggactg 1377121 gtgatcatgc ggtttgcggc ttccatgttt gtgaagttat taaaggaacg tccaagccta 1377181 gaaacagcag cctttgtgat tgtcggctgg gtcggagtga agcttgcttt atatacgctt 1377241 gcccatcgcg acatagcggt tgtttctgag cactttatcc attctggaac atggaagctg 1377301 atattctggg gtgtcttagc agcaatcgcg gtttgcggct ggtttatgtc aggtgggaaa 1377361 aaacagccgg agggtgcaca aaacgaacaa aaaaacagca cccgtgaacg ggcgtaatct 1377421 gaaagactct gcttaaaagc agagtctttt tgtgtttgaa gcgttttcat aagcgaaata 1377481 aaataacatt tttataacat ctttgttaca aaaaacacgc ataaaacccc cttaattctt 1377541 tagaaaggca cgaaatcatg tatagaacgt cagaatggtt tgtcataatt gagacattgg 1377601 aaatcaatat ttctttttct cctttgcgaa tccctatcaa attagctatc attaatgagt 1377661 agttataggg aggaactgag gtgaaaccag tgcttagcct tttgtttaaa ttgggaaaaa 1377721 agaagcaaac acttgaaaaa gctgttgaga gtatacaaaa aggcaataaa gatctgcaaa 1377781 atgaattaat acagcaatat aagccattta tcgcaaagac ggtttcatcc gtttgtaaac 1377841 gatatataga tgaaaaagac gatgagttca gtattggact gatcgcgttt aatgaagcta 1377901 tagaaaaata ttcacctgaa aaaggaaatt ctctgctcgc atttgctgag cttattataa 1377961 aaagaaaagt cattgattac attagaaaag aagccagaag cgcacaaaat ataaatatcg 1378021 atttacagga aggagacgat caggagtcat cacaaagcct gattgaagcc gagctttcca 1378081 ttgatgaata ccgccgtcag attgaacagg agcagaggcg ggaggaaatc ctctattttc 1378141 aaaagcagct caaggattat ggtttatcgt ttaaagaact gcttgaaaat tctccaaaac 1378201 acacggatgc aaggcaaaac gccataaagg tggcaatgac gcttgttgaa catgaagaat 1378261 tggccgctat cctgtataca aagaagcagc ttccggtcaa acagcttgaa cagcttgtct 1378321 ctgtaagccg aaaaacgatt gagagaaaca gaaaatatat tattgcgatg tgtattatca 1378381 ttacgggtga ttatatttat ttaaaagatt atcttaaagg ggtgctgcac tcatgagaag 1378441 agggattata gtagagaaaa ataaaaaatt cgtcacgttg ctgacccctg acggacaatt 1378501 tttaaaagcc aaaaatgatc gacacagcta tgaaatcgga gaagaaatca tgcttccgag 1378561 tgaaacacgc atgggcagaa gggccagctt ttttgatttt tttaaactgc gccctttcaa 1378621 aatggggatt tttacgatga ctgctattat gctctttatt tttatagttc tccccgtttt 1378681 ttctaataat aaggcctatg cgtatatgac aatcgatatc aatccaagcg tcgaaatggc 1378741 gttaaacagc gattatgaag tgattgaact gacgcctcta aacgatgagg gacagaaagt 1378801 cgtgaatgat atagatgatt gggagaagac tgattttaaa aaggtgattg acgatattat 1378861 aaccgactgc agtgaacacg ggtatgtaaa aaaatcgaaa gaaatattga tttccactgt 1378921 ttatgaaaac acagaagaca atacatataa aaaggctgtg aaaaaacagc tgaatgatgt 1378981 gactgaaaaa tataaaacga cataccgcat ggaatctctc gagtcagata tgcaaacgag 1379041 ggaaaaagcg aagaaagaag gcgtctcaac aggcagctac atcaaatcaa atgaaaagaa 1379101 tgacaataaa gatataaaag atgactccag caaaccatcc ggggaagagg atcaaaagag 1379161 tgatgaaaat gaggatgaaa acaccgatca aactgacacc caggacagca agcaaggaga 1379221 taatgaacag ctgaatgatg cggattccgg agaccagaaa gaagagaaag cggatgacca 1379281 gattgatgat agtgacaaag ataaaaaaat aaaggaatca gatgaaaaca caaataccga 1379341 aaaagatggg gaccatgagc aaaccccaat acaagatcct caagataaag gaaatgaaaa 1379401 taacggcgct gacaagggcc aaagccaata tcacagggac tggaacaatg gtgaacaagg 1379461 caagaaccgt tcttcgtcca gaagggataa cgcttcagac cgacgtaatc caaacggcta 1379521 cagcagtgat aatcattcag ctaaaaatga agattcgccg agtgcccccg gcgaataaag 1379581 acctgaattt atttagttgt gccatttaat tgtgattgtg cttgctgtac cagccgcttt 1379641 gtcatttctc cgcctacaga gccgttagcg cgtgcgactg tatcagaacc aaggttcaca 1379701 ccgaattctt gagccacttc gagtttaaat tggtctagtg cctgctccac ccctggaaca 1379761 acgagtttat ttctgctcgc catctttttc atctcctttt tcgataaaga aattcttaac 1379821 gcgtatttag tttgaaatat acggggttta tttatgctgg caattgttgt ggagaaaaat 1379881 aaaaccccgg cctctgagcc ggggtggcgc agactataga atgtctgctg tcattttatg 1379941 tgcggttgcc tgaatatgga atgtcaaaat ggagaggact gtaatggcga taatctgtct 1380001 gattttaagc cattggctgt cattcagttc ttcaaaacgg tgacggagac gctctgtctc 1380061 ctgttcggcg atctcctgca gatttgattc tttcatagaa ggagtatctt ggtgatggat 1380121 ggcatcaagc acatatgcgc agctttcata ataagcaatc gggctgatga catcatcaga 1380181 tctgtctgag attgtgttaa aggccacttt taaaatagcc cgtatgtgtt caaagtcata 1380241 aatggatttt aaatcacgta caattaaaag aataactgcc tgttcaattg agtatttttt 1380301 gcccagctca gggtgtccga tcagatcttt gatatcacgc tttacccagt tttgaatcgc 1380361 ggttgacttt aacgaagtca gctcgcataa gttgccaagc tctacgattt catttgtaga 1380421 cagaccgtat tcttttttct gtttttttcg ttcgtatctt gtaagaaatt caggaatttc 1380481 tagatgattg gctgcttttt ctgctgacat gttcgctgat tggacgagaa tgtcgagcgg 1380541 gctatgttct ccttgtcctt ttagggaata gagcagccgc accatatcgg ttcgagagag 1380601 tttaaaaatg ttcattgttc acctctttaa acaatttgac gcggatatag gtctatgtat 1380661 aagttcaaaa ttcaagcgtc agcaaattac attaacatca tacgtcgaat tccttgcatt 1380721 ttcaaatgga tgttttataa tttaaatata cgggttcttt tgaacttaaa ataacggagg 1380781 ttgttatggc gaaaagaatt tttctgttta ttctaacgaa tattttggtg cttacaacaa 1380841 tcgggatcgt tttgtctgtt ttaagctctg ttacaggagt cgggacgtac tttacagctg 1380901 atggcggtat cgatccaatg gcgcttcttg tgttcagttt agtcgttgga tttgtcggtt 1380961 cctttacgtc tcttgcgata tccagatgga tggcaaagac gatgatgggc gtcagagtgc 1381021 tgaatccgaa aaaacactcg ctcagctatg aggaacagca attggttgat cgtgttcaca 1381081 gattaagccg ctctgccggt ttaacgaaaa tgccggaagt cgggatttac cgttcacctg 1381141 aagtaaacgc gtttgcgact ggaccgtcaa aacgccgttc acttgtcgca gtatcgtcag 1381201 ggctgctgga gcagatggat gacgcagcag ttgaaggtgt gcttgcccac gaggtcgcgc 1381261 atatcacaaa tggtgatatg gtaacaatga cgcttttaca aggtatcgtt aatacctttg 1381321 tcgtcttttt atcgcgtatc gccgcttgga tagcaagccg ttttgtcaaa gaagatctag 1381381 cgccgatcgt tcattttatt gcaatgatta tttttcagat tgtcttttcg atacttggca 1381441 gcctggttgt gtttgcgtat tcacgccatc gtgaattcca tgctgacagg ggaggagcgg 1381501 atcttgccgg caaggacaag atgattcatg cgctgcggac gcttaaaagc tattcttccc 1381561 ggattttgga agacgatcag acagctgtcc aaacgttaaa gattaatggc aagaagcgct 1381621 cttcactttt ctctactcat cctgatttag atgagcgaat cagacggctg gaagctaaat 1381681 aatacaaaca cattgttcct ctgagagaat tctcagaggt tttttatttt atccattgac 1381741 taaaatcata aaaaaataag caagttaaga aaatgtttcg taaaagcctt taaaaatgga 1381801 cctaatatct ttagaataat taccgtactt aaaaagagag gcagaaggat tttacatgag 1381861 attaaagttt ggaaaattga tacaggcctt gtcaccggcc cagctgatcg cattatatta 1381921 ttttcttgca gttactgtgg ccgttatatt gctgagtttg ccggcggccc ataaaccggg 1381981 ggcggattgg acgtttattg atgcgctttt tacagctgtc agttcagtca gtgtaacggg 1382041 gctgacagtt gttgatacag ctgatacatt cagcacaata gggattttta tattagcatt 1382101 tgttctgcaa tttggcggaa tcggaattat gacgctcgga acgttcattt ggctgatcat 1382161 gggaaaacga atcgggctga aagaacggaa gctgattatg gttgatcaaa accaatccca 1382221 gttttcagga attgtcaatc tgatgaagca ggtactgttt ctgatcttgt ggattgaatt 1382281 ttttggcggg ctgatactcg gcacatattt cttaacctac tatgactcct atcaggaagc 1382341 ctatttacac ggattttttg ccagtatcag tgcaacgaca aacggcggat ttgatattac 1382401 cggtaattcg atgattccat ttcgccacga ttactttgtg cagtttatta caatgctttt 1382461 aattatattt ggagcgattg gatttcccgt gcttgttgaa gtaaaggatt tcctgttttc 1382521 aaagcatcgg cgttatccat ttacgctttt tacaaagatc acgacgatta cgttcggctc 1382581 acttgtcttg tttggagcca ttggcatctt tgccctggaa gcaaaccatg cgttcgcagg 1382641 aaaatcatgg catgatattt tgtttttgtc cctgtttcaa tcaacggcaa cccgaagcgg 1382701 ggggctggca acaatcgata tcagccaatt atcagattcc acactctttt ttatttgtgc 1382761 gctgatgttt attggagcgt cgccaagctc agtcggggga ggcataagga caacgacttt 1382821 tgctttgaac cttcttgcgc tgtttcattt tgcccgcggc aataaggccg taaaggtatt 1382881 caaacgggag cttcaccctg ctgacttgat gaagtcgctt gttgtcacga tgatggcgat 1382941 cctgctcgtt tttggcgcga cactcattct gaccattaca gaaaaacatt ccctgctgga 1383001 gcttttgttt gaagtgtgct cggcattcgg tacaaccggc ctatcgcttg gaattacggc 1383061 agatttgagc agtgttggaa aatgcgtcat tatgattgtc atgtttatcg ggcgaatcgg 1383121 catcttgacc ttcctgtatc tgatcggaag aaaggaaatt gaagcgaatt atcactatcc 1383181 gaaggaaaga gtgattatcg gataggcaaa acaccgcata ttttgcggtg ttttttgatt 1383241 accaaaaaaa agatgtgtgc ctcctgttca gttggagaac ctaactccga caggtgcaat 1383301 ttacgctcct gcatcttaaa atgtctgaaa attggcgagg aggattcgta tgaagcgtaa 1383361 agctgaagtg aatgaagcca ttaaaaataa caatacacct accgagagca tggaccccaa 1383421 ttcatataag acacaatatc atgacgaccc caattttaga ggggcaaacc gcaattccaa 1383481 acagggccag cagggaggca tgtaattgtg aagaaaaacc gtcatagcag agacatgcaa 1383541 aatcataaaa agcctatgaa taaaaaggtg ctggaggaag aattctcaag tgaactcggg 1383601 gattacaatg ccggaaagat catcgaaacg ctggaagtca ccaagcctga aaagaaaaaa 1383661 gaaaaaaaca aaaaacaaca ataaaaaaga cctcttaggc ggcgtcccgc ttaagaggtg 1383721 ctttttctat tttaaataag catttttgcc cgttcctctg acaaattgca ataagcttgt 1383781 catcctcagc tcaatgaatg gctgagcgac tgtcttaaca aagttgctgg agaggactga 1383841 tgtcagggct gctgttaaaa gcaagaggat cactaagctt tgatagtcag taagccaatc 1383901 ctcaagcccg acctgccgta atgtcttaat aataaacccg tgaagcagat acacgtaaaa 1383961 tgtccgggtt ccccatttgg taaagaaata ccgtttttgc ggaacgagcg ctaaaaagct 1384021 gaaggttgcc ccaaaggcga gtacatacca gccgattcgg gatagtccgc ttaccagggt 1384081 aacgtctcca aatgaagaat acggttttga accaaacaga aaagaatagt caaaatcgat 1384141 gccccagcag atgacgaata ctgcggcaag cactccgagc gcaatttgtt tgccgcgttt 1384201 tgatctcaat aaatcaaaat gatgtttatt taaataaaaa ccgacaagga acatcggtaa 1384261 gaatacgaat gtccgtgaca agctcagcgt gctgctgaca aagtccagat aaccgatcag 1384321 cacggcgatt ccgcagctga caaacagcgc ccactgcttt gaaagctttg aaaaaggata 1384381 taggagcagg ttccaaaaga ataagcttac aagaaaccat aacgaccatt gcggatcaat 1384441 cgggttcaca tttgccatgc tttcatcttg cataatgtaa taaaagacgg aataaataat 1384501 ttggaaaatc aaatacggaa taatcagctt gaccgccagc ttttttacat atcccgcccg 1384561 tttaaagcct ttcgcgaaat aaccggatac aagaataaat gcaggcatat ggaatgtgta 1384621 aatgaacttg tagaggtaga gcataaaatg attatcatta ataaaggaac gaaggatatg 1384681 accgaataca acaaggaata tcaataaaaa ttttgcgtta tcgaaataac tgtcccgcga 1384741 tttactcata gcatcacctt ctctttcatc agtcactaag agattattcc ctgctggtac 1384801 atattttaaa ataaaagatg aaaaaggaat ctaaaaaaat gctgattgtt aggtcgatgt 1384861 aaagtgacgg taaggatcgt agaaaatgtc ttcgtaatgt aatgacgctg aaattttctg 1384921 aaatttatag ggcaaatgaa ggaagttccc gcattttgta gaaatattga gggataggtt 1384981 ttgaagaagg agtgtacatg catggaaact cttggtgtcc agacaaactc ggagctgcga 1385041 gaggaactga atcgcctcaa agaagaaaac gcgcgactga aaaaggaatt gaatcagcat 1385101 caagtgattg tcaacaatac gctcgatgct atttttattt gtgataacga aatgcggatt 1385161 gttcaggcaa atgaagcaac agaaaggatg cttcaagttg actcggaaga tttgaaaaag 1385221 cgttctgttt tggatttttt gttttcaatc ccaaaggatg aactgaatct ttccgtaaag 1385281 aagtttttta aaaaaggctt tctgtggaag gaggttccga tcaggcttga ttgcggggca 1385341 acaaaataca tagagtttct ggccaaaaga ggtattggtg aggatttctt ttttgttgtc 1385401 atgagggaca tatcttctaa gaagattctg gagcgggaat tctctatgaa tgaacagctt 1385461 tttaaggact tgtttgacag agcagttgac ggaatcgtcc tgtttgataa agatggcggt 1385521 tttattgatg caaatttgtc cttttgtaaa agctttgaaa tcaatcataa tgagctgtct 1385581 catttatctt tgtatgagtt catagacagc ggctcacgaa aagatttcga caatatctgg 1385641 aaggcgctca accgcaaggg aaaagcgaag ggggagctgc ctgtcaagct tcgttcagga 1385701 gttcaaaaac tatttgaatt cacgattaca tcaaacatca tcagcggttt ttatatgtcc 1385761 attatgaggg atatcacaga gaagcggtct atggagctgc agctctttaa aagtgaggag 1385821 cgcttcagag aaatctttga aaatgcaatg gacgccatca tcatctggtc gaatgacgga 1385881 agaatcgtaa aagcgaatca atcagcctgt aaaatttttg agctgccgat gaatttgctg 1385941 ttgaaaagaa agctgtgtga ttttctcgtt gactcgcagc agaaatacag cataacgaag 1386001 aggaaatacg caaaatacgg agagatcaga gaagagctgc tgtttcaaat ggggaacggc 1386061 caattcaaag agcttgaatt tacttcaaaa cggacaatcc ttgaaaatca gcatttgacg 1386121 atcttaagaa atgtaagcga cagaaagcgg atggaaaagg agcttcggga aagcgagctg 1386181 aaattcagaa aagtgttcaa cggatcaatg gacggcaatg tattgttcga caatcaatac 1386241 aggatcatcg acgccaaccc gttagcaagc catattttgg gcctgtcaca tgaagagatc 1386301 aaacagcaca gcctgttaga tattatttct gcttatgaaa tagaaaattt ggcatcaccg 1386361 gcaaggcaga ttaattttga tgaaatggac aacgaaattc catttttgct gagcagcggt 1386421 gataacagaa aactcgaatt ctcatttaaa cggaatatta ttcaaaatat gaacttggct 1386481 atctttaaag acgtaacaga gcgaaaagaa ttggaggagc gcctgcgcaa atcagatacc 1386541 cttcatgttg tcggcgaact cgcagccggt attgctcatg aaatcagaaa tccgatgact 1386601 gctcttaaag gcttcattca gcttctgaaa gggagtgtcg agggagacta cgccctttac 1386661 ttcaacgtga tcacctcaga actaaagcgc atcgaatcca tcatcaccga attcttgatt 1386721 ttagccaagc cccaggccat tatgtatgag gaaaaacatg ttacccaaat tatgagggac 1386781 acgatagacc ttctaaatgc gcaagccaat ctcagcaatg tacaaatgca acttgattta 1386841 attgacgaca ttcccccgat ttactgtgaa ccgaatcagc tgaaacaggt ttttatcaat 1386901 atattaaaaa acgccatcga agtgatgcct gacggcggaa atatttttgt aacgataaag 1386961 gcattggatc aagatcatgt tctaatctcc ttaaaagacg agggaatcgg aatgacagaa 1387021 gataaattaa agcgacttgg tgaaccgttt tatacgacaa aggaacgggg aactggactt 1387081 gggcttatgg taagctataa aattattgaa gaacatcaag gcgagattat ggtagaaagt 1387141 gaagaaggga agggcaccgt tttccatatt acgcttcctg tcagacagaa tgctgaagaa 1387201 agaaggaatg atgaatgaac tactatacga cagccgaaac gccgctcggt gaacttatca 1387261 ttgccgaaga ggaggaccgg atcactcgtc tatttctcag tcaggaagat tgggtggatt 1387321 ggaaagaaac ggttcagaat actgagcata aggaaacacc taatcttgca gaagcgaaac 1387381 aacagcttca agaatatttc gcaggcgaaa ggaagacatt ctccctgccg ctcagccaaa 1387441 agggcactcc ttttcagcaa aaagtgtggc aagcgctgga gaggattcca tatggcgaat 1387501 cccgaagcta tgcggatatt gccgctgctg tcggcagtcc gaaagcggtg cgcgctgtcg 1387561 ggcaggctaa taaacgtaac gacctgccga tttttgtccc gtgccacaga gtgatcggca 1387621 aaaacagtgc gttaacagga tacgccggaa gcaaaacgga gatcaaagca tttttgctaa 1387681 acatcgagcg aatctcctat aaagaaaaat aaaacatatg gcacgttccc ttttttcacg 1387741 gccgacatat cattttatta agttaaaaaa gttggtctga tgaaaaagga ggacaaagca 1387801 attgaagccg agccgctctg agaaacttgc cgtttttgcc gaactgtttg tgaaactgca 1387861 tatcttatca agcgctcaaa aagatgaaat catcaatgtt aacaaaaaga aacaaaaaaa 1387921 ccgctgactc ggctccaaat gagcaaagtc cagcggtttt ttaatgcacc ttttctcctt 1387981 taaacagctg ttcaatctct tcttcatagt ttccggtcat aatccctttt tctgtgatga 1388041 ttcctgaaat gagatcatga ggtgtaatgt cgaaagcggg attaaagaca ggcacattgg 1388101 atggagcggt ccgaactccg gaaatctgcc tgacttcctc gggatctcgt tcctctatcg 1388161 ggatatcagc gccgcatttg acctttgtat caaatgtaga taaaggtgcg gcgacaaaaa 1388221 acggaatatc aaaggcgttt gctaaaatag caagaccgta tgtgccgatt ttatttgccg 1388281 tatcaccgtt ctttgcaatt cggtcggctc cgacgataac agcggaaatt tgtttttcct 1388341 tcatcgtatg ggcggccatg ctgtctgtga tcagagtgac atcaatgccc ccctgcatca 1388401 gctcccaagc agtaaggcgt gaaccttgca ggacaggcct tgtttcacag gcataaatgt 1388461 gtaatcccaa atctttttgt ttggccaagt aaaacggagc tagcgccgtt ccatagcggc 1388521 ttgtcgcgat tgagccggca ttgcagatcg tcatgatcct gtcgcctttt ttgaaaagct 1388581 gcagggcgtt ttggccgatc aaccggcacg tttcctcatc ctcgacctga atctgaatgg 1388641 cttcatggac aaggtttgtt tttgcttcat ttacggaaat cgcgttttcg accgaatgac 1388701 tcagtctctc aagcgcccat gacaaattaa tggcggtagg ccgtgagctg tttaaatatt 1388761 gtttgatgtc ttccagtctg cggcggaatt ccgtgacatt gtctgtttca atgtctttgg 1388821 cagcaagcgc cagtccgaag gcagctgtaa tgccgatcgc cggagcgccc cttactttga 1388881 gcgtgacaat cgcatcaaat acatcctctt tcgtcgtcag ctccaaatat tccgtctcat 1388941 caggaagctt ttgctgattt aaaatggtaa tagctgtttc tttccattca acagaacgtg 1389001 gaacagcaaa tgaatgggtc atgaatagat cattccttta caagtaactt aaataattca 1389061 ataacatctg ttatcgtttt gaattccgaa cgtttttcga taaaggctgt gccggtttcg 1389121 agcgccaagc gttttctgcc gattcgttta tcaaacggca cgatcgtatc caggtcagct 1389181 acatgggcaa ggccgatcgt gcgtcgtatc agctcacagc ccgcaaatcc gattgcttct 1389241 tcaaaaatat ggctgagcgt atcagtgagg taaccgtcga tgttggcgta aacatccaga 1389301 ctgtccttct gccaggcttc actaaacgtc tcttcaaacg tttcccagac ctggttgaca 1389361 tgttcatata acggctctct gtcagccccg tcacggctga gtgcgttcaa aaataagttg 1389421 gcgataaatt gccctacatc aaagccgatc ggtccgtaaa aagcaaactc aggatcaatc 1389481 acctttgttt cgtgctcact tgcgaaaatg cttcctgtat gcaaatcacc atgaatcaac 1389541 gtttctgcag acgttaaaaa tgactttttc agcttagcgg cttcgatttt aacgctgtca 1389601 ttattccaaa gcttttcgac aaaaggacga agctcttctt caaaatcatt tgtgtcatgg 1389661 tcgaagaaag gatctgtaaa aacaagtctt tccgtaatgt cgcatagctc tggatttgta 1389721 aactgtttaa caagctgttt tttcacctta ggttcaagcg cgtaatctga tgagtagaaa 1389781 agtgtttttc ctaaaaattc accgatgtgc tgcgacagat gaggatagtt ttcaccctca 1389841 atgagtcctt ttcttgcgat cttgaggtga gagagatcct ccatgacggt aaccgccatt 1389901 tccgtatcag aataaaacac tcttggaacc aggtgaggca catgctcgcc ctgacggatg 1389961 agagcgctgc tttcgattct tgcacggtcg attgtcagcg gccagctttc tcccaccact 1390021 tttgcatacg gaaccgcctg tttaatgatc aatgctctgt catgttcttg atcataaata 1390081 tgaaaaacgt aatttaagtt gccgtctccg atctcctggc atgtcagcgt gcttttgctt 1390141 ggaaataggc caagcttcac cgccaacgcc acagcggagc tttcatttaa cgtttcgtat 1390201 aaaggtgttt ttgtgactcc catcatcata acctccaatt atgtaattaa ttaatatgtg 1390261 gccgtaaaaa agcctccttc tcagagagaa ggaggcttaa catctatgtc cgcctctctt 1390321 atctctcaga tcagatctga atggaattag caccgtgcct taagagacca gcgtctcggc 1390381 gcgaaaaaaa tgcgccccat ttcacaatgg aattacggtc ggttgctttt ggggtcaaaa 1390441 ggccaaatcc ctcgcccaac tctcgataag agaatatatt cacttgtttg acaattctaa 1390501 tttatcagtt gatgaacatg gtaacaggta atttagttag ttgtcaatat attttttaat 1390561 ataaatcttt tctgatatca tcgaaaacag gaatgctctc ccgaacttct gcgctttctt 1390621 gaaggtcgat ttccgctcgg actatgcctt cttcccggcc gccttcagca agtacacgtc 1390681 cccatggatc aataatcagg ctatgtcctg caaattcatt atccggattt gaaccggtac 1390741 aattgcaggc tgcgacaaag cattggtttt caatggcccg cgcaataagc aggcttttcc 1390801 aatgatcaag gcggggaaga ggccattccg cagaaataaa cagcacgttg gcgccttttg 1390861 tcgtatgttt tctgatccat tccggaaaac ggatatcgta acagatcaat ccagagcttt 1390921 tgacgccgtc aagctcaaag tatccgtctt cggaaccggc tgataaatac agatgctcat 1390981 ccatcagctg aaaaagatgg gcttttctgt actctttaat gatttgccct tccttatccg 1391041 cgatgtacat tgtattataa acatcagaat tcttcctgac agcgaccgat ccggcgacaa 1391101 tatgaacacc atgttttttt gccgttttct tcagccagct ctgagcggag cggccgtctt 1391161 cgtcagcgag ttcatcaaga ttggccagat catatccggt cgtccataat tcaggcagaa 1391221 caagaacatc agcatgtttg ctttcttttt cgatgaaaaa ttcagccttt tttatatttt 1391281 ccgaaggttt tccgtatgaa atatcaaatt gaagacaaga tatcgtccat ttcatctttt 1391341 taacacccca aatttttctt tacttttttc atttaaccat atatgatgat ggactatcat 1391401 ttcaagattt ttttagaagg tgagaataga tgaaatttga acagtctcat gtattgaagg 1391461 aattgcctaa acaattcttc gcttctctgg tgcagaaagt gaaccgaaag cttgcagaag 1391521 gacatgacgt tatcaatctg ggacagggaa atccagatca gccgactcct gagcatattg 1391581 ttgaggagat gaaacgagct gtcgctgatc ctgagaatca taaatattcg tcttttcgcg 1391641 gctcataccg tctgaagtca gcggctgctg cattttacaa aagagaatac ggcattgatc 1391701 tggatccgga aaccgaagtc gctgtattat tcggcggaaa agccggtcta gtcgagctcc 1391761 cgcaatgctt gttgaatccc ggtgatacga ttttagttcc cgatccgggt tatcctgatt 1391821 actggtcggg tgtcacactt gcaaaagcaa agatggaaat gatgccgctc gtaaaggaca 1391881 gagcgtttct ccctgattac agcagcataa ccgctgaaat aagggaacag gcgaaattga 1391941 tgtatttgaa ttatccgaat aatccgactg gagctgttgc tacttccgag ttctttgaag 1392001 ataccgtgcg ttttgcggct gaaaacggaa tctgcgtcgt tcacgatttt gcttacggcg 1392061 ctgtaggatt tgacggctgc aagcctttaa gctttttgca gactgaaggt gcgaaggata 1392121 tcggaattga aatttacacg ctgtcaaaaa cgtataatat ggcaggatgg cgggttggct 1392181 ttgccgtcgg aaacgcttcg gtcattgaag cgatcaatct ttatcaagac catatgtttg 1392241 tcagtctttt cagagcgact caggaggctg cagcagaggc actgttagcc gatcagacgt 1392301 gtgtggcaga gcaaaatgcc aggtatgaga gcaggagaaa cgcttggatc acggcatgcc 1392361 gggaaatcgg ctgggatgta acagctcccg caggttcttt ttttgcatgg ctgcctgtgc 1392421 ctgaaggcta tacttctgag cagttctcag atcttttgct ggaaaaagcg aatgtggcag 1392481 ttgcggctgg aaacggcttc ggtgaatatg gcgagggcta cgtcagagtc ggacttttaa 1392541 caagtgaaga aagacttaag gaagccgctt atcgaattgg caaactgaac ctgtttaccc 1392601 aaaaaagcat tgacaagacc ttataacgat gggataattc aaaataattt ataaaatcta 1392661 tattttctta tcaagagcag gcagagggac gagcccgatg aagcccggca accgacttat 1392721 aaagcacggt gctaattctt gcagctagcg gctgagagat aagattcgga cgagaaacga 1392781 aacctcttta gacgcgattg cagtttgaag aggttttttg atatggatga aaatgaaagg 1392841 agctctggca tgagtgagtt attagcgaca tatctcctga ccgaaccggg agccgataca 1392901 gagaagaaag cagaacaaat cgcaacagga ttgacagtag gctcctggac tgatctgccc 1392961 cttgtaaaac aggagcaaat gcaaaagcac aaggggcggg tgataaaagt tgaggagaga 1393021 gagggaactg ctgcatcaga aaaacaagcg gtcatcacaa ttgcctatcc tgaaatcaat 1393081 ttctctcagg atattccggc tttgctgaca acagtgtttg gcaagctgtc cctggacgga 1393141 aaaatcaaat taatcgatct tcacttctct gaagcattta agcgtgcact gccgggaccg 1393201 aagtttggcg tatacggcat ccggaagctg ctgggagagt ttgagagacc gctgttaatg 1393261 agcatattta aaggcgtaat cggaagggac ctgagtgata ttaaagaaca gctccggcag 1393321 caggcgcttg gcggagttga cttgattaaa gacgatgaaa ttttctttga gactggtcta 1393381 gcgccttttg aaacaagaat tgcagaagga aagcaaatat tgaaagaaac gtatgaacaa 1393441 accggacata aaacgctgta tgcggtgaat ttgaccggac gtacggctga tctgaaagac 1393501 aaagcgagac gcgccgccga attgggagcg gatgcgcttt tgtttaatgt cttcgcttac 1393561 ggcttggacg ttatgcaagg ccttgcagaa gatcctgaaa tcccagttcc gattatggcg 1393621 catccagcag tgagcggagc gtttacgtct tctccgtttt acggtttttc tcacgctctt 1393681 ttactcggaa aattaaaccg atattgcggt gctgacttca gcctctttcc gtctccatat 1393741 ggttcggttg cgcttccaag agcagatgca ctggcgattc atgaagaatg tgtgagagag 1393801 gatgctttta accaaacatt tgctgttccg tcagcaggca ttcatcccgg catggttccg 1393861 ctattaatgc gtgatttcgg catagaccac attattaacg ccggaggagg cgtacatgga 1393921 catccgaacg gtgcccaagg cggggggcga gcgttcagag ctattattga tgcggtccta 1393981 gaggcccagc cgattgatga aaaagccgaa caatgcaagg atcttaagct tgcgctagat 1394041 aaatggggaa aggctgaagc cgtatgacga ctcgaaaacc ttttattatt tgtgattttg 1394101 acggaacaat cacgatgaac gacaacatta taaatatcat gaaaacattt gctcccccag 1394161 agtggatggc attaaaagac ggcgtacttt ccaaaacgct gtcaatcaag gaaggtgtcg 1394221 ggcggatgtt cggccttctg cccagcagtt taaaagaaga gattacaagt tttgtattgg 1394281 aagatgcaaa aatcagggaa ggctttcggg aatttgtagc atttatcaat gagcacgaga 1394341 ttccgtttta tgtcataagc ggtggaatgg acttttttgt atatcctttg cttgaaggca 1394401 ttgtggagaa agaccgcatt tattgcaacc atgcttcatt tgacaatgac tatatccata 1394461 ttgactggcc tcattcctgc aagggcacat gcagcaatca atgcgggtgc tgtaagccgt 1394521 cggtcatcca tgaactttct gaaccgaacc aatatatcat catgatcggt gattcggtta 1394581 cagatgtgga ggcagcaaag ctgtctgacc tatgctttgc aagggattat ttattaaacg 1394641 aatgccggga gcaaaacctc aatcatcttc cgtatcaaga tttttatgag atcagaaagg 1394701 aaattgagaa tgtaaaggag gtacaggaat ggctgcaaaa caagaacgct ggcgagagct 1394761 cgctgaagta aaacgggaat tggcagagag agattggttt ccggcgacta gcggcaatct 1394821 gtcaattaag gttacagatg agcctttaac atttctcgtc actgcaagcg gaaaagataa 1394881 acgcaaagag acggttgaag attttctgct ggtcgatcaa aacggagagc ctgctgaaag 1394941 cgggcattct ctgaaaccgt cagcagaaac gcttttgcat acacatttgt acaataaaac 1395001 caatgccgga tgctgcctgc atgtccatac ggtaaacaat aatgtgattt cagagttata 1395061 cggagaccaa aagaaaatca cattcaaagg ccaggaaatt ataaaagcac tcggcttgtg 1395121 ggaagagaac gcagaagtga ccgttccgat tatagaaaat ccggcacata tcccgacgct 1395181 agcggcactg tttgcggaag agatttcaga agattcagga gctgttctga tccgaaatca 1395241 tggtattacg gcttggggga aaacagcatt tgaggcaaaa agagtgcttg aagcgtatga 1395301 atttttgttc agctaccatt tgaaattgaa aacactcgag catcagctgg ttaaataaaa 1395361 ggaggaattg aaatggctac aattcgaatt catgatgagg caaatacaac gattgaaaat 1395421 caagaggaag tggcaagctt tctggacagt caagaggtta tttatgagca atgggatatc 1395481 acgaggcttc cggaacatct ctcagagaaa tatgacctga cagaagaaga aaaacagcaa 1395541 attcttgata ccttcgaaac tgaaattaaa gatatctcaa cccgccgcgg ctataaagca 1395601 caggatgtta tttcattgtc agacagcaat ccgaaacttg atgaactgct tgaaaacttt 1395661 aaaagagagc atcaccatac agacgatgag gttcgtttta ttgtaagcgg acacggtatt 1395721 tttgtcattc aaggccagga cggcacgttt tttgatgtcc gtttaaaccc tggagattta 1395781 atctccgtgc ctgagaatat ccgccattac ttcacgcttc aggaggaccg caaagttgtc 1395841 gcggtgagaa tttttgtcac aactgaaggc tgggttccta tttatgaaaa agacagcgtg 1395901 aatcaataag cgtgagatag ccccgttcat cgaacggggc tttttatatt tattgcaaac 1395961 gccacttttc atattgtgac agttcttttt taatcagtgt ccaaatcaaa cctaaaacag 1396021 ctgcatcgtc aatgaatcca agaccgagga ttacgtctgg aatgatatcg agcggcatga 1396081 cgatatacag gattgcggca gttaacagca aaagtgtttt aacctgtgaa cgagggtagt 1396141 cgccatttcg ccaatcgcga agcatctgaa aaaaagtagt gatgtgctgg atacattttt 1396201 ttcggttttt cctctttaaa atcgcttttc cgcctgccgc tccgagcatt attgctttct 1396261 ttttcttcat tgggcatacc tcctgcctgg cggcgtgttt aagatattct tcacctgggt 1396321 attgttcttc taatcctatc aatatatcta ttatacctga aaaattaact tatttaatga 1396381 aaatatgttt acaaataaag tataatctgt aataatgcac aataacccaa tcaaacttgt 1396441 ttcctatttc ttagcggcga ggggtgaagt gaatgggcgg ttcttctgaa caagaaagat 1396501 tgttggtgtc tattgatgaa aaaagaaagt taatgataga tgccgctaga aagcagggat 1396561 ttacagggca tgacacgatc aggcacagtc aggagctgga ttgtttaata aatgaatatc 1396621 atcagcttat gcaagaaaac gaacattccc aagggattca aggccttgta aagaaattag 1396681 gcttgtggcc ccgcagagat gttatgccag catatgatgc aaataaatag cggcctatca 1396741 gatgcatata taaagagaga gcttttcgga agcgctcttt ttttctggaa aaaattcata 1396801 tgaaagaggg aactaatgaa ggaactggcg attctcatta ccgaaatggt caatcaattt 1396861 catgatgctt ttatttcctt atgcggaata tttggcattc atttaactga caaagaaatg 1396921 catttttggg tgatcggcat ttttggcata ttctttttcg gcgtcactca cgctgtgttt 1396981 acatggcttt ctaaatggag tatgacagcc ttgtccttta tctataccgt tacagtcatc 1397041 attgtcatcg tatttgcgat tgagattcag caaaaggtga cggggagagg gaatatggag 1397101 tttttagatg ccacggaagg tataaagggt tttttagtat tttttatgtt ttttttgctt 1397161 ttgaaaatgc tgttgcgttt catcaaaatc cttttttctg gaagaccagc aagcaaatcg 1397221 aatggcaatg cccgatcacg aagataaaaa accctcctga catggtcagg ggggctatga 1397281 tgcggatacg gggagggtga tcgtcacctc tgtgcctctt cgcacttcac tttcaatatg 1397341 aatagagcct ccgtacatca gcacgatccg tttacaaaca acaaggccga gaccggttcc 1397401 tttttcttta gaagtaacaa agggaaggaa gatgtgatcc agcatttcct gagaaatccc 1397461 ttcaccgtta tccacaactt tgattatggc ttttttatct aaagctccta gggagatcgt 1397521 cagtttgcct ccttcaggca ttgactcgag gccatttttt gctacattta aaatcacttg 1397581 tttaatatga tcttttgtac attttacgag taagggctgc tcggttagat actgtaattc 1397641 gacttcaaca ttgtatagat tgccctcaga ataaatgatc ggcataattt ctccgataat 1397701 gtcctgaagt gagttcagct cccatttttc agctgtcggc ttgccgagaa cgagaaactc 1397761 actcactatt tgattgatgc gctttatctc ctgttcgata atggagaagt aaagctgatc 1397821 ttcctcacct ttatatttct tttgcaacag ctgaataaag ccgcttatcc cggtgagggg 1397881 gttacggatt tcatgggctg tgctggcagc aagcgtcccg atcagctcta atttttgcgc 1397941 ctcgttttct gagcgctcca gctgggtctg ccgcttcagc aaataataca gcacgagaat 1398001 aaaaaggata ttcagcagaa caataataca tgaaagcgga agcacaaggc ttttcgacag 1398061 ttcttctatt gtgaccgggt tcggatagac tttcatattc cagctgatat catccagata 1398121 tccgctgaca ggtttctgat cctctgcatg agaggcttgt ccgctcgcaa aaatcatttt 1398181 cccgtcttgg ttcacaactt caatataaac atcagggctt agtaagttaa tgagattttt 1398241 caaataatca atttgaatag ctgcgacaag ataatctgtc acattacgtt ttgagtccaa 1398301 aacaggcaca caaattgtga aaattggctg accagtaatt ctgctcgaat aactatctga 1398361 aatgactgtc tttttagttt cctttgcttt tataaaaaaa gatctgtcgg ccaggtttac 1398421 tttcgttttt aattcggttg tgcttgcggt gacgtctcct ttggcattga gaaaatagag 1398481 accggaaaat ctcggctctg aatcaaaggt cttttccaaa attgattgca ttttctttat 1398541 atcaaccggt ctgtcgatgg cgatggacaa ggaggtcatt ctcgccattg tttctccgat 1398601 taaataattg attttgttgc ggtgaaggtt tagcaggaca cttgcttctt gtttatgttc 1398661 tgcagctatt gtatcttttt ctttttcata tacgaaaaag ctgatgacga ttgccggaat 1398721 cacgaccagt atgatataaa gtttgactct cccgcaggcg ccttttagta ttttcaattt 1398781 gcatcgctcc aacatacacc tgattagagg tattatatca ttgtttcttc ttctttaata 1398841 agaaaaaata accaaaaaaa ttagaaaaag atgttggcaa gcttacattt taaaaaagaa 1398901 gagaaatatt ggaaagattt ttattgacat tttggtcttt gtttattaat gtttctctgt 1398961 aacggtttct aaaaggatga ttgagacatg acagaaaaat cactgaagtt atttatcgtg 1399021 ctgtcgcgcg cgtatcggtc tattaacgat catatgaata agcatattca taagcatggg 1399081 ctgaatccga ctgaatttgc tgtgctagag cttttgtacc ataaaggcga tcagccgctg 1399141 cagcagatag gagataaaat tctcttggct agcgggagca tcacatacgt tgtagataag 1399201 ctggagcaaa aagaacttct cattcggaaa gcgtctccta cagacagacg agtgacattt 1399261 gcgcaaatta ctgaaaaagg catcggtctt ttgaacgata ttttccctga tcacgctgct 1399321 gaaattgatg aaatgatcag cgtattaagc gaagaagagg tagagatgtg caccgaaatg 1399381 ttaaaaagag taggattaaa cgcaaaacag tttcataata agtaaaaaaa ggaagcctga 1399441 tatgtcacaa ggcttccttt tttgctattt ttcatttgtt tccgctgcgc ctctcggcaa 1399501 aatgagaact tcaacccgcc ggtttttgct tcggccttcc gcagttttat tggaagccac 1399561 cggtttatac tcgccataac ccttggcgct gaacactttt gcatcgagct tggggttttc 1399621 aatcaggagc cccataaagt ttaccgctct catgacgctt aaatgccagt ttgattggaa 1399681 ttcagaattt ttaattggca tattatcagt atgtccgctg ataatgatat ttcttggcgg 1399741 gttaatcaca agaagatttg aaatctcttt tgcaagcggc acatcttcct tacggatggt 1399801 cgcttttcca gaatcgaaga agatgctgtc tttaatcgta atcagaaggc cttcactagt 1399861 catcttcgtc tccagctgat gttccagctt tttatctttg atgaactttt ccacctggct 1399921 cttcacattt tcaagttctt cttgatcagc tgctttttct ttttctttct tgtttttctc 1399981 tttctcttct ttttcctttt tcacttcatc gatgccgtct gactcgtttt caggaggagt 1400041 gacactggag tagtccagta caccggttcc gcctgtaaaa acttcattaa atgattttga 1400101 gagcatttga aacttagctg cgtcaatcga gctgctcgcg tacagcacaa taaacaatgc 1400161 caggagaaga gtaaggatgt cggcgtaagg aacgagccat gattcatcaa cgtgctcgtc 1400221 ctcatgcttc ttcttctttt ttctcgccat tttgcgcctc tccttgttct gcaaatttca 1400281 agcggtcctt cgcaggaaga tacattaaaa gcttttgttc gatgactttc ggtgcttgtc 1400341 cttctaaaac ggataaaaca ccttcaatca tgacctcacg cagttttact tcctgttttg 1400401 attttcgttt taatttattt gcgaaaggat gccataacac ataccctgta aagataccga 1400461 gaagtgtggc aacaaaggca gcactgatgg cgtgtccaag ctcatctgtg ttatccatat 1400521 gagagagagc ggcaatcagc ccgattacag cgccgagtac tccaagtgtc ggagcgtacg 1400581 ttcctgcttg tgtaaaaata gcggctcctg cttggtgcct gtcctccatt gcttcgactt 1400641 cctctgtcat aatatctctt ataaattccg cgctttgccc gtcaacagcc atgctgagcc 1400701 cgtttttcaa gaaagcatca tctacatcct caatgcttgc ttctaaagca agcagacctt 1400761 cgcggcgtgc aagctgagcc cattcagaga acataggaat gagttcctct attgtgagct 1400821 gtttattttc cttaaataac actcgaaaca gcgtaggcac ttttttaatt tcttttgttg 1400881 ggaacgcaat aacgactgct gagattgtcc cggcgataat aattaaaatg gcagcggggt 1400941 ttgcaagggc gctgaaactg acgcctttca gaaccatccc gacgctcaat gccacaaaag 1401001 caagaataat accgattaac gaagttttat ccatagtttt caccaaatcc ttttttacta 1401061 gcttgtctat ggttaatatc ggttttggtg cccggaactt tagggacatt gtgaatttgt 1401121 tcatgaaata ttcaaggaag aggcatagaa gggagaaata aacaaaaacg ggctctccaa 1401181 aattgaaaag cccgggggtc tactgaaatt agcagcttgc ttgcaagctg tccttcagat 1401241 ggtattcata taatagtaga aatacatatt cactgtatat aaacatgttc catccctcct 1401301 taaaaaagtg taaaggatga agggaagtag cgcttcagga gaagggacgg taatttctaa 1401361 gtcaagagta tgaaagtata aaaaaaagcg gcttcctaaa aggaaaccgc tgattgttat 1401421 tttgctcgca ctttgatttt atcatcttct aaaatcacgt gaaaacttgt gatctcgcca 1401481 ttatcaagca gcagatcggt catttcatcc tcaacccatt cttggatggt tcttctaagc 1401541 ggacgtgcac cgaatgaagg gtggtagccc agctcagcga ttttttcttt cgcttcatct 1401601 gtcacattca agctaatgcc ccgttccgcc aatgtttctt caagttctcc aagaagaagg 1401661 ctgacgattt tgacaagatg ttctttttcc aatgagcgga actcaataat gctgtcaaaa 1401721 cggttgagga actcaggttt aaagaacatg ctcagtgaat caattaatgt ttgttcttcg 1401781 atgacactgt catctgattg gaaaccgact ttcgtttgtt tctcaccagc acccgcatta 1401841 cttgtcatga tgatcacagt gtctttgaag cttacagttc tgccttggct gtctgtcaga 1401901 cggccatctt ccataatttg caggaacata tgctgaacgt ctgggtgtgc tttttcaatc 1401961 tcatccagca acacaatgct gtaaggattg cggcgcacct tctcagttaa ttgtccagct 1402021 tcctcatggc cgacatatcc aggcggtgaa ccgataattt tagatacggc gtgtttctcc 1402081 atgtattcgc tcatatcgag tcggataata gcgtcttttg tgccgaataa ttcatctgcc 1402141 agtgttttag aaagctctgt tttccctacg ccggtaggac cgacgaagag gaaggagccg 1402201 actggtctgt ttttggattt taatccggcg cggcttcgtc ttaccgcttt tgccactttt 1402261 tgaacagcgg cttcttgtcc gatcacgcgt tcatgaagtt ttgcttcgag ttctttcatt 1402321 ttcgtttgtt cgtctgcctg cagtttgccg acagggatgc ctgttttttg ttcaacaatt 1402381 tcctgaatgt gctcagcttc cacagtgaca gcggtatgag cggaggagct gttcagtttt 1402441 ttctccaatg cgagttcttc atcacggagt tttgccgcca gttcgtaatt ttcttcttcc 1402501 agggcttttg ttttttcggc ttcaattgca gttaagcgtt cagcggcatc ctcatcattc 1402561 agttcatcaa ttaacaggtt ggcttttgaa cctgcttcat ctaataaatc aattgcttta 1402621 tccggcaggt gtctgtcctg aatgtagcgg gatgataaag tgacacatgc tttgattgct 1402681 tcatcactga atgttacgcc atggtacgcc tcgtatttgt ctttaatccc ttgcagaatg 1402741 aggatagcct gttcaattga aggctcctgc accatgacag gctgaaaacg tctttccagc 1402801 gcggcatctt tttcgatttg acgatattct ttcagtgttg tcgcgccaat gacttgcagt 1402861 tcgcctctgg ctagggccgg tttgagaatg ttgccggcgt ccattgatcc ttctgcagag 1402921 cctgcgccga cgagaaggtg aatttcatca atgaacagaa tgacattttt tcgttccttc 1402981 agctcagtga tcagctgttt cattctctcc tcaaattggc ctctgatccc tgtgtttgca 1403041 acaagagatg caacatcaag caagtatagc tctttgtttt ttagtttgtt tggaacatca 1403101 ccttcagcaa tttttaaagc gagcccttca gcgatggcag ttttccctac acccggctca 1403161 ccaataagaa ccggattgtt tttgtttcgg cggtttagaa tttcgatcac tcgcgccact 1403221 tcatcatcac ggccgatgac gggatcaatg agaccggctt ttgcaccgtt tgtaatattt 1403281 tgagccagct catcaagcaa cccttttttt tcgctttgtt ttgctgcgct ctgttctttc 1403341 ggctggaatg cctgttcaaa cggaaatccg aaagattgag gacccatact cattgaaggt 1403401 ttacgggtca gttcgttata gcaagtttca caaagaacca tctgtttatg aacggaattt 1403461 atttgcatgt taaggcgaat cgtcgcctcg ttttgatgac aatgttgaca acgcatttgc 1403521 caaaacctcc ttaataattt gatcatcttt gaccaatgaa agtgaataaa aaggtctatt 1403581 gggtttgacc ttctttgact attagtatac ggcaaactta acggcattca aaccaatatg 1403641 ctcaaagcag actgaatatt tgactatctt tgaccaattg atttttaaaa aaggccggtt 1403701 tgtttgacca actttgatta atagtatact ctgactatct ttgactttca agtcttatgc 1403761 acaaaaattt ttgatttgtt acaaagtaaa acatgttttc ttcgtctttt caaggaactt 1403821 gtctcatagg ttataaaaag gcatatatgg acaaaactgc ggttcgttcg gagggaagaa 1403881 atggaacaat caaaagggtc tgcaagtcag cttgcttttg tgtatgtcgg cacagtagtc 1403941 ggagctggat ttgcgactgg gagggaaatt gttgagtttt ttctgaagtt cggctggttc 1404001 ggttttttcg gcattctcgt cagcggcgga atgtttacgt tactgggggc caagctgatg 1404061 atcatttcaa agcgaatcaa tgccaagtca tatcaagaaa tgaacatatt tttgttcggg 1404121 gcgacggctg ggcggattat caatgtattt atgctgtttg ttctccttgg agttacatct 1404181 gttatgcttt caggggcagg ggcgcttttt gaggaacagc tggggatgtc cgctcagatt 1404241 gggatgctca ttacaatcgg tctgagttta attgtgatga ctagaggagt aaaaggcatt 1404301 ttcggtgtca atgtgtttgt tgttcctctt ttaatcatct tttcaatgat tgtggtggcc 1404361 gactctttta tattcagcga atcacgaaac gcagctcagt gggtctggcc gcatcgctgg 1404421 gattggctgt tatcagcagt ttcttacggg gctttaaatt tatcgcttgc ccaagctgtt 1404481 ttggttccgc tggcgaatga aatgtcatcg gagaaagtga taaaaaaagg cgctttaatc 1404541 ggaggcacga tgctgacgat tgtgctgtcc gcgagttttc tgtctttgtc gactcttccg 1404601 gatgtatttt tgtatgatat accgatggcg caagtggttt atctctttgc acgatctgtc 1404661 catttgattt atttactcat tattttcgga gaagtgttca catcagttat cggtaatcta 1404721 tatggattag aaaaacaagt gcaaagcttt cttccagtga aaagcaaata tatctttgca 1404781 gccattatga tcacggctta tattacgagc caaatagggt acggcaggct tatttcaacg 1404841 atttatccct tgtttggcta tgtgagcctg gccttcatag gcgctttgct ttgcaaaaaa 1404901 gctcctcggc ggcgcagttt ataaatatat ataatgaaac gaaccgtcac tatagagcga 1404961 taattgatct aggaaccggg gactgacttt tttattgtca agaaaaacat cattatggta 1405021 agatagcaga agtgaaaaaa ttgaagaaaa tccgtgcgat atgcgggaga ggttctagct 1405081 acaccctcta taaaaaacta aggacgagct gtatccttgg atacggcctt ttttatgttt 1405141 ttctagagca ccttccgaaa aaaggtgttt ttttgcgtga attagctgta gcgatgtctc 1405201 tcgccggcgt ttttattgcg gagaaggaga ggaatcatga aaaaagaaaa agcaattgtc 1405261 gtatttagcg gcggtcaaga cagcacaaca tgcttactgt gggccttaaa agaattcgaa 1405321 gaagtcgaaa cggtgacttt tcattataat cagcgacatt cgcaggaagt tgaagtggca 1405381 aaatccattg cggaaaagct tggtgtgaaa aatcatttgc ttgatatgtc acttttaaat 1405441 cagcttgcac cgaatgccct gactagaaat gatattgaga tagaagtaaa agacggcgaa 1405501 ctgccatcca cattcgttcc aggccgcaat ttggtattct tatcctttgc gtctatcctg 1405561 gcttaccaaa ttggcgcgcg ccacattatt acaggagttt gcgagacaga cttcagtggt 1405621 tatcctgact gccgtgacga attcgtgaaa tcttgcaatg tcacggtaaa tctggcaatg 1405681 gagaagccgt ttgtgatcca cacgcctctc atgtggctca ataaggcgga aacgtggaag 1405741 cttgcagatg agcttggcgc gctggatttt gtgaaaaaca acacgctgac atgctataac 1405801 ggcatcatcg cagacggctg cggcgaatgt ccggcatgtc accttcgttc aaaaggttat 1405861 gaagaatata tggtgatgaa aggagagcgt gcataaattg ttatctcaaa tttatccgca 1405921 ggcccagcat ccttattcgt ttgaactgaa taaggacatg catatctcag ccgctcattt 1405981 tatccctcgg gaaagtgcgg gagcgtgcag cagggttcac gggcatacgt ataccgtaaa 1406041 tataaccgtt gccggcgacg aacttgacga ttcaggcttt cttgtcaatt tcagcgtact 1406101 caaaaaactg gtgcacggaa actatgatca cacgctatta aatgatcatg aagatttttc 1406161 tcaggacgac cggtattcgc tgccgacaac tgaagtcgtg gcgaaaacga tttatgacaa 1406221 cgtacaggct tatttagaca ctttggagaa taagccgacc tgtgtacagg tgtttgtccg 1406281 tgaaacaccg acaagctact gtgtctaccg tccgaaaaag ggtggtttga atggctaaag 1406341 gaattcctgt attagaaatt ttcggcccga cgattcaagg agaaggcatg gtgatcggac 1406401 agaaaacgat gttcgtccgg acagccggct gcgattattc ctgcagctgg tgtgactccg 1406461 ctttcacttg ggacgggtct gctaaaaaag atattcgctg gatgacggcg gaggagattt 1406521 ttgcggagct taaggacatt gggggagatg cgttttctca tgtgacgatc tcaggcggca 1406581 acccggctct gttaaaacag ctggatgctt ttattgaact gctgaaggaa aataacatcc 1406641 gtgcagcgct tgaaactcaa gggaccgttt atcaggattg gtttacgctg attgatgacc 1406701 tgacaatttc tccaaaaccg ccaagctcaa aaatggtaac gaactttcaa aagcttgacc 1406761 acattttaac ttcacttcaa gagaatgata gacagcatgc tgtcagcttg aaggttgtca 1406821 tctttaatga tgaagatctg gaatttgcca aaactgtgca caagcggtat ccgggaatcc 1406881 cgttttattt acaagtcgga aatgatgacg tgcatacgac agatgatcag tcactgattg 1406941 cacatttgct tggaaaatat gaagcgcttg ttgataaggt agctgtcgat gcggagctga 1407001 atctcgtcag agtgctcccg cagctgcaca ccctgttatg gggcaacaaa cgcggagtat 1407061 aatagaaagg aagatgaaca tgacgacaag aaaagaatca gaattagaag gtgtaacatt 1407121 gctaggcaat caaggtacaa attatttgtt cgaatatgca ccggacgtgc tggaatcctt 1407181 ccctaataaa catgtaaacc gtgattactt tgtaaaattc aattgcccgg aattcacatc 1407241 tttatgtcct aaaacaggcc agcctgactt tgcgacaatc tacatcagct acattcctga 1407301 tgaaaaaatg gttgaaagca aatcattaaa gctgtatcta ttcagcttca gaaaccatgg 1407361 tgacttccac gaggactgca tgaatatcat catgaacgac ttgattgaat taatggaccc 1407421 gcgctacatt gaagtatggg gcaaattcac gccaagaggc ggaatttcca ttgatccgta 1407481 cacaaactac ggaaagcctg gcacgaagta tgagaaaatg gccgaatacc gtatgatgaa 1407541 ccatgatttg tatccggaga caattgataa tcgttaatta ttccgttgtg tgatacggag 1407601 tgtaaaagga agtggagtca cagtaaaatc cgaacattca gcgttaattt tcagcggaaa 1407661 tgtgacctgg tcacagcgaa gtgtgacccg cactaagctc aataaaagtg ggaaaagtca 1407721 cacctgaaaa tggctctact catgggaatt gtattaaaaa gtgtgacctg aggtgcaacc 1407781 tgaactgtga cttttatgca gtgaaaaatt gatagtacag aagcagatta aggcgtacaa 1407841 tttgtacgtc ttttcttttt tatccgaaag aaaaaatgcc tatctagaga tcataggcat 1407901 taaatattat tatcaatatc ttcatttatt ttttggctaa gtttctgaac cttctcttta 1407961 acatttgaaa cagctctttt ttgaatttca tcaattctcc tgaatatagt cgatgacact 1408021 tcttattaga acttcacttt caaaattgaa tatctcattt atttctgact gttcttcatc 1408081 tgttaggtga tggtattgaa gttgtttagc atttacttca gcagctacat caatcctaac 1408141 ttagttgttc tggttgtaca atttcatatt caccttctgc atactcttgc tccgcataat 1408201 agcctcccca ttgacagagc tcctgcaaga taggtttaag agattctcca agttcagtgg 1408261 atgaatattc aaccttcggc ggtacttgat tatacatctt tctgctcaca agtccactgg 1408321 cttcaagctc tctaagtgtt tgaatcagca ttttctgagt tatatttggg ataatgcgct 1408381 ttaattcact cgttctcttt ggtccattca ttaaaaagta taatacaagg cctttccatt 1408441 ttccgccaat aacttccttt gtcacttcaa acccacagct aaattttttc atgtctaaag 1408501 ctctccattc cacatttatt actttttagt tactatatca caaaaaagtg ggtacttccg 1408561 ataatgtgct tactgaagga tactatatct tgtaagttgt tcttcaagta cttaaaggta 1408621 ctagacataa aataaaatta attctaaagg agtgttaagt atgggtaaat ttgaaggtaa 1408681 aatagcgctt gtaacgggtg gaacaagtgg gattggtctt gctacagcac aaaaatttgt 1408741 aaacgaaggt gcatatgttt atattacggg acgtagacaa aacgaacttg ataaagctgt 1408801 taaccaaatt ggcaagaacg taaccggtgt tcaaggtgat atttctaagc ttgaagactt 1408861 agacaaacta tatgacatta taaagcagga aaaaggtaag ttggacattc tttttgctaa 1408921 tgcaggcatc ggcaacttcc ttccattagg tgaaattact gaagagcagg ttgatagaac 1408981 gttcgacatt aacgttaaag gaaccatctt tactgttcaa aaagcgttat cactattccc 1409041 ggacaaagta ggttctatta ttgtaacggg ctctactgct ggatcaattg gcaacccagc 1409101 gtttagtgta tatggagcat ctaaagcagc attaagagca ctagttcgca actggattct 1409161 tgacctaaaa ggtactgaaa tccgtgtaaa tgtggttagt ccaggaggta ttcttacacc 1409221 tgcctacgat gagctttttg gtgatgcact tgaagaggta ctggaaaata gcagaaatac 1409281 tgttccagct ggaaaagttg ggacacctga agaagtagca aacgctgtat ctttccttgc 1409341 ttcagacgaa agcagttact tgacgggtgt tgaattgttc gtagatggcg ggctagcaca 1409401 ggtataattt cactgcgcag agattacaaa tagtccccaa aaaaggttaa tggggattta 1409461 cttgaagaag tcgtataaaa aagtcgtttt ccttaaagga cagggaattc gactttttta 1409521 tatttgaatt tgattaacgt tgtaaattcg cattttcctg gggctactac taaatgacct 1409581 gtaaaaaaga ttacactgtg aataaatgta cttaaagtaa cgggggctct tgacttttaa 1409641 taaaaaataa tatccctgtc cttgtattct aatactttta aaaatattta aaggaatcct 1409701 tatgtcctga ataaccacat aggaaaatat gttgtaggtt gctttctttt tttgtggggc 1409761 atcccacaca agctatctcg tgatctcaca cctgaacgtt ttttatagac tagtaccgcg 1409821 acaagttata ttacatatac ataccaataa agtagacatt aaaaagtgaa agagaggatg 1409881 gaaatgtgtg aaaattcttt tccttgagag tcatcccatg tggctctatg gtttaccgaa 1409941 tgggtttagg gaagcaggac ataccgtaat gatttccggt cctgtaagtc gggaaaatat 1410001 aactgaaatg atagacgaat ttaaaccaga tttaatagta tctatgggat ggacaccaga 1410061 gcattcaagg gaaaagcagg cctggattcg caacgctact aaaaaggtga atatccctct 1410121 cgtttattgg gcaactgaag acccgctgca cactcaaaac tttactatcc cgttaattaa 1410181 aaagatgaaa ccggattttg ttttcacggt cacgccttct ctgtgtaaaa cttatgaaag 1410241 catggggatt aaagcagctc acttagactt tgcatttcac gaaagtatac atcaccagat 1410301 taaaccatta gcgaaataca gttgtgatat agcagtggtg gctaatgctt accctaattt 1410361 tcttgaagaa catccggaag tgttccgttc gtcctcttta aaaacgctta ttcgtcctct 1410421 tatacggaag ggtattcgca ttgatttttg ggggagaaac tgggaaaaaa tgagtaaata 1410481 tataggaaga gaaattcccc gcaattggat ccatggatac cttgattata ctgaagcata 1410541 taaagtttac agttcagcaa aaatcattat cggtttgcaa aactgtgaaa gccaacttac 1410601 acaacgcacc tatgagattc ttggttccgg ggggttttta ttgacatcgg atacaccagc 1410661 agttcgaggt aaattcaaac ctggccgcga tctcatcgtt tcttcctccc caaaagaaac 1410721 attggaaaag gttaaatact atttaaatca tgatagcgag agaaaaaaga ttcagataaa 1410781 cggtaaaaag gctgtaaaga atgattccta tcggcataga gccgagagaa tgcttgaggt 1410841 gctaaaaagc agaggaatca taagaaactt aggggaaacc attcattatg tagatgttct 1410901 caaagaaaaa tacgtgatcc atcatgttac tcccggtgaa acattatcaa taattgccag 1410961 taagtataat gtttccctgc agcaactcat ggagcttaat catttcaaat cagatcaaat 1411021 atatgctgga caaatcatta agattagaga gaaactgttt agaaatatta ataacaaatt 1411081 attctaaagg agagtaatat gaatgaaggg gaaaatacct aaaataagaa atcaagcgaa 1411141 taaagtaaaa agaacgcctc gttatatgga atttcccgtg acatacgaag tatatcatgt 1411201 ggaatccggc gatacattat ggacgattgc caaatccttt gaaattccgg tacaacaact 1411261 tatgaatctt aataagcttt cttcagatag aatttatcct ggacaaatta taaagataag 1411321 agaaagataa tctttgaggt ttcggaagcg aatcaaattg aaatgacaat cctcattttt 1411381 ttatttgtgg ggaacttgat atttttgggg atgaaggggt tatgagatgt ttcaaatgag 1411441 ctattactat tctggattag gatgggactt tattcaacac gttgatcaaa cgaacggagt 1411501 attaaatgtt gtgtctcctg attttttcta tatcagaaaa gatggatcat tacttctccg 1411561 ttcagctaat cccgatgtga ttaaagctct tcatagaaga aaattaaaag tagttccttt 1411621 tctaagcaat cattgggatc aggatttggg acgatttgca ttaatgaacc gagttctttt 1411681 agctaaacaa atttctcatg caatagaaga actggatttg gatggagtta atatcgatat 1411741 agaaaacctt acagaaaaag atcggaatct atttacagat tttattagat tagtaaggaa 1411801 aagtattcct agacataaag aagtatcagt tgcagtggcg gcaaatcctt ttggctggac 1411861 gaagggctgg cacggatcat atgattacga gtatttagct aaatatgcag attatcttat 1411921 ggttatggcc tatgatgaaa gccgccttgc tgggcctact gcaagtgtag gatgggtgga 1411981 aaagtccatt caatatgttc tgacccaaaa aatctctcct caaaaactag ttttaggatt 1412041 gccattctat ggccgctgct ggatggaagg ccaatctgcc tctcaagcca ttccccttta 1412101 ccttgttgtt agtaaaaagg catagcggga caattatttt tgacaccaag agtcaatctc 1412161 caaaagctat ttttactgtc aatcacgata aaaaggggcc gttgccttcg ggaacatata 1412221 cattatggtt tgaaaatgaa cagtcactca gagcaaaaat aaaactcgct caaaaatata 1412281 atctgaaagg tcttggcagc tggagtcttg gacaagaaga tgcgtcagtc tggaatacag 1412341 tgtttaaaaa tatataatga tttatagttc agaacaaaat tcgaagataa ttgcaatgaa 1412401 tctctaaatg gacatactga aaggagttta ttacgagtgc gggtaaaaca gtgagggcat 1412461 tccataggcc cttctcccaa aatgttctac acgaggcatt acattgggct tgaaatacac 1412521 attcaaactt atgttatagt acgcatttta cggatgtgtt gaatttattc tgcttccatg 1412581 atttaatcat acacatgcta cttgatagca gggttatcgc atttcattca gaattgttca 1412641 ggatcgatat ggaagcgcac gactaactag aactttaaaa gcatacactc atatacttcc 1412701 tgaatggatg ctggtttatc taaaaaacat gatgagaatt gattgtacgc atggtgaagc 1412761 atgacttgtt gataatcgac catatggttt ctccttagaa atgagggggt ttttacataa 1412821 aaaagacgag cgaatccggg gggaattcca ctcgccgctt tctaatgaaa agacgggatg 1412881 ctggatggca gctcgtctgt tttattataa tttaacgaac gtatgtttgt aaaggtgtct 1412941 tttcgaatga attggttcat ataaccgtta agaacagatt cattgtaaac attcgctaag 1413001 gtatgctaag atgcatggac tataaaggag tgatatgaag tgaagacatt gcggttaaac 1413061 aatgtaacgt tagaaatggc tgcatatcaa gaggagagcg agccgaagcg aaaaattgca 1413121 tttaccttaa acgttacgag tgagacttac catgatatcg ctgtcctgtt gtatgaaaaa 1413181 acgtttaatg tcgaggttcc ggaacgcgat cttgccttcc ggggggaaat gacaaattat 1413241 tcaacatcat tgaccaacct gtacgaacca ggggccgtca gcgagttcta tatagaaata 1413301 acggaaatag acaaaaacgc cgattcatga tcggtgtttt ttatgtaaaa aagctgccgg 1413361 ccggcagctt ttgagaaagc gaatttcata tgtaaggtgt taaattgtcc gtcttgcagt 1413421 tttttgaata aatgtggaaa taaggaggtt ttaataggag tctctgatga tcttataatt 1413481 tttatgatta acaactgtca atgaatctaa ctcaagatcc cgatagttat ccatgatcgt 1413541 cacatcaacg ataacagaat tctcatttac tttttcaaca acaccggtta atccgttttt 1413601 aaattcaatg acattcccaa ccttagcgat tttcacaagc ttcctctcct ttaaacataa 1413661 taatgccttt tgaaagtatt ttgcagtatt ttcattgaga agtaaagcga taaggagttt 1413721 tatctccctt atgaattgtt ctgtcgctat aaagatgata tattgatttt cgtcaataga 1413781 aagaaaaggg gggaattttt gttgcgtccc gaagaaataa cagaaatgat tgaacagctg 1413841 cgcaccggcg ccataaacga actgagagtc cagaaagagc attttcttga tttcagggcc 1413901 gtgttatcta aacaagatga ttttaaacat ttccgaggaa ttgcccagca aggcggagat 1413961 gttatctttc aatacttaga acagccaaga agctgaaggt ttctcatacg tgagaagcct 1414021 ttttatcata tatgacagaa cacaagcctt ttattacagc tgtctgtaac aggtgtaaat 1414081 aaaatgtaaa gtaccaaaga tggataaaca tgttttaatt taacaatatt tatagaattt 1414141 cagactgttt ttttgccatt aagcagtgag tcatcctctt tattccatcc tgatacctcc 1414201 ttgggagagt tggaaaatct ttttccgtga aaatgaatgg atctcttgtt aaggttatga 1414261 agtgtttttt ggagcacttt aaggaggaaa ctgtatgaca acgaaattca ctgctctggc 1414321 tgtttttctt ctttgtttca tgcctgcagc caaaattgag catacacaag cttcactact 1414381 gagcgcaaag aagacaaaac atgaagaagc gaaatggctt acacatatag atcgaaatac 1414441 gaatgaatct ttcccttcac tgtctgctga taaagacaag aaaataaaac cgattaagct 1414501 atcagcacac actgaaaaga aagagaaaga taaaccggac aaaacaaatg atgagaaaga 1414561 aacatataca cagtctgaaa aagagttgct gtcccgtctc gttcacgcag aggccaaagg 1414621 agaatcatat aaaggcaagg tcgctgtagc aagcgttgta ctgaacagga cggagaaaaa 1414681 aggttttcct gatacgataa gaggagttat ttatcagaaa aacgcctttg aaccggtcgc 1414741 aaacgggagc attaaccaaa agcctgataa agaatcgatt gaagctgccg aagaagcgct 1414801 gtcctcaaaa aatagagaaa cagatgccat attcttttat aatccgaaaa cagcgtcaga 1414861 taattggatt cgttcaagaa aaatcgtaga aaaaatcggc agacacgttt ttgccgtcta 1414921 agcatagaag agacaatttg tctcagctgt gctttttttc atataaagag taaaaataaa 1414981 ataatttttg aacttgtctc atatgatgtt ggtagtacaa gagacaagga gagacatcat 1415041 gaatcgattt gtgaaaggga tcattctttt atccattgcc gcctttttcg ctgaatgcct 1415101 tgaatttgtc gtcaatatga ttttggcgcg ggagcttggc gagcatggga tggggcttta 1415161 catgagtatt ttgcccacga tctttttaat tattgtcatc gcgagcctgg aactgccgat 1415221 atccatttct aaattcattg ccgagtcaaa tcctaagctt catgaaagca tgctgaggca 1415281 cgctttcaga atgacagcca tttttactgc tttttctact gccgccgcta gtattgcgct 1415341 tccgtttatt ccggtatttg atacatacca cccgtttatt aaagggattg tcatcggctt 1415401 aattcctgtt gtcgccttta cttcaatcgc caggggctac tttatgggtg tgcagaaaat 1415461 ggggaagatc gcaattgcca atgtgctgaa aaaaatcatc cagctcttgt gcttattcct 1415521 cttttttcaa tggtactcat ttgaattgga catggctgtg ctgatttcct tgtttgttct 1415581 agtcgtgagt gatgtggtcg tgcttgttta tttatattca caatttatca tggcaaggcg 1415641 ggcgttatcc ggccagcagc acattcattt gcgcggaaag gatgtaagga aaagactgct 1415701 tgctgtttca attcctacaa caggactgcg tatttttcat gcggttgtca atgcaattga 1415761 acccttttta gtaaaaggag ctcttttggc tgcgggcgtt gccgggacag cggcgatcga 1415821 tcaatacgga atgctggcag gagtggctgt gacgataggg tcgttccctg cttttattgc 1415881 ccattcgtta atggtcgtca tgataccgag tatttcggaa gcttatgcac tttctcagta 1415941 tgacatcgtg ttaaaaaggc tgaagcagtc gattttcatt acattaggtt acggtatacc 1416001 tgccgtctgg gtcatgttcc agtttgcggg acctctcacg catttgtttt ttcactctcc 1416061 tgaagcgcag tattacttgc agctgttgtg gccttacttt ctctttcatc tgtttgtcat 1416121 gccgctgcag gcgtgcttaa tcgggatggg ttttgtgaaa gaggcttttt atcacaatgt 1416181 atggagccat atcgttgcgc taagtatgat gtatgtactg ggatcaatgg agaatctgca 1416241 aatgctcggg attatccttg gaatgaacac tggcatgatt cttttgacga gcctgcacta 1416301 tgccacgatc tgcaaagcat tgaaggtatc tgtatttctt acgggaggga ccagaacgcc 1416361 gcgaattgaa ggatgataaa ggaacagcag gggcaagcta attgaaaagc atgaaaggaa 1416421 gattccatgt tgacgaagcg cttgcttact atatacatta tgttattagg gttgattgca 1416481 tggtttccag gtgcggcaca agctgaggaa aaacagcctg ctgttcccgc tgtttttctt 1416541 atgaaaacga tagaagggga ggacatctcg attccgaata aagggcaaaa aacaattctc 1416601 catttttgga cgtcatggtg cccgccctgc aaaaaggagc ttccacagtt tcaatcgttt 1416661 tatgatgccc atccatccga cagtgtaaag ctggtaacgg tgaatttagt gaattcggaa 1416721 caaaatcagc aagtcgttga agactttatt aaagcaaaca agctgacgtt tccgattgtc 1416781 cttgactcaa aaggggaatt gatgaaggag tatcatatca tcacgatccc aacatcattt 1416841 ttgctgaatg aaaagggaga aattgaaaaa acaaaaattg gcccgatgac agcggaacaa 1416901 ctgaaggaat ggacggaaga atagctgaga gcatagactc tcagcttttt tcatatagag 1416961 aagaagtgaa taaacattaa tgataattat tatcaaaaag aaattaaaat aattataatt 1417021 gaaattctct tcgtgcgtgc tataataaag gaagacatca agaaataact gacgataaag 1417081 ctgccttttg ggcagcgatt ttgtttttat aagagaaatg aagatgattt acgttctcaa 1417141 ttagagagga gaattcgata tgaatgaaca agttatcgtt caacgcgacc cgcatgagcc 1417201 attgaaaaca gacaagaggg aaaaaaactg ggcacagcac gcggagctta ttgcagcact 1417261 tgtatcaggc gctcttattt tggcaggctg gctcttatcc ggatatcagg tattatccat 1417321 aatacttttc ttgctggctt ttgtgatcgg cggatttgct aaagcgaagg aaggaatcga 1417381 agaaacactc gaatccaaaa cgctgaatgt agaactttta atgattttcg ctgccattgg 1417441 ttccgccttg atcggatact gggcagaggg tgctatttta atatttattt tttccttaag 1417501 cggagcttta gaaacataca cgatgaataa aagcagcaga gatttaacgt ctttaatgca 1417561 gcttgagcct gaagaagcga cattgatggt caatggtgaa accaaaagag ttccggtttc 1417621 agacttgcag gccggtgata tgattgtgat caaacctgga gaacgcgtag cggcagacgg 1417681 tatcattgaa tcgggctcga caagtcttga cgagtcggct ttaacaggtg aatcaatgcc 1417741 tgtagaaaaa aacacaggcg acactgtatt cacaggaacg gtgaatcgca atggctcctt 1417801 gacagtccgt gtcacgaaag caaatgaaga ttcgttattc agaaaaatta tcaaactggt 1417861 tgaatcagcg caaaatagtg tttcacccgc gcaggctttc atcgaacgat ttgaaaatgc 1417921 ttatgtgaaa ggtgtgctaa ttgcggtggc gctcctttta ttcgtcccgc actttgcgct 1417981 gggctggagc tggagtgaaa ccttctaccg cgcaatggtg tttatggttg tcgcgtcacc 1418041 ttgtgcgctt gtcgcctcta ttatgccggc ggcgctgtcc ctgatttcaa atggcgcccg 1418101 caacggtatg cttgtgaaag gaagcgtctt tcttgaacag ctgggctcag tgcaaatgat 1418161 cgcctttgat aaaaccggaa ctgtaacaaa aggccagcct gccgtagaga cgatcagaat 1418221 agcagaagga ttcagtgaag cggaagttct tgaggctgtc tatgccatcg aaacgcaatc 1418281 aagccatccg ctcgcccaag ccataacggc gtacgctgaa agccgcggcg tgaatcagtc 1418341 cggctacata tctatagaag aaacctcagg gtttggcgtt atggcagaag tgtcgggtgc 1418401 gaaatggaag gtcggtaaag caggttttat cggcgaggaa atggcagcac aatttatgaa 1418461 acaaacagca tcagatgtca ttcaaagcgg tcatacaatt gtatttgtga aaaaggatga 1418521 tcaaatagca ggctgtatcg cactgaagga ccaaatcagg cctgaagcaa aagaggtcat 1418581 ggaagaactg aaccgacttg ggattaaaac ggccatgctg acaggagatc acgaagacac 1418641 ggctcaagcg attgccaagg aagccggcat gacaactgtc gtggcagaat gcctgcctga 1418701 ccaaaaagtg aatgaaatca aacggttaaa agaagaattc ggaacgattg caatggtggg 1418761 tgacggaatc aatgatgcgc cggcactcaa agcagcggat gtcggcattg cgatgggcgg 1418821 cggaacagat gtagcacttg agaccgctga tatggtcctc atgaaaaacg atttgaaaaa 1418881 gctcgtaaac atgtgccgct tgtctcggaa aatgaacagg atcatcaaac aaaatatcgt 1418941 gttttctcta gctgtaatct gcctgctgat ttgtgcaaac tttttgcagg cgatggaatt 1419001 gccatttggc gtgattggtc atgagggcag cacgatttta gtcatactaa acggtttaag 1419061 actcctaaaa taaaaccagc agcctaatca ggctgctggc tttttatgta tcaagctttc 1419121 ccttcatttt tgtctttatc agatcttttc ataactagga tgagagcgag ggtgcagcaa 1419181 aggaaacccg ctgcacagcc tatgatagag ctgtaataat aaaagcccac catcttcatc 1419241 ccgataaaag gagcggaaat tcccaaaacc gttaagagca taactgcttt tcgtctgaaa 1419301 aaattcatca gcaaacggaa caacccccct gcgattgaac gttactgtca gtatacagga 1419361 agaggagcag gaaataaaat gcattagaaa atgaaggcgt cgtgaaaggc aaacaccggt 1419421 aaaacctgtt acaatggaag acagaacaat gcattgcaaa tggcagggag gaacaagaag 1419481 tgaatagaat acaacgcgtc tcttcatggc tgaaggaagc ggggcatact gccgcattta 1419541 ttcatacgaa agaaaatgtt ttttacttaa ccggttttta cacagagccg catgaaagat 1419601 taatggggtt atttattttt caagaagagg agcctttctt tgtttgtcca ggaatggaag 1419661 caggacaggc ccgcaacgca ggctggaatc atgaaatcat tggctatgcg gatcacgaaa 1419721 atccgtggga gctgatagag aaggctttga aaaagcgaaa tatcagcata catatgcttg 1419781 cggtagaaaa ggattcaatc tcgctgtcac gtgcagaaca gctgaagcat gcgacgggcg 1419841 gggctcaatt tgtttcagca gaagaaacac tcaatcaatt tcgcctgatt aaagatgaca 1419901 atgagattcg tttgctgaaa gaggcggcaa agcttgcaga ttacggtgtt gaagtcggca 1419961 cagccgcttt gcgtgaaggc atcagtgaag tggaagtgct cgctcaaatt gagtatgagc 1420021 tgaagaaaaa aggaattcag ggcatgtctt tctctacaat ggttttattc ggagaaaaat 1420081 ctggccagcc tcatggaaat cctggtacag ccacgttgaa gaaaggtgat tttgttttat 1420141 ttgatctcgg tgttattctt gatggctatt gctctgatat tacaagaacg tttgcataca 1420201 aaaccatcaa tccgaagcag gaggccattt acgagactgt gcttcaagcg gaaaaagccg 1420261 cgattgaggc aagcaaaccc ggtgtgagaa tcggagatct ggatttaact gcccgcggaa 1420321 tcattgaaaa agcgggatat ggtgattatt ttcctcaccg gcttgggcat ggactcggaa 1420381 tttcagtcca tgagtatcca tcaatgagcc aggccaacga tacactgctg caggaaggca 1420441 tggtctacac gatcgaaccg gggatttatg tgccagagat cggcggcgta cgcattgagg 1420501 atgacgttca cgtaacaaag gacggagcag ttgctctgac ccaatatcca aaggatttga 1420561 tcatactgta atagaaataa aaaaggactt tgttctcgac atcgtccttt tttatctgca 1420621 ttaaataaaa aaatcatcaa atgttcgaaa gggtttaatt tcatgttttt ggttgagagg 1420681 ttttacagca agacagctgc caccgagaac agtgagacat aacccaatta aaatgaagaa 1420741 acccatgtga tcttctcctt tcagctaaaa acacaaaaag atatctggta cgtccatatc 1420801 atattgtatg aaacgcattc cagatcaagg ggatttagaa agaagggaat ctatggctaa 1420861 tattaaagac attgcagaga aagccggtgt ctctgttaca acggtttccc gagtcataaa 1420921 caatcatcca tacgtcagtg aagacaaacg aaaaagagtg tttgaggcaa tggaatcatt 1420981 ggagtacacg agaaatattc acgctgtaca tttgtcgaaa ggattttcaa acatgattgg 1421041 tgttgtcttg ccgacggtta atctgccata ttttgcagag ctgattgcag gaatagccga 1421101 cgcagccgcg gaatccgggg ttcacctctc tttattccaa acaaactatg aagtacaaaa 1421161 agaaatcttt gcgctgtccc aattaaagca gcgccaggtt gacggcctga ttttttgctc 1421221 aaaggcgctt gctgatgaga aactcatgga atgggagggc ccgattttgc tttgccagaa 1421281 ttcagataat gcccgcttcc caaccatcag cattcctcac caagaagcat ttcggaacgg 1421341 cttggactat ttaattgcca aagggcacaa aaaaatagcc atctgtttgg caagaaaaaa 1421401 aggcatgaac agccattttc gaatcaaagc ctacaaagag gcattggaag agatcggcga 1421461 ggcatttcgt gaagactggg taattgagaa agcgattaca atcaatgatg ggaaggcgct 1421521 ttttcataaa tggaatacgt ggaaggaaaa gccgacggct atttttgttg ccaatgacca 1421581 agtctcagca gggctttttc ttgaagcaaa gaaccagcgg gtgtcagtac cggatgagct 1421641 tgcaatctta agcgttgata accacgaaat cagccaagcg cttggaatca caacgatcga 1421701 tattcagaca agggaaatgg gaaagcaggc atttgccata ttggaaaaaa gaattcaagg 1421761 acagccgatt gaaaggaaag ttctggatta ccgtctcatc gaaagatcga ctgtttagtg 1421821 aatgcattga aaaaaggttt gacgtgcatt ctgttcgtta tgtacgatat gaggtattga 1421881 atgacaaagg agctgaggat cgtgaatggg tccttcacag tgaaaaaggt actgaataat 1421941 aacgtattaa ttgcttctca tcataaatac agcgaagtcg ttttaatcgg aaaaggtatt 1422001 ggtttcggaa aaaaacaaga tgatgtcatt gaagataaag gctacgataa aatgttcatt 1422061 ttaaaagacg agaaggaaca aaagcagttt aaaaagctcc ttgactatgt tgatgaaaag 1422121 ctcgttgata tttcaaacga tgtcatctat cacataagca ataggacgaa tcactcatta 1422181 aatgaacata ttcacattgc gttgacagac catatcgcat ttgcgatcaa aaggcagcag 1422241 cagggatttg atatgaaaaa tccatttcta atggagactc agtcactata tcctgaggag 1422301 taccaaattg ccaaagaagt catagatatg atcaatgaaa aagcgggact ctgccttccg 1422361 gaaggggaga ttggttttat cgctctgcat atccattcag cgttgacaaa ccgtccgctg 1422421 tccgaggtca atcagcactc tcagctcatg gcgcagcttg tcgaggtgat tgaagactca 1422481 tttcaaatga aagtaaataa ggaaagtgtc aactatttgc ggctgatcag gcatatcaga 1422541 tttacaatag aaagaattaa aaaagaagaa ccgactaaag aaccagaaaa attaatgttg 1422601 ttattgaaaa atgaatatcc gctatgctac aatacagctt ggaaattgat taaaatcttg 1422661 cagcaaacat tgaagaaacc agttcatgag gcggaagcgg tttatctgac gcttcatctg 1422721 taccgattaa ccaataaaat ttcataaatt cagtttatcc ttataacgtg ttactgattc 1422781 gatcaggcat gagtgattga gggaaaaaaa cgggaagttc attctcgttc ttttgcgcac 1422841 ccaattttgc tcatgccttt ttgttgtgta aaagggcaaa tgtaaacggt taaactggaa 1422901 gacttacgcc tgtgaattcg ttgtcatgat ttttagctgt aaggtcagac tagtaaaaag 1422961 aggaggtcaa ttcttatgtt taaagcatta ttcggcgttc ttcaaaaaat tgggcgtgcg 1423021 cttatgcttc cagttgcgat ccttccggct gcgggtattt tgcttgcgat cgggaatgcg 1423081 atgcaaaata aggacatgat tcaggtcctg catttcttga gcaatgacaa tgttcagctt 1423141 gtagcaggtg tgatggaaag tgctgggcag attgttttcg ataaccttcc gcttcttttc 1423201 gcagtaggtg tagccatcgg gcttgccaat ggtgatggag ttgcagggat tgcagcaatt 1423261 atcggttatc ttgtaatgaa tgtatccatg agtgcggttc ttcttgcaaa cggaaccatt 1423321 ccttcggatt cagttgaaag agccaagttc tttacggaaa accatcctgc atatgtaaac 1423381 atgcttggta tacctacctt ggcgacaggg gtgttcggcg gtattatcgt cggtgtgtta 1423441 gctgcattat tgtttaacag attttacaca attgaactgc cgcaatacct tggtttcttt 1423501 gcgggtaaac gtttcgttcc aattgttacg tcaatttctg cactgattct gggtcttatt 1423561 atgttagtga tctggcctcc aatccagcat ggattgaatg ccttttcaac aggattagtg 1423621 gaagcgaatc caacccttgc tgcatttatc ttcggggtga ttgaacgttc gcttatccca 1423681 ttcggattgc accatatttt ctattcaccg ttctggtatg aattcttcag ctataagagt 1423741 gcagcaggag aaatcatccg cggggatcag cgtatcttta tggcgcagat taaagacggc 1423801 gtacagttaa cggcaggtac gttcatgaca ggtaaatatc catttatgat gttcggtctg 1423861 cctgctgcgg cgcttgccat ttatcatgaa gcaaaaccgc aaaacaaaaa actcgttgca 1423921 ggtattatgg gttcagcggc cttgacatct ttcttaacgg ggatcacaga gccattggaa 1423981 ttttctttct tattcgttgc tccagtcctg tttgcgattc actgtttgtt tgcgggactt 1424041 tcattcatgg tcatgcagct gttgaatgtt aagattggta tgacattctc cggcggttta 1424101 attgactact tcctattcgg tattttacca aaccggacgg catggtggct tgtcatccct 1424161 gtcggcttag ggttagcggt catttactac tttggattcc gatttgccat ccgcaaattt 1424221 aatctgaaaa cacctggacg cgaggatgct gcggaagaaa cagcagcacc tgggaaaaca 1424281 ggtgaagcag gagatcttcc ttatgagatt ctgcaggcaa tgggtgacca ggaaaacatc 1424341 aaacaccttg atgcttgtat cactcgtctg cgtgtgactg taaacgatca gaaaaaggtt 1424401 gataaagacc gtctgaaaca gcttggcgct tccggagtgc tggaagtcgg caacaacatt 1424461 caggctattt tcggaccgcg ttctgacggg ttaaaaacac aaatgcaaga cattattgcg 1424521 ggacgcaagc ctagacctga gccgaaaaca tctgctcaag aggaagtagg ccagcaggtt 1424581 gaggaagtga ttgcagaacc gctgcaaaat gaaatcggcg aggaagtttt cgtttctccg 1424641 attaccgggg aaattcaccc aattacggat gttcctgacc aagtcttctc agggaaaatg 1424701 atgggtgacg gttttgcgat tctcccttct gaaggaattg tcgtatcacc ggttcgcgga 1424761 aaaattctca atgtgttccc gacaaaacat gcgatcggcc tgcaatccga cggcggaaga 1424821 gaaattttaa tccactttgg tattgatacc gtcagcctga agggcgaagg atttacgtct 1424881 ttcgtatcag aaggagaccg cgttgagcct ggacaaaaac ttcttgaagt tgatctggat 1424941 gcagtcaaac cgaatgtacc atctctcatg acaccgattg tatttacaaa ccttgctgaa 1425001 ggagaaacag tcagcattaa agcaagcggt tcagtcaaca gagaacaaga agatattgtg 1425061 aagattgaaa aataagggtg ttagtacgcc gtgcttgtca gatgacaagt acggttgtat 1425121 gatataatat tgtgaagtaa taaagcttta agttaaaagg agaatgataa aaatggcaca 1425181 aaaaacattt aaagtaactg cagattctgg aatccatgct cgtcctgcga cagttcttgt 1425241 acaaactgct agcaaatacg acgctgacgt taatttagaa tataacggca aaacagttaa 1425301 ccttaaatct attatgggtg ttatgtcttt aggtatcgct aaaggcgctg agatcacaat 1425361 ctctgcttcc ggagctgacg aaaacgatgc tcttaacgct ttagaagaaa caatgaaaag 1425421 cgaaggactc ggcgagtaat gcaagaatta aaagggattg gtgcttcagc cggcatcgcg 1425481 attgcaaaag cgtaccggct tgaagagcca gatttaacgg ttgaaaagaa aaacatctct 1425541 gattctgaag cggaagtaag ccgttttgat gaagcgattg cacgttcaaa agaagagctc 1425601 gaaaaaatca aagagcacgc tttgaaagaa ctgggtcagg ataaagctga tattttttct 1425661 gctcaccttt tagttctcag tgaccctgag cttctgaacc ctgtgaaaga aaaaatcagc 1425721 actgattcag tgaacgctga attcgcttta aaagaaacgt cttctatgtt cgttactatg 1425781 tttgaatcta tggacaacga atatatgaaa gagcgtgcgg cagatatccg cgatgtaaca 1425841 aaacgcgtaa ccggccacct gcttggcgtc gaaattccaa acccaagcat gatctcagaa 1425901 gaggttatta ttgtagctga agacttaaca ccgtctgaca cagctcaatt aaaccgtgag 1425961 ttcgtaaaag gattcactac tgatatcggc ggacgcacat ctcactctgc catcatggca 1426021 cgttctcttg agattccagc agttgttgga acgaaagctg ctacaggcac gatccaaaac 1426081 ggcgtgactg ttatcgttga cggtatcaat ggcgatgtca ttattgaccc atctgcggaa 1426141 actgtaaaag agtatgaaga aaaacataat gcttatttgg ctcaaaaagc tgagtgggcg 1426201 aagcttgtca atgaaccgac tgtctcaaaa gacggacatc atgtagagct tgcagcgaac 1426261 atcggtactc ctgatgatgt aaaaggtgtt cttgaaaacg gcggagaagc agttggcctt 1426321 taccgtacag aattccttta catgggaaga gatcagctgc ctacagaaga tgagcagttt 1426381 gatgcttaca aaacggttct tgagcgtatg gaaggaaaat cagtcgtcgt gcggacactt 1426441 gatatcggcg gagacaaaga gcttccttac ctgcagcttc ctaaagaaat gaacccgttc 1426501 ctgggatata gagcgattcg tctttgcctt gaagagcaag aaatcttcag aacacagctt 1426561 cgcgcgctgc ttcgtgcaag tacatacgga aacttgaaaa tcatgttccc tatgattgcg 1426621 acagttaacg aattcaaaga agcaaaagcg atccttcttg aagagaaaga aaagctcgta 1426681 aaagcgggac aggctgtatc tgacgatatt gaagtcggaa tgatggttga gattccgtca 1426741 actgcagtca tcgctgatca gtttgctaaa gaggttgatt tcttcagtat cggaacaaac 1426801 gatttgattc aatacacaat ggcagctgac cgtatgaatg aacgtgtatc ttacctgtat 1426861 cagccataca acccggcaat ccttcgctta attacactgg taattgaagc agcacacaaa 1426921 gaaggaaaat gggttggcat gtgcggagaa atggcaggag acgagattgc gattccgatc 1426981 cttctcggct taggcttaga tgagttctca atgagcgcaa cgtctatcct tccggcaaga 1427041 acacaaatca gcaaattgtc taaacaagaa gctgagtcat tcaaagagaa aatcttatct 1427101 atgagcacga cagaagaagt tgtcgcgttc gtaaaagaaa cattcaagta atgtacaaaa 1427161 accagacggc ctccggcctg tctggttttt ttcataagta agggtataga aggacacaat 1427221 aacatggcta ggagggatag tatgtcaaac caatttaacg caggagatac tgtttatgtg 1427281 atctacagaa atccgcacgc cgccaatgta gcccacataa aggaagccga aattgtgcac 1427341 catccatacc atgaaggcga gctttccctg tttatttatg aaacctatca tccattcgca 1427401 gaggacgatg ctgtgtttgc aagctatgaa gaagctaaat cgctttacaa agaactgttt 1427461 gatattgatc cgtatgagta acaaggaaat cattacaact catatccttt ccgcctagtg 1427521 agaaaagtaa cgttagtaaa ggaaaaggat gtggcatcat gcagaaccca tttgttccgc 1427581 agcttgtgta tatagaaccg agggcgctgg aatatccgct gggccaagaa ttacaagata 1427641 aatttgagaa tatgggtatt gaaatcagag aaacgacatc ccacaatcag gtgcgtaata 1427701 tccctgggaa aaatcatctt cagcaatatc gcaatgcgaa atcaacttta gttatcggtg 1427761 tccggaaaac attaaagttt gattcatcca aaccctcggc cgaatatgcc attccgtttg 1427821 caacaggctg catggggcat tgtcattact gctacctgca aacaaccatg ggatcaaagc 1427881 cgtatatcag aacttatgta aacgtcgaag agattttaga tcaggcagat aagtatatga 1427941 aggagcgcgc accagagttc acaaggttcg aagcatcatg tacgtcagac attgtaggaa 1428001 ttgatcatct gacacacacg ctgaagcgcg ccattgaaca ttttggccaa agtgatctcg 1428061 gaaagctccg atttgtaacg aaatttcatc atgtcgatca cctattagac gcaaagcata 1428121 acgggaaaac gagattcaga ttcagtatta atgccgacta tgtgattaaa aactttgagc 1428181 cgggaacttc acctcttgat aagcggatag aagcggcagt aaaagttgca aaagcaggct 1428241 acccgctagg ctttattgtt gctccgattt atattcatga aggctgggaa gaaggataca 1428301 gacatctgtt tgaaaagcta gatgctgctt tgccgcagga cgttagacat gacattacgt 1428361 ttgaattaat tcaacaccgt tttacaaaac cggccaaacg agtgatagag aaaaattatc 1428421 cgaagacgaa gctcgaatta gatgaagaaa agcgccgtta taaatggggc cgttacggga 1428481 tcggaaaata tatttatcag aaagatgaag agcatgcact tcgagaggca cttgaatcct 1428541 atattgatac ctttttccct aacgcaaaaa ttgaatattt cacttaaacg ggctgttgtg 1428601 atcaacagct cgctttttta taaaaaacat ttttccattc catcaaaacg ccgtaattca 1428661 atgattcttt atcctccaaa taattgctga ctacacgaat aggtgaacgc ccgcaacgga 1428721 ggagaaagga cagcacaggg tcgtttttcc tgccttccat cacatcttca acgtactgaa 1428781 cagcgctgat ctcgtgtgcg tatttataat acaaaggaat gcggccgccg ccgagaaggc 1428841 gttccagtct tttatcaaca gtcagctcat acatcgtatt catcagccat tttccgattc 1428901 caagctttcg ataatgagga gaaacagaaa tatccactac atataaagta tttccatgag 1428961 gttcatgatt tttaatcgat ccgttgtcag ttgcttgtgc ccatgtatga tcaggagaat 1429021 caggctcaaa ttgtacaata agagcagtca tggaaccgat aattctgcca ttgatgagcg 1429081 cgcataaagc gccttccgga aaggttttga tatggctggc aagctggtcc tctgaccaca 1429141 gcaattcctg gggaaacgga ggagggaaac attcttcttg aagagaaatc agcctctcga 1429201 tgtcagtctc agtgtagttt ctaatggtca gagcctcaaa ttttctgccg tcatgcacat 1429261 acatttgttt tagtatgatc atcactctcc ttatgttgtt tcattataac gaagattgaa 1429321 ttttcagtaa atatattccg attttcttat aatttatttt ttgattattc atttttcaaa 1429381 cgaaagggcc gatatagaaa ttaggagggg attggtttgt ttaaaaaact tcacatgaag 1429441 attgctgttt ttgtttcgat tatgttaatc atcacagttg ttctcttaat gctgtcttct 1429501 tatttgacgc taaaaccgat gattacagag gatgggaaaa atacaactca aaacgtgacg 1429561 cagtcacttg aacaaaatat tgaattgcaa ttaaagagtt atgccatttc gttatcaaga 1429621 ttggctaatg gggaattaac gcatacattt gtaacgaaac caagtaaaga agcttctcgg 1429681 ctgtttcacg atgacattaa gcaaatcaaa gacaacgatg attatgttgc gatggcttac 1429741 ataggcaccg caaaaaaaga aatgtttaca tatccaaaag cggatttcgc tgaggattac 1429801 gatccaacat caagaccatg gtataagctt gcagctgaaa ccccggatca agttgtttgg 1429861 acggaacctt ataaagatgt cgtgacagga gacatgattg ttactgcatc gaaagcgatc 1429921 ttagacaggc aaaaagtgat aggggttgcc agctatgact tgaaactctc tgctatccag 1429981 agtatggtca ataaacaaaa ggtgccttac aaaggatttg cctttttagc tgatgcgagc 1430041 ggcaatcttt tagcccatcc gtcaaatcaa ggaaaaaata tatcaaagga tcaaacactg 1430101 caaaccatcg catccgagaa aaaagggata caagatgtga atgggaaaat ggttgtgtac 1430161 caaacgattg gcgagacagg ctggaaggtc ggaacgcaat ttgataccga tcaattaatg 1430221 tggatttcag ataaaatgaa tcgggccaat ctttggatat cattgattgc gcttatcata 1430281 acaattattc tcagctactt cctggccaaa acgataaccg gtccgataca gcagctgatc 1430341 gtaaaaacga aagctgtttc cgcaggcgat ttaacagtgc gcgcggaatc aaaatctaag 1430401 gatgaagtcg gtattttaac aagagatttc aatctgatgg ttgaaaatat gaaggaaatg 1430461 gttgagcaag tgagactctc ttcagggaaa gtatctgaca cctctgaaca actaacggct 1430521 gtggctgccg aaactaatga aacaagcgga caaattgcaa aagcgattga agaagtagcc 1430581 gcaggggcat cggaacaggc ttctgaagtt gaaaccatta atgaaaaatc ggaaagcctg 1430641 tcaacgaaaa tcaggcaaat cgctgaggag gcaggcggaa ttaaagaacg ctcaaaatcg 1430701 tccgaggatg caagctataa aggacttgac gcgctcggcc agctgctgat gaaatcaaac 1430761 gaagccaata tggaaacgaa aaaggttgaa acgatgctgc tggatttgga aaatcaaact 1430821 aagaatattg aagaagtcgt tacagcgatt tcaaacatat ctgatcaaac caacttgctt 1430881 gccttaaatg ccagtattga ggcagccaga gccggagaaa gcgggcgcgg ttttgccgtc 1430941 gtagccgatg aagtgcggaa gttagctgag caatcagccc tttctacaaa gcatatcagc 1431001 gagactgtga agcttatcca gcttgagaca aaagaggcct ctcacgcgat ggttgaggca 1431061 agcagaatga atgatgaaca aaacagtgca attcacgaaa ctggagaggt attaaatacg 1431121 ataactgcag aaatgcagtc actggtacaa ggtattgatc acatttacgc ggaaattcaa 1431181 agaatgagtg aagaacagct tgcgatttct gaagccattc aaagcatttc agccatatca 1431241 caggaatcag ctgccgcagc agaggaagtg aacgcatcaa ccgatgaaca gcttgtcacc 1431301 cttgataaag tcaaacactc aacggaaaca ctaaaacatg caagccaaga gcttatgaac 1431361 acaattgcaa aattcacatt gtaatccaat tacatcccca aacatcattt gttttgggga 1431421 ttttttattt tataagatga atagatatgg tagtctagaa aatgaaggaa aaatgataaa 1431481 ttttaactaa aatctaaacg aaacatctgg gaggaatgac cttgaaaaaa acaattggtt 1431541 ttatcggtct tggagtaatg ggaaaaagca tggcatcaca tattctcaat gacggccatc 1431601 ctgtattggt gtacacccgg acaaaagaaa aagcagaaag catacttcaa aaaggcgcga 1431661 tctggaaaga tacggtcaaa gatctttcga aagaagcgga tgttatcatc acaatggtcg 1431721 gctatcccag tgatgttgaa gaagtgtatt tcggaagcaa tggaattatt gaaaacgcaa 1431781 aagaaggtgc atatcttatt gatatgacga catctaagcc ttcgcttgcg aagaagattg 1431841 ctgaagcggc caaagaaaaa gcattgttcg ctttagacgc tcctgtttcc ggtggagaca 1431901 tcggtgcaca aaacggaaca ctcgcgatta tggtcggtgg agaaaaagaa gcttttgaag 1431961 cctgcatgcc gattttctct ttaatgggag agaatattca gtatcaagga ccggctggaa 1432021 gcggacagca taccaagatg tgcaatcaga ttgcaattgc agccggtatg atcggtgttg 1432081 ctgaagcgat ggcttatgcc caaaaatcag gcctagagcc ggaaaatgtt ctgaaaagca 1432141 tcacaacggg cgcagccgga agctggtcat tgtcaaatct tgctccccgt atgctgcaag 1432201 gcaactttga accgggattt tatgtgaagc attttattaa ggatatggga attgcactag 1432261 aggaagcaga attaatgggg gaagaaatgc caggcttgtc gctcgcaaaa tctttatatg 1432321 acaagctagc tgctcaaggt gaagaaaaca gcggaacaca gagtatatat aagctttggg 1432381 tgaaataaaa aaagattgcc tgtacgaaac aggcaatctt tttttattat tttccgatga 1432441 attgttgtgt ccagatgctt ccagactcaa cgtaaccaac accgatgtga gtaaagttag 1432501 ggtttagaat gttttttctg tgtccttcac tgttcatcca agcttttact acttcttctg 1432561 gtgtcttttg gcccttcgca atgttttcac ctgctgtttt gtagctgatt ccgaaagatt 1432621 tcatcatatc aaacggtgag ccgtatgttg ggctttggtg atcaaagtag tttttgtctt 1432681 tcatatcctg agattttgcg cgtgcagatt tgcttaacgt ttcatcaatt tgaagcggtt 1432741 ttaagccttg tttttgtctt tctgcatttg taagttcaac aacttttttc tcatatgcac 1432801 ttacagatga aggtgcagac gttgttgtgt ttgttttttc agcagttgcg ggtgctttag 1432861 aagcagtgtt ttgatcagca gctgcttttt cagtagtctt ttgtgcaggt tttgccgttt 1432921 ctgtcttttg aacatcctga actttcacgt tagattgctt cgcatgtttt tgaagaagct 1432981 gcttcatctc tttttcgttt gcagcgttta acgttttgat atttgtgtta atatgcagtt 1433041 ttttcactgc atcgttaagt gacatgtttt gtactgtgtt ccccgttttt actgtaacca 1433101 caggctggca ggagagttct ttcgctgatg cttgctgtac gcccccgaat gtgaataatc 1433161 caaccgcagc ggcagcagat aaaataaatg ctttcttcat tagttcgtaa cctcctagag 1433221 ttgtttgttt ctacagaaaa atcataacat agcttttttg tcataaagat tccagcactt 1433281 tcctttgaca aatagagatt gtcattttcg taaagtaaat ccgttgaatc actaagaata 1433341 agggaatcag cggtatatat gattttatcg taccgttaca tagcttcctt ttttttgaac 1433401 cgttagttat attttaatgt gtttttatat tgacagcttt ttttactcct tttcgctgta 1433461 acaactatta caaaggtgtt acaattaatc tcagtatatg taaatatatt gaatgatttg 1433521 agaggggtaa ccagaagtga ctgaaatagg acgtgaacca aagaaaaaga gcaaaggaaa 1433581 cagagcaatc agaatgaacc tttttttcct agctgtcttt gttctattca ctgcattaat 1433641 ttttaagctc ggggttgttc aaattgttga aggcgaacag catgaagaag acgctgagaa 1433701 atcaaatgca aaaacagctt actatcctgc gcctcgcggg aagatgtacg acagaaacca 1433761 gaaagttgct gtcgacaacc agagcgttcc agaaattgtg tatgtatcaa catctagcac 1433821 aaaaacagaa gataaaatca aaacagcgaa gcggcttgct tctttcattc atattgatac 1433881 cgaatttttg aaggaaaggg atcttcgtga ttactggatc gcagctcatc cgaaaaaagc 1433941 cgccgctctg cttaaggaat cagaaagcaa tctgaaagga gaccaggctt acaagcttca 1434001 aatagagcgt gttccggatc aagaattaaa ggctattcag caagatgacg aagaaatgga 1434061 aactgctgcg atatatacaa ggttttcaag cggaaatgct tacgaacctc aaatcgtaaa 1434121 ggcaatgaat ccaaataaga gcaatagcaa tggaaaaaac ggagcgctgc ttgatgagaa 1434181 gaaaaactcc tcgcaaagac caaaaaatga cttaacatat gatgaaattt ccattgtttc 1434241 tgagcattta gaagaacttc cgggaatcga tatcgtaaac gattggacac gaaaatatcc 1434301 ttatgacaaa accctttatt ctgttttcgg gggcgtcacg acacctgatc agggcctgct 1434361 gagcgaccgg aaagatttct acttaacaag aggctatgcg aataatgaca gggtgggaaa 1434421 aagttattta gagtatcaat atgaagaata tttaaattcg cataaagaaa aagtggaata 1434481 cgtagaagat aataaaggaa atgtcgtcag ccaaaaaacc attgataagg gcagcagggg 1434541 atacgatctt cagctttctt ttgacatgga gcttcaggca aaggtagaaa agatcattga 1434601 agaagaagta agaaacagcc gtgcacgcgg aaattacatg cttgacagag cctttgccgt 1434661 aatgatggac ccgaataacg gcgatatttt atcaatggca gggaaaaaga tagatttaaa 1434721 aaccaacaaa attgaagatt atgcgatagg ggcatttacc acccaatatg aaatgggatc 1434781 agcagtaaag ggggccaccg tgctagccgg ctatcaggac gggatcccgc attataaata 1434841 ttatatcgat gctccaatgc ttttaggaac gaatcttata aaaaaatctt atactaatat 1434901 gggaaccatc aatgaattaa ccgcattgca aaaaagttca aacgtatata tgttcaatgt 1434961 tgccatgcat attgcaggcg taacatacaa gccgcatgga tctctcccgg ctgatcagaa 1435021 cgatctactg aaaatgagaa actattacag ccagtttggt ctgggagtaa agacaggtat 1435081 tgatctcccg caggaatcag ccggaatgca aaccacacct aaaactgtag gaggattaat 1435141 tttagactta gcaattggcc aatacgatac atacacaccg cttcaaatgg ctcaatacat 1435201 ctcagtaatc gccaatggtg gctatcgtgt tcagcctaga atcgtcacaa gtattcataa 1435261 gccaggaaaa aaagaccagc tgggtaaggc gattgaacat aggaaaccta aagtactcaa 1435321 taagattaat aattcagaga gcgatttgaa acaagtacaa acaggcatga aattagtcac 1435381 ttcttcaggg acagcaaaaa atacgtttac agaagatgta tcagggaaaa cgggaacagc 1435441 ggaaacattt tactacggca cgaatcgcaa ctggtggggg aaaaaaacat acaatctgac 1435501 ttttgtcggc tattacccgt cgaaaaaacc aaaagtggcc tttagtgttg ttgttccatc 1435561 agtagatgat gatgataaga tcaataaaat tattgccaaa agagctatcc acgcctacgc 1435621 agagctcgaa aaaaaacaca gtaaaaaata aaaaacaggg tgcacaacta aaagattgtg 1435681 tgccctttct tttattcaaa aattgacgtt caccataaga atagaaggag aatactcatt 1435741 ttctagcgaa tcatactagg taaaagtcaa tctgtatatg tcgaaacacg atgatcatgc 1435801 aaaggaggga ttctgtggaa caggatacgc agcatgttaa accacttcaa acaaaaaccg 1435861 atattcatgc agtcttggcc tctaatggac gcatcattta tatatctgcc aactccaaac 1435921 tgcatttggg ctatctccaa ggagagatga tcggatcatt cctcaaaacg tttctgcatg 1435981 aggaagacca atttttggtt gaaagctatt tttataatga acatcatctg atgccgtgca 1436041 cctttcgttt tattaaaaaa gatcatacga ttgtgtgggt ggaggctgcg gtagaaattg 1436101 ttacgacaag agctgagcgg acagaacggg aaatcatttt gaaaatgaag gttcttgaag 1436161 aagaaacagg ccatcaatcc ctaaactgcg aaaaacatga aatcgaacct gcaagcccgg 1436221 aatcgactac atatataacg gatgattatg aacggttggt tgaaaatctc ccgagtccgc 1436281 tatgcatcag tgtcaaaggc aagatcgtct atgtaaacag cgcgatgctt tcaatgctgg 1436341 gagccaaaag caaggatgct attattggta aatcgtccta tgaatttatt gaagaagaat 1436401 atcatgatat cgtgaaaaac aggattatac gaatgcaaaa aggaatggaa gtcggaatga 1436461 ttgaacagac gtggaaaagg cttgatggca cacctgttca tttagaagtg aaagcatccc 1436521 cgaccgtcta caaaaaccag caggctgagc tgctgctgct gatcgatatc tcttcaagga 1436581 aaaaattcca aaccatcctg caaaaaagcc gtgaacgata tcagctgctg attcaaaatt 1436641 ccattgatac cattgcggtg attcacaatg gaaaatgggt atttatgaat gaatcgggaa 1436701 tttccctgtt tgaagcggct acatatgagg atttaattgg caaaaacata tacgatcagc 1436761 tgcatccttg cgatcacgag gatgtaaaag agagaatcca aaacattgcc gagcaaaaaa 1436821 cagaatctga aattgtcaag caatcctggt tcacctttca gaacagggtc atctatacgg 1436881 agatggtctg cattccgacg accttttttg gtgaagcggc cgtccaggtc attcttcggg 1436941 acatctcaga gagaaaacaa acagaagaat tgatgctgaa atcggaaaaa ttatcaatcg 1437001 cagggcagct cgcggcggga atcgcccatg agatccgcaa ccctcttaca gcgatcaaag 1437061 gatttttaca gctgatgaaa ccgacaatgg aaggcaacga acattacttt gatattgtgt 1437121 tttctgaact cagccgtatc gaattaatac tcagtgaact gctcatgctg gcgaaacctc 1437181 agcaaaatgc tgtcaaagaa tatttgaact tgaaaaaatt aattggtgag gtttcagccc 1437241 tgttagaaac gcaggcgaat ttaaatggca tttttatcag aacaagttat gaaaaagaca 1437301 gcatttatat aaacggggat caaaaccaat taaagcaggt attcattaat ttaatcaaaa 1437361 atgcagttga atcaatgcct gatgggggaa cagtagacat tatcataacc gaagatgagc 1437421 attctgttca tgttactgtc aaagacgaag gggaaggtat acctgaaaag gtactaaacc 1437481 ggattggaga gccattttta acaacaaaag aaaaaggtac ggggcttgga ttaatggtga 1437541 catttaatat cattgaaaac catcagggag ttatacatgt ggacagccat cctgaaaaag 1437601 gcacagcgtt taaaatttca tttccaaaaa aataaaaaca acggcttaaa cgccgttgtt 1437661 tatcgtctgc attgcttcac gtttttttaa tacaaataat tctaaacggt ctaggccttc 1437721 tctcagcgtg tccattgagc atgcaaaaga cagccttaca tatccttcac catatgttga 1437781 gaacgagctg cccggcacga gtgccacgcc agcgtcttcc aaaagagcca tactaaaatc 1437841 aaatgaagtc attccaaatg atttaataga agggaagata taaaacgcac cggacggttt 1437901 aactacgtca agtcccatgg aaacaagacg gtcataaaca tagtccagac gttttttgta 1437961 ttgttctctc ataatcaatg catcgtcaaa gccgtttgtg acagcttcaa gcgcggcttt 1438021 ttgagaaatg gatgaggcgc acgacacatt gtattgatga acctttaaaa tgtgctttgc 1438081 aatgtctttc ggtgcaaata aaaatccaat tctccaaccg gtcatgctgt gtgattttga 1438141 caacccgtta atgacaatcg tttgatcccg caaataggtt gcgatggagt aatgcggtct 1438201 gtcatatgtt aattcactgt atatttcatc agacaatacg aagacatttc tgccttttaa 1438261 gagagctgcg atgcttttca gttcttcttc agataaagtc acgccggtag ggtttgacgg 1438321 ataaggaagc acgacacact tggtgttggg tgtcagagca tcttcaatca gccgggcggt 1438381 aagcttaaag ccgtgtgacg tagtatcaac aatgacaggc ttggccccgc acaaattgat 1438441 aataggttca tagcccggat aaataggccc tggcataatg acttcatcac cgggagataa 1438501 aatcgtccgg aatgcagcat caatggcttg gcttgcgcct gttgtgatga taatttcaga 1438561 ttcagcatca tagttgaaat ccgctttttt cttcatataa agctgcacag cttgtctcag 1438621 ctccaggtag ccggcattcg gagtatatga cgtcacgttt tcatcaatgg ctttttttgc 1438681 ggcagctttc acatgatgcg gtgtgaaaaa atcaggctgg ccgattgtaa gtgaaatgac 1438741 gtcttcgtgt tgggctacaa gattcgagaa tttgcgtatt cctgaaattt cgatctctct 1438801 tgctttcgga ttcagcaaat gttccataat tcatcacctt aacaaatata atgagtttat 1438861 cctattttac cactagctga tcatttgtca cctttttaac tgatatattt cgattgtatg 1438921 cgcctttttt ctaaacatac ctttcttttc agaaaaaaag aagacaacca gcgatttgat 1438981 tgtctttatt gtatcatgtt ctattattgt ttatatgtgc caatttcatt aatagccata 1439041 atcaaaatga aggtcttcgt gccaaatcag atacggagga tgctcttctt gaaggtcagc 1439101 tgattctttc ttcatattca ggtaagtttc ttcactgata tcctctaaaa cagtcatttc 1439161 gttttcttta aatattacta aggtacccat tatttacacc cttctttgga aaaatccttg 1439221 actattttat cactgttagt tggaaagtca atggttatta ggaaaaaagt ttcttttttg 1439281 aggaacgcgg cttgttgcct tcggaattcg attttgaaga gctgccattc actttttaca 1439341 aattacgccg atatatacag tacaatactg aatgcgaata gcgagggatt gaattgtcgt 1439401 tacaacaata cgaaatttta ttggattctg gtacaaatga attagaaatt gtgaagtttg 1439461 gcgtgggtga aaatgctttc ggaattaacg tcatgaaggt aagagaaatt attcagcctg 1439521 tcgaggtgac atcagtgcct cactcccatc agcatgtaga aggaatgatt aaactcagag 1439581 gagaaatcct ccctgtgatc agtctcttct cattttttgg agtagagcct gaaggatcaa 1439641 aagatgagaa atatatcgtg actgaattta ataaacggaa aattgttttt catgtcggct 1439701 ctgtttctca aattcacaga gtatcctggg aagcgattga aaagccgaca tcgttaaatc 1439761 aaggaatgga gcggcacctt accggtatta ttaagctcga agacctgatg atctttttgc 1439821 ctgactatga aaaaattatt tatgacattg aatcagattc aggtgttgac acgtataata 1439881 tgcataccga gggcttcgat gaaagaagaa ctgataaaaa gcttatcatt gtagaggact 1439941 caccgctttt gatgcgcctc ttgcaggatg aattaaaaga agcagggtac aacaatatcg 1440001 cttcgtttga aaatggaaaa gaggcatatg aatacattat gaaccttgct gaaaacgaaa 1440061 ctgatttatc aaaacagatt gatatgatca tcactgatat tgaaatgcca aaaatggacg 1440121 gacacaggct cacaaagctg ctgaaggaaa atccgaaaag ctcagatgtg ccggttatga 1440181 ttttctcatc gttaattacg gatgatctgc gtcaccgcgg cgaagttgta ggcgcagatg 1440241 agcaaatcag caagcctgag atcagtgatt tgattaaaaa agtggatacg tatgttattg 1440301 aataaataaa aacagccgtt gccagaaaga ggcacggctg tttttatttt aaaagtaact 1440361 ctcgccaagt tttttaaaga ccggtttatg gtaagctggc tgctggcgat ttggcactag 1440421 cggcttttct ttcatgccga catattcttg caataggtgt ttcgcttttg ttaaagacat 1440481 ttgagcttta ggatttcgat acgattgatt aagtgtacct aaatgcggaa gatgttcgaa 1440541 gtcttcttta gttggaggca tgtgaaaata gtagtctccg attgagataa gcacgtccga 1440601 ttgctgttgg ctgaaccttg gattttttga aaaatgaagc cctattttct ttcctttacc 1440661 ttctttgaca agcttttgca aagcccgttt tttcagcaga tataggtatt tagggttggg 1440721 ggcggttttt gcatggcggt tcacagtgta aactgctttt gaaagatttt ctacggttgg 1440781 ctgcagatct ttcgtatatg catggtcgtc cattatttct ctcctttgct cttatcaatt 1440841 tctatatgtt tagattatac ttttttaaag ttgaaatgca aatattgaat gtaaaaatgc 1440901 gcttttttct aagaaaaaaa gcgcattttt aacctgcatt atacagatct tgccttcttt 1440961 ttcggctgtt cttgaaatgc ttcctgaaca ttcacttcca cagcctgagc actgtatttt 1441021 ggcagtgcaa taaaataaaa aataaaaacg agcaggataa taacacccat gccgtaataa 1441081 agataatcaa tgtttgaaac aaacttaggg aataacagcg cgactaagcc gagtgtcaaa 1441141 gattgtgcaa acatcataaa agggtcctgc atgccgctta cacgtcccat cagttttgga 1441201 tgaacaattt ttggcatcca ccctccgatt gcaatgttga tcggtccgat acacattccc 1441261 agtgcaaaag ctgccgcgta atacacccat aaaatattgg tgtagccgag gacgaagatc 1441321 agcaaacctg caatgaaaat cggtatcgac attaaaaagt gcggcttcac ttttttagag 1441381 atgagcgtgc cgattacgct tcctgccaga agcccaaacc cgagtgcgat cgtaaataca 1441441 gacgtatgcc actcataacg gtcaggcgcc aatccatatt tcattgtaaa catcggcaat 1441501 acggcgaatc ctccattgac aaatccaaaa atgaagaagc caaaaataag agatgccagc 1441561 aatttgtttt ttaaaatata gaggatgcct tctctaaagt catttattga atccttaaca 1441621 gaagtctttc tccagctgaa tgcaccgttt ggctgtcggg cttcttttgg aatccggcag 1441681 ctgcggatca gcagcccgga aatgataaag ctgacaaaat caagaataat ggcgccttca 1441741 ataccgattg tgttgtacat aaacgcgcct atgccgactc caaacaccat aaaaatgcta 1441801 aaaagcatct gattaagccc tgccgctttc gcataatgct ccttcggcag aatggcttgt 1441861 accaaactgt tttctgccgg aaagaaaaac tttgttacag cgcttctgat aaataagata 1441921 caaaaaacaa gaggaatatt gccggtaaat aaagtgaaaa aaagcacgac agtcaggcct 1441981 gctctgatcc aatcacaatt ttctgccacc ttttttctat caaaccggtc cgcgacgact 1442041 cccacgatca gaaatacaaa tatggtcgga agagaataca tcagctccgc caaggtcgta 1442101 tatgaaggct ggctgctgaa tcggtccagc aaaaaaaaag caaaggccat gttgcctact 1442161 gtcgtgccca tttgagaagc gagtgctgcg aaaaatagac gaacaaaatt acgattttta 1442221 aatatatcca taaaaacgct ccttacccta aaggtcccac tttatcatat tataaaccgc 1442281 ctgtttttga aacaaataag aaaacattac cggttaatcg tgactctcgt tccgtttggc 1442341 acaattgaag caagttcgat cacgtctttg ttatgcatgc gaatgcagcc tttagaaaca 1442401 gccttaccaa tcgaagcggg attattcgtc ccatgtattc cgtagtgctg ctttgaaagg 1442461 ctcagccaat aagcgccaaa tgggccgccg ggattgcgct ggcggttaat aatgtaaaac 1442521 tcgccagtag gcgtttgcgt tagtatttta ccaacggcga tgggataggt tttcattacc 1442581 cgattattta gggacagcgt aagggtcttc gctccgattg agactgcgat atgatacgga 1442641 attgtataag ggtccggcag tccggggatg actatggact gtcccgcggt gagccctgcc 1442701 tgcagtgacg gattagcctg gagtaatgca gccgtgctga ttctgaaatc agccgcgatg 1442761 ctgttcagtg tatcaccttg cttcacctgg tacgtaagca gtttcctcat cctccttttt 1442821 tacttataag tattgatgag gagcccatcc tgctacatta atttgtgctt tttaaggtga 1442881 agacagtgat ttcaggcttg gcaagaaacc gcaaaggcag cctggtcatc ccgaggcctc 1442941 ggtttacgta aatatgagtg ctgcccgttt gatacattcc ctctgtgtag acttttccat 1443001 atggaggcgt aataatcggt ccgtaaaaag gcagctgaat ctggccgccg tgtgtatggc 1443061 cggaaagctg aaggttcacg ggataatctg ttgttttcaa ggctgcatca ggttcatgga 1443121 cgagaagaat ggaaaaaagt ctgtcgctca gccttgaaag ggtgccttca taatctgggt 1443181 ttcccagcat taagtcatca agcgaagcaa tctcgatttt gctgccatct gcgagtgaca 1443241 atgtttgata gccattgcga tataccgtga aacctccggc cgtcatcagg cttttgtaaa 1443301 cggcagttcc atagcctccg tgatcatgat tgccgtaaat acaaagcttg ccgaagggag 1443361 cattaagctt tctcaataat ggaatgactg cctggtggtg ctggtacgta tcaggattat 1443421 caataatatc acctgtaaaa acaatgagat caggtttaga ttcattaatt gtaagaatga 1443481 cagtttttaa atcttcgaga gtaaagtaat cactcaagtg tgcatcgctg aactgcacga 1443541 ttttaaaacc gtcaaatccg tgcgggatga gagagctttt tattgtgtgt tcggttgtct 1443601 cgatcatatg cggctcgaga tacctggcat agccatatcc cccgccggcc gttaaagccc 1443661 cggcagcaag agcgccgaac attcctttta gaaattgtct tctggacatc tttttcattt 1443721 caaaccaacc tttaatagag tttttctatt atatcatctg tatctgataa aaatctcata 1443781 tgagcatgtg ctgacagagg cagggatata atgatagaat attattgaat gaataatcat 1443841 tcacaattgg agggataaac atggaaaaaa aggcggtaat tattaccggc gggtcaagcg 1443901 gcatgggaaa agcgatggca aaaaaacagg ctgaattagg gtggcacgtt atggtgacag 1443961 ggaggaacca tgaggcactt gaggaaacaa aaaaagaaat tcagaccttt gagggacagg 1444021 tcgcttgttt tcaaatggat gtccgttccg attccgccgc ttcagacatg attaaagaag 1444081 cggtaaaagc ctttggccgg cttgacgcgc tgattaacaa cgcggccgga aactttattt 1444141 gtccggcaga aaagctgacg cccaatggat ggaaagccgt tattgagatt gttttaaacg 1444201 gcacattttt ttgcagccaa gcagcggcaa ggcattggat tgaccagaag cagcagggtg 1444261 tcattttaaa tatggcagcc acgtacgctt ggggagcggg agcgggggtc gttcattccg 1444321 ctgcagccaa agcgggggta ttgtcattga caagaacgct ggccgttgaa tgggggagca 1444381 aatacggcat tcgtacaaac gcgatagccc ccggaccgat tgaacgaaca ggcggtgcgg 1444441 agaagctatt tgaatcggaa aaagcgatgg cccgcacgat gaacagtgtg ccgctcggcc 1444501 gattgggcac accggaggaa atcgccgctt tggcagcgtt tttgctttct gatgaagcat 1444561 cctatataaa cggggattgt atcacaatgg acggggggca atggctgaat ccttatccgt 1444621 tttaatctga atatttataa gtgaatattt aagttattaa gaacttttat gttcgaatgt 1444681 aatacctcca caattaacct tcttcctatc caatttgata acacatagag ctttatttgt 1444741 ttatgaggtg ttgtgtcata cgtaagccac ctaatatatg aaaggtatat tttaaaaggg 1444801 gagacgaaat atgaagaact tagatttcaa ataaaacatt catataatta cttcgttaac 1444861 taaaaagaga aattataaga atgaaaggtt tcaaggttac atcagattgg gaggaaggta 1444921 atataatgga cgagatggta ttattaactc aggaatggct caatgaaacg tacaaaggaa 1444981 aaagtggcta caattccatt gaggaaaatg ggaaaactgg ctggaaaaca atgtatgcat 1445041 taactagagc attacaacta gaattgggaa ttacacagac ttccgacagt tttggtccta 1445101 caactttaag aaagcttaaa gaattaggcc cgatttctac gtcaactaat tcaaaaaaaa 1445161 atattgtgaa aattattcaa ggtgctcttt attgtaaagg ttatggtcca ggtggattaa 1445221 cgggtacatt tggtcaggga acgaaagagg cgatagcaga aatgcaattg catatggggc 1445281 tttctaaaac agacggtgta gtaacgccta aggtgtttaa agctttatta aacatggact 1445341 cttatatcct tttaaatggg gcgtcagaga aagttcgttc aatacagcaa tggctaaata 1445401 ataaatatta caatagagag aatttctact ttatgccctg tgatggcctg tattcaaggg 1445461 atactcaaaa gtctcttgtt tatgcaatac agtacgagga agggttaagt gatagtatag 1445521 ctaatgggaa ttttggacca actactcaaa gattgattcc tgtattaaga attggagaaa 1445581 cagatgaaaa aaacagtttt attcatttat ttcaagctgc tctaatcttt aatggctaca 1445641 atgttccttt tgatggagta tactctgaat ctgtaagatc aaaagtaaag gcttttcagt 1445701 cttttgcaaa attacaacag agtggtactg ccgactttca aacatgggct tcacttctag 1445761 taagtactgg agaccccaat cgaaaaggag ttgcttgtga ctcaattact caaattacat 1445821 cggacagggc ggagtccctt aagagggcag gttataagat tgtagggcgg tatctaacaa 1445881 atgcgccggg gagtacacta aataaaaaaa tacaaccagg tgaattagaa actatcttaa 1445941 aatcaggttt aaatgttttt ccgatttatc aaacctatgg gggagcaaca aattatttta 1446001 ataaagaaca aggaaagaaa gatgcgtttg ctgcttataa agcagcaaaa gaatacgggt 1446061 ttaaaaataa cactgtaata tactttgcag tagattatga tgcatatggt aacgatttaa 1446121 acaacaatat tattccacac ttcgaaggta taaatgaaat aatgaacggt tttttaggtt 1446181 caacttacaa aattggtatt tatgccccta ggaatgtatg tactatagtt tctaaaaaag 1446241 gtttagcatt tgcaagtttt gtaagtggta tgtctactgg ctttagcgga aacttaggat 1446301 atcctttgcc ttacaattgg gcgtttgacc aaatttcaac aattactgtt ggaaatggtt 1446361 ctggaatgat tgaaattgat aatgatattt gttcaggttt ggataatgga gttaatacca 1446421 taaatatagt gccttcagag aataagaagt tttttgatca aattgatgtt ttatatgaaa 1446481 ctgctgaaaa atatgctcaa atgcaaagcg acttaaataa tggggtaaaa aaaacacaat 1446541 tagctaatga gttggttgcc cagtatttaa gaaaggatga ctacaaaggg tggaagtggg 1446601 tccctaccgc aggccagatt gatcctattt atcgtgaatg ggcagtaaag cgctagggga 1446661 agacctagta aatggaattg ttgatcctat atcaaaaact gtcataggaa cgcagcatct 1446721 tatggcaact tataatgcca ttatttatag tggtggttac tctcaaacac tacgagattt 1446781 tgctggttgg actggagatc tattaacaac aatacaggac atgaaattac acgctcaaga 1446841 atttaattcg ccttatgatg cggctatgaa aataataggt aatatgtatc aatttagcct 1446901 agatgattta tttagtgatg tagatgcaat taatctagcg aataaaacat cagttggtgc 1446961 taatgcacaa cctctaaata tcgcaattag agattattat agtaataatg actgtatgaa 1447021 taggttcact caatttgtaa ataatagatt tgatggttcg ttagacaaaa ttttctctga 1447081 agcagagtat tatttaaata caaaccttga cccagttgtt gttccaatta ggttagcctt 1447141 taaacgtgct tttgatgttg aggattatag tgaagagatt ggaaaaataa cagcacaagc 1447201 atttagagat gttatcgaga aaaaaatgat atctgaataa actgcaaaac aagcgaacgt 1447261 taaaactggt cgttcgcttg ttttattttc tatttaaatt tatgatataa tttttaaaga 1447321 ttaaggagtg attcattgaa gaaattgtta aaaaagttag ttgtattatt tttaagcagt 1447381 ttagttatca tctttaatgt ttggtacttt attatttgtg ctttttcccc agagtattat 1447441 caaaatacaa atcttacttc taatgaaata ataagatttg aaaaactata ccacatagat 1447501 tttcctgatg aaacaaaatt tattaaagct agagagtatt tggctgggcc cggaggagat 1447561 acgtcagctg tattatatgt gtctctgcca accaagcggg tagaaaaagt tttatctgat 1447621 tacacgtata tgaaaataaa ctatactgac aatgtcggtt caatgtatgg agttgacgtt 1447681 tcaaagagtg tcgccggttt aacaactctt acatttggca cttacgataa aaaaggaact 1447741 ttctataata tgaaacatga tgatgattgg atgtataaag gcactgactg gaatctttac 1447801 ttttggacag ctgctagtta taatgctgtt atttttgtat ttgttttggt tattgtgaaa 1447861 caaatgaata aaattcttaa ttaaccagta tgtagattga taatctcaaa aaaattttcc 1447921 tcttctttta acatactcca tacgacctac ttttccatac tatgattttt ttgaaatttg 1447981 tggtgtagtt ataattgtgc gtataatcag acaaagatag agaagcaggt gataacatgt 1448041 tggatccact tgatatttta acgaacattg atgatgtcct tccatattac caggcgattt 1448101 ttagtgccga ggagcagaag gttgtcggat atgaggtgct tggacgaatt ttggcagatt 1448161 cagaaatcca aagtctcggg cccttctttt tagatgcggg gatacccgaa gaatataaat 1448221 tagaggttga taacagaatt atccgccagg ctcttgaccg ctttttagag gcggattctg 1448281 atctgctgat ttttatgaat caggatgcca atctgctgat gctggatcat ggtgaaagct 1448341 ttctggagct tctgaaagaa tatgaagcga agggaatcga actccaccgt tttgtgcttg 1448401 aaattacaga gcacaatttt gaaggggata ttgagcagct ctaccatatg cttgcatact 1448461 atcgtacata cggaattaaa atcgcagttg acaacatcgg aaaagaaagc agcaacttgg 1448521 acagaatcgc gctgctctca ccagatctgt taaaaatcga tttgcaggcg ctgaaagtgt 1448581 cacagccgtc accgtcatat gagcatgtgc tgtacagcat atctttatta gcaagaaaaa 1448641 tcggtgcggc gctgctgtat gaagacattg aggcgaactt ccagcttcag tacgcctgga 1448701 gaaacggagg ccgctatttt cagggctatt acttagtgtc tccatctgaa acgtttctag 1448761 agagagatgt attgaaacaa agacttaaaa ctgaatttca ccaatttatc acacatgaga 1448821 aaaagaaact ggagaccgtc tatgagcact ctgaacagtt ttacaaacga gtgcatcagg 1448881 ctgtgacctc tttgagaaaa aacaatctgt cttctgatga tgactttatt aaaaagctgg 1448941 cggaagagct gacagattgc agcttcagga tttacatgtg tgatgaagaa ggcgatcagc 1449001 tgacgggaaa tgtgtttaag caagatggag aatggattta tcagccggaa tatgcggaaa 1449061 agaactggag ctggcgccct tattttctgg agaacattat gagaatgaga aatctcagaa 1449121 aaggtttttt cagtgatctg tacagtgatt tggaaacagg tgaaatgatc agaacgtttt 1449181 catatccgat ggatgatcag atgtatttat ttatagactt gccttattct tatttatatg 1449241 agcaggacgg actgatttaa cggctgaaag gccgtttttt ttatgaaatg aaaaaaatat 1449301 caaaaaacga ttgacattga tactgagaat cattatcatt taattataga gagaagctac 1449361 tctctgttcc ccaacccctc tatcagatca agatccgaaa aaacttggcg ctacccccgc 1449421 caagtttttt atttgtcaaa gcataggaca atccaatgaa acaataaacc taactagtgg 1449481 taaacgttta acacggggag aaacattgag tgccgaacac ccctgacact gctgcacggg 1449541 tgaggaggaa aattcgttct gaaatgatta tttcagttcc gttgtttacc tctatccagc 1449601 atgactccca ttgattatgg ccacgcggga cttcaccata aaattcaaaa gaaggttttg 1449661 acaaagttgc aaaaaggcat tcttaatgct gccaaagatt cgaaaaaaat tataattatg 1449721 tgcatgacat tcaaaaaaag cctcaaacta aagaaaaata gtttttttca ctttttttct 1449781 ttgcttaaat tcagcagtga aaatgccatc ctgtccgact ttatggtatg atgctcaata 1449841 gaacttgtat tataataaat acttgttgat ttgaagttgc tttttgaaag gagtcttttt 1449901 ttagaatgtc acaattaatg ggtatcatca cacggctgca aagtctgcaa gaaacagcgg 1449961 aagcggctaa cgagccaatg cagcgttatt tcgaagtgaa tggtgagaaa atatgcagtg 1450021 ttaaatattt cgaaaaaaat caaacgtttg aactgacggt tttccaaaag ggtgaaaaac 1450081 ctaacacata tccgtttgat aatatcgaca tggtttccat cgaaatcttt gaacttcttc 1450141 agtaagattc ctgaaatagg gggaacaagc ttccgccttt gcaaaagtaa tcgaaataaa 1450201 cggtaaggaa catacttgtt tcatggttgt aaatccttga aaaggagtgt cgtgatggct 1450261 gattcttttc tgttttataa tctttcagaa gcacagatga cctttcaaga tgtgatggaa 1450321 cggcttaaag cctttgttca aaaggacccc cgttcttctt atgtgttatc gatcggaacc 1450381 gattcacagg tttaccgcga ttacacaaag tttattaccg cattgcattt gcatcgtaca 1450441 ggcaagggag cttggggctg cttgaaaaat catacagtcg acagacccat acatagcctt 1450501 cgggagaaga tttcgttaga aacggcgtac agccaagaaa cggccgctca tattcttgat 1450561 ggacacttaa tggatattac cgatctgctc ctgcccttta ccggtgaggg ggcggatctt 1450621 acctttgaag ttcacttgga tattgggaaa aaagggctta caaaagatct gatccaagaa 1450681 atgactggac gtattacctc catggggatt gaggccaaaa taaagccgga ttcatacact 1450741 gccttcagct atgcaaatcg tttcacaaaa taatttggct gaaaaagcca aggtaaatgt 1450801 cgaattatgc ggttgacgtt tgttatctga ttacttattc tagcggtaga gctgaaagta 1450861 agttgtcttg ctttcagagg tattcagtat aaaacagggg gcctgattgc gaatgagtct 1450921 tatcggtgaa cgatttacag aagaagaaca aaaacttctg ctgaatatcc tgatcaacca 1450981 tgagtatgcc atcgagctat taagcagtga gatcaacgat atagagacag ggaccaaaaa 1451041 cgttgacgga accacctaca aaaaacttgt aacgctatac gaccgatttc gatttgaaaa 1451101 ttaatgggac accctataat tgatactcca caaagagtat cttttttatt gaaaggaaac 1451161 ttttcgacaa atactgataa agtttatatt attgcaatat agggaatgta ttgatgatga 1451221 aaatgaaaag gggtcgaaaa catgataagc ttacaatcag atcaacttct tgaggcaaca 1451281 gtcggacaat ttatgattga ggcggacaaa gtagcgcacg tgcaagtcgg aaataacctt 1451341 gagcatgcat tattagtatt gacaaaaacc ggatacacag ccatcccggt tctggatcct 1451401 tcctaccgtt tacatggctt aatcgggaca aatatgatca tgaacagtat ttttggactt 1451461 gagcgaattg agtttgaaaa gcttgaccaa atcactgttg aggaagtcat gctgaccgac 1451521 attccgcgcc ttcatatcaa tgatccgatt atgaagggat tcggcatggt cattaataac 1451581 ggatttgtct gtgttgaaaa tgacgagcag gtatttgaag ggatttttac gagaagagtc 1451641 gttttaaagg aattgaataa gcatatacgc tcattgaata agtaggctgt acggtcctat 1451701 ttttattata taggcagagt gaaaaaagaa agcgcataca taatttaaac gagaataggg 1451761 cttgaataag aaactaagat tttattagaa tgggagataa gaaaaactta ttgataacaa 1451821 aaaggaggac gacatgcagc ttcaagagct tcatatgctc gtagttttag ctgaggaatt 1451881 aaatatgaga aaggcggcag aacggctttt tgtatctcag ccggctttat ctcagcgctt 1451941 acaaaccatt gaaaaggcgt ggggaacaaa aatcttttta agatctcaaa aaggattaac 1452001 ggtaacgccc gccggtgaga aaatcattca gtttgcgaat gatgtgacat tagagcagga 1452061 aagaataaga gaaaatattg acgagcttga aggtgaaatt cacggcacat tgaagcttgc 1452121 cgtcgcctcc ataatcggtc agcattggct ccctaaagtc ctgaagacgt atgtggaaaa 1452181 gtatccgaat gcaaagatct cgctcataac cgggtggagc agcgaaatgc tgaaaagctt 1452241 gtatgaggat caggttcata tcggcattat aagaggcaac cctgagtgga aggggcgcaa 1452301 agattactta atgacagatc atctgtattt agtggatact gaaatttcct gcatcgaaga 1452361 tattgcccat acagaacgtc cgtttatcca gtttaaaagt gacagcactt attttcagga 1452421 aattcagcac tggtggcatc aaaaatttaa aacgtcgccg aaacagacga tattggttga 1452481 tcagattgaa acgtgcaaac agatggcgct gcacggaatc ggttatgcca ttttgccgtc 1452541 tgttaccctt caaaatgaag ataaagtgaa taaaatgcct cttttagaca tgaaagggca 1452601 tccgatcggt cgggatacat ggttattagg ttatgagcct gcctttgaac tgaaacaagt 1452661 tcaagctttt gtacaagtga taaaggatat gctggatcag gaaaatccat tttaaagaca 1452721 gcgaggtgct gtcttttttt tatttatctg ttgacaatga aaatcattat catttaaagt 1452781 gatacatatg atattgaaaa tcattatcaa ctaatggggt gataacatgg ctaaagcctt 1452841 gattacatat gccagcatgt caggaaatac agaagacatt gccttcataa taaaagatac 1452901 gcttcaggaa tatgagttgg atatcgattg tgtcgagata aatgatatgg atgcgtcttg 1452961 tttaacctcc tatgattatg tactgattgg cacctataca tggggggacg gcgatttgcc 1453021 ctacgaagcg gaggattttt tcgaagaggt caaacagatt cagcttaatg gtttaaaaac 1453081 agcctgcttc gggtctggcg attattctta tccaaagttt tgcgaagcgg tgaatttgtt 1453141 caatgtcatg ctgcaagagg cgggagctgc tgtttaccag gaaacactaa aaattgaatt 1453201 agcgcctgaa acagatgaag atgtggaaag ctgccgagcg tttgcgagag gttttcttgc 1453261 atgggcagat tatatgaaca aggaaaaaat ccatgtttca taaaggggca accgctgtta 1453321 cggcatcggc gttttctgga tattttgtgg cggtacaaag agaaggcatt tttcattact 1453381 ctttggagca gggctggaga aagctttttc gtttgaaaag taagatacac tgtatcagct 1453441 acatagggcc ttacttattt ggcgttggtg aaaagggaac agtcattcgt tcggctgatg 1453501 aagggaaaac ctggacgatg tcgagctttc cgacaaatgc aacagtgtgg gcgattaccg 1453561 gcagaaacaa cgggtttgtc tgcgcccacg gtaagcattg tatttatgta tcggatgatt 1453621 ttggtgtctc atggcgcgta gccaaacctt ttgccgaatt tcataatccc cctgttatcc 1453681 ggtcgttatg ccttcacggg ggcaatctct ttatcggcac gcaaatacac gaatattttg 1453741 gcggcatttg ggcttacgac attaagcgtg acactgtcca agttgtcaaa aaagaaaaaa 1453801 accggatgac ggcatccatg ctcgtgttca atgaaaattg gctggtggcg gcgatgggtt 1453861 ctgtgaaagg aaagcacggt gctgtcactg taaggaatct tttgaatggt gaagaattca 1453921 ccatacaatc cagtatgatc agaaatgaag aatcatttct tgatctttca gaggatgatg 1453981 gcattatata tgtcactaca acacaagatg aaaatggttt ttcgagaatt taccaggttg 1454041 atctcgaagc ccggtcgtta aaatggttcg ataccattaa gggacatgga tggagagtgg 1454101 ccaatcagaa agagaatttc ttttgcgcag gcttgtatga atgtaaattt gtccagccgt 1454161 acgaagtttc agcaatgatt cattagagga ggaacaagga attggcgaag attttgctcg 1454221 tttatgcaac aatgtcaggc aacactgaag ctatggcaga tttgattgaa aaggggcttc 1454281 aggaggcgtt agcagaagta gaccgtttcg aagcaatgga tattgatgat gcccagctgt 1454341 ttaccgatta tgaccatgtc ataatgggaa cctacacgtg gggagacgga gatctgcctg 1454401 atgaattttt agatcttgtt gaagacatgg aggagattga tttttccggc aaaacatgcg 1454461 ctgtattcgg ttccggtgat acagcatatg aatttttctg cggagcggtt gatacgctag 1454521 aggcaaaaat aaaagaacgc ggtggagaca ttgtgctgcc ttcggtaaaa atcgaaaata 1454581 atccagaagg tgaagaagag gaagaattaa taaacttcgg gagacaattc gcaaagaaaa 1454641 gcgggtgcgc tgtctgatca ctcactggga actgctaaaa cggctgttcc tttttttctt 1454701 gtctttgtat ctttcctttg atacagtaat gaggtagaaa atcaggagga ggactataca 1454761 tatgaaaatg atggacgcaa atgaaattat ttcatttatt caaaatagta caaaatctac 1454821 acctgtaaag gtttacgtga aaggtgagct ggaaggaatc aatttcggtg aatctgcgaa 1454881 agcttttatc aatggaaaca ctggtgtcgt tttcggtgaa tggagcgaaa tccaaacagc 1454941 aatcgaagaa aaccaaagca aaatcgaaga ctatgtggtt gaaaatgacc gccgcaattc 1455001 tgcgatccca atgcttgatc ttaaaaacat caaagcgcgt atcgagccgg gtgcgatcat 1455061 ccgcgaccaa gttgaaatcg gtgataacgc agtcatcatg atgggtgctt ctattaatat 1455121 cggttcagtc atcggcgaag gcacaatgat tgatatgaac gttgtgcttg gcggacgagc 1455181 tactgttgga aaaaactgcc atatcggcgc gggttctgta cttgcgggcg ttattgagcc 1455241 gccatccgct aaaccggttg tgattgaaga cgacgtcgta atcggcgcaa atgctgttgt 1455301 gcttgaaggt gtaacagtag gtaaaggagc tgttgttgct gcgggagcga tcgtggtaaa 1455361 cgacgttgag ccatacactg tcgttgcagg cacaccagct aaaaaaatca aagacattga 1455421 tgaaaaaaca aaaggcaaaa ctgaaatcaa gcaggaatta cgccagctgt aaggaaaagt 1455481 ttgataaaaa aggcgtggat aatatatcca cgccttattc gtataggcag gaggaataga 1455541 aatgaagata gaggagctca tcgcaattcg cagagatctg catcgtatac cggagcttgg 1455601 atttcaggag ttcaaaaccc agcagtattt attaaatgtc ttggaacaat atccgcaaga 1455661 cagaattgaa attgagaaat ggcgaacagg gctttttgta aaagtgaacg ggacggcgcc 1455721 ggaaaaaatg ctggcataca gagcggatat cgatgcgctt tctatagaag agcaaactgg 1455781 tcttccattc gcatcagagc atcacggcaa catgcacgcc tgcggtcacg atttgcatat 1455841 gacaattgca ctcggcatta ttgatcattt tgttcaccac ccagtcaaac atgatttgct 1455901 ttttctgttt cagccggcag aggaagggcc tggcggtgcg gaaccaatgc ttgagagcga 1455961 tgtattaaaa aaatggcagc ctgatttcat cactgccctt catattgctc cagagcttcc 1456021 ggtaggcacc attgcgacaa aaagcggcct tctatttgcg aatacatcag agctagtcat 1456081 cgatctggaa ggcaaagggg gacatgcggc atatccgcat ttggctgagg atatggttgt 1456141 agcagcaagt acacttgtca cccagctgca aacgattatc tctagaaaca cagatccgct 1456201 agacagtgct gttattacag ttggtaccat taccggaggc tcggcacaaa atatcattgc 1456261 agaaacggcc cacctggaag gcacgatccg cacgctttct gaagaatcga tgaaacaagt 1456321 aaaggaacgg attgaagatg tagtgaaagg aatcgaaatc ggattccgct gcaaaggaaa 1456381 agtgacatat ccgtctgtat atcaccaagt ttacaatacg agcggattaa cagaagaatt 1456441 tatgtctttt gttgctgaac atcaactggc gacagtaatt gaagcaaaag aagcaatgac 1456501 tggagaggat tttggctata tgctgaaaaa atatcccgga ttcatgttct ggctcggcgc 1456561 tgattctgaa catgggcttc atcatgctaa gctgaatccc gatgaaaatg cgatagaaac 1456621 agcggttcat gtcatgacag gttatttttc tgtttatgcc aattaagtac aaatgaaaga 1456681 ataaaattcc ataaaatgag cactctagta aacggaggtg ttcaaaaatg gctaaaaaaa 1456741 ttggaattga acaatcgtta tcagatgtag aagctgcttt aaaagaaaaa ggatatgacg 1456801 ttgtaatgat gaaaagccct gctgatgctc aaggctgtga ctgctgtgtc gtaacaggtc 1456861 ttgataataa tgtgcaaggg atagccgata cggtaacaca agcacctgtc attacagctt 1456921 ccgggatgac ggctgaagaa atttgtagcg aagttgagag cagaattcag taataaaaaa 1456981 accgaagcaa aaagcttcgg ttcttttatt tattctgttt ctttagggaa agcgcggtcg 1457041 aacgcgttct ttatttcttt tctcaacact cgttcgactc gccactgttc catattttct 1457101 gttttggcaa tgaccctgat tacaatttca gaagtcccca gttcttgaat cccgatgaca 1457161 tttgggcctt cttttatttg tggaagagcc gctgccgttt catcacaaac ctgctgtaaa 1457221 atatgaatca tttcatcaat atttctttca gccggcactt taatgtcaac aagagcctgc 1457281 atggtaccac gagaatgatt gctcacgttt gtgatgtttc tgttggggat gtaatgcagt 1457341 gttccgtcaa agctgcggat ttgagttgtc cttaagccaa cctgctcgac aattccgtca 1457401 aaggtggaaa cggtaatata atctccgaca tccaattgtt tctcaagcaa aataaaaaaa 1457461 cctgtcacga tatcactgac aagcccttgg gcgccaaatc cgacagccag gccgacgatt 1457521 cctgcccccg ctaaaagagc gcttggatca taatgaaaca aatctagaac catgacgaaa 1457581 aatatgaaaa tcaatgtata agcaaatatg ttaagagtca ggcttcggag cgtatgtgca 1457641 cgtccgatag acaagctatt ctgctcctcg aattttgcaa acagatgttt aatgattttc 1457701 atgcctaatg atcgaacgat aaaatagagc aatatcataa tggcgagttt aatgagcaga 1457761 acaccggcat ttgtaatcag tcccgcccaa tcatattgtt taataaagtc catgttgagc 1457821 tccttttcta attgattgct gcacattgag actagttacc ctgtacatga ccatgttaaa 1457881 cgttttattc aaaaatgtcg aagccaaaga catacatgat ttgttaaaaa ttgactcagg 1457941 aaatctgctt ttatataatg gcattgcaat ataactaaaa atggttaatc accctttatt 1458001 ttcatgcgat tttgaccttt aagccaaaca ataaattgga gggatacata tggcagaacg 1458061 tatggtaggt aaacaagctc ctcgttttga aatggaagca gtccttgcaa gcaaagaatt 1458121 cggcaaagta agtcttgagg aaaacatgaa aaacgacaaa tggacagtgc tgttcttcta 1458181 tccaatggac ttcacttttg tttgtccgac agaaattaca gcaatgtctg accgctatga 1458241 cgagttcgaa gatcttgatg cagaagtcat cggggtttca actgatacca tccatactca 1458301 tttagcttgg atcaatacag accgcaaaga aaacggtctt ggccagctga aatacccgct 1458361 tgctgctgat acaaaccatg aggtatcccg ggaatatggc gttttaatcg aagaagaagg 1458421 tgtggctttg cgcggattgt ttattattaa tcctgaaggg gagcttcaat atcaaactgt 1458481 tttccataac aacattgggc gtgatgttga tgaaacgctt cgtgttctcc aggcgctgca 1458541 aactggcgga ctctgtccgg ctaactggaa accaggccaa aaaacacttt aattctttcc 1458601 aagaacgaaa agcggtctag catattcgtt aggcctctct tttaaaatag gagggaaaaa 1458661 gcaatgaaat tacgtcagcc catgccggaa ttgacgggag aaaaagcttg gttaaatggt 1458721 gaagtgacga gagagcaatt gattggggaa aagccgacgc ttattcattt ctggtccatc 1458781 agctgccact tgtgcaaaga agcgatgccg caagtgaatg aatttcgtga taaatatcaa 1458841 gatcagctga atgttgtagc tgtacacatg ccccgttccg aagatgatct tgaccctggt 1458901 aaaattaaag aaacagctgc tgaacacgat atcactcagc cgatttttgt tgacagtgac 1458961 catgctttaa ccgatgcatt tgaaaatgaa tatgtacctg catattatgt gtttgataaa 1459021 acaggacagc tccgtcactt ccaagccggc gggagcggta tgaaaatgct tgaaaaacgt 1459081 gtgaaccgcg ttctggctga aacggaatag gtatctgact aaatagtatt tcctaaaaac 1459141 ctgacctcat caggtttttt atttgtgcaa aaagcaatgg aagaagagta agaagcttat 1459201 ttttccaaat ttgggtatag gaattgatga tttgtttgat tgatacgcta aaaaacacag 1459261 ctaatttttg atgtttttcc tcaattttag ataaatctca tatctcataa ctcgaaaatt 1459321 gtagatatta cactaaattt ctttaaagaa gtaagtaaaa tatatatttt caacattata 1459381 ccaaataaac tagaaagccc cttaatccct tgagaataaa ggactctttt gaaaaataaa 1459441 acattttcag aaaataagga atttttcata gagtaaatat aatagtaaaa tgctaaaata 1459501 atagttgata aaattacttt tgtaatctaa tatcttaatt aaagatgtta attttgatag 1459561 ggggtacatt gaggaatgtt taatgaaaga gaagctttgc gcttgcggtt agaacaatta 1459621 aatgaagctg aagtgaaagt cattcgtgaa tatcaaattg aacgtgataa aatatacgca 1459681 aaattaagag agctggacag aaatggaagc ccttccgaaa tcaaaaagga tttccgttct 1459741 gaaaaaaaac ctgactctct gccggttctc gctgagcttg cggctcagga aatcagaagc 1459801 tatcagccgc aatcacagca gcagtctgtt cagcctcagc ttcaatctat ttcctctctt 1459861 cctgccggta taccagacgg aacaacacga agaagaagag gaacggcaag accgggatca 1459921 aaagcagcta agctgcgtga agctgctatt aaaacattaa aacgccacaa cgcggcgatt 1459981 aagagctcgg agcttcaaaa agagattgaa aaagaaagcg gtcttgaaat ccctaatatg 1460041 acaacgttta tgcaaagctt aattaaaatg tacccggaag tgaaaaagcc atatcgcggg 1460101 cagtacattt tagagggtga aatcgaatct gcagaatcag caaacgaata aatataaaga 1460161 aaaactgctt ggcatcgctc aagcagtttt tttattgagg ttttttctgt gaaggtttgt 1460221 tttctttttc aagattaagc ttatacaccc acttttgata aggcttttct tcagcggctc 1460281 tgtttttcag ctcttcgatt gtatggctct tggcctggtc tgatgattgg gcgtgggcaa 1460341 gctgtttttg aagcacatgt atctgtttgg tgacatcttc aaggatagtc tctacatgat 1460401 ttggctgcgc gtaggccgct ggagcttctt cttccgtttt ttctttttgt ttcgtgccgc 1460461 catcaatatc ggcaaaatga gaagcaatcc aggcatcgct ttcatcaagt tgccgtttat 1460521 acgatataat agtttcgtga aataattttt ctttcgtttt ttctatgtct agcagtcttt 1460581 ctttcgtttc tatgattcga tctttcatat gatcaacttc tattttaata tgttttagct 1460641 gatattcttt ttctaccatt tgctctttta gacgcccgtt ttcggctttt atcaattcgg 1460701 cttgctgttt tgcctgaagc agtgcatttt gttcctgctc aattgaggct tgaagttcgc 1460761 tgatccgttt atgaagattt ttattttctt cttcgatttt gactttcgca atatgaagtt 1460821 tatgtttttc ttcgatttcg gctctgcgtt tataggtttc agcagataga agctcctgca 1460881 aaacaacgat tttatcaagc agttcagctc ttatttggtg cagggtttgg ctggtgtggg 1460941 aggcatgttt ttcttttgtt gacatatgtg ttaattcggc agacagctgc tggagttttt 1461001 ctttcatatc ggtattttct ttgagcagtt tgttattttt ctgatgaaag tagcttgctt 1461061 caagttcaga aatcagctta tggcaccttg aaagctcgga ttttaaataa aggttctcct 1461121 gagacacgtc gtggaaaaaa ggacctgatc ttttcattcg aaccatctcc ctcatgatgt 1461181 taacactaca atatgcaaat actgaacagc tattcctctt taataaacag acaagcagta 1461241 gcgttgagcc tttgcttttg ctatgctttt aacgaaacta gaggtgagat gatatgaagc 1461301 atgtaaacgt actgctggca gggggagcct cacgtcgctt tggagaaccg aaggcgtttg 1461361 tcaaatggaa gggcaggatg ctttacgaat gcgctaaaga ggcacttgga gaacaaacgg 1461421 ttatcatcag ccgtcccgaa tttattgata gatttcaaga aaacggtgaa aatgaagtgt 1461481 atcaagatgc tgagccattt caaggcatgg ggccattggc tggtatatat accgctttta 1461541 aaaagacaga cggtgatctt tatactgttc tttcctgtga cacaccgctg atacaaagaa 1461601 ggacgatgct ggagctcaaa cgtctgatga ttgccggtgc ggacgcggta gtcccaattt 1461661 cagacggaca agtgcagcca ttgattgcga tttaccacaa acgtatcatg ccagttctat 1461721 acgatcagct ttctgagaag aggttgagaa tatcagattt attaggcaga atttcggttt 1461781 gttacgtaca ggctgaaaat atcggagcaa acccggcaga gtttatcaac attaatacac 1461841 gtgatgattt tagctgtttg gaagaaaaat cgaactccct caagcgggac tgacggggca 1461901 ataacatgat aagatgacat aaaagataag gagaacaggt ttgatggagg aacgttattc 1461961 acggcaaatc agatttaagc aaattgggga agagggccag aaaagactgg cagacagcca 1462021 tgtgctgatt gtcggagcgg gagcgctcgg cactgcagga gctgaagggc tttcgagagc 1462081 gggagtcggt acgattacca ttattgaccg tgactatgtg gagtggagca atcttcaaag 1462141 gcagcagctt tatacagaaa gcgatgccaa actccgcatg ccgaaagcca tggctgccaa 1462201 agagcatcta tcagcgatta acagcgagat acatattgag gcgtatgtta ccgaaggaac 1462261 agccgaaacg cttgagccgc tgattgaaaa agcagatgtc gtgatcgacg cgacagataa 1462321 ttttgaaacc cgcatgctga taaacgatct tgcccagaaa acaaagacac cttgggtcta 1462381 tggcgcctgt gtaagcagcc agggaatgtt catgactgtc attcccggag aaaccccttg 1462441 tctgtcttgt ttgtttgagc aaattcctgt cggcggggcg acgtgtgata ctgccggcat 1462501 tattccgcct gctgtgcata tcgtttcagc atatcagcag gctgaggcat taaagctgtt 1462561 aaccggccaa aaagaagcaa tacagcgggg gtttgtgaca tttgatgtct ggaacaattc 1462621 gcatatgaag attaacgtta atcatgtacg ccgtgaggaa tgcccatctt gcggagctaa 1462681 tgcggtatat ccttatcttc aggattggaa cacaccaaaa gctgctgtac tatgcggccg 1462741 tgatacagtg caggtaaggt cagaatcatt aaaaagaatc ccgaaacagg agctcattaa 1462801 gcggctgaaa acaatcggca aggtcgaggc taatgcgttt ttgctgcata ttttttacga 1462861 ggatttcaga attgtcattt tcaatgacgg acgggcactg gtgcatggaa caaatgatgt 1462921 gaaagaagcc aactccgtgt tggcaagagt gattggactg taacaacagg aggggtcaga 1462981 atgctggaga aaagaacacc gataccggta gacgaggcag ttcggcgtgt ctgccatttt 1463041 caaaaacaag gtgaaacaga atgggtggcg cttgaagaca gccttcatcg gtttttagcc 1463101 gaagatataa ctgcggatca ccacgtacct gcgtttgacc gttcgccata cgatggtttt 1463161 gctgtcagag cgtgcgatac ggcagaagct tcacgtgaaa acccagttcg gtttgaagtt 1463221 attgaccata ttggagcggg agcagtatct gaaaaagaac ttggcccgtt tcaggccgtg 1463281 cggattatga ctggcgcgca aatccctgaa ggggcagatg cagtcgtcat gattgaactg 1463341 actcaagcct ttgaggagaa tgggaagtca tttatgtctt taaaacgccg ctttcagacg 1463401 ggggataata tttcaaaaac aggtgaggac gctcaaaaag ggagtgtttt actgacaaag 1463461 ggcacccggg tgacaccagg agtgacggct cttttggcaa cattcggata cgcatctgtg 1463521 cctgtcgtga gaaagcctgt agtcgggatt atcgcaaccg gtaccgaatt gctgaatgtc 1463581 agtgatccgc tggaaccggg aaaaatccgc aacagcaatg cgagtatggt atatgcgcaa 1463641 gcgatagaag caggcgcaac accgctttat ttagggaaaa tctctgatga actggataaa 1463701 agctttgctg cagttaaaga agcgatgaaa aaggtggact tcctgatcac aactggcggt 1463761 gtgtcagtcg gtgactttga ctttttgcct gcgatctatg aaaaactcgg agcggacgtg 1463821 ctgtttaata aagttgccat gcgcccgggc agcgtgacaa cggtggcgca tgcaaacgat 1463881 atgctgctgt ttggcctttc aggtaatccg tcggcatgct atgtcggttt tgaactgttt 1463941 gtcaaaccga taatccagac atggctgctc aatgaaacac cgcattcaat ttgtgcggaa 1464001 gctgttttga ccaaggattt tccgaagccg aacccattta cccgatttgt tcgtgcgctc 1464061 gtgcaccatc aggaagggaa gctgttggcg acacccgttg gcttagataa gtcgagctct 1464121 gtcacatcac ttgcagatgc caatgcattt attatcctgc cgggcggtac gcgaggctac 1464181 gaatctggca gaacggttca agtgctgctc atcagagaag agaatggaag tgaatggcct 1464241 tggtccgtcc tttcccgatc gtccaagttg taggatttca aaacagcggg aaaacaacgt 1464301 ttattgagcg cattcttgaa aaagcctctg aacagggagt ccatttgggc tgcctgaagc 1464361 accatggtca cggcggtgaa ccgcaaacgc tcacggaagg aaaagacacg gaccgttaca 1464421 aggcggcagg tgctgatgta acagcggtag aaggtgctgg tgtgttacag ctgactgccc 1464481 gccgcaattg ggatttggca cggctgattg agttatacca atttctcgaa acagactgtc 1464541 ttctgattga aggctttaaa aaagcccctt atcctaaagt ggttatccta agtgaaaagg 1464601 aagatctgga agcgctgcaa gcagtaaata taatcgccat catctataga aaaaaagagc 1464661 atatgacaga gcatcaggga ttacccgttt ttcatgcgga tgatccggtt gccgtggatt 1464721 ttgtgctttc acagctgaag ggggaatctg cataatggaa cggtttgaga ttacgaaaac 1464781 acccattaat actgaaaaca tcatcaaaaa agtggagaaa cgggaagcgg gagccattac 1464841 aacatttatt ggtacggttc gggaatggac aaacggaaaa agaacggttc ggcttgaata 1464901 tgaggcatat gaaccgatgg ccgtgcaaat gcttgctcaa atcggcgctg aaatcgaaga 1464961 aaaatgggaa ggtgcctcag ctgcgatcac gcaccgtata ggtgtgctcg atatcggtga 1465021 agcagcggta gtgattgctg tatcttctcc ccatcgaaaa gccgcatatg aagccaatga 1465081 gtatgcgatt gaacgcatta aacagattgt gccgatttgg aaaaaagaaa tttgggaaga 1465141 cggtgagcaa tggatcggcg accagctaga aacgacagct tatccgaacg gaaaaccaga 1465201 cctaagcgag ggagagcagc atgattaaaa ttcttttatt tgcagggctt gctgaacagg 1465261 ccggtacaca agcaatagaa atagatatgg aacaagcaac cacagatgaa ataaaagcga 1465321 gtctaaaaga acaatacggt cttgaatcta ttgatacggc tatgattgcc gttaacgaaa 1465381 gctatgtaaa agaaaatacc tctgtatctt cgggtgacac ggtagccatc ataccgccgg 1465441 tcagcggggg atgaaaaccg gacggcattt cagccgtccg gtttttctgt atttcattgg 1465501 catatcccca agtatcctca gcatacaatg attttctgta agcgtttatt ctacatatgt 1465561 tactccctat aaagtaagag actcactcca taattagact gaaattttga aaaataatag 1465621 aaatttattt cgggtatcga tatagtgaag atgataaatg ttggaaaggt gctggatatg 1465681 gagacattta aaagattaaa aatgtattat tggccgtaca gaaaagtgtt tatgtggtcg 1465741 cttctagcca tgcttttgat gactgcaatt actgtcgttt atccgattat cctgcaaatt 1465801 acgattgatg agatcgtact gggacggcag tatcagcttg cggcgtgggt cagcttagga 1465861 tttattgcgg tgatggtttt gaaaggaatg gctacctttt ttcatcagta tttaggtgat 1465921 atgttcggga tcaaatccgt ttatcggctg agaaatggtc tgtatgaaaa actgcagcgg 1465981 ctttcttttt cttactatga taacgcgaaa acaggagatt tgatgtccag gctgactgct 1466041 gatgttgaag ggcttcgttt tttcttatca tacggtctcg ctgagctcat tcgcttcggc 1466101 ctgctggtag ccatcagcct gtcggttatg ttttactatt ctgttcctct cacgcttgtg 1466161 acaatagctg ttctgccatt tctcgcggtt gcggtatacc ggtttgacaa aagagtccat 1466221 cccgccttca gaggcatccg caaatcgttt gcgaaactca atacaaaagt tcaggaaaat 1466281 atcagcggca ttaatacggt taaatctctt tccagggaag attttcagat cagcactttc 1466341 aataaagcca atgcagaata cagggcgcag tatttacaaa catcatccat ttggtctgcg 1466401 tatttccctt taatggagtt cattggtaac acttgtattg tagctcttct ctcatacggc 1466461 ggttacttgg ttatgcaaaa tcagctcaat cccggcgagc ttgttgcttt cttcagcctt 1466521 gtcaattata tgatgtggcc cattatgaac ttaggttttg tcatcaatat gttctctcaa 1466581 gcaaaagcgt caggggaacg cctgctcgac attctggaaa aagaagaaga cattacagat 1466641 catcctcatg ctttgcataa acaaaaatta accggagatg tccatttcaa aaatgtttct 1466701 cttgcatacg gaaaagaaca aacaaacgcg ctgtgcaatg taagctttga ggcaaacagc 1466761 gggaaggtaa tcggactgtt gggcccgaca ggttcaggca aaagctcagt gacacagctt 1466821 ctcaccagat tttacagtcc tgttggcgga atgattacca ttgatcacaa acccatcaca 1466881 gattattcgt taaaaaccct tcgctccaat atcggggtcg tacttcaaga atccttcctg 1466941 ttttcatcta cgattagatc aaatatttcg tatgggcggc cggatgcctc aatggaagac 1467001 gtcatcgaag cggcaaaaag ggcgcaggct cataacttta ttatggagct tcctgatggg 1467061 tatgacacca tgctgggaga gaggggaatg gggctttccg gcgggcagaa acagcgtatt 1467121 gccattgcga gagccatctg cttgaacccg agcattttaa tattggatga tgccacaagc 1467181 gcagtagata tgcaaacgga gcacagcata cagcttgcct taaaagaagt catgaaaaac 1467241 cgcacaacct ttatcgtcgc tcaccgcatt tcttcactga aacacgctga tgaaattctc 1467301 gtttttaata aaggacgcat tcgtgaaagg ggaacacatc atgagcttct tgaaaaaggc 1467361 ggctactata aaaagattta cgatttgcaa taccgtgatg tcaaaatgat taatgagccg 1467421 catgaggtcg gatagggagg ggccaaatga aacaagcgaa aaaacagggg gttttagagc 1467481 gtttctatta ctcttcagat gaaatcattg aaaagccgtt taactgggct caaatgtggc 1467541 ggctgctgag ctatgtcaaa ccatatcgaa aaacaatttt gccgctttct tttctcactg 1467601 tattgattgg cactgctgtg aagcttgtga tccccatttt gatcggcgtt tatgttcttg 1467661 atcaagcgat tacagggaga aactcggagc tgctgattca gctcattttt attattagcg 1467721 gtttatatgt cctcaattac gccgccaatg tgttaagaat caggtggatg aatcagcttg 1467781 gccagcatgt catttacgat ttgcgacagc atttatttac ccatgtgcag cgcttatccc 1467841 atcgattttt tgatcagcgg tcggcgggat cgatcttagt caggatcatg aatgatatta 1467901 actctcttca ggagctcttt acaagcggag tcatcaattt gttgaccgac ttgctgcttc 1467961 tggccggcgt gattattatt ttgtttacgc tgagccctga gctgactata gccatcatgg 1468021 tgacattgcc gattatgttt tttatttcaa caagtctcag aaaaaaaata cgccgatcct 1468081 ggcaaacggt acggctgaag caatcgaagc tcaactctca tctaaacgaa agcattcagg 1468141 gcatccgggt cacgcaggca tttacgcagg aagaagaaaa catggcgtat tttgacggtg 1468201 tcaatcagga gaactacgaa tcatggcggg aagcaactag aaaaaatgcc atgttccgtc 1468261 cgcttgtaga aatgacgaat gcgattggga cggctgtctt gatttggtat ggagccacac 1468321 tcatcatgaa tgaaaccatt acgattggcg tcttcgtttc ttttgctttc tatctgggaa 1468381 tgttttggga acctatttcg agactgggtc aggtctataa tcagctgtta atggggatgg 1468441 catcatcaga acggattttt gagtttctgg acgaacagcc aaatgtcaag gagaagccga 1468501 atgccattca taatgaaaag ataaatgggg agatcagttt tgaagaggtt gaattttcgt 1468561 atgatgaaaa acgaaaagcc cttcacgccg tttctttctc tattcctgcg ggatcgacgc 1468621 ttgcgcttgt cgggcataca gggagcggga agacgacgat tgccaattta atcagccgtt 1468681 tttatgatgc ggccggaggc accattaaaa tagacggtat accgattaag gatctttccc 1468741 ttgccagtct gcgctctcaa atcagcattg tcctgcaaga tacatttatt ttctccggga 1468801 ccatcatgga aaatattcgt tttggaaggc caaatgcttc ggatgaagag gtgatgaaag 1468861 cgtcccaagc ggtcggagcg gatgagttta tttccgattt agcggaagga tacgcaacag 1468921 aggtagagga aaggggcagc gtactgtctg ccggtcagcg ccagctcatt tcatttgcaa 1468981 gagcattgct cgccgatccg gctattatca tccttgacga agcaacggca agcattgata 1469041 cagagacaga agtaaaaatt cagcaagcgt taaaaacgct tctgaaaggg cgtacagcag 1469101 tgatgatcgc tcacagattg tctacgatcc gcgacgccga ccgcatcatt gttcttgatc 1469161 acggcaggaa aatagaagaa gggaaccatg atcagctgct cgctaaagga ggcatttatg 1469221 ccgggcttgt gaaagcgcaa tacagcacag cgatagaata atatgaaaag ccttcaatat 1469281 tgaaggtttt tggaaattta ttagaaaaac atgaaacttt ttgatatcct tcccgtacta 1469341 tttgttagat attctcaagg aggttttgaa atggaaacga atgtagaaaa aaacagcgga 1469401 acggcgactg aaaagccttc acttttcgga gtaatcacaa gtccgtccgt tcaatttgaa 1469461 agaataagag aaaggccggc tgtatgggga ccgcttttga ttgttgcagc aattatcatc 1469521 gtcggtgccg tgctgcaatc actcggtacg gattatagtg agcttttgaa aagccaggat 1469581 acgcaagggc tatctgctga acaaatggaa actgtcgcaa caataaccaa atttggcgga 1469641 atggcaggcg ctattatcgg cggtatcgca gcattattta ttgcccctct tatttattgg 1469701 ctctgtgtaa aagtatcagg cggtgttacg acatataaaa aaatgctttc tctcagtctg 1469761 tttgtctctt tgattagcag tctcggatta ttggttaatg gaatcgttgc ttttacgact 1469821 gacgtgaatc ctctttacag cacgacgtca ctcgcaggga ttatcccatc tgacggggct 1469881 ctcgccagtg tgttaaatac ctttgaaatt ttcagcatct ggagctttgt attattagca 1469941 atcggacttc acaaaacggg aggcatctca aaaaaagccg ggtggatttc agcaatcatt 1470001 ctattcggaa ttttagttgt attttcgctt ttttcaggtt taatcaattc tgtggcgggt 1470061 gcataagctc atgaaaaaag tctggatcgg aattggaatc gcagttatag tcgctctttt 1470121 tgttggaatc aatatatacc ggtctgccgc tccgacaagc ggcagcgccg gcaaggaggt 1470181 acagacgggg agcgttgaag aaaatgaaat ctcatcaacg gttatggttc ctggcacgct 1470241 aaaattttca aatgaacagt atgtctttta tgaagcggat aaagggacat tagaagacat 1470301 taaagtaaag gaaggcgata aagttaaaaa gggcacggct ttagtcacct atacaaatga 1470361 gcagctgagc ctggaaaaag aacagaacca gttaacgtct gaatccaacc ggcttcaaat 1470421 tgaccaaatt caagaaaagt taaaagcctt ggacagcaaa gaaagagaac tggaaaaaca 1470481 ggtaggaaag aaagaagcag aaaaacaaat cgaatctgaa cggacagagc ttcaaatgca 1470541 gaaaaaaaca gcggagatcg aattaaaaca aaccgagctt cagcggcagt cacttgccaa 1470601 ccgggtgtca gatttagaag tgaaaagcga aattgaaggc accgttattt ctgtcaacca 1470661 agaagcggca tccaaaaagt cagatattca agagcctgtc atacatatcg gcaacccaaa 1470721 agaccttgtc gtctcaggga aattgtctga atacgataca ttgaaagtca aaaaaggcca 1470781 gaaggtcaca ctcacttcag atgtaataca gggtaaaaca tggaaaggca cggtttccgc 1470841 agtcgggctt gttccggatc agcaggagag cgctgcggca caaggaacag aacaggcggt 1470901 ccaatacccg cttcaagtga aaataaaagg aaatcttcca gaaggaaagc caggctttaa 1470961 atttatcatg aatattgaaa cagataaacg gaaagcaaat acgcttcctt caaaggcagt 1471021 caaaaaagaa gatgaccaat attatgtgta tacagtaaaa gacggaaaag caaagcgagt 1471081 tgatgtcaaa atcggcgaag tgacagatga cctgacagaa attaaagagg ggcttaccca 1471141 agatgatcaa gtcattttga atccatctga tcaggtgact gacggaatgg aagtgaaatc 1471201 ctaaatgatt cagctttcta atgtgcgaaa aagctaccag atcggaaagg aaacgtttga 1471261 tgttctccat tctattgatt tggacattca tcaaggtgaa tatgtctcga ttatggggcc 1471321 gtcaggatca ggaaaatcga cgatcatgaa tattatcggc tgtcttgatc ggccgacttc 1471381 cggtacatat caattggacg gcgaagacat ttcttcatat aaagataaag aactggcggc 1471441 agtccgtaac cggtccatcg gttttgtatt tcagcaattt cagcttcttc cgcggctgaa 1471501 cgcaaaaaaa aatgtcgagc tgccgatgat ttattccggg ataggcaaaa aggaacgtca 1471561 agagcgggct gagagagcat tggaaaaggt cgggttagcc gatcgaatgc tccacatgcc 1471621 caacgagctg tcgggcgggc agaagcagcg ggtggcgatt gcgagggcga tcgtgaatga 1471681 gccgaaattg attttagctg atgaaccgac cggcgcgctg gatacgaaaa caagcgaggc 1471741 gattatggat cagtttacag cattaaatgc cgagggaacg acaatcgttc tggttactca 1471801 cgagcctgaa gtagcagatt gcacgaatcg gatcgtcatg gtgcgtgacg gaaacattgt 1471861 tcctgccagc tccggacaaa ggagtgtggg agaatgagcc tgttggaaaa catcagaatg 1471921 gctctaagct ctgtccttgc ccataaaatg cgttcgatct taacgatgct cggcattatc 1471981 attggtgtag gctctgtcat tgttgtcgtt gcggtaggac agggcggcga gcaaatgctg 1472041 aagcagtcga tcagcggccc gggaaatact gtggagctgt actatatgcc tagcgacgag 1472101 gagcttgcaa gcaacccgaa tgccgcagct gaatctacgt ttacagaaaa cgatattaaa 1472161 ggtttaaaag gaatagaagg cattaaacaa gtcgttgctt cgacttctga aagtatgaaa 1472221 gcgcgttatc acgaagaaga aaccgatgct acggttaacg gaataaatga tggatacatg 1472281 aatgtcaatt ctttgaaaat cgaaagcggc agaaccttta ccgacaatga ctttctcgcg 1472341 gggaatagag tcggaatcat ctctcaaaaa atggctaaag agctgtttga taaaacctcc 1472401 cctctaggtg aagttgtctg gattaacgga cagcccgttg aaattatcgg cgtgctgaaa 1472461 aaagtaacag gcttgctttc tttcgattta agtgaaatgt atgtgccatt taatatgatg 1472521 aaatcctctt ttggcacaag tgatttcagt aacgtatcat tgcaggtcga atcagcagac 1472581 gacataaaat cggctggaaa agaagcggca cagctggtaa atgacaatca tggcacagag 1472641 gattcgtatc aagtgatgaa catggaagag attgcggccg gaattggcaa agtaactgca 1472701 attatgacga cgattatcgg ctcaattgca ggtatttccc ttttggtcgg cggaatcggt 1472761 gtcatgaata ttatgctcgt atcagtcaca gaacggacgc gggaaatcgg aatcagaaaa 1472821 tcacttggtg cgacgagggg acagattctg actcagtttt taattgaatc agtcgtattg 1472881 acgctgattg gcggtctggt cgggattggt attggatacg gaggggccgc gcttgtttca 1472941 gccattgcgg gctggccgtc actcatatcc tggcaggttg tatgcggggg cgtgctgttc 1473001 agtatgctca ttggtgttat tttcggcatg cttcctgcaa ataaagccgc aaagcttgat 1473061 cccattgaag cgctgcgtta tgagtagcct catgcaacat gcatgaggtt tttttatgtt 1473121 tagtgatttc tactatgaat ataaaagact tttttcatta aaataagaag aaaatgtcgt 1473181 acaattgtcc ttatttttgt cgaatttaca gtttacaaac cctatagaca tacgttaata 1473241 tggagaaacg tgaaagattt tgatagttat tgaatgaatt tgaatgattt tagttgccta 1473301 aaccgaaaat agcgtttaca atgaaattgt attcaaaatg aatacgtttt cattaggagg 1473361 tgaagcatgc taactcctga acggcatcaa ttgattattg atcaaataga aaagcatgat 1473421 gtggtaaaga ttcaagagct tataaatctg actaatgctt ctgaatcaac aatcagaaga 1473481 gatttatcga cccttgaaga acgcggtttt ttaaagcgcg ttcatggtgg agcggccaag 1473541 ctttccgata tcagacttga acccgatatg cttgaaaaat catccaaaaa ccttcacgat 1473601 aaactgaaga ttgctgaaaa agctgcttct cttttagaag aaggggattg catttacctt 1473661 gatgcaggca cgacgacatt gcacatgatt gattttatgg ataaaaccaa agatattgtc 1473721 gttgtcacaa acggggtaat gcatatcgat gcattaataa ggaaagaaat ttctttttat 1473781 ctgcttggag gatacgtaaa gcacagaacg ggcgcgatta ttggaggcgc ttcattggtt 1473841 gccatggacc agtacagatt tgacaagagt tttctgggga caaacggtgt ccatacagag 1473901 gctggattta caacgccgga ccctgatgag gcccttttaa aacagaaagc gatcaaacag 1473961 gcaaaacacg cttacgtctt agcagaccct tcgaagttcg gagaaatttc attttcggca 1474021 ttcgccggaa taggcgacgc aacaatcatt acgactgacg ctgaagagct tacattcgat 1474081 aattaccaag aaaaaactgt cgtaaaggta gtgaaaccat gatttacact gtaacactta 1474141 atccatctgt cgattatata gttcacgttg aagattttac tgtaggaggc ctgaaccgtt 1474201 cttcgtatga taccaagtat ccagggggca aaggcatcaa cgtatcgaga ctgctgaaaa 1474261 gacaccatgt ggcgtctaaa gcgctcggat tcgtcggcgg atttaccgga gaatatatca 1474321 aaacattttt acgggaagaa aacctggaaa cagctttttc tgaagtaaaa ggggataccc 1474381 gtatcaatgt aaagctgaaa acgggtgatg aaactgaaat taacgggcag ggaccgacaa 1474441 tttcggatga agatttcaaa gcctttttag aacagttcca atctttgcaa gagggagata 1474501 tcgttgttct tgcaggaagc attccatctt cactccctca cgatacttat gaaaaaatcg 1474561 cagaggcctg caaacagcag aacgcacgag ttgttctgga tatctcaggc gaggctcttt 1474621 tgaaagcaac agaaatgaaa ccatttttga tgaagccaaa tcatcatgag cttggagaaa 1474681 tgttcggcac ggccattaca tctgttgagg aagccgttcc ttatgggaaa aagcttgtag 1474741 aacaaggcgc tgaacatgta atcgtatcaa tggccggaga cggagcgctt ctgtttacga 1474801 acgaagctgt ttattttgct aacgtgccaa aggggaaatt ggtaaactca gtcggagcag 1474861 gggattccgt tgttgcaggt ttccttgccg gaatttccaa acagctgccg cttgaagaag 1474921 cattccgctt aggagttact tcaggcagtg ctaccgcgtt ctctgaagaa cttggaacag 1474981 aagaatttgt ccagcagctt cttcctgaag ttaaggtcac acgtctatag aggaggaaac 1475041 acaagtgaaa ataactgagc ttttaacgaa gcatacgata aagcttaata ttgagagcaa 1475101 agaaaaagaa aatgttattg acgaaatggt cactgttctt gataaggctg gaaagttaaa 1475161 tgaccgacaa gcctataaag aagccatttt aaatcgcgaa agccaaagct ccacgggtat 1475221 cggtgaagga atcgctatcc cccatgcgaa aacggcaagc gttatcaacc cggcgatcgc 1475281 gttcggacgt tcaaaagacg gcgtcgatta tgaatcatta gacggccagc cggctcactt 1475341 agtgttcatg atcgcggcga ctgaaggcgc aaacaacact caccttgaag cattgtcaag 1475401 actttcaacg ctgttaatgc gtgaagaaat ccgtaagcag ctccttgaag ctgagtctga 1475461 agatgccatc atcgacatta ttaatcagca cgataaagat gatgacgaag aggaagagga 1475521 agaagaagcg gcaccagcac ctgccggaaa agggaaaatt ttagcggtta ctgcatgccc 1475581 gacaggtatt gcccatacat tcatggctgc ggatgccctt aaagaaaaag cgaaagagct 1475641 tggtgtggaa attaaggtcg aaacaaatgg gtcaagcggc attaagcaca agctcactgc 1475701 ccaagaaatc gaagatgcac ctgcaatcat tgtcgcagcg gacaagcagg ttgaaatgga 1475761 acgttttaaa ggcaagcgcg tacttcaagt tcctgtaacg gcgggtatca gacgtccgca 1475821 agagcttatc gaaaaagcga tgaatcaaga tgcgccgatt tatcaaggca gcggcggcgg 1475881 ttcagcagct tcaaatgatg atgaagaagc gaaaggcaag tctggaagcg gtatcggaaa 1475941 cacgttttat aagcacctga tgagcggtgt cagcaacatg cttccgttcg tagtcggcgg 1476001 cggtattctc gttgcgattt cattcttctg gggaattcac tctgctgatc cgaatgatcc 1476061 tagctacaac acgtttgcag cagcattaaa ctttatcggc ggcgacaatg cattaaaact 1476121 cattgttgca gttctggccg gtttcattgc gatgagtatt gcagatcgtc ctggttttgc 1476181 gcctggtatg gtcggcggat ttatggcaac tcaagcgaat gctggattct taggcggctt 1476241 aattgccgga ttccttgccg gttatgtcgt gattttactg aaaaaagtat ttacgtttat 1476301 ccctcagtca cttgatggat taaaacctgt tttgatttac ccgctgttcg gtatttttat 1476361 cactggcgta ttaatgcaat ttgtcgtcaa tacacctgta gcggcattta tgaatttctt 1476421 aacaaactgg cttgaaagcc ttggtactgg aaaccttgtg ttaatgggta ttatcttggg 1476481 cggcatgatg gcgatcgata tgggcggtcc gcttaataaa gcagccttta cgttcggtat 1476541 cgccatgatc gatgcaggca actatgcgcc tcatgcagca atcatggccg gcggtatggt 1476601 tcctccgctt ggtatcgcac ttgcaacaac cattttcaga aacaaattca ctcagcgtga 1476661 ccgtgaagct ggtattacat gctatttcat gggagctgct ttcgtaacag agggagcgat 1476721 cccatttgct gcggctgatc cgcttcgcgt cataccagct gctgtagtcg gtgcagctgt 1476781 tgccggcgga ttaactgaat tcttccgagt aacgcttccg gcgcctcatg gaggagtatt 1476841 cgtagctttc attacaaacc atccgatgct ttacctttta agtatcgtga tcggtgctgt 1476901 cgtgatggca attatcctcg gtatcgtcaa aaaacctgtt acagaaaaat aagaaaaaaa 1476961 gcgtccttgg ttcgaaagga cgctttttct tatccggccg gcagggagcg cggttaagtt 1477021 atgtatttta ttctttttta tgataaagta aaagaagaga aacaactgac atagcaattg 1477081 tctaggagga aacactttga ccgaggaaaa aaatacgaat actgagaaaa cggcgaagaa 1477141 aaaaaccaat acgtacctgg aatggggtaa agcgattgtc atcgctgttc tgctggctct 1477201 cctgatccgt cactttttgt ttgaaccgta tttagttgaa ggttcatcta tgtatcccac 1477261 attacatgac ggagaaaggc tgtttgtgaa taaaacagtc aactatatcg gcgagctgaa 1477321 gcgcggagat atcgttatta tcaacggtga aacttctaaa atccattatg taaaaagatt 1477381 gatcggaaag cctggagaaa ccgttcaaat gaaggatgac acgctttata taaacggtaa 1477441 aaaagtagcc gagccttact tgtctaaaaa caagaaggaa gcagaaaaac ttggtgtcag 1477501 tctgacagga gactttggac cggttaaggt tccgaaaggc aaatactttg tcatgggaga 1477561 taaccggctg aattctatgg acagccgaaa cgggctggga ctgatcgcgg aagatcgaat 1477621 tgtcggcaca tcgaagtttg tctttttccc gtttaacgaa atgcgtcaaa caaaataaaa 1477681 acgccttgct ggcctaggac agcaggcgtt tttattttga aaaagaagcg accaatgcaa 1477741 tgcataaaac cgtgatgaac actgaaccga taatagccag cacactgaag aaaaggtgaa 1477801 cctgtttgtt ctcttttccg cgcttttcta atagccgttt agaaaaaatg tgcgaaaata 1477861 tgtaaataag ggctatgcct atatataagc cgatatcttt ggcggtaaag cctgttacgg 1477921 caaggtaaaa gcccgtaaaa aagatcagta agcaatattc agtaagtgtt aaaagcctca 1477981 acgtgttcct ccatgagagt gtgtaatttt ccaggcggat gcattctctc tctttaattg 1478041 taacacagct ggctggtttg ggtgtataag tgttttctct ctgttttatc agggaatcat 1478101 ttctcttgcc ctgcattcat ggtatacttt tattgatgat agacatgatg gaggataata 1478161 aatgattgct gtaaataatg taagcttgcg gtttgcggat cgcaagttat ttgaagatgt 1478221 taatattaaa tttaccccag gcaactgcta tgggttaatt ggtgcaaacg gtgccggtaa 1478281 atcaacgttt ctaaaggtgc tgtcaggcga aatcgagcct cagacaggcg acgtgcatat 1478341 gagtcctggc gagcgtcttg ccgtcttgaa gcagaaccat tttgagtacg aagagtatga 1478401 agtgctgaaa gtggtcatta tgggccacaa acgcctgtat gaagtcatgc aggagaaaga 1478461 cgctatttac atgaagcctg atttctcaga tgaggatggg attcgtgctg ctgagctaga 1478521 aggtgaattc gcggaactga acggttggga agcggaaagt gaagctgcga tcctgttaaa 1478581 aggccttggt atctcagaag atctgcacac aaaaaagatg gcagacctcg gcggttcgga 1478641 gaaggtaaaa gttctcttgg cacaggcatt attcggcaag ccggatgttc tgctgctcga 1478701 tgagccgacg aaccacctgg accttcaggc aattcagtgg cttgaagagt ttctgattaa 1478761 ctttgaaaac acagttattg tcgtatccca tgaccgtcac tttttaaata aagtatgtac 1478821 gcacattgcc gaccttgatt ttaacaaaat tcaaatctat gtcggaaact atgatttctg 1478881 gtacgagtca agccagctgg cgttaaagct ttctcaagaa gcgaacaaga aaaaagaaga 1478941 gcagattaaa cagcttcaag agtttgtcgc tagattcagc gccaatgcgt ctaaatctaa 1479001 gcaggctaca tcaagaaaga aacttctcga aaaaatcacg ctggatgata ttaaaccgtc 1479061 ttcccgccgc tatccttatg ttaacttcac gccggaacgg gaaatcggaa atgatgttct 1479121 tcgcgtggaa ggcttaacaa aaacaatcga tggcgtaaag gtgcttgaca atgtcagctt 1479181 tattatgaat cgagaagata aaattgcttt cactggccga aatgaacttg ctgttactac 1479241 gctgtttaaa atcatttccg gggaaatgga agctgacagc ggaacgttta aatggggtgt 1479301 taccacatct caagcgtatt ttccaaaaga caacagcgaa tatttcgaag gcagtgatct 1479361 gaaccttgta gactggcttc gccaatattc tccgcacgac caaagtgaga gctttttacg 1479421 cggtttctta ggacgcatgc tgttctctgg agaagaagtc cacaaaaaag caaatgtact 1479481 ttccggggga gaaaaggtcc gctgtatgct gtcgaaagcg atgctttctg gcgccaatat 1479541 tttaattttg gatgagccga ccaaccattt agacctagag tccattacag cgctcaataa 1479601 cggcttaatc agctttaaag gcgctatgct gtttacttcc catgaccatc agtttgtgca 1479661 gaccattgcc aacagaatta tagaaattac acctaacggc atcgtcgata agcaaatgag 1479721 ctatgacgag ttccttgaaa atgctgatgt gcagaaaaaa ttgactgaac tatacgccga 1479781 ataaaaaagc agagatttct ctgctttttt tgatacctaa atgtgaaagg agatcacaac 1479841 atgaaatttt tggttgtcgg agcaggtgga gtaggcgggt atattggcgg acggctttcg 1479901 gagaaaggaa atgatgtgac atttctcgtg cgccaaaaac gagctgagca gcttaaaaaa 1479961 accgggcttg tcatccatag tgaaaaaggg aatgtatcat ttcagcccga actaatcagt 1480021 gccggagaaa cagggcaatt tgatgtcgtt atcattgctt ctaaagcata ctcgcttggt 1480081 caagtgatag aggatgtcaa accatttatc catcaagaat ctgtcattat ccctttttta 1480141 aatgggtacc gccactatga gcagctattt gcggcatttt caaaagaaca ggtgctgggc 1480201 ggcctgtgtt ttatagaaag tgctttagac aacaaaggag aaattcatca tacgagcgca 1480261 tcgcatcgtt ttgtatttgg agaatggaac ggcgagcgta cggagcggat aagagcgctt 1480321 gaagaggcat tttcaggtgt gaaggctgaa gtcatcatta gcgggcatat cgagaaggac 1480381 atttggaaaa agtatctctt tattgcagcg caagcgggga tcacaacgtt atttcaacga 1480441 ccgcttggcc caatcctcgc cacagaagcc ggacgtcaca cggcccaaac tcttattggg 1480501 gaaatttgca ctgttttacg aaaagaaggt gttccggctg atccggctct tgaggaagag 1480561 agctttcgta cgatgaccag catgtcttac catatgaagt cctccatgct tcgggatatg 1480621 gaaaacggcc aaacgacaga aggcgaccac ctgcatggat ttttgattga aaaagcaaaa 1480681 cgtttatctc tcgctgcacc agtattagaa accgtttatg cgaatctgca aatgtatgaa 1480741 gcagaaaaat aaaaaaagga ggcggaaaag cctcctttta tttacttaaa aagcccaatt 1480801 tccgtttctg aagataggct ctcttttccc gtctgccgta attccgtcaa tattcatatc 1480861 cttagaaccg atcataaagt ccacgtgtgt aatgctttca tttaggcctt ctttgacaag 1480921 ctcttcacga gacatctgct ttccgccttc aatattaaag gcataggcgc ttccgatcgc 1480981 caaatgattt gacgcgtttt catcaaacag cgtgttatag aaaagaatgt ttgattgtga 1481041 tataggcgaa tcgtaaggaa caagtgccac ttcacctaaa tagtgagaac cttcatctgt 1481101 ttccaccagt tcttttaaaa tatcctcacc tttttcagct ttaatgtcga ctatacggcc 1481161 attttcaaac gtcagggtga aattttcaat aatatttccg ccgtagctta atggttttgt 1481221 gcttgatacc actccgtcaa ccccgtcttt ttgcggcagc gtgaacactt cttctgtcgg 1481281 catattggcc ataaactcat ggccactttc attcacgctt cccgcacctg cccaaacatg 1481341 cttcctaggc agcttaattg ttagatcagt tccttctgct tgataatgta aggcagcgta 1481401 atgtctctcg ttcaaatggt caactttttc atgaagattt tggtcatgat tgatccacgc 1481461 ctgaaccggg ttgtcttcat ttacgcgcgt cgctttaaaa atttcttccc acagaaggtg 1481521 gatcgcttcc tcctctgatt tgccaggaaa caccttgtga gcccagcctg ctgatgccgc 1481581 acctacgaca gtccagctga ctttgtctga ttgaatatat tgtctgtatg tatgtaatgc 1481641 tttgcctgct gctttttgga atgccgcaat ccgtttggaa tctatacctt ttagcaagtc 1481701 tgggttcgac gacacaacag aaatgaaagc agctccattt ttggcaagct cttctctgcc 1481761 ttttgcttcc cattcaggat attcttcaaa tgcttcaaac ggcgcaagtt cgtattttaa 1481821 tttggcgact tcgtcatcct gccaattcac ggtgacgttt tttgcgccct tttcatatgc 1481881 gtgttttaca attaaacgga caaaatcccg aacgtctgtt gaagcattta cgactacata 1481941 ctggcctttt tggacattaa cgccgacttc taccgccagc tgtgcatatg tatttaattt 1482001 ctgtgaaaat gaatccatga atcattcctc caagcttttt tctcatcata tcaaatatga 1482061 tcctataaag gaaagaagga gcccaaagtg aaaaacccaa aacgacacgt cttgggtttt 1482121 ttcaatatta tggatgattc agttttacag tgccgcctgc aggcgaatgg ggcatatttg 1482181 ccaaagaaat gctcatgcct ccaagaataa ttccgcttaa aatggctgcg atcgctactc 1482241 ttcttcctaa atctcttagc atctgtttcc tccttaacgt ttctccattt cccacaatat 1482301 gaaggaagtg aggaaaaaag aagcaagaaa tttgccgcgt gtgagaattt tgcgggtaaa 1482361 gactatttaa ttgccttttg cagcttatca atcacttcta aagaacggcc tgtgccgatt 1482421 gctacagatt caagcgggtt ttgcgccacg tgtacaggca cgacaatctc ttctgtgagc 1482481 cattctttaa ttccattaag gagcgcgccg ccgcctgtta aaataacgcc gcgatcaaca 1482541 atatctccgc tcaattcagg cggacagtcc tcaagtgtcg ctctgatggc ttcaagaata 1482601 tgcaggaggg attcacgcat tgcatcttga atttcgttgg attgaagcat aatggttttt 1482661 ggaagacctg tcacgaggtc acgtccccga atttccattg cctctggtat atgttcaatc 1482721 agagcatggc caatttccat ttttacctgc tcagctgtgc gttcgccgat cagcaaattg 1482781 tattttttac ggacgaaaga aacgatatcc tcatcaagct ggtctccgcc gatcctgata 1482841 gaatggcagg aaacaacgcc accgaaggaa ataatagcga cctctgtcgt ccctccgccg 1482901 atatctacta ccacattggc aaccggctca tcaaccggta aatccgctcc gatggcggct 1482961 gcaactggct cttcgattaa atgaacgttt ttcgcgccgc aatttttcac cgcatcactg 1483021 atggcgcggc gttctactgc tgttgagcct gatggtgtgc aaacgactac gttcggtttt 1483081 ctgaacgaca tgccgatgct ttttgcggct tttttcataa tgtgctttag caggtcagtt 1483141 gtcatatcat agtctgcgat cacgccatct ttcatcggtc tgacagcgac aatttttccc 1483201 ggtgttttac cgatcatgtt tttcgcgtca gctccgattg caagcactgc ttttgtcgtc 1483261 gtatccactg cgacaacaga tggttcattt aggataatcc ctttattttt gctgtaaaca 1483321 agtatattag ctgttcctaa gtcaatcccg atttcagttg attgaaacat gttttcaccc 1483381 aatctctatc ctaatttaat atgattctac atttaaagtt tctcagaaat actgcgattt 1483441 ttgggggtgt gcgtcggtaa agaaatgttt ttgtaaaaaa tcaaggaact gtgtaacaga 1483501 agtaatacat ttttcggttt tatggaaaaa atatcttgta attcttatag aaagcgggaa 1483561 actttttcaa agtttcattc gtctacgata tattgaggta catccttaaa acattacatg 1483621 agaaaagaaa catttaaagg aagaagggtt tttatgaaat caataggtgt tgtgagaaaa 1483681 gtagatgaat taggccgcat tgtcatgccg attgagttga gacgggcatt ggatattgcc 1483741 ataaaagaca gcattgagtt ttttgttgac ggagataaaa ttatcttgaa aaagtacaaa 1483801 cctcatggcg tttgtttaat gactggagaa atcacttcag aaaataaaga atacggcaac 1483861 ggtaaaatta cgctaagccc tgagggtgca cagctgcttc tcgaagaaat tcaagccgct 1483921 ttaaaagaat aaaattatgc taaaaaaggc ggagtgatat catctccgcc ttttttgcgt 1483981 gccaattttt gattaccgcc gcctaagata agacatcaag atatttggta atgaatgatt 1484041 tgggatactt tacatatttt actcaattat ttgtcgaaga atggtacaat aagtagagaa 1484101 acacaagcgg caggtggtca tatgagaaaa tatcaagctc gtatcatttc catcattttg 1484161 gcaatgattt ttataatgtt ttgggattat ttattttatt ttataggcaa aaacccgatt 1484221 aattggcctg ttgatattgt gtatactgca gtcacgctgg taagtgtctg gatgttggct 1484281 tattatattg atgagaaaca gcagctggtt aagaaaatga aggataacga atggaagtat 1484341 aaacagcttt ctgaagaaaa aaaccgcatc atggataatt tgcaggaaat cgtatttcaa 1484401 acgaatgcaa aaggtgaaat tacatattta aaccaagcgt gggcatctat aaccgggttt 1484461 tcaatcagtg aatgtatggg aacaatgtat aacgattact tcataaaaga aaagcacgta 1484521 gccgaccaca ttaacaccca aatccaaaac aaagcgtctt ctggcatgtt tacggcaaaa 1484581 tacgtgacaa aaaacggcac gattttttgg ggagaagttc attataaact ttactatgac 1484641 cgggatgacc aatttacagg cagcctgggt acaatgtcag atatcactga gcggaaagag 1484701 gctgaagatg agctcattga gattaatgaa cggctggcga gggaatccca gaaactatca 1484761 atcacaagtg aacttgccgc aggtattgct catgaggtca gaaacccttt aacatctgtc 1484821 agcggtttcc tccagattat gaaaacacaa tatccggaca gaaaagacta ttttgacatc 1484881 atcttttcag agattaaaag aatcgattta gtgctcagcg agctgctgct gcttgcaaaa 1484941 ccgcaggcaa tcacatttaa aacacaccag cttaatgaga tcttgaaaca agtcacgaca 1485001 ttgcttgata ccaatgcaat tctgtccaat atcgtcatag agaaaaattt caaagagaca 1485061 gatggctgta tgattaatgg agacgaaaat cagctgaagc aggtctttat caacatcatt 1485121 aaaaacggaa ttgaggcaat gccaaagggc ggtgtcgtaa ccatttcaac tgctaaaacc 1485181 gcctctcatg cagtgataag cgtaaaggat gaaggaaacg gcatgccgca ggaaaagctg 1485241 aagcagattg gcaaaccttt ttattcaaca aaagaaaagg gcactggact gggacttccc 1485301 atttgtttga gaatcctgaa ggaacatgac ggggaattga aaatcgaaag tgaagctgga 1485361 aaaggcagcg tctttcaagt ggttttgcct ttaaaatcag acagctgaga ggagaaaaat 1485421 aaagtgaact cgcttctgtt tgtatacggg acattaagaa agcatgaaaa aaaccatcat 1485481 ttgctggcac aatcggcatg tatcaatgag caggcgagaa caaagggaag tttgtttgct 1485541 gcaaaagagg ggcccacagt tgttttcaat gatgaagatg aaggctatat atatggcgaa 1485601 gtatatgaag cagatgaatt gtgtatacat aagctcgatc aattttttca aggatatcat 1485661 aaacaaacgg tgtttgtaga aacggatgtc gggattaaaa ttgcgcttat ttattttatg 1485721 aacaaagacg ggtgtgccgg ttttacgaaa ataagcagcg gcgactggaa agaacatcag 1485781 atgatcagca aatcgaaaaa tcccatttat tattttgcct atggatcatg catggataat 1485841 gcccgctttc aaaaagcggg agtcgatcac tattttcaag atccagtagg aagagctgtt 1485901 ttaaaaggat acacaacccg cttcacgcta aaaagggaag acggttcaag agcggacatg 1485961 ttggaagacg gaggaacaac agaaggcgtt ttataccgta tcccttattc tgctctctcc 1486021 tatctatata aaagggaggg cgtcgaatct cttacgtatc ggccggcatt tgtagacgtt 1486081 gaagctggcg gaaggcacta caaagactgt ttaacctttc tcgtcctcca aaaagaagcg 1486141 gaaattgccc cgcctcagca ctatcagatt gaaatcgaac gcggagcgga gctgtatttg 1486201 tcgcctgagt ttactgaaaa gctcaagcgg catatgaatt cgctgccaaa aggataacac 1486261 tgtaacaaaa gaatatgata aaatttgatc aatatcatgt catataaagg agcaccacga 1486321 tgaaaaaaga atttgcggta attgggctgg gccgttttgg tggcagtatt tgcaaagcat 1486381 taagcgaaga aggcgtcgag gttatggcaa tggatatcga tgaagataaa gtcaacgagt 1486441 atgccaagat tgcatctcac gcagttatcg gtgattcgac agacgaatct gtcctgaaaa 1486501 atttaggcct gcgaaatttt gaccacgtta ttgtagcaat cggggaaaat attcaagcga 1486561 gtattttaac gacactcatt ctgaaagaac ttggcgtcca tacgattaca gttaaagcgc 1486621 agaacgatta tcacgaaaaa gtgctgtcta aaattggtgc ggatcacatc gtccacccgg 1486681 aacgcgatat ggcaaaacga attgcgcata atatcgtgtc caacaatgta cttgactatt 1486741 tggagctgtc tgaagagcat agtcttgttg aaatcgtagc taacagccgc ctggctggaa 1486801 atacgcttct cgatttagat attcgcgcaa aatacggtat taacatcgta gccataaaaa 1486861 ggggcaagga agtcatcgta tcaccgcttg caaccgaagt catccaccaa gaagatatac 1486921 tcattgttat tggatcagtt acagacatct cccgtttcga aaaaagagtt cttcatacaa 1486981 aatagcagcc aaataagccg tcctcaaagg gcggtttttc atattatcag aatataacaa 1487041 ctttaatgaa ctgagcgtca atttcttaaa atttcattga ctaagcacag gcgttccgat 1487101 agcatattgt accatataat aaaaaaagga ggggcctatt tgaataaaga agcgctagtc 1487161 aataggctga atgcttcagc caaaagacaa aaagctgata tcgtcattaa aaacggaaaa 1487221 atcatggacg tatataatca agaatggata tatgaagata ttgcgattac agatggagtt 1487281 attgtaggcc tcggtgagta tgaaggcgaa aatatcattg atgcagaggg acaaatgatt 1487341 gttccgggtt ttattgatgg acatgtacat attgagtcgt caatggttac accgattgag 1487401 ttcgctaaag cagtgttgcc tcatggcgtg acgacggttg ttacagatcc gcatgagatc 1487461 gcgaatgtgt ctggtgaaaa agggattgag tttatgcttg aacaagctcg gcatacaccg 1487521 ctgaatatcc attttatgct tccttccagt gtgcctgccg caagttttga gcgatcaggc 1487581 gcaattctca aagctgccga tctcaagcct ttttatgaag aagaagaagt attagggctg 1487641 gctgaagtta tggattatgt gtcggttcag caggctgaaa aagacatggt tcagaaactg 1487701 cttgatgccc gtgtggcagg aaaaaggata gacggtcatt tagctggttt atcaacagac 1487761 ctcattaaca tttacagaac cgcatttgtc ttaaacgacc atgaagtaac atcgaaggaa 1487821 gaagcccttg atcgtatcag aaggggcatg tatgtcatga tgcgtgaagg atcagtcgcc 1487881 aaaaacacgc tcaatgtgct gccggcggtg aatgaaaaga acgcacgccg gttctttttc 1487941 tgtacggatg ataagcatgt ggatgattta ttgtcagagg gaagtgtaaa ccatcaggtg 1488001 aaaatggcga ttcaagccgg acttaatccg tttttagcct atcagctagg aagcctcaat 1488061 gcagccgaat gctacggatt agatacaaag ggagcgattg ccccgggttt tgacgctgat 1488121 ttgctttttg tatctgatct ggaaaatgtc actgtcacaa tgacgatggt aaaagggcag 1488181 actgttgctg aagacagcaa agcggtctat caggatcatg cttcaactgc agcaccagat 1488241 caggcactgc ttgattctgt taagcttgct gctcctctta acaaacagga ttttcatatg 1488301 ccaatcgatt cagagcagca gatcaatgtc attcaaatca taccaaatca gcttgaaaca 1488361 cgattagtac aagttccggc tcctgttgcc cgcgaatttg agcctgacac tgagcttgat 1488421 ttgttaaaga ttgcagttgt cgagcggcat aaaggattaa aagaaaccgg acttggtgtt 1488481 gtgaaaggtt ttggattcaa gagcggagcg attgccacaa ccatttcaca cgactcccat 1488541 aatattattg ccgtcggaac gaatgatgag gatatcgcgg cggcagttaa taagctgcag 1488601 gaaattggcg gaggattaac aattataaaa aatggggaag agctccattc agtaccgctg 1488661 ccgattgcag ggttattatc cgaccaatct gcagagcaag tgaatcaaag cttgctgacg 1488721 cttcatgata aattgtcgtt aatcggtttc acaggcggat ttaatccatt tttgacattg 1488781 tcgtttttag cgttgcctgt cattcctgat attaaaatga cgactacggg attattcgat 1488841 gtaaaatcat ttcaacacat atcactgcaa taaaaagagg cactccctta gggagtgcct 1488901 ctttttttaa acctccataa tgatcggcag gatcattgga cggcgctttg ttttttcgta 1488961 caagaaaggt gcaagcgtgt ctgtaatttc gtttttgatt tcagaccatt gagtcgtttt 1489021 tcgttccatt actttttgta agtgatttga aatgagctct tgagcgtcgt tgatcaagtc 1489081 accagattct ctcatgtaca caaatcctct ggaaatcaaa tcaggacccg ctgaaatctt 1489141 gaagtcgtcc atgtcaatgc tgacaacaac gatgacaagt ccttcttcag agagaattct 1489201 gcgatcacga agtacgatat tgccaatatc accgataccg cttccgtcaa tgtacactga 1489261 accggacggg atttttcctg caactgaagc ctcatcgcct ttaagtgcta atacttcacc 1489321 attatccatg ataaagcagt tttcctctgg gatgccacaa tctgttgcaa gtttgacatg 1489381 catcttttgc attctgtact caccgtgaat cggcatgaag aatttaggct tgattaaacg 1489441 aagcatcagc ttctgttctt cctgtccgcc gtgaccggat gtatggatat cgttaagagg 1489501 gccgtgaata acctcagcac ccgcacgata cagctggttg attgttcgac tcacgctgat 1489561 tgtgttgcct gggatagggg atgaagaaaa tacgactgta tccccaggat tgattgaaat 1489621 ttggcggtgt gtgccgtttg caattcttga taacgccgcc attggttccc cttggcttcc 1489681 tgtacataaa attgttactt tattagcagg catacgattg atttcgttat gctcaataaa 1489741 cgtattttta ggacagttaa tataaccgag tgtctgtcca atttcgatag ccgattccat 1489801 actgcgtcca aatacggcaa cttttcttcc attttgtaca gcagcttcaa ttacctgctg 1489861 caagcggtga atattcgacg caaatgtggc gaagataatt cggccgtcca ccttgcggaa 1489921 aatgtcatga atgctttctc ctacacggcg ctcagacatg gtaaactccg gattttcact 1489981 gtttgtgctg tctgaaagaa ggcacaaaac gccttcttta ccgatttcgg ccattttcgt 1490041 taagtttgcc ggctcgccga ctggagtaaa gtcgaatttg aaatccccag tatgtacgat 1490101 gtttccgggc ggcgttttta caacaatgcc gtaggaatcc ggaatactgt gtgttgttct 1490161 gaagaatgac acagccgttt tgcggaactt tacaatatca tcctcgccga taatgttcag 1490221 tttcgtctgt ctcaataatc catgctcttc aagtttattc cgaagtaagc cgatcgcgag 1490281 ttttccgccg tatacaggaa tattcacttg tctgagcagg tatggaatac cgccgatgtg 1490341 gtcttcgtgc ccgtgggtga taaaaagccc tttaatttta tcttcgtttt tgactaaata 1490401 cgtataatca gggatgacgt agtcaattcc gagcagttcg tcctcgggaa acttgatccc 1490461 cgcatcaatc agtacaattt catcctggaa ttgcaccgcg tacgtatttt taccgatttc 1490521 gcccaaacct ccgagggcga aaacagcagt ctgatcattt tttacaaatt tcataccgct 1490581 cataactcca atactttaaa attttcgctc tgttgttcat attctaagaa tgcaccatca 1490641 acaggtgtaa taaactcaat attaaatttc ttttctttca gctttgttct gacgtcacgc 1490701 tcagatacgc cttcaatata aagtgaatct gtcttttccc gaacaggtac ttcgtcagcc 1490761 ttctcttgat aaaatacctt ataaatcatt ccaaatctct ccttaaatgc cgtatgttag 1490821 actcgctcat tctattatat tcgaaaacgg aatataagga aagccttgag caaaataagg 1490881 atctctcaaa aagtgaaaga tcccttgtca ggcaattgct ttcttacgga gcattccgtt 1490941 ccattgtctt ctgagtttct ttcttaattt acgcagcatt agccagtccc tcctttaatg 1491001 aaaaatttgt cccagagttc ttttatacaa atagtatacg gagattgagg aagacttttc 1491061 gtggttatta atggaattta atatgatttt tgaacgaaat tgtttgctga atgacaatct 1491121 ttttgtatga tgagggtggg aattgcagac caagacgata aaggggaagt tgcgatggat 1491181 tctaaattaa tcttttttga tattgacggc acaatatatg atcatgataa gaatataccg 1491241 gaaagtacga gaaaaaccgt ggcggagctt cagcgccaag ggcatcatgt gtttattgcc 1491301 agcggccggt ctccattttt ggttaagccg attttggagg agctgggcat ccactcattt 1491361 atttcctaca atggacagtt tgttgtcttt gaaaatcaag tgatttataa aaatccgctg 1491421 cctgaaaatg caatcaggcg attattaaag caggcggatg aaggcaagca tcctgttgtg 1491481 tttatggctg aggacacgat gaaagcgact gttgcggatc acccccatgt tctcgaggga 1491541 atcggcagcc ttaaaacaga ttatccagag accgatgacc ttttttatga aggaaaagaa 1491601 atttttcagc ttcttttatt ttgtcaggat gaagaagaaa aagcttatgc cgcttttcct 1491661 gagtttgatc tagttcgctg gcatgagcta tcgactgatg ttctgccgca cggaggttcg 1491721 aaggcagaag gaatcaaaaa agtgattgag cgtcttccgt ttgatatcgg cgatacatat 1491781 gctttcggcg acggattaaa tgatttgcaa atgattgaat acgttgggac aggcgttgct 1491841 atgggaaatg ctgttcccga actgaaagaa atcgcggact ttgtaacaaa accggtggac 1491901 gaggatggaa ttgcatacgc tgtcaaagaa ttgggccttt taaaataaag aaacggctgg 1491961 cattgtgcca gccgttttct cttttagcgc tcaattgcga ttgcattttc aggttctttg 1492021 aaaggatttt ccttatcaat atgatcatag aacataacgc cgttcaaatg atcgatctca 1492081 tgctgaaaca caatagccgg aaatcctttt aaacgaatat caatattttc gccttctagt 1492141 gttgttcctt ttactctgat gcgagcatag cggggaacat aaccgggaat cgcttcatcc 1492201 acagagaggc agccctcgcc gcttgttaag tagctttttt caactgaatg gctgacgatc 1492261 ttaggattaa acagagcata gctgtataat ttaccggaag catcttccgc atgaacggcg 1492321 atcattcgtt ttttgatatt aatttgagga gctgcgagtc ctacgccagg gcgcagcttg 1492381 tatttttcgg ctaattctgg attttggctg tttttaacaa attcgatcat gtcggccagc 1492441 tgctgttttt ctgcatcagt tggaggcagc tcaacaggtt cggcagtctc tctgagggct 1492501 ggatggccgt cacgtacgat gttttccata gtaatcaaga aacttcactc ctaaagctta 1492561 atatgtaaat tatatcggat ttcttcacaa aggtgcaacg aaacgaatga ccagccgtat 1492621 atggctggtc aatttcatgc tgtgtggtta gcaacagcct ccacctaaat aagcagctcc 1492681 gacaatgatt aacagaatga ataaaacaac gattagcgca aaggtgcggc cgtagccata 1492741 tccgcagcca ccatatccgt aaccaccata actgcagcag cctccgccgt aaccatatcc 1492801 atacatatta cataacctcc tcttttaatt acgccagagc ctttataagt aggcatagcg 1492861 tctaatataa cctatgtaaa aacaaaaaag ttgtatggtc atctgtcctg atttttcact 1492921 tttttgattt aatttcagta ttgcatttat acagcacggc tattgccaaa tgtccccatg 1492981 gattctatag tagaaattgt caagattggg ggatttaacg tgaaagacgc tataaaacgg 1493041 cggcctggaa tcaagatcgg agctttttgt gccatggcac tgatattaac aggatgcatg 1493101 ggacaggacc cggttgattc acttcatcat tcattagaaa aagccgcgga atcggaaaag 1493161 ccgtttcaag aagaacaaaa cacactcaaa gaattagagg ccaaagaaaa tcagctttac 1493221 gatagtgtta tgaagctcaa tatggatgat tataaaaaaa ttgttgcttt atctaataag 1493281 gcgcttgaaa atgtcagcaa gcgcgaagaa cacctaaagc ttgaaaatga cagcatgaaa 1493341 aaatcggaaa cagaatttga ggaagcaaaa acgtcagcgg aacatattaa ggaaaaagac 1493401 ataaaagaaa aggccgatgc cgcagcaaac catatggaga aaagatatac atcatatggc 1493461 actatgtata aagagtataa aaaagcgctt gagcttaata aaaaactgta tatgcagctg 1493521 aaagacaaag atttgacaag agatgatctg gatcagcaga tcgataaagt caatgcttct 1493581 tatgaaaaga tccttaaata tagcggagaa tttaatgaac aaaccgaaaa atataataaa 1493641 gcccgggaag atttatatga tgctgcaggc tatcgtgtga aaaagagctg actcgatcag 1493701 ctcttttttt gaatgaaatg cgattcggat ttcgttcaaa attttcattt ctattgtagt 1493761 acagcatagt aaggtatact agtacagttt tgggtgcggt tggcatctgt ttttttgatg 1493821 aaaatgtaaa gcgaatacat ttattgaaaa tcagcgatga aaacgattga cggttcttct 1493881 ttatttggtg taaactaatc catgttaagc ggtgttgtat tagtttttta caacttcgaa 1493941 ataatacagt tcaaagcaga gtgtaactat cctacataaa aggttttggc aaactgggga 1494001 tcggctaaaa tataatacga cttactgctg atactttagg gtaccctaag tttgtatgta 1494061 taaaaggaat gcacgtctaa tgactgttta aaagaaagga agaggtgact tagtatggct 1494121 gcaaaaacga aaaaagctat cgttgacagt aagaagcaat ttgatgccat taaaaagcag 1494181 ttcgaaacgt tccaaatttt aaatgaaaag ggagaagtcg tgaatgaagc ggcgatgcct 1494241 gatttaactg atgatcaatt aaaagagcta atgcgccgca tggtatttac gcgtgtgctt 1494301 gaccaacgct ctatctcatt aaaccgtcaa ggacgtctcg gattttacgc tcctactgcg 1494361 ggtcaagaag cttctcagat tgcaacgcat ttcgcgcttg aaaaagaaga ctttgttctt 1494421 cctggatacc gtgatgtgcc tcagttaatt tggcacggcc ttccattata tcaagcgttt 1494481 cttttctctc gcggacattt cagaggaaac caaatgcctg atgatgtgaa tgccctttct 1494541 ccacaaatca ttatcggtgc tcaatacatt caaactgccg gtgttgcgct aggtcttaaa 1494601 aaacgcggta agaaagctgt cgcaatcact tacactggtg acggcggagc ttctcaaggg 1494661 gacttctacg aaggaattaa ctttgccgga gcttataaag cacctgcaat cttcgtggtg 1494721 caaaacaacc gttacgcgat ttcaactcct gttgaaaaac aatctgcagc tgaaacaatt 1494781 gcacaaaaag ctgtagctgc cggtattgtc ggcgtacaag tagacggaat ggatccgctt 1494841 gctgtatacg cagcaactgc tgaagcacgc gagcgcgcaa tcaacggcga aggtccaaca 1494901 ctaattgaaa cacttacatt ccgttatggc ccgcacacaa tggctggtga cgatcctact 1494961 aaatatcgta caaaagaaat cgaaaatgag tgggaacaaa aagatccgct tgtacgtttc 1495021 cgtgcgttcc ttgaaaacaa aggcttatgg tctgaagaag aagaagcaaa agtgattgag 1495081 gatgcgaaag aagaaattaa gcaagcgatc aaaaaagctg atgctgaacc gaagcaaaaa 1495141 gtaactgatt taatgaaaat catgtacgaa aaaatgcctc acaaccttga ggagcaattt 1495201 gaaatttata cacagaagga gtcgaagtaa gccatggcgc aaatgacaat gattcaagca 1495261 atcacggatg cgttacgcac agaactgaaa aatgacgaaa atgtcttagt tttcggagaa 1495321 gacgttggtg taaacggcgg cgtattccgt gcgacagaag gattgcaaaa agaattcggt 1495381 gaagaccgtg tgtttgacac gccacttgct gaatctggta tcggcggtct tgcccttggt 1495441 ttaggcttaa acggcttccg tccggtaatg gaaatccaat tcttcggatt tgtttatgaa 1495501 gtaatggatt cagtttctgg ccaaatggct cgtatgcgct accgttctgg cggacgctgg 1495561 acttcacctg taacaattcg ttctccattc ggcggcggtg ttcatactcc tgaacttcac 1495621 gctgacagct tggaaggtct tgttgcacaa cagcctggta tcaaagttgt tattccatca 1495681 actccttacg atgccaaagg acttttaatt tctgcgatca gagacaatga tcctgttgtc 1495741 ttcttagagc atatgaagct ttaccgttct ttccgtcagg aagttcctga agaagaatac 1495801 acaattgagc ttggaaaagc tgacgtgaaa cgtgaaggta ctgatctttc aatcatcact 1495861 tacggcgcaa tggttcatga atcattaaaa gctgctgatg agcttgaaaa agacggcatt 1495921 tctgctgaag ttgtcgacct tcgtacagta agcccacttg atatcgatac aattatcgcc 1495981 tctgtagaaa aaacaggacg cgcgattgtc gttcaagagg cacaaaaaca agccggtatt 1496041 gctgcaaacg tagtagcaga aattaatgac cgtgcgatcc tgagcttgga agcacctgta 1496101 cttcgcgttg cagcgccaga tacagtattt cctttctctc aagcggagag cgtatggctt 1496161 ccaaaccata aagacgttct tgaaacagca agaaaagtgc ttgaatttta atcaaactgc 1496221 ataatcgaga gggaagatga acgttttccc tctattatat atctgttttc aatgcttacg 1496281 atgtaaactt taaaattgct taatcaaact aggaggtcga gaactgtggc atttgaattt 1496341 aaacttccag atatcgggga aggtatccac gaaggcgaaa tcgtaaaatg gtttgtcaag 1496401 cctaacgacg aggtagacga agatgatgta ctggctgaag tccaaaatga taaagcagta 1496461 gtagaaattc cttcacctgt taaaggaaaa gtattagaat taaaagttga agagggaacg 1496521 gttgcaactg ttggacaaac gattattacg tttgatgcac ctggttacga agatcttcaa 1496581 tttaaaggca gcgacgagtc tgacgatgcg aaaactgaag cacaagttca gtcaactgca 1496641 gaagctggac aagacgttgc gaaagaagag caagctcaag agcctgcaaa agctactggc 1496701 gcaggacagc aggatcaagc tgaagttgac ccgaacaaac gcgtgatcgc tatgccttcc 1496761 gtacgtaaat atgcacgtga aaaaggtgta gacatccgta aggttactgg ttcaggcaac 1496821 aacggacgtg ttgtaaaaga agatatcgac agctttgtaa acggaggagc gcaagaagct 1496881 gcaccgcaag aaacagctgc accacaagaa acagctgcta aaccggctgc tgcaccagct 1496941 ccagagggcg aattcccaga aacacgcgaa aaaatgagcg gtatccgtaa agcaattgca 1497001 aaagcgatgg ttaactctaa acacactgct cctcacgtaa cgttaatgga cgaagtggac 1497061 gtaacaaacc ttgttgcaca tcgtaaacag ttcaaacagg ttgctgctga tcaaggaatc 1497121 aagctgactt acttgcctta cgttgtaaaa gctcttacat ctgcactgaa aaaattccct 1497181 gttttaaaca cgtcaattga cgataaaaca gatgaagtca tccaaaaaca ttacttcaac 1497241 atcggtatcg ctgctgacac tgaaaaaggc ttgcttgtac cggttgtgaa aaatgcagat 1497301 cgtaaatctg tctttgaaat ttctgatgaa atcaatggcc ttgcaacaaa agctcgtgaa 1497361 ggcaagcttg ctccagctga aatgaaaggc gcatcttgca caattacaaa catcggttct 1497421 gccggcggac aatggttcac tccggttatc aaccatccag aagttgcgat tcttggtatc 1497481 ggacgcattg cagaaaaagc gattgttcgt gatggcgaaa tcgtagcagc tccagtctta 1497541 gctctttctc tcagcttcga ccaccgtatg atcgacggag caactgcgca aaatgcatta 1497601 aatcacatca agcgtttact gaacgatcca caattaattt taatggaggc gtaatgttat 1497661 ggtagtagga gatttcccta ttgaaacaga tactcttgta attggtgcgg gacctggcgg 1497721 ctatgtagct gccatccgcg ctgcacagct tggacaaaaa gtaacagtcg ttgaaaaagc 1497781 aactcttgga ggcgtttgtc tgaacgttgg atgtatccct tcaaaagcgc tgatcaatgc 1497841 aggtcaccgt tatgagaatg caaaacattc tgatgacatg ggaatcactg ctgagaatgt 1497901 aacagttgat ttcacaaaag ttcaagaatg gaaagcttct gttgtcaaca agcttactgg 1497961 cggtgtagca ggtcttctta aaggcaacaa agtagatgtt gtaaaaggtg aagcttactt 1498021 tgtagacagc aattcagttc gtgttatgga tgagaactct gctcaaacat acacgtttaa 1498081 aaacgcaatc attgctactg gttctcgtcc tatcgaattg ccaaacttca aatatagtga 1498141 gcgtgtcctg aattcaactg gcgctttggc tcttaaagaa attcctaaaa agctcgttgt 1498201 tatcggcggc ggatacatcg gaactgaact tggaactgcg tatgctaact tcggtactga 1498261 acttgttatt cttgaaggcg gagatgaaat tcttcctggc ttcgaaaaac aaatgagttc 1498321 tctcgttaca cgcagactga agaaaaaagg caacgttgaa atccatacaa acgcgatggc 1498381 taaaggcgtt gaagaaagac cagacggcgt aacagttact ttcgaagtaa aaggcgaaga 1498441 aaaaactgtt gatgctgatt acgtattgat tacagtagga cgccgtccaa acactgatga 1498501 gcttggtctt gagcaagtcg gtatcgaaat gacggaccgc ggtatcgtga aaactgacaa 1498561 acagtgccgc acaaacgtac ctaacattta tgcaatcggt gatatcatcg aaggaccgcc 1498621 gcttgctcat aaagcatctt acgaaggtaa aatcgctgca gaagctatcg ctggagagcc 1498681 tgcagaaatc gattaccttg gtattcctgc ggttgttttc tctgagcctg aacttgcatc 1498741 agttggttac actgaagcac aggcgaaaga agaaggtctt gacattgttg ctgctaaatt 1498801 cccatttgca gcaaacggcc gcgcgctttc tcttaacgaa acagacggct tcatgaagct 1498861 gatcactcgt aaagaggacg gtcttgtgat cggtgcgcaa atcgccggag caagtgcttc 1498921 tgatatgatt tctgaattaa gcttagcgat tgaaggcggc atgactgctg aagatatcgc 1498981 aatgacaatt cacgctcacc caacattggg cgaaatcaca atggaagctg ctgaagtggc 1499041 aatcggaagt ccgattcaca tcgtaaaata attttcatat caaaaacagc cccgctttga 1499101 gcgagggctg tttttttatt ttgacagcac atgctgtaat ggtttaatga tgtcttcttt 1499161 ctttttcaca catccctcga ttttcaccac gacatggcgc tgatcaacaa ccataagggt 1499221 agggacagtt tcaatctcat cttcccagcc ttctttttta tcatagacct tcattttatc 1499281 tatttgctcg ggataatctt tttctaaatc aagcagtgca tcgtaataag gcgcttcctg 1499341 gtctatttgg ttctcatcag aaaaaaacag gatttgtgta tgatgaatgt tgtcaatccg 1499401 gctttttttc atcggattga tggtggaaag cgtacagccc gataaagcaa atactattat 1499461 cagcatgggg aataccgcgc gatatcgcat ctatcttctc ctctgtataa acagtagtta 1499521 actagcttta gtttatcacg agagacggct taatctgctt cttgttacct aattgttata 1499581 taattgaaac cgtttttaaa gtgagattac atattatatc aatcgtttaa aatagcaacc 1499641 tggggtatat tgaatttttt gctgcattct tggatgaaag ttcaagaaaa cgtgcaatta 1499701 cattatgtgc tgtggcatat atatcgagta aagcttctgt atgaagaaga tattgtatga 1499761 tggaaaatgg aaaaacaagg tgaatatgat gatatgaaat aaaatgtgtt atacagtttg 1499821 ttgttgacat tttaaatgtg acatattaat ataataacaa caaaagaaat taagcgtttt 1499881 caaatttcaa agaaatgggg aataagagat gggtacgatt gtttgccaag attgcaacga 1499941 agccattcat tactttgaag atgagaaagt gacaacatta tatggaactt gctgcggaca 1500001 atgtcaatgt cctgttgatg aagagtaaaa aaaagcatgc ggcttaaagc cgcatgcttt 1500061 ttatttttta ttgaattgct ttttgttctt tgatgacccg gatcatatgt aaagtcgagt 1500121 cctcaggtcc ttgaacaggg aggcctgcgt caaggttttt aaaaatgtag ctgatgtttt 1500181 cttctgtaat aatttctcct gggatgaaga ttggaatacc aggcggatat accatgacaa 1500241 attcagcaat aatccgtccg gatgcttctt ttaatgggat gacttccgta tttgcataga 1500301 aagcatcacg cggagtcatt gccaataaag gtatttctgg aagcagaacc tcagtttgct 1500361 gatgtgttac atcttgttct gacatttgct gtgcgatctc agttaaagcc tctacaagcc 1500421 ggtctgcatc attttggctg tcaccaggag tgaaaataca caaaatattg tacagatcag 1500481 aaagctccac ctcaatatta aaggattcac gaagccattt ttccacgtca tgtcctgtca 1500541 ggccaagact tttcacagag ataatcaatt ttgtcggatc atagctgtaa gctgctttcg 1500601 acccaagaat ctcagaaccg acacaataaa tgccttcaat ctgattgagg cgatctctcg 1500661 tctgattggc aagcttgagt gtttcctcag caagctggcg gccttctgtt gcaaggcgtt 1500721 ttctggcaac atccaaagaa gcgagaagca agtaagaagt tgacgtagtt gtcagcatgc 1500781 tcaggatgga ttgcactctg tctttagata caaggccttc tctcatgttt aaaatagagc 1500841 tttgtgtcag tgatccgccc agcttgtgta cacttgtcgc tgctatgtcc gctcctgcct 1500901 gcatagccga tagcggcaat tcgtcgtgaa aatgaatgtg aacgccgtgt gcttcatcca 1500961 caagcactgg cacatcaaac gaatgagcga gttctacgat gctttttaag tcggctgcaa 1501021 caccgaaata tgtcgggttg atgacgagaa gcccttttgc atccggatgc tcggtaagcg 1501081 cccgtttagc agattcaagt gtaattccgt gggagatgcc caattcattg tcaatttcag 1501141 gatgaataaa aattggaacc gctccggaaa atacaatagc tgtcataatt gatttatgaa 1501201 catttcttgg aataataatt ttatcaccag gtccgcaaac agccattacc attgtcataa 1501261 tggcgccgct tgttccttga acagaaaaaa atgtatgatc cgctccaaat gcttcagcag 1501321 ccagatcttg tgcttgttta ataatgcctt ttggcgcgtg cagatcgtct aatggttcaa 1501381 tattaatcaa atctatgctt aacgcgtttt caccgataaa ttgtctgaat tctgggtcca 1501441 ttcctgcccc ttttttatgg ccgggaatgt ggaattgaac aggctgtctg cttgcatgct 1501501 ttttcagtcc tgtgtataag ggtgtttcat gttgcgacaa ttgttttccc acctttgtaa 1501561 tcatacctat gcataatagt gtgtattaaa atcagtttct caaccgtttt ttagacgtaa 1501621 aacaaatgaa ttatattatg aacttgaaag aatgtaaaga acaatttatg atcaaatgaa 1501681 gatgctttct cttaagggaa gtaaatctac aaggagtgaa gaaaatggag tatcaatatc 1501741 cgatgaatga agattggaca accgaagaag cagtggatgt gattgcattt ttccagcagg 1501801 ttgagcttgc atatgaaaaa ggggcggatc gtgaagaact gcttaaagct taccgccgtt 1501861 tcaaggaaat tgtaccgggg aaggccgaag aaaaaaagct atgcggcgag tttgaggaac 1501921 aaagtacata ttctccttat cgcacggtca aacaggcgag agaatctgat cacgcgaaga 1501981 ttaagatgta agaaaaagag ccgggggata tcccggctct tttttatgct tgtgttactt 1502041 tttgggtgag acggtacaga aaagcaagct gtttaaaggc atcgtcgata cgctgaagga 1502101 attcctggtt attcatattc agcacttctt ctttttggag ctggatgccg cataacagct 1502161 cggctttctt tacagtctgc aaacgctcaa acagtgtctt cagctgttcc ttgtccattt 1502221 cagactgttt atgtactccc ggttttgtgt gatctgcaga ccaaacgaag ctgtcaggga 1502281 tatttttcgt aatggtttct tggttcactt caagcaattt gccgtattct tctttgatag 1502341 gggattcata aataatcgcg aaccatacaa agacgtggct ttcccataaa ccaatttgga 1502401 aatgcggcag ttttttatag cctcttttgc tgtttgcgaa cgccacccag ctgtcagccg 1502461 ggggattgac ggatcttctt gcgtgctttg ccacatgcgg aaacatttca tctccggtta 1502521 aagctgataa agttggggca aaatgttcgc ctagagctgt aagcttcgga cggaccgtct 1502581 cttttaatac ttccatgcgc gcgtctaagc cttctattgt aaatgtgtta aagtcttctt 1502641 cagtgaaacg catttgtgtc atgattttcc tccttcatgc taagtataca tattttatca 1502701 cagttcatac gagcttcaaa aagattgagc gcgtttgaag taaggagaaa tgtggtaata 1502761 aacgagtagg taaacacaca attttcagaa tcatgttgcg cgtaaataga acaatcatac 1502821 gatataagaa gtaatcattg ttgaatggca aaatgggatg cttttttaca aacaaatgat 1502881 ctctggaagg ggcgaaagac aatgaggcaa gttgtaaaag agggatttaa ggaagagaaa 1502941 aacaatcgtg ttgctgtctg gagactagag gttgattatg aattggcaac cctatatgaa 1503001 gcaatgcaga aagaaaatga agagcagatt gaacaaagca aaaacaaact tgagcgactt 1503061 agaaaagaat ggattcgtct taacgggtaa aaaagcgata gtgaaaacga accgcatgaa 1503121 tggttcgttt ttacgtgaga agggatattt ttcattttcc ttgctttttc attgccgtta 1503181 tcagtatcct ataaaataaa aggtctacat agaagagagg tacgaacgaa tgacaaattg 1503241 gacggaaatc gatgagattg caaagaaatg gataagagaa gcaggcgcga gaattacaca 1503301 atccatgcat gaaagcctga caattgaaac gaaatcaaat ccgaatgatt tagtcaccaa 1503361 tattgacaaa gaaaccgaaa agtttttcat tgatcgaatt caagaaacat ttccgggaca 1503421 tcggatactc ggtgaagagg ggcaaggaga caaaatccac tcacttgagg gagtcgtatg 1503481 gattattgat ccgattgatg ggacgatgaa ttttgtgcac cagcaaagaa attttgcgat 1503541 ttccattggg atttttgaaa acggtgaagg taaaatcggt ttaatttatg atgtggtgca 1503601 cgatgagttg tatcacgcat ttagcggcag aggagcttat atgaatgaaa cgaagctggc 1503661 tccattaaaa gaaaccgtca ttgaagaagc gattcttgcc attaatgcaa catgggtaac 1503721 ggaaaacaga agaattgatc aaagtgtgtt agcgccactt gtgaaaagag tcagaggcac 1503781 acgctcctac ggttctgccg ctttagagct ggcaaatgtc gcggcaggaa gaatagatgc 1503841 ttacatcacg atgcggcttg cgccatggga ctacgcagcc ggctgtgtgc tgttaaatga 1503901 agtaggaggc acctatacga ccattgaagg agagccgttt acctttttag aaaaccacag 1503961 tgtgctagcc ggaaacccat ctatacataa aacgatattt gaagagtatc ttcatgctcg 1504021 gaagtaggcc atttgagcag gatgatctca gcttgttaga aaagctcgcg gaggctcatc 1504081 ctgtatggaa agaggaggag tttggagata aagatgcaga agactatatc atttcctact 1504141 ccatgtacaa cggttcatgg cttgtatggg aaaaagacgg tatgcctgtt gccgtcagct 1504201 accatctcga gtggtctcct tcaaacggta agccgtggct cggaacggtc ctgattgacc 1504261 cggctgaaga aaaaaaggga catgcgaaga tgatcattga acagatcagc aaattgctta 1504321 gagcgaaaca taaagcgatg tttgcgggag ttcccattga gcgcagggaa tggatactgt 1504381 ttttaagcca atgcggcttt gaacagctga aaacggaaaa agatgagaaa ggcaaatcat 1504441 ttatgatctt ggtgaagcct ttagcagaag ctgccgtatg ataatggcag cttatttgct 1504501 gcatgcgggt tcaataaaaa gcctctcaaa cattgagagg cttctgatga tttgaaaatt 1504561 atttttttac cgcatgaata taatgaatcg tttcaaacgc tgacaaattg tcttttcgat 1504621 tactaaagaa aaggtcattg atgtcgtctg gtgatagatg ttcatagatc agtaaaccag 1504681 atgactctaa cagatgttca atctcttgat aagtgaaaca tgatttcatc ggttccccgc 1504741 ttgcggcagc catcttcacc atatgttcaa ctcgattcga cgtccctttt gctgtaaaaa 1504801 gtgtttcgtc cgcataatca aaaacaatag agcttccagg cgggacatga gaaaataaat 1504861 tgctgatcaa gcttgcattt tcttcccgtg ttacataata agacactccg agaaggctga 1504921 agaatgtttt tgtgttttta aatccttcat ctaagagagg atcatacgaa aacgttttgg 1504981 tgaaatccat aggaacaaaa tgaagatgac ccggaattgt cagatttgca tccttcagct 1505041 tatttttttt caattgctgt gtggccggat gatcaacctc gaaaacctgt aagctgtttt 1505101 ctaattctgg atgccgaaag cagaaagtat ccagtcccgc tccaagaatg acatactgtt 1505161 ttgcccccag gattaattcg ttgtgcaaga ctttttcaca ataagaagca cgtgctaggg 1505221 gcgttggaga cagctggatt tgtgcaaccc attttaatat tttttcagga tcattttgaa 1505281 gacgttcggc gatctctttg ttgaaaaacg atatttcttg aatcatattt ttactgatgt 1505341 cgataaactc tttttcgtta atgagatctt ttgcgataaa atcatcaaaa ataagaggtg 1505401 tgtcatatcg gctgtgatat gcacgggcaa aagctgaaat tagagacgtt aagctggact 1505461 catttttcct catgaaatga tcctccacaa aaaataagat tcccctggcc aggagaatct 1505521 tattatacat acaaatatat taatagtaaa ttttagcata aataaatttt tttgtcaatg 1505581 tttttgctct taactggacg cgcgatcctt cacatagcca cgtgacctgt agcagaattc 1505641 gtctatcaat tatgtggact gaatcattag cttttataaa atgcgcactt gcggctgcat 1505701 ccctctttat gcaaatcagg agcggttttc tgtctcatgg cagcatcttt tcgtcgtttc 1505761 agctgagaga gaaatcaaga tatgtaacaa taaaagcctg agggatctca ggcttttcct 1505821 aatattacaa tccaacagca ttccaggctg cttcaacttt agcggcatca gttgagccgt 1505881 agaggtcacg ggcagactga atgagagctg ccttggcatc tttgaacgtg gaagaaggcg 1505941 tgaggtacgt tgttaacgca cggtaataga tttgctgtga tttagataca ccaagttttg 1506001 tgatggtgtt gtaagcggct ttgtttggaa ttccgctgtt tgtgtgtaca ccgccataat 1506061 cgccttcatc tgtgtttgga aggtttcggt aattggcgta attgtcaggc tggttgtatt 1506121 ttgtagggtt ggacaggctg cgaagagcag gctggctgac cgtaatgtct tcaccgatgt 1506181 cccagtcttc tgtatcgtta aaatacccga atacgtcaga gaaagactcg tttaatgcac 1506241 ctggctgatt ttcataaatc aagttggctg tttcttgggt gacgccatgt gtcatttcat 1506301 gcgctgtcac atctaatgag ccggaaagcg gagagaagaa tgaaccgtcg ccatcaccgt 1506361 aaatcatctg gtctcctgtc catgcagcgt tattgtattg agtgccgtag tgaacggaag 1506421 aaacgatttt actgcctttg ttatcatagc tgtttcgttt aaagtttgaa taaaaataat 1506481 cgtacacttt accgaggtta tagtgtgcgt caacggctgc ccgctgtgat gaagatgtaa 1506541 atgttttcgt tgtgcttgag acaagcgtgc ccggaaggcg gctttgtctg ttttgcaaat 1506601 catatgtgat gatttgggtg cctgttggtt ttgaaagatc tcttagaaca tattttccgc 1506661 cttcataaga gatgttcaaa ggaacagttg cgccctttag cgttgttccg cttccagtgg 1506721 cggcggcatg ttctacttta ttttgctgtt ttaaaatgct gcctgtttcg gcgtcaacta 1506781 agacttccca gtttgcaggt tcaggctcga catagcgaat cgtcacgtcg taagcaagac 1506841 gatagctgcc gtcttttgtt tctatcgctt ttaattcggc tttattgctg tttttggccg 1506901 ctccgttaga aacagcgtct ggtgatttgc cgatagcttt gaaagcgagt gccagcgctt 1506961 tttcagaaga gactttttgg ctgttatctg tttttgcagc agattgattg tgtaattcac 1507021 cattgaccgc atagacatta tcggatttat cgacgtgaac gatcacttgc gaatctttaa 1507081 ttggcactcc gttaacgaca ggcgcatatc gaaagtgctt gtatccaagg gcatcagtcg 1507141 tgctttcaac aagcttcagc cttttggaag ggtcaccttt aaaaatgttg ctgttctttt 1507201 tcaaaaactg cttgacagcc ttgtcatttg gtgcagagag ttctgattgc gcaatcgcgt 1507261 ttttggagag gaaatttgtt tgattctctt taagctgatg accttcagca gcctgaacac 1507321 ctggcaggct gattgataaa ctcataaacg aagcagcgac agcaacagac aatttcttac 1507381 ctaaacccac aataaatccc cctttttgaa aatactgaaa actttatatt gttatattaa 1507441 actagcattc tggaatactc aacaaaaact aacataacta gacaaaattg atagtattgt 1507501 cctgtgtttg tttttgttga ataatatcaa gatgagtcaa gtgtcatgtg gtggttcatt 1507561 caagagttat gttttttaca tatcaagggg aagatgagat atttttgttt catcttgaaa 1507621 ctttttgaaa agtccgctgt ctaaccgaat gaggccttaa taagaagtaa aggattgttg 1507681 ttcgtgttgg agttattcag tcattatgta ttgcatttcg aacgttattt tatattaagc 1507741 agacaaagca ccctgctgat tcaatggtca attgttgttc tggcgggctt atatcttttg 1507801 gtgcatcatc ccaaaataaa ccggcagcgc acaatgttct tggcgggtgt tatattgcgg 1507861 attgtgctgc tggcgggagt gtctgttgaa cttattcacc aggtgcaatc aacaaacttc 1507921 accagcgctt acttaagaga ggacggaaaa gaactgctgc cgctgctgca ttttttgtta 1507981 tacggatatg tgctgctgac ggcttttcac tatatgctga tgccgcgtga tcatggcgga 1508041 aagggtaagt tttatacgtt cgaccttgct gttgtcagtt tgccgatcgt acaaatgatt 1508101 tttagtttct tttcgtattg gaaggaatac ccggatggga tggagccgat tgcattcgtg 1508161 tttctgtttt tcatcatcac tcttcccatt gcgttgaatg tagtgttttt caagctgtat 1508221 tggagaacgg ataagatctt actaggctta ttttatacgc tgattatcgg actgcttgtc 1508281 ttgctgcttg cgccatatcc caatcaaatc tcaaaagatt atggtgcagt aatgccatat 1508341 acgatttatt tggcaatggc gggatttttg atgagctatc atctgttcca aaagtcagga 1508401 aaggtttatg tgcgtgtgaa taagtgggtg acgatggctg tcatggtgtt ttttgtcctg 1508461 ctgttaaatc cgatatataa cataggaacg gctgctttcg ctgtatcaaa gccagcaaat 1508521 gtccatgatt cattcaattt tgtcggggag cacatttcat cagaaaaagc ggaacagata 1508581 ctaaagtcat tttttcctac ggatgaaaca ctttatttgc acgatacaaa catggatgtg 1508641 cattatttct actcatttga aagcaaaggt tacaaagctg aggtagatga agtatcgcag 1508701 ctaattcgta attatgaata cttacaaaaa gcacatggga aaaagctaac gaatcaggag 1508761 tacaagcgaa agtccatcgc tttccttgag cgacacggac gtgtgttaca taaggatcat 1508821 atcgaaacaa aggtatctca agaagacggc cagacagtcg tacgtattta cctgaaaaat 1508881 caacttcata aaaaagatca tgctgatgat ggcgcggtat tttattggga aaaggaaacc 1508941 ttaatggggt ttagtgaaga tccttcgatt tatcagcttg actctcttct gcatgttcat 1509001 ataacggaac aagacattca cgacaaagtg gaacaaatgt ttacagcgct gaacatatca 1509061 aaacagcctt atcagatcac tgatattgaa agcgacagcc tgcttggaag catggtgaga 1509121 gttgaaacaa aagttggaat tgttttggaa tttgagggcg aatcaggttg tttacatagt 1509181 ctttcgcttc cgatgaaaaa gaatatctca atggctaaca gccggctgca gcatcagata 1509241 ttatcgatct tcgatgctcg tggatcagaa aagaagaaaa aaagcagtca gggtgacatg 1509301 gtgatgtata ctgattcttc taaaacatat gagtttgttg aagctcaagg tcagctaaac 1509361 gtttatgtat acagcgatac acctgatcag tcattcccct atacgtatcg taatggaaca 1509421 ttggcttacg aaaaagtagc ttctctatat caggatgtca tttacaaaaa gcgtatgcgt 1509481 ccgattatcg ttcaaagagg ggatgaacgg cattatgcat ggctgatcat tattcagccg 1509541 tttggttcaa atcgccatga tgcctatgta gtggatggag aaacacaaga ggtgaaaagt 1509601 ctttatgaat cataaagaaa aagagtctgt ttttgtagac ttatacgacc tgtataaaga 1509661 aggagagcta gaggatgaat caatggaatg gatgaaacag catgaatccc tatttcaaaa 1509721 gaatgcggaa gacttaaaga gtaaaacttg tttaaagaga agtcccggtg ctgaagaaga 1509781 aagccaaatc agatatatga aagtatacct gtcttccatg tatatctgtt tcattttatt 1509841 ggccatttgg atgacggtgt ggttttattt ttaatgaagc atagggattc cattgaggac 1509901 ttgtatcggc agtattatca agaaatttta aattatttat tcagaaggac tcatcatctt 1509961 gaaacagcca aggacttagc gcaggacacg tttgtaaaag ctcttaacgg tctggcttcg 1510021 tttagggggc attcttccat cagaacatgg ctctacacca ttgcgcatca tacctttatc 1510081 aattggtacc gaagggatgt caaataccaa tttactgaaa tcagcaaaaa tgaagggtta 1510141 acgcaaacaa cttatgacca gcctgaacag tatctgtcac ggacggtgaa aagcgaaaca 1510201 ctgcggcagg agctcctgaa gttaaaagat cagcatcaat ccgttttgat tttaagagaa 1510261 ttccaagagc tttcttatga agaaatcgct gagatattag gatggagtct ttctaaggtg 1510321 aataccacat tgcaccgggc tagattagag ctaaagaaaa acatgacgaa aagtagagag 1510381 gaggagcgga tatgacctgc tttctagtaa gagacctgct tcctctgtat cttgaaggtg 1510441 attgtaaaag agaaacggaa cacgttatag aagagcattt aaaaatgtgc agcagctgca 1510501 gagacatgta tgacacgatg gctgagccat ttgaattgga aagcgaacag gccgttgagg 1510561 aggcttatct gccggaagaa gaactgcgtt ttaaacagag gtactatgga ttactgatca 1510621 tgaaagctgc ctgctggttt ggagcggcgg ttgccatgat gctgatcatc aaactgctga 1510681 tataaaaaaa gcgcttgtcc gattccggca agcgcttttt tacattaagc ctggggatga 1510741 atcatatcgt aaatagcggc aagctgttct tgtgacaggg cactgaagag tttttcataa 1510801 acgtcagctt gcagtggcgt tgcacctgct tgtagcgctg cgtctttatc atagctgtac 1510861 acatcatctt gtagcacaat ggctgcttga agaatgtgaa tcttgagaga aacagcggag 1510921 aaaaattgtt caagtgcaag tgcttctttt tctgtgaagc caagttcaac tgctttttct 1510981 gtatcaaatt tgtaatttcc atcctcgaga tacacacatt gtgaaacaat gctgaaaaat 1511041 tctgatgtcg attcccagag tgtagcaatt acctgagcct cttcttttgt cattcctaac 1511101 tcgacagctt tttcgctgtc aaaataatat acaccgtctt gttcgtatat acattgattt 1511161 aatatatcaa tgaatgtatt gagatcttcg ttagtgctcg cctgatgctg gagttgaaca 1511221 gcagtgttat caaccggtgt ttttgcgctg gctgcatcag gaccgaacgt taatagagca 1511281 gctgaggtca ttgcggcagt cgttaacata gcttttttta caaatgtttt cttcatgttt 1511341 cttctctccc ttttatgaat tgtgctacaa attccattat agggagtagt ttccggtgga 1511401 ggaataggcg ctatggtatt ttatgtgtat cgttgccgaa ctactttttg aaggctgcac 1511461 gtgtgatcgt tagaacgatt gtctatgtat gaaggctgtt ttgcatcttc ctgactaaga 1511521 aacaggggag ataaggctta aagaaatgaa aaacaccgct ttctttgcgg tgttttttga 1511581 ttacaatgtc gccggcgggg caatgctttt aatcaagcaa gccttgttcg cgcattttct 1511641 tttttaatgt aaatccgccg cccatgacag cgcaaacaag tacaatgctg gcgataatgc 1511701 ctgcagggct tttttcagcg ataaagacgc cgatcagcat aatgctgaaa accgctgcaa 1511761 atgcaaataa tagtaaaagc caattcattt ttttcataaa ttccatcccc ttttacgtct 1511821 tatattaagt ttacagaaaa acgtgacgct tttaaagagg atgtgtgata taatatgaaa 1511881 gttatctaat ttttttagga gatgaaaaag tgaaacttcg aaatgatctt cgcaacatcg 1511941 cgattattgc ccacgttgac catgggaaaa cgactctagt cgatcagctt ttacatcagg 1512001 ctggtacgtt ccgtgccaac gaacaggttg ctgaacgcgc aatggactct aatgatcttg 1512061 aacgcgaacg cggcattaca atattggcga aaaatactgc gattaactat aaagatacac 1512121 gtatcaatat tttggacacc cctggacatg cagactttgg gggagaagta gaacggatta 1512181 tgaaaatggt tgacggcgta gtgcttgtcg ttgacgcata tgaaggctgt atgcctcaaa 1512241 ctcgttttgt tctgaaaaaa gctcttgagc aaaacctgaa ccctgttgtt gttgtaaaca 1512301 aaattgaccg tgactttgct cgtccagagg aagttatcga tgaagttctg gatctgttca 1512361 ttgagcttga tgccaatgaa gagcagctcg agttcccagt ggtatatgct tccgcgatta 1512421 atggaacagc gagtcttgat ccgaaacaac aggatgaaaa catggaagct ttatatgaaa 1512481 ccattattaa gcatgttccg gcacctgttg ataatgcaga ggagccgctt caattccaag 1512541 ttgcccttct tgactacaac gactatgtag gccgtatcgg aatcggacgc gtattccgcg 1512601 gcacaatgaa agtcggacag caggtttctc ttatgaagct tgacggaacg gcaaagtcat 1512661 tccgtgttac aaagattttt ggtttccaag gcttaaagcg tgtggaaatt gaagaagcaa 1512721 aagcgggaga cctcgttgcg gtttccggga tggaagatat caacgttggt gaaacggtat 1512781 gtcctgtaga ccatcaagat ccgcttccgg tccttcgcat tgatgagccg acacttcaaa 1512841 tgacatttgt cgtgaataac agtccgtttg caggccgtga aggcaaatat gtaacggccc 1512901 gcaaaatcga agagcgtctt caatcacagc ttcagacgga tgtgagcttg cgtgttgagc 1512961 caacagcttc tcctgatgct tgggttgttt caggacgcgg tgagctgcac ttgtcaattt 1513021 taattgaaaa tatgcgtcgt gagggctatg agcttcaagt gtcaaaacct gaagttatta 1513081 tcaaagaaat cgacggcgta cgctgtgagc ctgttgaacg tgtgcaaatt gatgttcctg 1513141 aagagcatac tggctctgta atggaatcaa tgggtgcccg caaaggcgaa atggttgata 1513201 tgatcaacaa cggaaacggc caagtccgtc tcatctttac agttccttcc cgcggattga 1513261 tcggttactc tacagaattc ctatcattaa cacgcggatt cggtattttg aaccatacgt 1513321 ttgacagcta ccagccgatg caggcaggcc aagtcggcgg acgccgtcaa ggtgtacttg 1513381 tgtcaatgga aaacggaaaa gcaacatcat acggtattca aggaattgaa gaccgcggtg 1513441 tcatcttcgt tgagccgggt actgaagtat acgaaggaat gatcgttgga gagcataacc 1513501 gtgacaacga ccttgttgtt aacgtcagca aaatgaaaca gcaaacaaac gtccgttctg 1513561 cgacaaagga tcagacaact acaattaaaa aagcgcgcat catgtctctt gaggagtctc 1513621 tagagtactt aaacgaagat gaatattgtg aagtaacacc tgaatccatc cgtttaagaa 1513681 agaagatcct caataagaac gaacgtgaaa aagcagctaa aaagaaaaaa acagcaggat 1513741 tgtcttaatc tcgtgcagaa tttgaaaaga tagaacccgt acgtttacag gggagggaat 1513801 ctttttgaat gacgtaagcg aacgcctgtc gttcttcgcc gctctatatc aagtagaccg 1513861 gcagcctgcg gcaggcatgt ggctgctgta cggcacgatt tttgtgttgg ccgttattgt 1513921 atttaagctt ggatttgcta aacggcttcc tgtattaaaa tctgcagtgg tgtatgtatt 1513981 tttggctttg ggctgcactg ttttgacttt tttaggggtg tttttgcccg tggcagaagg 1514041 attggtcgtc gctgcgctga ttttaatcat ttacaaaatc cggctgtatc agtcgaaaaa 1514101 aggacagtct gcaaaatcat aaaagactca gctgaaagct gagtcttttt tgtgttctgt 1514161 atggttaagc ggccgcttta ttttttgact ttttcttttt tctgctgtcc cgggtgaaaa 1514221 gtaaattttc ccgttttcag ccgttcctct gtttttttgg caatccgatc gtggcattcc 1514281 tggcacatat atgtatggat cgggcggttt cgaagccgtt tcgcgatcag ggtatcatca 1514341 tcaattgttt caattttatc gcaaatagaa catttgaccc tcatcatatc acctctttca 1514401 ctaacatgta ttataccacg gatcagaagc tgtccaaaat aagaaaaagc taaagcgcaa 1514461 ggctatagct tagtcattgt tgttcttttt catatgatga tcagattgat cgttttgttc 1514521 cttctccatt tcctgttgct gttttctatt taattggtca ttttgctgct ttgtttgcgg 1514581 ttcatcttca ttgtcaatca catcgttagg cacttcggga agcactcggc cgacaattgc 1514641 agctaattca tccagtatac ctgttaccgg atggccctcg ctgatttctc tgctcatttc 1514701 gcgaaggcgg ctgaccgtat cgggatcagc aatgactact gcgttggcgc catatcgatc 1514761 attctttagc gcctgagcta cagaatattt aatggtttcc actttgcttc tgtccaaagt 1514821 atcatcgaca tcaatcccaa caacagcata gcctcccagc acaacggctg ttgcatcctt 1514881 gacgtcgggg tttttttcag caacgctgac aagatgcttg gcaatatccg ttcttgttcc 1514941 attgtctttt gtttcttgag ttgtgtcctt tacgtgaatc ggtttagtct cctgctgtct 1515001 tgttgattct ttttcaacat tctggccctg ttttccttgt tgataggcac aagcggacag 1515061 gataagtgtc agctgtatga taatgaaaag aattcgcact tgcgggttcc ctccttaaaa 1515121 tgctttcatt aattttattg ttgaattaac cttctatctt tatgcacaaa aacatatatt 1515181 ttagcaggca ttcacctttt tcatcaaaag agaagcagga agaactttga cccttatatc 1515241 aggaggctga gacttgagta aaatttatgt gttagatacg aatgtgttat tacaggatcc 1515301 taacgcgata ttttcttttg aagaaaatga ggttgtcatc cctgctgtcg ttttagaaga 1515361 ggttgattca aaaaaacggt atatggacga agttgggagg aatgcaaggc acgtatctaa 1515421 gctaatcgat gcgctaagac aaaagggcag gctgcatgag catgtaccgc ttgacaccgg 1515481 cggcacactg agaattgaac tgaatcatcg ttcgtttcac cagctgcaag agatctttat 1515541 tgaaaagacg aacgataatc gcatattagc cgttgcgaaa aacttaagcc tcgaggaaga 1515601 aaccaaggaa aatggcaggc cggttatcct tgtcagtaag gatgtactgg tcagggttaa 1515661 agccgacgca atcggactgc ttgctgaaga tttcttgaat gaccgggttg tggacaatga 1515721 tgaaatgtac agcggctata aagatttata tatcagccag cagctgttca gctcttttta 1515781 cgggaaaaat caaatttcag taaacgatgt gaaacagcat gcgttttatc cgaatcagtt 1515841 tgctttaatg aaggatgagc taggagggtc ctcctcggca gtcggaattg cagacaaaac 1515901 cggaacggta ttaaaaagac tcgtatttga tgatgaacat atatggggaa tcaggccgaa 1515961 aaatgtacag cagacaatgg cattagagct tttgctgcgg gaagatattc cgcttgtcac 1516021 cctgatcggc aaagcgggaa ccggcaaaac gctcttagct ttggcggcag ggctattaca 1516081 gacagaagac ttgggaatat ataaaaagct ggtcgtcgca aggccgattg ttcctgttgg 1516141 caaggacatc gggtatttgc caggcgaaaa agaggaaaag ctaaagcctt ggatgcagcc 1516201 gatttttgac aacttagagt ttctgtttaa tgcgaaaaaa ccaggggagc ttgatgctat 1516261 tttggcggga attggctcaa ttcaggtaga ggcgctgact tatatcagag ggagaagcat 1516321 tccagatcaa tttattatca ttgatgaagc gcaaaatttg accaggcatg aggtgaaaac 1516381 gttgctgacg agagtcggtg agggcagtaa aattgtctta atgggcgacc ctgaacaaat 1516441 tgatcaccca tatttagaca gtctgaacaa tggtttggcc tatgtggttg agcggtttaa 1516501 aggacaaccc atctcaggca gcgtgaagct gttaaaaggt gagagatcag gtctcgccca 1516561 gcttgcagct gatttgctgt aacacttaaa tgatttcgat ctcttttaca tcggtaatcg 1516621 gctgtttgtg atgaaccggg tcttcaaagt aaatatgcac ggggccgcct tcttgaatcg 1516681 gcttgcctgc ctcactgaaa tggacaatac tgttcagagc ggtttccaga gaaacggcgg 1516741 cctttcccga acttgtgaca aatacacatt gtgtcgcaga gctgttcggc tcagcatttt 1516801 tcaggacagt cccaagtctc attgcgaaac tgccgttcat cagtttttgc ttctcatatt 1516861 gcttttccgt ctttaatgta ggcggcgcga ttcgcccctc tctgatgacg cgttccggat 1516921 caaggtcgga ttcatccccg gctgattgta aatatgtgtc ttgactgtcc cctttgcggt 1516981 caaacgaaaa tttgcgatca tcaaaaatcc atacgcttgg atcaatggta attggatatg 1517041 taacattgcc ttttacttgg ataacgctca tgatatgacc cccttctctc aaaattataa 1517101 aagttttcgc atgaattgtc actttgtgta caaattatgt gtattgaaat gctgagggaa 1517161 cgagggtgtt tgcatggtat gccagcataa tgatgagctt gaagccttag tgaaaaaggc 1517221 gaaaaaagta acggacaagg gggaggtagc cagctatatt cccgccttgg caaaagctga 1517281 taaacacgac ctgtcagtgg cgatttatta ttccaataat gtttgtctgt cagcaggtga 1517341 cgtagaaaaa acatttacgc ttcaaagtat atcgaaagtc ctttcccttg ctttggtgtt 1517401 aatggaatac ggcaaagata aggtcttcag ttatgttgga caggagccga ccggtgatcc 1517461 gtttaattca attatcaagc tcgaaacagt gaatccgagc aagccgttaa accctatgat 1517521 taatgccggg gcattggtag tgacaagtct gataagggga agaacggtaa aagagagact 1517581 tgattatttg ctttctttta tcagaaggct gacaaacaac caagagatta catactgccg 1517641 ggaagtggct gaatctgaat acagcacttc aatgattaat cgggcgatgt gttattatat 1517701 gaagcagtac ggcatttttg aagatgatgt agaggcagta atggatttat atacgaagca 1517761 atgcgcgatt gagatgaaca gcttggattt agcgaaaatc ggatctgtat tcgcattgaa 1517821 cggcagacat ccagagactg gggagcaggt catctcaaaa gatgtcgcta gaatttgcaa 1517881 aacgtttatg gtgacgtgcg gaatgtacaa tgcaagcggg gaattcgcaa ttaaggtcgg 1517941 aattcctgcg aaaagcggcg tatccggcgg gataatgggc atttcgcctt acgatttcgg 1518001 gatcggcata ttcggccccg cattagacga aaaagggaac agcattgcag gtgtaaagct 1518061 tttggaaata atgtctgaga tgtacaggct gagtattttt taatttatgt catatgctta 1518121 aatcctcttg cattttctgt tgataccctt tatgataaat agaagaatta ggtactcgcc 1518181 tggggaacgg agggatactt ttggcttcag agatgatagt tgaccatcgg caaaaagctt 1518241 ttgaactctt aaaagtggac gctgagaaga ttttgaagct gatccgagta caaatggata 1518301 acttaacgat gcctcaatgt cctctatatg aagaggtttt agatactcaa atgttcgggc 1518361 tttcgaggga aatcgatttt gctgtccgcc tgggattggt tgatgaaaaa gacggtaaag 1518421 accttttata cacattggag cgcgaattgt ctgctttgca tgacgcgttt acagctaaat 1518481 aaatgataaa actcaaactt attaacagtt tgggtttttt tataaccgct atttttctct 1518541 catctcataa aagacggtct ttttttacac attccttccg aatcgtatag agattcttcg 1518601 tctcgtttga taaattgtag taaaataaaa aagataaata cataaaaacc atagataatg 1518661 gaagttagaa gcagggaaga ggatgttatg ttaaaaaaaa tgctaaaatc ttatgattac 1518721 tcactgatat tcgcaatcgt tttattatgc ggattcggtt tagtgatggt atacagctca 1518781 agcatgatta cggctgtctc ccggtatgga gtaagcagta attttttctt catgcggcag 1518841 ctgtttgctt taattgcggg tggcgctcta tttattctca tggcgttgtt tccttataaa 1518901 gcactggccc atcaaaagtt tcagaagggg atactgcttg tatctgttct tgcgcttatc 1518961 tcactgtttg ttttcgggca tgttgccgga aacgcgcaga gctggtttaa aatcggcgga 1519021 atgagtattc agccggggga gtttgtgaaa ctggtcgtga ttttatacct tgcagccgta 1519081 tatgcaaaaa aacaaagtta tatcgaccat ctgttaacgg gagtagcccc tccggtagtc 1519141 atgacgctta taatttgtgg gttaattgcc atgcagccag atttcggtac agccatgatt 1519201 atagggttaa ttgcgacgtg catgatcttg tgctccggct tcagcggaaa gacgctggtg 1519261 aggcttgtga tactgggcgg aattgttttc attttagtca gccctattat ctatttgaat 1519321 caggacaaaa ttttaactga aggccgttta gcgcgttttg agagtcttga agacccattt 1519381 aagtatgcaa attcatcagg tttgcaagtg atcaattctt attatgcgat cagctcaggc 1519441 ggcattttcg gcctggggct cggtgaaagt atccaaaaat acggatatct gcctgaatca 1519501 cacactgact ttattatggc tgtcattgct gaagagctcg gcatttttgg ggtattgttt 1519561 gtgattttct tattgggttt tgtcgtcata aaaggttttt atattgccag aaaatgcgag 1519621 gacccgtttg gaagtcttct ggcgatcggc atttcaagca tgattgccat ccagtcgttt 1519681 attaaccttg gcggtgtcag cggattaatt ccgattacag gggttacgct gccatttatc 1519741 agttacgggg gctcttcttt ggtgctgctg ctggggagta tggggatatt agcgaatatc 1519801 agcatgtttg tgaaatattc agagaataag aaaaagaaag agcccttggc gccgaaggga 1519861 atgaaaaaga aacagctcaa aaaaactgtt tatctgtaaa aaacaagtgt gtacagggga 1519921 aggatattcc gctatgatag attatattcc attcgggtaa gggggagaaa agtttgtctc 1519981 agcaatcgat acaaaaagta ttagtagcaa acaggggaga aattgcaatc cgaatattcc 1520041 gggcgtgtac cgagttgaat attcgtacag ttgcggtcta ttcaaaagaa gattccggtt 1520101 cctaccatcg gtacaaagcg gatgaagcat acttggtcgg tgaagggaaa aaaccgattg 1520161 atgcttacct ggatattgaa ggtatcattg atattgcgaa aagaaacaaa gtcgatgcaa 1520221 ttcatccggg atacggtttc ttatctgaaa atattcattt tgcgagacga tgtgaagaag 1520281 aaggcatcgt attcataggg ccaaaatccg agcatctcga tatgtttggt gacaaggtaa 1520341 aagcgcgtga gcaggcagaa aaagcgggaa tccccgtgat tccgggaagc gacggtcctg 1520401 ccgaaacgct tgaagccgtc gaacaatttg gacaagctaa cggttatccg atcatcatta 1520461 aagcctcgct tggcggcggc ggccgcggta tgcggattgt cagatctgaa agtgaagtta 1520521 aagaagcata tgagcgtgct aaatcagagg cgaaagcagc ctttggcaat gatgaagttt 1520581 atgtagaaaa attaattgag aatccgaaac atattgaggt tcaggtcatt ggagacaagc 1520641 agggcaatgt cgtccatctt tttgagaggg attgctccgt tcaaagacgc catcaaaaag 1520701 tcattgaagt ggcgccgagt gtctcgctgt cacctgaatt aagggaccaa atttgtgagg 1520761 ctgcagttgc gcttgccaaa aatgtaaact atataaatgc ggggacggtc gaattccttg 1520821 ttgcaaacaa cgagttctac tttattgaag taaatcctcg cgtacaagtt gaacacacga 1520881 taacagaaat gattactggt gtcgatattg ttcaaactca gatccttgtt gcccaagggc 1520941 acagccttca cagcaaaaaa gtaaatattc ctgagcaaaa ggacattttt acaatcggct 1521001 atgccattca gtcacgggtt acgactgagg atccgcaaaa tgatttcatg cctgatacag 1521061 gaaaaatcat ggcttaccgc tcaggcggcg gttttggtgt ccgtcttgat accggaaaca 1521121 gcttccaggg cgccgtgatc acaccatact atgattcact tctcgttaag ctttcaactt 1521181 gggctttaac gtttgaacag gcagctgcca aaatggtgcg aaaccttcag gagtttagaa 1521241 tcagaggcat aaaaacgaac attccgttcc ttgagaacgt tgcaaagcat gagaagttcc 1521301 tgacagggca atatgataca tctttcattg atacaacgcc tgaattattt aatttcccta 1521361 aacaaaaaga ccgcggaacg aaaatgctca cttacatcgg caatgtgaca gtgaacggct 1521421 tccctggaat cgggaaaaaa gaaaaaccgg cgtttgacaa accgttaggc gtaaaggtag 1521481 acgttgatca gcagcctgcc agaggaacaa agcaaattct cgatgaaaaa ggtgcagaag 1521541 ggcttgcaaa ttgggttaag gagcagaaat ctgtcctttt aactgatacg acattcaggg 1521601 atgcccacca atcgttattg gcaactagaa tcagatcgca tgatttgaaa aaaatcgcaa 1521661 atccgacggc tgcgttatgg cctgaactat tcagtatgga aatgtgggga ggcgcgacct 1521721 tcgatgtagc ctaccgattc ctgaaagaag atccgtggaa acgtttggaa gatcttcgca 1521781 aagaagtgcc gaatacctta ttccagatgt tgcttcgctc atcaaatgcg gtcggctata 1521841 cgaattatcc ggacaatgtg attaaagaat ttgtgaagca atcagctcaa tccggtattg 1521901 atgtgtttcg tattttcgac agcttaaact gggtaaaagg gatgacgtta gccattgatg 1521961 ctgttaggga taccggcaaa gtggcagaag ctgcgatttg ttatacggga gatatccttg 1522021 acaagaaccg gacgaagtac gaccttgcat attatacatc gatggcgaag gagcttgagg 1522081 cggccggagc ccatattctc gggattaaag atatggcagg gctgttaaaa ccgcaggctg 1522141 catatgagct cgtttctgcg ttgaaagaaa cgatcgacat tccggttcac cttcatacgc 1522201 atgatacgag cggaaacggt atttatatgt atgcgaaagc tgttgaagcc ggcgttgata 1522261 tcatagacgt ggcggtcagc tcaatggcgg gattaacgtc acagcctagc gcgagcggat 1522321 tttatcatgc gatggaaggc aacgaccgcc gtccggaaat gaatgtccaa ggcgttgaat 1522381 tgctgtccca atattgggag tcggtgcgta aatattatag tgaatttgaa agcggaatga 1522441 agtctccgca tactgaaatt tatgaacacg aaatgccagg gggccaatac agcaacctgc 1522501 agcagcaagc caagggagta ggccttggcg accgctggaa cgaagtcaag gaaatgtaca 1522561 gacgcgtgaa cgatatgttc ggtgacatcg tcaaggtaac gccttcctca aaagtagtcg 1522621 gagatatggc actctacatg gtgcaaaaca atctgactga aaaagacgtt tacgaaaaag 1522681 gtgaatcttt agatttccct gattctgtcg tggagctttt taaaggaaat atcggccagc 1522741 ctcatggcgg attcccagaa aaactgcaaa agctgatctt aaaagggcag gagccgatta 1522801 cagtcagacc gggcgaactg cttgagccgg tgtcatttga agcgatcaaa caggaattta 1522861 aagagcagca taacttggaa atttcagatc aggatgctgt ggcatatgcc ctttatccta 1522921 aagtcttcac tgattatgtg aaaacgacag aaagctatgg agacatctcg gtattagata 1522981 caccgacatt cttctacggt atgacattag gtgaagagat agaagttgaa attgagcgcg 1523041 gcaaaacgct gatcgttaag ctgatttcaa tcggtgagcc tcagcctgat gccacccgcg 1523101 tcgtttattt cgaactcaac gggcagccgc gtgaagtagt cattaaagat gaaagcatta 1523161 agtcttccgt tcaggaaagg ctgaaagcag accggacaaa tccaagccac atcgcagctt 1523221 ccatgcctgg aacagttatt aaggtattgg ctgaagcagg cacaaaagtc aataaaggtg 1523281 atcatttgat gattaatgaa gcgatgaaaa tggaaacaac ggttcaggcg cctttctcag 1523341 gaacaatcaa gcaggttcat gtgaaaaatg gtgagccgat ccaaacggga gatctgctcc 1523401 ttgaaattga aaaagcataa aaaacaaaga gtgtatatca atgatataca ctcttgtttt 1523461 ttatatagaa aatgtggagt gaaacagatg gttagaagag atataagggg acttcagaga 1523521 ttatagagta ctgtcacaag cccaaaataa aaagaggctt atacagccaa tattttagat 1523581 gctttgtagt atgccgtgca tatttcttta agcactatct gatttaaaag gctttaatac 1523641 ttatgttcgc gagctataga tccatatgaa atttctataa tcacgatgag aaaggggaca 1523701 gaccgaagtg agccgctcac tgatcatcaa gttcggcgaa ggctggcgat tgaaacgcat 1523761 aaagcgccaa aaaacaagac ataaaaaaga ccaaagccgc ctaaggcttt ggtcttgagt 1523821 ccttatgatt gcctggattc ataacggaaa cgagcaatca ataataagaa gtagcataga 1523881 acgccaaaca gacaggcaat aaagaacgag tgggcaagtg caaagcccag agccagttca 1523941 gagtatacga tcataatacc ggacagtgcc tgtaatgtaa tgaaaataag acatgagatc 1524001 catccccaaa agatctgttt ttgatcttta taggaagtaa tagcatgaac agcggcaaca 1524061 ataatccata caaataaaag taaggctgct gctctgtggc ccatttgcac ccattcatgg 1524121 aattgggtcg gaagtccatt gttcagcggg ctgcacagcg gcacattagg acatgccaga 1524181 cttgattcag tgtgtcttac atatgcgcct gtatacacaa cgatatagga atatattaaa 1524241 attcctatca tgtgaaattg catctttttg ccgatttgaa gcggcttaac cagtgttctg 1524301 actgatttat cagcttcaaa tatgagcaat gttaaaataa gcactgaagc aaaagaaatt 1524361 aatgagatgc cgaagtgaag cgccataatc agcgcgttcg aaccgaatac gacagccaat 1524421 gcgccaagca atgcctgaag aaataaaaag ataattgaca tgatcgcgag aaacgttgtt 1524481 tcacgaaaaa tcggcgtgat ttttctccat gaccaaaacg caaggcttag cacaaggata 1524541 atagagattc cgcttgcgaa tcggtggctc cattcaataa ttgaagccgg attcagttca 1524601 gggaaaaaac ggccgtgaca cagcggccac tgtctgccgc atccttggcc ggaacctgtt 1524661 tttgtaacga gggcaccccc gattaaaaca attagcatga caaatgtcgt cagaacaccg 1524721 agagctttta atgctttatt catacaatat tcaccttctt aacatactgc tgcaatttta 1524781 tatacgttcc aagtgtaagc gaatatgtgt tttgtggcaa ttcccagagc cttttgttca 1524841 caaaaatata atagaatgac ggcttctgga aaatgtacac ttgattattc atgccgggtc 1524901 tgatagaaat aaggtaaacg caatgccgat ttggagattg ccttcatctt tggtaaaatt 1524961 cataaaaagt tcacaaataa attcctgttt gtcgtttaat atttaatagg atgttttttt 1525021 acaagatgtt atcttgtatg atagagttgc aggttatttt attctcctgc gttaggtttg 1525081 taagggaggt ttacgttatg gctaactcca gaatcttaaa tgatacagct atagacggac 1525141 aaattgaaga aacaacggca tggaaagatt ttctgtccct tattaaaata gggatcgtca 1525201 attctaacct catcacgact ttcactggaa tgtggcttgc actgcatata tccggtttaa 1525261 gttttttagg caatataaac accgttcttc ttacgttaat cgggtcttca ctgattattg 1525321 cgggctcctg cgcgatcaat aactggtatg accgggacat tgaccatctt atggagcgta 1525381 cgaaagtaag accgacggtt acgggtaaaa ttcagccgag tcaggcgtta tggtctggaa 1525441 ttttgctggt tgctttagga ttgatcatgc tgctgatgac aactgtcatg gctgctgtta 1525501 tcggttttat cggagtcttt acgtatgttg tattgtacac aatgtggacg aaacgccgct 1525561 atacgattaa cacagtagta ggaagcgttt ccggtgcagt gccgccgctt attggatgga 1525621 cggcagtgga agggaatatc ggtgtcgtag catgggtgtt attcatgatt ttatttattt 1525681 ggcagattcc tcacttctta gcattggcta ttaagaaaac tgaggattac agagctgcaa 1525741 atattccgat gcttcctgtc gtatacggat ttgaagtgac aaaaagacaa attattgtgt 1525801 gggttgcgtg cctgatgccg cttccgtttt tccttggtag cctgggtctt ccgattgtca 1525861 ttctcggctt gctgttaaat atcggctggc tgattcttgg cttaatggga ttccgctcca 1525921 agaatatcat gaagtgggca acgcagatgt tcgtttactc gcttaactac atgacaatct 1525981 atttcgttgc catggttgtc ttgacgcttt tctaaaaaat agatatgatg cttgttttat 1526041 cgcttcaaaa taaacgatga caactagtaa atgccgcctt gacctcttgt ttaatcaggc 1526101 ggctttactt ttatacatag atggcatttt gagtaaaaaa actcataatt taagagaaga 1526161 ggaaatgtaa gtgctttatt ggtgataggt tggatggcga tagatttcga tccgctttcc 1526221 gcctttgtat tgaccagaaa aggggttggg tgaaatggta aagcattggc gtcttatttt 1526281 attattagcc ttagtgccgc ttctattaag cggatgtgga aaaccttttt tatccacgct 1526341 caagcctgct ggcgaggtgg ctgataaaca gtatgacctg acagtgctca gcacattgat 1526401 tatggtggtt gttgttgcag tagtatctgt tatcttcttt tatgtgattg tgagattcag 1526461 aagatcacgg gtcggtgaga acacgatacc gaaacaggta gaggggaata aatttttaga 1526521 aatcacatgg accgtgatcc cgattttgct gctcattatt cttgtgattc ctgttgtatt 1526581 atatacgctg gagctagcgg acacatcacc aatggataaa aaaggccgca aagctgagga 1526641 tgctcttgta gtcaatgtta gggcaaattt atactggtgg gagtttgagt accctgatta 1526701 cggcattatc acaagccagg agctgattgt accgacagat cagcgtgtat attttaattt 1526761 aaaagcctct gatgtaaaac attccttctg gattccttca gttggaggaa aacttgatac 1526821 gaatacggat aatgaaaata agttcttcct gacatttgat tcaaaacgaa gcaaagaggc 1526881 aggagatatg ttttttggga agtgtgcaga gctttgcggc ccttcacatg cgctgatgga 1526941 ttttaaggtg aagacgatgt ctgcaaaaga atttcagggc tggacaaaag aaatgaagaa 1527001 ctataagtct acagcagaga gcgatttggc taagcagggt gaagaactgt ttaaagagaa 1527061 aaactgcctg agctgccatg cggtagagcc gaatgataag cgtgcagaag ccgctagaac 1527121 ggcacctaac ttggcgacct tcggtgaaag gacaaaagtg gcaggggtga aagaggccaa 1527181 caaagaaaat gtgaaggctt ggctgaagga ccctgacagc ataaagccgg ggaacaaaat 1527241 gacaggcaca tatccaaagc tctcagacag cgaaacaaat gcgctttatg aatacttaaa 1527301 aggcttaaaa gcggaaagca agtagggaag aaagggagat attgggggag gtcacatatg 1527361 ttgaatgcgc ttacagaaaa gcggacgcgc ggatctatgc tttgggatta tttgacgacg 1527421 gtggaccata aaaaaatcgc aattctttat ttagtggcag ggggattctt ctttcttgtc 1527481 gggggaattg aagcgatgtt tatcagaatt cagcttgcaa agccggaaaa tgcgtttctc 1527541 agtgctcaag cgtacaatga agtaatgact atgcacggaa cgacgatgat ctttctggct 1527601 gcgatgccgc tcttatttgc cttgatgaat gcggttgtgc ctttgcagat cggggctcgg 1527661 gacgtttcgt ttccattttt aaacgcgctt ggtttttggc tcttcttttt cgggggcatt 1527721 ttcttaaatc taagctggtt tttgggcgga gcgccagatg cgggctggac atcatatgcc 1527781 tcactttcgc ttcattctaa agggcacggc atagactttt tcgtcctcgg actccaaata 1527841 tcggggctcg ggacgctgat agccgggatt aactttttgg ccacgattat caacatgagg 1527901 gctccgggca tgacgtatat gaggctgcct ttgtttacat ggacgacatt tgtggcctcg 1527961 gcattgattt tgttcgcgtt tccgccgctt acggttggat tggctctcat gatgctggat 1528021 cggctgttcg gaaccaattt ctttaatccg gagcttggcg gaaatacggt catttgggaa 1528081 catttatttt ggatcttcgg ccacccggag gtttatatcc taattttgcc tgcattcggt 1528141 attttttctg aggtcatccc tgtgttcgcc agaaagcgtt tgtttggcta ttcttcaatg 1528201 gtttttgcaa tcgtgctcat tggctttctg ggctttatgg tttgggtgca ccacatgttc 1528261 acgactggtc tcggcccgat tgcaaatgcg atttttgcgg ttgcaacaat ggctatcgcg 1528321 attccgaccg ggattaagat ttttaactgg ctgttgacga tttggggagg aaatgtgaag 1528381 tatacaaccg ctatgctgta tgctgtctca tttattccat cctttgtgct cggcggtgtg 1528441 acgggagtca tgctggcagc tgctgcggct gattatcagt ttcatgatac gtattttgtg 1528501 gttgcgcact tccactacgt cattattggc ggcgttgtat tcggcctttt agccggtgtt 1528561 catttctggt ggccgaaaat gttcggtaaa attctgcatg aaacgatggg gaaaatttca 1528621 tttgtattgt tttttatcgg ctttcacctc acgtttttca ttcagcattt tgtcggctta 1528681 atggggatgc cgcgccgggt ttatacgttt ttgccaggac agggtctgga aaccggcaac 1528741 ttgatcagta caatcggggc gttttttatg gcggcagctg ttattcttct gctggtcaat 1528801 gtcatatgga catcggtaaa aggtgaatat gtaggtgctg atccatggca tgacggacgt 1528861 acgctggaat ggaccgtttc ttcaccgccg ccggagtata actttaaaca gcttcctttt 1528921 gtcagaggac ttgatccgct ttggatcgag aagcaggcag ggcacaaatc aatgacgccg 1528981 gcggaaccgg ttgatgatat tcatatgcca aacggctcaa tcctgccgct catcatttcc 1529041 ttcggccttt ttgtcgcagc gttcgggctg ctgtacagaa gtgattacgc ttggggcctg 1529101 ccggtgatct ttatcgggct cggcatcaca tttattacga tgctgcttcg ttcagtaatt 1529161 gatgatcacg gctatcatat tcataaagag gaactgccga acgatgataa aggggtgaag 1529221 gcataatgca agttcaagaa aaattcaccg cagaaacctt tccagcttct cctgaaaaag 1529281 taaccctgga agggaaaaat aaatttttag gcttttggct ttttcttggc ggagagactg 1529341 ttctgtttgc gtctctcttc gccacgtttc ttgcgcttcg gaattcaaat gccggtgatc 1529401 cgcctacgac ggaaatgttc gatgtgacac ttgtattcat tgccacaatg cttctattaa 1529461 cgagcagttt aacgagtgtg tacgcgatgt accacatgaa gaacttttcc ttcggcaaga 1529521 tgcagctttg gctgggaatt acgattttat tgggggcggg ctttttagga ctggaaatct 1529581 atgagttcaa gcattacacc catgaatttg gctttaccat cacaagctct gcccttggtt 1529641 ctgcgtttta cacgcttgtc ggtacacacg gcgcccacgt ggcatttggg cttatgtgga 1529701 tcagcacgct tatgatccgc aatgccaaga gagggctgaa tctgtatacg gcgcctaagt 1529761 tttacgttgc cagcctttat tggcacttta ttgatgtcgt gtgggtcttc atctttaccg 1529821 ttgtatattt aatggggatg gtgggataaa catggtcgat aaaaaaagca gagggcatat 1529881 caatagcgac cttgaattta agaaaaaaaa gcatgcccgg gagatgaaat atcaagtcct 1529941 gtcttttggt ttaatgatcg gtcttacgat tgttgcattt ctgactgtgg ccacggacgg 1530001 tgtcggcagc tggtttacga ttcctttcat tattttgcta gctgcaattc aagtcatttt 1530061 tcagctgtat tatttcatgc atatgaatca gaaagggcat gaggcgccgg cactgttttt 1530121 gtattcaggg gtgtttgtcg cgtttatcac tgtgcttgcg tttgtgacaa ttatatggtg 1530181 gtaatttgaa cagccgccgg aggtgaagaa atgaatcagt tggagatatt tgggtttcgc 1530241 gcgatgtgga gcccttatct tttttgtatc ctgttaggca ttacggcgct ttatctctat 1530301 ttttacaggc gaatgtcttc aaagccgaat cgaataactg gtaaagagat ggtgtgcttt 1530361 ctgtcggcga tgctgttttt atatgcagcc gagggaagcc cggttgatct gctcggacat 1530421 attatgttca gtgcgcatat ggtgcagatg gccgtcctgt atttggttgt cccgccgctg 1530481 ttaatcgcgg ggattcctgc atggctctgg gaaaaaatca ttttcaggcc ttcaatcaaa 1530541 ccggtttttt ccttttttac gacgccttta attgctttgc ttttgtttaa cggcattttt 1530601 tctttatatc atgtaccgct tatatttgat actgtcaaaa cagatccgtt ttaccataca 1530661 ttaatcactt ggcttatctt tgtgcttgcg ttcttcatgt ggtggccgct tgttcataag 1530721 gttgagcgtc tacggcagct cagcggcttg atgaagctgg gttatattat ggcggacggt 1530781 atgctgctca cacctgcttg cgccttgatc atgttcagcg gtgcaccgtt atacgccacc 1530841 tatacagatc cggctttatg ggctgaggca atgaggcttt gcgtgccagc ggatatgatg 1530901 gggcaggtcc cattaacagg gccagagatg ttgaatacac tgcctttgtt agaggatcag 1530961 cagctcggag cagtcatgat gaaaatcatt caggaaattg tgtacggtac ttttttggcc 1531021 gttatttttt tccaatgggt gaagaaagaa agggaaaagg acgggcagga ggagccgccg 1531081 tatattcagc agacgatatc ataaaaggta cagcgaaata tgctgtacct tttcgttaca 1531141 tttgaactgt ttttaacatg ttggctatgt cctgaatcag tgccttgctt tttgtcacaa 1531201 cctgtacggg aaactcttcc gtttctccat attctactcc atgagggtag taatgctttc 1531261 ctaggagagg ggacattaat tgaatcacgg cgcgcccgct tccgacatcg ccttctgccg 1531321 caataccttg tatccgcagg taaaacgtac cctcaatcgt cgaaaacttc ttgtcatagg 1531381 tgactctctc gtaatcccat tgacccgctc tgataagacc tttgctttcc attaagtcgt 1531441 ctagccagct gagctcagcc ttaacccctt caagtccgct ttcagtaaac ttcaacactg 1531501 acccctcctt ataaaaatta cctttcctga caatcatagt atgaaagcgt taaactttca 1531561 atgaatcttc ttcttttgaa agtatgcaaa aattaaattt tgacgacaat agcactagac 1531621 taaaggaggt taaacggatg acaaaaataa aagatctgat gacagccgac ttgcaatatt 1531681 gcacggtatt agataatgta tatgaagctg cagtaaagat gaaggacgca aatgtaggag 1531741 cgataccggt agttgatgag gacggggaaa cattggtcgg catcgtaacc gaccgcgatc 1531801 tcgtattaag aggaatcgcc atcaaaaaac cgaactcgca aaaaatcact gacgcgatga 1531861 ctgaaaaacc tgtcagtgtg gaggaagatg cttcagtcga tgaggttctt catttgatgg 1531921 catcgcatca gctcagaagg ataccagtta caaaaaataa aaaactgact ggaattgtca 1531981 cgcttggtga tctttcttta tctgagcaaa cgaatgaacg tgccggcagc gccttatcgg 1532041 atatttccga aggggataat agagaagaag gcttttttca ttaacacata aatctttgac 1532101 atgttaaata ggctgtattg taatgggatg taaacaagag attgtgaatc gccacggggg 1532161 tgatagattg aaaaatatat tgagagcaat ggttatcctt ttgattatct gcggaaccta 1532221 tgttctgttt attcaatatg gatctgttcc tgaaaagaaa tcaaatgaca gcgagcctca 1532281 ggtgtcgaat gaggaagcgc aaagcggcaa acgaatacat atgccgactt cagggttatt 1532341 gtccttcatg ggcaagcacg ccgatgaagt aacgaaaaag cttggggaac ctgaacgtat 1532401 tgacccttcg gcttatgatt acgattggtg ggtatacaat caaggtaagg atcaatatat 1532461 ccaaatcggg gtattaaaca ataaagtggt cacattattc gcgtcgggta atgatattaa 1532521 cgccaagcct ttcaaaattg gagaatcaac tggcgaagta ttcaagacca cccaggtggc 1532581 accatttgtg aatgtagagt ataaaggaaa ttcctatcgg tttgaatttt ctgaagaaga 1532641 tatcaataca agaccgactg taaaggtagg aaagatgtat gtccagctgt atatggacaa 1532701 atttgagggg aagctatcca gcatcagggc gtttgatgcg cagacctttg taaagcaaag 1532761 accttatgag gtagtgtacc gcggggaatt aattaaaccg aaagccgttt cagatgagaa 1532821 atggaaaaag atccaaacaa cgagcgaaaa gcaaatcctt gatttgacga atgtcatacg 1532881 cgttaaacat ggacttgcga agcttgagtg ggatcagcca acggcggaag tggcatttgg 1532941 gcatagtgag gatatgaagg aaaataatta tttctcccat gtctctaaaa aatacggctc 1533001 gctgaaagac cgcttagaag aagggcatgt tgattttcag caagcgggag aaaatatcgc 1533061 atacaattat gtggacggtc cggctgctgt agaaggctgg ctgaatagcg aaggccatcg 1533121 aaaagcgctt ctgaattcag attatacgca tcttggtgtc ggagtagacc ggaaatatta 1533181 cacccaaaac tttattaagc gatggtaatg aaagccgcgg acgaatggtt cccggctttt 1533241 tctatttcca tacaagctgg tctgaatgaa tgtgctgata gcttacagat aaggccgttt 1533301 cccatccctt cagtcaggct ttttcaccag tgtataggga tatcgctaaa aattcatttg 1533361 ggaatgaata taggcgaaca caatgcccga caaaacgata cattgtagta ggtaacgatt 1533421 ttcggagggg gtgaggattg tggcgaatca acatgccaat cattcaatca atgactttaa 1533481 acaattcgtc aaaaagcatc ccaagctgat aaaagaagtg cgcaaagaac aaagaagctg 1533541 gcaggacgta tatgaaaatt gggtcctctt cggggagagc gacccgattt gggatccata 1533601 tcgggaaccg gaagaagctt ctgaagctgt gcctgaaaca ccgcaaaaaa atgattttgt 1533661 ctcgaaaatg gtgacagcgg tgaaaaagat ggatgtcaat caaatgaacg aacaaatcaa 1533721 taaaatgagc cagtcgatct catcgttgca aagccttctt aatacatttt ccggaagcgg 1533781 acagaagcat tctcagccag gctctggaca gcatcctttt tcttttcgaa aggattaaaa 1533841 aaggggagct catatgcgca aagaggttca ggaatatatt ttagcaaacg aagaacggaa 1533901 acgattcatc agagaacagc cgatatggta ccgcaggctt tcaagaaaac cggatgatct 1533961 gtcctccttt cagcttgaaa tgatgaattt ttatgaaaaa accattccgc atcgggtgaa 1534021 tcagtttacg aacgggattc aaatggcgca aatgatgatg caaatgtttc aagcgatgcg 1534081 gacaaaagat taaaaggccc cgaagaaggg tcttttttca tgcggtcata aggttttgtt 1534141 ggcggctgcg gttaagcatt ttccaattgg ctggtttcat ggtaaactaa caactggagg 1534201 tgcatgttat gtatgcgacg atggaatccg tgcggcttca aagtgaagct cagcagcttg 1534261 ccgagatgat tctgcagtcg gagacggctg agaactaccg caattgttac aagcgtctcc 1534321 aggaagatga agaggcaggt cggattattc gttcttttat caaaataaaa gagcagtatg 1534381 aggatgtaca gcgttttggc aaatatcatc ctgactatag agaaatatcc cggaaaatga 1534441 gggagatcaa acgtgagctg gacctgaacg ataaggtggc tgacttcaag agagctgaaa 1534501 atgagctcca gtccattctt gatgaggtca gcgttgagat tgggacagct gtttcggagc 1534561 atgtgaaagt tccgactggg aacccttatt ttgacggttt gtcttcatgc ggaggcggct 1534621 gcggttcagg cggaagctgc ggatgtaaag tgtcctgacg agactggccg tctcgtcttt 1534681 tacatataag agaaaacagg caggtgattg tattggagaa taggcgccag ggcatggttg 1534741 tgtatctgca ctccctaaag cagagcaaaa tgctgaggaa gttcgggaat gtgcactatg 1534801 tatcaaaacg attaaaatat gtcgtactgt actgtgatat ggaccaaatt gaaaaaacaa 1534861 tggacaagat tgcgtcttac tcatttgtga aaaaagtgga gccttcttat aaaccgtttt 1534921 taaaattgga attcgagtca aagcttgata aggcaaaaga atacgattat aaaatcggca 1534981 tatagctata aaaaaatccc cgcaggcatc tgcggggtcc ttctattcct taatatgtta 1535041 aggagaaggc aaagggagag gagaaaccgg aggaagaact tatggggaaa cgtaagtctt 1535101 ctccgcggtt ggcaacaaca tcctctagat gctgttgctt atagtatgga caaggatcat 1535161 gctgcctata cacctgttta tcaagattag cgttcattgt ttggaagaat gctttatgtt 1535221 aagataggat tgattttttt ctatgtacat agcggcgtcc ggccgaataa agaaacaaaa 1535281 tagcttttag aaaaagtggt gtggaacatg agagtaattt ctggatcaaa aaaaggccgt 1535341 tcactaaagg ctgtagccgg aacatcaaca agaccgacaa ccgacaaagt gaaggaatcc 1535401 attttcaata tgatcggccc ttattttgac gggggcaggg gacttgactt attcgcaggg 1535461 agcggaggtc ttggaatcga agcgctttca cgcgggtttg agcattgtat attcgttgac 1535521 cgtgatttta aagcgattca aacggtaaaa tctaatttga aaacgctgga gcttacaaaa 1535581 catgcacagg tataccgcaa tgatgcggaa cgtgctttgc acgctgctgc taaaagagaa 1535641 accggctttc gcggaatttt tctcgatccg ccgtataagg aacaaaagct gaaagcactt 1535701 ttaactttga ttgacgaata tcaaatgctg gaagaagacg gctttatcgt cgctgagcat 1535761 gacagagagg tcgagcttcc cgaaaccgta ggagatcttg tgatgacaag aaaagaaacc 1535821 tatgggttaa caggtgtagc gatttataaa aagagggggt agtgaggtgg cgagtatagc 1535881 tgtctgtccc ggcagttttg atcctgtgac ctacgggcat ctggacatca tcaaacgcgg 1535941 ggcgcatatt tttgaacaag tgtatgtatg tgtgctgaat aattcttcaa aaaagccttt 1536001 gttcagtgtg gaagaacggt gtgagcttct gagagaagtc acaaaagaca ttccgaacat 1536061 aacagttgaa acatcgcaag gcctgttaat tgattatgca aaaagaaaaa atgcgaaagc 1536121 gattttaaga ggcttgagag ctgtatctga ttttgaatac gagatgcagg ggacatcagt 1536181 aaaccgggtg cttgatgaat ctattgagac gttttttatg atgacaaaca atcaatattc 1536241 gtttctaagt tcaagcatcg taaaagaagt ggcaagatac aacggctcgg tatcagagtt 1536301 tgtaccgccg gaagtagagt tggcgcttca gcaaaaattc agacaaggat gagggttttg 1536361 actcatcctt tttttgttcc gtttgtcagt ctgtaagaaa aaatgataat gtacgtaaac 1536421 agcgcgcata gtgtgacagc aggtccgatc tgcacaagca gattccagcc gtttataaag 1536481 gcagttgaca tgtcactgct gttaagagat ttaaatacat actgatacgg atcatgccat 1536541 gctgtgtaaa gaggtttcca taaaagcatg acgaagacag cggcataaac gccctgcagc 1536601 aaacgtgcga taaagaatgg tttaaatcta atgtcggttt ccgataaaat acctgccacc 1536661 tgagcttgta cggaaaagcc gctaaaccca agaataaagc tgacgataat ggctttttgc 1536721 agaagagaaa catctgtctc gctgacaagc ttgctgccta atgtaatttc aaacatccct 1536781 gataaaagcg gaatgtccaa ttgagtcgga agctgaaaca aagtcagtgc tccttttgtg 1536841 aaaacagaca aaacatcagt cagctggacc actgacaaca gccgattgaa gacagaaaat 1536901 aaaataataa agccgcctac cataagaagc gtttgaacag aagacgtcac ggcgtcgcct 1536961 aaaattttac ctaagggccg tttttctgca agtctggcgg tatgaagagc gtgtaaagca 1537021 tctttgactg aagggaaagg tatcgttttc tttcttctga gatgctgctc ttccttgcgg 1537081 ccataggagc gcattgttaa accgacggca agattcccca aatagtgtgc agaagctaat 1537141 aaaatgccta gtgatgcgtt ttgaaagaaa ccgacggcaa cagcgccgaa aataaagagc 1537201 gggtttgaag aattggtaaa cgacgcgagc cgttctgcct ctactcttga aatctgattt 1537261 tcctgccgca gacgggcagt gagttttgcg cccgctgggt ttcctgatgc cattcccata 1537321 gcaagaacga agccgccgac acccggcacg cgaaagatcg gccgcataaa aggctcaagc 1537381 aaaacaccga caaaccgcac aatgccaaag ccgattaaga gttcggacag aataaaaaat 1537441 ggcagcaatg acggaaacac aacctcccac cacatagaca gcccggtttt agaggcttcg 1537501 aatgaggcct gtggatgtga gatgacagtc gctgttaaaa aaagaaaaaa cgaggcaatc 1537561 aaaagtgtat taatcttcga caagttcatt cttacctccc cgatgctaaa aatgcccaat 1537621 gacatgtata tcatgataaa ataatgtatg atgtaaaacg gccaagcagt acctgtcctc 1537681 ttgattcttt gtactaatat acgagcatag gggttcagtt tagaccatag aattcggtat 1537741 acagggaatt caggcaggag gttaacgctt tggccaaacc taaaatcggg ttagcgttag 1537801 gatcgggagg ggccagaggg cttgctcatc tcggtgtgct ttccagttta cataagcacc 1537861 aaattgaagt ggatatgatt gcaggaagca gcatgggcgc tttggtgggc agtttttacg 1537921 ccgccggaca tgacgtggca acgatgaaaa aagtagccaa agcctttaaa cgaaggcttt 1537981 atgctgatta tacggtgccg aaactcggtt ttttaaaagg tgaccgcgtc agacagcttg 1538041 tgcatgctta tacattcgga aaaccgattg aagagctcca aatcccgctg ggcattgttg 1538101 cgtgtgatct acagacggga gaaaagattg tgttccgaaa aggatcagtg tcagatgcag 1538161 tgagggccag catcagcatc ccgggtatct ttattccgca gcggctggac ggacgccttc 1538221 ttgtagacgg cgcggtcgtc gatcgaattc cggtttctgt tgtgaaagac atgggagctg 1538281 atattatcat cgcttcggat gtttccaggg ttcgaaaaac tgaaacagca gtgcatattt 1538341 ttgatgtgat tatgcaaagt atggatatac tgcaaaatga attagtgcgg catcaaacaa 1538401 ttgccgcaga tatcatgatt cgcccttccc ttgaaacata cagctcaagc tcgtttgcca 1538461 atattgaaga aatgatatcg gcaggcgaag aggcgacaaa ccgaatgatc agcaagataa 1538521 gaaaagaaat agagaattgg gagggctcat aatttgctac gtaaaaaaca ttttagctgg 1538581 atgctcgtca tcctcatact gatcgccgtt ttatcattta taaaacttcc atactatatt 1538641 acaaaaccgg gagaagcgac agagcttgct tcattgataa aagtggaggg aggctacccg 1538701 gaaaaaggaa gtctgtcctt aatgactgtt aaagtgggac cggctaatcc atttacatat 1538761 gtgtgggcaa agatgcaccc ttattatgaa attgttcctg atgagagcat taaggaggaa 1538821 ggcgaatcag ataaggagta tatgaaaaga cagctccaaa tgatgaaaag ctcgcaagaa 1538881 aatgcggtta tagccgccta tcaaaaggca ggaaaaaaag tcagctattc ctttaacggc 1538941 atatacgcaa gctcagttgt agaaaacatg ccggcaaaag ggaaaataga agtcggtgat 1539001 aaaatcatca gcgcagacgg caaaaactat cagtctgctg aaaagctgat tgattatatc 1539061 agcagcaaaa aagcgggaga taaagtcacg ttaaagatcg aaagagaaga aaaagaaaag 1539121 cgtgtcaccc ttacgttaaa acaatttcct gatgagccgg atcgggcagg aatcggagtt 1539181 tcgctttata cagacagaaa cgtgaaggta gagcctgata ttgattttga aatcgaaaat 1539241 attggcggcc cgtcagcagg gttaatgatg tcccttgaaa tctataatca gctgacaaaa 1539301 ccagacgaaa caaaaggcta cgatattgcg ggaacaggta cgattgatgt tgacggaaaa 1539361 gtaggcccga tcggcggcat tgatcaaaaa gtcgtcgccg cagacaaagc cggaaaagac 1539421 attttcttcg cgccaaatca aaacggcgcc agcaattccg attataagaa cgcagtaaaa 1539481 acagcaaaag atattgattc aaatatgaag attgtgcctg ttgataccat gcaggatgcg 1539541 attgattatt tgaataagct gaaagcgaaa agcacctgat tctcaggtgc tttttctata 1539601 catttaaaaa gtgttgttca tcttcgtcat atcgaatcgg tgcatgtccg tattcctgta 1539661 ggtcaaactc agttctcagc ggctcttcta tcggcaggct gtaaatcctg cttgctttta 1539721 cgtccagatc gagagctgga tgggagaaag aggacagttt gctgacaagc ggaacagaca 1539781 gtgctttttt cttttcggat aaataagcct gtcctttttt cgtcatgccg agaagcctga 1539841 tatacggcgc cttatcgttg tcaagcagct tttgcatatc ctgttttttt gttctggtta 1539901 aaatgtgtgt attcatccgc tggagccttg tccacgtata gcgttttgtt ttcagcagtt 1539961 ccataaattc ctgataggag ctggattttc tgatcgaacg aataattctg tgctctaaac 1540021 cttcctccac ctcgtatact tgctgtaatt cccgtgccgt tacagttgaa aggctgtatt 1540081 ttaagtaaga aaagtagctt tcaggtgtat gccacaatcc gaaagatttg cggtaagctg 1540141 ctaattcacg tgcagatgca gcagggagaa aacgaaggca ggcttcgaga ttctggccaa 1540201 tcatcgcttt tctaatgctt gtggcacttg ctatatggtt ttcgccttca gggagatcgg 1540261 catcatgata gtccgaagag attcgtgccg tagtataagg tttcatagga tatcccccgg 1540321 ttagaatcga ggtcacatac tggtatccca aaatgttatt tggttttgac aagtcaagtg 1540381 cactttcagt atgcaaaatg gagctgaagg cgatagccgc cgctgctggg taactggccc 1540441 cctttttaag ttcttcttta attcggtcat tcaatatatg tttatgctca tcaataagct 1540501 gtgctgtttc taaaaaaggc ttgatatccc cattttcact cccgaaaaac agcgcctcac 1540561 attcaagttc gttcaggatg gaaacactgc cgcgtgcaaa aatgtctgct ttttgcacgg 1540621 cataaagata aggcagctca atgacaagat caactccgct ttgcagcgcc atttttgttc 1540681 gggcccattt tgatacaaca gcgggttccc cgcgctgtaa aaaatgtccg ctcatgaccg 1540741 cgacagccgt gtcacatccg gtttgcagct ttgctgtttg ggcatgataa aggtgaccgt 1540801 tatgaaaggg attatattca accaccaatc cgacagcttt catatttttt ccgcctttct 1540861 tgctatgttt aaaaacgtat ggtacatttg caaatgaaaa ctcttacgcc ttatttttgt 1540921 tttaagtgta tgcatagcat attccgctgt caacgatact tcaatggcag cattatgctg 1540981 taaagaaaaa atattgacaa aaacaatctt aaaagctata atcatgtttg ttgctttcct 1541041 gaggtgatac aaatgaaatg gacgatttat cagctgcatc aaatgccaaa acaaagtttt 1541101 gagtttgatg aaacagttga gttaaatgag ctgacaaagc tgaattctga cattcgccgc 1541161 atttctcccg ttcgggtgaa gggcagagcg gatatcaaat ccaaacaggt ttcgtttgat 1541221 tttacaattt caggcgaaat gcttttgcca tgctcaagaa cactcgttga tgttccgtat 1541281 ccatttgaaa tttcaacaaa agaactgttt atatttcatc acacggatga tatagaagat 1541341 gatgacgttc acattgttga ggacgatact atcgacataa ctccgatcgt gaaagaagaa 1541401 attcttttag aaatccctat gcaaatcttt tgtgaatctg aacaagaaaa aggagctgct 1541461 cctcaagaag gaaaggattg gcaagtcatt tcggaagaag acaagaagaa tcaagttgat 1541521 ccgagacttg cagcccttga aaagctctta aaacaagatg atgaatctta actctttaag 1541581 gaggtgggaa taatggctgt accttttaga agaacttcta aaatgaagaa aagattgcgc 1541641 cgtacacatt tcaaacttaa tgtacctggt atgacagaat gtccgtcatg cggagagatg 1541701 aagttgtctc accgtgtatg caaagcatgc ggatcataca acggcaaaga cataaatgta 1541761 aaaagtaact aatgagaaaa gcgcagggtg aaagccctgc gctttttctt tttctcttcc 1541821 tgtcagcttg cggaaaattt gtgagtgcaa atagtctatc taatctatta ccggcatatg 1541881 tatgagataa ataagctgac atggagggag attgaatttg accattacaa gacaagatgc 1541941 ttggactcag gatgaggatt tgctgctggc agaagtggtg cttcgtcata ttcgagaggg 1542001 aggaacacag ctttcagcct ttgaggaggt tggaagggcg ctgaccagaa ccgcggcagc 1542061 ctgtggtttc aggtggaact cgtatgtgag aaaacaatac cagtcaggta tagagcttgc 1542121 aaaaaagcaa aggaaagaac tgagaaagca aatcggcgtt cattcggtca atatgccgaa 1542181 ttccatgaag cagactgcct cggcatcgtc agaaggaaaa cgagatttgt ccattcagga 1542241 tgtcattcaa tttctcgaac aattcaaaga aacaccgtct gcacaagaat ttcagcttga 1542301 aagggaaaaa ttgaaggagc aaatccaatc gctgcaaaaa gagcttgagg atttgcggag 1542361 tgaaaatcag acattgcgga atcagctaga gatgacagaa gaggattaca aggcactgat 1542421 cgatatcatg gatcgggcca gaaaaatggt tgtttcgaag gaagacggaa gaatgaaaaa 1542481 agcggctcaa gaaacgtaaa gaaacgcctg aaatgaaccg gccctatagt aagaataggc 1542541 cggttgtttt gatttctatg cagactctcc cggtgtcatt tcgcgatcca tatcaggatg 1542601 ccagatgagc gggttttccc ctttgtcccg cgccatatca tacttaacag ttttaaagtt 1542661 cattttgttc caaaattccg ctgatttcat tctcggattt gtccggatcg gcattttgaa 1542721 tgattttgca aattcaacca aggctctccc gtatcccctg ttctggtagc ccggaagaac 1542781 ctcaagcttc cacagctcca aataatcctg gcggttgtca aaatagggat tcgatttgcc 1542841 gttaacttga tacagactca ttcgtgctac aagtttatcg ccaaaataaa tcccgtaaaa 1542901 aggcgaggtg ctgtcatttt caataatatt atcctgaagt tcttcaagca ttgaaagctc 1542961 ctgaatgccg tattctttga atttcttgaa ttcttccagc gttttatagt tgataagcag 1543021 acgttctacc tttgtcaaac aaatctcccc ctttgttgtt tctacatata ttgtaaacgc 1543081 tttatttaaa aaatccaaat atttaaactt taattttaag cacatgggat ctttgagaag 1543141 taatttcttc ttacttctgc tatgataata cgtaaatgct aaattgggtg tgacatcatg 1543201 aaaattggaa ttatcggcgg aggctccgtt ggtcttttat gcgcctatta tttgtcactt 1543261 tatcacgacg tgactgttgt gacgaggcgg caagaacagg ctgcggccat tcagtctgaa 1543321 ggaatccggc tttataaagg cggggaggaa ttcagggctg attgcagtgc ggacacgagt 1543381 atcaattcgg actttgacct gcttgtcgtg acagtgaagc agcatcagct tcaatctgtt 1543441 ttttcgtcgc ttgaacgaat cgggaagacg aatatattat ttttgcaaaa cggcatgggg 1543501 catatccacg acctaaaaga ctggcacgtt ggccattcca tttatgttgg aatcgttgag 1543561 cacggagctg taagaaaatc ggatacagct gttgatcata caggcctagg tgcgataaaa 1543621 tggagcgcgt tcgacgatgc tgaaccagac cggctgaaca tcttgtttca gcataaccat 1543681 tcggattttc cgatttatta tgagacggat tggtaccgtc tgctgacggg caagctgatt 1543741 gtaaatgcgt gtattaatcc tttaactgcg ttattgcaag tgaaaaatgg agaactgctg 1543801 acaacgccag cttatctggc ttttatgaag ctggtatttc aggaggcatg ccgcatttta 1543861 aaacttgaaa atgaagaaaa ggcttgggag cgggttcagg ccgtttgtgg gcaaacgaaa 1543921 gagaatcgtt catcaatgct ggttgacgtc attggaggcc ggcagacgga agctgacgcc 1543981 attatcggat acttattgaa ggaagcaagt cttcaaggtc ttgatgccgt ccacctagag 1544041 tttttatatg gcagcatcaa agcattggag cgaaatacaa acaaagtctt ttgagctttt 1544101 tcggtaacat gctatactca tttcggatca ctaactattt attggagaaa ggaagttcta 1544161 gaagatgcag ctaactgaac tttccatcaa aaatcagaat gtgtttgtac agcactatat 1544221 agatggcaaa gaagaaatgt cttctttttt tgattacagt attcatcata aggacatgtg 1544281 gcgcgaaaga ctggaagact tatcttcccg gtttttcgca agagaggaat tggcggcgta 1544341 cttaacctct taccataata aattcggttc aagtgcgatg cagtctgcta ttgagaagct 1544401 gaaggacccg tcaagtgccg ctgtagtcgg cggacagcag gcaggacttt taacaggacc 1544461 gctttacacc atacataaaa tcatttcaat cattgtttta gcaaagcaac aagaaaagga 1544521 actgcaagtg cctgtcatac caatcttctg ggtggctgga gaagaccacg atttggatga 1544581 gattaatttt gttcacacat ctgaagagaa tgggcctgtg aaaaaaaagc tgcctcagtc 1544641 ttattggaag aaatcatcag cagcgagtac atcgcttgat caggaaaagt gtgccgcgtg 1544701 gatagatgat gtttttgccg cttttgaaga aacagaccat acgaatacac ttctcgacaa 1544761 tgtgaaacga tgtttaaggg aatctgttac gtttactgac ttctttgaac tgctgatcgc 1544821 ggatttgttc caagaagagg gcttagtttt attaaattct ggggatccgg ggattaaaaa 1544881 gctggaaacg gccatgttcc aaaagattct tcgagaaaat gatgaactcg cccgggctgt 1544941 atcagatcag caggccttca tgcgtcaagc aggctacaaa ccgattatcg agtccggaaa 1545001 agagcaggcg aatctgtttt atgaatacga agatgagcgt tttttaattg aaaaagataa 1545061 cggccgattt gtcatcaaag agcttgatct aggatggacg agggatgaac ttcatacaca 1545121 tatggaagaa catccagagc gtttcagcaa caatgttgta acgagaccgt taatgcagga 1545181 atttctcatt ccgactttag catttattgc agggcctggg gaaatcaatt attggggcga 1545241 gctcaaacag gcatttgcgg tgatgggctt caaaatgcct cctgtcatgc caaggctgaa 1545301 cattacgata cttgagcggc atattgagaa aaaactggct gaacggaata tctcattaca 1545361 agacgcgatt gagcgcggaa cggagaatca aagagagaca tacttcgagc gccagattcc 1545421 ggaagagttt acggcggtga tggatcaggc gaaaagccaa attgaagcga ttcacaaaac 1545481 ggtccggcag gaggcgttaa aggttgatca aagcttggaa cctttacttc tgaaaaatgc 1545541 cgcttttatt caggatcagc ttcaattctt agagcgcacg gtgatgaagc gaattgaaga 1545601 aaaagaaggc tacgtcttga aggattatga aagaattcaa aatagcatta agccgcttct 1545661 tgcgccgcaa gaacggattt ggaatatcat gtattatttg aacaggtacg gtccaaaatt 1545721 cttcacgaca ttcaagaatc tgccattttc ttttcaaaat caacatcaag ttgtcaaact 1545781 ttgaaataaa gttttaaaga accctgacta gttcagggtt tttttttatg ggtaaacagt 1545841 gtaaaatgaa gttgtggagc gaagtggtga atagtggtga gttaaggaga gaaagtgggg 1545901 caagagatca tgtttatggg tgaatatcag cataccatcg atgcgaaagg ccgcatgatc 1545961 gtacccgcta aattcagaga aggcctaggt gagcaatttg tgctgactag aggacttgac 1546021 caatgtctct tcggctaccc tatgcacgaa tggaaacaaa ttgaagaaaa actaaaagct 1546081 cttcctctca caaagaaaga tgcccgcgcg tttacccgtt tcttcttttc aggggcgact 1546141 gaatgcgaac tggataagca aggcagggta aatatcgcat catctctatt gaattacgcc 1546201 aaactggaaa aagaatgtgt tgttatcggg gtttctaatc gaattgaatt gtggagtaaa 1546261 gtaatttggg aacaatacac agaagagcaa gaagattcat ttgctgaaat tgctgaaaac 1546321 atgattgggt ttgatatata atgattcttc gtgtataaca ctctaaaaac aatttcaatt 1546381 catcctgata aaaggtggga ccaacacaat atgtttcaac acaagacagt acttcttcgt 1546441 gaaaccgtag acggacttaa tattaaacca gacggtacat atgtagactg cacactcggc 1546501 ggagctgggc atagtacata cttattgcag cagttatccg agaaggggcg tttaatcgct 1546561 tttgaccaag atgatacggc attacagcat gctaaagaag tgttgtccga ttataaagga 1546621 cagctcattc tgattaaaag caatttcagg tatttaaaag aatatttgaa tgaacaaggc 1546681 gttacagaag tagacggcat tttatttgat ttaggggtgt cctctccgca gctggataca 1546741 ccggagcgcg gattcagtta ccatcatgac gcaccgttgg acatgaggat ggaccagtcg 1546801 gctacgcttt cggcgaaaga agtcgttaat gagtggcgct atgaggatct cgtccgtatt 1546861 ttctttaaat acggagaaga gaagttcagt aaacagatcg ccagaaaaat tgaggaggca 1546921 agaatgaagt ctcctattca aactacgggc caactggtcg atctaataaa agacgcgatt 1546981 cccgctccag cgagaaggag cgggggacat cccgctaaac gcgtgtttca ggcaatcaga 1547041 attgccgtaa acgatgaact tagggtgttt gaagaagctt tggagcaggc aattgaggtt 1547101 ctgaagccag ggggcagggt atcggtcatt accttccact cgctagaaga cagaatttgc 1547161 aaaaccactt ttaaagaaaa gtcgtcgctt ccggaacttc ctccgggact tcctgttata 1547221 ccggaagagt ttgaaccgga gctgaagctc atcacacgaa aaccgattac ggcatctcaa 1547281 gaagagcttg aagagaacaa ccgggctcgt tctgccaagc ttcggattgc tgaaaaaaga 1547341 aaataacgaa acgcgaacgc aaaattaaaa ggaggtcatc agcctatgag caatttagct 1547401 taccaaccag agaaacagca gcggcatgcg atcagtcctg agaaaaaagt gattgtcaag 1547461 aaaagggctt ccattactct cggagaaaaa gtgcttcttg tcctctttgc tgcggcggtg 1547521 ctcagcgtat cgcttttgat cgtatcgaag gcgtatgcgg catatcaaac caatattgag 1547581 gtgcaaaagc ttgaggagca aatttcatcc gaaaataagc aaattggtga cctcgaaaaa 1547641 agcgttgctg atttaagcaa accgcagcgc attatggaca ttgcgaaaaa gaacggcttg 1547701 aatttaaaag ataaaaaagt gaaaaacata caggaatgat tcaaatgcca aaaaagaata 1547761 aatttatgaa tagaggagca gcgattctaa gtatttgttt cgctctcttt ttctttgtca 1547821 tcctggggag aatggcatat attcaaataa ccggaaaagc gaacggcgaa gtgcttgcga 1547881 caaaagcgac agagcagcat gaaaagaaac ggaccatcga agcgagccgc ggctcgattt 1547941 tagaccgaaa aggaaaagtc attgcagagg acacagcgac gtataaactg attgcgattc 1548001 tcgataaaaa aatgaccact gatgtcaagc atcctcagca tgttgtaaac aaagaaaaaa 1548061 cggcggaagc attgtctaaa gtgataaact tggacaaggc cgacatcctt gatatcttaa 1548121 ataaagatgc aaaacaagtc gagtttggct cagctggccg ggatattacg tattcacaaa 1548181 agcaaaaaat cgaaaaaatg aaactcccgg gcatttcatt tttacgggat acaaaacgct 1548241 actatccaaa cggagtattt gcatctaatc taatcggcta tgccgaggtt gatgaagaaa 1548301 caaatgaaat ttccggcgcg atgggattag aaaaagtgct ggataagtat ttgaaggagc 1548361 gggacggata tgtgacatat gaaagcgaca aatccggctg ggagctcccg aacagcaaaa 1548421 ataaaattac agcgccaaaa aatggtgaca atgtatattt aaccattgac cagaaaattc 1548481 aaaccttttt ggaagacagc atgacaaaag tggcgcaaaa gtataatccg aaaaaaatca 1548541 tggccgcagt cgttgatccg aaaacgggca aagtccttgc catgggacag cgcccaagct 1548601 ttgatccgaa caagcgcgat gtgacaaact actataatga tttgatttca tatgcgtatg 1548661 aacccgggtc cacgatgaag atctttacac tcgctgctgc gatgcaggaa aacgtgttta 1548721 atgcgaacga aaaatataaa tcagggacat ttgaagttgg cggagcacct gttaaggatc 1548781 acaataacgg tgtaggctgg ggtccgacaa catatcatga cggcgtccta aggtcgtcga 1548841 atgtcgcttt tgcgaaactg gcgaaagaaa agctgggata tgaccgcctc aatcaatatt 1548901 tgcacaaatt caatttttac cagaaaacag gtattgattt gccaggagaa gtctccagca 1548961 aaatcaactt taaatatgaa tttgataagg cgtcaactgc atatggccaa gcgtctgcgg 1549021 tcacaccaat tcagcagatt caggccgcaa cggcaattgc aaatgacggt aaaatgatga 1549081 aaccttatgt cattgaccat atcgttgacc ctgataaaga taaaactatt tatcaaaata 1549141 agccggaatc agccggaact ccaatttctg caagtactgc gaaaaaggtg cgggatatat 1549201 taggagaagt cgttacatcg aagatcggaa cagggcaagc ttataaaatc gaaggttttg 1549261 atgttgccgg gaaaacaggt actgcgcaaa tagccggtaa aggcggatat ttagacggca 1549321 cagataacta tatcttttcg tttatgggta tggcgccaaa agatgatcct gagcttttaa 1549381 tttatgttgc tgtacagcag ccgcaactaa aagcaggaca aagcagttca gatccagtat 1549441 cagaaatctt caatccaaca atgaaaaata gcctgcacta cctaaacatc gaaccaactg 1549501 aaaaatctga ctcagataag gaagaaacaa aagcgcagac aatgcctgat ttaacagatc 1549561 aaacggtagc tgctgctcaa aagaaagcaa aagaggagaa tctcacacca attgtcatcg 1549621 gcagtgatgt cgctgtaaaa gaacagtatc cgaaagcgga tgaggaagtt ctcaccaatc 1549681 aaaaggtctt cctgaaaacg ggcggcaaaa tcaaaatgcc tgatatgaca ggctggtcga 1549741 gaagagaggt tctgcagtac ggcgagctcg cgggaattca tattgaagta agcggacaag 1549801 gctacgctgt cagccaaagt gttaagaaag acaaagaaat caaagacaaa accgtaatca 1549861 aggttaagtt taaaaatcct gattaaaaag aaagccgtcg ttatgcaggc tttctttttt 1549921 tatgccttca gaggagcatc gttctacctg tccaaattca ggcataaaat gaaacaagcc 1549981 taaataagga gtgaacggtc tcttgcgcgt ctcgaatgta acggttagaa aacgtttatt 1550041 atttgttttg ctttttggcg tgatcgtgtt tctgatcatt gatacaaggc tggggtatgt 1550101 tcagtttgtg atgggcgaaa aactgacttc gctagcgaaa gattcctgga gccggaactt 1550161 gccgtttgag ccggagagag gcgagattct ggatcggaat ggtgtgaagc tcgcaacaaa 1550221 taaaagtgcg ccgaccgtat tcgtcgtgcc gcgccaagtt cagaatccga tgaaaacgag 1550281 caagcagctt gcggcggtgc tcaatatgtc agaagaaaaa gtatataaac atgtgacaaa 1550341 aaaagcgtca atcgaaaaga tcactcctga agggagaaaa atttcaaatg agaaggcgaa 1550401 agaaatcaaa gcgcttgatt taaaaggtgt gtatgttgcg gaggacagta tccgtcatta 1550461 cccgttcggc agctttttat ctcatgtgct tggatttgca ggaattgaca accaagggct 1550521 ccttggactt gaagcctatt acgacgatga tttaaaaggg gaaaaaggtt ctgttaagtt 1550581 ttatacagat gccaagggga agaagatgcc tgatgaagcg gatgactata cgccgcctaa 1550641 ggatgggctt gatatgaagc tgacagttga ttcaaaggtt cagacgataa tggaaagaga 1550701 gcttgataac gctgaggcca aatatcatcc ggacggcatg attgccgtag ccatgaatcc 1550761 gaaaaacgga gaaattttgg ggatgtctag caggcctgac ttcgaccctg ctgattacca 1550821 atctgttgat ccgtccgtct acaatcgaaa tctgccagta tggagcacgt atgaaccggg 1550881 atctaccttt aaaattatta cacttgcagc agcccttgaa gagcaaaaag taaatttgaa 1550941 acgggatcaa ttttatgata aagggcatgc tgaagtggac ggagcgagac tgcggtgctg 1551001 gaaaagaggc gggcacgggc tgcagacgta tctggaagtt gtgcagaact cctgcaaccc 1551061 ggggtttgtt gaattaggcg agcgcttagg aaaggaaaag cttttcaaat atatcaaaga 1551121 ctttggtttt ggacaaaaaa cggggattga tctccaaggc gagggaacag gcatcttatt 1551181 cccgcttgag agagtgggcc cggtggagca agcaactacg gctttcggac agggagtatc 1551241 cgtcacgccg attcagcagg ttgcagcagt atccgccgct gtaaacggag gaacgctcta 1551301 tacaccttat attgcaaagg aatggatcga tcctgttacg aagaaaacgg tcaaaaaaca 1551361 atcaccaatc gcaaagaaac aagtcatttc tgaggaaaca tccaaacaaa tccgctatgc 1551421 tctagaaagc gtcgtcgcag aaggaaccgg ccgcaatgca tttgtagaag gatatcgtgt 1551481 cggaggaaaa acgggaactg cacaaaaggt taaagatgga aaatatcttg aaaacaacca 1551541 tattgtatca tttatcggtt tcgcgccagc agatgatccg agtctagtcg tctacgttgc 1551601 ggtggataac ccgaaaggca cgattcagtt tggcggaacg gtggcagcgc ctattgtcgg 1551661 aaatattatg agagacagtc tgccggaact tggtgtgaag ccccggaaaa atcaaatcga 1551721 gaaaaaatac caatggaacg acacaaaaac aatagaagtt ccgaatgttg tagggatgtc 1551781 tgtctcagat cttgagtcac tattggtgaa tctcaatgtg gatgcttccg ggaaagggag 1551841 caaaatcgtt aaacaatcgc cagctgccgg aacgaaagta aaagaaggct caaagatacg 1551901 cgtgtatttg actgaagaag atgaaaagga ggcagccgat tgattcgggc tgcctattct 1551961 tttattgcag aaaaaatgct gatatctttc aagattagct ggatgtatcc ttttatttac 1552021 gctaaaatat gaactgtatg cttaaaatca ttaccacatc atttgatgtg acttcaatga 1552081 taaaaagaac gaattagaat gttgagaggt ttgatacgat gaaacttaca aagctgctta 1552141 catacttaac aaccgaacct tctgtaaacg actcacaaga ccctgaaata acttcaattg 1552201 agatggactc cagggaagta aagaaaggga gtctttttgt atgtgtaaaa gggtatacgg 1552261 tggatggcca cgattttgcg caaaaagcag tagaaaacgg tgcagcggct attgtggcag 1552321 aaagagaggt cgatgtgaat gttcctgtta ttattgtccg gcagtcactt cgcgcgctca 1552381 gcgttttgtc tgatgcgttt tacggacagc cgacgaagaa gcttcagctg attgggataa 1552441 cagggacaaa cggcaaaaca tcaacgaccc acatggtcga tgagattctg aaaaaagcgg 1552501 gaaaacgcac aggcttgatc ggtacaatgt acatgaaaat cggagacgaa acacttcctg 1552561 ttaaaaacac gactccggaa agcgtcacgc tgcagaaaac gtttaagaaa atgaatgaca 1552621 agcacgttga cactgcaatc atggaggttt cttcccacgc tttgtcttta ggacgcgtcc 1552681 atggctgtga ttatgatatt gccgtgttta cgaatttaac acaggaccat ctggactatc 1552741 ataaaacgat ggatgagtac cggcatgcaa aaagcttgct cttttcccaa cttggcgggg 1552801 ctttcaacca tgaacatcca aagcgtgccg tcctgaatgc tgacgatgag gcgagcgctt 1552861 attttgaaaa ggtaacagct gcgcatatct ctacatacgg aattaaaaac gatgctgatg 1552921 tgatggcgaa gaacatcagt atcactgcac agggcacaag ctttgatctc gtgacaaaca 1552981 aaggcacgaa gcacatcacg atgtctctcg tcggacaatt taatgtgtat aacgtgctgg 1553041 ccgctgttgc gacatgtatt gcagcaggca taccgtttga aatcatcact gaggctgttg 1553101 aagaattgca tggtgtaaga ggccgttttg aattggtcaa tcagcagcag gagtttcctg 1553161 tcattgtaga ctacgcgcac acaccggaca gccttgaaaa tgtgctggag acatgcagag 1553221 acatgacgga aggaaagcta tttgtcgttg tcggctgcgg aggagacaga gataagacga 1553281 agcgcccgaa aatggctaaa attgctgtgg agctggctga cgagccgatt ttcacgtcag 1553341 ataacccgag aagcgaagat cctcgcgcga ttttaagaga tatggaagcc ggagtagaga 1553401 acgcatacta tcacagtatt gcaaaccgcg agcaggcgat ctttttcgca attgccaatg 1553461 ccaaaaaagg cgacgttgtc ctcattgccg gaaaaggaca tgaaacctat cagcagatcg 1553521 gaaatgaaac tttcgatttt gatgatgctg aagtagcggc gagagccatt gttgaactca 1553581 ataagaataa gacgaattca taggaaagag atgttactga ataatggagc ttgaaaagat 1553641 ttttcatatg gaaaaaaatc atgaatatga taactacgta tgtcgtttga aagaaacagg 1553701 aggagaaaag gacaatgctt gagcaagtca ttctgtttac aattttaatg gggtttttaa 1553761 ttagtgttct gctctctccg attcttattc cgtttttaag aagattaaaa ttcggccaga 1553821 gtattagaga agaaggaccg aaatcacatc agaaaaaatc agggacaccg acaatgggcg 1553881 gggtcatgat catactttct atcatagtga caacaattgt tatgacacag aagttttcag 1553941 aaataagccc cgaaatggtg ctgcttctgt ttgttacgct aggctacggt ttgcttggct 1554001 ttttagatga ttacatcaag gttgtcatga agcgcaatct tggattgaca tcaaagcaaa 1554061 agctgatcgg acaaattatt attgcggttg tattttacgc cgtgtatcat tactacaatt 1554121 ttgcgacgga tattcgcatt cctggaactg acttatcatt tgatcttggc tgggcttact 1554181 ttatccttgt gctctttatg ctagtcggcg gatcaaacgc agttaacctg actgacggcc 1554241 ttgacgggtt attatccggt actgcggcga ttgcctttgg cgcctttgcc attctggcat 1554301 ggaatcagtc tcaatatgac gtagcgattt tctcagttgc cgttgtcggt gcagttctgg 1554361 gcttccttgt atttaatgct catccggcca aagtttttat gggagatacg ggatcgcttg 1554421 cattgggagg agccatcgtt accattgcca ttttaacgaa attagagatc ctgctggtta 1554481 tcatcggcgg tgtattcgtt atcgagacat tatccgttat tttgcaggtc atcagcttta 1554541 aaacgacagg taaacgaatc tttaaaatga gtccgcttca tcaccattat gagcttgtcg 1554601 gctggtctga atggagagta gtcgtgacgt tttgggctgc gggacttttg cttgccgttt 1554661 taggaattta catcgaggtg tggttataag tggaaaatga tcaattttta cagaaacagc 1554721 attttttaat ccttgggctt gcgaaaagcg gatatgcggc ggcctccatt cttcatgaaa 1554781 aaggcattta tgttgcagtc aatgatcaaa agccttttga agaaaatgaa ccggcacaaa 1554841 agctttctga aaaaggaatc gaagttgttt gcggagagca tccagtttct ctgttcgatc 1554901 agcatcaaat cacgattctg atcaaaaacc cgggaattcc ttatgaaaat atcatggttc 1554961 aggaagcaga gaaacgaggt attccggttt ggacggaaat tgagctcgct tactacctga 1555021 ccagcgccaa gtttatcggg attaccggat cgaacggtaa aacgaccacg acaacgctaa 1555081 tttacgaaat gctcaaggct gactcgcaaa aagcactgat tgccggaaac atcggcacag 1555141 tcgcaagtga ggttgcctat catgctgatg gagatgaatg gatcgttacc gaactgtctt 1555201 cgtttcagct gatgggaaca cacgctttca gaccggaaat cagcctgatt ttaaatgtat 1555261 ttgacgccca tctggattat caccatacgc gcgaaaacta tgaaaaagcg aaacagaaag 1555321 tgtaccttca tcagactgct tcagataaag ctattgtcaa ccaggatgat gaaaccgtcg 1555381 tgcgtcttgc tgaagccgga aaagccgaaa tcgtcccatt ttcagtcagc aaaacgcttg 1555441 aacagggcgc atatgtaaaa gacagtatga ttatgtttaa cggcgaagcc attcttcctc 1555501 tggaagaggt tgtactgccc ggtgctcata acctggagaa cattttagca gctattgcag 1555561 ttgtgaaaac ggcaggagca tccaatgagg cggttaaaaa ggtgctgaca agctttactg 1555621 gtgtgaagca ccgcctccaa tatgtcacaa ctgtgaatgg ccgcaaattt tataacgaca 1555681 gtaaagcaac aaacattctg gcgacaagca aggcgctttc agcttttgat aagccggtca 1555741 ttctgcttgc gggcggactg gatcgcggaa atggttttga tgacttgaaa ccttatatga 1555801 agcatgtcaa agcagtgctt acatttggcc agacggcgcc aaaactcgag aaactcggca 1555861 atgaactggg aatacaacat gtcaaacgtg tcgataatgt tgaacaagca gtatctgcgg 1555921 cgtttgcgct ctcaaatgaa ggagatgtca tcctgctgtc acccgcgtgt gcgagctggg 1555981 atcaattcaa aacatttgaa gaacgcggtg acatgtttat agatgccgtg catatgctta 1556041 agtaagggct tgtcttgaag taaatcggca gccctaatga ctttaagctt ggggtgtcga 1556101 ttgctttgac tactaaaaaa acatcgcctg atttgttatt ggtcatcatt acgttattat 1556161 tattaacaat cggattaatt atggtgtaca gtgcgagtgc ggtatgggcg gattataaat 1556221 ttgacgactc attctttttc gcgaaacggc agcttttgtt tgcgggaatc ggcgtcattg 1556281 ctatgttttt tatcatgaat gttgattatt ggacttggag gacatggtcc aaattgctga 1556341 tggttatctg ctttttcctt ctggtgcttg ttttgatacc gggcgtcgga atggtgcgga 1556401 acggttcaag aagctggatc ggagtcggag cattcagcat acagccttca gagtttatga 1556461 agcttgcgat gattgcattc cttgctaaat ttctctctga aaaacaaaaa aacatcacat 1556521 cgttcagacg ggggttcgtc cctgcacttg gcatcgtgtt ttcagcattt ttgattatca 1556581 tgtgccagcc tgacctcgga acggggacag ttatggtcgg aacttgtatt gtcatgattt 1556641 ttgtagccgg cgcacggatc gcccatttcg tctttctcgg gctgatcggc ctcagcggat 1556701 ttgtcgggct cgtactatcg gctccatatc ggataaagcg gattacctca tacttaaatc 1556761 catgggaaga cccgctcgga agcggatttc agatcattca atcgctttat gcagtggggc 1556821 ccggcgggtt gttcggaatg gggctcggac aaagcagaca gaagttcttt tatctgcctg 1556881 agccgcaaac agactttatt ttcgccatct tgtcagagga gctgggcttt atcgggggaa 1556941 cacttatttt gctcctcttc agcgtcctgc tgtggagagg aatcagaatt gcgcttggtg 1557001 cgcctgatct gtacggaagc tttgtcgcag tcggcattat ttcaatgatt gccattcaag 1557061 tcatgataaa tatcggcgta gtcacgggcc tgattcctgt aacaggcatc acgctcccgt 1557121 ttctgagcta cggaggctct tcattgactc taatgctgat ggcagttggt gtgctgctga 1557181 atgtaagccg ctactcgagg tattaacgaa tgtatttcca agcctcctgt ctaacatgaa 1557241 gcttggaaac aattgatgcg ataaccctgt ccaacaaaac agggttatcg ttatgttata 1557301 gagaaactta gactggggga aaaaagaaat gcgaattgca ataagcggag gcggtacagg 1557361 gggacatatt tatcctgctc ttgcttttat taaagaagtg caaagacgtc atcctaatgt 1557421 ggaattttta tatatcggaa cagaaaacgg gctggagaaa aaaattgttg agcgggagaa 1557481 tataccgttt cgttcaattg aaattacagg atttaaaaga aaattgtcat ttgaaaatgt 1557541 caagactgtg atgcgttttc tgaagggcgt caaaaagagt aaatcgtatt tagcggaatt 1557601 taagcccgat gccgtaattg gaacgggcgg ttatgtatgt gggccggttg tctatgccgc 1557661 tgcgaaaatg ggaattccga ctattgtcca cgaacaaaac agcctgccgg gcatcacgaa 1557721 taagtttctt tcaaaatatg ttaataaagt agcgatttgt tttgaagaag cgaaatcaca 1557781 ttttcctagc gagaaagttg tatttacggg aaacccgaga gcctctgaag tcgtctcaat 1557841 aaagacggga cgatcattgg ctgaatttgg gctttctgaa gacaaaaaaa cggtcttaat 1557901 tttcggcgga agccgaggcg ctgcaccgat taaccgcgct gtcattgaca tgcaggatgt 1557961 gctgaaaaca agagactatc aagtgctgta tatcaccggt gaagttcact atgaaaaagt 1558021 aatgaatgag ctgaaaagca agggtgccgc tgataatatg gtcacaaagc cgtttcttca 1558081 tcaaatgcct gagtatttaa aggccattga tgtcattgtg gccagagccg gtgcgacaac 1558141 gattgccgaa attactgctc tcggaatccc aagtgttctg atcccaagtc catatgtgac 1558201 agcgaatcac caggaggtca atgcgaggtc tcttggccag catgatgcgg cgattgtact 1558261 gaaagaaaca gagctcagcg gggagaagct gattgaagcg ctagaccgga ttgtactgaa 1558321 tgagcaaacg ttaaaggaaa tgagcgaacg aacaaagtca ctcggtgttc ctgacgcggc 1558381 tgcccgttta tacagcgtac tcgaggaatt aaaaaaatag tagaaaagca aatggaatgc 1558441 ggaggtttac gatggagaaa gtgatacagg aattaaaaga acgagaagtc ggcaaggttc 1558501 ttgcaaatga accgctcgcg aatcatacaa cgatgaaaat cggcggacct gcggatgtat 1558561 tggtcattcc aagcagtgtg gatgctgtta aagacatcat ggacgtgatt aaaaaatatg 1558621 atgtgaagtg gacagtcatc ggccgcggat caaatcttct tgttttagat gaaggaatta 1558681 gaggcgtagt gatcaagctg ggggcgggtc ttgaccattt ggagcttgaa ggggaacaag 1558741 taacagtcgg aggcggttat tcggtggtcc gccttgctac atcattgagc aaaaaaggcc 1558801 tgtccggttt ggaatttgct gccggcattc caggatcagt cggcggagcg gtttatatga 1558861 atgccggcgc tcacggttct gatatgagcg agatcctcgt caaagcgcat attttatttg 1558921 aagacggaac gattgagtgg ctgacaaatg agcagatgga tttcagctac aggacatctg 1558981 tactgcaaaa gaaacgcccg ggcgtttgcc ttgaagctgt tttgcagctt gagcagaagg 1559041 ataaggaatc aatcgttcag caaatgcaaa gcaataaaga ctatagaaaa aatacacagc 1559101 cgtattcaag cccttgtgcg ggaagcatat tcagaaatcc gcttccgaat catgccggga 1559161 accttgtaga aaaagcaggc ttgaaaggat atcaaatcgg cggtgcaaag atatcggaga 1559221 tgcacggaaa cttcatcgtc aatgcggggg gagcatcagc aaaagatgtg cttgatctca 1559281 ttgaccatgt gaaaaagaca atccgtgaaa aatacgagat tgatatgcac acagaggttg 1559341 aaatcatcgg cggaaatcgc tgattcaagt tctgactgaa gctgttcata tgatatactg 1559401 taagcaaacg acaaacggca tcatagtatg ccgtttgttt tggaatagac agacttttaa 1559461 cagctgtttc atttgaatga ggtgaacagg caatgaaccc gggtcaagac cgagaaaaaa 1559521 tcgttaacat tgaagagcgg atccctaaaa ttaaagagca gaggaaacaa aaggcaaacc 1559581 gccgtctcat ttcatttatt atgctctttt ttattatggt gctgatcatt gtgtacctgc 1559641 aaacaccaat cagtaaagta tcaacaatct ctgttacagg gaatgaaaat gtatcaaaaa 1559701 aggaaattat cgacctttcc gatattaaca gcggagatac tgagttttgg agtttggaca 1559761 agcaaaaaac agaaaagaag attcagcaaa ataaattagt gaaaaaagcg gagatcagca 1559821 aatcgcttcc taataaaatc aacattgcaa tcgaagaata taaagcgatt gcttatttag 1559881 aaaaagacga tgtgtactat gaagtgcttg aaaacggctc agttctgcca aacgaagtaa 1559941 cgccggatga tgccggaccg attttagtga attggacaaa cgcgaagaag cggtctcaaa 1560001 tggccaagca gctcgatgcg ttgtcaaatt cgttaaaaca gtcgatttca gaaatttatt 1560061 atacgcctgt aaaaatggat gaaaaccgta ttaagttgta catgaacgac ggttatgttg 1560121 ttacggcatc tattaaaacg tttgcagacc gaatgaagac gtatccttct atcatctcac 1560181 agctaagcag caataaaaaa ggaatcattc atttagaagt tgccacctat tttgaagagt 1560241 ttgggaaaaa cgataaagct gctaaaaagg aagatgaaaa ttgaggggca aatcagcagt 1560301 ccttctttcc ttgattatgc ttatcgcagg ttttttgatt tcattttctt ttcaaatgac 1560361 aaaagaaaac aacaaaagcg cggctgagac ggaagagtgg aaaaaagaat atgcgctgag 1560421 agatgaactg ctgaaacaag agaaagaaaa taagaagttt gaaaaagaat tatatcaaaa 1560481 gcaaaacaaa gtccgccagg cggaaaataa gctgaagaaa gagaagtcgg aatactataa 1560541 tgtcctcgaa gatacagaaa aatacaggat gtatattggg gaagtcggtg tgcagggaga 1560601 aggcgttgag gtgacattgg aagatgcgtc atacataccg gaaggggaga atgtgaatag 1560661 ttacatcgtt cacgaaagcc atatcttcca agtagtaaac gaactgtata tctcaggagc 1560721 ggcagctgtc gccgttaatg gacagcgttt gacgcatgat tcgtatatca aatgcaatgg 1560781 tcctgtggta acggtagacg gggtgcagca tcccgctccg tttacggtat ccgctattgg 1560841 agatccagat gtcctgctgc cctcgttaaa tatcgctgga ggcctaattg atcagctgtc 1560901 aatggatcat atttctgtgt cggcagaaaa agagaaaaac gtacaaatga aaccgattct 1560961 gaaaacgaag gaatgactga aaaagcgggt gaaatagatt gaaaataaag cgttccttca 1561021 taagcatcag tgttcttatg gtcatcttcg gcctgatgat atctgttcag tttaattcgt 1561081 taaagcaccc caaagtccgg gatacaagag atatgtggga tattagggaa gagctgacat 1561141 cagagcagaa gaagcaggaa aagctgctgg ctgaaataaa caaatatgac aaattgctga 1561201 atagctattc gcaaacgaaa gaaatgacaa aagaaaccgc gctaaataat accttgcaat 1561261 ccttaaaaaa aacagccggc atgaccgata taacaggtag cggaattgtc attacgattt 1561321 ccccgctttt ttctgaaagc ttaacaggag agccgatcga aaatccgcct ccggatttgc 1561381 tgaaaaagct gataaatgaa ctcaactcct acggtgcaga gcatatctcg attaatgagc 1561441 gaagagttgt gaatcataca gtcatcagag atataaacgg cactacaaaa atagacggat 1561501 acgcccttga cgattatcct ttaacagtaa aagtgcttgc caaagatccg gacatgttac 1561561 acagcagagt gaaggggtca ggccttgagg atctttttgc atctgaaaat ttagcattaa 1561621 aagccggtaa atctgaaagc aaactaacat taaaagcata tgacagacca ctggacgtac 1561681 aacagctgaa actgcttaaa gactgaaaag gaggagaatt gtcatgtggc tgcccgtgtt 1561741 gggactggtg ctcggaatag cgattggact aatgacaaac ttaacgatac cgagtgaata 1561801 ctcaaactat ttatcgcttg cggtgcttgc cgcacttgat acattaatcg gcggaatcag 1561861 ggcgcattta caaggtacat atgatgaaat ggtatttgtt tccggtttct tttttaatat 1561921 tatattggca ataagtttag cttttctggg agtccatctt ggtgtagact tgtatttagc 1561981 aggtatattc gcatttggag tcagattatt tcagaatata gccgttatca gaagaaatct 1562041 actaacaaag tggactcttt ctaaaaaaaa taaaaaaaat gtgatataaa agaggatata 1562101 cataggatat aacgaatatt ttcaataaac ataaaatgtg aaaagcacat aaaaatattc 1562161 tgttgttatt ttttgttaca cacttgtaaa gccacattca ttgtattgtt gttccgcaaa 1562221 taatagaata gaaatgatcg aaatgtgagg aggtgccata gaatgaacaa caatgaactt 1562281 tacgtcagtc ttgacatcgg tacgtccaat acaaaagtga tcgtcggaga aatgacagat 1562341 gattccctta atattatcgg tgtgggaaat gtaccgtctg aagggttgaa aaaaggctca 1562401 atcgttgata tagatgagac cgttcattct ataagaaaag cgtttgacca agctgaaaga 1562461 atggtaggtt ttccgcttag aaaagctatt gtcggcgtta atggaaatta tatcaatatt 1562521 caagatacaa acggtgttgt agcagtttcc agtgaaaata aagaaattca ggttgaagat 1562581 gtacgccgtg tcatggaggc ggcacaggtt gtttccgtac cgcatgaaca gctgattgtt 1562641 gacgtcattc ctaaacagtt tatcgtagat ggaagagatg aaatcaccga cccgaaaaaa 1562701 atgctgggtg tgcgtttaga agtagagggc accttgatca ccggttcaaa aacaatctta 1562761 cataacttac tccgctgcgt tgaaagagct ggtattgaaa taactgatat ttgccttcag 1562821 ccgctggcag ccggttctgc tgcattatca aaggacgaga aaaaccttgg tgtggctctc 1562881 attgatatag ggggagggtc aacaaccatt gccgtattcc agaacggaca tctcacttct 1562941 acccgtgtca ttcctctcgg aggcgaaaat atcaccaaag atatctccat cggattgaga 1563001 acgtcaacag aagaagcaga acgcgtgaaa aagcaacttg gacatgccta ctatgacgaa 1563061 gcctcggaag atgaaatatt tgaggtaacc gttataggca ccaatcaaaa acaaacattt 1563121 acacagcaag aagcagcgaa tatcattgaa gcgagagtag aggaaattct tgaaattgtt 1563181 tcagaagagc ttcgcagtat gggaattacc gatctgccgg gaggcttcgt gctgacagga 1563241 ggacaagcag ctatgccggg tgtcatgtct ttggcacagg atgtgctgca aaacaatgtc 1563301 agagtggcaa gcccgaatta tatcggtgta agagatcctc aatatatgac gggagtgggc 1563361 ctgatccaat tcgcctgccg gaatgcaaga atccaaggca gaaaaatagg ctttaagatg 1563421 cctgaagaag cgatacagga aatcgcagtc tcatcatctg aggaacaaga gcagcatcat 1563481 caccaaaatg aggtgcagca gcggccaaaa ggaaaacaaa aaacacaagc cgaacataat 1563541 aaacagagca aaatgaaaaa actattaagc atgttttggg aatagataga tagtcattcg 1563601 gcagattagg aggatttagc atgttggagt tcgaaacaaa catagacggc ttagcatcaa 1563661 ttaaagtaat cggagtagga ggcggcggta acaacgccgt taaccgaatg attgaaaatg 1563721 aagtgcaagg agtagagtat atcgcggtaa acacggacgc tcaagctctt aacctgtcaa 1563781 aagcagaagt gaaaatgcaa atcggcgcaa agctgactag aggattggga gcaggtgcga 1563841 atccggaagt cgggaaaaaa gccgctgaag aaagcaaaga gcagattgaa gaagcactta 1563901 aaggtgctga catggtattc gtgacagctg gtatgggcgg cggaacagga acaggtgccg 1563961 caccggttat cgcacaaatc gcgaaagact taggcgcatt aacagtcggc gttgtgacaa 1564021 gaccgtttac cttcgaagga cgcaaaagac agcttcaggc tgcaggcgga atctcggcaa 1564081 tgaaagaagc ggtggataca ctgatcgtga tcccgaacga ccgtatcctt gaaattgttg 1564141 ataaaaacac accgatgctt gaagcattcc gcgaagcgga taacgtactt cgccaagggg 1564201 ttcaaggtat ttctgacttg attgctacac ctggtcttat caaccttgac tttgctgatg 1564261 tgaaaacaat catgtcaaac aaaggatctg ctttgatggg tatcggtatt gctactgggg 1564321 aaaatcgcgc ggcagaggca gcaaaaaaag caatttccag cccgcttctt gaagcggcca 1564381 ttgacggtgc gcaaggcgtc ctcatgaaca tcactggagg aacaaacctc agcctatatg 1564441 aggttcagga agcagcagac attgtcgctt cggcgtctga tcaagacgta aacatgattt 1564501 tcggttctgt tattaatgaa aatctaaaag atgagattgt ggtgacagtg attgcaaccg 1564561 gctttatcga acaagagaag gacgtgacga agcctcagcg tccaagctta aatcaaagca 1564621 tcaaaacaca caatcaaagt gttccgaagc gtgagccaaa acgtgaggaa cctcagcagc 1564681 agaacacagt aagccgtcat acttcacagc cggctgatga tacgcttgac atcccgacat 1564741 tcttaagaaa ccgtaataaa cgcggctaat gtaaaggaca aaatcgtttt cgattttgtc 1564801 cttttttgtt tttctcttca cactttcctt cttataaagt ctttttccct attgcttcct 1564861 tcgcttagta acaaaacaga taattagacc catttatttt tgtgacattt ttatcatttt 1564921 catatatatg gaaattgaat gacatgaaac gacaatatct gtaattcaga ttgtctacag 1564981 ttaatataca gcgatgttct gacaaaccat tcattattaa aaggagggac gacacttttt 1565041 ttaaaaagca tgttgaaaaa gggggatgaa aatgaggaaa aaaacgaaaa acagactcat 1565101 cagctctgtt ttaagtacag ttgtcatcag ttcactgctg tttccgggag cagccggggc 1565161 aagcagtaaa gtcacctcac cttctgttaa aaaggagctt caatctgcgg aatccattca 1565221 aaacaagatt tcgagttcat taaagaaaag ctttaaaaag aaagaaaaaa cgacttttct 1565281 gattaaattt aaagatctgg ctaacccaga aaaagcggca aaagcggctg ttaaaaaagc 1565341 gaaatcgaag aagctgtctg ccgctaagac ggaatatcaa aagcgttctg ctgttgtgtc 1565401 atctttaaaa gtcacagccg atgaatccca gcaagatgtc ctaaaatact tgaacaccca 1565461 gaaagataaa ggaaatgcag accaaattca ttcttattat gtggtgaacg ggattgctgt 1565521 tcatgcctca aaagaggtta tggaaaaagt ggtgcagttt cccgaagtgg aaaaggtgct 1565581 tcctaatgag aaacggcagc tttttaagtc atcctcccca tttaatatga aaaaagcaca 1565641 gaaagctatt aaagcaactg acggtgtgga atggaatgta gaccaaatcg atgccccaaa 1565701 agcttgggca cttggatatg atggaactgg cacggttgtt gcgtccattg ataccggggt 1565761 ggaatggaat catccggcat taaaagagaa atatcgcgga tataatccgg aaaatcctaa 1565821 tgagcctgaa aatgaaatga actggtatga tgccgtagca ggcgaggcaa gcccttatga 1565881 tgatttggct catggaaccc acgtgacagg cacgatggtg ggctctgaac ctgatggaac 1565941 aaatcaaatc ggtgtagcac ctggcgcaaa atggattgct gttaaagcgt tctctgaaga 1566001 tggcggcact gatgctgaca ttttggaagc tggtgaatgg gttttagcac caaaggacgc 1566061 ggaaggaaat ccccacccgg aaatggctcc tgatgttgtc aataactcat ggggaggggg 1566121 ctctggactt gatgaatggt acagagacat ggtcaatgcc tggcgtgcgg ccgatatttt 1566181 ccctgagttt tcagcgggga atacggatct ctttattccc ggcgggcctg gttctatcgc 1566241 aaatccggca aactatccag aatcgtttgc aactggagcg actgatatca ataaaaagct 1566301 cgctgacttt tctcttcaag ggccatctcc atatgatgaa ataaagccgg aaatatctgc 1566361 accgggcgtt aatattcgtt catccgttcc cggtcagaca tatgaggatg gttgggacgg 1566421 cacatcaatg gcagggccgc atgtatccgc tgttgctgca ctgctgaaac aggcgaatgc 1566481 ctcactttct gttgatgaga tggaggatat attaaccagc acggctgaac cgctcacgga 1566541 ttcaacattt cctgattcac cgaataacgg atatggccat ggtctggtga atgcttttga 1566601 tgctgtatcc gctgttacag atggattagg gaaagcggaa ggacaagttt ctgtagaggg 1566661 ggatgaccaa gagcctcctg tctatcagca tgagaaagta actgaagctt atgaaggtgg 1566721 cagcctacca ctgactttga cagctgaaga caatgtgagt gtgacatctg taaagctgtc 1566781 ctacaagctt gatcaaggtg aatggacaga aataacggct aaacgaatca gcggtgatca 1566841 tctaaaagga acgtatcagg cagagatccc agatataaaa ggaactaaac taagctataa 1566901 gtggatgatt cacgattttg gcggtcatgt cgtttcgtct gacgtatacg atgtaacagt 1566961 gaaaccaagc atcacggcgg gatataagca ggactttgaa actgcacccg gcggctgggt 1567021 tgcgagcgga acaaataata actgggaatg gggagttccg tcaactggcc caaatacagc 1567081 agcatccgga gaaaaagtat atggaacgaa tttgacagga aattatgcca actcagcaaa 1567141 catgaacctt gttatgcctc ctattaaagc acctgattca ggaagtctgt tccttcaatt 1567201 taaaagctgg cacaatttag aggatgattt tgattacggc tacgtttttg ttcttccgga 1567261 aggtgaaaag aattgggagc aggctggtgt ctataacgga aagacatcaa gctggacgga 1567321 cgaagaaatt gatttatcgg cttataaagg ccaaaacatt caagtgatgt ttaaccttca 1567381 atctgatgaa agcattgcaa aagagggctg gtatattgat gatgtagtgc tttctgacaa 1567441 atcagccgga aaaacagtca aaaagaataa gctgggcgtc gaaaagccgt ctggaaagca 1567501 aaagaaaaag ccagtaaatc cgaaaaaggc taagccatct gcaaacacag cggtaaaaca 1567561 tcagaacaag gctatacagc ctcaagtttt gccgctcaag gcacaagtca gtgtagtgga 1567621 aacaggaaaa tcaacatatt cagatcaatc cacagggcag tacacgctga agcacaaagc 1567681 gggagactat acgcttatgg cagaagcata tggttatcag tcgaaaacac aaaaagtatc 1567741 tttaaagacg gatcagacga cacaagctaa ttttacgtta gaagagatga agaagggcac 1567801 attaaaaggc acggtcatca ataaaacgac aggagagccg gtaacaggcg cttccgttta 1567861 tgttgtagag gatgctgcgg tggaaccggc tatgacaaac gacaaaggtg aatatatgct 1567921 ggaggcctat gaaggcgctt atacgattaa agtcgctgca ccgggttatt acagtgatga 1567981 attttccgtt gagttaaaag gtgatgttac aaaagaaact gcattgaagc ctttcgtcgg 1568041 ttatccgggt gaaattgcat atgatgacgg aacagcggag aatgccaatt cctattttgc 1568101 tgccggtaac ggatgggcgg taaaaatgac gctcgctgac ggcaaggaca aaggcatgct 1568161 tacaggaggg ctgttcagat tctgggatac agagttccct gatccgggcg gcacagagtt 1568221 taaggttgag gtatacgatg ccacaggaaa agacggagca ccgggcaaga aaattgcagg 1568281 gccatttaac gcggaagctc ttcgcaatgg cgagtggact aaggtagatc tcagttcaaa 1568341 agggattatg gtcgataaag atttttatct cgtatatatc cagtcgaaac ctgatccgta 1568401 ttcacctgga ttggcaatgg atgaaaccgg ccagaattcc ggccgcaact ggcagtatat 1568461 agatggaaag tggcagccag gtgacaaagc ggatggcaac tatatgattc gcgcattagt 1568521 tgattatgaa gctgctgtac ctgagattac ttcaccgaca gacaaatcat acacaaataa 1568581 ggatagcgtc actgtaaaag gaaacgcttc tcctggcaca acggtacaca tttataatgg 1568641 agagaaagaa gcaggagaaa cgaaagctgc tgcggatggc acgttccatg caggcatcat 1568701 actcaacaag ggtgaaaatg agctgacggc aactgcatca actgacaacg gaacaacaga 1568761 tgcctccagc ccaatcacgg tcacgcttga tcaagaaaag cctgaattaa cactggacaa 1568821 tccaaaggat ggcgggaaaa caaataaaga aacgctgact gtcaaagggg ctgtatccga 1568881 tgacaatctg aaagacgtca aggtgaatgg caaaaaagca acagtagctg atggttcata 1568941 ctcagcccgt attcttttgg aaaatggaag aaatgaaatc aaggtaattg ctacagactt 1569001 ggcaggcaac aaaacgacga aaaagacagt cattgatgtg aactttgaca agcctgtcat 1569061 ttccggctta attccgggag aggataaaaa cttaaaagcc ggtgaatctg tgaaaatcgc 1569121 tttctcaagc gctgaggatt tagatgcaac gtttaccatt cgtatgccgc tgaccaatgc 1569181 aagagcgagt gtgcaaaatg ccaccgaact cccgttaaga gaaatctctc cggggagata 1569241 tgaaggctat tggactgcca cttcttctat taaagcaaaa ggagcaaaag tagaagtgat 1569301 cgtccgagat gattatggaa atgaaacaag aaaaactgcg aatggaaaac ttaatatgaa 1569361 cacagaaaat taagtggaaa aaaagctgcc gtcattggca gcttttttta tatcctctca 1569421 ttatacttcc tcgacaaatt aagcagattt ccctgaaaaa ttgtattttc ctctcaacat 1569481 taattgacag actttcccac agagcttgct ttatacttat gaagcaagaa ggggaacagc 1569541 gtgaggcaag aaagaaagga gtcagatgtg aaaatctatt tagatgtcat ttggctgtta 1569601 aacttttgtt ttgatgcact tttgcttttg ctcacggcat ttattttaaa acggcatgta 1569661 aaaaaaagaa gactggtagg cggagcgttc atcggttcca gtattgtcct tttgatgttt 1569721 actccttttt cgccgattgt tgaacatccg gctgggaagc tagctttttc agttgtgatt 1569781 gtggtggtga catttggctt taaaagattt cggtttttct ttcaaaattt gttttccttt 1569841 tattttgcca cttttttaat ggggggagga attatcggag cccattcttt gctgcagtca 1569901 aattctattg ttcaaaacgg tgtcatgatt accaatcaaa cagggtttgg agacccgatc 1569961 agctggttgt ttattgttgg tggctttcca gcattatggt ttttttctaa aagaagaatt 1570021 gaagatattg aaacaaaaaa cattcaatat gaggaacgag tcagcgtgca ggcagatttg 1570081 ggcagccaaa cacttcatgt cagaggcctg attgattccg gtaaccagct gtacgatcct 1570141 cttacaaaaa caccggtaat gatcatttac attgataaac tggagccgat tttcggaaca 1570201 gccgaaacga tgatcattcg aaacacagac ccattggaag ccatcgaaca gctcgatgat 1570261 tcctttcgct ttttagataa aatgaggttg attccataca ggggagttgg tcagcaaaat 1570321 caatttttat tatgcgttaa accggatcac gtaacgatta tgacaaaaga agaaatgatt 1570381 tctgcagata aatgtttaat cggtatcagc acaacaaagc tgtcggcaga tggagagttt 1570441 gacgcgatta ttcatccgaa aatgctttcg ggcaaggctg tcaaacacgt ttcataatgt 1570501 tcgcaaatgt ccgttactta tcatactcaa acggcgtgac atttagaagg gagaggaaga 1570561 tgaaaaaact gaaattacgg ttgacgcacc tctggtataa gctgctgatg aaacttgggc 1570621 tgaaaagtga tgaagtctat tacataggcg ggagtgaagc cctgccgcct ccattatcta 1570681 aagatgagga gcaggttttg ttaatgaagc tcccaaacgg cgatcaggcg gcgcgcgcca 1570741 ttctaattga acgcaatttg cgtctggtcg tatatatcgc ccgtaaattt gaaaatacgg 1570801 gaattaatat agaggattta atcagcatcg gtaccatcgg tctaatcaaa gctgttaata 1570861 catttaatcc agaaaagaaa atcaagcttg ctacctatgc ctcccggtgt atagaaaatg 1570921 aaatcctgat gtatttaaga agaaataaca aaatccgttc agaggtttcc tttgatgaac 1570981 cgcttaatat tgattgggac ggcaatgagc ttttgctttc tgatgtgctc ggcactgacg 1571041 atgacatcat cactaaagac atagaagcta acgtcgataa aaagcttttg aaaaaagcgc 1571101 ttgaacagct taatgagaga gaaaagcaaa tcatggagct gcggtttggg cttgtcggtg 1571161 aagaagaaaa aacccaaaag gatgtagcgg atatgatggg gatttctcag tcttatattt 1571221 cgcggcttga gaaaagaatt ataaaaaggt tgagaaaaga gttcaacaaa atggtgtaaa 1571281 aaattttatg gttagaaccc cttgatttta cagggatttc ctgatttcga cagtttttcg 1571341 gtctgagtgc agtgcatatt tttcccaccc aaggagatac ttaacgttgt acagcagctc 1571401 ctgtagggag ggaaaaaagt gtcgagaaat aaagtcgaaa tctgcggggt ggatacctcc 1571461 aaattaccag tactcaagaa tgaagagatg agaaagctgt ttaggcagct gcaggatgaa 1571521 ggcgatgatt cagcaagaga aaagcttgta aacgggaact tgcgtcttgt cttaagtgtc 1571581 attcaacgat ttaataacag aggggagtat gttgatgact tatttcaagt cggctgcatc 1571641 ggactaatga aatccattga taattttgac ctaagccaca atgttaagtt ttcaacatac 1571701 gctgtaccta tgattatcgg agagatccgc aggtatttac gtgataataa cccgatccgt 1571761 gtctcaagat cactccggga catcgcttac aaggcgcttc aggtaagaga gcggttaatc 1571821 agtgagacaa gcaaggagcc gactgcagaa gacatcgcaa aagttcttga agtaccgcat 1571881 gaggaaattg tatttgcgct tgatgccatt caggatccgg tttctctatt tgaaccgatc 1571941 tataacgacg gcggagaccc gatctatgtg atggaccaaa tcagtgatga gcgtaataca 1572001 gattcacaat ggattgaaga gctggcttta aaagagggca tgagaaggct gaacgatagg 1572061 gaaaaaatga ttttgagaaa gcgattcttc caagggaaaa cccaaatgga agtcgccgag 1572121 gaaatcggaa tttctcaagc gcaggtgtcc agacttgaaa aagcggctat caaacaaatg 1572181 aataaaaata ttcatcaata atgaaaagcc tttaaaacga tgttgtttta aaggcttttc 1572241 tattgattat ggatggttta cgttttggaa aaagtaaggt atcctagttc gtacaaagtt 1572301 ttatgaaaat taaaacaatt ataaaaggca ataaagagga ggaccacgat gattttgcag 1572361 cttgacaatg tctcactaaa acggaatggg aaatggatac tgaaagatat tcattggaag 1572421 gtggaagaaa aggaaaattg ggtgctttac ggcctaaatg gcgccgggaa gacagcgctg 1572481 ttaaatatgc tttgctcata ttattttcca acatcaggcg agatgcaggt gctcggccat 1572541 gaatttggca aaacagagct tggggaaaag ctcagacgta aaattggcct cgtctcagca 1572601 gctcttcagc aaaaattgta tccggcagat tcagcttttg aaattgcttt gagcggagct 1572661 tacgcttcga ttgggttata tgaaacgcca agtaaggaaa ccagggaaaa agcgataggt 1572721 ttgttagagg acttgggagc aattgaatat gccgatcgcc gctatgaaac cctttctcaa 1572781 ggggaaaaac aaagagcatt gattgctaga gcactaatgg ccgatccgga gctgctgata 1572841 ctggatgaac cagtcacagg actggatttt attgcccggg aaaagctgtt agatacgatt 1572901 acatacattg caaacaaaga aaatgcacca tctatccttt atgtgactca tcatgctgaa 1572961 gaaattttgc ctgtctttga taaagccctt ttattaaaac agggagaggt ttttggatcc 1573021 ggagaaataa aggaaatgct tactgatcaa atactttccg ctttttttga tacgccaatc 1573081 catgtattat ggaatcagga tcggccgttt ttaacaagag ctgagccgat aacgaatgcc 1573141 tgacaaatat atatagattc atcctagggg tgctttgcga agctgagaga gactttgtct 1573201 caaccctttt gacctgatct ggatcatgcc agcggaggga agcggtgaaa agcggagtac 1573261 atcggactcc gtttgttttt attaagccgt ttcatcacat ttgaaacggc ttttttgatt 1573321 ttaaagaata ggagcggatt tacattggat caacaaatat actctttgca aaaaaaagtg 1573381 gaagaacata aggaggagct tattcagctt gcgaaaacgc tgatttctta tcaaacacct 1573441 gctccgcctg caagaaatac agagggcatt cagtcttgga ttgcgggata tttaaatgaa 1573501 ttgggattct cgatcgacaa atgggatgtg taccctggag atcccaatgt tgtagggaag 1573561 ctaaaaggaa cagattcagc agattattat agcctgatta tcaatggcca tgtagatgtg 1573621 gcagaggtaa aagaggatga agaatggaag cacgatccgt ttcatcccat tgaaaaaaac 1573681 ggtctcttaa tcgggcgagg cgcttccgat atgaagggcg gaatggcttg tgtgctgttt 1573741 gctgtcaaat taattcgtga agcaagcatt gaacttccag gtgatctgat tctgcaatcg 1573801 gttattgggg aggaagttgg agaggccggc acacttgaat gctgcaagag gggctaccac 1573861 gctgattttg caattgtcgc ggatacgagc gatatgcata ttcaaggcca aggcggtgtc 1573921 attacaggct ggatcgaaat caaaagcagt caaacatttc atgatggaac gagacggaat 1573981 atgattcatg caggcggagg aacattcgga gcaagcgcaa ttgaaaaaat ggcaaaaatc 1574041 attgcggggc tcggtgaact tgagcgccac tggtctatta tgaaaagtta tcccggtttt 1574101 aaaccaggca caaatacgat taacccggca gttatagaag gcggcagaca tgcggctttt 1574161 atagcggacg aatgccggct gtggatcaca gtccattttt atccgaatga aacccatgac 1574221 caagtggcag cggaaataga agattacgtc aatcggctga gtgacagtga tatttggctt 1574281 agggaaaacc gccctgtatt caagtgggga ggctcatcta tgatagaaga caggggagaa 1574341 atttttccgg cattggaagt tgaccctggc cacccaggcg tcttagcgct aactgcctct 1574401 catcagaaag tgaaacggga gtgtccaatt attgacgttt ctcaatcagt tacagatggc 1574461 ggatggctgt atgatgccgg tattccatgc gtaatatacg gtcctggaga tctgcacaat 1574521 gcacactctg tgaacgagaa ggtatcgatt gagcagctag tagagtatac aaaaattata 1574581 ctcgatttta tcatcagctg gtgcagccgg aaaaaagaac aatgacatga aaatttcttc 1574641 ttgctgacaa ggttcagcct gcccgttcat atacttgaac aaaaggacgg aaaaaggacg 1574701 tgatggaatg atcagcattt cagaatttca ggtaaaggat gtcgtcaatg tctcaaacgg 1574761 aaaaaagctg gggagtattg gtgatattga tatcaatgtg accactggaa aaattcaggc 1574821 gatcatactc ggaggaaatg ggaaagttct cggatttttt ggaaaagaag aggaattggt 1574881 cattccatgg cgaaatatag taaaaatcgg ggaagatgta atcttagtcc gattaagtga 1574941 accacatgca taaacctgct tgtctgccgc agattggcaa atgccggaag tctcgattct 1575001 tccggcacat ttcatttaga aatatgcaaa tcggcgctca acgaatgcag taagatgtgg 1575061 taaaataagt gggaaattcc gcttttttaa atgtttgtcg aaaggttgga tcatcatgaa 1575121 tacatatcac ccattcagtc ttaccacacc ctcgacactc atgatacaag actgggctca 1575181 aacgaatcaa aacaacaaag aggtcattgc cggatttacg acaaaaaacg gcggtgtcag 1575241 ccaaaagcct tttgaatcgt taaatacagg attgcacgtt catgacaaag atgcagatgt 1575301 agttaaaaat cgtgaatata ttgccgatat gtttaatact gatttgcagt cttgggtatt 1575361 cgctgatcag acacatgata atcgcgttca gaaagtgacg cagagggata ggggaaaagg 1575421 cgcccgtgag tatcacacgg ctctaaaagc aacggacggg atctatacaa atgaaaaaaa 1575481 tgtattttta gcattatgct ttgctgattg tgtgcctctt ttcttttatg atccggttaa 1575541 gtcgcttgtc ggagtcgccc atgccgggtg gaaaggcacc gtcaaacaga ttggcagaga 1575601 aatggtgaag caatggactg agaaggaagg ttcaaatccc tcagatattt acgctgttat 1575661 tggcccgtct atcagcggag catgctatac ggtagacgac cgcgtcatgg atgctgtccg 1575721 cgcattgccg gtttcagcag accttgccgc caatcagacg gcaaaggcac aatatcagct 1575781 tgatctgaaa gagctgaacc gtcttatact gatggacagc ggtttggcaa gtgaacaaat 1575841 ttctgtcagc ggtttatgca cggaaagcga gccgtctctt ttctattctc atcgccgcga 1575901 tcaggggaaa actggacgga tgatgtcctt tatcggaatg aaggaggcat aaaagatctt 1575961 gcgtgttgtt gataatttac gacatataaa cgaacgaata aacgaagcat gtaacagatc 1576021 gggccgcagc tccgatgaag ttacggttat tgcagtcaca aaatatgtat cacctgaaag 1576081 agcacaggag gcagtagatg ctggcatcac ctgcctcgga gagaatcggg atgcggaact 1576141 gctccgcaaa caggaattga tgaaagggaa tccggaatgg cattttatcg gcagtctgca 1576201 atcaagaaaa gcaaaatctg tcgtcaattc ggtttcctat atccattccc tagaccggct 1576261 ctcattagcg aaagaaattg aaaaacgggc tgaaggtact gtacgatgct ttgtgcaggt 1576321 caatacctct cttgagcctt ctaaacatgg catgaaaaaa gaagaagtca ttccattcat 1576381 acaggagctt tccggtttcg aacatatcct tgttgccggg ctgatgacaa tggctccgct 1576441 gactgatgat caagatcaga tcagaagctg tttcaggtcg ctgagagaac tccgtgacca 1576501 ggttcagaag ctgaaccagc cgaacgctcc gtgtactgaa ctgtcgatgg gcatgtcaaa 1576561 tgattttgaa attgcaattg aagaaggagc tacttatatt agaatcggct catcgttagt 1576621 cggaaatgaa acagggggtg tacagcaatg agtatgaaaa ataaactgaa aaactttttc 1576681 tcaatggaag atgaagaata cgaatatgaa tatattgaga cagagcggga atctcatgag 1576741 gagcatgagc aaaaagaaaa gccggcttac aacgggaata aacctgcggg caaacagaat 1576801 gtagtgagct tgcaaagtgt tcagaaatcc tctaaagtgg tgttgagtga gccgcgcgtt 1576861 tatgcggagg cgcaggaaat agccgaccat ttgaagaacc ggcgggcagt tgtcgtcaat 1576921 cttcagcgga tacagcatga ccaggcgaag cggattgttg actttttaag cggaaccgtt 1576981 tatgccattg gcggcgatat tcaaagaatc ggctcagata ttttcctctg cacgcctgac 1577041 aacgtagatg tatcaggcac aatttctgag ctcatatctg aagacgaaca tcagaggtgg 1577101 taaagcgaga tgatccttta tcaagttttt tcggttttaa gcttattaat cacaatatac 1577161 tcatttgccc tgatcatata tatttttatg tcatgggtgc cgagtacgag ggaaacagca 1577221 gtcgggcgtt ttttggcttc gatttgtgaa ccatatctcg aaccattcag aaaaatcatc 1577281 cctccgattg caatgctgga tatttcacca atcgtagcaa tacttgtgct tcggtttgcg 1577341 acaaccggct tgtggggact ttatcgcatg attgcgtttt aatgtgacag tttgataggg 1577401 gcttggcagc agccaagcct ctttacatag aagggaaaga cgatgagcga tatatatcag 1577461 cacttcagaa aagacgagcg ggcctttatt gatcaagcgc tcgaatggaa aagaattgtc 1577521 caggagcagt accggatgaa gctgaccgac tttttagatc cccgagagca ggtcatcctc 1577581 tctgctgtta cgggacaggc agatgtcggg cttgcctttt ccggcggcta tgacagagcg 1577641 gagcggaaac gggcgattct gtttccagag tacattactc cggaagaatc agattttgaa 1577701 ctgcaggcgt ttaacgtccg ttatgctgac aagtttgtct cagtagatca tcgttctctg 1577761 cttggtgcat taatgggcat aggattaaag cggcaaaaat tcggtgacat cgtgttttct 1577821 gagacagcag tgcaattgat tgtctcagcc gataccgctg attttgtggc tgcacagctg 1577881 acccaagcag gcaaagcggc ggtcagccta gagaaaatcg acttgtcaga ccttaacatt 1577941 ccagcagttg atgtcgaaat aagagatgac acggtttctt ctttaaggct tgacgccgtc 1578001 tgcgcctcta tgagcaggca atcccgccag aaatcacaga cgcttgtgaa aaacggcctt 1578061 gtgaaagtga actggaaggt ggttgaagat ccttcataca tagtcgcgga aggggacatg 1578121 ctgtctatca gaggttttgg ccggtgcagc ttaacaaaaa tcgaaggaaa aaccaaaaaa 1578181 gacaaatgga gagttacgtt tgaacgacaa aaatagtcgg tttttcagtt tttttctcca 1578241 tctgtgcgaa atttgtttta taatgtgaac tagataaccg tactgaaatg taaaaatgga 1578301 ggtggcatca tgccattaac gccaaatgat attcacaaca agacgtttac aaaaagtttt 1578361 cgcggatatg atgaagatga agtaaatgaa ttcctagccc aagtcagaaa agattacgaa 1578421 attgttctcc gcaagaaaac tgagcttgaa gcgaaagtca atgagcttga tgaaagaatc 1578481 ggacactttg ccaatattga ggagacattg aataaatcaa ttttagttgc tcaagaagcg 1578541 gctgaagacg taaaacgcaa ttctcaaaaa gaagcaaagc tgatcgttcg ggaagcggag 1578601 aaaaacgctg atcgcattat caacgaatcg ttatcaaaat caagaaaaat tgcaatggaa 1578661 attgaagagc tgaaaaaaca gtctaaagtg ttcagaacac gtttccaaat gctgattgaa 1578721 gctcagcttg atcttctgaa aaatgacgat tgggatcatc tccttgagta tgaagtcgac 1578781 gctgtatttg aggaaaagga ataaattctc tgattatctt gacattttct tagcttgtcg 1578841 aatataatac gttcataaat tcagatgaaa aaacggttga aagggacagt catgtttcct 1578901 tcaggccttc atagcgaccc ggagatggtg agagtccggg atggccggaa tcatgtagat 1578961 cagcccttta gtttccttgc tgaactcaca gtaggttagg acgttcatca cgttacgatg 1579021 ctcaagagga aaaagtgtat gcttgctttt tctaaaaggg tggtaccgcg agataagctt 1579081 tctcgtccct tatgggatga gagggctttt tttattttct gaaaaaatgc agtggaggaa 1579141 tgaaaatgga ttttaaagac acgctcttaa tgccgaaaac agatttcccg atgcgtggaa 1579201 atttgccaaa ccgtgagcct gacattcaaa aaaaatggga ggaagaagat atctaccgtc 1579261 ttgttcagga acggacgaaa gaccgcccga aatttgtttt acatgacgga cctccgtatg 1579321 caaacggcga catccatatg ggccatgcac ttaacaagat tttgaaagac ttcattgtcc 1579381 gctataaatc aatgagcggc tacaacgcac cgtatgtgcc gggctgggat acacacggat 1579441 tgccaattga aacagctctg acaaaaaaca aaaaggtcaa ccgcaaagaa atgtcagtag 1579501 cggaattccg caaactatgc gaagagtacg cttggaagca aatcgaggga cagcgtgagc 1579561 aattcaaacg tcttggtgtc cgcggtgact gggaaaaccc atatgtgaca ttaaaaccgg 1579621 aatacgaagc gcagcaaatc cgcgtatttg gtgaaatggc aaaacgaggc tacatttaca 1579681 aaggccttaa accggttaac tggtcacctt caagtgagtc tgctctggct gaagccgaga 1579741 tcgaatatca agataaacgt tcagcatcta tttacgtcgc ttttggtgta aaagacggaa 1579801 aaggcgttct tgaaaacggc gagcgcatca tcatttggac aacaacgccg tggacaattc 1579861 cggcgaacct cggaatctca gtgcaccctg atcttgagta cagcgtgatt gcagtaggtg 1579921 aagaccgctt tgttgtagca agtgccttag tcgaaaatgt tgcatcggca tgcggatttg 1579981 atcagtatga agtgacaaga acggtcaaag ggaaagacct tgagaacatt atcgctgaac 1580041 acccgctata tggcagagac tctctcgtta tgcttggtga acacgtaaca actgatgccg 1580101 gaacaggctg tgttcataca gcgcctggac atggggaaga tgactttatc atcggccaaa 1580161 aatacggttt agatgtgctt tgcccggtcg atgaaaaagg tgtaatgaca agcgaagctc 1580221 ctggctttga aggcatgttc tatgatgatg caaacaaagc gatcacacag cagcttgatg 1580281 aaaaaggcgc acttgtgaag cttgaattca ttactcattc ttatccgcat gattggagaa 1580341 caaaaaaacc aaccattttc agagcaacag cgcaatggtt tgcgtctatt aaagatttca 1580401 gatcagacct gctggatgcc attaaagaaa ccaaatgggt tcctgaatgg ggcgagcagc 1580461 gtttgcacaa catggttcgg gaccgcggag actggtgtat ttccagacag cgtgcgtggg 1580521 gtgtgccgat tccggtattt tacgctgaaa acggagaacc ggttattaca gatgaaacca 1580581 ttgaacatgt ttctgaattg ttcagacagc atggatcaaa catttggttt gaaaaagaag 1580641 caaaggatct tcttccggaa ggctttacgc atcctggcag cccgaacggc acatttacaa 1580701 aagaacagga tatcatggat gtttggtttg attcaggctc ttcacatcaa gcagtgcttg 1580761 aagaacgtga tgacctcgtt cgcccggctg atctatacct agagggatct gaccaatatc 1580821 gcggctggtt taactcttct ctttctacag cagtagccgt aacagggaaa gcgccgtata 1580881 aaggtgtgct cagccatggg ttcgcactgg atggagaagg acgtaagatg agtaaatcaa 1580941 tcggtaacgt tgttgttccg gctaaagtca tgaaacagct tggtgccgac atcttaagat 1581001 tatgggtatc ttcagtggat tatcaggcgg acgttcgcgt gtctgacgcc attctgaagc 1581061 aggttgcgga agtatatcgt aaaatccgca acacgttccg tttccttcac ggcaaccttt 1581121 tcgattttga tccaaaaaca aatgcggtgg ctgtcgaaga tcttcgcgaa gtggatcagt 1581181 atatgctgat taagctgaac aagctgattg ataaagtgaa aaaagcgtat gatgagtacg 1581241 aatttgcggt tgtgtatcac agcattcata atttctgcac aatcgaattg agctcattct 1581301 accttgattt tgcaaaagat attgtctaca tcgagcatgc ggatcatccg gatagacgca 1581361 gcatgcagac agtattctac gaaacgcttc ttgcattagt gaagctttca gcgcctatcc 1581421 ttccacatac ggcagacgaa ttgtggtctc atttaacatt tgttgaagag cagagcgttc 1581481 agttgaccga tatgccggaa acaatcacgg ttccaaacag tgaagcgact gaagaaaaat 1581541 ttgaccgctt tatggctctt cgtgatgacg tgttaaaagc attagaaact gcgcgaaatg 1581601 aaaaaattat cggtaaatct ttggaagcaa acctgaaatt gtatccaaac aaagaaaaca 1581661 aggagctctt ggcttccata aaagaaaacc tttctcagct gtttattgtg tctgaactga 1581721 caatcagcga agaaaatgaa gcgccgaacg atgcgcaaag ctttgcgacg ggtaaaatcg 1581781 ctgtcgagaa agcggaaggc gaaatgtgtg agagatctcg tgtgatttca aaagatgtag 1581841 gggcaaatcc gaaatatcct acactttcat tacgcaacgc tgaaatcgtt gaaaaatact 1581901 atcaaaaata atgcaaaaga gcccggcgta aaagccgggc tttttttgtg ccaagagtga 1581961 catcctttag aacgaaagga aaaatcttat gggctttaga tcatcattca caggcaacaa 1582021 taaagatact acgttaagag caggagttgt gaagaatgaa tgatcaactg accgcaattt 1582081 atacggaact tcttctgatg aaagaagaat tacagtcgag attatttgag tattcttgct 1582141 ttcaggtttc tacaagcccg caagcagcaa tcaatcaaaa acaaaaagca actctgatct 1582201 atcatattaa agaagaactt caagacgttc tccttgcatt gtccaaaatc gaaaacggca 1582261 cattcggata ctgtgaagaa actggggccc ccattcctct tgcaaagctg gcagtgctgc 1582321 cgacggcccg aacagcaaac gattttcttt attctgtcca atttgagaaa aaaacgcttc 1582381 cgatatggaa atcaacggat atcgaatatg gtcaggcact gtatgaataa cagtgtctgt 1582441 ccggttaata tgcctgatat ttctttactc cagtgctttt tattgataaa atgcataatg 1582501 gattaaagta accgtaaact ggaggaacgt ttgtgctgta ttatatgatt gcactactta 1582561 ttattgcagc cgatcaattg acaaaatggc tagttgttaa gaacatggaa cttggccaaa 1582621 gcattccgat cattgatcag gtattctata tcacctccca tcgcaatacg ggtgctgcat 1582681 gggggatatt agcgggtcaa atgtggtttt tctacctcat aacaaccgct gttattattg 1582741 gtattgttta ttacatacag cgttatacaa agggacaaag gcttcttggc gttgccctcg 1582801 gacttatgct tggcggtgcc atcggcaact ttatcgatcg ggctgtcaga caggaagttg 1582861 tggattttat ccatgttatt attgtcaatt acaattaccc gatatttaac atcgcggact 1582921 cttcactatg tgtcggcgta atgcttttat ttatacaaat gctgttggac agcgggaaaa 1582981 agaaaaagga gcaatagcat gaatcaaatt gatataaccg cttcagaaga acaaaaaagt 1583041 gagcggattg ataaattttt ggcatcgact gagaatgatt ggtcaagaac ccaggttcag 1583101 caatgggtaa aagacggaca ggttgtcgtg aacggaagcg cggtgaaagc gaattataaa 1583161 attcagccgg gtgatcaggt gaccgtcact gtacctgaac cggaagcgct cgacgtcctg 1583221 gcagagccta tggatctgga tatttattat gaggaccagg atgtgctggt cgtcaacaaa 1583281 cctcgcggaa tggttgttca cccagcaccc gggcatctta cgggcacact tgtaaacggt 1583341 cttatggctc attgcacaga cctttccgga ataaatggtg tgatgcgccc gggtattgtt 1583401 cacagaatcg ataaggacac gtccggttta ttaatggtgg cgaaaaatga tatggcgcac 1583461 gagtcactcg taaaccaatt ggtcaacaaa acggtcacgc ggaaatatac ggcggttgtc 1583521 cacgggctta tttctcatga tgacggcaca attgacgcgc cgatcggacg ggataaaaaa 1583581 gaccgtcaaa gcatgactgt gacacgtgat ggcaaaaacg ctgtcactca ttttcatgtg 1583641 cttgagcgtt ttcaggattt tacgttagtg gagtgccagc ttgaaacagg gagaacccat 1583701 caaattcgtg ttcatatgaa atatatcgga ttcccattag caggcgatcc gaaatacggc 1583761 ccaagaaaaa caatcgactt taatggccaa gcgcttcacg cgggagtttt aggttttgac 1583821 catccacgaa caggagaata tgtcgaattt gaagcgccgc ttcccgagga tatggcagaa 1583881 ttaatcgaaa acctcagaaa aaacggttga cagagggttt cttttctgaa ataataaacg 1583941 aagctgaata gattctttaa aacagtccag agaggctgag aaggataacg gatagacggg 1584001 atgcgtgtat aggcgcgcac cttgtcctaa aacccctcta tgctctggca ggaggggttt 1584061 tttcttctat atgaactgtg aggtgtcaca cattgaatca aaaagctgtc attctcgacg 1584121 aacaggcaat tagacgggcg ctgaccagga ttgctcacga aatgatcgaa cgcaataaag 1584181 gaatgaataa ctgcattctt gtcggcatta agacaagagg gatttacctg gcaaaacgcc 1584241 ttgcggaacg cattgaacag attgagggaa atcctgttac agtcggtgaa attgatatta 1584301 ctctttacag agatgatctt tctaaaaaaa caagcaacga tgaaccgctt gtaaaaggtg 1584361 cagatattcc ggtagatatt acagatcaaa aagtcattct cgttgatgat gttctgtata 1584421 ccggaagaac agtcagagca ggaatggatg cgcttgttga tgtaggcaga ccttcctcca 1584481 ttcagcttgc agtgcttgtg gacagaggac accgggagct gccgatccga gcggattata 1584541 tcgggaaaaa catcccgaca tcaaagtctg aaaaggttat ggtacagctt gatgaggtag 1584601 accaaaacga tctcgtcgcc atttatgaaa acgaataata gatcaccttt ttaagggcaa 1584661 tccagagagg ttgcaaagag gtgcacaaca aaggcccaaa aagtattcgg caggtctttg 1584721 tatgcctctt tgcgtaaaaa agcaaagagg tttttttata cagtcattga gtcatcctaa 1584781 aatgaaagtc aacaatcagg gggaaatcat catgagtaag aaaaaagtaa atttaggggt 1584841 cagggatgtc ccgacacctt tctcttgggt ttcattcagc cttcagcatt tgtttgccat 1584901 gtttggctca accattttgg ttccgaagct cgtcggaatg agtcctgctg tggcgttggt 1584961 gacaagcggc atcggaacac tggcgtacct tcttattacc aaaggacaaa ttccggcgta 1585021 tctcggttca tccttcgcct ttatttctcc gatcattctg gtaaaagcga ccggcgggcc 1585081 gggagcggca atggttggag cgtttcttgc agggctggtg tacgggctga ttgccttatt 1585141 gattaggcag cttggaacag gatggctgat gaagattctc ccgcctgtag tcgtagggcc 1585201 tgttattatc gtcatcgggc tgggactggc aagcactgca gtaaacatgg cgatgtatgc 1585261 tgatccgaac gcgagtgagt tggtctacag cttaaagcac tttagtgtcg caggagttac 1585321 gctggcaatt acgattattt gtgcgatttt cttacgaggg tttttaagcc tgattccggt 1585381 tctgatcgga atcatcggcg gatacctgtt tgcccttact caagggattg tcaacttcca 1585441 gccggtgctt gacgcgaaat ggtttgcagt gcctgaattt atcattccgt tcaaagatta 1585501 ttcaccgtca gttacgctcg gcatcgcagc cgcaatggtt cctgtcgcat ttgtcacaat 1585561 gtcagagcat atcggccacc aaatggtgct gagcaaggtt gtcggacaag acttcattaa 1585621 aaagccaggt cttcatcgct ctattatggg tgacagtgtg gcgacaatcc tcgcttccct 1585681 gatcggcggc cctccgacaa cgacttacgg agaaaacatt ggcgtgctgg ccatcacaag 1585741 agtattcagc gtctttgtca tcgggggcgc ggcagtgatt gccctttgct tcggctttat 1585801 cggcaaaatt tcagcgctga tcagttcagt gccgtcagcg gtcatgggag gcgtctcctt 1585861 cctgctgttc ggaatcattg cttcaagcgg cctgagaatg ctgattgaca acaaaattga 1585921 ttatgaaaac aacagaaacc tcattattac atcagttatc cttgtcatcg gtgtaggagg 1585981 cgcttttatc caagtgtctc agggcggatt ccaagtgtca ggaatggcgc ttgccgcaat 1586041 tgtcggtgtc atcttaaacc tgattcttcc gcaggcgaag gaagagcagg cagacacatc 1586101 tgaacaacat catatttaaa accttttaat gaaagtccag agaggcttgg aagggttatg 1586161 aagagaagga agcttcaatg ctgccctcta tttaaccata ccccgagtct atcttagacc 1586221 ggggtttttt ttcagcctta agttgaaaag agaggggaaa gaacatgaag catttaacga 1586281 cgatgagtga acttagcact gaggaaatca aagatttgct tcaaacagca caagagctca 1586341 aaagcggaaa aacagacaat cagcttacag gaaagtttgc agcaaacctg tttttcgaac 1586401 cgagcacgag aacgcggttc agctttgagg tcgcagaaaa aaagctgggc atgaatgtgc 1586461 ttaaccttga tggaacaagc acaagcgtgc aaaaaggcga aaccttatat gacacgatcc 1586521 ggacgcttga atcaatcggt gtggacgtct gcgtcatcag gcacagtgag gatgagtatt 1586581 atgaagagct tgtcagccag gtgaacattc cgattctgaa tgcgggagac gggtgcggcc 1586641 agcatccaac acaatcactg cttgatttaa tgacgattta tgaagagttc aatacgttta 1586701 aagggcttac cgtctccatt cacggcgaca tcaagcatag cagagtggca aggtcaaatg 1586761 cggaagtgtt gacaagattg ggtgcccggg tcctattttc cggcccttcg gaatggcagg 1586821 atgaagaaaa tacattcggc acgtatgtct caatggatga agcagttgag tcttccgatg 1586881 ttgtcatgct gctgcgcatt caaaatgaac gacatcagtc cgctgtcagt caggaaggct 1586941 atttaaacaa atacggcttg accgtagaac gggctgagcg tatgaagcgg catgcgatca 1587001 tcatgcatcc tgctccggta aacagaggag tggagattga tgacagctta gtagaaagcg 1587061 aaaaatcaag aatcttcaag caaatgaaaa atggcgtatt tatcagaatg gcagtgatac 1587121 agcgtgcctt acaaaccaat gtgaaaagag gagaagcagc gtatgtcata tctcattaaa 1587181 aacggctgga tactaaacga aaatggtgaa aaaacacaag cggatatccg agtgactgga 1587241 gaaaccatca ccgcaatcgg caagcttgat gcaacggata atgaaacggt aattgatgca 1587301 aaaggtttgc tcgtttcacc tgggtttgtt gatctccacg tgcatttcag agagccgggc 1587361 ggagagaaaa aagaaactat tgaaaccggg gcaaaagcag cggcgcgcgg cggctatact 1587421 acagtagcag caatgccgaa tacgcggccg gttcctgata caaaggagca gatggaatgg 1587481 gtgcaaaaca gaattaaaga aacatcatgc gtaagagttc ttccatatgc atccattacg 1587541 atcagacaaa tcggcgatga aatgacaaac tttgaagcgt taaaagaagc cggggcattt 1587601 gcttttacag atgacggcgt tggtatacag acagcaggaa tgatgtatga agcgatgaaa 1587661 cgggcagccg caattgacaa agcgattgtt gcacattgcg aggacaactc cttaatttac 1587721 ggagggagcg tacatgaggg gacattctcc aaagcgaacg ggctaaacgg cattccttct 1587781 gtgtgtgaat cggttcatat tgctcgcgat gtgctgctgg ctgaggcggc aaactgccat 1587841 tatcatgtat gccatatcag cacaaaagaa tctgtcagag ttgtacgcga tgcgaaaaaa 1587901 gcgggaatca gagtgacagc agaagtatcg ccgcatcatt tgctgctttg tgatgaggac 1587961 atcccggggc tggacacaaa ctataaaatg aatcctccgc tccgcagccc agaagacaga 1588021 gctgctttaa ttgaaggtct tttagacgga acaattgatt ttatcgcaac agaccatgca 1588081 ccgcatacgg aagaagagaa gaacacagaa atgaagctgg cgccattcgg aattgtcggc 1588141 ttagaaacag cattcccgct tctttacaca cactttgtca aaaatggcag ctggtcactg 1588201 aagcagctga ttgactacat gacaatcaag ccatgcgaag cgttcggtct cccatatgga 1588261 acattacaaa cggggcaagc tgcggacatt acgttaatcg atttagaaaa agaagcagtt 1588321 atagacaaag agacattttt atcaaaagga aaaaatacac cattcaacgg catcagttgc 1588381 accggctggc cggtcgctac aattgcggca gggaagcttg cttatgaaga ggggagactt 1588441 gtcaaatgaa gagacgatta gtactggaaa acggagcggt attcgaggga gaagctttcg 1588501 gaagcttaga acacaacatg ggagaagtcg tttttaatac tgggatgaca ggctatcagg 1588561 aaattttatc tgatccttct tactgcggac agatcgtaac attaacatac ccgcttatcg 1588621 gaaattacgg cattaaccgt gatgattttg aatccattac cccttttgtc aaagggctga 1588681 tcatcaaaga attatgtgag ctgccttcca actggcgttc agcatacacc ttagacgagt 1588741 atttaaaaat gaaaaacatt cccggactcc agggaattga tacaaggaag ctgacaagaa 1588801 tgatccgcac ggcaggcgcg ctaaaaggaa cattcgcttc atctgatgaa gatatcgaag 1588861 cagtgctgaa aagactgaac gaaacggaat tgccaagaaa tcaagtatcc caagtatcag 1588921 caaaaacagc atatccgagc ccgggaagag gcaaacgcat tgtcttggtt gacttcggca 1588981 tgaaacacgg gattctaaga gagctgaaca aacggaaatg tgacgtcatc gttgtgcctt 1589041 acaacattac agcggaagag gtgcttcagc tgaaaccgga cggtatcatg ctttctaacg 1589101 gacctggaga cccgaaggat gtgcctgaag cgattgaaat gattaaaggt gttcttggaa 1589161 aagtgccatt attcggaata tgtctcggcc accaattatt cgcgctggcg tgcggggcga 1589221 atactgaaaa aatgaaattc ggccacaggg gctcaaacca cccggtaaaa gagctggcta 1589281 caggaaaagt tgccttaaca tctcaaaacc atggatatac agtttcgtct atcagtaaaa 1589341 cagaactgga agtgacgcat atcgcaatta acgacgatac gattgaaggg ctgaagcata 1589401 aaacattgcc ggcatttacg gttcaatatc atcccgaagc ctcacctggt cctgaggatg 1589461 ccaaccatct atttgacaga ttcatcgaaa tgatcgaaac aacagagaaa gaaggggaag 1589521 cggtatgcca aaacgcgtag acattaacaa aattttagta atcggatctg gaccgatcat 1589581 catcggccaa gcagcagaat ttgactatgc gggaacacaa gcctgtcttg ctttgaaaga 1589641 agaaggctat gaagtcatcc ttgtcaactc aaaccctgca acgatcatga cagatacaga 1589701 aatggctgac cgggtttaca tcgaaccgct cacacctgaa ttcctgacac gaatcatcag 1589761 aaaagagcgc ccggatgcca ttcttcctac actcggaggc caaaccggtt tgaatcttgc 1589821 ggttgagctt tctgaaagag gcgttttggc agaatgcggc gtcgaagtgc ttggcacgaa 1589881 actgtctgcg attcagcaag ctgaagaccg tgacttgttc agaacattaa tgaatgaact 1589941 gaatgaaccg gtgcctgaaa gtgagattat ccactccctt gaagaagcag aaaaattcgt 1590001 cagtcaaatt ggattccctg tcattgtccg cccggcatat acattaggcg gaacaggcgg 1590061 aggcatctgc tcgaatgaaa cagagctaaa agaaatcgtt gagaacggct tgaaattaag 1590121 cccggtacac caatgtctgc ttgaaaaaag catcgccggc tataaagaaa tcgagtatga 1590181 agtcatgaga gacagccagg atcacgccat tgtcgtttgt aacatggaaa acattgatcc 1590241 agttggaatc catactggag acagtattgt tgtcgcgccg agccaaacgc tcagcgatcg 1590301 cgaatatcag ctcttgcgga atgtatcgtt aaaactgatt cgcgcgcttg ggatcgaagg 1590361 cggatgtaat gtccagctcg ccttagatcc agacagcttc caatattaca ttattgaagt 1590421 aaatccgcgt gtcagccgtt catctgccct tgcatcaaaa gcaacggggt acccgattgc 1590481 aaagctcgct gctaaaattg cagtcggact ttcattagat gaaatgatga acccggtgac 1590541 aggaaaaaca tatgcagcat ttgaacctgc tcttgactat gtcgtatcca aaattccgcg 1590601 ctggccgttt gataagtttg aatcagcaaa cagaaagctt ggcacgcaaa tgaaagcgac 1590661 aggtgaggtc atggcaatcg gccgcacgct tgaagagtca ttgctgaagg cagtgcgatc 1590721 actggaagcg gatgtgtatc atcttgaatt gaaggacgcc gctgacattt cagatgagct 1590781 tcttgaaaag cgaattaaaa aggccggtga tgaacgctta ttctacttag ctgaagcgta 1590841 cagaagaggc tacacggtag aagacctcca tgaattttcc gctatcgatg tcttcttctt 1590901 gcataagctg ttcggaatcg tacagtttga aaaagaattg aaggccaatg cgggcgatac 1590961 agatgtgctg agacgggcaa aagaactcgg cttctctgat cagtacatca gccgtgaatg 1591021 gaaaatgaaa gaatctgagc tttacagctt gagaaaacaa gcggggattg cgccggtatt 1591081 caaaatggta gatacatgcg cggcggaatt tgagtcagaa acgccatact tctatagcac 1591141 atatgaagaa gaaaatgaat ctgtcgttac agataagaaa agtgtgatgg tgcttggttc 1591201 gggtccgatt cgaatcggtc agggtgtcga gttcgactat gcgacggttc actctgtatg 1591261 ggcaattaaa caagcaggct atgaagccat tattgtcaac aacaacccgg aaaccgtttc 1591321 aacagacttc agcatctcag acaagctgta ttttgaaccg cttacgattg aagatgtcat 1591381 gcacatcatt gacctcgaac agccaatggg cgttgtcgta caatttggcg gacaaactgc 1591441 gattaacctt gctgacgagc tttctgcacg cggagtgaaa atccttggaa cttcattaga 1591501 agatttagac cgtgccgaag accgggataa atttgaacaa gcgcttggag aacttggtgt 1591561 tcctcagccg cttggcaaaa cagcgacatc agttaatcag gcggtaagca tcgcaagtga 1591621 tatcggttat ccggtactgg tacgcccttc ctatgtactt ggcggccggg cgatggagat 1591681 tgtttaccat gaagaggaac tgcttcatta catgaaaaat gcagtcaaaa tcaatccaca 1591741 gcaccctgta ttaattgata gatacttgac cggaaaagaa attgaagtcg atgcagtatc 1591801 cgacggtgaa acagtcgtca ttccgggaat tatggagcac attgaacgtg cgggcgttca 1591861 ctccggagac tcaatcgctg tttatccgcc tcagtctctc acagaggaca ttaagaaaaa 1591921 aattgaacaa tacacgatcg cattggctaa agggctgaat attgtcggtt tgctcaatat 1591981 tcaattcgtc ttgtcgcaag gcgaggtgta cgtgctagaa gtgaatccga gatcaagcag 1592041 aaccgtaccg tttttaagca aaattacggg tatcccaatg gcgaatctcg caacaaaaat 1592101 cattcttggt caaaagctgg ctgcgtttgg ctatacagag ggccttcagc ctgaacagca 1592161 aggtgtattt gtaaaagcgc cggtcttctc ctttgccaag ctgagaagag tggatattac 1592221 gttagggcct gaaatgaaat caacaggtga agtcatgggg aaagattcga cacttgaaaa 1592281 ggcgctctac aaagccttga tcgcttcagg tattcaaatc ccgaactacg gttccgtgct 1592341 tttaacagta gctgataagg acaaagaaga agggcttgcc attgctaagc ggttccacgc 1592401 gatcggctac aacattttag cgacggaagg aacggcaggc tacctgaaag aagcttccat 1592461 tccagcgaag gtcgtcggaa aaatcggtca ggatggcccg aacttgcttg atgtcatcag 1592521 aaacggagaa gcgcagtttg tcatcaatac gctgacaaaa ggaaagcagc cggcaagaga 1592581 cggttttaga atcagacgtg aatcagtaga aaatggtgtt gcctgcctaa catctttaga 1592641 tacggcagag gcgatattgc gagtgctgga aagcatgaca ttccgtgctg atcaaatgcc 1592701 ggcagtcaac acaaatcagg aggcggcagt cactatatga aaaaagcgta tttgacagta 1592761 tgttctaacc agcaaattgc agaccgggtg tttcaaatgg ttctgaaagg ggagcttgtc 1592821 caagggttta caacccctgg acagttcctt catcttaaag tgagcgaagc ggttacgcct 1592881 cttttgagaa ggccgatcag catcgcagac gtcaactttg aaaaaaatga agtcaccatc 1592941 atttatcggg tagatgggga agggacaaga ctcttgtcac tgaagcagca gggagaactt 1593001 gtggatgtcc tcgggccttt gggaaatggc tttcctgtta atgaagttca acccggaaag 1593061 acggctttgc tggtaggagg cggagtaggt gtgccgcctc tccaagagct gtcgaaacgc 1593121 ttgattgaaa aaggggtaaa tgtcatccac gttttaggat tccaatcggc aaaggatgtt 1593181 ttttacgagg aagaatgccg gcagtacgga gacacgtatg tggcaacagc tgacggaagc 1593241 tacggggaaa ccggatttgt cacagatgtg attaaacgga aaaagctaga gtttgatatc 1593301 ctcctcagct gcgggccgac accgatgctc aaggcgttaa aacaggaata tgcccataaa 1593361 gaagtatatc tgtccatgga ggaacgaatg ggctgcggaa tcggcgcatg cttcgcgtgt 1593421 gtgtgccata caaacgaaag tgagacatcc tatgtaaaag tatgtctcga cgggcctgta 1593481 tttaaagctc aggaggtggc gctgtaatgc tagaggtgaa attgccggga cttgatttga 1593541 aaaacccaat cattcctgca tcaggctgct tcggttttgg aaaagaattt tcacgttttt 1593601 atgatttgtc ttgtcttgga gctatcatga ttaaggctac gacaaaggag ccgcgctttg 1593661 ggaatccgac gccgcgggta gctgagactg gtgctggaat gctcaatgcg atcggtctcc 1593721 aaaatccggg gctggatagt gtgttgcatc atgagctgcc gtggcttgag cagtttgata 1593781 caccgatcat tgccaatgtc gcaggttctc aagtcgatga ttatgttgaa gtcgcagaac 1593841 atatcagcaa agcgcctaat gttcatgctc ttgaattgaa tatttcctgc ccgaatgtga 1593901 aaacaggcgg aatcgctttt ggcacgaatc ctgaaatggc tgccgatttg acaaaagcgg 1593961 tgaaagaggt ttcggatgta cccgtttatg tgaagctatc cccgaacgtg gctaatatca 1594021 cagaaattgc attagcgatc gaggaagcgg gagcggacgg tcttacgatg atcaacacac 1594081 taatcggcat gagactcgat ttaaaaaccg gcaaaccgat attagcgaat aaaacagggg 1594141 gactttcggg ccctgctgtg aagccggttg ccattcgcat ggtgtatgaa gtcagccaga 1594201 tggtcaacat cccgattatc ggaatgggag gcgtgcaaac ggctgaagat gccctggaat 1594261 ttcttctcgc gggagcaagc gcagtcgctg tcggaacagc aaactttgtg aatccttttg 1594321 catgtccaga gattattgaa cagctcccat ctgttttgct ccaatacggc tatcaatcaa 1594381 ttgaagaatg catcggaagg agctggaatc atgaaaaaca acctgcccat catcgcgctt 1594441 gattttgcgt cagctgaaga aacacttgcg ttcttagcgc cttttcagca agaaccgtta 1594501 tttgtaaagg ttgggatgga gcttttttat caagaagggc catctatcgt gaaacaacta 1594561 aaagaaagaa actgcgagct atttttagat ctaaagcttc atgacatccc gactactgta 1594621 aacaaagcga tgaagcgcct tgccagtctt ggagtagacc tcgtcaatgt tcatgctgcc 1594681 gggggcaaaa aaatgatgca ggcagctctc gaaggcttag aagaaggtac gccggctgga 1594741 aaaaaacgtc cgtcacttat cgcggtaacc cagctgacaa gcacatctga acaaatcatg 1594801 aaagatgaac tgctgatcga aaagtctctg attgatacgg ttgtgcacta cagcaaacag 1594861 gcggaagaaa gcggactgga tggagtggtc tgctctgttc atgaagcaaa agccatttac 1594921 caagcggtgt cgccttcatt tctgactgtc actccgggga tcagaatgtc agaggacgct 1594981 gcgaatgacc aagttcgcgt agcgacgcct gccattgcaa gagagaaagg ttcatcagcg 1595041 attgtagtag gacgctcgat tacaaaagcg gaagacccgg taaaagccta taaggctgtc 1595101 agacttgaat gggagggaat caaatcttga aacaaatcat cgcaaaacat ctattagaca 1595161 tccaagctgt atttttacgc ccgaacgagc cgttcacatg ggcaagcggc attttatcac 1595221 cgatctactg tgacaaccgc cttacgctat ctttcccaga ggtcagaaac gatgttgctt 1595281 caggtatcag caagcttgtt aaagagcatt ttcctgaagc tgaaatgatt gcgggaacag 1595341 caactgccgg tattcctcat gctgctcttg cggcggacca tttgaatctt ccgatgtgtt 1595401 atgtgaggag caagccgaag gcgcacggaa aaggcaatca gattgaggga gctgtgcaag 1595461 aagggcaaaa aacagtcgtc attgaagact taatttccac aggaggcagc gtgcttgaag 1595521 cttgtgcagc tttacaagcg gccggctgtg aagtgcttgg tgtcgtctca atctttacgt 1595581 acggacttcc taaagcggag gaagccttcg caaaggcaga actgccatac tactcattaa 1595641 ccgattatga tacgctcaca gaggtcgcgc ttgaaaacgg aaatattcat tcagatgatc 1595701 taaaaaagct gcaaacatgg aaacgaaatc ccgagtcaaa agattggttt aaaaaataaa 1595761 aaataaattc aaatgatgta aagaggcttc aaagccttgc tgtacttgaa aacaggctgt 1595821 gaggcctgtt tttttattaa tcctataaaa aaagtcgggt tgacttatgt tagaattgtg 1595881 ctaaaattta ctacaaatct aaaaacttat caagagcggc tgagggactg gacctatgaa 1595941 gcccggcaac ctgcatagtt tgtaaggtgc tacttccagc aaaatgaatt ccattttgaa 1596001 agataagggc tgcatgctgt tcctgtcttt ctttccgccg gattgaaagt tttttatttt 1596061 aagaggtaaa aaggctatct gtatatcagc agccgcgaat cacattacat gggaaaagac 1596121 aaccggcaga aagctactgt ttgtttgtct ccgaaaggag gaaagaagaa atgttaacgt 1596181 atgataattg ggaagaacca acgattacat ttccggaaga cgatccttat aaaggagcgc 1596241 tgtcagtttt aaaatgggca tacggccatt acggcgatca gcttgtttat gcctgcagtt 1596301 tcggaattga gggaatcgtt ctgattgact taatttataa agtgaaaaaa gacgcagaga 1596361 ttgtgtttct tgatacagga cttcatttta aagaaaccta tgaaacaatt gaacgagtga 1596421 aagagcgtta tccgggtctt aatatcatcc tgaaaaaacc agatctcacc cttgaggaac 1596481 aagccgaaga acatggtgac aaactatggg aaagagagcc gaatcagtgc tgctatctta 1596541 gaaaggtcgt tcctttaaga gaggcgcttt caggacatcc agcctggctt tccggcctgc 1596601 gccgtgatca agggccaagc cgtgccaata cgaatttctt aaacaaagat gaaaaattca 1596661 agtcagtaaa agtttgcccg cttatccatt ggacttggaa agacatttgg agatatacat 1596721 cccggaatga actggactac aatccgcttc atgaccaagg ctatccaagt attggctgtg 1596781 cgccttgcac ttctcccgct tttacagcag aagatttgcg ctcaggcaga tggaatggta 1596841 tggcgaaaac agaatgcgga ctgcatgaat aaggagctgc aaaatggaat tagccgctat 1596901 tttatttagc ttgtttttcg cgatgaatat tggtgcaagc ggcgctgcag cttcgatggg 1596961 ggttgcttac ggctccggag ccatcaaaaa gaaaacttac gctttgatcc tatgcgcagt 1597021 cggtgtcttt gccggggcgg tcattggcgg aggcgaggtt gtaaaaacaa tcagctccgg 1597081 cattattcct gagcagacga ttacactgac gattgtttgc atcattattg gagctgctgc 1597141 cctgtcgctc tttactgcta atctgctcgg cattcctttg tcgacaagtg aagtaacagt 1597201 cggcgcggtt gtcggcgtgg gagtggctta taaagtattg tttgtgaaca atcttctgat 1597261 cattgtgtca ttttgggttt ttgtcccgct gttcgctttc ggcttcacct atttcgtatc 1597321 taagctgttt cgttatttta agattgaagt aaaatcttct aaaaagcaaa aaatcctcgg 1597381 cattgttttg ttagttgccg gatttttcga agcattctct gccggcatga ataacgtggc 1597441 gaatgctgtt ggcccgttag tagctgccgg tgtgcttgat gtcggaaaag gaaccttgta 1597501 tggaggagct tttgttgctc ttggcgcact gttattaggc cggcgagtgc tagaaacaaa 1597561 cgggaagaaa attacgaggt tctccaaagg ggaaggcatt ctcttatccg gtacaggagc 1597621 gggactggtg atcatcagtt ctgtatttgg gatgccggtg cccttggcgc aagtcacgtc 1597681 atcgtctatt atcggaatag gcatggcgaa aaacggtccg aacgtgttcc ataaacaagt 1597741 tgttcaaacg atgctgaagg tatggatcgt atcgccgttt ttatctttat cgatttctta 1597801 tctgcttgta tccttgtttt taaaagcaga ttattattcg atctttatca tggtaagtgt 1597861 gcttttagcg gcgggcggtg ccatcagcct gacaaaggcc attcgtaaag agagacgctc 1597921 agtccacgaa caaggcgggg gaatctgatc attaatctga gtaattttat aagttaacta 1597981 ggaggagatg gatattatga gcttagcacc acacggagga acattagtaa acagagtaga 1598041 tgaatcatat gatgtgagcg gcattcaaaa agaaattgaa cttgatttaa tttctttcgc 1598101 ggatttggaa ttgatcggta tcggtgcata cagcccgatt gaaggtttct ttaatgaaaa 1598161 agattacgta tcagtggtcg aaaacatgcg tctttcttcc ggcgttgtct ggtctcttcc 1598221 aatcacgctt ccggtcgatg cgcaaaaagc agcggaactg tcacttggtg aaacggtaaa 1598281 gttaacgtat gaaggagaaa cttacggcgt tatccaaatc gaagacctgt acgtgcctga 1598341 caaacaaaaa gaagctgtca atgtgtacaa aacagatgaa caggagcatc ctggtgttaa 1598401 aaagctgttc agccgcggca atacatatgt cggcggaccg attacgttga ttaaaaaagc 1598461 ttcaaaacag ttccctgaat ttacatttga accgtcagaa acgagacgcc agtttgcgga 1598521 aaaaggctgg gaaaccattg tcggtttcca aacaagaaac cctgttcaca gagcgcatga 1598581 atacattcaa aaaacggctc ttgaaacagt agacggcttg ttcttgaatc cgttagtagg 1598641 tgaaacaaaa tctgatgaca ttccagctga tgtacggatg gaaagctacc aagtgcttct 1598701 tgatcattat tacccgaaag atcgtgtttt ccttggtgtc tttttagcgg cgatgcgtta 1598761 tgcaggcccg agagaagcaa ttttccacgc gcttgtcaga aagaactacg gctgcacaca 1598821 tttcatcgtc ggccgtgatc atgcaggtgt aggcgactat tacggaacat acgaagcaca 1598881 ggaactgttt gacacattta aacctgaaga actcggaatt acaccgctga aatttgagca 1598941 cagcttcttc tgtaaaaaat gcggaaatat gggaacagca aaaacttgcc ctcatggcag 1599001 agagcatcac gtcattttat caggcactaa ggtaagaggt atgctgagag acggtgtgct 1599061 gccgcctgct gaattcagtc gaaaagaagt agtagaagtg ttaatcaaag ggatgaagaa 1599121 aaaagaagaa gtaggcgtat cttaaggagg actggcagtg acaaatcgcg atattgtatg 1599181 gcatgaagcc tctatcacaa aagaagagta tcagcaaaaa aacaagcata aaagctccat 1599241 tctctggctg acagggttaa gcggctcagg caaatcaacc attgccaacg ccgctgcgag 1599301 agaattgttt gagcaaggct accaagtcat tgtgctggac ggggataata tccgtcacgg 1599361 cctaaatagg gatcttggtt tttctgatga agaccgaaaa gaaaacatcc gccggatcgg 1599421 agaggtggcg aagctttttg ttcagcaggg aaccattgtg attactgctt ttatctctcc 1599481 tttccgcgag gacagacaac aggttcgcga gcttgtggaa gcgggcgaat ttaatgaagt 1599541 ctacattaaa tgcgaccttg atatttgtga acaaagagat ccgaaagggc tttacaaaaa 1599601 agcaagaaac ggcgagattc cgttctttac aggaattgat tctccttatg aagaaccgga 1599661 agctccagag ctcgttcttg attcaggaca gcatgaccgt gaagcgtgta aaaatcagct 1599721 gatcgagttt gttaaacaaa aattgagctg aatatgatct gctgcgttct tctcagatgc 1599781 cggaatgcaa gcgagaacat catcacagcg aatcttctgg aagaactcga atagatcggg 1599841 ggaaatacga tggggaaagt atatattgta ggagcgggtc ccggtgaccc tgatctgctg 1599901 acaattaaag cgctgaaagc cattgaaaaa gctgatgtca tcttatatga cagattagta 1599961 aataaagaga ttttacaata tgccaaagag caagcagacc tgatctactg cgggaagctt 1600021 ccggattttc atacgatgaa gcaggaaacc atcaatcgat ttcttgtgaa gtatgcgcaa 1600081 aaagggaaaa tggttgtcag actgaaaggc ggagaccctt ttgtgttcgg gagaggaggg 1600141 gaagaagcgg aatgcctctc tgaaaatgga attccgtttg aaatcattcc cggcattacg 1600201 tctggaatcg cggcagccgc ttatgccggg attcctgtta cccatcggga tgcgggctct 1600261 aacgtcgctt ttgtaacggg tcactataaa aaagaagaag attttgagga aaagtggaaa 1600321 gcgctggcta caggaattga tacacttgtc atctatatgg gtatcaaaaa cgtgcagcag 1600381 attgaaagaa aactccttga aaatggccgg gacggttcta cgccagcagc ctttattcat 1600441 tgggggacaa cggacaagca aaaatctgtt ttttgtacag ttgacaccct ttcagaaacg 1600501 gtgataaaag aaaacattac aaatccgagt ttaattgtca ttggaaatgt tgtaaattat 1600561 cactataagc tggaatggtt tgaatctgaa ctaaaaaaac aagatttaag cgaggcgttg 1600621 taaaaatgaa acaagcaatt ttatatgtcg gccacggcag ccgggtcaaa aaagcgcagc 1600681 aagaagccgc agcctttttg gaaggatgca aggcccacat ctctgtgcca gtacaagaaa 1600741 tcagcttttt agagcttcag gagccgacaa ttgagacagg atttgaagca tgtgtgaagc 1600801 aaggtgccac tcatatcgca gtggtgcctc tgcttctttt aacagctgcg catgcaaaac 1600861 atgatattcc ggaagaaatt gtccgtgttg catctcgata tccatcagtc cgtatttcat 1600921 acggaaagcc gatcgggatt gacgaagaag tagtcaaggc tgtatatcac cgaatgaaag 1600981 acataggtgt tccgtatgaa aatgccagag tggtgctcat cggaagggga agttcagatc 1601041 cagacgtcaa aagagacgta accggaattg ctaatcttct tcaggaaatg gttccagtga 1601101 aggaagtcat tccgtgcttt ttgacagcat gcggccctaa ttacaaagag gttttttcag 1601161 aacttgaaaa agatgacggc ataacaacct ttatcgttcc atatttgctt tttacgggta 1601221 tgctgatgaa tgaaatcgaa cgagaggttc agaaattaaa agcccataat ccgaacgtct 1601281 acctctcttc ctatatcggt tttcatcctc atgtgaaaaa cgcatttttg aaccgtgtga 1601341 gagaaactgc ggcaaattct gagggacaat ttgattttga tggaggttca tatgcttccg 1601401 ctgcacatta gcctggaaaa gaagaaggtt gtgattgcgg ggggcggaag catcgctctc 1601461 agaaggctga aaacggtgat ttctgaggga gctgatataa cgcttgtcag tccggatgtg 1601521 gaaccggaaa tcaagcaaat ggcagaagag cggcgtatca aatgggaaaa acggacaatt 1601581 gaaaaagaag attatctcaa tgctttcttc attattgctg cgacggataa tgcggcagtg 1601641 aacaaagaaa ttgcccaatc cgcttcgcct tttcagcttg tcaattgtgt cagtgacgct 1601701 gagcttggca atgtatatat gccgaaaatc gtaaaaagag ggcatgtcac tgtgtctgtt 1601761 tctacaagcg gagccagtcc aaagcacacg aaagagcttg ctgaaaacgt ggataagctg 1601821 attgacggcg attttgttgc tgaagtgaac aggctttatc agatgagaag aaagaaataa 1601881 gccagagcat acaaatgctc tggcttttct ttatgcggct cagctttttt tgagcttgat 1601941 gacagtatca gcatcaggcg tgacaaagac ggtatgctgg ctgtcataag tgacgaaacc 1602001 gggtttcgcg ccgtttggtt ttttgacatg cctgattttt gtataatcta caggcactga 1602061 acttgaatct ttagcttttg aaaaataagc tgcaattgtc gcggcttcca tgattgtttg 1602121 ctcatcaggt tcgctgcttc tgatcacaac gtgggagccg ggaatgtcct tcgtgtgaag 1602181 ccagatatcg tctctggccg ccactcttgt cgttaaatat tcattttgac gattgttctt 1602241 acccactaaa attgtcagcc ctgaggtgga ttcatatgtt tctaacaccg gattgtgcgg 1602301 tttttgcttt ttctggcctt tttgctgctt agggcgtaaa tatttgccct caacaagctc 1602361 ttccctgatt tcgctgatat cccggggaga agcggacgaa agctgctgaa tcagctgatc 1602421 aaaatattcg atctcttcct gtgccagcct gatttgctcc tcgacaactg cgaccgaatt 1602481 tttcgctttc tgatacttcg tgaaataggc ctgtgcgttt tcagaaggcg ttttgttcgg 1602541 gtttaaagga atcgtgattg tcgggctttc ttcatcataa taattgatga cctcagcctg 1602601 tttatcacct tttttcagca tatataaatt agcggttaaa agctctccgt aaagctgaaa 1602661 ttccttcgcg ttttccgaat actccagggt tttctctaat tttttgattt tgttggcatt 1602721 cttcttccgt tcgttcacaa caaaacgctc aagatcctga gcctgttgct taacccggtc 1602781 tcgttcagct tttccgaaat aaaaacggtc gagcagttcg cttaatgaat caaaacggcg 1602841 cgcttcgccc tttagatgag tcagctccag cagataaaaa tattcctttc cgtttacagt 1602901 cgtaatgttg ggaatgaaac ggtgctcttt cacttcggca aacagtgcca gcaacgcttt 1602961 tggcagtgtg actttgttgg caaggcctgc tctgtgaacc gcttctttgg cgaaaagcgg 1603021 agacacgcct gaaaagtggt cgacaatttg tttatcaagc cttccttctt gaaagctgag 1603081 gtgacgcaaa atatcatctt ctgacgcctc aagaggcgat attttgtcct gagcaggcgg 1603141 aagcttataa tcttggccgg gcagtactgt acggtagctg ttcattgacg gtgataaatg 1603201 cttaagtccg tcgataatca cattttctgc tgcgtcagtc aaaatgatat tgctgtggcg 1603261 gcccataatt tctacataaa gctttcgtac ggtttcatcg ccaatttcgt ttcggctttt 1603321 gatatgaaaa atcataatgc ggtctaagcc cgcttgttca attttctcaa tgaatccgcc 1603381 ttcgatatgc tttctcagca acatgcaaaa cattggcggt tcgcttggat tttcataagc 1603441 ttgtgccgtg atatgcaccc gtgaatagct cggatgtgcc gataataata gtttttggtt 1603501 ttttcccttg gcacggatgt ggaaaatcac atcgtgctta tatggctgat ggatttttgt 1603561 aattcgtccg cccattattt tctcgttaag ttcgtgtgtc attccgtatg taaacatgcc 1603621 atcaaacgac atatgcaata caccctctca ttcttcctgc attcgataat tatagcatga 1603681 aatgggacga gtcagaataa gcatgcttat agagtgatat ctctataaga gagcagggga 1603741 gtggacgagc ggaatgaagt ttcatgaaat gggacaaaca gatttactag aggcaaccaa 1603801 tacgtccatg aaacaaggat taacagaaaa agaggtaaaa aaacgccttg acaagcatgg 1603861 accaaacgag ctgcaagaag ggaaaaaaac ttcagcgctt ctcttgtttt tcgcgcagtt 1603921 caaagatttt atggtgcttg tgcttctggc ggcaacgtta atctcaggat ttcttggtga 1603981 atatgtagat gcggttgcga ttattgcgat tgtgtttgtg aatggcatac tcggtttctt 1604041 tcaagaaagg cgtgctgagc aatctcttca ggctttaaaa gagctttcaa caccgcacgt 1604101 catggcactc agggaaggaa gctggacaaa gattccttct aaggaactgg tgccgggtga 1604161 tattgtgaaa tttacgagcg gggacagaat tggcgcagac gttcgaattg ttgaagcgag 1604221 aagccttgaa atagaagaat cagcgctaac cggggaatca atcccggttg tgaagcatgc 1604281 tgataaattg aaaaaaccgg atgtttcact cggcgatatt accaatatgg catttatggg 1604341 tacgattgtg acccgcggca gcggtgtcgg ggttgtcgtc gggacaggaa tgaatacggc 1604401 tatggggaaa attgccgaca tgcttgaatc ggcagggaca ttgtcaaccc cgctgcaaag 1604461 aagactggag cagctcggga agattttgat tgttgttgca ttgcttctga ccgtacttgt 1604521 cgttgctgtc ggtgttattc agggtcatga tctgtacagt atgtttttag caggtgtctc 1604581 gttagcggta gccgctattc cggaggggct gccggcgatt gtgacagtgg cgctttcgct 1604641 tggtgtacag aggatgatta aacaaaaatc cattgttaga aagcttcctg ctgttgaaac 1604701 gcttgggtgt gcgtctatca tttgctcaga taaaacaggg acaatgaccc aaaacaaaat 1604761 gacagtgacg catgtctggt ccggagggaa aacatggaga gtggcagggg ccggctatga 1604821 accgaaagga agcttcacac taaacgaaaa agagatcagt gtcaatgaac ataagccgct 1604881 tcagcagatg cttctgttcg gagcgctttg taacaactcc aatattgaga aaagagacgg 1604941 cgaatatgtg cttgacggag atccgacaga gggagcgctg ctcaccgcgg caagaaaagg 1605001 cggtttttca aaggagtttg ttgaatctaa ttacagagtg attgaagaat ttccgtttga 1605061 ttccgcacgg aaaatgatga ctgtcatcgt agagaatcaa gacagaaagc gctatatcat 1605121 tacaaaaggt gcgccggatg tactcatgca gcgatcttcc cgtatttatt atgatggctc 1605181 agcggctctt ttttcaaatg aaagaaaagc agaaacagag gcggtattaa gacatttggc 1605241 atcacaggcg ctcagaacga tagcggtcgc ctacaggccg ataaaagcag gcgaaacacc 1605301 gtcaatggag caggcggaaa aagatctgac catgcttggc ctttcaggta tcattgatcc 1605361 cccgcggccg gaagtcagac aggcgattaa agaatgccgt gaagcgggaa ttaagaccgt 1605421 catgattaca ggtgatcatg tagaaaccgc taaagcgata gcgaaagact tgcgcctcct 1605481 tccgaaaagc ggcaaaatca tggacggcaa gatgctgaat gaactttctc aagaagagct 1605541 ttctcatgtg gtggaggatg tgtatgtatt tgcccgcgtt tcccctgaac ataaactaaa 1605601 aatcgtaaaa gcctatcagg agaacgggca tattgtggcg atgacgggag acggcgtcaa 1605661 tgatgctcct gccattaaac aggctgatat cggcgtctct atgggcatta ccgggacaga 1605721 tgtggccaaa gaagcatcat ctcttgttct cgtggatgat aattttgcga cgattaaatc 1605781 agcgataaaa gaaggcagga acatctacga aaatatcagg aagtttatca gatacctgtt 1605841 ggcgtctaac gtcggagaaa tccttgtcat gctgtttgcg atgctgcttg cccttccttt 1605901 accgctggtt ccgattcaga ttttgtgggt caacttggtg acggacggat tgccggcaat 1605961 ggcgctcggc atggatcagc cggaaggaga cgtcatgaag cgcaagcccc gtcatccgaa 1606021 agaaggggta tttgcccgca agctaggatg gaaggtcgtt tccagaggat ttttaatcgg 1606081 agttgccact attttagcgt ttatcattgt gtaccaccgc aatccggaaa acttggctta 1606141 tgcccagacg atcgcgtttg ccacattggt gctcgctcag cttattcacg tgtttgactg 1606201 ccgcagcgaa acttctgttt tctctagaaa tccgtttcaa aacctgtatt taatcggcgc 1606261 ggtattgtca tccattttgc tgatgcttgt agtaatctac tatccgccgc ttcagccgat 1606321 tttccatact gtagccatca cgccggggga ctggatgctc gtcatcggta tgtccgccat 1606381 ccctactttt ttgctggcgg ggtcactttt aacaagaaaa aaataaattc atatgatata 1606441 atcttagggg taatagcgtg tctattgccc ttttattatg agaacaggga agaattgggt 1606501 gttttaaaat gatacgaagt atgacaggct tcggcagtgc aagcaaaaca caagacgatc 1606561 tctctgtaag cgttgaactt aaatctgtga actacagatt taaagaagtg aacgctcgtt 1606621 tgccaaggcc tttgctatat tttgaagata agctgaaaca gaccattctg cagcatattc 1606681 agcgcggaag aattgagctt ttcgtatccg ttgacagcga tatgcttgtt gagaaaaggc 1606741 ttgaaattga ttggccgctg ctcgatgagt ttgtcgcagc cgcgagagat atgaagaagc 1606801 ggtatcaatt gtctgcagag cccgatgtaa tggatttctt taagcttgat catgtcgtcc 1606861 aggttcatga agaacagacg caaaatgaca agctggaggc gttgatcatc gatgctgcag 1606921 aagaagcggt aaaaggtctc tgtgaaatgc gtgaaaaaga ggggctgctc ttagcgaaag 1606981 actgcctgat gcatattgat cagcttgaag agctggtgag agaaactgaa ttgctggctg 1607041 cagatgtcgt atctcgttac cgggaacggc tgtatgccag aatcaaagaa tggactgaag 1607101 acgtattaga cgagagccgg cttgtaacag aatgcgctat ttttgcagac cgctctgata 1607161 tcactgaaga gattacaagg ctgaagagcc acttcgccca gtttcgtgat atattagcta 1607221 gtggcggagc tgtcgggcgc aaactcgact ttcttgttca ggagctcaat cgggaagcaa 1607281 atacgatcgg ctcaaaagca aatgatcatc agatcacaaa gcttgtcgtt gaaatgaaaa 1607341 gttctattga aaaaataaaa gaacaagtgc aaaatataga atagtgactg tgcgtattgt 1607401 ttacagacgg tcttactagg ctaaactaga gacgtctatt ttacaggggg aacgtagaag 1607461 atgacgatta aactgattaa tatcggattt ggcaatatca tctccgccaa tcggatgatt 1607521 tcgattgtca gcccggagtc tgcgccaatc aaacggatga ttcaggatgc aagagaccgc 1607581 ggaatgctaa ttgacgctac atacggacga agaacccgtg cagttgtcgt catggatagt 1607641 gatcacatta tcttatctgc cgtccagcct gagacagttg cacacagact ttctgttaaa 1607701 gaagaaatta tggatgaagg gcaggggtaa ttgccgcatg aaagaaagag ggttattaat 1607761 cgttctctca ggtccctcag gagttggtaa aggaacggtt cgacaagcga tcttttcgca 1607821 ggaagacaca aaatttgaat attcgatttc agtaaccaca agaagtccaa gagagggcga 1607881 agtgaacgga gtcgattatt ttttcaaaac aagagacgaa ttcgagcaaa tgattgcgga 1607941 caacaagctg cttgaatggg cagagtatgt cggcaattat tacggcacgc cagtcgatta 1608001 tgttgaacag acgcttcaag atggaaaaga cgtcttttta gaaattgaag ttcaaggggc 1608061 tcttcaagtg agaaatgctt tcccggaagg cctgtttatt ttccttgcgc ctccaagcct 1608121 ttctgaactg aaaaacagaa tcgtgacacg aggaacagaa acagacgctc tgattgaaaa 1608181 tcgaatgaaa gccgcaaaag ctgagatcga aatgatggat gcttatgact atgtcgttga 1608241 aaacgataat gtcgaaacgg cttgcgataa aatcaaagca atcgttcttg ctgaacattt 1608301 gaagcgtgaa cgcgttgcac caagatataa gaaaatgctg gaggttgaat aatcaatgtt 1608361 agatccgtca attgattctt taatgaataa attagattca aaatatacgc tggtgactgt 1608421 ttctgcgaga cgtgcccgtg aaatgcaaat caaaaaagac caaatgattg aacatacgat 1608481 ttcacacaaa tatgtaggca aagctttaga agaaattgat gcaggcctgc tttcgtttga 1608541 aaaggaagac cgcgaatagt agcacaagta gcaacctata tcatgtaggt tgttattttt 1608601 ttccgtgcgg ttttgtaaag tgcagagggg gagaattcat tgcttaacaa tcgaaatgtg 1608661 ttactttgcg tgagtggagg catcgctgtt tataaagcct gtgcgttaac gagcaagctg 1608721 gttcaggcag gagcaaatgt caaagtgatt atgactgaat ccgcttgccg attcgtttca 1608781 ccgctgacat ttcaggcatt gagccgccac gaagtctata cagatacatt taaagaacaa 1608841 aatccaagcg tcatttctca tattgatgcc gcagactggg ccgacttgat tatcgtagcg 1608901 ccggctacgg ctaatgtgat tggaaaactg gcaaacggca tcgctgatga tatgctgacg 1608961 acaacattgt tggcagcaac ggctcccgtt tggatcgcgc cggcaatgaa cgttcatatg 1609021 tatgaccacc cggcagtcaa acgaaacatt tctgttcttt atcaggacgg ttattgtttt 1609081 attgagccaa gtgagggcta tttagcatgc ggttacgtag gaaaaggcag attggaagag 1609141 ccggaaaaca tcgtaaagct ggccgaaaaa cattttgctg aagaaacatc cgctccttta 1609201 gaaggcaagc atgtggtcat tacagccggc ccaacgcggg aagcgattga tcctgtccgg 1609261 ttttttacca ataaatcgac gggcaaaatg ggctacgcac tggcggaggc tgctgttcag 1609321 ctcggcgcac gggtaatctt aatttctggg cctgtttcac ttgatcagcc taaaggcctt 1609381 gctgagttta tccctgttca atcggctgcg gatatgcgcg aagctgtgct ctctgtgtat 1609441 gacgcaagcg atatagtcat taaaacagct gcggtagccg attttacgcc gaaaacagta 1609501 tttgaccata aaatgaaaaa acaagacggc ggcatgacct tagaactgaa aagaacagtc 1609561 gatattttga aagaattggg cgagaaaaag aaagagcaga ttttggtcgg atttgccgcc 1609621 gaaacacaag acattgaaca ctatgcacgt aaaaagctcg ccgctaaaaa ccttgatttg 1609681 attgtggcaa atgatgtgaa agcaaatggg gccggttttg gtgctgatac gaatatcgtg 1609741 acaatctttt tcaaagacgg gcataaacgc gaactcccga ttatgtctaa gctcgatgtt 1609801 tcttttgaaa tccttcagga gatcgcagcc ctctcaaaac aaaccggaga gcgctcatga 1609861 attttgcaga agtcatcgtt gatgtcagca ccaaaaatat agacaggcct tttgattata 1609921 aaatcccaga ccatctgaag ggcatgatca aaacggggat gcgggtcatt gttccgtttg 1609981 gcccccgtaa gattcaaggg tttgtgacag cagtcaaaga agcatctgac ctatcgggaa 1610041 aatctgtcaa ggaagtagag gatttattag atcttacacc tgttctgaca gaggagctta 1610101 tgattctgtc atcatggctg tcagacaaaa cgctgtcttt taaaataacg gcgcttcaag 1610161 caatgctgcc tgccgcctta aaggcgaaat atgaaaaaga attaaaaatt gcacacggag 1610221 ccgatcttcc gccgcaagtg gaacggctgt tttctgaaac aaagacgctg ctgtattcag 1610281 atatacccga tcatgagacg ctgaaactga ttcaaaggca tgttcaaaaa ggggacattg 1610341 acgtgacgta taaagtcgcg caaaaaacca ataaaaaaat ggtcaggcat attcaggcaa 1610401 atgcgagtaa agaagagctt gctaagcagg ctgagggatt gtcccgccaa gcagcaaaac 1610461 agcaggcgat tcttcacttt ctcatctctg agccggaagg tgtgaaaatt cctgcggcgg 1610521 aattgtgcaa aaaaacggac acgagctctg caaccatcaa aacccttatc caaaaagggc 1610581 ttttgaagga aagctatgaa gaggtttaca gagatcccta tcaggacaaa atgttcaaaa 1610641 aaacagagcc cctgccgctg acagacgaac agagggctgc cttcgagccc atacgcgaga 1610701 cattggacag cgatgagcat aaagtgttcc tccttcacgg cgtgacagga agcggaaaaa 1610761 ccgaaattta tctgcaatca attgaaaaag tactggcgaa aggaaaagaa gccatcgtcc 1610821 tcgtaccgga aatatcgctg acgccgcaaa tggtcaaccg cttcaagggc cgcttcggct 1610881 cccaggtggc agtcatgcac agcggtttat ccacaggaga aaaatatgac gagtggcgta 1610941 aaatccaccg gaaggaagta cggcttgtcg tcggtgccag atccgccatt tttgctccgt 1611001 ttgaaaatct cggaatgata atcatcgatg aagagcacga gtcttcctat aaacaggaag 1611061 aaatgccgcg ctatcatgcg aaagaggtgg caatcaagcg ggctgagcat cacagctgcc 1611121 cggttgtatt agggagtgct acgccgacat tagaatcata tgctagagcg caaaagggcg 1611181 tatacgagct tctttcactg aagcaccgtg ttaaccatcg ggtgatgccc gaggtttcgc 1611241 ttgtcgatat gagagaggag cttagaaacg gcaatcgctc gatgttttca gttgaattga 1611301 tggaaaagct tgaagaaacg attgccaagg gtgagcaggc ggtgctgttt ttaaataaga 1611361 ggggctactc ttcctttgtg atgtgcaggg attgcggcta tgtcccgcaa tgcccgcact 1611421 gcgacatttc catgacgtat catcgttacg gccaaaggct gaaatgccat tattgcggac 1611481 atgaagagcc tgttccgcac acttgtcctg aatgcgcaag cgagcatatc cgctttttcg 1611541 gaacgggaac acagcgagtg gaggaagagc tgacaaaagt gctgccaagt gcgagagtga 1611601 ttcggatgga tgttgacacg acatcacgga aaggcgccca tgaaaaatta ctgtcagctt 1611661 tcggagaagg aaaagcggat attcttctcg gaacgcaaat gatcgcgaaa gggcttgatt 1611721 ttccgaatgt cacgcttgtc ggagtgttaa gtgctgatac aacacttcat attcctgatt 1611781 tcagatcggc tgaaaaaaca tttcagctgt taacgcaagt cagcggccgg gcaggcaggc 1611841 atgaaaagcc cggccatgtc atcattcaaa cgtatacacc gtctcattac agtatccagc 1611901 tgacgaaaac acacgattat gaaacgttct atcagcatga aatggcgcac aggagagagc 1611961 aatcctatcc gccatactac tatttggctc ttgtgactgt ttctcatgag gaagtggcga 1612021 aagcagcggt tacagctgaa aaaatcgctc attttttgaa agcaaactgc ggagctgaca 1612081 cgaaaattct cggaccaagc gcgtcgccga tagccaggat caaagataga tatcgctatc 1612141 aatgcgtgat aaaatacaaa caggaaaccc agttatccgc tttattgaag aagatactgg 1612201 aacattataa acgcgaaatt gaacaaaaac atgtaatgat ttcaattgat atgaatcctt 1612261 atatgatgat gtaagatctc acgtcttgga gggtaacaaa ttggcagtaa aaaaggtcgt 1612321 cacacatcct gcggaggttt tggaaacacc tgcggaaacc gtgactgttt ttgataaaaa 1612381 gctaaaaaaa ctgcttgatg atatgtacga caccatgctt gaaatggatg gtgtcggact 1612441 ggcagcgccg caaatcggca ttttaaaaag agcggccgtc gtagaaatcg gggatgacag 1612501 agggagaatt gatctcgtta atcctgaaat tttagaaaaa agcggcgagc aaaccggaat 1612561 tgaaggatgc ttgagctttc ctaacgtcta tggtgatgtc acacgtgccg attatgtcaa 1612621 agtgcgtgcg tttaaccgtc agggaaaacc gttcattctg gaagcgcgag gctttttagc 1612681 aagagccgtg cagcatgaaa tggaccactt agacggtgtg ctgtttacat ctaaaataag 1612741 taaatactat acagaagatg aactagcgga tatggaagga tgatttgatg acgagaatcg 1612801 tatttatggg aacgccggat ttttcagttc ctgttttaag aaccctgata gaggacggat 1612861 atgaagtagt gggggtcgtc acacagccgg accgtccgaa gggcagaaaa aaagtactga 1612921 cacctcctcc ggtaaaggaa gaggcattgc gccacggcat cccggttctt cagccggaaa 1612981 aagtcagatt gacagaagaa attgaaaaag tgctggcatt aaagcctgac ctgattgtaa 1613041 cggcggcatt cggacaaatt ttgcctaaag agcttctcga cagtccaaaa tacggctgca 1613101 ttaacgttca cgcatccctt ttgccggaac tgcgcggcgg tgctccgatc cattattcca 1613161 ttctgcaggg aaagaagaaa accgggatta ccattatgta tatggtagaa aaattggatg 1613221 cgggcgatat gatctcaaaa gtggaagtgg acattgaaga aaccgacaat gtcggaacac 1613281 tgcacgataa attaagcgtt gctggcgcga agctattgtc tgaaacggtt ccaaacgtta 1613341 ttgccggcag catatcacct gaaaagcagg atgaagagaa agcgacgtac gcgcctaaca 1613401 ttaaaagaga gcaagagctg ctcgactggt ccagaacggg cgaagagctt tacaaccaga 1613461 tccgcggctt aaatccatgg cctgttgctt atacgactct aaacggacaa aacttgaaaa 1613521 tatgggcgtc gaaaaaaata gcggcaccaa caacagctga gcccggcaca gtcgttgcag 1613581 ttgaaaagga aggaattatc gttgccacag gtaacgagac ggctctgtta ttaaccgaac 1613641 tccagccggc aggcaaaaaa cgaatgaaag gcgaagactt tgtgcgaggc gctcatgttg 1613701 aagccggtga tgtgttagga gtaaacaatg aaaaaaacta gtgttcgtga catcgccctt 1613761 gaggcgctga tcaaattaga acaaaaccag gcatacagca acctgctgct gaaatcggtc 1613821 attaaatcaa atgaactgag tgatcagaac agagggcttt tgactgaact tgtctatggt 1613881 acattacaaa ataagatcgc gcttgattat atgcttaaac cgtttatcaa taagcctcaa 1613941 aaggtaaagc cgtgggtgat tcagcttctt cgcctatcct tatatcaaat ggagtatttg 1614001 gagaagattc cagacagggc agccattcat gaagcggttg agattgctaa aatccgcgga 1614061 cacaaaggca ttgcttcatt tgtcaacggc gtgctccgtt ctattcagcg cgaaggtgtt 1614121 ccatcctttg acgcgatcga agatcctgtc cgccggctgg cgacagaaac aagccatccg 1614181 gaatggcttg tgaaagagtg ggcggatgcg tatggatttg aagctgcgga aaagatttgc 1614241 cgcatccatc tcattccgcc gaaacagacg ctgcgtgtca atcaaatgaa agcagacaga 1614301 gctgagctgc ttgaccaaat ggctgctgag ggaatcgaag ttgaaaaagg cgacctcgct 1614361 gaagatgctg tgaagctctt aaagggaaca attgccggaa ctcatttctt ccaaaacggc 1614421 gaagtttcta tccaggatga gagctccatg ctcgtcgccc gcgcccttga tcctaagtca 1614481 gatgaaacag tgcttgacgc gtgtgcggcg cctggcggaa agtcggctca tatcgcagaa 1614541 ttaatgaaga acaaggggag cgttacgtcg cttgatcttc acaaacataa agtgaagctg 1614601 atcaaagaag cggcagatcg gcttggcctg acaatcattc atgcggaaac aatggatgct 1614661 agaaaagcgg gggaaacgtt tgaaaacgaa cagtttgacc gaatattggt cgatgccccg 1614721 tgctcaggtt tcggtgttat cagaagaaag ccggacatga aatacacgaa aaaacctgac 1614781 gacagcgccc gtctagctga aatccagctg tcgatcttga gggaaatcgc accattagta 1614841 aaaaaaggtg gcactcttgt ctacagtacg tgtacaatgg accggacaga aaatgatgaa 1614901 gtaatacatg cgtttataca agaacatcct gattttgaac ccgatttgtc tcttgaaaag 1614961 cggctgcctg aaaaggtgag accctttgtt cgggatggaa ggcttcaaat ccttcctcat 1615021 tatttcggaa cagatggttt ctttatttgc agcatgagaa agaagggata agcaatggca 1615081 gaacttaata aaacaaaagt aagaaaagaa ttgcggacag agcgtccgtc tatttattct 1615141 tttgaattag atgaaatcaa acaatggctg acagacaatg gagagaaacc gttccgtgca 1615201 gcccagatct ttgaatggct atatgaaaaa cgcgtatctt cttttgaaga tatgacaaac 1615261 ctctcaaagg atctgcgtga gaaattaaac actcgctttg tgttaacaac gctgaaaacg 1615321 gctgttaaac aaacctctca agacggtacg atgaagtttt tgtttgagct tcatgacggt 1615381 tataccatcg aaaccgtttt aatgagacac gagtatggca attctgtatg tgtaacgaca 1615441 caagtcggct gccgtattgg ctgcacattc tgcgcgtcaa cgcttggagg cttaaaacga 1615501 aaccttgaag caggggaaat tgtcgctcaa gtagtcaaag tgcaaaaagc tcttgatgaa 1615561 acggatgaac gcgtcagctc tgtcgtgatc atgggaatcg gcgaaccttt tgataacttt 1615621 aacgaaatgc tcgctttctt gaaaatcatt aaccatgaca agggcctgaa tatcggtgct 1615681 cgccatatta cggtctctac gagtggaatc atcccgaaaa tttacgaatt tgctgatcag 1615741 caaatgcaga ttaactttgc aatttctctg cacgcgccga acacagaaat cagaagccgt 1615801 ttgatgccga ttaacagagc atataaactg cctgatctaa tggaagccgt taaatattat 1615861 attaataaaa caggacgccg tatcagcttt gaatacgggc tgttcggagg cgtaaacgac 1615921 caggtggaac acgccgaaga gcttgccgac ttgctggaag gagtcaaatg ccacgtgaac 1615981 ttgattccgg taaactacgt gcctgaacgg gactatgtgc gcacaccgcg tgatcagatt 1616041 tttgcttttg aaaaaacgct gaaatcccgc ggagtaaatg tcacaatccg aagagagcaa 1616101 ggacatgaca ttgacgcagc ctgcggtcag cttcgcgcga aggagcgtca agacgagacg 1616161 aggtgatgag ggttgttaac agccttaaaa acagatacag gaaaaatccg ccagcataat 1616221 gaagatgatg cggggatatt caaggggaaa gatgaattta tattagcggt tgtcgctgat 1616281 ggcatgggcg gccatcttgc tggagatgtt gcgagcaaga tggctgtgaa agccatgggg 1616341 gagaaatgga atgaagcaga gacgattcca actgcgccct cggaatgtga aaaatggctc 1616401 attgaacaga ttctatcggt aaacagcaaa atatacgatc acgctcaagc ccacgaagaa 1616461 tgccaaggca tggggacgac gattgtatgt gcacttttta cggggaaaac ggtttctgtt 1616521 gcccatatcg gagacagcag atgctatttg cttcaggacg atgatttcgt tcaagtgaca 1616581 gaagaccatt cgcttgtaaa tgaactggtt cgcactggag agatttccag agaagacgct 1616641 gaacatcatc cgcgaaaaaa tgtgttgacg aaggcgcttg gaacagacca gttagtcagt 1616701 attgacaccc gttcctttga tatagaaccc ggagacaaac tgcttctatg ttctgacgga 1616761 ctgacaaata aagtggaagg cactgagtta aaagacatcc tgcaaagcga ttcagctcct 1616821 caggaaaaag taaacctgct tgtggacaaa gccaatcaga atggcggaga agacaacatt 1616881 acagcagttt tgcttgagct tgctttacaa gttgaagagg gtgaagatca gtgctaatcg 1616941 gcaagcggat cagcgggcgt taccaaattc tccgcgtcat aggcggcggg ggaatggcca 1617001 acgtgtattt agctgaggat atcattctag accgtgaagt cgcaattaaa atcctgcggt 1617061 ttgactatgc aaatgacaat gaatttatca gacgtttccg cagagaagcc caatccgcat 1617121 caagcctcga tcacccgaat attgtcagca tttatgattt gggcgaggaa gatgatattt 1617181 attatattgt catggaatac gttgaaggca tgacgcttaa agaatacata acagcaaatg 1617241 ggccgcttca ccctaaagaa gcgctgaaca tcatggagca aattgtctca gccatcgctc 1617301 atgcccatca aaaccagatt gttcacagag acatcaagcc gcataacatt ttgattgatc 1617361 atatgggaaa tatcaaagta acggattttg gaattgcgac ggcactaagt tcgaccacaa 1617421 tcacccatac caattcagtt ctgggctcgg tccattactt atcacctgaa caggcccggg 1617481 gcggcttagc cacaaaaaaa tcggatattt atgcgcttgg aatcgttcta tttgagcttt 1617541 taaccggccg tattccgttt gatggagagt cagcagtcag catcgccttg aagcatcttc 1617601 aagcggaaac tccttcggca aaaaggtgga atccatcggt cccccaaagc gttgaaaaca 1617661 tcatactcaa ggcaactgcc aaagatcctt ttcatcgcta cgaaacggct gaagacatgg 1617721 aagcagacat aaaaacagct tttgatgccg acagactcaa tgaaaagaga tttacgattc 1617781 aagaagatga agaaatgaca aaagcgatac ctatcattaa agatgaagaa cttgctaaag 1617841 ctgctggcga aaaagaagct gaagtgacaa ccgcacaaga aaacaaaaca aagaagaacg 1617901 gcaaaagaaa aaagtggccg tgggttttgc tcacgatatg cctcgttttt atcacagctg 1617961 gaattcttgc tgtcactgtt tttccgtcgc ttttcatgcc taaggatgtc aaaatacctg 1618021 atgtctccgg aatggaatac gaaaaagccg cagggctctt ggaaaaagaa ggtttacagg 1618081 ttgattccga ggtgttggaa atctcagatg aaaaaattga agagggcctg atggtaaaaa 1618141 cggatcctaa agcggatacc acagtcaaag aaggcgccac ggtcaccctt tataagagca 1618201 ccggaaaagc aaaaacggag atcggtgatg tgacaggcca aacggtcgac caagcaaaaa 1618261 aagcgttgaa ggaccaaggg tttaatcatg taacagtaaa tgaagtgaat gacgagaaaa 1618321 atgcgggcac tgtcattgac caaaatcctt cagcagggac tgagctggtc ccgagtgaag 1618381 atcaagtcaa acttacagtc agtatcggac ccgaagacat tacgcttaga gacttgaaaa 1618441 cctacagtaa agaagcagcg tctggatatc tggaagacaa cggattgaag cttgtagaaa 1618501 aagaagcata ctcagatgat gttccagaag gacaggttgt caaacaaaaa ccagcagcag 1618561 gtacggcagt aaagccggga aacgaagttg aagtgacatt ctctctcgga ccagagaaaa 1618621 aacctgcgaa aacagtgaaa gaaaaggtca agatccccta cgaaccagaa aatgaagggg 1618681 acgagcttca agtgcaaatc gcggttgacg atgcggatca cagcatctct gacacttacg 1618741 aagaatttaa gataaaagag ccgactgaac gaacgatcga actaaagatt gaaccaggcc 1618801 aaaaagggta ctatcaagta atggtaaaca ataaagttgt cagctacaaa accattgagt 1618861 atccgaaaga tgaataacaa ggagggaaaa tatgcctgag ggcaaaatta ttaaggcgct 1618921 aagcggcttt tactatgtac tggatgaatc agaggattca gataaagtaa tacaatgcag 1618981 aggaagaggc attttcagaa aaaacaaaat tacccctctt gtcggtgatt acgttgtgta 1619041 tcaagctgaa aatgacaaag aaggatatct aatggaaatt aaagaaagaa ccaacgagct 1619101 tatcaggccg ccaatttgca acgttgatca agcggtcctt gttttctcag cggttcagcc 1619161 ttctttcagc acggcattgc tcgaccgctt cctggttctc gttgaggcca atgatattca 1619221 gccgattata tgcattacta aaatggatct gattgaagat caagatacag aagatacgat 1619281 acaagcctat gcagaagact atcggaatat tggttatgac gtatacctta cctcctctaa 1619341 ggaccaagat agtttagcgg acatcatccc gcattttcag gataaaacaa cggtatttgc 1619401 cggtcagtcc ggtgttggga aatcctcgct tctcaacgcg atcagtccgg agctcggatt 1619461 aagaacaaac gagatttccg agcatttggg ccgcgggaaa cacacaaccc gccacgtgga 1619521 gctgattcac acgtccggag gtttggttgc agatacaccg ggattcagct cgcttgaatt 1619581 tacagacatt gaggaagaag agctgggcta taccttccct gatatcagag aaaaaagctc 1619641 ttcatgcaaa tttagaggct gtttacatct gaaagagccg aaatgtgcgg tgaaacaagc 1619701 tgttgaagac ggggaattaa agcagtatcg ctatgaccat tatgttgaat ttatgacgga 1619761 gattaaagac agaaagccga ggtattagca taatgataaa ggttgcacca tctattcttt 1619821 ccgctgattt tgccgcttta ggcaatgaga ttaaagatgt agaaaaaggc ggagccgatt 1619881 gtattcatat tgatgttatg gacggccatt ttgtcccgaa tatcacaatc ggtccgctga 1619941 ttgtagaagc ggtccggccg gtaacggatc tgccgcttga tgtccattta atgatagaag 1620001 agccggatcg ttatatcccg gcttttgcga aagcaggcgc agatatcctg tctgtgcatg 1620061 ctgaggcatg tccgcacctg caccgtacca tccagctcat taaagagcaa ggagtgaagg 1620121 ccggagtagt tctaaacccg catacccctg tacaagtcat cgaacatgtt ttcgacgatc 1620181 ttgatcttgt tcttttaatg acggtgaacc cgggcttcgg cgggcagaaa tttattcatt 1620241 cagtccttcc taaaataaaa gaggttaagc gaatggcgga tgaaaaagga aaaaaagatc 1620301 tgttaattga agtagacggc ggcgtcaaca aagaaaccgc tccgctcgtc attgaagcgg 1620361 gcgcaaattt actcgttgcc ggttcagctg tttatggcca gtctgaccgc aaaaaagcaa 1620421 tttctgaaat cagaggaagt aaataagcag ctttagaaaa gagctgggca tacaatagcc 1620481 taagctcttt ttcctgtatg cagagaaagg aatcagagat gaaaacaatt aatatcgttg 1620541 cgggaggccc gaaaaatctc attcccgatc taaccggcta tacggatgaa cacacgcttt 1620601 ggatcggtgt tgacaaaggc accgtcactc tcttagatgc cgggatcatt cctgttgaag 1620661 ccttcggaga ttttgacagc ataacggagc aagaacgccg gcgaatagaa aaagccgctc 1620721 ccgcccttca tgtgtatcaa gcagaaaaag atcaaacaga tttagacctc gcccttgatt 1620781 gggcgctgga aaagcagccg gatattattc agattttcgg cattacaggc ggcagagctg 1620841 atcatttttt aggaaacatt cagcttctgt ataaaggtgt aaaaacgaac ataaaaatta 1620901 ggctgataga caaacaaaat catattcaaa tgttccctcc tggtgaatat gatattgaga 1620961 aggatgaaaa taagcgatat atctccttca taccgttttc cgaagacata catgagctga 1621021 ccctgaccgg ttttaaatat cctctaaata attgtcatat tacgctcggt tcaacactat 1621081 gtattagtaa cgaactcatt cattcacgag gtactttttc gtttgcaaaa ggcatattaa 1621141 taatgataag aagcacggat taagcatgtg ctttcattca attgctgaaa acaatgaaca 1621201 aggcggttac gggacgttat aggaggggac aaaaatgaaa ttttacacca ttaaattgcc 1621261 gaagttttta ggaggaattg tccgggcgat gctgggctca tttagaaaag attaatgccc 1621321 aggggttcaa agccctcttt caccacataa aaacgcctgc cacatatcgg ggcaggcgtt 1621381 cattttgtta tacacgctca actttaccgg atttcaaagc tcgagcagat acatatactt 1621441 ttttaggttt tccgttcaca aggatacgaa ccttttgaag attcgcgccc caagtgcgct 1621501 tagaagcgtt cattgcgtga gaacggttat tcccagctgt tgttttttta cctgtgataa 1621561 cgcatttacg tgccatttgt ttccctcctc acttgcacaa aacatctact ttttaacatt 1621621 catataatct tagatgcttt cgatatggat actttaaata atttaccaca gctaaaaaac 1621681 gtttgcaact attgtttcat catctttcaa gaaaattcac ttgacatctt gcggaaacag 1621741 cagcgctata gtatatgtag aggtacggcc agcgattatt gcctggtctt ttcataatgg 1621801 aaaccatata gtagaatagc tgtaactcta tgcattcgaa ggaggaacta gtgtgtccat 1621861 tgaattaaga acgaagtacg gacagattga tatatctaat gaagtcatcg cgatggttgc 1621921 aggaggcgcg gcggttgact gttacggcat tgtcggcatg gcctctaaaa accagattaa 1621981 agacggactg actgaaatcc ttcggaaaga gaatttcagc aggggtgtcc aagttcgcca 1622041 agaaggagaa cagatacata tcgacatgta tatcattgtc agctacggca cgaaaatttc 1622101 tgaagtggca cataatgtcc aaacaaaagt aaagtacaca gtaaatcaaa ccatcggact 1622161 ggcagtggat tctgtcaata tttatgtcca aggcgtacga gtgacgaacc cgtagttagg 1622221 aggagtagga ttgtctatca gaacattaga cggcagaacc tttgccgaga tgattcttgc 1622281 gggagcgcag aatctgtctc aaaacgccag tgcagttgat gcactgaacg tgttcccggt 1622341 gccggacggt gatacgggaa caaatatgaa cctgtcgatg acttccggag caagagaagt 1622401 tgaacaaatg gatacggatg atatcgggaa ggtgggctcc gcgttatcta aagggctgct 1622461 catgggagca cgcggaaatt caggagttat cctatcccaa ttgttccgcg gatttagcaa 1622521 aaacattgaa acgaaaaaag aaattaatgc acttgagttt gccgctgcgc tgcaagcagg 1622581 tgtagacatg gcgtataaag ctgtcatgaa acctgtagag ggcaccattt taacagttgc 1622641 aaaagacgct gcaaaaaaag caatgatctt agcagaaaaa gaaaccgata tcactgcgct 1622701 gatgactgca gtgacagaag aagcagaggc gtctttaaac cgcacccctg aattgctacc 1622761 tgtcctaaag gaagtaggag ttgtcgatag cgggggcaaa ggcctgctct gtgtgtatga 1622821 aggtttcctt gcttcattaa aaggtgaaac tgtacctcag aaagcagttc ttccgtcact 1622881 tgacgacatg gtcagcgcag agcatcacaa gagcgcgcaa agcatgatga ataccgaaga 1622941 tattgaattt ggattctgta ccgaagtgat ggttaggctt gatcagacaa aaagagagtt 1623001 cgacgaaggc acgttcaggc aagacctcag ccagttcgga gattctctgc ttgtgattgc 1623061 ggatgaatcg ctggcgaagg ttcatattca tgctgaagag ccgggaaacg tgttaaacta 1623121 cgcccagcat tacggtgaat tgatcaaaat aaaaatagaa aatatgagag aacagcatac 1623181 ctctatcatc agtcaagaaa gcaaacctgc agacaacgaa acaccgccgg caaaacagcc 1623241 gtatggcatt gtgactgtag cgatgggaga aggaattgca gacctattta aaagcattgg 1623301 cgcttctgtt gtgattgaag gcggccagac catgaaccca agcactgagg atattgttga 1623361 tgccgtgaag tctgtaaatg cagatacggt atttatcctg cctaacaact ccaacattat 1623421 catggctgct aaccaagcgg ccagcgtagt ggatgaacag gtttttgtca ttcctgctaa 1623481 aacggttccg caagggatgt cagctctgct ggcttttaac ccggatcaag aagctgaagc 1623541 gaacgaggcc aatatgctaa gcgccattca gcaagtaaaa agcggacagg tgacgttctc 1623601 agtcagagat actcatattg acggtaaaga cattaaaaaa ggcgacttta tgggcattct 1623661 gaatggaacg attatcggca cttctgaaaa tcagctgtca gccgcgaaaa tgctgctgtc 1623721 agaaatgatc ggagaagatg atgaaatcgt gaccattcta tatggtgagg atgcgtctca 1623781 ggaagaagct gagcagcttg aagcgtttct cagtgaaaag tacgaggaga ttgaggttga 1623841 gatccacaat gggaaacagc ctctgtattc gtatatagtt tcagcagaat agaagggcaa 1623901 tttgcccttc tattcttatg tctgctttta agtgcggcag cgctgtaacg cgcccgcttg 1623961 ccattttata tctgatcaat tagtctagaa gcaaagcgct aataagctct ggttcataag 1624021 gaggaatagc atgaaataca gaagcgtttt tgatattatc ggcccggtta tgatcggtcc 1624081 gtccagctct catacagcgg gagctgctag aatcgggaga gtggccagaa gtttatttgg 1624141 cagagagcct gagcgcatca ttgtatcttt ttacggctcg tttgcggaaa cgtataaggg 1624201 ccacggcaca gatgtcgcga ttatcggcgg attgcttgat tttgatacat tcgatgaacg 1624261 gattaaaacc gctatacaaa ttgcagaagc taaaggaatt gatatagagt ttcgggtaga 1624321 agacgcagtc ccggtccacc cgaacacagc aaaaatcacc atttctgatg aaaagggtga 1624381 gctggaactg acgggtattt cgattggcgg aggaaagatt gaaatcacag aattgaatgg 1624441 ttttgagctc cggctgtcag gaaatcatcc ggccatatta gttgttcata atgacaagtt 1624501 tggcacaatt gccggtgttg ccaatgttct ggcgaaattt tcaatcaacg taggacatat 1624561 ggaagtagcc cggaaagata tcggccagct tgcgctgatg acaatagagg tcgatcaaaa 1624621 tattgacgac cacattctcg acgagctgtc gaagctgccg aatattattc aagtgacaaa 1624681 gattgctgac tagcgaaaag ggtcaggagg agccagttat gtttcgtaat gtaaaagaat 1624741 taattgagat tactaaagaa aaacaaatat tgatctctga tgtgatgata gctcaagaga 1624801 tggaagtaac agaaaaaaca aaagaggaca tttttcagca gatggatcat aacctgtctg 1624861 ttatggaagc ggcggttcag aaaggactcg agggagttac gagccaaacg ggcttaacag 1624921 gcggagatgc cgttaaattg caggcctata ttcgatcagg aaaaagcctg tctggcccgc 1624981 tgattttaga tgctgtatcg aaagccgttg caacaaatga agtaaatgca gccatgggaa 1625041 ccatctgtgc gacaccgact gcaggttctg ccggtgtggt gcccggtacg ttatttgctg 1625101 taaaagaaaa gctgaatcca acaagagaac aaatgatccg ctttttgttt acagccgggg 1625161 ctttcggatt tgtcgtggcc aataacgcaa gcatttccgg cgccgccgga ggatgtcagg 1625221 cagaggttgg atcagcttca ggcatggcgg ctgcggctat tgttgaaatg gcaggaggaa 1625281 cacccgaaca aagcgcggaa gccatggcca ttacattaaa aaatatgcta ggcctcgtgt 1625341 gcgaccctgt tgcagggctt gttgaggtgc cttgcgtgaa acggaatgcg atgggcgcgt 1625401 caaatgcgat gattgctgct gatatggcat tggcgggcat tacaagccgt attccatgtg 1625461 atgaggttat cgatgccatg tataaaatag gccaaacgat gccaactgca cttagagaaa 1625521 caggccaggg cggtttagcg gcaacaccga caggaagaga attagagaaa aaaattttcg 1625581 gaggagcgct aggttcacgt gaaacaacat cagcaaacta gtatagctaa cattaagggt 1625641 attgggccgg aaacagaaaa aacattgaat gaactcggta tttatgacat ttctgatctt 1625701 ctgaattatt tcccttatcg ctatgatgac tacgagctga gggatttaga agaagtaaag 1625761 catgatgaaa gagtcacagt cgaagggaag gttcattcag agccttctct tacctattac 1625821 ggaaaaaaac gaaacaggct gacattcagg cttctggtcg gccactattt aatcacagcc 1625881 gtatgtttta accggcctta tttgaagaag aagctttcgc tcggctctgt ggtgacggtt 1625941 tcaggtaaat gggacaagca ccgccaaacc atctctgttc aggagttgaa aaacgggccg 1626001 catcaagaag acaaaagcat tgaaccagtg tattctgtga aagaaaatgt taccgtcaaa 1626061 atgatgaggc gctttattca gcaggcgctg acccaatatg cagactcact tcctgatcct 1626121 cttccggaaa agctaagaaa aagctataaa ctgcctgact attatcaagc gttaaaagca 1626181 atgcaccagc ctgaaacaag ggaagcatta aagcttgcca gacggcggtt tgtttatgaa 1626241 gaatttttgt tgtttcagtt gaaaatgcag gcgttccgaa aggcggaaag agagcagaca 1626301 caagggatac ggcagcgttt ttcaaacgaa gaactcatga gatttatcaa aagcctcccg 1626361 tttcccctca caaacgccca gtcacgcgtt cttcgcgaaa taacagcaga catgtcttct 1626421 ccatacagaa tgaaccgtct tcttcaaggg gacgttggat caggaaaaac ggcagtcgcc 1626481 gccattgcac tgtatgccgc gatcctatcc ggataccaag gagcgctcat ggtgccgaca 1626541 gaaattctgg ccgagcagca tgctgattcg ctcgtttcgc tatttgaaaa atgggacgtc 1626601 agcgttgctc ttttgacaag ctctgttaaa ggaaagcggc gaaaagaact gcttgagcgt 1626661 cttgcggcgg gtgagattga tattcttgta ggaacccatg ctttaatcca agacgaggtg 1626721 gagtttaagg cgttgagtct cgttattact gatgaacagc acagatttgg agttgagcag 1626781 cgcaaaaagc ttcggaacaa agggcaggat cccgatgttc tctttatgac agccactcca 1626841 atcccaagaa cattagcgat cacagtattc ggtgaaatgg atgtatctgt cattgatgag 1626901 atgccggctg gacgaaagcg aattgaaacc tattgggtaa aacatgacat gcttgatcgt 1626961 attttggcat ttgtcgaaaa agaattaaag caaggcaggc aggcttatat catctgtccg 1627021 ctgattgaag aatcagataa gcttgatgtg caaaacgcca ttgacgtgta caatatgctt 1627081 tctgatattt ttcggggaaa atggaatgtc ggccttatgc atggaaagct gcattccgat 1627141 gaaaaagatc aggtcatgag agaattcagc gcaaatcact gtcaaattct cgtatcaacc 1627201 actgttgtgg aggttggcgt aaatgttccg aatgcaacaa ttatggtgat ttatgacgcc 1627261 gaccgtttcg gactatcaca gcttcaccag ctgcgcggcc gtgttggacg gggtgagcat 1627321 caatctttct gtattctgat ggctgatcca aaatcagaaa cagggaaaga acggatgagg 1627381 atcatgtcgg agaccaatga cggtttcgag ctgtctgaaa aggatctgga actgagaggt 1627441 cccggtgatt tcttcgggaa aaaacaaagc ggaatgccgg aatttaaagt ggcggacatg 1627501 gttcatgatt acagagcgct tgaaacggca aggcaggatg ctgcgaatct tgtggcttct 1627561 gacgcgttct ggaaggagcc ggaatacgct gtgttaagag atgaattgct gaagagcgga 1627621 gtaatggacg gggaaaaatt aagctgagta tcagaagttt ttggtgttca gccagaaaca 1627681 atcgttgcat tccaatctat gaaattatat actactatta gtacctagtc ttaattgtcc 1627741 ggatggtgtt tagatatgag aagaaataag agagaacgcc aggaattact tcagcagacg 1627801 attcaagcaa ccccctttat tacagatgaa gaactagcgg gtaaattcgg ggtgagcatc 1627861 cagacgatac gtttggaccg cttagagctt tccatacctg aactgagaga aagaattaag 1627921 aacgtggcag agaaaacact tgaggacgaa gtgaagtccc tgtcacttga tgaagttatc 1627981 ggagaaatta ttgaccttga gctggatgat caggcgatat ccattttaga aataaaacag 1628041 gagcacgtgt tcagccggaa tcagattgcg agaggacacc atttatttgc acaggcgaat 1628101 tctttggccg ttgcagtcat tgatgacgag ctggcgctga ctgcaagtgc agacatccgc 1628161 tttacaagac aggtaaagca gggtgaacgt gtcgtagcaa aagcgaaagt gacggctgtc 1628221 gaaaaagaaa aaggaagaac ggttgtcgaa gtgaacagct acgttggcga agaaattgtt 1628281 ttttctggac gctttgacat gtatcgttca aaacattcat aaaggtggag catgcatgag 1628341 aatagctgta gatgcaatgg gaggagacca cgctcccaaa gctgttattg acggagttat 1628401 aaaaggtata gaggcatttg atgatctcca tatcacactt gtcggtgaca aaacaacgat 1628461 agaatcacat ttaacaacta catcagatcg catcacggtg ctgcacgcag atgaagtgat 1628521 tgagcctacg gatgaaccgg tccgtgccgt gcgaagaaaa aagaactcat ctatggttct 1628581 tatggcgcag gaggttgcgg aaaacagagc tgacgcctgc atttcagcgg gaaataccgg 1628641 tgcattaatg acagccggtc tctttattgt cgggagaatt aaaggaattg accgtccggc 1628701 gcttgctccg acacttccga ctgtttcggg agacggattt cttctccttg atgtcggcgc 1628761 caatgtcgat gccaaaccgg agcacctcgt tcaatatgcc atcatgggtt ctgtttattc 1628821 tcagcaagtg cgcggtgtca cttcaccgag agtcggactt ttaaatgtcg gaacagaaga 1628881 taaaaaagga aacgaactga cgaagcagac gtttcaaatt ttaaaagaaa cagcaaacat 1628941 caattttatc ggaaacgtgg aagcgcgaga ccttttagat gatgtggcgg atgttgtagt 1629001 aacagacggc tttaccggga atgttacact caaaacgctg gaaggctctg cgttgtcaat 1629061 ttttaaaatg atgagagacg taatgacgtc tactttgaca tccaagcttg cagcagctgt 1629121 gctgaaacca aaattgaaag aaatgaaaat gaaaatggag tattcgaatt atggcggagc 1629181 aagtcttttt ggcttaaaag cgcctgtgat caaggcgcac ggctcttcag attcaaatgc 1629241 tgtattccat gcgattcggc aagcaagaga gatggtcagc caaaatgtgg ctgcgctcat 1629301 tcaggaagaa gtgaaagaag aaaaaacaga tgagtagtct ggaggttttt acatcatgag 1629361 taagattgca tttttattcc cgggtcaggg atcacaattt atcggcatgg gaaaagagct 1629421 ttatgagcag gtgcctgctg caaagcgtct gtttgatgaa gccgatgaaa cgttggaaac 1629481 aaaactcagc tcgcttattt ttgaggggga tgctgaagaa ttaacactta catacaatgc 1629541 gcagcctgct ttgcttacga caagcatcgc tgttcttgag aaatttaaag aatctggcat 1629601 tacacctgat ttcacagcag gacacagcct tggtgaatat tctgcactgg ttgcggctgg 1629661 cgctctgtct ttcaaagatg ctgtttatac tgtcagaaag cgcggagagt ttatgaatga 1629721 agcggtgccg gctggcgaag gagcaatggc tgcgattctc ggcatggatg ctgaagcatt 1629781 aaagcaagta accgataaag tcacagagga aggcaacctt gtacagcttg cgaatctcaa 1629841 ctgtcctggc caaatcgtca tttccggaac agctaaaggg gttgagcttg catctgaact 1629901 ggcaaaagag aacggcgcaa aacgcgcaat tccgcttgaa gtaagcggtc cgttccattc 1629961 tgaactgatg aaaccggctg ctgaaaagct gaaagaggta ttggacgcct gtgacataaa 1630021 agacgctgac gttccggtca tctcaaatgt ttctgctgac gtgatgactg aaaaagcaga 1630081 tatcaaagaa aaacttattg agcagcttta ctctccggtt cgttttgagg aaagcattaa 1630141 caagctgatc gcagagggtg ttacgacttt tattgaaatc ggtcccggaa aagtgctttc 1630201 aggccttgtg aaaaaagtga atagacggtt aaaaacaatt gctgtatcag atccggaaac 1630261 gatcgagctg gcaattcaaa cgcttaagga ggagaatgat aatgcttaat gataaaacgg 1630321 ctattgtcac tggcgcatcc cgcggaatcg gccgctcaat cgcccttgat ctggcaaaaa 1630381 gcggagcaaa tgttgtcgtg aactactccg gcaatgaagc gaaagcaaat gaagtggtag 1630441 atgaaatcaa atcaatgggc agaaaagcaa ttgctgtaaa agcggatgta tcaaatcccg 1630501 aagatgtaca aaacatgata aaagaaacat tgtctgtttt ttctacgatt gacattctgg 1630561 ttaataatgc gggaattaca agagacaatc tcatcatgag aatgaaagaa gacgaatggg 1630621 atgacgtcat taacattaac ctgaagggtg ttttcaactg cacaaaagct gttacaagac 1630681 aaatgatgaa acagcgttca ggccgcatta ttaacgtatc gtctatcgtc ggcgtcagcg 1630741 gaaaccctgg acaagccaac tacgtggctg caaaagccgg cgtcatcggt ttaaccaaat 1630801 cttctgctaa agagctcgcc agccgaaata ttacggtaaa cgcaatagcg ccaggattta 1630861 tctcaactga tatgacagat aaacttgcaa aagacgttca agacgaaatg ctgaaacaaa 1630921 ttccgctcgc gcgctttggt gaacctagcg atgtcagcag tgttgtcacg ttcctagctt 1630981 cagagggagc tcgttatatg acaggccaaa cgcttcatat tgacggcgga atggtgatgt 1631041 aagttttttc tcgaaaattt catcgtagtt tctctagttt tttaaaaacg aatccactat 1631101 aatacttgag gggaggtgaa ttgctatggc agacacatta gagcgtgtaa cgaaaatcat 1631161 cgtagatcgc cttggcgttg atgaagcaga cgtcaaactt gaagcttctt tcaaggaaga 1631221 cttaggtgct gattccctag atgtagttga gcttgttatg gaacttgaag acgagtttga 1631281 tatggagatt tctgacgaag atgctgaaaa gattgcaaca gtcggcgacg ctgtgaacta 1631341 catacaaaac cagcaataag ctgatgctaa aagtcccgcc gaaacgcggg gctttagccc 1631401 tttattcgtg cagttattac agcatgccgc ttttacgcgc gctgtatccg gtttagtcag 1631461 agaagcgcgg tgaacctgat gtgcctatgg aggttactat gtcaaaacac tcacattata 1631521 aagataaaaa aaagttctat aaaaaagtag aacaatttaa agagtttcaa gaacggattt 1631581 cggttcactt tcaaaatgaa aagcttttgt atcaagcatt tacacattca tcttatgtga 1631641 atgagcatcg gaaaaagccg tatgaagata atgaaaggct tgaattttta ggtgacgctg 1631701 ttttggaact gacgatctcc agattcttat ttgccaaata cccggctatg agtgaaggag 1631761 atttgacgaa attgagagcc gcaattgttt gcgaaccgtc tctcgtttca ttggctcacg 1631821 agctgtcatt cggcgatctt gtcctgttgg gtaaaggcga ggaaatgaca ggcggaagaa 1631881 agcgtcctgc tctattggcg gatgtttttg aggcatttat cggagccttg taccttgacc 1631941 aaggattaga gccggtcgaa agtttcttaa aagtttatgt gttccctaaa attaacgatg 1632001 gtgctttttc tcatgtgatg gatttcaaaa gccagctgca ggaatacgtg cagcgggacg 1632061 gcaaaggctc tctggagtat aaaatctcca acgaaaaagg acctgcgcac aaccgtgaat 1632121 ttgaagccat cgtatctcta aaaggtgaac cactcggagt cggaaacggc cgttcaaaga 1632181 aagaagccga acagcacgct gctcaggaag ctttagctaa attgcaaaaa caccatacga 1632241 aacaataaaa tcccccttat gactcagggg gatttcagta tgtatgccgt cttatttgac 1632301 caatgtttat gatagaattg aaatacttat tacataagga ggatcgctat gttcctcaaa 1632361 cgtttagacg ttataggatt taaatcattt gcagaacgga tttccgtaga cttcgttaaa 1632421 ggcgtgacag cagttgtcgg gccgaacgga agcggaaaaa gcaacatcac ggatgccatt 1632481 cgctgggttc tcggcgaaca atcggcacgc tctcttcgcg gcggaaaaat ggaagacatc 1632541 atttttgctg ggagtgattc aagaaagcga ttaaatctag ctgaagttac gcttactctt 1632601 gataatgatg atcatttctt gccaattgac ttccacgagg tgagtgtcac aagacgtgtg 1632661 tacagatcag gtgagagtga gtttctgatt aacaatcagc catgccgctt gaaagatatt 1632721 attgatttat ttatggactc tgggcttggt aaagaagcat tttctattat cagccaaggg 1632781 aaagtggaag agatcctgag cagcaaagcg gaggatcgcc gcagtatctt tgaagaagcg 1632841 gccggggtgc ttaaatataa aacgagaaag aaaaaagcag aaaataaact gtttgagaca 1632901 caggacaatc taaatcgggt agaagatata ttacatgagc ttgaaggaca ggttgaacct 1632961 cttaaaattc aagcttcaat agcgaaagac taccttgaga aaaagaaaga gctggagcat 1633021 gttgaaattg cgctgactgc ctatgatatc gaagagctgc atggtaaatg gtcgactctt 1633081 aaagagaaag tgcagatggc aaaagaagaa gagcttgctg aatcgtctgc tatttctgcg 1633141 aaagaagcaa agattgagga tacaagggac aaaatacaag cgcttgatga gtcagtagat 1633201 gagctccagc aagttttact ggtaactagt gaagagctgg aaaagcttga aggccgtaaa 1633261 gaagtcctga aagaacgaaa gaaaaacgct gtgcaaaacc aagaacagct tgaagaagcc 1633321 atcgttcagt tccagcaaaa agaaacggtt ctgaaagaag agctttcgaa gcaggaagct 1633381 gtcttcgaaa cgcttcaggc tgaggtgaag cagttaaggg cgcaagtaaa agaaaaacag 1633441 caggctctca gtcttcacaa tgaaaatgtc gaagagaaaa tcgagcagct gaaaagtgat 1633501 tattttgagc tgttaaacag ccaggcttcg atacgcaacg aactccagct tcttgatgac 1633561 cagatgtccc aatccgctgt cacattgcag agacttgcgg acaacaatga aaagcacctg 1633621 caggaacggc atgatatttc tgcgcgtaaa gccgcatgtg aaacggaatt tgcccgaatt 1633681 gagcaggaga ttcacagtca agtcggtgca tatcgtgata tgcagacaaa atatgagcag 1633741 aaaaagcgcc aatacgaaaa aaatgaatcc gctctgtatc aggcatacca atacgttcag 1633801 caagcgagat caaaaaagga catgcttgag acgatgcagg gagatttctc cggcttttat 1633861 caaggtgtta aagaagtgct gaaagcgaaa gagcgccttg gcggaattcg cggagcggtt 1633921 cttgagctga tttctacaga acagaagtat gaaacggcca ttgaaatagc gctcggcgct 1633981 tctgctcaac acgtcgtgac cgacgatgaa caatctgccc gcaaagcgat tcaatattta 1634041 aagcagaatt ccttcggccg ggcgacgttt ctgcctcttt ctgttattag agaccgccag 1634101 cttcaaagcc gtgacgcgga aacagccgcc cggcattcat catttctcgg ggttgccagt 1634161 gaacttgtca catttgatcc tgcgtatcga agcgtcatcc agaatcttct tggaaccgtt 1634221 ctgatcacag aggacttaaa gggtgcaaac gagcttgcga agcttctcgg gcaccggtac 1634281 cgcatcgtaa cccttgaggg agatgttgtg aaccccggtg gttcaatgac gggcggcgcg 1634341 gttaaaaaga aaaataactc cctccttgga agaagccggg agctagaaga tgtgacgaaa 1634401 cggctcgctg aaatggaaga gaaaacggca ctgcttgaac aagaggtcaa aacccttaag 1634461 cactccattc aggatatgga gaaaaaactg gctgacttaa gagaaaccgg ggaaggctta 1634521 aggttaaagc agcaggatgt gaaaggccag ctgtacgaac ttcaagttgc cgagaaaaat 1634581 atcaataccc atttagagct ctatgatcaa gaaaaatctg ctctgtcaga aagcgatgaa 1634641 gagagaaaag tgcgcaaacg caagcttgaa gaagagctct ctgccgtatc tgaaaagatg 1634701 aaacagcttg aagaggacat agacagactg acaaaacaaa aacaaacgca atcctcaacg 1634761 aaagagtctc tctccaacga gctgactgag ctgaagatcg cagcggccaa aaaagagcag 1634821 gcttgcaagg gggaagagga caaccttgcc agattaaaga aagagctcac tgaaacagag 1634881 cttgcgttaa aagaagcaaa agaagactta agcttcttaa cgtcagagat gtcatctagc 1634941 accagcggcg aagaaaagct ggaagaagca gcaaaacata aattgaatga caaaacgaaa 1635001 acgatcgaac tgattgcatt aaggcgcgat cagcgcatca agcttcagca tgggcttgat 1635061 acgtatgagc gtgagctgaa agaaatgaaa cgcctgtata aacaaaaaac aacgctctta 1635121 aaagacgaag aagtcaaact tggacgaatg gaagtcgagc ttgataattt actccaatac 1635181 ttacgggagg aatacagctt gtcctttgag ggggcaaaag agaaatatca gcttgaaact 1635241 gatccagagg aagccagaaa gcgcgtgaag ctgattaaac tcgcaattga agagctgggt 1635301 accgtgaacc tcggaagcat agatgagttt gagagggtca acgaacggta caagtttctg 1635361 tcggaacaaa aagaagattt aacagaagcg aaaaatacct tgttccaagt gattgaagaa 1635421 atggatgaag aaatgacgaa gcgctttaac gacacattcg tccaaatccg ctcacacttt 1635481 gatcaagttt tccgctcctt attcggagga gggcgagctg aactgaggct caccgatcct 1635541 aacgatctgc ttcattcagg agtcgagatt atcgctcagc cgccggggaa aaagctgcaa 1635601 aacttaaacc tcctgtcagg cggagagcgt gcgcttactg ctatagcgct cttattctca 1635661 atcctaaagg ttcgtccagt gccgttttgc gtccttgacg aagtagaggc tgcgctcgac 1635721 gaagcgaatg tgttccgatt tgcgcagtat ttaaaaaaat acagcagcga tactcagttt 1635781 attgtgatta cccacagaaa aggaacgatg gaggaagcgg atgtgcttta tggcgtaacc 1635841 atgcaggaat ccggtgtttc caaggtaatt tcagttaagc tggaagaaac aaaagaattc 1635901 gttcagtaac gaggaaagag gttaaaagat gagctttttt aaaaaattaa aagagaaaat 1635961 cacaaaacag acagattccg tatctgaaaa gtttaaggat ggccttgaaa aaacaagaaa 1636021 ctcctttcaa aacaaagtga atgatcttgt atcccgttac cgtaaagtgg atgaggattt 1636081 cttcgaagag cttgaagagg ttcttatcag cgcggatgtc ggttttacaa ccgttatgga 1636141 attaatagat gagctgaaaa aagaagtcaa acgcagaaat attcaagatc caaaggaagt 1636201 ccagtcagtg atttctgaga aactggtcga gatttataac agcggagatg agcaaatttc 1636261 agaactgaac atccaggatg ggcgtttaaa cgtaatcctt ctggtaggtg taaacggcgt 1636321 cgggaaaaca acaacgatcg gaaagcttgc tcataaaatg aaacaagaag gaaaatctgt 1636381 tgtacttgcc gccggagaca cttttagagc gggagccatt gaacagctgg aagtatgggg 1636441 agagcgtaca ggagtgcctg tcattaagca gacggcagga agcgatccgg cggctgtcat 1636501 ctacgatgct gttcatgctg cgaaagcaag aaatgccgat gtattaattt gtgatacggc 1636561 agggcgtctc caaaacaaag taaatctcat gaaagagctt gaaaaagtaa aacgtgttat 1636621 cgaaagagaa gttcctgaag ctccgcatga ggtgctgctt gcccttgatg ccacgaccgg 1636681 ccaaaatgca atggctcagg caaaagaatt ctctaaagca acaaatgtta ccggcattgc 1636741 tttaacgaag cttgacggta cggcaaaagg cggtatcgtc cttgcgattc gcaacgagct 1636801 tcacatcccg gttaaactag tcggtttagg agaaaaagtt gatgaccttc aggaatttga 1636861 tccagaatcc tatgtgtacg gactcttttc agatttagtg gaaaaagccg acgattaaga 1636921 aaaaggcccc aacatcttgg ggcctttttc ttttttatct tcttacttga taggcgaaat 1636981 gataaaggct gttatcagtg gataccagtc ttgactcacc agaaaaaact ctgaatggga 1637041 tgatgtcata gtaatgaacg gaaacagatg tgtaatacgt atagtaacca gcagctggcc 1637101 ccaaatacat tggaacctca aatgttccgt ttgcatcagt cgttcctgaa gcagtttgtg 1637161 ttgtgtttcc gaccttcgtg tccgcttcaa atcttacggg cgcgtttggc actggctgtc 1637221 cgttttggtc gagtaatttg ccgcttactg taatattgta cttgactcgc caatattgac 1637281 cttgtccgta attgatttta ccgtataccc ctccatctgt gctgatattt gtgattgagg 1637341 ccttataagg tgcctcagca gcgtctgctt gctgtgccgg gaaacctatt gtaaacaggg 1637401 ctgccagaca taacataaac aataaaccga tttttttcat aaaaatcctc cttaaaatag 1637461 ggttcatata caatatcgga ataaattgga tgatatttag cgtattttgg aaaagttaat 1637521 cgccgctttg acaagataaa aacttgacag tgtcattaaa accgtgtaaa ctaagttatc 1637581 gtaaagggat ttgacttaac aaaggggaga gctcaaatgt cactcgaaaa gacaacgaga 1637641 atgaattatc tgtttgattt ttatcagtcg ttgttgacgt caaaacagaa gagctatatg 1637701 tcgctttatt atttggacga tttctcccta ggcgaaatag ccgaagaata tgaggtttca 1637761 agacaagctg tttatgataa catcaaacga acagaagcaa tgcttgaaca atatgaagaa 1637821 aagctgctcc ttttgaaaaa gtttcaggag cgtaaagaga tgtttaataa gctgaaggag 1637881 cttgcttccg gttcaaaaga agaggaagaa attacagctc tgattgaagc gcttgagaaa 1637941 ttagattagg aggcggcaaa ctatggcatt tgaaggatta gccgaccgac tgcagcagac 1638001 gatttctaaa atccgcggaa aagggaaagt cagcgaacaa gatgtaaaag agatgatgcg 1638061 tgaggtccgt cttgcgctgc ttgaggctga cgttaacttt aaagtagtca aggattttgt 1638121 caaaaaagta agtgaacgcg ctgtaggcca agacgtcatg aaaagtctga cgcccggcca 1638181 gcaggtcatt aaagttgttc aagaggaact gactgagctg atgggcggcg aagagagcaa 1638241 aatcgccgtc gcaaaaaggc cgccgactgt tattatgatg gtcggtctcc aaggtgccgg 1638301 taaaacgaca acaagcggta agcttgcgaa tctgctgcgc aaaaagcata atcgcaaacc 1638361 gatgctggtt gctgccgata tttaccgccc agccgcaatt aagcagctgg aaacactcgg 1638421 caaacagctt gatatgcctg ttttctctct tggcgatcag gtcagtcctg tagaaatagc 1638481 taaacaggct attgagaaag ccaaggaaga acattatgac tacgtcattt tggatacggc 1638541 agggcgcttg catatcgacc atgaactgat ggatgaactg accaacgtca aagaaatcgc 1638601 gaatccggaa gaaattttcc tggttgtcga ttcaatgacc ggtcaggacg ctgtgaatgt 1638661 tgccaaaagc tttaatgaac agctcggttt aaccggtgtt gtgttgacta agctggatgg 1638721 agacacacgc ggcggggctg cgctttctat tcgcgctgtc acaaacacgc caattaagtt 1638781 tgcaggtttg ggcgaaaagc ttgatgcgtt agagccgttc catcctgaac gcatggcatc 1638841 aaggattctc ggcatgggcg acgtgctgac attgattgaa aaagcacagg ccagcgttga 1638901 tgaagacaaa gccaaagagc tggaacaaaa aatgagaacg atgagcttca cattggacga 1638961 ttttctggag cagctcgggc aagtcagaaa catggggccg cttgatgagc ttctgcaaat 1639021 gatgccgggt gcaggtaaaa tgaagggcct gaaaaacatc caagttgatg aaaaacagct 1639081 gaatcatgtg gaagcaatca tcaaatcaat gactgttctt gaaaaagaac agccggatat 1639141 tatcaatgcc agccggcgga agcggattgc aaaaggaagc gggacatccg tacaggaagt 1639201 caaccgtctg cttaagcagt ttgatgaaat gaaaaaaatg atgaagcaga tgacaaacat 1639261 gtcaaaaggc aagaaaaaag ggtttaagct accttttatg taatcggtta tacatgataa 1639321 aaccgttgtt aagaaaaaac actttacaaa cacttttatc attgttaata tactatcttg 1639381 ttgaaatatt ttcggaggtg ctagtaaaat ggcagtaaaa attcgtttaa aacgtatggg 1639441 agcaaaaaaa tctcctttct atcgtattgt tgtagcagat tctcgttcac cacgtgacgg 1639501 ccgtttcatc gaaacagtcg gaacttacaa cccggttgca aaaccagcgg aagtaaaaat 1639561 tgacgaagag cttgctctta aatggcttca aactggagcg aaaccatctg atacagttcg 1639621 caacttgttc tctagccaag gaatcatgga aaaattccac aacgctaaac aaggcaagta 1639681 atgactgatc aacacttgga agatttgatt gtccacattg tgacgccgct tgttgatcat 1639741 ccagatgaca ttcgcgtcat aagagaagaa accgatcaaa agattgcgct gcgcttatct 1639801 gtccataagt cagataccgg taaagttatc ggaaagcaag gccggactgc aaaagcgatt 1639861 cgaacagctg tatttgcagc tggcgtacag tcttctaaga aagttcaatt tgaaatattt 1639921 gactaaaagg gagagggccg gcacctcccc tttttttaca cgcaaaaaaa gggtaaactg 1639981 atagaagctt aggcaaaata gaaaagcctg gacgagtaaa agttttaaaa gcggggagct 1640041 tggtgcgatg caaattattc accgtgtagc cgttatgcaa gtcttaaccg agcgcagtaa 1640101 agaaaagctt ttagcttctt ttgctgagaa gaaacaaatg cttgaacgag aatgcagcca 1640161 gctctatttt cagcttagaa aacatgagaa agaacagcaa aaccctaata tgattgaaca 1640221 atttaaaaag gcaatagaaa agcgaaaaga tgatataaaa atcattgatt ttcaaattgc 1640281 tcaagtacat acattgccgc ttggcagtga gttgaaagaa aaggaagtcg atgcgctgct 1640341 gacgattgaa gccggggatg actggcatga gaaaacagca gcgaacacca tcgtcataaa 1640401 agacggaaaa gtaattgaaa ttcgccagag gtgatcatat gacaaagcga tggtttaatg 1640461 taggcaaaat cgtaaatacc cacggaatca aaggcgaagt gcgggtgatt tcaaaaacag 1640521 attttgccga agaacgatac aagccgggaa acacgctgta tttgtttatg gacggccgta 1640581 acgaaccagt ggaggtaacg gtaaacacac atagactgca taagcaattt catctcctgc 1640641 agtttaaaga aagacaaaac ctaaatgaag tagaagagct gaaaaacgca atcattaaag 1640701 ttcctgaaga agaattagga gagctgaatg agggtgaatt ttatttccac gaaattattg 1640761 ggtgtgaagt atttactgaa gaaggcgaac tcatcggaaa ggtcaaagaa attttgacgc 1640821 ctggagccaa tgacgtttgg gtcatcggac gaaaaggaaa aaaagacgca ctcattcctt 1640881 acattgaatc agtggttaaa catatcgatg tcagggaaaa gaaaattgag attgaactca 1640941 tggaagggtt aatagacgaa tgaaaatcga ttttttgacg ctgtttcccg aaatgtttga 1641001 aggcgtgctc ggctcatcga ttcttcaaaa agcccaggaa aaagatgcgg tgcagtttca 1641061 agtcgtaaat ttccgagagt actctgataa caagcacaat actgttgatg attatcctta 1641121 tggcggcggg gcaggcatgg ttctcaagcc ccagcctgtt tttgacgcgg tcgaggacct 1641181 gacatcaaag gcagccgctg ctccgcgtat tatcctcgta tgcccgcaag gtgagcgttt 1641241 tacccaaaaa aaagccgaac aattagctaa ggaagagcat ttgctgttca tttgcggcca 1641301 ctatgaaggc tatgatgaac gcattcgcga gcacttggta acggatgaaa tatcaattgg 1641361 cgactttgtt ctgacgggcg gtgagctccc tgcaatgatg atcgcagaca gtgtggtcag 1641421 actgcttccg ggtgtactgg gtaaagaggc ttcccatatt gaggattcct tcagcaccgg 1641481 acttttagag cacccgcatt atacaagacc ggcagattac aaaggtttaa aagtgcctga 1641541 aacactcttg tcaggaaacc atgcaaaaat tgaagaatgg cggaataaag aatcgatcag 1641601 aaggacctac ctaagacgtc cggatctgtt gaaagaccac ccgcttacag agcagcaaag 1641661 aaagtggatt tctgaatggg aaaaagaata gattttattg cataggctat gaaattgtga 1641721 taagatacta cttgtggctt aagcgggctt atccgctgca agcttgaaaa cgatgttccg 1641781 ctgtgccggt ttttgtggcc aagagcatct gttggaagga gttgaaaacg atgcaaaaac 1641841 taattgaaga tatcacaaaa gaacagcttc gtactgatct tcctgcgttc cgtcctggtg 1641901 acactttacg tgtacacgtt aaagttgttg agggtaaccg tgagcgtatc cagatctttg 1641961 aaggtgttgt gattaagcgt cgtggtggtg gaatcagcga aacgttcaca gttcgtaaga 1642021 tttcttacgg tgttggcgtt gaacgtactt tcccagtaca cacaccaaaa atcgcgaaaa 1642081 tcgaagttgt acgttacggt aaagtacgcc gtgctaaact ttactacctg cgtgaacttc 1642141 gcggaaaagc ggctcgtatt aaagagatca gacgataatg ataacgaacg aaaagagctt 1642201 gttacctgta acaagctctt tttttataca gaatttgaaa atgccggaca ggcatcgtaa 1642261 aatacataaa ggacaacaat gaatcatgca tactgaagat aaaggcggtg ttcgtgtcac 1642321 atgacaattc aatggttccc gggccatatg gcaaaagcaa gaagggaagt aaccgaaaaa 1642381 ttaaaattaa tcgatatcgt atatgaattg gtagatgcca gaattccaat gtcatcaaga 1642441 aacccaatga ttgaagatat tctaaaaaac aagccgcgaa ttatgctgtt aaacaaggct 1642501 gacaaagcag atgcggcagt tacacagcag tggaaagagc actttgagaa ccaggggatc 1642561 cgctctctgt ctattaattc tgtaaatgga caagggttaa atcaaattgt gcctgcatca 1642621 aaagagatcc tccaagaaaa atttgaccgg atgcgtgcga aaggtgtgaa gccgagagcg 1642681 attcgcgctt tgattatcgg cattccaaac gtcggaaaat caacgctcat caaccggctt 1642741 gcaaagaaaa acatagcaaa aacgggagac agacctggta ttacgacttc tcaacagtgg 1642801 gtcaaagttg ggaaagaatt agagctatta gatacaccgg gaattttgtg gcctaaattt 1642861 gaggatgagc ttgtcggttt gagactggca gtcaccgggg ctattaaaga ctcgattatc 1642921 aatttgcagg acgtggccgt gtttggtctt cgttttctcg aagaacatta cccagaacgg 1642981 cttaaagagc gttatggcct tgatgagatc ccagaggaca ttgccgagct gtttgatgca 1643041 ataggtgaaa agcggggctg tctcatgagc ggtgggctca tcaactacga taagacgact 1643101 gaagtcatca ttcgcgatat tcgcactgaa aagttcggca ggctgtcatt tgaacagccg 1643161 acgatgtaaa ggcgcgcaga aatgcgggtc tttatttttt cttggctgaa ccgatacata 1643221 cagtaaggga gaagagaaag tgaatacatt aaccgtaaag gacattaaag accgtttgca 1643281 ggaagtgaag gatgcacaag acccatttat tgcccaatgc gaaaacgacc cgagaaaaag 1643341 cgttcaaacg cttgtagagc aatggcttaa aaagcaagcg aaagaaaaag cgctgaaaga 1643401 acaatgggtg aatatgactt cctatgaaag gctggcaaga aacaaaggat ttcgcttgat 1643461 tgcaggtgtt gacgaggtcg gccgggggcc attggcagga ccagttgtcg ccagcgcagt 1643521 catccttcca gaggaatgtg aaatacttgg gctgacagac tccaaaaagc tttcagagaa 1643581 aaaacgcgag gaatattacg agcttattat gaaggaagca ctggcggtcg ggataggaat 1643641 tgtagaagct actgtgattg atgagatcaa tatatatgaa gcttcaaaaa tggcaatggt 1643701 gaaagcgata caggatttgt cggatacacc tgattatttg cttgttgacg caatgacact 1643761 tccgctcgac acggctcagg cgtcaattat aaaaggcgat gccaaaagcg tgtctattgc 1643821 ggcaggtgcg tgtatcgcaa aagtgacgag ggaccgaatg atgagcgctt atgccgaaac 1643881 gtatcccatg tacggctttg aaaaaaataa aggctatggg acaaaagaac atttggaagc 1643941 tctcgctgca tacggcccaa ctgaattgca ccgcaaaact ttcgctcctg ttcaatcttt 1644001 cagataaatc accatggaca aggaggcacc tttttaaaat gaacatacga aatgatgtgc 1644061 aaaaggcgct gcagcacctt ttcgggcgta cagccgtccc gcaggaaaca tcaaaagtaa 1644121 acgaagcgct aaacggggag aagcgtctcc tcttaggaaa agtgcttcgt ttactaggag 1644181 atcagcatgc cctgatccaa gtcggcaatc aaactgttca gggaaaactt gaaactcagc 1644241 ttcgtcctca ggcatactat tggttttcct acgaaaaaaa aacggcagag caaacaggcc 1644301 gtcttcaggt cgttcaaagc tttgatcaaa atcctaaaac cattcaggat gcagctggca 1644361 aacttttaaa tgctatttca gtgaagacgt caaacgcagc tctcatgatg acaggagcga 1644421 tgctgaaaag caaaacaccc gtaacagaaa atgatatcaa aacagctgtc cgctggatgg 1644481 acacgctgcc ttcgcaagac acaaaaaaag cagttgaaac ggttctcttc gctttaaagc 1644541 gtgatcttcc cattcactcc gagattttga atggtgttca cgctgtgaaa tcgcctgttc 1644601 cgttgcatca gcacgtatcc cagctgctac aggcaatcga ccaaaaccct cagcagagcc 1644661 aaatgatgtc aaagctaaag gaagcagtca cggtgctttt aaatagtgaa atcgatgtcc 1644721 atgcagaacg gctgattgat aagcttattt ctttaaccga caatacgaaa gcaccttctc 1644781 cgacgaatac agctggaagc agggagctta gcacaccagc tggctccccc ggaaaagcca 1644841 gcctgccgat tgcaaatcac acagcagaac agggaagcat acaagaagag cctgttaaaa 1644901 cagcagcaga cattccaatt aaagaagccc gccagctgct ggtgaagctg acggaatctg 1644961 ctgaaaaaaa cagtctccaa attgtgaaag aagcagcaaa ttggattaaa gcggctgctt 1645021 catcgggtga tagtaagtca cttgcagctt cagctgtttt acaggcggca caagtcacag 1645081 atcaggaagc cgaagtcttt ttaaaggctg ttcagcagac agcaccccat ttggcggata 1645141 aggcagatgt tctttctttc ttatccaaag tgaaaacggc aatcggcgca agggacgagg 1645201 ttgcgttcat taaagcgttt gaacaaggaa gcgcagtcac atctggcgaa atgcaatcca 1645261 tcaagctggc tctttctgcc ttaagagcat cgcatgaggt agccgaacca gtcaaacaag 1645321 aagccgatca gctttttcat aaattaaatg gccagctttt catgcagcag gaccatccat 1645381 catacagcca aattgtaatg tcatttccga tgttttcgaa gtcaggggtt caggacatga 1645441 ctgttctgtt taaaggaaag aaagaagcgg atggaaagct tgatccttcc cattgccgcc 1645501 ttttgttttt gctgcagctt gatacactaa aagaaaccgt cgttgattgc ttggtacagc 1645561 aaaaagtcat gaccattaca atagagactg atttcgagct gcaggctgcg atcgatccga 1645621 tggtgcccgc gcttaaacag gggctaaagg aaatggggta cagcctttca ggggtaaacg 1645681 ctaaaaaaag ggttcacacc gaagaaaagg cttcaatcga tcaatatata acaagtatca 1645741 gtgatcagga agtggatgtg aaaatatgaa agagcagaca ccgatcagaa aagctgttgc 1645801 tctccattat gacgaacaaa aagacaaggc gccgagagtg attgccacag ggaagggcca 1645861 tgtagctgac aacattataa aagaagcgaa aaaagcaggg gtcccgattc aagaagatcg 1645921 gacccttgtc gaattaatgc gccatttgac ggtagatgat caaattcctg aagctcttta 1645981 tgaaacggta gccgagattt tttcattcat ttacaaattg gacgaaagcg taaaaaacaa 1646041 aaaatagcta aaatattccc catccttctt tgaaatttat gtttttaata aagtaaaagt 1646101 ttgaatgttt agaaggatta aaagattttg catcgaactg tagacaattc ttccagtatt 1646161 attatagaat gaaagcgcag tctattttag ttttgttaca taagttagga ggatgggaaa 1646221 tgaatatcca tgagtaccag ggaaaagaag tcctcagaaa atatggggta tctgttcctg 1646281 aaggtaaagt ggcttttaca gcagaagaag cagttgagag tgcaaagagc ttatccagct 1646341 cggtttatgt cgtaaaggct caaattcatg ctggcggtcg aggcaaagct ggtggggtaa 1646401 aaatagcaaa atcattagac gaagtaaaag cgtatgccga agaactatta gggaagaccc 1646461 tagttacaca tcagacgggt ccggacggcc aagtaataaa acgcttactt attgaagaag 1646521 gctgcgatat taaaaaagaa tattacatcg gtctagtgct tgaccgcgcc acttcaagaa 1646581 tcgttttaat ggcttctgaa gaaggcggaa cggaaattga agaggttgcg gagaaaacac 1646641 cagaaaaaat caaaaaagct gtcattgatc cagctgttgg ccttcaaggc tatcaagcca 1646701 gagaaattgc attcgctatt aatattccaa aagagctcgt gggaaaagct gctaaattta 1646761 tgcttggact atataaagcg tttgttgaga aagactgctc aatcgccgaa atcaatccgc 1646821 ttgttgtgac tggcgacgga aatgtgatgg cgcttgatgc aaaattgaat tttgacagca 1646881 atgcgttgta ccgacaaaag gacattatgg aatacagaga tttggatgaa gaagatccga 1646941 aagaaattga agcgtccaaa tatgatctaa gctacatttc ccttgatgga aatatcggct 1647001 gtatggtaaa cggcgcggga cttgcaatgt ctacgatgga tattatcaag cattatggag 1647061 gagaaccggc caacttcctt gatgtgggcg gcggtgcaac cgcggaaaaa gtcacggaag 1647121 catttaaaat cattctttct gatcaaaacg ttaaagggat ttttgtcaac attttcggcg 1647181 gcattatgaa atgtgatgtc atcgcagaag gggttgttga agcgactaga caagttggtt 1647241 tgacattgcc gcttgtcgtc cgtcttgaag gcacaaacgt ggatctaggg aagaaaatcc 1647301 ttagtgaatc aggattaaac attacatctg cggaatcaat ggctgacggc gcgcagaaaa 1647361 tcgtatcctt agtttaagaa agaatgaaag gcaggggacc aaataatgag tgttttcatt 1647421 aataaagata caagagttat tgtgcaaggg attacaggtt ctaccgcttt atttcatacg 1647481 aagcagatgc ttgaatacgg cacaaatatc gttggcggtg taacacctgg aaaaggcgga 1647541 acagaagcgg aaggtgttcc tgtatttaat acagtggctg aagcagttca aacaaccggc 1647601 gctaacgcgt ctgttatata tgtgcccgca ccgtttgcag ctgatgcgat tatggaagcg 1647661 gtagatgcgg agcttgatct cgtgatttgt atcacagaac atatcccggt tttggatatg 1647721 gtgaaggtca aacgcttcat ggaaggcaag aaaacgagac tgatagggcc gaactgtcct 1647781 ggtgtcatta cgcctgaaga atgtaaaatc ggcattatgc ccggatacat ccataaaaag 1647841 ggtcatgtag gcgttgtatc acgttcagga acattaacat acgaagcggt gcaccagctc 1647901 tcagaagcgg gtgtagggca atctacagct gttggaatcg gcggcgaccc tgtaaatgga 1647961 acaaacttta ttgacgtttt aaaagcgttt aacgaagatc ctgacacaca cgcagtcatc 1648021 atgattggcg aaatcggcgg tacggccgaa gaggaagcgg cagagtgggt aaaagccaac 1648081 atgacaaaac cggtagtcgg ttttattggc ggtaaaacag cacctcctgg gaagcgcatg 1648141 gggcatgcag gcgccattat ttccggcggg aaagggacag ctgatgaaaa aatcaaaacc 1648201 cttaatgcat gcggaatcga agttgcagag acaccttctg tcatgggtga aaccttaatc 1648261 aaggtgctga aagagaagaa cttgttcgaa acttgtaaaa cgcattaata aaaaagggac 1648321 agccgtcaag gctgttcctg ctttttctaa caaaaggagg tcaatctatt ggatcaggcc 1648381 gctgtctgcc taacgatttg cagaatcaat caattattat ccccatccct tctattaaaa 1648441 tggtggaaag ccgatccgtc tatgtcgctg acatcacccg tgttacaaac ggttactcgt 1648501 gatcaaataa aagcagctgc attaaaaaac gaaatagaac aattttatcc aaagctcccg 1648561 cgtgtacttg ctgcttatcg tgagcaaggc attaacacca tccctatttc ttcaaagcaa 1648621 tatcctttct ggcttaaaag catttatgat ccccctgccg tactgtttgc aaaaggtgat 1648681 atgactcttc tttcgaaagg gagaaaaatt ggaattgtag gcacaagaaa tccaacagct 1648741 tatgggaaac aagttgtcaa tcatcttaca aaagagatct gtcgtaaagg ttgggtgatt 1648801 gtcagcggac tggcgtctgg gatagacgga atgtcccatg ctgcaagtat taaggcgaag 1648861 gggcggacaa ttggcgtcat tgcaggcgga tttcaacaca tttatccccg agaaaacctt 1648921 cagttagcag atcacatggc taaacaccat atcctgctgt cagagcaccc acctgaaact 1648981 aaaccccaaa aatggcattt ccctatgaga aaccgtatta tcagcggact aagtgaaggc 1649041 gttattgtcg ttcagggcaa agaaaaaagc ggttcgctga ttactgccta tcaagcattg 1649101 gaacaaggga gagaggtatt tgccgtaccc ggttcattgt ttgaccctta cgccggaggt 1649161 cctataaaac tgatccagca gggggctaaa gccatatggt cagcagagga tattttcgag 1649221 gaacttcctg agagaaacgt tcaatatacg gaaccctttt gaattatcgt ttgacaaacg 1649281 gtattgtaat atttaataat agtgaggatt taaagttgca tattgttttc tatttaatta 1649341 atgacgttca tgataaagaa tgaaatgttg aaagccaaat aaagacagct gcaaaaataa 1649401 aattgaaata tcttgaaaag agagagaaca cctcttgagg gggatgaaaa tgtctgatta 1649461 tctagtcatc gtggaatcgc ccgctaaggc gaaaacgatt gaacgttact taggtaaaaa 1649521 atataaagta aaagcatcaa tgggacatgt ccgggatctt ccaaaaagtc aaatgggagt 1649581 tgacatagaa cagaattttg aaccgaaata tattaccatt cgaggtaaag gcccggtatt 1649641 aaaagagctg aaaacggctg cgaaaaaagc caaaaaagtg tatctcgcag ctgaccccga 1649701 cagagaaggg gaagcgattg catggcattt ggcacacagt cttgatttag atctcaactc 1649761 agactgccgt gtggtgttta acgaaattac aaaagacgct attaaggaat cgtttaagca 1649821 tccccgcatg atcaatatgg atttagtgga tgcacagcaa gcgagacgta ttttagacag 1649881 gcttgtcgga tataaaatca gtccaatctt atggaaaaaa gtcaaaaaag ggcttagcgc 1649941 aggacgcgtg caatccgttg ccctccgttt gattattgac cgtgaaaaag agattaacga 1650001 ctttaagcct gaggaatatt ggacaattga cggtacgttc ttaaaaggtc aagaaacctt 1650061 tgaagcgagc tttttcggga aaaacggcaa aaaacttcct ttaaatagtg aagctgatgt 1650121 aaaagagatt ctttctcagc tcaaagggaa tcaatataca gttgaaaaag taaccaaaaa 1650181 ggaacgcaaa cgtaatcctg ctttgccttt taccacttct accctgcagc aggaagcggc 1650241 tcgcaagctc aatttcagag cgaagaaaac gatgatgatt gcacagcaat tatatgaagg 1650301 aattgattta ggaagagaag gaacggttgg tctgatcacg tatatgagaa cggattcaac 1650361 ccgtatttca aatacggctg ttgatgaagc agctgcattt attgatcaga catatggaaa 1650421 agagttccta ggcggaaaac ggaagcctgc gaaaaagaat gaaaatgccc aggatgccca 1650481 cgaagcaatt cggccgacat cagttcttag aaaaccaagt gaattaaaag cagtcctcgg 1650541 cagagaccaa atgagactgt ataaattaat ttgggagcgt tttgttgcca gccaaatggc 1650601 accggctgtt ctcgatacaa tgagtgtcga cctgacaaac aacggtttga catttcgtgc 1650661 aaatggaagt aaagtcaagt tttccgggtt tatgaaggtg tatgttgaag gaaaagacga 1650721 tcaaatggaa gaaaaagacc ggatgctgcc tgacttacaa gaaggcgaca cggtattatc 1650781 aaaagatata gaacctgagc agcattttac ccagccgcct ccgcgatata ctgaggcccg 1650841 gcttgttaaa acccttgaag aacgcggtat cggccgtcca tccacatatg ctccgacact 1650901 tgatactatt cagcggcgcg gctacgtggc attggataat aaacgtttcg ttccgactga 1650961 attaggtcag atcgttcttg acttgatcat ggagtttttc cctgagatca ttaacgttga 1651021 gtttacagct aaaatggaga gagatcttga tcatgttgaa gaaggaaata ccgaatgggt 1651081 caagattatc gataatttct acaccgattt tgaaaaacgc gtcaaaaaag ccgaatcgga 1651141 aatgaaggaa gttgagattg aaccagagta tgctggagag gattgtgaat tgtgcagttc 1651201 tccaatggta tataaaatgg gacggtacgg taaattctta gcttgctcca acttccctga 1651261 ctgccggaac acgaaaccga ttgtgaaaca aatcggtgtg aagtgcccga gctgcggaga 1651321 aggaaacatt gttgagcgaa aatcgaaaaa gaaacgggtg ttttacggct gtgaccgtta 1651381 tccggactgt gaattcgtat catgggacaa accaattgaa cgaaaatgcc cgaaatgcgg 1651441 aaaaatgctc gtcgagaaaa aactcaaaaa aggtatacaa gtccaatgcg tggaatgcga 1651501 ttataaggaa gaaccacaga agtagcggtg agcagggtct tgctcacctt ctttgtgtgt 1651561 taaaagaagg ccttgaataa taaactagga gatgtgaaag atgaaccaac aaacagtgaa 1651621 tgtaatcgga gccggactcg caggaagtga agcagcatgg cagcttgcca aacgtgggat 1651681 tcaagtcaaa ttgtatgaaa tgcggccagt taaacaaacg cctgcgcatc atacagataa 1651741 atttgctgag cttgtctgca gcaactctct tcgctctaat acacttgcta acgctgtcgg 1651801 tgtattaaag gaagaaatgc gtgcgcttga ttcagccatt atcgctgcgg ctgacgaatg 1651861 ttcggtgcct gccgggggcg ctcttgcagt agaccgtcat gaatttgccg caagtgtgac 1651921 aaatcgggtg aaaaatcatc caaacgtaac cgttattaat gaagaagtga ctgaaattcc 1651981 tgaaggccct actatcatcg caacgggtcc gttaacatct gaatcgctgt ctgcccagct 1652041 gaaggagctg actggagagg actatttata tttttatgac gcagcggcgc caattgtaga 1652101 aaaagacagc cttgatatgg ataaagtgta cctgaaatcc cgttatgata aaggtgaagc 1652161 agcatatttg aactgcccga tgacagaaga agagtttgac cgttttcatg aagcattaac 1652221 atcagcagaa acagtgccgt taaaagaatt tgaaaaagag attttctttg aaggctgcat 1652281 gccgattgaa gtcatggcaa aacggggtaa gaaaacaatg cttttcggtc cgatgaaacc 1652341 agttggtcta gagcatcctg ttacaggaaa acgcccttat gccgtcgttc agctcagaca 1652401 ggatgatgct gcgggaacac tttataatat tgtaggattc cagacacatt taaaatgggg 1652461 agaccaaaag gaagttctca agttgattcc aggacttgaa aatgtagaaa tcgtcagata 1652521 tggcgtgatg catagaaaca catttattaa ctctccaagc ctgttaaagc cgacttatca 1652581 atttaaaaac cgcagtgatc tgttctttgc aggccaaatg acgggagtag aaggatatgt 1652641 ggaatcagct gcctcaggac ttgtagcagg cattaatgcg gcgaagcttg tattgggaga 1652701 agagcttgtg atcttccctc aggaaacagc aattggcagt atggcacatt atattacaac 1652761 aacaaaccag aagaacttcc agccgatgaa tgcaaacttt gggcttttga aagaattgcc 1652821 agttaaaatt aaaaataaaa aagaacgaaa tgaacaatac gcgaaccgtg cgattgaaac 1652881 aattcaaaca atttcgaaaa caatataggt attgattgca acctgagcgc gatttgtgat 1652941 accatttaaa agcccttcct ggggaggtat taggcatgga gaatgttaag aatttcgtaa 1653001 agttattcgt tgaatattta caaattgaaa aaaattattc acaatatact attgtgaatt 1653061 atgtggattc aattgaagaa ttcgagactt tcctgcgcgt tcaaggtata aatggatttg 1653121 aagaagctgc atatcaagat actaggattt ttttgacaga agcctatgaa aaaggtttat 1653181 cgagaagaac aataagcaaa aagatatctg cattaagaag cttttataag tttctgatgc 1653241 gggaaaagct tattgaagaa aatccgtttc agcttgttca tctgccaaaa caggagaaac 1653301 ggataccgaa gtttctatat caaaaagagc ttgaggagct gtttgaagtt tcagatataa 1653361 gccagccggc cggaatgagg gatcaagcgc tgttagagct gctctatgcc actggaatga 1653421 gggtcagtga atgctgttcc ataactatta acgacgttga tttatttatg gacactgtgc 1653481 ttgttcacgg taaaggcaag aagcagcgct atatcccctt tgggtcttat gcccgcgaag 1653541 cgttgaaggt atacatgaat agcggaagac agtgcttgct gatgaaggca aaagaacctc 1653601 atgatctatt attcgtaaat caaagaggcg gaccgcttac agcccgtggc atcagacata 1653661 ttttaagcgg gcttgttcaa aaagcgtcaa gcactttaca tatccatccg catatgcttc 1653721 gacatacgtt cgccacgcat ctgttaaatg aaggagcgga tttgagaagc gttcaagaac 1653781 tgctcgggca ttccaatctg tcttctacac agatatacac gcacgtttcg aaggaaatgt 1653841 tgagaaacac atatatgtct caccatccaa gagcatttaa gaaaaattaa aggaggccct 1653901 ttatgtcatc ttttcatgcg accacaatat ttgccgtaca gcataaagga cgaagcgcta 1653961 tgtccggaga cggccaagta acatttggtc aggctgttgt catgaaacac acggcacgga 1654021 aagtgagaaa actgtttaac ggcaaagttc ttgctggttt tgcgggatct gttgcagacg 1654081 ctttcacttt attcgaaaag tttgaagcta agcttgaaga atataacggc aacttaaaac 1654141 gggcggctgt tgagcttgca aaggaatggc gcagtgataa agtgctaaga aagctcgaag 1654201 ccatgctgat tgttatgaat caggatactt tgcttctcgt atcgggaaca ggcgaggtga 1654261 tcgaaccaga tgacggcatt ctcgcgattg gatcaggagg caattacgct ttggcagcgg 1654321 gaagagcact gaaaaagcat gccggggaaa gcatgtctgc aagtgagatt gccagagccg 1654381 cgttagaaac agcaggcgaa atttgtgttt acacgaacga tcaaatcata ctggaagagc 1654441 ttgaatagaa aggacttgag gcgcatggaa aaaaaaccgt taactcctag acagattgta 1654501 gatcggttag accaatatat tgtcggtcag caaaatgcga aaaaagctgt cgccgtggca 1654561 ttaagaaacc gctatagaag aagtcttctg gatgaaaagc tgaaggacga ggtcgttccg 1654621 aaaaacattt taatgatggg tcctaccggc gtcgggaaaa ctgaaattgc cagacgaatc 1654681 gctaagcttt caggtgcgcc atttatcaaa attgaagcta ctaaatttac cgaagtcggc 1654741 tatgtaggca gagatgttga atcaatggtc agagatcttg tggagacttc tgttcggctt 1654801 ataaaagaag agaaaatgaa tgaagtaaag gaacaggcag aagaaaatgc aaacaaacgc 1654861 attgttcgtc tgttagttcc tgggaagaaa aaacaatctg gtgttaaaaa tccgtttgaa 1654921 atgttttttg gaggcagcca gccgaatggt gaagatgagg cggagagcca ggaagaagca 1654981 aacatcgaag aaaaaagaaa acgaatggcg catcagctgg ctttaggaga gctcgaagac 1655041 tactatgtaa cagtagaagt cgaagaacag cagccttcta tgtttgacat gctgcagggc 1655101 tcgggtatgg agcagatggg tatgaacatg caggatgcgc tgagcggatt aatgccaaag 1655161 aaaaagaagc ggcgcaaaat gacagtcaga gaagccagaa aagtcctgac gaatgaagaa 1655221 gcaagcaaac tcatcgatat ggatgaagtc ggccaggaag ctgttcagag agcagaagag 1655281 agcgggatta tctttatcga tgagattgat aaaatcgcaa agaacggcgg tgcatcttct 1655341 tctgccgatg tttcaagaga aggtgttcag cgggatatcc ttccgattgt tgaaggttct 1655401 accgttgtca caaaatatgg ttctgtaaaa acagaccatg tattatttat tgcagcagga 1655461 gcgtttcata tggccaaacc gtctgatttg attcctgagc tgcaggggcg tttcccgatt 1655521 cgtgtagaac tgaacaaact cacggtagac gacttcgtga gaattttggt tgagccggat 1655581 aatgcgctgc tgaaacaata tcaggcatta ttgcagacag aaggtatatc tcttgaattt 1655641 tctgacgaag ctattcataa gattgctgaa gttgcttatc atgtgaacca ggacacagat 1655701 aatatcggtg cgagacgcct tcatacaata cttgaacgcc tattagaaga tttgtcgttt 1655761 gaagctccag atgtaacgat ggagaaaata acgattacac cacagtatgt cgaagaaaag 1655821 ctcggaacga tagccaaaaa caaagattta agtcaattta tattgtgaaa aatttaatat 1655881 gaggaatgtt taggaggatt atttatcatg gctttattac aaaaaacaag aattattaac 1655941 tccatgctgc aagctgcggc agggaaaccg gtaaacttca aggaaatggc ggagacgctg 1656001 cgggatgtaa ttgattccaa tattttcgtt gtaagccgca gagggaaact ccttgggtat 1656061 tcaattaacc agcaaattga aaatgatcgt atgaaaaaaa tgcttgagga tcgtcaattc 1656121 cctgaagaat atacgaaaaa tctgtttaat gtccctgaaa catcttctaa cttggatatt 1656181 aatagtgaat atactgcttt ccctgttgag aacagagacc tgtttcaagc tggtttaaca 1656241 acaattgtgc cgatcatcgg aggcggggaa agattaggaa cacttattct ttcgcgttta 1656301 caagatcaat tcaatgacga tgacttaatt ctagctgaat acggcgcaac agttgtcgga 1656361 atggaaatcc taagagaaaa agcagaagaa attgaagagg aagcaagaag caaagctgtc 1656421 gtacaaatgg ctatcagctc gctttcttac agtgagcttg aagcaattga gcacattttt 1656481 gaggagcttg acggaaatga aggtcttctt gttgcaagta aaattgctga ccgtgtcggc 1656541 attacccgtt ctgttattgt gaacgcactc agaaagctgg agagcgccgg tgttatcgag 1656601 tctagatcat taggaatgaa aggtacttat atcaaggtac taaacaacaa attcctaatt 1656661 gaattagaaa atctaaaatc tcattaatca caaaaagaac cctttttgag ggttcttttt 1656721 ttatttcaaa taaaggaaat caataagctt tatttcctgg gttgaaagtc tttctatgta 1656781 ataattttaa taaattttgc atttttcttc aaaaagtttc aaaaatgccg aaaagaaagg 1656841 agaaaaaaca gaaattctgc tattttcagg cttatatcaa ggcgagaaat gtagttctaa 1656901 caatctagga ctttatacct agttgcaaaa tagataattg tgaggacatt tttttacacg 1656961 aacttcatag actttatgcc tgttatttct tacaataagc atatagtttt acaattctcg 1657021 acaaggatat tgagggtgaa aaaaactgaa atggaggtaa gtggatttga gcttattttc 1657081 tggaacgata caaaatcttg aaaatgcctt gagcagagcg gatattaagc aaaaagtcat 1657141 aactaataat atcgccaata tagatacacc gaactataag gcaaaaaaag tctctttcca 1657201 aaatttatta gatcaagaat cctcgcgtct tgaagcgata aaaacagact atcgtcatgt 1657261 tgatttttct gatactgatt cgaattattc aattgttgcg agcggagata catcgtatca 1657321 gcaaaacgga aacaatgttg atgttgacaa agagatgaca gaattggcgc aaaatcaaat 1657381 caactatcaa gctttggttg aaagaatgaa cggtaaattt aattcgctga agaccgtatt 1657441 aacaggagga aaatgatgac agcttttcat agcttaaatg tttcagcatc ggctttaaca 1657501 gctcagcgag tcagaatgga cgttgtatca tctaacttag caaatatgga tacgacaaga 1657561 gctaagcagg tgaatggaga gtgggtgcct tacagaagaa aaatggtttc ccttcagtca 1657621 aaaggtgaat cgttctcttc cattctcaat tctcaaatga gcggaagcgg gaatgctgga 1657681 aacggtgtga aggtttcaaa aattacggag gatgattcgg attttaatct tgtctatgat 1657741 ccgacagacc ctgatgcaaa cgctgaagga tatgtacaaa agcctaatgt tgatccatta 1657801 aaggaaatgg ttgatcttgt cagcagcact agatcatacg aggcgaatgt cacggcgatg 1657861 aatgccacaa agggaatgct gatgaaggcg ttagaaatcg gaaagtaggt gaatgaatgt 1657921 gattaatgca atttctcctt ttcaggttca aaatactcaa aacactcaaa atgcaacaaa 1657981 tcaagtaaac aatagccaaa aaacagattc ttcaaatcaa acaagctttt cggagctttt 1658041 aaaaaactct attagttcgt taaatgagtc ccaagtagct tctgacaaca tgactaatgc 1658101 cttggctgca ggaaaagatg taaatcttga tgaggtcatg atcgctgctc aaaaagctag 1658161 catctctcta actgcagcaa cagagttccg caataaagct gtggaagctt atcaggagat 1658221 tatgagaatg caaatgtagg gggtctgacg atttagagaa agagtggaat gaccgggggt 1658281 taacatgaat cgtactctaa tgcaaatgaa aaacaaaacg agtgagtttt ggaaaaatag 1658341 atctaaatta caaaagattt taatggttag tgctttagcg gcaattatta ttattggaat 1658401 tattattagt gtttttgctt caaattctaa aatggcgccg ctgtacaaag atttgtctgc 1658461 cgaagaagca ggacaaatca aagaagaatt ggatgcaaaa aaagtgccaa acgaactttc 1658521 gaatggcggt acagtgatta gtgttccgga ggatcaggtt gattctttga aagtgcagat 1658581 ggctgcagaa ggacttccta aaacgggatc aattgattat tcgttttttg gacagaatgc 1658641 cggctttggt ttgacagaca atgagtttga tatggtgaaa gtgaaagcta cacagacaga 1658701 actgtcaaac ttgatcaatg aaatggacgg tattaaaaat tcaaaagtaa tgattaatct 1658761 cccgaaagac gctgtgtttg tcggtgaaga gcaatctgca gcatctgcat caatcgtttt 1658821 gcagattcaa ccgggttata cacttgatca aagccaaatc aacggattat atcatctggt 1658881 atctaaaagc gtgccaaacc taaaagaaga taacatcgtc atcatggacc aaaattctac 1658941 atactacgac aaatcagaca gcgatgcagg gtcctacgcg gatagttatt cttctcagca 1659001 aggaattaag tctcaagttg aaaaagacat tcaaaaacat gtacagtcac tgctgggtac 1659061 gatgatgggc caagataaag tcgttgtctc cgttacagca gacattgatt tcacaaaaga 1659121 aaatcggaca gaagacattg tcgaacctgt ggataaagaa aacatggaag gcattgcagt 1659181 cagcgctgaa aaggtatctg aaacatatca gggcgacggt gcagccaacg gcggaactgc 1659241 cggaaccggc gaggaagatg ttacaaatta taaggctgac ggtgaaaata ccgaaagcgg 1659301 gaactacgaa aaaaacagca acaaaatcaa ttacgaggtt aaccgaattc ataaagaaat 1659361 cgctgaaagt ccttataagg tcagagattt agggattcaa gtaatggtag agccgcctga 1659421 tgccaaaaac actgcgtcgc tatcaactga aagacaggat gatatacaaa aaatcctttc 1659481 aactgtagtc agaacatctt tggataaaga tgaaacgcaa aatcagaatt tatctgatgc 1659541 tgatatcaat aataagattg ttgtttccgt tcagccattc gacggaaaag tcaatttgga 1659601 tacaaatacg gaagaatcct caggtatccc gctgtgggca tatattgtag gcggtgtttt 1659661 aatcgcagcg atcattgttc tgatcattat gcttatcaga aagaaacggg cgcaagagga 1659721 tgaatttgag gaatatgagt atgaggttcc tcaagaacca atcaatttgc ctgatatcaa 1659781 cgaagaggaa aatgaaacag cggaatcagt cagacgaaaa cagcttgaaa agatggcgaa 1659841 agacaagccg gaagattttg caaaactgct gagaagctgg ctggccgagg attaggagga 1659901 attagaaatg gcgagacgtg atcaagataa gcttacagga aaacaaaaag cagccattct 1659961 catgatttcc ttggggttag atgtgtcagc ttctgtctat aagcacttaa ccgatgaaga 1660021 aattgaaagg cttactctgg aaatatcagg tgttcgaagc gtcgatcatc aaaaaaagga 1660081 tgaaatcata gaagaatttc ataatatagc cattgcgcaa gattatattt ctcaaggcgg 1660141 tttaagctat gcaagacaag ttctggaaaa ggcgcttgga gaggataagg cggagaacat 1660201 tctaaacagg ctgacttctt ctttgcaggt taaaccattt gattttgcca gaaaagcgga 1660261 gccagaacaa attttgaatt ttatccagca agagcatccg cagacgatgg cgttaatctt 1660321 gtcttattta gatccagtgc aggccgggca aattttatcc gagctgaacc ctgaagtgca 1660381 ggctgaggtt gcgagaagaa tcgcggtcat ggatagaacg tctccagaaa taattaacga 1660441 ggtagaacgg attctggaac aaaaattatc ttctgcattt actcaggatt atacacaaac 1660501 aggcggaatt gaagctgttg tggaagtgtt aaacggggta gacagaggga cagagaagac 1660561 gatcttggat tcattggaaa ttcaggatcc cgatcttgct gaagagatta aaaagcggat 1660621 gtttgtcttc gaagatattg tcacacttga taaccgtgca attcagagag tcattcgcga 1660681 tgttgagaac gacgatttgc tcctttcatt aaaggttgca agcgaggaag tcaaagaaat 1660741 tgtgttcaac aatatgtcac agcgtatggt tgaaaccttc aaagaagaaa tggagtttat 1660801 gggccctgta cgtttgaaag atgtagaaga agctcaatca agaattgtaa gcatcgtcag 1660861 aaagcttgaa gaagccggtg aaattgtaat agcaagaggc ggaggggatg atattattgt 1660921 ctaatatcat taaacaagaa tcatctattt ctccacaaaa ggaaaaaaga aaactttcta 1660981 tacaagaggt gcgtattgat cattctcacc ttttgcaggc tgaagagaac ccggaggcgc 1661041 ttatggcccg agtgaaagag gaagctgacc ggatttctga gcaggcaaac agtcatatag 1661101 aaaatattcg ccgtcaaatt gaacaggaga aaaacgattg ggcggctgaa aaacagaagc 1661161 ttattgaaga agcaaaagcc gagggctttg aacaaggagt agcgctgggc aaagctgagg 1661221 caatgaaaca gtatgcagaa ctgatcggcc aagcaaacag tataactgaa atgtccagaa 1661281 aagctgttga ggacaagctt gaagacgcta atgaagaaat cgttgagctt gccgttgccc 1661341 tagcaaaaaa agtttggcag caaaagtctg atgataaaga ggctttcctc ctgcttgtac 1661401 aacaggttat aaacgaagtg aaggaatatg acgatatatc aatttatgtt gatccatatt 1661461 actatgagac aatctttcag caaaaagatg aaatccagca gcttctttat aaagaatgtc 1661521 ggcttggcat atatgctgat gaaaaagctc aaaaaggaac ctgttatatt gaaactcctt 1661581 ttggcagggt agatgcgagt gttgacacac aattgatgca attgaaagat aaacttctga 1661641 cagcgctgga agcaggtgca gctgaatgaa gacacagagt ctgatagatt gtatagaaat 1661701 gacagactcg tataaacggt acggaaaagt caagcgggta atcggcttga tgattgaatc 1661761 aaaagggcca gcaagctcaa ttggtgacct gtgcctgatt tatgcaaaag gacagtctgg 1661821 gaaagtcatt aaagctgagg tagtcggctt ccaggaagaa aatattttgc ttatgcctta 1661881 tttagaggct gcgagcattg cacctggcag cattgtagaa gctactgggg aatcacttcg 1661941 ggttaaagtt gggaccggac tgatcggaca agtcatcgat gcttttggag aaccgcttga 1662001 cggaaagctt ctgccgaaag ggctttcgcc tgtatcaacg gagcaatcac cgcctaaccc 1662061 gatgaaacgg ccgcctatcc gtgaaaagat gggtgttgga gtcagatcaa ttgacagctt 1662121 gctgacagtc ggtaaaggcc agcggattgg aatttttgca ggaagcggtg tcggaaaaag 1662181 caccttaatg gggatgatcg ccaagcagac agaggctgac ttaaacgtca ttgcacttgt 1662241 cggagaacgc ggacgagagg ttcgggagtt tattgaaaaa gatctgggga aagaggggct 1662301 gaaacgatcg attgtagtcg ttgccacctc agaccagcca gcattaatga gattgaaagc 1662361 ggcatataca gcgactgcaa ttgccgagta tttccgagat aaaggccaaa atgtcatgtt 1662421 tatgatggat tctgttacaa gggtggcaat ggcgcagcga gagattggac tggctgcagg 1662481 agagcctccg acgacaaaag gctatacacc ttcagtgttc gctattttac ctcgtttact 1662541 agaacgaaca ggtgcaaacg agcatggaac cattacggca ttttatacag tgttggtaga 1662601 tggggatgac atgaatgagc cgattgccga taccgtacgc ggaattttag acgggcatat 1662661 tgtgttggac agggcgcttg ccaataaagg ccagtttcct gcagttaacg tactaaaaag 1662721 catcagcagg gtgatgtcaa acatttcaac aaaacagcat ctggatgcgg caaataaatt 1662781 ccgtgaactt ttatcgacat atcaaaattc ggaagatctc attaatatcg gagcttacaa 1662841 aagaggatca tccagagaaa ttgatgaagc gatacaattt tatccgcagc ttattcaatt 1662901 tttaaagcag ggaacagacg aaccggcttt attggaagaa agcattgctg cattaactag 1662961 tttgacagga aatgaggaat aaacgtggct tatcaattta gattccaaaa gctgctggaa 1663021 ctaaaagaaa atgaaaaaga ccaatcctta tccgaatatc agcaatcagt ttctgaattt 1663081 gaaaacgttg ctgaaaaatt atatgagaat atgagcaaaa aggaattgct ggaacaaaat 1663141 aaggaaaaga aattaaaaag cggcatgagt gtacaagaaa tgaggcacta ccaacaattt 1663201 gtctcaaatc ttgataatac gatctatcac tatcaaaagc ttgtcattat gaaaagaaat 1663261 caaatgaatc aaaaacaaga aattttgaca gagaaaaaca ttgaagtgaa aaagtttgaa 1663321 aaaatgcgtg aaaaacagtt taaaatgttt gctcttgaag ataaagctgc agaaatgaaa 1663381 gaaatggacg atatttcgat taagcagttt atgattcaag gccattagga gcgaatgtaa 1663441 tgtccggcaa aaagaaagaa tcaggtaagt tccgttcggt tttgcttatc attatcctcc 1663501 cgctgatgtt tctattaatc gcagggggga ttgttctttg ggctgctggt atcaatgtct 1663561 taaagccgat acaggatgct gcggcaaaaa cgccggttct taaagaattg gtccctgaaa 1663621 ccgaaaataa aaaaggcgca gcatcaagta aggatagcag taatacggca gctctggaaa 1663681 agaccattaa ggatcaaaaa agtgaaatca gtatattgaa taaagattta gaaacaagta 1663741 aatcagaaat cgacaggctc aatcaaaaga tccgttcact tgaaaagacg gctgaggatc 1663801 aaaaaaagtc atcagaagat catactgaag gatcagcaga ctcgaaagct tcttctgaaa 1663861 atgacaaagt gatcagtgtg tacaaaagca tggacagcgg aaaggctgct aaaattattg 1663921 cccaattaaa ggagcaagaa gcactgaaaa tattgaatgg cctaagcaaa aagcagcttg 1663981 ctgacatatt ggcgaaaatg actcctgagc aagcagcaac ctatacagaa aaaattgctg 1664041 ccagccaaga atagggggaa tgaaaggtga agctgcttga attagccgga cctttgctgc 1664101 aaaccacaac gggttctgcc gctaaaaaca tgaaaagtag ccagggagtt tttcaaaact 1664161 ggcttatgtc tgaggctgga ttgaaggaac tttcagaaca aggaaaggga actcctaatt 1664221 ctgaagatca gcttttagca gatgcgctta aaaagatcgg tgaatggcta aatgcaagtc 1664281 ctgaagatca agacaaacaa aatgcggatc ttttgcaaac attaagcaaa ctgacaggga 1664341 agcaattgga tgcgaatgct ctgcaaatgt tgcaaaatct tttgcaagca gttgaatcaa 1664401 aaatgtcagg cgggacggat caattgctca cagaaacgga gaaaatcttt tcagaagcta 1664461 aaacggctct gagtgccaat gattctgctt ctgacattaa tggagcactg aagtctgata 1664521 aagagcaatc aaatcaggaa aatgaagtat ccgagcctgc aaaagagctt atctatatcc 1664581 agatgttcat tagccagctc gtagaaggga ataagctgac tgatctcggg aatggcaatg 1664641 aagctcatgc catttaccaa aatggagatc aattcctttc tgcattagaa aagaagggtg 1664701 tatctcaaca actaattcag gatcttaaac agcaaatatt cactaaagct gagtcaagtt 1664761 caaaacttta ctcgatgaca gcgtcagagc tgaaaagttt tcaaagctta atggatcaaa 1664821 tgtctatgct tcctcaaaaa gggaccaaag aatggagttt agctgaaagc cagctgaaag 1664881 ccttcttgtt atcgaaatca tccgaatcat cacaagactt tgggaagagt gttctcacac 1664941 cgctctcgca gagttcatcc agcaaaaatg catcggatgt ttctggaagt attcagcctg 1665001 tagatagtaa atcaggactc caaatgctgt tttcggggta tcggggcata ggaggagttc 1665061 aaacacttga tctgcagcag atgtcatctg atataccaaa tgccgaaaca aaaacggtgg 1665121 ctgatcaagt gattaatgcg tggaagcaga tgaaatatac gcctttcggc agatcgacgg 1665181 gaagtttcac tattcggctg aaccctgaac atttaggatt tgtcacaatc aagctgacaa 1665241 atgaaaatgg aatgtttcag agtaaaatca tagcatctag ccaatcagca aaagaattgc 1665301 ttgaacagca tcttcctcag ctgaagcaat cattgccgaa tatggccgtc caaattgacc 1665361 gttttactct tccggtccaa agcggggatc agccgatata cggccagctt gctgatgaac 1665421 agaaacagca gcaagagggg cagagacagc aaagacagaa aaagcaatca aatgattttg 1665481 gcgatctgct cgatgaagtg tcgatggttg aaatggagga agaagaatga cttctataag 1665541 ttcagaatat aaactgcctg aaaaaacgaa cactgtgtcg acgaacaaca gcagcttggg 1665601 gaaagacgag tttttaaaaa tattaatgac tcaagttcaa aaccaagatc cgcttaaccc 1665661 gattgacgat aaagaattta tcagccagat ggcgactttt tcaagcttgg agcaaatgat 1665721 gaatctgaat acgacaatga ctcaattcgt tgaaaaccaa gatccgttta caacgtatgt 1665781 tgattggatg ggaaaagaag tatcttggac tgatggtaaa agtgcaacag ataaaacagg 1665841 cacagtaagc tctgttaaac attttaaagg aaattattat ctcgttcttg atgatgggac 1665901 cgagatcagt cctgcgaatg tcatgtctgt gggacaatca tctaaataaa aacatctggg 1665961 ggaatatatt atgttacgtt cactttattc tggaatcagc ggtatgaaaa actttcaaac 1666021 aaagcttgac gtaatcggta acaacattgc caacgtaaat acagtaggat tcaaaaagag 1666081 ccgtgtgacc tttaaagata tggtaagcca aacgattgcc ggcggttctg ctgctggtgc 1666141 aacaatcggc ggaacaaact ctaagcaaat cggtttaggt tcatcatctg gcacaattga 1666201 tacaattcat tcaacaagcg cgacacaaag cacaggaaga acacttgatt tagcaattga 1666261 cggcgacggt tacttccgaa ttgatacagg tgacgggaca gcttatacaa gagcagggaa 1666321 cttctattta gataatactg gaacactggt tacaggtgat ggctaccatg tactaaatat 1666381 gaatggcgga acaattaaaa ttcctactga tgctcaaagc tttagcattg gttctgatgg 1666441 aaaggtgtca attgttgatg ctgaggggaa aacacaagac gggggacaaa tcgggattgt 1666501 tacttttgcc aacagtgatg gattggataa aatcggaagc aacctatacc gtgaatcttt 1666561 aaactctgga acggccagtg cagcgaacca gcctggtgac ggcggaactg gtgctcttaa 1666621 atcaggattt ctcgaaatgt ctaacgtcga tttaactgac gaatttactg aaatgatcgt 1666681 agcccagcgc ggattccaat caaactcaaa aattattaca acatctgatg aaatccttca 1666741 agaactggtt aaccttaaac gttaaggagg gaggggaggc gagtaatcgc ttctccgctg 1666801 ttttatgatt aaagtaaccc gtttgaacgg gcagcccttt acactgaatg cgctatttat 1666861 tgaacagatt gaatgttttc cggatactac aattactctg tcaaatggta agaagtttgt 1666921 agtaaaagaa gatgaagaag ctgttctgga aaagatcgca gctttctacc gaaaaataca 1666981 aatatttgca atggatcaag gaatagagga accggaatga agaaaaagtt aatgatcata 1667041 ttactaatta ttcttatcgt aattggtgct ctcggggcgg cggcttattt tgttttaggc 1667101 ggaaagtccg aaaaaagtga agcgaaaaaa agtattgatg aaatcgttgc gtcttctgtt 1667161 gatgtagaag agatcacaac aaatttaaag tctgataaca ttatccgtct tgctattaaa 1667221 cttgaaactg attctgataa atcaaaagaa gaacttgaga aacgtgattt ccaagtgaaa 1667281 gacgctgtta tatcactgct ggctgatacg aatgctgatc agattgaggg agacaaggga 1667341 aaagaaacct ttaagaagga actaaaagat aaaataaata gctacctcca agaaggaaaa 1667401 gtagaaaaag tgtatattac ctcctttaat ctgcaataaa gcataatttg acagaatacg 1667461 gaggtgagga aaatgtcagg agaagttctc tcccaaaatg aaatagatgc actgctctct 1667521 gcaatatcaa ctggtgaaat ggacgctgaa gagctgaaaa aagaagaaaa agagaagaaa 1667581 gtcaaggttt atgatttcaa acgtgcgctg cggttttcta aggatcagat ccgcagttta 1667641 acgagaattc atgacaattt tgcaagactt cttaccactc atttttctgc tcagctcaga 1667701 acctatattc acatatctgt cagttctgtt gatcaggttc cgtatgagga atttatcaga 1667761 tcgattccaa acatgacgat tctgaatcta tttgatgttc atccgatgga aggaagaatt 1667821 atgatggagg tcaaccccac gatagcttat acgatgatgg atcgagtcat gggcgggatt 1667881 ggaatcagtc ataacaaggt tgacagtttg acagaaattg aaacaaaaat catttctaat 1667941 ttatttgaaa atgcactggg taattataaa gaagcttggc agtcaattgc tgatattgaa 1668001 ccggaaatga ctgagtttga agtgaatccg caatttgttc agatggtatc tcctaatgaa 1668061 acagtcgtgg tgatctcgct caatactcaa attggtgaaa tcagcggtgt cattaatctc 1668121 tgtatcccgc atattgtact cgagccgctc ataccgaagc tttcagtcca ctattggatg 1668181 caatcagacc gaaatgagcc aaagcctgag gaaacaaagt cgcttgaaaa acgtatcatg 1668241 acagcacaaa tacctgtcgt ggccgagctc ggcacatctg aactgacgat agaagagttt 1668301 ttaagtttag aagtcggaga ctgcataact ttggacaaat cagtcacgga tcctcttact 1668361 gtattggtcg gagataagcc gaaattttta ggacaagccg gccgggtgaa tcgaaaacag 1668421 gcagtgcaaa ttttagatca cgacataaga ggtgaacaag atggagaata atagattatc 1668481 tcaagatgag attgacgcgc ttcttaacgg tactggcagc acgcttgatg agccagagat 1668541 tccggaagta gatgacttat cggaaatgga gcgtgatgcg atcggtgaaa tcggtaatat 1668601 ttcattcggc agttctgcga cagcactgtc aacgctttta aatcaaaagg tcgatattac 1668661 gactccaagc gtaacggtca ttccaagaag taaaatcagc gatgcgtttc ctgaaccgta 1668721 tgtagcgatt gaagtgaatt atacggaggg cttcagcgga agcaacctgt tagtcgtgga 1668781 acaaagtgac gcggcgatca ttgcggactt aatgatcggg ggagacggaa aaggtgcgga 1668841 cccttcactg ggtgaaatcc atttaagtgc ggttcaagaa gcaatgaacc aaatgatggg 1668901 atcggctgcc acatcaatgt ctactgtatt cagtaaaaaa attgatattt cacctcctcg 1668961 ggttgaattg ctggatgtta ctgaagaaaa gggtacagac cgtattcctg atgatgaaat 1669021 gctggtgaaa gtttctttca acttaaaggt gggagaatta atagactcca gcattatgca 1669081 actttaccca ttgacatttg cgaaagattt aatttcaagc cttatgaact cagaaagtgc 1669141 agaggaagaa gaaacggtgc agcctgaagt tacatacgaa cagccgaaag agcctgtgac 1669201 gccagagccg cgtattgaac cgaagcaaca gcagcagccg ccaaaaaggc agggaacagc 1669261 aaaaaaagca gcgccagttc aggtttcacc ggtggaattt tccgcgtttg atccaaacga 1669321 agctgtacaa gcccctattc ataatctgga tatgcttttg gatatcccgc tttcgattac 1669381 tgttgagctt ggcagaacga agagaagcgt aaaagagatt ttagagcttt ctgccggaag 1669441 tattatcgag cttgataaat tagccggtga gcctgtagat attttagtta atcagcgtat 1669501 cgttgccaaa ggcgaggtcg ttgtcattga agaaaacttc ggagtgagag tcactgacat 1669561 tttaagccag gcagagcgca ttaataattt aaaataacga aacacaagga gagagataga 1669621 ttatggcaca tagaatttta attgtagatg acgcagcatt tatgcgaatg atgattaaag 1669681 atattttggt taaaaatggt tttgaagttg tggcggaagc tgaaaatgga gcacaagcgg 1669741 tagagaaata taaagagcat tcacctgacc ttgttactat ggatatcacg atgccagaaa 1669801 tggatggtat tacagcatta aaagaaatta aacaaattga tgcgcaggca agaatcatca 1669861 tgtgttctgc tatgggacag caatcaatgg ttattgatgc cattcaggcc ggcgctaagg 1669921 atttcattgt gaaacctttc caggctgacc gtgtgcttga agcaatcaac aaaacattaa 1669981 attaaagggt gtacgactgt tgaaaaagag tcaatatttt attgttttta tttgtttttt 1670041 cgttttattc agtgtacatc cgattgctgc tgccgcggca gactctgata attcaactgt 1670101 aaacgaatgg tttcaaaaga aagatgaaaa aactgcagat caatcagagc aaaagaaaga 1670161 aaaaacaaca aaaactgctg atgagacgga gggagcggct gctccttctg tctcagcttt 1670221 tgattttgta aagatgattt tcgctttact gtttgttatc gtgctgattt acgggctggt 1670281 taagctcatg aacaaaagaa atcggctcct aaagcctttt caatatgttg aaaatattgg 1670341 cggcacatcg gtcggtcaga acagatccat acaattgatc aaggtcggga aaagtgtgct 1670401 cgtcgtcggt gtaggagaga cgatccagct gctgaaagaa attgaggatg aaaaagagat 1670461 tgaagtcatt ctcagtcagc atgaagaggc aatgtcaagc aaaatagagt ggcaaaagtt 1670521 tgtgaagccg cttaagagtt ctgaacatca gccgcagcaa aaactgcctt cattttcaaa 1670581 agcattaaaa gagcaacttg aagagttaaa acaaaaccgt tctgaaggaa agaagaaagg 1670641 cccacgtcat catgaatgag tttataaata ttttcagttc aagcgatccg gaaaacgtaa 1670701 gttcgactgt taaattacta ttattgttaa ctgtattttc agtggcgcct ggaatattga 1670761 ttcttatgac ttgttttact cgcatcgtca ttgttctgtc atttgtcaga acttcacttg 1670821 cgacgcaatc tatgccccca aaccaggttc taatcgggct tgcgctgttt ttaacatttt 1670881 ttattatggc tcctactttt tcagaaatta ataaagaagc gctgacccca ttaatggaca 1670941 acaaaatcag cttggatgaa gcgtatacga aagctgagga accgattaaa gaatttatga 1671001 gtaaacacac aaggcagaag gatctggcgc tgtttatgaa ttacgcgaaa atggataaac 1671061 ctgaatcatt aaaggatatt ccgttaacaa caatggttcc ggcttttgcc atatcggagc 1671121 ttaaaacagc atttcaaata ggttttatga tttttatccc ttttttaatt atagatatgg 1671181 tagtggcgag cgtcttgatg tcaatgggaa tgatgatgct gcctccagtt atgatttctc 1671241 tgccctttaa aatattactt tttgttttgg tagacggctg gtatttaatt gtgaaatctt 1671301 tgcttcagag cttttagggt aggtgctaaa cgtgagttca gaatttgtaa tttctatggc 1671361 ggaaaaagcc gtatacgtaa cgctgatgat cagcgggcca ttattggcta ttgctttact 1671421 ggtcggttta attgtcagca tatttcaggc gacaactcaa atccaggaac agactttggc 1671481 gtttattccg aaaatcgtgg cggttctcct ggctctcatt ttttttggtc cgtggatgct 1671541 gtcgacgatt ctttcattta caacagagct gttttctaat ttaaatcgtt ttgcagggta 1671601 atgtagagat gaattcaatt attgacttat ttcctgcttt tttattggtt tttattagaa 1671661 tctctgcttt ttttgtaacg attccgctat ttggacatcg aaatgtgcca gctgttcatc 1671721 gcataggttt tgcttttttt cttgcggtca tttgtttcag caccattgat aaaccgccct 1671781 ctttggagat agatgagcac tatatgcttt tggcgtttaa agaagctttg gtcggcctat 1671841 gtctgggttt aattgcttat atgatgattg ccgcagtgca gattgccggc tcgtttattg 1671901 attttcaaat gggattttca atagcaaacg ttattgatcc gcaaaccggt gcacaaagtc 1671961 cgttgattgg ccagtttatc tatacgatgg cacttttgtt tatgctgagt gtcaatgccc 1672021 accatttgtt gctggatggt atttactaca gctttcagta tatttcagtt gatcaggcat 1672081 ttccgaattt cggcgatgaa aagtttgcct attttattgc gaaaagcttt aatgcaatgt 1672141 ttattatcgc ttttcaaatg tcagcgccgg ttgtggccag tttgtttcta gttgatttag 1672201 cattaggtat cgtggctcga actgttccgc agttaaatgt atttgtggtc ggtctgcctt 1672261 taaagatcgc tgtcagtttc attatgctca ttgtatgtat gtccgttatc ttcgtcgttg 1672321 tccggaatgt tttcagttta acgattgaaa cgatgcggaa tcttttagca ttggtcggtg 1672381 tttcttaatg aagcttagag ttgacctgca gttttttgcg ggagagaaga cagaaaaagc 1672441 cactccgaaa aaacggaagg atacgcgaaa aaaagggcag gtagccaaaa gctcggatgt 1672501 caataccgcc gtttctttac tggtaatatt cctttcgctt attgcaattg gtccgtatat 1672561 gagagacagg ctgctgtcat tcatagaaac attttatacc gaatcgctca caatgaagct 1672621 ctcagaatca aatgtgcata cattgtttgt cagcttatta aaggatatgg gcatgatact 1672681 cgcaccgatc ttgcttgttg ctcttgttgc aggagtcgta agcaactata tgcaggttgg 1672741 gttcttgttt tctgctgaag tgatacagcc taagcttgaa aaactggatc cgatcaaagg 1672801 ctttaaacga atatacagta tgagggcgat tgtagagctg attaaatcaa ttttgaaaat 1672861 cgtagtcgtc ggttttgcgg cttttgctgt gctttggctg cattatggag aaattctccg 1672921 gcttcctctc ctgacacccg aagaggcact ttctttcgtt tcaaaactca ctttgtggat 1672981 gggactaagc ggtgcaggtg cattgttgat tcttgctggt ctcgactatt tatatcagag 1673041 atttgactat gagaaaaata tcaaaatgtc aaaacaagat ataaaagatg agtacaaaaa 1673101 atctgaagga gacccgatta tcaagtctaa aattaaacaa agacagcggg aaatggcgat 1673161 gaggcggatg atgcaggaag ttccaaaagc agatgtcatt atcacaaacc cgactcacta 1673221 tgcgattgct ttgaaatatg atgaagaaaa aatggacgca ccttatattg ttgcaaaagg 1673281 cgtcgaccac cttgcgttaa aaatcaggaa aattgctaaa gagcatgatg tcatgatggt 1673341 agaaaacaga ccgcttgccc gtgcgttata tgatcaagtg gaaattgacc aggcagtgcc 1673401 ggaagaattt tttaaagttt tagcagaaat tctggcttac gtatataaaa caaaacaaaa 1673461 agtatattga atttttcgat ttaaaaggag agaaaaaaca gcatgtcaac aagagattta 1673521 tccgttttaa taagtgttgt cctcattgtg gcgatgctgg tgattccatt tcctccatgg 1673581 ctgttaagta ttttgatcat tattaatatt tctcttgcgt tgatcgtgct tctcaccaca 1673641 atgaatatgc aggaagcgct tcagttttcg atttttccgt cactgttgct gcttttgacc 1673701 ctatttcgtt tgggcttgaa cgtctcaact acccgttcaa ttctttcaca cggtgaggga 1673761 ggtaaagtcg tcgagacttt cggaaatttc gttgtcggcg gaaatgtatt agttggactc 1673821 gttgtattta tcatccttat tattattcag tttatcgtca ttacaaaagg tgctgaacgt 1673881 gtttccgagg ttgcagcaag gtttacgctg gacgcaatgc cggggaagca gatgagtatt 1673941 gatgctgatt taaacgcagg gatgattacc gaacaggaag cgaagcatcg ccgcgaaaaa 1674001 gtggcaagag aagcagactt ttatggagca atggacggtg ccagtaaatt tgtaaaaggt 1674061 gacgccattg ccggaatcat cattgtgatg atcaatatta ttttcggaat cgtgatcgga 1674121 atgcttcagc agggcatgtc cattcaagaa gctgcttcac actttacgat gctgactgta 1674181 ggggatggaa ttgtttcgca aatcccggca ctgttaattt ctacggctac gggtattgtg 1674241 gtcacaagag ctgcatctga aggaaactta gggcatgaca ttacaggcca gctgtttgcg 1674301 tatccaaagc ttttatacgt cgcagcagct acgatcatgc ttttaggtat tttcactccg 1674361 atcggcatcc ttctgacggg gccgcttgcg ggattgcttg cttttggcgc atatacacta 1674421 tctaaatcag gtaaggaaaa agaagaagtg gatgagattc ttgaggaaga ggctgaggtg 1674481 gacgagctta aaagccctga aagtgttgtt cagcttctgc atatagatcc gatagaattt 1674541 gagtttggat atggcctgat accgcttgct gatgccaatc aaggcggtga tttattagac 1674601 cgaattgtta tgatacgccg tcagttggct ttggaactcg ggcttgtcat tcctgtcgtg 1674661 cgaatcagag ataatatagc gttgcagcct aatgaatacc gattgaaaat taaaggaaac 1674721 gaagtagcaa aaggcgagct gttgcttgat cattatttag cgatgtcgcc tactcctgag 1674781 gacgatctca ttgaagggat tgaaacagtg gagccttcat tcggactgcc ggctaaatgg 1674841 attagcgaag cggtaaagga tgaagccgac atgcttggtt atacagtagt tgatcctgca 1674901 tcagtcgttt caacgcatat tacggagaaa attaagcagc atgcccacga attgatcgga 1674961 aggcaggaga caaaacagct gatcgatcac ttgaaagaat cgtatccagt cctggttgaa 1675021 gaggttacgc cgaatccatt gtctgtcggt gatattcaga aagtgcttgc taagctttta 1675081 aaagaaaaag tttcaattcg aaacttagta acgatttttg aaacacttgc tgactatggg 1675141 aaattaacaa cagattctga tctcttgaca gagtatacaa gacaagcgct tgctaaacaa 1675201 attacagccc agtttgccaa agaaaatgaa gtgttgaagg ttgttacttg ttccggccgt 1675261 gtagaaaaag caatagcaga cggtgtgcag cagacggaac acgggaacta tttatcactt 1675321 gaaccagata tttcagaaag tatagtgcgc tctgtcgcca aagaagctga acagctctca 1675381 ttacgtcagg aaaccgcgat tcttctttgc tcgccgcctg tcagaatgta tgtgaagcag 1675441 ctactggaac ggtacttccc tgatcttccg gtactctctt ataacgaact tgaggcgaat 1675501 gttgaggtac aaagcattgg agtggtggat atttaatgaa aataaaaaaa tttactgctg 1675561 cttcaatgca agaagcggca cttctcatca gaaaagagtt aggtaatgaa gcggtcatat 1675621 taaattcgaa aaaaattaaa aagcgaaaat ggtttggcct cgtcaacaag cctgctgttg 1675681 aagtaatcgc cgtattggat caggactttc ttgagaaaaa aacgcctcag aaggcagctg 1675741 aaccgaaaca aacattaaaa actccggtca gcagtccaaa aatagaggag agaacatatc 1675801 cccctcaaat tccggcgcaa caggagctag gtgatttttc agcatatcaa tctgtacttc 1675861 ctgagccgct gcgaaaagca gaaaagcttt tgcaagaaac agggatcaaa gagtctacga 1675921 aaacgaacac tctgaaaaaa ttgcttcgct tctctgttga agcaggcggc ttgactgaag 1675981 aaaatgttgt cggcaaactt caggaaatac tatgcgatat gctgccctca gcagacaagt 1676041 ggcaggagcc aattcattca aaatatatcg ttctctttgg ttcaacaggg gctggtaaaa 1676101 caactacact ggctaaactc gcagccatat ctatgcttga aaaacataaa aaaatcgctt 1676161 ttattacaac agatacgtat cgtattgcag ctgttgaaca gttgaaaaca tacgctgaac 1676221 tgctgcaggc tcctctggaa gtttgctata caaaagaaga atttcagcag gcgaaggagc 1676281 tattttctga gtatgatcat gtgtttgttg atacagctgg aagaaacttc aaagacccgc 1676341 aatacattga tgaactgaaa gaaacgattc cttttgagag cagcattcag tcatttcttg 1676401 ttttatccgc gactgcaaaa tatgaagata tgaagcatat tgtcaaacgg ttttcatccg 1676461 tccctgtcaa tcagtatatt tttacgaaaa tagatgaaac gacttcctta ggttctgtat 1676521 ttaatatact ggcagaatca aaaataggtg tcgggtttat gactaacggc cagaatgtgc 1676581 ctgaggatat acagactgta tctccacttg gttttgtgag gatgctgtgc agatgaacag 1676641 atatgaccaa gcagcaactt tacgggcgaa aatggaaaaa cgtgagcgcg ttctgccaat 1676701 ggtttattca caaaaagcga agacacttgc tgtcatcagc ggcaagggcg gtgtcggaaa 1676761 atccaatatt accttaaata tggcacttgc gctgcaggat aaaggtaaga aggtgctgct 1676821 catcgacctt gatatcggga tggggaacat tgatatatta ataggaaatt catcgtctgc 1676881 cacgataatc gatgttttaa ccgatcgtaa gcctttgctg cagtcattat ccgttggccc 1676941 aaagggtttg cggtatatat cagggggaac cggtcttgat gtgatgtttc agctcgatca 1677001 gagaaaatgg acgttttttg ccaatgaact ttctcatgca ttaagccagt tcgattatgt 1677061 gctgtttgac atgggagcag gcttatcaaa agatcaactg ccttttattt tatcagcaga 1677121 agatattttg attattacaa ctcccgagcc gacggccatt atggacgcat acagcgctgt 1677181 caagcacttg gttttgacag aaaataagct ttcaatgaag gtggctgtca atcggtgccg 1677241 tgaccaaaag gaagggcttg acgcttttgc ccgcctctcc cgtacaattc atatgttttt 1677301 ggatgttcag gttcagtttg ccggttccgt ttctgacgat gtgatcgtga gcaaagcggt 1677361 tgtcgaacag gttccttttt tcataaaaag ccctcaggca aaagccagcc ggtcagtccg 1677421 tattttagcg gacgccttgt ttgaaagaga agaaacgaga cacaaagaag acaaacagac 1677481 atttattgag aaattatctt cttttttaat gaggagggct taatttgatt cgtgtgcttg 1677541 tagttgatga ttcagctttt atgagaaaaa tgataagtga ttttctgacc gaagaaaagc 1677601 agatagaagt aatcggaact gcgagaaacg gagaagaagc gcttaagaag attgaattat 1677661 taaaaccgga tgttattact cttgatgttg aaatgccggt catgaatggg acagatacgc 1677721 tccgcaaaat tattgagatt tataacttgc cggtcattat ggtgtctagc cagaccgaga 1677781 aaggtaaaga atgcacaatt aattgtttgg agatcggtgc ctttgacttt atcacaaagc 1677841 catcaggctc aatatctctg gatctataca aaattaaaga acaactagtt gagcgtgtcg 1677901 tcgcggcagg actttccggc aagcggaaac gtcctgtttc ccagacagtt cggcccgaac 1677961 ctattgtgcg tgctgtcgtt aagcctgaat taagcaaacc gaaacctggc acgggcagac 1678021 aaattgtgtg tatcggcaca tcaacaggcg gtccacgggc gttacaaaag gtgataccga 1678081 agctccctaa ggatttgaac gcaccagtgg ttgtcgttca gcacatgcct gaagggttta 1678141 ctgcttcttt ggctgatcgg ctgaatcatt tatctgacat tcaggtaaaa gaagcaaaag 1678201 atggtgaagc agctcttaac ggctgtgttt acatagcacc gggcggaaaa aacatatccg 1678261 ttattaaaaa cagcgaagga ctccaggttg tgcttgataa ccatgacaca ccaagccgtc 1678321 ataaaccatc tgctgattat ttattccgtt ctgtcgggaa actgacagat tatgaaaaag 1678381 tagcggttat catgaccgga atgggcagtg acggcactgc tggactaaag gacatgctaa 1678441 cagccggcaa tgtgaaagcc attgcggagt ctgaagaatc ttgtgtcgta tacgggatgc 1678501 caaaagctgc tgttaaagcg ggtctcattc atgagattaa acatgtggaa gatatcgcag 1678561 catccatcac aagctgtgtg aaaaaagaga gggtgtgatt caaatggata tgaatcagta 1678621 tttagatgtc tttattgatg agagtaaaga acatttacaa acatgtaatg aaaagcttct 1678681 tcttttagag aaagacccga ctgatcttca gctcgtacat gatatattca gggctgccca 1678741 tacattaaaa ggaatgagcg caacgatggg ctacacggat ttagcacatc ttacccatct 1678801 gcttgaaaac gtgctggatg caatccgaaa cggagacatg gaagtcacct cagactggct 1678861 ggatattttg tttgaagctc tggatcacct ggaaacaatg gttcagtcta ttattgatgg 1678921 cggggatggt aaaagagata tctcagaagt gagtgccaag cttgatgtga atggtgcgca 1678981 cgctgaatcc gctgcctccg ctgaacctgc agaagcacag agttcagcat ctgattggga 1679041 atatgatgaa tttgaacgca cagttataca agaagcggag gagcaaggct tcaaacgata 1679101 tgaaatcaag atttctctga acgaaaactg tatgttaaaa gcagttcgtg tctatatggt 1679161 gtttgaaaaa ctaaatgaag tcggagaagt agccaaaaca attccaagtg ctgaagtgct 1679221 tgaaacagaa gattttggaa ctgactttca agtttgtttc ttaacacatc aatcagcgga 1679281 agacattgaa caattaatca atggcgtgtc ggaaattgag catgttgaag tcattcaagg 1679341 ggctccttta acatcagctg aaaagcctga agaatctaag caagaagatt caccagcagc 1679401 agctgtacct gcgaagcagg agaaacaaaa acagcctgct aaaaacgatg aacaggcgaa 1679461 gcattcagcc ggcggatcta aaacaattcg tgtcaacatt gacaggcttg attctttaat 1679521 gaacttattt gaagagcttg tcattgaccg cgggcgtctc gagcagattg cgaaagagct 1679581 tgagcataat gaactgactg aaacggttga acgaatgacg agaatttccg gagatttgca 1679641 atcgattatt ctgaatatga gaatggtccc ggttgaaact gtttttaaca gattcccgag 1679701 aatgattcgc cagcttcaga aagagctgaa taaaaaaatt gaactctcga tcatcggtgc 1679761 ggaaactgaa ctggatcgta cagtaattga tgaaatcgga gatccactcg ttcacttgat 1679821 cagaaacagt attgaccatg gtatcgaggc gccggaaaca cgtttgcaaa agggaaaacc 1679881 ggaatcagga aaagttgtgc ttaaagctta tcacagcggc aaccatgtct ttatcgaagt 1679941 agaggatgac ggcgcaggcc ttaatcgaaa aaaaattctg gaaaaagcgc ttgagcgcgg 1680001 ggtcataacg gaaaaagaag ctgaaacctt agaagacaac caaatttacg aattgatttt 1680061 tgctccgggg ttctcaactg ctgaccaaat ttctgatatt tccggccgcg gtgtaggact 1680121 tgacgttgta aaaaacaaac tggagtctct tggcggttca gtcagtgtga aatcagccga 1680181 gggtcaaggc tctctattca gcatccagct gccgcttacc ttgtctatta tttcagttct 1680241 gctgattaag ttggaagaag agacatttgc cattccgatt tcttcaatca ttgagacagc 1680301 agttattgac agaaaagaca ttttgcaaac gcatgaccgt gaagtgattg actttagagg 1680361 gcatattgtc cctgtcgttt atttaaaaga agagtttaaa atagaagata caagaaaaga 1680421 tgcggaacag ctccatatca ttgtcgtgaa aaaaggcgac aaacctactg catttgtggt 1680481 ggactccttt attggccagc aggaagttgt gctgaaatca ctcggagatt atttaacaaa 1680541 cgtctttgca atttccggag ctactatttt aggagacgga gaagtagcgc tcattattga 1680601 ttgtaatgca ctgattattt aaccattcga ggaggtgtct cacatgactg cagaaattaa 1680661 aacaggcgaa aaaatgatag tctttatggt aaatggcaaa gaatatgcca tttccgtcac 1680721 tcaggtgaaa tcaattgaaa aatggcaaaa gccaacgagg gtacctggcg tcgaaccata 1680781 tatttgcggg gtaatcaatt tacgcggggt ggtgactccg gttattgatt taagaaaacg 1680841 cctgaatttg ccagagtatg aaattacaga tgaaacacga attatcatta ttgcttatcg 1680901 tgatattgaa gtcggctgga ttgtggatga agcgaatgat gtgattaccg tacacgaaag 1680961 tgaaatagaa tctgctccag aaggcgttca gaaagatacg gatgtgtcga tcgaacagat 1681021 tgtgaaacaa gagaacagac tcttaaatat tattgatgcg aacgcggttt tggataaaga 1681081 atcatctcag tccgctgtgc ccgatcaagc ttaatcttaa aggggttatg acatgagtat 1681141 ttttaatgga atcaaagaag agcagatgga cattttgcgg gaagtcggca atataggcgc 1681201 cggccactcc gcctctgcaa tggcccagct gttaaataga aagatagata tggaagtccc 1681261 atttgcaaag ctgctgtctt ttgatgagct tgttgatttt ttcggcggcg ccgatgtccc 1681321 ggttgccagc atctttttaa gaatggaagg cgatttaacg ggttcaatgt tctttataat 1681381 gccttttttt caggcggagc agtttatcag agagctgatt ggaaaccccg attttgacat 1681441 agaggactta ggtgaagacc acatgagctc atccgctttg catgaactgg gcaatatttt 1681501 agcggggtca tatttaacag ctttggcgga tttgacgaaa ctccagctct atccaagtgt 1681561 tcctgaagtc tcattggaca tgttcggagc tgtgatcagc gaagggctga tggagctcag 1681621 tcaggttgga gaacacgcca ttgttgtcga cacgtcaatt tttgaccaaa gccatcagca 1681681 ggagctgaaa gcgcatatgt ttatgctgcc ggactatgat tcatttgaaa agctctttgt 1681741 cgccttaggt gcatcattat gagtacaact gaggctgttg ttataaaggt tgggattgct 1681801 gacgtgaaga tcgcccgctt cccggatacc atccggacct ctggtttggg ctcatgtgtg 1681861 gggctggtgc tttatgataa agaaaagcaa acggcgggtc ttgttcatgt catgcttccg 1681921 gattcgacgt tatcgaaaac tgccgagctc aaccgggcta agtacgctga caccgccgta 1681981 cagaccacga ttgatatgct gatagaagcg ggatgccgga aatttgcatt aaaagcaaag 1682041 ctggccggcg gatcagagat gtttaaattt aaatcgacaa atgatttgat gaagatcgga 1682101 ccgagaaatg tattagcgat aaaagaacag ctgtctttat ttaatattcc tattattagt 1682161 gaagatacgg gcggctcaag cggccggacg atagaatttg aaccgaagtc ctgcatgctg 1682221 catattcgaa ctgttaaaca aggtgaaaaa acgatttaat taaggtatta gggggataac 1682281 aatgcaatcc ttgaattatg aagatcaggt gctttggacg cgctggaaag agtggaaaga 1682341 tcctaaagcc ggtgacgact taatgcgccg ttacatgccg cttgtcacat atcatgtagg 1682401 cagaatttct gtcggactgc cgaaatcagt gcataaagac gatcttatga gccttggtat 1682461 gcttggttta tatgatgccc ttgaaaaatt tgaccccagc cgggacttaa aatttgatac 1682521 ctacgcctcg tttagaattc gcggcgcaat catagacggg cttcgtaaag aagattggct 1682581 gcccagaacc tcgcgcgaaa aaacaaaaaa ggttgaagca gcaattgaaa agcttgaaca 1682641 gcggtatctt cggaatgtat cgcccgcgga aattgcagag gaactcggaa tgacggtaca 1682701 ggatgtcgtg tcaacaatga atgaaggttt ttttgcaaat ctgctgtcaa ttgatgaaaa 1682761 gctccatgat caagatgacg gggaaaacat tcaagtcatg atcagagatg acaaaaatgt 1682821 tccgcctgaa gaaaagatta tgaaggatga actgattgca cagcttgcgg aaaaaattca 1682881 cgaactctct gaaaaagaac agctggttgt cagtttgttc tacaaagagg agttgacact 1682941 gacagaaatc ggacaagtat taaatctttc tacgtcccgc atatctcaga tccattcaaa 1683001 ggcattattt aaattaaaga atctgctgga aaaagtgata caataatgaa tttcatggtt 1683061 agcgagtgaa aaacatgtca acactattat ggcttttaag ctttatgctc cacggcgttc 1683121 ttctgtacgc tgtcattatc ctgtatacga ggctcgctgc agtgaaagaa acagaaaaac 1683181 agcaaaaaca gatacttgaa gagacggaaa acaccttggc ggcatttctg cttgaattaa 1683241 aagaagaaaa tgagaaactg atagaaaata aagcttcatc tgcaagtcaa tcagatgaag 1683301 aatcccaaaa gtcaggcctt cagacctctg aaacatatca agagcgggat ccagtccaag 1683361 aggcagagaa tcttcctgaa catattgaag gtctgattac agaggttgac cgtcgggaag 1683421 agctcgtaaa cagtgaggtc caatcatttg aagaccaggt catagaatta tatgaacagg 1683481 gatattcggc aagtcaaatt gcccagaaaa tgaagagcgg aaagacagaa atcgagctat 1683541 ttttaaaatt tcgctccaaa ggtgtaaagg attcttgatt gtcggataaa gctgtgttat 1683601 attatgtctt ggtgttaaat acacacgctt aacgatttat gcagagggtg ctgcaggcgg 1683661 cagttctgta caaaaatgac ctaagcggag gaaaaaaacc attatattag gaggaaataa 1683721 catgtcagtc atttctatga agcaattgct tgaagctggt gttcacttcg gtcaccaaac 1683781 acgccgttgg aacccaaaaa tgaagcgtta cattttcacg gagcgtaacg gaatctacat 1683841 cattgacctt caaaaaacag tcaaaaaagt agaggaagct tacaacttca ctaaaaatct 1683901 tgctgctgaa ggcggaaaaa tccttttcgt cggaacaaaa aaacaagctc aagattctgt 1683961 taaagaagaa gctcaacgct ctggcatgta ctatgtcaac caacgctggt tgggcggtac 1684021 attaacaaac ttcgaaacaa tccaaaaacg tattaaacgt cttaaagaca ttgaaaaaat 1684081 gcaagaaaac ggtacgtttg atgtacttcc taaaaaagaa gtcgttcaat tgaaaaaaga 1684141 attagagcgt cttgaaaaat tcctaggcgg aattaaagat atgaaggatc ttcctgatgc 1684201 attattcatc atcgatcctc gcaaagagcg catcgctgtt gcggaagctc gcaaattaaa 1684261 catccctatc atcggtatcg tagatactaa ctgtgatcca gatgaaatcg atgttgttat 1684321 cccagcgaac gatgacgcta tccgcgctgt taaacttcta acttctaaaa tggcagatgc 1684381 aatcttagaa gcgaagcaag gcgaagaaga agcggaagtt gctgaagaaa ctgcaccaga 1684441 aacagaaaca acaactgcgt aacctattca aaaggtgata agagggactg ccttttatca 1684501 ccttttttca agaaaaatgt gtaatataca tactcttgtt taaacatata aggaggaata 1684561 caaatggcaa ttactgcaca gcaagtaaaa gaactgcgtg aaaaaactgg cgcgggcatg 1684621 atggattgta aaaaagcgtt aactgaaact gacggagata tggacaaagc aattgacctt 1684681 ttaagagaaa aaggaattgc aaaagcagcg aaaaaagctg accgtatcgc agcagaaggt 1684741 tctactctta ttaaaactga cggcaacaaa ggcgttatcc tagaagtaaa ctctgaaact 1684801 gatttcgttg cgaaaaacga aggttttaaa gagcttctta acactttagc tgaccacctt 1684861 cttgcaaaca cgccagctga tgttgaagaa gcaatgggcc aaaaaatgga aaatggctca 1684921 actgttgaag agtacatcac aagcgcagtt gctaaaatcg gtgagaaaat cactcttcgc 1684981 cgctttacag ttcttacaaa agacgacagc tctgcattcg gtgcgtacct tcacatgggc 1685041 ggccgcatcg gtgtattaac tgttctcaac ggtacaactg atgaagaaac tgcgaaagat 1685101 atcgcaatgc acgttgctgc agttaaccct cgttacattt ctcgtgatca agtatctgaa 1685161 gaagaaacaa atcatgagcg tcaaatctta actcagcaag ccctccaaga aggcaaacct 1685221 gaaaacatcg tagcgaaaat ggttgaaggc cgtctgaaca aattcttcga agaaatttgt 1685281 ctattagacc aagcgttcgt taaaaaccca gatgaaaaag tgaaacaagt tattgcagcg 1685341 aaaaacgcta ctgttcaaac ttttgtccgc tatgaagttg gagaaggcat cgaaaaacgt 1685401 caagaaaact ttgctgaaga agtaatgaac caagtgaaaa aataatggtg aaaagatttc 1685461 gcggctaagt cgcgtctttt caggcagtat aggggacaca ttttgtgttc cctattttta 1685521 aaactatatt tacaaacctt tttttctctt gcataataga aaacggcaat gtttacactt 1685581 ggaggttatc atggaaaaac caaaatacaa acgtatcgta ttaaagctta gcggggaagc 1685641 attggcagga gaacagggaa atggaattaa cccgactgtc attcaatcca ttgcaaagca 1685701 agtgaaggaa atcgctgagc ttgaagtcga agtggctgtt gttgtaggcg gcggcaactt 1685761 atggcgcgga aaaacaggaa gtgacctggg catggaccgc gcgactgctg actatatggg 1685821 aatgctggcg acagtaatga attcgcttgc tcttcaagac agcttggaaa cactcggaat 1685881 ccagtccaga gtgcaaacat ccattgaaat gagacaagtt gctgaaccgt acataagaag 1685941 aaaagcgata cgccacttag agaaaaaacg tgtcgttatt ttcgctgcgg gcacaggaaa 1686001 cccatatttc tcaactgata cgacagctgc actgcgggct gctgaaattg aggcagacgt 1686061 tattttaatg gctaaaaata acgttgacgg tgtgtataat gctgatccta gaaaagatga 1686121 atcagctgtt aagtatgaat cactttctta tcttgacgtt cttaaagacg gcctggaagt 1686181 catggattca acagcttcct ctttatgcat ggacaatgac attccgctta tcgtcttttc 1686241 tattatggaa gaaggaaata tcaaacgtgc cgttatcggt gaatcaatcg gaacgatcgt 1686301 gagggggaaa taacgtgtca aaagaagtat taactcaaac aaaagaaaaa atggaaaaag 1686361 caattgctgc ttatcagcgc gaattggcta ctgtacgcgc aggccgtgca aatccatcat 1686421 tattagataa agtaacggtt gaatattacg gagcgcagac acctttaaat cagttgtctt 1686481 ctattaacgt gcctgaagct cgtatgctcg ttatcacgcc atacgataaa acagcaatcg 1686541 gtgatatcga aaaagcgatt ttaaaagctg atttaggtct tacaccaaca agtgacggca 1686601 atatgattcg aattgcaatt ccggcactaa cagaagagag acggaaagaa ttagtgaaag 1686661 ttgtaaaaaa atatgctgaa gaagcaaaag tagctgttcg taacgttcgc cgtgatgcta 1686721 acgatgatct caaaaaactt gagaaaaacg gagacattac tgaggatgaa ctgcgtgctt 1686781 ccactgaaga cgttcaaaaa ctgacagatg aatatgtgtc aaaaattgac agtgtcacaa 1686841 aagacaaaga aaaagaaatc atggaagttt aatgaaaaac tatgtacaat agataatagt 1686901 gaaaagaccc tctcatgttt acagggggtt tttttgttaa tactgttgat tacattgatt 1686961 atcagcaggg aatgtaacct ttttgggtga cggaggaatc tcatgctcaa catactcaaa 1687021 aattggaaga atcagcaaac tgcggcttcc aacttagaac gttatacaaa agaagacata 1687081 cttaagggag aaattcccga acacatcgcc attatcatgg atggaaatgg ccgttgggct 1687141 aaaaaacgct ctcttcccag aattgcaggc caccatgaag ggatgaaggt ggtaaaaagg 1687201 accacgaagc tcgcaaacga attaggtgtc aaagtactga cattgtatgc attttcaaca 1687261 gaaaactgga aaagaccgaa aatggaggtc gattttttaa tgaagcttcc ggaagaattt 1687321 ttgaatacgt atcttccaga gcttgttgag gaaaatgtac aggttcggat cattggggat 1687381 gaaacggctt tgccggcgca cacattacgt gcgattgaaa aagctgtaca ggacacggcg 1687441 caaaacgacg gaatgatcct taattttgct cttaactatg gaggccgtac tgaaattgtc 1687501 agtgctgcaa aatcactcgc ggaaaaagtg aaggaaggct ctttgaatat tgaagacatt 1687561 gatgaatcgc ttttttctac ttatttgatg actgaatctt tgcaggatcc tgaactttta 1687621 attcgaacga gcggcgagat aaggctgagt aattttatgc tatggcaggt tgcctacagt 1687681 gaatttgtct ttactgacgt cttgtggcct gactttaaag aagatcactt cttgcaggcg 1687741 ttaggagagt ttcagcagag aggccggagg tttggcggaa tttagaggat ggtggacatg 1687801 aaacaaagaa ttttgacagg tgttctggca gcaattgtat ttttattttt ggttattgtc 1687861 gggaaattgc cgttcaccat attaatttat gctatgggca gtgtggcgct ttttgaactt 1687921 ttacggatga aaaagctgaa gctggtttca ctgccgggtt tgatcggtct tttattattg 1687981 tggatgttct tattaccaag ccagtattcg ttttttgaag cggacgggat ttccaaaatg 1688041 gaaatcgctt tatttgcggt actgctattg ctgacttaca cagtgttggt caagaacacc 1688101 tttacttttg atgaagtcgg gtttattacg cttgcagcaa tttacatcgg aatgtgtttt 1688161 cattatttta tcgaaatcag aaatcttgac caatacggat taacatacat tttttatgcg 1688221 tgtgttgtca tttggtccac cgattccggt gcctattttg tcggtaaatc gcttgggaag 1688281 cggaaactgt ggcctgaaat cagtccgaat aaaacagtgg aagggtttgc aggcggaatt 1688341 gtcatcgcac ttgtattggc gacgattttt cagcttgttg cacaacttcc gatcccgtat 1688401 atctatctgc tgttgatcac gctgtttttg tctgtttttg gacaactggg agatttagtg 1688461 gaatccgcct tgaaaagaca ttacgatgta aaggattctg ggaatattct tcccgggcat 1688521 ggcggtatat tagaccgttt tgacagtttc ttgtttgtca tgcctttctt gtactttctg 1688581 cttgcccttt tttcataaaa aagtctaata tgaatatgag actgatcatg cagcaataag 1688641 aataggagta gtggcaactt tgaaaaatat ttgtctttta ggagcaacag gatcaatcgg 1688701 cgaacagact cttgatgtac tgcgtgcaca tcaagaccaa tttcagctgg tatctatgtc 1688761 gtttggcaga aatattgata aggccgttcc aatgattgag gtctttcagc cgaagtttgt 1688821 ctctgtcggt gatctggata catatcataa attaaaacaa atgtcttttt cttttgaatg 1688881 ccaaatcggg ctgggagaag aaggactgat agaagcagca gtgatggagg aggttgacat 1688941 tgttgtcaac gctttgcttg gaagcgtcgg tcttatcccg acattaaagg caattgaaca 1689001 gaaaaaaaca attgcgcttg caaataagga aactcttgtc actgcagggc atatagtaaa 1689061 agaacatgct aagaaatatg atgttccgct gctgcctgtt gacagtgagc attcagccat 1689121 ttttcaagct cttcaaggcg aacaggctaa aaacattgaa cgcctcatca ttacggcatc 1689181 cggcggaagt tttcgggaca agacgcggga ggagctcgaa tcagtaacgg ttgaagatgc 1689241 attaaaacat ccaaactggt caatgggtgc aaaaattaca attgattcgg ctacaatgat 1689301 gaataaggga ttagaggtga tcgaggcaca ctggcttttc gatatacctt atgaacaaat 1689361 tgatgtggtt ttacataagg agagcatcat ccattcaatg gttgagttcc atgataaaag 1689421 tgtgatcgca cagctcggaa ctccggatat gagagtcccc attcaatatg cgctcactta 1689481 tcctgaccga ttgccattac cagatgcgaa aaggcttgaa ttatgggaaa tcggcagcct 1689541 tcattttgag aaagctgatt ttgacaggtt ccgatgctta caatttgctt ttgaatcagg 1689601 taaaatagga ggaacaatgc cgacagtgct aaatgcggca aacgaagtag ctgtcgctgc 1689661 ctttttagct ggcaagatac cgtttttggc tattgaagac tgtatcgaaa aggcactaac 1689721 ccgccatcaa ttactgaaaa aaccgagcct ggcggacatt caagaagtgg acaaagatac 1689781 ccggggatac gtcaattcaa tactcacata aggtggtatg ttcgtgaata cagttatagc 1689841 gtttatcatt attttcggaa cgctcgtttt cttccatgaa ctgggccatt tattgctagc 1689901 ccaaagagcg ggaattctct gccgtgaatt tgcgatcggc ttcggtccaa agattttttc 1689961 tttcaaaaaa aatgaaacag tttatacgat caggctgctt ccggtcggcg gatttgttcg 1690021 tatggccggc gaagatccgg aaatgattga ggtgaaaccc ggatacacgg tcgggcttct 1690081 gtttaataag gaagatcaag ttgagaaagt catcatcaat caaaaggaaa aatatccgga 1690141 tgctttagtc attgaagtgg aaacagcgga tctagagcat gacatgaaga tcaccggtta 1690201 tgaacagggg aaagaggacg aactttccag ctttactgtc agcgaaacat ccttttttat 1690261 tgtagacgga gaagaagtgc agattgcgcc gtataatcgc caatttggtt ccaaacctgt 1690321 atggcagcgg attaaagcaa ttgctgcagg gccgattatg aactttattt tagcttacgt 1690381 cattttagtg atgcttgggc tgattcaagg cgtaccgtca aatgaaccta tgctcgggca 1690441 gctgacagac aatggacggg cggctgaagc agggctaaaa gaaggggatt atatccaaag 1690501 cattaacgga gagaaaatga ggtcttggac tgacattgtc tccgctgtaa aagaaaaccc 1690561 ggagaaagaa atggacgttg cagtaaaaag agataacaaa acgcttcata tttcggtgac 1690621 tccggaagct gttaaagatg agaacaaaaa aacaatcgga cgtttcggtt cctatgcgcc 1690681 gactgaaaaa ggcgtactct cagcggttgc ttacggcgcg acatcaacag ttgatgtcac 1690741 caaagccatt ttaaccaatc tgagcaaatt agtaacaggc caatttaaac tcgatatgct 1690801 gtcaggtcct gtcggcatat atgacatgac agaccaagtg gcgaaaacag ggatcgtgaa 1690861 cttatttcag tttgcggcgt ttttaagcat taaccttggg attgtcaacc tgcttccgat 1690921 tccggcactt gacggaggaa gactgttgtt tctatttatt gaagcgattc ggggcaaacc 1690981 gattaacagg gaaaaagaag catttgttgt gtttatcgga gtagctttct taatgcttct 1691041 tatgctggtt gtcacatgga acgatatcca gcggctgttt ttgtaaacga aaagtaaatc 1691101 aatcagaggt gcgaagaaat gagacaaagc ttgacgctta ttcctacgct ccgtgaagtt 1691161 ccagctgatg ccgaagcaaa aagtcatcag cttcttctga gagcaggatt tatcagacag 1691221 aatacgagcg gggtatacag ctatatgcct cttgcgtata aggtgattca aaacattcag 1691281 cagattgttc gagaggaaat ggagaaaatt gatgccgtag aaatgctcat gcccgcattg 1691341 cagcaggcag agacatggca ggaatcaggc agatggtata cgtatggtcc cgaactgatg 1691401 agactaaaag accgtcatgg ccgtgaattt gctttagggg caacgcatga agaggttatc 1691461 acttcgcttg ttcgcgatga ggttaaatct tataagcgtc tccctctgac tctttatcaa 1691521 attcagtcta agttcagaga tgaaaaacgt cctcgcttcg gtttgttaag aggccgcgaa 1691581 tttattatga aggatgcgta ctctttccat gcatctgcag agagcctgga tgaaacgtat 1691641 caaaaaatgt acgaggccta ttctaatatt tttgcccgct gcggcattaa tgtaagacct 1691701 gttatcgctg attcaggcgc aatgggagga aaggatacgc acgaatttat ggcactttct 1691761 gcgatcggag aggatacgat tgcgtattct gatgaatcac agtacgcggc taatatcgag 1691821 atggctgaag ttcttcacca ggaagttcct tcagatgaag agcctaaagc tctagagaag 1691881 gttcatacgc ctaacgtgaa aacaatcgaa gaactgactg cgttcttaca ggtttcggct 1691941 gaagcgtgca ttaagtcagt attgtttaaa gctgatgacc gttttgtctt agtgcttgta 1692001 agaggggatc atgaagttaa cgatattaaa gtgaaaaact tgcttcatgc agaagttgta 1692061 gagcttgcta cacatgaaga ggtcattcag cagctcggaa cagagccagg ctttgtaggc 1692121 cctgtcggta ttcatcagga tgtggaagta tatgccgatc aagctgtgaa agcaatggtt 1692181 aatgctgttg ccggggcaaa tgaaggagat catcattata aaaatgtcaa tgtgaatcgt 1692241 gacgcgcaaa ttaaagaatt tgctgatctt cgttttatta aagaaggtga tccttcacca 1692301 gacggcaagg gaacgatccg ttttgctgag ggaatcgaag tcggacaagt ctttaagctc 1692361 ggaacacgct attcagaagc gatgaatgcg acatatttag atgaaaacgg acgcgcgcag 1692421 ccaatgctga tgggctgtta cggaatcggt gtgtcaagaa cgctttctgc tattgctgaa 1692481 cagcatcacg acgaaaaagg cttaatatgg ccaaaaagcg ttgcgccgta cgatcttcat 1692541 attcttgctt tgaacatgaa aaacgatggg caaagagagc ttgctgaaaa gctgtatgcc 1692601 gatttaaaag cggaaggcta tgaagtgctc tatgatgacc gtgctgagcg tgccggcgta 1692661 aaattcgctg attcagattt aatcggcctt ccaatccgca tcactgtcgg aaaacgagct 1692721 gacgaaggaa tcgtcgaagt gaaaattcgt caaactggtg agtcaactga gatttcagta 1692781 gacgaattat ctgcgtttat cagcaagcag taatcaccat aacgatttat caaaaaacat 1692841 gttaaaatag aaataataga aggtacctca ttgcctgagg taccttcact tatgatgttt 1692901 ttagggaggg atactgtctt aatggaacag ttatcagtaa acagaaggca gtttcaaatt 1692961 cttctgcagc agattaatat gacagatgat accttcatga catactttga acatggcgag 1693021 attaaaaagc tgacaattca caaagcttct aagtcttggc attttcattt tcaatttaaa 1693081 tctttgctgc cttttcaaat atatgacaca ttaacaacga ggctgacgca atcgtttgcc 1693141 cacatagcaa aagtgacatc ttcaattgaa gttcaggatg ccgaggtcag tgaaagtatc 1693201 gttcaagact actggtcacg ctgcattgaa gaactgcagg gcatttcgcc gccgattatc 1693261 agtcttttaa accagcaaaa accgaagctg aagggcaata aactgattgt caaaaccaaa 1693321 acagatacag aagcggctgc gctaaagaac aaatacagtt ccatgattca agcagaatac 1693381 cgtcaatttg gctttccgga tcttcagctt gatgctgaaa tatttgtatc cgagcaagaa 1693441 gttcaaaagt ttcgggagca aaagcttgcg gaagaccaag agcgggctat gcaggccttg 1693501 attgaaatgg agaagaaaga taaagaaagt gatgaagacc aagcaccatc tggtcctctt 1693561 gttatcggtt atcaaattaa agataacgag gaaatccgaa cacttgacag catcatggac 1693621 gaagaacgga gaattacggt ccaaggttat gtgtttgatg tggagacgcg cgagctgaag 1693681 agcgggcgca cgctgtgtat cttcaaaatt acagactata caaatagtat tttgatcaaa 1693741 atgtttgcac gtgaaaaaga agatgcggcg ctgatgaagt ctctgaaaaa aggaatgtgg 1693801 gtaaaagcac gcggaagcat tcaaaatgat acatttgtca gagaccttgt catgatcgca 1693861 aatgacgtaa acgaaataaa agcaaaaacc cgtgaagatt cagcacctga aggagaaaaa 1693921 agagtggaat tgcatcttca ttccccaatg agccaaatgg atgctgttac gggtatcgga 1693981 aagcttgtcg aacaggcgaa aaaatggggg catgaggcca tcgctttgac cgaccatgct 1694041 gtcgttcaat ccttccctga tgcgtattct gcggccaaaa agcatggaat taaaatgatt 1694101 tacgggatgg aagcgaatct cgtggatgat ggcgtgccaa ttgcttataa tgccgcacat 1694161 cgtctgctcg aagaagaaac atatgttgtt tttgacgttg agacgacagg attgtctgct 1694221 gtatacgata ccattattga gctggctgca gtaaaagtaa aaggcggaga aattattgat 1694281 aaatttgagg cgtttgcgaa cccgcatcgt ccgctttccg ccacaatcat agagctgaca 1694341 gggatcacag atgatatgct acaagacgct ccggatgtcg tagatgtaat aagagatttc 1694401 agagaatgga ttggcgatga tattcttgtc gctcataatg caagctttga tatgggattc 1694461 ttaaatgtag cctataaaaa acttcttgaa gtcgaaaaag ctaaaaaccc agtcattgat 1694521 acgcttgaac ttggacgttt tctctatccg gaatttaaga accaccggtt gaacacactt 1694581 tgtaaaaagt ttgatatcga gctcacacag catcaccgtg cgatctatga tactgaggca 1694641 accgcttatt tgcttctgaa aatgctgaaa gacgcagctg aaaaaggtat tcagtaccat 1694701 gatgagttga atgaaaatat gggtcagtcc aatgcttatc aaagatcaag accgtatcat 1694761 gcaacattac ttgccgtgaa cagcacggga cttaaaaatt tatttaagct tgtgtcactt 1694821 tctcatattc attattttta cagagtgccg cgtattccga gatctcagct tgagaaatac 1694881 agggaagggc ttctgatcgg ttctgcttgt gacaggggag aggtttttga gggaatgatg 1694941 caaaaatcgc ctgaagaggt ggaagatatc gcgtcattct atgattacct tgaggttcag 1695001 ccgcctgaag tgtatcgtca cttgctggag cttgaactgg tccgtgatga aaaagcgctg 1695061 aaagaaatta ttgcgaatat cacgaagctg ggggaaaagc ttaataaacc ggttgttgct 1695121 acgggaaatg ttcattactt gaatgatgag gataaaatct acagaaagat tttaatatcc 1695181 tcacaaggcg gggcaaatcc gctgaatagg catgaactgc cgaaagtgca tttcagaacg 1695241 acagacgaaa tgcttgaagc tttttctttc ttaggtgaag aaaaagcgaa ggagatcgta 1695301 gtcaccaata cccaaaaggt tgcttcttta gttgatgaca tcaagccgat taaagatgat 1695361 ttatatacgc cgaaaatcga aggcgctgat gaagagatca gagaaatgag ctatcagcgt 1695421 gcaagaagca tttacgggga agagctgcct gaaattgtcg aagcgcggat tgaaaaagag 1695481 ttaaagagta ttattggcca cggatttgct gttatttact tgatctctca caaacttgta 1695541 aaacgttcac tagatgacgg gtatctcgtt ggttcccgtg gttccgtagg atcttcatta 1695601 gttgcgacac ttactgagat tactgaggta aacccgctgc cgccgcacta tgtttgtcct 1695661 gagtgccagc attctgagtt ctttaatgac ggttctgtcg gttctggttt tgacctgcct 1695721 gacaagacat gccctcattg cggaacgcct ttgaaaaaag acggccatga tattccattt 1695781 gaaacgttct taggatttaa aggggacaaa gtacctgata tcgatttgaa cttctcaggg 1695841 gaatatcagc cgcaagcaca caattacaca aaagtattgt tcggagaaga caatgtatat 1695901 cgtgcgggaa caataggcac ggtggcagaa aaaacagcct acggttatgt aaaaggctat 1695961 gccggagaca acaatcttca tatgcgcggt gccgaaatag atcggctcgt acagggatgc 1696021 acaggtgtaa aacgtacaac tggacagcac cctggcggta ttatcgtagt tccggattat 1696081 atggatattt atgatttttc accgatccag ttcccggcag atgccacagg ttcagagtgg 1696141 aaaacgactc attttgattt ccactccatc catgacaacc tgttaaaact tgatattctc 1696201 ggacacgatg acccgactgt tattcggatg cttcaagact taagcggaat agatccgaaa 1696261 acaattccga cggatgatcc tgaagtgatg aagatcttcc agggaaccga atcactcggt 1696321 gtgactgaag aacagattgg ctgtaaaacg ggcactcttg gaattcctga attcggaacc 1696381 cgatttgtcc ggcagatgct tgaagataca aagccgacca ctttttctga gctcgttcag 1696441 atttcaggct tgtctcacgg aactgatgta tggcttggca atgcacagga gctcatccac 1696501 aataatattt gtgagctgag tgaggttatc ggctgccgtg atgacattat ggtttattta 1696561 atctatcaag gccttgagcc gtcccttgcc tttaaaatca tggaattcgt gcgtaaagga 1696621 aaaggattaa cgcctgaatg ggaagaagaa atgaaaaata acaatgtccc agactggtat 1696681 attgattcct gtaaaaagat taaatacatg ttcccgaaag cccacgccgc ggcatatgtc 1696741 ttaatggcag tccgcattgc ttactttaaa gtgcatcatg ctcttttgta ttatgcggct 1696801 tattttaccg ttcgtgcaga tgactttgat attgatacaa tgatcaaggg ctctacagca 1696861 atcagagcgg taatggagga tataaacgct aaaggacttg atgcttcacc gaaggaaaag 1696921 aaccttctga ctgttttaga attagcgctt gagatgtgtg agagaggcta ttcattccaa 1696981 aaagtcgatt tatatcgctc cagcgccaca gagtttatta ttgacggcaa cagtcttatt 1697041 ccgccgttta actctattcc agggttaggg acgaacgctg ctttgaacat tgtaaaagct 1697101 cgcgaagaag gcgaattcct ctcaaaagaa gatttgcaaa agagagggaa agtatcaaaa 1697161 acgattttag agtacttaga tcgccatggc tgtctggagt cactgcctga tcaaaaccaa 1697221 ttgtcactgt tctaatatgg aaagcagaat ttctcagaaa ttctgcttct atgcatacat 1697281 aagcgcaaaa agtgccatcg taatattaga gtttctgtca cttgcttagg tatgaaggta 1697341 agcgtatatc catttgcaat aaaaatatgg ttatggtata gttttattgg aaatgctaac 1697401 gattaccgag gcaaagagtg gggaaacccg ctcttttgta ttgaacagga gaattttgtc 1697461 tcgacatgtt catcgtttac tttttagccc ctgctctttt gaagcagggt ttttatgcag 1697521 agtgacgaga cgaatatgag atcgacagca caaggaggaa gaacatgagc aaaaaagtga 1697581 ctgacaccgt tcaagaaatg gctcagccaa tcgtagacag ccttcagctg gaactcgttg 1697641 acattgaatt tgtcaaagag ggccaaagct ggttccttcg cgtgtttatt gattccgatg 1697701 acggtgtgga tattgaggaa tgtgccaaag taagcgaagc tttaagcgaa aagcttgatg 1697761 aggcagaccc aatcagccaa aattactttc ttgaagtctc atctccagga gctgagcgtc 1697821 cgctaaagaa aaaagccgat ttcgaaaaat cactaggaaa aaacgtatac attaagacgt 1697881 atgagcctat tgacggcgta aaagtgtttg aaggtgaact ggctgaattt gatggacaaa 1697941 cagtgacagt tgagatcacg atcaaaacaa gaaagaaacg gatcaatatt ccgtatgaaa 1698001 agatagctaa tgcaagatta gctgttacat tctaatgaat acaaatgttt taagggggga 1698061 gaccgttaaa tgagcagtga attattagat gctctcacga ttcttgaaaa agaaaaaggc 1698121 atcagtaaag aaattatcat cgaagcaatc gaagctgcgt taatttctgc ttataagcgg 1698181 aattttaatc aagcgcaaaa tgtacgggtg gatctaaacc gtgaaactgg ctccatccgt 1698241 gtatttgcaa gaaaagatgt cgttgacgaa gtatacgacc agagattaga aatctcaatt 1698301 gaagaggcac agggcatcca tccggaatat atggtcggcg atgtcgtcga aatcgaagtt 1698361 acacctaagg atttcgggcg catagctgct caaacagcga agcaggtcgt cacacagcgt 1698421 gtgcgcgaag ctgagcgcgg tgtgatttat tctgaattta tcgaccgtga agaagacatc 1698481 atgacaggga tcgtccagcg tctggacaat aaatttatct acgtgtcttt aggcaaaata 1698541 gaagccttgc tgccggttaa tgagcaaatg ccgaatgaaa gctacaagcc ccatgaccgc 1698601 attaaggtat atatcacaaa agtagaaaaa acaacgaagg gtccgcagat ttatgtgtca 1698661 agaacacatc caggcctgtt aaagcgtttg tttgaaattg aagtgcctga aatttatgat 1698721 ggaactgtcg agctaaaatc tgttgccaga gaagccggcg accgttcgaa aatttctgtt 1698781 cgcacagatg atcctgacgt tgatcctgtc ggttcatgcg tagggcctaa aggccagcgt 1698841 gtgcaagcaa tcgtcaatga attaaaaggt gaaaaaattg acattgtcaa ctggtccagt 1698901 gatcctgtag aatttgtcgc gaatgcgctc agcccttcca aagtgcttga tgtcattgtt 1698961 aatgaagaag aaaaagcgac aactgttatt gttcctgatt accagctgtc tctggcaatt 1699021 ggaaaaagag gacaaaacgc acgcttagct gctaaactga caggctggaa gattgatatt 1699081 aagagcgaaa cggacgcaag agaacttgga atctatccga gagaacttga agaagatgat 1699141 gagccgctct ttacggagcc tgaaactgct gaatcggatg aataagaggt gactttaggt 1699201 gaataaacac aaaaagatcc cattacgcaa atgtgtagtg actggtgaaa tgaagcctaa 1699261 aaaggaactg atccgagttg tacggtcgaa agaaggcgaa atctcagtag acccgaccgg 1699321 aaaaaagaat gggcggggtg cttatttaac gctggataaa gagtgcatct tagcagcaaa 1699381 aaagaaaaac actttgcaaa atcaatttca atcacaaatc gatgaccaga ttttcgatga 1699441 attgctggaa ctggcggaaa aggtgaaaaa ataaaatgtc tggaatggaa tggtttccct 1699501 tgctgggtct ggccaatcga gctcgtaagg tcgtgtcagg cgaagacttg gtaataaaag 1699561 aaatcaggaa tgcgcgtgca aagcttgtcc tgcttacaga ggatgcatca tctaacacag 1699621 caaaaaaagt aactgacaag tgcaattatt ataaagtccc ttataaaaaa gtcgagagtc 1699681 gcgcggttct tggacgctct atcggtaaag aagcccgtgt cgttgtcgcc gtcactgacc 1699741 aaggttttgc gaataagctg atcagcttgc tcgattaata tttttggggg tgaacgaatg 1699801 gctaaaatga gagtatacga atatgcaaaa gcgttaaatg tttcaagtaa ggaaattttg 1699861 accgcactga agaacatgga tttagaagtg aataatcaca tggccatgct tgaagaaaag 1699921 gccattaaaa agctagatgc caaatataaa aaaggcggcg cagctgctaa atctcaaaag 1699981 ccagcagaaa cgaacaaaaa caaacagcca caaggggtta atcagcaatc agctggaaat 1700041 caaccaaata aaattcgaga cggaaagaag aatgacgtgc agaataatca atttaacaaa 1700101 aacaagaaga ataacaacaa caaaaaaaat aaacgcaaca acaacaataa taaaaaccaa 1700161 catcagcaaa agcctgtaaa gccgaaaaaa gagcttcctg agaaaattac attctctggc 1700221 actttaacag ttggcgcact tgctgaagag cttggcaaag agccttcaga actcattaaa 1700281 aagctgatgc ttcttggcgt aatggcaacc attaaccaag agcttgataa agacacaatc 1700341 gaactcattg catcagaata tggtgttgaa acagaagagg tcattgtgct tgaagaaaca 1700401 gagctggaaa aatacgaaga gcctgataat gaagaggatc ttgaaattcg tcctcctgtc 1700461 gtgacaatca tgggccacgt tgaccatggg aaaacaacgc ttcttgacag catccgtaaa 1700521 acaaaggttg ttgaagggga agcaggcgga atcactcagc atatcggcgc ttatcaaatt 1700581 gaagagaacg gcaagaaaat cacgttcttg gatacaccgg gccacgccgc atttacaaca 1700641 atgcgcgcac gcggtgcaga agtaactgat attacgattc ttgtcgtagc tgccgatgac 1700701 ggtgtcatgc cgcaaacagt tgaagcgatt aaccatgcaa aagcagcaga ggttccaatc 1700761 atcgttgctg tgaataaaat agataaagaa tccgcaaacc ctgaccgtgt aatgcaagaa 1700821 ctgacggaat acggacttgt ccctgaagct tggggcggag aaaccatttt tgtgccgctt 1700881 tccgctttaa ctggaaaagg cattgatgag ctcgttgaaa tgattttgct tgtcagtgag 1700941 gtagaggaac tgaaagcgaa tccgaatcgt caggcaaaag gaacggttat tgaagctgaa 1701001 ctcgataaag gcagagggtc agtcgcgacg ttgctcgtac agactggaac actgcatgtc 1701061 ggtgatccga tcgtagtcgg caatacattt ggccgtgtcc gtgcaatggt caacgacatt 1701121 ggccgccgtg tgaaaactgc cggcccgtca actccggttg aaattaccgg tttgaatgat 1701181 gtccctcaag cgggagacca attccttgtc tttaaggatg aaaaaacagc tcgttctgtc 1701241 ggtgaagccc gtgcttcgaa acagcttgaa gagcagcgca gcgataaagc gaagctcagt 1701301 cttgatgatt tatttgagca aattaagcaa ggtgatgtaa aagacatcaa cctcatcgta 1701361 aaagctgacg ttcaaggatc tgctgaagct ttaacggctg cacttcaaaa aattgaagta 1701421 gaaggcgtta aagtgaaaat catccataca ggcgttggtg cgattactga atcagacatt 1701481 atcttggcat ctgcttccaa tgcaattgtt atcgggttta atgtgagacc ggacggaaat 1701541 gctaagagta cggctgaagc tgaaaatgta gatattcgac ttcaccgtat catttacaaa 1701601 gtaatcgacg agattgaagc tgccatgaaa ggtatgcttg atcctgaata tgaagaaaaa 1701661 gtaattggtc aagtagaagt acgccaaaca ttcaaagtat ctaaaatcgg tacaattgcc 1701721 ggcggatatg ttactgaagg aaccattacg cgcgacagcg gcctccgttt aattcgtgac 1701781 ggcgtcgtca tctttgaagg cgaagtagat gttctgaaac gctttaaaga cgatgtgaaa 1701841 gaagtttcac aaggctatga atgtggtatt acaattaaga aatacaatga cattcgtgaa 1701901 ggtgacatcc ttgaagcgtt tgtcatgcaa gaaattgaaa gaacgtgatc ggatttgcgg 1701961 agtgtgaatg catcatttat gatgcaggat cgctaaaaga aaagcgtgcc gttctgaagc 1702021 ggattttaac cagggttcaa aacaagttca atgtttcgat ttcggagatt ggctatcagg 1702081 acacctggca aagaaccagc ttcggaatcg ccgctgtttc ttcctctcgc gttcaaacag 1702141 aaaaagaact gcagcgcgtc ctagcgttta tcgattcttt tcctgaaatt gaacggacga 1702201 tcactaggac agagtggttt taacttagag gtgattgaat tgagtatgag agcaaaccgt 1702261 gtcggcgagc aaatgaaaaa agaactcggt gatattatca gccgcaagct gaaagacccg 1702321 agaattggtt ttctgacagt aacggatgta cgtgtatcag gtgatttgca aattgcaaag 1702381 gtgtatatct cggttctcgg tgacgagaaa aaacgggaag aagcgctgaa agggctggca 1702441 aaagcgaaag gatttatccg atccgaaatc ggcagccgca tcagacttcg aaaaacgcct 1702501 gaaattgaat ttgagttcga tgaatcaatc gattacggga atcggatcga aacactgatt 1702561 cacgaattac attcagagaa accatctgaa taaaaaaaga gaggataggc gtatatcgtc 1702621 tgtcctcttt cttcgtttat aagaaaaaaa ctcaaaagaa ggagtgaaag gcaaatggtt 1702681 aacggagttc tccttttaca taaacctgtt ggcatgacat cgcacgactg tgtcatgaag 1702741 atccgaaagc tgttaaaaac aaaaaaagta ggacatacag gaacgctcga tccggaagta 1702801 tcaggcgtgc ttccgatttg tgtaggaaga gcgacaaaaa tagtcgaata cttaactgaa 1702861 aaatctaaaa cgtatgatgc agaaataaca ttgggctttt caaccacaac agaggatcaa 1702921 accggagaaa cggtggaaac aaagcctgtc aatcacgaca ttgataaagc ggatgtagaa 1702981 aaggttttaa acagtttaaa ggggaaacaa gaacaaattc cgcccatgta ttccgctgta 1703041 aaagtaaacg gcaaaaaatt atacgaatac gcaagagcag ggattgaagt agaacgtccg 1703101 aaacgtatga taaccattga agacattgcc ctgacaacag agattaaaca tcatggagaa 1703161 accgcaagct tccggtttac agtgacttgc tccaaaggga cctatgtaag gacgctggcg 1703221 gtcatgatcg gagaaaagct cggatatccg gcccatatgt ctcatttaat ccgtacggca 1703281 tccggagatt tttctctcga cgaatgcttt acttttgatg aactcgaagc acaggcccaa 1703341 tccggaaccg tggaagagca tacagttcct attgaacgtg cgctcaatca tttgccgaaa 1703401 tggatcataa gtgatacatt agctaagaaa gtagaaaatg gggctttgct tgagacgccc 1703461 gagcagtttt ctgaaatgac aagtggagac cgtattgccg tctttactga atccggaacc 1703521 tgcttggcga tctatttccc tcatcctgca aaaaaagggc tgttaaagcc ggcaaaagta 1703581 ttgatgcaaa aaagcgaaca atagaaaaaa ggtgaccgtt ctgtgaagac gatacatatt 1703641 acacatcctc atcatttaat aaaagaggag caggcaaaat cagtgatggc gttaggttat 1703701 tttgacggcg ttcatctcgg gcatcaaaag gtaatcggca cagcgaagca aatagccgaa 1703761 gaaaaaggtc tgacattagc tgtgatgacc tttcatcccc atccttctca cgtgttgggc 1703821 agagataagg aaccaaagga tctgattacg cctcttgaag acaaaataaa ccaaattgaa 1703881 caattaggca cagaagttct gtatgtcgtt aaatttaatg aagtgtttgc ttctctttct 1703941 cctaagcagt ttatagacca gtatattatc ggccttaatg tgcagcacgc agtggcaggc 1704001 tttgacttta cgtacggcaa atacggcaag ggaacaatga agaccatgcc ggatgattta 1704061 gacggaaaag ctgggtgcac aatggtagaa aaattaacgg agcaggataa aaaaatcagt 1704121 tcttcgtata tccgtaccgc gcttcaaaac ggagatgttg aattggcgaa tgtcttgctt 1704181 ggacaacctt attttattaa aggaattgtc attcatggtg ataaaagagg gcggaccatc 1704241 gggtttccga cagcgaatgt cggtttaaat aacagctata tcgttccgcc cacaggtgta 1704301 tatgccgtaa aagcggaagt gaacggcgaa gtttacaatg gcgtttgcaa tattggctat 1704361 aagccaacgt tttatgaaaa gcgccctgaa cagccttcca tcgaggtcaa tctgtttgat 1704421 ttcaatcaag aggtatatgg agccgctata aaaatcgaat ggtacaaacg gattcggagc 1704481 gagcggaaat tcaatggcat caaagaatta actgagcaaa ttgagaaaga taagcaggaa 1704541 gccatccgtt atttcagcaa tttgcggaaa taacttgcaa cgcacgcaaa ttttattcta 1704601 aaatatttgc atataggcac gatttttagt atgatagttt tcgtagtctt aaaaccattg 1704661 cttggcaatc cgaagtcacc gacggttgct aggtaactgg ggctaaatat gatttggagg 1704721 tgaaacagga tggcaattac tcaagagcgt aaaaaccaac tcatcaatga gttcaaaaca 1704781 cacgaatctg atactggatc tccagaagtt cagatcgcta tcctaactga ctcaattaac 1704841 aacttgaacg agcatttacg tactcacaag aaagaccacc actcacgtcg cggtcttctt 1704901 aaaatggtag gtaagcgtcg taatcttctt acgtatctgc gtaataaaga cgtaactcgt 1704961 taccgtgagt taattaacaa actaggctta cgtcgataat cgtaaaaagc gggaggattc 1705021 ccgctttttt atcgtattaa agcgaaattt cttataacaa atcattgaaa tccttttaca 1705081 tactactttg acattgatat gttcaattca tttcgttcat aataggagta attgattatt 1705141 tcacacaacg aagagaggag ttcgtaattg tatgggacaa gaaaaacatg tctttaccat 1705201 agattgggcc ggaagaacgc ttaccgttga aaccggccag cttgccaaac aggcaaatgg 1705261 tgctgtgatg atccgctacg gtgatacagc agtacttagt acagcaaccg cttcaaaaga 1705321 acctaaaccg cttgatttct tccctcttac tgtaaactat gaagaaagat tatatgcggt 1705381 agggaaaatt ccgggcggat ttattaaaag agaaggacgt ccaagtgaaa aagcggttct 1705441 tgccagccgt ttaattgacc gtccgatccg tcctttgttt gccgatggat tccgtaatga 1705501 agttcaagtc atcagcattg tcatgagtgt tgaccaaaac tgctcttcag aaatggctgc 1705561 catgttcggt tcatctcttg cactttctgt atcggatatt ccgtttgaag gaccgattgc 1705621 aggggttact gtcggacgca ttgatgatca atttatcatt aacccgacag tcgatcagct 1705681 tgaaaaaagc gatatcaatc ttgtcgttgc cggcacgaaa gatgcgatta acatggtaga 1705741 agcgggagcg gacgaagttc ctgaggaaat catgcttgag gccattatgt tcggccatga 1705801 agagattaaa cgcctgattg cattccaaga agaaattgtt gcagcagtcg gcaaagagaa 1705861 atctgaaatt aagctctttg aaattgatga agagcttaat gaaaaagtaa aagctttggc 1705921 agaagaggat ctgctgaaag ccatccaagt tcatgaaaag catgcccgtg aagatgccat 1705981 taacgaagtg aagaacgcag ttgtggcaaa attcgaggat gaagaacatg atgaagacac 1706041 aatcaagcaa gtgaagcaga ttttatccaa gcttgtgaaa aatgaagttc gccgcctgat 1706101 tactgaagag aaagtaagac cggacggccg cggtgtcgat caaatccgtc cgctctcttc 1706161 agaggttggc ctcttgccaa gaacgcacgg ttcaggtcta tttacaaggg gacaaactca 1706221 ggccctcagc gtatgtacgc taggtgctct gggagatgtg caaatccttg acggcttagg 1706281 tgtcgaagag tcgaaacggt ttatgcatca ttacaacttc ccgcaattca gcgttgggga 1706341 aacaggaccg atgcgcggac cgggacgtcg tgaaatcgga cacggagcac tgggtgagcg 1706401 tgcgcttgag ccagttattc cgtctgaaaa agacttccct tatactgtcc gtcttgtttc 1706461 agaagtgctt gaatcaaacg gttctacatc tcaagcaagc atttgcgcaa gcacacttgc 1706521 aatgatggat gccggtgtac cgattaaagc gccagttgct ggtattgcga tgggtcttgt 1706581 caaatcaggc gaacattaca ctgtcttgac tgacatccaa ggcatggaag acgcgctcgg 1706641 agatatggac tttaaagtag cgggaactga aaaaggcgta acggccctgc aaatggacat 1706701 taaaattgaa ggcctttcca gagagattct tgaagaagcg cttcagcagg cgaaaaaggg 1706761 cagaatggaa atcctcaaca gcatgcttgc aacattaagc gaatcaagaa aagagctttc 1706821 tcgatatgcg cctaagatct taacaatgac cattaatcct gataaaatcc gcgatgtcat 1706881 cggaccaagc gggaaacaaa tcaataagat catcgaagaa accggtgtta aaattgatat 1706941 tgagcaggac ggcacaatct ttatttcctc tacagatgaa agcggcaacc aaaaagcgaa 1707001 aaaaatcatc gaagaccttg tgagagaggt tgaagtcggc caactttacc taggtaaagt 1707061 gaaacggatt gaaaaattcg gggctttcgt tgaaattttc agcggaaaag acggtttggt 1707121 gcacatttca gagcttgcgc ttgaacgcgt agggaaagtt gaagatgttg tgaaaatcgg 1707181 agacgagatt cttgtcaaag tcactgaaat tgataaacaa ggacgagtga atttatcccg 1707241 caaagcggtg ctccgtgaag agaaagaaaa agaagaacaa caatcttaaa tgaaaacata 1707301 aaaggagcct gggagacccg gcttctttat tttgaagctt ttcaaaagca ggcgggttct 1707361 accttgtcct tctccttcat aatgtgaggt gaggggggga cagaacatgt acaaaaaatt 1707421 tgtaccgttt gccgtttttt tatttctttt ttttgtctca tttgagatga tggaaaatcc 1707481 gcatgcactt gattatatag gggcaatgaa aaaagatacg gtgactgtca cggcgtcaaa 1707541 agacccgtta tatgaagaat tgcttcaaaa agcgccggag tacgaagtta agccccagaa 1707601 tgcaagaatt gataaagtgt ggaaaagcat tccaggctac aatggattaa aggtcaatat 1707661 tgaacaatca tataaaaaaa tgaaacagca tggtaagttt cgggaaaaag atttggtgta 1707721 cagtcaagta aaaccaagtg ttcatcttga gtcacttcag cctgagccta tttataaagg 1707781 aaatcctgac aaaccgatgg tggctttttt aatcaatgtg gcatggggaa atgagtattt 1707841 ggaaaaaatg cttcctattc tgcaaaagca ccaggttaaa gctacgttct ttttagaagg 1707901 caattgggtg agaaacaatg tacagctcgc taagaagatt gcaaaagacg gacatgaaat 1707961 cggaaatcat tcatacaatc atccggatat gagcaaactg actacaggaa gaatttccga 1708021 gcagctcgac aagactaatg aacaaataga acaaacgatc ggcgttaagc caaagtggtt 1708081 cgctccgcca agcggaagtt tcagaaaagc ggttatcgac attgcagcag agaaacagat 1708141 gggaacagtc atgtggacag ttgatacaat cgattggcaa aagccggctc cgtctgtact 1708201 tcagacgaga gtgttaagca agatacataa tggtgccatg attttaatgc atccgactga 1708261 ccctacggcg gaaagtcttg aagcgctgat tacacagata aaagacaaag gatatgcgct 1708321 tggaacagtc actgaactaa tggatgaaac aagactattg aagtaacaga tgaaggcagc 1708381 ttgtctttga ataggaggaa caaatttgat taaacgatat acgtgtcaaa atggtgtaag 1708441 aattgtgctg gaaaataacc cgacagtccg ttctgttgcg atcggcgtat ggatcggcac 1708501 aggttcgaga catgaaacgc cggagataaa cggaatttct cactttttag agcacatgtt 1708561 ctttaaaggg acgagcacaa aatctgcacg cgagatagca gaatcttttg atcgtattgg 1708621 cggccaggtc aatgcgttta cttcaaagga atatacctgc tactatgcaa aggtgcttga 1708681 cgagcatgcg aattacgcgc tggacgtatt agcagatatg ttctttcatt caacgtttga 1708741 tgaaaacgag ctgaaaaaag agaaaaatgt agtatatgaa gaaattaaaa tgtatgaaga 1708801 tgcgccggac gacattgtac atgatttatt gagcaaagcc acttacggca atcattcttt 1708861 aggctaccca attttaggaa cggaagaaac gcttgcttcc tttaacggtg actctctcag 1708921 acaatacatg catgattatt atacgccgga ccgagtggtg atttcggtag cgggcaatat 1708981 atctgacagt tttatcaaag atgtagaaaa atggttcggg tcatacgagg cgaaaggcaa 1709041 agcgacaggc cttgagaagc ctgagttcca cacggaaaaa ctgacgagaa aaaaagaaac 1709101 agagcaggct catttgtgcc ttggatttaa aggcttagag gttggccatg aacgtattta 1709161 tgatttaatc gtcctcaaca atgtgctcgg aggcagcatg agcagccggc tgttccaaga 1709221 tgtgcgtgaa gataaaggac ttgcttattc tgtttacagc tatcacagct catatgagga 1709281 cagcggaatg ctaacgattt acggcggaac gggtgcaaat cagcttcagc agctgtcgga 1709341 aacaattcaa gaaaccctgg ccacattaaa acgtgacggc attacctcga aagaactgga 1709401 aaacagcaaa gagcaaatga agggaagctt aatgctgagc ttagaaagca caaacagcaa 1709461 aatgagccga aacggaaaaa atgaactgct gctcggcaaa cataaaacat tagatgaaat 1709521 tatcaatgaa ttaaacgccg tgaacttaga gcgtgttaat ggccttgcca gacaattgtt 1709581 taccgaagac tatgcattag cacttatcag cccttccggc aatatgccgt cttaaaaagg 1709641 aaagcctgcc ccataatgga gcaggcattt tttaatccct ttcatcatac atagtacaag 1709701 ggggtgacag acatgcggct cagtgaatta tcgggaaagg aaattgtaga catcaaaaga 1709761 gctgaacggc tcggagtgct cggccagacc gatttggaaa tcaatgaaca ggatggacag 1709821 attacagcac tcctcattcc cacagttaag tggtttggtt tgagaaagca aggtcatgac 1709881 attcgtgtcc catggcacca tattcaaaag atcggttcag atatgattat attagatgta 1709941 cctgaggaaa tgcctcctcg acaagagtaa atagcccaat tgactgtgaa gcgggctcta 1710001 aagaaaacat ctgaaacatc ggctgccgga gccgatgttt ttttatatgg aaaaagcgca 1710061 tcttttatat tcaccggtat ttccttttga tcataagatg aaggggagct taacaactag 1710121 agatccagta tatacaaaga aggtgaacgt ttagaatgtt aaccggattg aaaattgcag 1710181 ttatcggcgg tgacgcaaga cagctcgaaa ttataagaaa gctcactgaa cagcaggctg 1710241 acatctatct tgtcggtttt gaccaattgg atcacggttt taccggggca gtaaaatgca 1710301 atattgatga aattcctttt cagcaaatag acagcatcat tcttccagta tccgcgacaa 1710361 caggagaagg tgtcgtatcg actgtatttt cgaatgaaga agttgtgtta aaacaggacc 1710421 atcttgacag aacgcctgca cattgtgtca ttttctcagg aatttctaac gcctatttag 1710481 aaaacattgc agctcaggca aaaagaaaac ttgttaagct gtttgagcgg gatgacattg 1710541 cgatatacaa ctctattccg acagtagaag gaacgatcat gctggctatt cagcacacgg 1710601 attatacgat acacggatca caggtggccg ttctcggtct ggggcgcacc gggatgacga 1710661 ttgcccgtac atttgccgcg ctcggggcga atgtaaaagt gggggcaaga agttcagcgc 1710721 atctggcacg tatcactgaa atggggctcg ttccttttca taccgatgag ctgaaagagc 1710781 atgtaaaaga tatagatatt tgcattaata ccataccgag tatgatttta aatcaaacgg 1710841 tactttctag catgacacca aaaaccttaa tattggatct ggcctcacgt cccgggggaa 1710901 cggattttaa atatgccgag aaacaaggga ttaaagcact tcttgctccc gggcttccag 1710961 ggattgtcgc tcctaaaaca gctgggcaaa tccttgcaaa cgtcttgagc aagcttttgg 1711021 ctgaaataca agctgaggag gggaaataag gatgtcgtca ttaaaaggaa aaagaatcgg 1711081 gtttgggctg accgggtcgc attgcacata tgaagcggtt ttcccgcaaa ttgaggagtt 1711141 ggtcaacgaa ggagctgaag tccgtccggt tgtcacattt aatgtaaaat ctacaaatac 1711201 ccgatttgga gagggcgcag aatgggttaa aaaaattgaa gacctgactg gatatgaggc 1711261 cattgattcg attgtaaagg cagaacctct tgggccgaag ctgccccttg actgcatggt 1711321 cattgcgcct ttaacaggca attcaatgag caagctggca aatgccatga cggacagccc 1711381 ggtgctgatg gcggcaaaag cgacaatccg gaacaatcgg cctgtcgttc tgggtatctc 1711441 gacaaatgat gctcttggtt taaacggaac aaatttaatg aggctcatgt caacaaaaaa 1711501 tatctttttt attccattcg ggcaagatga tccatttaaa aaaccgaatt caatggtagc 1711561 caaaatggat ctgcttccgc aaacgattga aaaggcactc atgcaccagc agcttcagcc 1711621 gattctagtt gagaattatc agggaaatga ctaaatttac agaaaatctt tcccaaacta 1711681 aaaaattcgg tcatcacccg catattctat ggtaaaataa aacgtaaaat catagtcaaa 1711741 tcaattcaat gaagctgatt ggcggaagga gttttacaga tgggaagagg tttacacgta 1711801 gctgttgtcg gagcgacagg ggctgtggga caacaaatgc ttaaaacact tgaagacaga 1711861 aactttgaaa tggacacact tacattgcta tcttcaaaac gctctgcggg gacaaaagtc 1711921 acgtttaaag gccaagagct gactgttcag gaagcttctc ctgagagctt tgaaggggta 1711981 aatattgctt tgttcagcgc cggcggaagc gtatcacaag cattggcacc agaagctgta 1712041 aaacgcggcg ctattgttat agataatacg agtgcgttcc gcatggatga aaatacaccg 1712101 cttgttgtgc cagaagtgaa tgaggcagac ttgcatgaac acaacggcat tattgccaat 1712161 ccaaactgct ctacaatcca aatggttgcg gcacttgaac cgatccgcaa agcatatggc 1712221 ttaaacaagg tcatcgtatc aacttaccag gcagtatcag gagcgggtaa tgaagctgta 1712281 aaagagcttt acagccaaac acaggcgatt ttaaataaag aagaaataga gcctgagatc 1712341 atgcctgtaa aaggtgacaa aaaacactat caaatcgcct tcaacgcgat tccgcaaatc 1712401 gataaattcc aagataacgg ctatacgttt gaggaaatga aaatgataaa tgaaacgaaa 1712461 aaaatcatgc acatgcctga ccttcaagta gcggctacat gtgtgagact gccaatccaa 1712521 actgggcact cagagtccgt ctacatcgaa atagaccgtg atgacgctac agttgaagat 1712581 attaaaaatc tattgaaaga agctccgggc gtgacacttc aggatgatcc aagccagcag 1712641 ctttatccga tgcctgctga tgctgtcggc aaaaacgatg tgtttgtagg ccgcatccgc 1712701 aaagacttgg acagagcaaa cggttttcat ttatgggttg tttctgataa cctattaaaa 1712761 ggcgcggcat ggaactctgt tcaaattgca gaaagcctga aaaaactaaa cctcgtataa 1712821 aagagagaat tttctaaaga cgaatagaag agagtaaggc gctatcagcc tgctctcttc 1712881 tgttacgtcc gaataatttg gagtgaaaac agtgaagata attgttcaaa agttcggcgg 1712941 aacatcagta aaagatgata aaggccgcaa actggcttta gggcatatta aagaagcaat 1713001 cagtgaagga tataaggttg tcgttgtcgt ttcagcgatg ggccgaaaag gggacccgta 1713061 tgcaacagat tctttgctcg ggctgcttta cggcgatcag tcagcgattt ctcctaggga 1713121 gcaggatttg cttttatctt gcggagagac tatttcctct gtcgtcttta caagcatgct 1713181 gcttgataac ggtgtgaaag cagctgcgct gacaggggct caggctggct ttttaacgaa 1713241 tgatcagcat actaatgcga aaatcattga aatgaaaccg gagcgtttat tcagtgtgct 1713301 cgccaatcat gatgcggtag tcgtcgcagg cttccagggc gcaactgaaa agggtgatac 1713361 aacaacaatc ggcagagggg gcagcgatac gtctgcagcc gcactcggag cagctgttga 1713421 tgcggaatac atcgatattt tcaccgatgt agaaggcgtg atgactgctg acccaagagt 1713481 ggtagaaaat gcaaaaccgc ttcctgttgt gacgtatacg gaaatctgca acctggcgta 1713541 tcagggggcc aaggtcattt ctccgcgtgc tgtggaaatc gcaatgcagg ccaaggttcc 1713601 gatccgcgtc cgttcgactt attcgaatga taaaggcaca ttggtgacat cacatcactc 1713661 ttccaaggtc ggcagtgatg tttttgaaag gctgattacg ggaatcgccc atgtcaaaga 1713721 tgtcacgcag ttcaaagtgc ctgcgaaaat cggccagtat aacgttcaga ctgaagtgtt 1713781 caaggctatg gcaaacgctg gaatcagtgt cgatttcttt aacattacac ctagtgaaat 1713841 cgtctatacg gtagccggaa ataaaacaga aacagctcag cgtattttaa tggatatggg 1713901 ctatgatcca atggtgacga gaaactgcgc gaaggtatcg gcggtcggcg cgggcattat 1713961 gggtgttccc ggtgttacgt ccaaaattgt atcggctctt tcagaaaaag aaattccgat 1714021 ccttcagtcg gctgacagcc atacgacgat atgggtgctc gtccatgaag cggatatggt 1714081 tcctgctgta aacgctttgc atgaagtgtt tgaactttcg aagtaaatgt gattgaatca 1714141 tgatgaggtg aataaaatga atttcggaaa tgtgtctaca gcgatgatta caccctttga 1714201 caataaaggg aacgtagact ttcaaaaact gtctacactg attgattact tgttgaaaaa 1714261 cggaacggat tctttagtag tagcgggaac aactggagaa tctccgaccc tttcaactga 1714321 agaaaaaatt gcgctttttg aatatacggt aaaagaagta aacggacggg tgcccgttat 1714381 cgctggtact gggagcaaca acacgaaaga ttccattaag ctgacaaaaa aagctgagga 1714441 agcgggcgtg gacgctgtta tgcttgttac cccgtattac aataaacctt ctcaagaagg 1714501 aatgtaccag cattttaaag caattgcggc agagacatct cttccggtta tgctctataa 1714561 tgttcctggc cgtacggttg cttctcttgc tcctgaaacg acgatccgtt tggcggcaga 1714621 cattccgaat gtggttgcga ttaaagaagc gagcggagac ctcgaagcga ttacaaaaat 1714681 tattgctgaa acacctgaag acttctatgt ctattcaggg gatgatgctc taacgcttcc 1714741 aattctttca gttggaggta gaggagttgt gtcagtggcg agccatattg caggcactga 1714801 tatgcagcaa atgatcaaaa attatacgaa tgggcaaaca gctaatgcgg cactgattca 1714861 tcagaaactg ctgccgatta tgaaggaact gtttaaagcg cctaatcctg ctccagtcaa 1714921 aacagcgctt cagctgagag gtcttgatgt cggttctgtg cgtctgcctc tagtcccatt 1714981 aactgaggat gaacgtctga gcttaagcag cacgatcagc gaactgtaag aaaatttcat 1715041 acagtgaaac aaacgcggtc attctcacat tcagctgagt ttgaccgttt cttttacata 1715101 ttggttttcc ctaaaccttc tgctttatct tgttttctaa atttactttc agttataata 1715161 ggaacaagtg atgatggacg ggtatgagac taggaggata tagattttga aaaagaaaaa 1715221 tacagaaaac gttagaatta tcgcccttgg cggtgtcgga gagattggga agaaccttta 1715281 tgtcattgaa attgactcag acatatttgt cgttgatgcc ggccttatgc atccagaaaa 1715341 cgaaatgctc ggtattgatg tagtgattcc tgacatatca tatttgattg aacgggctga 1715401 ccgcgtcaag gcaatctttt taacgcacgg gcacgatgaa aatatcggcg gcgtttttta 1715461 cttattaaac aagctgtccg ttccagtgta cggaacaaaa ctgacgcttg cactgttaag 1715521 agagaaatta aaacaatacg gacataaccg aaaaactgat ttaagagaaa ttcactccaa 1715581 atctgtcatt acatttgaat caacaaaggt atcgttcttt agaacgattc acagcattcc 1715641 tgattctgta ggtgtgagct ttaaaacatc acttggatct attgtatgca cgggagactt 1715701 caaatttgac caaacacctg cacttaatca gacgtgcgac attggcgaga tcgccaagat 1715761 cggcaatagc ggcgtgctcg ctctgctttc tgacagtgca aatgcggaac ggccgggtta 1715821 caccccttcg gaagcggctg tcagcggaga aatttcggat gcgctgtata attcacagaa 1715881 ccgggtgatt attgctgttt tcgcatccaa tattaaccgg attcagcaag tcattcatgc 1715941 agcggctcaa aatggcagaa agattgccgt agccggaaaa aatcttcaat ctgtcctgca 1716001 gctggcgaga aagttaggat atattgaagc agatgatgaa ttgtttattt ctgtacagga 1716061 tgtcaaaaaa tatccgaagc gcgaagtggc cattattaca gccggaagcc aaggtgaacc 1716121 attagctgct ttgacaagaa tggcaaacaa agctcacaaa cagctgaaca ttgaagaagg 1716181 ggatacggtg gtcattgcgt caactccgat tcccgggcag gaactcattt actctaaaac 1716241 agtagatctt cttgcgagag ccggtgcaca agtcatcttt gcccaaaagc gtgttcatgt 1716301 atcaggccac ggctcacaag aagagttaaa gctgatgatc aacctgctta aaccaaaata 1716361 tttgattcct gtaaacggcg aatacagaat gcaaaaagct cattcaaaaa tcgctgaaga 1716421 aaccggcatg aagcgcagtg acatcttctt aattgaaaaa ggcgacgtcg ttgaattccg 1716481 cggccaaaac gtaaaaattg gggataaagt tccttacggc aatattttaa ttgatggttt 1716541 aggtgtcggt gatatcggca atatcgtatt gagagaccgc cgcttgcttt cacaggacgg 1716601 aattttaatc gttgtcatta cacttgataa acaaaagaaa catcttgtat caggaccaga 1716661 aattatcact cgcggctttg tttatgtaag agagtctgaa ggtcttatcg tacaggctac 1716721 tgagcttgta cggtccatcg tgacagaagc gactgaaaca tcaaatgtcg aatggtcaac 1716781 gctgaagcag gcaatgcggg atgctttgaa ccaattcctt tatgaaaaaa cgaaacgtaa 1716841 accgatgatc atcccaatta ttatggaagt ataatgactg actaaagacc ggagctgctc 1716901 cggtctttat tttttgtcct tcaagccggg attgaatgaa gtatctttgt tcataataca 1716961 aagagaaact cggaaaggat gaaagcgaga tggatcatcg tatggaaaac acagaagaag 1717021 agcgtcctga aaaaaatgat gcgaaggaca gcattatgaa taaaatacag cagcttggtg 1717081 aaacgacgct tccgcagctg ccccaagata caaatattca ttgtctgacc attatcggac 1717141 aaattgaagg ccatgttcag cttcctccgc aaaacaaaac aacaaaatat gaacatgtca 1717201 tcccgcagat tgtggcaatt gaacaaaatc ccaaaattga aggcttgctg atcatattaa 1717261 atactgtcgg aggagatgtt gaagctggtc ttgccatagc ggaaatgctt gcatctttat 1717321 cgaaaccgac cgtttctatc gtgcttggcg gggggcattc aatcggcgtt ccgattgctg 1717381 tatcctgtga ttacagctat atcgccgaaa cagcaacgat gacgattcat ccagttaggc 1717441 tcaccgggct ggtcatcggg gtgccgcaaa cgtttgaata cctggataag atgcaagaaa 1717501 gagttgttaa atttgtgaca agccattcca atataaccga agagaagttt aaagagctaa 1717561 tgttttcaaa aggaaactta acacgcgata tcggaacaaa tgtagtcggt aaggatgcag 1717621 ttaaatacgg attgatcgat cacgcaggcg gtgtcggaca ggcaatcaat aaactgaatg 1717681 agctcatcga tgaagcaagg aaagaagaag gacggatgat tcaatgattc tttataccgt 1717741 gatgcctcag gaaattgtgt ttgcagaaca gaaccaagag acaagcgcac atgagcaaat 1717801 tgaatataaa ggtgtaccgc ttctagtcga aatgaaaggg aatgaagcgg aagtcattca 1717861 aatcatgagc accaatccaa tgcattttct gcatccggac atttcaccgg gacaaaagct 1717921 gaaattaaac gtataagaat ccaacccttt tttaagggca aaatatgcta taatagggga 1717981 atcctacaga aaaaacgcag cctgtaaacg gctgctttct tcattatgta tgaacttaca 1718041 ttttttaacg cagtaaggtg atgagtgtgg caaagaaaaa acgaaaatca agaaaaaaac 1718101 aggcgaaaca gctcaatata aaatacgagc tcaacggatt gctgtgtata gccatttcaa 1718161 ttatcgcaat cttgcagctg ggggtagtcg ggcaaacgtt tatctatttg ttccgctttt 1718221 ttgctggaga gtggtttatt ttatgcttgt taggtttatt ggtgttagga gtctcactgt 1718281 tttggaagaa aaaaacccca agccttttaa cgagacgaaa ggccgggttg tactgtatta 1718341 tcgcaagcat attgctgctt tctcacgtgc agctatttaa aaatttgacg cacaaagggt 1718401 ctattgagtc tgcaagcgtg gtgcgcaata cgtgggaatt gtttttaatg gacatgaatg 1718461 gcagctctgc ttcacctgat ttaggcggag ggatgatcgg tgcgctgctg tttgcggctt 1718521 cacacttttt gtttgcgtcg actggttctc agatcatggc aattgtcatg attttgatcg 1718581 gaatgatttt agtaacagga cgctcgctgc aagaaacgct aaaaaagtgg atgagcccga 1718641 ttggacgttt tataaaagaa caatggttag catttattga tgacatgaaa tccttcaaat 1718701 caaatatgca gtcatcgaaa aaaacgaaag cgccgagcaa aaaacaaaaa ccggcccgca 1718761 aaaaacagca aatggaaccg gagcctcctg atgaagaggg ggattatgaa acagtatcgc 1718821 ctcttattca ttcagagccg attatctcaa gcttttctga tcgtaatgaa gaggaagagt 1718881 ctccagttat agaaaagcgc gccgaacctg tgtcgaagcc gcttcaggac atccaaccgg 1718941 agacaggtga tcaggaaact gtttctgctc ctcctatgac ctttacagag ctcgaaaata 1719001 aggattacga gatgccgtca ctggatttgc tggcagatcc gaagcatacc ggccagcagg 1719061 ctgataaaaa gaatatttat gaaaatgcga gaaagcttga acgcacattc caaagctttg 1719121 gcgtaaaggc gaaagtcaca caggttcatc tcggaccggc cgtaacaaaa tatgaagtat 1719181 atcctgatgt cggagtgaag gttagcaaaa ttgtcaattt aagcgatgat ttagcgcttg 1719241 cgcttgctgc gaaggatatc aggatcgaag cgcctatacc aggcaaatca gcaatcggaa 1719301 ttgaagttcc aaacgcagaa gtggcaatgg tttcgctgaa agaagtgctg gagtctaaat 1719361 tgaatgacag accggatgcg aagctgttaa ttggactcgg ccgcaatatt tcaggtgaag 1719421 ctgtattggc tgagttaaac aagatgcccc accttttggt cgcaggcgca accggtagcg 1719481 ggaaaagtgt ctgtgtcaac ggcattatta caagtatttt aatgcgggcg aaaccgcatg 1719541 aagtgaaaat gatgatgatc gatcctaaaa tggtagagct aaatgtctac aacgggattc 1719601 cgcatttgct tgctcctgtt gtaaccgatc cgaaaaaagc gtcgcaggct ttgaaaaagg 1719661 ttgtcaatga aatggagcgg cggtacgaat tattttctca tacgggtaca agaaatattg 1719721 aaggatacaa tgattatata aaacgcgcca acaatgaaga aggagcgaaa cagccagagc 1719781 tgccttatat tgttgtcatt gtggacgagc tagccgatct catgatggtc gcttcatctg 1719841 atgtggaaga ttcgattacg agattgtccc aaatggcgcg ggctgccggc atccatctta 1719901 ttattgcgac acagcggcca tcggtggatg ttatcacagg ggtgatcaaa gcgaacattc 1719961 cgtcacgaat cgcgttcagc gtatcttcac agacggattc aaggaccatt cttgacatgg 1720021 gtggcgctga gaagcttctt ggccgcggcg atatgctgtt tttacctgta ggggctaaca 1720081 aacctgtccg tgtgcaggga gcatttttgt cggatgacga agtggagaag gtcgtcgacc 1720141 atgtgattac tcagcagaaa gcgcaatatc aagaagaaat gattcctgag gagacgacgg 1720201 aaactcattc cgaggttact gatgaacttt atgatgaagc tgttgaatta atcgtcggca 1720261 tgcagacggc atctgtttca atgctgcaaa gaagattcag aattggctat acgagagcgg 1720321 cgcgcctgat tgacgcaatg gaggaacgcg gtgttgtcgg accgtatgaa ggcagcaaac 1720381 ctagggaagt attattatca aaagagaaat atgatgagct ctcttcttaa tgaagggagt 1720441 tccgctttct atagttgtca ataatgatat tatgtaaact gatcaccttt ctatttattt 1720501 tttcgacaaa acatgatata gttgtcccaa ttgttcaata atttttatcg aaagtggttt 1720561 acggagggga aacatgtcta caaaagctga taatcggcac ttgtatttga aagtaattga 1720621 acgaattaaa gaggatataa aaaatgggat ctacactgag aaggaaaagc tgccttctga 1720681 atttgagctt tccaaaaagc ttggtgtcag cagagcgacg ctaagagaag ccttgcggat 1720741 actggaagaa gagcatgtga ttatcagaag gcatggtgta ggcacttttg tccattctaa 1720801 gccgttattt ctttcgggta ttgaacagct gaacagtgta accaagatga tagaacaggc 1720861 gaatatgacc cctggcacga tttttctatc atcacaagtg cttatgccgt ctgaagatga 1720921 tacgaagaga tttcacttgg cagaagggca agaacttttt taccttgaac gagtcaggac 1720981 agctgacgga cagccgattg tgtattgtat agacaaaatt ccgatgaata ttttgccgaa 1721041 ttctttttct catcagcaag aatctatgtt tgacctgcta gagaaaaatt caggctccgt 1721101 aatcagctat gcagtaactg atatagaacc gatcggctat cacgatacca tttctccagt 1721161 gcttgaatgc gatccggaaa cagctctttt gctgttaaaa caaacccatt acgatcagca 1721221 cgataaaccg gtgctttatt ctttaaatta ttttagagcg gataaattca gatttcatgt 1721281 tttgcgtaaa cgattctaaa aacggacgcc tgtatgtgtc tgttttttta tttgcactga 1721341 ttcatgtttc tttgtacata ctttcattcc ggttaacgca atatataagg gatgacaaga 1721401 aagtgaatgg gtgaaaatgt tgagagagaa aaatggaatg aaaaatatta ttgcattgtc 1721461 ttctgtcccg cttgtgatga cactcgggaa ctccatgctg attcctgttc ttccgatgat 1721521 ggagaaaaag ctgtctgtga cttcatttca agtatcttta atcattactg tatattcagt 1721581 agtagcaatt atttgcattc cgattgccgg atatttgtcg gatcgtttcg ggagaaaaaa 1721641 aatattgctt ccatgcctcc tcattgcagg attgggggga gccgtagctg cttttgcctc 1721701 gacctatatg aaaaatcctt atgctatgat cttggcgggg cgggttcttc aaggcattgg 1721761 ttctgcaggt gccgctccga ttgtcatgcc gtttatcggc gacctgttta aaggagacga 1721821 tgaaaaggtc agcgcgggtc ttggcgatat tgaaaccgcc aacacgtcag ggaaggtact 1721881 gagtcccata cttggagcct tactggcttc ttggtattgg tttgtaccgt tttggtttat 1721941 tccgtttttc tgtttgatca gctttttgct cgtattgttt ttggtggcca agcctgaaga 1722001 agatgaagat gcgcctgctg tttctgagtt tattaagagt gtgaagaaaa tttttaaaca 1722061 ggatggtcgc tggctttata cggtcttcat tatcgggtgt gtcattatgt ttttgttatt 1722121 tggcgtatta ttttatttat cagatacgct ggagaacaag tatgctattg acggagtagc 1722181 taaaggcgga ttactggcaa tcccactttt gtttttgtca accagttctt ttatagctgg 1722241 caaaaagatc ggtaaagata aaggccgaat gaaattttgc gttgttacag gaatgattct 1722301 gttaaccctt tcgtttattg ccttgtggtg gaaccacagt ttttattttt tatttgtctt 1722361 tttaagcttt ggcgggattg ggattggaat ggctcttcct gctttagatg cattgataac 1722421 cgaagggatt gaaagtgaac aatgcggaac catttcctcc ttttacaata gcatgcgctt 1722481 tataggagta gctctcggtc cacctgtttt tgctgcatta atgtctaatg caaactggat 1722541 tattttcata ctctcggcgt tttgcagcat cgtttcttta tttttagtgc tctttactgt 1722601 agatgctaaa aaaagtgaag aagaaaaaaa cttagggacg gtctagccag ccgtcttttt 1722661 ttgcgctttc ttgcacagtt tacaactgta cctatacagc atgcggaggt tattgtttcc 1722721 ttataaatcc tacagttgct ataattacat gaaagagtgt ttctgcggat gctgaaaatt 1722781 ggtcataata catactaatt aagaaatgaa cgaaggaggt tccatatgtc atatgttaat 1722841 gaactcaaat caaagcacgg cggtttaacc gcacacattg taaaaacaga aaaattcaaa 1722901 accgtctcgc ttatttttaa gatgcttgcg ccgctgacaa aggatcaagt caccaaaaga 1722961 gcgcttctcc cgcatgtgct tcttcgcgga acgaaaagcc atccgaaaac cgcaggattg 1723021 cgttcatact tggatgagct gtacggcacg tcagtatcgg ctgatcttac gaaaaaagga 1723081 gagcggcatg tcattacgtt caggcttgaa atcccgaatg aaaaatattt aaaagaccaa 1723141 acgccgcttc tcgagaaagg gctccagctt ctcgcagaac tcgtcttttc acctgctttg 1723201 gagggagacg cttttcagtc acaatatgtg gctcaagaaa aacggacgct taagcaaaga 1723261 atccaagccg tctatgatga taaaatgcgt tattcgaatt taaggctgat acaggaaatg 1723321 tgcaaaaatg atccttacgc gcttcatgtc aatggtgaaa tcgacgatgt cgatgacatt 1723381 acggcagagc aattatacga aacataccaa agcgctatcc aaaaagacca gcttgatcta 1723441 tatgttgttg gcgacgtgga cagtaaccag gtacaatcgg caattgataa gtatttcaaa 1723501 acagaagagc gcactcttgg catgattgaa aacaatcacg ctgatgaaaa agttcagcca 1723561 aaagaagtaa ttgatgaaga ggatgtcaag caaggaaaac tgaatatcgg ctaccgcacc 1723621 agcatcactt atacagatca ggattatcct gctttacaag tgtttaacgg attgttcggc 1723681 ggattctctc attctaaact tttcattaat gttcgggaaa aagccagtct tgcttactac 1723741 gcggcttcgc gtatagaaag ttttaaaggc ttgttaatgg tgatgtcagg cattgaagtg 1723801 aaaaattttg aacaggcggt ttcgattatt gctgagcaat tccaggcaat gaaaaatggc 1723861 gatttcagtg agcaggatat agcacagaca aaggccgtta ttcgaaatca agtgctggaa 1723921 acgattgata cagcatacgg tttatctgag tttttatatc agcaggccgc tgctcaagtc 1723981 gagattccta tcgaagactt tcttgccaat attgagaatg tcacaaaaga ggatatcatt 1724041 aaagccggcg aaaagattca gcttgatacg acttatttct taaaagggac ggagggtgca 1724101 tcttgatcaa accaatcgaa tatgaacagc ttcaggagac gctgtatcat gaaaaaatgt 1724161 ccaacggcct tgatgtttac gttttgccga aaaaaggctt caacaagaca tatgcggtct 1724221 ttacaacaaa gtacggctcg atagataacc ggtttgtccc tttaggtaaa aacgagatgg 1724281 ttcacgtgcc ggacgggatt gctcactttc ttgagcacaa gctgtttgag aaagcggacg 1724341 gagacgtttt tcaagatttc agcaaacagg gggcttctgc caatgcgttt acgtcattta 1724401 caagaacggc ttaccttttc tcaagcacat caaatgttga acgcaattta gagacgctta 1724461 tcgatttcgt acaggaccca tattttactg aaaaaacggt tgaaaaggaa aaagggatta 1724521 tcgggcagga gattaatatg tacgacgata accctgattg gaggctttac ttcggggtca 1724581 ttgaaaacat gtacaaagag catcctgtca gaattgacat agcgggaaca gtggaaagca 1724641 tttcacatat tacaaaagac cttctttatg aatgctatga aacgttttat cacccgagta 1724701 acatgctcct tttcattgtc ggccctgtag atcctgaagc gattatttct caggtaagag 1724761 aaaaccaggg gaaaaagccg tatactgatc agccggagat caaacgagaa gaagtgaaag 1724821 agcaagaagc ggttttccga aaagaaaaag agatcaaaat gaacgtgcag ggaccgaaat 1724881 gccttgttgg gctgaaatcc aaaaatccgt ttaaattagg caaagagctc ttaaagcatg 1724941 aactttcaat gaacttattg cttgaagctc tttttggcaa aagctctgcc cagtatgaat 1725001 cactttatga aaaaggatat attgacgaaa cgttcagctt tgattttact gctgaatatg 1725061 ggttcggttt tgcggcgatc ggcggagata cgcctgagcc tgatcaattg gctgaagaca 1725121 tttcaagcat gcttttgcgc gccggtgaac tgattactgc tgaaaagatt gaacttgcca 1725181 gaaagaaaaa gatcggcaca ttcttaaaag cgctgaattc ccctgaatac atcgccaatc 1725241 aatttacccg ttatgcgttc ttggatatga gcctgtttga tgttgtaacg gtactcgagc 1725301 agattaccct cgaggatgtc cagaacgtaa tacaagagga aatcgctgca gacagactga 1725361 ctgtctgcaa ggttgttcct aaatcataaa caaaacatcc ctccagtgtg aggggtgttt 1725421 ttctgcggaa agaaggaaag aggatgaaca aaacagcact aatcaccgga gcaagcggcg 1725481 gcattggcaa aagcatcagc gaaacccttg cagctagagg atacaatctg ctgctgcatt 1725541 acaatacaaa tcaaaacgcg gcagcggagc ttgctgaaaa actaagtcag atgtttggcg 1725601 taaatgcgga gatattacaa gctgacctgt ccgcgcaaga tggagcagat aagctgacaa 1725661 gttcaattgt tcagccgatt gatgcgattg ttttaaacag cggacgaagc cattttgggc 1725721 tgattacgga tgtagataac gcaacggtcc aggaaatggt tcagcttcat gtggcgagtc 1725781 cgtatatgct gacgagaaac cttctgccag gcatgattcg gaataaatcg ggagcgattg 1725841 tggctgtcag ctcgatttgg ggagagactg gagcatcctg tgaagtgttg tacagcatgg 1725901 caaaaggagc tcagcattca tttgtaaaag gattggctaa ggagctggcg ccaagcggaa 1725961 tcagagtaaa cgccgtagcg ccgggtgcag ttgatacaaa tatgatgaat caatttaccc 1726021 cggctgaaaa agaagagatc gctgatgaga ttccgatcgg ccggctggcc cggccgcaag 1726081 aaattgcgga tgcaacagct tttctcctgt ctgaaaaagc gtcatatatc accggccaaa 1726141 ttctgtcggt gaatggcggc tggcactgct gatccgaaaa tattcggtgt atagtttctt 1726201 ttgcgaagga cacaataatc ttgtaacttc acatgaaatg gaggaaacaa gcatgtcagt 1726261 attagaaaac tgggatagct ggaaaaactt ccttggcgac cgtctgaact atgcgcaaga 1726321 taaaggtatg agccaggata cgattacaga tcttgcgaca gaaatcggca gctacttggc 1726381 taatgaagtg gaatctaaga acgagcagga aaaagtgctg gcagatcttt ggagtgtagc 1726441 atcaaaagat gaacagcacg ccattgccaa tatgatggtt aagcttgttg aaaataacag 1726501 cactcactag gaagagaggg gatttttcct ctctttttta tgttttcctc atcacagcaa 1726561 cattcttctt tctaattaga gaaaaatgct ttatgataaa ggaaggtaaa attttgccac 1726621 aatgaagggg gtatatcatt tggcaaagct cgaatggtat tttgaatatg aaattcaagt 1726681 gaaccgcccc ggactgctcg gggatatttc atctcttctt gggatgcttt ctatcaacat 1726741 cgtaacgata aacggcgtcg atctttccag aaggggaatg ctcctcaggt gccgccatat 1726801 agatcaaatt aaacgattag aatcaatctt aaaaacgatg gaaacaatta aagtaacgaa 1726861 gcttagagaa ccgaggcttc gcgaccgtct tgccgtacgc cacggccgtt atattcaacg 1726921 ggatgccgat gacaagaaaa cgttccgctt tgaacgggac gagcttggct tattagtcga 1726981 ttttatggcc gaattgttca aaaaagaagg ccataaatta atcggaatca gaggtatgcc 1727041 gcgtgtcggg aaaacggaat cgattgtagc ctctagtgtg tgcgagcaaa aggtggctgt 1727101 ttgtgtcatc aaccttgctg aagcagacga taagaagcca gctgattgcc gatgaataca 1727161 gcactgaaaa tgtctttatc gttgacggaa ttgtgtcaac acgaagaggg tcagaacgcc 1727221 atctccagct ggtccgagaa atcatgcggc tgcctgcaac aaaagtggtg gagcatccgg 1727281 acatattcgt tcaaaataca gagtatacac tagatgactt tgattatatt attgaactga 1727341 gaaatgaccc tgatgaggtt attacatatg aacatgccga ggaaccccaa atgtttgatc 1727401 aatccgggtt ttcaagcttt gatttttaaa attggaaggt gtttgttgtg actgaactag 1727461 gaatccggct caaagaagcc agagaggaaa aagcaatgtc attggatgat ctccaagcgg 1727521 caacaaagat tcaaaaaagg tatttaaccg ccttggagga aggaaactat gacattattc 1727581 cggggaagtt ttatgttcgg gcattcatca agcaatatgc agaagccgtt gggcttgatg 1727641 cggatcagct gtttgaggag cataaaaaag atatccctaa tacgtatcat gatgatgtgt 1727701 ctgaaaagat ctccggcatg aatcttcaaa aggaaatgcc aaagccagca tctaaggcgc 1727761 tggagctgct gccaacaata cttgttattc tcggcgtgat tgtcgtgatt gccattgtgt 1727821 acgcgatcat tcaatttgcc aatcacaaaa acagtgatga tcacaatgcg gcatcagaaa 1727881 aagcaattac gcaaagtgag agcaagtacg aaatccctaa agattcaacg ctgaaagaga 1727941 atcaaaataa cagctctgaa aaagagacag acactaaaaa agaaacgaaa gaaaacgaag 1728001 ataagaaaaa agaaaatgac agtgagaagc tggagattaa agctgctggc actgaaggat 1728061 cgttaacgac ttatgaagtg tccggcgctg ataaaatcga gctggaactg aaggcatcag 1728121 acagctcctg gattagagtg cgcgatgaaa acagcagctc tttaaaagaa ggaacgctga 1728181 aaaaagacga aacctataaa aaagacataa ctgatcagaa acaagttgat atccgcaccg 1728241 gatatgcacc taatctgaaa ataaaaatca acggtaaggt tctttcatat gaacttgatc 1728301 cgaaaaaagt gatggcacaa accataaaga ttgtaaataa aaaggaagaa aagtcatctt 1728361 aattaccaga tgacttttct tcacgtccga gtatgaaatt ggaggggctt tatgtttaac 1728421 ttaccaaata aaatcacact agctagaatc gcattaatcc caatcttcat gattatcatg 1728481 ctggcgccgt ttgactgggg caggctcgaa gttggagacg aatccatccc ggtcgcacat 1728541 ttggcggggg ccattctatt tattattgca tctacaacag actgggtgga cgggtattat 1728601 gcccgaaaat taaatctcgt aacaaacttc gggaaatttc ttgatccgct tgcggacaaa 1728661 ctgctcgtat ccgcagcgtt aattatcctt gttcaatttg atctcgctcc agcttggatg 1728721 gtcattgtga ttatcagcag ggagtttgcc gtgacaggtt taaggcttgt cttagccgga 1728781 acaggagaag tcgtagctgc taacatgctt ggtaaaatca aaacctgggc acagattatt 1728841 gcggtatctg cattgcttct tcataatctt ccatttgaac ttgtgtcatt cccgtttgca 1728901 gacttggcgc tgtgggtagc cgtcttcttt actgtcgtct caggctggga atatttctct 1728961 aaaaattggg aagcgttaaa aacatctaac taagaaagaa ggacttcgtc atggaatttc 1729021 caaaaaaagc agaaataatt gcagtcggtt cagagttgct gcttggtcaa atcgccaata 1729081 caaatgctca atttatcagc aaacagctcg ctgaaatcgg ggtcaacgta ttttatcata 1729141 cagcggtcgg agataacccg gagcggctga agcaggtcat ccgcattgct gaagaacgct 1729201 ctgacttcat tattttttca ggagggcttg gacccacaaa agatgatctg acgaaagaaa 1729261 cgattgcaaa tacgctggga cgtccgcttg tgttaaatga tgaggcattc caatccattg 1729321 aggactattt caaacgaaca aaacgcacga tgtcacctaa taaccgaaaa caggcgcttg 1729381 tgatcgaagg ctctgacgtg ctggcgaatc actttggaat ggccccggga atgctcacag 1729441 agcatgaatc gcgctattat atgcttcttc ctggaccgcc gagcgaattg cgtccaatgt 1729501 ttgaaaacga ggcaaagcct cttctgctga aaaagatggg ttcaaatgaa aaaattgtgt 1729561 caactgttct tcgctttttc ggtatcggtg aatctcagct tgaagccgat ttggaagata 1729621 ttattgatgc acaaaccaat ccgacaattg cgcctttggc ggctgatgga gaggtgacgc 1729681 tgcgtctgac agccaaacac gccgatgaaa aggaaacaga gcgtctgtta aaagaaacag 1729741 aggccgttat cttagagcgt gtcggtgaat ttttctatgg ttacgatgat acttctcttg 1729801 taaaagagct atctatagca tgtaaggaaa aaggcataac aatttctgcg gcagaaagct 1729861 ttaccggagg gctgttttct gaatggctga cggatcatag cggtgcctca aaattatttg 1729921 ccgggggcgt tgtttgctat acaaacgacg tgaagcagaa tgtgcttggt gtcaagaagg 1729981 aaacattaga tcgttttggg gcggtcagca aggagtgcgc atccgaactg gctaagggtg 1730041 ttcaaaaact cactggcagc gatatcggca ttagctttac tggtgtagca ggacctgatg 1730101 ctcaagaagg gcatgagcct gggcatgtgt ttatcggcat ttccgcaaat ggtaaagaag 1730161 aggttcacga gtttcacttt gcgggctcca gaacggggat cagaaaacgc ggcgctaaat 1730221 acggctgcca tttaatctta aagcttttag agcaaaaata atattttcag cacattatcc 1730281 tcctaagaaa acatgatttc tctgatacat tatgatattt tgataggaat cacgccaaga 1730341 aaaaatccga atatgcgttc gcttttttct tggcaaatcc cttcaaacag ggtatagtat 1730401 atgtagtggt aacataaagg aggaaaaaat agaatgagtg atcgtcaggc agccttagat 1730461 atggctctta aacaaataga aaaacagttc ggcaaaggtt ccattatgaa actgggagaa 1730521 aagacagata caagaatttc tactgtacca agcggctccc tcgctcttga tacagcactg 1730581 ggaattggcg gatatcctcg cggacggatt attgaagtat acggtcctga aagctcaggt 1730641 aaaacaactg tggcgcttca tgcgattgct gaagttcagc agcagggcgg acaagccgcg 1730701 tttatcgatg cggagcatgc gttagatccg gtatacgcgc aaaagctcgg tgttaacatc 1730761 gaagagcttt tactgtctca gcctgacaca ggcgagcagg cgcttgaaat tgcggaagca 1730821 ttggttcgaa gcggggcagt tgacattgtc gttgtcgact ctgtagccgc tctcgttccg 1730881 aaagcggaaa ttgaaggcga catgggagat tcgcatgtcg gtttacaagc acgcttaatg 1730941 tctcaagcgc ttcgtaagct ttcaggggcc attaacaaat cgaagacaat cgcgattttc 1731001 attaaccaaa ttcgtgaaaa agtcggtgtt atgttcggga acccggaaac aacacctggc 1731061 ggccgtgcgt tgaaattcta ttcttccgtg cgtcttgaag tgcgccgtgc tgaacagctg 1731121 aaacaaggca acgacgtaat ggggaacaaa acgaaaatca aagtcgtgaa aaacaaggtg 1731181 gctccgccgt tccgtacagc cgaggttgac attatgtacg gagaaggcat ttcaaaagaa 1731241 ggcgaaatca ttgatctagg aactgaactt gatatcgtgc aaaaaagcgg ttcatggtac 1731301 tcttatgaag aagagcgtct tggccaaggc cgtgaaaatg caaaacaatt cctgaaagaa 1731361 aataaagata tcatgctgat gatccaggag caaattcgcg aacattacgg cttggataat 1731421 aacggagtag tgcagcagca agctgaagag acacaagaag aactcgaatt tgaagaataa 1731481 aaataaaata agtttcaaat gatacaaaag gctgagtgaa aaactcagct tttttgtatt 1731541 ttgcaaaaaa atgataaaaa tattgctttt tttgacaact tttttagggc tttattcgtc 1731601 taacaaaacg tgtgcaaaat ggaatttatt ttgggaggaa aaaatgaatg acaagcccaa 1731661 cccgcagaag aactgcgaaa cgcagacgga gaaaactaaa taaaagagga aaactgttgt 1731721 ttggtctttt agcagtgatg gtttgcatta cgatttggaa tgctcttcat cgaaatagtg 1731781 aagaaaacga accatctcaa gaaactgcag cggtttcaaa taccgatcag aaaaaagagg 1731841 tcaaaaagaa aactgccaaa aaatcagagg aacaaatcaa aacagtggat cgaaaccaaa 1731901 aaatcagcaa ttatttaaaa gagatcggtt tcagcggaac agccatgatt gtcagaaatg 1731961 gagaaatcgt aacaaataaa ggttttggct atgctgaccg taaacactac attcaaaata 1732021 atccattgac atctttttat gtcggttcat cacaaaaagc gctgattgca actgctattt 1732081 tgcagcttga ggaaaagggg aaacttcaga caagtgatcc ggtaagcacg tatttacctc 1732141 attttcccaa cggacaaacg attactttga agaatctgct tacacataca tcggggataa 1732201 acggacatat tgaaggaaac ggcgccatta ctccggacga tttaataaaa gatatagaac 1732261 ttcagggaat caaacgtcag ccgggcgtat gggactacaa ggattccaac tattctgttc 1732321 ttgcttatat tattgctgaa gtaagcggtg agccctatga acagtacata aagaatcata 1732381 tttttaaacc tgcgggaatg acgcatgcag gcttttacaa aacatatgaa aaagaacctt 1732441 atcctgccgt cgggtataag atggagggca gcaaaacagt tacaccgtat atacctgatt 1732501 tatcccagct gtatggagcg ggtgatattt atatgagcgc tatagatatg tacaaatttg 1732561 accaagcgct gatagacgga aaactgtatt cgcaaaaaag ctatgaaaag atgtttacgc 1732621 cagggagcag ctccacatac ggcatgggat tttatgttgc tcccggaagc tattcaaacc 1732681 atggtgttat gccgggcttc aatatcttga acagctttag caaatctggg caaaccattg 1732741 ttattttgtt ctcaaacatt caaaataatg ctaaattggg ccaagtgaac aataaaatat 1732801 accagcttct aaatcaagaa tgattggcga tcttcttttg gatgaattgc attcggcacg 1732861 tgaaaagaag actggcctgc aaacgttaag atggcaagct tgacaagtat ttccgacaca 1732921 tttacaatga agttgtaaca tttgtttttt taacatgatt gttaaaccat ttaaacttga 1732981 caagggcgat gaacacactc attccctgtg aaggttctgt atgttgagaa aactagacaa 1733041 tgtacatgcc gacacttttt aagcaacaac caagttcata gcaagaggag gtgaaagtat 1733101 gaccccaatt atgatggttc tcatctccat tttgctgatt ctactcggtt tagttgttgg 1733161 ctactttgtt cgtaaaacca ttgccgaagc gaaaattgcg ggcgcacgcg gtgcagccga 1733221 gcaaattctt gaagatgcga agcgtgatgc tgaagcactg aaaaaagaag ctctgcttga 1733281 agcaaaggat gaaatccaca aacttcgaat agatgctgaa caggaagttc gtgaaagacg 1733341 aaatgagctt caaaaacaag aaaaccgttt actccaaaag gaggaaaacc ttgatcgcaa 1733401 acatgaggga attgataaac gggaagcgat gttggagaag aaagatcatt ctctgaatga 1733461 acgacaacaa catattgaag agatggaaag caaagtggat gagatgattc gtatgcagca 1733521 gtctgagttg gaacgaattt cgagtctgac tcgtgacgaa gcgaaacaaa tcattcttga 1733581 gcgggttgaa aacgagcttt cacatgacat cgccatcatg acaaaagaaa ctgaaaaccg 1733641 tgcgaaagaa gaggcggata agaaagcgaa aaacattctt tcactcgcct tacagcgctg 1733701 cgcagcggac cacgttgccg aaacaacggt atcagttgtc aatcttccaa atgatgagat 1733761 gaaaggacgt atcatcggac gggaagggcg taacattcgt acgcttgaaa cgctgacagg 1733821 aattgacctg attattgatg atacgcctga agctgtcatt ctttccggat ttgatccgat 1733881 cagacgtgag acagccagaa ttgctcttga taaactcgtt caggatggcc gtattcatcc 1733941 ggcacggatt gaagaaatgg ttgaaaaatc tcgccgcgag gtcgatgact atattcgtga 1734001 gatgggtgag caaacgacat ttgaggttgg cgttcatggc ctccacccag atctcatcaa 1734061 gatcctcggc cgcttaaagt tccgtacaag ctacggtcaa aatgtgctta agcattccat 1734121 ggaagtcgca ttcttggccg gtctaatggc atcggagctt ggtgaagacg caaagcttgc 1734181 taaacgtgcg ggtcttcttc acgacatcgg gaaagcaatt gaccatgaag tagaaggaag 1734241 ccacgttgag atcggggtag agcttgcgac caaatataaa gagcacccag tcgtgattaa 1734301 cagtattgca tcacaccacg gggacgagga gccgacttcc attattgctg tactggtagc 1734361 tgcagcagat gcgctttccg ctgcaagacc tggcgcaaga agtgagacgc tcgagaatta 1734421 tattcgaaga cttgaaaaac ttgaagaaat ttctgagtcc tacgaaggtg ttgaaaaatc 1734481 atttgccatt caggctggac gcgaagtgcg aattatggtg aagccggatt caattaatga 1734541 tcttgaggct catcgactgg cgcgagatat ccgcaagcga attgaggacg agctcgatta 1734601 tccaggtcat attaaggtga cagtaatcag agagactcga gccgtagagt atgcaaaata 1734661 aagtgatgcg ctaagcatca ctttattttt ttgacggcaa ggaattttca agaagaaagg 1734721 atttacaaaa tgagaatttt atttatcgga gatgttgtcg gttcaccggg ccgtgacatg 1734781 gtcaaagaat atgtaccaaa gctaaaaaca aaatataagc ctcactttac cattattaat 1734841 ggtgaaaacg ccgcacatgg aaaaggcctg acggaaaaaa tttatcacag cttaatccag 1734901 tccggcgcag atgcaatcac aatggggaac cacacatggg acaaaaaaga aatatttgat 1734961 tttatagatg acgttccgaa cttggttcgc ccggcaaact ttcctgaagg aacaccgggg 1735021 aaagggatca catatgtgaa agcaaacggc aaagaactag cagtcattaa tttgcaggga 1735081 cgtacgtttt tgccgccgct tgatgacccg tttttaaaag cggatgaatt gatcgcagaa 1735141 gctgcgaaaa gaacaccgta catttttatt gactttcatg ccgaagcgac aagtgaaaag 1735201 ctcgcacttg gctggtacac ggatggacgg gcatcggctg tagtaggaac tcatacacac 1735261 gtgcaaacag cggataaccg cattttgccg aagggaacgg catatattac tgatgtggga 1735321 atgactggcc cgtatgacgg tatactgggg atggacagag agacgattat taagcgattc 1735381 aaaacgaacc ttccagtccg gtttactgtc gctgaaggaa aaacaacgct cagcggagtt 1735441 gtcattgaca ttgacgatca aacgaaaaaa gccgtgaaaa ttgagcgtat tttaatcaac 1735501 gatgatcaca tgttctttga atagttgaac atatggttat tttataaaaa tattaaaaag 1735561 aaaagcagga atatagcaac tccttagtga atatagtaaa aatggaaggt agcccgctat 1735621 ttttgaaaag cattgtgggg atggcttttt ggatagcaac atctaataat gattgttcta 1735681 atgaacactc acttatccat tgtaaaacta agggggagca gaaatggaaa tcttaaaagt 1735741 ttcagcaaaa tcgagtccaa attcagtggc aggtgcgctt gcaggcgtgt tgagagagcg 1735801 aggagccgcc gagattcaag cgatcggagc gggtgcatta aaccaggctg taaaagctgt 1735861 ggcgattgcc aggggatttg tggcgccaag cggcgttgat ttgatttgta ttccggcttt 1735921 tacagatatt caaatcgatg gggaagaaag aacagcgatt aaattaatcg tggagcctcg 1735981 ctaaaaacaa ataaagcatt ctcaacctgt ttgcgtaatg caaacaggtt gtttttcatt 1736041 tattgtgata ttttctcccg atagtatttt tagcacataa atgagcgaat atacaaaatc 1736101 agaaatgagc taaaacgttt caaaaaaaat ttccgcccat ttttcaagac agatactttt 1736161 gtccttctgg aaaagacagt tctgtttacg cttattccat atcatggtac aatccgaata 1736221 taacaagaat ttttcaagga ggattgtaca tgcagagtgg aaagatgaaa gctctaatga 1736281 aaaaggacgg ggcgttcggt gctgtgctga ctgaagttcc cattcctgag attgataaac 1736341 atgaagtcct cataaaagtg aaagccgctt ccatatgcgg cacggatgtc cacatttata 1736401 attgggatca atgggcacgt cagagaatca aaacacccta tgttttcggc catgagttca 1736461 gcggcatcgt agagggcgtg ggagagaatg tcagcagtgt aaaagtggga gagtatgtgt 1736521 ctgcggaaac acacattgtc tgtggtgaat gtgtcccttg cctaacagga aaatctcatg 1736581 tgtgtaccaa tactgctata atcggagtgg acacggcagg ctgttttgcg gagtatgtaa 1736641 aagttccagc tgataacatt tggagaaatc ccgctgatat ggacccgtcg attgcttcca 1736701 ttcaagagcc tttaggaaat gcagttcata ccgtactcga gagccagcct gcaggaggaa 1736761 cgactgcagt cattggatgc ggaccgattg gtcttatggc tgttgcggtt gcaaaagcag 1736821 caggagcttc tcaggtgata gcgattgata agaatgaata caggctgagg cttgcaaaac 1736881 aaatgggagc gacttgtact gtttctattg aaaaagaaga cccgctcaaa attgtaagcg 1736941 ctttaacgag tggagaagga gcagatcttg tttgtgagat gtcgggccat ccctcagcga 1737001 ttgcccaagg tcttgcgatg gctgcgaatg gcggaagatt tcatattctc agcttgccgg 1737061 aacatccggt gacaattgat ttgacgaata aagtggtatt taaagggctt accatccaag 1737121 gaatcacagg aagaaaaatg ttttcaacat ggcgccaggt gtctcagttg atcagttcaa 1737181 acatgatcga tcttgcacct gttattaccc atcagtttcc attagaggag tttgaaaaag 1737241 gtttcgaact gatgagaagc gggcagtgcg gaaaagtaat tttaattcca taaaggggga 1737301 taaacatgac gaaggaattt gagtttttaa aagcagagct taatagtatg aaagaaaacc 1737361 atacatggca agacataaaa cagcttgaat ctatgcaggg cccatctgtc acagtgaatc 1737421 accaaaaagt cattcagcta tcttctaata attacctcgg attcacttca catcctagac 1737481 tcatcaacgc cgcacaggag gccgttcagc agtatggagc cggcaccgga tcagtgagaa 1737541 cgattgcggg tacatttaca atgcatcaag agcttgagaa aaagctggca gcctttaaaa 1737601 aaacggaggc ggcacttgta ttccaatcag gcttcacaac aaaccaaggc gtactttcaa 1737661 gtattctatc aaaagaggac attgtcatct cagatgaatt gaaccatgcc tctattattg 1737721 acggaattcg actgacaaag gcggataaaa aggtgtatca gcacgtcaat atgagtgatt 1737781 tagagcgggt gctgagaaag tcaatgaatt atcggatgcg tctgattgtg acagacggcg 1737841 tattttccat ggatggcaac atagctcctc tgcctgatat tgtagagctc gctgagaaat 1737901 atgacgcatt tgtgatggtg gatgacgccc atgcatccgg agtacttggc gaaaacggca 1737961 ggggaacggt gaatcacttc ggtcttgacg gcagagtgca tattcaggtc ggaacattaa 1738021 gcaaggcaat cggagtgctc ggcggctacg ctgcaggttc aaaggtgctg atcgattatt 1738081 tgcgccataa aggccgtcca tttttattca gcacatctca tccgccggca gtcactgcag 1738141 cttgtatgga agcgattgat gtcttgcttg aagagccgga gcatatggag cgcttgtggg 1738201 agaatactgc ctattttaaa gcaatgcttg tgaaaatggg tctgactctc acgaagagtg 1738261 aaacgccgat tcttcctatt ttaataggtg atgaaggtgt ggcaaagcaa ttttcagatc 1738321 agctcctttc tcgcggtgtt tttgcccaaa gtatcgtttt cccgactgta gcaaagggaa 1738381 aagccagaat tcgcacgatt ataacagcag agcacaccaa agatgaactg gatcaggcgc 1738441 ttgatgtcat cgaaaagacg gcaaaggagc tccagctatt gtaacaagag gaagagttta 1738501 ctcttcctct tttgattcct tattgattat tattctcaat gagtgtacaa tgataggttg 1738561 ccagttgtgc agagcttcaa taacctttat actgaagggt ggaagtttgg tttgaaagga 1738621 gaaaatatga catgaatgaa aaacaaaaat tagagagcgg acaagttcat ccatcggaca 1738681 aaaaatccga gaaggattac agcaagtact ttgaagctgt ttacattccg ccttctttaa 1738741 aagacgcgaa aaaacgaggc aaggaagccg ttacttatca taatgacttt aaaatttctg 1738801 aacaatttaa aggattggga gacggaagaa agttctatat ccgtacgtac ggctgccaaa 1738861 tgaatgaaca cgatacagag gttatggcag ggatctttat ggcgctcggt tacgaagcga 1738921 caaactctgt tgacgatgcc aatgtcattt tgttaaatac atgtgcaatc cgtgaaaatg 1738981 ctgaaaacaa ggtgtttggt gagctcgggc acttaaaagc actgaaaaaa aacaatcccg 1739041 atctgatttt aggcgtgtgc ggctgtatgt cccaagagga atcagtcgtg aaccgtattt 1739101 tgaaaaaaca tccgtttgtc gatatgattt tcggaacgca taacattcat cgcctgccgg 1739161 agcttttgtc agaagcatac ctttcaaaag aaatggttgt agaagtttgg tctaaggaag 1739221 gggacgttat tgaaaacctt ccaaaagtcc gaaatggaaa aattaagggc tgggtcaata 1739281 tcatgtacgg ctgtgacaaa ttctgtacgt attgcattgt gccttacaca cgcggaaaag 1739341 aaagaagccg ccgccctgag gatatcattc aggaagtgag aaggctcgca agtgaaggct 1739401 ataaggaaat tactctgtta ggccaaaacg taaacgcgta tggaaaagac tttgaagata 1739461 tgacgtacgg acttggtgat ttgatggatg aactgagaaa aatcgatatc ccgagaatcc 1739521 gttttacaac gagtcatccg cgcgactttg acgaccgcct cattgaagtg ctggcaaaag 1739581 gcggaaatct gcttgatcac attcatcttc cggttcaatc aggaagctca gaagttctca 1739641 agctgatggc ccgcaaatat gacagagagc gttacatgga gctggtgcga aaaattaaag 1739701 aagcaatgcc aaacgcttct ttgacaacgg acattatcgt cggatttcca aatgaaacgg 1739761 acgaacagtt tgaagaaacg ctttctctat accgtgaagt ggagtttgac agcgcctata 1739821 cgttcattta ctctccgcgt gaaggcactc cggctgctaa gatgaaagat aatgtaccga 1739881 tgcgtgtgaa aaaagaacgc ctgcagcgtc taaacgcact ggtgaatgaa atttctgcta 1739941 aaaaaatgaa ggaatacgaa ggcaaggttg tcgaagtatt agttgagggt gaaagcaaaa 1740001 ataaccctga tattcttgct ggctatactg aaaaaagcaa gcttgtcaat ttcaaagggc 1740061 cgaaggaagc catcggcaaa atcgtccgcg tgaaaatcca gcaagcgaaa acatggtcgc 1740121 ttgacggaga aatggtagga gaagcaatcg aggtgaaatg agatgacgct ctactcaaaa 1740181 aaagacattg tgcagcaggc tcgaaacctt gcaaaaatga tttctgaaac agaagaggtt 1740241 gattttttca aacgggctga agcgcaaatc aatgagaatg acaaagtgtc cacaatcgtt 1740301 aatcagatta aagccctgca aaagcaggct gtcaatctga agcattatga aaagcatgaa 1740361 gcgctcaaac aagtagaagc aaaaattgac gcgctgcaag aagagcttga agagattcct 1740421 gttatccagg aattcagaga ctcgcaaatg gaagtaaatg acctactgca gctcgttgca 1740481 cacaccattt ccaaccaagt cacaaatgaa atcatcacat caaccggagg cgacctgctg 1740541 aaaggggaaa ccggttcaaa ggtgaagcat tcaaataaca gctgttctct ctaaacacgg 1740601 tgcctttaca ggcccgtgtt tttttatcat ttgtgcggtt aaaaatgaac taaataatct 1740661 atgtaccaaa tgttcaattg gtttttctgt gctcagccgc gtataaactt tatcgcactt 1740721 ataagtaaag tttctaggca cccctgcata caatggaaca gaaactttgt atttttatat 1740781 tttatttata aaaatgcaca ctagacaaat gcccagcata agataacacg aagaagaaca 1740841 aggaggcatg ccggaatgtc tgaatacagg gaaattatta cgaaggcagt agtagcgaaa 1740901 ggccgaaaat tcacccaatg caccaacacc atctcgcctg agaaaaaacc gagcagcatt 1740961 ttgggtggtt ggattattaa ccacaagtat gacgctgaaa aaattggaaa aacggtagaa 1741021 attgaagggt attatgatat aaacgtatgg tactcttacg cggacaacac aaagacagag 1741081 gttgtcacag aacgggtaaa atatgtagat gtcattaaac tcagatacag agacaataat 1741141 tacttagatg atgagcatga agtgattgcc aaagtgcttc agcagccaaa ctgccttgaa 1741201 gtgaccattt cgccgaatgg aaataaaatc gttgtgcagg cagaaagaga atttttggcg 1741261 gaagtggtag gggaaacaaa ggtagttgtt gaggtcaatc ctgactggga agaggatgac 1741321 gaggaagatt gggaagatga gcttgatgaa gagcttgaag acatcaaccc ggagttttta 1741381 gtgggagatc ctgaagaata aaaaagggac taggggagac agtaccccca agtctctttt 1741441 ttatattgat atatcattct tttatcactt tttgtttatg ttataatgaa ggttggaaaa 1741501 tagaaacgtt gatacatagt gagggattaa acaatggccg gttatacgcc tatgatacag 1741561 caatatttaa aaataaaggc agagcaccag gatgcctttt tattttttcg cctgggtgat 1741621 ttttatgaaa tgttttttga ggacgccaaa aaagcgtcac aagagctgga aattacgtta 1741681 acgagcagag acggcggtgc ggctgaaaaa ataccgatgt gcggtgtgcc gtatcattct 1741741 gcttccgcgt atatcgaaca gcttattaaa aaaggataca aagtggcgat ctgtgaacag 1741801 acggaagatc cgaaagccgc aaagggcgtt gtgaaaagag aagtagttca gctgattacg 1741861 cccggaactg taatggacgg caaaggcatc catgagtcgg aaaataattt tatcgcatct 1741921 gtttcagcct gctcgaacgg atacggactt gctctgtctg atttaacaac gggagaaaat 1741981 ttggctgttt tgattgaacg gcttgaagac gtcatatcag aaatttattc agtcggcgca 1742041 cgggaaatcg tggtttcagg aagcttggat gccgatacag tggcacagct gagagagcgg 1742101 tgcggtgcaa cgatttcaat tgaagacgga gaaacagacg aacacgtaac gatcattgag 1742161 cacttaaata atgaagatat aacaaaaaca tttctgcgct tatatacgta tttgaaaaga 1742221 acccaaaagc gcagccttga tcatcttcag cccgtgcagg tgtatgagct tgaggaagcg 1742281 atgaaaattg acttgtactc aaagcgtaat ctggagctga ccgaaacgat tcgttcgaaa 1742341 aataaaaaag gctccctttt gtggctgctg gatgaaacaa aaacggcaat gggaggccgg 1742401 ctacttaaac agtggattga ccggccgctt atcagagtca atcaaatcga agagcgccaa 1742461 gaaatggtgg aaacattaat gtcccatttc tttgaacggg aagatctgcg tgaacgttta 1742521 aaagaagtat atgacttaga acgccttgcc ggccgcgttg cattcggaaa tgtcaatgcc 1742581 cgggatttga ttcagctgaa ggaatcgtta aagcaagtgc ctggcatcaa acagctggtt 1742641 gcttcactgg ctcatgacaa ggccaaggaa cgtgcaaagc gcattgaccc ttgcggggat 1742701 gtacttgaac tgctggaaga agcgctgtac gaaaaccctc ctttatcggt aaaagaaggg 1742761 aacctgatta aagatggtta taatcaaaag cttgatgaat atcgtgatgc aagcagaaac 1742821 ggaaaagact ggattgcccg cctggaacag caggagcggg aatacacagg cattcgctct 1742881 ttaaaggtcg gctttaataa agttttcggt tattacattg aagtgacaaa agcaaacttg 1742941 catttgcttg aggaagggcg ttatgagcgg aagcagacgt taaccaatgc agagcgctac 1743001 attacacctg aattaaaaga aaaagaagcg ctcattttag aggcggaaaa taacatctgt 1743061 gagctggagt acgagctgtt taccgagctg cgcgagaaag tgaagcagta tattccgcgg 1743121 ctgcagcagc ttgcaaaaca gatgagcgag ctggacgcac tgcaatgctt tgcgacaatc 1743181 agtgaaaatc gccactacac gaaaccagag ttctctaaag atgaagtcga agtgattgaa 1743241 ggcagacacc cggttgttga aaaagtcatg gacagccagg aatatgtccc gaacaactgt 1743301 atgatgggcg ataacagaca aatgcttctc attacaggtc caaacatgtc agggaaaagc 1743361 acgtatatga gacaaatcgc gctcatttcc attatggcgc aaatcggctg ctttgtaccc 1743421 gcgaaaaaag cggtgctccc gattttcgat caaattttta cgcgaatcgg cgctgcagat 1743481 gatttgattt ccggacaaag tacatttatg gtagaaatgc ttgaagcgaa aaatgcgatt 1743541 gtcaatgcga cgaaaaacag cctcattctg tttgatgaaa tcgggcgggg aacgtccact 1743601 tatgacggca tggcgctggc acaggcgatt attgaatatg ttcacgatca tatcggcgcc 1743661 aagacgctgt tcagcacaca ctatcacgag ctgaccgttc ttgaggacaa gctgccccag 1743721 ctgaaaaacg ttcatgttcg cgctgaagaa tataacggaa cggttgtctt tcttcatcaa 1743781 attaaagaag gtgcggctga taaaagctat ggtatccatg tagctcagct tgccgaactg 1743841 ccgggagatc tgattgcgcg cgctcaagat attttaaaag agcttgagca ttcaggaaac 1743901 aaaccggaag tgccggtgca gaaacctcag gtgaaagaag agccggcaca gctgtccttt 1743961 tttgacgaag cggaaaagcc ggctgaaaca ccaaagcttt caaaaaaaga aaagcaagtg 1744021 atcgatgctt tcaaatcact taatatactg gatatgacac cgcttgaagc gatgaatgaa 1744081 atgtacaagc tgcaaaagaa attacattaa aacggggtga tgaatgtggc aaaagtcatc 1744141 caactgtcag atgagctttc aaataaaata gcggcgggcg aggttgtgga acggcccgcc 1744201 tcagtcgtca aagaattggt ggaaaatgcg atcgacgctg acagcacagt cattgaaatc 1744261 gatattgagg aagcaggcct tgcatccatt cgggtcttgg ataacggcga aggaatggag 1744321 aatgaagatt gcaagcgagc tttccggcgc cacgcaacga gtaaaataaa agatgaaaat 1744381 gatttattca gggtgagaac gctcggtttc aggggagaag ccctgccgag tatcgcgtca 1744441 gtctctcatc tggagattac aacaagcact ggtgaaggag ctgggacgaa gctcgtcctc 1744501 caaggaggaa acatcatttc cgaatcgcgt tcctcaagca ggaagggaac tgaaattgtc 1744561 gtttccaacc tgttttttaa cacaccggcc cgtttgaaat atatgaaaac cgttcataca 1744621 gagcttggaa acattacaga tgtggttaac cgtattgctc tggcgcatcc agaggtatcg 1744681 atccgcctgc gccatcatgg gaaaaacctg cttcaaacga acggaaacgg agatgtgcgc 1744741 catgtactgg cagcgattta cggcacggct gtcgccaaaa aaatgcttcc gctgcatgtg 1744801 agctccttgg attttgaagt aaagggatat atcgccctcc cagagattac acgggcgtcg 1744861 agaaactata tgtcgtctgt ggtcaatggc cgttacatta aaaatttccc gctcgtcaaa 1744921 gcggttcatg aaggctatca tacgcttctg ccgatcggac gccatccgat tacttttata 1744981 gaaattacga tggacccgat tttagtcgat gtcaacgtgc atccatcgaa gcttgaggtc 1745041 cggctcagca aggaaacaga gcttcatgac ttaatacgtg acggaattaa agatgtgttt 1745101 aaacagcagc agctgattcc tagtgcccag gtcccgaaaa aatcagcacc tgccatcaaa 1745161 aatgagcagc agtttataac ctttgatgaa aagcctccgg aaaaaaaagt tccggaaaaa 1745221 tcgactgcgc catcttattc accgatgaag ctcagctcag tcgtaaaaga gccggttgat 1745281 gcggaggaaa aattgccccc tctccaattt gatgctcctc ctatcgttga tcaggaacaa 1745341 acccttgagg tgtccgatgt ttcagcagaa cagcctgaaa catttgagca ggaatgccat 1745401 gaggaacagc cgcagccagc gtctgatcgg gttccaatta tgtacccgat tggccagatg 1745461 cacgggactt atatattggc acaaaacgaa aacggcctat atattatcga ccagcacgcc 1745521 gcccaagaac gtattaaata tgagtacttc cgtgaaaagg tgggggaggt tgagcctgag 1745581 gtgcaggaga tgattgtacc gctgacgttc cactactcca caaatgaggc tttgattatt 1745641 gaacagcaca aacaagagct cgaaagcgtc ggtgtctttt tagagtcatt cggctctaac 1745701 agttacatcg tccgctgcca cccagcctgg tttccaaagg gagaagaagc agagcttata 1745761 gaagaaatca ttcagcaggt gctcgactcc aaaaatatag atattaaaaa acttcgcgag 1745821 gaagcggcga ttatgatgag ctgcaaaggc tccatcaaag caaatcgcca cctcagaaac 1745881 gacgaaatca aagcgcttct ggacgacctc cgaagcacat cagacccatt tacatgcccg 1745941 cacggccgcc cgatcatcat tcaccactcg acatatgaga tggaaaagat gttcaaacgc 1746001 gtgatgtagc gggggtggta ggcattgatc cattctctga atggatcaat gctttttttg 1746061 tactccttcg agtgtcagat tataagaaac ggttgtaaac gtgtgagcag tgttaacgca 1746121 ttatacttca tggttcctcc gtataacaaa atttccattt acaggcaatt gggattaatg 1746181 tatattttgg gtgagggggt ggaaacatat ggcatgtggt ccgaagatca ttatcttttt 1746241 ggatgaactt gatgatccaa atgtgagaat cattttagaa tgcagaattt aaattacaac 1746301 attgtgtttt gctccctgtt cgtgtgaaca gggagatttt ttcgtttata taactggtga 1746361 tgtccaaata tagggtgtta tgaattttcc atatctgcca tcggctttaa gctgcttctc 1746421 tattaggctg gttatcaaaa gcaagttcaa tgatagccat gaaagctgat atcacaacaa 1746481 gcaagacatc tggaatataa atagactgca taaagtaatc tgcaaaacag atcgttataa 1746541 gattgctgat aaaatacagt ataaaagcaa aaagtgcagt ctttttcaat gaaagtgatt 1746601 ttgccaaaat gatagagata atctttgtga gtgggtctat gattaaacct acagcaaagc 1746661 aggctaaaat aaataaagct aatgtttgat tggaagcgta tgtgatgcca agtatggaga 1746721 ataagccttt catcccgaag aaaaagccgc cgaagatgac tgcaagcgcg atggccgcga 1746781 taaaagtaat agatacaatt ccgattaatt ttgatctcag gttaaaatct ttagagtgct 1746841 cgttctgttc tttttggttc atgtatgaca ctcccttcac ctgcttactc atacaaacag 1746901 cacccttgaa tcagcccaaa atatctataa gtctgttttc tgacgaaaat agtatagcat 1746961 attttaacaa aaccaaaaaa ggccctttcc actggggaag ggcctttttc atcatgttaa 1747021 ctcctgagat tcgccgaagc tttctctttt tttggccaaa taaaatagct ggctgtaatg 1747081 agaaagtcaa tgcctataat gacagtccac agtttaagaa tgccgctcaa cgcctcggtt 1747141 cgggaagagt cattgataaa atagatcatc cctgccaata gtcccgcacc aattaagtag 1747201 gccagcacat gtcttagcca gcctttcgca ccgtgcttgg catggtccat tccaaaacgt 1747261 ttcagcggtt ttgttccttt ttttgtcaca taatattgaa acttttcatc tgcccattga 1747321 atcatttgtt tcccataagc gatcgatata ccgatgtaaa cagctgcaat cccatgggct 1747381 gcggtcgctg aggctccgcg gtaaaggtcc acaccagttg ccgctaacaa gatcaaatcg 1747441 ataactggag ttaaggcaag gaatagcagt cctaatgtat gtcgtttgaa tacgtagcgt 1747501 acagcaagcc ccaaaacaat gacaacccaa aacgcaattt cacagaaaac aatcatccat 1747561 gcgataccgt tcaatccatt cccctctttt caatacagtt gtattattta aataatatgt 1747621 taccatcttt gtttttgtaa cacaactgta ttataaaaat tgccctctca tttttttctt 1747681 gttacaataa agctatgcca aaacaaattg accatgagaa aagaagaaaa caaattgcag 1747741 aagcaacgtg gcgcgtcatt ttagaacgag ggatggaggg agcatcagcc agaaatattg 1747801 caaaggaagc aggattgtca ttaggtgcgc tgcgccatta tttctctaca caggatgaat 1747861 tgcttgcttt tgcaatgaaa cttgtccaag aaaaggtaac ggaccgaatt aaggacattg 1747921 cagtgaggga tttgctccct aaggaaaaag tgttgcaaat tttgcttgaa atggtcccaa 1747981 cgaatgaaga aacgattaga gagatggagg tttggtttgc ttttactgct tacgccagac 1748041 ataaaaagga tatgtttgat gcgagtcatg acgggatttt cagcggcatg cggaatctga 1748101 ttgcctattt agatgaatcc gatttactga agcagaatgc tgataaagac attgaagctg 1748161 agagacttta cgcgcttgtt gacggcttgg ctttacatgc catgcttgac cctgtgcgcg 1748221 tgaataaaga ccgaatcaag cgggtcatta tgcagcatgt agagtcaatt tgcgtggaag 1748281 atacacgtga gacacaaaaa cgacatcctt aaggcactag tgtgaaaagc gattcttgtt 1748341 gggcatgcgt ccaaaagagt cgctttttta ttttcaaaga acaaggatct ctgaaaaaaa 1748401 tggaaaacaa tcatgctgtt tggtaaagtg gaatgaaaga cggactgagg ggtgaacact 1748461 ggtccatcgt ttaagaactt tacatgatag ggatggtata aatgaatctt acttacaagg 1748521 tgcatccaat taaaacaagg tatcagggct ggacgaatta ttgctatatc attgaagata 1748581 ttgtaagcag atctgcaatt gttgttgatc cctcatggga attgagtaag ataaccacta 1748641 cactttccga actcgaagcg gaattaaagg cagtcgcatt gacacactct cattatgatc 1748701 atgtaaatct ggtagacccg ctgacgaaga tgtttaacgc tcaagtttat atgtcgaaaa 1748761 aagaaattga ttattatcaa ttccgatgca gaaatttaat tagcctagat gatcatcaga 1748821 cgatcagcat aggaaacaca agagcacagt gccttctcac accggggcat acagccggcg 1748881 gaatgtgtta tttgttttct gagagtattt ttaccggaga tacggtgttt acagaagggt 1748941 gcggcatatg tgaggatgat ggcagctctg cggaagagat gtttgatagc attcaaagaa 1749001 taaagtcgga ggtttcaccc catgtacggg tgtatcctgg tcactcattt ggcaaatcgc 1749061 ccggccattc gataaaggat ctttatcagc ataatattta ctttcaaatt gataagaaag 1749121 aatattttgt gaaatttcgc actcgtaaaa accaaaaagg tatttttgat tttaaataat 1749181 ccttctgaat ctattatcct atttttcttc gaatatctaa atgattttta ttttcgaaaa 1749241 tgattacata gaaggtgtta tttattttga aaactcattt gaaagaaaat gaagcgcatt 1749301 atcatgatat ggcgccctat atgtaatccg ggtctttttt cttatgttct gttatatctc 1749361 ctgatccttt attcctcaat ggaaaaaagc agaaaaacaa tggagcaaac tgtaggaaaa 1749421 attaacttga cggataatat ttacagaggt taccatcaac atgaacatgc tactatttat 1749481 ccggtcatca ctattataaa atcatacaga agtgaaacac atctactaat cggaagggtg 1749541 gctttgagag aatgatcaca tatgtttttc caggtcaggg ttcacaaaaa cagggaatgg 1749601 gcagcggcct attcgatgaa tttaaagaac tgacggatca ggcagatgag atcttaggat 1749661 attctatcaa acgtctttgc ctggaaaatc cttattccaa tttaaacaaa acgcaattta 1749721 ctcagccggc attatatgtg gtaaacgcac taagctatct gaaaaaaatc agggatgaag 1749781 aagttaaacc tgactttgtc gccgggcaca gcttgggtga atacaatgcg ttatttgcag 1749841 ctgaagcctt tgattttgag acaggtttac agcttgtcag aaaaagaggc gagctgatga 1749901 gtctgataag caacggcggt atggcagctg ttatgggact aaatgaagag caggttgcaa 1749961 aggctctgaa agaatatcat ttacatgatg ttgatatcgc taatgtgaat gccccatatc 1750021 aaattgtaat ttcaggaaaa aaagatgaga ttgaaaaagc cgcatctctt tttgaaacga 1750081 tgactgaagt tacaatggta ctccccttaa acgtaagcgg cgcgtttcat tccagataca 1750141 tgaataaagc aaaagaagaa ttcgaggagt tccttcatgc cttttatttt tcgcctccgt 1750201 ctatcccggt tatttctaat gtgtatgcca aaccgtatac atacgaattc atgaaacaga 1750261 cgctggctga tcaaattaat cattcagtga aatggactga cagcataagc tacttaatga 1750321 aaaaaggcca tatggagttt gaggaggtag ggcctggaaa tgttttaact gggttaattc 1750381 atcgcataaa gaaagatgcg gaagcaatgc cccgctaaag catttgcccc tatggccatg 1750441 tatctcatca atcaggtcta aacacagatt tcctttcatt taaggtataa agttttaaag 1750501 attcaatcgt tcgattgaca ctgtttctaa ttgaataact ttatatactg ttacataaag 1750561 aggctgataa attaagttag acatttgaac tatgtcagcc ggtctgtcaa accatcgctc 1750621 ccacatctag atggtccatt tttaaaccgc acccaccaat catagagtcg atgttctttg 1750681 ctgatcctgt tatcatgtta catcaatttt gagatatcaa catacatcta cgatcacgtc 1750741 ataaatgaac cacatccaga gcaccaatag caatccttcc aagttgaatc tcctttactt 1750801 tttcacatat gtcttttcca tttattaatt tcatttcaat cgctgctatg tgctttaaca 1750861 acatgcatgg aaatgagaaa tccaatagcc gtcataaata taaaaaaaga aggttataca 1750921 catgaatgaa ccgcttgttt ttatgttttc cgggcaaggt tcccaatact atcacatggg 1750981 gaaagaacta tttaaggaaa ataccgtgtt tcgccaatca atgcttgaaa tggatgccat 1751041 tgcagcacgg cgaatcggca catccattgt tgaagaaatc taccatccag gtaaacgtgt 1751101 gtcagatccg tttgacagta ttcttttttc ccaccccgcc atttttatga ttgagtattc 1751161 cttatataag gttttggaag acaggggaat ttatcctgat tacgtattgg gatcaagtct 1751221 gggagaattc gcagcagcgg cagtttctgg tgtgtcagac gcagaggata tgctggattg 1751281 catacttgaa caggctatta tcatccagaa ttcctgcgat aaaggaaaaa tgctggccat 1751341 tcttgacaaa ccgcaattgc tgaatgatca tccgcaactg tttggaaata gtgaactcat 1751401 ttctatcaat tatgattcgc acttcgtcat ttctggtgaa gaagatcata taaggaagat 1751461 tatggaggat ttaaaggaga agcagattct ttgccagctg cttcctgtgt cctatgcctt 1751521 tcattcttcg cttattgatc cggcagagag tgcctatgca gaatttttaa gatcaaaatc 1751581 ttttcaaaaa ccgtcaatac cgattgtatc gagcttaacg ggaagctgcc ttcacgtaat 1751641 ggacgagaat ttcttttgga atgcggtcag aaagccaatg atgtttcgtg aagcgattcg 1751701 atatttggaa agccagcata catgcaagtt tatcgattta gggccatccg gcaccttagc 1751761 tgcttttgtg aaacagctga ttccgggtga ttcagctgac cgttgctgct caatcataac 1751821 accatttcat caggagctga aaaatctgaa tacggttgag tatttccgta caccagaaag 1751881 gaagtttaca agatgattac atatgtcttt ccagggcaag gctcccagca aaaggggatg 1751941 ggacaagggc tatttgaaca gtatcagcat ttgacagatc aagcagatca aatattgggc 1752001 tattcaatag agaagctatg taccgaaaaa tcatatctgg atgtaaatca tactgaatac 1752061 acgcagccgg ctttgtatgt tgttaatgca ctcagttact tgaagagagt ggaggagacc 1752121 ggcagaaaac ctgattttgc ggcaggacac agcttaggag aatacaatgc gctgatggca 1752181 gccggtgcat ttgattttga aaccggatta aggctcgtca aaaaaagagg agaattgatg 1752241 ggacgaatta cagggggcgg aatggctgct gtgatcggcc tgagtaagga acaagttaca 1752301 gccgttttag aagagcaccg tctttatgac attgatgtgg caaatgaaaa tacgccccag 1752361 caaattgtga tttctggccc gaaaaaagag attgaaaaag ctcgggctgt ttttgaaaac 1752421 accaaggatg taaagctgtt tcatccatta aatgtgagcg gagcttttca ttccagatat 1752481 atgaatgaag ccaaacaggt atttaagcaa tatattgact cattccagtt tgcacctttg 1752541 gcgatcccgg ttatctccaa tgtctacgca gagccatacc atcaagacag attaaaagat 1752601 acattatctg aacaaatgga caacacagtg aaatggacgg acagcattcg ttttctgatg 1752661 ggaagaggag aaatggagtt tgcagagatt gggcctggaa ctgttttaac cggtctcatt 1752721 catcggatta aaaatgaagc tgaaccattg acatatatac cgaaaaagaa ccccgcgatc 1752781 agtgcgcatc taaaggagca acgcaatgtt caagccggga ttacggcaga atctttagga 1752841 agtgctgaat ttaaacaaga ttatcatctt acatatgctt atcttgcagg aggaatgtac 1752901 cgcggcattg cttcgaaaga aatggtagta aagctgtcaa gagcgggaat gatggggttc 1752961 tttggcacag gaggtctgag cctgaaagag gttgaagatg cgatccatgc tatacaaggt 1753021 gaattaggaa aaggacaagc ctacggcatc aatctggtcc acaatatgaa acatactgaa 1753081 tcagaagaaa aaatgatcga tcttttattg aggaatcaag tgagcattgt ggaggcttca 1753141 gcatttttaa gtgtcactcc tgtattagta aggtatcgcg caaaaggagt gaaacgaaat 1753201 caaaatggtg acgttatatg ctcaaatcgt ctcatagcaa aaatatcacg gccggaagtt 1753261 gcagaatcat ttctgagtcc tgcgcctgag aatatgctgc aaaagctttt aggagaaaat 1753321 aaaatcacta tgaacgaagc tgagttgttg cggtgcattc cgatggctga cgatatttgt 1753381 gtagaagctg attcaggcgg tcatacagat ggcggtgtgg catacagcct gatgccggcg 1753441 atgacatctt taagagatga aatgatgaaa aaatatcaat accggaaaaa aataagagtt 1753501 ggtgcagctg gaggaattgg aacacctgag gcagcgatgg cggcttttat gctaggggct 1753561 gattttattc taacaggctc aatcaatcaa tgtacggttg aggcggcaac aagtgataaa 1753621 gtaaaggatt tgcttcagca gatgaatgta caagatacag cctatgcgcc tgcaggtgat 1753681 atgtttgaat cgggcagtaa agtgcaggtg ctaaagaaag gcgtgttctt tcccgcacgg 1753741 gcaaacaagt tatatgaact gtatcagcgg tatgggtcta tacgtgagct ggatgcaaag 1753801 atgctggccc agcttgagga gaaatacttt aaacgcagta tagaagacat atataaagat 1753861 attgcattgc attatcccgc ggcagacatt gagaaggctg aacaaaaccc gaagcataaa 1753921 atggctttga ttttccgatg gtacttcaga tacagttcaa aattggcaat cagcggaagc 1753981 gaacattcga aggtcgatta tcaaattcac tgcggtcccg cgctgggagc ctttaatcaa 1754041 tgggttaaag ggtcgcaatt agaaaattgg cgaaaccgcc atgtggatga aatcgggaaa 1754101 aaattaatga cagaaacggc agtattgctt catgaacgga tgcaatcgat gtatcagccg 1754161 tcgcatgaaa cagacaacat aaaaataaaa gtttgaatat tatgaaaata tacctataaa 1754221 aatcattaaa ataatccctt gaaggagaga gcgcattatg gataaacaga gaatctttga 1754281 agtattaatc accaatattt gcgaggtgct tcctgaatta gacggacaca gatttgagcc 1754341 tgaagatcag ttagttgagc taggagctga ctctgtagac agagctgaaa ttatcacgat 1754401 ggtgctagag gatttatcgt taaaaatccc tcgcattgag ctatccgggg tgaaaaacat 1754461 cggtgaatta gctgaggtgc tttatgacaa agtgcaatct gcctgaggtg gtggtgaccg 1754521 gtgtaggcgt tacggcctct atcggtcaag ggaaagagga ctttgcttcc tcgctgctgt 1754581 ccggcagaca tgcctttgat gtcatgaagc gttcaggcag acaaaaagac agccggttta 1754641 tcggagccga aattgcgtca ttgtcttatc ctgaccgact ctctaaaaaa atgttgcgaa 1754701 aagcatcatt ctccagccgc gctgcattgg taactctcac agaggcttgg gaggaggctg 1754761 aattggacga tgcagattcc tcacgtatcg gactggttgt tggcggatca aattttcaac 1754821 agagagaaaa ctttgaagtt tatgaaaggt atcaagaccg ctccggtttt atttctccgg 1754881 cgtatggtct gtctttcatg gacagcgatc tttgcgggat atgtacagat cagtttggca 1754941 tcacgggatt agcatatacg gtgggaggag cttcggccag cggccagtta gcagtcattc 1755001 atgcgattca gcaagtcctg tcaggcgaag ttgatacttg catagcactt ggtgctttaa 1755061 tggatctttc ttatatggaa tgcgaggcgc taagggcttt aggcgctatg gggacggaca 1755121 aatatgctga tgaacctgaa aatgcgtgcc gtcccttcga tcaaaacaga gacgggttta 1755181 tctatggaga atcgtgcggt gcattggtaa tagaacgaaa ggagacggct ttacgaagag 1755241 gtctaaaacc ttatgcagca ttgtctggct ggtcaatcaa actggacgga aaccggaatc 1755301 ctgatccttc attagaagga gagattcatg tcatccagaa ggcactggag cgtgccaggc 1755361 ttttaccaga agatattgat tatattaatc ctcatggaac aggctctttt attggagatg 1755421 aaatagaatt aaaggcgctc cgtgcatgcc ggctttccca tgcttatatc aatgcaacaa 1755481 aatcgataac cggacacggg cttagtgcgg cgggcatcgt agagattatt tctgttttgc 1755541 tgcaaatgaa aaaatctgcc ctgcatccga gcaggaattt ggatcatcca atcgatgatt 1755601 cctttcattg ggtaaatgag aaatcgattt cataccgcat caaaaatgcg ctgagcttaa 1755661 gcatggggtt tggcggaatg aacaccgcgg tttgtataca aaacattgag aaatgtggag 1755721 gcgaatcata aatggtttca gccggaatag aagcgatgaa tgtctttggc ggaacggcat 1755781 accttgatgt catggagctg gccaaataca gacacttaga tactgcgaga tttgaaaatt 1755841 tattaatgaa agaaaaagcg gtagcactgc cttatgaaga tcccgtgacc ttcggagtca 1755901 atgcagctaa gccgattatt gatgctttat ctgaagcaga gaaggaccgg attgaattgc 1755961 tgatcacttg ctctgaatcc gggatcgact ttgggaaatc gttaagtaca tatatccatg 1756021 aatatttagg tctcaaccgc aactgccgtt tgtttgaggt taaacaggcg tgttattcag 1756081 ggacagcggg atttcagatg gcggtgaatt ttatattatc ccagacttct ccgggtgcca 1756141 aagcactggt tatcgccagt gatatttcac gttttttaat cgctgagggc ggagacgctt 1756201 taagcgaaga ttggtcttat gcggaaccga gcgccggagc gggagcggtg gccgttttag 1756261 ttggcgaaaa tcccgaggtg tttcaaatag atcccggagc aaatggttat tacggctatg 1756321 aagtgatgga cacgtgccgc cccattcccg acagtgaagc gggagattct gatctgtctt 1756381 taatgtcata tttggattgc tgcgaacaga cttttctgga atatcaaaag cgtgtaccgg 1756441 gtgccaatta tcaggacacg tttcaatatc ttgcttacca tacgcccttt ggcgggatgg 1756501 tgaaaggtgc gcaccggaca atgatgcgta aggtagcgaa ggtgaaaaca tccgggattg 1756561 agacggattt tttaactcgg gtaaaaccag gtttaaacta ctgtcaacgg gttggaaata 1756621 ttatgggggc agccttgttt ctggcattgg ccagcacgat agaccaaggg agatttgata 1756681 cgcctaaacg aattggctgt ttttcctacg gatccggctg ctgttctgaa ttttacagcg 1756741 gaattacaac tccgcaaggc caggagcgtc agcgaacatt tggtattgag aagcatttgg 1756801 atcgccggta tcagctctcc atggaagagt atgagctatt gtttaagggg agcgggatgg 1756861 tgcggtttgg gacgcgcaat gtaaagctgg actttgagat gataccgggc atcatgcagt 1756921 ccactcaaga gaagccgcgc ttgtttttag aagaaatttc tgagtttcat cggaagtaca 1756981 ggtggatctc gtgacctatc aaacgataaa ggtccgcttt caagcatcgg tttgctatat 1757041 tacctttcac cgtcctgaag cgaataatac gattaatgac acgctgatag aagaatgctt 1757101 gcaagtgtta aaccaatgtg aaacatcaac ggtgacggtt gtcgttttag aggggcttcc 1757161 cgaggtgttt tgtttcggag cggattttca agaaatctat caggaaatga aaaggggcag 1757221 aaaacaggca agctcccaag agcctctcta tgatttgtgg atgaaattgc agaccggccc 1757281 ttatgtcacg atttcgcatg tcaggggaaa agtgaatgcc ggcggtcttg gatttgtatc 1757341 tgccacagat attgccattg ctgatcagac ggcgtcattc agtctctctg agctgctatt 1757401 cggcctgtac cctgcttgtg ttttaccgtt tctgatccgc cgtatcggcc ggcagaaagc 1757461 gcattatatg acgcttatga caaagccgat ttccgttcag gaagccagtg aatgggggtt 1757521 aatagatgct tttgatgctg aaagtgacgt gctgctgaga aagcatttat tgcgtttgcg 1757581 gaggctgaat aaaaaaggaa tcgcacatta taaacagttt atgagctcac ttgatcatca 1757641 agtcagtcgt gcgaaagcca ccgctttaac tgcaaatcaa gacatgtttt ctgatcctca 1757701 aaaccaaatg ggaatcatca ggtatgttga aacaggacaa ttcccatggg aggatcagta 1757761 accgtttaaa aatgacaatc agaaccgtta ggaggacatc atgacgcatt ctgttgtaga 1757821 gcttatcgaa attgaatccg ccattattca ggtaaagatg caagatcgca ctcataaaaa 1757881 cgcgttttca caagaactta cagacgattt aattcaagcg tttgaataca tacggcagaa 1757941 tcccaaatac aaagcggtca ttttgacagg atatgataat tattttgctt caggaggaac 1758001 gcaagaagga ctgcttcgaa ttcaacaggg attgaccaag ttcactgatg acaatcttta 1758061 ttctctggcg ctggattgcg agattccagt tattgcggca atgcagggcc atggaattgg 1758121 aggcggcttt gtcatggggc tctttgctga cattgtcatt ctgagcagag aaagcgtgta 1758181 tacggctaat tttatgaaat acggatttac gcctggaatg ggcgctacct ttatcgttcc 1758241 taaaaaactg ggtttcagcc tggcccagga aatattattg aatgcgggca gctaccgcgg 1758301 agctgatctt gaaaaaagag gggttccttt taaggtgctg ccccgtgcag aagtgttaga 1758361 ttatgcagtg gagctggcgc aagaactggc ggaaaagccg agaaactcac tggttacact 1758421 gaaagatcat ttggttgccc cgcttcgcga tcagctgccg cgcgtcattg aacaggaatt 1758481 gatgatgcat gagaaaacat ttcatcatga agaagtcaaa agtagaatca aaggtttata 1758541 tggtaattaa ctgaaaatat atataaattt tgcaggtgaa atggaggcag cgtgatgaga 1758601 aataatgata atatccgcat attaactaat ccttctgtca gtcatgggga gcctttacat 1758661 atatctgaaa agcagccggc aacaatacct gaagttttat acagaacggc gacggagctt 1758721 ggggatacaa agggaatcat ttatttgcag ccggatggaa ctgaagttta ccaatcatac 1758781 agacgattat gggatgatgg attgcgcatt gcgaaggggc ttcgccaatc aggcctgaaa 1758841 gcaaaacaaa gcgtgatttt gcagcttggt gacaattcac agcttctccc tgcgttctgg 1758901 gggtgtgtgt taacaggggt tgttccggct ccattagccg ttccgccaac gtatgctgaa 1758961 tcgagcagcg gcactcaaaa gctgaaagac gcatggacgc ttcttgataa gccagcggtg 1759021 attacggacc gggggatgca tcaggaaatg ctcgattggg caaaagaaca agggcttgaa 1759081 gggttcaggg caattattgt agaggatctg ctcagcgctg aagcggacac agattggcat 1759141 caatccagtc ctgaagactt agcgctttta ttgctgactt caggcagtac gggaacgccc 1759201 aaagcagtta tgcttaatca tcgtaacatt atgagcatgg tgaaagggat tattcaaatg 1759261 caaggcttca ccagagagga tattacgttt aactggatgc cgtttgacca tgtcggaggg 1759321 atcggaatgc tgcatttgcg ggatgtttat cttggctgtc aggaaattaa cgtctcaagc 1759381 gaaacgatct taatggagcc gttgaaatgg ctggattgga ttgatcatta ccgagcttct 1759441 gttacgtggg cgccgaattt tgcgtttggt ctggttactg attttgcaga agaaataaaa 1759501 gataagaaat gggatctgtc ttcaatgcga tacatgctca atggcggtga agcaatggta 1759561 gccaaggtag ggcgtagaat acttgagctt ttagaaccac atggactgcc tgctgacgcc 1759621 atccgacctg cctggggaat gtccgaaact tcatcgggcg ttattttttc tcatgaattt 1759681 acccgggctg gaacaagtga tgatgatcat tttgttgaaa taggctctcc aatccccggc 1759741 ttctctatga gaattgtgaa tgaccataat gaattggttg aagagggtga gatcggccgt 1759801 tttcaagtct cgggtctttc tgttactagc ggttattacc agcggcctga tttgaatgag 1759861 agtgtgttta cagaagacgg ctggtttgaa accggagatc ttggcttttt gcgaaacggg 1759921 cgcttaacca taacaggccg tacgaaagat gcaattatca ttaacggcat taattattac 1759981 agtcatgcaa ttgagtctgc agttgaagaa ttacctgaaa ttgaaacttc ttatactgct 1760041 gcttgcgctg tccgtctggg ccagaattca acagatcagc tggctatctt ctttgttact 1760101 tccgcaaaat taaatgatga gcagatgtct cagcttctta gaaacataca atcccatgtc 1760161 tcacaggtga tcggagtcac cccggaatat ttgctgcctg tacaaaaaga agagattcca 1760221 aaaacggcta tcggaaagat ccagcgcacc cagctaaaaa cttcatttga aaatggagag 1760281 ttcgaccact tgctacataa acccaatcgg atgaacgatg cagtccagga tgaggggata 1760341 cagcaagcag accaggtgaa aagagtaagg gaagaaatac agaagcatct gctcacctgt 1760401 ttgactgagg agctgcacgt ttcccacgat tgggtggagc caaatgcaaa tatccaaagt 1760461 cttggtgtga attctatcaa gatgatgaag ctcattcgat cgatcgagaa aaactatcat 1760521 atcaaactaa cagctagaga gatacatcaa tatcctacaa ttgaacgctt agccagctat 1760581 ctatcagaac atgaagacct cagcagcttg tctgctgaca aaaagggcac ggacacatat 1760641 aaaaccgaac cggaaaggag tcaggcaact tttcagcctc tctctgaggt tcaaaaagga 1760701 ttatggacat tgcaaaaaat gtcacccgaa aaaagtgcat atcacgtacc tctctgtttt 1760761 aaattttcgt cagggcttca ccatgaaaca ttccagcagg ctttcggcct tgtattgaat 1760821 cagcacccaa tcttaaagca cgtcatccaa gagaaagacg gagtgccatt tcttaaaaat 1760881 gagccagcac tttcaattga aatcaagaca gaaaatatct caagtttgaa agagtctgat 1760941 attcctgctt ttcttagaaa gaaagtaaag gaaccgtatg taaaggaaaa cagcccgtta 1761001 gtgcgtgtca tgagcttttc cagatctgaa caagagcatt ttttattagt tgtcattcac 1761061 catttgattt ttgacggagt ttcgtctgtc acatttatac gcagtctgtt tgatacctat 1761121 cagcttcttt taaaaggaca gcagccggaa aaagctgttt ctcctgccat ttatcatgat 1761181 tttgcggcat gggagaaaaa catgcttgcc ggcaaagacg gtgtgaagca ccgtacatat 1761241 tggcagaaac agctatcggg aactttgccg aatcttcagc tgcctaatgt cagcgcaagt 1761301 tcagtcgatt ctcagtttag agaggataca tacaccaggc ggttgtccag cggcttcatg 1761361 aatcaggtca gaacgtttgc gaaagagcat tctgtaaatg tcacgacggt attcttaagc 1761421 tgctatatga tgctgcttgg ccgttacaca ggccaaaaag aacagatcgt cggcatgccg 1761481 gccatggtga ggccggaaga aagatttgat gatgccattg gacattttct caatatgctc 1761541 ccgattcgga gtgagctgaa cccggcagac actttttcta gctttatatc aaaattgcaa 1761601 ttaacgatat tggatgggct tgatcatgca gcatatcctt ttccaaaaat ggtgagggat 1761661 ctgaatattc ctcgcagtca agcaggttca ccggtatttc aaaccgcttt tttctatcag 1761721 aattttcttc aatccggaag ctatcaaagc ttgctgagcc gctatgctga cttcttttct 1761781 gtcgatttcg ttgagtatat tcaccaagag ggcgaatacg aattagtatt tgaactgtgg 1761841 gaaacagaag aaaaaatgga gctgaacatc aagtacaata ctgggctgtt tgatgcggct 1761901 tctatatccg ccatgttcga ccattttgtt tatgtaacag agcaggcgat gttgaatcct 1761961 tctcagcctt taaaagagta ttctttatta cctgaggcag agaagcagat gattctcaaa 1762021 acatggaacg ccacaggaaa aacgtatcca tatataactt ttcatgagtt gtttgagcag 1762081 caggcgaaaa agacgcctga tagagcggct gtcagctatg aaggtcaaac attgacgtat 1762141 cgggagcttg atgagaaaag cacacagctg gccatttatt tgcaggcgca tggagtgggt 1762201 cctgaccgtc tggcggggat ctatgtggat cgatcgctgg acatgctagt gggtttatta 1762261 gcgatcctca aggctggggg agcgtatgtg ccgctagacc cgtcctatcc ggctgaacga 1762321 ttagaataca tgcttgagga cagtgaagtt ttcattacac tgacgacatc ggaattagta 1762381 aatacgttga gttggaacgg tgtcacaaca gcccttttag atcaagattg ggatgaaatt 1762441 gctcaaacag cctctgatcg aaaagtgctt acacgcactg tcacgccaga gaacttggca 1762501 tatgtcattt atacatccgg cagcacagga aagccaaaag gtgtcatgat accacataaa 1762561 gctttgacaa actttctcgt ttcgatgggg gaaacaccag gtcttacggc agaggataaa 1762621 atgcttgctg tcacaaccta ctgttttgat attgcagctc tggaattatt tttgccttta 1762681 ataaagggcg cacactgcta tatttgtcaa acggagcata caaaagacgt tgaaaaactg 1762741 aaacgggaca tccgcgcgat caaaccgaca gtgatgcagg caacccccgc tacgtggaag 1762801 atgctctttt attcaggctg ggaaaatgaa gagagcgtga aaattttatg cggtggcgaa 1762861 gcattgcctg agacattaaa acgatatttc ttagatacgg gcagcgaagc ctggaatatg 1762921 ttcgggccaa ccgaaacaac tatctggtca gcggttcagc gcattaacgt tgaatgctct 1762981 catgccacga taggaaggcc aatcgccaat acacaaatct atattacgga ttctcagctc 1763041 gcgccagtgc cggcaggtgt tccgggtgag ctgtgcattg caggagacgg tgtggcgaag 1763101 ggctactaca aaaaggaaga attaacggat tcgagattca ttgacaaccc ttttgagcct 1763161 gggtctaagc tttatagaac gggagacatg gcccgttggc ttacgggagg gcgaattgaa 1763221 tatataggcc gcatcgataa tcaagtaaaa atccgcggat tccgtattga acttggtgat 1763281 attgaaagca ggcttagtga gcatcccggc attctggaat gcgttgtggt cgcagatatg 1763341 gataacctag ctgcctatta tacagctaaa catgcaaatg cttctctcac agcgagagag 1763401 ctgcgtcatt ttgtgaaaaa cgctttgcct gcctatatgg tgccttctta ttttattcag 1763461 cttgatcata tgccgttaac tccgaacgga aagatagata gaaacagcct taagaatatc 1763521 gatttatcag gggagcagct aaagcaaagg cagacctctc ctaagaacat tcaggatact 1763581 gtttttacca tttggcagga agtgctgaaa acgagtgaca ttgaatggga tgacggattt 1763641 ttcgatgtgg gcggggattc gcttctcgcg gtcactgtgg ctgatcgtat caaacatgaa 1763701 ctatcctgtg agttttctgt cacagacctg tttgagtatt caacgattaa aaatatcagc 1763761 cagtacatca ctgaacagcg aatgggcgat gcaagtgacc atataccgac agacccggca 1763821 gctcatatag aagatcagtc taccgagatg agtgatctcc cggactatta tgacgatagt 1763881 gtggcgatta ttggcatatc gtgtgaattt ccaggggcaa aaaatcatga tgaattttgg 1763941 gagaacctca gagacggcaa ggaaagcatt gcgtttttca ataaagaaga gcttcagcgc 1764001 tttggcattt caaaggagat agcggagaat gccgactatg tccctgctaa agcttcaatt 1764061 gatgggaaag acagatttga tccaagcttc tttcaaatct ctcctaaaga cgctgaattt 1764121 atggaccctc agcttcggat gctgctgact cattcatgga aagcaataga agatgccggt 1764181 tatgctgcga ggcagattcc gcaaaccagt gtttttatgt cggcaagcaa taattcttat 1764241 cgcgcgctgc tgccgtcaga tacaacagag agcctggaga cgccggacgg ctatgtttcg 1764301 tgggtgcttg cacagagcgg gacgattccg acaatgattt ctcataagct cgggctgaga 1764361 gggccaagct attttgtcca tgccaactgc tcatcctctc tgattggatt gcattctgcc 1764421 tataagagcc tcctgtcggg tgaatctgat tatgctttag ttggcggtgc aacgctgcat 1764481 accgagtcaa atatcggata tgtgcatcag cctgggctga acttttcgag tgatggacat 1764541 attaaagctt ttgacgcttc agctgacgga atgataggcg gtgagggcgt tgctgttgta 1764601 ttgctgaaaa aagcagctga tgcagtaaag gacggggatc atatctatgc cttgctgaga 1764661 ggcattggtg taaataacga cggcgctgac aaagtcggct tttatgctcc aagcgttaaa 1764721 ggccaggctg acgtggtcca acaggtcatg aatcaaacga aggtacagcc tgaatccatc 1764781 tgctatgtag aagcacacgg gaccggaacg aagctggggg acccgatcga gctggcggct 1764841 ttaacaaacg tttacaggca atatacaaat aaaacgcaat tttgcggcat tgggtcggtg 1764901 aaaaccaata tcggacattt agatacagcc gccggtcttg cgggctgcat taaggttgtg 1764961 atgagtcttt atcatcaaga gcttgcaccg agtgtcaatt ataaggagcc gaatccaaat 1765021 acagacttag ccagctctcc tttttacgtc gtcgatcaaa agaaaacgtt aagccgtgag 1765081 atcaaaacgc acagggctgc acttagctcg ttcgggcttg gcgggacaaa tacccatgcc 1765141 atttttgaac aattcaaaag ggattcagat aagggaaaga tagacggaac ctgcatcgtc 1765201 ccgatctcgg cgaaaaataa agagaggctg caagagtatg cagaagacat tctggcctat 1765261 ttagaaagaa gagggtttga gaacagccag ctgcctgatt ttgcgtatac ccttcaggtg 1765321 gggcgcgaag cgatggagca tcgcgttgtc tttattgccg atcatgtaaa tgagttaaaa 1765381 cagaggctca cagattttat caatggaaat acagcgattg aaggctgttt tcaaggaagt 1765441 aagcacaatg ccagagaggt ttcatggctg acggaggatg aggacagcgc tgaactcata 1765501 cgtaagtgga tggccaaagg aaaagtaaac aagcttgcag aaatgtggag caagggagcg 1765561 catatagatt ggatgcagct ttacaaggga gagcgcccaa acagaatgag tctgccgact 1765621 tatccatttg caaaggaacg atactggccg tcgcaggatg accgcaaacc ggtggcgcag 1765681 atatccggaa atcagacagg gatcggctct attcatccat tgcttcatca gaatacatct 1765741 gatttttctg aacagaaatt cagttcggtt ttcactggtg acgaattttt cctgagagac 1765801 catgtggtaa gaggaaagcc tgtgcttcct ggtgttgcgt accttgaaat ggcgtacgcg 1765861 gctataaacc aggcggcagg aagtgaaatt ggccaagatg tcagaatcag attgaatcat 1765921 acagtctggg ttcagcctgt tgtggttgac agacattcag ctcaagtgga tatcagtctc 1765981 tttcctgaag aagatggaaa aatcaccttt gacatttaca gtacacagga agacggggac 1766041 gaccctgtta ttcatagtca aggcagtgcg gagctggcat ctgccgccga aacgccagtc 1766101 gcagatctca ctgaaatgtc acgccgttgc ggcaaaggaa agatgtcgcc tgatcaattt 1766161 tacgaagaag gcagaagcag aggaatgttc catggtccgg cctttcaagg aattaagaat 1766221 gtgaatatag gaaacagaga ggttttggcg cagctgcagc ttccagaaat cgtttctgga 1766281 acgaatgaac agtttgtgct gcacccaagt atcatggatt ccgccttgca gacagcaaca 1766341 atatgcatca tgcaggaatt gacggatcaa aagctgattt tgccatttgc gcttgaggag 1766401 cttgaagtga tcaaagggtg ttcttcttct atgtgggctt atgcccgctt aagtgacagc 1766461 gatcactccg gaggggttgt tcagaaagcg gatatcgatg tcattgacga gagtggaacc 1766521 gtatgtgtca ggatcaaagg attttcaacg agagtattag aaggggaggt tcatacttca 1766581 aagccttcaa cacggcacga acgcttaatg cttgaaccgg tgtgggaaaa acagaatgaa 1766641 gaacgagagg acgaagatct ttcgtacacg gagcatatca ttgttctctt cgaaactgaa 1766701 cgaagtgtca cagacagcat tgcctcccac atgaaagatg cccgtgtgat tactctaaac 1766761 gaagctgtag gacatattgc tgaacgttat caatgttaca tgcagaacat ttttgaactc 1766821 ctgcaaagca aggtccgtaa gctttctgca ggccgtatca tcattcaagc gattgttccg 1766881 ctggaaaaag agaagcaatt gtttgccggc gtttccggtc tgtttaaaac agcagaaata 1766941 gagttcagca aactgactgc tcaggtcatc gaaattgaga aacctgaaga gatgatagac 1767001 cttcacctca agctgaaaga cgacagccgg agaccatttg acaaacagat tcgatatgag 1767061 gctggatacc gttttgtgaa aggctggagg gaaatggtgc ttccttcagc tgatacgctt 1767121 cacatgccgt ggagagacga gggtgtttat ctaatcacag gcggagcagg aagcttaggc 1767181 cttctgtttg caaaggaaat tgccaatcga actggccggt ctactattgt gctgacggga 1767241 cgatctgttt taagtgagga taaggaaaac gagctggagg ctcttcgaag catcggagcg 1767301 gaggttgtct atcgagaggc tgatgtaagt gatcagcatg cggttcgtca tcttttggag 1767361 gaaatcaaag aaagatatgg cactctcaat ggaattattc acggtgcagg cagcagtaaa 1767421 gatcgcttca tcattcataa aacgaatgaa gagtttcaag aagtgttgca gccaaaagtg 1767481 agcgggttgt tacatgtaga cgaatgcagc aaggatttcc cattggactt tttcattttc 1767541 ttctcttctg tttcgggatg tttaggaaac gctggacaag ccgattatgc ggcagccaat 1767601 tcgtttatgg atgcatttgc tgaataccgc cgttctcttg cggcatcaaa aaagagattc 1767661 ggctccacca tttccttcaa ttggccgtta tgggaagaag gcggtatgca agtcggcgct 1767721 gaagatgaaa agagaatgct gaaaacgacg ggaatggtcc cgatgccgac agatagtggc 1767781 ttgaaagcat tttatcaagg gatagtatct gataagccgc aagtttttgt gatggaagga 1767841 cagcttcaga aaatgaagca aaaactgctt tccgcaggat cgaaagccaa gcggaacgat 1767901 cagagaaagg cggatcagga tcaaggacaa actagaaaat tggaagcagc cttaatccaa 1767961 atggttggcg caattttgaa agtaaacact gacgatatcg atgtcaacac agagctgagt 1768021 gagtacggat tcgactcagt tacattcact gtctttacaa acaagatcaa cgaaaaattt 1768081 caattggagc taacaccgac catattcttt gaatatggca gcgtccaaag cctggctgaa 1768141 tatgtagttg ctgcgtatca gggcgaatgg aatcaagatg ctactgctaa aggcaaagat 1768201 gaaagaacaa acttagtgca cagtttaagc agcctggagg catcattaag caacatggtc 1768261 agtgcaattt taaaagtaaa tagtgaagat attgatgtca atacagagct gagtgaatac 1768321 ggatttgatt cagttacatt tacggtcttt acaaacaaga tcaacgaaga atttcagttg 1768381 gagctaacgc cgaccatttt ctttgaatat ggaagcctcc acagcctggc tgagtatttg 1768441 accgttgaac atggtgacac cctggttcag gagcgagaaa aaccagaggg gcaggaagag 1768501 ttacagacaa aatcttctga agcgccgaaa atcacatcac gtagaaagcg ccgctttaca 1768561 cagcctatta ttgcaaaagc agaaagaaac aaaaagcagg ctgccgattt tgagccggtt 1768621 gcaattgtcg gcatcagcgg ccggttccct ggcgctatgg atatagacga attttggaaa 1768681 aacctagaag aaggaaaaga cagcatcaca gaagttccaa aagatcgatg ggattggcgg 1768741 gagcattatg gaaacccaga cactgacgtc aataaaaccg acatcaaatg gggtgggttt 1768801 attgatggtg tcgcagagtt tgatccgttg ttttttggta tttcgccgcg agaagctgat 1768861 tatgtagacc ctcagcagcg cttgttaatg acatacgtgt ggaaggcatt ggaagatgcg 1768921 ggttgctcgc cgcaaagcct ttcgggtaca gggaccggta tctttatcgg tacgggaaac 1768981 accggttata aagatctatt ccatagagcg aatcttccaa ttgaaggcca tgctgctaca 1769041 ggtcatatga ttccttcggt aggcccgaat agaatgagtt attttttaaa tattcatggt 1769101 ccgagcgagc cagtagagac ggcttgttcc agttctcttg tagccattca ccgtgctgtg 1769161 actgcgatgc aaaacggtga ttgtgagatg gcgatcgctg gaggcgtgaa tacgatctta 1769221 accgaggagg cgcatattag ctacagcaag gcggggatgc tcagcacaga cggcaggtgt 1769281 aaaaccttct ccgccgatgc gaatggctat gtcagaggcg aaggggtcgg aatggtcatg 1769341 ttgaaaaagc tggaagatgc cgagcgcgac ggaaatcata tttacggcgt tattcggggc 1769401 acggcggaaa atcacggcgg aagagccaat accctgacat cgcctaatcc gaaagcacaa 1769461 gctgatttgt tggtgcgtgc atatcgccaa gcagacatag atccaagcac tgtcacatat 1769521 atcgaagcac atggaacagg gacggaattg ggcgatccga ttgaaataaa tgggctgaaa 1769581 gccgcgttta aggaactatc caatatgaga ggcgagagcc agccggatgt tccggatcac 1769641 cgttgcggca tcggctcagt taaaagcaat atcggtcatt tagagctagc agccggtatt 1769701 tccggtttga tcaaggtgct tttgcaaatg aagcataaaa cgttagtgaa aagcctgcat 1769761 tgcgagacgc ttaatcctta tcttcagctg actgacagtc cgttttacat cgttcaggaa 1769821 aaacaggaat ggaagtctgt cacagatcgt gacggaaacg agcttccgcg ccgtgccgga 1769881 atcagttcgt ttgggattgg cggagtaaac gcgcatattg tgattgaaga atatatgcca 1769941 aaagccaatt cagaacacac ggctacagaa cagccaaacg taattgtgct gtcggctaaa 1770001 aataaaagca ggctgataga tcgtgcttcg caattgcttg aggtgattcg caataaaaaa 1770061 tatactgatc aggatttgca ccgcatcgct tacaccctgc aggtcgggcg cgaagaaatg 1770121 gatgagcgtc tggcgtgtgt tgcggggaca atgcaggagc ttgaagagaa actgcaggcg 1770181 tttgttgacg gtaaggaaga aacagacgaa tttttccggg gacagtctca tcgaaataaa 1770241 gagacccaga ctatttttac agcagatgaa gatatggcgt tggcacttga tgcttggatc 1770301 agaaaaagaa aatacgccaa acttgctgat ttatgggtca aaggggtctc aatccagtgg 1770361 aacacattat acggagagac caaaccgcgc ctgatcagcc tcccttcata tccgtttgcg 1770421 aaggatcact attgggtgcc ggcaaaggaa cattcagaaa gagacaaaaa agaactggtt 1770481 aatgcgattg aagatcgcgc cgcatgcttt ttgacgaaac aatggagttt gagtccaatt 1770541 ggatcagcag tgccggggac aagaactgtt gccatcctgt gctgtcaaga gacagcagat 1770601 ttagcagcag aagtgtcttc gtattttccg aatcatctct taatagatgt gagccggata 1770661 gaaaatgatc agtcagacat tgattggaaa gagtttgacg gcctagtgga tgtcatcgga 1770721 tgcggttggg atgatgaggg ccggctggat tggattgaat gggtgcaaag actggttgaa 1770781 ttcgggcata aagaggggct caggctgctt tgtgtgacga aggggctcga atcgtttcaa 1770841 aacacatctg tccggatggc tggcgcctca cgggctgggt tgtatcgaat gctccaatgc 1770901 gagtacagcc atcttatatc aaggcatatg gatgctgagg aggttactga tcatcgccgt 1770961 ctcgcgaagt tgatcgctga tgagttttat tccgattctt atgatgcgga ggtttgctac 1771021 agggatggtt tacggtatca agcttttcta aaagctcatc cggaaacagg taaggccacg 1771081 gaacagagcg cggtcttccc gaaagatcat gtacttctca ttacaggcgg cacacgaggc 1771141 atcggactat tatgcgcccg tcattttgca gagtgctatg gagtgaaaaa actggtgctg 1771201 accggacgag aacagcttcc tccgcgagag gagtgggctc gttttaagac atcaaacaca 1771261 tcattggcag agaaaatcca ggcagtgcgg gagctggaag cgaagggtgt acaggtggag 1771321 atgctgtcgc tgacgttatc tgatgatgct caggttgagc aaacgctgca acatatcaag 1771381 cgaacattag gaccgattgg cggtgtcatt cattgtgcag gtctgacgga tatggatacg 1771441 ctggcattta tccgaaaaac ttcggatgat atccagcggg tgctggaacc taaggtgtca 1771501 ggtcttacaa cgttatatcg ccatgtgtgt aacgagcctt tacagttttt tgtcttattt 1771561 tcttctgttt cagccattat tccggagctt tcggcgggac aagctgacta tgcgatggcc 1771621 aatagctata tggattattt tgcagaagca catcagaaac atgcgccgat catcagtgtt 1771681 cagtggccga actggaaaga aaccggtatg ggtgaagtga caaatcaagc gtatcgggac 1771741 agcggcttgt tgagcattac gaattcagaa ggcttacgtt ttctagatca aattgtatcg 1771801 aaaaagttcg gaccggttgt tctccctgca atggcgaatc aaacaaactg ggagccggaa 1771861 ctgctgatga agaggaggaa accgcatgag ggcggtttgc aggaagctgc tttacagagc 1771921 ccgccagcca gagacattga agaggccgat gaagtttcca aatgtgatgg attattatct 1771981 gaaacacagt cctggcttat tgatctgttt accgaagagc tgagaataga tcgtgaagac 1772041 ttcgagattg acgggttgtt tcaggattat ggcgtggatt cgatcatttt ggcacaggtg 1772101 ctccagcgta taaaccgcaa attagaggca gcgctcgatc catcgattct atatgaatac 1772161 ccgacaattc aaaggttcgc agattggctg atcggttctt attccgaaag gctgtccgct 1772221 ttattcggag gcaggatatc ggatgcatca gcacctttgg agaacaaaat agaggcggag 1772281 gcatctgttc ctgggaagga tcgagctctt acacctcaga ttcaggcgcc agcgattttg 1772341 tcaccggact ctcatgcaga aggtattgcc gttgtcggac tctcttgccg attccctggg 1772401 gcagagacat tggagtcata ttggtcgtta ctatccgagg ggcgttcgtc aatcggcccg 1772461 attccggcag agcgttgggg ctgtaagacg ccatattatg ccggcgtgat tgatggcgtc 1772521 agctattttg atcctgattt ctttttgctt cacgaagaag acgtaagggc gatggatccg 1772581 caagcactgc tcgtgttgga agagtgtctg aagctcttgt atcacgccgg ttatacacct 1772641 gaggaaataa agggcaagcc cgtcggtgtt tatatcggag gcagaagcca gcacaaacct 1772701 gatgaagaca gccttgatca tgccaagaat ccgatcgtga cagtcggcca aaattattta 1772761 gccgctaatc tttcacaatt ttttgatgtc cgcggtccaa gtgttgtagt tgacactgca 1772821 tgctcgtcag ctttggtcgg catgaatatg gccattcagg cgctgcgtgg cggagatatt 1772881 caatccgcca tagtcggcgg tgtcagcttg ctgagctcag atgcgtctca caggctgttt 1772941 gaccggcgcg gcattttaag caagcattca tccttccatg tgtttgatga gcgtgctgac 1773001 ggagttgtgt taggtgaagg cgtcggaatg gtcatgctaa aaaccgtaaa acaggcactg 1773061 gaagacggag atatcatata tgctgtcgtc aaagcggcct cggtcaataa cgacggaaga 1773121 acggcgggac ctgcaacacc taatcttgag gcacaaaagg aagtcatgaa agatgcgctt 1773181 ttcaaaagcg gaaaaaaacc agaggacatc agctaccttg aggcaaacgg gtcaggttca 1773241 atcgtaaccg atctccttga gctaaaagcg atccaatcag tgtaccgttc tgggcactca 1773301 tcgcctcttt ctcttggctc aatcaagccg aacatcgggc atccgctatg tgctgaaggg 1773361 atcgccagct tcattaaggt tgtgctgatg ctgaaagagc gccgctttgt cccattttta 1773421 tcaggtgaaa aagagatggc gcatttcgat caacagaaag cgaacatcac gttcagccga 1773481 gccctggaaa aatggacaga ttcgcagcct actgcggcta ttaactgctt tgccgatggg 1773541 gggacgaatg cccatgtcat cgtagaggcg tgggaaaaag atgaaaaaca cgccatcaag 1773601 cgcagtccaa tatcgcctcc tcaattaaag aaacgaatgc tttcgccagg cgagccaaag 1773661 ctggaagcgg agacttcaaa aatgactgcg gcaaacatat gggatactta tgaggtggag 1773721 gtctaacgtg aaaaagataa cgaaacaact cacattatcg ttaaaaaatc cgtttattta 1773781 tcaccatgtg gtttacggac aaaatgtcct gccgggattg gcttatatcg atataatcta 1773841 ccagatattc agagaacacg gtttctcctg ctcagagctt cagctgcgga atttatccat 1773901 ctatcagcca ttgacggcgg aacaggatgc agtaattgtt ttgaatatcc aatgcgcgga 1773961 gaaaaaagaa ggacagtggc aaatcacagc caagggaatt gaaaaacgtg atgggaaaga 1774021 agcttcagaa gaaaagctct atatgaaggc tgacatgcac gcagactccc cagccatatt 1774081 tgaagaaaca ctggatctca gtcaaatcaa agcatctgca cagaacgttg ttcagcttga 1774141 tgatgtatat gaacaatgca gacgtcagga attggtgcac agcgaatata tgaaagcaaa 1774201 aggctgcatc tatgaagagg aagacggcgt ccttcttgag ctttctctcg gttcggaggc 1774261 catgcttcac gcagaaggct ttatgtttca cccgactctc atagacggga gcggggtggg 1774321 tgccaatcat ttgctcacat ctttgcttaa aggagaacag aggctgtatt tgcctctgtt 1774381 ctatgaatcc ttttccgctt ctgcactttt gcaaacggat tgcatgacaa gaattaagcg 1774441 ctcctccgtc cggcgggaaa aagagctgat ttatgtaaca cttgaatttt ttaatgcgtc 1774501 gggagaaaaa gtggctgagt tgaaaaactt tacaagcaaa ttggtgcgag aagcggagct 1774561 gattagcgga aaacatcaag atgcacagga gacacagatg acaagagcgg acactgctga 1774621 gcgtgataaa cctgctgaca tggtatcttc tcccgttaat tcctatagtg aggctgaaca 1774681 gttcgtaagc caattaatcg cagagaaaat caataagccg gtagaacaag ttgaaaaaca 1774741 ggtcggttat taccaaatgg gactgaattc atcgggcttg cttgaggtgg tagaaacgat 1774801 cagtgataag atcggtgaga gcctttcgcc gactcttctg tttgagcata ccaccatagc 1774861 ggaactgtca gcgtttcttg ccgaggaata tgctgagcat tttagtgccg ctggttctct 1774921 tggccagaat gaaagagcac gcgtttccga cagcataaac gaccataaga ctgttgaagg 1774981 ctctcgtcct gcacctattg aggcagcagg cgatattgcg attatcggct tggcgggcag 1775041 gtatccgaag gcagccaata ttcatgaatt ttggaacaat ctgaaagagg gtaaggactg 1775101 cgttagtgag attcctgagt cgcgctggga ttggcagcga cttgaaggaa tcacatctcc 1775161 ttcgggtaag gacatttcca aatggggagg atttattgat gatcccgact gcttcgatcc 1775221 ccaatttttc agaatcacgc caagagaagc ggagacaatg gaccctcaag agcggctgtt 1775281 tttagaaaca tgctgggaaa cgattgaaga tgcgggctat acgccaaaga cgttggccaa 1775341 gcctaaagga cgaaataaaa ggcagcatgt aggagttttt gcaggcgtca tgcacaagga 1775401 ttatacatta gtcggagctg aagaagcatc agcagaaaat gtgtttcctc tttcgctcaa 1775461 ctatgcgcaa atcgccaacc gtgtttctta cttttgtaat ttccacggtc cgagtatggc 1775521 tgtcgatacg gtatgttcat cctctttgac cgcagtgcac ttggcgttgg aaagcatacg 1775581 tcacggtgag tgcgatgttg cgttagcagg cggagtgaac ctgtctttgc acccgaataa 1775641 atatatgaca tacggggtct gggatatgtt ttccactgac ggacactgcc gtacgtttgg 1775701 aaaggatgga gacggttatg tgcctgcaga gggtataggc gcggttttat taaagccttt 1775761 gcgccaggca gaggaagacg gagatcgcat ttatgcagtt attaaaggaa gtgctgtgaa 1775821 tcatgtgggc actgtaagcg gcatttcagt gccgagccct gtttcccaag ctgatctgat 1775881 tgagacatgc ttggagaaaa cgggaatcga tccgcggacg atcagttatg tggaagccca 1775941 tggaaccggc acgtccttag gagatccgat cgaaatacag ggattagtga aagcgttccg 1776001 ccaatatacg caggatcggc agttctgttc aatcggttct gtaaagtcaa acattgggca 1776061 cgccgaatcc gccgcgggga tcagcggttt aagcaaggtt gctcttcagc ttcaccatca 1776121 aaaacttgtg ccttctttgc attcggaaga actgaatccg tacgttgatt ttgaaaagtc 1776181 tccattttat gtacagcatg aaacagaaac gtggaagcag cctgttatca aggagaatgg 1776241 ggaagacgtc ccttatccgc gacgggcggg gatcagttct tttggcgcaa caggttcaaa 1776301 cgcacatatt atccttgagg aacatattcc tcaagcagcg gagcaggacg tttctttgtc 1776361 ctcagattct gacatatccg cagttattcc gctttctgcc cgtaatcaag aacgtctccg 1776421 tgtatatgca aaacgtctct tggattttct tcatgatggg attcagatta gagatttggc 1776481 gtatacattg caggtaggcc gtgaaccgat ggaagaacgg gtttctttct tagcatccgg 1776541 aattcaagaa ttgagcgacc aattgaaggc ttttatagaa ggacgaaaag ccattcagca 1776601 ttgctggaag ggccgcgtgt caagaggaag cgaaccatcg cgtcccgccg aatcggtaca 1776661 taaattgctg gagcaaagaa aactcgatca gattgcggag cagtgggcga acggatctgg 1776721 tgttgactgg aagctgcttt acgagggaag caaaccaaag cggatcagcc tgccgactta 1776781 cccatttgag agggtgcgtt attgggtgcc gaaagcggag aaaaagactg atcgttcaaa 1776841 acaggagcgg cacatcctgc atcctcttct gcatcaaaat gtgtccgaca tatcgggtgt 1776901 ccgcttccgt tcagcgttta caggacgtga atttttcttg aaggatcatg tcataaaggg 1776961 cgaacacgtt ttacctggcg cagctttatt ggagatggtt cgggcagctg tggaaagggc 1777021 agctgcggat cagttcccga caggattccg gctccggaat atcgtctggg tccggccgtt 1777081 cgccgtcacg gaacagcaga aagatataga tgtacgtcta tatcctgagg aaaatggtga 1777141 gattacattt gaaatctgcc gggaccctga aagcgcagag gagtcgccga ttgtatatgg 1777201 gcaagggagt gcagtgcttt gtgaggctgg tgaaaatccg gttatcaaca ttgaagaatt 1777261 gaaggcaagc tataatggcc ggacgctgtc accttttgat tgctacgagg cttatacaga 1777321 aatgggtatt cattatggtg acagccacag agcgatcgac agcctatatg ccggcgaaaa 1777381 cggagttcta gtgaaattga cgatgcctcc tgtaatctct gatacagaag accattatat 1777441 tctgcatccg agcatgatag attcggcatt tcaagcatct atcggtttga ggctgggagg 1777501 agctacgagt ttagaagaca gaaaggcaat gctgcctttt gccatacagg atgtccgaat 1777561 cttcaaaggc tgcgaggcat ctatgtgggc gcggatcaca tatagcgagg gcagtacagc 1777621 tggggatcgt atgcagaagc ttgatatcga tttatgcaat gaagagggcc aggtttgcgt 1777681 gcgattgacg agctattctg caagagtgtt agaaacagat caagaaggtc cttctgaagc 1777741 gaatgacacg ctattgttcg aacatatttg ggaagaacgt gctgcagaga ggcaagagct 1777801 catagagtac gacacgtata aagtcgttgt ctgtgatgtt ggagaacaaa tggaaagcct 1777861 ccaaaatcat cttgactgta cagttctgca gcatgataca gagacaattg atgaacggtt 1777921 tgaaggttat gccatacagt tatttgaaga aatcaaacag ctaatgcact caaaaacagg 1777981 aggacataca ttcattcaag tggcggtgcc tgcgttggac gagcctcagc tattaagcgg 1778041 cttaactgga ttgctcaaaa cggctgaact ggaaaatcca aaactgacag gacagttgat 1778101 cgaaatagaa accgggatgt cagctggtga gctattcgaa atattggagg aaaacagacg 1778161 ctatccgcgt gacacgcata tccgccactg gcaagggaag cgatttgtaa gcaagtggaa 1778221 agaagtgtct ggtgagcacc taagtgctga catgccatgg aaggataaag gcgtgtatct 1778281 gatcacaggc ggtgcgggcg gtctgggatt catctttgca actgaaatcg caaaccaaac 1778341 gaatgatgcg gttgtgatcc tgacaggacg ctctccgctt gatgaaagga agaagaagaa 1778401 gcttaaagcc ttacagaaac ttggcatcca agcgatttac agacaagctg atctggctga 1778461 caaacaaacg gttgatgcct tattaaaaga aacccaaaac gtttacggag acttagatgg 1778521 catcattcat agcgccggtt taataaaaga taatttcatt atgaagaaaa agaaagaaga 1778581 ggttcaaacc gttcttgctc caaaggtagc aggactgatt caccttgacg aagcaacgaa 1778641 agatattccg ctcgatttct ttatcctttt ttcctcaggt gccggagcag taggaagcgc 1778701 gggacaggct gattacgcaa tggccaatgc atttatgaat gcattcagcg aatatcgaaa 1778761 tggccaagca gagctgcata agcgttacgg aaaaactctt tcagtgtgct ggccgctgtg 1778821 gaaagacggg ggcatgcaaa ttgatgcgga aactgcaagg atgctgaaaa gagaaacagg 1778881 catggtggcc atggaaacag atcgtgggat tcaggcgcta tatcatggct ggacgtcagg 1778941 aaagccgcaa gtgttagttg cttccggtgt tactgatcgg attcgtgcat ttttacatga 1779001 aacgggacat ggcaaaggcc aatctcacaa tatcaaaaaa agcagtctca atcaggaggc 1779061 agaaaaagca gacatgatcg gggaaattga tgaagagata ctaagagaaa aagcggagaa 1779121 ctattttaaa caggtgcttt cttcggtgat taagctgcca gctggccaga ttgatgctga 1779181 agctcctctc gaggattacg ggatcgattc tatcatgatc atgcatgtaa cgggtcaatt 1779241 agaaaaagta ttcggatctt tgtccaagac gctgttcttt gaataccagg atattcggtc 1779301 attaacccgg tattttattg attcccgcag agaaaaactg ctggacatct tgggatttga 1779361 aacgggaaaa ccttctgttg aaagaaaatc agaacctgaa aaacaagaaa tcccagttat 1779421 cccaagaaag tctggatttc ttcctttgca agataaagag cagaagcagg taagagagaa 1779481 ggaaacggaa gaaattgcga tcatcggtat ctcaggtcgc tatccgcagg cagacaacat 1779541 tgatgaatta tgggaaaaac tgagggacgg gcgagactgt attacggaaa ttcctgcaga 1779601 ccgctgggat cacagtcttt attatgacga agataaagac aagcctggaa aaacctacag 1779661 caagtggggc ggcttcatga aggatgtaga caagtttgac ccgcagtttt tccatatttc 1779721 gccgcgtgag gcaaaattaa tggacccgca agagcgttta tttttgcagt gcgtgtatga 1779781 aacgatggaa gacgcaggct atacaagaga gcacctcggc cgtaagcgtg atgctgagct 1779841 tggcggaagc gtcggtgttt acgtcggtgt catgtacgaa gaatatcagc tgtacggggc 1779901 acaagagcag gtgcggggaa ggtctctggc tttaacggga aatccatcat ccatcgcgaa 1779961 ccgggtatct tattattttg attttcacgg accgagtatt gctttagaca ccatgtgttc 1780021 ttcttcttta acggctatcc acttggcctg ccaaagcctg cagcgcggag aatgtgaggc 1780081 ggcattcgcg ggcggcgtga atgtgtcaat ccatccaaat aaatatttga tgctcgggca 1780141 gaacaaattt atgtccagca aaggccgatg tgaaagcttc ggacagggcg gagacggcta 1780201 tgtgccgggg gaaggcgttg gagcagtgct tttgaagcca ttgtctaaag cagttgaaga 1780261 tggtgatcac atttatggaa tcattaaggg gacagccatc aaccacgggg gaaaaacaaa 1780321 cgggtactca gtgcccaatc cgaatgccca agcagatgtc atcaaaaagg cgtttgtgga 1780381 agcgaaggtt gatccgcgga cagtcagtta catcgaagcc cacggcacgg gaacctctct 1780441 cggtgatcct attgaaatca cagggctgtc caaagtgttt acgcaagaaa ccgatgacaa 1780501 acaattttgt gcaatagggt cagccaaatc aaatatcggg cactgtgaga gtgcggcagg 1780561 tattgcagga gtaacgaagg tattgctcca aatgaaatac aggcagcttg cgccttccct 1780621 gcattcaaac gtgctgaacc cgaatattga tttccttaac tcgccgttta aagtacagca 1780681 agagctagaa gagtggaaga ggccgatcat cagtgtcaat ggcaaagaca tcgaattacc 1780741 gagaatcgca ggagtctctt catttggtgc cgggggtgtg aacgcccata ttttaataga 1780801 agagtatgct ccggaacctg tggaggaacg tttaccagcg aggaaacagc cggctgtcat 1780861 tgtgctctca gcaaaaaatg aggaaagact tcagaaacgc gcggagcgat tgctgcatgc 1780921 cattcgtgaa caaacatatg ttgaagcaga tttacaccga attgcctata cgctgcaagt 1780981 cggccgggaa gcgatgaaag aacggctggc gttcgttgcg gaaacgatgc aagagcttga 1781041 agaaaagctg tatgaatgta tctccggaac agaaaatcgt gaatatgtct atcgcggaca 1781101 agtaaagagc aacaaagaag ccattgctgc ttttgctgct gatgaggata tgtcaaaaac 1781161 aattgaggca tggctgcaaa aaggaaaata tgcgaaggtt ttagacctgt gggtaagagg 1781221 tttgcgaatc gactggagca cgctatatca ggatcaaaaa ccgcggcgca tcagtttacc 1781281 tgcctatcct ttcgcaagag atcgctattg gatagacgta aatgcaaagg ctgaggaaaa 1781341 aagaacggag gagccattcg ctccagtaca gcccgttatt ccgaagccgt ctgtagacag 1781401 agaagccagt ggcaagcctg ccaatattac gttacagcct ttaatgacca atcaggatcg 1781461 tttagagcgt gttccatcag atacagaaac agagacgatc acggcggaag ccttgtgcga 1781521 tgaactgaca gcgggcttag cggaagtgct gtacatggac caaaacgaga ttgatccaga 1781581 cgaagcattc atagatatcg gtatggactc gattaccggg ctcgaatgga taaaagcaat 1781641 aaataaacag tatggcacat cactaaatgt cacaaaggta tatgattatc cgacaacacg 1781701 tgatttcgct gtttacttag cacacgagtt aagcacacaa gctggggaga aaaaacaaac 1781761 ggagacgtac acgccgatca gacaaaaaac agtggtacct gctgctaaac cggctaatat 1781821 atctctgcag ccgttagaac atcatcagcc agtgcaagag gaagctgaag aaacgattca 1781881 atatgcagcg gcagaaatat ctgcatcaag acaatatact gtagcaattg aaacgctgca 1781941 tgaaaacttg agggaaagca tagcagacgt gttatacatg gagccatacg aggtggatat 1782001 tgacgaagcg ttcatagata tcggaatgga ctcgattacc ggactcgaat ggataaaagc 1782061 ggtgaacaag caatacggaa cgtcttttac ggtaaccaga gtatatgatt atccaacgat 1782121 acgtgatttt gccgaaatgc taaagtccga gcttggaact catcttgata gaaagataga 1782181 gcatactgac tctttcgaag cagcccagca aaagccagca gcatcatctc atccaaagcc 1782241 ggcagaacgg ccactacagc ctgttcaaca tccaataaag aaagaacatg agaagaaaac 1782301 ggttcctgtt cttcaagacc gcccggagga tgcgatagcg attgtcggga tgtcgggaag 1782361 atacccgggc gctcgtaatg taagagagta ctgggataac ctggttcatg cgagaaatgc 1782421 cattcgggac attccaacat cacggtggga tgttgacaaa tactatgatc ctgtcctcaa 1782481 caaaaaaggg aaagtctatt gcaaatcaat ggggatgctt gatgatattg aacattttga 1782541 tccgttgttt tttaatattc cgccgtcaga agctgaactg atggacccgc agcatcgaat 1782601 ctttttgcag gaaggctata aagcctttga ggacgctggg tacaacgccc gaactttaaa 1782661 tgagaaaaaa tgcggtgtat atctcggcat tatgagcaat gaatacgggg tcatgctgaa 1782721 tcggcagtca agagcaaatg ccaccggaaa cagctttgcg atcgcagcgg cgcgtattcc 1782781 gtattttcta aatttaaaag ggccagcgat tcctattgat accgcatgtt catcttcatt 1782841 ggtcggcact catttagcgc gccaggcact tataaacaaa gaaattgata tggcgctggt 1782901 cggcggggtc agcttatacc tgacgccgga atcttacatg agtatgtgtg aggccggcat 1782961 gctttcacct gatggacaat gtaaagcatt tgacaatggc gcgaatggtt ttgtgcccgg 1783021 cgagggtgcg ggtgcgctgg tattgaaaag gctgaaagat gcggaagcgg accgtgacca 1783081 tatttatggc atcatcattg gctcgggtat taatcaggac gggaaaacaa acggaatcac 1783141 ggcaccgagt gcgaaaagcc aaatggatct ggaaagagac atatatgaaa catacggcat 1783201 acatcctgag agtatcagtt atgtcgagat gcacggcaca ggaacaaaac aaggcgatcc 1783261 aattgaatta gaagctctgt ccaccgtatt tcaagaaaaa acagacaaaa agcagttttg 1783321 cgcaatcggt tccgtcaaaa gcaatattgg ccatacatcc gcggcggcag gagtagccgg 1783381 ggttcaaaaa gtgttattgt gcatgaatca taaaacactt gtgccgacat tgaacttcac 1783441 gacaccgaat gagcattttg aatttgagca ttctccttta tacgtaaata cggagcttaa 1783501 gccttgggaa acggctgatg gaaaaccgcg gagagcatgt gtgagctcct tcggatatag 1783561 cggaacgaat gcccatattg tgatagagga atatcagcct gaaaagagga acgatcgatt 1783621 aacaaagcag caccgctcag cattatttgt actctcagcg aaaaaagaga agcaattgaa 1783681 ggcctatgcg gaagcaatga aagatttcgt aacttccaat gaagatatcg atctggagga 1783741 tatggcatac acacttcaga cgggccggga agcaatggat tatcgcatgg cgtttttggc 1783801 ggattcgaga gaaatgctga tcaaagcttt agatgattat ttggctgaaa tgccgaacgg 1783861 cagcatattt gctgctcacg tgaaaacgaa gaagagcgaa atcaagctgt ttgaaacgga 1783921 tcatgatgcc aaagcattgc tgcaaacatg gatagagaaa aaaaggctgg agaaagtagc 1783981 agagctatgg gtgaaagggc tgcagataga ttggaacaag ctttatgggg aatacacgcc 1784041 tcgccgaatc agcctgcctg cttatccgtt cgcggaagag tattactggc tgccaactca 1784101 agaaggcgaa cccgaaacca ttgctacagc aatgcctcaa ttcgaactga tgccaaagcg 1784161 ctgctttctg cgtaaacagt ggcagccttg tccgattgaa ccggcagaaa tgacgaatca 1784221 aaccgtcgcc attttggcaa atgaggagac aatggcatta gcggaagagc tttcggcgta 1784281 tttctcgaca taccgtatat ttgacagcca agagctggat cgggtatctg ctgctgacta 1784341 tgaacacgtt gctggagcaa tcgatctgat cgggtgcgga acgagccatg agcattctat 1784401 gggctggata aactggctcc aaaagctgat cgagcaagga cgtgcaagca agcatcattt 1784461 gacggtcttg ggtgtaacaa aggggctgga ggcctacgca aatgagggtg ttcttttgtc 1784521 tggtgcttca cgggccggtt tataccgcat gcttcaaagt gagtacagcc atcttacttc 1784581 aagacatgca gatatggaat gcgaagcctc tcatgaggag ctggccagac tgattgcagt 1784641 tgaatattat gccaagagca cagaatcaga agtctgttat cgaaacggac agcgatatcg 1784701 cgcatatttg acagagcagc cagcagaagc cgctctaagt cataagcaag tatcgttttc 1784761 aacagacaaa gtcctgctta ttacaggcgg gacaagaggt ctcggcttgc tgtgtgcgcg 1784821 gcattttgtg aaaacatacg gcgttaagcg gctggtcctt atcggccgtg aagagcttcc 1784881 gccgcgtgac cagtggaatt cggtaaaaat ttcctcgctt gccgagaaaa taaaagccgt 1784941 tcaagagcta gaagacatgg gtgcgcaagt tcaggtgctg tctctggatc tcacagacag 1785001 ggttgctgtc gaacagagcc tgaagacaat acacgaaaca atgggggcga ttggcggagt 1785061 catccattgt gccgggatgg tgaacaaaca aaacccggct tttatcagaa aatcactaga 1785121 agagatcgga caggtgcttg aaccgaaagt cgaaggtctg caaacgttgt ttgacctgct 1785181 tcaagatgaa ccattggcgt ttttcacctt gttttcatca gtatcagcgg ccatccctgc 1785241 actagcagca ggacaagctg attacgcgat ggcaaatgct tttatggatt attttgcgga 1785301 ggctcatcaa gataaatgtc ccattgtaag cattcagtgg cctaactgga aggagaccgg 1785361 tttaggcgag gttcgaagca aagctttaga acaaactgga ttgatcagtt tgacaaacga 1785421 cgagggatta cagctgcttg accagattct atcagacaga cagtatgctg tcgtgctgcc 1785481 ggcagtacca gatacaaacg tttggaagcc ggataagctg atgcagccgt cattgcctgt 1785541 cgaagctctc tcgcatcctg agacgaaaga gcaaaccagc actcgcaacc tgttccctga 1785601 aacagtcgac tggctcgtaa ctcttttttc agatgaactg aaaatagctg cagaagactt 1785661 tgaaacggat gaacctttcc aagaatacgg aatcgactcg attatattgg cccagctggt 1785721 acagcagatg aaccaacaat taaatggaga tattgatccg tcaatcttgt ttgaataccc 1785781 gacaatagaa tcctttgcac actggctcat ttcgaaatat gacatatcag ctgttttaca 1785841 gccatctgtt cctgagaaac agacacctct caagccgcaa tcagcaatga aacagaagct 1785901 ggtgccagaa cagcggccgc aacagataag ccatgaaaaa acggcacttc ttgctgagga 1785961 catcgctatc atcggtctta gttgcaggtt cccgggagca gaaaccctag aggaatactg 1786021 ggatttaata cgtgatggac ggtctgcgat tgcgcctgtt ccgcctgaac gattcgggaa 1786081 ctccagctcg aattacgcgg gcctcattga tgaaatgaac cgatttgatc atgatttctt 1786141 catgatgtcc gaaagcgatg tcagagcgat ggaccctcaa gctttggctg tattggagga 1786201 aagcttgaag ctatggtatc acgcgggtta tacagagaaa gaagtgaaag gcatgagggc 1786261 tggtgtttat ataggaggcc gcagccagca caagcctgat ccggccagtc tttcaaaagc 1786321 aaaaaatccg atagtcgctg gtggacaaaa ctatttagcg gctaacatct cacaattttt 1786381 tgacttgaag ggaccgagta ttgtcctgga taccgcttgt tcctctgcac tggtggggct 1786441 gaatatggcc attcaggctc tgcgaagcgg agatattgag gcagcggttg taggcggcgt 1786501 cagtttgctt gatgctgatg cgcatcgaat gtttcatgag cgcggacttt tatgtgacaa 1786561 accgtcattc catatttttg ataagcgggc agacggtgtc attttaggag aaggcgtggg 1786621 catggttctc gtcaaaaccg tcaaccaagc ggttgaagac ggagattcca tatatgcagt 1786681 cattaaagcc gctgcgatta ataatgacgg aagaacggca ggcccatcat ctccgaatct 1786741 cgaggcacaa aaggacgtca tgctgtcagc gcttgaaaaa agcggcaaaa agactgaaga 1786801 gatcagctat ctcgaagcga acggatcggg gtcggcagta acagatttac ttgaattaaa 1786861 ggcaatccag tccatttacc gttctgaatc aaaggctccg ttagggctgg gatcggtgaa 1786921 acctaacatc ggccatccat tatgtgcaga gggaattgcg agcctgatta aagtagcttt 1786981 aatgctgaag catagacaat tggttccgtt cctgtcaggt aatgaaaata tgccgtattt 1787041 tgatatagaa aaaacagatt tgtatttcag cagatcgcaa gccgagtgga aggagacaac 1787101 gccggctgcg gcaattaatt gttttgcaga tggcggaacg aacgcccatc tcattataga 1787161 aggttggaga gactcggctg agcgtccaat tagaagaaaa cctctgcctt tgccggaatt 1787221 aaataggcag cccgttttaa tcaaaccatc agctcaaaac gtgcagaaaa aagtgcattc 1787281 agacacaggg gcttctaaag atatgttttg gaaaactttc aaataagaga ggagtgggaa 1787341 aatgataact gaacaactgc acatttcatt aaataatcca atcatgtcca accacaaggt 1787401 atatggacaa gcgttattac ccggccttgc ttatatagat ttaatctacc aagtattcca 1787461 ggaacatggt tatgcatacc aagagcttga attaaaaaac ctaaccattt tttacccttt 1787521 gatcgcagat gagtcatatg acattgccct gaccattcac gtgtctgaaa gaaaggaagg 1787581 gacatggtcc atcatcatcg acggacaaaa acagcatgga gaatcactat ctgacaagag 1787641 acaatatgtg actgctgaca tgcatcgtaa agagcaaacc gcttttgccg aatcaataga 1787701 ccttaatcag tggaaaagta cagctgacag gattctgaat ttagatgaaa tctatgaaca 1787761 atgccgatct caagagttag tgcataccgg catgatgaag gcggaaggac agatttatga 1787821 agccaaagag ggggctgtaa ttgatttagc agtcggacag gaagcattgc gtcattctga 1787881 tgcttttctg tttcatccga cgcttattga cggcagcggc ataggttcaa gctgcctgat 1787941 ctcagatcaa acgatgtacc tgccattgta ttatgaatcg ttttctgctt cagaacgatt 1788001 gcaaaaagga tgtacagcac ggatcctctc ctcatctgtg cgccaaaaga aagaactcac 1788061 ttatatgacg attgaatatt ttaattcagc aggacaaaaa gtggccgagc tgaaacaatt 1788121 tgcaggcaag tctgtacgga atatgtcagc ctttcattct gcaaaagaaa ttcaagaaga 1788181 aagagctgct gtctctcaga acatcagtcg ggactatccc gcatttgaaa tgtatttgcg 1788241 tcagctgctt gctaagcagc ttgaaaggcc ggcagaacaa atggatatcc acgctgggta 1788301 ctatgagctt ggtctggatt cttcgtcatt gcttaccgtg gttcaggaaa ttggagataa 1788361 ggttggggcg gatcttgctc cgacactgct gtttgaattt acaacaattg cagaactagc 1788421 tgctcatctt gctgatcact attcaattgg agaggcggac gatgctgtcc gccaatctcc 1788481 ttcaccaatt gatggtgtta cctcttcacc agagatcggg gaggacatag ccattatcgg 1788541 aatggcggga cgctatccta aggcgaaaaa tatacaggaa ttttgggaac agcttaaagc 1788601 gggtaccgac tgcatcacag agattccaaa ctcacgctgg gaatggaaag aaagcgatgg 1788661 actggattca cctgcaggca agccgctctc gaaatggggc ggctttatcg aggaggctga 1788721 ttgctttgat cctcaatttt tcagaatctc tccgcgtgaa gcggaaatga tggaccctca 1788781 ggaacgctta tttttagaga cgtgctggga agctattgaa gatgcgggtt atacaccaga 1788841 gacaattgct tcaccgcagg gagaaaataa aagacagcat gtcggtgtgt ttgccggcgt 1788901 tatgcataag gactattctc ttataggagc tgaagctcta tcagaacaca atccatttcc 1788961 tttatcgctg aattatgcgc aaatcgccaa cagggtctct tactattgta atttccacgg 1789021 cccaagcatg gcggtggaca cggtctgctc ttcctcatta actgcggttc atctggcaat 1789081 agagagcatc cggaatggag aatgcgaggc cgcgcttgcc ggaggcgtca atttgtcact 1789141 gcatccggct aaatatatca gctatggcag tgtagggatg cactcaagtg acggctattg 1789201 ccatactttc ggcaaaggcg gggatggcta cgtatctgga gaaggtgtcg gcacagtatt 1789261 gctaaaaccg ctgcgaaaag ctgaacagga cggtgaccga atctatgctg tcatcaaagg 1789321 cagtgcgata aatcatgtag gaaaagtaag cggaattaca gtaccgagcc cggtagctca 1789381 agctgatgta atcgaagcat gtctagaaaa aacaggaatt gatccgcgca ccatcagcta 1789441 tgttgaagcc catggcactg gcacctcatt gggagatccg attgaagtac aggggttagt 1789501 aaaagctttc agccgcaata cgcaggacaa gcaattctgt tcaatcggtt ctgtgaaatc 1789561 aaatattggc catgctgaag ctgcagccgg cattagcggc ttaacgaaga ctgtcctgca 1789621 gctgcatcat aaaaccttgg tgccgtcatt acattcagaa gagctgaatc cttatttgaa 1789681 gcttgatcaa accccatttt ttgtccagca tgaaacaaag gaatgggagc agccatcttt 1789741 tacagaaaac ggggtggacg tcacatatcc ccgccgtgcc ggtttaagtt cgtttggcgc 1789801 ttcaggatca aatgcgcatc ttattttgga agaatatatt ccggcagaga gccattcaga 1789861 gacgatttta acgaaaaatg aagaaatagt gatacctttg tctgcgagaa acaaagatcg 1789921 tctgcaggct tacgctctta aacttcttga ttttcttagc gaggacgtca atcttttagc 1789981 gttagcttat accatgcagg caggacgggt tgaaatggag gagcgtgcgg ccttcattgt 1790041 aaaagacata aaagatttaa cggctaaact tcgggcgttt gccaatggcg aagaagagat 1790101 cgagggctgc tggaccggac gagccaagga gaatcaggag gcggctgggc tagcatcggt 1790161 aaatgcgctg aataacaatt tgataagaga cagtgaaatg atggaaatgg cgaaagcatg 1790221 ggttcaagga aagcgggtca cctgggacga cctatacggc gatcgcaagc cgcttaagat 1790281 cagtgttccg acctatccgt ttgcaaggga gcgctactgg atctcggttc ctgaaatgaa 1790341 aaccagcact gtgaatcata tcttacatcc gctggtgcac cgcaatacat cagactttac 1790401 tgagcagcgc tttagctctg tatttacagg cacggaattt ttcctgtcag atcatgttgt 1790461 acagggacag aaaattttgc cgggcgttgc ctatttagaa atggcaaggg aagcagcgga 1790521 aaaagctgca ggcgatctgg acggcgaaca aagagtggtg tcgcttaaag acattgtgtg 1790581 ggtgcgtcct atcacgatag aaagtgaacc aaaagaaata catattggcc tttttcctga 1790641 ggataacggg gacatttcct ttgatattta tagcagctct gaacataaag aagaagccct 1790701 gacgatacac tgccaaggtc gcgctgtcat ttcagatgaa gcggagactt ccattttaaa 1790761 cctttcatca atacagacag aatgcagcct ggacacagtg acgtcagaac aatgctatgc 1790821 agcgtttcga aagattgggc ttgactatgg cgagggctat caagggattg aaaaagtcta 1790881 tgtcggcaaa gatcaattgc ttgcaaaaat ctcgttaccc gcttttctaa aaaacgacaa 1790941 gcagcatttt gcgctccacc cgagtttgat ggattccgcg ttccatgcca cagtcggttt 1791001 tatcgttagc tcagtcaatg ccgctggaca agctcagacg ctgtctcttc catttgcgtt 1791061 acaggaggtt gatattttca gcccatgtcc agagaagata tggtcttata ttcgatacag 1791121 ttcagacagt aaagcggaga acaaagtcag aaagtatgac attgatttat gtgatgagaa 1791181 cggacgtgtt tgtgtgcgaa tgaagggtgc ctcgatgcgg gcacttgatg gagagcagca 1791241 ttcaaagccg caactattaa ctgattctca gctgaccggg catacggtga tgatccccgt 1791301 ctgggaacca gtctctctag aagcggagga taatgcttcg tttgctggta aaagagctgt 1791361 tttatgcgga gctgctgaag ctgatcggac tttcataaag catcattatc cgcaaatttc 1791421 ctttgtcgat atccgccctg cagatgacat tgaggcaata gcggacaaac tgcaagcgta 1791481 cggaagcatt gaccatgtat tgtggattgc cccgtcacac cggggaagta taggtagtga 1791541 tggacaagaa gaagctgttc ttcacttatt taagcttgtg aaagcatgcc tgcaattagg 1791601 ctatggcgag aaacaacttg aatggtctct tgtgaccgtc caagcgcagc cggttacgca 1791661 acatgaggca gtacaacccg ctcatgcaag cattcatggg cttgccggca caatggcaaa 1791721 ggaatatcca cactggaaaa tccgtcttct cgatcttgaa aaaggctgca catggccggt 1791781 aaatcacatg tttgcgctcc cagctgaccg ccttggccat gcttgggcct atcgtaatca 1791841 gcaatggcat cagcagcaat tgatcccata tcggtcctca ctgtcaggcg acacgctata 1791901 tcggaaaggc ggagtctatg tggtcatcgg aggagccggg tatatcggag aggcgtggag 1791961 tgagtacatg atccgccgct accaggcgca aatcgtttgg attgggcgaa gtcaacttaa 1792021 tgctgccatc cagtcaaaaa tagaccgact ttcggcgctt ggccctgagc ctttctacat 1792081 tgcagccgat gcagccgata agcattcact gcagcaggct tatgaacaag tgaaaaaacg 1792141 tcatcctcat attcacggga ttgttcactc tgcgatggtt ttatttgagc aaagcctgga 1792201 aaaaatgaag ccggaagaat tcaccgctgg actggcggcg aagatcgatg tcagtattcg 1792261 gatggcccaa gtgttccgcc aggagaatgt agattttgtt ttattcttct cttcgcttgt 1792321 agcccatatc aaaaatgtga agcaaagcca ttatgcctct ggctgtacat ttgcagatgc 1792381 ttttgctcac cagctttctc agagctgggc atgccctgta aaagtcatga actggggata 1792441 ttgggggaat agtgaagcgg ctgaggatga acattatgta cagctcatga atcaaatcgg 1792501 cttaggttta attgagcccg cggaggctat gaaggcgctg gaagcactgc tttctgggcc 1792561 agtcagccaa acagctttca ttcatacgac aaagcctgta gcagtcgaag gcgtgaatca 1792621 gaatgaattc atcactcttt atccagagca accttcagca gatgcagaga gcctgatgga 1792681 gcgtctgccg actacgggac gatttcaaag agtgacacat gaagagcttg atgatcttct 1792741 ttacaggctg ttgttaggac agctgcaaac agccgagctg tttgatggtt atacattatc 1792801 ggttgaacgt cttcaacaat ataagactcg tgaattttat ggaaaatgga ttcggcaaag 1792861 cagcgaattt ctcttgcagc atggctatct taagaaagtt ggagattcat tggtgaggaa 1792921 ggaccaagca gaggatatcg agctgctttg gctagaatgg aacgcgaaaa aagaaaagtg 1792981 gcttaaagac agcgagacaa aggcgatggt tgtattagca gaggccatgc tgcaagcatt 1793041 accggatatt ttgacaggga aagtccctgc aacagatatc atgttcccgc attcctcgat 1793101 ggaactggtg gaaggcattt ataagcataa ccaagtggca gactatttta ataaagtgct 1793161 tgccgataca ttattagctt atctggatga acgtctgaag cacgaccctg aggcatcgat 1793221 tcgcattatg gaaataggcg caggcacagg cggcacgagt gccggaatct ttgaaaaact 1793281 gaaaccatat caaaagcaca tcaatgaata ttgctataca gatctgtcta aagcattttt 1793341 gctgcatgca gaaaaggaat atggggcgga aaatccgtac ctgacatatc agctttttga 1793401 tgtggaaaaa ccgattgatc agcaggaatt tgaagcggga ggctatgatg tcgtcattgc 1793461 cgctaatgtc cttcacgcaa caaaaaatat ccgtcaaaca ctgcggcata caaaagcggt 1793521 aatgaaaaac aacggaatgc tgctgctgaa tgaaatggcg ggaaacagcc tgttccctca 1793581 catcaccttt ggtcttttgg aaggctggtg gctgtatgaa gatcctgcag tgcggattcc 1793641 cggctgtcca ggcttacatc ctgacagctg gaaagcggca cttgaaagcg aaggctttga 1793701 atctgtcttt ttcccggccg aggcggcaca tgatctgagt caccaaatcg tcgcagcctc 1793761 aagcaacggg ctggttcgac gtatgatgaa aaatgtgatc ttgccggaga aggttgtttc 1793821 acaagcgtct aatcaggagc cagcctacat tcataccata gattcagagg aagctggaca 1793881 atcgaaacat gctctcctaa gagaaaaaag cacagaatat atgaaaaaac taatcgggga 1793941 aacgttgaaa attcctgcag gaaagattga gtcatctgaa cctcttgaaa agtacggtat 1794001 tgattctatc gttgttgtcc agctgacgaa tacattgcgt aaagaatttg accatgtaag 1794061 cagcacttta tttttcgagt accagaccat tgacgcatta gtggagcatt tcatcaaaac 1794121 aaaaacagaa gctctgatga aattaacagg tcttgaccgt caagttcaac aacatacacc 1794181 ggccgaaagc agaacccaat cttcacagaa acctgatcag gccgctaaaa gaacacggcg 1794241 ctttcgcaag cttggcttca gcggggagaa agaaacaccg acaaacactc ttgcaagccg 1794301 tgacgttgcc gttatcggca tttctggacg ctatcctcag gcggaaacag cagaagactt 1794361 ttggaacaac ctaaaagaag gaagaaattg tattgaggaa attccgaaag atcgctggga 1794421 ttggaaagct tattacgata aagaaaaagg aaaagaagga tcaatttata cgaaatgggg 1794481 cggatttatc aaggatatgg acaagtttga cccattattc tttcagattt ctccgcttga 1794541 ggcagaaaga atggaccctc aggagcgatt atttctgcaa accgcttatg caagtattga 1794601 agacgcggga tacacgcctg actcgctctg ttcaagcaga aaaatcggcg tctttgccgg 1794661 agtcatgaac aaaaattatc cgactggcta cggctattgg tctatcgcca acagaatatc 1794721 ctatttactg aatttccaag gcccgagtct tgcagtcgat acagcctgct catcctccct 1794781 gacagcgatt catttagcgc tggaaagcat ctatagcgga tcgagtgatt gtgccattgc 1794841 cggcggtgtc aatttagttg tcgacccggt tcactatcag aatttatctg tcatgaatat 1794901 gctctctgct agtgatacat gtaaatcatt cggcgatgat gcagatggat ttgtcgacgg 1794961 tgaaggcgta ggcgccattg tgttaaagcc gctgcagcaa gcaatagcgg acggtgacca 1795021 tatttacggt gtgataaagg caagtgccat taatagcgga ggaaaaacaa atggatacac 1795081 ggttccaaat cctcatgcac aggcacaggt gattaaagaa gcaattgagc gcgccgacat 1795141 tcctgcccga accatcagtt atttagaggc gcatggaaca ggcactgcat taggagatcc 1795201 gattgagata gcggggttaa caaaagcatt cgagaaagat acgcaggaga aacagttttg 1795261 tgcgatcggc tccagcaaat caaatatcgg ccattgtgaa agtgcagccg gaattgcagg 1795321 gctgacaaaa atactttttc agtttaaata tggccaaatt gcgccatcat tgcatgctca 1795381 gcggttgaat ccgaacatcg agttcagcca tacgccattt gtcgttcagc agcaacttgg 1795441 tgaatggaaa cgcccggtga ttggcgggca agaggtgcct aggcgcgctg gcttgagcag 1795501 ttttggcgcc ggagggtcca atgcccatat catcctggaa gaatatattc caagaacggg 1795561 ggcgcaaacg ccgaaagacc atcctccagc gctgattgtg ctgtcggcca aaaacatgga 1795621 acgtttgcaa gaaaaagcgg aacagctgct tacagccatc aaacaaaaaa ggtactgcga 1795681 aacagacctg atcaggatcg cctatacctt gcaaacaggc cgtgaagcaa tggaggaacg 1795741 gctggccttt atagcggaat cactagagga tcttgagaga aagctgaacg attttatcga 1795801 aaacaaagca gacagcctgt atctggatcg catcgatgat aacaaaaaag cgttagcagt 1795861 cttatcagcg gatgaggata cggaaaaaat catagaagca tggatgagca aagggaaata 1795921 cacgaaactg ctggatcttt gggtgaaagg cttgtctttc gactggggca tgctgtacgg 1795981 cacccaaacg cctgtccgga tcagtcttcc ggcatatcca tttgcaaaag aacgttactg 1796041 ggcaccaggc gcggcaaagg ccccggtgtc tatagaacag gatcatgatc agcaaacaga 1796101 agaacctttc aaggttatga cgtttcaaga agtgtggaaa gaagagccgg cgactctcac 1796161 atcgaaacgt atcaaaacgc tcatctgttt tctgactgaa agagaaaagc aaaacgcatt 1796221 tgcttcagcc ctgaaaaacg ttgatcaaga caccaaggtc atttttatat cacagggcga 1796281 agtgtacagc aaacagtctg aatatagcta ccagattgtg cggcaagaac ccgttacttt 1796341 tgaaaaggcc ttccagagca ttaaagaaga acttggagag ccagatgcaa tcctctatat 1796401 gtggcctatg gaagacaagc gctgtataaa ggaccattcc tgtattgttt acctattaca 1796461 aggtatgtcc gcagcaaagc ttcatccttc acggctgctg ctggcaggat gttttgaaga 1796521 tagtcttgac cgaagttatc tggaatcatg gattggcttc gaacgttcac tcgggcttgt 1796581 ccttccgcac acaaaagtga ctggaatctt tcagcccgcg gaacaaggat cgatggatga 1796641 ttggacacgt aaagtctggg cagaattaca ggcttcaact gaacaaacgg ttttgtatca 1796701 gaatctgaaa cgatatgtaa atcacattga acagacaacg atacaaccgg acaacagcaa 1796761 attgaagtct ggcggtactt acctgattac aggcggtgta ggagggcttg gttatttatt 1796821 tgccaagcat ttggccaaaa actatgccgc aaacctgatt ttgacaggga ggtcgccttt 1796881 taatgatgag aagcaaaagc aaataaaaga attaaaggat ctaggcggcg aagcgatgta 1796941 tgcagaagca gatgtgtctg atcctatcgc aatgggagac tgcgtaaaaa gagggaaaga 1797001 ccgattcggt gccatcaacg gtgttattca tgcagccgga atcgagagcg actctgctat 1797061 ttttgacaaa aagatcgaaa gcttccagcg catcattgaa ccgaaaatca acggcacgat 1797121 agcgcttgat gaatggctta aaaatgaaga ccttgatttt atgtgttatt tttcttcttc 1797181 ttctgcggtt ttaggggatt ttggatgttg tgattatgcg attggcaata ggtttcagat 1797241 ggcttacgca caatacagaa atgagctgca taacggtaaa acgtttgtca tcaactggcc 1797301 tgtgtggaag gatggcggaa tgaagatcgg tgatgaggaa acaacggata tgtacctgaa 1797361 atcaagcggc caacgcttcc tagaagccga ggaaggtatc cgtatgtttg agcacatcct 1797421 agctcagcag gatgctcagc atctcgtgat agccggtcag cccagccgtg tcagcagatt 1797481 tttaggaatg actgaaccag ctattccaga accggccact caagcccctc tagcacaaga 1797541 aaacaaggat gaggtaaaaa cactaagcat tgaaaagcgt ttagaacacg acttgaaaga 1797601 gcatattcac acattgctta agatttcaaa ggacaagctg aatttgaaca aaaattgggc 1797661 cgacttcgga tttgattcga tctatttggc taaattctcg aacgtgttat caaagcattt 1797721 caacatcgaa gtgacaccgg ctttattttt cggctattca actttacaag aattgatcag 1797781 ctttttctta accgatcata aagagctgat tgaagcattt taccgggatg atgcatcaga 1797841 ggcgcaaaag ccccctgaag cttatgcagt aattcctgta gctttagaac cagaagccag 1797901 taaaaaaagc attcggcagg ttcacgatga gcctattgcc attatcggca tgagcggcag 1797961 gttccctcaa gctgattcgg tccatgagct gtgggataat ctgaaaaacg gtaaatcgtg 1798021 tatctctgac attccgggcg aacgccggga ctgggggaga gctaacagag atccagaaaa 1798081 agcagtgcca aggtggggtg catttttgaa ggacatagac cggtttgatc cgctgttttt 1798141 tcaaatatcg cctaaagaag ccgaaagcat ggacccgcgt cagcgcattt ttctagagga 1798201 agcatggcac acgtttgaag acgccggcta tatgggagat cggataaaag gaaaatcctg 1798261 cggtgtttat gtaggtgtgg aagaagggga atatgcgcat ctaaccggag atacggatta 1798321 cattaacgga acacaaaacg ccacattgtc tgcgagaatc gcatacgcat tggatttaaa 1798381 agggcctaat atggctttga cagcagcatg ttcatctgga ctggtggcga ttcaccaggc 1798441 atgttcagct ctgcgtcagg gggattgtga aatggcttta gcgggcggcg tcagcttgaa 1798501 tatttctcac atgtcttttg aggcgctgac aagggccgaa atgctgtctc cgaacggaca 1798561 atgcaaagtg tttgaccagg atgccaatgg tcttgtgcca ggtgaagcgg tggctgctgt 1798621 tctcttgaaa ccattatcaa aggcaattga agataaagat catatttatg gctgcatcaa 1798681 ggccagcggc gtgaattacg atggcaaaac caacggcatt actgcgccaa atccttttag 1798741 ccaggcagaa ttgatcgaaa acatttatga aaaaaatgaa atcaatccgc tcgatattca 1798801 atatgtgatg gcgcacagta ccggctcgaa tcttggtgat ccgcttgagg tccaagcgtt 1798861 aacgagcgtg ttcagcaaat atacgaagca gaagcaattc tgtatgatca gctcaattaa 1798921 acctttaatc ggacatacat ttgcagcgtc aggaacggtt gctttaatca gtatgctgat 1798981 ggctatgaaa aaccagatca ttccggccac tcatcactgt gaatcggaaa acccgtatat 1799041 tccgtttaaa gaaagcccat ttgtgctttg caaagaaaac cgttcgtgga tcaagaaaaa 1799101 tcagaagccg aggatgggaa cgatcagcac gactggaatc agcggcacca atgcacatgc 1799161 agtcattgaa gaatacattc cggatgatca gccgtccaca cagcggcatc aagggtcacc 1799221 gcagatcttt gtgatttcag cccaaaatga cgatcggctt caggatgctg cctgccgcat 1799281 gattgcgtat ctggagcaga atcataacct ttctttacct gatgtggcat atacgcttca 1799341 ggttgggaga aaagccatgg aagcaaggct cgcgatcgtt gcaaacaatc aggagcaatt 1799401 ggtgcgaaaa ttgaaggaat atgtggaagc aatgaagaat ggtggggtat caggccaaca 1799461 gagatccctt tatacaggat atacagaagg gattttagaa gaacaagatg aagcagttct 1799521 gcaagctctc gcaaaagaaa gaaatttgga aaacatcgcg gaatgctggg tgaaaggata 1799581 tcagattcct tgggaactcc ttcatgatgg cgatgacgtt cggatggttt ctttacctgg 1799641 ttatccattt gcaagggaac ggtattggat ttcgtcaggc actcagcaat cagaggccgt 1799701 taaacagcat tcacaagata tgaaaacaga gattgacgag ccgaatggca aaacccatat 1799761 tcaaaagatc attgttcaat ttttagcacg agaattgggc atatctgagg atcgaatcaa 1799821 tttcaaaaga aacttcctgg attatgggat ggattcaatt cttggccgaa aattgatgcg 1799881 gcatatcgaa aaaaccacgc agctgaagat ggccggccgg gaaatccttg aatgtcagac 1799941 agtccaagct ctatctgacc atttggcctt aaaagcggaa aaacaaaatc atagcgcagc 1800001 agcacatcac ataaagggca cgtatacaga cgagcaaatc attggattga tgcaagaggt 1800061 ggcgctaggg aaattggatt ttaagagtgt gcaaaacatc atagaaggga gtaaatcgta 1800121 tgaatcataa agaaattctc gatgccttca gatcaggaga attaaccatt tctgaggtgg 1800181 aagaacatct taaaggcatg aagcggcagt tgaaaagccc gctttcagaa gggcaaaaag 1800241 ggctgtggat gcttcaaaaa atgtctcctg ggatgagtgc atataacatt cctttatgct 1800301 ttcgcttcag caaaccaata catgcagaga cgttcaagaa agcccttctg tttgtacaga 1800361 gacaatatcc ggtcttagcc agtgtgattc aagaagaaaa tggcattcca tttcaatcgg 1800421 ttcagttatc aaaggatctt tattttgtgg aagaggatat atcagcaatg aaatcagcag 1800481 atattatgcc ttttctaaaa gaaaaagcaa aagaaccttt ccagttggaa gctggtccgt 1800541 tatggcgcac acaccttttt catcggttag aagaatgcat tgttcttata acaattcacc 1800601 atatcatatt tgatggtgtg tcgatgctga cattgatatc ggcgctattc gaagcgtatc 1800661 aacaattgct gaatgggatt gaacccttgc agcagccatc aacagctgat tattacgatt 1800721 ttgtcgattg ggaaaatcga atgctgactg gcagagaagg ggaagagcat ctcgcttact 1800781 ggaaagaaca gttgtctggg agtctgccag ttcttgattt gcctgctgac cgtccgcggt 1800841 cttcagcacg aaaatttaag gggcaagctt ataaaagctt gctccctcat cacctgagaa 1800901 atcaaattaa atcgtttgcc cgcaccaatc atgtgaatga atcggttgtg tttctctcca 1800961 tttacaaagt gctgctgcat cattatacaa aacaaaagga tatcattgtt ggcgttccga 1801021 caatgggtcg gcaagaagac agatttgaaa ccctaatcgg ttattttatc aatatgatgg 1801081 ctgttcggag caagaatatc ggatctcagc cattaacagc atttattcgg gaactgcagc 1801141 tgacagtggc tgtcggcctg gatcatgcgg cgtttccgtt ccctgcattg gtaagagagc 1801201 tgaatgtaga ccgctcggcc gcggattctc cggtttttca aacagctttt ctgtaccaaa 1801261 acttttttca ggcaacaggc ttgcaaaaag tgcttgaacc gtatcaaacg cttggcatcg 1801321 aatatattga agacattcgg caagagggtg aatttgagct ggcgctcgaa atatatgagc 1801381 aagaaaatga aacagtgctt catcttctgt acaaccctga tttgtacgaa ctgtcctcca 1801441 ttgaaagcat gatggagaac tatatgaagc tcgcgcagca catgatggag gacccgtctt 1801501 tgccgcttga agcctactct ttgcaattaa atcaagaaca aactagtttg ctggaacaat 1801561 ggaatgcgac agggacaaac atcgcaaatg acaagtgtat acatgaggtg tttgaggaaa 1801621 aagcgaaaca aacccccgat gcggttgctg tgatgtttga agacagatca cttacatata 1801681 aagaagtaga tgaaaaaagc acatctgtgg cagtctacct tcaacatcag ggtgttagac 1801741 ctgaacagcc cgttggcatt tgtgcagagc gttcgtttga tatgatcatc ggaattttag 1801801 gaatactgaa agctggcgga gcgtatgtgc cgttagatcc aagttttccg caagaacgat 1801861 taaagtacat gctcaaagac agtcaggcat ccattgtcct cacccaacct aacgttcatg 1801921 ataggatcag cggattaact ggcagccatg taaaagcgat caatatcgag ttagcttgcc 1801981 gaaacggtta tacagaccag caaagcagcg gtttaaagcg ggaagtaaaa ccggaacacc 1802041 tcgcttatat tatttataca tcgggaagca ccggagagcc taaaggggtt atggtagagc 1802101 atcggagcat tatgaatacc ctgaattttc ttgaatctca ctatcctgta acggctgagg 1802161 atgcatattt attgaagacg aactatgtgt ttgatgtatc gatctcagaa ttattcggat 1802221 ggtttattgg agatggccgt ctagtgattc ttccgcctaa tggggagaaa tcaccgcagc 1802281 tttgcatgga ttatattgaa acatataaag tgactcacat taattttgtg ccggccatgc 1802341 tgcatgtttt tttagaaatg gcgaaagaca acaagcgatt cacagaggac ggtccgctga 1802401 agtatatgat ggttgcaggt gaagccttcc ctaaagtatt agtgaaaaag gcggtatcgc 1802461 tctttacaaa ctgccgtgtt gaaaatatat acggaccgac ggaagcctcc atttacgctg 1802521 cgtatttcgg atgcggaaaa ggagatatcg caagtcacca tacaccgatt ggaaagcctg 1802581 tttccaacac gaaaatttat attgtggacc agcatttgaa gcctgtcccg atcggaaagc 1802641 caggtgagct ttgcatcgct ggagccggct tagcaagagg ctactttaaa aagccggggc 1802701 ttacggctga aaaatttatt gataatccct ttgaatcagg gacgaagcta tataaatcgg 1802761 gtgattcagc aaggtggctt cctgacggca acatagaata cttgggacgg attgacagcc 1802821 aagtcaaaat acgcggtttt cgcgtcgagc tgggcgcaat agaaacaaag ctgggtgaat 1802881 ttccgggcat tttagatcag gcggtagtgg tgaagcagct tgagggccat caacagctcg 1802941 ctgcttatta tacagaggaa agcggacatg cctctgccaa tccaaaagat ttgcgccttc 1803001 atctaaaatc gagtctgccc gaatatatga taccttcaca ctttatccgc ttagatgagc 1803061 ttccattatc gcccagcgga aaagtgaacc gtaaagaatt agaaaaacgc gagatcgtgt 1803121 tcaacagaag gaaaccaaat cacttgcaat taacggaaat agaggatcag gtgctgcgca 1803181 tttgggagga aacgctcaag gtcagcggat ttgggccgga agacggattt ttcgatgcgg 1803241 gcggcgattc gcttctggct gtagctgtgg ctgaacgaat caaaaaagaa ttcgattgtg 1803301 agtttcatgt tactgagctg tttgagtatt ccacgatccg tgcaatcagt gaatacattt 1803361 tggagatgaa aaactcagat ctagccggga cacaaaatga agatgatcat gatgacaaaa 1803421 aagatggaaa atacccgaaa cagaagattc ccccttattt tgacgacagt gttgcgattg 1803481 tggggatatc ttgccagttc ccgggtgcga aaaatcatca tgacttctgg aaccacatca 1803541 aagaaggcaa agaaagcata cgattctttt ctgaagaaga gcttcgcgca aatggagttc 1803601 ccgaagaatt gatacagcat cctgactatg tgcctgtgca atctgtgatc gaagggaaag 1803661 acttattcga tcccggtttc tttcaaatct cgccaaaaga tgctgagtat atggaccctc 1803721 agcttcgcct cttattgctg cactcctgga aagcgattga agatgcagga tatgtggcta 1803781 aggagattcc ggcaacaagt gtatatatgt ctgcaagcag caattcatat agaacgttat 1803841 tgccgaagga gacaacagaa ggacatgaat caccggatgg ctatgtctct tgggttttag 1803901 cccaaagcgg aaccattccc acaatgatct cacataagct cggattaaaa gggccaagct 1803961 attttgttca ttctaactgt tcttcatcac tagtcggttt atatcaagca tacaaaagcc 1804021 tgacatcggg cgaatcacaa tatgcgcttg tcggaggcgc aacattgcac gcacaatcag 1804081 cgatcggcta cgtgcaccaa aacgggttga atttttcaag cgacgggcat gtgaaggcgt 1804141 tcgatgcttc ggcggacgga atggccggag gtgaaggcgt agcagtcatc ctgctgaaaa 1804201 aagctgtgga tgccgtaaaa gacggagacc atatttatgc cattatgcgc ggaataggca 1804261 tcaataatga tggggcagag aaggcaggct tctatgcgcc aagtgtaaaa ggccaaacag 1804321 aagtgataca gcatgtattg gatacaacca agatccatcc tgaaacggtc agttatattg 1804381 aagcgcacgg gacgggaacg aaattaggcg atcctattga aatgtctgct ctaaataaag 1804441 tgtacaagca atacaccgac aaaacacaat tttgcggaat tggttcagtg aaaacgaata 1804501 tcggccattt ggatacagct gcggggttag ccggatgtat taaagttgcg atgagtttat 1804561 accataatga acttgcaccg accatcaact gtacggagcc gaatccggat ataaagtttg 1804621 aaagctctcc tttttatgtt gtccgtgaac gaaaatcgtt agagaaacac gcaggtgtcc 1804681 atcgggcggc tctgagctca ttcggccttg gcggaactaa cgcccatgca atatttgagc 1804741 aatatgaaaa catttctgat gcaggtgccg aaaacgaagg caatcagcct tacatcattc 1804801 ctatatcagc aaaaaatagt gaacggctcc aagtatacgc gaaggaaatg ctgtcctata 1804861 tcagtcaaga cgagcaaagg catttctctt taagagatat tgcatatacc ttccaagtcg 1804921 gccgtgaagc aatggataac aggatcgttt ttatagtgaa cgatctggaa gagtggaaac 1804981 atcagctgga agcttttgtg actggaaagc cgctcgcaga aggctgtatt caaggagaaa 1805041 aaacgagaat gacatccgct gaacagctgc ttggaaatgc tgaagcagat gatatggctt 1805101 catcgcggat atcaaaagaa gaattgagaa agcttgccga gatgtgggca aatggctttc 1805161 acgttgaatg gcgcaggctc tatccaaata taaagccacg ccgcatcagc ttgccgacat 1805221 acccttttgc cgaagaacga tactggcctg aaagcagcac cggcgctatc acaacaattg 1805281 aaccatctcg tttgcatcct ttggtgcacc ataatacatc ggttctgtca gagcagcgtt 1805341 tcagctccat tttcacagga caagagtatt ttattgccga gcatatcatt aaaggcatgg 1805401 cgattttgcc ggcggcggtc acgcttgaaa tggcaagagc cgctatagaa caaggaattg 1805461 gcggattgga ggatcatgaa actggaatca ggctgaaaaa tgtcgtgtgg gttcgcccgg 1805521 ttgtagcagg aagtgagccg gttcaggtaa atatcggact ttacgatgaa gatggcggac 1805581 atattgctta tcggatgtat ggtgatccgg aatccgctga tgcagaacca gttgtatata 1805641 accaaggtaa agcggaattg attcagttaa agcgagaaaa agcactggat ctttctaaga 1805701 tcaagaaaca atgtgatcaa agcaaaatgg atgctgcctc gttttatgaa gggatgatcg 1805761 gcgccgatta cggtccaggt tacaagagtg tagaggccgt atataaaggc gacggccagc 1805821 tgcttgccaa attatcactg ccagaatctg ttgcacatac gttgggcgat tatgttcttc 1805881 atccaagtgt aatggacggg gcgttacagg cggctgaata tttgcaaaat gtcgtcagag 1805941 cggaactttc agacactgaa gactttaagg cagcactgcc atttgcactg gaggaacttg 1806001 aggtttttcg tcagtgcgtt tctgacatgt gggtttatgt tcaattcaac tcgaaaaaca 1806061 aaccaggaga tttgatacag aaagtcgata ttcacctatg tgatgagcat ggcatgatct 1806121 gtgtgcggct gaaaggattt tcgacgagag tgatggaggc agatatacaa accgaaccat 1806181 caaaaatcaa cgctgaaact ttattgcttc agcccgtttg gcaagaacaa aaggctgcta 1806241 acagcttagc tgcaaaaaaa tatgcagagc atctcgtatt cctatgtgaa tatgatcatg 1806301 agacgagaaa acaaattgaa gcagccatcg aggatgtcca tgtatacagc ctggaagcaa 1806361 ggccttcttc agtagatggg cgtttccatt cttatacaga acaagtgttt aaaaaggtac 1806421 aagagatcat tcgtacgaaa ccgaaagacg gcattctcgt tcagatcgtg acctctgccg 1806481 agggagaaca gcaattgttt tcagggttga caggactgct gaaaacagct tgtcaggaaa 1806541 atgccaaact aaccggccaa atgattgaag tcagcagtga agaaagtgga gaaagcattg 1806601 ctggcaaact gttagaaaat caaatgagca gcgattcata tgtcaaatat caaaacggga 1806661 cacggtatat tgctgattgg cgtgaaatca aacaggcaaa aggagacggc agcaaaccgt 1806721 ggaaagacaa tggcgtttat ctcatttcag gaggtgccgg cggactaggt catatttttg 1806781 caaaggaaat tgcggaacaa acgaaaaatg cgacagtcat tctggcgggc cgctcacctc 1806841 ttagcgaaag caaaagcaaa aagctgaaag agcttcatag caagggggct gacatcacct 1806901 accggcaaac agatgttacc aataaaattg aagtctatca gctcattgac gacattcaaa 1806961 aaagatatgg ccgtctgaac ggtattcttc atagtgccgg aatcatcaag gacagctacc 1807021 tggttaataa acaggcaaaa gatctgcacg atgtactggc gcctaaagta aaagggcttg 1807081 tttatctaga cgaagcgagt aaggatttgc ctttagactt ctttattctc ttttcatctc 1807141 tttcaggaag tttagggagc attggtcagt ctgactatgc ggcagccaat gtatttatgg 1807201 atatgtatgc aggctatcga aataggcttg ccgacctcag ccagcggcat gggcagacgc 1807261 tttctgtaaa ctggccttta tggagagatg gaggcatgca ggtcgatcaa gaaactgaga 1807321 aaaggcttgt gcaacttgcc ggtattgttc ctatgagggc ggaaaaagga attcaggcat 1807381 tatatcaagc acttcattca gaggcaaacc aagtaatggt gatcgaaggc gatgtgcaga 1807441 aaataaaaca aaacatgctg gccaaaaacg cctcagcacc tatggaaaag aaggaagcag 1807501 aacacatgac tgaacaaata aatagcattg atgcagacag tttgctggat aaagtaaagg 1807561 cgatgttaaa gcgagagatc gccaagctgt taaaggtcaa gcttgaaacg attgacgatc 1807621 atgcagagat gacggtgtat ggttttgatt ctatctccat gactgaattc accaaccata 1807681 tcaatcgcgc ctatcagtta gagctgacgc caaccgtatt ttttgaccac ccgacgattc 1807741 atgcgtttgg caagcatttg tcagaagaat atcaatcggt atttgcgaag acatttgctg 1807801 tgcgcgctgt atcggctcag cttcagcctg ctgcgaaaca ggaacaagcc gtgcgtgcca 1807861 aagctaaaag acgcagaaag cagcaagtca tgctgccaaa cgccatacag agtgatgctg 1807921 ggcctgagcc aattgccatt gtgggcataa gcgggatttt ccctatggcg aaagacgttg 1807981 aggcgtactg gaacatctta aaagagggca aagactgcat gacggaaatc ccgaaagatc 1808041 gctgggattg gcgtgaatat gaaggtgatc cggcgaagga agtcaataaa acgaacgtga 1808101 aatggggcgg ttttattgac ggtattgcag attttgatcc attattcttt ggcatttccc 1808161 cgcgtgaagc tgaacaaatg gaacctcagc agcgcttact gctgacttac gcctggaaag 1808221 cgatcgaaga tgcaggatat tcggcgaaaa ggttgtcagg cacaaaaacc ggcgtcttca 1808281 tcggaacggg aaatacagga tacagctctc ttctatctaa agcgaactcg gcaatagaag 1808341 gatcagcggc agccaatacg agcccatcgg tcggtccgaa ccgggtcagt tatttcctta 1808401 atctgcatgg gccgagcgaa ccggttgata cagcgtgctc aagttcacta gtggcgatcc 1808461 accatgccat ctcttcaatt gaggaaggca cttgtgacat ggcattagcc ggcggtgtaa 1808521 atacgattat ccttcctgag gtgtatatca gctttgataa ggcgggagca ctgagcaaag 1808581 aaggaaaatg caagacgttt tcaaatcaag ccgatggttt tgcacatggg gaaggtgccg 1808641 gcatactgtt cctgaaaaaa ttaaaagcgg ctgaagaagc gggagaccat atttacggag 1808701 tcataaaagg cagtgcaatc aatcacggcg gccgtgcagc ctctttaacg actcccaatc 1808761 cgaaggcgca ggcagatgtt attcagtcgg catatcaaaa agcgggaatc gacccgaaaa 1808821 ccgtgaccta cattgaagcc cacggaaccg gaacggagct tggagacccg gttgaaatta 1808881 acggtttgaa atcagctttt aaagcattgg gtgtaaatga aggagacaca tcagccaatc 1808941 cttactgcgg attagggtct gtaaagacaa acatcggcca cttatcgctg gcagccggtg 1809001 cagcaggagt tattaaaata ttattgcagc ttaagcataa aaccttagtg aaaagtctgc 1809061 attgcgaaaa cgtgaatcca tacattcagc tgaaaaacag tccgttctat atcgtacggg 1809121 aaacggaaga atggaaagcg ctgaaaaatg aacagggaga agagcttcct cgacgggcag 1809181 gtgtcagttc atttggaatc ggcggagtaa acgcccacgt gattatcgag gaatatattc 1809241 cggaagcatc cgatgagaat ataccatcca tcgcgccgga acatccgggt atcttcgttt 1809301 tatcggctaa aaatgaagcg cggctaaaag aacatgcaca gcagctggca gatgcgcttg 1809361 ataagcaaac atatagtgac gtaaatctcg cccgaatcgc ttatacactg caagccggac 1809421 gggatgcgat ggaagaacgt ctcgggatta tttccggttc cattgaggat ttacagaaaa 1809481 agttaaaaga ctttgcagcg gagaaaagcg gtgtggagga tgtatttaaa ggcaggattg 1809541 ataaaggcac actccaaatg ctgacagagg acgaagagat tcaagaagcc gtcgagaaat 1809601 ggatggaacg gggaaagtat gcaaaattgc ttgaattatg ggtaaaaggg cttgatgtag 1809661 actggacgaa attgtatggc gagaatctgc caaagcgcat cagcttgccg acgtatcctt 1809721 tcgcaaaaga ccgttattgg atctctgatc atattgaaaa aagcggcagc attgatgcaa 1809781 atcaagcagc ctcccgcctt ggcggagccg tgctgcatcc attaatgcat caaaacacat 1809841 ccaatctctc ggaacaaagg tttagctcta tttatacggg agaagagttt ttccttgctg 1809901 atcatgttgt gaaaggccaa cggattttgc cgggagtggc tcatcttgaa ttggcgcggg 1809961 cagctgttga gcaggccgca gaggtacaag gtgtaccgcg catcatgaag ctaaagaatg 1810021 cggtgtgggt gcggcctatt gttgtagagg atcagccgca gcaagtacac attaggcttt 1810081 taccgggaga aaatggtgag atctcttatg aaatctatgg tcattcagac gttactggcg 1810141 aacagtcaat cgtctacagt caaggcagcg cggtattgaa tcctgctgaa aatttgccgg 1810201 cggttgattt gcaatctctg cgggagcagt gtcaggaaag tcatttcagc gtaaacgaag 1810261 tatacgacac ctatcgaatg attggatttg aatatggtcc tgcttatcgc ggagtgaaaa 1810321 aaatctatac agctgaacaa tttgttttgg caaaattgtc attgcatccg tcagctgcag 1810381 atacgctcag ccaatacaaa atgcaccctg ggctgatgga ttctgctttg caggcgtcaa 1810441 gcattttgac aggagccggg gataaccagc tgacactgcc ttttgcggtc caggagcttg 1810501 aagtcttcgg agcatgttcg tcagaaatgt gggtatacgc aagatacagc caaggcagca 1810561 aggcaactga taaggtgcaa aagcgcgata tggatatttt agatgagagc ggcaatgttt 1810621 gcgtacggat gaaaggatta tctttcagag cagcagaagg cggctctgga tcggcggaat 1810681 ctgatcaaac gctggcaacc ctgatgtttg aagaaaaatg ggtgcccaag gattttaaaa 1810741 aagaaagtcc tgagcctcat tacgaacggc acattgtcat gctttgcgac atgaatggcc 1810801 tctcaaaaga tcgcattgaa tcaagaatga caggagcgga atgcatcgtt ttggagtcat 1810861 tccgcgaagg acttgcagag aggttccaag attatgccga acaagcgctt gagacggtcc 1810921 agggtcttct caaaagcaga cctcagggca atgttctgat ccagctgctt acctctgcac 1810981 aaagaaagca gtactcattc tcagggctat cggcgctcct taaaaccgcc ggcctggaga 1811041 ataaaaaact aatcggccag acgattgaaa tcgattcaca tgaaaatgtt gaaagtgtaa 1811101 tagaaaaact gaaagagaat aaaaggcaca cagaagatca gcacatcaaa tatgaaaaag 1811161 gcaaacggta catcaatgat ctggatgaaa tgcaaataga tgatcgggaa ataagcatgc 1811221 cgtggagaga taaaggtgta tacctcatca cgggcggcgc aggaggactt gggtttattt 1811281 ttgcaaaaga gattgctcgc caagccgaac agcctgtgct cattctgaca ggcagatccg 1811341 cgttgaatgc ggatcagcag gcggagctta acgaacttca gcaattaggg gctcgcgcag 1811401 aatacaggca ggttgacgtg acacaaacgg aagcagcctc cgagcttatc acaagcatta 1811461 cgtctgatta cgaagacttg aatggtgtca ttcacagcgc tgggctgatt aaagataact 1811521 atcttatgag caaaaccaat gaagagctga cacaagttct cgctcctaag gtgaaagggc 1811581 ttgtgaatgt ggatgaggca accgagcatc ttgcgttaga tttctttatc ctcttttctt 1811641 caatatcaag tgttgccggc agcgcgggac aggccgatta tgcaatggct aatgcattta 1811701 tggacagtta tgctgcttat cggaatgcgc ttgtaaccgc catgtacagg cacggacaaa 1811761 cgttgtcaat caattggccg ctctggaaag aaggcggcat gcgcgcgaat aaagaaattg 1811821 aaaacatgac gttgaaaaac acaggtgtga ctccaatgcg gaccgagacc ggcattcaag 1811881 cgctgtataa aggtttggca tttggcaaag atcaagtcat cgtcatggaa ggattcaaag 1811941 acatgatgag ggaaaagctg actcaaaagc cgtcttctga tgatgtacca atgaaaacag 1812001 tgcaagtacg ggtgacatct gaagcaagaa tggatcaagg gaatatgttt gaccacattc 1812061 aagaagtttt aaagcaaaca atctctcaat tgctcaaaat caaacctgaa gagattgacc 1812121 cggacatgga gtttaatcaa tatggatttg attcgattac gttaactgaa ttcgcaaata 1812181 cactgaatga gaagtgcaag ctggatctta cgcctacggt cttctttgag cacgcaactg 1812241 tttatgcatt tgcagggtat ctgtcagaag aatatccaaa tgcttttaca gctcaaacgc 1812301 ctgccaaagc tgaggtgctg atgcagcctg tcgaacagaa tataaaaaat atgacgtttt 1812361 cgactgaaaa ccgctttgta aaaccttcgg taacaccaat gcaaaaggaa gctgatcaca 1812421 agcctgagcc tattgcgatt gtggggatga gcggcgtttt cccaaaggca aaagacgttg 1812481 aggaatattg gaagaacctg tcatcgggcg cagattgtat tacagaggtt ccaaaagacc 1812541 gctgggattg gcaggagtat tacggagacc ctctgaaaga agcgaataaa acaaacgtca 1812601 aatggggcgg ttttattgat gaagttgctg actttgatcc attgttcttc ggcatatctc 1812661 cgctggaggc tgagcagatg gagcctcagc agcgcctgtt aatgacctat gcgtggaagg 1812721 cggtagaaga agcgggacac tcagcgagaa gcctggcagg aaccaaaacg ggcatcttca 1812781 tcgggacagg aaacacaggg tacagttcac ttctgtcaaa tgtagacatc gaaggctcag 1812841 cggctgcgaa tatgagtcct tctgcaggac cgaatagagt cagttatttc ctgaacattc 1812901 atgggccgag tgaaccgatc gacactgcgt gctcaagctc tttggtcgcc attcatcatg 1812961 cggtttgcgc cattgaaaat ggaaactgtg aaatggcgat tgcgggaggg gtcaacacgg 1813021 tcgtaactcc gcaaggccat atcgcctatg ataaagccgg ggcgctgagc aaagaaggaa 1813081 gatgcaaaac attttctgac aaagccgatg gattcgcagt cagtgaaggt gccggcattc 1813141 tctttctgaa aaagctgaca gcggctgaac gagacggtga tcatatttac ggtgtcatta 1813201 aaggaagtgc ggtaaaccac ggtggccgcg caaattctct aacgactcct aatccgaaag 1813261 ctcaggcgga tgtcgtaaaa acagcatatg aaaaagcggg aattgatcca agaaccgtaa 1813321 cttatattga agcgcatggg actggaacag agctgggcga tccagtagaa atcaacggct 1813381 taaaagcggc atttaaagag ctgtatgaaa aaacggggga cccggctgtt catggcagcc 1813441 attgcggact tgggtcagcg aaaacaaaca tcggtcactt atcactggcg gccggtgtgg 1813501 ctggtgtcat taaagtgtta ttgcagctca agcataaaac gcttgtcaaa agtctgtaca 1813561 gtgaaactgt taatccgtat atcagactgg atgacagccc gttttatatt gtgcaggaat 1813621 cgagagagtg gcaggcgctt cgggatgaag ccggccgaga gctgccgcgc cgcgcaggta 1813681 tcagttcgtt cgggataggc ggcgtcaatg cccacgtggt cattgaggaa tatattccga 1813741 aagaaacaac ccatcctgca acagcaccag ccgtgacagc acagcacccg ggcatcttta 1813801 ttttgtcggc aaaggatgaa gatcgtctga aagaccaagc ccggcaatta gcagacttta 1813861 tcagcaagcg atctatcact gctcgtgacc tcactgatat tgcttataca ctccaagagg 1813921 ggcgtgatgc aatggaggag agattaggga tcatcgctgt ctcgactggg gacttgctgg 1813981 aaaaactgaa cctctttata gaagggggca ccaatgcgaa gtacatgtac agaggcagag 1814041 cagaaaaagg tatcgcacaa acattgagat cagatgacga agtacagaaa acgctcaaca 1814101 atagctggga gcctcacata tatgaaagac tgcttgattt atgggtaaaa ggcatggaaa 1814161 taggctggag taaactgtat gacggcaaac agccgaaacg catcagcctc cctacctatc 1814221 catttgcgaa agaacgctac tggataacgg atacgaaaga ggaggcagcc gcccatcaaa 1814281 cagctttaaa aacagtcgaa tcagcagctt tgcatccatt gatacatgtc aacacatctg 1814341 atttgtcaga gcagcgtttc agctcggcct ttacaggtgc tgagttcttt ttcgccgatc 1814401 ataaggtgaa gggaaaaccg gttatgccgg gcgtggcata tcttgagatg gttcatgctg 1814461 ccgttacaag agcagtgaga agaaccgaag atcaacaatc tgttattcac atcaaaaatg 1814521 ttgtgtgggt gcagccgatt gtggcggatg gccagcctgt tcaagtggat atcagtctaa 1814581 atccccagca ggacggcgag attgctttta acgtctatac agaggctgca cacaatgatc 1814641 gaaagataca ttgtcaaggc agtgcttcaa tccgtggggc aggagacatt ccagtccagg 1814701 atatcagcgc gcttcaagac caatgcagtt taagcacact ctcacacgac cagtgttatg 1814761 aattgtttaa ggcgatcggc attgactacg gacctggttt tcaagggata gatcggcttt 1814821 acatcggccg caatcaagcc ttggcagagc tttctctgcc tgctggtgta actcacacac 1814881 tgaatgaatt cgttcttcat ccaagtatgg ccgactctgc tttacaagcg tcgatcgggc 1814941 taaagctgaa ttccggtgac gagcagcttt ctctgccttt tgcgctgcaa gagctagaaa 1815001 tattcagccc gtgtacaaat aaaatgtggg tgtctgtgac atctcgtcct aatgaggaca 1815061 aaatacagag actggatatt gatttgtgtg atgaacaagg ccgagtgtgt gtaagaatca 1815121 aggggattac ctcaaggctg ctggaagaag gcatacaacc gccagacggg ccgacatcac 1815181 taggaaactc caaagcaact cttaacggag cgcttcttat ggcgccgata tgggatcgag 1815241 tgcagctgga gaagaggagc atttcgcctg ctgatgagcg tgttgtcatc ctcggagggg 1815301 atgacaacag cagaaaagct gttcaaaggg agtttccgtt tgccaaggag ctgtacattg 1815361 agccgaacgc atcaattcat agaattacag gccagcttga agcactcgga tcgtttgacc 1815421 acatcgtgtg gatgtctcct tctcgtgtga cagagtgcga agtcggcgat gaaatgattg 1815481 aagcccaaga tcaaggcgtc attcaaatgt ataggctcat taaggcaatg ctttctttag 1815541 gctatggaca gaaggagata agctggacga tcgtgacggt gaacacacaa tatgttgatc 1815601 agcatgatat tgtcgacccg gtcgatgccg gggtgcacgg cctgatcggt tcaatgtcaa 1815661 aagaatatcc aaattggcag acaaagctga tcgatgttaa aaaatacgaa gacctgccgt 1815721 tatctcaact cctttccttg cctgccgatc aagaagggaa tacgtgggcc tatcgaaaca 1815781 agatttggca taagcttcgt ctaattccag tacacaacaa tcaaccggtg cacacgaagt 1815841 ataagcacgg aggtgtttat gttgtcatag gcggagctgg cggtattggt gaggcgtgga 1815901 gtgaatatat gatcagaaca tatcaggcgc agatcgtttg gattggcaga aggaaaaagg 1815961 atgcagccat tcaaagcaag ctggacagat ttgcacgtct agggcgagcc ccgtattaca 1816021 ttcaagcaga tgcggctaac cgagaggaat tagaacgcgc gtatgaaaca atgaaacaaa 1816081 cacatcgtga aatcaacggc atcatccatt ctgcaattgt cttacaagac cgaagcctga 1816141 tgaatatgag tgaggaatgt ttcagaaacg ttcttgctgc aaaggttgat gtaagcgtgc 1816201 gaatggctca agttttccgg catgaaccac tggattttgt tttgtttttc tcttccgtac 1816261 aatcgtttgc aagagcttcc ggacaaagca attacgctgc gggttgcagt tttaaggatg 1816321 cttttgcaca gcggctttct caagtatggc cttgtacagt agccgtgatg aattggagtt 1816381 attggggaag cattggtgtt gtttcatcac cggattacca aaagagaatg gctcaggcag 1816441 gcataggctc aattgaagcc cctgaagcaa tggaagcttt ggaattgctg ctcgggggac 1816501 cgctgaagca gctagtaatg atgaaaatgg caaacgaaac gaatgatgaa gcggaacaga 1816561 cagaagaaac gattgaagtg tacccggaaa ctcacggctc cgccattcaa aagctgcgaa 1816621 gctatcaccc gggtgacaac acaaagattc aacaactgtt ataggagggg aaacgccaat 1816681 gctgaacaca gaagacattc tctgtaaaat gcttttcgca caattacagt ccatagggtt 1816741 tttcacagaa agtaaatccc agccggtatt ggagaatttc tatggcagat ggtttgaaga 1816801 aagccaatcg attttagaac ggcatcaatt tctcaagcga acggagaacg gacatgttcc 1816861 aacacgctca ataggcacca tgagcgagct gtggaaagaa tggaatgaac aaaaatttga 1816921 cctgcttcaa gacaataata tgaaagccat ggtgacattg gtggagacag cacttaaagc 1816981 cttgccggag attctgaccg gcaaggcgtc agccaccgat atcctgtttc cgaattcatc 1817041 tatggattta gtagaagggg tctataaaaa caatcaagtc gcagactatt ttaatgatgt 1817101 tcttgcagat acgttaacag cctatctgca agaacgtctg aagcaagagc ctgaggcgaa 1817161 gattcgaata ttagaaatcg gagccgggac cggcgggaca agcgcggctg tttttcaaaa 1817221 attgaaagca tggcagacac atataaaaga atattgttat acagatctgt ctaaagcttt 1817281 tttaatgcat gcagaaaata agtatggtcc tgacaatcca tatttgacat ataaacgatt 1817341 taatgtcgag gagccggcgt ctgaacagca tattgatgcg ggaggctacg acgcggtcat 1817401 cgcggcaaat gtgcttcatg ccacaaaaaa tatccggcag acattgcgaa atgcaaaagc 1817461 agttttgaaa aaaaacgggc tgctcctttt aaatgaaata agtaatcata atatatattc 1817521 gcatttgacg ttcggccttt tagagggctg gtggctgtat gaggatcctg atctccgcat 1817581 accgggctgc ccgggcctgt atccagacac ttggaaaatg gtgcttgaga gtgaaggatt 1817641 tcgctatgtt tcctttatgg ctgaacaatc gcatcaactc ggccagcaga tcattgccgc 1817701 tgaaagtaac ggagtcgtcc gtcaaaagaa gagaacggag gcagaagaag atccaagcca 1817761 tatacaaatg aatgctgaaa tcgatcattc acaggaaagc gattctctca tcgaacaaac 1817821 ggcacaattt gtgaagcata cgctggcaaa atcaatcaaa ctatcaccag aacgtattca 1817881 cgaagatacg acatttgaga agtatggaat tgattcgatt ttgcaggtga atttcattcg 1817941 tgaattagaa aaagtgacgg gagagcttcc aaaaaccatt ttatttgaac ataacaacac 1818001 aaaagaactc gtcgaatatt tagtaaaggg gcatgaaaat aagcttcgga cagcattgtt 1818061 aaaggaaaaa acgaagcctg caaaaaatga agctccactt caaacagagc gtacagatcc 1818121 taataagcca tttacttttc atacacgccg ctttgttaca gagcaggaag tcacggaaac 1818181 tcagctagca aataccgaac cactaaaaat agaaaagaca agtaatttgc aaggaacaca 1818241 ttttaatgat tctagtacag aagatatcgc aataatcggg gtaagcgggc gctatccgat 1818301 gtctaacagt ttagaagagc tttgggggca tttaatcgcc ggagacaatt gtattacaga 1818361 ggcaccggaa tccagatggc gcacatcttt attgaaaaca ttatcaaaag atccaaaaaa 1818421 gccggcaaat aagaaacgct atggcggatt tttacaagat atagaggcat ttgaccatca 1818481 gctttttgag gtggagcaaa accgggtgat ggaaatgaca ccggaactcc gtttatgttt 1818541 agaaaccgtc tgggaaacgt ttgaggacgg cggctatacg cgaacccggc tggataaatt 1818601 gcgggatgat gacggagtag gtgtttttat agggaatatg tataaccagt atttttggaa 1818661 tatcccatct ttagagcagg cagtcctcag ctcaaatggg ggagactggc acattgcaaa 1818721 tcgcgtttcc cactttttta acctgaccgg accgagtatc gctgtcagct cagcatgctc 1818781 tagttcatta aacgccatac atcttgcgtg tgaaagcctg aaattgaaaa actgctcaat 1818841 ggcgattgct ggaggtgtca atttaacact cgatctctct aaatatgatt ctttggagcg 1818901 tgccaatctg ctgggaagcg gcaatcaaag caaaagtttt ggcaccggaa acgggcttat 1818961 tcccggggaa ggcgtcggag ctgtcctgtt aaaaccactt tcgaaggcga tggaagatca 1819021 ggatcatatt tacgctgtga tcaaaagcag ttttgctaac catagcggcg gaagacagat 1819081 gtatacagct ccggacccga agcagcaagc aaagttaatt gtcaagtcga ttcagcagtc 1819141 gggcattgat ccagagacta tcggctatat tgaatcggcg gcaaatggtt cggcgctggg 1819201 cgatcctatt gaagtaattg ccttaacaaa cgcgtttcaa caatatacaa acaagaaaca 1819261 gttttgtgcg ataggctctg tcaaatccaa tctggggcat ttagaggcgg cttccggtat 1819321 ttctcagctg acaaaagtgc tgctgcagat gaagaaaggg acgctggtgc cgacaattaa 1819381 cgcgatgcct gtcaatccaa atattaagct ggaacacacg gctttctatc ttcaggaaca 1819441 aacagagcca tggcatcgct tgaatgatcc tgaaactgga aaacaattgc cgcgcagaag 1819501 catgatcaat tccttcggag cggggggagc ctatgccaat cttattatag aagaatatat 1819561 ggagacggcc cctgagaaag aacatatcgc tccccgccag caggaattca ctgccgtttt 1819621 ttcagccaaa acaaaatgga gcctgcttag ctatctagaa aatatgcaat tgtttttaga 1819681 gaaggaagct tctctggata ttgaacccgt tgtacaggct ttacacagga gaaaccataa 1819741 tttagagcat aggactgcat ttacagtggc atcgactcaa gagctgatcg aaaaactaaa 1819801 ggtgttccga acatcaagag aaagctcact ccagcaaggc atctatacat cattcgattt 1819861 acagccatgt gcggaatcag catctaggga tagagaaata aacgcagcag agcaatgggc 1819921 acaaggggca ttgattgctt ttaaagaagc tgatataggg aaccgaacag gctgggttca 1819981 tctgcctcac tatgcatttg accataatac atcatttcat ttcgatgtat cgtctatcaa 1820041 tgagaaatcg tcagatgttg aagacaatat caatcagccg gtcattcaag atcaattcac 1820101 ttatgatgag ccttacgttc aaggacacgt cttcaacaat gaacgggtgc ttgtcggtgc 1820161 cacatatggc agtctggcca ttgaagcatt ttttaacctg ttccctgagg aaaacagcgg 1820221 ccgtatcagc aaattaagtt atatcagtcc aattgtcatc aaacaaggcg agaccattga 1820281 acttcaggca aagccgctgc aaaaagatca agtcatagaa ctgcaaatca tgtatcgcga 1820341 gccgtcctct ggtttgtgga agcctgccgc aatcggacaa tgcggaatcg gttcttttga 1820401 gcccaaaaaa gtcaatatcg agaacgttaa gcattcatta actaagcttc atcacatcga 1820461 tcagatgtat aaaaccggaa acggtcctga atggggagag ttatttaaga caattactca 1820521 tctctacaga gatcacaagt ctatactggc aaaaattcgc ctgccccaaa gcgggctggc 1820581 aaacgggcac cattacactg taagcccatt gatgacaaac agcgcgtact tggctatcct 1820641 cagtttctta gagcagtttg acatgacagg cggcttcctg ccgtttggaa tcaatgatat 1820701 ccagtttaca aagcaaacga taaaagggga ttgctggctt ttgattacat tggttaagaa 1820761 tacaggtgac atgttgctgt ttgatgtaga tgtgatcaat gagtcgtcag aaacagtgct 1820821 gcactactcg ggctactcgc ttaaacagct tcgtatttcg aatcaaagag gaaatcaaaa 1820881 taaggccatc aaagccagca atctgaaagc tcgtatcaga agctatgtaa cagataaact 1820941 ggcagtaaac atggccgatc cgtcaaaatt gtcaattgca aaagcgcata tcatggattt 1821001 tggaattgat tcttctcaat tggttgcact gacaagggag atggaagcag agacaaagat 1821061 cgaattaaat ccgactctgt tttttgaata tccgactatt caagagttaa tcgacttttt 1821121 tgcggacaaa catgaagcat cttttgctca gctgtttggt gaagctcatc agcaggaaga 1821181 acgcccagct caaatcgaaa accaaatgaa acagattccg gcatacgaga cgaacacgga 1821241 taaaacaatc gaacacgcgg cagacggcat agccattatc ggcatgtcgg gacagtttcc 1821301 gaaagcaaac agcgtaacgg aattttggga taaccttgtc caaggaaaga actgtgtctc 1821361 tgaagtgccg aaagaacgct gggactggcg caaatatgcc gcagccgata aggaagggca 1821421 atcaagcctt caatggggcg gttttataga aggaataggt gagtttgatc ccctgttttt 1821481 tggcatatcg cctaaagaag cggcgaatat ggacccacag gagtttctgc tcttgataca 1821541 tgcatggaag gcgatggaag atgcaggctt aacagggcag gttttatcca gccgcccgac 1821601 aggagtattt gtcgcagccg gcaatacgga tacagctgtg gttccttccc taattccaaa 1821661 ccgtatatcc tatgcacttg atgtaaaagg gccaagtgaa tattatgaag ctgcctgttc 1821721 ctcagctcta gtggctttgc acagagctat acaatccatt cgaaacggcg aatgtgagca 1821781 agccattgtc ggggctgtga atttgctgct ttcaccaaaa ggctttattg gcttcgactc 1821841 aatgggctat ttgagtgaga aagggcaggc caaatccttt caagcagatg caaatggctt 1821901 tgtcagaagt gaaggagcag gagttctcat cattaaacca ttgcaaaaag ccattgaaga 1821961 ttctgatcat atttattcgg ttattaaagg ttcaggtgta tcgcatggcg gcaggggaat 1822021 gtcacttcac gcgccaaatc cggccggcat gaaggatgca atgctgaagg cttatcaagg 1822081 agcgcaaatt gatcccaaaa cggtgaccta tatagaagcg catgggatcg cctctccatt 1822141 ggcagacgcg atagaaatag aggcgttaaa gtcaggctgc agtcagctcg aattggaact 1822201 tccacaggaa gtacgggagg aagcgccatg ttatatcagc agcttaaagc cgagcatcgg 1822261 acacggtgaa ctcgtctcag gcatggctgc tcttatgaag gtcagcatgg cgatgaagca 1822321 tcaaacaata ccaggcatat ccggattttc gtctttgaat gaccaggtgt cattaaaggg 1822381 cacccgtttc cgagtgactg ccgagaatca gcaatggagg gatttaagtg acgatgcagg 1822441 caaaaaaatt ccgcgcagag cgagtatcaa cagctatagc tttggaggcg taaatgcgca 1822501 cgtcatttta gaagaatata ttcctttacc aaaaccaccg gttagtatga gtgagaatgg 1822561 tgcccacatt gtagttcttt ctgcaaagaa tcaagacagg ctaaaagcaa ttgctcaaca 1822621 gcagcttgac tatgtgaata aacaacaaga actgtcatta caagattatg cttatacact 1822681 tcaaaccggc cgagaggaaa tggaagaccg cctggcgctc gtcgtccgca gtaaagaaga 1822741 actggtaatc ggcttgcaag cctgcttagc agaaaaaggc gataagctga agagttctgt 1822801 acctgtcttt agcggaaatg cagaaaatgg ctcgtcagat ctcgaagcct tgctggatgg 1822861 tccattaaga gaaatggtga tcgagacttt gttgtctgaa aacaaccttg aaaagatcgc 1822921 gttttgctgg acaaaagggg tgcaaatccc atgggaaaag ctttatcaag gaaaaggtgc 1822981 ccgcagaata ccgttgccaa cctatccatt tgaaaagaga agctgctgga acggctttca 1823041 agcagtagag aatacgcctt ctgtttcaca ggatgagcgt atcaacaaca gcagcgatca 1823101 tcacatatta gcaaatgtac tagggatggc tccggatgaa ctgcagtttc ataagccatt 1823161 gcagcagtat ggatttgatt caatttcttg catacagtta ttacagcaat tgcaatcaaa 1823221 ggtggaccct ctcattgtct tgacggagct tcaagcatgc catactgttc aggacatgat 1823281 ggacttgatc gcaaagaaac aggaggatac atccttacaa aatgatcaag ctcgcacgtt 1823341 tccggaatta ataccgttaa atgacggcaa gcgggggcgc cctgtctttt ggttccatgg 1823401 cggagtagga ggagttgaaa tctatcagca atttgcacaa aagagccagc gcccttttta 1823461 cggcattcaa gccagaggat tcatgactga ttctgctcct ttgcacggaa ttgaacaaat 1823521 ggcttcctat tatatagaga tcattcgatc catacagcct gaaggtcctt atgatgtagg 1823581 cggatattcc ttaggcggga tgattgcata tgaagtcact cgccagctgc aaagccaagg 1823641 ccttgctgtc aaaagcatgg tgatgattga ctccccatat cgttctgaga caaaagagaa 1823701 tgaggcatct atgaaaacgt caatgctgca aacaattaat acgatgctgg catcgattgc 1823761 gaaacgggaa aagtttacgg atgttctcat cagccgtgaa gaggtggaca taagcttaga 1823821 ggatgaagaa ttcctgtctg agttgattga cttggcaaaa gaacgagggc taaacaaacc 1823881 agataaacaa atacgtgcgc aggctcagca aatgatgaaa acacagcgcg cctatgattt 1823941 ggagtcgtac actgttaagc ctctccctga tcctgagacg gtaaaatgtt attatttccg 1824001 caacaaaagc aggtctttct ttggtgattt agacacttat ttcactttat caaatgaaaa 1824061 agaaccgttt gatcaagctg cctattggga ggaatgggag cggcaaattc ctcatttcca 1824121 cctggtggat gtcgattcaa gcaaccactt catgatatta accgaaccga aagcgtcaac 1824181 agccctgtta gaattttgcg aaaagctcta ttcaaacagg ggagtagtga atgcgaattt 1824241 ccttaaggct ttccggaaga aacatgaagc gagggaagaa aaagaaacag atgaattggt 1824301 gaagcgctga gaaaacacaa acgccccctc ttttaaaagg gggcgttttg aatgttattt 1824361 tgaaagtgaa acagggagac tttctaatcc tcttaaaaag acattttttc tccattgaat 1824421 gtcatcaggt gcaaccgcaa gttcaatatc aggaaatctc ttcaaaagtg ctttaaatgc 1824481 aatgtggcct tccagcctgg caagaggcgc tcctaagcag aaatgaatgc caaaaccaaa 1824541 agaaatatgt ctattaggcg accgatttat atttaatatt tcggggttct caaaaaaatt 1824601 cgggtcgcga ttggcagatc cgatgcctat aaaaatcatg tctcctcttt tgatcgaatg 1824661 ccccttatat gtaaagtctt cgatggccca ccgatttgcc atcataacga caggtgaggt 1824721 gtatcgcagc aattcttcaa ccgctgtagc gatcatttca ggctgctgct tgagcttctc 1824781 acattccttc ttgtgctgca gcaatgcgag ggtgcctgag ccgagtaagt taacagttgt 1824841 ttcaaggccg gctacaacga gcaagaacag catcgaatag agctcttttt cgcttaactt 1824901 gctgccgttt tcctcagcat gcacaagttt gctgattaaa tcgtcttttg gctttattct 1824961 tctgtcatgg atcagcttag cgatataatc tttaaattca cgaagggcct gatttgtcag 1825021 ctctctatta ccttcagagg tatcaaccat cgcattggtc cagatttgaa actgtgaccg 1825081 atcttctttt gggattccca tcaattcaga tataacaata aaaggcaaag gggaagcgaa 1825141 ggatttcatg atatccgctt tattttcttt ttccatttca tctaaaagct gttcagcaat 1825201 ttgttcaatg ctgccgcgca gattttcaat ggttcgggga gtaaatgctt gatgaacaag 1825261 tgatctcagg cgggtatggt caggtgtgtc ttttgccagc atatgatcgg atacaaaatc 1825321 gatatcttca ctaacgttga gcattttgat ttgttcttgg ttcatcacat tttttacgtc 1825381 tcttgtaatt cgattgtctt ttaaaaaggc catacaatca tcgtatcggg taattaacca 1825441 ggccggatat gtggctccga accgttttaa ttcaaatcgg tgaatgggct cttcctctct 1825501 aaatcgtcct aaaactgaaa aaggattgtg atgaaactct ttaccatgcg gatgaaacat 1825561 caatttttcc atttgcattc tcctcgccta atagggtaaa tagatgaatc aaattgctga 1825621 attagtttac aaaaaacaga atgatttgaa atgtaatcct gtctctaaaa ctatatatct 1825681 atcttaggcg tcattcaata gggagaagaa cgaaaaaagt gaaaaaacgg ctcgatataa 1825741 agcagcgcct ttgaacgaaa gctcaaaggc gctacgctgt attattttga tgaaagtggc 1825801 tgtcagctgt gctggatatc aattgtatat actgcacgat ctgttacgac cttcaatcct 1825861 tcgttttctt ggtgaatatg aagctcacct aataaaggaa tctcataggc attttgcgga 1825921 agcggtacgt ttccgtcctc agtgaatgtt gttccttcgc cttctaaaac aagctcttct 1825981 ttcgcaacat aatcatcagg atgattcgta ctgcgtatag ccactttttg aaggtggaga 1826041 acaatctgat ccaagtctga tatctcttca tcatgggtca attcaccttt tctaatatca 1826101 agcgtctggc cgacttttga ttccagccat tgagaaagct gtgtattcgt gtgtgccatc 1826161 aatattcctc cttttgatct acacgatact attcccaatt gctgcatctt ttacacggga 1826221 aagagccgcc ccactcttta tgtatgaaac agttcgctgt tgagtgcctt gatatagcgt 1826281 acggcagaac gctggaccga ttcgtcggca ttttctttga caactttaga gaaagcattg 1826341 taaagccggt tgaattgaag cggttttact ttggctgcta tttcttcaac tttggaggcg 1826401 ggaaggggaa tgagatttgg gtagctgtac ataaagctga cccagtttcg atccgccgca 1826461 accgtaatga tatctccggt caatagacag cctttccctt cattgccctt gctccaatgc 1826521 aaaacagcac cgcctttaaa atgtccgccc agtcggtaaa ggtccagtcc cggcttcata 1826581 ttgagcgttt cccctgacca gaagtgaatg tgattgcttg gccttgtcac ccattcttta 1826641 tcatcctcat ggatatagat cggcgcctga aacgcttcag cccactcaac ctgagtagag 1826701 taataatgtg gatgagacaa ggcgatggct tgaataccgc ctaattcgtt gatttggtca 1826761 attgtctttt ggtcaagata tgtcatgcaa tcccacagca cattgaagcc cttatgctga 1826821 ataagatggg ctgtttgtcc aatcgcaaac tctggttcag ttttgatgct gtaaagatgc 1826881 tcttcttcct ttttaaggat gttttgaagg tttcctttct cacgcatgtc ttcaagggtt 1826941 gtccaagttt gtccatcggg atgaatatac tgtctttcat cctcgcaaat cagacacgag 1827001 ttgggcggat ctacagtctg tgcatgttgc acaccgcatg tattgcagat ataatatggc 1827061 actttcttca cttccttcat ctattttcca ttattttacc ttatgattat gaatattcaa 1827121 acgaaaaaac cggcagttct gctgagagag aattgccggc ttttgatgat gtttattggc 1827181 cgggaacgga attttctgcg ttgacagcgc ccgctccgta gatattcgga tcttcatctt 1827241 tccatttgtc cgtgccgttt ttcaaaagct cttttacttc atcaggggta agatccgggt 1827301 tttgctgaag aattaaagct gcgattcctg cgcaaatcgg tgttgccatc gaggttcctg 1827361 acattgtaaa gtactgagac cctacacggc ttgacttttg gagcttatca atataagaat 1827421 tcggagagcg aagggaaata atattaacac ccggcgctaa aatatcgggc ttttctttcc 1827481 cgtatactgt cgggccgcgg cttgagaagg aagcgacagt atcatcatcg ctgcttgcag 1827541 tattgttatc gtcaagcgca cctactgtaa tcaccttttc gctcacgccc gggcttgcaa 1827601 tggtctgcga atcagggcct gagtttccgg cagcgacaca gacgacaatc cctgcgctcc 1827661 acgcttcctc aaccgctctg actaacggat cttcctgttc atgatcatat ctaagggcat 1827721 cgcccccgag cgacatgctc ataatatcaa tcggttcatc ggggttgtcc tcattgtatt 1827781 gaatacacca ctcaacaccc tctataatat ctgctaacgt tcctgaaccc tgcttgttta 1827841 atacctttac gccgatgaga ttggcttccg gtgcaggtcc gcggtattga ccggaagagg 1827901 atgcaccgct gcttgcgaca tcacctgcac agtgtgtgcc atgaccatta tcatcgtacg 1827961 gctctgtttt ttgattgacc atgtccgcga atccgataat tcttccttct agatcaggat 1828021 gcgggtagat tcctgtatcg acaacagcga cagtaacacc ttttcctgtc agggtttgcc 1828081 cgtttctgac gacttccttc gcatggcttg cttcggttgc cgtgtctaaa agcgctttga 1828141 cttcgcggtt taaatacact ttacggatat tgctgcattc agagagaagg gaatgtaatg 1828201 ctgaaggagt aacctcggcg ctgcagcagt tgattttgtt gaagcggctt tttagcttgc 1828261 tgcgtttttc tttttgcagc acctctccag ccatttgaaa gccggtctcg tgacagcctt 1828321 cctcaaattc gataatgact gacatttttt ttctgttttg caatttggtt tcgaaaaatt 1828381 tatgcaagaa gcaaggagtc catttgaagg gcttgtaaag ttgcaatacg gtttcccgta 1828441 acggccaatc tagcttgtga gcatttgctc tcaccatttg taccatagag tacccaaaca 1828501 tgtattttcc tcctattata aggttctctg tatactctat gaacagatga taggtttggt 1828561 aagtttgttt gtcctctgta agagacagac aagagtttgt ttttctgaat ctttcgcatt 1828621 agatacgata gattcagaag ctgaggaaat cattggggat tgaaaaagaa cgtttgttcg 1828681 tattataatg tgatcatatc aaactgggaa ggggagagca accgtatgaa tttctacttg 1828741 caccgatctt tggaaagcca aatgccaatc agcattatat atgaagaaag acggaacgat 1828801 tagtaaaaga acgattattg tgagacagaa aagcaaaacg aaaatcaaag cattttgttt 1828861 ttcgaaacaa cagatcagaa catttttatt ggactctatc ctctcctgtg attttgtgag 1828921 aacaaataag caaaatctct attctgcagg ccggtaacag ctgtccgtct cagcaaccgg 1828981 gcagcctgtt actaaaaccc tccttaaacc tatatacatt tatttgccaa gtgaggttgt 1829041 tcctaccttt tttgtctttc ctctcaacct tttttcactc ttatttgaaa tgaaccgcta 1829101 ataaccgtga caatcaattg attttttgaa accgggaact ttttcactga tgatattgtg 1829161 tatacaatgg taagataaaa cctattggct aaacctcata taatgaaccg cgccattctt 1829221 atgaaaggag ttaaacatga gaagattttt actaaatgtc atattagtct tagccattgt 1829281 cttgttcttg agatatgttc attactcatt ggaaccagaa ccatcaaatc agccagatac 1829341 atattcaaat ttcagcagct tggcagagaa tgagagccca gccgattacg atatttcata 1829401 taatgagaaa aaaggaagca aagtcttaat tatgtctccg catggcggaa gaattgaagg 1829461 cggagtaagt gagcttgtgc gttatttcaa taatgaatac tctacatacc tatttgaagg 1829521 gttgaagtcc catgataacc aaacactgca cattacaagc accaactttg atgagccatt 1829581 ggcaaaaaag aaaatcaagg agcatcaata tgtggtggct tttcacggat ataaaggaga 1829641 gaacaagaat acccttgtag ggggaacaga ccgaaagcgg gcgaaaatga ttgtgagagc 1829701 ccttgagcgg agagggtttt ccgctgagtt agcgtcgtct aaaagcggtc ttgctggatt 1829761 gaatgccgaa aacattaata accaagggga aacggggcta agtatccagc tggaaatcag 1829821 ccgtgagcag agagaagcat tttttgatga tttttattat aaaaatagaa aatacacaaa 1829881 gaacagtgaa ttttatgctt atgtcagtgc gatcaaaggt gtcctggaaa aagagtattc 1829941 gtaacaagca gatcagaaga caaaataaga gaagatcagt agactgaaat aggataaaaa 1830001 aggaggcaaa acaatggcag atcatcattt ttatttaaaa gcgaactggc cgggtaaccg 1830061 taatgatgtc ggtacgatcg aaagcggaaa cctgatcaca tcgatttcca ttcctaaaga 1830121 aatggatggc ccgggagaag ggaccaaccc agatgaaatg cttctcgggg cggcagcgac 1830181 ctgttacatt attacacttg cagcgatgat ggagagaagc gggctggaaa aagaagactt 1830241 acagatggag tcagaaggca ttgtcaacgt tacaaaagga gtctttacat acaaaaagat 1830301 cattcaccgt ccctctgtcg tgcttaaaca tgatgcttca caagacgacg tcgcattggc 1830361 gcacaaactt tgtaaaaaag cggagtcgtc atgcatgatt tcgcgtgcaa ttcaaggaaa 1830421 tgtcgagctg cagcttgaag cctctgtgaa actgggtgga gaataaagaa aacagacggt 1830481 cactcacagg ccgtctgttt tttatcttca gcgtgggctt tcgattgatt tagcacgacc 1830541 acgcctgcaa tgacaagcgt gagaccgaat acacctttta aactgatggt ttcgccaaaa 1830601 agcaaaaacc cgacaattgc tgtaagcgcg gtaccaacgc ccgaccatgt tgcatacgcg 1830661 cttgataagt caattgtttt taaagaaaag cttagaaacg taaaagcaga aagaaatccg 1830721 actatgactc cggcaatggg ccaggcttgt gtaaatcctt ctgaaagctt caacatcgtg 1830781 ctcccaaaca cttcagatac aatggcgaga gccaaataaa gcaatcctct catcttcatc 1830841 actcctttac ggccaattaa gtaacacgac ccctgatagt aataaaagaa tcccgataag 1830901 ccctttggca ttcagatctt ccttgaacca ttttactccg atcactgtcg tcagcaccgt 1830961 gcctgccccg ctccaagtcg cataggagag gctcagggga atatggttta aagtcaggga 1831021 cagcatataa aaggcgaggg aatagccaat aacgaccaaa gcacttggct tccacttttt 1831081 gaagccatca gatactttca gcatggctgc tcctatcgat tccgaacata tggcaatcgt 1831141 gaggaatata tatcctatca acatcatgaa ttctcctcac tatattttta gattagaaaa 1831201 aaaacttcag ctagaaaaat attagtgtat gcctatgtat gagtcaagag attcattttc 1831261 acacacttaa aaagacccct ttttaagggg tcttttgcgt ttaataataa aaagggaacg 1831321 gggcatacgg ataatagggg tatccgccat acaaataagg attaaataaa gcgcttccta 1831381 taagcccgcc tgcaaggccg ccgataaacg gtcctccaaa aaatccgaat ggccggccaa 1831441 acccataacc aaatccgggt cttccaaacc cgtaaccgaa cccgaacggt cttccaaacc 1831501 caaatggtct cccgaatccg aacggccttc caaatattct tgtatcttca gggctgaaat 1831561 gctctaactc gttcatgttt tctttcctcc tgtaataaag tgtagatgat gcagtgtatt 1831621 caccctgccc ggatttgatt gggcgaatcg aggaaaagga ggatgtgaac acattgggcc 1831681 tgtatcagtc tgactggtca aaagcaccgc cccacgcaca tgcttatcat gtcaaaacaa 1831741 cgagagaaca gggccattat catctcatcg aagggtttac tcagccggca aacggatcaa 1831801 ataccgatca gcatacacat tactatacag ggatcacttc atttgaaaac ggccattttc 1831861 atcggtatta cggaatctca ggaccggcga ttcccttagc agatggcaca cattatcatg 1831921 aaatcgaaga aacgacgtat ctggcctata acgagccgat tgagatccag tacggagggg 1831981 ttgtgtacga tcccggagat gacagaagaa aaacgcatcg tcataccctg aaaggaaaga 1832041 caagggaaat tgtcggcaat gagccgctcg gctggtagaa ggatgtttac cgatgcaaaa 1832101 aaagggcaaa atggataggt ggttgtccat gttgaatgct ataatggggg gagatttata 1832161 aaagagagtg atacatattg aataatacga agcagcccgt tgtcatttta gtcggaccga 1832221 cggcagtggg gaaaaccaat ttaagtattc agctagccaa atccttaaac gcggaaatta 1832281 tcagcggaga ttcgatgcag atttataaag ggatggatat tggaacagct aaaattaccg 1832341 aacaggagat ggagggagtg ccccatcatc tgattgacat tttagatccc caagactctt 1832401 tctctactgc cgattatcaa agcttagtaa gaaataaaat cagcgagatt gcaaatagag 1832461 gaaagcttcc gatgattgtc ggcggtacag ggctttatat acaatctgtg ctttacgatt 1832521 atacatttac ggaagaggca aatgatcccg tgtttcgaga gagcatgcaa atggctgctg 1832581 agcgggaagg cgctgacttt cttcatgcca aacttgctgc agcagatccc gaggcagcag 1832641 ctgcgattca tccgaataat acaagaagag tcattcgcgc actggaaatt ttacatacgt 1832701 ccggaaaaac gatgtcccag catttgaagg aacaaaaacg agaacttctg tacaatgcag 1832761 tgttaattgg cctgacaatg gatagagaca cgctttacga aagaattaat cagcgggtcg 1832821 atttgatgat gcagtcaggc cttcttccgg aagtgaaacg cttatacgac aagaacgtga 1832881 gagactgtca atcaatacag gcgataggct ataaagagct gtatgcatat tttgacggtt 1832941 ttgtgacact ttccgatgct gtcgaacagc taaagcagaa ctcgaggcgg tatgcgaaac 1833001 gccagctgac gtggtttcgc aacaaaatgc aggtcacatg gttcgatatg acaccgcctg 1833061 ttgatatgga gctgaaaaaa aaggaaattt tcacacatat agcaggaaaa ctcgaacttt 1833121 aatcgaaact gtatgatata gagaatcaag gaggacgaaa catgaaaccg attaatattc 1833181 aggatcagtt tttgaatcaa atccggaaag aaaatacgta tgtcactgtt tttttgctga 1833241 acggctttca gttgcggggc caggtgaaag gctttgataa ctttaccgta ttgttggaat 1833301 cggaaggtaa gcagcagctt atatataaac atgcgatctc aacgtttgcg ccgcaaaaaa 1833361 acgtccagct tgaactcgaa tagatcaaaa aatgccatgt caagacatga ggaaaggctg 1833421 tcgggggttc ccggcggcca tttttaacat gaatccactt ttgctccaag ctttttgtgt 1833481 aagctgacca tgccaaggca cggtcttttt ttatgagaac aacatacgga agtaaaaatg 1833541 gtatattatg tataaaatga atttgggagt gatcgatctt gtttgaaagt gaagcagaac 1833601 tgagacgaat caggattgca cttgtatgga tagctgtctt tttactgttc ggggcgtgcg 1833661 ggaatcaaga taccattatt gaaacagaca acggcaattc agactatgaa acgcctcagc 1833721 ccacctcgtt tccacttgaa cataaccatt ttggcgttat ggaggacggc tatatcaaaa 1833781 tttatgagta taatgagtcc cgcaatgagg taaagctgaa gaaagaatac gcggatgatg 1833841 agcttgaata aaattcacaa gcattcgaat ttacaaagcg gatgccagcc gctaaactaa 1833901 atacagacac agatcaaaca gagggtgaaa acatgaagca taaagtgatc gtgaatcatt 1833961 gggaagaaat ttgcgaagat gattcttgct atgaatacgg aacaagtatc attgtgaacg 1834021 gaaaagaatt aatcagagaa gcgtcaatta tcactgcttt gaaggcggtt ttagaagaga 1834081 tcggcgcgga tgttgaaata gaagaaacag tagagagcga aaaatgctgt gatagcttaa 1834141 gaaaaaaaaa tctagactac taagcagttt tttttcatgt tatgatatac atcggctaaa 1834201 aacgacaccc cgagtaggac gagagatgat tctcgttctg ctctcttttt tgggccctaa 1834261 tgagtctgcc cgtttgcctg atttgatcaa aatatgaatt tttcataaaa acgaatctat 1834321 atattgtgtt tttgctagag ggtagtatac tatatatagt gttagtgatg agagattcat 1834381 attttttgat aggtcgtgat aaaacgtggt acaaatcata tttgattcga aaacagggaa 1834441 tgttcagcgg tttgtgaata aaacaggctt tcagcagata cgcaaggtgg acgaaatgga 1834501 ccacgtggac actccgtttg ttttggtcac ctacacgaca aacttcggcc aggtaccggc 1834561 atcaacacaa tcatttctcg aaaaatacgc ccatctctta ttgggagtcg ctgcgagcgg 1834621 caacaaagta tggggcgata actttgcaaa aagcgccgat accatttcaa gacaatatca 1834681 ggtgccgatc ttgcacaaat ttgaactcag cggcacatct aaagacgttg aattgtttac 1834741 tcaggaggta gaaagagttg tcacaaaatc aagtgccaaa atggatccag ttaaataacg 1834801 aaatcatgat ccaaaaagat gggaaattcc agtttgataa ggataaagaa gctgtacata 1834861 gctattttgt agattatatc aatcaaaaca cagtcttctt tcacaattta aaagagaagc 1834921 tggattattt ggttgaaaac caatactacg aagaggaatt cttaagcctt tattcttttg 1834981 aagacattaa agaagtgttt aagacagctt acgctaagaa gtttcgtttt ccttccttca 1835041 tgagtgcgtt taaattctat aatgactatg ctttgaaaac gaatgacaag aaaaaaatcc 1835101 tcgagcgtta tgaggaccgg atctcaattg ttgcgctgtt cttcgctaac ggcgacactg 1835161 agaaagcaaa agaatatgta aacctgatga tcaatcaaga atatcagccg agcacaccga 1835221 catttttgaa tgccggcaga aaacgccgcg gtgaacttgt gagctgcttc ttgctcgaag 1835281 ttaatgattc tttaaatgac atttcaagag caatcgatat ctccatgcag ctttctaagc 1835341 ttggtggcgg ggtttctctt aacctgtcca agcttcgcgc gaaaggtgaa gccattaaag 1835401 atgttgagaa tgcgacaaaa ggcgttgtag gcgtcatgaa gcttcttgat aacgcgttcc 1835461 gttacgctga ccaaatggga caaagacaag gctccggcgc ggcgtattta aacattttcc 1835521 accgcgatat caatgatttt cttgatacga aaaagatttc tgcggatgaa gatgtgcgtg 1835581 tcaaaacgct ttcgatcggt gttgtcattc cggataagtt cgttgagctt gcacgcgagg 1835641 acaaagcggc ttatgtattc tacccgcaca cgatttataa agagtacggc cagcacatgg 1835701 atgagatgga catgaacgaa atgtacgaca agtttgtcga caaccctcgg gtgaaaaagg 1835761 aaaaaatcaa cccgcggaaa ctgcttgaaa aattggcgat gcttcgttct gaatcaggct 1835821 atccatacat catgttccaa gataacgtca ataaagtgca tgcgaataac catatttcca 1835881 aggtcaaatt ttctaacctt tgctctgaag tgctgcaggc atctcaagtt tcttcataca 1835941 cagactatga tgaagaagat gaaatcggtc tggatatttc ctgcaacctg ggttcgctta 1836001 acattctcaa tgtcatggag cataaatcaa tcgaaaagac agtcaagctt gcgacagact 1836061 ctttaacaca cgtgtctgaa acaacagaca tccgtaatgc gcctgctgta agacgggcaa 1836121 acaaagcgat gaaatcaatc ggcctcggtg ctatgaacct tcacggctac cttgcgcaaa 1836181 acggcattgc gtatgaaagt ccggaagcgc gtgactttgc aaacacgttc tttatgatgg 1836241 tgaatttcta ctccatccag cgttctgcgg aaatcgcaaa agagaagggc gaaacgtttg 1836301 atcaatatga aggatcaacc tatgcgacag gtgaatactt cgacaaatac gtttcaactg 1836361 atttctcacc gaaatacgaa aaaatcgcta atctgtttga aggtatgcat atcccgacga 1836421 cagaggactg gaaaaagcta aaagcatttg tcgctgaaca cggtatgtat cacagctaca 1836481 gattatgcat tgcgccgaca ggctctatct catacgttca atcaagcacg gcgtctgtta 1836541 tgccgattat ggaacggatt gaagaacgaa catacggcaa ctcaaaaacg tactacccaa 1836601 tgcctgggct tgcatctaat aactggttct tctataaaga agcctacgat atggacatgt 1836661 tcaaggttgt ggatatgatc gccactatcc agcagcacat tgatcaggga atcagcttta 1836721 cattgttctt aaaagacaca atgacgaccc gagatttaaa ccgaatcgat ctgtatgcac 1836781 atcatagagg aattaaaacc atttactatg caagaacgaa agatactggg caagacagct 1836841 gcctttcttg tgttgtttga ttaaaggaga gtttatagtg acaaaaattt atgacgcagc 1836901 aaactggtca aagcatgaag acgattttac ccaaatgttc tataaccaaa acgtgaaaca 1836961 gttctggctt ccggaagaga ttgctttaaa cggcgatctc ctcacatgga agtacctcgg 1837021 aaaaaatgag caggacactt atatgaaggt actggccgga cttacgcttc ttgacacaga 1837081 gcaggggaat acggggatgc cgatcgtggc tgaacacgta gatggccacc agcggaaagc 1837141 ggtgctgaac tttatggcga tgatggagaa cgctgtccat gcgaagtcgt actctaatat 1837201 tttcatgacc cttgcaccga ctgaaacgat caatgaagta tttgaatggg ttaaacaaaa 1837261 taaatatttg cagaaaaaag cgcaaatgat tgtcgggctt tacaaagcca ttcaaaaaga 1837321 tgatgaaatt tcactgttca aagccatggt tgcttccgtc tatctggaaa gcttcctttt 1837381 ctacagcggt ttctattatc cgttatattt ctacggacaa ggaaaactga tgcaaagcgg 1837441 tgagatcatt aacctgatcc ttcgtgacga agcgattcac ggcgtgtatg tcggtctcct 1837501 tgctcaggaa atttataata aacagacaga agagaaaaaa gcagagcttc gtgaatttgc 1837561 gatcgacctc ctgaatcagt tatatgaaaa tgagcttgag tatacagagg acttgtacga 1837621 tcaagtcggg ctctcacatg atgtaaagaa attcatccgc tataatgcga ataaagcgct 1837681 gatgaacctt ggatttgatc catacttcga agaggaagac attaatccga tcgttttaaa 1837741 cggattaaac acaaaaacaa aatcgcatga cttcttctct atgaagggga atggctataa 1837801 aaaagcgaca gttgagccgc tcaaagatga tgacttttat tttgaagatg aaaaagagca 1837861 gatataatat ctgctctttt cggcttgaag gttcaaatga ggaggacgca gtacccatgg 1837921 gaaaaatgga cgaaatgatt ttagttgccc cgcgcgatga tgtgtttaaa aaagaaagct 1837981 taaccttcca gggcgtgtac agtgaagata gcagagtagc agaaatcatg gctcagattg 1838041 aagcggccta tcgtgaaatg agaagagggg acgcagaaga agatccgcgt ttcaagcagc 1838101 cgatacctta tgtcgtcatt aagcgtgaag atgaagtttt tctttacgag cggctggctg 1838161 gcggcggtga atcacgtctg cacaacaagc tttctctcgg ttttggcggc catatgaacg 1838221 ccatcgaagg ggcagcttca tttgctgaag tcttaaagct gaacacagac cgtgagcttg 1838281 aggaagaact gcaaataaat gaagaagata aacaggcgat tgtcacactg ggattgatca 1838341 atgatgatga aaacagtgtt ggcaaagtgc atatcggtat tctttctgcg cttcaattaa 1838401 agcctggcgc acaagtggaa gtgaaggaga aagaacaaat tgcgggtaaa tggatgaaag 1838461 tttctgaatt aaaacaggat gatatctaca accgtctgga aacatggtca cagtttgttg 1838521 ttgatattct tgaataaaaa aacccggttt ctcgcgatga ggagccgggt ttttttatga 1838581 gacgctcgtc cccgtctcgg ctatgattct aggatcacaa tagcgtcaaa gccggcattt 1838641 ttcgctctgg cagcgagggt gtctgcattg tctttggatg aaaatgcgcc aatctgcact 1838701 ttgtataatc cgtcctttaa aaggacaatc gagtcaaaac ctttggcttc ggcattactt 1838761 gcgagcgagt cggcattcgc tttgacttta aatgcgccga tttgaacctt atataaccct 1838821 gagctggaag tctttttaag gttaaaggct tgctccagcc cgtttgcatg tcctctcgct 1838881 aagctttgaa taaaactgct cgttttcagc ttatttgcat cggaaacggt atcaatgaag 1838941 ccgttctcgg tcaagagggc aggcattgcc gactccctta ggacgtggaa gttcgctgtt 1839001 tttttgccgc gatcggcaaa gtcgacagct tgtatcactt cagagtgaat tgtcgattga 1839061 taagtcgtcg tcggggctcc tacatctgga taaatatagc tttcaaaacc tgtgcctccc 1839121 ccggaattaa cgtgaatgga caaaaagaaa tctgctcccc agttatttgc ggcatttgtc 1839181 cggtcgttta agctgacata ttggtcgctt gtccggctca gcagcagaga aacgccttca 1839241 tattcattag ttaatatcgt acgtaaggct aaagcgattt gcagggttaa cgttttctcc 1839301 tgaaggccat tacctgttgc gcctggatca gacccgccat ggccaggatc aataaaaatt 1839361 ttaaccattt ttcatcacct cattacagga tatgaaaaaa cacggcttct gcttgtacga 1839421 ttatcattca actgaaaaat gaggaaataa ccctttcaca tccagaaatt atttctcggg 1839481 aaagcgcaca attcaacatg aagcgacaac agatacggtc cgacatgaaa tctgtgcata 1839541 cgccatatgt ttgtatgtac tatgggttcg gttaacctgc actgattcct gctggtttta 1839601 agctttgcgt tcatattaaa tcaagcattt aaaacgtaaa ttgatgagga aagctccttt 1839661 cattaaagac accgctttat aaatcgaaaa aaagaaaaac acttcaggta tcttagggcg 1839721 ggtaatacgt ttcgtacaaa aatcagcccg ttgtatgaaa aagaaataat gagaaagaag 1839781 ctcactataa tactctgaca aaatgattaa aaacaaaatc tcatggtttg tccaccccat 1839841 gtccgtgaat acaataagaa ataaagtatt tctcgggaaa gcgcaggatt ccttattgtt 1839901 cccgaaaaaa gcaattgttt cgacacatga taggcgtttg tcacaatcgg catccgcttg 1839961 aatatcatat agagagaaca gagaggtgaa gatgttggag cgcgctgtga cttataaaaa 1840021 caacggacag atcaacatta ttctgaacgg gcaaaagcag gtgctgacga atgctgaggc 1840081 agaggcggaa tatcaggctg cattgcaaaa aaacgaagca aagcacggca ttttgaagga 1840141 aatcgaaaaa gagatgagcg cattagttgg gatggaggaa atgaaacgca acatcaagga 1840201 aatatacgcc tggatttttg tgaaccaaaa acgcgcggag caaggcttga aggttggaaa 1840261 gcaagcgctg cacatgatgt ttaaaggaaa tccgggaacg ggaaaaacga cggttgcacg 1840321 gctcatcggc aagctgttct ttgaaatgaa tgtcctgtca aaaggccact taatagaagc 1840381 ggagcgggct gacctggtcg gggagtatat cggacacacc gcccaaaaga cgagagattt 1840441 aatcaaaaag tcattaggtg gcattttgtt tatagacgaa gcctactcgc tggcaagagg 1840501 cggcgaaaag gactttggga aagaagcgat cgacacactt gtaaagcata tggaagacaa 1840561 acagcatgag tttattttga tactcgccgg atattcacgg gaaatggatc attttctctc 1840621 gttaaatccc ggactccaat caagatttcc catctccatt gattttccgg attactctgt 1840681 gacccagctc atggagattg cgaaacgaat gatcgatgaa agggaatacc agctcagtca 1840741 agaagcggaa tggaaattga aagattactt aatgacagtg aaaagcacga caagtcccat 1840801 taaattcagc aatggacgtt ttgtcagaaa tgtgatcgaa aaatcgatca gagcacaagc 1840861 catgaggctt ttaatgggag accaatactt aaaaagcgac ttgatgacca tcaaaagcca 1840921 agatctttcc attaaagaag aagcatctgg atctgcatag acctctcagt ttttgagagg 1840981 tctgtttttt gctcgtattt ccgcttttca aagcaatcga tttgtggtat acacatgcag 1841041 ggtttggtat gataatacta ctgcccaata tgcaaaagaa aggaacatcc atttgaacga 1841101 acaagaaacg attcaggaga aagccatttt agtcggatgt cagctgccgc atatcacgga 1841161 tgagcatttt gaaaattcta tggaagagct agcatctctg acgaaaacag cagacggaaa 1841221 agtactgacc agcgtcacac aaaaacggaa cagggctgac gccgctacat atataggaaa 1841281 agggaaggta gaagagctga aggcactcgt ggaagagctt gaagctgatc tcctcatctt 1841341 taatgatgaa ctgtcgccaa gtcagctgaa gtcattggca acagcaattg aagtgaagat 1841401 gattgaccgc acgcaattga tattagatat ttttgcaaag cgggcgagaa cgagagaagg 1841461 caaacttcaa attgagctgg ctcagctgca atatgcactg ccgcgtctga cgggacaagg 1841521 gatcaacctt tcccggcaag gcggaggaat tggggcaaga ggtcccgggg aaacgaaact 1841581 ggaaaccgac cgccgccata tcagaaatcg cattcatgaa atcaacacac agctttccac 1841641 tgtcattcgc catagaagcc gataccgtga aagaagaaag aaaaacggtg tgcttcaaat 1841701 tgcgcttgtc ggctatacaa acgcagggaa atcaacatgg ttcaaccgcc tgacgagtgc 1841761 tgacagctat gaagaagacc tcctgtttgc cacgctggac ccgatgacca gaaaaatggt 1841821 cctgccaagc ggctacagtg ttcttctttc agatacagta ggatttattc aggatcttcc 1841881 gacgacattg attgctgcat tccgctcaac gcttgaggaa gtaaaagaag cggatttaat 1841941 tctgcattta attgattctt caaatgagga ttatgcggga catgaaaaaa cagtgcttcg 1842001 gctgcttgag gagcttgaag cagatgatat cccgatgctg acggcttaca ataaacgtga 1842061 tcaaaaactg cctgatttta taccgaccgc cggaagggat cacattatgg tcagtgcgaa 1842121 atttgaggac gacgctgcag cctttaaaga agcgattcag cgctatttgc gccaagaact 1842181 gttaacgtct tttgaagcac atgtgccggc aagtgaaggg aagctccttt ccagaatcaa 1842241 atcggaaacg atggtagacc gcttctattt taatgaagaa aatgaacagt atgacatatc 1842301 cggctatgtc caagaagagc aaagtatcat cggtgaatta aagaagtata tgtaggaagg 1842361 aaatataaag acatgtttga cacattaaca cacggagaat tattgaagaa aacggcaatg 1842421 gaagtggaag cggacattgc cggcattcat aaacaaatag aagaaatcag cgagcgaaat 1842481 gagtggagag tgcttcaaag ctatagaaaa cacaaagtaa gcgacactca tttcacgccg 1842541 tctactggat acggctatga tgatatcgga agagacacgc ttgaaagcat atatgcggat 1842601 gtgtttggcg gagaagcggg gcttgtaagg ccgcaaatca tttcaggcac acatgccatc 1842661 tcaattgctt tgttcggtgt cctcagaccg ggggacgagc tcctttatat cacgggcaag 1842721 ccgtatgata cgctagagga aattgtgggc gtcaggggtg gagaaaacgc tggttcgtta 1842781 aaggattttc aaatcggcta taatgcggtt gatctgacga aagacggaaa gatagactat 1842841 gatgcagtcg ccgctgcgat caatccgaag acaaaagtaa tcggcattca gcgctcaaaa 1842901 ggatatgcga atcgcccttc tttcttaatt agtgaaataa aagaaatgat ccgttttgta 1842961 aaagaaatca atgaaaatct gatcgtcttt gtggacaact gttacggaga atttgtggaa 1843021 gagcttgagc cttgccatgt cggagccgac ctgatggcgg gatctctcat taaaaatccc 1843081 ggcggcggcc ttgcgaaaac aggcggctac ctcgtcggaa aagcgaaatg gattgaagct 1843141 tgctcatacc gtatgacgtc acccggcatc ggcagagaag cgggggcatc tctttactcg 1843201 ctccaagaaa tgtaccaagg cttctttttg gcgcctcacg ttgtgtctca aagtttaaag 1843261 ggagcggtgt ttacagcgag attccttgaa aaactcggct tcacttcaaa cccgaaatgg 1843321 gatgcgaaaa gaacggattt aatacaatcc gttgagtttt ctgacagaga aaagatgatt 1843381 gctttttgcc aggctattca atttgcatcg ccaatcaatg ctcatgtgac gccttatcca 1843441 gcctacatgc ctggatacga ggatgatgtc attatggcag cagggacgtt tattcaagga 1843501 gcaagcatcg aattatcagc tgatggccct atccgcccgc cgtatgtagc gtatgttcag 1843561 ggaggattaa cctattcgca tgtgaagaat gccatatgca gtgcagtgga ttcattgatg 1843621 caaaagcaat taatttaaat tttttaaaaa tttctctgga tttgatgtta agaatcctta 1843681 catcgtattg acacataata taacatcacc tataatgaaa ctaagttaag aaaaggagga 1843741 aattgagatg agtgataata ttcgccgctc aatgccttta tttccaatag gaattgtcat 1843801 gcagttaact gagttatcag caagacaaat tcgatattat gaggaaaatg gactgatatt 1843861 tccagccaga agtgaaggaa atagacgatt attttcattt catgatgtag ataaactgtt 1843921 agaaatcaag cacctgatag aacaaggtgt aaacatggca ggaattaaac agattctggc 1843981 gaaagccgaa gccgagccag aacaaaaaca aaacgagaag acgaaaaaac caatgaaaca 1844041 tgatctgtcc gatgacgaac tgagacagct cctgaaaaac gagctcatgc aagccggccg 1844101 ttttcaaaga gggaatacat tccgtcaagg cgacatgtcc cgcttctttc attaatccgt 1844161 tagcaactgt tttgctatat acatttacct tttaagagga ggaattttac caaatggcaa 1844221 agtacactag agaagatatc gaaaaattag taaaagaaga aaacgtgaag tatatccgcc 1844281 ttcaatttac tgacattctt ggaacaatca agaatgttga gattcctgta agccagcttg 1844341 gaaaagcgct tgataataaa gtcatgtttg acggttcttc tattgaggga ttcgttcgta 1844401 tcgaagagtc agacatgtac ctgtatccag atctaaatac atttgttatc ttcccatgga 1844461 cagctgaaaa aggtaaagta gcacgtttca tctgtgatat ttacaatccg gatggcacac 1844521 cttttgaagg tgacccgcga aacaacttaa aacggattct gaaagaaatg gaagacctcg 1844581 gcttcagtga ttttaacctt gggcctgagc ctgaattctt cttattcaaa ttggacgaaa 1844641 aaggcgagcc gacgcttgaa ctaaacgaca aaggcggata tttcgactta gctccaactg 1844701 atttaggaga aaactgccgc cgcgatatcg tacttgagct tgaagagatg ggctttgaaa 1844761 tcgaagcgtc tcaccacgaa gtagcacctg gtcagcacga aatcgacttt aaatatgctg 1844821 gagcagtccg ctcttgtgat gacatccaaa catttaaact agttgtcaaa acaattgccc 1844881 gtaaacacgg cctgcatgcg acatttatgc caaaaccatt gttcggtgta aacggttcag 1844941 gtatgcactg caatctatca ctcttcaaaa atggtgttaa cgcattcttt gacgaaaacg 1845001 cagatcttca gttaagtgaa acagcgaagc acttcattgc aggtatcgtg aagcacgcaa 1845061 caagctttac agcagtaaca aacccgacag taaactctta caaacgtctt gttcctggct 1845121 atgaagcacc ttgttatgta gcatggagcg cgcaaaacag aagcccgctt atccgtatcc 1845181 cggcttctcg cggcatcagc acacgtgttg aagtacgcag tgtagaccca gctgcaaacc 1845241 cataccttgc acttagcgta ttgcttgctg caggattaga cggaatcaaa aacaaactgg 1845301 aagcgccggc tccaatcgac cgcaacatct atgtgatgag caaagaagag cgcatggaaa 1845361 acggaatcgt tgaccttcca gcaacacttg cggaagcact agaagaattc aaatcaaacg 1845421 aagtcatggt caaagcgctg ggcgagcacc tattcgaaca cttcatcgaa gcaaaagaaa 1845481 tcgaatggga tatgttccgc acgcaagtac atccttggga acgcgaacag tatatgtctc 1845541 agtattaata tctcaatccc ttggcactaa aagtgtcagg ggatttttta tgttaatagg 1845601 taataaatta tggagcggca ctgctaaaaa gcagggtcac ttttagtcta tgtcactaat 1845661 aattctatgt actaaatttt taattaggga aataattcca cgcttaagga agcaatacgc 1845721 ataaataatt cgacaaattc tgtgataatt ccattgttca atacttctac cagcaataat 1845781 aagatgagta aggtagatgt ttatcattga catcataacc aaatgaatcc ataattacgt 1845841 tgaaatctaa atcaattttc aaaaaggaga tttctatgaa aaaattgact atcttctccg 1845901 ggggattagg agcggttttt tctgtactgg ctcaactgtt tgcggttata gatgactctt 1845961 acactttggg gaatttatgg tttttaggtg ctttggcggg aattataacc atgcttgctt 1846021 caatccagac aaataataaa ccagtcttca gcatattatt aattgctagt tcagtaatag 1846081 gtctacttgg aactggtctt gtatacatca taccaacact gttcaatata ataataattt 1846141 ataaattttc aaaagtaagc caataagcca atgggaaaat taaggttctt tttttattta 1846201 acatcccttt gacaaggtcg gtgataaatc gcagaatgtt tatgcttgca actaatccac 1846261 cagcgggggc atcggtgggc atgattatct aacgccatgt ttctaggata ccggaattga 1846321 aacatttgct gaggcatttc gtgaagctga tcaccaaatg accatttcca tagaggcacg 1846381 tctaaagaag ctatcatagg aggacaatac tgtgtggaaa gctttaagtc aattactcaa 1846441 gaaacagaaa aatcaaagtc caagcgatga agattatata cagattccag aattagaagt 1846501 aaaagttttg gggatgcttc acagtatcaa tatagacctg gttaatgtaa tagcccaagc 1846561 agaaaagtct aaggagttta taggacaaat cgaaggcatc tggcattcta tagcaaatca 1846621 attttattca ctcgcccaag ggtttgagaa tgaggatatc aataagcttt ctgcggatct 1846681 tgatcatgct gccgccactt gggaagctgt tgctaataaa gcaaaagagt ttgtaacaaa 1846741 ttcataccaa gggtaaaaga aaaataaggg cctgaaaggg ctcttttgct tatagtcata 1846801 tttcccgtaa gtattacttt ttggatttaa taaattttaa agcgtgtttg tttcactgaa 1846861 ttcatagtca aaaggggaat gtttttatgc ttggaatcaa cgttgaaaaa tcaaatgaaa 1846921 acttaattat caattggcag ctatccaaaa ttgaaattcc aatcaaagaa atcaatgatg 1846981 tatttcttga tccaaactat gggggagagg agaaaagcgc agtaaggatt gggtttcctt 1847041 atggctcaac agatagggta gtaattaaaa cagcacgtaa cacttacatt ttgttcacca 1847101 ctaatcctgc tttaattatg agtaaaattg tttcttaata aacagtttat gtccctttta 1847161 aatttatcta ttaatgttct gtgtggtaaa atttagtgag atgatttaag gaggaggagc 1847221 atttatggaa gaaataaaag ttagttcaca tgacactaga tggtattaag aaagcagttt 1847281 ctaaatatgg tacattccct atgtttcatc atggaggata tgtcatggaa gatgctactt 1847341 ttcatttcaa agatcctgct agtcctcaag aaattagcga tatagaacag aagctaggtg 1847401 ttactttccc taatgactat aaagagtttt tgttacagca caatgggatg gaaatgtttg 1847461 atgggattga aatacttagc ttagagggaa tcattgaata taatgaggtt caagatttcc 1847521 cagagggata cgttttaatt ggatatcatt ttgatggaag atatgtcata gacacaaaca 1847581 aatcaaaaaa tggattaggc tatatgctat atctagactc aattgatgat attgaagatg 1847641 cgattaactt agattctaat ttcgagatat ggtttgatat gctagtgtct ttaaatggaa 1847701 cgaaatattg ggaagtaaat ccgaatctcc aagagtatta taaactggtt tcagaataac 1847761 acttcggcaa aagaaaaaat tatgactaat ttcaacaacc aaagaaactg caatttgagg 1847821 gaagtataat gacaatttac gagcaaatta aggatgcttt gaaaaataag atcaatgagt 1847881 tggtttcacc tcaagaagta aagaaaaccc ttcaagaaaa atacggaact aatccggata 1847941 gcattatttt atcagattat tgttataacc ggtataataa ggggatttct tttaataagc 1848001 acctctttga atatatgaat agaagttctt acaaatactt aggtgaaaac tctctttata 1848061 caggacttat tttcagaaaa tcaaaagggg aagataagga agttatcgta ggcgaatggg 1848121 taaacggtgt taaatcactc cgagaagctt ctgttactaa taaccaaata aatgatcaag 1848181 ccgaaatcat tagtaaagaa caacttgtaa acctttataa tgaatataac caaatcctga 1848241 gatatgaaat gaatgtattg aactgtaagc ctacagaatt gaggcattta attggcagaa 1848301 tcggtgaatt catttgtgca atccaaacca acggcactct ggcacgtcaa actaatcagc 1848361 atggatttga tgttgtgagt gatggcagac ggattagtgt aaaaacaaca gctcaatcaa 1848421 gtggttttat ttcgataaat aaaaatacat tttatgattt tgatgatttt tttgtagttc 1848481 aatacgtaaa tgatgatttt aaagttattt tcttcggctc aaaggaagaa gtgcaaaaaa 1848541 taagcagaat ttatggaagc caatacgaag ttgaaatttc acttcttaaa aagcttaata 1848601 aggaatacca attaaattaa acaatcttgt tggtaacaaa catcctctta cttattgtaa 1848661 gaggatgttt gtttaattct tacatatttt atctttgcaa tctggcttac gagttgcatc 1848721 cacagtaaat gatcttactt cgtctttagt tttgtcataa attccccata ttacccctca 1848781 gagaaggata gggggattat tttggagaat catattccat tgcttgttca cagtcagtaa 1848841 tccttgagtt gttctagcaa gaggcaatat tgttgaataa gaatagtttt aaagaggtta 1848901 ttgttgtctt catattgaaa taaagattaa gtatattaga ggggagttgc tttaatgcac 1848961 ataacaacaa aaaggttatt gatacgtgaa tttgaattca aagattggca agcagtatat 1849021 gagtatacat ctgatagtaa tgtaatgaag tatatacctg aaggggtttt tactgaagaa 1849081 gatgcaaagg catttgtaaa taaaaacaaa ggtgataacg ctgaaaaatt ccctgtcata 1849141 ctaagagatg aagactgtct tataggccat attgtttttt ataagtattt tggtgaacat 1849201 acatatgaaa ttgggtgggt gtttaatccc aattatcaaa ataaagggta tgcttctgag 1849261 gcagcccaag ctatcttgga atatggattt aaagaaatga acttacatag gattatagct 1849321 acgtgtcaac ctgagaatat tccctcatac cgagttatga agaagattgg aatgagaaga 1849381 gaaggctttt ttaaaaaatg tattccaaaa ggcaatgaat ggtgggatga atattattac 1849441 gctattttag aggaagagtg gaattgaact ttattgagtg cggcaataca aacaaattat 1849501 caccctctac ttagaacata ttagttaaat gaaggtgata tataaagtga tatgacagtg 1849561 attaaatggg attcaatgag ctccggtgaa ttgtttttag gtgagttcac taaggatgat 1849621 acctgatacg cagccatacc attcgagcgt taatcatttt ataactgatc ttttcacttt 1849681 tgcccacggg ggaataagac cctatttaag tttgccagac gattgtttga tccgttgttg 1849741 atgattgtca ggattttttg tgaaggaata tctttatata gtggttgatt attcccttct 1849801 ggtaaaaatt gatctatgtt gaattgctta acatgtcatt gaactcagag aataaagtga 1849861 acctgccaca gatgttcatt atcttttagg gggttccaaa aagaccgtat tcctatcgat 1849921 cgctcagagt gaaaatggta tactaaagtt acaatcacag gaaggaatta caattttttt 1849981 agatctacat aaaatcatct gattaaccga aagtgagaat gtgtgaatga atttaatagg 1850041 gtatattgag gaaaggtttc aaaacctcga attaattcct agcatctata atcaatgggg 1850101 cacaggaatc catttttgtc ttggggaaaa tatctatcaa ctcaaagcaa atgaagaatt 1850161 gaatttaaag atgtttcgga ttgtatatga acaaacctca atcattttta atgaattatt 1850221 tgaacaaaat gatgacatat tccttgtgac gaatatgtat aagcacaaaa agaaagagaa 1850281 atgtataaga aaattaaagg tgtatcaacc gtttctaaaa tgtaaaaatc atttgaatca 1850341 aattatggtg aagacatatc cctatccttt cgaaatcaat aaagctgaag aatacgagat 1850401 gcaacaattt tccctgttat gcaaacctcg agacttacgt gtaactgaat tacttaaagc 1850461 agccagtaat gaggattttc cacaaaaacc gaaattcgga ggttactcta ttgattaccc 1850521 tgatgttttc tttgtgaaca ttacaaaaga cattattttc tttatctatg atgaccgcgg 1850581 atgcgaagtc atagctcatg atttcaaacg aatacgtcca ctttatgaaa aatatcacga 1850641 ctgggtagaa gagtataagt gcatgtaata ctttttttaa aaacgattta tcaggaaagg 1850701 cagaattaga ttatgagggc cttacataca agatgtaaac ggttattgaa actaagatgg 1850761 tattatgtga tgatgagaga tctgcatttt tattagtact tgatgaaaga ttagtggatt 1850821 ttgattctca aggtggaaac catattagtg tttatttagt tactcacttt gagttatctg 1850881 atcaatcgta taaagatgta ttaagcttta atgatgatct tttgggtatg gagcataact 1850941 gttcgtatgc aatggatatt ctaagcgtta aagaggaact tgatttcgat ttcccattta 1851001 atatgcttgc aataaaaagc tatgtacaag aattaataaa aatgttaggg attgatatca 1851061 ctctgcctga aatgaaagaa agagattttg acaaactttc tcaaaactaa ataaaactac 1851121 tatttttaaa gagaacggag acttgctttc aatatgaatg ttaaaaaagc tgcagctgtt 1851181 ttttcaatca ctattccaat tatctcagcc atcttaatta ttaatttttt tacaggattt 1851241 atgtcaattc catggcaagg aatgccggtg ttttttccat tattactttc tcctatagga 1851301 atcattttag cgttcgtttc aataaagaca aataaacggt gtgctgtata tgggattgtc 1851361 ttaaatgcaa ttatgtttcc atttcctttt ttctggttta tcggaggggc tttgttattt 1851421 ggagtttaaa atccattagg cattacgctt atacattggt attttcgagc ttgtcaaaag 1851481 aaggaataaa aaaacttcag aattgcttgg ctttacttta tgttgaaagg ggtcgagtaa 1851541 ggtggatagg aaaaaggatg aaatacaaag aaaatatagg gaacaaatga gggagaagaa 1851601 agaacgagaa aaagaagatg gcagttcaca tacttttgaa attgttgttg tgctagccat 1851661 tatcattttg atgtttttct ttaattcagt tttcaaggct ttttagatat tgtacagatg 1851721 actttcagga tgtttgaaaa aataaccctt tgagatatat accgcatgaa agtattgaag 1851781 gacttatgaa aattcaagag ccagttgaat cttaataatt aatcaccaaa taatggggat 1851841 gtaaaatgaa gttgtataat gaatttatca atatagctaa aacgtttaat aaagagttag 1851901 acataattcc attattatat ggatctttag gtcttgaaaa ggtaactggg ttagactttt 1851961 ccccagaaga tattgatctc cttattcctt taattttttt agaggaaaag tgggaaaaac 1852021 taaaaaaagt gatggaactg catggataca aaatggttga tttacatgag catgaattta 1852081 agaaaactaa tacaaaaata ggcatttctt acattgagga tttaaaacca tttgcagatg 1852141 tagactataa taacctagag atttttgaag atggcggagc gaaatatcat ttgctaacga 1852201 ttgatgatta cctcaagatt tataaaaagt ctttattaga tggttataga agaaggaaga 1852261 agaatcataa agaccaaagt aaaattaaca tattgaataa attaatacgg aattaatttc 1852321 tgtattccct tttgtttcca gtctcaatta aaatttttaa gattaaaata agtttgaagg 1852381 aaaaatcata gtgtttaaca cagccattaa tcctcagaca gtcaaatagc catttctact 1852441 ccggttgaaa gcttctctat ttttgcttct tatttatctt tcctgtattg atatatgtat 1852501 gtagggttgg acttataaca taaactattc tggccattcc gttctttcaa ttcatgaccg 1852561 ggcttgccat cagcataaat ctaggctaac agtctccata catcctgtga tcacctttat 1852621 caaactctta aatgcaactt accactaacc aattctttat ttcgcataga tcatctttgt 1852681 catgtgttta cacaagaatc tgttttggac tgagacactg aatataacaa aacagtcaaa 1852741 aatcaatatt taattcattc tgtttaaact ttctgaaaaa gatgttgaaa aagtcgaaag 1852801 gattttataa tattaagtca agttagtttg tttgatcaac aaactaatga aatgaacttt 1852861 cattatccac aagataagat cttactaata tggatggaag ggggataaga gggtcgattt 1852921 aatggagcta aacaatataa gaaacgaaag aatgaggctt ttatcctttt ccaggtatat 1852981 aaggtatgac gaaaaaagat gaattttttg cttgctgatc accatatttt tttgcactgt 1853041 tttgaaagcg cttttataaa agtttactga ccgtaaattc gagaaattgt tataccgttt 1853101 cacactgttc catattaaag gatcgaaaag gggagaaatc atgctcagtg aaaatgtaaa 1853161 gaagattagc atggttgaaa aagttggata tgcgtctgga gattttgctt gtaatttaat 1853221 ttatgcaaca gtgtctacgt atcttttgtt cttctataca gatgtttttg gtttatcggc 1853281 agcagcagcc ggtactatgt ttttagtggt tagaataatc gacgctctcg ctgatccttt 1853341 tatcggaaca atagttgaca gaacgaacag cagatttgga cgctttagac cgtatctttt 1853401 attcggagct tttccatttg tcatactggc aatactctgt tttacaacac cagacttttc 1853461 ggatatgggg aaattaatat atgcctatat aacctatgtt ggcttgtcgc ttacatacac 1853521 aacgataaac gttccatatg gcgcgttaac ttctgcaatg actagaaata atcaagaagt 1853581 tgttagtata acttctgttc gcatgttatt tgcgaatctt gggggacttg tcgttgcatt 1853641 ttttgttccc ttactggctg cttatttaag cgatacttcc ggcaacgagt ctcttggctg 1853701 gcaactaacc atgggtattt tgggaatgat aggcgggtgc cttttaatct tttgttttaa 1853761 aagcacaaaa gagcgggtca ctcttcaaaa atccgaagag aaaattaaat ttacggatat 1853821 atttgagcag tttcgtgtta atcgtccact tgttgtatta agtattttct ttattattat 1853881 ttttggagtg aattccatca gtaattcggt tggcatttac tacgtaacgt ataacttaga 1853941 aagagaggat ttggtgaagt ggtacggttt gataggaagt ttacccgctt tggtcatttt 1854001 accgtttatt ccaaggcttc atcaattttt ggggaaaaag aaattactaa actatgcatt 1854061 attactgaat attataggcc tcttagcttt actgtttgtt ccgccaagta atgtttacct 1854121 catacttgtc tgtcgattaa tcgctgctgc tggaagtctc actgccgggg gatatatgtg 1854181 ggcgcttatt cctgaaacaa ttgaatatgg agagtacagg actgggaaaa gaatgggtgg 1854241 gctcatttac gctataatcg gatttttctt taagtttggt atggccttag gaggagttgt 1854301 tccgggtctg gttcttgata agtttggata tgtagcaaat caggcacaaa ccccggcggc 1854361 cttaatgggg attttaatta caacaaccat tattcccgtg ttcttgcttg ttctagcttt 1854421 aattgatatt aatttctata acttagatga gaaaaaatat aaaaacatgg ttcgagaatt 1854481 agagaataga gacaaagttt atttggatca tattgatgat ttcaaggctt aaaaaagaaa 1854541 ataaactgag gaggagtccc aaatgaagat taccaatccc gtacttaaag gattcaatcc 1854601 cgatccaagt atttgtagag caggagagga ttattatatc gctgtatcta catttgagtg 1854661 gtttccggga gtccagatac accactcaaa agatttagta aattggcact tagttgcaca 1854721 tccattacag agagtttcac aattagacat gaaaggaaac ccaaattcag gtggagtttg 1854781 ggcaccatgt ttaagctata gtgatgggaa gttttggctg atctatacgg atgttaaggt 1854841 agtagatggc gcatggaaag attgtcacaa ttatttagtt acttgtgaaa cgattaatgg 1854901 tgattggagt gagccgatta aattaaatag ctcggggttt gatgcttctt tgttccatga 1854961 tacggatgga aaaaagtatt tattaaatat gttatgggat caccgtattg atcggcactc 1855021 atttggagga attgttatac aggaatattc tgataaagag caaaaattaa tcggtaaacc 1855081 aaaagttata tttgaaggaa ctgatagaaa actgacagaa gctccgcatc tttatcatat 1855141 cgggaactat tattatttat taactgcaga aggaggaaca cggtacgaac atgctgctac 1855201 aattgctcgt tctgcaaata ttgaggggcc atatgaagtt catcccgata atccaatttt 1855261 aacgtcatgg catgacccag gaaatccatt gcaaaaatgt ggtcatgcat ccattgttca 1855321 aacacataca gatgagtggt atttagctca tttaacggga cgtcctattc atcctgacga 1855381 tgattcaatt tttcagcaga gaggatactg tcctttgggc agagaaacag ctattcaaaa 1855441 actttactgg aaagatgaat ggccctatgt agtaggtgga aaagaaggaa gcttggaggt 1855501 agatgcacct tctatacccg aaacaatatt tgaagcaacg tacccggaag ttgatgaatt 1855561 tgaggattca acattaaata taaattttca aactttaagg attccattca cgaatgaatt 1855621 aggttcattg actcaagcgc caaatcattt acgattattc ggtcatgaat cattgacctc 1855681 gacatttact caggcatttg tagccagacg ctggcaaagt ctccattttg aagccgaaac 1855741 tgctgttgag ttttatccgg aaaattttca acaagccgct gggttggtga attactacaa 1855801 tacagagaac tggacggctc ttcaagtcac gcatgatgaa gaacttgggc gcattcttga 1855861 attaacaata tgtgacaact tttctttttc acagccatta aataataaaa ttgttattcc 1855921 tcgtgaagta aagtatgtat atttaagagt aaatattgaa aaggacaaat attattattt 1855981 ctattctttt aacaaagaag attggcacaa aattgacatt gcactggaat cgaaaaaatt 1856041 atcagatgat tatatccgtg ggggaggatt cttcacaggg gcctttgtag ggatgcaatg 1856101 ccaagatacc agtggtaatc atattccggc cgactttaga tattttcgtt ataaagaaaa 1856161 ataatttgca catgaaaaag gagatttcta ttttagaact cctttttcat atgagaaggt 1856221 gccatgtcac tattgcttca gaaatactcc tagaataaaa aaactcatct ttaaagatga 1856281 gctgtccatt ccataaaaaa ttacattgta atcatgtcca gaaaatgatc aatcacaatg 1856341 gaggacattc ctaatgccgg tgcattctgt cctaaggaag atggcaataa ttcatagcta 1856401 ttgcctaatt gggaataaac ccttgatgat acttcacttc tcattgaatt taaaaccata 1856461 ggatgcgatt caattatgct atttcttaaa attacggctt gtgggttgaa agtatttaga 1856521 atattggtaa ggcctattcc taaatagaat ccaaaatttt gtaatgcatt taaggttccg 1856581 atatcattca gatgggcgag gtttatgata tcttgatagg acagtttttt ctctttggtc 1856641 tgaagagatt ttaataaagc cttctctgaa gcatacaatt cccagcatcc tcggtttccg 1856701 caactgcatt taggaccatt aaagtctatt gtcatatgtc ccatttctcc agagaagccg 1856761 cttactcctc tatataaatg attgttgata ataacaccga tccctattcc tgtgctgata 1856821 cttacgtaaa taatgttatc gtgatttttt gcagctccaa atactttttc tccatatgcg 1856881 ccagcatttg cctcattttc aataaaaaca ggcacattgt acttctcttg tatcgaagat 1856941 tttaagtcaa tatctctcca gttggagttc ggagtgaaaa caattttttg atctttatca 1857001 atgagtccag gcacgcaaat acctatacca ataagcccgt acggagattg gggcatttgc 1857061 gtaataaagt gatgaatcat atcaatcaaa atgtctttcg ttatttctgg agaattggat 1857121 tccaaatggc ggtattgatc aagaacgatt gttccttcaa ggtctgttaa aatgccatta 1857181 atataatcca caccaacatc tattccaacg gagtatcctg cctttttatt aaaaacaagc 1857241 atgacaggtc ttcttccgcc acttgattgt ccttgaccta tttcaaatac catactttct 1857301 ttcattaacg tgtttacctg tgatgagaca gttgatttat ttaatccagt catttcagat 1857361 aattttgctc ttgaaatagg tgaattttta aggatttctt ttaataataa cttttgattt 1857421 acttttttga caaaggtttg atcagcgata tccacttcat ccactccatt tgtttaatct 1857481 ttaaattaag tatcaacata gtacatagcg aatcttccct ttattatatc taatgtgttc 1857541 ataaaaaact aaaaaaaata ttgaaaatac tgacgaggtt atataagatg aaaataagtt 1857601 agtttgttta aacaacaaac taataggtga tgtacttact atatgaaata aaatgcatct 1857661 gtatttgaat gaatttattt ttaaggggga aatcacatgg ctcaatctca ttccagttca 1857721 atcaactatt ttggaagcgc aaacaaagtg gtttacgaag ggaaagattc gactaatcct 1857781 ttagcattta aatattataa tcctcaagaa gtaatcggcg gaaaaacgct gaaagagcat 1857841 ttgcgatttt ctattgccta ttggcataca tttactgctg atggtacaga cgtttttgga 1857901 gcagctacga tgcaaagacc atgggatcac tataaaggca tggatctagc gaagatgaga 1857961 gtagaagcag catttgagat gtttgaaaaa ctagatgcac cattctttgc ttttcatgac 1858021 cgggatattg caccagaagg cagtacgcta aaagagacaa accaaaattt agatatgatc 1858081 atgggcatga ttaaagatta catgagaaat agcggcgtta agctattatg gaatacagca 1858141 aacatgttta cgaatccccg tttcgtccat ggtgccgcga cttcttgcaa tgcagatgtg 1858201 tttgcgtatg ctgcagcaca agtgaaaaaa gggttagaaa cagcaaaaga gcttggcgct 1858261 gagaactatg tattttgggg cggccgtgaa ggatatgaaa cattgttaaa taccgattta 1858321 aaatttgagc ttgataattt ggctagattt atgcatatgg cagtggatta tgcgaaggaa 1858381 atcgggtaca cagggcagtt tttgattgag ccaaaaccaa aagagccgac cacccatcaa 1858441 tacgatacag atgcagcaac aaccattgcc tttttgaagc aatatggctt agacaatcat 1858501 tttaaattaa atcttgaagc caatcatgcc acattagccg ggcatacatt cgaacatgaa 1858561 ttacgcatgg caagagtaca tggtctgctt ggctctgttg acgcaaacca gggtcatcct 1858621 cttttaggct gggacacgga tgaatttccg acggatttat attctacgac attagcaatg 1858681 tacgaaatcc tgcaaaatgg cggccttgga agcggcggat taaactttga cgcgaaggtc 1858741 agaagatctt ctttcgagcc tgatgatcta atatatgccc atattgcagg gatggatgca 1858801 tttgcaagag gattgaaagt tgcccacaaa ttaatcgaag atcgtgtgtt tgaagatgtg 1858861 attcaacatc gttaccgcag ctttactgaa gggattggtc ttgaaattat agaaggaaga 1858921 gctaatttcc acacacttga gcaatatgcg ctaaatcata aatcaattaa aaacgaatct 1858981 ggaagacagg agaaattaaa agcgatattg aaccaataca ttttagaagt ataacaggat 1859041 aagctccaga tcctgctatc aataccaagt cactgaatta cccgtcatga ttcctttcct 1859101 attgcttgtt gttatgacgg gtaacttcta taattaggat ttatttagag tgaatggttt 1859161 tttaaaaggg caaggagtga aaaaatgaag tatgtcattg gaatagatct tggaacgagt 1859221 gctgttaaaa ccattttagt taaccaaaac ggcaaggttt gtgcagaaac gtccaaaagg 1859281 tatccgctca tccaagagaa ggcgggatat agtgagcaaa atcctgaaga ctgggttcag 1859341 caaacaattg aagcattggc tgaattggtt tctatatcca atgttcaagc caaggatatt 1859401 gacgggataa gctattcggg acaaatgcat ggattagtac tgcttgacca agatcgtcag 1859461 gtgttacgta atgcaattct ttggaatgat accagaacaa cgcctcaatg tataaggatg 1859521 accgagaaat ttggcgatca tcttcttgac atcacaaaaa accgtgtttt agaagggttt 1859581 acattaccta aaatgttatg ggtaaaggaa catgaacctg aactttttaa aaaaactgct 1859641 gtgtttttgc ttccgaaaga ctacgtgcga ttccgtatga ccggtgtcat tcacaccgaa 1859701 tactccgatg cagcaggaac tttactttta catattactc gcaaggagtg gagcaatgat 1859761 atttgcaatc aaattggtat ttctgcagat atttgtcctc cgcttgttga atctcatgat 1859821 tgtgtaggat cgctgcttcc gcacgttgcc gcgaagaccg ggctattaga aaaaacaaaa 1859881 gtgtacgctg ggggagcaga taatgcttgc ggcgctattg gagcaggtat cctttcttcc 1859941 ggaaaaacat tatgcagtat tgggacgtca ggggtcatac tttcctacga agaagaaaaa 1860001 gaaagagact ttaaagggaa agtccacttt tttaatcatg gaaaaaagga ttctttttat 1860061 acgatgggcg tcacgctcgc tgcaggatac agcttggact ggtttaaaag aacgtttgca 1860121 ccaaacgaat cgtttgagca attattgcag ggggtggaag ctattccgat aggagccaat 1860181 ggactgctat acactcctta tttggttggt gaaagaacgc cgcatgctga ttcttctatt 1860241 cggggaagct tgatcggaat ggatggagcc cataatagaa agcatttttt gagggcaata 1860301 atggaaggta tcacattctc tttacatgaa tcaattgagc tattccgcga agcgggaaaa 1860361 tcagttcata ctgttgtttc tattggtggg ggagctaaaa atgatacgtg gctgcaaatg 1860421 caagctgata ttttcaatac gagggtaatt aagttagaaa atgaacaagg gccagctatg 1860481 ggggctgcaa tgctggctgc ctttggaagc ggttggtttg aatcacttga agaatgtgca 1860541 gagcagttca ttcgtgaggc tgctgcattt tatccaaagg cgcaaaatgt tcaaaaatat 1860601 aaaacactat ttgatttgta taagaacatt tacactcaca caaaggatct caatacagct 1860661 ttgaagagct ttcgaaaaaa ctaatgatgt tattgtctgg agatcaaccg aagaacaatt 1860721 aatgatcaat catcatcaaa ggcctttgat aacatggctg ccttcttttg aaaagatggt 1860781 gagaataagg tatcgcaacc tttaaacagt attggagtat ccagcagaca aaacgaacga 1860841 gtggaaccgt attttgtcag cgaacacttc aagaagtggg gaagcttagg aatgccaatg 1860901 ggtaagatgt atgaaaccgc gctaacgacg gtagagggat ctcttgattt atgaagaaat 1860961 aggaaggatg ttaacacaca aataacccct cacattgacg tgaaggggtg ttttttattg 1861021 ttactataca gcggaaattt tacaggctag ttgcatgatt ttagcttgtt aagcagaatg 1861081 gaactagact ctccatcatc tctttctcat tctttggaaa ctgcattctg ctaggtttgc 1861141 tgcttttttt aacaaacagt gtttttctat ttcacacagc cattaaatcc tctgttcgtc 1861201 acataaccgc tcttactcca aattgacagt ttatctgatt ttgcttcttg ctcatctagt 1861261 ctgaattggt ctatgtattt tgtgttaggc tcatatacat atgctactct ggccaatccc 1861321 tctttcaata atgtctcttg aacagatttg ccgtcaacat aaacgtatgc taacagtctt 1861381 ccatacttat ctctgcgatc gcctttatca aattccagct gtagcttacc gctgttgacc 1861441 aattctttat ttcgtttcga cgcatcctca ccgtatggtt gaacacaaga atttggtttc 1861501 ttcgtctcag gtgtatcaac gagcaagtag cgaactgtgt ctttctttcc gttgtaaata 1861561 accttaatcg tatctccatc tattgctcta tctaatgtaa cattgaccaa tttcttctga 1861621 ttttttgaat gaggcgtgcc agccttttgt tctgtctgat tatattcatt agagtgagta 1861681 tcttgagaga cttgctccgt cccattagaa tctgaatggt ttttggctgc gtgatttgat 1861741 ccgcaagctg ccaaagtaat acttaaaacg attgcgatca tactgatcaa aatcttcttc 1861801 atattgattc cctctttatc attttctctt ttcgcgatta aacatcatca ttataacgat 1861861 atggacattt tttgtgaatg gaaaacttca agggaactta taacactcca aattgccaat 1861921 agttaacttc acaacgagat gatcaaaaca tcaccatcac atagcggaaa taaataatcc 1861981 tgaaaataat attgactgaa aatgctttta gaattatgat aatatgagaa atgacaataa 1862041 tgtgacaaag acattactac aacataacaa ctaatagctt aggtttattc tattggttaa 1862101 aaatgtaaac ggttacaaat ccagaggcga aaatctaaga tagagatgac tttagttttg 1862161 actcaatatc cacactgaaa gagcttatta agtattctta aaggcagggg aaatggatat 1862221 gaatgaacat cgaaatcgaa ggttgaaatt aataatgatt tcagcaactt ttggagggct 1862281 tctctttgga tatgacaccg gagttataaa tggagcttta ccttttatgg caaggccaga 1862341 tcagcttgat ttaacacctg ttacagaagg gcttgttacg agtattcttt tattaggtgc 1862401 cgcgtttgga gcgttgttat gcggaagatt ggctgatcga tatggccgcc gtaaaatgat 1862461 ccttaatctt tcctttttat ttttcctggc atcactggga acagcgttag cacctaatgt 1862521 tttcatcatg gcggtctttc gttttttact ggggctggct gttggaggag cctcggcgat 1862581 ggtgccggcc tttttagcag aaatggcacc gcatgaaaag agagggcgta tggtaaccca 1862641 aaatgaacta atgattgttg gcgggcaatt tttagcatat gtttttaatg cgatcctcgg 1862701 tgtaacaatg gcaaatacgg gacatgtttg gagatacatg ctagtcattt gtgctgtacc 1862761 ggctatcatg ttatttgcca gtatgcttaa ggtaccagaa agcccccgat ggctaatctc 1862821 caaaggcaaa aacagtgagg cgctgcgagt tcttaaacaa attcgagaag ataaacgtgc 1862881 agaagctgaa tgtagagaaa ttcaagaagc ggtagaaaaa gatacagcac tagaaaaggc 1862941 atcactcaag gacttttcta caccatggct gcgccgtctt ttatggattg gaatcggtgt 1863001 tgccatcgtg aatcaaatta caggtgtgaa ctcgattatg tattatggca cacaaatcct 1863061 taaagaatct ggttttggta caaaagcggc tttaatcgct aatattggaa atgggctgat 1863121 atcagttatt gcagttatat ttgggatttg gctggtcgga aaagtgagac ggcgtccaat 1863181 attattgatt ggtttggcag ggacgactac agcgctccta ttgattgcga ttttctcaat 1863241 tgtgcttgat ggatctatgg cacttcctta tgtagtgctt tctttgaccg ttttatttct 1863301 tgcctttatg caagggtgtg taggacctgt gacttggctt gtcatagcgg aaatattccc 1863361 tcaaaggtta agaggacttg gttctgggat aagtgttttt ttcctttgga tattaaactt 1863421 tgtgatcggt tttgctttcc cgatcttgct tagctctgta ggtttgtctt ttacattctt 1863481 tatatttgtg gctttaggtg tattggcaat cggttttgtg tacaaattca tgccggaaac 1863541 aaaagggcgt acacttgaag aattagaaga gcattttcgt tctcgacacg atcataatac 1863601 tcctgaacaa tcagttattg aggtataaat atgttgaaaa tctctcttct tataggaggg 1863661 atttttttag tttcagaaaa aacaaaatcc ctctggtaga gggattttga ttcagcattt 1863721 taagatgttc tacacgtata atactggagt tgatacttta aaaatctcgc catctcttat 1863781 ataaaaacga gggatgcggc ggcttaatgt agacacgact tcatagttaa tcgtattgag 1863841 catttcagcc acttcatcaa cggaaatctc ggctcctttt tgcttaccgt aaatcacgac 1863901 ttcatctcct tgtttacctt caccgttttc tcctaaactg accatgatca tatccattgt 1863961 tactcttccc gccactggca ctcgttttcc gcgatgaaga acaaacccgc gattggaaag 1864021 ggcacgagaa tagccgtcag catagccaat cgggagtgta gcaattactt cattaggttc 1864081 tgcgatgtat gtagcaccat agctaacggt tcggggttct gtccgcatgg ttttcacata 1864141 agcgatgcgt gcctttaaac ttaacgcagg ttcaagctta acgagattta gttgtttaat 1864201 ataggctgaa ggatataaac catataagcc gatacctaaa cggatcatat cagcgctaaa 1864261 ttccggaaat gcgatagctg cagccgtgtt gcacatatgc acggtgggca gctcaatccc 1864321 ctgttttttt aaaaagctga gaaaactgat gaatttttca tgctgcagct ttgtgagtgt 1864381 tgtgtccggt tcatcagctg tcgaaaaatg tgtgaaaatc cctgtccatc tgaggaattt 1864441 acttgccttt aaggctttca ctacctctaa aagttcttcc tttgtgcgta cacctaatcg 1864501 tcccatgccg gtatccacgt taatatgaat ggccagccgg ttagcactcg cttctttttc 1864561 caatatctcg tttgcttctt tcatccaatc aacctgaaat gctgataatg ttatattcca 1864621 agctgctgac ttctttacac aactaaggga tgtaaaacca agcacaagga taggtgctgt 1864681 aatcccagct ttacgtaaaa cgattccttc ctccacactg gcaacagcga gctcactcgc 1864741 cccgtgttcc agtgcatggc gtgccacttc tatagacccg tggccataac cgttcgcttt 1864801 tacaacagcc ataattttgc tcttatgtgg aatatgacgg cggatcgctc gcaaattctt 1864861 tttaacggca tcaagattga cttcgatcca aacttctcgg caaagcttta tcatcaacgc 1864921 ttccttcctt cttatggatt ataaatacca cctattgccg caagaataaa tgttaattgt 1864981 tggatgattc gatcttattt tattcaactt tatttgaaat cattcaacag caaatccatg 1865041 tgatacgaga aggtgcctat caatgttcga ataatagcaa gtacgggata catgaggctt 1865101 gtaagtgggg tgttaatgga tgcggcgacc gaggattaca aaaatgatta tttgttttgg 1865161 gacatttttt tctaagggta gatgataacg agaaatctaa tcaggaaata cttaccgttg 1865221 ttatgaacat tgaagaacct tttaaatgag aagggctgag gaaattctgt aaaagataat 1865281 cggttgaaaa ggcagtcgat tccttgttcc ataaacctaa catcagagta tataattata 1865341 ctcgtattca caaaaatcgt ttaagtaagg ggtatacatg aataggggag ttagttttca 1865401 aataccgaat gaatatggaa attttctatg gagaatactg cagccggtag aaatagctaa 1865461 ttataggtgg caaacgagtg gggaatctta ttttgttgta gaaggagagc tcgatgatga 1865521 ggagcttttt catgactacg aaattgttga gggggcagtt tttgagcaac aattaaaaac 1865581 gaatcagtac tataccattt tcgttgaact gaaagcattt ccatatggaa aaatggttaa 1865641 tcaagtcaat acatatgaag agtttgctga cagtgattgc gaacttgtcc ttttgatagc 1865701 agataatagc tacgtttcga tttactgtaa aaacaaaaat atcattgaaa aactttactt 1865761 caatgcttta cagcatgatt ttgaagacgt tcaatttata actgatgaaa atgacacaag 1865821 aacaagcctt actgtatgat actcaataaa aattaaagga gctagtacat gacaatgcaa 1865881 attaaaatca agtatctaga tgaaacacaa acaagaatca gcaaaattga gcagggagac 1865941 tggattgatc ttcgggcagc tgaagatgta acaatcaaaa aagatgaatt taagcttgtc 1866001 ccattaggtg ttgcaatgga gctgcctgaa ggttacgaag cacatgtcgt ccctcgttca 1866061 agtacatata agaactttgg cgttattcaa acaaattcaa tgggtgttat cgatgagtca 1866121 tataagggag acaacgattt ctggttcttt cctgcttatg cattgcgtga tactgaaatt 1866181 aagaagggtg atcgtatctg ccagtttaga atcatgaaga aaatgccggc ggttgaattg 1866241 gttgaagtcg agcatttggg aaacgaggat agaggaggac tcggttcaac aggtacgaag 1866301 taaacaaaat aaatccttgg ctgtcttcat gctgtgtgat tgatcaatgg aggtttcagc 1866361 caaggtacat ataaatatta tgtataaaat gaatatttta atacgaagga tttaattaaa 1866421 aacaaagttt aaaaagggaa gttttgaaaa agtgaaatag taataactaa agtcgataaa 1866481 gaacctaaag atgtcaaaga aacaattttt ctggtgcttt gcttttttga aggtttactt 1866541 agctcgtgga taactgcccc ccataaaagc atggatgcta aaattataat acttatatac 1866601 ataaagatgc tccttttatt atatttacag tttttacatt tttatcgatt ttaccacatt 1866661 taggattgag ttgtcgatga aacaagcatc tctataaaga aatactttta tctaaatttt 1866721 tataaatagg ggaaggcaac taaaaactag taatgccact aataataagc caagttaaat 1866781 gacttgtgtt cattaataat tgaattttac agcagccatg agcacaaaaa aatctgagtt 1866841 cgtcgataaa tatcataaaa aagcccccgg tatgtcgcca gggaataaat agacgtttaa 1866901 gagatttagt gatgtttttt atatgattcg acaaaatcat aataatgatc atcgtcatca 1866961 taatactttt tttcgtaatg ataatcgtga tcatcgtaat actttttatc atggtcatca 1867021 tactttttgt cgtaatcata atgtttttta tcatgatcat aatacttgtc gcaatcataa 1867081 tgcttcttat cattgtcgta atactttttg taatatgttt ttttccaagt ataatactct 1867141 tctttatatt ttttataata acccaattaa attcctcctt tatgttattc gaatttaatt 1867201 tatgaagttt aaatgatatg gtatggtcaa atgaaataag aatagtaaaa agaggctgtt 1867261 taaaacactt tctgaaaaac aaaacggata gctgtttatg aaaataagag cgagagagag 1867321 cactcaatca ctgtaaaata atagtaaagt gtatagagag attagtatac gtaaaaaggg 1867381 actttctcat tgaagaatat ttgaacgtta tggttaagat tcaagagctc tatgatgtga 1867441 tttttcacac tgcttttgaa ggatttagag ttagacatca aaaacaaaca gcaaaaccgg 1867501 ctagaaacag atcatataag gaatgaaccg ctgccaaata tcataaaaaa gttgttaatg 1867561 atcaaatgaa tgaaattaga gagaatttat tttaaagaaa gcccaattgc acatggacaa 1867621 atgacaattg atattgaggt aaaatacaat gcattaaatc agaaaaagct attggaggat 1867681 ttaatgtgtt tagacaattt ccaatttggt atacacaaac acctgactat ttgaattttt 1867741 atgtaccgca atatcaaacc atttcgtata atcctcaaca atgttatcaa cggtgtatgt 1867801 accaaactgg cggtaactat gagctatgtg acagactatg ttatggagaa atacaggtgt 1867861 aaaagagggg gattaactcc tctttaaaca cacagtgagt ggaataagat cctcacttta 1867921 tctgcaagtg cttagtattt gcgataatat tgcattcgta ataaattatg cttagcaact 1867981 gaaaatgaaa gaaggatatg aatagtcatg acgcaattcg ataaacaata caattcaatt 1868041 ataaaggata ttatcaataa tggaatctca gacgaagagt ttgatgtaag aaccaagtgg 1868101 gactcagatg gaacaccggc acatactcta agtgtaatca gtaagcaaat gagattcgac 1868161 aactcagagg ttccgatttt aacgacaaaa aaggttgcct ggaaaacagc cattaaagag 1868221 ttgctctgga tttggcagct gaaatctaat gatgttaatg atttaaacat gatgggcgtc 1868281 catatttggg atcagtggaa acaagaagac ggaaccatcg gacatgcata tggatttcag 1868341 ctggggaaga aaaacagaag tctaaatgga gaaaaagtgg atcaggtaga ctatcttctt 1868401 catcaattga agaacaatcc atcttcacgc agacacatta caatgctgtg gaatcctgat 1868461 gaattagacg caatggcctt aacgccatgt gtatacgaga cacaatggta cgttaaacat 1868521 gggaaactcc accttgaggt aagagcacgg agcaatgata tggcattggg aaatccattc 1868581 aatgtattcc agtataatgt gttgcagcgc atgattgctc aagtgactgg ttatgagctt 1868641 ggtgaatata tctttaacat tggggattgc catgtgtaca cacgtcatat agacaatttg 1868701 aaaattcaaa tggaaagaga acagtttgaa gcacctgaac tatggatcaa tcctgaagtg 1868761 aaagattttt atgactttac cattgatgat ttcaagttaa tcaactataa acatggggac 1868821 aagcttttat ttgaggtagc ggtttaatgc tgccttttta ttgtgcagtg aatagatagc 1868881 aggtatccta atttcattaa gcaatctgga agatgaataa aaattgaagg acaaacacgt 1868941 ataatacata aaaaagatta actctacagt taatcttttt tattcagaag aaaatatcct 1869001 aactttgaaa ctaaatacaa agtaaaagca atcattacag ttctagatat tacaattcca 1869061 tgaatagcta gatcatatcc agcaggtatc aacgcatttg tattacacat aaaatatata 1869121 gatattagaa gtgctacaat aactaaaatc attccaaaaa gacttgtttt ttcatatttc 1869181 ataccaattt ccacccttat taaagttagg tttaaacaaa agagctgaag aaacgaacta 1869241 tgaccagtat gctccaagga aaaccgccag acaatgctgg cggctttttg ctgcttcgtt 1869301 tatttattaa cagagatcgt aacgttattt cctgcaactg aaacctttgc gaaatcctgt 1869361 gtatctacca caggagtgac ggctttattg tcgatagtga tgttgttaaa agaggtcgaa 1869421 aaggttgctt tgatcgcatc acgctggctt tcatacgaaa cagccgcggt agcaagtgtt 1869481 ttccattttg aaatcgtgcc gatgttggtt ccttgaattt ctgtgataat ccgtccggtg 1869541 tagccgtcat tgttcgttcc ccaaagggtc atgcgcgtat tgccgcttaa atttttatag 1869601 attgtcattt ggactgtgct tccagggcgg aagcctttat tgtatgtgaa tttgtctttt 1869661 ccttcgatgt acgtttcttc atttttggac ccaaccttca tgaggggctt ccagacgttg 1869721 tattgtttgc tgtactgaag cccgatatcg gcttcagttc cgcttgttgc cctaaagcca 1869781 gaataaatat agggagtaga gaccgagtcg ttgtttttga cagtttcagg aagcacgatt 1869841 ttagctgtaa aaacggcgcc cgtactgttc aggtagacac ggccgccgat tccgttaggc 1869901 agctcggatg ctgcttttgc gacttgagcg tctgccgcgg gtaaacctgg tatacctgat 1869961 gaaagggttc cgaaaagaac tgctgttcct actgcacctg caatcaatac ttttttcacc 1870021 aaaattcccc cttttgatag tggtttcgcc atttattata ccttattttg gaactggatt 1870081 tacgtatata aatcgacaaa atatttcatt ttgaatgatg taaggtcgaa acgcttcgcc 1870141 aatctgaaag ctatatacct ttatcagagg aaagaatgag atcacattcg ttttaaccga 1870201 tttgaaattt tcctcaaaat aaaagtacaa atgcttaaag aaacgattat taaaagaatg 1870261 cccgctatcg tttccaagcc tgtaaaaaag aggtgacgtt tcatcaatgt ctgtccttgt 1870321 aaaatgataa aagcacagat accgactaag aaaagaaaac aaatacttag gattgctaac 1870381 gctttacgtg agtatgtttt catttcatct ttaaaataca gcaatacgaa aataaagcag 1870441 ataacattgg ctattgttct aatcacctca aagcttttca tgacaactga tataaataga 1870501 caaagtaaaa tgagataaaa tacgatgttt ctatacaaaa aacctctcct tttatgtagg 1870561 atcctcaaag agtttataaa agtttctttg taactgcaat aaattgaatg cgctcactta 1870621 tgaactaact aaactatgta ctaaatattc actattcttt ttcagattca gtcaccaagg 1870681 ttttcataga aagggaagct tcagaaatat acatatagtg cacaaacaaa aaagacccgg 1870741 caatagccgg gggaaagtaa aaacgaggag atgttaatgg cgtttagtag tgttttttat 1870801 gctttttata ctctacaaca taatcatagt cttttttatc gtgatcataa tattttttat 1870861 catagtcatc atattttttg tcgtaatcac agtcataatc ttttttatca tattcgtaat 1870921 acttcttata atacgttttt ttgaccgtat aatactcttc tttgtatttt ttgtaataac 1870981 ccatatatac tcctccttta tttttactac gctttattat acggcgagta gattttgcgg 1871041 cttggacagt taaaatcata gaaggaaaaa agggctgtcc aaatgataga aaaagacaga 1871101 tgacacaaaa acaaatcaaa ataaagagcc gatttttcat cggcccaaac gatttatcct 1871161 acatttgttt gtcttctttg ttttctgagt cattttttct gatatcctga gtcagtccgc 1871221 ttgttgcttg tttaaattct gataaggctt ttcctgctgc acggccaagc gccggcagtt 1871281 tatcaggccc aaatactaaa aaacccacaa acaaaataac gagtattttt gtgaagctta 1871341 attccatatc cttttccccc tgattgaagt acaacctttt aaacaaatta taagagatag 1871401 cagtacaaat gggaatgcat ttattttgaa cattttaaaa ccagcacaaa gacggattca 1871461 taaaacggct gctgctgaat ataatgtcca atgccacctg cctaagaagc aggaggcagg 1871521 ctggatcaat tatgtagctc tgccggaaat gatacaaacg tagcggctat cattgacata 1871581 gaggagtggt gtagctgatg agattcacta aggtagttgg atttttgtct gttttagggt 1871641 tggctgcggt ttttccatta acggcacaag cagaaaaagc cggaactgcg ggggctggag 1871701 agtgggataa gttggggact tacacatata cttactcaag tccgacggta tactcgaccg 1871761 gaggagattt tagagtgtgc ctttcaggaa gcactccttt ttctgtttca ctgcacttat 1871821 atgaggatga tcccggtgac aatcctgatg attatgtagg ggcaaactat ttttcacccg 1871881 gagaatgcca cacctttggc agtattggaa aatttgtaga tgggagcaat aacaaggccg 1871941 agttctttgt taccgattac tctggtaaat ctaaaactgt tacgttttat gattgatgga 1872001 ctcaaattgt gaagtataac ccttggaaaa aaacaaaaaa gagagatacc tctctctttt 1872061 ttattcttcg acagccttac gaagccgttc atttacaatg ccagtccagc cgccatccat 1872121 cttaccgcga acgacggagc ttttctcgtt tgctttgccg atcacttcat tcggctcttt 1872181 ccagccgctg tgaataaggg taaaccctgt cttttccccc aagtcttcta attgaaaggt 1872241 aacgacccat ccttctgtat cccattcaaa agaaagttca gttggagctt gaacagccaa 1872301 aactttacaa ggggacggcc caaacggcga ttgtaagtga aattcttgtc cttctttgag 1872361 ctgaaagtca ttgggcataa accacttggc aatgccttct gaagtagaga ctgtctccca 1872421 gactttctga atgggagcct ccagagtaat gctttttgta atatccggta atgcattttc 1872481 gttgttttga gccatttcgt ttacctcttg acatatgatg ttttttcaat tcaatcatat 1872541 aataactaat aagatcatgt ccatagcgtg cattatttat gctagagctg ctgttgaaca 1872601 gcgtgtcagt cgccagtctg atctgtgaat gggagaattc tgcatgcgcg aaaaagagag 1872661 agaggtgtat gttgtcattt cgttcattct tgtttgcagc cgcaactgtt atgtttgaac 1872721 tgggattcct gttcagccaa tttattttgc gatttttgtt ttaatagtaa atgagccatt 1872781 ttctaaaaca ggaggttttt tatgcttgga aaaatcaaag cagccattga taatagtcca 1872841 gggaagccgg ccagaatttt agttagtgaa aaagcgtttc agcaattaga ggaagaaatg 1872901 cgctttgttt acgtttccaa accgaaaacg ataatgggga ttcctgtgga agtttcagat 1872961 caggcagaaa gcttcaagct ggaattttag ttttcccaga ctgctaaaag gctcattttg 1873021 tgttaattat gcaaaatggt caggttgatt tctttaaaag catgatgaaa tgttcatcat 1873081 gcttttttat tgagaaaaaa gacgaacata aaaaataggt atacgggaaa aataatccta 1873141 ttagagagag gggaactgac agatggataa catgatatca acacttactg actggaatgt 1873201 gtggtttcaa gcgttagtag tatttctcgt tccatatgta atctataaag tgtttacttg 1873261 gattcatgta taagaaggtg caatgatgag gtggcggaac aatcagtaca aaacacagaa 1873321 gcagcataaa tcagattatt cgacagctga aaagcaggat caggatgtgt taaccggtaa 1873381 catcggatac gacttagaac atgtaaaaag aaaaatagga cataacgggg acgttcattt 1873441 ccgtgagctt gaaatcactc aattacatgt gaaagcggca ttgatctttg ttgaaggact 1873501 gtctgatcag gacttgatta ataaaggact atcagtgtta gtcatgaatc aacctaatca 1873561 ggtaagcgat gaaatttctc aatccggcaa aggtatttta acttcgaaac agataaaaaa 1873621 tcaaatcgta tcaatcggtg atgtcataga ttcagagaaa atcagtgata tcgtgttgaa 1873681 tgttttcatg ggttcgacag cgcttctcat cgatggaata ccgcaggcct ttcttctggg 1873741 aactgtaaaa aaacaaaatc gaagtatcga ggagccgctt tcagaagcgc ttgtcagagg 1873801 gccgcgcaca ggctttacag aagagttgag tacgaataca gctcttttga gacagcaagg 1873861 aaaaaatgat caattaacat tgcagagatt tgaagtagga acacgattaa aaaaggattt 1873921 aattatcgct tatatgaatg acattgcaga tccaaaagta gtcgaggaag taagaaaaag 1873981 agtgagaggg attgagatcg atcatttgcc ggagtcaggc tacgttgaac agttaattga 1874041 ggataattat ttgagcccgt tcccgcaagt acagagtaca gaacgtcctg atcgcgtcat 1874101 aagcggatta atggaaggaa gagtagctat tctgcttgac ggcactccgt ttgctttgat 1874161 tgttccagtc actttcagca tgatgcttca atcgcctgaa gattattatg aacggtggtt 1874221 cccgagctcg ctcatcagat tgctgaggtt catcgcagca atgataacgt tattcgcacc 1874281 cgctttatat atatcattta tttcttttca tcctgggtta attccgacca agctggcgat 1874341 ttcaatttcc gggacgcgcc aaggtgttcc gttcccatct ctgattgaag ccttatttat 1874401 ggaagtcgcg attgaaattt taagagaggc ggggcttcgt ttgccaaaac caattggacc 1874461 cgcaataggc atagttggcg gattaatcat cggggaagca gctgtgcagg cggggattgt 1874521 cagtccaatc atggtcattg ttgttgcgct cacagcaatt tcttcatttg ccatcccgca 1874581 ttatagcaca ggtatagcac ttcggatgct tcggtttggc gcgatgtttt gtgcggcggt 1874641 gtttggattg tttggagtca ttatgtatta tctgctgcta agcagccatg tcgtaaagct 1874701 aaagagcttt ggtgtgccat acgcaagtcc ggcagtgccc tatcacttaa aagattggaa 1874761 agactttgtt atcagaatgc ctcttttagt catgaagcgc cggcctaaaa tgatgaatac 1874821 agataataca aaacgggtga agtgatgaac tcgacaggat ggtgataaag tctcatgttc 1874881 agcccaacca gtaaaatcac aaccgctcag gcaacgatta tcatcattaa ttatatgctt 1874941 gctgccggag ttcttacgct ccctcggaca gtaacagaac aaacacaatc tcctgatgga 1875001 tggatttcag ttttattagg cggggtccta gcggtaatag ccgggatgat tatagctaaa 1875061 ttaagccagc agtatcctaa ggagaccttt tatgaatact cccgacatat tgtaggaaaa 1875121 tggctcgggc atctgatcag tattgttttt attacttatt ttctggcact cggtgcattt 1875181 gaagtcagag tcatgtccga aatcgtggat ttttttctcc tcgaagggac accttcttgg 1875241 gccatcatta tgacagttct ttggattggg ctttattcaa ttacacaagg cctagatccg 1875301 attgcacggc tttttgaaat gatttttccg attacggtca tcatcttttt aacgatagcc 1875361 ctcatgagtt taggcatatt tgagatcaac aatttgcgcc ctgtattagg tgatggaatc 1875421 atgccggttc ttagaggtgt aaagacaacg aacctttcat ttacatgttc agaaattatg 1875481 ttcattttag tagcatttat gaaaaagccg aaaaatgcgg tgaaagcagt tgtgatcggg 1875541 acaggcgttg tgaccagttt ttatatgatt acgatgatta tggtcatcgg tgcactatca 1875601 gttgagggag ttgtgacgag aacatggccg gggcttgacc tgatgagaag ttttgaaata 1875661 cctggtttaa tatttgaacg gtttgaatca tttctgcttg tgatttggat tatgcagctt 1875721 tttgccacgt ttattatcac tttttatgca gcttccctgg gagtctcaca agtttttaaa 1875781 aagaaacccc tttcatgtat gtttgggctg cttcctgtta tatatatcct ctcttgcatg 1875841 ccgaaaaatg aaaatgacgt ctttatattg ggcgatacgg tcagtcatat cgctttgtat 1875901 atatttggcg ctttgccgat tttgctgtta gtcatttcga aatggaggaa aagaggtgaa 1875961 aagtaaacta aaacgtcaat tgcctgctat ggtcatagta tgtctgctga tgatttgcgt 1876021 aacaggatgc tggagcagtc gggaaataga agatctgggt ctcacattcg ctatcgcaat 1876081 tgataaagga aaagaaacga acactgaaaa agagttaaaa gaagagggcg ggagctatcc 1876141 gaaaaaagac aacattacgc tgacctatca atttgttaat gaaaaagcgg caggcgcggg 1876201 cacaagcggg ggaggcggta gcggacaagg agcgcaaaaa gcgtacatta atataagtga 1876261 aacaggggat tcattacagc agatcggaag tgaggttgca ttaagacggg accgagaagt 1876321 gtttagcccg catttaaaag ttgttgtcat gagtgaagat gtgctgcaca catttcctat 1876381 cgacgaaatg ctggatcaat tttttcgtga taatgaaatc aggctgagct gtcttgtttt 1876441 atctgctaaa ggggaagcaa gagacgctct ccagctgaaa gagaacggag aaattccggc 1876501 atttcggctg attggattag gtgaaaatga acataaagtt tccagaattc ttccccctat 1876561 gacactcgcg aaactaattg gaaaactgca ttctggcagc agctttttac tgcaaaatgt 1876621 ggttgcggcg aatggagcgg tcaagtattc cggagcagct gtaatcaacg gaaaatcgaa 1876681 aaaaatgata ggcaccttaa atgaatatga aactgagggg attacatgga ttagaggaga 1876741 agggaaaggc ggagttgtca aaagtcatga taaaaagagc caacagacgt tagcgtacga 1876801 tatcaataaa atcaaaagca gaattcagcc aatcgtaaaa gggaaagata tttcattcca 1876861 tgtcgatatt gaatcagaag gcgatttggt tgaaaactgg aacacaaaag aggcgttgga 1876921 cacccagttt atagatcgtc tcgaaacgac tattgaaaac gaggtaaaga aaatagttgg 1876981 tcaggtatta aaaaaaattc agcatgatta taaagcagat gttgcgggtt ttgatgaatc 1877041 ttttagactt acatatcctc acttatggaa aagggtgaaa aataactggg atgacacctt 1877101 cagtaaagcc gacatcacat acagtgtgaa cgtcacaatt actcatttcg gcacggttaa 1877161 aactcagtaa tgaatcccaa ggaagagaag gaaacctctc ttctcttttt tatgcattta 1877221 ttaggataaa gatacttttt ttggagagat atacactttt caaatcgacc aatatgctaa 1877281 tataggaatt gcttgaaata gaagggagaa ggggctgtga ggcagaaacc gatttatgta 1877341 gaaatcgaaa tgaaatctga tctggataca ctctgggaat atacacaaaa cccatcactg 1877401 cataaggaat gggatctccg gttttcaaat attacgtatt tgaatagtca gccatgcgaa 1877461 aaacagaagt ttctttacga aacaagggta ggctttggat taaaggtgtc aggtacagga 1877521 gaaaccgtcg gtgttttcaa caaatgttca tctgaaaggt cttcttcact ggcttttggc 1877581 tctgatcatc cattatctct gattcggcat ggaagcggct actggaagta tatacagaga 1877641 gaaaatggga aaatgacgtt tttaacacag taccaataca aaacagccta cggactgctg 1877701 ggaagatgga ttgatcgttt attatttcgg ccgctgcttg gctgggcgac tgcctggagc 1877761 tttgatgcat taaggctttg ggtagagcaa aataaacatc cgaagcgctt cattcgatct 1877821 gctatcatct atgtgttcat gtgtctgttt ttcagcctgt tttggttcta tcaaggcttt 1877881 gcaggtgtta agacaagcat attgacagga acagcggaga taggcttagc tattttgtgg 1877941 ctgcttcctt taaaaagaaa atggatcatt catggtgtcc aggcttgtat ttttgctggg 1878001 tttgcttgtc taggttccga aatattcatg tgggttctat tgagtgtgtt ttccgctgca 1878061 agcggcgctc ttagcctgca gctccccagt gccaggcgca caaaacgaaa gagaaagaag 1878121 tgacattgtg agttcgattt atgaaaaatc aattattaac tatcatttgc tgcatcccaa 1878181 gctgcagaaa cggtaccaat tagacgggtc tcatacattc agcgggacgg gaacgatgtc 1878241 agaaataagc ggaggctctt ttctggttag aatgctgtta aagctgggtg tttttttcag 1878301 atgcttcttt tcagaaagag gcaaagacat tccatttaca atacaaaata gaacttgtct 1878361 tttgaaatcg caacatacag gaatagaatg gaatcgtaca tttttcttta aaggcaaaaa 1878421 acgtttcttt gatgcgttaa tgatatatga cgagaaagaa aatagaatac ttgatttctt 1878481 cggcaaacct catctgctgc tgtctgtttt gacgttcgag gcatctcttg acggctctct 1878541 tacgatcaca tcgggaaagc aatggctatt gatatgcgga aaaagaatcc cgctgccgaa 1878601 atggctgacc ggtacatccg aagtttgcga aacgtttgat gaaaaaaaga attgtttcac 1878661 cattgaagtg catgtgcaaa atacaattct tggcactctt ttcttttata agggaacgtt 1878721 tcaggaggaa gagagagaat catgaaacga aatggcatag tcagtgcgct ttgttttatt 1878781 ggatttcttg cagcagaagc accggatatt tcagtggcag aggcactcgt tttgttatcc 1878841 attctatttt tcgtgccggg aatttttcct tttgtttttc gtcaatctcc ggttcgtgct 1878901 gctcagttta tggaaaacgg gctaatccag tgctatcctg tagccgcatt ctttgcggtg 1878961 ctggctctag tgacggaggt tgggggtttc gcacttatct ggtggatgta cacagttttt 1879021 aatgcattgt atgcgatcct ccgcctttgg gaaacaaaga tacatagaat cgaagagaca 1879081 tcagttttgt tcggtcttat ttatttggcg ggaggaggat tttggttttt tgcttatgct 1879141 gcccatttgc agatcatgca atttggccct ctcatcattt tgctgactgc tgtccacttt 1879201 cactattctg cttttctgat cccgatcttc aacggtttac tcggcagaac cattagaaaa 1879261 catcggatgt tgtacagttg gataacatgg gtgattttgc tttcgcccct tcttatcgca 1879321 ctgggcatca catattcaaa aacacttgat gtcattgcgg ttagcattta tatggcggcg 1879381 atttatcttc atgcattttt ggtgttcacg gcagcttttc gcaccaagac ggggacattt 1879441 cttattcggc tttcttccgc tgttttaatg ataacgattg ctttctcgat gatttattca 1879501 tttggtgtct ttcggcaaga agttacattg accatcaatc agatgatttg gattcacggt 1879561 tttgtcaacg cgtttggtgt tatcttgccc gctctcatag ggtggagaat agaggatgcg 1879621 aaaccttttg atgcagacag tgtaaagaca ttcagccgta tctacggaaa aagaaagatt 1879681 ggagaagaat ttttagctaa cattcaagct gaaaataacg ctcggtacag cggacttgtg 1879741 gatgatatgg gcagcctgcg ttcaaaagat ttttcaccag aaaaactggc gccgctcatt 1879801 ctttcgtttt atgaacaaac catcgaatac aatattaaag caaaagtaac atggagcacg 1879861 tggtttcggc cgcttgcaat tatttacgaa tggttcagca gaagaatcgg ccaaatacat 1879921 ctttcgacga accctgactg gtataggatg tacagcaaga taaaaggtgt tcattcgaaa 1879981 aaagacggaa gggaaagagt acgtgcctgg attagaacaa atgaaaaaaa cgaaaccatt 1880041 tttaccgctc tttattcagt gtatcgttca aatggagagg ggtatatgaa tatttcttta 1880101 ccgcttccat tcagcagcat gacaggtatt ttaaaaccat atcatcatca ggagaagctg 1880161 gttttaacaa gcaggcggag aaaaagcaga gcgggggatg aggggattta tctgcaaaca 1880221 agagcgggaa cttgtccgct tcctttatct gaaacctttc tgatagaagc tgtacatgac 1880281 aacaaattaa ccgctgttca tcatatgtgg ctgtttggaa taaaatttct aactgttcat 1880341 tacagcatta cacatattaa ccagcctatt gaaagaacct aacacaaaga agaagcttcg 1880401 tctgccagtt gtaatgagat gaactgtttt aaaattctgc accgcatcaa gacaggaaag 1880461 gaagggttta tggtgtttta tatcagttta tttctgattc tttggctggc tgctgggttt 1880521 gcagtgggaa tgaaacaagt gtatgtcgat cagctgtttg ataaagctgt gatcgaaaga 1880581 ctggaaaaag aagcgaatga tcatggacat gctgaccgga tgatcaaaca gcgcgtcctt 1880641 tatattgcag cagtgacagt aagcgggttt atttctgttt attatgaaat gaaaacaatc 1880701 ccgcaaaggc gaaacataag aaaaattgaa aaaaacatca tgaaattaaa tcaagcaaaa 1880761 aaacgaagaa tgaagagaaa ataaaaagtg cacaggccaa agggcaggtg catttttgtt 1880821 ttgtatggaa aatgggggag gtggtgccag cttacttttc ataaattcaa aaatgagaag 1880881 aacagcgccc gggctaatgg tatataatat tgtgaattta acaaaaattt aacaaggagg 1880941 acgagagaat tcgtgctaaa gcctcaaaga gacctacatt ctgttgattt ggacttagag 1881001 gcggagtaga tgaaaccggc caaagtatcc ctgctccgcc gtttgctcca ttccttgaag 1881061 catgttgatt gtaacatagc caaacgtttt ccatcaacta ttaaaattgt aaaattattg 1881121 atgattttta tggtgtttac tccgatttct tcaatttatg ctgaagatgt atatcagaat 1881181 tttgaggaat taaaaaacaa tgaagatcct tctgattatg gcgttgttac gaaagaaacc 1881241 ggaagccctg ttcttgtttt agctattcac ggaggaggta ttgaaggcgg gacaagtgaa 1881301 gtagcgagag agctcagcaa agagtactcg atgtatttat ttgaaggctt aaaatcggca 1881361 ggaaactcag tcctgcacat tacgagcaca cactttgatg aacctcgggc ccttaaaatg 1881421 acgggaaatc atgaatatgt catttcatta cacgggtacg cagaagaaga tcagcagatc 1881481 gaagtcggcg gtacagatcg cgtaagagcg gcagatttag ttgagaaatt gcagcatgcc 1881541 ggttttcctg ctgtattgct caatatggac catccgcatg cgggcgttag tccgaataac 1881601 attgcaaata aatcaaaaac aggtttaagt attcagatag aaatgagcac agggtttcga 1881661 aagtctttgt tcggcatctt ttctttaaaa agcagagctg ttactcaaaa tgagaggttt 1881721 tatgagttta cagaagtgat gttccgtttt ctcaaaaata gctactgaaa aataggaggc 1881781 gataagacag cctcctattc cttatgcttc tctttcgttt cgggaaacag ctcgtccgcg 1881841 gcttccgttt gatactgcaa cgtgttatct ctcgctgaca gttcatttcg gaaattttca 1881901 tcaagcacat ttttcagtaa ataccgatga aaaaagtatt caaaaacagt aagacaggca 1881961 gcggaaagga gagccgctcc aaatggtgag aaatcgtttc ttgtttgggt taaaacaaat 1882021 acccaaagaa taacgaatga aaggccaaag tcagccaatg aagctgtaat attgtttgtt 1882081 ctgggtaaga cgagcatgtc accagaaaga taggaaacaa aacctaagaa aagtgcaata 1882141 aacatcacac ttaaaaagga tgcgtgatag actctgtcca aaatcacata taaaagggcg 1882201 agagtgaaag caatctttga agcaagcgca atgatatgtt tcatttgacc acctaaattg 1882261 ttattttttg aagaaaattc ttgggcgtaa acaaatgata aataatgcaa ttcaaaacca 1882321 ttcataatgg tcatgttact attttaaaca gtccgttttt gtttacactg gtattttttt 1882381 cagctgtatg aaactttctt atgaaaaaag tcgtatatgt ggatgatcag ctttcaaggg 1882441 gggaatgatt tgtggagata aaaggaatca atcacttgct attttcagtt tcgcatttgg 1882501 atacatcgat tgatttttat caaaaagtgt ttggtgcaaa gcttttggta aagggaagaa 1882561 caactgcata ttttgatatg aacggcatct ggctagcgct taatgaagaa ccagacatcc 1882621 cgagaaatga cattaagctt tcttataccc atattgcttt tacaattgaa gatcatgaat 1882681 ttgaggagat gtcagctaaa ttaaaaagac ttcatgtcaa tattctgcct ggcagagaac 1882741 gagatgaacg cgatcgaaaa tcaatttatt ttaccgaccc tgacggccac aaatttgaat 1882801 ttcataccgg aacccttcaa gacaggcttc gatattacaa acaagaaaaa acgcatatgc 1882861 acttttatga tgaaacggcc ttttgatagc acaaccatat ttcatataag gttaaattta 1882921 aagaagggtg ttggtggaga ctttatgttt ggggaaggtt tctacccgac ttgttcaacg 1882981 atgccatatc ttttgaactg cacaagtgat tgggtgaagg tgaaattgaa atacacatta 1883041 cattacattt tatatgaaga aagcgagctg ttttatcaaa tgttgaacta attaaactat 1883101 gtactaaatt ttcagtatat ttcaattgct ttgcccctta ataaatataa aaccgcatcc 1883161 ttccacgacc taaaaaatga aacgttttta agaagatggc gtctaatatt ctaaatgttc 1883221 atattttgat aaaagtttcc taaaggaaag aaaatttctt gacttcaaca atcttttggt 1883281 ggataattat ggtgtaaaca tgatgttctt tttcctccta ttcgggctcg cacccaaaag 1883341 tcagggcgag cctgcttttt ttgaacaaca aaccccctct ccgtaaagga agagggggtt 1883401 attttatgca tctgatagat caatagatta atggacggtt ctgaacacgc caatcacttt 1883461 ccctagaatg ctgacattct gcaaaatgat aggttccatc gttgggttct caggctgcaa 1883521 gcgaatgtgg gtatcctctt tatagaatcg ttttacagtt gcttcatcat cttctgtcat 1883581 cgcaactaca atttccccat tgttcgctgt gttttgctgt ttaacgatga catagtcctt 1883641 atcgagaata ccagcatcta tcatactgtc tcccataatc tccagcataa atacatgctc 1883701 gtctggagga accatgcggt cagggagcgg aaaatattct tcaatatttt ctactgctgt 1883761 aataggagat cccgccgtga ctttcccgat gaccggtaca ttaacgacct ggctttgcgg 1883821 aatgtctact tcttcatcaa gaatttctat tgctcttggt tttgtcggat ctcgtctgat 1883881 cagccctttt gtttccaaac gggccaaatg gccgtggaca gtagaactgg acgcaagccc 1883941 gacagcctct ccgatctctc tcacggaagg cggatatcct tttgatttaa cctctgcttt 1884001 aataaaacgg aggatatcaa gttgcctttt tgatagcttc gtcatttttc gcacctcaaa 1884061 acgtcgattt taagaagatt atagcatgat tttccttaca gtacaaacat aggttcgaaa 1884121 aaacaattga cagaaacgtt tgttcgtata tactgaaatt ataaaaatgc gaacaaacat 1884181 tcctgttgga ggttatgatc atgagtaaag aatctattat ttttgtcggt ctgtttacag 1884241 tgattttgag cgcggttatc cttatgctgt catatacaag cagcggccaa gagcttaatc 1884301 agtatgttaa aatagaagtc cagcaaggcg acacactctg gtcaattgct gatcaggtag 1884361 ccgatacaaa aaagataaac aaaaatgatt ttattgaatg ggtagctgat aaaaatcaac 1884421 ttcaaacctc tgatatccag ccgggtgatg agttagtgat cccattgaaa aagaagcatc 1884481 aggatgcata tgaattagca actgtaagat agagaggaaa gagagataaa atgaaagcac 1884541 tcatttatgc ccgtgtaagc acaaataaag aacagcagga aacgtcatta aagcggcagg 1884601 aggaggagct tacggccatt gcagcggaga acggcatgga agtggtcaaa gtgatttcag 1884661 aaaaagccag cggatatgaa atggatcggg atggtgtatt tgagctgctc gatgagatta 1884721 agaacgctga tattgatgtc attttggttc aggatgagac aaggctcgga cggggaaacg 1884781 caaaaatcgc actgcttcat tgtatttata gagaaggtgt gaaagtctat acaacggctc 1884841 atagaggtga actggagtta tcggaggctg actcaatggt cttggaaatc gtcagcattg 1884901 tggaagagta tcagcgaaag attcacaaca tgaaaatcag acggggaatg aaacgtgcag 1884961 taaaaaacgg ttttaaaccg caaaaaaact taaaaaacca acatgggaac agtggaaaag 1885021 aaaaaataga ggtgccaatc tcagagatcg tccgcctgag agcgaataaa ctgacgtttg 1885081 ctgaaatcgc ggctacccta agagggtttg gctatgatgt ctctaaagca accgttcacc 1885141 ggcgttttca ggaatacata gagaatgaag agactgcaga gtgaatcagt tgtaaaactt 1885201 tttttgatct agtactatat agacaaaatg caataaagga gtttaacatg atttcaaacg 1885261 cgaaaattgc cagaattaat gaacttgctg ccaaagctaa agctggcgtt attacagaag 1885321 aagaaaaagc cgaacagcaa aagctccgtc aagagtactt gaaaggtttt cgttcttcta 1885381 tgaagaacac gttaaaaagt gtgaaaatca ttgacccaga aggcaatgat gttacaccag 1885441 aaaagctaaa aagagaacaa agaaataaca aacttcacta atataagagg aatacggcaa 1885501 tatcgtattc ctcttttgca tatactataa tcaaaactct tatgtgacaa aattcaacaa 1885561 gtttctctca aatttaagct gaaacagttg agaaaaagtc gtcagacatt tatgatgtaa 1885621 gggtacaaca cataaggaag gggattttta tggatacaat tgaaaagaaa tcagttgcta 1885681 ccattcgcac actgtcaata gacgctattg aaaaagcaaa ttctggtcac ccagggatgc 1885741 cgatgggagc cgctccaatg gcatacacgc tgtggacaaa atttatgaac gtaagtccgg 1885801 caaaccctgg ctggtttaac cgtgaccgtt ttgttttatc tgctggacac gggtcagcac 1885861 tattatacag catgcttcat ttaagcgggt ttgatcttag tattgaagat cttaagggat 1885921 tccgccagtg gggcagcaaa acaccaggac atccggaatt cggacatact gccggtgttg 1885981 atgctacaac aggtccgctt ggccaaggaa ttgccatggc agtcggtatg gcaattgctg 1886041 aacgccattt agcggaaaca tacaaccgcg attcatttaa cgtagtcgat cattatacat 1886101 acagtatttg cggtgatggt gatttaatgg aaggtatttc ttctgaagcc gcttcactcg 1886161 caggccatct tcagcttggc cgtctgatcg tactatacga ttctaatgac atctctcttg 1886221 atggagacct cgaccgttca ttctctgaaa acgtgaaaca gcgttttgaa gcaatgaatt 1886281 gggaagttct ttatgttgag gatggaaaca atattgaaga attaacagcg gctatcgaaa 1886341 aagcacgcca aaatgaaaag aaacctacat taattgaagt gaaaacgaca atcggattcg 1886401 gttcacctaa ccgtgccggt acatccggtg ttcacggtgc gccgcttggt aaagaagaaa 1886461 gcaaattaac aaaagaagct tacgcgtgga catatgaaga agacttctac gttccgtcag 1886521 aagtttatga gcatttcgct gtagctgtta aagaatcagg tgagaaaaaa gaacaagaat 1886581 ggaatgctca attcgctaaa tataaagaag tttatcctga acttgctgaa cagcttgaac 1886641 tggcaatcaa aggagagctt ccgaaggact gggatcaaga ggttcctgtg tatgaaaaag 1886701 gaagcagttt ggcatcccgt gcatcttccg gtgaagttct caacggactt gcgaaaaaaa 1886761 ttcctttctt tgtcggaggt tctgctgacc tagcgggatc gaacaaaacg actattaaaa 1886821 atgccggtga ttttacagcg gttgattact caggcaaaaa cttctggttt ggtgtacgtg 1886881 aatttgcgat gggtgcggcc ttaaacggta tggcgcttca tggcggtctt cgtgtattcg 1886941 gcggaacttt ctttgtcttc tctgattacc tgcgtcctgc gattcgcctt gcagcgttaa 1887001 tgggccttcc tgtgacatat gtcttcacac atgacagtat tgcggttggt gaagacggtc 1887061 cgacgcacga gcctgttgaa cagcttgctt cactccgtgc gatgcctaac ctttctttga 1887121 tccgtccagc agacggcaat gagacagcag cagcatggaa gcttgcagtg caaagcactg 1887181 accacccaac agcgctagtg cttacacgtc aaaaccttcc taccatcgat caaacatctg 1887241 aagaagcatt ggcaggagta gaaaaaggtg catatgtcgt ttctaaatct aaaaacgaaa 1887301 cacctgacgc tcttctcatc gcttccggat cagaggtagg tcttgcaatt gaagcgcagg 1887361 ctgaattggc aaaagaaaat atcgatgttt ctgttgtcag catgccttca atggaccgtt 1887421 ttgagaaaca atctgatgaa tacaaaaacg aagtccttcc tgcagatgtg aaaaaacgtc 1887481 ttgcaattga aatgggctca tcatttggat ggggcaaata cacggggctt gaaggtgacg 1887541 ttctcggcat agaccgattc ggtgcatctg ctcctggtga aaccatcatt aacgaatacg 1887601 gcttctcagt tccgaacgta gtgaatcgag ttaaggcatt aatcaataag taagcttttg 1887661 aaagaggatg agtcaaatca tcctcttttt cttgtttatc cgacaaaaat agtattggct 1887721 gtttaacagt aatagacaat tctttctttt cttcttttgt ataatagaga gcaaatgaaa 1887781 tgctgctgga aaaggggatg aaaagatgga acgtcactac tatacgtacc tgatcaaaga 1887841 ggaatttgcc aatcactatt tcggccggga atcggttatg tttgagctgt ttcaagacta 1887901 tcattggaca agccttgaaa agcagcagta tgaaatgaca gagaaacaga ttcaatatat 1887961 tacacaacca atcccgattt tacatatgca tcagcggtta aaaatgaatt taaacaagac 1888021 ggattacagg cagctggatt atatttatag aatagctttg ccgaaagcaa aaggccacgc 1888081 gacgtttatg atgaaggagc acatgataga aattgtggct tcgggagatt acgaggcaga 1888141 aacgatattc tttgaagtgt taagaaaagt aagcccttgc tttttagcaa tggatttcaa 1888201 ttcgaagcgt tacggatggc taaatccggt gaaagaaaga aattttgtct aaaaccgaag 1888261 aaaaagagat gtaaatgttg tataatagct tttggtttag tacactttaa actagacaac 1888321 atgaaggagg aaataaaatg actttatggg ttggcatcct agtgggcgtt gttgcattgc 1888381 tcataggtgt tgcactcggg ttttttattg ctcgtaaata tatgatgagc tacctgaaaa 1888441 agaatccgcc tattaatgaa caaatgttac gcatgatgat gatgcaaatg ggaatgaaac 1888501 cttctcaaaa gaaaatcaat caaatgatga aagccatgaa taatcaaacg aaataatacg 1888561 taaagattat gatatagaga aacatggtta taaaataaaa aacccttata cgggtttttt 1888621 attttgcaat cattcatcac ccgctactgc tcgaaggcgc tgcttttgat attgtatgag 1888681 aagatggtca agctcctgac tgagctctat cgtaatatga gatgtcattc cgttcgccat 1888741 gacaatttgc agcagctctg ctcttttttt ttcaatttct tttaatagat gctctctaat 1888801 cacagggatg tatcctttca tacattagat cttcaaagtg aatgtttata ttatatccat 1888861 atttatacta attttcaaat gagaaggagt ataatgtctc aatgtcaaat taaattatat 1888921 aagttttttc tgaaaataga aatccttcaa gtgaaagtgt taaaaaaatg aaatgatttt 1888981 gtcataactt gaaggaatgt caaatcatga agggatgatg acatgggaga cgtgaattat 1889041 tttttgacat tcggagcggg gtttttatcc tttatttcgc cttgctgcct gccgctttac 1889101 ccagcttttt tgtcatatat tacaggggtc agcatggacg atgtaaaaac tgaaaagctg 1889161 ctgctgcaga aaagaagctt gtttcatact ttgtgttttt tgcttggctt ttcagtcatt 1889221 tttattgctt taggctatgg aacatctttt attggcagcc tgtttaggga ttatcacgat 1889281 gcgattcggc aaattggcgc gttgcttatt attttgttcg gtttcattac actcggtgtg 1889341 ttccggcctg aggctatgat gaaagagcgg agaatccatt ttaagcataa accaagcggg 1889401 tttttagggt cggtcttaat cggaatggca tttgcagctg gatggacacc atgtaccggt 1889461 ccgatattag ctgctgttat cacacttgca ggcaccaatc cgggctcagc ggtgccatac 1889521 atgatgttat atgtactcgg ttttgcggta ccgtttcttt tattgtcttt ttttatcaca 1889581 aagctgaagt ggataaggaa gaaccagctt ttcattatga aagctggtgg cgttttgatg 1889641 attgtgattg gtgtgctgtt attctttaat tggatgagcc tgatcattat tttgctgtca 1889701 gatctttttg gaggctttac tggtttttga cggtaaatta ctttcgtact actactaatc 1889761 cttttgtttt tggtacaata agactattat ctgtggaaat cgattgttgg aggggaatat 1889821 gacaagagtt ttagttgtag acgacgccaa gttcatgaga gtgaaaatca gagagatctt 1889881 ggaagaggca aattacataa tcgcaggcga agcggcggac ggtgaacaag cagctgacct 1889941 gtataaaaaa ctgcgcccgg accttgtgac aatggatatt acaatgccgg tgaaaaacgg 1890001 cataaaagcg cttcgtgata tcttaacctt tgatcctaaa gcgaaggtca tcatgtgcac 1890061 cgccatgcgc cagcaaagaa ttgtaacgga agcaattgag ctgggggcaa aggattttat 1890121 tgttaagccg tttgaggaaa caaaagtgct ggaagctgta agccgcgtta tgggacatta 1890181 aagtcatttc ttttcaaaat ggtttttttt attgttttgg agtatagtat atagtatcaa 1890241 cactccgaga aacaaaggaa tgataagtat gatgattata gtttcatcaa ttattgctgt 1890301 gttaatggct gtagctgtga tggtggtcag aataaagtcc tctgacaagc ctgtttcacc 1890361 aaaaaaaatc attcttccgc cgatttttat gagtacggga gcgttaatgt ttttatttcc 1890421 ggtattttgg gtaactggag cagagttttt ggaagcattc actttaggtg tgattttctc 1890481 tatttttcta atcaaaactt ctaagttcga aattaaaaat aatgaaattt acatgaaacg 1890541 ctctaaagca tttgttttta tattagtcgg tcttttggtg atcagaatcg tgatgaaatc 1890601 gatcttgagc acatcaattg attatggtgc actgagcgga atgttttgga ttctggcttt 1890661 cggtatgatt gtgccttgga gaatcgccat gtatttatca tatcgaaaac ttcataacga 1890721 gctgcagtca tctaatattc aaatgaatta aaaaaccttt cctcttgtca ggaaaggttt 1890781 tttatttgag aagggtctga taaggttcca aatcgatttt tttgtcccgc agatgccttt 1890841 ttaagaaggt atggtctctt ttaggagttg cgagaatata gcctttgatc ataagttgct 1890901 gatcaatctt tgctaccttt tcttttaatg caagctcacc gattttgcct gcgattttag 1890961 cttttgctgc atctctgaac agctctggca cgggcgcagt caattcatct agaaactgtt 1891021 tgttttcatc gttccataaa tgtctgctgt tttcaatata gtaatcctgc caatcaagct 1891081 ctgatctgcc gtcctctttt ggtaaacgct ttaaaaactt tcgaaacatg aaaaaaccgc 1891141 cgattgataa taagactacc atcatgatta cccaaaacag aataaaccat aaaaaccatc 1891201 cttccagcat caatcattcc cccttattct aaccatattg tatacgaaga gagattagaa 1891261 gaacacagta aaaaaagaat agaaaaaagt gatagacgtc tagtcaaaag agatagtaga 1891321 tcatattcta ttgtatagtg aatctgctat ttggccatgg gagagtcact agagggtatt 1891381 tgacgataaa tggacggaaa aaaagtcact ttcataatag gggatgaaag tgacttttta 1891441 tgtttagctg agaggaaatt gaagagaaaa agaagagcca tcttctgttt ctttattgac 1891501 ggcgactgtg agtatttgat tttcgcattc gacttgaatg tttttgtcat taaaataaaa 1891561 aggaagcatc atttgttttt caaaagtctg tcctgacgat ttgacagtta agatgaactc 1891621 gcatccagaa agggtaactg ttacttgtgt aggctgtaaa aaagtcagat ccgcttctat 1891681 aatatactgc tgacttgttt catataaatc aataggcaat gtttcgtcgt accaggcgaa 1891741 ggggtcttca aaaaattgcc gaagccattc atccatacta tcgaaatcat tcgcatcgtt 1891801 gcgttttgaa tggttcatgg aagcattcct ccacatatca accttgcttt acatcatatg 1891861 cggtggatta taaatgggtg aacgcataaa aaaacagaca ctaaggtctg cttttcttac 1891921 atatcatggc ttgagttgtg cttttgtctt gtatggtttc ggttttttac ttttttgctt 1891981 ccgcttagag gctcgggttg gccgggattg tgtcctttag gggcgttttt atgcatatct 1892041 ttacttgtat tcttattggt cataaaatga gaacctcctt aaaagagttc ggtgttattg 1892101 attggttttt ctttttttgt tattttggcg ttctgcttca gtcagtacaa gctggtcgtt 1892161 ttcaatatag ccggcgcctt tgccttggct ttttgcgtca ttcattccgt taatgacgtg 1892221 attcgctttt cttttgacca tcattatcac ctcaatcata atatggcttc ttttattgtg 1892281 ttatatgaga gagcgtaaac agtaaaaatt accggtacat ttttctcata agtcgaactt 1892341 attgtattta ataaaaacat tgatatttac ttatgtatga ttttgtttta atatgaaatt 1892401 gtgagaaaat tgtgatggaa tgtaatgttc atctgagaat gatctgatct gaagggggat 1892461 tttggagaat ggcaaacgag caaaaaactg cagcaaaaga cgttttccaa gcgagaaaaa 1892521 cgtttactac aaatgggaaa acatatcatt actactcttt aaaagcgtta gaagattcag 1892581 gtataggaaa ggtttcgaag cttccttatt ccatcaaagt tcttttagaa tcagtattgc 1892641 gtcaagttga cggcttcgtt atcaaaaaag aacacgtgga aaatttggca aaatggggaa 1892701 ctgccgaatt aaaggatatc gacgttccgt tcaaaccgtc tcgtgttatt ttacaagact 1892761 tcacaggggt tccggcagta gtagatctgg cttcactgcg taaagcaatg gcagctgtcg 1892821 gcggagatcc tgataaaatc aaccctgaaa ttcctgttga tctcgttatc gatcactctg 1892881 tacaggtaga taaagcgggt acagaagatg cattagcagt aaatatggac ttggaattcg 1892941 aaagaaatgc agagcgctac aaatttttaa gctgggcaaa gaaagcgttt aacaattatc 1893001 aggcagtacc gcctgcaaca ggtattgtgc accaggtcaa ccttgagttc ttggcaagtg 1893061 ttgtccatgc cattgaagaa gacggcgagc ttgtaacgta tcctgatacg cttgtcggaa 1893121 cagactcaca cacaacaatg attaacggta tcggtgttct cggctggggt gtcggtggaa 1893181 ttgaagctga agcgggaatg cttggacagc cttcttactt cccagttcca gaggtaatcg 1893241 gcgcgaaact tgtcggcaag cttccaaacg gaacaacagc tactgacttg gcgttaaaag 1893301 taacacaagt gctgcgtgaa aaaggcgttg tcggtaaatt tgttgaattc ttcggaccgg 1893361 gaattgctga actgccgctt gcagatcgcg caacaattgc gaatatggct ccggaatacg 1893421 gtgctacatg cggattcttc ccagtagatg aagaagcgct taactacctg cgcctgactg 1893481 gccgtgatcc tgaacatatt gatgttgttg aagcatactg cagaagcaat ggcttgttct 1893541 acactccaga tgcggaagac cctcaattta ctgatgtggt tgaaattgac ctgtctcaaa 1893601 ttgaagcaaa cttatcgggt ccaaagcgtc ctcaggattt gatcccgcta tctgctatgc 1893661 aggaaacgtt taaaaagcaa ttagtcagcc ctgcaggtaa ccaaggattc ggtttaaatg 1893721 ctgaggaaga aaataaagaa attaagttta aactccttaa cggcgaagaa acagttatga 1893781 aaacgggtgc gatcgccatt gctgcgatta caagctgtac aaatacatca aacccatacg 1893841 tgctgatcgg cgccggactg gtagcgaaaa aagcggttga gttagggctt aaggtgccta 1893901 attacgtgaa aacgtcactt gcaccgggtt ctaaagttgt tacaggatat cttgtgaatt 1893961 caggccttct tccatacatg aaagagcttg gctttaacct cgttgggtac ggctgtacaa 1894021 catgtatcgg gaactcaggt ccgctttcac cggaaatcga agaagcggtt gcgaaaaatg 1894081 atcttctgat tacgtctgtc ctttccggaa accgtaactt tgaaggacgt attcacccgc 1894141 ttgttaaagg caactatctt gcttcaccgc cgcttgttgt ggcatatgcg ctggctggaa 1894201 cggtaaacat taacttaaaa accgatccaa tcggtgtggg caaggatggt caaaacgtat 1894261 actttaatga tatttggccg tcaatggacg aaatcaatgc acttgttaag caaactgtta 1894321 cgccagagct attccgcaaa gagtatgaaa cagtatttga tgacaacaag cgctggaacg 1894381 aaattgaaac aacagatgaa gctttatata aatgggataa cgattcaact tacatccaaa 1894441 acccaccatt ctttgaagag atgtctgttg agccaggcaa ggttgagcca ttaaaaggac 1894501 tgcgtgttgt cggtaaattc ggcgattcag tcacaactga ccatatttct cctgcggggg 1894561 caatcggaaa agatacgcct gccggaaagt atttgcaaga aaaaggtgtt tcacctcgtg 1894621 actttaactc ctacggctcc cgccgtggaa accatgaagt catgatgaga ggaacatttg 1894681 ccaacattcg catcaaaaac caaatcgcac cgggtacaga aggcggattt acgacgtact 1894741 ggccgactgg tgaagtaaca tccatctatg atgcatgcat gaaatacaaa gaagataaaa 1894801 ccggtcttgt cgtattagca ggaaaagact atggtatggg atcttcacgt gactgggctg 1894861 caaaaggaac aaaccttctc ggcatcagaa cggtcattgc agagagcttc gaaagaattc 1894921 acagaagcaa tcttgtattc atgggtgtgc tgccgcttca gtttaaacaa ggtgaaaatg 1894981 cggatacact cggcttaacg ggtaaagaag tcatcgaggt agatgttgat gaaacagttc 1895041 gtcctcgtga ccttgtgact gtaagagcaa tcaatgaaga cggcaatgta acaacttttg 1895101 aagcagtcgt ccgctttgat agtgaagttg aaattgatta ctaccgccat ggcggcatcc 1895161 ttcaaatggt gcttcgtgaa aaaatgaagc agtcctgatg aatcaatagg aagagaaggc 1895221 atttcgcttt ctcttctttt tatgacacaa tgtgctgcgg aggtggcata tgctgaaaaa 1895281 atggctcgca gggatcctgc ttatcatgct agtcggttat acgggatgga atttatatca 1895341 aacatacagc aaaaaagaag tcggaattca agaggggcaa caagcacctg atttttcttt 1895401 gaaaacgcta tcaggagaga aaagctcttt acaggatgca aaaggcaaaa aagtgctgct 1895461 caatttttgg gcaacttggt gtaagccgtg ccgtcaggaa atgcctgcga tggaaaagct 1895521 gcaaaaagag tacgccgaca aacttgcggt tgttgcggta aatttcactt cagctgagaa 1895581 aagtgagaaa caggtccgag cgtttgctga tacttatgac ttaacgttcc ccattctgat 1895641 tgataaaaaa gggatcaatg ctgactataa cgtgatgtca tatccaacga catatatctt 1895701 agatgaaaaa ggtgttatcc aagacataca tgttggcacc atgacaaaaa aagaaatgga 1895761 acaaaaactg gatcttgatt agattcagtt ttttttatac tcaaatatgc ttacaagttt 1895821 tcagaattgg aaaaaataaa agaatatgcg gaggtgagaa gcgtgaagaa gatgagaaaa 1895881 cgttcttttc atgagctcgt catggaaaac aaaaaagagc tgatgaccaa tacagagtat 1895941 ttaaatcagc ttgaggaaaa gcttgaacag cgatttaagc aaaaataacc tttaatttgt 1896001 attcatgttt acccctcctt ttgagaaacc tatctgttga ggagggataa acatgggaaa 1896061 caacaagaaa aacggtcagc ctcaatatgc tccaagccac ttgggtacaa agcctgtaaa 1896121 atataaagcc aataaagggg aaaaaatgca tgatacttca ggacagcggc cgattatcat 1896181 gcagacaaaa ggcgagtagc gaaaattcga gtttatttct aggaggtaca tccgaatgac 1896241 aaagaaccaa aatcaatatc agcagcctaa tcctgatgat cgttctgaca atgtggaaaa 1896301 attgcaggat atggttcaaa atacaattga aaatatagaa gaagcagaag catcaatgga 1896361 gtttgcttca ggagaagata aacagcgtat caaagaaaaa aatgcaaggc gcgaacagag 1896421 cattgaagcg tttcgtaatg aaatacagga cgaatctgca gcgagacaaa acggataccg 1896481 ttcttaaaaa accagggaaa cctggttttt ttctttctga tttgattatg gtaaaatggg 1896541 gctaaattga cgttaaggga gcagagtaat cttgcatgta tcaaaaaaag aaatagaagt 1896601 gcgttatgca gaaacagatc aaatggggat tgtctatcac gcaaattatc ttgtgtggat 1896661 ggaggtcggc agaacggcct tgattaagga cttaggcttt ttatatagtg atatggaaaa 1896721 aaaaggcgtt ctgtccccag tcgttgatat caatatttcc tataaaaagc cgcttcatta 1896781 cggagaaacc gcggttgtac atacatggat agaggactat aacggattta aaaccgtcta 1896841 tggttaccac atttataatc cggccggtga gctttccatc aaagccacct catctcatat 1896901 ttgtgtggat aaagaaagct ttaagccaat tcaattccgc aaagcttttc ctgattggca 1896961 cacagcatat gaaaaggcca aaaaataggg aagtgaacgg gatatggcgt ttggtgtgaa 1897021 acgggaggaa cttaaccggt ggaaacaagc agtgaaaaga ggagaaatcg catttttaac 1897081 acattactgg ctggatgacc gatttccaga agcaaagacc gtgacaaaag ccggctgtgc 1897141 agacattgat aagctggttc agtggggagc ggcgtacggg ttaaaaaaag aatggatcca 1897201 taagaaaagt gaatttcccc actttgatct gctgggggaa acacaaaaat atattttgga 1897261 acaagaaaac ctaaccgatc atcttatacg atttcatttg taaaaaaaga acgcacatga 1897321 agtgcgttct tttttattgg tattcaaaaa ccggttcatc agcgtcttct gaatagctga 1897381 cgagaaggtc gtggttatca aagtaccata aatcactttc ttcaataaag aaggtaatgc 1897441 catcagcttc tgcagtgact ccagcctctt gtggggcatc tttcgctaca ccgagagaaa 1897501 aacccttttg aacgttgctg cagcctccat agcggacgaa aaagcgaacc tggtctccgc 1897561 tttccaaatc gagttcttct ttataccagt tcaatgcgtc ttcgttaatt gtcatattca 1897621 taacagaaca cccctttgtt cttcatttga attttctcta ttataaacgt attaggctat 1897681 tctgtgtcaa aagagaagtt ttttaagctt ataaccattt tactttaggt tctgttttat 1897741 tgataattcg tttaatgttc gctcggtgtc tgtatatcac aaaaatagtg agcagggtaa 1897801 cgacaatcaa taaatacgta tcatggacaa agaaactata tataacagta tagatccctg 1897861 ttaacatcga tgagagagaa acaaatttag tcaagtataa aaagatgaag aataccgcaa 1897921 ccatcgtgat aaataacagg ggtgcgtaaa atagcaaaac gcctcctgat gtcgccacgg 1897981 ctttaccgcc tttaaatttg gcgaagatgg gaaacacgtg gcctaaaacc gcaaagactc 1898041 ctgcaagaag cgggtgaata tcaacatgca tgagaaaagg caatgcagtt gccagtgtcc 1898101 ctttcaaaat atctccggct atgacgaccg aaccagcttt tacacccaat gtacggaatg 1898161 cattggtagc gcctaagttg ccgcttccgt gctcccgaat atcaattcct ttggcaagct 1898221 tgcccacaat taagccagat ggaatgctgc ctatcaagta ggccaaaata atcaataaag 1898281 caattaacat ctacatttct cctttttcaa attcccttct ttttatttta acatgagatg 1898341 tcatgatctg atgataagtt tttttgtaaa gtttgcttac aaatcaaatc aaacatgcat 1898401 catattttga tttctcctgt tttgatcgtg taaaataagt gaaaaaggag tgacacacga 1898461 tgcaaaaccc ttctaaagcg gaaattaaag agattcttca aagaagcaaa cgtatagcgg 1898521 tagtagggct ttcagaccgt ccggatagaa cgtcacatat ggtttcaaaa gcaatgcagg 1898581 acgcgggtta tgaaattatc cctgtgaacc ctacaattga tgaggcgcta ggtgtcaaag 1898641 ccgtttcatc tttaaaagag atagacggtc cgattgacat cgtaaatgta ttccggcgct 1898701 cagaacagct tcctggagtg gcggaagagt ttttagagac agatgcgcca gtattttggg 1898761 cacagcaagg gctagttaat gaggaagcat accagatgct aaaagaaaaa ggcagaacgg 1898821 ttatcatgga tctgtgcata aaagtggcac acgctgtaac aaaataggtg cagaactgca 1898881 aaaatccttg taaattcaag gatttttgct ttttaatttt aagatattgt ttgcgtatta 1898941 cggtgaaaca gatacaataa agcttgaaca gctttttttg aataccttgt ccagctgggt 1899001 ttcggccgtt cgatttgcga aggtctgctg ctttatatat aataaacaaa catacgttct 1899061 catagtgtaa aaacagcact agccgatgtt ttgagaagaa ctgattcgtt agctctatgt 1899121 tgcgattgca aacatattgg ttataatgag gagtccaagg cagtactggc tcgaggcgag 1899181 gtttataaaa aatatcttat atacaaatga tgtgtaacac tgaaaagaga aagacaatgt 1899241 tagtttttga aaggggtttg tacgtttggc tagaaaacag caatttgatt acaacgaaga 1899301 tgccatacag gtgctcgaag gccttgaggc tgtcaggaaa aggccgggta tgtatattgg 1899361 ctctactgac gcgcggggtt tgcaccactt ggtttatgaa attgtagata actctgtcga 1899421 cgaggtgctt gccggccatg gagatcacat aatcgtcaaa atacataaag acaatagtat 1899481 ttctgtacag gatagaggcc gcggcatgcc gaccggaatg cataagctcg gcaaaccaac 1899541 ccctgaagtg attttaacgg tgcttcatgc cggagggaaa ttcggccaag gcggctataa 1899601 gacaagcggc gggctccacg gagttggtgc atcagtcgtg aatgctttat ctgaatggct 1899661 gacggttacc attgagcggg acggttttgt ctatcagcag cgatttgaaa atggaggaaa 1899721 accggttaca tctctcgaaa agatcggcaa aacaaaaaag acgggaactc ttacacactt 1899781 taagccagat ccaacgatgt tcagcacaac cacttataat tttgaaacgc tctctgagcg 1899841 cttaagagag tctgcgtttt tgttaaaagg actgaaaatt gagctgattg atgaacgcaa 1899901 tgaccagcgt gaggtctttt attatgaaaa cggcatagaa gcgtttgttg cttacttaaa 1899961 tgaagaaaaa gacgtcttgt ctgaagtggt ctcgtttgag ggtgagcatc attctataga 1900021 agtggacttt gcgttccagt ttaacgatgg ttattctgaa aatattttgt cgtttgtcaa 1900081 caatgtcaga acaaaagacg gcgggacgca tgagtcaggt gcaaaaactg cgatgacgcg 1900141 tgcttttaat gaatatgcgc gaaaagtggc tttgctgaaa gaaaaggata agaaccttga 1900201 aggcaccgat ataagggaag ggctttcagc cattatttct gtccgcattc ctgaggagct 1900261 tcttcaattt gagggacaaa caaaaggaaa gctcggtacc agtgaagcaa gatcagcggt 1900321 ggatgcgatt gtttcagagc agcttgctta ctttttagag gaaaatcggg acaccgcaac 1900381 gcttcttgtc aaaaaagcaa tcaaggcgag ccaggcgcgc gaagcggcac gcaaagcccg 1900441 tgaagaagca agaagcggca aaaaacgaaa aaaatcagaa gcgactttaa gcggaaagct 1900501 gacgcctgcg ggttcaagaa acccggcaaa aaatgaattg tatctcgttg agggagattc 1900561 agcaggcggg tcagccaagc agggacgaga ccgcagattc caggcggttc tgcctttacg 1900621 cggtaaagtc attaatacag aaaaagctaa gcttgctgat atctttaaaa atgaagagat 1900681 caatacgatc attcatgcga tcggcggggg agtcggggca gatttctcaa tcgatgacat 1900741 caactacgac aaaatcatca ttatgaccga tgccgatact gacggcgccc atattcaagt 1900801 gctgcttctt acctttttct atcgctatat gaaaccgctc attgagcatg gcaaggtgtt 1900861 cattgcgctg ccacctttat ataaggtcag taaaggaagc gggaaaaagg aaatcattga 1900921 atatgcatgg tctgatgaag agatggggga tgtcctgaaa aaagtcggca aaggctatac 1900981 cattcaacga tataagggtc ttggagagat gaacgcagac cagctgtggg aaacgacgat 1901041 gaatccggag tcccgcacac ttgttagggt caaaattgac gatgcggcac gtgtagagag 1901101 acgtgtgacg acgttaatgg gagacaaagt agagccgcgc agaaagtgga ttgagaaaaa 1901161 cgtcgctttc ggcttagatg aagaaagcaa tattttagaa aatgaaaact tatcggtcgc 1901221 tgaggaggtt taatgattgt cacagccaga attatttcat gatttaccat tagaagaggt 1901281 gatcggcgac cgttttggac gctacagtaa atatattatt caagacaggg cgctgcccga 1901341 tgcgagagac ggattaaagc cggtacagcg cagaattctg tatgcaatgc atacagatgg 1901401 aaacacgttt gataaaaact tcagaaaagc ggccaaaacg gtcggtaacg tcatcggtaa 1901461 ctatcatccg cacggtgaca gctcggttta tgaagcaatg gtgcggatga gccaggattg 1901521 gaaagttcgt aatgtgttaa tcgaaatgca tggaaacaat ggaagcatcg acggagatcc 1901581 cccggcagcc atgcgttata cagaggcacg attatctccg atagcatctg agcttcttcg 1901641 ggatattgac aaaaacacgg ttgaatttgt gccgaacttc gatgatacaa gcaaggagcc 1901701 tgtcgtactc ccggcgatgt ttcctaacct attggtcaac ggatctaccg ggatttcagc 1901761 aggatacgcg accgacattc cccctcatca tctgggagaa gtcattgatg ctgtcattaa 1901821 gcgtattcaa atgccttctt gctctgttga cgaactcatg gaagttatta aagggcctga 1901881 ttttccgaca ggcggtatta ttcagggcgt tgacgggata agaaaagctt acgaaaccgg 1901941 aaaaggaaaa atcattatcc gcggaaaggc tgaaattgaa acaatcagag gcggacgaga 1902001 acaaattgtc attactgaaa ttccatttga agtaaataaa gcaaaccttg taaaaaaaat 1902061 ggacgagttc cgtattgata aaaaggttga aggcatctca gaggttcgtg atgaaacgga 1902121 tcgaacaggg ctgagagtgg tcattgaact gaaaaaagaa gctgatgcca aaggcatttt 1902181 gaatttctta tataaaaata ctgatttgca gatcacatat aacttcaata tggtggctat 1902241 ccataaccgc cgtccgatgc tgatgagcct gccgtctatt ttggatgcat atatcggaca 1902301 ccaaaaggaa gttgtcacaa accggtccgt ttacgagctt caaaaagcaa aagacagaca 1902361 tcatatcgta gaagggctca tgaaagcttt gtctattttg gatgaagtga ttgcaacaat 1902421 ccgttcttct agcgataaac gtgacgctaa aaacaatttg atcgcgaaat atgaatttac 1902481 agagcctcag gctgaagcca tcgtgtcatt gcagctatat cgtttaacca ataccgatat 1902541 cacagcgctt aaggaagagg cagaagagct cggtaaaaaa attgaagagc tcgaatctat 1902601 tctgagcaat gataaaaaac tgctaaaagt gattacaaac agcttaaaag cactgaaaaa 1902661 gaaatatgca gatacgagac gctccgtgat tgaagaaaaa attgaagaaa ttaaaatcaa 1902721 tctcgaagtc atggttgcat ctgaggatgt atatgtaacc gttacgaagg atggttacct 1902781 aaaacggacg agccagcgct catttgccgc ttccaacggt caggacttcg gaatgaaaga 1902841 tacggacagg atgctgcatc agtttgaaat gaatacgaca gacgtgctgc tgctctttac 1902901 gaacaaagga agctacatct attgtcctgt tcaccagctg cctgatatca gatggaagga 1902961 catgggccag catttttcaa atctaatcac tattgaccgt gatgaaacga ttgtaaaggc 1903021 tataccgata aaagaatttg atccgtcggc atatcttcta ttctttacga aaaacggtat 1903081 ggtgaaaaag acagagctca ctcattataa agcacagcgt tattctaagg cacttgtagc 1903141 cttaaatctg aagggtgaag atgaactgat tgatgtacat gtaacaaatg gggaaagcca 1903201 gatctttatg gccactcact tagggtatgg tctatggttt ggagaagacg aagtgaatgt 1903261 agttggcgcg cgtgcggcag gtgtcaaagg gattaactta aaagaggatg actttgttgt 1903321 ctccggtgag attcttcagc aatctgattc aattgtcttg ttcacacagc ggggagcggt 1903381 taaacgcatg agtctttctg agttcgagaa gacatcccgt gcaaaacgcg gtgtcgtaat 1903441 gctaagggaa ctgaaaaaga atcctcaccg tgttgtagca ctgttcgctt gcggtcttga 1903501 acagcgacta atggcagaaa cagaaaaagg cgacagaaaa gaactgcaga caaaagagtt 1903561 gcggacaaac gacagataca gcaatggctc tttctttttt gatgaagagg aatcaggcaa 1903621 ggttacagct gtttggcgcc ttcatacaga acaataataa aaaacccgct catactatat 1903681 gagcgggttt cgtttgtttt ttatcagctt tcatggttgg tgaatagatc tgttacagca 1903741 tgaatgactt caatcccctg ccatacaaat aaattcagcg ctgtgaaaga aaataagcct 1903801 aaaatcacca ttcttaagat aaacaacatg tttaacagcc tcctcatatt ttcgttacat 1903861 aatcgggtga tgttgaacat gaagtttgcc gaaataagac gattgataaa atttggccag 1903921 tataaagctt tttttccgct gacgtctgcg ggagtatccc gtacttttgc tttcagcggt 1903981 cagcagcaga acagccattg cccataaagc ggtcagcgta aatgcccctg tgatggattt 1904041 cttctcatca tcagcatttt ggccggcttt catctcatgc atttcctgct ggtcggctac 1904101 ggctttataa tgatggccga tatcaaaggc gtggggaatt gagaacaaat gaaaactggc 1904161 aatcgccaag aataagatgg atgctttcaa tatcgttact tttttcaaat gatctccccc 1904221 tcctttaata ttactgaata tttttataat aataccccaa tccatcctaa aagtaaacct 1904281 gatttattaa atttaaaaat aaatttaact ttgttaagta tatatctttt tgcttatttt 1904341 tgaaagagaa aacttctttt attagcgtat gtatacccgg tttatggtgt gaataaaaac 1904401 atattttaaa tgatatgttg tttaggattt attactttat ttatgtgtaa atcaaagaga 1904461 aaggcaagag aatgggaaga aatgattaca ttgttaatag ggtactcttt ttttaaagcc 1904521 agtttgcaag gaatgttttt attcgtagga aaataataga gaaggggtcg acagagtaac 1904581 atctggctat gacaatattc ttctcgaaaa aacttcctaa ttcgtcatat tgtgatataa 1904641 taaaactcgt tatgttaaaa aatctaacat caaaatcgaa ttcgtattga attgatgaaa 1904701 acgggaggta aatatggagt cttttttcaa tagtttgatt aatattccaa gtgatttcat 1904761 ctggaaatac ctattttata ttttaatagg gcttggatta ttttttacca tacgttttgg 1904821 ttttatccaa ttccgttatt ttattgaaat gttcagaata gtaggggaga agccggaagg 1904881 aaataaaggt gtttcatcta tgcaggcatt ctttatttcg gccgcatccc gagtcggcac 1904941 agggaatttg actggtgtag ccttagcaat tgcgacaggc ggaccaggcg ctgtattttg 1905001 gatgtgggta gtggctgcag taggcatggc ttcaagcttt gtcgaaagta cattagcaca 1905061 gctttataag gtaagagacg gggaggattt ccgcggaggg ccggcctact atattcaaaa 1905121 gggtcttggt gccagatggc ttggcatcgt ttttgcaatc ttaattaccg tctcattcgg 1905181 cttgattttt aacgctgttc aaacaaatac aattgctgga gcattggatg gcgcattcca 1905241 tgtaaataaa atagttgtag ccatagttct ggcggtttta actgcgttta tcattttcgg 1905301 cggtttaaaa cgtgttgtcg ctgtttcaca gctaattgtg ccggttatgg caggcattta 1905361 tattcttatc gctttatttg ttgtcatcac gaatattacg gctttccctg gcgttatcgc 1905421 tacaattgtt aaaaatgctt taggttttga acaagtcgtc ggcggcggaa taggcggcat 1905481 catcgttatc ggtgcgcaac gcggactttt ttcaaacgaa gcaggaatgg ggagcgcacc 1905541 aaacgcggct gcgacggctc atgtatccca tccggcaaag caaggcttta ttcaaacatt 1905601 aggcgtattt ttcgatacat ttatcatatg tacgtccaca gcatttatta ttttgctgta 1905661 cagtgtaacg ccaaaaggcg acggcatcca agtcacacag gctgctctta accatcacat 1905721 tggaggctgg gcgccgactt tcatcgcagt cgcaatgttc ttgtttgcat tcagttcagt 1905781 tgtcggcaac tattattatg gcgagacaaa cattgaattt attaaaacaa gcaaaacatg 1905841 gctgaacatt taccgtatcg ctgttattgc tatggttgtg tatggatctt tatcaggctt 1905901 ccaaatcgtt tgggatatgg cggacctctt tatgggtatc atggcgctga tcaacttaat 1905961 tgtgattgcg ctgctgtcaa acgttgctta caaagtgtat aaagattacg cgaaacagcg 1906021 taagcaagga cttgatcctg tgtttaaagc gaaaaacatc ccagggctga aaaacgctga 1906081 aacatgggaa gatgagaaac aagaagcata atataaatat aaaacaaagc tgcattcaat 1906141 agttgaatgc agctttttca ttattggaaa taaatttaat ttttcgactc gaatgaaaaa 1906201 tgacgtgtaa agtcccaatt cagtccagtt ttctttgttc tatatgtgtc atgtgtgtct 1906261 tattcattgg aggtagagca aattgacagg cttttaaacc tccccaaaac aagaaattag 1906321 gttgatagac aatcatgaga aagattttta caatgagttc gtgctcataa gaagtgtaga 1906381 gccaaaatga tgcgaaggag gaaaagatca gatatgaaac ggtcaatctc tatttttatt 1906441 acgtgtttat tgattacgtt attgacaatg ggcggcatga tagcttcgcc ggcatcagca 1906501 gcagggacaa aaacgccagt agccaagaat ggccagctta gcataaaagg tacacagctc 1906561 gttaaccgag acggtaaagc ggtacagctg aaggggatca gttcacacgg attgcaatgg 1906621 tatggagaat atgtcaataa agacagctta aaatggctga gagatgattg gggtatcacc 1906681 gttttccgtg cagcgatgta tacggcagat ggcggttata ttgacaaccc gtccgtgaaa 1906741 aataaagtaa aagaagcggt tgaagcggca aaagagcttg ggatatatgt catcattgac 1906801 tggcatatct taaatgacgg taatccaaac caaaataaag agaaggcaaa agaattcttc 1906861 aaggaaatgt caagccttta cggaaacacg ccaaacgtca tttatgaaat tgcaaacgaa 1906921 ccaaacggtg atgtgaactg gaagcgtgat attaaaccat atgcggaaga agtgatttca 1906981 gttatccgca aaaatgatcc agacaacatc atcattgtcg gaaccggtac atggagccag 1907041 gatgtgaatg atgctgccga tgaccagcta aaagatgcaa acgttatgta cgcacttcat 1907101 ttttatgccg gcacacacgg ccaattttta cgggataaag caaactatgc actcagcaaa 1907161 ggagcaccta tttttgtgac agagtgggga acaagcgacg cgtctggcaa tggcggtgta 1907221 ttccttgatc aatcgaggga atggctgaaa tatctcgaca gcaagaccat tagctgggtg 1907281 aactggaatc tttctgataa gcaggaatca tcctcagctt taaagccggg ggcatctaaa 1907341 acaggcggct ggcggttgtc agatttatct gcttcaggaa cattcgttag agaaaacatt 1907401 ctcggcacca aagattcgac gaaggacatt cctgaaacgc catcaaaaga taaacccaca 1907461 caggaaaatg gtatttctgt acagtacaga gcaggggatg ggagtatgaa cagcaaccaa 1907521 atccgtccgc agcttcaaat aaaaaataac ggcaatacca cggttgattt aaaagatgtc 1907581 actgcccgtt actggtataa agcgaaaaac aaaggccaaa actttgactg tgactacgcg 1907641 cagattggat gcggcaatgt gacacacaag tttgtgacgt tgcataaacc aaagcaaggt 1907701 gcagatacct atctggaact tggatttaaa aacggaacgt tggcaccggg agcaagcaca 1907761 gggaatattc agctccgtct tcacaatgat gactggagca attatgcaca aagcggcgat 1907821 tattcctttt tcaaatcaaa tacgtttaaa acaacgaaaa aaatcacatt atatgatcaa 1907881 ggaaaactga tttggggaac agaaccaaat tagttaagct tttttttggc ggacatcagt 1907941 aacgatgtcc gtttttatca tctaatagga ggtttgcgtt gtggatgaaa tactgaaaca 1908001 gtatatggtg ctgtataaaa aaatgagtaa tatgataaat ggtcccgact atccaggtaa 1908061 ggaaaaagac atccagcatc aaaaagatca gatcgaagtt tacgaaaaac agctgcagca 1908121 aggattttct acagattatg actatgatgt gtttgctgat tctgttatca aatgcgcata 1908181 tggcgatatg acgctggaag atttagaagc cgtttattat ggattgacaa caccattttt 1908241 ttgatttgtc attcagcagt aaaatttcaa tttctgtctc actaacttaa gtatactttg 1908301 atattgagac agaaatttat ttattttgtt tacttcctag aatatatatt atgtaaacta 1908361 gaaaagatga agaataaagc tttgctgttt ttatgtacat cctttcttct tcctgtaatt 1908421 cagcaacaaa ataaaaaagc gatttcccaa tcggaaaatc gccaattcag acactctatt 1908481 atttatgtgt gtctttgtgc tcttaacgat ttacaacaaa tgttgtcacg ctttgagctg 1908541 gaagatgagc ccaaaaatga ttgcctgata cagtgagatt cgttccaggt tgtagattgc 1908601 tgctgctgct cgtgatccat ctagatacgt ttgaagcaga tccattctgc aaaacaaagt 1908661 tttggttgac tcctgtgttg cttttattga tggcaacaat aacgaccttg ttgtcacctt 1908721 tataggctga cacgtaaacg ttcgcattag ggtttttcgt tgcatcaatc cttacatagc 1908781 cgggacgcac aaactttgag aaatgagcca tattgtagcc gcgtttgctg atcgtaccat 1908841 cttctttcat aggtccatat gatcttcgga tgtaccacca tacataagct tgaaagtccc 1908901 cctctaccat cgcattgtga atatgctgtg aaacatccaa tgcctcaggc catcgatccg 1908961 ccgagttggt atcactgttt ggatagtata cttccgtcat ccaaaggtcc ttccccgctc 1909021 ctttttgttt gaaaagagga taagggaatt ggctgacctg ggtgccgtac aggtgagttc 1909081 cgagaatatc catattggca agagcctgcg gatcgttcaa gatcgggtcc gacaaattct 1909141 tcaagtattg aaatgactca ggcgcaatga cgcgggcatt gatcgagccg gcgttttctc 1909201 tcataaagcg aagtatttct tgcggcgtcc accacgtcca ctcgtgagcg taatcaggct 1909261 cgttttggac cgaaatcgcg taaagattca caccattatt cttcatgaag gtaacaaaat 1909321 cgttaagatg ctgcgcgtat gctgcgtact tgttgtattt cagccgttta gccgatgtgt 1909381 caccattccg attaaaggtc tcaaccatat cacttggagg attccaagga gaagcaaaaa 1909441 cgattgctcc gtgtttgacc gcactctttg cagtctccac ctctttatac caattatttc 1909501 gattttcatc tacatgaatt cttaagattg aaaatcctaa ctggttctgt ccattgccaa 1909561 aagcagtttc tctttgagct gctgtaagat ccccagccca agccggatga ttcatccctc 1909621 caaaaccgcg aatcacttgt ttctctgcag atacattaac tgttacatca cttgctgcca 1909681 aaacttcagt agcgcctggc cctaacatga ctgacagcat agtgaaacat actaatagta 1909741 cacaaattgt tttttttatg cgtggaatca tttattcctc tccttcgtca tgtgtctttt 1909801 acggtattaa aaaatctgca tggcatatcc ataatggcgg gctgttccgg tgctggcccg 1909861 tacttcaccc gcctcgtttt taagcggtcc cattacgagt actatctttg cgtaaactgc 1909921 cagtaatcaa aattaaacaa gtttcctgta cctgttccgg taaatacaaa gaatactttg 1909981 tgcacaccgg ttgccccgct taccgcagtt tctatttccc tccacgtttg cgctccgcct 1910041 gttgaaggca cattcagagt tccaacaagc ttaccgtctg cactgtcgag gcgcacttct 1910101 attttcccgc ctaaagtgga tgctacattt gctttaaatg acctggcacc gcccgctccg 1910161 aagtctgcat ttcctacagc aatccagtct ccattttgaa tgcttgttac atgctgatta 1910221 tttactggcc cgccgggtgc tgtggacttc tctgtcaaaa tgcgtccatt ccaagcaaac 1910281 gtttcagctt ctacccggtt atatgggttt aaattggaaa tttgtgttac acctgcataa 1910341 tttgccgcta cctcttgaat agatccatct gcattatgca ccagcttatt aatatgggga 1910401 gagcggtatc ctttgccggc cccgaacaga gcggaactga cagtttgcgc atggtacacc 1910461 acataccact cgtttttaaa attgaaaaca gcatgatggt tgtttccgcc acctccgaaa 1910521 aatgcacccg gatttttcag gaagtgccct ctatatgtaa agggacccat gggacttgaa 1910581 ctggtcatgt agccgatctc acccgggggt ttatcggccg ggtgcgtgcc gccgaaattg 1910641 atgcaatagg agtaataata tgttccgtta tacttgtgca atcccgaatc ttcaaacatg 1910701 aaaggcgcat caattgtaga tgcacttcca acaacactcg tcatatcagg ccccaatttt 1910761 atgactctag ccgttttagg attggcccat tgtccctgcg ttggatttga aacgccagga 1910821 acgcctccgc cggcatacag gtaaccggtt ccgtcgtcat ctacaaatac tgccggatca 1910881 aaaagccata caacaccaga cattcctggc gtacttggcg ttacgagcgg ttttccgatt 1910941 gggtcggtcc atggaccaat cgggctgtct gcggtgagaa ccccgatacc tccgccgctg 1911001 tttgcgaaat aaaggaagaa tttatccttg ccattaattt ttttaactgc gattgacggt 1911061 gcccatgacg cacctgccca ttttgcaatt ccacggcctc cattagctcc attggcacct 1911121 gctaccggaa tggctccgtg gtctgtccag ttcaccatat ccgctgaaga tatgacgaat 1911181 actctattca aattggcaaa tgaattatct ttaattgttc cgttgctatt atattcatag 1911241 tcatcacttg acatatagat gtagactctt ccgttatagg tcagcgcaac cggatccgct 1911301 cccaaatgat ggtcgataag cggatttgaa ttccctatat gttttgcaat tgtagtacta 1911361 gtggcagcat acgcagactt cccagataag cagctcaata ataaaactag aatccataaa 1911421 catacgctac actttttcct catcacttca catcctcctt tttccttaaa atgggggatt 1911481 ttcttttgga atttgataac aacaggtcac gaagattgca cgcataaagt agccggaagc 1911541 tgtttagcaa tgttcccagt tgttctgaaa gctcatcttc atgtgtctcc attctctctt 1911601 ttcttcgagg agatcgcacc actccttcaa aattgttcaa aaaaacttcc ccattcctag 1911661 cgaccattgt ccagaaaata aaaagacagg attgttcatg gcctcccact aatcacattg 1911721 aacggagatt acatcattat ccaagatatc cctttatcta acatcctaca tcattaaaaa 1911781 aattgtgtat agaaactttt ggaggagtta gtgttcgatt ctacaaagga actggataca 1911841 tttattcatt gataagatgg ggctaacact ccgtttatat ttgtatgttt tcagacacaa 1911901 aaaacagccg ttcaatgcgg ctgttttttt caagagtata agactattga gcggtatacc 1911961 cgctttttca tgttttgttc atattttatt aattgtttat tcaacactgt ccgctatagt 1912021 aatccatatc aacaaatatg actgccactc gcatctttta tgaagggagg ttcgttacgc 1912081 tgaaagaaaa aataaagaca ttaggccgtt tttgcaccgt aggcgtcggc aatacgctga 1912141 tagattttgg tgtcttcttt cttcttaccg cttgtcatgt ctcttatctg ccggcgcaga 1912201 tctgctccta tactgcaggt atcgtcaaca gctatgtgtg gaaccggaat tggacgtttt 1912261 gtgtgaaacg taaggctgac gggaaagaga tcgtgcgttt tctcatgatt aatattgccg 1912321 cgtcagggat cacctttttg ctgctttatt tgtttcaaaa ttgcggctgc tcgcttttgg 1912381 tgagtaagct cgccgccact atcggcggaa tgatgatgaa ttttatcgga aaccgaatct 1912441 gggtatttgg agattcgctg aaaaacatac aggatcagga gtgaagatga atgagaaaaa 1912501 aagtgagaaa agcggttata cccgcagcgg gtttaggaac gagatttctg ccggcgacaa 1912561 aggcgcagcc taaagaaatg cttccaatcg tcgacaaacc agcaatccaa tatattgtag 1912621 aagaggccgc agagtcagga attgaagata tactgattat tacagggaga aacaaacgct 1912681 cgattgaaga tcattttgat cggtcggcgg aattggaatt caatctccgg gaaaaaggca 1912741 agacggagac acttaaggaa atgcagcaga ttgccgattt ggccaacatt cattacatcc 1912801 gccagaaaga accgctcgga ttaggccatg cggtgctgtg tgcggagcat tttatcggag 1912861 atgagccttt tgctgttctc ttaggtgatg atattatggt gtctgaaaca ccggctcttc 1912921 ggcaattaat ggatgtatat gacgtttatg gcacagaggt tgtcggtgta cagtcagttc 1912981 tccctgagga tgtcagcaaa tatggtatta taaatacatc agggtctcaa gggcatgtat 1913041 atgaagtgaa cgatttagtg gaaaagcctt ctcctgaaga agcaccttcg gaaatcgcag 1913101 taatgggacg ttatgtgctg aattcttcga tcttctccgt tttgaagaca attggcagag 1913161 gcgcgggcaa cgaaattcag ctgacagatg cgcttcgtga ggtttgccgt aaggagccga 1913221 tccatgcccg gctgctggaa ggaaatcgat atgacattgg cgataagctg ggctgtttta 1913281 aagcgagcac cgaaatcggc ttaatgcgtc ccgaaatgag atctcagctt ttggcctatt 1913341 tagaagatgt gatcaaacgg gaaacgaaag aaatgctgcg gtaaaaaaat tgtaaccatc 1913401 ttgctcgtca atcagtcata taatagtgaa aaagattagg acaggttgtg aagaatgtgg 1913461 gcagtttgat aagcgaaatt ttaacatggc tgacgaacat gggatatgcg ggtattgcga 1913521 ttgggttaat gattgaaatc attccgagtg agattgtatt agcttatggc ggctatatgg 1913581 tatcggaggg cacgattgga tttattggcg caattattgc gggtgttatc gggggcacca 1913641 ttgcccagat ctttatttac tggatcggtc gctatggcgg caggccattt ctggacaaat 1913701 acgggaagta tttattgatt aaaaagcatc atatcgatat gtcggaaaac tggtttcaga 1913761 aatacggcgc cggagttgtc ttctcggctc gttttatacc ggttgtcaga catgccatat 1913821 ccattccggc aggtattgcc agaatgcctt ttctcaaatt tgtggtactg actgtgcttg 1913881 ctatcattcc atggtctatc ctgtttgttt atttaggcat acagctagga agccagtggg 1913941 atgatgttga gaatatagca ggcacttata caacaccgat tatgatattg gctgttgtcg 1914001 tgatagccct ttattttgtg attaagaaac gtacagccat atttaaacga tagctagcgg 1914061 atatgcatag gggtgactga cgctccccta tgcatatttt tttacttgcg atgttgattt 1914121 gccagcttca gattctccgc taaaaatgcg acaaacactt catcccgcac gagcgatgcg 1914181 gcataatttc tcttaataaa ccattctgcc tcttcaaacg ctgcgaatgt ttcgtcttgg 1914241 gtttctccgt taatttgaat attccattcg ttgtctaaag ggaaaagaaa aaatctcatt 1914301 tgtgcgcgat tttcatataa tgatccattc gcagatccct ttagattata gatgttacgg 1914361 aaggcatccg gccgtacagg atcaatacgg aaagcttcag ctacaaacaa ctcgtatact 1914421 tcatcggtta ttgaacagcc ggacgctttt gcatgccctc cgccgccata tcggccggcg 1914481 atttctgaca catcgatgta atcatgaatg gtgcggagac tgactcgttt tgaccccatg 1914541 ctcaaaatcg caatgtaatc gaggtgcggg ttatctttcc ctagcctgtt ccccagctct 1914601 gaatggtacg attcagcgtg aacgatgcct acacagtgtt cgtgaacaaa ggtttgtacc 1914661 atttcccttt tctttctgcg gaggtagcgc tcgatttttt cgtcttctaa atcaagcagt 1914721 ttttcttcaa aatcatcgaa gaaaaattcg tcatgcgtgg aaaggcgctg gatcattttt 1914781 gcttcaaatt catcgattga cagcaaaaag aaaagatcat taagccgctt cgcctgtttt 1914841 tgatcgtacc gctcccactc ccatgtatcg tattggcgga cgagctctgt gaattgatct 1914901 aaggcgtttg tcggtttcat gaagccattt tcaatgagat agccatataa aagcgatgtc 1914961 gcggatgtga gccttccatc atcgtattcc acctggacaa atccccattc atgctcattc 1915021 aaatgaaggg ctgttttatg atggtcaatg agcttcactt tgccccctgc atgaacatac 1915081 tcattcaatc tctcttcgtt ttcttcattg acggcgagat cggtgatgaa taacgcgtcc 1915141 tgtctgttgc tctccttcgc tttttctaaa aagtactgca cctgtgcgtt taagccgttg 1915201 acagagttat accggatctc tacgtctttt ccgaacgcca attttgctac gattccgcat 1915261 cctactccgt ccaagtcgtt atgtgaatat aaatgataca taatgtaggc ccctttttat 1915321 gataaactga caattgccgc tagaggtgcg gcagccttta tttactattc taaaaaacca 1915381 agcgttttat gcaatggtaa ttagttgaca taatgttgtt attgtaaata tataaaggag 1915441 cgcttttttt gcgctcctaa gttcttgctt ttacaccgga taaaccggat gctttcgatt 1915501 ggtaaatgtc atttcctttg tcatgtatgc cttgagccgt ttggccagct catcacgcag 1915561 cgaattggct gggataacag catcaatgat catttctgaa gccagacggt agatattgat 1915621 gtcctctttg tattcctccc gtttgctgct gataaatgcg gctctctctt cttctggcag 1915681 ctcggcgatt tttttagcgt agacagcgtt tacagcggcc tcagggccca tgacggcgat 1915741 ttgggcggtt gggagcgcta gacagcaatc cggttcaaat gccggccctg ccattgcata 1915801 caaccccgcc ccgtaagctt ttcggacaat gacagagagt tttggaacag ttgcctccga 1915861 catcgcagaa atcattttcg ctccgtgtct gataatccca gcctgttcta cttttgtgcc 1915921 aatcataaaa ccggggatat cggctaagaa cagcaatggg atatgaaaag cgtcacataa 1915981 ggtaataaac ttagccgctt tgtctgctga atcgtggaat aagacgcctc cttttacctt 1916041 cggctggttt gcaacaatgc cgacaggctg tccgtggatt cgtgcgaggc ccgtcaataa 1916101 ttccggtgca aataaggctt tgatctcaaa aaatgagtct tcatctatga cccgctcaat 1916161 gagctcatgc atatcaaaag gtgcgttttg attttgcgga atgacgtcgg caagcggagt 1916221 ttcgaagtgt tttggcgggc gtttctcatg aatgggcgct ttttcttgaa aatttgccgg 1916281 aaagtaagac aaataagccc gcaccagctg tatggcttct tcttcagttt ctgcaagaat 1916341 atctccgcag ccggagattg agcaatgcat acgggcgcca cccatttctt cgagagacac 1916401 tttttctcca ataaccattt ccgccatcct tggcgaacct aaatacatgg aggcgttacc 1916461 gtctaccata acgacgatat cacagaaggc cggaatataa gcgcctcctg ccgcagatgg 1916521 tccgaaaagc agacagattt gcggaatgcg tcccgataat ttgacttgat tgtaaaaaat 1916581 tcttcctgca ccgcgtctcc ctggaaagac attgatttgg tcggtaattc gggcgcctgc 1916641 cgaatcgact aaataaatga gcggacagtt taatttttcg gcgatttctt gaattctgat 1916701 gattttttca actgtttttg ctccccatga ccccgctttc actgttgaat cattcgccat 1916761 gacgcaaacg gtttggccgc cgattttgcc gatagcggtt acaactccgt cagcgggaag 1916821 cccgtctgac atacattccg caaaaaaagc gtcttctagc tcaatgtcat cgtcaaagag 1916881 aagggaaagc cgctctctga caaagagctt gcctttttcc cgattgcttt gatgatactt 1916941 ttccgctccg ccttttcgaa tccgttcagc ccgttctgtt cgttcctttt cataatccat 1917001 cagcattgcc tcccttttat attcccttgt atacggcccg tcttttttct tgaaaggcct 1917061 gaagcccttc tctcctgtct tttgtcggga tggtttgttc atacgctttt tgttcaatcg 1917121 caaggcctgt agcaagatct gtctccaatc ctttattgat tgcaaattta gcctgacgga 1917181 cagcgatcgg tccgttggca gaaatggctg cggccagttc ctctgctttt ggcataaggt 1917241 cacaaggagc cgtgacatgc tctacaaggc cgatttcttt tgcttcgtgt gcggtcacgc 1917301 gtctgcctgt ataaatgaat tcttttgctt ttcctctgcc aatcagccgg ggcagccttt 1917361 gggtccctcc agcgcccggg ataatagcta accctgtttc cggaagtccc agcacagctg 1917421 cttcagttgc gattcgaagg tcgcatgcca atgccaattc tagtccgccg cctaatgcgc 1917481 ttccatttat cgcagctatg accggctgcg gcaaggcatc aagtaaagcc gccgttcttt 1917541 gaatgagaga tacactttcc agaacctgat cttctttcag ttttatccgt tccttcaggt 1917601 ctgcccctgc acaaaacgct ttttcaccgg tgcctgtgag gatgacgcaa cggatgtttg 1917661 agttaaattc aatttcctgg ataatcattt gcaggtttct aagcatttcc gctgaaagag 1917721 catttgctgc ctgaggcctg tttaaggtga tcaacgccat atgttcattt ttaacagtaa 1917781 aaagaataga atctcccatt gtatgcgtcc tcccttttat caagatgatt taaacacctg 1917841 taaatttctg ctcggcagcg gtttgcccat tttttcttca atccatttgg ccgcagatag 1917901 cagtttttct agctttacat ttgttttgat atccatctgt tcaagcatgt acacgatatc 1917961 ctcagttgcg gcgtttcctg atgaacctgg cgcatatggg catcccccaa gcccgcctgc 1918021 cgagccgtcg aacaccgtga tgcccatttg gagtgctgtg accatgttgg ccagagcggt 1918081 tcctctcgta tcatgaaaat gcagggcaat ttgattagcc gggaatcgtg ccaaaagagc 1918141 ttcaagtaca gtttccactt gggcgggatt agctgctcca atcgtatctc caagcgacag 1918201 ttcagaaatc ccaaattcaa atagagcttc tgaaaggcga atgacttgtt caatggggac 1918261 atctttttcg tacggacagc cgaaaacagt cgagaggtag gctcttgttg tgaggtttgc 1918321 tttttgtgcg tcgttgttta cttgtttgag tatatggagg gattcagaag tggatttatt 1918381 gatgtttttt ctgttgtgcg tctcgctggc ggacataaaa acgcaagcct cgttaatgcc 1918441 tccttcaagt gcattctcca gtcctctttg attcgggaca agtgccgcgt acgttacccc 1918501 tttttctcgg tcgatgcctt ttgctacatc gatagcatct cgaagcgccg gaatccattt 1918561 cgggtgaacg aaggatgtga tttcaatata cgacagccct gtccgggaaa gctggttgat 1918621 ccaggttatt ttatcctctg ttgcgatcca aacgggctcg ttttgtaagc catcacgcgg 1918681 gccgacttct ttgattgtca cttttttagg atatggcatg gtcttcctcc aaattattga 1918741 gtggaattgc tcagttcgag cagtacgtct ccttcattta caaagtcgcc ttcctttttt 1918801 ttgacttctt ttacgattcc gcttctatct gcaacgatcg ggatttccat tttcatcgat 1918861 tccaaaatgg ctacctcctg gcccttttcg atttggtcgc cggctttgac gtggactttc 1918921 cacaggtttc ctgccatttg tatgctaacc gtcatgacaa ctgcctcctt tataggtgct 1918981 gtttcaaaaa gtcagtcgtg acatcccctt ctttaaatgc ctttgttgcc gcagcctgta 1919041 tgaggagcgg aaggtttgtt ttgattccct ctacacgata gtcgcgaagc gctgtctcta 1919101 gtttttcaat tgcttctgtt ctggtttggc ctttgacaat catcttagcg atcatcgggt 1919161 cataaaaagg ggtaacggtg ctgtcttttg ctaccgcaca ttcgtgtctg actccttttt 1919221 ggtcaggaag tgaaaacgca gtgatcgtac ctggtgacgg gaagaaggtc ttgggatctt 1919281 ccgcgtatat tcgaacctct atcgcatgcc cgttccgttg gatgtctttt tgggagaatg 1919341 tgagtgtatg gcccgcagca atccgcagct gctgctcaac taagtccagg cctgttattt 1919401 cttcagtcac ggggtgttca acttgcagtc tcgtattcat ttcgaggaaa taaaaatttt 1919461 gtttctggtc aactataaat tcgatggtgc ctgcgttcgt atagccgatt gccttcgctg 1919521 cttttaccgc tgtttgaccg atcttcattc ttagttcatc gtctacaaat ggagacggtg 1919581 cttcttcaat gactttttgg tggcgcctct gaacagagca atcacgttca aacagatgta 1919641 ctgtatggcc gtgttgatcg gccaaaagct gaacctcgat gtggcgcgca tgttcaataa 1919701 ctttttctat atacatagac ccgtcaccga aaaaatctgc tgcgcgcttt ttgtttccct 1919761 cgtacgcttt ttttaatgct tcttcatttt caacacgctg cattccgatg ccgcctccgc 1919821 ccgctgaagc tttcagcatg acaggatagc cgatttgact tgcggtgcgg caggctgcct 1919881 ctatatctcc gagggattca gaaacgcccg gcaccacagg gacacctgca gcctccattg 1919941 cttttcgcgc ttcaattttg ctgcccatct ttgcgatgat atcaggggaa ggtccgataa 1920001 acacgatgtt ttcttgcttg cagcgttcag cgaaccggct gttttctgat aacaatccat 1920061 atcccgggtg gatcgcgtcg gcttttgctt ttttcgccgt ctttatgatt ctctctatat 1920121 ttaaataact ttcactgact ctcgattccc cgatcaaata tgcctctgta gcggcttttg 1920181 tatggggcgc gtccttgtct gcttctgaat aaacagcgac cgttttaatg ccgagacggc 1920241 tgcatgttcg gataattctc attgcaattt caccgcggtt ggcgatcagt acttttgtaa 1920301 acatgatttc acctcattga cttgatgata agttgaacat ttcaatcgtt ttttctcgca 1920361 gtttatattt ttgaattttg cctgaggccg tcatcggata gtcatccgta aaaataacat 1920421 aacgcggaat tttgtggcgg gcgattttcc ctttgcaata ggctttaagc tcatcaggtg 1920481 aaacgctttt accgtctttc agtttaatcc aggctgcagc ttcctccccg aatttggcgt 1920541 caggcacacc aaccacctgt acatctaaaa cagcgggatg ctggtataaa aattcttcaa 1920601 tttcccgcgg ataaatgttc tcgccgcctc tgatgagcat atcttttaat cttccggtga 1920661 tgcggcagta cccgtcttca tccatgacag caagatctcc ggtaaacagc catccgtcat 1920721 gattgattgc ttttctggtc gcatctttgt ctttataata gcctttcatg acgtgatagc 1920781 cacgggtgca cagttctccc tgcatgcctc tttgaacttc ttgacatgtc ccgggttcta 1920841 caattttcac ctcagtatgt ggcagggcac ggccggttgt ttcgactctt cttatgaagg 1920901 aatcatttgc tctcgtttgt gtaatgactg gcgaggcttc ggtttgtcca taggcgatcg 1920961 taatgtcttt catgcccatc ctttcaatca cagctttcat cacttcactt ggacagggag 1921021 agccggccat gattcctgtt cggagcgtcg atagatcata tgcatcaaaa tccggatgat 1921081 gcagctcggc gataaacatg gtaggcacac catggagcac tgtgcatttc tctttttcta 1921141 ccgttttaag gacggtaacg ggatcaaatt cttgcacggg tatcatggct gccccgacgg 1921201 atacacatgc caaaacccca aggacgcatc caaagcagtg aaaaaacgga acagggatgc 1921261 acatgcggtc ttgagaggtt aaagccatac attcagcgat attagcagcg ttattgatga 1921321 cattgaaatg ggtcagcatc acgccttttg gaaaccctgt cgttcctgat gtgtattgca 1921381 tattaatcac attgtcttta tccaggctgt tcattctctc ttcaagctca gcatctgtca 1921441 ctgttttcgc caatatctct gtatcgtccc aatgatacat gccagacaat cgtttattgc 1921501 caatatagat cagcgttttt aaaaagggat agcgttcaga tttcagttgg ccgggctttg 1921561 cttcttgcag ttctggaatt aaactgttca cgatgtctgg ataagaagtg cccctgtatg 1921621 aatccatgat aataagcgcc gcggcatccg attgctttaa caagtaatca agctcatgtg 1921681 cttgataatt ggtattgacg gtcacgagca cggctccgat cttcgcagtt gcgaactgga 1921741 cggcaagcca ttcagagata ttagaagccc atatggcgac gtggtctcct tttccaatcc 1921801 ccatccgcat gagaccttta gcggtttgac ggcacagact gtcaaattga gcgtacgtat 1921861 agcggatatt tcggtctgga tacacaacag catctcgatc gggatacgca tcagctgttt 1921921 gttccagcag cctgccgatt gtggaatgga tgagttcagc cattcattgt tcctcctttc 1921981 ttaatgatag gaaagcgttt acatttttat tttaaaagct gtctggcgat cacgagacgc 1922041 tgaatttcag atgtgccttc accgatttcc attaattttg cgtcccgcag catccgttcc 1922101 accccatact ctttcatata gcctgaacct ccatggattt gaatggcttg attgcaagct 1922161 cttgtcgcca tttcagatgc gaatagcttg gcgtacgccg cttctttggt gaacgggcgg 1922221 ttatgatctt tcagccaggc ggcttttaac accatttgcc gtgccagatc aatttccatc 1922281 gccatgtcag caagcttaaa ttgaatcgct tgaaaggaag aaatcggctg tccaaactgc 1922341 tttcgctctt tcgcatatgc caatgatgcg tcaagggccg cttgggcaat gccgactgca 1922401 agagcagcga tggagattcg accaccatcc agcgtatata gaaactgttt aaaccctttt 1922461 gttggatcgc caagtaagtt ggccgcaggc actcttacat cttcaagcaa gatttccgct 1922521 gtattcgaac cgcggacgcc cattttatcg tacgggctcg taatcgtaag tcctggtgtg 1922581 tcagttggca cgattaatgc ggagatgatg ttttttccgt ctttgttttt gcctgttacg 1922641 gcggttacaa taactgtgcg tgcgtagctt gcattagtga tccagcactt ttcgccgttg 1922701 attacatact cgtcaccatt tgaaatcgct tttgtttgag tgcctcctgc atctgagccg 1922761 gcatttggct ccgtcaggcc gaatgatccg agtgctgtgc ctgaagccag cggcgtcaaa 1922821 tgcgtctgtt tttgctcttc tgttccgaag tagtaaagag ggcttgcgcc tagcgagacc 1922881 gctgcagcat agcttaatcc agtactgccg caggctttgc cgacttcttc aaccgctaag 1922941 gcatatgaaa tcgtatcacc gccagatccg ccgtattctt ctggaaatgg aatacccatc 1923001 agaccgagtt cacccatttt tttaaatgtt tgcatcggga actcgcctgt ttgatctaca 1923061 tgttcagcgt gaggagcaat ttcttttttc gcaaaatctt ttaccatttc acgcaccatt 1923121 tgttgttctt ttgtcagctc aaaattcaca tcgtttcctc cttcacatct ttgtaacatc 1923181 ctattaggcg agttctataa tcattccctg acaagaaaag tctgaaaatt aaaactgaat 1923241 cattttttat gtgataatat cagcgggatg agcaaataca tgcagtaggc gcataccatc 1923301 catatcgtaa acgcaataac ttggcccttt gataaagccg ggaagatgag gggaagattc 1923361 caaagggaaa tcgtatccat caataaaccg accgctgatc cccatatacc tagcttgatc 1923421 accgcgaact gtgattgatc gagtttttga tagagaaaga acacaaggca taaaacaaga 1923481 gcagtgcccg ctcccaagag aagaaagttc ggcaaaaagg cttcttcagc cggatcagtc 1923541 aacacagcat ctccgaacag cacaaaaaat aatgtggcac ctaaccagac tagaaatgaa 1923601 aacgtaaaac acgtcctgta cgtgtttctc ttcgatttta tttttattta gtactagttt 1923661 ctcagattcc aataatggta aatgtccaaa caccgcctcc atattcatgt gaatctcacc 1923721 tttgtttttt aaaaaattca gcggtttacc atcgtttcct gtcccaaaat cactttttaa 1923781 aaaaagacga cttagaaagc cgtccttctc atttcttatt ttgttgttcg tttggaagct 1923841 ttgctttcgt tatgaagccg gtctgctgaa gtgacataat acgtatattt cttgttggga 1923901 tctgccgtgt tatctaagaa ggtttgctgc tcatgtgttt ttctttgcgt tgccagcaat 1923961 gttctctgct ttttcccttc ggctctgtat atcgcataat aggctgtttc tttcgttttt 1924021 tgatttgatg ggtgatcttt aatctgcaga agattgccgt ttttgtcttc ggtgactttc 1924081 gtaagcttcg gtttttttgg ggcggtattg tcaagccaag gcatttgcgg aaccagtgcc 1924141 ggcttgctgt aaagatcggt gctgagactg tctttgatgc caagcggatt tttgttgagg 1924201 tccttgaggc tgaaatgcat gcttcctttc accagttcaa gctggcggtt caaagtgatt 1924261 tgccgcacat attcctcagg atcggaccaa ggcggatcaa aattgttatt gattttatat 1924321 gctgcctggc caatatataa gtgaacaggc ctatttttga cttcattgct ccaccaatca 1924381 gccagcacgt cgtaagccgc tgcgttaaag ccgatactcc aataaatttg cggagcaata 1924441 taatcgatgt cgccttcttg gatccaatgc cttgtgtctg catatagatc gtcataattt 1924501 ctgacgcctg cttttgtatt cgatccggtc gggtcatctg cggcgtttct ccatactcca 1924561 aagggactga tgccgaattt gacatacggt tttgcagctt taattgtttg gttgatttgt 1924621 ttgacaagct ggttcacatt gtcccgccgc cagtcatcga tattagaaaa agcgtctttt 1924681 ccgtattgtt cgtactgtgc ttgatcagga aattcctgtc ccgctatttt ataagggtaa 1924741 aaataatcat ccatatgaac agcatcgata tcataatgtt ttacgacttc ttcaatgcct 1924801 ttgacgataa aatctctcgc ttctggaatg cctggatgat aatacagctg gtttccatag 1924861 gcggcaaccc aatctggatg ttttcttgcc gggtgatcct cagacaattt attaagatct 1924921 gtatgattca ttgtaatacg gtaaggatta aaccacgcgt gaaattccaa atttcgttta 1924981 tgggtttctt caatcataaa tgcaagagga tcatagccgg ggtccttccc ttggacaccg 1925041 gttaagtatt ccgaccaagg cccgtaagct gacggataaa aggcatcagc cgtcggttta 1925101 atctgaacga taacggcatt cattcccatt ttttgcacat cgtccagcag tttgatatac 1925161 tcctgttttt gctctttcac agataaccct tttttggacg gccaatcaat atttaatacg 1925221 gaagcaatcc atacggctct cagctccctg tcagactgcg cattggccat aaacggaacg 1925281 gaaatgacaa acgttccgat gatcaagctg acaaggaaac ggacaatcga cttttggcaa 1925341 accttcattc tgtttcttct cccccattac atcactttca ctattcgcta ttacggtatt 1925401 cccgggctat aaaagggtga ttaacagaat gtctatctca ctaaataaac gaaaaaagtc 1925461 ctaaagcatg ttgtgaaccg cttttaggac tttttatcat tcatcatggt ttgcagactt 1925521 tttaacacat caataagttt tacgccgaca ccgacagccg tttcaaggat cgcttgtgct 1925581 ccggcaatgg ctaaaataaa gatcagcggt attgcaatac gaggcaaaaa aagatagcca 1925641 agtccgatca agatggcaca ccaaacaccg gcacaccagt agcaattgag catgtatcca 1925701 aagttagaag ccggcacgct tttttcatct acatgcccgt tttgatcaac aatccttttc 1925761 tttttcataa aaggttttcg gataaattct gtgattttgt caaatacaat caaatgtgtc 1925821 agcctgtaac tggctagaat cagcatgata aaagttagaa aagaaagacg gtccattgag 1925881 aagcctccaa gaaaaaggat gatgttatca ttcccaagtg tcccttatcc attcttgata 1925941 caaaaagaaa gacggacaga gaatggcctc tgtccgctaa tccgctttat cgtttgtgca 1926001 gtattacttg atttgaagtg atcttttcta aaatgtcgag gatgatgtcg gcattctttt 1926061 cagcatatgt tccttccagc atgtctttat gagcgccaaa acccgtgtac tcactatagt 1926121 ttccgcaggc gccttcccat ttcgttaagc ctgtatgccc gctggtttcg gggtggattc 1926181 cagcttcgat gaaatgaatg cttgctttga tgtggccttc attcagcaat tgtgcccaat 1926241 attcctgata gtttcttttt ttcttcatca ccttttctct gactgcttca ggcagatatg 1926301 ctgcagattc gtcattaccg gtatcgatag gcaaaggctg ttcttttaga taagcgtcca 1926361 cgataatgaa gtcgctgact tctaatcctt tgcgctccat agcctgtgcc acttcaaaag 1926421 ccaggtttcc gcctgcagag tagcctaata aaacgtatgg gccctcaggc tgtatgtccg 1926481 tcatgcaatt aacatattgt tcaatgcggg tgtcttgttc aataaagtga aacccgtata 1926541 cggctgcctt ctcattcagc aataaagcaa ggtctttaaa ataaatgcca aatcccgata 1926601 tcggcgggaa gcagaaaaga ttttgcgcgc cgtgctggtt cagtttgatc acatgctgtt 1926661 catttgctgc tgtcagctgt ttagaataaa gtttttcggc aagctgagcg attgtcggat 1926721 gttcgaacaa gaaatcaatc ggtatgtcaa tgttctgctg atgttttagt gtatgtatga 1926781 cttgcagtgc tcttagtgaa tgtccgccaa tagcaaagaa gtcatcatca atactgattg 1926841 tgttaacacc gaggacttgc ttccaaatgt tcgccaattc ttcttcaacc aagtttcttg 1926901 gcaatatgat gttctgtcgt ttggcaggct tattttctgg aataggcagc gcgctgcggt 1926961 ctatttttcc gtttccggta agcggcatcc gctccacacg cacccagtgc tgcgggatca 1927021 tatagtctgg aagcacacgc gccaaatcgg cgcgaaaatc cgtatctgtt tttttgtgat 1927081 caccgacgta atgagtgtac agctgcgcct ctccatcttt ttctctcaat gtcactgctg 1927141 cttcttgaac gccttccatt tctaacaggc gcgcttctat ttcggcaggc tcaattcgtt 1927201 ttccgcggat tttcatttgc ctgtcaattc tgctgatgta ttctaagttt ccatcaggca 1927261 gccagcgcgc caaatcacca gtacggtata ttctttctcc aggcaagaaa ggatgaggag 1927321 aaaacacagc atttgtcaga tctactctgt tcaaatagcc tttagcgact ccatcaccgc 1927381 caacacaaag ctcgccggga acgcctattg gcaaaagacg tccttttgta tctaagatgt 1927441 aagcggtgct attactgatt ggttttccaa tcggaatcgg ccccgcatag tctctcttca 1927501 tttcaaaaaa ggttgaaaaa gtcgtgtttt ccgttggccc gtaaatatta tgaagcgcga 1927561 gatctggaca ggcgtgtctg acggcattca tcagggcagg agagagtgct tctcctccga 1927621 catataacgt atggagtccg cgaaacatgt cagctcgtac ctgtgccagc tgattaaaaa 1927681 gagctgtcgt taaaaatagc actgtaatgt cattttcaag caaatacgct ccaaaccgat 1927741 caggtgtcag cattgtcgat ttatcaatga tatgaaggct tgcgccattt aaaagtgccc 1927801 cgaacatttc aaaggtgacg gcgtcaaagc tgatagatcc agtcataata aaccggtcat 1927861 caccggacgc agacgtgtaa ttgctgtttc tgacaaggga cacgacattg cgattcgtga 1927921 tcatgacccc tttcggccgg cctgttgatc ctgaggtata catgatgtac gcaagatcat 1927981 ccgggctgga gctgatatta atagggatat cgttctcttc catcaatccc tgcgcatctg 1928041 aaatgataca tgttcctgag aacgcagcgt tttgctccaa tcccttttga acaatcagca 1928101 tttttgcctg cgtttcctca agcataaagc tgactcgttc aggcggaagc tccgcatcaa 1928161 gcgggaggta tgctccccct gcttttaata cggcaagcac actgatcatg aattcgggag 1928221 aatgtgcagc caatattccg gctgtctcgt ttttccgaaa tcccttttga attaactctc 1928281 tggcgagcgc attagagcgt ttatcaagct ctttatacga aatagacata ttgccataca 1928341 caagtgcggt atggtctggc gtcttttctg cttgttcgcg aaataaatcg ataattgtat 1928401 gattctttgg atactccgtt tttgtattgt tgaactgtgt gacaatctgc tctttttctg 1928461 ttgcatcaag aaaagaaaaa tcagcaattg gcatatgagg gtgctgtgca gctgtgctaa 1928521 gcgcttgcgt aaattgcctc ttgatacagc tgatccaggc agcatcgtaa acgaatgcat 1928581 tatagctgaa cttgatgaca agctcttcgc caggagcaac gacaagatta aagttatatc 1928641 ctgattgctc ggatacttga acttgatcga tttgcagcgg tgaatcggtt tgatcagcgg 1928701 aatcggcgat tttctgctgt aacggatagt tttcaaagac gataatgtga tcaatcagtt 1928761 cctgttttaa tgcggtgttt gcctgaatat caaataaagg ctggcaggta aacggctcag 1928821 cttccagcat ttctttctgg cagcgtatga gcagctcgtg aaacgtttcg tcttggtgtg 1928881 ttttaattcg aatcggtatg gtattgataa acaaccctat catttgctcc acgcctggga 1928941 tttctgacgg tcttcctgat acaactgcgc caaacacaac gtcgtctgtg cggttatatt 1929001 gctgcagcat cacaccccag actgcctgaa taagggtagc gagcgtgacg ccgtgttgtt 1929061 tggcagtctc tttcagcttg tctgtcagtg gtttatttaa tgaaaatatc aaatcttcac 1929121 ggtgataact ttcttttgtt tctttatcag acacacgagg cagaggtgat ggagcgctgt 1929181 agttttttaa ataggtatcc cagtaggccg ctgctttttc tttgtctcgg tttgtcagcc 1929241 atgaaatata ggtgctgtac ggacggacag ggtctaatga aagcggtttt cctgcatgaa 1929301 tcgattgata aatttgcata aattcctgca taacgatacc taggcaccat ccgtccatta 1929361 aaatgtgatg gtgactccag atacagacat gctcatcttt agctgttttg aatagagaaa 1929421 tccgcatcag catgtctttt tgcagatcaa agcctttttg cttgtccttc tctttaaagc 1929481 gttcaatata ctcattctgg tcgtttgtcg gcagatgaga aatgtcttcg ctgttcaaat 1929541 ggaattcacg ttctgtcatc acgacttgcc gaggtcccga caaatgcggg acgtgcggca 1929601 aaaacacggt tctgaaaata tcatggcggt cgataatggc ttgaatgctg cgctggaacc 1929661 agtcatagct gaggcttcct ttaatggtga agagcgactg ctcaacatac gccccctcct 1929721 ctttacggag gaaggaatga aacagcatcc cttcctgcat atgactcaga ggataaatgt 1929781 tcttgatttt tttaatggta ttcatagtgt ctgcaccttt cttcacggat tcattagtga 1929841 aaactgagca tatcagcgat ctcttgcagg gcgtcctcgg tcagttcttg atcatcaaaa 1929901 tcactgatcg tcttttctgt ttcgcttttg ttctggcagt gttcgatcag ctgtaataaa 1929961 aattgacggc atgtttcgct aagctgttcg atggttttgc gctgaaagcg ggcattgtca 1930021 taagtcatat tgacagtcaa ttttccttct gcagcgattg cgctgatatc cagcgactgt 1930081 tcacggttcc atgttgtgct gatatcacct ccggcaccca gcggagagaa tgagaaggcg 1930141 tcctcctcag gtacttcagc tgtgcggccg ctttcaaatt gaccaagata attaaagctg 1930201 atttctggtg cacctgtgaa attgatgtct tttttgccag gcggagtcaa atatttgatg 1930261 acaccgtagc cgaatccttt gtcaggtaca cgtctcagtg tatcttttgt tgtttttagc 1930321 acatgaacca tgctttcttc cgaatctggc aagtctgcgt tcagtttaat caataacgga 1930381 taaatggcgg taaaccatcc aatcgtccgg ctcacatcta ttccttttaa tacatcctct 1930441 cgcccgtggc cctctaatga tagtttgaag gcggattgat tggtccaatg gcgcagcgca 1930501 agaatgacag aagcgagcag catgtcctgc gtatcagtgt tatatgcgct gttggcgtct 1930561 tttaagagtg ctgctgtctc tttatcgttt aaggtaaacg aaattgtgga ccgttgtccc 1930621 tcgtgtgctc tagttccatc gatttgatca aaaggcaatg cctctgtttg atactcttcg 1930681 gcttcgcgcc aatacttgag ctgtttcatt agctgctggc tttcagcgta gtcagagagc 1930741 tttttcgcat acgctttaaa cgagcttgtt ttaggcggca gtttgatatc ctccccgcca 1930801 gcagcttggc gataccctaa agccaaatct tcaagcagaa cccgccatga gatgccgtca 1930861 acgacgaggt gatgagcaga taaaaataag aaatcaccgt caattgtgtg gaaaagaccg 1930921 gcttgcagca gcggaccatt cttcaaatcc attttctgct gaatatcaag tacatggcgc 1930981 ttgataagag gttcatacgg tctatttcca tcagtgccgt ccggagctga caaatcaatc 1931041 atctgaaggc cgtacaacgc gtcgtccgaa tgactgagcg gccgattata ttgatcccac 1931101 tttccttgtt cattctgtgt aaacaccatt cgcagcgcat catgatgaca cgttattgct 1931161 tttaacgttt ttcgcagtgc gtcttcttgt acagaggtgc ttcgatgcag cattacggac 1931221 tgattaaaat ggtgtttttc ttttatatct tgagaaagaa accatttttg aacaggcgac 1931281 cattgtacgt ctccctcaac cgcagcttgg ctggaacttg tatctgaatc acggatataa 1931341 gctgccaatt cttgaatggt cggatggcta aacaaatctt tcactgccat ttgcttgcct 1931401 atccggtgaa gccgcgcaga tacctgtaac gctttgattg aatctccgcc aagttcaaag 1931461 aacgaatcag ctgttccgat cttttctgcc cccagtactt ctttccatat atctgccagt 1931521 atttgttcca ttttgctgga tggcgggagg aatggacgtt caccttcgtg gttgtataca 1931581 ggttttggaa gtgctccgcg atccagcttg ccgtttggtg acaatggaag tgagtccagt 1931641 ttttcaataa acgcagggtg cataaacacc ggcagcttgt tttgtaattc tgagcgtaca 1931701 gcatttgtgc tcaaccctgg ttttgtcacc acataagcgc ttaattcggt ttgtcctgac 1931761 gctgttacat gagcaactac tgcggcgtct tttacaccct ttatacaccg gatgaccgat 1931821 tcaatttctt tcgtttctac acggtatcct ctgattttga cttgatcatc gattcttccg 1931881 agatattcga gtgtaccgtc ggccatccat ctggcggcgt ctcctgttcg gtacattcgt 1931941 gcttcgggtt taaatggatt ctgcgtgaat gctctctctg tcagttctgg aagattaacg 1932001 taccctcttg caagccctgt tcctgctata caaagctctc ccgcaacacc gattggctga 1932061 agctgatgat tgctatttaa aatcagcact tgagttccgt caatcggctg gccgatgctt 1932121 acgtatgcct gcttttccat atgtctcatg acggtagtcg ccacgctgtt ttctgtcggt 1932181 ccatattcgt tggcgagttc ggtatgcgga catatagcta agctgcgggc gatcaattcg 1932241 cggtcagccg cttctcccgc cagtgtgacg actctaagcg tctttacatc ttccggctgc 1932301 actacgtcca aaagcgctcg atataaaaca ggcacaataa tcatatgtgt aatccgttga 1932361 cgagacagct gatgcttaat ggccagaata tccttcgctt cctcttcatg aagcaaaacg 1932421 gcttttgcac ctgacaaaag cggtgtaaac atactagtta taaagccgtc aaatgagaaa 1932481 gaaaagagct gcagaatggt atctgtctcg ttgaatgcat aagcgtttcg ccgccactga 1932541 agagtgttag caatcccttt atgctcgacc attacccctt ttggacggcc cgtcgttcct 1932601 gaagtataaa tgatataagc caaatgatgg gcagacgaca tttgcggcag cggcgatttg 1932661 tcgtcttcct ctacgctttc tatcgtcaag atctctcctt caaagtcagc aagtactccc 1932721 agatccgctt catttattgt catcagcagt ttcgttccgc tgtcgctgag gatatagcgt 1932781 ttccgttctt tcgggtattc aggatcaatg ggaacgtaac agcctccggc tttccacaca 1932841 ccaagtatgg atgctatcat actgaacgaa cgatgcatca tgatgcctac tggtgtgtcc 1932901 ggcttaacac ctcggctgcg caatgcacgt gcgattccat tggaccactc gtcaagctcc 1932961 tgataagtga gtgttttgtc tccgctgaca agtgcagaag cttttggtgt tcgtgcagct 1933021 tgctgctcaa acaattgact gattgtttga actccgtatt gattcgcttg cccggtgtta 1933081 aactcattaa gcagctggtg ccgctcttct tgggtcagga tgtcgatatg gttgagtgtc 1933141 accttcgggt ttttgccgat gatgctaagt acatttgtta aatgcgatgc ccagcgttca 1933201 atggtggttt tctcgaacaa tgcggttgaa tattcaaaaa ggaaatgaat gtttccgtcg 1933261 ccctcagatg cctgtagtgt caaatcgaat ttagaaacga gatgagaaac ttgtgccggc 1933321 ttcatttgca aatcatgaag atgcaatggc tcgtaatcat tattttgaac aactaacatc 1933381 gcatcaaaca ctgggttccg gctcatatct cgtgtcaatt caagcttatc gacaagctct 1933441 tcgaacgggt aattctggtg ctcaaaggct tccaatgctg tctcacgcac ttcctgcaaa 1933501 tactgtacga atggcttccc gccctccggg cgcgtccgaa gcgccagcgt gttcacaaac 1933561 atgccgagta tcggctcaag atccttgtgc ggccggccgg cgattggcga gccgacgatg 1933621 atatcttcct gtccgcttaa gcgtgacaag aacgcggtgt aagccgcaag gagcaccatg 1933681 tacagtgtgc ttccgttttc tcgtgccagc ttgtgaaggc ctgatgcaac ctctggttcc 1933741 agcgtaaatg agaccttgtc acccgcgaag cttcgcaccg gcgggcgggc atgatcagcg 1933801 gggagatcca gcacaggcag ctcgccctcg agctgcttca gccagtacgc ctcctgcatt 1933861 ttgtacgcgt ctcctgtttt gaatccttct tgccatacgg cataatcttt atattgaatg 1933921 cgcagcgccg gaagcttccg attattgtac agctcgccga attcttgaat cagaatgttg 1933981 acggaaacac cgtctgaaat gatgtgatgc atatcaacca gcaataggtg ccgctcatct 1934041 gataccttta cgatttgggc acggaacagc ggcgcttggc tgagatcaaa cggtttgata 1934101 aatgcggctg cggcctcctg ttcggttcgt gcgccgagaa ctgtagtctg taacgtaaac 1934161 ggcacctcgt catggatgcg ctgcaccgga tcgcctcctt cgtcctgttc gaaggaggtt 1934221 cgaagcgact cgtggcgctt gatcagctct tggaaagctc tgtccatcct ttcagggttg 1934281 agcttccctt cgagctctaa cacagccggc atattgtagc ctgtccctcc gtcctccagc 1934341 tgctgaagga cataaatccg cttttgggca gaggaaaccg gataggtttc ctgtttttca 1934401 gcgggcttaa tcgcttcata tggactgtcc gttccttcac ggataacggt agccagtcct 1934461 tctaccgtcg gatgggcaaa cacatctttt agcggcacct gtacatcgaa ttctttggtg 1934521 atccgtgaga caagcgccgt tgcttttaag gaatgtcccc cgcggtcaaa aaagttgtcg 1934581 tgaatcccga cagggccatt tttcagcacg tcctcccaca gctgagaaag cttcatctca 1934641 gtcacgtttc tcggcgctgt gtaggtctcc gcatctgccg ctccgccagg agctggcagg 1934701 gcgtttcggt cgagctttcc gcttggcgta accggccact gttccatctc tatcatatag 1934761 gctgggacca tgtagcccgg caacagtctc tcaagctgcg ctcggacttc gtttctttgg 1934821 agcccttcta cataagcgca taattccggc tccccgctgt ctgtccgtac ggtaacggcc 1934881 gcctctctta caccttctat acttcttagt gccgcttcaa tttctcccgg ctcaatccgg 1934941 tagccgcgga ttttcacctg atcatccgtg cgcccgagga attcaacatt cccgtcaggg 1935001 agccagcgcg ccacatcccc ggttttgtac atgcgttcac ccgggtaaaa cgggtcttca 1935061 agaaaacgct cctccgttaa tgccggccga ttcaaataac ctctggcaac acccgctccg 1935121 gctatgtaca gttcgccgat acatccaaca ggcagcatcc gctgattctg attcaggaga 1935181 tataatctga catgatgaac aggttttcca attgggatcc gttcaagttt ttcatgcggc 1935241 ggacaatcaa agaatgcagc ttctacggtt gcttccgttg gcccatagga attggttatt 1935301 gaaacatttg gaagcaactc gtaaaatcgg gagacaagat gggtccccag ctgttctccc 1935361 ccagaaaaca ctcgcttgag tctgtttgtc ttaatcggta cagagcgata ttttatatgt 1935421 tctaaaaatg catggagcat tgaaggcaca aaatgcatag ctgtgatctt ttgttcttct 1935481 atggccttcg cgatcacttc aggttctttt tcgcctccct gaggaagcag ataaacagaa 1935541 gctccggcat aaggccacca aaacagctcc catattgaag catcgaatga atatgatgtt 1935601 ttgtgcataa tcatatctga atgctttagc tgatagcggg actgtaggga attcaaaaaa 1935661 ttcaccgctg atcgatgttc aatttcaaca cccttaggca tcccggtaga gccggatgta 1935721 tagatgacat aggctaaaga ttgcgggaga acatccacat tcggattgga caaacgatgt 1935781 gccagtccgc tatttgtctg attgagatag acaatctctc ctgtaaattc cggaacatga 1935841 aggccggcag actgaagcag gagaatgttt gtaccgctgt cctccagcag aaagctgatt 1935901 cgttcttccg gataatccgg gtcgatgggc agataagcgc cgccagcttt aagaatgcca 1935961 taaatgccaa gcagcatttc aggtgaacgc tttcctataa tggcaacagt cgtttcgggt 1936021 tttacccccc gtccgatcag ctcccaggcg atacggttag cctgttcgtt caattcttta 1936081 taggtcatca ctccatcttc gaagataacg gccgcctgat caggcgtttt ttctgcctgc 1936141 tgttcgagtg catagtggag cgtttgattc attgaatagc ccgtctcctc aaacagatgg 1936201 catgattcaa tgaaatctcg ctcttcttct tttgttaaga ttggaatatt gtccaattct 1936261 gtttcaggac tggcagctgt atgttccaca agcgtggtga aaaggctggc ccacctttgg 1936321 atggtttctt tctcaaacaa agctgtactg tattcaaact gacagaaaag ctcggaatca 1936381 tgctctgtaa cgtataggga aatatcaaat tttgatattg ggtgctccaa gtcgttccac 1936441 tgaagctgta catcattcat ttttagcttt tgctgttcca tattctgaag gactagcgtt 1936501 gtgtcaaaca aaggattccg gctcatttcc cgctgcacac cgagtttgtc cacaagctct 1936561 tcaaacgggt aatcctgatg ctcatacgct tctagtgccg tctgtctgac ttctttcaga 1936621 aattcctcaa atgtcttatt acccgccggg cgtgtgcgga gagccaatgt attgacgaac 1936681 atcccaagaa cagcttcaag gtcggcatgg ggccgtccgg cgataggtga accaatcacg 1936741 atatcatcct gaccgcttaa ccgagacaaa aaggctgaat acaaagcgag aagcgtcata 1936801 taaagcgtgc ttctgttttt atgggcgagc cgctttatgc gggccgtgat ctctttgtcc 1936861 aattgaaagg ttacttttcc gcctatgaat tgccgttctg ccggacgtcg tttatctgtt 1936921 ggaagctcca gtataggaag gtccccgcta aactgctgct gccagtaagt ctcctgcttt 1936981 tggtacgagt ctcccttttt aaatttctgc tgccatacgg cgtaatcttt atattggatc 1937041 cgcaatggct taagctgccg gtttgcataa agatcggtaa attctcggat taggagctga 1937101 acggatacgc catctgaaat gatatggtgc atatccacca gcaatacatg cttctcgttt 1937161 gacacttcta taaggcctgc tctaaataat ggcgcctggc tgagatcaaa gggacggaca 1937221 aatccctcga tagtggtctc tttacttaac gtaaacggca cttcggtgtg gatacgctga 1937281 accggctcgt catcagctcc ggatacaaag gaagttcgaa gcggctcatg ccggctgatc 1937341 agttctttac atacagcaga cagtttggcg acatccagtg caccttccag ttctaagacc 1937401 gcaggcatgt tataggcgac accctcatca agctgttgaa gcacatagat tcgtttttgg 1937461 gccgaagata caggatatgt atcccttttt tctgctggtt caattgctgc atacagattt 1937521 tgttctgcct ctcgaataat taaagctaat ccttcaacag tcggatgagc aaagatgtcc 1937581 ttaagtgaaa cttgcacatg gaattccttt gcgatccgtg acataagcac tgttgctttt 1937641 aacgagtgac cgccattgtc aaaaaagttg tcttggatgc ctatatgccc attctttagc 1937701 acatcttcaa atagttgcga aagctttgcc tctaacagat ttcgaggggc agtatatggg 1937761 tttccgctga ttgaagcatc tggctccgga agtgctgcgc gatctacttt tccgtttggg 1937821 gtaagaggta tgctgtcaac ccatatccat ttcgccggaa tcatgtattc tgggagctca 1937881 ctagccatat aactgcgtaa atctattgtg ttcagctttt gtacactgca atagtaagcg 1937941 cataattcat gttcaccgtt ttgatcttgc cagatgagaa tggcagcctc actaatgtcc 1938001 ggatgattca ttagcgtgac ttcgatttct tgcggctcaa ttcgataacc tctgattttc 1938061 acttgattgt ctgcccgtcc gatatattcg atgttgccgt cttcaagccg tctggccaaa 1938121 tcacctgtcc ggtacatgat cacatcaggc ttgaatggat cggatgaaaa tttgtcgctt 1938181 gtcagtttat cgtgattgac atatcctctg gcaacacttg cgccggaaat atagagttcg 1938241 cctggtacgc cgcatggctg aagctgtttt tgatgattca aaatatatag atcagtacag 1938301 cctatcggtt taccgattgg cggaagctca ggaatagggt ctccaggatg aatggtatac 1938361 gtagatacca catgagtttc tgaaggtccg taatgattgt gcaggtgtat gccgcgttta 1938421 cgcaacacat cttggaaaag gtctgaaatc attaattgtt ccccggctgc gatcaggtgt 1938481 ttgacgccat caggaaacga gttcgcaagt tctcgctcgc tgaaaatcat tttgataaaa 1938541 gcagttggga gaaacacaat attcgtctga tgcttgttta taaatgcaaa cagctgaggc 1938601 acatctcttt ttatggcttc tggcacgatg tggagtgtgc cgcctttcag aagcgcagaa 1938661 aatatttctt gatagcagac gtcgaaggaa ggcgtcgcaa attgcagaac atctgcttca 1938721 aagtcaatgc cggagtgagt atattcgaac ttcagcaagt tagccatgtt tcgatgctca 1938781 aattgaacac cctttggttt acctgttgtg cctgatgtat aaatcatata cagcagatcg 1938841 tcagcattgt tgactgactt tatgttactg ccgtctactt tgctttcgat atcttctgga 1938901 tgagtgataa tgtaattgtc ttctaacgat gagggaagat gcgcttgtga aacaacatgc 1938961 gaacagccgc aatcatgcag aatataacgg attctgtcag cagggtaatg cggatcaacc 1939021 ggaacaatgg cgccgcctgc tttcaagata ccaagaacac ctgtgataaa cgccgctgag 1939081 cgttccatca taatcgcaac gggttcctgt ctcacaacgc ctttcattcg taaatgccgt 1939141 gccaatctgt tagccgcttt attcagttct ctgtatgtta atgagcaggc ttgatcaatt 1939201 acagcatgag catctggtgt cttttccgct tgcttttcaa acatggcatg gatggtttcg 1939261 taaactggtg tttgatctgt gatttctcca atcagctgcc gcttttcagt atctgtcgtg 1939321 atatcgattt cttcaggtgg aagattcgga ttatttaaga tttgtgatac agcattcaga 1939381 agatgctctt tgacagagag cacaaaagac cgatcgtgct gctccgcatc atagttcatt 1939441 ttgatatgaa tttcttcccc tggcgccacc ataagataaa agctgtagtt ggtttcatct 1939501 gcgacagtga aattatgaat ctgaaaaaga tcagaagcat gttcctgttt gttcagcatt 1939561 tgaatctctt gctgcaccgg atagttttca aatacgagaa tatgatcaat cagcccttgc 1939621 ttaacagctg agcgggattg aatctcatat aaagggtggt agctgtacgc ttcagcggca 1939681 agacggtctt tttgcatatc ttttataagt tgaagaaaag gcgtttttgc cccctgcacc 1939741 cgaaccggca tcgtattaat gaaaagacct accatatgtt caatgccttc gatttctgcg 1939801 ggtcttcctg aaatgacaga accgaatacg gcgtcatcgt tattattata tttttgcagc 1939861 agaatgcccc aaatggtatg aaaaatcgta ctgagtgtca cttcttctct agcagcaagc 1939921 tctgaaagcc tgctgctttc ttccttagag aatgaaaatg taacgtgttc ctgcctgctt 1939981 tttccctttg tttttttctg cttcgggagc acggtttgct gttcgtggcc ggaaagataa 1940041 tgatcccaat aagaaaccgc ctgctctttg tcttgctcca tcagccattt gatatacttt 1940101 ccgtatggct ggaccggctc caatgttatt ggggatgcat ttacataaga tgcgtaaata 1940161 tgcagaaact cctttagcac aatgctgagg caccaaccgt ccatcatgat atgatgaaag 1940221 gtccaaatgc aagagtactg gctctctcct gtttgaatca gagcgatgcg catgagcaca 1940281 tccttttgca aatgaaaccc ccggtcccgg tccttttctt tccattgctc gataaactgt 1940341 gattgctccg cctcgtttaa atgagtaatg tcttcttcca gtacgatgac atttcgttct 1940401 ctcagaacaa cctgctgggg ggaggaaaca ttttggctga taaaaatcgt tctgaaaata 1940461 tcatgtcttt ctacaagagc gttgatgctg ttttgaaaaa actgcgggtt gacttttcct 1940521 tctattgtaa aagaagcttg ctcaacatac gcctgtgaat ctttttgcag gagggaatgg 1940581 aaaagcatcc cttcctgcat gtaagacagc ggataaatat cctgaattga attcgctttt 1940641 gtcatgttca tgtctcctgt cacgattttc tacaattctt ccaccaagct ggatatgctg 1940701 tccaagtcct ctgccgttaa tgattgactg ctgaaatcgc tcagtgtctt ttctgctttc 1940761 tgttgaccgg cgcagtgttt cataatgtcc agcaaaaagt gttcaatcct gttaataagc 1940821 tgttccattg tgtttctgtg aaagcgggct ggcggataac taagattgaa atggagcttt 1940881 ttgtctgctg ccattgcact catctcgatg atttgctcgc gcttccatgt atgagtgata 1940941 tcctttccgc taccaaggct tgatgggcgg aaggtgtcct gtctttcgat gtcgttgaac 1941001 tggcccaaat agttaaagct gatttcaggt gtttttgaaa acgtaatgct tttattttca 1941061 gggtgtgtaa ggtatttcag cataccgtaa cctacccctt tgtttggtat ccggcccagt 1941121 gtatctttaa cggtttttac tgaggttccg agctcatccc tatgattttc aaagcttatg 1941181 agggccgggt acatggatgt aaaccagccg accgtcctgc ttatatctaa ctctggcaga 1941241 atgtgttctc tcccgtgtcc ttccatagcg atacggagct tgcttcctcc tgtccattca 1941301 caaatcgcca aggatgctgc ggttaacaga atatcttgtg tatctgtgcc ataggcgtga 1941361 ttgacgtttt gcagcaagac ggcggtgtct gcttcagtca gtgaaaagct taatgagtcc 1941421 cttttgctga agtcgatgtt cacatgatgc ggtatttcat agggcagttc tgcggcttgc 1941481 tgttcttcta cacttcgcca atacgcctct tcgcgaatca gcttactgct ttgggcatat 1941541 tcctgtatgc gtcttgcgta ttcctggtag gaatccgttt taggcggaag ctggatcgtc 1941601 tggcctgcag cagcttgttg atatccggct gacaaatcct ccagcaaaat ccgccatgag 1941661 acaccatcaa cgacaaggtg atggatcgca aggaacaagt aatctccggt cagtgtttta 1941721 aacaaagcgg cgtgcaacaa tggtccttcc tgcaaattga tgctttgctg aagatcggca 1941781 acttcttgtt tgattttcgt ctcccagccg ctttctgact gtgaaagatc agagattctt 1941841 aagctgtata gctgtgactc atgaatgcct tggttgattt gaatccatcg cctgtcatcg 1941901 ttgcgataaa ccatccgaag cgcatcatga tgctccgcca gttttttcaa ggctggtcta 1941961 agggcgtttt cagacaaacg tccagaatgg aatagcatga cagactgatt gaaatggtgt 1942021 ctttcttcaa tatcttgtga aaaaaaccat tgctgaacag gcgtccaagg aacgtcaccc 1942081 tgaatgggtc cttgctctat gattctctct gacttacgga taaatggtga taagtccttt 1942141 atctttggat gacggaataa atcacttacc tgcaagctta gtccatagcg cccaaggcgt 1942201 gcagaaactt gaagggcttt gattgaatct ccgcccaatt caaaaaacga atcctctatt 1942261 ccgatcctct ggatgcctag aacctcctgc cagatcaatg ccagctgctc ttcaagttcg 1942321 ttgcgtggcg ggatgtatgt ttgtttagat gcgacatctg gttcaggcag tgctttccgg 1942381 ttcaatttgc cgtttgatgt gagcggaaga gtctccattt caatgatata cgccgggatc 1942441 atatagtttg gcagcgaacg cgcgagaaga gaacgcactt gttcagcatt cgtgcctgct 1942501 tttacgctga tatagccaaa cagctctttg ctcccggtct gggctgtacg tgctaacact 1942561 gcggcttctt tgaccccgtc tatttgacga agtgctgttt cgatttcacc cagctccacc 1942621 cgatagcctc tgacttttac ttgatcatca atacggccaa cgtactcaat tgtgccatcg 1942681 gaaagccagc gcgccagatc acctgtgcga tacagtcgat cgccaggtgc aaatggatgt 1942741 gggacaaatt tctctttcgt taaatcagga cggcccaaat atcctctggc gacgccatct 1942801 ccgccgacac aaagttcacc gacagctccg accggctgca gcactcccca ttgatttaag 1942861 ataaaagcgg tggaattacc aaccggccgc ccgatcggaa tggaaagttc atatgttttt 1942921 tgaatgtgaa ggcatgtcga aaaagttgta ttttcggtag ggccatatcc attccatata 1942981 gatacttcag ggcagacatt tctgattcga ttgacgtggc tcggcgacaa agcttctccg 1943041 ccaataatca aatgtttcag ctgtgaaaat gtttgttcat tttgctctgt caaatgattg 1943101 aatagagaag atgtcagcca aatcgttgtg attccttgat gttctatgta cctcttaagc 1943161 tgatgggaat cgagaaatgt ttgttgatcg gacagatgca aagcggcacc atttagcagc 1943221 ggtccgaaaa tttcaaatga cccaacgtcg aaaccgattg atgatgtcat cagaaggcgg 1943281 tcttcaggtg taaatgtaat ataattgctg tttttaacaa gacgaattac acttcgctgc 1943341 tcaatcatga caccctttgg tttaccggtt gatccagagg tataaatgat atatgcaagt 1943401 gaatggggcc ctgctgaaga ttcaacgttc ttcgcctctc cttgcttttg aatatcttcg 1943461 attatgattt gttcacattc aatgcctaat agccgttttt ctgttttttc agattgaagg 1943521 agtaatgctg ccctgctgtc agacagcata taagctatgc gttcaacagg cagattagaa 1943581 tcgataggca gataggctcc cccggctttt agaatgccca gcattcctgc aatgagttct 1943641 ggtgttctgc ctgtcaacaa ggctacaaca ctatcaggcc ctacgccctt tatctgtaga 1943701 actgaggcaa tttgatttgc ccagctgttc aggtcctcgt aagtgaatac ttgggtgtcg 1943761 ctgacaattg ctacagcatt aggtgtttgt tctgcctgca tttcaaagag tctgctgatg 1943821 gtttcatttc ttggataatc tatttttgta cgattgagct cgtggataag gtaatgggcc 1943881 tcatcctcat tcaggatatt tattgttccg agagcggctt tgttgtcttt gatgatggag 1943941 agtaacatat tgttgaagta ttgaagccac ttttctatcg tttttttctt atataagtca 1944001 gtactaaact ccatttggaa cgtcagcaaa ccgcggggct gttcctgggc atatagggtt 1944061 aaatcaaatt tggacgtttg atgcccattg tttgctgcag gtttgagaca aagttcatcc 1944121 agctccaacg attcctgatc catattttga agaacaaaca ttacgtcaaa cagcggattt 1944181 ctgctcatat ctcgtgtcaa ttcaagctta tcaacaagct cttcgaacgg gtaatcttgg 1944241 tgctcaaagg cttccattgc tgtctcgcgc acttcctgca agtactgtac aaacggcttc 1944301 ccgccctccg ggcgcgtccg aagcgccagc gtgttcacaa acatgccgag tatcggctca 1944361 agatccttgt gcggccggcc ggcaattggc gagccgacga tgatatcttc ctgtccgctt 1944421 aagcgtgaca agaacgcggt gtaagctgca aggagcacca tgtacagtgt gcttccgttt 1944481 tctcgtgcca gcttgtaaag gcctgatgta acctcttgat ccagcgtaaa tgagaccttg 1944541 tcacccgcga agcttcgcat cggcgggcgg gcatgatcag ccggaagatc cagcacaggc 1944601 agctcgccct cgagctgctt cagccagtac gccccctgcg ttttgtacgc gtctcctgtt 1944661 ttgaatcctt cttgccatac ggcataatct ttatattgaa tgcgcagtgc cggaagcttc 1944721 cgattattgt acagttcgcc gaattcccga atcagaatgt tgacggaaac accgtctgaa 1944781 atgatgtgat gcatatcaac cagcaacagg tgccgctcat ctgatacctt tacgatttgg 1944841 gcacggaaca gcggcgcttg gctgagatca aacggtttga taaatgcggc tgcggcctcc 1944901 tcttcggttc gtgcgccgag aactgtagtc tgtaacgtaa acggcacctc gtcatggatg 1944961 cgctgcaccg ggtcgcctcc tgcgtcctgt tcgaaggcgg tccgaagcga ctcgtggcgc 1945021 ttgatcagct ctttgaaagc tctgtccatc ctttcaaggt tgagcttccc ttcgagctct 1945081 aacacagccg gcatattgta gcctgtccct ccgtcctcca gctgctgaag gacataaatc 1945141 cgcttttggg cagaggaaac cggataggtt tcctgttttt cagcgggctt aatcgcttca 1945201 tatggactgt ccgttccttc acggataacg gtagccagtc cttctaccgt cggatgggca 1945261 aacacatctt ttagcggcac ctgtacatcg aattctttgg cgatccgtga gacaagcgcc 1945321 gttgctttta aggaatgtcc cccgcggtca aaaaagttgt cgtgaatccc gacagggcca 1945381 tttttcagca cgtcctccca cagctgagaa agcttcatct cagtcacgtt tctcggcgcc 1945441 gtgtaggtct ccgcatctgc cgctccgcca ggagctggca gggcgtttcg gtcgagcttt 1945501 ccgcttggtg taaccggcca ctgttccatt tctatcatat aggctgggac catgtagccc 1945561 ggcaacagtc tctgaagctg tgcacgcact tcgtttcttt ggagcccttc tacataagcg 1945621 cataattccg gctcgccgct gtctgtccgt acggtaacgg ccgcctccct tacgccttct 1945681 atgcttctta gtgccgcttc aatctctccc ggctcaatcc ggtagccgcg gattttcacc 1945741 tgatcatccg tgcgcccgag gaattcaaca ttcccgtcag ggagccagcg cgccacatcc 1945801 ccggttttgt acatgcgttc ccccaggtaa aacgggtctt caagaaaacg ctcctccgtt 1945861 aatgccggcc gattcaaata acctctggca acacccgctc cggcaatgta tagttcgccg 1945921 gcgacaccgg aaggctgtac ggctaaatgc ggatctaaaa catacaaacg cgcaccaggt 1945981 acgggcttcc caatcggaat ccgcaaacgg tctctgtccc gttctggatc taacacgtaa 1946041 aatgccgcgt ctaccgtggc ttctgtcggc ccgtagccat ggattaatga tacctgcggc 1946101 aatacagaag caaaacgggc tgccgtacgc ggcgcaagcg gttcacctcc ggcgaataca 1946161 cgctttaggc ttgtcctgtc actcagcctt tcgatttccg cttgatcgag aaagctgttc 1946221 agcatagccg gaataaaatg agccgttgtc acgttttcct gatgaatggc ttgtacgatc 1946281 aatgcggagt ctttttccca gccgggcgga agcagatacg ccgaagcacc ggaaagagcc 1946341 caccaaaaca gctgccacac agacgcatca aaggaaaaag aggttttcac catgacaatg 1946401 tcatcttccg aaagccgaaa ctggtgctgc atgccggtca gaaaggaaac agcctggcgg 1946461 tgctcaacgg ccactccttt cggctgcccg gtagagcccg atgtatagat gacataggcg 1946521 agagatccgt cgctaacaga agcagacaca tgacgtttta cttcttcaca ctcaagagat 1946581 gtcatgtcca cttcaagcgt ttcgccagaa aagtttggtg cggagcatcc cggctgtgtc 1946641 agcaagagcg atgccccgct gtctttcagc atgtagctca gccgctcctt tggatacgca 1946701 ggatcaagcg gcaaatacgc ccctccggcc ttcaatacag caaggacagc gatcagcatg 1946761 tcaggtgagc gttcagacag gacaccgacg atactttcgt ttgtgacgcc gcgtgccgca 1946821 aggtgcgcag ccagccggct ggcgtacata tcaagctcag cgtatgtcag cgaaccgcct 1946881 gaaaagcgaa tggccagccg ctccggtgtg actgccgcct gtcgttcaaa cagcccatgc 1946941 agggttgggg cttcaggtga aacagatact gtcctgttat tttgagaaac gattttccgt 1947001 gttttgtcct catctagcaa cgtcatcttt gacacaggaa gagatggatc agagatgacg 1947061 tcagagacca tgtgcagcaa ataatctttt atttcggaca tcatgcttgg ttgataagcg 1947121 ctggtctgaa aatgaatccg aacgtacaag gtacggcctg ggatcacttt gacactgcaa 1947181 ctataattgg tcacctcttc catctcaaaa tctttgacgg agaaatcaaa tgaccccgct 1947241 tgattcagct cttcgatctc ttgctgggta ggtgtatttt caaagacgat aatatgatcg 1947301 atcaactctt gctttagagc actctgcgcc tgaatatcat acaagggaaa gtaactatag 1947361 gcttctgcct cattcatgtc cttttgcatt ctcctgacta ggtcagaaaa agacagagaa 1947421 tcactttggg ctcgaatagg aatggtattg ataaaaagcc cgaccatgtt ttccacatct 1947481 tttagctcag aaggtctgcc tgatataact gaaccgaaca cagcatcgct gctgcgattg 1947541 accttttgaa gcataatccc ccataaagct tggaaaacag tgtttagtgt cgcaccagaa 1947601 gctgctgcga ttttctgtaa ttcggcggtt tctttttcgg gaatggcaaa cgtgatctgc 1947661 tgtagtgtcc cattcggaat ttgatctgtt cttttcggca ggggtgtaga tttttcgaaa 1947721 tgctgaagcc tctttttcca gtactcagct gcttcttcac gatcttgctg catcagccat 1947781 ttaatatacg tcccgtacgg ctgtacggga ggcaaatcag gaagctggcc tttacccagc 1947841 gcttgataaa tatggagaaa gtctttaatg acgatgccta aacaccagcc atccattaaa 1947901 atatgatggt ggctccagat acagacataa tgatcaggcg cccattttaa aatagatatt 1947961 ctcatcagta catccgtttg gagatcaaag cctttggatt tgtcctgctc tttgaatgcc 1948021 tcggtacaat gttctttatc cctttcattg agatgggaaa tatcttcaat atgaataggg 1948081 caatgacgtt gcttgagcac gacttgacga ggtttggcta catttttata gatgaatgct 1948141 gttcgaaaga tatcgtacct gtcaaaaaca gcatccatac ttttttggaa acgctccaag 1948201 tcaagctgtc catggatcgt aaaagaagcc tgttcaaaat aagctctcga ctgttcatca 1948261 tacagtgagt gaaaaagcat cccttcctgc ataaatgaca aagggtatat atcctgtatt 1948321 tcaggttgct gcggcatcag tgaatctcct ctcctatagt ttgttgacgg ctcccatgat 1948381 ctcactcaat tcatcaagcg ttaagtcttc atcagtgaaa tcagatgcgc tccactcttg 1948441 gttttctttg ccggtacaat gctcaatgat gttttccaga gtctgtttaa aatgcctgga 1948501 aaatgtttgg attgtttttt cctcaaattg aaacctgtta tagatgatgt gcatgttcag 1948561 gcaccccgaa gaaacggcgc cgctgatatc cagtgcataa ggacgctccc agttcgggct 1948621 gatctcattt cctggcttga tgtcagacac ctcaaaggca tttgattgaa tatcctgatc 1948681 aaactggcct aaataattaa agctgatttc tgggctgttt ttctgagagc cccatctttt 1948741 gctgatatat ttcagcacgc cgtagcccgc gcctttatgc ggtatacggt gcagcatatc 1948801 ttttgtctgt ttaataaggt ggcccagccg ctcttctttg tccttatgat cggaatctct 1948861 catatcaagc cacacaggat aaatggaggt gaaccagcca acagttctgc taatatcgat 1948921 gtcctcaaga tatgattccc ttccatggcc ctccatgctg attttaaatt ggttatttcc 1948981 cgtccatttc tgcaaagcaa gacctaaagc tgtcagaagg atatcattca tctccgtgct 1949041 gtaagcttta tgtgcagccg ttaatagtaa ttctgtgtga tggcgagata gctcaaaatc 1949101 aatcacttct gtatctttga atgtgttaga tgctgcgtca ttgtcttttg gaataggctg 1949161 gatgtgacgg ttctcgcact catcccagta cgctgcttcg cgctgcacct ggcggcttat 1949221 agagtagtca gctattcttt gtgaatacgt taaatatgaa tctgtttttt gcggcagttt 1949281 aatagattct cctgagactg cctgtttgta agctgttgaa aaatcctcaa acaaaatgcg 1949341 ccaagaaacc gcatcaacaa ctaagtgatg aatcgttaga aataaatggt caccattctc 1949401 ggttctaaac aatccagcgt gaagtaaggg gccggtttcc aaacgaatat gttcttgcat 1949461 ccggctggct gcttcctcaa tcgtgttccg ggcttctgtt aggctatcct ttacatcaaa 1949521 cagttcaagt gcatatagct cctcatctga aagatctatc cctctgttta tctgcacttg 1949581 cctgccatct tcatgccggc atacgattct cagtgcatca tgatgagtca caaggctttt 1949641 tagtactttt ctaagcgcag cctcatcaaa tcgttcagcc cggtagatca taacggattg 1949701 gttaaaatga tggctttcca gagattgcga gaaaaaccac tgctggatag gtgtccaagt 1949761 aatctcgcct tcgaccgggc cttggtcaat ggcgcgtacg tcttttcgaa cccgggcgga 1949821 cagttcacca agagtctgat gttcaaacat ctcacgtact gtcgtttcaa atccgcgctg 1949881 cttcagtctg gcacaaacct gcagcgcttt aatagagtct ccgccaagct taaagaaatt 1949941 ggcgcttaca cccagctcat ctacattaag aagctcttcc caaatttcag ccatcaccgt 1950001 ttcaatctca tttctaggac tgatatcatc agctgtataa gcttgttttt caggctctgg 1950061 cagggctttc tgatcgagct ttccattaac agtcaccggg atgctgtcaa tttgtatcat 1950121 acgggcaggc agcataaagt caggcaaggc gttttttagg taagttcgga tgtctgatat 1950181 attcgcagcc tgttgatctt ttatcaccat atatgcatat atagctgttt gcccttgctc 1950241 gtctgctctg gtaatgacag ccgcctcttt aatcattgga tactgaagaa gtgccgcttg 1950301 gatttcgcct aactcaatac ggtgccctct gactttcacc tgctcatcaa tgcggcctaa 1950361 gtattccagc tcgccatttg acaggcgctt agcaagatct cctgttcggt ataatctgtc 1950421 tcccggaaga taaggattgg atacaaaacg gtcagcggtc agctcatctc tgttgagata 1950481 tccccgtgcc acaccttcgc cgcctatata cagctcccct ggaactccgg tcggctgcag 1950541 gttcatatgg gcatccatca catgagcctg cagagtagaa agaggccggc cgatattgct 1950601 tttatttttt gcaatgtctg ctgcggacaa ttttttgaat gttacatgga ccgttgtttc 1950661 tgtaataccg tacatattaa tcaaatcagt atgaggatat ttttcattcc agctttgaag 1950721 caatccgggc tgtaaggctt cgccgccaaa aatcacatag cggatgttta aatgatctgt 1950781 atgattttgg tcttcaagca tcaagccgta aaaagcagtc ggggtctgat tgagtacagt 1950841 gacgcgctct ttttttaaca ataatcggaa tgcttggggg tcacgggctg tttctttaga 1950901 gaccacgact aatgtacttc cgttcaataa cgcaccgaac atctcccata cagagaaatc 1950961 aaagcaataa gaatgaaata acgtccagac gtcttcatgg ttaaattcaa aaggcaggtt 1951021 ttgatgcttc aagagactga tcacattgcg gtgctcgaca atgactccct ttggctgacc 1951081 agtcgttcca gatgtgtata tcacgtatgc gggctgatcc gttactattt cttcaatgtt 1951141 tacatcagcc ggaattgagt tgttttcaca ttcatcgata tacaaaatat gcccggtgta 1951201 gtctgcaggt ttgtttagac cgcgctctgt cagcagcagt tttgctccgc tgtcattgag 1951261 cataaagcta atacgctcct tgggatattc aggatcaatc ggcaaatagg ccccgccagc 1951321 ttttaaaatc gataaaacgc caatgatcat atcaggtgac cgatcgagca tcagaccgac 1951381 gatatcgcca gttctgaccc cttgtttgat cagcatagca gctgcccgct cggctttttc 1951441 attcaggtct cgatacgtaa gctgagaatg gccgcacacc actgcgatat gctccggata 1951501 ctgagctact tgcttttcaa ataagcttac tatgttttca tttctcggat aagctgcata 1951561 ctgccccatt ttttcaagga gtaacctacg ctctgcagca ggaagcaatt gcatgttcga 1951621 aattctcatc tcagtatccg ccgttacccc ttttaccaat tcaataaaat aggatgccca 1951681 ctgcgtaatg gtttcttctt caaaaagagc agtgctgtat tcaaaacggc agcgtattcc 1951741 actcagatgc tcctcagcat gtaatgttaa atcgaattta gatatatcat gtttaggagt 1951801 gacagacgaa atcgacagac caggcacttc gaaccggaaa tcttcactgc tttgaagcac 1951861 aagcatcgca tcgaacagcg ggttgcgatt tacctctcga tttgtatcga gcttatctgc 1951921 cagctcctca aaaggataat cctgatgctc gtaagcggtc agagccaggt ggcgaatgtc 1951981 atgcaaatag gagctgaacg ttttgtggcc ctcgggcttg ctgcgcatcg ccaatgtatt 1952041 gacgaacatt ccgatgacgc gctccagatc agcgtgcggt cttccggcag caggcgaacc 1952101 gacaacaata tcctcttgcc cgcttagctt agataacaaa atagaataga cagccagaag 1952161 aatcatatac aatgttgttc ccgtttcagc cattaaacgg tgcagttcat cagccatgtc 1952221 tttatcaatg ttgacttcaa ttgttccacc cctgaaatca gggagacgcg gccttgtttt 1952281 atcaagcggt aattctagtg taggaagact cccgccaagc tgaccgagcc agtaggcctc 1952341 ctgttttttg tatagctctt tcgggtgctt ctcttgctgc caaacagcaa aatccttata 1952401 atgcaggttt aaagctggca actcttttcc gcaatataag tcagtaaatt cttggacaag 1952461 agtgctcatc gagacaccgt cggcaataat atggtgcata tcgagcagca aaaagccgcg 1952521 attattgccc attgtaatga cacatgctct aaaaagcgga ccggatgata gataaaacgg 1952581 tttgataaag gtctcgattg cagactcaag catttgttct gattccattt caagctcttt 1952641 tagatcaaaa gccatctctg gataaatgat ctgcacaggc tcgtctctgt caagcacaaa 1952701 aacagtccgt aatgcttcat gccgattcac aagttctgtg agaacgcttc tcaaccgctg 1952761 gcgattcaga tttccgcgta attcaagtac agctggcatg ttgtagcctg tgctgtcatc 1952821 tgccagctga tgaagagcat ataatcgttt ttgcgagaaa gacagcggat agacatctct 1952881 ttgatccgca ggttcaatct gtgtaaaagc gtgttctttt aagctcatca atttgaccgc 1952941 catgctttca accgtcggat aagaaaacac ctcactgagc ggcagctcga cattaagctt 1953001 tttatgtatt cttgatacca gtgcggccgc ttttaaggac tgtccgccta actgaaagaa 1953061 atcatcacga atgccgatgt gctgtttatt cagcacatct tcccaaatat gtgcgagatc 1953121 agcttcgatt aaggttcggg gcgccatata tgtgacactc gtattgtttt ctggttcagg 1953181 aagcgcaaac ctgtcaagct tgccgctgga tgttaatggc atctggctga tgttgataat 1953241 acttgctggg atcatatagg acggcaatgt cccggcaaga tgctgataca aatctgggag 1953301 gctgtttccc ttttccggaa cgatataagc aacgagctcc ttttcctcag cagaaacatc 1953361 acgggccagt accgctgctt cttttacccc cggtgcttgt cgaagaactg tttcaatctc 1953421 tctcagttca atacgataac ccctaatttt cacttgatca tcaaaacgtc caatatattc 1953481 aatcgttcca tcaggcaaaa agcggcctgc atcacctgtt cggtataaac gctccccttc 1953541 aaggaatgga tgatcggaga atgctttctg tgtcagctct tgctgtttgt agtatcctct 1953601 cgcaagaccc gcgccggaaa tacacagttc acccgccgcg ccgatcggct gcatttgatt 1953661 tccgtgcaaa acaaatactt ttgtgtttct gatcgggtgt ccgatcgtga tcctctcttt 1953721 tttattcaga tgccgcaata ttgttgttgc cacactgttt tctgtgggcc cgtattcatt 1953781 tgccagttca gcagaaggac aaattatttg attcaactca agcagatcag gcgtgaccgc 1953841 ttcacccgca aatgtcacaa tacgaagact ttttgcatcg tcagcagtca tcacttccaa 1953901 taacaccctg tacagggaag gaacaatgat catgtggctg accttataac gggctatttt 1953961 tcgcttaagg gccagcacat ccttcgcttc gtcatctgtt gtcagcagta cgcacgcacc 1954021 agataaaagc ggggtaaata agctcgttac acagccgtca aacacgtacg aaaacaaatg 1954081 gagggatata tcctgttcgg tcatgctata ctcttcccgt ctccattgca atgtattggc 1954141 aataccgtga tgatcaacta aaaccccttt agggcgcccc gtcgttcccg acgtatagat 1954201 caagtaggct agatcacctg gcggcatatt tggcgcttct gtttggtaac tttctgtatg 1954261 ttctatcgtt atcgtatttc cttcatagga cggagggatc aaggaaataa ggtcttcttc 1954321 tatcagcaat tgagccgctt gactgtcctt cagaagaaaa gaaagacgtt ctgctggaaa 1954381 atgtggatca agcggcatat aagcgccgcc tgctttccaa atcccaagca gagctgcagg 1954441 catttccatt gaccggccca tcattacagc aacgatatcc ccagatccaa cgcctttttc 1954501 tatcagggcg tgcgcaatct gattggctct tacttgtaac tggcgatagg tccagcactc 1954561 gtttcccatt ttcaatgcag cagcttcagg tgttttgtga gcttgttcct caaacaattg 1954621 gggtatcgtt ttgttcacat aaggacgctc agtttcgtta aacaattgga taacctgttg 1954681 ctcctccggc ggcacgatat tgatgtcact gacggcaaca tcgggatttg tcaaaatgca 1954741 atccagtgct tgctttagat gcccctgaat cctcagcatc tcctcccgct cgtaaacgtc 1954801 tgcgttgtag ctgaatttga tataaaatga ttctcccgga acgataacga tattaaagtc 1954861 gtaattggtt tgttccgaca ttgaaatgtc actcagcttc agagcgcctt cgtcattttc 1954921 actctccacg cttaatgcct gatgaagctg tacagggtaa ttttcaaaaa caaaaatatg 1954981 atcgatcaac ccttgcttca atggactatg gttttgaatc tcataaagcg gataataccc 1955041 atgctgttca gatgataaaa tatcctcctg cacggctttg accagcgaag aaaatgttat 1955101 gccttccgca gatcggattc gcactggaac agtattgata aacaaaccga ccattgattc 1955161 aatcccgtca atcgctgacg ggcgtcccga aatgacggag ccaaaaacgg catcatctgc 1955221 agcattatat cgatggagca gcacgcccca aatactcata aacagcgtgt ttaatgtcac 1955281 tccccagttt tgggcagcct ctgtcagttt ctcaaccata tccggcgcta atgaaaagct 1955341 gacctggtcg gctttataat tcccgtctgc cgtgcggcgc tttattcggg gaatagaagc 1955401 agtattgccg tactccttca aatattcgct ccagtaggca gcagtctctt cttgatcttg 1955461 ttctccgagc cattcaatat aacggctgta cggcaccgtg ctgccaagct gtacaggtga 1955521 gttatttttg agcgaatcat acatgctgaa aaactcttta agaataatgc cgagacacca 1955581 cccatccatg atgatatggt gatgtgtcca gacacatgta tattggctgt ctcctctatc 1955641 aaaaagggca agacgcatta aaggatcttt ttgcaaatca aatccttttt cccgatcctt 1955701 agtcataaaa gcatcaatca gcgtctgctg ttcttgatca gccaggcgag aaatatcttc 1955761 tctatatact gtcaattcac ggtttgatag aactacctgc tgcggacctg taagatctgg 1955821 tacttcttta atgaaaatcg ttctgaaaat atcatatcta gaaacaagaa ggtttaagct 1955881 cttttgaaac gagtcgacgc atagattccc tgtgatcgta aacgaggtct gttcgatata 1955941 tgctttcgag ctgaaatcca ttagtgaatg aaacagcatt ccttcctgca tgtgcgataa 1956001 cggataaata tcttgaattt gtgccgattg tgccatcaat tccacacacc ttttcaaaag 1956061 ttaaagatct ttcacgagat cttcgatgct agataatgca gacaacgtta attctttatt 1956121 gctgaaatcg ctcaatgttt tttcgcgtgc ttttttctgc gaacaatgct caatcgtctc 1956181 gataagatgc ctgtgaaaac gatccataaa gcactcaatt gagtgtttgc tgaacacttg 1956241 ggtgtatacc gcttttacgt gaagccgtcc gtccgtaatg agagcattga tgtccagctc 1956301 atactctcgt tctctctcac ccgctatttc gtaacggggc tggtaatatg ataattgaaa 1956361 cgtttcaact tccttctctt cgctaaattg accgagataa ttaaagctga cctcaggctc 1956421 tttatgccgc agttctccta tgtgtgttaa caatccgtat ccagttcctt tgttcggtac 1956481 tcttctcagc atatcttttg tcgtcttaat tcggtatgcg agctgatcct cgaaaggctc 1956541 gggaataccc atgtctagca gaataggata aatggaggta aaccatccaa ctgtccttga 1956601 aatatcaatg tttggcacat gcccttctct accgtgtccc tcagtgctga tcacgatttg 1956661 gtcatgccca gtccattcag aaagcgccat tcctaaagcc gtaagcaaaa gttcgttggc 1956721 atcagtacca taggcttgct gggtttcaaa cagcaatttt tcagtccagt ccccggatag 1956781 tacaaacgct gctgcgtcgc tgttcatttg gagtttgtct ggcacatttt ctatgtcctt 1956841 aggaagaaaa gcagtgtgag cgtctaaaat cgtttgccaa tacgttttct ctgaaagcaa 1956901 ttgtttactt tcagctattt gggtaagacc atcggcgtag gataaataag aatccgtttt 1956961 tggcggtaat tggatttctt tcttttctaa agcctgttga tatgctgcag ctaaatcctc 1957021 aagcagaatt ctccaagaaa cgccatctat cacaagatga tgaagtgcaa tcagcaaatg 1957081 atccccttct gccgttttaa acaaacctgc ttgcagtaag ggcccttttt ctacattcat 1957141 tttgctttga atgacggttt cctcagcggc aagtttttca tcaagatgag ccctttccag 1957201 cgatgctttt gtccaatctg aaatataaag gccaaacagt tcatgatcct tgtgattgat 1957261 tccgcgatta aactgaatga catggccgtt ttggtcacgt tggaaaatca tgcgaatggc 1957321 atcatgatgc tcggttattt tacgcagcgc tagatgaagc gcgttagcat tgaatccttt 1957381 ttcactgaaa agcatgacgg actggttgta atgatagtga aaagcatgta cctgtccgaa 1957441 aaatcttcgc tgaatcgggg tgagttcagc ttcaccttcc gcaggtccct ggtccgcttg 1957501 agatgccaat ggtgtgatat gtccgcatag ttcctgaatc gttgaataac ggaataagtc 1957561 gcgtattgtc atgctccagc cttcagctgc cagacgtgct gccacttgta atgctttaat 1957621 tgagtctccg ccaagctcaa aaaaggaatc gtgaatgccg actcgtgaca tgctcagtac 1957681 atcttcccat atatacgcca tcgttttttg taagtcgtta actggtgcgg tatatggacg 1957741 cgataacaca ttatttggag ccggcaaggc atttctgtcc agctttccgt ttagggtcag 1957801 cggcatgttt actaaaggaa tcagatatgc aggaatcata tacgctggca gttcctttgt 1957861 taaagcagca cggagagcat tcgtattgac gtctgaaggc acaatatatg ctgccaaacc 1957921 agcctgtcca tttttatcat gctgaacggc aacagcagct tctctgacaa gccccgtttg 1957981 aagcagaaca ctttcaattt cttctgtttc aattctgtat ccatttatct ttacttgata 1958041 atccattcgg ccaagaagcc ggatcgttcc gtttggaagc cagcatgctc gatcaccggt 1958101 tctgtacagc ctttctccag agacaaatgg attttctgta aatttcattt gcgttaagtc 1958161 aggtttatga tgatagcctt tcgcaacacc tgccccgccg atgcacagct cgccggcaac 1958221 accgatcggc tgaatttgat cagtctggct gagtacgtac atgtgtacat tcggcagcgg 1958281 gctgccgatt ggtacgttat ctcccgtaca ctctccaccc atactggttt catagaaact 1958341 cgaatcaatg gttgcctctg tgacaccata gctattaatg atgcgcatgc tttggccaaa 1958401 gcgatctgtc aatgttttga aatcttgagc tttcaccatg tcggaaccaa gaatcagtat 1958461 gtctaagtca ggaagcttga actggttacg gtatacatac tccatcaccg ggataatgag 1958521 agccggtgtc gactccatca ccgtgattct ctgagattta atgattttat atatttcagc 1958581 aggttccagc cgtgtttcat ctgggcaaac gattagagtc ccgccgttgg tcaatgttct 1958641 cgccaaatct cctgagaaga catcgaatga aaagctcgcg atttgaagca gtctgacagg 1958701 cttccgatcc agttcataaa tttgacgcca agcaagagca gcatgagtaa agttctgata 1958761 ggtgacaata acacctttag gcgcacccgt cgttcctgac gtataaatga tatataccgg 1958821 ctcttcagga gcaggagata agttaaggtt gcagttactt tcttcaaaag agccctcatc 1958881 gtcaaggaag atgtgagaca tctcagattc aggcgagttc gaaatcaaat gcttcaactc 1958941 tctctgtaaa agaagaatat ctgccccgct atcacgaaga atgtattcaa tacgagcttt 1959001 tggataatgt gcatcgattg ggatatacac tccgccagct ttcatcactg ccagaactcc 1959061 aacaattgca tcgatggacc gcttggctaa aacagccaca gttggcttcg gtccttttct 1959121 gttttgcaat gttcgtgcca gacgattggc tctttcattt agaaggcgat agctaatctc 1959181 tgtttcgtta tcaataacag ctatatgttc tggattttct tcagctttcg cttcaaatat 1959241 gcgatgaaaa ggaatatctt tttgagcaaa ttcaacttga gttttgttaa attcaaagac 1959301 tattttttgt ttttctttat cactaagtat gtttatttgt gcaaggcttg tttcaggagt 1959361 tgaaagtgcc tcatgcagaa attcgataaa atgatcagcc cagcgttcaa tcgtagcttt 1959421 caggaatact tctgtactaa attccatttc gcagcaaata gatccactta tttccgtagc 1959481 tattaatgtg atatcaaata aggaaatgtg atgtgcgaaa ttggcaggcc ggacttttat 1959541 ttctctcaga tctatgtctt gtttttccac attttgaagg ataaacatcg catcaaacac 1959601 tgggttccgg ctcatatctc gtgtcaattc aagcttatcg acaagctctt cgaacgggta 1959661 atcctggtgc tcaaaggctt ccaatgctgt ctcacgcact tcctgcaaat actgtacgaa 1959721 tggcttcccg ccctccgggc gcgtccgaag cgccagcgtg ttcacaaaca tgccgagtat 1959781 cggctcaaga tccttgtgcg gccggccggc aattggcgag ccgacgatga tatcttcctg 1959841 tccgcttaag cgtgacaaga acgcggtgta agccgcaaga agcaccatgt acagtgtgct 1959901 tccgttttca cgtgccagct tgtgaaggcc tgatgcaacc tcttgatcca gcgtaaatga 1959961 gaccttgtca cccgcgaagc ttcgcaccgg cgggcgggca tgatcagccg gaagatccag 1960021 cacaggcagc tcgccctcga gctgcttcag ccagtacgcc tcttgcgttt tgtacgcgtc 1960081 tcctgttttg aatccttctc gccatacggc ataatcttta tattgaatgc gcagtgccgg 1960141 aagattccga ttattgtaca gctcgccgaa ttcccgaatc agaatgttga cggaaacacc 1960201 gtctgaaatg atgtgatgca tatcaaccag caacaggtgc cgctcatctg atatctttac 1960261 gatttgggca cggaacagcg gcgcttggct gagatcaaac ggtttgataa atgcggctgc 1960321 ggcctcctgt tcggttcgtt cgccgagaac tgtagtctgt aacgtaaacg gcacctcgtc 1960381 atggatgcgc tgcaccggat cgcctcctgc gtcctgttcg aaggaggtcc gaagcgactc 1960441 gtggcgcttg atcagctctt tgaaagctct ctccatcctt tcagggttga gcttcccttc 1960501 gagctctaac acagccggca tattgtagcc tgtccctccg tcctccagct gctgaaggac 1960561 ataaatccgc ttttgggcag aggaaaccgg ataggtttcc tgtttttcag cgggcttaat 1960621 cgcttcatat ggactgtccg ttccttcacg gataacggta gccagtcctt ctactgtcgg 1960681 atgggcaaac acatctttta gcggcacctg tacatcgaat tctttggcga tccgtgagac 1960741 aagcgccgtt gcttttaagg aatgtccccc gcggtcaaaa aagttgtcgt gaatcccgac 1960801 agggccattt ttcagcacgt cctcccacag ctgagaaagc ttcatctcag tcacgtttct 1960861 cggcgccgtg taggtctccg catctgccgc tccgccagga gctggcaggg cgtttcggtc 1960921 gagctttccg cttggcgtaa ccggccactg ttccatctct atcatatagg ctgggaccat 1960981 gtagcccggc aacagtctct caagctgtgc acgcacttcg tttctttgga gcccttctac 1961041 ataagcgcat aattccggct ccccgctgtc tgtccgtacg gtaacagccg cctctcttac 1961101 gccttctatg cttcttagtg ccgcttcaat ttctcccggc tcaatccggt agccgcggat 1961161 ttttacctga tcatccgtgc gcccgaggaa ttcaacattc ccgtcaggga gccagcgcgc 1961221 cacatccccg gttttgtaca tgcgttcccc cgggtaaaac gggtcttcaa gaaaacgctc 1961281 ctccgttaat gccggccgat tcaaataacc tctggcaaca cccgctccgg caatgtacag 1961341 ttcgccggcg acaccggaag gctgtacggc taaatgcgga tctaaaacat acaaacgcgc 1961401 accaggtacg ggcttcccaa tcggaatccg caaacgatcc ctgtcccgtt ctggatccaa 1961461 tacgtaaaat gccgcgtcta ccgttgcttc tgtcggcccg taaccatgga ttaatgatac 1961521 ctgcggcaat acagaagcaa aacgggctgc cgtacgcggc gcaagcggtt cacctccggc 1961581 gaatacacgc tttaggcttg tcctgtcact cagcctttcg atttccgctt gatcgagaaa 1961641 gctgttcagc atagccggaa taaaatgagc cgttgtcacg ttttcctgat gaatggcttg 1961701 tacgatcaat gcggagtctt tctcccagcc gggcggaagc agatacgccg aagcaccgga 1961761 aagcgaccac caaaacagct gccacacaga cgcatcaaag gaaaaagagg ttttcaccat 1961821 gacaatgtca tcttccgaaa gcggaaactg gtgctgcatg ccggtcagaa aggaaacagc 1961881 ctgacggtgc tcaacggcca ctcctttcgg ctgcccggta gagcccgatg tatagatgac 1961941 ataggcgaga gatccgccgt cagcaggagt aaactcatgg ttttctgctt tttcgctcgc 1962001 aagagatgtc atgtccactt caagcgtttc gccagaaaag tttggtgcgg agcatcccgg 1962061 ctgtgtcagc aagagcgatg ccccgctgtc tttcagcatg tagctcagcc gctcctttgg 1962121 atacgcagga tcaagcggca aatacgcccc gccggccttc aatacagcaa ggacagcgat 1962181 cagcatgtca ggtgagcgtt cagacaggac accgacgata ctttcgtttg tgacgccgcg 1962241 tgccgcaagg tgcgcagcca gccggctggc gtacatatca agctcagcgt atgtcagcga 1962301 accgcctgaa aagcgaatgg ccagccgctc cggtgtgaaa gctgcctgtc gctcaaacag 1962361 cccatgcagg gtgaaagctt taggcgaaac agcttccgtc ttgttaaact catacaacaa 1962421 tttttgcttt tctcttgtat tcgtcatatc taattctctt ataaagctgt gcggatgttt 1962481 aagggcgttt tccagtatgg taagcagatg agattgtatt cgtttaatat cctcaagaga 1962541 aaacaaggta ttttgatagt cgaaatttaa ttgaatggtt ccattgtcta tccgttcttg 1962601 tatttgaact gaaagttcgt tcgcggtgta tccgctgaaa taaagcgctg tttcatagtc 1962661 aaaatcatct gcattgtgcc actgaagtgg ctgatactgc atagatatac cgataaggtt 1962721 gtgtaaatcc ttctgttcat ttcttaattc atttacaagc aaattataag gaaaccgttg 1962781 atgacgcata acagaaagct gttccctgcc tattgtgcgg acaaaggaaa gaaaatctgt 1962841 gtcaggatca accgttattc tgattggaag ggaactaacg aacatgccga gcatttcttt 1962901 ttcagccttt gaacctctgt tgccatagta ggtgccaatg gcaagatctt ttttagaagt 1962961 gattcggctg atgcatatgt aaaatgaagc cataaataag gaaatgatat tgatcttgtg 1963021 ttcttcgcag aagattcgaa tcgtttgctc tagatcaggt gaaagaatga tggtgtctct 1963081 ggatgcagat gtgctctgtt tttgtaagga cgtctggtcg gctaacgagt ggtattccaa 1963141 cgggtgctca aaggtttgcg tccaaaataa acggtccttt gcaaaccgtg gagattgtag 1963201 atattgactc tctttttcga tgtagctcaa gtaagaaggt tccggctgat caggtaaagg 1963261 atctttcttt ttcatttttt gataaagatc tataatttga tttcccatca catttaaaga 1963321 gattccatcc attatgatat gatggaattt cgcaaatagc caaacttcat gagagtcaat 1963381 tctaaggagg taaaattgaa aaagaggcga gttgaacagt ttaaatggaa tgctcgcttg 1963441 atcctgaatc cattgctcta tttctatcat ttcaacattt gaaaaatcaa ttattctaag 1963501 tggataatat ttatattcag taaggtgcaa tcgaggctca agctcttctc cttctaacag 1963561 ctgaaatcta atggcgtcgt tgcgggagat ggaatgattc agtgctccct ccagagtatc 1963621 aagctcaata ttgcctttaa atttcacaca agctgtaaga ttgcaaatgc tggtatctgg 1963681 ctccagcagt tcggtaaacc acactctcct ttgggcatgg gttaaagaat aagtatgttc 1963741 gctcaacgga ttccctccag ttctcataat aagaggataa gaaaatgtag aaaaaagcag 1963801 aaaaatgaca ataaaagaaa ttatatgact atataatcca tatatgcact atattaacgg 1963861 atatttttta aagtacaata aaaaacatta aatttttata acattttttt tgaatatagt 1963921 attatttctt tatttttcgt ttcttttttt atcaaatttc cggatataaa gtgataaaag 1963981 tattgtttta cataaggtct tatacactac tttttaatcg gactaatttt cttttgtgca 1964041 tcattcttct aattgttgga aggttcgaca aagcgttatt acagacataa aaaaacctgt 1964101 tttctcttgg aaaacaggtc tcccgctatt attgatttgc caaaatgaca gcgatttgat 1964161 cctcaatatc ttttccatcc tcttcatcaa tcaatccatt tagaagaata gagaaaacaa 1964221 gtttttttcc gctctttgtt tctgcgtacc ccgatagaga gcttaccgta ctgagcgatc 1964281 cggtttttgc tcttactttt ccttgtgcag gagtgccttt catgcggttt ctcagcgttc 1964341 cgcccaccat tctgtcagga ttccccgcaa caggtaaaga atttagataa gccgagaacc 1964401 aactctgatc ctgaatgtca tataacagct gtgaaagttg atctgaggat acagcatcaa 1964461 tatgtgagat tcctgatccg tcccttaaga cgagtgattt agaatcaaca ccaaattccg 1964521 gaagcgtact gtttaacact tcgagcccct tttcccagct cccttctcct tttttcactt 1964581 tccccatctc ttttacgagc acttcggcat gtccgttatt acttaatttc atgaacggca 1964641 caaaaagttt cgataaaggc attgagcgat gagagagcag cacatctgaa gaactaggtg 1964701 cttcacccgt cttgatgtcc cctttcacag taataccttg tttttttagt gactgcttaa 1964761 ataaatctaa ggcatatccg gcaggctccc agacagaaat ccattccttt gtcttgtttg 1964821 cgtcaaccgg tacgctccct tcaattgtaa tcgtgtttgt tccatgctct ctttcgattg 1964881 tgaggtcttt ctctgaaccg gcagcagtcg ttttagcatc gttctttatc gttatataat 1964941 cggttttcgg agagacagac acggcaggct cttccccttc tttttgattt ggggtgacct 1965001 caacaatcac agtgcctgca tcatagtctt cgtttggaga cgctgttaga gcggagattg 1965061 gcgcgccata atatgtgtat tcatcgctcc aaggcatatc aggtgataat cgcatgtcat 1965121 catgccacgt atcatcaccg atcagattgc ctttaattac ttttacgccg gaatgtttca 1965181 atatctcagc cattttgtca aaatcagatg gtaaaagtgt cggatcgcct ttccctttca 1965241 aataaaggtt accattcagc tttttccctt tcagtgttcc atccgtccgg acctcggttg 1965301 taaaagaata gttctcgcca aggacagaaa gtgccgcggc cgctgtcaaa agctttagag 1965361 aagaggcagg cctcattcgg gtgtctcctg aatgttcata tagaacagca cctgtttccg 1965421 cagagcgaac ggtgatgccg gccattgcgc cttcgagggc aggatgatca gctaaaatct 1965481 tatcgatctg cccggaaagt gcatcttgtt tttcagcggc aagcgcagcc tgatgcatat 1965541 aaggcaccga agcaacgacg aaaagcagta aaacagcaac ataaagcttt atgctttttt 1965601 tcattaattt ccccgcctct ctgcgcttca tcattggcta ttgatgattc agttcaatgg 1965661 tgatactgct tttagctgtc gtttcttctc ccggctccag cacttgtaaa ccagtgagtg 1965721 acgaaggtaa atcaagattc actgcgtttg tcacccatgt gtaaggctca gggcataaat 1965781 acccttgttt tccgtccgca ttgtatacaa cccaatgttt aaactgttca tctgccttat 1965841 aaataatgct gatatgtgca tgctgatgat aaatgactgc ctggttttct ccgcccctct 1965901 tctgataaga agataaaaag acatcatcca gctgcttgtg gcgcaaatcc attccttcat 1965961 gcaaagcttc tttatacggg acatccatca gcttcccggt cggcagcagg cgttcatcca 1966021 actcccattg ctgatctgct gtcagggaga ataacgagct ttctgccgga aatataaatg 1966081 tagtatgata accaattccc caaggaaacg cttcctttcc tttgttcatg accgtcgcat 1966141 gtttaaatag ggtattctcc ttgatcgtgt atgtcatccg aacgacggca tgatgaggaa 1966201 attgcttctg cacatgggga agctcagaaa gatcaatttc tgtttcaaca atcactcctt 1966261 catcagtttg cttcgtggtc acgacattcc acttttcatg gtaaagaaac ccgtgaagat 1966321 ggttgtgttt atccttctcg ttgatatcaa aatgatacgt tctgccccgg aaactgaatg 1966381 taccgtcact tatgcggtta ggcgggaaca ggattggaat gccatacaat gttggtgtgt 1966441 cgtgaaaact ttctgctgtt tccggttcac gcaaaagctg gacatttgtt gttttgtcca 1966501 cgagagaaat gacgttgctc ccccactcag ggacaacaat catttctaga tgttcgttgc 1966561 ccgctttgat ggccggcgtt cccaaatacg tgattttctc aataaagttt gccatgttta 1966621 ctcaacctct ccttgattca ttgctagtat aagaattcaa tgtactgtac catatttcct 1966681 ccattttata ttttccccta tcaaataaaa aaacaccgtt caaacttatg aacggtgtga 1966741 ttcggaggct attggatgag acgtgtgatt tgtttctttt tccagacgaa ttgataatac 1966801 ccataaatca acagcaagct gacggcaaac gcagctggat aaccaaccca gacgccgagt 1966861 atttcaagct ttgtatagtg agaaaggacg aaagcgacag gcacctctac tccccagatt 1966921 gcaaaaatac tgatgacggt cggccataaa actgttccgc ttgcccgcat cgttgcagaa 1966981 ataatttggg catttccaaa cagcaaatag ctccacagtg taatcatcaa aagacggtgc 1967041 gcaatgtaaa gcgtctcttg ctcggttaaa aataacgata aaatctgatg tgaaaaaaca 1967101 tagatcagaa tgatcagtac gccgccaatg atataattca gccaaatccc aacgcgaatg 1967161 acctgcttta agcggtcaaa ctcgtttgct ccgatcgatt gcgcagcgaa aatagaaacc 1967221 gcaataccaa ggctgacggc cggcatctgt acatagctgg ccacctggtt gaccactccg 1967281 tatgcagctg ttgcattaga gccgtaatga ttgacgaatg aaataaccgc tatctctgat 1967341 aatgagacaa gaatcatatt gatgcttgct gggaccccaa gacgcagcag gagaaccagc 1967401 agttccttat ccattttcaa ataacgacgc actgttttat caaattgcag cgggtgtttt 1967461 cgctttcgta aatacaccat taacacgaga aaagtcgcaa tcgtggaaat gacagttgca 1967521 tatgccgagc cgtatatgcc cagtttcgga aaaccaaaca tgccaaggat taaaacaggc 1967581 aaaagcgcga tgttgatgac cgtgctcaca atcagcgtat aaaacggtgt cttggaatct 1967641 cctgttccgc gcaaaaaggt agtatatgca aaatataaaa acataaacgg catagcataa 1967701 aataaaatac gtgcatagtt agcgctgaca tgaatgacat tttcaggtgt tcccattaaa 1967761 cgaaggatat ccagggtgaa aatactgccg ataacggcta acacaacgcc taataaaaat 1967821 gtaaacgtga gtgtcgtccc gacaacagcc tttagccgtt cctcattttt cgctccgtaa 1967881 gcttgtccta tcagaatcga acttcctgaa ccgatcccaa tcgtaaatga gattaaaaga 1967941 aaaaataacg ggaaaaagga tgatacagct gccactgcat caacaccgag ccatctgcct 1968001 acagccatca tcccgactag ctggccgact gattgcagca cattgctcag cagaagcggc 1968061 actaaaaaga gtgacatcga ccgccaaact gatggtttgc ttttcttttg agttacaaga 1968121 ggttcttgtg atgtttccat attaaaggac tcctttattt gaaatcgttt ttaaacatgc 1968181 cctcattttt tgacaaaaac aggatatgta acatgttatt attcatcact gcacttatga 1968241 aacccttccc gattcttcta attttacaca tctttttagc ttatgaagaa taaactagca 1968301 agtaatggcg tattttttgt gagtaaaaga ataaaaaata atttatgcaa aagtattgta 1968361 atctatccgt aattattgta acatttgtaa cataagagaa agagattttg aaggagagag 1968421 cgataatgaa aaaatgtctt ctatttctaa caaccattgc acttattctg tcattaagca 1968481 caaatgcatt tgcgaaaaat acatcaggcg atttatcaca aaaacaagca ttacagttgg 1968541 cattatccgc tagagaacat ttttggaaca ccatgagcgg ccacaatccg aaggtgaaaa 1968601 aagcagtttg cccatcaggc acattcgagt atcaaaatct tcaatatgta tacatgtgca 1968661 gtgatctagg cactaaagca aaagcggtga attatttaac tcctattttt acaaaaacag 1968721 caatcgaaaa aggctttaaa gattatcatt tcactgtttc aaaaggaaaa cttgctgttc 1968781 caatcggtga cggagacaat cttttgaatt ggaaaaaatc aactgctaaa ctgatctcta 1968841 aaaaaggcag cacaatcaca tacgaattta ctgtccctac attagacgga tccccttctg 1968901 caaaacggaa agtgacattt gtgaaagaaa ataaaaaatg gaaagtcaat caatttgacg 1968961 cagttatata agaaaaacgc ccggtataag cgggcgtttt ttatttggtt tgcataaaga 1969021 aagacaacag gcgaaaagtg cctgttgtct ttttgtgaat ataacgctct aggagagatt 1969081 cgaactcccg acctgcagtt taggaaactg ctgcactatc cgctgtgcta ctagagcttt 1969141 tggtatttat atagtagctc tgatgatcaa tattttcaag cgatttgtat taaagccctc 1969201 caaaaacctt atatgcggct cttgtcgtat cttcatcaat accgatatac cgcattgtaa 1969261 ttgatggtga tgaatgattc agtattctct gcagctcggc gatgtctttc gttcgctgat 1969321 aaaaatgata gccaaacgtt ttccggagtg tatgcgtccc tatctcctca agtccgcacg 1969381 ctgcagcggc ctctcttaaa attctgtagg cctgaatgcg ggaaatcggc ttcctggtcc 1969441 gcactgattt aaaaagatat tcgttttcct tcatgtcttt cgtatactcg tatatttcct 1969501 gtttcagcga ttctaaaata agaatctttc ttttcttttt cgttttgctt tcagtcgccc 1969561 ataaatgatc tttattttga acgtccttca cttgcagcgg cagaatatca gaaatacgga 1969621 gcgcgctgtt gatgccgaaa ataaacagaa aataatcccg cttgtttttg ttaagcaaat 1969681 actgtttgac ttcttggatt ttctctagac tgcgaatcgg ctgtacaata tgcatcaaaa 1969741 aactccttaa aaaccgttat gtaacatttt gaggtctatg ttactattat agctgaaaaa 1969801 cgttgaatgt caaagtgcgg cggcgtttat gtaacataat atacatagtg ttacataagc 1969861 ttttaaaaaa gcttcttcca accttcaccc tataaaataa gctttaaagc ctcttataaa 1969921 gcttttaacc tcttggatac ttatccccct actaatcatc aaaaaacctc ttaaaatgaa 1969981 atctgacact cccaattttc tggagcttcc gcaaaaatat acaaaaaaag acacaatttc 1970041 aaattgtgtc ctaatcctca tcctttacat caatatcttc cgggatcggt tcatttaata 1970101 tttcctgcac aagtgctttg taattctcca gctgttcgag atgcgttttg aactgttcct 1970161 tataaatcaa aaattgctcc ccgtcatgaa cggctctgat tttcccttcg agcaccaagc 1970221 ttttaatata atcctctgaa agatttgtat attctgctgt ttcttcaatc gttaaataca 1970281 tatagcagtc ccttcttaat ccgtatgctg attctaatat agcacatggc tcatatcaat 1970341 ataatcaatt ctgcacagaa aaacggcatt atgcactata taatatacca tttgtcactt 1970401 gtgaaaacgc tgtaattttt ttacgctaag attgtaacaa tacagcttca tataggaggg 1970461 agaacatgaa aagaacgtgg aacgtctgtt taacagctct gcttagtgtt ctgttagtcg 1970521 ctggaagtgt cccttttcac gcggaagcta aaaaaccgcc caaaagctac gatgagtaca 1970581 aacaagtaga tgttggaaaa gacggcatgg ttgcgaccgc acatcctctt gcttctgaaa 1970641 tcggtgctga tgtgctgaaa aaaggaggaa atgctattga cgcagcggtt gccattcaat 1970701 ttgcactcaa tgtaacagag ccgatgatgt caggtattgg cggcggcggt tttatgatgg 1970761 tgtatgacgg aaaaacgaag gatacaacga taatcgacag ccgtgagcgt gctccagcag 1970821 gcgcaactcc tgatatgttt ctggacgaaa acggcaaagc aattcctttc tctgaacgtg 1970881 taacaaaagg tactgccgtt ggtgttccag gcactctgaa agggctggaa gaagccttgg 1970941 ataaatgggg aacccgttcg atgaagcaat taattacccc ttctattaaa ctcgctgaaa 1971001 aaggctttcc gattgattcg gtgttggcag aggccatttc tgattatcag gaaaagcttt 1971061 cacggactgc cgcaaaagat gtatttttac caaatggcga accgcttaaa gaaggagata 1971121 cccttattca aaaggatttg gctaaaacat ttaagcttat tcgctccaaa ggcactgacg 1971181 ctttttataa aggaaaattc gccaagacgc tttctgacac tgtccaggat ttcggcggat 1971241 caatgacaga aaaagattta gaaaattacg acattacaat tgatgaaccg atttggggag 1971301 attatcaagg ctatcaaatc gctactactc ctcctccaag ctccggcggt attttcttat 1971361 tgcaaatgct gaaaatcctt gatcatttta acctttcaca atacgatgtc cgctcatggg 1971421 aaaaatatca gctgcttgct gaaacgatgc atttgtcata tgccgaccgt gcgtcttacg 1971481 caggtgatcc cgaatttgta aatgttcctc tcaaaggcct gcttcacccc gattatatta 1971541 aagaacgcca gcaattaatc aacctagatc aagtgaataa aaaaccgaaa gccggtgacc 1971601 cttggaaata ccaagaagga tcagcaaact ataaacaagt tgaacagccg aaagacaaag 1971661 tagaaggcca aacaacccac tttacagttg ctgaccgttg gggaaatgtt gtttcttata 1971721 caacaacaat cgaacagcta ttcggaacgg gtattatggt ccctgattac ggtgttattt 1971781 taaacaatga attaacggat tttgatgcga taccaggcgg agctaacgaa gtacagccaa 1971841 acaaacggcc tttaagcagc atgaccccga cgattttatt taaggatgac aagcctgtcc 1971901 tcacggttgg atctcctggc ggggccacaa ttatttcatc cgttttgcaa accattctct 1971961 accacattga atatggtatg gaattaaaag cagctgttga agagccgaga atttacacaa 1972021 acagcatgag ctcttaccgt tacgaagacg gagttcctaa agatgtcctc agcaagctaa 1972081 acggcatggg ccacaaattc ggcacaagtc cggtggatat cggaaacgtg caaagtatat 1972141 cgatcgacca tgaaaacggc acctttaaag gtgtagctga ttcaagcaga aacggcgcgg 1972201 cgatcggcat taatttaaaa cgtaaataaa taaaaaactg tactcgcttc aaatgagtac 1972261 agttttttca tgcagatctt taaaataaaa actgacaaac gtctttattc tgctaatgca 1972321 cgtctatctt catcttttca tttcgtttat ctcatcaaga aatgtctgaa acgcactcgt 1972381 aataaaaaag tctttcctgt atataaagac gatctctaag tcttgatatg atggtggcag 1972441 ctgatgaatc catacatttg tacgatgctc ggagccgtca acagcggact ttgggagcag 1972501 cgccgtaccc atcccggcgg aaacaccttt tataatagcc tccaatgtgc caaactctat 1972561 gattttttga ttgtgtatgc ctgcttcctc tagtaatctt ttgaccctgt cacgatgaga 1972621 acagccagcc ccaaaaaaga gcatcggctg ctgaagcatg tcttctgccg tcccttctcg 1972681 tgatgaaatc aaaactaatt catcatggga gacatggagt tgtctaactg cagcgtgttc 1972741 aaccggccca tatacaaaag cgccatcaac tttatgatca agaacctgtt gaatcaaatg 1972801 atgcgtatca gctgtgttca ctgataaatc cacttcagga aaacgcctga ggaaggatgc 1972861 tgcatgctca ggcagatgcg ttaccgccat tgtttccagt gatccgatcc gcaaaggccc 1972921 ttttggttgc ctgctcattc gggtcgattt ttcagcttgg tctaacagcg ataatacttg 1972981 atctgcatat tgtaaaagat tttctcctgc agcagtcagc ttcattcccc gattcgttcg 1973041 atgaaaaagc ctgatattca aatcttcctc aaggttatgc actctggctg tcacattcga 1973101 ctgaacataa ttcagcattt gggctgcttt cgttatgctt ccttcgcgag caacagcctg 1973161 aaaaatcttt aaatctccgc tttccacgcg ctctcacctg cttgctatga tgaaaagtga 1973221 tattggctat catatttgtt cattttactc gaagaaaacc gctatgtaaa atatgtaaag 1973281 atatgaaaat acaattaatg aggaggcaga cagcatgaaa gctgtaattc acaacggaaa 1973341 agccggtctt ctggggttat cagttcagga cgttccatca acaaagcctg gatacggaga 1973401 ggtaaaggtt aaattaaaat ctgcaggcct gaatcatcgt gacttgtttc ttatgaaaaa 1973461 caaatctgaa caagatcctc acatgatact gggttctgac ggcgcgggta tcatcgaaga 1973521 gattggtgaa ggcgtgaaaa atgttactgt tcagacagaa gtagtcattt tcccgacatt 1973581 gaactgggat ttgacagaaa atgttccacc tgtacctgag attctgggag gtccttcgga 1973641 cggaacactt gctgaatatg tgatcattcc ttcacaaaat gcaatcaaaa aacctgctta 1973701 tttatcttgg gaagaagcgg gcgttttacc tttatccgct ttaactgcat atcgggctct 1973761 gtttacaaag gggcaattaa aaaaaggcga gcatctattg atacccggca tcggcagcgg 1973821 tgtagcaacc tacgctttat ttatggctaa ggcgattggg gcaacagtaa gcgtgacctc 1973881 ccgcagtgag gagaaaagaa aaaaggcgct gaaattaggt gctgattacg catttgacag 1973941 ctacagcaat tgggatgagc agttgcaggg aaaaaagata gatgttgttc ttgacagcat 1974001 aggacctgcc ctcttttcgg aatacttccg ccatgtaaaa ccaaatggcc gtattgtcag 1974061 ctttggggca agctcagggg ataatctcag ttttccggtg cgttctttat tctttcctca 1974121 ggtcaatgtt ttgggaacct cgatgggaag cggtgaggaa tttcaagcta tgctcgcttt 1974181 cattgacaaa cataagctgc ggcctgtaat tgaccggata tatcctttag aaaaagcatg 1974241 tgaagcatat aaaagaatgc aggaaggcag acagtttgga aacatcggga tcgtaatgga 1974301 ataaaaaaag aaaccggctg gcagccagac cggtttctct tatatgataa tcccctttat 1974361 ttacggaaga actgaactcc ccatcaaata tcgatccact tcacgcgcca cttcacggcc 1974421 ttcattaatc gcccatacga ttaagctttg ccctcttctt gcatcccctg cggcgaatac 1974481 accatcgata tttgtttgat aatccccata tgctgcactg attttgttat ttactgaatt 1974541 aacaccgaac tgtttcaaca gcggctgttc tgtgccttca aagccgatag cgataaagac 1974601 aagctgagca ggccatactt tttccgttcc aggcagctcg cggaactcgt attttccatg 1974661 ctcatttttc actttttcca tttggatggt atgaagctct ttcagctttc cgtttttatc 1974721 cgcgaccatt tttgtcgttt gaatggagta ttctctcgga tctcttccga attttgcttc 1974781 tgcttcctcg tatgcatatt caagcgtaaa gacgtgtggc tgttcaggcc acatattgtc 1974841 attcgtgcgg gctggcggaa gtttcgggtg tttgccgaat tggtgcacgc ttttggcttt 1974901 ttgacgcaga gcggtagcca cacagtcagc tcctgtatct ccgcctccga ttacgatgac 1974961 atctttccct ttggcatcaa tgaattgctt gtctttaaaa ttagaatcta aatagctttt 1975021 tgttgcaagt gtgaggtagt ccattgcgta atggactcct tttgagtcgc gtccttcgat 1975081 taagaggtcc cgctgttttt gagcgcctgt gcataagatc acagcatcaa attgctcctt 1975141 tagctcatca gctgtaatgt caacaccgat ttctgtgttc gtgacaaaat caattccctc 1975201 ttgcgtcagc aatttaattc ggcgttctac aatgcccttc tcaagcttca tgtttggaat 1975261 gccgtatgtt aaaaggccgc ccgctctgtc tgctcgttca aaaacagtga cggaatgtcc 1975321 cgcttgattc agctggtcag cactcgccag tccggctggg cctgacccga cgatggccac 1975381 ttttttgcct gttcgttttt ttggaattct aggttgaatc cagccgttct caaatccttt 1975441 atcgataatg gtccgctcga tgtttttaat tgatacggcc ggatctgaaa tcgctaaagt 1975501 gcatgatcct tcacaaggag cggggcatac ccgccctgtg aattcaggaa agttgtttgt 1975561 tttcaacaga cgttccaatg cttccttcca tctgccccgg tagacaagat cattccattc 1975621 aggaattaag ttgtaaatcg gacagccgga tgtaaatccg ttaatgtccg caccgatctg 1975681 gcaaaacggt gtaccgcaat ccatacaccg cgccccttgc cgtttcgatg cttcttctga 1975741 aaaaggagca gaatattctt tccaatcctt taagcgagtg agagggtccc gctccgcagg 1975801 tttttctcgt ttgatctcca taaatccagt tggtttcccc atgttcctct ccccttcctt 1975861 actgtactac cgcttgtttt tgtcccgatg ctgctgtatt ctgctttggc ttcgtgttgg 1975921 cctcaaaagc gaacatgatg gcttcttcat ctgataaacc tgcagctttt tgctcttcga 1975981 tgcttgcgag catttgttta tagtttttcg gaatgacttt gacgaatttt ttcacactgt 1976041 cttcccattg atctagcaga tcttctgctt tttggctgtt tgtatacgca gtatgtcttt 1976101 caagcattgc tttgatttgc tggatttctt tctcatcctc taatgattca aataaaatca 1976161 tctcaaggtt gcatttgcgt ttaaacgctt tgacatcttc ggtcagtaca taagcgattc 1976221 cgccggacat acctgccgca aagtttttgc ctacatcacc gagaacgaca acgctgccgc 1976281 cagtcatgta ttcacagccg tggtcgccga tgccttctac aactacgttc acaccgctgt 1976341 ttcgaacggc aaagcgttca ccagcacgcc cgttaatata tgcttctccg cttgtcgcac 1976401 cgtaaaaagc cacgttgccg ataatgacat tgtcatccga agcagagttg aatccttctg 1976461 atgacttgac gatgattttt ccgccagaaa gcccttttcc gacgtaatca tttgagtctc 1976521 cgtccaaata aagcgtcatc cctttaggaa cgaaagctcc aaagctttgg ccggctgatc 1976581 cggtaaagtg cagcttgatt gtatcttcag gaagaccttc ttctccgtaa cgctttgaga 1976641 tttcactgcc ggttatcgtt ccggctacac gatttgtatt attgatttca atcgaaatat 1976701 cagcttcttt tccagattcg atggcttctt gtacggccgg gagaattgtt gtaatatcaa 1976761 gtgattgatc aattttatga ttttgcggcg attggaacgt ccgcacccct tcaggctgat 1976821 aaagaagggt agacaaatca agctggcttg ctttccagtg ctcctttgcc cgttcacttg 1976881 catgaagtac atcagtgcgg ccgatcattt catcaaatgt cttgaagcct aacgcagcca 1976941 tgtactcacg aacttcttcg gcaatgaaca gcatatagtt cacaatatgg tcaggatctc 1977001 ccatgaactt tttgcgaagc tctggatttt gtgtcgctac accgacaggg catgtatcca 1977061 aatggcaggc acgcatcatg acacagccga gtacaactaa cggagccgtt gcgaaaccaa 1977121 attcttcggc gccgagcaag gcagccatca caacgtcgcg gcccgtcatg agctttccat 1977181 ctgtttctaa tacaacacgg tcacgaagtc cgttcagcat tagtgtttga tgtgcttctg 1977241 caaggccaag ctcccacgga agccctgtat gtttaatact ggttttcgga gaagcgcctg 1977301 tacctccgtc atagccgctg atcacaatga catctgcagt cgctttggca acacctgcag 1977361 cgattgttcc tacacctgct tttgacacca gctttacgct gattcttgcg tcacggttgg 1977421 catttttcaa atcgtggatc agctgggcta aatcctcaat cgaataaatg tcatggtgtg 1977481 gcggaggtga gattaatccg acacctggcg ttgacccacg gacatcggca acccatggat 1977541 ataccttgtt gccaggaagc tgcccgcctt cacccggctt agcaccttga gccattttaa 1977601 tctgcagctc atcagcattg acgaggtaat ggcttttgac accaaaccgt ccggatgcaa 1977661 tttgtttgat cgcacttctt ctatcatcgc cgttctcatc tggaacaaag cgtttgggat 1977721 cttctccgcc ttcaccgctg ttgctttttc ctccaagacg gttcattgcg attgctaaag 1977781 cttcgtgcgc ttccttactc aaggacccga atgacatcgc acccgtttta aaacgtttga 1977841 caatcgattc agcggattca acctcctcca acttcaaagg cttgcggttt ccgtcaaatg 1977901 cgaacaagtt ccgcaaaaat ccgatgcgtt cttcatcagc cgcttttgta tactgtttaa 1977961 acagattgta atcatttctg cggcacgccc attgcaaagt atgaatcgtt ttcggattaa 1978021 acgcatgatg ctctccgcca tttctccatt ggaagtcact tcccggttca agcgttttgc 1978081 tgtaatcatc ctgatacgct tcccggtggc ggcgctgtgc ctcttctgca attgtttgta 1978141 aatcgatgcc gcctagctgt gatgcagtac ctgagaaata gcggtcgatc acatcgcggc 1978201 tgattcctac cgcctcaaag atttgtgcgc ctctgtagct ttgcacagtt gaaattccca 1978261 tcttggacat cacttttacg acgccctcag taatgctttt tccatatttg ctaaccgctt 1978321 cttcatagct gatatccaaa cggccttcat caatttcctg cttgtaggtc gcataagcga 1978381 gataagggtt aatcgcatct gcgccataac cgattaacgc tgcaaagtga tgcacttcac 1978441 gtgcttctcc cgattccaca ataatgctga ccttcgtacg cagccctttg cggattaagt 1978501 gctggtgcag tgcgcttact gccagaagcg gcggaattgg tgtcagtcgt tcgttcatct 1978561 ttttgtctga taaaattaac aaacttacgc cttggctgat ggctttctct gcctgtgtga 1978621 acatgtcctt taaaccgcgt tcaagatcct ctgaaaacag cacatcaatt ttttggcttt 1978681 ttaaatcagg atgaacaatc gttttcaatg cgtaaaactg ttcattggat aaaacaggtg 1978741 tatacagttt aatccggcga acatttcgtt cacttggatg aagaagatcg ccttccgcac 1978801 cgagccaagt catcgttgaa gtgacaagct gctcacgaat cgcgtcgatt ggcgggttcg 1978861 ttacttgtgc aaacagctgt ttaaagtagt taaacagcga ttgcgctcgg tcagaaagta 1978921 cagcaagcgg agcgtcattc cccattgaac caaggggatc tttgccttct ttaataacag 1978981 gaattagata cttttggata tcctcatatg tgtatccgaa tgccttctgg cgagtaagaa 1979041 gatcactaaa ttgttcttct tctcttgact ccggatcagg atttacttgt acaagctctt 1979101 cttcaagcca tttttggtac ggatactcag ttgcaatttg tgttttgact tcctcatcgg 1979161 agataatacg gccttcttcc aggtcgatta aaagcatttt cccaggctca aggcggtttt 1979221 tatataaaac gttctcctgt tcaacttcaa taacgcctac ttcagatgag aaaataatat 1979281 aatcatcttt tgtgacataa taacgggccg gacggagacc gttccggtca aggatcgccc 1979341 cgatttgttt accgtcagta aatgaaatag ctgtcggtcc gtcccaaggc tccatcaggg 1979401 agctatggta ctcgtagaac gccctttttt ccttggacat atgcgtattt tccgtccaag 1979461 gctctggaat gagcatcatt gccgtatgtg ccggtttgcg tccagccatc acaaaaaact 1979521 caaatgcgtt atccaaaatg gaagagtcac tgccatcagc attgagaatc ggcaaaatct 1979581 tgtttaagtc ctcaccgaag ctttcagaaa caaattgctg ctcacgtgct ctcatccagt 1979641 tgatatttcc gcgaagggtg ttaatttcac cgttgtgaac caaatagcgg ttaggatgcg 1979701 ctctttccca tgtagggaat gtattggtac tgaagcgtga atgaacaagc gcaaaagcag 1979761 aaacgaatgc ttcgtcttgc agatcagaat aaaatgcatc aacctgttca ggtgttaaaa 1979821 ggcctttgta aacaatggtc tggcttgaaa gactggcaaa ataaaaatca agaccttccg 1979881 ttactcccca attttcagcc tgtttacgaa tgacatacaa ttttcgttca aaagataaat 1979941 tgtcctttag atcagaactt gcgccgataa atacctgacg gacaaacgga cagctttttt 1980001 gcgccactgt tccgattttt ccgacattta caggtacagt tctccatcca agaacgactt 1980061 ggccttcttg ttcaattagt gcattgattt gcttttcaat tttttttctt tcatcttcct 1980121 tctgtgagaa aaagaccatt cctaccccgt aacgttcttt ttctggcaga ttgatgtttt 1980181 tgcactcttt tctaaagaaa gcatcaggga tttgaaccag taagccggct ccgtctcctg 1980241 tatccggatc actgccttgc cctcctctat ggtctagctg gcaaagcatc ttaagtcctt 1980301 gtttgacaat gtcgtgagtc tgcttgccct ttaagtgtgc atataggccg attccgcatg 1980361 catcatgttc aaattcagga cggtagagac cttgagcttt tggcatttga ttgtacgtca 1980421 taattcctct cccccgatca atttccgata ataccggtca taaaatctaa caactctata 1980481 atcattgtag gttttcaaaa cgatataaac aatatataat ttagatcaaa agaatctcaa 1980541 aatgagatag atggatgtga gacaaacatg gagctgcgcc aactgcgtta ttttatggag 1980601 gtggctgaaa gagaacacgt ttcagaagcc gctgatcatt tgcatgtggc ccaatcagca 1980661 atcagcagac aaattgccaa tcttgaagaa gaattaaatg tgaccttatt tgagcgtgaa 1980721 gggagaaata tcaaactcac gccaatcgga aaagaatttt taattcatgt gaaaacggcg 1980781 atgaaagcca ttgattatgc gaaagagcaa attgatgagt atcttgaccc gcatcgcgga 1980841 acggtaaaga tcggctttcc tacaagcctc gccagccagc ttttgccgac tgtcatttca 1980901 gcgtttaaag aagaatatcc gcacgtcgaa tttttgctgc gccaaggctc ctataagttt 1980961 ctgattgaag ctgtcagaaa ccgcgatatt gatctggcct tattagggcc ggtgccgacg 1981021 aatttctctg acataacggg aaaaatatta tttactgaaa aaatttacgc gcttgttcca 1981081 ttaaatcatc cgcttgctaa acaaaaaacg gttcatttaa tcgatttgcg caacgaccaa 1981141 tttgtattgt tcccggaagg atttgtactt agagagatgg caatcgatac ttgcaaacaa 1981201 gcaggctttg ctcctctcgt ttccacggag ggtgaggatt tggatgcgat caaagggtta 1981261 gtgtccgcag gaatgggcgt tacccttctg cctgaaagta cttttgctga aacaacacct 1981321 cgttttactg tgaaaattcc aattgagttc cctcaagtaa aacggactgt cggaatcatt 1981381 aaaccgaaaa atagagagct tgcgccttcc gcgaatgatt tttatgagtt tgtcattcaa 1981441 tttttctcta agctggagca gtatcaataa aaaaaatgaa cccgagcttc tatatagaag 1981501 cttcgggttt ttttctgcaa attaatttac aggtaaagaa aaatccacat ggcaaacaaa 1981561 tgcttcttga tcaattagag ctctatttgt cagttccttt ttcttttccg gttcttgaag 1981621 ctgtacagaa gagtaattga cgattccaag gccgatttcc gtcccttttg aatccatcag 1981681 ccgaacaact gaaccgcttt tgaatttccc tttaatcttc tgtacaccgt ctaggtataa 1981741 actcgattgt ccgtttgtta tttttcgtga acaatcatct gataaaatca tttcaccttc 1981801 cggaccggaa ttaaaagcga tccattgctc cttttgattc aacggaagcg ttccttctgc 1981861 ttcaaaatag gtgccttccg cctgttcatg aacggcgtgg tataaaatat cgccagcatc 1981921 tgcctgacct aggaaacctt taatgccaga cgccattacg attttaaacg catcaagctt 1981981 agagcgcatg ccgccggtgc caacgatgct tccagtgtca cctgcgcatg cttcgatgtc 1982041 aggtgttatt tcactcaccc gctgtatctt tttcgcttct ggatttgtgc gcggattgcc 1982101 gtcatataat ccgtctatat ctgataaaat cacaagcata tctgcatcaa tcaatcctgc 1982161 gacttttgct gcgagcgtat cattgtcgcc aaacttgagc cgattgacgg taactgtgtc 1982221 attttcgttt atgatcggga tgatgccgcg ctcgagcagt acattcattg tattcctgac 1982281 attgttgtat cgatattcat cagaaaaatc gcttctcgta attaaaattt gggatgcgac 1982341 atagccgtgt gccaaaaaca gctttgaata agcctccatt agcaatccct ggccgattga 1982401 agctgatgct tgtttttctg gaagcttctc gggcctttgg ataaatccga gcttccgata 1982461 tcccgccgcc actgcgcctg aggaaaccaa aatcacttca taaccggcgt ctttgagttt 1982521 gacgacctgg tcgaccaacg cttctaattt tcgaatgctg atttctccat gaaggcttgt 1982581 taatgaactg cttccaatct tcacaacgac tcttttcatg cttgtatcag gcgtcacttt 1982641 atcactcctg atagcggcgc tgcagttttt tcgatatctt cgctgatttc ctttgaacgc 1982701 ttagccgcat gctttattgc ttgagaaatc gcttctccgc cgccgctctt tttcaaggct 1982761 tgcagccccg ctgctgtcgt tccgttcggt gacgtgatat tatctcttaa gatctcagga 1982821 tgttctcctg tttccatgag catttttgcg gcacctaaaa gtgtctgtgc gccgatgctt 1982881 cgagataact gtttatcgag gcccgcttcc tcgcctgtct tttcaatgaa ttccattaaa 1982941 taataaaaat acgcgggtcc gctgcctgca attccggtga atatatccat ttgattttct 1983001 tggattgtat agacttcgcc catgcatccg agcaatgctt cggccagctt cttcaggtct 1983061 tccgacacat atttgccaag ggcaatagct gttgcagaag cgccaatcat actggaagtg 1983121 ttgggcatca ctctgacaac cggctgttca ttaagcaatg attgttcaat aaaagaggta 1983181 gttatgccgg caaggaccga caatattaat tgatggggtt gaatacgtga ttttagtgat 1983241 gacagagcgt tttcggcgtc ttttggcttc attgccaaaa tgagcacatc catgtcttca 1983301 atacatagtt ggttcggcaa ggcgccttta atgccatatt gaagttcaag ttcagttaat 1983361 cgctctgtat tgctgcggtt tgtaacgcag atgttttgtt tcgggatttt gttggctcga 1983421 acgatacctg atatcattcc ttccgccata gatcctgctc ctataaaggc tactttcttt 1983481 tgatcaaaga tcggtaacat ctcctttgtt cgcttttttg ttcgcatttt cacacgttta 1983541 aaatgttacc acgtgaggaa atgatgtcaa gtttgaaggc cattattgat ttgtattgtt 1983601 tcttttcgac aaatatgtat aatgaaaagc agaaaacacc cggttcacac tgctgcgccg 1983661 ggtgtttgtt tctattaaaa attatctgag agagcttttt caatcagttt tttacagcga 1983721 tccagctcta ccttcagctg ttttttatat agcttggcag cttcgtaatc tttaaattga 1983781 tagaggacga cttcctggag cttagcccct tcttttttta ctttaatttg ttttagtatc 1983841 ccgtcatcaa gaagctcatg caaagaccgg tatacttctg tatgatttgg tttaaaacca 1983901 atctctttaa attcagaccg aagtacttca agcagcttta acccatagag tctctcttgc 1983961 tctgtcatcg ttatcatata aagcttcaaa aatgcgcgct gtttcactaa aaagcctgtt 1984021 gaactccttt tttcttcttt catcatatgc actccttctt ctgtcactga caacactatg 1984081 tactaaatat tcaattttct tttattgttt tccttcttta tattaaagac tgatagtcca 1984141 gttatttcat gtttactgat tataggtgta gcggaaaaaa taaatttcga ctgaacattt 1984201 ggtacatagt tttcttagtt ctattatagc ctgcatttac tgctatcttc aatttaaacg 1984261 attgccaggg tttacatatc tcattttacc ggtacggatt tcattcaaat aaaaaaacct 1984321 gtcgaaagac aggttttcat ttttaaggat ttgttgacca taatcccgct gttttgatga 1984381 aaatacgagg atctaatttc agttgtgcca ccatgtactc agcaagatcc tcaggctgca 1984441 taactttttc aggattaccg tctgttaagt tcaattcgat agacatatca ctagcgacag 1984501 tgctcggcgt taacgcgctg actctgatat tatgttttct cacttcttgc ataagagact 1984561 ctgttaaccc gagaacggca aatttagaag cgctgtaagc acttgttaca gcagctcctc 1984621 tttggcccgc tgtagatgaa atattaatga tgtctccggc tttgcgttcg atcatttccg 1984681 gaagcaccgc gcgagtgaca tggtacacac ccattaggtt gacttgaata atattttccc 1984741 actcatcagc tgacagatct aagaaaccgc caaatttgct gatgccggca ttattaatga 1984801 ggatatcgat atcaccgagc tgttccttca cttgagctac agcttggtta acctgatcgg 1984861 catcttttac atctgcagca gcaaatgcag cttttacacc aagcgctttg acttcttcag 1984921 ccactttttc tacattagcg gaagtccggc caattaaccc gatattcacg ccttctttgg 1984981 caagcgccag agcagtagcg cggccaattc ctctgcctcc gcctgtgatt agtgcagttt 1985041 tatgttgtaa actttgcaat tgaagcaccc tttctttgtt tacatatgta cgatatcaca 1985101 ttataagtac aatacatcca atacgcaaat caaacgaact gtgtaaatat catttcttct 1985161 gattaaaaaa acggatacag ggtaatgaca taagaaaagg agtgaacata tgattatagt 1985221 ttatatcagt cttgcagtat tagcagtttc tattatcttc ttaggagtta ccgtgatcca 1985281 aaacaagaaa aaaatagacc ccgcactaaa ggagctttcc tctgttacgc aggctatgca 1985341 aaaacaaatc gaaggattaa aaacagaaac agagctgctg acgcaaaaac aaaagaagat 1985401 tcagcaggat gtccaaataa aaaaatacac gcttcagcag accgcagctg aagtgaaaga 1985461 agttccccaa gcagtcaaag aggtgtggca ggcaggacat tttaatagca gataaggatg 1985521 aatgagatcc cgttgttacg atcagaatgg acaaatggga tctcattttt cgaggaggct 1985581 tacacatgat tataaaccgc agctgcttaa aagagttcgc agaaaaagta cattttcttc 1985641 cctcttcact tacaaagtcc gatttactta ctgatccatt tcgtctccat caagaaaacg 1985701 aacttggcat ctactattca cctcataatg aatttatcaa tcgggatgcc tcgcttgtga 1985761 ttgccgggat cacgcctggt ttttcccaga tgaagacagc gtacgaaaca gccgccgaaa 1985821 gcctgctgca aggcgggact cttgagcaaa tggcagtaga cacaaaaata gcagcgggtt 1985881 tctccggatc gatgagacat aaccttatta ccatgctgga tttatgcggg ctgccgcaag 1985941 cttttggcat tcaaagcgcc gcaaagcttt ttggagaatt acggcatatg ctccatacaa 1986001 cttccgttat taaatatcct gtctttatcc agcaaaaaaa ctataccgga tacaaaccgg 1986061 ctatcactca ttctcctatc ctaagcactt atgcttttgg gcacttccct gcagagctta 1986121 accatgtgac gggaccagct cttctcattc cgttaggaaa agcggccgaa acagtgtgtg 1986181 aaacattgat cagacagcac agcctccaga atttgatttg ccttaacggc tttccccatc 1986241 catcaggcgc gaacggccat cgtttgaaac aattcagcaa aaacaaagag caactagaaa 1986301 gacaaattcg ttcctttgct gcattggttg atttcgctat agaaaagagg aaataaaagg 1986361 gatatgataa acaaaaacac aaacgtgggg agtggttgaa tgtttcctat attagaaacg 1986421 gatcggctta tacttaggca aatcacagat caggatgcgg aagccatttt tgcttgtttc 1986481 tcaaacgatg aggtgacacg ctattatggg cttgaaaaca tggaatctat agaacaggcc 1986541 atttcaatga ttcaaacgtt tgctgccctc tatcaagaaa aacgcggtat acggtgggga 1986601 attgaaagac gggacactaa agaactgatc ggaacaattg gctttcacgc tctggcccaa 1986661 aagcataggc gcgcggaaat cggttatgaa atcatcccgg agcattggcg aaacggattt 1986721 gcatcagaag tcatttcaaa ggtcgtatct tacggatttt ctgcccttgg actgtcgcgt 1986781 attggcgcag ttgtatttac cgataatgaa gcatcaaatc gtctgcttct aaaaatgggg 1986841 tttcaaaaag aaggcgtttt aagacagtac atgtatcaaa atgggactcc atatgataca 1986901 aatgtgtact ctattgtgaa accaagagaa tgacggtatt ctcttggtct gtgccacatc 1986961 ccttttcctt taaaaagata aaaagcgccc ctcaaacagg gcgctttcta attaagatgc 1987021 atattgagga gatgtttcct ccttaactgc tttttcctca ggtatatgaa tacattttgt 1987081 caagaccgca cttgcaaggt aaagggccgc aaagatccag acgacacctt gcgcgccgac 1987141 gagaccgatg aacagccaag cgagtgcagg gccgacaaac gctgataaac ctgcagctaa 1987201 attcaataca gacatggctg cccctttatc ttttcctgcc accgtcggca caattgcacc 1987261 aatcggcaca tagcctgcca gcaaaccgcc ccaaataaag ccgatcacgc tgacaaccgc 1987321 taaacttccg ccggagaaaa caggtgcgta gtataataag acggtgaaaa tgccgcagcc 1987381 gactccgccg aaccaaataa cagtattttt ccagccgaat ttatcgccga caataccgaa 1987441 gataaggtta aacacaatgt tccccaggaa aatcgttccc caaatttgca gccacacatt 1987501 ggttgaaatt ccatgctggg ccatgtgcat cggcaaaaag actggaaaac catatgtacc 1987561 aatgctgttg atgattctga tgattccgcc tgtaagcacg cgcggatttg taaatagaat 1987621 cgtaacccct tttaaaagct cctcggctgt ttctgatctt tttcttttct tcttttcaaa 1987681 acggtcttta ttgataaaca atgcaaagaa tgcaccgaga catacccaga aaatagagct 1987741 ccaaagcgta ttcaaataac cgaacgcttt gatcgcgtag cttgagtacc aagcgccgaa 1987801 cacaaacatg ccgaggcaat atgcaatcca aaaccagccg acagcagtgc tcagtttgct 1987861 ttgcggtgtt ctgtaaatga cccatgtcaa gaaagaataa gcaaaaagcg ggtaacctaa 1987921 cccttttacg aagtaagtca catacatcac tggcaggttc agctgttcaa atccaaatac 1987981 gataaaagca gctgtaccga tcacataaaa caacagcccc ataaacatcg ttcgttttgc 1988041 gccaaatgct tcgagacata cacccgaaaa ccaggaagct atggcaagcg caattccgta 1988101 tatactaaaa atggaagcgg actgctgaac ggtgagcccg ttttcgatca aaaaaggact 1988161 gagccagcct tgttcaaggc catctcccat cataaacaaa acaaccccta aaaatcccca 1988221 ggcaagccgc ttcggtattc ctattttatc caacatatct gtctcctcct tagatgctat 1988281 tattcattac cgtattacct tattaaagtt gaaaattaaa tgattcctca aaacagcaga 1988341 aattccgtct taaattaata ctttgctttc tgatcctgaa aaaaagcgct gtgtttgctt 1988401 ccattcctca tataaagcca attctatctg acagtccttc ggttcgatca cccggacatt 1988461 tgctgacatc tcctccgtta attgaaaggt ttcattgcaa atgactgcag caccgacgac 1988521 agatgcctga tgatatccct cttggacata gacctttttt tgaagaagat ccgcgatata 1988581 ttgagtgagc gctttgcttt ggaatccccc tccgcacacc caaacataat cacgttcaaa 1988641 cggagtaacc tctgttaaaa tgtcaaagtt ccatttgatt gaaaatgcga tctcttctag 1988701 cgctgcacgt acaaaatgtg ccctctttaa atgtgctgac agcggggcat caaaaagaaa 1988761 accgcctctc gttaacgcat tcttttcagc cgataaataa gagccgagag ccgctacaca 1988821 tgcatggtct tcttttgcaa gtgcagaaat ctcctcctcc attacttcgt acgtttcatt 1988881 cggataaaaa atctgtttta atttttgata attcaagccg gtaattcccg gattcgtttc 1988941 cacaagccaa tgcccttgat ccgtatgaca gttcaaccag gctttatgtt ttgtgtcgcc 1989001 atgatcctca gtaattttgg ttattggcgt tgttgtccct gatacaatga caatgtcctc 1989061 aagtccagct ccggtgcttt tgacagccag ctgtgtatcc ccgccccctg ctataacctt 1989121 agcatttatt gaaaggccta attcggatgc atattcattt gctatcgttc caattgctgt 1989181 tcccgctctt acaagaggcg gaaggataga tggagaaaag ccgaaaatgt cgcacatctc 1989241 ttctgaccaa gtgttttgct tcacatcaaa tagcagggtt tctgttgcct gtgatggttc 1989301 atatgttaat attccgctca gttggtacgt cacccaatca ctgatgcttg taaagcttgc 1989361 agtcttttcc cataaagagg gctggcgctg ttttaatcca taaagcttga gcgcagaaaa 1989421 aagtgcagtt ggcaggcggc ctgtgctgct gtatatctct tcccaatcgg gaatgcccgc 1989481 ctcccactct cggccgcgat tatcgatgtt cggcagcccg agaaaaggat tgccgttttg 1989541 atcaatcaaa acaatcccct gtctttggct cgtcgatgtc aaaccaatga tgtcaatatc 1989601 acacgaacgg gatagcgcac gttttgccaa attcatcacc tgcttccaca gcacctgagg 1989661 agaaaaataa cggctgtccg ggtaaagcgt ctctgtggaa tactcgatgt cctcccgttc 1989721 aactgttaga acactgccag ttacactcac gaccgctacc ctcgcattgc ctgtgccaat 1989781 atcaaaaacg agatagcctt tttgtttttt cattctgtta gcctcctttc ttatccccct 1989841 gttttcagtg cgtccttgtt atacattgtc tgaatattaa gagttttttc acccttccac 1989901 tttttgaggg ctttattcag tatcgtcacg tgatgatcct ccacttcaaa tgttgctcca 1989961 gcgagatgcg gtgttgccag aacattaggc aatgaaatca attcataatc tgattcctct 1990021 ggaggttcat gataaaaaac gtctagtatc gcaccgctga ttttatgttc ttttaataca 1990081 aataaaagat cttcacggtt tacaacaact gctcttgaag tattaacgaa aatcgcactc 1990141 tctttcatca gatcaaaata ttgccgatct atcagtccga gtgtttcctc agtgcgaggc 1990201 agatggacag aaacgatatc gctgtctgaa aacaccgttt taagagatgc tttttcatac 1990261 aacggatgat cgtcttgaat gtatggatcg taatatttta tcttacagtc aaacgcagtc 1990321 agcagttttg caatcctttg cccgactgcg ccgaacccaa tcatgccaac cgtttttcct 1990381 gttagctcat ttcctttaaa tttgacataa gcctgcaggt aatcactgtc ccactctcca 1990441 tccttcagcc actgattcga ggcgctggta tggcgcagaa aggaaatcac atttccaata 1990501 aacatttcgg caacggcttg tgcattccgc cctggtgtat aaaaaacagg tatgcccctt 1990561 tttgaggcag ctgccacatc cacatttgag ggcattcccc tgcaaacacc gacaaatgaa 1990621 agttcgggaa cagaagcaaa tacgctgtct gttacctgat caagttcagt aatcaagcct 1990681 gtcgcatttg ttgcttttag cagctgaatg agttcatcct cccgatatgc cctaccttgt 1990741 tccttccaag attgataagc aactgagcca aacaagtttt caagctcttt tcgtccttct 1990801 tcgttgtacg gtgctgtaac caaaaccgtc atgctgcaaa acatcctttt catcgtattt 1990861 ttcataaaaa aaatctcttt ccgaagatgg aaagagattc atatataggc gcgctctgtt 1990921 acaggcagac gccggtataa accttgcttt cctatctttc aagctagcgc ttgctggaat 1990981 tggcacaata atgttgccga ggtttcatag ggccagtccc tccacctctc tggatagaaa 1991041 atattgagta tgtaattttc agaatgaaga atacgtttat cataaagaag actcagattg 1991101 atgtcaatct ctttttttca gaattgacgt tatcatcgga aatgttataa ttcttacaaa 1991161 atatctaact agagagagga actgggccat gagatctttt gccacacaac aaaacggcat 1991221 tttcaaatcc gtttgctcgc tggactgccc ggatcagtgc ggattgttaa tacataaaaa 1991281 agacgggaaa atcgtaaaag tgcaaggaga ccctgatcat cctgtcacag ctggaaacat 1991341 atgcaacaaa gtccggaata tgacggagcg catctatgat gaaaagcggc tgactacacc 1991401 gctcaaacga acaggtgcga aaggccaagc gatatttgaa ccgatttcct ggaaagaggc 1991461 aatcgatacg atcacctccc gctggaaaca gctgattgat gaagagggag ctgaaagcat 1991521 acttccttac agcttttacg gaaatatggg gaaattgaca gctgaaggaa tggaccgccg 1991581 ctttttttac cgcatggggt caagccagct tgaacggacg atttgcagca aagcgggatc 1991641 tgaaggctat aaatatacaa tgggcataag cgcgggaatc gatcctgagg aaaccgttca 1991701 tacaaaacta tttatttttt ggggaatcaa cgcggtcagc acaaatatgc accaaattac 1991761 gatcgcccaa aaagcgcgaa aaaaaggtgc caaaattgtc gtgatcgatg tgcataaaaa 1991821 tcaaacagga cgtcttgcag attggtttat cccaataaaa ccgggaaccg acagtgcact 1991881 tgctcttggc atcatgcaca ttttatttaa agaaaacctt catgatgaag catttctgtc 1991941 cgagtacacg gttggctatg aagagctccg tgaacacgtg aaacaatatg atcctgaaaa 1992001 ggtatcgacg atcaccggtg tcagtaccga agatatttac cgactggcaa aaatgtacgg 1992061 ggaaacctcc ccttctttta tcagaatcgg aaacggaccc cagcatcacg ataacggggg 1992121 gatgattgta aggacgattg cctgtcttcc ggcgatcacc ggccaatggc tgcacacagg 1992181 gggcggcgca attaagcata acagcggaat tttagaatat aacacaaatg ccttgcagcg 1992241 gcccgactta ttgaaagggc gcaccccgag gtcgtttaat atgaatcagc ttggcagggt 1992301 gcttttggaa acagacccgc cgattcgctc tctatttatt tacggaacga accctgccgt 1992361 cgtcgcgccc gaagcaaaca aagtcagaca gggcttgctg cgggaagact tgtttactgt 1992421 ggttcatgat ttgtttttaa cggaaacggc tgcatatgcg gacattgtac tgcctgcaac 1992481 atccgctttt gaaaatactg atttttacac ctcctactgg caccattaca ttcagcttca 1992541 gcagccggtg attgagagat atggggaaag caagtctaac actgaggttt tccgattact 1992601 ggctgaagcc atgggattca cagaccagga gcttaaagat tcagatgaag tattaatccg 1992661 ccaggcgctt gaccatccag ataatccgca tttggcagag attgattacg attcacttac 1992721 taagcattca tttatgaaag cgaaacgtga aaagccgctg tttccgggcg aacttccaac 1992781 gccaagcgga aaaatagaat tatattcaga aaaaatgaaa caagacggct tccctgcttt 1992841 accgacatat acacctcttg taaccgataa tgaacatccg tttatgtatg ttccggggcc 1992901 aaaccataat ttcttaaact caacattttc caataatgaa aaacacatca agcttgaaaa 1992961 gacgccaaag ctctttatca acacaaaaga tgctgaaaaa cacggaatcg ttgatggggc 1993021 acctgtacga atttggaaca gccggggaga atgcgagctg accgctgcag ttggagaaca 1993081 agtgctgcca ggtgtcgttg tcagccaagg attatgggcg gatgaacaag gaaaaaaaca 1993141 gcttgtaaac gcgctaaccc cagatcgctt gtccgatatg ggcggcggcg ccaccttttt 1993201 ttcaggccgt gtacagattg aaaaggtttg aaaaataatg aaacccggag tatgccaagc 1993261 ccgtataaca taacatcgac ataatggagg catacacatg gacgtttttt taggaattgg 1993321 tattgctttg gctggatatt ttatcggtga aggcttaaag cagaggaacc aaaccaaagg 1993381 taatgaacaa aatgatatct tcctaataaa agaacgggat atttactttt acattggact 1993441 ttttttagga ataacaacga ctgaagcaaa acagttagct ggagacatgg cagacctgcc 1993501 ttacatcgaa ataaacggaa aaaaatatgt ccagaaacat atgttaaaag attggacatt 1993561 cacattagtt gaaaaacatc agggtgaata aaacaaatct gaggagagcg agattcattg 1993621 tcacgctctc ctctgtttag ctgtatggat cctgccacca aaactttgtg ctataagcgc 1993681 tgataaaacg ataaaccacc atctatgttc tttcctcaaa caactcaaga tgcccgttcc 1993741 acaacaatag tttttatatt cctttgatga cgtgatgttc ttgatgaacg tatgtatcgt 1993801 aaaacactta gaaaacctat tcggtttgaa tgtgtgctct cattatgccc ccatactgcg 1993861 cctttatccg cggaggattt ttttaaaaaa atatgaaacc taaagctttt agatcctgaa 1993921 tttttattga acctccatat ttctccgatt ggtaaaaatt agcctataca ccggaagctg 1993981 tacgtttata aaggatcaga gaatcccata accagtaaat cactgcagcc gcaatactta 1994041 acatataata aaagtacgat tgcaatgtcc atgctattga cgcaggttca ttgataacaa 1994101 aaaacaggaa agctgcgata aaagcaacca cactgtaaat caataggtac atgacattga 1994161 aagttctcgc ttttttctgc aacttcattt ggagcggaac agcaaaaagg ccatacacca 1994221 caaaaccgta taataaagca attgctgccg taaacaatgc aattatcata tcgccataca 1994281 taacgaaaga ataaaaccct aataacaaac caaatgtaag gctggatagc cctaatgtca 1994341 ttaaataata tgatgcgatt tttttcattt tttcaccccc cttgtttgat ttattcacag 1994401 tgctgttagt ataaattcac aacctttgta tttcttttat cgagatgtct tccctaacgt 1994461 gctatacgca atgcgctaat aaaaggtttc aaaaatgacg ttcttttatt agataatacg 1994521 ctggctgaaa acgcctctcc tgattggcca aagcgcgaat gaaaaaagtg catgaatacc 1994581 tgcccaacag acagaataag aagagttgat atttcaacac ttttcgtaaa ggggtgaaac 1994641 caatgagtaa gaaaggtatt caaaattcaa gtattgaaca aataagaaat gaccatgaga 1994701 ctgaaacagc ttttaaagca gatgatccta aaaaacacgg ttccgatcct aaaagaacga 1994761 aataagttct tacccccact aaaatatcaa taatctggag gaagtaaagt gactcaaaaa 1994821 aacggtgcag acagacctga tgattataaa agattttctt cattagacaa ggaatatgat 1994881 tttcagcaat ctatacgcag caatactgag acagaaagtg taaacactga aacacaaact 1994941 cataacaaag aaaacaaaaa tgacacaaca gatgttgccg ggaaatactt tgagccctca 1995001 gattataaag gaagcacgca attagaaaaa ggattggctg aaactcatga acaggtcagc 1995061 gatgactatt ttgaagggac aatcgatcaa aatttggact agccatacaa acggaactaa 1995121 cttaaaagaa gtcagttaac tctgttttta gaaacaacca cagtaaaagt agccaacccc 1995181 caccgaataa gatgggggtt gcacgtaagt agcctgttta atatttaaaa cgattaatga 1995241 cggtttgaag ttcttctgcc aactgagata gagattctgc ggcataggag atttccccca 1995301 ttgaatgaag ctgttcctgt gatgaatttg caaccgcttc tgtatttgct gacgtttctt 1995361 ttgtaccagc agccaatgta tgaactgtgt gctgaatcac ttcaacgcct gaagtaagct 1995421 gttgagttgc tgctgcaact tcttgtattt gagaagtgac ctgttccacc aggttcagta 1995481 tttcattgaa atttcctgtt gtctcttgag aaagaacaat acctgagctc acattttctt 1995541 gaacaacttt aatattattt accgtttcta tcgattcgtt ttggatggtc gctaccaccg 1995601 attggatgtg gtttgcagat ttatttgttt catccgccaa cttccgaact tcttctgcca 1995661 ccacagcaaa tccttttcct tgctctccgg ctctggccgc ctcgatcgct gcatttagtg 1995721 ccaacaaatt tgtctgctct gaaatcgtcg tgataagcga agagatatcg ctgatttctg 1995781 ctgtgctcgc taccaatgtt tgcaatccat tgccggctga atctacagat ttatcaatga 1995841 atttcatctg gtctaacatc ttgttgacgg acttagagcc tatttcagcc ttgtctctca 1995901 tcgaagaaga aagatccgct atgttccctg tatttgaagc gactgatgat atactgtcta 1995961 ataattcagt gatggattct gcgctctttt ctgtcattga gctttgcttc acattgctgt 1996021 cggcagccat ctgcatggct cgtgaaatat gttcagatgt tgatttcgat tcttccgcgc 1996081 ttgccgataa ttcttcagag gaagcggcga cttgttcaga tgagctgctg atctgcttca 1996141 caatttgagt taatgaatga gtaaaagaat taaaagattg ggcaagctgg ccaaattcat 1996201 ctttattttt cacaatgact tttttggtta aatcagcctc gccgtgtgca atttcctcca 1996261 gctgcttatt tatgcttctt agtggcacca taatggactt taacagcatt atgcttagaa 1996321 caatgcctaa tattactgat atccctgtga caatgataat gagcgattga ctcattttcc 1996381 cattgccctg tatttcatcc tttagatcct ctacctcttg atccaggcga tcagacagct 1996441 tattgacagc cggagctacg ccttcttttc ttattgttct ttcttctcca aaatggatgg 1996501 tttctgcttt tttaggattt gaagagtagg ctgttactac ttgctgattc aaagctctat 1996561 actgagtaaa acttgtctta atgtcttcaa tattggattg atacttctct tcatcaatca 1996621 agtcattaac ccggtcaagg ctctttaaga catcgtctgc ttttcccttc ataccctcgt 1996681 cgtattcttt gtctctggta atcaagaagc ctctttcatc atttgataac ccggtcaatt 1996741 catattggat gtgttttatc tctttttgga attccatttt gtctttaagt tcttcattct 1996801 ttttcacagt agaagaaatc ataaatactg aggagcctcc aattccaata attgaaacaa 1996861 ctaatattga tataatcccc agcaattttg ttttcacttt catgtgtcgt tttccctttc 1996921 cgcacaatgt aatggctgaa ataaaatatg ttcaagcgcg tttgaatcca attcgcttac 1996981 gctcatgtcc ataatatcga cacgtgttat caagttttat agtgatattc ttatatgaat 1997041 aagcaaattc tttacgtctc tgaacttaca gaaaaacctt aagtaaaatt tgcagtcttt 1997101 tgcggtatgt aagtcactct tattcgtttt tctaaaaaag gcttttccca cctcaaattg 1997161 gctgaaccgg ctgttttctc gaaaatataa tacaatacgc agcataatat gaaggagcga 1997221 aacttaaatg gggatcatca atggtaaaga attcattgac cgattgaata aactagaaaa 1997281 cgaaatatgg tatgatggcg aaaaaataaa gggtaacatt tctgagcatc ctgcatttaa 1997341 aggaataatc aaaacaaaaa gctcacttta tgaattgcaa acaaaggatg agttaataca 1997401 tgaaatgact tattgccttc ctggagatca taatcgaatc ggcctttcct atctccagcc 1997461 taaaacaaaa aatgatttga aaaaaagaag gaccatgatt gaacattggg ctagacatac 1997521 tcatggaatg atggggagaa gtccggatta catgaatacg gttatgatga gctttgcttc 1997581 gtcagcggag cttctaaaag ataaagagaa ttgctttcct gaacatatac tagatatgta 1997641 tgaacaagct gctaagcatg acctttcctt tacccataca ttcattactc cgcaagtgaa 1997701 ccggtcacag tcctattttg ggctaagtga aaaaccgata tctgctaaag tcattgatag 1997761 aaccgaaaaa ggtttaatga ttcatggcgc acgactgctt gccacacaag gcgggttgac 1997821 cgatgaaatc ttggtttttt cagcgcctaa atttttcttt gaaacagatg aagcttatgc 1997881 tttttcaatc ccttctaata caaaaggcgt aaaattcatc acaagagaat catttgtatt 1997941 aagcgactct tcctttaatc atcccttaag ctcaaggtat gaagaaatgg attcaattgt 1998001 ggtttttgat catgtgttag tgccgtggaa tcgtgtgttt ttttacgata atgtggaagc 1998061 agctaaagat tttatgacaa aaagctcttt tcatgccttt acctttcacc aggttgtcat 1998121 taggcaaatg ataaaaattg aatttctatt aggtgttgca cagcttcttg tcgacaccat 1998181 taatgtttcc gaatatcagc acatccaaga aaagctctca gaaatcattg tgggattgga 1998241 aacaatcaaa gccctcattg acaaatcgga aaatgatgct cagttagatg aattcggcta 1998301 tatgcgcccc tgtttaattc ctcttcaagt catcagtacg atcattccta agctatatcc 1998361 tcgatttact gaaatcatac aattaattgg agctagcgga atggtgacac tgcctaccga 1998421 aaatgcattt gactcagaga tacgggaaga tcttgaccaa tatcttcaag caaccaatac 1998481 aaatgctgaa gaacgtgtga aaattttccg tttggcatgg gatttaacaa tgagttcatt 1998541 cggaactaga caaactcact acgaaagata ttttttcgga gatcctattc ggatttcaag 1998601 caggctgtat accagttatc caaagcagga gcagttgaac atgattaaaa catttttaca 1998661 tgcagataca gaacattgaa aaaacagcgg gaaaagatcc gctgtttcgt attttttatt 1998721 caggaaactg aacatggccc ggtactgtat aggctttgga cgttccgctt tcaggcagct 1998781 ttggaatggt gtctttcaca acttttccgc ggatgtcagt cattctgact ttgagagagc 1998841 cagtacctaa attcgtactc acaaaatggt tatagtccat tttctccatg ttgatccact 1998901 taccatcctt ttcatattcc attttcataa caggatactt gtgatttctg acttggattg 1998961 ctgcccacca cctgctgctg ccttctttga tccggtacgt gaaattgccg gtgattgggg 1999021 ctttgacaac acgccattta atattgattt ttccgtcttt catattgccg attttacgga 1999081 aggcattagg tgacagatca agagctcccc gagcgccttc gggataaaga tcagtaacat 1999141 atacggttgt tttccctttt ggcccttcaa cttccaaata agagccggca agtgccgctt 1999201 ttactcctcc gtaattgaga tccgccggat ttattgcagt aatctccata tcggaaggaa 1999261 tgggatccag caggaaagct cctcctgaat agcctgaccc tgtatacgtt gcataacctt 1999321 catgcaggtc gtcatatgct gccgaagctt gcggggaaaa acagaagatc gtcaacaaaa 1999381 ccataccaac aaatgcactc atgatctttt tcatatttgg tcctcctcaa accagacttc 1999441 aaatgagaat cattatcatt ataagactca atccatctgg tttgaaagag gaaatagatt 1999501 catagttgat tttaaggcaa attcactatc attcatatat caaatgtagg tacttatgaa 1999561 aaagccaata caaatgaacg aatgtgcact tcagccgaat gtcttatttt tccctctcaa 1999621 aattcgcatt tcaataacga aatgaaacag gctgttggcc tgataacagc tatacaggaa 1999681 aagctatttt tccccgctca gtttcaactt agctgtcatc atgatgccaa agatcagcac 1999741 aatcggaacc caaataatga agtgataaaa atcaggctca gccagagcaa caataatagc 1999801 ccctacacaa tacaaaataa tagccagtgc tcttaacaca gtatctctta agaaagtctt 1999861 cttttgcttc ttaaaaaaca aacggccgga tatatcctct aaaagagaag ccaaagtgcc 1999921 ggtcaacaca gttgaagaaa tacctgcaat ccccagtttt tttgctgctg tagtttgaat 1999981 ccccatagaa atgctcatga gtataattag aatgtgcaca ggaacaaatg cccggtaaaa 2000041 agaaagacaa gcaaagacaa acaaaatgaa tgcttcaagt gcgagggctt ttgtcacagc 2000101 agaaggccaa agggtatttt ccgcctttcc gaccatcaat gtagcaatga tcacgccgca 2000161 tataaatccg attagcgcag tcaaggaatt aaaaacagtg acctgaatgg atttgccgat 2000221 agctaacccc aataatacaa tgtttccagt catattagct gtgaacacat gtcccaggct 2000281 taaatacccg attacatcca cgattccagc tgttaaacat aaaagtgata gcaaggtgtt 2000341 tcgataagct gctgcagtca acggtgtatc aatcctttct tctatttcaa ttgttagtat 2000401 gtcttttggc gcaatctcta ttttttaagt aacccaacat taattaggaa gatagaacct 2000461 attattcctt tccattaact gtaataataa tccccgcaag gaaatgatta aaattgaaag 2000521 gaagcatatt gtgatgaaac gactttgttt atggttcacc gtctttagct tgtttttggt 2000581 tctcttgcct ggaaaagcat taggtgcagt cgattttccg aatacctcaa caaatggcct 2000641 tttaggtttt gccggaaatg ccaaaaatga aaaaggcatc tctaaaacgg gcacaacggg 2000701 tggaaaaaac gggcagattg tttacattca aagcgtaaat gatttaaaaa cccatctagg 2000761 aggatccact ccgaaaattt tagtgcttca aaatgatctt tccgcatctg cgaaaacaac 2000821 agttaccatt ggctcaaata aaacactcgt gggctcttac gcgaaaaaaa cgctgaaaaa 2000881 tatttattta acaacttcat cagcttttgg aaatgtcatt tttcaaaatt taacgtttga 2000941 acacagtccg cagattaacg gaaataatga tatccagctt tatttagatt ccggtatgaa 2001001 ctattggatt gatcacgtca cattctcagg tcatagctat aatgcaagcg gaagcgattt 2001061 ggacaaactc gtgtatatcg gaaaatccgc agattatatc acgatcagca actcaaaatt 2001121 tgcgaatcat aaatacggtt tgattttagg atacccggat gattctcagc atcaatatga 2001181 cggctacccc cacatgacaa tcgccaataa ttattttgag aacttgtatg ttagaggccc 2001241 aggtctgatg agatacggtt actttcatgt taaaaacaat tacagcaata attttaacca 2001301 ggcgattaca attgctacaa aagcaaaaat atattccgaa tataattact ttgggaaagg 2001361 cagtgaaaaa ggcggcatcc ttgacgacaa gggcactggt tatttcaaag acataggcag 2001421 ctatccatca ctcaacaagc aaacctctcc gctgacttct tggaatcctg ggtcaaacta 2001481 tagctatcgt gtccaaacgc cggaatatac aaaagaattt gtcacgaaat atgccggatc 2001541 acaaagtaca actctggtat ttggctactg atataaaaga ggccctgcgt taaaaacgct 2001601 gtgcctcttt ttatactata ggctattttt aagcgatcct tgtaattcca tcaagatcca 2001661 gcgtcggtca aactaaaaag catatgttct tttccacaat aacttcttaa ctggctttct 2001721 tattatacca gtttatcgca agtgaaaaga aatcattgtt ctgaacctgt attaaatgaa 2001781 cgatcgtccc acaaactact taaaaacccc taaaaaggat gatggatatg tgcggcaggt 2001841 ttactttgta ctctgcattt gatgatatta ttgaccagtt tgacatcgat caattttttc 2001901 ctaaaggtga ataccagcca agctataatg tcgcaccatc acaaaacatc cttgcaatca 2001961 tcaatgatgg atcaaataat cgcttaggca agcttagatg gggacttatt ccaccttggg 2002021 caaaagatga aaagatcggt tataaaatga tcaatgctcg agccgaaaca attaccgaga 2002081 aaccggcctt tcgaagaccg cttgtcagca aacgctgcat cataccagca gacagttttt 2002141 atgaatggaa acggcttgat tccaaaacca aaatcccaat gcggatcaaa ttgaaatcat 2002201 ctgctctttt tgcgtttgct ggcttatatg aaaagtggag cacacatcaa ggataccctc 2002261 tttatacctg caccatcata acaactgagc ctaatgagtt catgaaagat atacacgacc 2002321 gaatgccggt tatattggcc catgatcatg aaaaggagtg gcttaacccc aaaaatacaa 2002381 gccctgatta tctgcaaagt ttgctgctgc cttatgatgc tgatgacatg gaagcatacc 2002441 aggtttcatc attagtaaat tcacccaaaa ataattcagc tgagcttctt gatgcagaaa 2002501 atcatatgta gtgattgaaa aaattctcta gcaagaactt gtcaaatagc tttgttcctt 2002561 aggtgccaat ccctctagta attatgaata tttagtacat agatcaatta gttatcttta 2002621 gcatcagttt gaaataattt tattatgtaa acttaaataa gcaatgttat tcctttcata 2002681 taaaatagtt tacattttta taaaatcgct tcacttttct attttgtcag caaaaaaact 2002741 gaaccacatt aaacttatga aacctgccgc acctgtggat tgcaaatatg atataagccc 2002801 atagaggtaa atccatacac tttccctcct aagaattaaa tgaaatttct ttcatcttac 2002861 atgaaggtct tctttctttt gtttatccag tgtaatactt aataatatgt tgatgaatgc 2002921 agctggaaaa tatataaatc ccactccaag aatgcctagt atcgtactta aacttactat 2002981 gtaattcttt gtcatcgttt gactgtcaat caatattaga agtgaaatca atccagctaa 2003041 aacacctata aaccaagcat cgccaacagc ataagaatca tccagcatcc ctaaccatcg 2003101 ccccaatata gagctcccaa tggcagtcaa actggataaa aatatgagtg ctttcatttc 2003161 ttctcctcct ttaaagccaa tcaaactggt agaaatcggc cattgaatcc ccattatcga 2003221 atggttacca tttcatttcc acattaacat tttaaagctc attacaatac gattcaagca 2003281 gaaaaaccct acataacgta tatataggga tttaataaaa cacaggccaa aattcagctc 2003341 tatctacttt aaaaagatat gaagggcagc tgtgtgatct gttacgtctt tacgtaccgg 2003401 gatatttcac aacaggcact ttcttcttgc gcagagaatc aagcatgact gatccagcat 2003461 tcaagttgct ttgtactaat tctttaggcg tcaatgccat ccactgattg agtgacacat 2003521 ctgcatagcg gttacttttg aacatttcta aaaaccataa tgtttctgta ccagtgtttt 2003581 gtatatagtg tccggcatta gaaggcacgt atccaacgtc gcctgctcta taatcaaatg 2003641 tgcgggcagt cccatttccg ataaataccg tcattcgtcc ctgtcctgtt agataatatt 2003701 gccactcatc gctattggga tgccaatgaa gctctctcat cgcgccaggc tcaatctgaa 2003761 caagtgcagc ggctatcgtt tttgaaattg ggaagttaga agaatccaca attcgtacac 2003821 tcccccctgg catttgaatt gggggttgat ttaacagctc gtgtttaaag gtcatgggga 2003881 cttttccata tggtgactga atgtcttcac tggcgactga tcccggcaca ttcccttggt 2003941 agatatagac ttgctcagac ggaagagagt tgaaagcatt ctccgggaca ccgaaatttg 2004001 cagacagaac atcttttggt gtgtgtgcaa gccaatctga aatggttaac gttgaaaact 2004061 cagaaaagtt cccatcatcg aaaacgagca gaaactcgca gtgttccaat ccctgtatgg 2004121 aatgcggaat tcctgccggg aagtaccaaa ggtcgccggg accaacatca gcaatgaaat 2004181 ttcgtccgtc ttggtcaaca gcggtgatac gtgcccgtcc caaaagcata taagcccact 2004241 ccgcttgctt atgccaatga agctcgcgga cgcctcccgc agttaagctc atgtttacac 2004301 ctgcaatcgc agtcgaaatc ggaagctgtc ttacggtgat ttctcttgac cagccgccgt 2004361 gatctaattt catgggagcg tctgagaatg aaaatctcaa gttaggaatc ataccctcat 2004421 ctgtaacagg cggaacaaat atattcggat tttgaatatc ccgtattata tttcgcgggc 2004481 ctgtatcaat agctccagct ccatcacttc gaataggctg cggcacgttt ctgtcttcat 2004541 gattgattgg ttgttgttcc aacagcatgc acctcgtttt agaaatgaac aagattttat 2004601 ttcagcctat gcagaatctt agattgctgt gcctaggaat ccgcaaataa aaaagtgacc 2004661 accaatgtga tcacaaatac atcaaataaa ctatttttta taccatggct tcttatgtaa 2004721 tttgattgct tctgtctgtt ttttctggcc tgtcctccac tccactttta ctaatacatc 2004781 atgacctatc acttcatctt caggcatata atcaaaggtg gaaatatggt cctccatgcg 2004841 tcccccaccc ggcatttcat cacctgtgta ctccgataag tcgtactcat ctacgttatc 2004901 atcttgatac ttttcgccat ctacatacag agtaattctt tcaacaacag tccacttttc 2004961 ttccttctta ctcccctgcc aatatagatt tagaaaataa ttgggtccaa ttgaagtttt 2005021 gtctgatttt tcaaggttag acatccacag tccgcttttc ccgctgccct catatttcac 2005081 tttgttccct gacaccatta caaataatgt gatgatgcag atgatcaaga atccagcaat 2005141 gatcaatagc catttcttaa tattgttctt ttttctcatg tttttcctca ctttcctaac 2005201 tttttagtag gaaaatacga tcaaaatgtt accgaaaaga aaataagaaa gggctaatga 2005261 tctaacagat gactgtctaa acttttgact taaattaaag tgctttctaa agacaagatt 2005321 aaaacgtata acagctctta aatgcatttt ttgtttcatt gagtcaagaa ccttaaaatg 2005381 gctttttatt attaaaaatc aagctagtgt attaagtaac ttttcaaatt tatttatact 2005441 catgatctcg tgagtcacaa atctcccatc aaaaaaaacg ctaaaagttg tccaaatagc 2005501 tggtgacttt tgtgcctctt ctttcgatga taactgaatt gactgaaatt gaaccccttt 2005561 cttttcagtc aattcccgca aatcatttat catgcccact gcaaacggac actgagctgt 2005621 atagtatatc gtaatcccct tttcattgat agaatcactt ttcacctggc tcttaaatgc 2005681 aggagaatct gcaaggccat tccaagtcaa agccattaat tgaaaataag gggcagcttc 2005741 atcttgtaga gtaaacccca tatgctcaaa gaaatgctta tcacttaaat agggcagttt 2005801 tttcttgcct gcgatatgga taatgccatc catgccgcac gctttcgcat ctgctataca 2005861 tttgtccaac aatcgtttcg catgaccgtt atttttatat ctgccagaca cccacagaca 2005921 attaatgtac ataaaattag gcgcattgat aggcacccat gcctcattcg caggtaggta 2005981 ttcaataaag acttttgccc gttcatgtaa gcgatagaac accaatcctt catccattcg 2006041 agctttgagc catctcttct tttcattaac tgcatgctca tattgtttcg tgcttaatgc 2006101 acagcaaata tgattgtctt caatattgtc ctttgtgatt tcaatgtagc acatctcctc 2006161 tttcccccct ttaacataat tacatggaat tcaacttcac actttacatg cctaatagaa 2006221 taaatacccg ttccaactta aatacttttt cttttccatt ttgccaatta actgtaaaac 2006281 ccttctttta ttcagatatt atcttgattc ctatatcacc catttcaaat ccaaagtgtg 2006341 ttcatctttg aggattagat gcactgctta tgctataaat acagtacacg aagtttttta 2006401 tttgaagtaa tatttgttac gggacagcaa tagtaaataa gtgataaaag gggaattaaa 2006461 cttggtggaa aaatgttatt cttgtttaat ttgcggatac aaaggattaa ttcaaaatcc 2006521 tttgtataaa ggcgagtatc aaaaaacgtt tgacatttgt ccatgttgcg gttttgaatt 2006581 tggctacagt gaggatcatg atgtgaggtt aggttttatt gtaactcctg atcatttaat 2006641 tgaggctgca tttcaattgt atcgcaaaca atggcttgag agcgggatgg taattgctca 2006701 tccggaagat attccagaag aattgaaaaa tggcaattgc ttaaaatttg aagttttgtt 2006761 gaaacaattg aaaaaactaa atcttgacat agaaaatttt gaaattagcg gtttttaatg 2006821 atgaaacagg ttgcacttgt ttaggtttca ctgtcattat cagtaaaatg ttaagttgaa 2006881 atgcgcaatc agtcacaaag tctctattcg tattcaataa agactttgtg atcatcgaca 2006941 aacatttcac tcccatcgga taaagtatcc aaaaggcctc ctctggttct tctctatagt 2007001 cattaatcac agtcactttg acatttgact cagctatgat tggttttcca acaatttttc 2007061 gttttttcct caggcaaagt aagagatcga atcatcaaag ccattccatc tttactgtct 2007121 aattaacgcc atcttcagtg aatttaaagg tctgttttaa attgcgtcct tcttgcccct 2007181 tctgtgtcca aattataaca acctctaatt cagaggcctt atctgccagc ataaaatgat 2007241 tgaacttcag cggtgagcca tcatttaaac tttcagctaa cattttagaa tcttcttttg 2007301 gtttgacaca attttcatcg ggacatccaa aaagcgaaaa ccttgtgatt gaattagggt 2007361 catttctata caattgcaca tccactgtag ctgctttttc ccctatattt ttgacttcca 2007421 aggaatatac ttgatattct cctttatgag gtctcgtaaa ttcctttaca ttttttgctt 2007481 cacttacttt tactgaccac tggtctgttt tttgtgtaat aggcaacacc gtaaaagtca 2007541 gggcatgcgc ttttgattgg caaaacgtaa atccaactgc tgtaaaaaca attacagaaa 2007601 ataataccct tttcacttca tttatccctc cttcctttca ctggccgctc cttaaagaat 2007661 tgattttgag caatctacaa gctctcttaa ccaaaacctt acctgaggtt ttgtctttac 2007721 tgctctgcat ttatttcttt cggtatccga gaaggagctt tggggatttt tctcaatctg 2007781 ctgttaatca catcagaaga gtatagcgta ataatcatac ttcccccata cctttttgcc 2007841 cgaattaaga ttggttggtt atattggttt tgaaagcgaa agtcaggacc tccccagctt 2007901 accgtcgcat cccgtccggg cggtacatat ggtacacttc tagtatgaga atagcgctga 2007961 acgatctgca gtcctgcacg atctactgca ttaaatagag ttgaggacac ctgacaaatt 2008021 cctcctccta caccttcaga caactcccct tttacaataa tgggtgcact tttatatcct 2008081 ttgttccgag ttctcattcc cacaacttgg ttaaacgaaa acgtctcatt agggaaaaca 2008141 acgtgattgt cgattgcttt tgcagaaaga gaaatattgt gtgaacggct tttattgctt 2008201 gagttaaaat acgtcacgta ctgaccaagc tgctgcgtac tgatgtgagc tagcagctcg 2008261 ctgtcaactt tcggataaat gttcatttcc ggcacttcta tcttggaggg accttgccca 2008321 taaaaatacg cataaaactt ttccataaac gcctgttgat acagtttgta gccaaccctg 2008381 cccgggacga tgcttccatg atcgttaagg acagcattta tcggctcacg gtacactttc 2008441 tgatcaagct gtttgatgaa tttactgtat ttttcatagt caaccattgg agtgccggga 2008501 agaggcattg taaagtcttc acggttaaca gtggcaatcg tccgtccttg ctgtgtgacc 2008561 gttaaactgt cctgcggctc actcggctga gccaataaaa aaagaccagt gatcaaaatt 2008621 tgtatcataa gtcggtttac ctcccaatca ttagtatgaa cagccgctta tcctttgatg 2008681 tatttcttcc catcgtttgt ttgaatcttt agacgttgat aaaaaccttc ataaaagagc 2008741 ttagctttat gttcacaccg atccctgagc tcactgaggc acacggttca ttcagtcggc 2008801 aagtttgaag tagttcagca tctcccagtg atgagggatg cttttttgtc ttgtcaaaaa 2008861 tgaaaagggt ctcctataac aacaaaaaat caatccattt caatattttt ttattgagaa 2008921 acgataaatt ttttgttaca ttcaattaga caacaaataa atgaggtgct tgttatgaat 2008981 cgaatgtcga caattttttt aaagatagct ttggttctta ttggaattcc aattcttgct 2009041 ttatgcattt ttttagtgcc taaggtagcc aactattcag cagaattatt tccaaatatc 2009101 gcttatataa aatatctcgt tttcatctat ttgtatgtaa cggcgatacc tttttacttt 2009161 gctctttatc aagcgttcaa acttttaagc tatattgaca aaaacaaagc tttctcgggt 2009221 ttgtctgtaa gagctttgaa gaatataaaa tattgcgcag tcactatcag tatcttttac 2009281 gcagcaggca tgcctgtctt ttatctgatg gccgagatag acgacgcccc gggtatcatt 2009341 gtgatcggat tggttattat ttttgcttca atggtgattg cggtctttgc tgctgttctt 2009401 caaaaactgt taaaagaagc gattgatata aaatcagaaa atgacttaac ggtctgaggt 2009461 gatgacatgg cgattattat caacattgat gtgatgcttg ctaagaggaa aatgagcgta 2009521 acagagcttt cagagagagt tggcatcacc atggctaatc tttcgatatt aaaaaacgga 2009581 aaagcaaagg ctattcgatt atcaacttta gaagcgattt gcaaggcttt agaatgtcag 2009641 cccggggata tattggaata ccgaagtgat gaagacacag gattcgtaaa gaaaaaatat 2009701 gaaggatcaa cagaaaaata aagtgattgg cggtgagctt atggacataa acttatatcc 2009761 atctagctgc tatactaagc gtccctttca tacacgaaga acacaactat ggaggaggca 2009821 tacatcatga gagccataaa acaaatcgtc cattttggct gggaacaagc cctttcatgt 2009881 ttgtttcctg ccgttatttt tgcctctttg gctattacgc aaatcatccc actgcccttc 2009941 ttgccgcggt atgactggct gctcattatc tgcgttctca tgcaattgtg gatggtgcgt 2010001 tccggtcttg agacacggga tgaattaaaa gtgatcacat tattccacct tattgggctt 2010061 gctctggaac tttttaaagt ccatatgggc tcctggtctt atccagaaga aggatactcc 2010121 aaaatatttg gagtaccttt gtatagcggc tttatgtacg caagtgtagc cagttatttg 2010181 tgccaggcat ggagaaggct taaggttgaa ctggttaagt ggccgtcttt ttttgcagtt 2010241 gttccgcttg ccgcagcgat ttatttgaat tttttcaccc accatttttc tatagacatt 2010301 cgatggtggt tatcagggct tgtcatcatt gtcttttggc aaacatgggt tacatacgag 2010361 gtgaatggag ctcgttaccg tatgccgctc gcactttctt ttatactcat cggatttttt 2010421 atatggatag cggaaaatat cgctacgttt tttggagctt ggaaatatcc aaaccaaatc 2010481 gatacatgga gtctcgtaca ccttggaaag gtaagttcat ggctcttgct agtgattgtt 2010541 agctttctta tagtagcatc attaaaacaa gttaaggagc agagtcccac aaaggcagag 2010601 atggatgaat ctttttctta gcatacgcat acaagctccc aaatagagtg aaaagcaacg 2010661 ttcaaatggt tgcttttttc ttttatgtaa ctctgccggt gagtattcat cttcttcaaa 2010721 tttcatcgca acacgataac tgattcagat tacaactgct ttcaacactt tgacaaactc 2010781 atgcgccgcc ggcgttatct cttcaaatga atgtgcgatg acgccaatat cgcgtgtgac 2010841 cctaggaaag atgtcctttt taatcaattg atgcgggacg gatgaaagtg taaagtttga 2010901 aatgatgccg atacccaagt tatttttgac catattaatc aaggtttcgg cattttgcac 2010961 agttaagttt tcctttaatt cgatgttgta ttgcgaaaat gcgtttgaca tcgcgatttc 2011021 atgaccgcct ttacaaaaaa tgaggtcatc ttgatatgtt tcaaggtcga catgcttttc 2011081 aagttttaat tcgtcacgct gcggcgggat gacggccacc atatagtcgt tacacaatag 2011141 ctgattttca aacggttcaa atggagatgc tgcgatcccg atatcaaccg tccgatcttc 2011201 aacccatcct tttatttggt cagaggttcc ttcgatcaat tctatgcgga tcagcgggta 2011261 gtttgatctg aatgccgcaa tcgcctgtgg catgatattt gttgaaactg caggaaatga 2011321 accaattttc accttcccgt ttaacagctt gttttcccgg ttggctactt gatatatttt 2011381 gctttcaatt cccttcattt gcctcgccag cagcaatatt tcttttccga tgtcagtcag 2011441 cattaaacca tgatgtttat ccctgatcaa taatttgagc tgcagtgagc tctccaggtt 2011501 ttttatcgct ttacttaccg ccggctgaga gatgaacaat tcttttgccg cttctgtaat 2011561 atttaatttc tccccaactt ttacaaatat gtgaagatgg ttcatgttca taaccatttg 2011621 gttatacccc caataataaa aatgtatttc agttatacat aaatgtaaca tatgatagaa 2011681 accagcacga tattttaaca agaaaggcgg cttcattatg gtaaaagtta tgctgggaat 2011741 catatctgtc acacttattt ggggttatac ttgggttgcg atgaaagtag gaattcatga 2011801 catccccccg cttttatttt cgggtttgcg cctgttcatc ggagcagttc ctttatttct 2011861 cattctcttc atccaaagaa aaaagctttc aattcaaaaa gaacatctca aaagctatat 2011921 catcatgagc ctgttgatgg ggctgggcta tatggggatt ttgacgtatg gaatgcagtt 2011981 tgtcgattca gggaaaacct ctgttttggt atatacaatg cctatatttg ttacggtgat 2012041 cagccatttt tcattaaacg agaaaatgaa tgtgtataaa acgatgggac tggtctgcgg 2012101 cctcttcgga ctgttattta tatttggaaa ggaaatgctc aatatcgatc aaagcgcttt 2012161 atttggggag ctgtgcgtac ttgtggcagc gcttagctgg ggaatcgcga atgtgttcag 2012221 caagctacaa ttcaagcata tcgatattat tcacatgaat gcctggcacc ttatgatggg 2012281 agccgtcatg ttattggtgt tttcctttat atttgaggcg gtcccttcag ccgagtggac 2012341 atatcaggcg gtgtggtcat tgctgtttaa tggcttgctt tccaccggct ttacctttgt 2012401 cgtatggttt tgggtgctca atcaaatcca agcgtcaaaa gcatccatgg cattaatgtt 2012461 tgttcccgta ttggccctat tctttggatg gctgcaattg cacgaacaga tcaccatcaa 2012521 tattatcctc ggcgcactgc tgatatgctg cgggattttt atgaatacat ttacattttc 2012581 acgacggaaa gtgtgaatga tatacatttc ccctgtcatt tgggcttcat gtgacaggag 2012641 aagactatta cgagaaagtc ttctagaatc ctgacgacag cctattaaac aatgaaaaaa 2012701 gctaatgtct gcatgtagac attagcttgg ctggcgttta ggctggtgag aatccagata 2012761 cttttttatt accattctgg ctgatcaaac tgaaaaccgt atagaccttt tactttaaca 2012821 tctccgcaat ctggatcttt tgtcaaaatc aaataatgag tcttataagg catcgtctca 2012881 actcgatcag ttgcactaaa atcaaaatga tcccccgaga agtttttttc actaacggtt 2012941 atttcatatc ctgacaaagt cattcgcatg attcttgcgt taattgtaca tccttcagta 2013001 tcgaaaatgg tgaatctgta cccaaagtga gatgtccaat ggtttgaatt taggtcatca 2013061 gacttcataa accatttttc attctctgtc attgtaaaac tcactttctc ctcatctttc 2013121 acgataacgg ccgaagcttc ccctacatgg atagtcaaag ccaaaagaaa tgtaaaagct 2013181 aacatcaaca tctttttcaa aagagttcct cccgatatct tttacttcaa tatattggaa 2013241 gggtcttttc tgatcaagac agtcttctcc aaatgaatct ttagcaccat gaaatgagcc 2013301 ttaataagaa cagttttaac ccaaatcaac ctctattcga aataaggctt accaatctat 2013361 attcttttta aaagtttctg catttcttta tttagctcct agacacatat aaaaaatgct 2013421 cctataagtt caggagcact acaaaaaact gctaaagtgt tttctatcga tttattgtat 2013481 tcattagctc aaagaaatat tcaggctttt gagtcttatt tagcttatac catgaacgca 2013541 atgtatctgg tgcaaataca tctaattttt tcaatacttc taccgcaaat tccagaggag 2013601 caattcctga tgcagtaacc aaattttcat cagatactgc aggccccttt tcatagaatg 2013661 tttctccttt gtaattaggg cagaccatat tcatatagtc gaggtcattg cttgtgtgct 2013721 ttctcgaatt taagtatcct tcattcgcga ggcccaaggt tgccccacaa attgcagcaa 2013781 tagtcgtgcc gagctttaaa gcgtcgccaa cttttttcaa gatcggctga tgaatatctt 2013841 ctccccaagt gtttcctccg ggtaaaatga taagatcttg actcccaaga gtacattcgt 2013901 caagagaaat atctggtttt atgcttaatc ctcccaacgt agttatcatt tctttattaa 2013961 cccctactgt aactactttt aaagatgctg catcttgttt aaagtatctc cctgagttta 2014021 gttccgcaat taaatatcca tattcccagt ctgacattgt gtgaaatacg tagagataaa 2014081 cttttctcgt ttgcatccaa taacactcca atcacaattg ataaagcttt ctaatagatg 2014141 actttgctga cagtcattgt cagctttttt gttgattcta ttcttatgcc cttgttctcc 2014201 caacttataa aaatataaga tcaattgatt ctatgtttac tagcgcaaag gggtttgtta 2014261 cactaactgt catgggaaac atttcaaagg taatacaaaa tcatttgaat gaggaggcct 2014321 gatgaagttg aaaactaaag cgtcaataaa attcggaata tgtgttgggc ttttatgttt 2014381 aagcattact ggtttcacac cttttttcaa ctcaacacat gccgaagcaa aatccataga 2014441 agacacaaac atggcaagct gtataacgaa taaaaaattt gttcaacttg agaaaaaatt 2014501 tgatgccagg cttggtgttt atgcaattga tataggttca aacaagacaa tcgcctatcg 2014561 gccgaatgaa cgatttgctt acgcatcaac ctataaagtt ctagccgcag ctgctgtcct 2014621 gaagaaaaac tcaattgaaa aacttaatga agtcatccac tacagcaagg acgatcttgt 2014681 tacatattct ccaatcacag agaaacacct agatacaggc atgagcctaa aagaaatctc 2014741 ggaagcggct atccgttaca gcgataatac cgctgggaac atcttgttgc aacagcttgg 2014801 cggccctaaa ggttttgaaa agtcactgaa acagattggg gatcatgtaa cgaaagctaa 2014861 acgattcgag acggatctaa actctgcgat tcctggtgat attcgtgaca ccagcaccgc 2014921 aaaagcactg gcaaccgatc ttaaagcctt cactttagat aacactctca cgactgacaa 2014981 acgcatgatc ttaaccgatt ggatgcgagg caatgctact ggtgacgaac tgattcgggc 2015041 aggcgctcca ataggatggg aagtcggcga taaatccgga gccggaagtt acgggacacg 2015101 aaacgacatt gctatcgttt ggccgccaaa cagagctcct attgttgtgg caattctgtc 2015161 aaaccgcttt acgaaagatg ctaattatga taatgctctt atcgctgagg ctgcaaaagt 2015221 cgtccttaac gatctcaaat aatatgttta gccttttgcc acaaaggaaa agacattact 2015281 tttttaactt ctaccgttca ttttttgatg aacggttctt tcataagacc tctagaatca 2015341 tatatttaaa caccacaaaa ttaaacatta ttataattaa cagcaagttt tcattttatg 2015401 gaacaagtaa agtttgaatc tgacaagaat taagactaag caccctaaaa tccgttttct 2015461 tttcttccaa gaatatactc cttagtgcaa gccattataa agatacaagt gaacatacaa 2015521 tgcagacaac tctcttaagt ctcttattct gtgaccaatt tgtaatactc atgaatatcc 2015581 ggactcactt ccaatatttc gtctcgttcg aagacactaa catatcaaac cacttgaatt 2015641 aacataactg aacttgatat tggtcactgg cagtttcaat gcaatagaac aacatttgtt 2015701 gtctcagagg ttatctatat gagaattcaa caattttttt ataataattc atatttttgt 2015761 atcgttgcac ttggtggatt tgactctttt cgtgtatgga accacacttt tattttttca 2015821 cctcttttga gatcatctgt gttatcaatc tcacttaatc ctacaattac tatgttattt 2015881 ttaaacttgt tcataagttg tccttcagaa agattgtaat cttcttttcc tggagctttt 2015941 gtatcggtaa tgagaattgc cctttcattg tctttaagca cgacatagcc tactaggctc 2016001 tgcatctttg tttcgtctcc gttttgttca tttttattgc agcctgcaag gaaaataatg 2016061 agcataatga gcactatcaa gcttactccg attttaggca tctttcttcc tcctctttaa 2016121 actcatcttt aaaataaaca acaggatatc acccaaccca tctacttctt tttgcaattc 2016181 ataacagcag catactcatt ctccaattcc tcaaccttct ttttattctt tctcaaatat 2016241 ttgcatgtgg tagccctcga tattatccgc ttactcattt ttgcgctttc aaatatatta 2016301 ttgaaggccg cttctttctg gattccagca taaatatact tatccttact gtcgtttact 2016361 atcgcaactt ccattaaaat cgagattttt acttttttta tgatccatta ttcacttcca 2016421 aaataacttc caattacaac ataatatatg tataaattgt aaatggagtt gatgtaattg 2016481 aagattagga aaatcttatt gagttctgct ttatcctttg gcatgctaat atccgcggtt 2016541 cccgcattgg ctgctggcac ttcgtctgag gttgcagtaa aaaatgaaga atatgattat 2016601 gacactatat accgcattag tcctctgcca atggacttcc agccaacaat agaatacaac 2016661 ggttatactt atacgcttac acgtcattat tttgattact caatcgggtt ttacacggct 2016721 atttatacaa aagttgttta aacttataaa ggagcttttt agctcctttt tctcttgttt 2016781 taagcaaggt atttctttct atgtggtccc ctatcaaata caacatcaac attctccagt 2016841 tctctttgac acgaacaaaa tctaaagttt ggttttaaat gctggtaata aaaaattcac 2016901 tttaaagaag tgccgcccgc aaaatacggc ttttgtacac tacgccaatt ttatattgaa 2016961 aagccagacc tcctcaaaga ggttccagct tttcttaatg tgctatcgat cttcgttagt 2017021 tcaacgggaa ctttatcatt cggtacaaat gcagcctccc aacttctagt tagggctgat 2017081 ggcggaatat ctgacggttc tctacacaca tcagacatta gaagatttca atgtagcctt 2017141 ctgtaccatg aacgcgaatt cgttgcccat cttttatcag cttggcagca ttttcaacgc 2017201 caacaactgc aggtaagcca tattcacggg ctataacagc tccatgggtc atcagccccc 2017261 caacttcggt gactaggcct tttatggata caaacaatgg tgtccagctt ggatcggtaa 2017321 aggaggtaac taatatatct ccatcttcta aatccgcatc ttccatgttt aaaatgacac 2017381 gcgctcgccc ctctataact ccggaggaaa caggtagacc tacaatcgct ccggctggga 2017441 gattttctcg tttatactca cctgtaacga tttcaccatc agacgtgata acacgtggtg 2017501 gagatagttt ttcatataat gtgtactcgt cttttcgtgt actgatgatt tgataatcca 2017561 gtttatgtgt gcgcacgact tcgtgaagtt cttcaaaagt gagatagtat atatcttctt 2017621 tttcatgaat aacgcccgct tctatgagtt gttcggcttc tttcagtaaa gcctgcttat 2017681 aaacgaagta tcgattaacc atgccgtatt ttggatattc cctaaacccg ctgaaattcc 2017741 ggatgatatc tatcgctcgt tttgtttctt tggctttttg ttcaccatcc ggtaattgct 2017801 tcaatcgatc taataactct tgttctttct tcaaagcttc ctgtcgccct tgctcaaatt 2017861 tccgatggcc gacattaggc tcaaaatttt taatattatt aagaatcatt gggacaagtg 2017921 tagttggttt ttcgctccat cgagttcttg tgatatcaat ctctccggta catcgcattc 2017981 cgtatttgct gagataatca tagatcgcgt ctcgggtttt gcttccgcca tcaaacttag 2018041 ccagttcatc caaaaagtta tcatctttta catgttgtaa gtaatcaatt acctctggat 2018101 aaggacgaat cacatctgcg acgtctaata gcgcaagacc catttctgaa gtaatattat 2018161 ggggtacaga ttgagaaagc gtatctgctg cgtttttttc acctaaccac tcgttcattt 2018221 tttcgttaat ccataatgaa gcattcatag cagttcgaat tagaaccgaa ctttttgggt 2018281 taaataaaat cttctttaat tcctgaatat cttccagaat aaaacgaaat aaatctgatc 2018341 ctgatttcgt ttggatgttt tgttttaact cttctatcga tgtttgactg ctctcaatca 2018401 aatcagacac gattgtcgga tcgttttcaa cttgagccgg catatctgca ttgcctctgc 2018461 tgggatttgg tgctgtttta tcatttggta tcgactttat gaaatctcgt cgctttatta 2018521 tggtcataag tgcgtctttt aagagctgat cgtgctgccc catgcctttt aagaaaactt 2018581 ctctgctgtc aggggatgcc agatgatgtg tgacatcaac aaatagcctt ccaccggctt 2018641 tacgcatggg tgcaacagtc gtcaacagaa aaaaagacaa tcccagtggt tttatgggat 2018701 ccgtcatcat ttgttgatga ccaacagaaa tatagacgtg attttcttgg tcactcgctt 2018761 cagggatggg gaataaagta gtgattggac gactctgtac aatataaaaa gtatcgcggg 2018821 ccaaacacca ttcgatatct tgcggctggc cgaaatgagc ttcgatctgt cttccaatgc 2018881 gtgccagctg taaaatttgt tcatcagtca gtgtttgagc cttttgctga tcagaatcga 2018941 tctgctgtgt ttctgttccg ccttcttttc gtccgtagat agccattttt ttagttgcta 2019001 ttctcttatc gatgatttgc ccatcctgta ctttaaaaca atcggcagat accaagccag 2019061 aaaccagtgc ttcaccaagt ccaaaaccgg catcgatgga taacaccttt cggttggagg 2019121 taatcggatc agcggtaaat aaaatccccg aagcctgagg gaaaaccatc ctttgaacga 2019181 taacggataa atagacttgg ctgtggtcaa atccattttg catacggtaa ataaccgcgc 2019241 gatccgtaaa tagggacgcc cagcatttac tgatatgctg caagattgca tcgacgccgg 2019301 taatatttaa ataggtgtct tgttgaccgg caaaagaagc atgtggtaaa tcctcagcag 2019361 tcgcactaga acgcacggca taggcatgtt cctcgccaaa ctgggagaga tattgagcca 2019421 ctgctttcac aacatcggaa ggaatgtcta cttccataat gatttgccga atcttccggc 2019481 tgatgttacc aatctgatct cggtcctcaa cttttagcat ggtcaattga tccaacaaca 2019541 cttgtaacgt ttcgttttgt tcgatggctt tttgatatcc tactgttgtg acacaaaatc 2019601 cttctggtac ttgtatacct tgaatttttg ataattcccc taaatgtaac ccttttcctc 2019661 caacgagcga aagctgtgtt ttttcaattt catgtaaacc gagaaccaaa gaactcattc 2019721 tacatctccc cttcaaaaaa aaatattgac aagagcttcc tagcaggata taataaaatt 2019781 ataagatgga tatctataac tttttaacta gaaagcgcac gtagtgtgat tatatcaccg 2019841 tgtctgtttt tgtgcaatat aaaaagaacc tgggaaattt caccaggttc ttttcttaat 2019901 ttccatagct agtcgcatta aaaaacttgg tttgagctga ttcaatcctc taaggaaatc 2019961 ctaaagttgg gttctttttg aacttacttg ctttgttcgt agagtcccca ttcataaatt 2020021 ggactttttg ttcttaacag tcccaccttt aactagtata aagttatgag gatctggtta 2020081 actactagat atttttattt tgaataaggc ttatgtttga taaagaaggg ttatgtaaag 2020141 gtgtctgttg tgagcaagcg ctgactacaa aaaattgata gcattctcat ttaaatacca 2020201 ttctattaac ctatagggaa agttttaaaa ccagatggag aataccctac ctccagcaat 2020261 tccaaggccg ttcacctagt agaaaacaac ctttaaccat tactaacgat tttaataatc 2020321 attgattata aaacttctca aggaacgatc agcagcccgt tagctacccc tgattaagga 2020381 tgatctgtta ccacactgtt acgttagaac ttccactact ttgatatcct tctgtcgcca 2020441 tgacttggta agcccaatta ctgcccagat tcattccatg gctcttccat gcgttcacat 2020501 gattgctgaa agtgattgta gcgttgcttc cggttggtct cttcgactgg cgaacactcc 2020561 agtactgcgt aaaagtagtg cgatcgccat caatggaagg tgcgttataa cgtgtagttg 2020621 tatatatgtc atatgtaccc ccatcacttt ttacagtacc tttatacgtt ccagtaggtc 2020681 tataagtacc ccatgaatcc actacataat attctatgag aggtgatctc gtccaaccat 2020741 ataaagttaa atatccattg ccattcggcg cccaaactcc ggcattatag tttatcgtcc 2020801 taaatggcga acctgtagtc caacctttac caacaacaaa atttccggta ttagaccaat 2020861 taacactgta attcccgcca gacccattga cagcgtttac tataccgccc ccatcagtcc 2020921 aattttgcca gtagtctgtg ctagctgcag aggcggttgc cgaaaacaag ctaatactca 2020981 ttaaagctgc cgataatcca actaagaaat tctttttaaa cttaaacata tgttacctcc 2021041 tataatattt tttccgactt tgaggtagca ctcgtataca tttaaaacat tcttaattac 2021101 taacgccaaa gcttttgatc gtccccttca gtataatacc acgaattcat gagcaaatat 2021161 taaaagtatt tgtaattcaa ttacaaatac ctagaaacac attataagtg gtcttcttcc 2021221 accatatcct gatccttttt tcgcaggatc acaattcttg tttctaattc agatggagta 2021281 atatctgcaa tgaattccca ttgaaccatt tcaaataaag gagatataca ttagagattg 2021341 tgaaattatt gtagctgccg cttgtctaat gaagggaagc aaatttatga agaatatgaa 2021401 gaactgaaga agaaaacaat taaggttata ctaagaaaga actgctcaat taaaattatt 2021461 gaccaaattt gaggatgata gcttagatca gttttacaaa gaagttgcaa gatttttatt 2021521 tgaaagggct ctgaaaaaga aaaaaaagaa ttgacaatca gggtaactgt gggatgtaac 2021581 cgagcctcca attcaaaata aatatcttta actttctttt tttatttaaa gagggactgt 2021641 atatccctct ttaaaattaa gctttagatt gctgctgaaa gtaataaaaa ttgtactttt 2021701 gatcaaaccc ttcttcgcta ccacaaagaa aaataatgaa ttcaataaat gcgataatag 2021761 aggggatacc agtccagcaa aacaaaatat atagaatacc ttgtcctact cttcccaaat 2021821 aaaacttatg tattcccaga cccccgaaga aaaatgctaa taatgccgct acaattttgt 2021881 tcttcttgct taccatgact tcctcctagt tcattgctac catttttaaa gtaatgcttt 2021941 cacattataa tgcattttcc gccagaaatc gtgaaaattt tgaaattctt ttgagatttt 2022001 ttattttatt gagaaatgaa agctcatata attgaactag atggttttgg gaggcattta 2022061 ttcaaaatgt attgccaaag attacggcaa ttacgaaagg cacacaaatt aacaatggaa 2022121 cagttagctg agaaaattgg aattgcaaaa tcaagttacg gcgggtatga agctgaaagc 2022181 aaaaaaccac cattggacaa gttggttatt ttagctagac tatatgatgt ttcagttgat 2022241 tacatacttg gattaacaga tgatcctgat cctaaagtgg aaagaaaaaa tctaaaagag 2022301 tttttagaaa aaccagatat tcactgggat ggatataaac ttacccctga gatattagat 2022361 cctatacgga aaattttgaa gttggttact gcaaacaaca attaaaaaag ccctcataag 2022421 ggcttttgca taaaacaatt atttcattga attttctgga ctcatttcaa gaagtttatt 2022481 catgatgata gctaaacttt caccagcttt ttgtagcttc tcacctgctt ttatcagagt 2022541 aattaaagca cttaaaaagt ccactaagct attttgattt attgcaactg tttctttata 2022601 agctttgtaa gcttcttcaa actgatcaaa ttgcacacct ttcatagcaa caacagctaa 2022661 tttatctgaa atatttccat atgactctgt taaactaaaa aatcttttga cattgattag 2022721 taaggcaatg cactttaaat aatcgtgccc cagaccaata tgtaaattgc ctgcagcaaa 2022781 cagcaaatcg ttcaaaactg tgtacggttc accattcctt gcaactgtct caatcccttt 2022841 gtataagtat aataaaaaga caaatgaatt tttatctgtg gaacgctcag gtaataagga 2022901 cactataata acttacttta agccaaaaca tccaaataaa aaggctggtt ataattatta 2022961 taaaaatcaa taggaactat aaatatataa agagggattg ctatgccaaa attatataca 2023021 tgtttaattt gcggatataa aggattaatt caaaacccat taaacaatga tggtgagtat 2023081 caaaaaacat ttgatatctg cccttgctgt gattttgaat acggctacag tgaagatcat 2023141 gacgtaagct taggttttat tgtaactcca gattatttaa ttgacgctgc aattcagtta 2023201 taccgaaaac agtggattga gaatggaatg aaaactgcaa atcctgaaga tattccagaa 2023261 gaattaagaa acggtgactg cttaaaattc gaggtgttgt taaagcaatt gaatagccta 2023321 aatctcgata ctgaaaactt tgaaatcaag ggatttaatg gttattaagc agatccaagc 2023381 ccccatatgg gggcgttctt attattgtac agtctatcag aactatttat agaaaaacta 2023441 tttaatgtat tgtataaata tcactgacct tttctttctc cattcaactt ccttaaccct 2023501 caactgtttg ctgctgcatc acattcctcc tttttgattt ttgtgtatca agcctgtaca 2023561 atattcaaaa accctaaagg atgatgaaca tgtgtggcaa gttcacttta ttttctgagt 2023621 ttgatgacat cattgagcaa ttcaacatag atcaattctt acctgaaggt gaatatcacc 2023681 ctagctataa tgtcgctcct tcacaaaaca tcctgacaat tatcaacgat ggatctaata 2023741 accgtctggg taaacttaga tggggtctta tccctccttg tgctaaagac gaaaagatcg 2023801 gttataaaat gattaatgct cgtgctgaaa cattggccga gaaacccagc tttcgaaagc 2023861 cgctcggaag caaacgttgt atcataccgg ctgacagttt ttatgaatgg aaacgccttg 2023921 atccaaagac taagattcct atgcggatta aacttaaatc gtcgaatctc tttgcttttg 2023981 ccggcttata tgaaaagtgg aacacgctag aaggcaatct gttgtacact tgcacaatca 2024041 tcacaataaa gcctagtgag cttatggaag acattcatga tcggatgcca gttatcctaa 2024101 ctgatgagaa caaaaaggaa tggctaaatc ctaaaaatac tgatcctgat tatctacaaa 2024161 gcttgttgct gccttatgat gctgatgaca tggaagcata tcaggtatct tcattagtga 2024221 attcacctga gctcattgaa tcccattaag taccactgcc atatcgcttt atataccacc 2024281 tcctcttagc taatatgttc taagtaggag gtggtatttt gtttgtatct ccaatgctat 2024341 tgcattcaat aaaagagcct tttgatgacg agagctatat cactgagctt aaattatcaa 2024401 gactaaaatt aaaataaggg ctcatacata gttgatatat ataatatgta ttgagacctt 2024461 tattgaacaa acgccccgtt tgttaaagtg gaaatctcta taattaatag ccgactttta 2024521 aaagttccaa tctaaaatta tcctctaaat cggctagctt cattaacttc tccgatatac 2024581 ctttccaatc tttatttaca gacatagaat gacatatccc aaacacctta gcctgttcag 2024641 tcttcaacac tgataaatgt gaatgcctat ctttaaaata cattgcataa tcgttggccc 2024701 ttcttgcact taattggaaa aggaagaatg ttgtatgcct tatagtatca gctgtaatag 2024761 gggcatttaa taattgatca gcataaaaac aaattgcttc ccttccaatt aaccctatat 2024821 ccactttttc gaatttccga taagttctct taaaataatc aattgctctc tcgtatattt 2024881 cgttattgtc taatgtgaca accttttttg ctgtagacca atatttattg attcctttcc 2024941 tatacggaat cctttccgcc atccaagcct tcttaaattg gtccagtgat aatggaacaa 2025001 atggaaagcc tgctggatct tgcacataaa tattttcatt atccatttgg taccctagaa 2025061 cataatggtc agaaccattt aaatttttat gattcggatg gtatgttagc tcccccatat 2025121 ctaaagggcc tagaatgaca gggttttgtt tgatttgctg ttttaataac ggaaatgggt 2025181 catctaagtc actagcttgc tgatgttctt ctgcagtaaa tccaaggatg tttaaagcat 2025241 aattgatacc atcatcagga tctctcatac taaaataaag gtttttttca tattctatca 2025301 tggcacctaa cccaacacca gttaatatct ctacaagttg aggagataca ttttctccta 2025361 ttgatgaaag aaacattgca gttgaatttg aataacagta atggccattt cctatataca 2025421 ctaacatcac ctccgggtag ataagttaac cttacaattt tgaaaattga aaatccatat 2025481 taaattgctc cgttctcgta ttcatcatct ggatcatttt tatcaacaat aatgatcttc 2025541 tcgccaatct ccgttttacg atcgacctct acgtattcgc gcttgatgct gctaagtgtt 2025601 tcgtcagcca gtacgtgaat cattacagtt gagttcgctt taatttccgt catttactgc 2025661 accctttata ttttttttat gttttttcaa ttctttttag attttcatat tggatttcac 2025721 tcttttaatt atagaggcgt gtcatacaca tgccatctaa gagagatagg acaattttgt 2025781 cttggaggtg aaagctaatg aattttcttc ttgatctttt tacaaattgg acttttgata 2025841 aagtcctgga ttatacacta gctgctgtaa tttggtctgt atttaaatcc agatcaaagc 2025901 agaataagta tccaggctat ttcgagaaaa tacgccgcta tagaaattta catccccttc 2025961 tgcgatcgtt atcgatgcgt gtacttttat cgataacgat ccatccttat atgtttagtt 2026021 aaaaactatc ttttatttag acttaatggg ataaaatctt cattgtaaaa ctcttcccac 2026081 tcagcaatta agtttctata atagttttgg ttagagtcgg ttggcataga ttcaatattg 2026141 tcaaaaccat taataccgac atctaattct actgtcacta atccttggta aaacttctta 2026201 taattctttt taattacttt gaaaaattca acatcaaaga agtcttcata ttcagttgct 2026261 ccactccaag aatcataaga ggacttaaca cgataattaa aaagaaccaa aactaactca 2026321 tctttcacat cttttgatat ttgctccatt aattgattta gtccttcact ggcattaaaa 2026381 tctacaatgc ttaatcggaa gtcaatccaa gtaacagctt catcttttaa ccttccttct 2026441 ccgtcttcat tcacttcaat taatacatat ctgtcagcca taattccctc ctaatttatt 2026501 tgtttaaaat cacgatttta actatttatg atccattagt cacttccaaa gcaacttcca 2026561 tttaactcat aattaatata taaaatgtaa atggagttga tatatttgaa ccttcgaaaa 2026621 attttattga gttctgcttt atcattaggt atgctggtat ctgctgctcc tgtcttggca 2026681 acaagttctt cgtctgaagt gatagtaaaa agtgatgaat atgattatga caccatatat 2026741 cagcttagcc ccctaccaaa cttcaagcct tctattgaat acaatggata tacttatact 2026801 ctcacacgtt attatttcga ttactcaatt cagttttata cggctattta tacaaaagtt 2026861 gtttaaactt atagggagct tttttagctc ctttttcacc tttttaagca agatatttct 2026921 ttctatgcgg tcttttatgt atgaaatcaa atgctttccc taattccttc tcttctgtta 2026981 ccgctgagtc catatcttat attgcatcta aggtttagtc agtcgagatc attgaatata 2027041 tagtacttta ctcagaacat tttgcttatt aaggacataa taagtgttcg tattaatttt 2027101 tcctgttacg ataacgatca aaaacaaaat aatttatctc attttaagac agaagttatt 2027161 ctgctttttc aaaaaaatat tcttgatttt ccctttttta gatgcatcca taaagcattc 2027221 gatcataacc attatatgta actgaaatgc aggtataaga gttattatat agggattaca 2027281 ctaccattat ctgggggtgt attaacatcc aaatactcaa aagcaagaac aaatgtaccc 2027341 atagcacttc catttccaca ccctatccaa attttcattt tcctaattcc acatcaaaat 2027401 cacccttttt cacatcgtaa tcactatcgt aaaagcctat agtatcaacg tttttccttc 2027461 ttaaaatttt ctttttttat aaatatcttc ccaaaacaac cactttcccc tactcccgct 2027521 tatgttttac gatcgtttac cccctattta ctaattaaag tatcaaaaat tcttatgttt 2027581 actgtctttt tagctcatta taaattttta cgataagcaa ttgcctttgc ttttggatat 2027641 gacttgactg tatttggtga cgatttaaca gagaaattta atgctcttct gactttttta 2027701 actgcattgg gcattattgt tgatccaaca actcaaggta tttctgatag tgaacaagca 2027761 atggattatg attcaccgag ataaacccca tacccttctc ttgattgagg agggtatttt 2027821 tttcgttttt tcaaatgaaa aaattgcaga aaactttaca tccttttaca attttttcaa 2027881 tgactatgtt atgattgttt tcgagagatt tttgaaattt tcagaaagag gggtttaaat 2027941 gagtaagatc gcttctgaag ttgtcgctac tacactgaat gactggtaca ttgctataaa 2028001 aaaacaaaag gttgatgaat caataaaata ttattcagag ataaagaaac tttttgatga 2028061 aatggaagaa gatcaagaag ttcttgcgta ttatagtcta ttagaagaaa gacataaaat 2028121 gttgctgcat tcttcacgag gagagccttt acaaaagcac acctatttta ctgaagacaa 2028181 tcaaaacttc ataacaaaaa caaatgataa attagaatac aacttttatt tatttgaagc 2028241 aatgtacgag gcatacaaca aaaactatga tcgagcaatt aacctatatg gattagctga 2028301 gaaaaagctt gcagaaattc cagatgaaat tgaagcagct gaattttact ctaaagtctc 2028361 ttacttatat actcttgtta aacaaagcat tgtggcacaa cattatataa aaaatgcaat 2028421 ttcaatatat aagcgacacc ctgattataa atgcaaacta gctacatcaa caatgattgc 2028481 agctgcaaac tatgctgata tgaaacgatt tgaggaagca gaacaatatt acttagaagc 2028541 aattgatatt gcaaaagaaa caaaagatga atttttaaaa gctcaattat ttcacaatct 2028601 tagtatcgtt tattctgatt ggaacaaacc tgataaatgc attgaatctc ttgaaaaagc 2028661 aataggaaat gaatcttggt tacattcgat ttattatata aattctttat tcatgatgat 2028721 taaagaactc tttaaaattg acgaaaaaat gaaagccatt aatttttaca ataaagcaca 2028781 ggaaagactc atattaatgg agaataaagt atacgaagcc aaaatcagca tcctgtataa 2028841 cctttattgt ggggaattaa aaaataattt caataattgt attagtaata ttgagttttt 2028901 aaaacagcaa aatgaacttg aaagtgtaga tgaattgtcc tacatagctg caaaaaggtt 2028961 tgaatcaata ggtgcttttg aagaagcaac gagctttttc aatgcgaaaa tttgggctga 2029021 acagaaaatg aatcaggtgg agggaatctt atgaaaaaac ttgtgctttg cgtatctatt 2029081 ttagctgtga ttttaagtgg agtagcttta acgcaattga gtacagattc accatctaac 2029141 atccaggtag ctgaaaggcc agtcggaggt taaaaaaggt tgattaatta atttagccct 2029201 actcaaacat ttgagtgggc ttttatttta tgatttatgt ccaccggtca gccctgctct 2029261 gtggagcgca gtacctgcaa acgtaactga gatacttctc actgtttttt gcccgagtaa 2029321 aacttattaa agaacatcaa gcaacactta taaatatcca tcgtgatatt tgtgggaaaa 2029381 tcaattgttt tggatcgatg aaaaccaccg ccaagctcat ctttactgta tccaattcct 2029441 agacttattg ttcgaccaac tttattatat gtacgtgccc ttcttgcgac ttcctcacaa 2029501 atctccaaga gcacagcttt aatctcttct ctctttgtat aatccctaaa caaaatctga 2029561 ctcttaccaa aactaatctg cccctgcatc aatggagctc ctatttcaga taaatcaatt 2029621 ccgtgagcat gatagtacaa ctggtttccc attattccga acttcttttc aagcagctct 2029681 aaaggaaatt tagctaactg acctacagtt gatataccca ttcgattcag atttctttcc 2029741 atcctccctc ctatccccca cattttagac aaaggtcgaa ctttccagag tctatttggc 2029801 acatcttcat atctccaacg tgcaatacca ctctttgttt tcttactctc caggtcaagt 2029861 gcaagcttac taagcaacat attgtcacca attccaactg tgcacatcaa accaaattct 2029921 ctccacatgc tgctttggat tgctttggcc atttcttcag gattctcttt tcctgcatct 2029981 aaaaaagatt aatcaattga atacgtgtgg acacattttt caggaacaaa tctgtaaaac 2030041 agctttgtaa tctcagttga aactctgatg aaaagcttca tttgtggatt tacaatgtat 2030101 attcttggat cttcaggtat ctcaaatagt ctcgatcctg ttttgattcc aaaatctttt 2030161 ttaagtgcag gagatgcagc taacactaca cttccctgtc tatccgtatt ccctacaacg 2030221 gcaagataac atgttaaagg attaagcccc attgctacag ccgatacaga agcataaaag 2030281 gatttcatat cgacacagag tatattctca cgtggaaatt gtgagtaatc agtcattgta 2030341 tataactctt atgatgttat tcatgttgat ataaactgta ttgtcgttct ggtcttttac 2030401 gtgaagcttt tgttgttcaa aattaatgta atgtactctg ccggtaacat tttcaacaaa 2030461 tcccttgtta aagagtttga atttcaactc tttattaaat tccaatgcct cagaaacgag 2030521 aatatccatc tcatcaattt gtttgtcatc taaagatggc ttttcaactt ttgatccatc 2030581 aatcaaatct tgtttaagct gtattaattg ttctagcatc attgatgtcc attgatagtt 2030641 cctcgatccc taaacatatc gactcactcc ttgattgatc taatatcaac agaacaaacg 2030701 ttccttattc aatatagatc agaacaaaag ttcgatgtaa atgttggtaa taaaatataa 2030761 aggtcaataa tgatatccgt agtattaata aaggagagat tcttttcgac gagggagagt 2030821 gtgatggtga atgaagaaga ggttaattgg atttttggtc ttagttcctg ctttgattat 2030881 gtggggtata actttaatcg aatcaaacaa aaagacccct gtagaagttt tagaaagtgc 2030941 ttgggatgaa tttgggttat ttagttttga aattggaata acagatccgg caattacaat 2031001 aggcatggat caaaccaaaa gtgaagcaaa actccgtgaa tatttaaaag ataatctgtc 2031061 tagagaagcc aaggaaaaat ataagattta tatattcaag gatgatactg ataagctgga 2031121 gaaagagcat caagaatatt tgaaagaaaa taatctcaat aagtaaaacg cccagcaatt 2031181 aaaactggac gttaaaaaac attagttatt ctttattttt ttttagtatt cacacgtaat 2031241 ctctctctat cttctttaaa agaggatatg tagtttttag actctaatgc agtcaccaac 2031301 gctttattag ttctattatt tgagatcttt attcgtctgc ctttttcagc aatttcagag 2031361 taaggttccc ctattttagt taaaaattca gtaattgatt cattatcaat atgctttatt 2031421 tgtccagcta gcaacgataa cctagtatcc aatgttgtag gtgattcaag caaaaaggtt 2031481 agtagttcat tggtgatttt caggttatgc tcattaataa aataaattgt atctttaaga 2031541 atatcattat ttccatctgt caaacagtta gaatttaaat gttgtacaaa tatttctttg 2031601 ttaaattgag agagctcgtt gctatctatg agttgcttta tatcattggc atcaagggaa 2031661 aaatcacctt gtttatcaat aaactcgtca gggtttctca aagcgagttg gatatgaagt 2031721 gtatcaaaat ttaattttaa ctctttaaaa ttttccggtg ttagagataa caaatcatta 2031781 tcaatcaata attttgctct tttttcacta acatttccga gcggaaagta aatccaactt 2031841 tgaatactag caattaacac ttcgaatgtt tcgtctgtaa tatcccgact attaatgatt 2031901 tcttctgaga tatcttctaa aatcgcttcg tcaaatttat catcaaacgc ctctatatta 2031961 tttttagaga gctcttttct attaacagga ttgtttaaga aagctattaa gaaatcaggc 2032021 atttttttat tgtattctac ataagaagta ataacgtttg accagcatgc aaccatttta 2032081 ttttcacgga tcacaattgg ccataactct ttaatcaatt caccaatatc cgagatggca 2032141 aaagtttttt tcatgatcat tgcatgcttt actctcttat ctaaatcctc ccgatttaat 2032201 aactccagaa aactttcctc tggttcctca atctcctcag taagtaaaac tttttcaaca 2032261 aatatatcaa tattgtcatt tacgtaattg ataacagcct gctgatcaga gtttttaact 2032321 gcagcatacg ttatattggg agcatcattt aaaataactg ataaagtttt gatattaatt 2032381 tcgtatagat ttcgttgaac aacaaagtca tatattgttt cagaatttag caaatgatcc 2032441 aaacttttaa atttaacttg gagttttaat agtagttctt ttattttctc ctcatcagat 2032501 actaagctga gaagatttaa gtacttggat aatgtgaaag acatgaccga ctctttattc 2032561 attcggataa tatcagctat atcagcatat gtaagtatat ctgacaagta ttcctctttt 2032621 ttctgttgtg tataattgga tctaagttca ataaaactcc aaaaatcatc ccatttacta 2032681 gatatcgatt ggataaaggc agctttattt attgcccttt ctttaaaacc atctatgaat 2032741 gtaacagatt ctttacttcc atttgcaagt cgctcaatta tgctatcata ataattacgg 2032801 tattcagaat gatccattat atagtttaag agatgaaaat taagtacctc tatttgctta 2032861 aattcagcac caactaattt gctcattatt ttaccgatat tatccagctc aaagctgtaa 2032921 ggcaatgact cgtggttttt aatactaaat acaaatttaa tatcggaaag acttaaactt 2032981 tctggataga agtaagtgat gtaatggtta tacatttcat caatatatcc atgacgtagc 2033041 aggtaaacaa gtaatttttt ctcgtaaagc ttatcagaaa atacatcctt tgaattcatt 2033101 tttgtaatta atacttgtaa agattgcgct cttatttctt gcttttctct ctctaattcc 2033161 aatagttctt tcttgaattt ttggatttca tttttctcta tagccttgat ggcatcttct 2033221 ctttcaaagt agttcggttt ccgaccaaaa acagttgcaa tttctttaat tgtcgctgga 2033281 ccatttctat ttcttaaata acaatagata gtatccgcat tttttaactt ctcaaaaaac 2033341 cgatctttat tagatgtatt gcctctaaat acctcgccat ctatattaat atcataatta 2033401 gaattcaaat ttgatatttc taattcgctc aagtatataa aatttaattc agcaattgat 2033461 tttaaagact caacttctat attcgctaat ttcctctcta attgttgtat tttagcatta 2033521 attaatttta tttgttcctc aattataagt tgtttttttt gaaagatttc atataccaac 2033581 cctttgttat attgtaattt agaaaaatcc acaggataaa tatttttgta gattatcatt 2033641 gctaacattt tgttaggatc aagatcaatt gcacttagtt tttgttggta tataacaaat 2033701 tcattaaaaa tattctttaa tactctcatg tcatcaatgt aaattgttac atcctctaag 2033761 aaatgagtgt ttatcaaatc agaatatggt gaatgtttta ttttcttttt aagtatgtct 2033821 cctgaattag atgcattaat aattggtatt actgggataa taaaatcaaa aaattttgtg 2033881 cggtctctag ttaacttttc agtgtctgca tctccaaaaa tatcatcttt tatcgcatat 2033941 ataaaaacaa cacgtctatc tatttgttct gaattattta taagttcatt taattctctt 2034001 aatctttcaa aaatacctat attattaaag cgatctaagt cctcaaatat tacaacatta 2034061 tacttggagg cttcaaaaaa atataatatt tcatctaaat atttatcaaa tatagaagag 2034121 ttttcttccc ctgtattttt ttctaacgtt gtattagcaa ttgtaacctt attcaatttt 2034181 aagttggcac ggacaaaatg ataaattctt ttatatgcga gtagaggata tactataaag 2034241 aacagtgcta ataatatagt cagtcgtatt tgttgctgat cttcagtacc gagactcctt 2034301 gaaactaacg tctcagcata tattccttta agtgcatcag gtttaaaaag gtagatgcca 2034361 actataataa atgcaaaaaa gaaaatcaaa tttataatta tgctcttagt ccttatatgc 2034421 ttaattcttt taaacctaga aaagggaatg gttctatcgt gtacccggta tatcatttgt 2034481 tgcaagatgc ttttctctaa cttattctcc atatcatccg tatctgtgtt gaatgtagct 2034541 aaggatatat ttaagaaact atattccctg ctgtattgtt tttgaaaggt atttaatatg 2034601 ctactttttc cagacccgta gggaccagtt agggcgatat ttttcacttt tttattttct 2034661 aacccccaac ttagtgcttt agaatatttt ccatcagtgt cgacatcatt gctaggagaa 2034721 agatcttcaa aaaggctttc ttccttaaca ttaggttctt ttagtctaat cagaagtttc 2034781 tctaaccact gcacaaattt ttttttgatt tcccccaaaa aaaacaaatc ctttctaaac 2034841 tttcaggtgt aatacgaatt aataaaactg gagcaaagaa ctaaataaat gagtatgtag 2034901 caatgacaaa tcatttctct tccatctaat atagtccttt atcgccagtt gaaattcact 2034961 attaattgta acatgaaagg gcattaaaag tttctgaaaa aaagatgatc aataaacaac 2035021 acagcgccca attacaggac tgtttcatat ttaaattgaa tttttataag cattaattgc 2035081 ttcatttcgc agcagcatat tatctttgtt aaccatgcct aagttgtaag cttttttgat 2035141 aatatctaat acctgagaat ctaacgccga aagattaccg cctggattaa atcttgattt 2035201 ccaataatct aaagaattat ttaggtcaag tgagcttttt ttgttctcgg gtttaactac 2035261 ttcatttttc tcaagtgttt cacagaattc actaaaacca atggatctac tgggagctga 2035321 gttatttccc ccgtatcctt ctgtagccaa gctgcaaaat gctaagaatt ttggatcata 2035381 aataagatcg cttcagttta catttaccac tgataatcac aatcctctca aagcttttta 2035441 taattgtagc accttttcca tttttacaca tattaaatat cgacaatcat tcaaatgatt 2035501 taataattga atacaaaaaa gaacctgcat tttgcaagtt cctttcacgt tgtcaatata 2035561 ttgtgaattt ttaacgacaa gggcatttat gtatagtatg atatttcctg tacagtaagt 2035621 tttgctcact cgagggagtc ttgctcatcc cctaatgaaa ggggtgatgc tatgtcaaca 2035681 ttccaggcat taatgctaat gcttgcaatc gggtcgttta taatcgccct attgacgtat 2035741 atagaaaaaa tagacctccc ttgagcctca gaacctgaag ggataggcct acctagaacc 2035801 acatcgagca agccctttga tgggcaactt tttgtacaga gccggggtgt tggtagcacc 2035861 tcggtctttt ttattttatg catttctcat taaagaaatg cactgtaatg tattgtaaaa 2035921 ctgattataa cacattttcc gtgaaatgca ttacaataaa cctcaagaga cttggaaagc 2035981 ttttttattg tttcttgtaa cgttataatg atctaaaata gcgcacaagc ctttatacat 2036041 cttcatcatt tcttactctt ctagctcgtc tttcaacatt ccaattccca atctttcccc 2036101 agacattctt gttagtccat ttccctagct tagttttatc aaaccattcc tgaaacaaag 2036161 atatttcatc tttcctttgc attgtatctt ttaaaaggaa ataatgtatt atccaaaaga 2036221 tataaagagc tgaacaagaa agtccaaaaa taagtttatt tacctctaac caatttccta 2036281 aaacttgttc gcctaaatat ttatcatata gaaggggtat aaaagcaaat gctgaagcac 2036341 cgacaaaaaa agctagagtt tctttaaacc atctaacaaa aacaaaaaca gcgcttaaaa 2036401 tataattcgt tctaaaaaga actttatacc aattataatt cttgtttaga gtaacaaata 2036461 tacttctata ttctttatta actgcttgat ctaacattct cattttataa aataattttt 2036521 tcctattctc gctgttcttg tttaaaatat actctctgaa acaatcttct gtattcaaaa 2036581 tttgatctat caataagatg tttctaagtt ttgatagctt cccctttttc ccactatatt 2036641 cttcgaaaaa tttttctata aggaccattt tatggttttc atcttcttca ttctttattt 2036701 cttttaggga ataatacata ggctctaaaa ttttttctaa tgtttcacct gattgagagt 2036761 agaatcgttc tatacttttt tgtctttgat tgaatagcaa tgcaactata cccgtaatta 2036821 ctgcagtaag aataccattt tgttgtatcc aattccaaat atctaataac tccaattaag 2036881 cttctcccct tctctctgaa tttactttta atacgggcta aaataaaaaa ggtttcatat 2036941 aaaacgggac tagaaaactt ctgtcacttt aattatttaa tccaataaaa taagctctca 2037001 ttgcgagagc ttattttatt tagattgagg atgtgcaact caagccttct attgcgctat 2037061 agcaatactt ttgcttaatc gtcccagtct tcatcctcat cccagtcatc tttcgcttcc 2037121 tgaatcttat tataaaaaaa ttcaataaag ctgtctgcaa cagtatcttg ataaccaatt 2037181 accctatccc attcaactac agggcattct ccgtctttca ttttatttgt atctagacag 2037241 taagcaaagt aatcaacatc ttcaataacc acaagtccat cagtaaggcc atagtgttct 2037301 ttatattcat tagttctatt tacaactgat gcatgatcaa agttgtagcc taaaaccaaa 2037361 acgccgaata aaccaccagc accgtatttt tctaaaaacc atttataact gttggggaga 2037421 tcgcattgga ggttttcttc aatgcgacca atgttttcat gacttgcacc ttctgtaaat 2037481 atagcatttt gtttattttc attaataaag ttctcaacct tcgaataaat catataaaca 2037541 cctcaattct cattttcaaa ttgtttcgct ctccatttcc aatatctctt tctaaagctc 2037601 tcgtattgtg cttttaaaac cttatcattt ctaaaacttt caccatcaga cttaagctga 2037661 tgaatgacat cactatattt tgtatgtaag ctgttcggga tttcaagcat tgggccaggt 2037721 tcttcttgaa tcaagtgatg taaattaatc tgtgtaccgt cttttgcata aggggcattc 2037781 ccgtttttca ttagctgaag atttgtaaca ccgaattctg ttttttgatt aatatcaata 2037841 tctttcatag tatacactct acggcttaca tctttaactt tccccttcgc ctttaccttc 2037901 ccctctattt catatgcatc atacttttct ttatttagcc aaggagggct tttcttttgg 2037961 ccagtaaacg gttttcttgt tccatccggt attttcttcg cattagtcaa aagttcattc 2038021 ttaaggtttt ggctatcaac cacattgtat ggcacgttat ctgctagagc aagcttatac 2038081 ttagggttgt aaggcagcaa atctggaatc ttaacgtcct tgattttctt acctgcttga 2038141 cttgctttat ttattacctt gcccgctgca tctgctttgt taatggctcc tgcacctttt 2038201 gtaccaacaa cagctacagc cactgaacca atagcatagg taacccatct tgatctagaa 2038261 taggcatctc cattcaccat atccttttga tatgactctt ctattgctgc tgaaatggca 2038321 tcgtatgttt tcactggatg catagctgca ttacccagtg ctgagagtgt ttctcctgga 2038381 tcggtgatga agtcccatat gccggttaca gtgtcttttc ctacatcgta taaaccaact 2038441 cctacacctt ttacgatatc ccaggtgatt tctcctgctc cttctagctg cttcgcttgt 2038501 tcaatttgca ctgcaagctg cacttgagtt ggctccagat tctcgtaccc tactttctta 2038561 gcaatctcta aatattcatc agggtcagat acaccgtcat taagtttttt ctttaattcc 2038621 ttgatttcac gttcctttgc ttcttctttc ttcacactta agtaagcttc agaatgcttt 2038681 tcaatatcgc cttttttctt atgtatgtca ctttctctgt acgctttagc gttatagtga 2038741 attggtgtag cgttttttcc tttgcctgtt gattcctgca gctttttaaa gtcttgctga 2038801 ataaattgtt cgtttggttc tgtttcagcg tattctgttt ttaaatcctc atcaagcttg 2038861 tttagcttat cgattgtttt ttcacgtttg tcatctgcag aagaaagttt gtctttgaag 2038921 tcttctgttg agaatatttc aaggggaagg atatcattga tgttgtttaa tatgtctttc 2038981 attgcttttt tctgttcaga cataatggat tttgattttg cataagcgtt agccaactcg 2039041 tgttctagaa aggattcttc tatgtaagca tcagacatct tcgcatcttc aagtgttgca 2039101 gacatgctgc ttaagaaagc aatcttcata tcgataagat caatccattg gtctgttacg 2039161 ccgacatgac catgataaaa tgctttaatg ttgtcagcac ccttgcctga aaattcactg 2039221 tcatctaggt tagctacttc cttaaacgct tttttgagct tcaccatttg cgaccttagt 2039281 tccttatact ctttggttct tttatccgct tcaaagagta atgaatcagc ctcaaatacc 2039341 ttcatatcat tctccttcct agactacttc tatgtaaatt ttaccacagt aatctaattg 2039401 aataacagaa aaagacagcc aaaatgactg tcttatacat cacacactat cttgttctat 2039461 aataattttc tgcggtatag tagcgccaat cccaaaaagg ttccccattg gccaatatat 2039521 accggtctaa aaatttttca aagtttaaat ttaatggatt atattctaaa ccactttcaa 2039581 atatatagag atagttggga tcaccttggt tcactttatc tttatcgatc attaaatggc 2039641 attcttccaa taagtagcca attggaatac cattgatatc ttcaaacaaa tcttcatatt 2039701 ttaactcctc ttcaatctct tcaaggctaa atagctgaag tcctccacct atattctccc 2039761 catcagaaag aatctcaaaa attttcgcac cgttatgtag tgtcatgaac ttctgataat 2039821 cctgtggaag ggtaagctgg tgtttagcct caaagctttg aatgtcattc agggttgctt 2039881 tgtcctgtga aaaagtaaca aggaactcca tgatatcacc ttctgaacaa aacaatttaa 2039941 tggctccttt ttcgtctaaa agacttttca agccatttac agtcttatga acaaagttag 2040001 tcacatacat caccccttta tttcctttta acaataacct ttcaaattcc aaaagatgtg 2040061 aacagatcgt gataggtgct cttttcagtg aatataatgc aataaattct aaaaagaggt 2040121 gcctccaaaa attgaattct ctaatgaatg atgacatggt aaagatcatt agaaatggcc 2040181 ttagcgcatc gcagcatcca aagcacattc ttgttatagg agctggattg tccgggcttg 2040241 tatcagcatc tttgttgaaa aatgccggtc acagagtaac gattctcgaa gcgagcggca 2040301 gagcgggcgg ccgtgtctgc actttgagat ctccctttag tgatgatttg tatttcaacg 2040361 ctggcccgat gcgcataccg aataaccatt cgttaacctt agaatatatc aaaaaattca 2040421 aattgccaac aaatgtattt atcaacagaa ccccgatgga catcatttat gcaaatggaa 2040481 tcaaaacacg tctccaagtt tttgaacgag ctcctggaat attgagatat ccagttgcac 2040541 caaatgaaca agggaaaacg tctgaagagc tgatgctttc tttactgcag cctattctaa 2040601 attttatcaa tcaaaatcca gcaagaaatt ggcggattgt cgaagaacaa tacaaaaatc 2040661 attcgttaag ctctttttta aacacgtatt tttcatatgg cgcgatcgat atgatcggtg 2040721 tacttttgga tatggaagcg tatatgggga tgtcccttgt tgaagtattg cgggaatcta 2040781 tctttttttc atcccccgct cacttctatg agataactgg cggtatggat ctgctgcctc 2040841 acgcgtttct tcctcaatta aaaacaaaca ttctatacca tcaaaaaatg atgaaaatgt 2040901 ctcagggtga aaatcgtgtt acgatccatt gtcagcatca acaaacggca gaattcacat 2040961 cattcacagc tgatctcgct attgtaacca ttcctttttc aacattgcga tttgtaaaag 2041021 tcgaaccata ccattcattc tcttactata aacggagggc catccgtgag ctaaactata 2041081 tcagtgcaac aaaaatcggc atagagttta aaagccgatt ttgggaaaaa gccggtcagc 2041141 acggcggcaa atctattact gatcttccga ttcgtttttc atattatcca agcagaaata 2041201 ttggagcaaa tggacatgct gtcattctgg ccagctatac atgggccgat gaggcactga 2041261 tatgggacag tctttcagaa ggagagcgaa tccagtatac tttactgaat ttatctgaaa 2041321 tctatggtga tattgtgtgg tctgaatttg tgtctggcac ttcttttagc tggagccagt 2041381 acccgtattc tgcgggaggt tttacagctt tcgaaccagg acaagaatta gagctgtatc 2041441 cctatattcc tgtccctgag ggcagagttc atttcgccgg agaacacgcc tcactcactc 2041501 atgcgtggat gcaaggcgcg attgaatctg gaatacgtgt tgcttatgag gtcaatcgct 2041561 taccttagat catgctcaca tcttgttaaa actggttgat ataaaaagaa gtgaagaatt 2041621 tatactcctt tgtttaaaag attaattcaa atatgggatg tctcaacatt cggttcttta 2041681 ttatctttat acacgttttg aatgcggacc tcccttttct tccataatca ttaataaata 2041741 cccaaccata ggaaacgttt taattaacca tcgggcgaac tttctttcac tgtataacga 2041801 ttcttaatgt tgctttttat cctttacttg tcctctcttt ttttcattga cttacatttc 2041861 ttgaaaacca gtataaatcc taaaggaatt ttgtaacaaa tacagaattg gaaagagaag 2041921 cgccaaaaga aatgctaact ccttatctca aagacaaaac tgcgcttata ttaaaagaaa 2041981 gaggtgtctt tagaatggtt cattttaaaa actgccctga tccttctcta aacgccaatt 2042041 ctcagtctca ccccgaattt tcatccgaat tagaacatat taagacaaga atgcaaaact 2042101 ttattaagca ctcggttaca gaccaaaata tcgaagttac tgacgcaagg gtgacggccg 2042161 aaggagaggt cacctctctt ttaaaagaac gtctcgacaa ggaatattat aggcttttat 2042221 ctaaaatcac ccgggaagta aatgtggctg acttcggcgc tgttccagat ggaagagaca 2042281 atactgaagc ttttcgaaaa gcaatcggga atggccgagt caaagtacat gttccagcgg 2042341 gagaatacct cgttcaaggg attaaacttc catcttggac aacaattgtt ggacaaggta 2042401 aagggatcac agtgattaaa ttgcatgaag acactccagc gcatgaatgg gtgattacaa 2042461 atgatgatta tcaaaatgga aatcgcaata tttttgtcca aggaatgtca ttagactgga 2042521 atccaagtag acaatgcggt gtgagaaatc cagggggaca gttctccagt tgtttaactt 2042581 ttgctaaggt tgaatatggg tggatcaaag atgtggaagc gattaacgca ggtcttcatg 2042641 gtattgatat tacatcgcca acgtatgacc atttgcctga taccgattgg acaaaagacg 2042701 gatcaagata tatttggatc gataactgtg tgacatatgg ttcaggagac gacggcatta 2042761 ccacccatta tagcgaatac atctttattt caaactgcca ttcaggaaat ccgcggggaa 2042821 cagaatttgc tgaaggtgtt tcaaactcca acggaataga aattgacgac ggctctaggc 2042881 atgtgtggct tttgaataac tttacaagcg gcaacatccg cggagttgaa gtaaaagccc 2042941 atgaactgtg gccagcctct caaaacgtcc atatcatagg ccatatttct tatcgcgatg 2043001 ttcgtgcatt tgatcttcgt catattggtc accatcaaat tacagatcct gaaagcacaa 2043061 cagcatacga tgtcacactc attgattgtt cagcagttga accagttttc aactcgcttt 2043121 acgatgctgt gaccccaaga gcgctggtta tttcggcata taaaaacgtt aatgtaagcg 2043181 gattcacagc gattggtgat ccagactatg attataaaga aaaccctgtc gtagccttgc 2043241 aatatcgcag ccaaaatata accattaatg gtattaaaat tcgcggtttt aaaaaagccg 2043301 gtgttgatat taatttatca ggcggatcaa ataaaactga ttatattaaa atttcaaatt 2043361 ttgatattta taaatctgct ccaaaaggaa tttcaatcgg tggaggcctc tacaatgtca 2043421 atattctaaa tggaacgatg attactgaca atgggacagt tgcaattcag tcccccaata 2043481 atcaggccac aattctcggt gtacaatcag aaggttatag tgtggcagcc tcaatcaaag 2043541 gccaaacata ccaacaagtt ccaatcaatt tgaaaggagg catacagctt gcaacgacct 2043601 ctggctttgc cgttaaccaa acaagcgcag ttatagcagg taccggcgac attacggccc 2043661 gcggagaaag aaatgcggtc attagctctt ctggaggctc cagtactgaa ggctctcgcg 2043721 cattaatcgc ttcttcaaat aacgcacata ttagaggaaa ccaagcgtca agaacaatac 2043781 tgtcttctga aaatattata cttgaggaac catacaccgt ggcaggaggt catcaatcaa 2043841 taaagtggct tcttgactct gttcggggaa acgggacgtt tgccggtgca atcagttctt 2043901 ctttaggtgg atatggagag tattttgaga gttcaactgg acagttaatc catactggta 2043961 caatcgtgac tttaagaggt gaaaaaattg tgcccgcgaa tgttggagat tatatgcttg 2044021 gcgttatttc agaaacttca gctttcattt caggagcctc cagtttcgtc tggcagggcc 2044081 gttatttgac aaatgagttc ggcggattta tttatgaaac ggtgactgat gaggaaagcg 2044141 gtgaactcat acgtgttccc aaacaaaatc cagactacga tacagcgctg gaggcaaatt 2044201 atcattcacg ggcagcaaga gacgaatggc acgttgtagg gttggttggc caacattatg 2044261 tgcgtattga cgaaactgtc aatcaaggag attatcttac ggcacataat ggaataggaa 2044321 caaaagccac tgaaggaagc tggaaagtaa tgaaaataac ctctgcttac acatcagaaa 2044381 aagggtatgg tatcgctcta accgtcatca aatagtggat acgccgacca gttcaatata 2044441 tgtttatcca aataattaga tctcttttct aggttcttta ttccttgtat gttattatca 2044501 attttcaata tctaccaaaa tacccctaat atactatcgt aattaactta tattataatc 2044561 aaaaaaattt tgacagctgt tccttctcgt tattcatgaa agttgctatt gaaatgagta 2044621 aatggatatc atattagact tctatagcaa atacaccata tatatccttt aagtatttac 2044681 aaattgaaaa tgtttcatga ggcttattaa aagtattgtt cttttatcat ctgtaagtcg 2044741 atacaaactg cattaagatc acacctaaat ctcactgagt tttttcttac aaataaaatg 2044801 aaaacccttt ccattctaaa ttcatttcac cgttactaaa agtaatcctt gcattccttc 2044861 gccctccatg ctatattcat atagcgatga gctgaattgt gtaagccgat gtacatgcct 2044921 ttacggcaca cacgaatgtg gcgtgtggtg catcgcctca atacgcaaag acgtttgcct 2044981 taggcaaacg tctttttttg cgttatccga tttttgtgcc gtttgggaca ggctgatccg 2045041 gctgcaaaag gacgacgtcg ccctggccgg gtatgccgcc gaggaccaag acttccgatt 2045101 taaatccggc gatccggcgg ggcggaaagt tcacgactgc tatgacttgc ttgttgatga 2045161 gaccttccgg cttgtaacgc ttcgtgattt gtgcgctcga ttgttttatg ccgatttcag 2045221 tcccaaaatc tatcacaagc ttgattgccg gtactcttgc ttcaggaaat tcttccgctt 2045281 ttacaattgt tcccgttctg atatccaatt tctcaaagtc atcaataact gccatatcaa 2045341 taactccttt ttctcctatt gtaaaggaga tatacaatat tcttttaact aaagagccat 2045401 cattttttat ccgaatataa ggtgtttcga tacaggcggg gcggcattcc tgtgcttttc 2045461 gtgaaccatc ttgtaaaaga agaaaggttt tgaaagccca gcgcctcgct cacgacggta 2045521 agagtttcat ttctctccat cagcattctt tttgcttcct caaggcgaag gtcggcaata 2045581 tagttctgcg gggacttccc tgtctgtttt ttgaaccagc ttgaatagta agctgggtga 2045641 taatgctcga tttctgccag cttcttaatc gtcagccgct caaataaatg gctgtgaatg 2045701 tatgcaattg aggcatagct atgggattga agcttttctt ttatgtattg tactagcata 2045761 tgaagcgagt tggctgttcc ggcctttgct tcctctgtca gcaagtacct gatcgaagac 2045821 cagaaaggat cgagggcagc ttcaattcct gatcctgcac gatactcatc aattttcatt 2045881 gcatgaagcg gaacatccag tacaagacat tcatttcttc cgatagaacg gaagcgatgc 2045941 tcgcactgcg gcggaatata taaaaaatga tccggattta atttcacctg gcgcccctca 2046001 gtctcaagat caatactccc ttcaagcgga aaaagaaatt ggctgtacgc gtgcttatgt 2046061 gaatgatata gccgtgtgta tgtccgtttt tcgcaaatta tctcttgaag cgagtccatt 2046121 agcaaacccc ttcctttggt catcttttaa tccggtaatg gtgttccgat ataggcgaaa 2046181 agccgatttt tccatataaa gaaactgccg ccagattttc tttcatcact tgtaaaaaca 2046241 tgcgttccgc tccgttgttt tttgcccatt cagtcaacac cctgatcact tgggttcctg 2046301 ccccttttcc tctgtgctcc tcagctacaa cgatattact aagtccgcca taaccatcaa 2046361 tgacagaaac cgtgccaagc gctgtcaggc tttctttgtc atacatcttg aaaaaagttt 2046421 tacacggcgg catgcgttcg aatatgtgtt tgtaaccttt gtgacgctcg ggtgaaaacc 2046481 cttctaattg aataaattca tctatccaaa cagatgatgg ctcttgttcc cacttgtatg 2046541 taaatcggct gttgtcattt gttcggctca taattgaccg gcacaacgct gtcatctgga 2046601 agcactcgtc taccttttca taacggctgt ctgccaatgc gtcatcaagc cctttcggtg 2046661 atgcgttgct aatatgaaaa caaacaggta agcctaaact ttgataaaaa agttcggcct 2046721 ctagctgaaa atccccttca ggcatatccg cagacgtcca tacgctattt gcccttttgg 2046781 ttacgccaaa attcgctctg agaagccatt tccctatgct tttttgaaaa taagccggcc 2046841 atgaagctgc cgctaatcgt tcaatcttgc gaatgtcatc cattgcataa tgcctctccc 2046901 ctatgtatac tcccttgata ttatacaata ttcagaaata taagacatcc atttatttgt 2046961 ttacataata tttttattgt ttattaataa tcctgacaaa aatgtccgaa ttgaaaatga 2047021 caggctttct aaaatgtcct cctcacgttc aaatgcttct tttgcgatta aaacagtaaa 2047081 gccatgcagc agacttctga gcccccttgt cgcatgaatg gcagtctttt cacttgcata 2047141 gccgttttca atgagcagct tcgtcacaag acagacaatt tggtcagaga cgatttccgt 2047201 ccgtttgtcg tgaaccttaa gaagagccgc ttcataatat ccgggatttt caattgcaaa 2047261 atcaacatat gcatgagcta aagaaagcat cgcggaatct ccctttcgtt cggttacgga 2047321 gtccgccatt tgatcaaaaa gctttgtcag tcctctgaca gcaagttctg ctctgatcgc 2047381 ttgcagcccg ttgatatggt tatacaatga cggggggcga acattcattt ttttagaaag 2047441 tgcagcaagt gagacaccat ttaccccttc ctgatcggca atctctgctg cagcgtctac 2047501 aatcattttt tgggtcaaac ctattctcgg tgacatgctc atcatccttt ctttgctttt 2047561 tggatcgcct gtctcatccg ctctgaaggt gatcgcagga attttccatg tccgacagcg 2047621 agacaggaag gcgccttatc ggcgagcaat tgtgcacttt tgatggcctc ctccttattc 2047681 catgtggcga aagcgggaaa aggaaacgcc cattttatct gacctgatac agcgattcct 2047741 ccgcgcaact gaaacgcatc tcctgctatt aaagtgccgt ttcttgtatc aagaaatgac 2047801 atgctgcccg gtgtatggcc cggtgttgga atggcaagca gagaaccaat tgtttcaccg 2047861 cccgtcagca gttggtgagg ctttgtttgt atgtgtttcg gaatacctcc ttttataggc 2047921 gtctgcggct catcttgccg caaagatgtg tcaccttgga gcaagaatga atcccgttcc 2047981 gagatcatga cctttgcatg cggaaatgtt tgtgccaatg tatccagtga tccgacatgg 2048041 tccccatgtg catgagtcag taaaatatgc tgaagcggtt ttccaagctg attcacagct 2048101 tgaataatcc ctttatagct gcctggcagt gcggcatcaa taagggtgac ttcgttttct 2048161 tcctctacta aatagcaatt aaccggaaac aatgctggaa aaaaagtcag ctgccaaacc 2048221 gtttggtact gagtaattct catcttttta ttcctcctaa caaaaactaa tggtgttagt 2048281 tttattatta actaacacca ttagtttttc aagagtttat tattttttta tcgctacata 2048341 aatgttaact tgtgctcgct gtggcactgc ggcattttga tcatacatct caaagtcacc 2048401 tgtaaacgtg cgcagatgcc gcttatccca agtccaaatt tccttccacg tttcaagcac 2048461 aatctcttca ataggaccga ttctggaagt gaaaacggcg taagcggaag ccggcaaatc 2048521 aatattttca tatggtcccg gaagaatgtc gtcgtattcc tgaaacgttc cgactgaaaa 2048581 cgtataaaac ccattcgtct cttgttcata attcgaatat aaggcaataa tgctcttgtc 2048641 tttttcagcc tgtgataaaa gagcgctcat atcctgcttc cataattgat cccacagtgc 2048701 cggaatcctc ctttcttccg tcatttccag tgcgttgctt gtccgttgtg atagtccggc 2048761 aaatcgtttc aggtctaagt gtgttatatg tgaaaagccc atacgatctc ctcctttttt 2048821 taagattata gacaaagaaa cctgacagca gtgtgtcagg tttcatatat tttttgcatg 2048881 tgatgaatgg tttcttttac tttatccctt atatgaagag gctgcagaac ctcaatatcc 2048941 tttccgaact ggagcaaaaa accgatcagc cattgatctt ctggaagtga aatcaccgcc 2049001 tggcagattt catcttcctc acaacagtga aggacatcat atccgaacca ttcacctata 2049061 cgctgacgtg ctgacggctg aacaagaata accaattcag ttaaacggtc cttttggtac 2049121 caactcttat cccatggcaa agtgtccagc tgaatgtctt ttctgataaa tgtctgatgt 2049181 aagatggcca gatctttcat ccggttcagt ttaaaaaagc gaaaatcatt tcttaccagg 2049241 cagtaggcat ataaatacca gtgccccgcc ttgcaaacca atgtataagg ttcagtttcc 2049301 cgaagtagtg tttccccgct tgcgcttgta tatgtaaaag atatcgttaa caaccgatcg 2049361 atggcagcgc tgattttctc gcgcagcgtc ttttgatcct cagtatggcc ccaagccgtc 2049421 atgtcaataa accatttttc tgtttggtgc ttaaatgctt gagtagattg ctcaggtata 2049481 aggtgtttga ttttttgata ggctgtgctg tgagaaacgg gttcatacat agatgaaacg 2049541 ctttgcaaag cggaagcaat tgcaaacaat tcctcctcct tcagccactc tctttcaagc 2049601 cgatacgttt ccatgatgcc aattccgccc ccggaaccct gtgaggtcac aatcggaata 2049661 ccagccctat tgatcgtctc aatatcacgg taaattgttc tgacagatac ttcaaacagc 2049721 tcagcaagct ctgcagcctg cacttgtttt ttgctgatca ataacacaac catcgctaac 2049781 aaacgttcca gtttcattct gcgcaccttt tcttcttgta ttttccaaca aaacaatcat 2049841 aacattttga taaagcttgg gcatatctat tatgcggcgg aatacacctc gcatatgcta 2049901 tgaaaacagg ggtttcccct tcttttttgt gttcagtatt tatttcagct actatttccg 2049961 accggataag catacacttc tcaacggagg ggatttcaca tcatgcatct tacacttcag 2050021 agcgtttatc ctgccataat catcatcttt tttctgtata aaaaaattaa aaggtccatc 2050081 ggataccagc cgctgaagcc ccgctggctg ttcacccgta tcattctttt ctcgctgttt 2050141 gcttttggac tttcaatctt cagcgccatt cacccttttt tatatggata tctcattttg 2050201 ggcattcttg gcggatggct ccttgtcttt ttcgctaaga aaaacatctc ttttgaaaaa 2050261 cgcagaggaa agatctattt tcggactcat atttgggtag aggtgattct cttaacttta 2050321 tttctatcaa gatttctgta tcgagtgacg gagctttatc ttacctcacc tgatctaaac 2050381 cgccttggat catacagtca gtcaatcgga acggaccctc tgacaattgg cgtctgtttt 2050441 ctgatagccg tttattatat cggtttttct tcttttatca tcaagctcag cagaaacgaa 2050501 cttgaacagc acgaatacaa taaagaaaaa gacatccttg cccgctaaca gcgagttaag 2050561 caaggatgtc tttttcaatc atgctgtgta tgatggatca tttgctgaag aacatctaaa 2050621 acatgttcat cctccggaga gtaataaatc gatgttcctt ctctgcgcga tttgacaagc 2050681 cggagatttt ttaaaaatct aagctggtgg gacacagtgg attgcagtaa attcagcttt 2050741 tctgcaattc cgtttactgc atgctcacct tgggacaata aatggagaat tctgattcgg 2050801 gtaggatctg aaagcgcttt gaatgtttgc gcgactagaa acagcgtctc ctcgtccaga 2050861 tcagcagccg attgttccgt ttctctaaat tcagtcatat gtatcacctt tctttattca 2050921 tagttttatc ttataacaaa tgcgcttgag tgcaaaccag cctgcttgta ttccatttca 2050981 atctcatagt ttaaatttat gtttcaaatc aggtttttac ttggtctgat ataccctctt 2051041 atgtcataat aaaaaaggtc atactgctcc aaacattgag ggtgaaacac agtgaagaaa 2051101 aagagaaaag gctgtttcgc tgctgcgggt tttatgatga tttttgtctt tgtcatcgcc 2051161 tcttttttat tggtcctgct ttttttcaac cgggatttaa tcaaaaaact tccgatcgat 2051221 acgaaaacga ttgttttgga acgtttaacc gattacaaac ccttggtgga agaagagctt 2051281 gaaagccaag gactctctaa ttatacatca ctcatattag gcatgatgta tcaggagtca 2051341 aaaggaaaag gcaatgatcc catgcagtcc tctgaatctc tggggttaaa acgcaatgag 2051401 ataacagacc ctcaactcag tgttaaacaa ggcatcaagc aatttaccct catgtacaag 2051461 accggtaagg aaaaaggcgt ggatttggat accattattc aaagctacaa catgggggca 2051521 ggttacattg attttgtagc tgaacatgga ggaacgcata ctgaggaatt ggcaaaacaa 2051581 tactccgagc agcaagtcaa aaaaaatcct gatctgtata cttgcggggg aaatgcgaaa 2051641 aatttccgct atccgtattg ctacggtgat tatacgtatg cagaaaaagt aaaagaaaaa 2051701 acaaaaactg ttgaagaatc tttgcaggtt gcaacacttg aaaccatgga atccaaggct 2051761 catgaataag agtctatcaa tttactgaca aaagcccaaa aatgaatttg ggcttttgcc 2051821 atgtttacac gtaaaaaaag ccatactgag tatggctttt aataatacgg tgaaatcatc 2051881 aaatatacaa taacgcctgt aaggcttaca tacagccata gaggcattgt ccatctcgca 2051941 atttttttat ggcgctccac ctgcatgctg aagcctctga tcagcgtaaa cagcgcaagc 2052001 ggcacaataa ttgcagaaag gcagatatgt gtaattaaaa taaagaaata aatcgggcgc 2052061 ataatacctt ctccgccata gagcgtgttt tccgcaatcg agtggtacgt cacatagcaa 2052121 atcaaaaata gtaatgttgt tgtgaacgca gccaaaataa agcgtttgtg agctttgata 2052181 tttttctgtt taatcataat cagcgcggcc aataagaaga taaacgtaaa gctattgaat 2052241 atcgcattca gcattggcaa aatgtgaata ttcgcatggc tgaactgatc taatttaggc 2052301 ataaaaaaca gcactgcgat taaaccgtta atcagaactg tcagcgtaag gacaatcccc 2052361 gtgtaatttt tcggtttatt ttctgtttgg ttcatttggt gacctctcct aatttgtact 2052421 ggctatccaa atcgtatgca aattcaaaga agatgtcaac ggtttcgatt gcttcgtcag 2052481 aaattagaca cacttcaaag gccggaggct attagccccg gcctgttagg tttacgcctc 2052541 ttttatcaaa tgttcaatga ccttatgttc attttcattc agcaggttct tttgaatttt 2052601 cgaatgaatg ggtttattca tatgctgatc caagatatcg gccgtttctt tatccccggc 2052661 aataaccatt cgttcccatc ttttcgcggc agctttttga tcaaggctgg cagccagccg 2052721 cttatacagt ctcgattggt tctctgttac atgttccctc atccggttct cttcaaatgg 2052781 tggcgctttg tctacagcgg aatggctatt cttccaagac tcattgatca tatcatactc 2052841 ataacgctcc accgcctcaa tttttcctaa aacagtttca ataattttca cttcatgctg 2052901 ctgagttaaa ataaacgccg tacttgggta tgtctggcgc aaacccttta gctgatccag 2052961 gacagctgtt tcttcccagt aaaatcttgt atctacaggg acttgaagct taataggttc 2053021 ccatatgccg ctgtcggaaa caaaaaacac gagactgcgg ggcatgtctt ttcccattgc 2053081 attcaagtat tgattcattt tagccctgat tccatccaga cacttttcct cctctggatc 2053141 actagctgcc aaatactctt ttaatcggct gaatcctgac tttagggcaa tcttccattc 2053201 tcccccctgc tgctctggat ctctcatgtc tgtattgaga tacagagaga gaattttatc 2053261 cggcggttcc aattggacat actgtaattt gttaatcaat gaatcaatcg ccattccgat 2053321 tcctcctttt tcacaggtta gttttctttt tcctctctta aaaacgatca aacctgactt 2053381 tccgctaatt tctagtaata atggaattgt tgtttacaat acgcctctct tctaatacaa 2053441 ttggtaactg tgtttctaag ctgttttttg aaaggagttt gatcttgttt actgttaaag 2053501 aaaaaaatcg tcaagagctt gaggaagaac taaatgattt agaatttcaa atttatcgca 2053561 tgcaggagaa tatgaaggat ttatctaaag atgccaaagt gcttggtatt gatcaatcga 2053621 aacatgatga gtggatgatt gtttcctcga ttgatgatgg ccaaacatgc aaaattatgc 2053681 taactgattg taaaacggca taccgaggaa aaggctgttt ttcacttgta gcgtcttaca 2053741 aggacgatgc cattcatata ggggatataa aaggccctcc gaatcacggg tttggctcca 2053801 tttgcatgaa atatttaaaa gatattgcaa gagaccataa tataccgaaa gtcaccggag 2053861 acatcgccaa acgggattgg aatcatgtag accggctgat tcacttttat gaaaaacatc 2053921 acttcaaagt atgtatcgat catgataccc aatccggcag cattaagtgg gttgatttgt 2053981 aaaaaagtct ggaagaaaga gccaagatat gctgtaatgg tataaaacca ttgatggagg 2054041 gttctatgta cgcctcaaaa ctgaaaaagg gagacgaaat ccggatcgtg tctcccgcga 2054101 ccagcatgtc tatattatca aatgaagcaa aaatccaagc aaaaacggcg ttagaacgct 2054161 taggttatcg ggtaaccatc gctgaacacg caaatgaatg taacgaattt gattcatcct 2054221 ctatcgagtc aagagtccat gatctgcacg ctgccttttt tgatccaggc gtcaaagcga 2054281 ttttaacgac actcggaggg tttaattcaa atcagctgct gcgttatctt gattacgaga 2054341 aaatcaaacg acatccaaaa attctgtgcg gttattccga tataaccgct ctttgcaacg 2054401 ctatttatca aaaaacgggt cttgttacgt attcaggtcc ccacttctca acatttgcaa 2054461 tgaaaaaagg actcgattat acagaggagt attttctttc ttgctgcgct tcagacgatc 2054521 cgtttgaaat tcacccctca agtgagtgga gcgatgatcg ctggtttttg gatcaagaaa 2054581 acaggcgttt ttatcctaat aacggccctg ttgtaatcca agaaggttat gcggaaggta 2054641 ctttaattgg cggaaactta tgcacgctta atttgctgca gggaacggag tattttcccg 2054701 aaacagaaca tactatttta ttgattgaag atgattatat gtcagacatc catatgtttg 2054761 accgcgatct gcaatcactc atccacctcc ccgctttttc acatgtaaag gcgattttga 2054821 tcggcagatt tcagaaagca tcaaacgtat caatagatct tgtaaaagcc atgatcgaaa 2054881 caaaaaaaga attatccggc atcccgatca tcgcaaatat aaatgccgga catacctcgc 2054941 caattgccac gttccctata ggaggaacat gcaggattga agctatttcg ggtacatcac 2055001 gaatatggat tgataaacat taatcagctt gtaaattttt ttacaagctt ttttagcgca 2055061 atcggctatg catgccgcac gagacatgac aaatgtcata taggaggcat gatgtgtgct 2055121 actacaaaag acttctctca ttagcgtata ctgaaccgag acacacaatg agaggatact 2055181 tactatgact gaacaaacca ttgcacataa acaaaaacag ctgacaaagc aagtcgctgc 2055241 atttgctcag cctgaaacaa aaaacagcct gattcagctt ttaaacacgt ttatcccatt 2055301 cttcggccta tggtttcttg cttatctcag cctcgatgtc tcctatcttc ttacgttagc 2055361 attaacggtg attgccgcag gttttctgac aagaattttt atcatcttcc atgactgctg 2055421 ccatcaatct tttttcaaac aaaaacgcta taaccacatt ctcggttttc tgacaggtgt 2055481 cctgacttta ttcccgtatc ttcaatggca gcacagccat tcgattcatc atgcaactag 2055541 cagcaatctg gataaacgcg gaacaggaga catctggatg ttaacagtaa acgaatataa 2055601 agctgcatcc agacgaacaa agcttgcata cagactttat agaaacccgt ttatcatgtt 2055661 tattctcgga ccgatttatg tttttctgat cacgaaccgt tttaacaaaa aaggcgcaag 2055721 acgcaaggaa cgtgtaaaca cataccttac gaatctggca attgtcgcgt tggctgccgc 2055781 ttgctgtctg atctttggct ggcaatcgtt tttactggtg caaggcccga tatttctgat 2055841 ttcaggttca atcggtgttt ggctgtttta tgtgcagcat acctttgaag attcttattt 2055901 tgaagcggat gaaaactgga gctacgttca ggctgctgtt gaaggcagct cattttataa 2055961 actcccgaaa ctgcttcaat ggctaacagg caatattggt taccaccacg ttcatcattt 2056021 gagtccaaag gtgcctaact ataagcttga agttgctcat gaacatcacg aaccattaaa 2056081 aaacgtaccg acaatcacct taaaaacaag cctgcaatca cttgcgttcc gtctatggga 2056141 tgaagataac aaacagtttg tgtcatttcg ggctataaaa catatacctg taagccttcc 2056201 gcctgattca ccagaaaaac agaagctgcg gaagaatgcc tgatgataaa ggaggtcttc 2056261 taatatacta gaaggcttcc tttttattgt tggagggtgc attctggctt tcacaatgat 2056321 aaagttacaa gtaagatgaa aagctgaaaa tgaggtaaga tcatgattaa aaatcatttt 2056381 acatttcaaa aactaaacgg gattacgccc tatatatgga cgatattttt catcctcccc 2056441 ttctacttta tatggaaatc atcatctaca tttgttatta ttgtcggcat cattttgacg 2056501 cttttatttt tttcggtata tcgatttgct tttgtctcaa aaggctggac catttatttg 2056561 tggggatttt tattaattgg catttcaacc gcctccatta ctctgttcag ttatatttat 2056621 tttgctttct ttattgctta ttttattgga aacattaagg aacgcgtccc ttttcatatt 2056681 ttatattatg tccatttaat aagcgcggcc gtcgcagcca atttcagtct cgtattaaaa 2056741 aaggaattct ttctgacaca aattcctttt gtcgttatta ccctcatcag cgcaatttta 2056801 ttgcccttca gtataaaaag ccgcaaggag cgcgaacgac ttgaagaaaa gctcgaggat 2056861 gcaaatgaac ggattgcaga actggtaaaa ttagaagaac gtcagcgaat tgcccgcgat 2056921 ctccatgata cgcttgggca aaagctttct cttattggtt taaaaagcga cttagcaaga 2056981 aaattgatat acaaagatcc cgaacaagca gctcgtgaac tgaaaagtgt tcagcaaaca 2057041 gcgcgaactt ctttaaatga agtaagaaaa atcgtttcct ctatgaaggg catccggctc 2057101 aaggatgaat tgatcaacat caaacaaatt ctcgaagcag ctgacattat gtttatctat 2057161 gaagaagaga aatggcccga gaatatctca ttgctgaatg aaaacatttt gagcatgtgc 2057221 ttaaaggaag ctgtcacaaa tgtcgtcaaa cacagccagg ctaaaacttg ccgagttgac 2057281 attcagcagc tctggaagga agttgtgatt acagtgtctg acgatggaac attcaaagga 2057341 gaagaaaatt ccttttcaaa aggacatggc ttactcggga tgagagaacg gcttgagttt 2057401 gcaaacggaa gccttcacat cgataccgaa aacgggacca agcttaccat ggcaattcct 2057461 aataattcaa aataaacata aaggatggct tatatgatta gtatatttat tgcagaagat 2057521 cagcaaatgc tgctgggcgc tttaggatca cttctaaacc tcgaagacga tatggaagtc 2057581 gtaggcaaag gtacaaccgg ccaagatgct gttgattttg tcaaaaaacg ccagcctgat 2057641 gtatgtatta tggacattga aatgcccgga aaaacagggc ttgaagctgc tgaggagcta 2057701 aaagatacag gctgcaaaat tatcatctta accaccttcg ccagacccgg ttactttcag 2057761 agagctatta aagctggcgt taaaggctat ttgttaaaag acagtccgag tgaagagctg 2057821 gccaacgcca tccgtagcgt catgaacgga aaacgcatct atgcacctga actgatggag 2057881 gacttataca gcgaagctaa ccctcttaca gatagagaaa aagaagtgct cgaacttgtg 2057941 gctgacggta aaaacacaaa agaaatcgct caggaactca gcatcaaaag cgggacggtg 2058001 cggaattata tctcaatgat tctagaaaag cttgaagtga aaaatcgaat tgaagccatt 2058061 acccggtcaa aagaaaaagg ctggtttaaa taaaaaagga tcttggcatc tgccaggatc 2058121 ctttttgtta acctgaaatt cccgtttgag aacctcgtcg caaccagaat taaattgatc 2058181 catatcctcg ctcctacgcc cgctgaacga ttgtttggtt aacagcccaa taaaagactg 2058241 gattgaatga tatccctgtt aaaatggtcg gccattgcac atcagcagaa tttctgatat 2058301 tgattatatt gtattttcag tatgacaaag ttgtgccact tcgctcccga agctgccatg 2058361 cccaactgca agagcctaat atcacaataa aaaaccgtct gaaatcaatc cgattccgta 2058421 aatggtatct gctacatcca actgcttatt atctgccaaa aacaccagct cgtttcgctg 2058481 atcaaagata gtaacaacca gctataaatg tcatgatgcc gaatgtctct gtaatgtgga 2058541 atcaatcttt taacccgaga gcccctgaat cgcacataaa gaaaaacggg accactttct 2058601 tttatcagca tatgatataa acagctctaa gcagaacaaa aaaagacaca agccaaaagc 2058661 ttatgtcttt tatcacaatc tatattatta gtttaagact ttaacactta cagttttgac 2058721 gccccaatta gaagcatcac ttttacttgg tacaaatacg tcgattttat ttcctttaat 2058781 agcgccgcca gtgtctgctg ctgttgcttc cccgtagcct tcaacataga ctttagaacc 2058841 tagcggaatt acattaggat caaccgcaat aactttcgcg ttcgggttct tatttaagtc 2058901 aatgcctgta gctgtaacgc cggaaatgcc gccgtcgtta gcagtgtaag cagtagcagt 2058961 aactgttagt tcttttgaag cttcttgatt atttgtattt gattgaacag ccttctcctc 2059021 tgtgttaaca gaagtttctg cctcagcctt tgtttcttgt ttaggttgct gttgtacagc 2059081 ttcttgttta ggttgctctt tttgcacagc ctcttgtttt ggcgcagctt gaggtgcgtt 2059141 tgtttgcgca ttctcagtag ctgtgtttgc tgctgttgcc tgacctttta ctgaaagagt 2059201 tgatccagca tagatcatgt cagagcttaa gttattccaa actttcaggt tgttgactgt 2059261 cgtgccgaat ttttgagcaa tcttagaaag cgtatctccc gctttaattg tatattgccc 2059321 agtcgtggtt gtttcttctg aagaaatggt cagtttttct cctgcaatga ttttatcaga 2059381 agttaacttg ttccattctt ttaagtcctt taggttcact ccatttttct gagagattcc 2059441 ccagagcgta tcaccctttt gcaccgtaat ttcttttgca gaagcgtgag ctccgaatgc 2059501 agttgttgaa agtgcagcaa ctgccacaaa ggacataatc gtcttcttca taagtaaatc 2059561 ctcccttgtt agctttttat tggcggctaa caggtgatat cgtaacacac gtaaatgtca 2059621 aatcaataac aaaaagatat gatttagatt acagttcctt tacatgaagg atttctctct 2059681 gatggaaaga cttgctgaac ccttgatata ataggcttcg caggtctttt tattttgagg 2059741 cgaaacagag aaaataaaat gtgtttttta tagaaaaaaa gattgttttt ctgttttttt 2059801 agtctgtcat ccttgcataa gcctgtattt cttgtaaaaa aagccggccg tattttgctc 2059861 ttttttgttc tccgactcct tttatagaca aaagttcatc atcatttacg ggctgttttc 2059921 ctgacatttc ttttaacgtt tggtcagaga aaacaacaaa tggcggaaca ccctgctcag 2059981 ccgcaatttc tttccgaacc atgcgcaatc gttcaaatag ctcgtcattt tcagtaatcg 2060041 ctgccgcttt taacgcttct tttctcgcta ctgataattc tcctttcagc acattccttc 2060101 ctttactgct gacaaaaaga gtcggaaacg ttccgtctga catcctgatg aagtcgtcag 2060161 aaataagaaa ttcgataaaa tcactgattt cgccaacgga ttggtgtttt aatatcccgt 2060221 atgttgaaag gtcggaaaag ccgttttcaa gaactttttt atttttggag ccggcaagca 2060281 cctgggcaac catcgtcttg ccaaaccgtt ctttcatgcg aatgatacaa gataagacca 2060341 tttgcgcctc ccgcgtcacg tcatgggccg ctcttgtatc ggtacagttt ccgcactgtc 2060401 cgcacgcatc aggctccttt tctccgaaat acataaggat aaaacgctgc agacaatctt 2060461 ccgtatgaca gtagtcgacc atttgtctca gcttttttaa atcctgcttt tgtttctctt 2060521 catgttctga ttgctcaatt aagaagcgct gcaccataat atcctgcggt gaaaacagga 2060581 gaacacattc actggcaaga ccgtcccgtc cagctcgtcc tgcctcttga taatagcttt 2060641 ccatatcttt cgggatttgt gcatgcagaa caaatctgat atttgattta tcaataccca 2060701 ttccaaaagc agaggttgcc accatcactt gaagctcatc attaagaaat ctttcctgct 2060761 gctcttttct cacatcatca gccaaacctc catgataccg gcctgccctg acctgatttc 2060821 gtttcaatct ctcatatatc cgatcagctt cttttctggt cgctgtatag acaattcctg 2060881 cttcatgcct gttgttttgc acatattcgt ctataaaccg atctttattt tctcctttta 2060941 ctactttaaa ggttaaattc tctcgggaaa atccggtata taccgtgttt tctttttgaa 2061001 tatgcagctg tttgcaaata tcatcatgaa cctcgggtgt ggctgttgct gttaacgcca 2061061 tgatgacagg cttgtcgtgt aattcacgga acaagatttc aatattcctg tagcttggcc 2061121 tgaaatcatg gccccattga gaaatacaat gcgcctcgtc tattgcgacc aaaggaacat 2061181 ctatgccctg caaaatccgg ataaactcta tggacgttag tcgctctggt gtaatgtaaa 2061241 aaagcttata agccccttct ttgagtccgt tcagcctctc atatatttcc tgattggatt 2061301 gtgtgctgtt aatgtaggcg gcgttaatcc ccgcttcttc taacgcatca acttgatcct 2061361 tcatcaagga aatcaacggt gaaatgacga tcgtcgtccc ttcaaacatt aatgccggaa 2061421 tctgatagca aatcgatttg ccgcctcccg tcggcataat gcaggccgta ttttgcctcg 2061481 cttccgtcac caagcggatc gcttcatctt ggccgctccg aaacttctca taaccaaaat 2061541 aatgagccag aagggattgg gctctatgta acataacgtg taaacctcgc ttttccttga 2061601 atttctccca tcatatcata aaaaagcggc cttcatttct ttcacacaaa aatggaatat 2061661 tcactatacc aaaccttttt agataaaata aaaagccatt tccgaaaagg aaatggcttt 2061721 cgctacgtct tgccgtatgc aagtaagaaa gttttaaacc accactcctc aaagtgggtg 2061781 tttgcagaaa cgttcctgtc gtcctctgca atggaggcat gacattccgg cttcgatata 2061841 aaactcccta ttacagctta aaggttaaaa cttaattaac aatacgcaca aagtagcttc 2061901 tttaatatag tacaccatca ggcgctttta atcaagaggt cagaacaatt gtttagaaaa 2061961 actttttcca gtgaataaaa ctgttttttc tccaaaatac ctgacaattc gacaaacaaa 2062021 aaatatatta caataaaaaa aatagccttt attgctaaaa gcgaatgatt attttcttct 2062081 atattaatgt gtatatacaa aaagactcct atttgtaacg ataggagtct tggctttatt 2062141 agaattttgc agcaagatct tttgcttctt gtaaaccttt ttcaacgatt tcttgcgctt 2062201 gatcaggtgc tgcgttatgt ccttcgatga caactgtgtg caagtcttga acaccccaga 2062261 aaccaagaac tgttttcatg aagtttaatg acatttcaag tgcagccatt ggtccttctg 2062321 agtagacacc gccgcgagcg ttaagaagcg caactttttt gccgcccatt aaaccgactg 2062381 gtccttcttg tgtgtatttg aatgtaacgc ctgcgcgaga cagataatca acataagtat 2062441 gaagcactgc tggcactgtg aagttccaaa gcgggaatgc gaaaacaact ttgtcagctt 2062501 ttacaaactg gttcagatat ttgtcagcaa ttgctgcttg ttttttctca tcttctgtca 2062561 tttccattcc ttgacctgct ttaaatgttc cgttaatcat atctctgcca aggtaaggaa 2062621 ggttttcctt atgaagatct aattcaacca cttcatcatt agggttgttt tctttataag 2062681 cagctaagaa agcttcgtaa agtttagttg aaacgccttc ttcagctgta cggtcgcttg 2062741 attttacaaa taaaactgta gacatttgta ttcctcccgg taaacttttt atatttactt 2062801 acaaatagta tgttactttc ttttttacgt aaagtcaatc actttatttt gaatatgaga 2062861 ttttttttca aaaaaagcaa gtacatctaa tatcggtgta cttgcttggc atttttactt 2062921 cgaatcttgt tcacgatcca agatttcata cgtctgcgag cttttttgat caattgtttc 2062981 tttgttggat aagtctttta cctgttcatg aaactctctt tcataagaag gagcatctgt 2063041 ctccagatca tcctccacat cagcttgggc ctcaactgtc attcttgcat aaggaacagc 2063101 ttcaagtctt tcgtaaggaa tctcttggcc ggttttttca cacacgccat aagttccgtc 2063161 tttcatcttt tgtaatgcac ggttgacctc ctctaacagc tcccggtcaa tctctttcac 2063221 tgtttggtct gtcatccggt ctgtgacgag cgtcccgtgg tctgccatat ggttgtcaac 2063281 cccattggaa agctccccca cttcttccgt cattgattct gtttcctttt tctcgccaga 2063341 caattctttt tgcatatcga gcaatttatg atagagatgc tgtgtttgtt cttttgtcag 2063401 tgccatgtat atcctctcct ttctatcctg tttcccgttt tgccttctgt caaacatgga 2063461 aacatcgatg gaaagatgag ctactgcctt tttgaacgga tcgtgaccgc tggcgtcgat 2063521 ggtgcttcgg gttttcgttg gcactttttg tccttctctt ctggcggtat ataataggtt 2063581 gcgcctatat ttaatctgcc gctcagttca tcaatggtca gctcgccgaa ttcaagatga 2063641 tagtcaactt tttcgacatt cagcgtttca atatgtatat aggtttcttc agactcttgt 2063701 ttgctgcttt gtttttgttt ctcaatcact gagagtcttt cttcacattc acgcagtttg 2063761 tcaagttctg gtttcaagca atgcctgatc agcgaccgga acattttttt catgacatca 2063821 cgaccctttg catactcctc tttcgtctac atatataatg aggtatatcc catagaaagg 2063881 agaggttttc atgcttccga ctaacatcaa tatttctcat ctcaagacta actcgatagg 2063941 caccggctca tcccttacct ttggttctgc ggagttaagg aacaggtgct ctgctatcaa 2064001 aagaaataac ggttttgggg aacaaaatgc agatggtatt gttatggtca ttccgattga 2064061 atcaattgat gaccgtgatg tgtcagatgc actcagtatg aaaatcaatc atcaataaca 2064121 atggttttcg cttgaccttc gtctttttga atagtgatgt ataggattcc gtctttaaaa 2064181 atggcattca tctttccatg aagatgatcg gaaagcggaa ttttcttttc aaaacttccg 2064241 tatttccctt ctttttggcg aaagtcctgt tcattaaaat aggaaaagcg ctgccccttc 2064301 accactaaat aatctccgta cgataatatg tgaacgtctt gtttacggta gcctggaaga 2064361 taaattaaaa actgcacttc cgcaacggta tctacaatat ccatgctcgg aaatgaagca 2064421 tctcctttcc ctcgctgatc ttgctgcgca aacggaaacg gagattggcc atttgtcata 2064481 aaaggggttt tttggtcttc atcaaatacc tgtttccaaa agtcaccgcc gtacatctgc 2064541 tgtgcgaatt ccatccactg cttcatcttt tcgaaatcca tttgaagccc cctgtcttaa 2064601 catactttat aaccgccagc atacaactat agaaaggagg tttgcctgtg gttcaaccaa 2064661 ctccgtatat caatattaat attttcatgc tgaaaattaa ttcctttgaa aatgcttcag 2064721 cggttaacgt aggacaaaat ttattggcag aatggcaaaa ttcagataaa aaaaatcaag 2064781 gctacggaca gaattttgga gatgcgagcg gatttatggg cacgagaagc catgtggatg 2064841 acagagacca aattgattct ccggcctctt ttgaaagtga agcggttaac tcctcaatca 2064901 aaaggaagtg atgagatgtt cttttcaccc tccgtcgtaa atgtcggcgg atttaaaatc 2064961 aatacgatgg atcgaggttc ctctttaaca ctcggtccgt atcagcaggt cgattacttt 2065021 ttatcagcta aaataaatca agggtttgga gaagaaaatg gcgactttac tcctcttgtc 2065081 gtgccgattt caaatgtatt agatgcagat cttgttgatt cgaactcagc gaaaaacagt 2065141 gtggtgtaat aagaacaggg cgcacatgcc ctgttcttgt ttttatatat aaaaaaagcc 2065201 taaccatttt ttgaacggct ggctcatcaa atattcagct gcacaaatgc tttgtcagca 2065261 ccgcctgaac ctcgcttaaa tcggtgtctt tcgcaaattc taattcgaaa gttttgcttc 2065321 ttgtcatcaa taaaagccca gtgtccggat caaacattcc cgcttcttgg atggcaaagc 2065381 tttcaattgt tttatatgga agaaatacac gaaccttctt tttagaaaac attttattgt 2065441 caaagaaaat gatccgctta tttgtaaagc aaatttggtc cactcggagc ttataaatcg 2065501 attcaattct ttccccttca acgagcaaag cctcaagctt ctttgcgtcc gttgatctgc 2065561 taacagaaaa aatacccaat gaagaacccc tctttctgca tttatctatt tgttttatca 2065621 ttcactacat aaaaataagt cctttatccc tatataagaa tacgacatag aagacattta 2065681 aaccattacg aacagattac atttttcaaa tttttgattt gttttttggc ttttaagctg 2065741 ttgtcatcaa gtaatacgca catatagaga aaaaagtttc aatattcagc aatgttttta 2065801 taaaaaagtg gtttttaatg atttttttaa ttttgtttta tatttcctgt tttaaccaca 2065861 aaaaaaccgc agctgagctg cggttttatg tatcgactgc ttttaacaaa atctgtttga 2065921 tgcttcaagg aagcattaca tctcttcgaa gtattcttta taatagccgc cgactttatt 2065981 cgtattgtcg accacaaaga gaaactcctc tgtttcattt tttacttcat attcttttcc 2066041 cggcgttaaa acgcggttta cgatatattt ttttgcgttt gtctgcacac actttacttt 2066101 tttaatggtt tctttttcaa gccaattttt atgaatcatg atgaaatctc cttttcttat 2066161 ctataagctt attgtagctt ttttcttttg taaattgcaa tatcggttat tcattgattt 2066221 tgccttgatt tctattatag aatgtttgta tacgcttacg tttgaagcaa ctatcacagc 2066281 ttatttctgc tattcaatcc aggaatcaat gtgctatcac caagaatctc agaacagacc 2066341 ataaaaaatg actggaggtt tgttacggat gagttcttta acgatgcaag tgacgaaaag 2066401 gctggagaca tttttacagg gaacaaagaa gctttatatt gacggaaagt ttgttccgag 2066461 tgcctcaggg gcaacctttg acactccaaa cccggcgacc ggcgaaacct tgatgacgct 2066521 gtatgaagcc caggctgcgg atgtggacaa agctgttaaa gctgcccgga aagcctttga 2066581 ccaaggtgaa tggagaacaa tgtctccagc ttcgagaagc agactgatgt ataagctggc 2066641 agacttaatg gaagagcata aaactgagct tgctcagctt gaaacacttg ataatgggaa 2066701 accgatcaat gaaacgacta atggagatat tccgctggct attgagcata tgcgctatta 2066761 cgccggctgg tgtacaaaaa taacaggaca gacgattccg gtttccggcg cttattttaa 2066821 ttatacgcgt catgagcctg tcggtgtcgt cggccagatc attccatgga atttcccgct 2066881 cctgatggcg atgtggaaaa tgggcgcggc acttgcaaca ggctgtacaa tcgtcctcaa 2066941 accggctgaa caaacaccgc tttcagctct ttatttggca gaattaattg accaagccgg 2067001 tttccctgcc ggtgtaatca acatcatccc aggattcggt gaagatgcgg gagaagcgct 2067061 gacgaaccac gaagcggttg ataaaattgc ctttaccggt tccactgaaa tcggaaagaa 2067121 aatcatgtcc accgcagcga aaagcattaa gcgtgtgaca ttggagctgg gcggaaaatc 2067181 gcctaatatt cttctgccgg atgcgaattt aaaaaaagcc atcccgggcg ctttaaacgg 2067241 tgtgatgttt aaccagggcc aagtctgctg tgcgggctca cgtgtcttca ttcataaaga 2067301 ccaatatgat gaagttgttg atgaaatggc atcctatgct gagtcactcc gccaaggagc 2067361 gggacttcat aaagatactc aaatcgggcc tctcgtaagc aaggaacagc atgagcgcgt 2067421 tctttcctat attcaaaaag gaaaagatga aggagcaaaa gcagtgaccg gcggaagctg 2067481 tccttttgaa gcaggatatt ttgtcgcacc gactgtgttt gcgaatgttg aagacgaaat 2067541 gaccatcgca aaagaagaaa ttttcggacc cgtgctgact gcaattccgt acgaaacagt 2067601 cgatgaagtt attgaacggg caaaccattc agaatatggg cttgcagccg gactatggac 2067661 agagaacgtc aagcaggctc actatatcgc ggaccgactt caagccggaa ccgtttgggt 2067721 caactgctat aatgtgtttg acgcggcgtc tccatttggc ggttataaac agtcaggact 2067781 cggacgagaa atgggatcat atgccttgga taattacaca gaagtcaaaa gtgtatgggt 2067841 aaaccttgaa gactaacatg tatgtttaaa aaactgctgc ctgccagcag tttttttctt 2067901 tctgtaatgg cagtaaaaga cgctgaatat atatgcttct gaaggagttg agcgtgatgg 2067961 gcacacttca ggagaaagtg aggcgttttc aaaagaaaac cattaccgag ttaagagaca 2068021 ggcaaaatgc tgatggttca tggacatttt gctttgaagg accaatcatg acaaattcct 2068081 tttttatttt gctccttacc tcactagatg aaggcgaaaa tgaaaaagaa ctgatatcat 2068141 cccttgcagc cggcattcat gcaaaacagc agccagacgg cacatttatc aactatcccg 2068201 atgaaacgcg cggaaatcta acggctaccg tccaaggata tgtcgggatg ctggcttcag 2068261 gatgttttca cagaactgag ccgcacatga agaaagctga acaatttatc atctcacatg 2068321 gcggtttgag acatgttcat tttatgacaa aatggatgct tgccgcgaac gggctttatc 2068381 cttggcctgc tttgtattta ccattatcac tcatggcgct ccccccaaca ttgccgattc 2068441 atttctatca gttcagctca tatgcccgta ttcattttgc tcctatggct gtaacactca 2068501 atcagcgatt tgtccttatt aaccgcaata tttcatctct tcaccatctc gatccgcaca 2068561 tgacaaaaaa tcctttcact tggcttcggt ctgatgcttt cgaagaaaga gatctcacgt 2068621 ctattttgtt acattggaaa cgcgtttttc atgcaccatt tgcttttcag cagctgggcc 2068681 tacagacagc taaaacgtat atgctggacc ggattgaaaa agatggaaca ttatacagct 2068741 atgcgagcgc aaccatatat atggtttaca gccttctgtc acttggtgtg tcacgctatt 2068801 ctcctattat caggagggcg attaccggca ttaaatcact ggtgactaaa tgcaacggga 2068861 ttccttatct ggaaaactct acttcaactg tttgggatac agctttaata agctatgccc 2068921 ttcaaaaaaa tggtgtgacc gaaacggatg gctctgttac aaaagcagcc gactttttgc 2068981 tagaacgcca gcataccaaa atagcagatt ggtctgtcaa aaatccaaat tcagttcctg 2069041 gcggctgggg gttttcaaac attaatacaa ataaccctga ctgtgacgac actacagccg 2069101 ttttaaaggc gattccccgc aatcattctc ctgcagcatg ggagcggggg gtatcttggc 2069161 ttttatcgat gcaaaacaat gacggcggat tttctgcttt cgaaaaaaat gtgaaccatc 2069221 cactgatccg ccttctgccg cttgaatccg ccgaggacgc tgcagttgac ccttcaaccg 2069281 ccgacctcac cggacgtgta ctgcactttt taggcgagaa agttggcttc acagaaaaac 2069341 atcaacatat tcaacgcgca gtgaagtggc ttttcgaaca tcaggaacaa aatgggtctt 2069401 ggtacggcag atggggtgtt tgctacattt acggcacttg ggctgctctt actggtatgc 2069461 atgcatgcgg ggttgaccga aagcatcccg gtatacaaaa ggctctgcgt tggctcaaat 2069521 ccatacaaaa tgatgacgga agctggggag aatcctgcaa aagcgccgaa atcaaaacat 2069581 atgtaccgct tcatagagga accattgtac aaacggcctg ggctttagac gctttgctca 2069641 catatgaaaa ttccgaacat ccgtctgttg tgaaaggcat gcaatacctt accgacagca 2069701 gttcgcatag cgccgatagc ctcgcgtatc cagcagggat cggattgccg aagcaatttt 2069761 atattcgcta tcacagttat ccatatgtat tctctttgct ggctgtcggg aagtatttag 2069821 attctattga aaaggagaca gcaaatgaaa cgtgaatctt atcaagcgga gatgttcaat 2069881 tggtgtgaag ccctgaaaga tcagattcaa aagcgaggtc agcttgacca gtttgaagat 2069941 caaatcgaca agatgattga ggctctggaa gatgaccaaa caacagaaga agattggtat 2070001 aaacaggccg ctgcccttta tcgggatatt acagaatcag atgatacaag tgaaagacgc 2070061 gcttatgtcc ctatagggaa acacgtgctg ccaaagcttc cttacaaata ctccgcctta 2070121 gaaccttata tatcacgcga tattatgatc cttcatcata caaaacatca tcaaagctat 2070181 gtcgatggcc tgaacaaagc agaatcagag cttaaaaaag cgagagcgac aaagaattat 2070241 gacttaatca ctcattggga aagagagctt gcgttccatg gagcaggcca ttatttgcat 2070301 agtatttttt ggttttctat gcatccaaac ggaaaacggc gtcctacagg ggcattgttc 2070361 caaatgatag acctttcatt tggaagctat tccgctttta aagaacattt tacccaggcc 2070421 tctaaaaaag tggaaggcgt cggctgggcc attctggtct gggcacctcg atcaggacgg 2070481 ctggagattt taacggcaga aaaacaccag ctctttagcc aatgggatgt gatccccctt 2070541 ttaccgcttg acgtatggga gcatgcctac tatttgcaat acaaaaatga ccgggccagc 2070601 tatgtcgatc actggtggaa tgtcgtggat tggcgcgagg ctgaaaaacg ttttgagcag 2070661 gcaaaagaag tcgtttggaa gctctattaa aaaaagcccc ctttcctcgg gggcttcgtg 2070721 tgttaaaaaa tacctatcac atgcaaaaac acgatgatga tggcaacagg agatagatat 2070781 cgaatgagca gcagccaaac cgcaaaccac tttcgtttga gattggaacc gcttttcagc 2070841 tcgtcaaaca aatcctgttt cggtattttt agcggaacaa aaatcgaaat cagtaacgca 2070901 cctaacggca ttaaaatatt gctcacaaga tagtcagccg catcaaaaat agacagatga 2070961 aatatagtga cgtcacttaa gacaccgtat gataatgcag acggcacacc gacaataaaa 2071021 atagcaatac cgcctaacca agcgaatcgt tttctcttat tgatatcgcc tttcgacagt 2071081 actgcgacca aaatttccag cattgaaaaa gcagatgtca atgcagcaaa taaaaataga 2071141 agtaaaaatg ctaataaaaa gataattccg aacggcattt gattaaacac agtcggcaga 2071201 acgttaaata acagaaccgg gccttggtct ggcttgaggc cgaatgaaaa tacagctgga 2071261 aaaatcgcaa ttccggccat tacagcaaca agcatgttca taacagttac agatacagcg 2071321 gactgtacca gattttcctg tttctctaaa taagcgctat acgttaccat gacagataca 2071381 ccgacactta ataagaaaaa ggattgtccc attgcatata aaatggtatt ggcatcaatt 2071441 gcagttaaat caggcatgag gaaaaatttg attccttcca tcgcgccatc aagtgtaacc 2071501 gaacgcacca ttaaaatgat gaataataga aaaagcgccg gcattaatac ttggcttgct 2071561 ttttcaattc cgctgcttac cccttttgca acaactaaaa ttgttaccac cataaagagc 2071621 agctggcctc ctacagccaa ataaggattt gaaatggtac ttgcaaatat cgtatcaaaa 2071681 ccagatgttt gcgataaacc gccagtgaag ccttttataa tataaattaa aatccatccg 2071741 cctacgacac tgtagaaaga tagaagaata aagcacgtca ccatgcctaa ataaccgatc 2071801 caatgccact tcgttcctgg agcaagtgtt ttataggact gaacggcatc tttctgtgtt 2071861 cttctgccta tgatgaattc acctaacaat aaaggcagtc cgattaaaac cgtaaataaa 2071921 ataaaaataa gtaaaaatgc gcctcctccg ctggttccgg caacatatgg gaatttccat 2071981 atcgcaccaa gcccgatagc tgatcctgcc gcggctaaaa taaagccgag cttcgaagac 2072041 cattgatttg cttccttcac cgtatcactc ctatttgatc taaccattat aaaggttcat 2072101 tgtaagaata tcttcctata tagtcaagaa cattttaatt agtttacatc atatatctat 2072161 agacatctgc caaaaactaa tattgaatta ttcagaaaat tatttataat aagagaatgt 2072221 tatgaaattt gtaagaattt ctgctgaagt tcttgataag tgtgttagga gtgtttttat 2072281 ggacatcatt agaaaaataa gccattttgc aggacaaacc tttggcatat gggtcattgt 2072341 ttttgcagtg ctgggatttt ctttcccatc tttatttacg tggatcagtt cttatattac 2072401 gatttttctc ggcattatca tgtttgggat gggccttaca ctgcaagccg atgatttcaa 2072461 agagctggtc agaaagcctt ggcaagttat tattggagta atagctcagt atacgatcat 2072521 gccgctcgtt gctttcggcc tcgcatttgg gcttcatctt ccagctgaaa tcgcagttgg 2072581 tgttattctt gtcggctgct gtcccggggg aactgcatct aatgttatga cattcttagc 2072641 aaaaggaaat actgcccttt ctgttgcggt tacgacaatt tctaccttat tggcacctgt 2072701 tgtaacaccg ttgttgatta tgctgtttgc caaagaatgg cttcctgtct cgccggggtc 2072761 tttgtttatc tcaatcttac aggcggtttt atttccgatc attgcaggtc tgattgtcaa 2072821 aatgtttttc agaaaacaag tggcaaaagc cgtacatgcc cttccgcttg tttctgtcat 2072881 tggcatcgtt gcgattgtct cagctgtcgt cagcggcaat cgggaaaatc tgcttcaatc 2072941 ggggttgctc attttttcag ttgttatcct gcataacggt atcggttatt tactggggtt 2073001 tctttgtgca aagcttttaa aaatggatta cccgtctcaa aaagcgattg caatcgaagt 2073061 cggcatgcaa aactccgggc ttggggctgc acttgccacg gctcatttct caccgctatc 2073121 tgccgtacca agcgcaatat tcagtgtgtg gcataacctt tcaggttcta tgcttgcaac 2073181 atattggtca aaaaaagtga aaaagaagca agctggatcc aaaagcagca atctatcact 2073241 ttaaatatgc atcaaaaagg gtacatcact ttatcgtgat gtaccctttt ttattatcct 2073301 tctaataaaa gctgttcagg atcttccagt aaatttttga ttgtcacgag gaaaccaacc 2073361 gcttctttac cgtctacaat tcggtgatca taagataaag cgatatacat catcggacgg 2073421 ttttcgaaac gctcttcatc aatggctaca gggcgcagct gaatcttatg catgcccagt 2073481 ataccgactt gcgggctgtt taaaattgga gttgacatca atgaaccgaa agtccctccg 2073541 tttgtaatcg tgaaggagcc tccctgaagc tcgctaaggg ttaatttatt gtttcttgct 2073601 tttttcgcaa gctcgccgat ctctttttcg attcctgcaa atgtcaggcg atccgcatcc 2073661 cgtacaaccg gaacgacaag accttcatca gcagcaacag cgattccgat atcgtagaat 2073721 tttttaacga tcaactcatc gccttgaatt tctgcattca acagcggata ttttttcaat 2073781 gcagccacga ccgctttcgt gaagaaagac ataaagccga gcttcacttc attttgctca 2073841 aaaaattgat ctttgcggcg ttttctgaga ttcatgacag ccgtcatgtc cacttcatta 2073901 aatgtagtca gcatcgctga tgtttgctgt acctctacaa ggcgttttgc aatcgtttgt 2073961 ctgcggcgtg acattttttg cacttcaaca ggtttgtcaa agctttgctg tgctttttga 2074021 gcctgaggct gctgcttttg ctgaggagcc ggttttgatg ccggtttttc gtacgcttcg 2074081 acatcctgct tgcgcactct tccaagcgga tctccagttg gaacttgaga caggtcaatt 2074141 cctttttctc tcgcaagctt acgggccgac ggagaagcga tcgttcttga ttttgcttca 2074201 gattgtgctt cctcgctcac ctcttgtgca gctggttcag cctgtttctc ttcttttacg 2074261 ctttccttgc tttctgtttt ctctgtagga gcaggggcag aactttcacc cgcgccttct 2074321 gaaatcgtac cgataatttc tccgacctgg acggtatcac ccgaatcttt caatacctct 2074381 tgaagtacac ccgattcttc tgctgtcaat tcaacattca ctttatccgt ttctagttca 2074441 agcagatatt caccctgttc tacatagtca ccaggctgct ttaaccattg ggctattgtt 2074501 ccttctgaga ttgattctgc taattcaggt accttaattt ccgccatttt ttcatttccc 2074561 ccttagtttt tgcgagtcaa gctatcagat acaatacgtt cctgttcttt tttatgaact 2074621 gtcggatctc cctctgcagg gctggatcgt cttcttcgtc caatatattg aacgcttact 2074681 ccctctggtg caatctctgt caaatacggg ctgatataac cccaagcccc catgttctgc 2074741 ggctcttcct gcacccaaac gatttctttc aggttcggaa gttttgcaaa taattctttg 2074801 actccttttg ccgggaatgg atacagctgt tcgattctcg caatgtgaag ccactcttta 2074861 ccgtcttcta acttattaaa atgatcgcta atgtctatag acactttacc gctggataat 2074921 acaagtctgg ttactttttc atagtcatga gaaagtcccg actgttcata aacaggctgg 2074981 aagcggcttt cgctgagctc ctgcacttcc gacaccgtat ttgggttgcg aagaaggctc 2075041 ttcggcgtca taatgacgag cggtctgatt tcttcacgaa gcagcatttt agcctgtctt 2075101 cttaaaatat ggaaatactg tgccgcgctt gtcaggttgg caaccgtcca gttgttttcc 2075161 gctgcaagct gcaggaatcg ctcaattctt ccgcttgagt gctcaggccc ctgtccctcg 2075221 taaccgtgcg ggagcagcat gactaatccg gatttttggc cccatttcgc gcgtccggca 2075281 gaaataaatt ggtcaaaata cacttgagca gcgttggcaa aatctccgta ctgtgcttcc 2075341 cacaaaacaa gcgtttccgg tgaatgcacg ttatagccgt attcaaaacc gagaaccgat 2075401 ccttcagaca gcgggctgtt atgaacagca aatgatgtgc tgcagtcaga taagtgatga 2075461 agcggcacaa attctttgcc cgtctcactg tcatgaagca caaggtttct ttgggcgaac 2075521 gttccgcgct cggaatcctg tcctgttaaa cgaatcggtg ttccgtcttt caaaattgaa 2075581 gcaaacgcga gtgattctgc caaagaccat tccacttttc tgtcatcatc gaacgccttg 2075641 gcgcgtcttt ctaaaatgcg ctttagcttg ccgaaaacat taaatgactc cggccagttg 2075701 atcaattcgc cattcagctt gcggagcaca tcaaaatcaa tcgaagtgtc cacatctggg 2075761 aaaccgtttg atacaggctc tggaagttca atttcacaag cagtgtgttc ctttttagac 2075821 ggaactttct gatatgcatc ctcaatgcgc ttcgttaccg atttttcgat gttttgaacg 2075881 acttcctcgg taaccacgcc ttcttttacc agcttttcag cgaaaatttg tttgacggtc 2075941 ggatgctttc tgacagcatc atacagcatt ggctgagtgg ttgacggttc atccatttcg 2076001 ttgtgtccat agcgtctgta cccgatcaaa tcaatcagaa aatccttgtt gaatgttttt 2076061 cggtattcga ccgcaaactt aacagctgaa agacaagctt caggatcgtc cgcattcacg 2076121 tgaacaatcg gaatttcata acccttggcc aggtcgctgg catattttgt cgatctggat 2076181 tcagcgcttt ctgttgtgaa tccgatcatg ttattggcga taatatgaat cgcaccgcct 2076241 acttgatacc cttttaaaga gcttaaattc aatgtttcag ctacaattcc ttccccaggg 2076301 aatgcagcgt ctccatggat taaaatggcc agcgattttg tttcatcttg taccgggtat 2076361 ccgctttgtg ttcgcgtttc ctgtgccgct cttgtgctgc cttcaacaat cggattgata 2076421 aattccaagt ggctcgggtt gttcgctaac gtaatgcgcg ctgattttgt ttcagcgtct 2076481 tgaagctccc gattcgcccc caaatggtat ttgacatccc ccgtccatcc gtagctgatt 2076541 ccaatggatc cctcagacgg tacaagatct ttgttcggcg catgctggaa ttcagagaag 2076601 atgatttcat acggtttgcc gagcacatgt gccaagacat tcaggcgtcc cctgtgcgcc 2076661 atcccgatgt tgacacttgt cgtgcctgat ttgacagatt gtgcaataat gtcatcaagc 2076721 actggaacaa gagcgtccag accctcaatg gaaaagcgct tctgcccgac gaatgtgcgg 2076781 tgcaaaaact gctcaaagcc ctctacttct gtcaatcttt ccagcacagc tgacagcttt 2076841 tcagctgagt tcttctggaa cagctcgcca gattcaatct ttcttgtcag ccactcgcgc 2076901 tctttgaagt catgcacatg gtcaaattca aaagagatgg ttcttttata cgtatttcgt 2076961 aaatactgaa tggcttctaa accgttcgaa atgtttttag gagcgtcttt gcagatgaca 2077021 gacgcaggta ttgcttttat ttcctcttct gttagcccgt aatcggataa tggaaaaagt 2077081 tcgctctttt tctcatcctt tctgagcgga ttgacggaag cgttcaaatg gccataggtt 2077141 cggatatctt ctgcaagtct gactgcggat gcgatctttt gaatcagatc ggctgtaaca 2077201 cgtccctttt cttttgttcc cgaggcctct tttatatcgc ttggcggagc accgagctcg 2077261 tcgaacattt ccttcaaatc cgggtcaatg ctgttcggat cctgggtata ctgatcgtaa 2077321 agctccagcg catagccgag gttcggaccg taaaaatctt cccaattcat tcgttgtttc 2077381 atactatttt gaaacatttg aatattaccc ccaacttaaa taatcaagtg attgattcac 2077441 tatcttgaaa taactttcga acgctgtgtc caaaattatg taataaaaac gcttccaacg 2077501 atattttacc actgtttgca atttgattct accttgattg ttcacaaaat agtaaaaaac 2077561 ctttataaaa aacaaaaaat ttaatcattc gaaaaaacaa acgccaaaaa gcataggatt 2077621 aagggctatc ctatgctttt atgaagcagt tttttcagca gcggatacaa aacatccggt 2077681 agctgatcaa catccgggac aaatatactg aattttccgt acatatcctg gatcgtcttc 2077741 atttgcgatt cttctatttc tgagttggag agaaaaacat ttatcacttc tattcctctt 2077801 tttcgggctt cgataaccgc ctcacttgta tcaacgatcc cattttgttc gtagccaaat 2077861 gcggccggct ctccatctga gaaaacaatt aagaactttt gcgcctcgct gcgatgcagc 2077921 atttttttcg tcatctgcct aattgcgtac ccgtcacggt tatcttcttc tggctcaagc 2077981 tgcataatgg ccggtccaga atcttgtctt aatgatgatt ggaagggaat aaccgtattg 2078041 aaatagtttg gctggctttt ttcggttgca tcatttgtgt cctcccaaaa accgacaatc 2078101 tgatgcggaa ccgctaccga tttcaacgct tcgtgaaaca gcacgattcc tcgttttgtt 2078161 tcgtccattt tgtcgaacat gctggcggaa caatcgacca gcaatgtaaa aactgcgtcg 2078221 atttctgaag atggttcttg ctttttgtag aacaggcgcg gatttcgctc agtgaagtaa 2078281 cgaagaagct tattgttcag tctcccggca tgaaggtctg ttctcggcaa tgttttttta 2078341 tgctccagcg ttttttgaat catttgtttc aaacgctttt gatacgattc aatcgttttt 2078401 gcctgctgtt tataagaaag ctcttcttca ctggttgccg gctgcggttc tttataaatt 2078461 ggaaatgcat atttattttc tttgccgtca gccatacccg ctccgttcgg ctggtctttt 2078521 tgggactcca gcgcttccag cttggaatag tctttccgtt tcgtttgtct ggctgatcct 2078581 tgaacagagc caagggcctg atctccatcg tcgccttccc ttgaagcatc ttttcctaaa 2078641 tctgattttg cgccgtgttc aatatcaaat tgaaggaagc ttttagacgg tgcttctgtt 2078701 tcccggtgcc atgtcggcat ttcttcttca tggatatcct catcaccgtc tgattgtttt 2078761 ggaagcgtga tgtcatcact cagcttcggc gcttttttct cttcttcaaa taacggctgt 2078821 tctgcagctt ttgcgtaatc aagctcaggc aaaaagaagt aggtgttcaa catgtcttta 2078881 tcgagtacct cttcaagtcc gtccatgagg tcctcaacaa ttttcagaac ctgccgtgtc 2078941 gaatctgctt catacacacg caagagctgc tgctcaataa acgggcgcat cagatcgata 2079001 tcttcacgca tggatggaag ggtctcgagc ggcgattccg ctgtgagctt gaaatagatc 2079061 gcgcaaaaga gcgcatcggt aaaaatgctt cgttccaaat ttaaggtcag ctgggttgag 2079121 aaatgttttc tgtacatgtc ttttcgcttc gcaaatacat gtttcgtacc cgggcgctca 2079181 cgtttgatgc attcttcgat cctaatgtct tcaagcagca taaagagctg cttggcaaaa 2079241 cttttaaacg taagatggcg atggatatca ttcaaaaagt tcgcaaactc atgcagcgag 2079301 ctatatcttg ttccgactga acgcaggtag acgtcgcttt tcagacccgc ttccatgtcc 2079361 tcagctgccc tgtctttcca aaagtggctc atatagattt tcttttcaaa tggattgtaa 2079421 taggactgaa cgccatactc cacttctacc gcttcactct tggtgagtgt tttggccaaa 2079481 tcagtcagca tcataaataa aaatgaatca atcgtgctgt cgttaaattt gataaatttc 2079541 atcgcagccc cctcattcaa acagagtttc tgcaatattt cggacagccg ctttttcccg 2079601 atcatcatca agcttttcta caattccccg ctcaatggca cgacgcggcg gaatataagc 2079661 agctaaatca catgtatcga ttaaagctct gatggatgcc gcttcttcag acacctgtcc 2079721 gttattggcc tgaacgatca agtcagagga aagcgtgata aatctgtcaa tcaatttctc 2079781 gtctttcaag gctgactgag acatgagcac ttgtttcagc agctcgcctt taatataagg 2079841 cacatcaatg atgacaaaac ggtttttcaa cgcttcattc agaggaacag ttccgacata 2079901 gccttcattg atggctgcaa tgactccgaa accgctttta gcccgtatga cctcgcctgt 2079961 aaacggattt gtcatcattt ttctgtaatc taatacaccg tttagaatag gcagtgtttc 2080021 cggcttcgcc atattgattt catctatata aagaaaatgg ccttccttca ttgcctttgt 2080081 aacaggtcct gaaacaaact cgattgttgc ctggccagat tgattttcaa tcgttttata 2080141 accgaccaat gcctcagcgt ccaagtcgac tgaacagttg acgctgtgca tcggtttatg 2080201 aaaatagctg gacaatgttt ctgccagctt tgtttttcct gaacctgtag gccctttcag 2080261 caggacattt ttccccatgg ctaatgcaat aatggcgtca aataaaatgg cttcatcctc 2080321 cgcctcatag cctgatgttc ctataagcga ttgaaactct ggggaaatag gctgctcttt 2080381 atatgataaa agcttttgtt gtatatcttc cggcaatgtt aagtgctgta gttgagttgt 2080441 catagacaga ttccctttcc tattcatatt ccattaacga gtatactaaa aaagcccctg 2080501 tatgctcaat acaaaagggc ctggatgata ttactgcttc tcgttatttc ccaaaagggc 2080561 tccgcagaca atacgcgcac cggaattgcc gcttgggttt gtcagataat cgtccgcttg 2080621 ttcatgaata ataaatgcac ttccgtcctc gtcgagaata tttagtttac ttcctttttt 2080681 cagtgaagtg tcaggcgcat tcattatgac atctaccttt ccatcagcac cgacttcaag 2080741 gttcggcaga tctccggcat gatgccccat cggattatta aagccgtgtt ctttgttcag 2080801 tggattaaag ggaccgcccg ctgattcaaa atccggcctg acacaagaac ctttctcata 2080861 aatatgaaaa ccgagagaag cacctggacg caggctgttt gcggaaatat gaatatcgag 2080921 gccttcatca tctgattctt tgatctctat aaaaccgact gctttccctt cacgattgac 2080981 cagctggaca tgatgaccaa acgctgacgt ttcaaccact tttttttccg gcacccggtt 2081041 aggagggtct ggaggttttt tttgtccgca tccggcaact cccagtgccg tcagcatcat 2081101 caacagcaag agacggtgca tactgtctcc cccttgtttt ttctaacagt gtggtcaatc 2081161 attgtctggt ataaacaaaa aagcctataa aaggcttttt gtcatactca tttttaaaaa 2081221 taacttcttg cgcccaagta ccgctgtttc caatacgaat tgctgagatt ggaaatgtcg 2081281 acgcccgatg agcttgcatg aataaaatca ccgccgccta gataaatccc catgtgagac 2081341 gggccggatt tatatgtggt aaagaagaca aagtctccta ctgacggctg gctgactttc 2081401 tgcatgacat tccaataccc tgccgtactc aatcttgata tagatgatac attattaatg 2081461 aggtaataaa tgaagccgct gcaatcaaaa ccggcaggcg tgtttccgcc ccatcggtaa 2081521 ggcactccga catatttttt cgcttccgtt atcattctgt caatcttcga acctatttga 2081581 atgtttgacc ctgagttatc ttttggcttt gttggctttg tcggatttga aggattagat 2081641 tttgatgctc ccgaaatagt cagaacctgc ccgatttgca acacatccga tgataaattg 2081701 tttttatcac ggatgctttg gacagtgact ccgagccgat ttgcaatttt ccacagcgaa 2081761 tcgcctgctt ttaccttgta cgtcgttgtt tttgagggat tggagtttga cggctttttg 2081821 gaaccgctgt ttccgttctt aggtgaactg cttcctttta ttttgagcac ctgtttagga 2081881 taaagtgtat ctgatgttaa gccatttaag gtttttaatt cggctacagt catatttaag 2081941 ctgtttgcga ttttccacag tgagtcacca agcttgaccg tatatgtact ttttgaagaa 2082001 cctgaagaat tggaaccgct gtttttcttt gatccatttg atccgcttga actgcttgtc 2082061 cctttgatct taagcttttg ccccggacga atcaggtcac tgctcaggct gtttaagctt 2082121 ttaagctcag aaacactcat tttatgattt ttagcaatca tccataggga atcaccatat 2082181 gcaactgtgt atgttgatgt tttgcttgaa ttagatgggg atgtcgtgct ttttttgctg 2082241 ctttcaggaa ccttaagact ttgtccgaca taaagcaccg ttgatttcaa tttgttttcg 2082301 gatttcagag ctgatattgt cgtatcatac tggcgggaaa gtttccaaag agagtcaccg 2082361 ctttttactt ttatcgtttt tgcttccgcg ggtgctgcgg ccatcgacga cccaacaact 2082421 gcagaaacag ccaagccggc tacaatcttc tttttcattc attcaacctc ctaaactgtt 2082481 tttttgcaaa aacagctagt attttgtttc caaaaatggc acacaactgt tttatcgtca 2082541 atttttcagc aagttaaacc cttttcaaac atttggcgca gcattttcag catcgttcga 2082601 cctttaaacc ttcaaataaa catctaacat tttacataag cacgatatgt ttttcgaaag 2082661 tctaaggaac tatttaagcg agggtaaaaa tgatggtttt ctattgatga acgaagcagt 2082721 ttctcctcct ttcttgtcta tttttctaat caattctcta tcggcgtgtc aaatcccttc 2082781 ctctgcattc ttatgaaatg gcaaaaagcc tgttctttcg ataagaacag gcttttacac 2082841 tatgcatttg ctgattgagt tttttgtttt acagcttcaa gaatgctgtc ggctgctttt 2082901 ttagagccgc ctgccgcttt cagtgattgt ccaatttctt ttgccttttc agcatacgaa 2082961 cgattattca ttacttcttg tatcgtctct ttcagtaggc tttcagacaa ttcttccttt 2083021 ttaattactt ttcctgcgcc gactttttct acctgatctg cgacaacaaa ttggtcgcct 2083081 cccatcggaa tgacaacgag cggggtttca aaatacaaac cttcacttgt gctgttcatt 2083141 ccgccgtggg tcacaaataa gctggctctt ttcaagatct caagctgagg gacatacggg 2083201 cgtacaatga aattctccgg aatgtcgttt aactcacttg ttttaatatg cttgccgatg 2083261 gaaagcacaa ctttaccgtc aaagtcctta cacacttcaa ggcattgatt aaaaaactgc 2083321 ttttgattat taaaaatggt tcccattgaa ataaacagca cgttttcatt gtcaatctga 2083381 tcaaatggga aatcattgtt tccggctctt tctgtaatgg aaggaccgac aaatacatat 2083441 cgctcgccaa attgctcagc cagtggctga aatccccttg atgtaaagac gattgtcaag 2083501 tcaccatcag ctaaaaaaac atcaaatggc ttcttgatct ctgcttgaaa atcagcattt 2083561 aacgtttctg caagctgctg gtatgattca taatgaggcg aatcttcaag tgatcctttc 2083621 atgtacgctc ccatcatttc cttcgcaaat tcctcattca tcgcaaaggt tgtacacaat 2083681 gaaaatcttg gcagcttcag catgttggca atgactttac ccgcgagaag atggtgatca 2083741 tatatgacat aatcatacga ttcatgtttg acttcctcat aaatatgagt cgcgatatcc 2083801 ttacaggctt tcaaaaaagc gcagagcatt tctgtgaaat ctctttcttc atcgccggtt 2083861 gcgtttttcc cgaagtaatc tcctctgaaa tcatgatact cacgaaactc tatatcaaga 2083921 gctgtgattt tttctttata ttccttcact gcgtagtacg taatgttttc tccccgggat 2083981 ttcagctcct tcatcacacc gatagaggga ttaatatgcc cttcaccggg gaaaccgatc 2084041 attaatacat tagccatgcg gcagcaccct tcctttgaga atttatgtaa tattttatac 2084101 ggtactataa atgcataaac aggtaaagta tttcacttaa ttaatattca tcatatataa 2084161 cttttctacc agtttatatt ccctgtcttc aagacaaaaa gcattcagct tgaagcgaat 2084221 gctttaataa agatgcgaat tcagtcattt tgtctcatga taggattctt aatcaggccc 2084281 tttttattat ttttacgttc ttggtgaaat taacggatat aatacaccgt ctttggcaaa 2084341 cgacatcttc cctgtttcct ctgaaaccac gagcaccagt gcatccgtat agcccgacat 2084401 accaagagcc gcccggtgcc gggttcccaa atggatatcc acttccttcg tcgtcagcgg 2084461 gagcacattg gctgctgaca cgagtttgtt ttccctcact aataaagcgc cgtcatgaag 2084521 agggtttccg ggaaaaaaga tgctttcaat taatgaagag ctgatctcgg cgtgtaggga 2084581 ggtgcctttt tgaataaaac gttcaaccgg gtctgctctt tcaatcacaa ttaaagctcc 2084641 atgcttatgt tccgataagg ctttaatcgc cttggccagc tcaataaatg ccggcgtaaa 2084701 ttcctcaatg tatgattgca aataaaagga ggatgcaatc ccctgcatgt cctgaaaaac 2084761 gtgccccaaa tcatctaatt cacaaaggag acactggtct ttttcgtgaa gcgttttcaa 2084821 gattagagat gcatcaccta atatttgctc taagtacacc tgtattttcc ccttgaacgc 2084881 attttctgat atctgctcat agcgcatagc cttcatctcc tgtttaaatt tccaactttt 2084941 cacgaatgct tatcttattg atgcacattc tattggtaaa ggagggatgt aaagaatgga 2085001 aatcgaaaga atcattcagt atatttgcac ctttttaggc gtgatttcgc tttcttttat 2085061 ttatgcccaa atgtttagaa aaacgaaacc gacaaaaaaa gaataggccc ggcgttcatt 2085121 gctttttata cataaaatgt tataatttct ctcgttatga aaaagaaacg gagatcaatg 2085181 tatgaaagaa actcaaaacg cccgggaaaa aatcaaacag ctcttgcaca ttttaatacc 2085241 gatattcatt acccaagcgg ggctttctct gatcactttt ctagatactg tgatgtcagg 2085301 gaaagtcagc cccgctgatt tagctggtgt cgccattggc tcaagccttt ggacccctgt 2085361 ttacacagga cttgcaggta tattaatggc ggtcaccccg attgtcgctc agttattagg 2085421 tgcagagaaa aaacagaaga ttccctttac tgttttacaa gctgtatacg tggccgcgct 2085481 tcttagcatc gccgttttag tgattggata tgctgcagtt gaccttattc ttggccgatt 2085541 gaaccttgat attcacgtgc atcagattgc taaacacttt ttaggctttt tatcactggg 2085601 aattttccct ttatttgttt acaccgtgtt gagatcattc atcgactcat taggaaaaac 2085661 gagagtcacc atgatgatta cactcagttc tcttccaatc aattttgtat tgaattatgt 2085721 atttatcttc gggaagttcg gaatgccggc acttggaggt gtaggcgcgg gactggcatc 2085781 cgcgttaact tactggtgta tatgcatcat cagttttttc attattcata aaaacgcacc 2085841 gttttctgaa tacgggattt ttcttaccat gtataagttc tcttggaaag catgcaaaaa 2085901 tttgctcaaa atcgggctgc ctattgggtt cgccgtgttt tttgaaacga gcattttcgc 2085961 agctgtcacg cttctcatga gccattttca tacagtgacc atcgcgtccc accaggcagc 2086021 catgaatttt gcgtctcttt tatatatgct gccgcttagc gtgtccatgg ctctaacaat 2086081 tgttgtcgga tttgaagcgg gtgcagcccg ttttaaggat gcacgctcat atagcttaat 2086141 cggcatcatg atggcgatcg gcttttcttt gttcactgcc gcctgtatcc ttttattcag 2086201 agagcaaatt gcgggcatgt acacttctga ccccgatgtg ctccggctga cacagcactt 2086261 tttaatttat gcgctatttt ttcagctttc cgatgctgtt gccgcaccga tccagggagc 2086321 actcagaggg tacaaagatg tgaactatac gcttgcggcc gcttttgtct cttactgggt 2086381 cattggcctt ccggtcggtt atatggtcgg tacgtttaca agcctcggtg cattcggcta 2086441 ttggattgga ttaatagcgg gactcgccgc cggagcagtt gggctgtttt tcaggctggc 2086501 aaaactgcaa aaacgttatt cgcaaaaaca acacatttaa aagaggtgat caatcatggc 2086561 aaaaaacaaa aaattattcg agtatctttc ccagcatgcg gaaaccatca gttcaacatg 2086621 gtatgaaaca atcgaggaga ctgatcccaa ttccatttat gcctcaacag accctgttgt 2086681 cattcacaat ttaaagagcc agaatcttgc ctttaactat aaaataaacc gtatttttat 2086741 agatgatgag gacgtatact tgcctatact gaaagaatgg gcctttgaag tcacacagga 2086801 tcaagagcat ttaaaaactc ctatccacta tattattcgg gagtttgtca gagtgagaga 2086861 tttatatgtt tcttatgtga aagaatttgt ccatctcaat cagaatactg tgaaaagcga 2086921 agaagccgaa gacctgtatc acgcccttat aaaagcgttt gatcttgtga ttcatatttt 2086981 tatagaagaa atgtacaaaa acacaagcct tcagcttcag gcccaaaaag atatgattac 2087041 tgaattgagc gctccggtca tcgtgctgtt tcacagcgtc ggactgctgc ctttaatcgg 2087101 agatattgat acagtccgcg ccaagctgat tatggaaaac acactgcatc aatgtgcgaa 2087161 aaaaaaggtg acacaactgt atattgattt gtcaggagta gctgtgattg atacgatggt 2087221 tgcccatcag ctgttcagtc tgattgaggc gcttcgttta atcggtgttt cttcaacttt 2087281 gtctggaatc cgtccggaaa tcgcgcaaac agcggttcag ctaggtttgt ctttcgaagg 2087341 tatttccttg agatccactc tcgcttcagc tattgcatcg gacttaaaat taaaaaaggt 2087401 ataaggctta aggccttata cctttttgat taatcattcc attgatacgt ccaatatatt 2087461 tcttcttcaa accatgttgc cataacaggt tcattatttt tcaatttctc ttcaagctct 2087521 ctgagcatgc cttctgtttg tgtgcggtga gctcttaacg cattcatttt aatatcagct 2087581 acttctttga tatcaagtac gacatcagct tcgccgagaa cctcttctct gttgcgggta 2087641 atggccatgc agattgtacg cggacggtct tctttctttt tgcggtataa tgcacggata 2087701 accgcttccc cgcatgcatc atggtcaggg tgcacaccgt gtccgggata aaatgtgaca 2087761 attaaacttg gttttacatc atctatgatc tcttccatga tatcagctaa atactcatcg 2087821 tcttcaaatt cgagcgtttt gtcacggagt ccaagcatcc gaaggtcatt gatatccatt 2087881 tctttgcaag cgttgatgag ctcttgtttt cttagcagcg gcaacgtttc ccgattcgcg 2087941 aaaaatggat cgcccatatt tctgcccatt tcacctaaag tggcgcaggc atacgtaacg 2088001 ggaatgtctt tttttctgtt taaggcaatg aggcctgcca ctccatatga ttcatcatca 2088061 gggtgaggca ggattactag tacatgttct ttcattatta ttcacccttt tctttaaact 2088121 gtgaacggtt tttcgctgat ttgcagagaa atagccagtt taccgcccgg caggtgtccc 2088181 gccattaata aacggttttc ttcatctacc gtgtattcag tcaagccttc agcataaatc 2088241 cagccttctt ctgttttcaa gccaacgcgg taaggcccgt tgcctttgat ttttgcctga 2088301 tgataagtga cttttgcatt gcgaatatac gcaacaaccg tcatgttctt ttcatttaag 2088361 tgcgctgaat aagaacctgt ggtggtttct aaatggatat atacagggcg gtccgcatat 2088421 cgttctaaag atgcttgcac atcttctttt atgatcgctt tcatgattgc tcccctcttt 2088481 cttcttttaa atactctgca cgttctgtat gtaatttgac cagctgatat ttcacagccg 2088541 gttcgagctg tgaattcaca atgcgctgaa tcgcggcaaa atatttttcc agcatcggtt 2088601 ttcggagtct tggatgtgtt cgtttatcca agagctcaag atcaatcgcc tctgctaccg 2088661 cttctgcgtc atcatgtgcg agagatcggt tattccaaag tgaagcatag gctttcacta 2088721 tctctttatc attgtccatc gtcttgctcc tttatgtctt acatacatga aatgattata 2088781 cataatatat gcatcagctg aaaagccaaa ggcctcaatg gctttttgac gcccgtttcc 2088841 acttcacttg tgaaaacgta aacaagagca gcgcagccca tatacagctg aatgtaaaag 2088901 ccttcgagct tgaaaatggc tcatggtaaa caaacagccc gatcagcagg gtaatggtcg 2088961 gcgcaatata ttgtaagata ccgacttgat acagtggcag ccgtttcgct ccttccgcaa 2089021 acaataagag cggcaaagcc gtaaacacac cggccaaaaa gagaagcagc cacgtccctc 2089081 cgctttctgc acccgctggc tgaacatgtc cgctgaacag caaatacccc aatgcaatgg 2089141 gcataatcat gaatgtttcc agcgttaaac cgatggcgct cggcaggctt gttctttttt 2089201 tgcttaaccc gtacagccca aagctgaatg cgagcagaag cgcaacataa ggaatggagc 2089261 cgtattggaa cgccgagatg atgacaccgg ctgccgcaat cgaaacggcc actaattgca 2089321 ggcgattcag tttttccttt aaaaataaaa tcccaaggag cactgataca agcggattaa 2089381 tgtaatagcc aagactagcc tcaagcaaaa agccatggtt gacagcccat atgtatacaa 2089441 accagttgat cgaaatcagg atagaagcaa gaaataaaga gaggatccct ccgttctttt 2089501 tcagagagcg caactcctgc catcctattt tccattgccg caagaaaaaa agtacgatac 2089561 acataaaaac aaaagaccat ataatacgat gagccaaaat atcaagagcc ggcagctgtt 2089621 cgagaagctt ccaatagagc ggaaacaggc cccacatgat aaatgaaacg gctgtgtaaa 2089681 taacgccttt ttttgtttct gcatgttgca ttgatatccc tgcctttctt tagagcatct 2089741 tatattatat cacgtgaaag atctggtggg catatactat tttgtccgtg aagaaaggat 2089801 gtgaagacaa tgtttgagtg gaacaagtac tttcctttcc acaatcaatt ttctaaagaa 2089861 gcattaaaaa aagctgatcc gaaagaagtt gaaacgtatg tcaatcgtgt gatggaaagt 2089921 gtgttcggca gtgattatgc ggctcaattt cctttccgcg atcctctccc ccaaaaagaa 2089981 catcccgcca aacctgatgc aaaacctgat gtcaaacctg atattgatat attcgaaaca 2090041 gcagaccatg tgtttgtaaa ggtgccaatc agcgaagaat ggctggaaca agtgagaatc 2090101 aaacacacat ctcacgaatt atggttggaa aacctcccaa gagcagatca tccgaaaaaa 2090161 gtaaaccttc cttgtttagt caaacgcaaa ggaacaaaag ccgtctataa ggatggcctt 2090221 ctggaagtca tgtttcaaaa gcagcaagac tacaatatgt ccgaggtaga aatcatccga 2090281 taaaaaacgg cctgcaatcg atgcaggccg ttttttatta atagaagccg ggatatcccc 2090341 cgtatggcac gccggcacca aaaccgtacg gtccgcctcc atatccataa gggccaggag 2090401 gataggcata gggacgagaa tagttaaaca gcgcactccc gagaaaaccg cctaataaac 2090461 cgccgactag aggagcgcca aacaaaaaag gactacgcgc cggatatccg gctggacctg 2090521 ggattccgcg taaatacgaa tgatgagggt acatgatttt ttcctccttt atgtctgcct 2090581 atacgtaaag tattcagcaa ggaagaaaaa cgattgggct acggactgtc tatgattgtt 2090641 acatcacaag ccctgccaat aacacacagc cgagccctgt aaccgaaaga actgttgtaa 2090701 gcagcgtcca ggtttgaaat gtttctttca tgctcaagcc gaaaaattcc tttaccatcc 2090761 aaaatcctgc atcatttaca tgacacgcaa tgacactgcc ggctcctgtt gcaagcacca 2090821 ttaacgcagg gtttacactg ccagcctcca taagcggagc tgccattccc gctgtggtaa 2090881 gcgcagccac ggtagcagag cctagacaca gacgcagaac cgcggcgatg gtccatgcaa 2090941 cgaatagcgg cgacatgttt gtttgacgga aaaaatcagc gacataatcg ccgactccgc 2091001 cgtcaatcag cacctgttta aacgctcctc cccctcctat gatgagcagc atcatcgcaa 2091061 tttgcgaaat tgattctgaa atagatctgc cgatttcctg catagatatt ttacgggcat 2091121 atcccatcgt atagagtgca agcaacagcg aaatgagcat tgccgttccc ggagtgccga 2091181 taaattctat aatgtctttt ccttttgaat gttcactcaa taataaagaa aaaattgttg 2091241 ccattgccat aaagataacc gggaataaag acgtgacagc actgatcgca aagcccggtg 2091301 tttcatccag ctgaaattct ttccttggtc ctaaccccga taggtttcca tgcttttgat 2091361 acgcaccagg aaaccgtttc atcgcaaatt tattaaataa aggcccggca atcacagttg 2091421 tcggaacagc gatgatgatt ccaaaaagca gcacctggcc aatatgggca ccatatgcaa 2091481 ctgagatagc agttggagca ggatgcgggg gcaaaaatcc gtgagtaaca tttaaggcgg 2091541 cggccatcgg gattcccaga tacagaaaag gcatttttaa ttctttagca atcgcgtaaa 2091601 caatcggtat caacagaaca agaccgactt caaaaaatag ggcaatcccg atgataaaag 2091661 aggcaaccac aaccgccgcc tgtattcgtt tcctcccgaa tttgtcaatc agcgtaatgg 2091721 cgatccggta gccgccccca gcatctgaga caagcctccc aagcatcgcg ccaagtccaa 2091781 acactaaagc taaatgcccc agctgcccgc caattccagt ctcaattgaa agaacaattt 2091841 tattgatatc cattccaagt ccgatggcta ctaaaaatga aacgacaatc agtgagacaa 2091901 aggtatttaa ttttacttta ataatgagaa ataacagaat cagcactccg acagctacaa 2091961 ttaaaatcgg catggtaccc ctccaaaagt gttttatatg attctcgcga caatgttttg 2092021 gcgcttttca tgcctagatg aacagaaagc gctttcatta ataactaaaa acgtcttggt 2092081 tatatgattg ttatcttttg atcaactaat atgttcatac taatctccta atcaatgact 2092141 gtcaatcgtt tttatgagct tgtctcgatt acctaccgcc taacccaatg atttattagt 2092201 tatatgttga ttaacttttg gttatatgtt atgtttttta aagttgactg ccaatcatta 2092261 tatctctcca ttgtctggaa gcaaatgaga caatatgaga acagacggat aacaacttca 2092321 taagaggagg agtacacatg ccattattgc gttttgatgt aattgagggc cgtgatgaaa 2092381 aatcgctgca attgttatta gatactgctc accaagcgat ggttgaagca tttggtgttc 2092441 cggaaagaga ccgttatcaa attgtccatc agcatcccgc aaacgagctt ataatccagg 2092501 atgcgggatt agggtttcag agaaccaagg atatggtcat cattagcatg acaagcaaag 2092561 caagaaccga aagccaaaag gaaaaattgt atgctctgct tgctgaaagg ctagaaaaaa 2092621 aatgcgaaat ttcccctgac gacctcatgg tatctattac tgagaatggt gacgcagact 2092681 ggagtttcgg tctcggtgag gcgcaatttt tgaatggaaa actataagat ttcgtctccc 2092741 cacaaaaaaa agaagagaga gctccaaaga agctctctct tttttcataa atgcggaagt 2092801 catcagtata gaagcatcca gcaatacgaa aaacctggat ctccttttat atccggttta 2092861 aatgccaatt ggaagctgac tgggttttgg ctgaaaatat aaaattttgc tgatttgcat 2092921 aataagatac atcataatcc ccatttacaa taggttggat gttatagctt attgatcatt 2092981 tcctatttta tatatcccct tcatatgcac atgacatttt tgccaatccg gaaatatcag 2093041 tctgacaaat ataaaaagtc atgtaaacgg gtgtgaaccg tacttacatg actcaccatg 2093101 gaaacaaagg ctctttttca ggtgccgctt tccttatttc tcttcttcac acactgtgtc 2093161 accaggctcg caaaattgat cggcccatgc ctgcatttct tgaaatacag cttgaagcgc 2093221 tgttcctttt tcagtcagcg tgtagatgac tttgaccggc gtttcaggga gaacctgccg 2093281 ttcgacaatc tcgttttgtt caagctcctt caagcgctct gccaacattt tttggctgat 2093341 catcggtatt gtttccgtta tctctttaaa ccgtttcggc ccatccatta gcacatggat 2093401 gatcagaccg ttccatcgtt ttcccagcaa tgagaatgcg gattccattt tagggcacat 2093461 cgtatttccc ataagtcttc atcccttcat ctattgattg acatgtattc aatgatccat 2093521 tacaataatc tttcaagtta catttagtaa gcttctaact tttctattat cataccacgt 2093581 ttatccgaag gaggaaacac tatgacgaat actctggatg ttttaaaagc acgtgcatct 2093641 gtaaaggaat atgatacaaa tgccccgatc tctaaggagg agctgactga gctattagac 2093701 cttgccacta aagcgccttc tgcttggaac cttcagcatt ggcattttac agtattccac 2093761 agcgatgaat caaaagcgga gcttcttcct gtagcgtata atcaaaaaca aatcgttgag 2093821 tcttctgctg ttgttgccat tttaggcgat ttaaaggcaa atgaaaacgg tgaagaagtt 2093881 tatgctgaat tagcaagcca aggctatatt acggatgaaa tcaaacaaac attgctcggc 2093941 caaatcaacg gtgcttacca aagcgagcaa ttcgcacgtg attccgcttt cttaaatgct 2094001 tctttagctg ctatgcagct tatgattgcc gcaaaagcaa aaggttatga cacttgcgca 2094061 atcggcggat ttaacaaaga gcagttccaa aagcaatttg atatcagtga gcgctatgtt 2094121 ccggttatgc ttatttcaat cggcaaagca gtgaagcctg cgcatcaaag caaccgtctg 2094181 ccgctttcaa aagtatcaac ttggctgtaa ggatatgaaa aaccttagtc cgaaatccgg 2094241 actaaggttt ttttatacaa tcgcctcttt gtaccattca cgagcctgtt cagcttcatg 2094301 ctgagtcagc tgatggcccc cgtcctgcca gtaaacggag gctgatgccc cgctgtcacg 2094361 caaatagcgg taaagctctt ctgattcttc cttcgtgcaa agaggatcgt atttcccggc 2094421 accgataaaa acagggagcc ccgccatatc aggcagctcg ataccccgaa tcggaaccat 2094481 tggatgatgc agaatagccc cttttaacac atctttataa tgaaaaagca ggcttgccgc 2094541 aatgtttgcg ccgtttgaat aaccgactgc aatcactcgg ccgcgattaa actgatgcgt 2094601 ttctgcagcc tcgtcgataa aatctttcaa ttctcttgtc cgcaccacaa gatccttttc 2094661 atcaaaaact ccttcactca gacgtttgaa aaatcgcggc attccatttt caagcaccga 2094721 tcctctgaca ccaagcaaat gggcatcagg gtctataaac cgccccaatg aaagcagatc 2094781 gtgttcatta ccacccgtgc catgcaacag caaaagtacg ttgtcagatg ttcctttctc 2094841 ataaatatgc ttcattataa attccccctt ttaaagttca ggtaaaatgt ctgtaatttg 2094901 ttgtctatgt ttctccagcc attcaggcag ttttaaggaa gtccctagct cagcaaacgt 2094961 ttcatctgtc ataaagcccg gttcatctgt ggcaatttca aataagatac cgcctttctc 2095021 cctaaaataa actgatgtaa agtattccct gtcgagaatt tctgacgaag gcagatggtt 2095081 ttcagcaata atcggcagcc atttcgcctg ttcctttttc ttagtccgaa acgctacatg 2095141 gtgtaccgta ccatatcctc cgactcctct tttttcagga tgtaaatgga catcaatgac 2095201 accgccgacc gccgctgaag atgccagtct gacaatctgg tcttcttcgg ccactttggt 2095261 gtatccaaag ctttccgtta acaattgtat ggtcgcctgc gggtcgtagg aatatagcag 2095321 cacacctttc attcccgtaa ttgcttcatt tgttgtgatc ccgtcaggcg tccactcgct 2095381 tttgccgctt ttcgcatcct ccatgatcgc cagcggaagg tcttctgtat catcaaaaat 2095441 aagacctttt tcaccaaaca acgttttttc ctctaggctc agcccgcttt tctcaagacg 2095501 ttccttccaa aaagacaggg agcctgaggg aactgaaaag tacacccggc ccgcttggcc 2095561 ttttcctacc gttccctgtc cgcttccttg gaacggaaaa aaggtcatta ttgtaccggg 2095621 atctccgttt tgattcccaa agtaaaaatg atacgttccg ggatcatcaa agtttactgt 2095681 ttttttaacg agcctgagcc caagcacttc tgtataaaat cgcaagtttt cttgcggatc 2095741 tctggcgaat gctgtgacat ggtgcaatcc ttctgttttc attttctcac tcctatttat 2095801 ctcgatttca agatatttat tattttaaac ctttattgaa aaggatgcaa accatgtgtt 2095861 ttgattaaat aattgaaaaa atcatttttt tctaataatt atcttgtgat cttttcttac 2095921 aactgctatt atagtgagca ttatcatgtt tcaggaggaa agtaaatggt taaaaaagca 2095981 cttattgtta ttctcattct tttgccattc gttcagctcg cgcttttgcc gcttgtgaat 2096041 cgaatagaac cgattatgtt cggcctgccg tttttccact tttggctgct gctgtggatt 2096101 attgttacgc cgttatgctc gtttggcatt tatcagatgc aaaaaaaaga tggaggactt 2096161 gaataatgca agggaatctg actgcacttc tcattactgc tattattgtt ttaaccgttg 2096221 tctgtatcgg ctttctcgcc ggaagagaca aatcctcacg tacttctgtg gaagaatggt 2096281 ctgtcggcgg cagacgcttc ggcggtcttc tcgtctggtt tttagtaggc gctgaccttt 2096341 atacggccta tactttctta gggttgacca gtactgcttt tacaggcgga agtgttgcat 2096401 ttttcgccat tccttattct gtgttggcct actttatcgc ctacttcttc ttgccaaaac 2096461 tttggaaagt tgcgaaaatt cataaattaa caacactcgc ggattatgcc cgggaacgtt 2096521 ttaacagtaa gcttttggca agcctcgttg ccatcgttgg ggtactcatg cttattccgt 2096581 acatatgcct tcagctgagc ggcattcaag acacgcttca ggttgccggc actggctata 2096641 ttaacgtaaa attcgttgtg atcatttcat ttattcttgt tgctctttac acattcttca 2096701 gcgggattaa agggcccaca tatacagcca tcattaagga cattttagta tgggtcatta 2096761 tgctgtttat ggtggtgtcc ctccctctca ttcattttaa cggctggacg ccaatgattg 2096821 acacgttagt gaaggaagcg ccgcaaatgc tgacgatacc gtcagaaggg ccaaaaggca 2096881 ttccttggtt tatcacagca tctattgttt ccgctctggc actttttatg tgggcacatg 2096941 ccgctacagg tgttttcacg gcgaaaagcg ctgatgcagt aagaaaaaac agcatgtttt 2097001 tgccgcttta taatatcgtg ttaattttgg ttatttttct tggctttatc gcctttcttg 2097061 ttctgccgga agatacaaat ccaaggctgg cgctgctgca tttgattcaa acatcttacg 2097121 gcggcgtggc acaaggcttt gcatatgcca ctatcgctct tgcttcatta ataccttgtt 2097181 ccattatggc aatcggcgca tcgaatttat tcgccaacaa cctataccgg gatttgattc 2097241 atccgaatgt gtcgcaaagc aagctgactc ttgtcacacg ttcaatggtg tttgttgtca 2097301 tcggtcttgc gctgctgttt ggaatgctgt tcccgactgc cttagtgaca cttcagctat 2097361 taggtgtatc cggtatggtg caaatcttcc ctgcgattgc tgtcagcctg ttctggaaaa 2097421 accaaacgaa agaagcaacg gttatcggat tattagccgg cctagcggta acgtttattg 2097481 tgtatatcac tcaatccgca catggcattt atgaaggatt ctggggattg gccgccaaca 2097541 tgatcgctgt ggtcatcctg aatccgctgt tcgttaaaaa cgcgggatcc aatcctgtca 2097601 ttgaaggttt atttggcaaa aaacaagacg ctaatccaaa tcaaaagggc gcataaaaaa 2097661 accatacgcg gcagccgcgt atggtttttt ttacatttct tttttcagtg tttcaattgc 2097721 cttttccatt tgcgtatcat tatcagacag cttcttttga agttctatca ttaatttcgt 2097781 tgttgtatcg ccagtcagta tgcctgtttc attcagcttc tcttttttct ggaactgttt 2097841 gacgacagat acaaaatcct ggtcatacat actgttaacc tttaccttgt aaccaagtgc 2097901 tttgagcatt ttctgagcca ctttgacgtt tgtgcctgta tcacctgatt tgtacgtttt 2097961 atctgcgtcc aaatacggca gcttcgcgta atcaggcagc tctgctttca cttgaggctt 2098021 gatgcctttt ttgtgaatcc attcgccatc agcagtcagc catttggcaa ctgtcagttt 2098081 gacggtagag ccatcatcat attcttttgc cgtttgtact gtacctttgc cgaatgtcgt 2098141 ctcgccgatt aacggtacgt ttgacgattc atgaagggca gcggccataa tttcggctgc 2098201 gcttgctgta ccgtcattta ctaaaacgac ggtcggcttg gtcactttcc gttctttttc 2098261 ggccttcatg acttcttttg aaccgttttt gtattcaacc tgcatgatgt ttttcccttt 2098321 atcaatgaac aggttgctca tcgtaatcgc ctgttccatt aagccgcccg ggttgcctct 2098381 caagtctaaa atatagcctt tggcgccttt tttctctaaa ctgtcaatcg catctgtcag 2098441 ctctttagct gttgtttcag agaaagaagt gatttgaatt tctccgatgt tgttgtcttt 2098501 catctctgaa tagacagtct ctacaggaat ggtatcgcgc ttaatggaaa gatcgatatt 2098561 ccccactccc gctctgttca gttcaagctt cacctttgtg ccctttttgc ctcggattaa 2098621 agcgacggct tcatttacat tcatgccttt tacgcttttt ccatttacct taatgatttg 2098681 gtccctcggt ttgataccgg ctttttcagc aggtgaacct ttaattgggg atacaataag 2098741 gatttctccg tctttctcct ctacttgggc tccgattcct tcaaaagatg ctgaaatcgt 2098801 ctcgtcgaat gatttcgctt gctcttgatc catatatgta gaatacggat catccagtga 2098861 ttgaatcatt cctttaattg ctccgtctac taatttgtca tcatctgttt tttggtaata 2098921 atcacttttg atttgctcat acgctttatt taatttgtcg aacttgctgt ctcctgtgct 2098981 tgctgatttt tggcccagga tactggaatt gcccgtaata aataaagtaa gcgccgaagc 2099041 gacaactgca gtgatcagca caataaaaaa cagttttaat tgccgtttca attaaacacc 2099101 acctttttct tcttacatta ttatcatgga cgaattctta ttcgtcaact cggagcagaa 2099161 atgaaagaga aacgcccttc ttttgctttt cataaaccta tgtctttata cgacatatga 2099221 taaggaaaaa ggaggattcg atattgagcc gatatttaga aatgctgtcc ttattcggtg 2099281 tcgcaggggc gcacccaggc gggctggctt tttcaaaagc ggtcttgcaa aaggctgcac 2099341 cctctccgga tcagccgatt cttgatgccg gatgcggaac agggcaaacg gcggcttatt 2099401 taggacattt gctgtatcct gtaacagtcg ttgataaaga tcctattatg cttgagaaag 2099461 cgaaaaaaag atttgcgaat gaagggcttg ccatccctgc atatcaggcg gagctggaac 2099521 atctcccgtt ttcttctgag tccttttcct gcgtcctgtc agaatcggtc ctcagttttt 2099581 cacgcctgac atcctctctt caagaaattt caagagtttt aaaacccagc gggatgctga 2099641 ttggtatcga agctgcttta aaaaaaccaa tgccccctgc agaaaagaag caaatgatgg 2099701 atttttacgg atttacttgc ttacatgaag aaagcgaatg gcataaactc ctaagatcct 2099761 atggctttca aaaaacagaa gcgatgtcac ttcttccgga agacatggaa tttgaaccaa 2099821 ccacagaaat ggatttatcg caaacgattg atcccatcta ttacgatacg cttcaaacac 2099881 attatcagct catgcagtta tatagtgagt acatgggtca ttgtattttt atcgcgtaca 2099941 agtaaaacgg cgtatcgccc cctgttttcg tccaaccttt ttttcctatc tatcatatgc 2100001 tgatagaaag tcaggatagg aggggaacaa tattggagag atattatcat ctttgcaaaa 2100061 accatcaagg taaagtcgtc agaattacag agagaggcgg gagagttcac gtcggcagaa 2100121 ttacccgtgt aacaagagac agagttttta tagctccggt cggcggaggg ccaagaggtt 2100181 tcggttacgg atattggggc ggttattggg gatatggagc ggcttacggg atttccctcg 2100241 gtttaattgc aggagtggct ctggctggtt tattcttctg gtaagcatag aacaaatgct 2100301 agattcacca gacacaatga agcccgctta tctagtgtaa gcgggctttt cattttaaat 2100361 tttcttcact ttttcaaagt actcttcaag cgttaaatca ttatcttgga tgacctttgc 2100421 ggcttttttg cctacatagc gcagatgcca tggctcatat tcatatttcg tgatatcttc 2100481 tttatttttc ggatagcgaa taataaagcc atatttataa gcattgtcct gcacccattt 2100541 cccgtctgcc gtgcttccga acgcttcatt tagctcaaag ccattgctcc ggctcgaaat 2100601 gtccatcgca aggcctgttt gatgctcgct ttcacccggg taagcgaccg cttcctttgc 2100661 cttcctttcc ccttttaggc ttacttcatt gtcaaaaatg actttctgtc tgtcatacga 2100721 acggtaccct gagacagctg ccagttcata gccttccttt ttggcagcat cgaacattgt 2100781 ttttaatgcg tcggccgctt cttttctgat gtaacgtttt tgaatctttt cttcaaaaga 2100841 aaactctaca tcaggtatga caagatcgct aggttcatag tttccgggca gtgcatattg 2100901 tttattgaca agcgcgagta tattttctgg attttgaatg gtttccagac catcgacttt 2100961 tttaatatca ttgaaatact ggctttccaa tgaaaactca ctgttttgag tgtttgattt 2101021 tttgctgtca gctgtttttt gttctgtttg ctttgtttct gctgtggttt tcgtatcctt 2101081 ttgagcatct ccgttcgaca tgctgcagcc ggctccgact attgccgtta cactcagagc 2101141 ggcagccagt gagaaccatt taccggactt tttcatatta cattaccttc cttttatcaa 2101201 tcgtttccgc atgcataaag aagaggctgc cggcacccag cacgcctctt gatatatttt 2101261 attgtgatac ggaatgtaaa gccacttcta tcatatcatg aaatgtcgtt tgacgctctt 2101321 ccgctgtcgt ttcttctcct gttaatacgt gatcactcac ggtgagaatt gacagggctt 2101381 ttcttccgtg cttcgctgct aatgtataca atgcagttgt ttccatttca acgccaagca 2101441 caccgtattt tgcaagtttt tcaatttgcg aatcgtcatt gtagaactgg tcagctgtaa 2101501 atacgcttcc tacagtcacc ggcacacctt tatcctttgc ggcatcatag gcatttttta 2101561 aaagctcgaa atctgcgcaa ggcgcaaaat caacgcttcc gaaagcaact ctgttcattt 2101621 gtgaatcagt tgaggaggtc atcgccaaaa tgacgtctcg cactttgaca tctttacgaa 2101681 tagcgccgca ggaaccgact cttattagat tttgcacatc gtagctttga attaattcat 2101741 tcacataaat tgaaatagac ggaactccca ttcccgtgcc ttgtactgag atttttttac 2101801 ctttatatgt acccgtaaat ccatacatgc ctctgacttc attgtagcat tctacatttt 2101861 caagatacgt ttctgcaata aattttgctc tgagaggatc tcccggcaaa agcacagtat 2101921 ccgcaatttg tcctttttca gcacctatat gtacactcat ctcatatcct cctgtaaatc 2101981 taaattatca tccagcccgt ccattttaca acgaatgtca tgatgaaaca aacttcagca 2102041 ttgattataa aggaatatat cgaaaaaaga aatgttcgag gatctgttag gcacttcctc 2102101 agaaaaacgg ataatcgggg tgttaatttg aaaacctaac cgcaggaagg aggggtggga 2102161 catgggtaaa aaacatcgta accggatcac cggccaaaaa aagaacaatc atatacctga 2102221 aaaagatatc attgcagctg aagaagcaca cgggaaagaa tattccgctg ccaaacgcaa 2102281 gccttaaaac tgcagaaaac tgcgggtttc cgcagttttc ttttcattat gtcgtttgta 2102341 caatcagacg attgattttc ctccagccgg cgggaagcag ttgataatat gttttccctt 2102401 ttctgccttc atcaatcagg atcacgtccc ctgtggccat gaatcttgca tcataatcac 2102461 tcggaacagt gtcgaataca ttaaacaaag agaatgctct tttcagcacg tcttgatgat 2102521 cgctcccgtt cagttcagtt cgatagacgg ctctgtagcc ctttttttcg ccaaaccggg 2102581 gtgtctgaaa tattgtcacg tcataggaac aagacttctt tttaaacacg gataacatca 2102641 tcaagatccc ctccctttta tttctttaac atattggcgt ttttgctgtg ttttcctctc 2102701 tctatttttg tcgaaaccgc ttaatctttt cgtcaaaacc ttttactagg aaaaacagaa 2102761 gcaagccgag gctaaagcct cctaacacgt ctgtcacaaa atgaaccccc agatacactc 2102821 tgcttatgcc gactaaaaca gcaattacac cggctatgat atataccatt tttttatgct 2102881 tagacaaaaa cgggagatgt ttcactaaaa agtaagcaat aacaggatag acacaagcag 2102941 cattcatgga atggccgctc ggaaaactga aggatgattc atgaaccagc ggtgcaaaat 2103001 caggcctcac tctttcgatc cattctttta agactttgtt taacagccga tctgtgccga 2103061 atactaagag catcaacagg ccgtcccatg tttttctgta gaaaaacatg cctgctccaa 2103121 tgatgacaat tagagggagc agaaaagaag aagcaccaag atgcgtgatc cccgtcatga 2103181 cttcattaag ccatggctga cggatcaaaa cagctgcctt gcttattgct tcatctgcag 2103241 attgaacagc atttgtatga atggccgcag ctagaattaa aaagaaaaga aacaaactaa 2103301 cgggcttgta caattttaac cacctcaatt ttcacagaag tcatagaaca tgaataataa 2103361 aaccggagct gaccgctccg gttttaagcc tcactcatct tcatccagct cttcatctat 2103421 catacatttt tctatcaaat aatcaaaggt aatatcagcg atttcaaaca gctcatcctc 2103481 actcggtatg tagccccgtc ttgcaagctc tctgtaaaaa aattcagcga tttcttccgt 2103541 atcaatcaca agatctattt ctttcatctc cgtaccgcct ccttttttat gttttatgaa 2103601 aaaacaggct gaattatacc cggtgttcta aacaattctt tcagtcatat attgaataaa 2103661 aaacgagcca tgggaggctg acgctatgat tgctaaaatg atggaagcac tggacggaga 2103721 aagatttgat atcataatgg aaaaaacgct caaaggaatg acgcgtgtga tgatttgggg 2103781 ctgtctgcca tattttttat atgtcttgat ccgtatgttc acaaattaac tgaaatgctc 2103841 ttttaaactt tccaaaacaa acatcatcat gtctttatat tcttcatcct gaaacatttc 2103901 gtacagaatt ttgtagtcat tataaatatc cagaagctca tcaacaattg acacagcaag 2103961 gatgtgaagg gtatcttgat cttcatcacc gccttcaaac tgaagaagag cagacgatgc 2104021 gatatcttcg ccgatctcat ggccagtttc tccgacataa tggacaaaca acagctgatg 2104081 cacaaactgg tccatttcat attttctaag caccagcgtg agatcctctt cctccgtttc 2104141 aagccactct ccatccttta aacgggtcag ctcataaatg atatcttccc agccatcttc 2104201 taaatatctc caaatttctg ttctatggcc gataatgcga aagagttctt ttccataatc 2104261 tttaacataa acaacgtccc caataaggaa ttcatactca atatcaagct tctccatgtc 2104321 gacaatgaca ccctcataat ctttataaag ctgaatagat gattcaaagt ataaaacttc 2104381 gttatgattg acttcataaa gatagtgttt atcaatttgg tgtacttttg tgatggtgcc 2104441 gactgttcca tacataatga cgactacgat atcccctact tggaatttcg gtttattttg 2104501 cttcatggtg tctccccctc gccgcaacat ttctcatacg ctatcgtatg ccgggtgaag 2104561 ccaattcgca tgggcatgaa aaccaaagga aatatccaat tatggtatgg gtatggacat 2104621 aaaaaaatcc gcagtgatct gcggatgaaa cagctattat ctgccgtgca cttcagactc 2104681 gtattgatcc caagcttcat caaacgtcgc catcgtgtga aggtaatcag cattcagctc 2104741 caaatatgaa ctgatttcat gataatcggt tgatgttttt ggaaagctgt gatcctcata 2104801 cgcctgattg gcaaattcac tgatgctgtc cttcggctta gggtgtctgt atttcaataa 2104861 atagtgataa aaggatttca tgggtttccc ctcctgatgt ctgtcttttg ttgttctatt 2104921 atacagttca agtgtaaaat tacaacaaaa gaatactgaa acatgactca ggagaagtca 2104981 aaatagttgc gtttcaaaat tctttctgtc tccatgagct gctgatatgt caggctttca 2105041 ggcagttttt ttgtttgaat taaaagcagc tgatcctcaa tctctttaac cgtgttttcc 2105101 tcttgatagg tcataccgca ggaagaacat accatggcag gggtgtctgt cagttctata 2105161 gccctcgttc catcagggag ctcccagtac accgtgttcc tgccgggcac cgcttcgagc 2105221 tcgccgcacc attcgcatgt tttcatgaag aatcccctcc gcattcagtc tctttctgtt 2105281 ttttctgctg cgccaaaaat ttcttttctt tgagctgatc tcttttctca cgccgatctt 2105341 ttaatgtttc atgctccgga tttgcgatgt atgcctctct ccttttgatt ctgtctacat 2105401 tttcaggtgt aaacgaaact tctttgtcag caaaaatggc actcagcccg atcggctcct 2105461 ttttgtcagc ggtttcaggg aaaacggact caaaataggc gtctgcctga ttggggatat 2105521 aattctctgg ttccggatat gacgtaatca caccttcaaa atttcttaag atcactttgt 2105581 caggactttg tgacaggaca tagtttggct gcagggcgat tttacctcct ccgcctggtg 2105641 cgtcaacgac aaaggtagga accgcatagc ctgaggtatg acctctcagc ccttcaatga 2105701 tctccaaacc tttggaaaca ggagctctga aatgccctat tccttctgac agatcacatt 2105761 ggtaaatata ataaggacgg actctgattt ttaccaagtc atgcatgagc tttttcataa 2105821 ttggaaccga atcattaata cctgctaata cgacagcctg atttccgacc ggcactcccg 2105881 cgttcaccag cttttcacat gcctcaacgg attcttctgt catttcgatg cttgtgttaa 2105941 aatgggtgtt cagccagacc ggatgatatt ttttcaatat ctcgcacaga tgatcggtaa 2106001 tgcgctgcgg aaagacgacg ggagctcttg ttccgattct gatgacttcc agatgcggaa 2106061 tgctgcgcag ctcttttaaa atatattcta aaatttggtc gttgatgagc agcccatcac 2106121 cgcctgaaat taaacaatcg cggatttcgg gtgtttcccg gatataagca attgcagcat 2106181 caagctgttt tttggggacg cccattccga tttgtccgga aaagcgcctt cttgtgcagt 2106241 agcggcagta catggaacat tgattcgtga caagaaacag cacacggtcg ggatagcggt 2106301 gtgtcagacc gggtaccggt gaatcttcat cctcatgaag cgggtcttcc agatcgtatt 2106361 ttgttttgtg catttcttca gaaagcggca cagactgcat gcgtaccggg catctcggat 2106421 tgtcggggtc cattaaagaa gcatagtaag gtgtaatatt taaggggatc gttttggtag 2106481 aaattctgac gccttcctct tcatcctcgg tcagattaat gactttcttt aaatcatcta 2106541 acgttcttac agtgtgtgtc agctgccaaa gccaatcgtt ccatttctct tccggaacgt 2106601 ccttccataa ctcgatctcc ttccaatgcc gtttcggttt ataccatttg tttttcaaac 2106661 gaactcctcc tcgcgcatat tttgacttac agttgcttgc accaaatatt catgttttca 2106721 aggccttcgg ctataaagca attattgatc agccttccgc catactgata acctgaatgg 2106781 tacaacacag cattcatccc aaaagacgaa gcacgggcga gagaaaacac atgaacgata 2106841 tcctctccag ccatttcttt ttctaacgcc tcgattaaaa agcttgttaa cgaatggccg 2106901 cgatattccg gcagcacagc gcaatcggtt atttctgcat gcccaagctc tggattgatt 2106961 tctgcgcttg ctgcgctgat caggcggtca tgatcaagca tgatataata caccgtattt 2107021 gcattcatcg tcttttcaat ataagcgggg tcaaataccg gggttgggta cgtgcggaat 2107081 acttttttat acagcatcga tagctggtac atgtcgtttg tttctgcttt tctcatcgta 2107141 aaaacgggtg tactgtcgtt gcgaagacgg ggcgctgtgc gatatatggc ttcgatgatc 2107201 tcctgttcct ctgtataaga atctgtttgt ctccggcttt ctgaaaggta acgtaccatg 2107261 acacaagccg aatggccgag ataatagccc tttagatagc cctccggcgc aaataattgt 2107321 ttggcaagga tcggctcatc atgctgcttc gcatagacaa tgattttttc tgcattctct 2107381 tcttttgccg ctgccacgat atccggcagg gccttctcaa tggctccgtc ataacgaacc 2107441 actctgattc gtttattaaa gccgtcatgg tccaaaactg ctgtgacacc gctactcttt 2107501 attgacttga gcatccgcat cctccccatc tgtatgaagg ccgcaccaat ccatgacaaa 2107561 aagtgcaata attttagcag attctatcat ggcttcaacc tcaatgtatt cattggcctg 2107621 atgagccgtt tttgtttccc ccggcccgaa aacgatcact ggtgtatctc ctgcatggta 2107681 caaaagccct ccatccgttc cccacgggga agcctcaata atcggctctg tctgtttcat 2107741 tttttgatag gctgattgca gcacagaaat taaagggtga tcatcaggta aatcattcgg 2107801 cagccattga gcgccaaacc attcgacttg tacgggatgg cgtttaaacc attcgtcatg 2107861 gtattctaaa tccttcagcc agttttccaa ttcaagtttt acagcttctg gtttctcatg 2107921 gggagcaatt ccgcatctcc cttctatgac gacacggtct gcaactgaag atggccaggc 2107981 accgcctgag atggtgccga tattcaccgg taccggtatt gggatattgt catacagcgg 2108041 atctgaaatt ctcgcattgc ggactttctc cagctcttgt atcgctgtga taacgtgcat 2108101 gcttttttca atcgcgctta ccccttcata gcgtgtgccc ccatgtgcgg ataatccctt 2108161 cacagtgatc cgaaaccaca tcgaaccctg ctgcttaata aatagtttca tattcgtcgg 2108221 ttcaggaatc agcgccccgt cagcacgata gcctctcatg atggcggaaa gtgtaccggc 2108281 gccgccgcac tcttcatcta caacactctg aaacaataca tctcccttca gtttgacatc 2108341 gcaggcgtgc agggcttcta aagcaaaaag aagggctgta ttgcctccct tcatatccgt 2108401 tgagccgcgg ccgtatattt taccgttttc ttcgacagct tgatacggtt catacttcca 2108461 atcctttacg cttccttcag gcacaacatc gatatggccg ttcaaaatca gggacctgcc 2108521 tccgccggct cccgtttttt tagccacgat attcgggctc tcatgaaaat cggatcggtt 2108581 agatttaaag tagggatgct gttttaattg ctttatgctt ggctcccata catcaatgtc 2108641 catatgaaat tgccgcagct tttcaagcac aacagcttgg gcgttaaact ctgaccccaa 2108701 tgtgcttttt tccccaatca gccttttgag aagacgaatg gctttggccg aatgctgatc 2108761 aagccactcg attacttttc tttcaatgtc ttgcatcctc attccccctc ttaagaaaaa 2108821 ggcatatcta ttttgatttc agcttctgtc agcctcgtca cctcatcgat tgtcgagcca 2108881 ttcatcagct cttttaaaat gaagtgatgg ctatcgacct caagaaccgc tttttcggta 2108941 ataatcaaat ctacacagcc tgcagcagtt aatggcagcg tacatctttc tgttaattta 2109001 ggccttccct tttgatctgt atgactcatg acgacaacca cttttttcgc tttttgggca 2109061 agctccatcg ccccgcccat accaggcacc ttttttcccg gaacaagcca atttgccaaa 2109121 tctcctgatt ggctcacctg cagggcgcct aaaatcgtaa tgtcaatttt gccttttctg 2109181 atcatcgcaa aagacatggt tgtatcaaaa taagaagccc cttttacagc gcggacagga 2109241 tatcccgcgg cgttgcataa atgcgcatcc tcttctccct tttcgggact ttctccaatg 2109301 ccaaggacac cgttttccgc ttgaaacatg acctgcatgt caggcttcaa aaagttcggt 2109361 accaaggaag ggataccgat accgagattc acaatcatgc cctgcttaat ttcagtagca 2109421 gcgcgttttg caatctgttc tctttctgct actcccaagc ccatttccac ttcactccct 2109481 cgcttcgtac aaccccctca acaaaaaccc ccggtgtgac aatcatttct tcagaaatct 2109541 cccccatcgg aacgatacgc tcagcttcgg caaaggttct cctggcggcc attgccataa 2109601 gcgggttcat attgcgcgcg gttttgtcat acgttagatt gccgaattca tctgcaatgt 2109661 aagcattgat gaaagcaaaa tcagcagtca gcgcctcttc aatcaagtat cgttttcccg 2109721 ccactgttac gatgtccttt ttttcgcaaa ccatttgatt atcaatgccc acgtcggtta 2109781 aaataccgcc aagccccgct ccgccggcgc gaatccgttc cgcaagcgtt ccctgaggtg 2109841 aaaattgaac ctctaacgtc ccctctgtca tctgttttcc ggctactgga ttggaaccga 2109901 tatgcgaggc gatcagggtt ttgacccgtt gattaacaat aagcgggccg attccgatat 2109961 ccgggaaacc ggcgtcattg caaatcacag tcaaatccgt tacaccgctg tccaatatcg 2110021 cttcaatcaa tgaaggaggc gacccgactc ccccaaaacc gccaaacatc agaaccgatc 2110081 catcccgaac atctgcaatt gctgtgtcaa tgctgattgc tttttgaaat ggcgccattt 2110141 aatgtcaatc cttttttaag tttttttcga ccgctgcaac tgtttctgaa aaaatagaga 2110201 taagctcttc catttcaccg tctgaaatag taaaaggagg agcaataatg acagcatctc 2110261 cttctccact gtctattcca gctttggaag gataaacaat cagcccgcgt tttttcgcct 2110321 cgctgacaat aagctgggtt atcgcctgct ctggcggaaa cactttcttc gttttttggt 2110381 ctgccacaaa ttcaatgcct aatagcagtc cttttccgcg cacctcacct ataatgccgc 2110441 tttgagatgc cgcctcatca agcttcttct tcagcacagc gccctttttt tctgattgtt 2110501 tgatcaagcc gtgctttaac acatatcgca aaacttcaag agcagctttg gctgaatagg 2110561 gatgtgcact atatgtgtga ccgctcataa tcacacctga cccttgtttt atggtttcaa 2110621 taatagaatc agatacgacg gcagcagcaa taggtgcata ccccgcaccg agtcccttcc 2110681 ccagtacagc aatatcaggt acggtatccc aatgctctgt cgcgagcatc cttcctgttc 2110741 tcccaagccc cgtcatcact tcatctgcaa taaaaagcac atcgtgtgtg cggcatacct 2110801 cacttaatct ctcataatat cccggaggcg gagtaatcgc tgctcctgca gcaccaataa 2110861 taggctcagc cacaaagccg gcgatgaatt ggcttccgat tcttttaatc atggtgtcca 2110921 gttcatcagc tgcagtctga acaaagtctt cttccgtctc gtgattcagc cgataaatat 2110981 gtggagctga gatagctgga taccgctcaa tgagatgggt gaaccggtat ctcctttcat 2111041 aaaaaccaga caatgaaagc gctcccaaag ttattccgtg gtaactgctc catcgagaca 2111101 aaaagatgga tttttgtgtt tgcttttttt cctgccaata ctgaatggcg attttcatag 2111161 ctgtttctat cgcttctgat ccgctgttga caaaaaaaga ccaattcaca tctccgggca 2111221 gctcctgtgc caagagagcg gctaattgct cggcgggctc actcgtaaac tgtgagcggt 2111281 aagcaaaaga cacctgatca agctgttctt tcagcttctc agtcacatca cgaactccgt 2111341 ggccgatatt acatgtcacc gcacctgacg agccgtcgag atattttttt ccggtctgat 2111401 cataaacata tgaacccttc gcataactga caaccggata ggccgagcta agctctggct 2111461 taatcaaata actgctcatg ctcccacctc aaaacccctt ttaccatatt gtatgagtgt 2111521 ccaaatggcg gcatgacgtt ccccgcaaaa actttttcac ataaaaagag ccttcctaat 2111581 aaggaaggct cttttgaaat ttcagcatct agcaaataaa agcggctcca acaataatta 2111641 ataaaatgaa caagacaaca attaacacaa atgtatttgt cccgcagcca aatccgtaac 2111701 cgtacccaga gtatccatac atgctgtttt catcctttct tatcacgata tacgacattt 2111761 tatgcgggcc aagtcccaaa tggtttgtgc aaacgcctat ttcatgtaag gaaataatga 2111821 aatacagtat gcacccgctc atatttttta aacgtcagct tttcgtaaaa ctgagttgca 2111881 ccgtcagtgc ttgcagccac taagtaggct gcttccattc ctagtgattt ggcgatggac 2111941 agcatttctt tcactaagat actgccgtag cccttccttt gaaactgatc taaaattgcc 2112001 acttcttcga ttttagccgt tttctcttga tgatcgataa acagctcgcc gcacccaatg 2112061 ggaactttct gtgcctggtc gctgtaacaa acaacaagaa tgattatatc tgcttcatag 2112121 aaaggatatt ttctttttaa tttttgttca gcgattgctt ctccaatata aatggaatcg 2112181 taaattttca taatagaaga tccgtcgcta agactttttg ccgtccccca tgcggttaaa 2112241 ggatgtccca tctgcccctt ccagtcacta agcttcatgt catatagtag ctcatcctcg 2112301 acgacaaaac cgctttttac aagtgactgc ttcaaaccga gcggaaaaac atgctgcggc 2112361 gacgctttta aatggagata attcgcatca agcagctttg gtacggaggg taaaaagtta 2112421 agtaaccgct ccaatggaaa cgtatcatgg agctgaacaa agttatgaga aaaaatttgc 2112481 ggaagctgcg gatctctgta tacgctgtaa tgatcaaacg atgccgattc agacgttaac 2112541 aatatatatt gatgttccgt ttttgaataa tgtcctgtca tgaacgtctc ctttttatga 2112601 cctatacctt tactctgttg caatattcaa tttctttata atctcatcgt acaccggata 2112661 aaacggcttt ccaattggaa attgctgaat atttcggaaa gaagcggaga ttggcttctg 2112721 atgtaaaaaa aacttccttg ttacttgttc actaatcggg tgaaagacgc cgtttagaaa 2112781 caaaaacggc tcgcgttcga tgaaaaacag acgtcggcca ggcggatttt tgatcaattc 2112841 agatcgtttc cacgtaatcg gcggcccttc cggaagcgtc tccatctctt cttttccaat 2112901 tgtcactatg tcttttcttt gaaattgata aaattgaaac gcatactggt ccacaattcg 2112961 cctttttttt ccggcttcga tataaaatat tgcaggatgg tcagcttcct ttactaaaat 2113021 ataattcgga atgtttaaaa ttttgccaat cctatattgg aataaatatg ggtctggaac 2113081 agcgacagtc cgatttagat acaaaaaacc ccacttttct ccaacaggat gccttacacc 2113141 ctgatcaaaa aaatacacat tttgatctga accttttaca aaagagccgt caatcaaatc 2113201 ggcgggcaga aaccgatatg cattttgaaa tgaatctggg gttttatagg ttgtgtctaa 2113261 tacttcattt atcggcagaa atggggtaaa gttgttgagt ctcgcccaaa aaattgcgtc 2113321 gccatgattc caatgcttca tatcatcatc ccagtagcct ccaaatttat ggtgaatgag 2113381 attaagtaac gaacggcgat gcataactga gcaatgatca acttgaaaag cggcctgatc 2113441 aagcactgca ttggcatttc tgtagaaatg tgagatttcc tctccccttt cgtttacatg 2113501 tacaactttt tgttttgaat agaccgcctg cgcttcaggc ttatgtgaaa actcttgcac 2113561 catacggctc agccgctcag gatgataaac agtgtcgtca gtaagatagg aaatgtaatc 2113621 gccgtctgca aatgggagcg cactgttaat taatgtggca taacgggctg tttttaatcg 2113681 atctgcagga tgcacgaaac tgttatgata ttgaatgcgc cggtcatgga gatacttgtg 2113741 aatcaccgca gttgtttctg cattcgaatg atcatccatg ataaaaagct cccaaagatc 2113801 atgcgtttgc tgtatcacgc tttcgatcgc tttttgcaaa taatcgggtt tgttgtaact 2113861 tgttaaaata atagacactt tctctcccat ctataccgcc tcccgccgtc aaacataaaa 2113921 acggctccgc agcaagcaga gcctctgtca tcatttaaaa agcaccccag cttacaacac 2113981 ttgagagtga aacatgagat ctcgtgttat ttaacgggtt ttggaaaata accaaatcag 2114041 tcagaacttc ttttacgatg acattttgaa gtgtatctcc gttgatcaaa ttgacttttg 2114101 aaaccggtac gcccagctct tttgcaaaaa caagctggcg tctgaggtca gatggatttc 2114161 cttcagaaga cgattgacgt atcagcagaa tcagcaaaag caaaataaaa tgcagatcat 2114221 cttggttttc ttctcgatcc acttgtttct ctaaatccaa atcatccctc tcccttatcc 2114281 ttatctctgt ttcacaatat gtgcgacttc gatttatggt ataggctatg tccactccat 2114341 taaaaaatca gcattttcct taaatagatg aaaaatagat caggtacggc gttcgactca 2114401 taccaaataa cagccggaag aatatgaata acgtgagttc actatcgaat aggaggtgtg 2114461 tgtaatgagc tctgaaaatg cacagttaaa aaaggattta attaaagccg ttttaagccc 2114521 tttatttcca actgcaacag aaggaggaga aaatatggat agtaatctta aagccttgct 2114581 tgatgctgcc atcgatcaaa aagtagatga aagtgaaacg gttacggcag aatctatttt 2114641 agacccttct cttccggcaa gatggatttt tgccagaatt acgccaggca ctacaatcag 2114701 cattgtgact gattcaggtg acatgatcgg accggttgtt ttcgttgctt tcgatcaggt 2114761 tcacgggatc gtatttgtaa cacaggaaag ctccgtcact ccggcaggcc aagctacaac 2114821 attaattgat gtagacaaag tagaaagcgt tacgttcttt tcataacatc cgatgaaagt 2114881 cttgtatatc cagtcgggat acggaggaat atacagttat tttgatcgct gggctgaaga 2114941 atgttttcag aacactcata cagagtatat gattgcagat aaacctgaag cagaatcttt 2115001 gatgaagatc gaagcgtttc agccggattt cacacttatg atggttggag accgcgttcc 2115061 tcacgactgg ctgacctggt taaagggtaa ggatatcccc gtgtatgttt ggctgaccga 2115121 agacccattt tatatggata tcagccttca ggtaattaag cttgctgacg ccatattaac 2115181 gatagaacaa aatgcagctc tctactatca agagctcggc taccagaacg tctattatgt 2115241 tccgatacca gttaaccatc ggctgtttaa aaaaatgggc accgaacatt cctatcattc 2115301 aaatctgtta atcatcggct atccttaccc taatcgggtt cagcttatga aagaagcggt 2115361 ccatctgcca ttcacggttc gggtaatcgg caaggaatgg ggaaaatatc tgcctaaaaa 2115421 agtgctcaaa cagccgcata ttgatgtcgt cagcacatgg gttccacccg aacaggccgt 2115481 tcattattat aatggggcag acatcgtaat taatgcgcat cgtccctatc attttgcttt 2115541 caaccaaaat actatgcgca tcaaaaatgc cagttttaat aaccgaacgt ttgatatcgc 2115601 tgcatgcgaa gcatttcaat taacagattt acccgcggcg catccttttt catccattat 2115661 ttcttatcac ggcatgaacg actttaagga aaaagccgct ttctatatca accaccctga 2115721 agaacggcaa aaagctgcag cagccaatta taaagagacc gtacccgcat ttacgtttga 2115781 tgagcttcct gcaaaactaa aagcgattca tctggcgctt tcttgaaaaa tcgttcattg 2115841 ctatgaacga tttttttatt catagaaaaa agcagctgca caagctgctt tctattctag 2115901 ccgtcagaac ggtctttcag cttcctcgga tttacctgtt tatgaagatc aggcatttcg 2115961 ccgagatgct gtgcaatttg ttcccacgat acaattttga aattttgatt gacggcttgt 2116021 ccgttatcaa tattttcgcc gtcctgcgcc acaaaaatcc cgtacggata ttttgggcca 2116081 agtccgaaac cgagaacatc aataccatcc gtgtcactag taccgtctat cttctcgcca 2116141 tctgtaatct caaagttggc tacatagcga tttttcccct gccgttcata cattgcatag 2116201 ctgttatttc cttgacttga agccatgaga tatcctttgc catttggtgc ataatagatt 2116261 gtcagtcctt caatatcagc tgtcaaatga tctcctgtcg cacggtcaac aacctgcccc 2116321 tttgaccctc cgccgggctc agcgttaaat ttccagatgg cctcatcttc ctctgctatg 2116381 tataggtttc cgtactcatc atccgcaaca aggccttcgg tctgagaatt caacttaaat 2116441 tcacgcacct ttttccctgt tacataaccc tttccaccat caacaatttc atactgctca 2116501 aattcccctt gtttgcctgt cactaatgcg taaaatgctc ctgttttctg gctgtgatac 2116561 aagctgaatc cataaacctc agaaatattg gtggaaatag gatggttcgg atctgtaatg 2116621 cttttcaatt ttcctttatc cccgtctatt gcatatactt caattgtatt ttttccttcg 2116681 gaccggttgg atgcggcagc aatatcaatt ttttcgccgt tcaatggaaa atcatagcgc 2116741 agatcgacat tattgagctt gccaaactca taagaatgaa gctgttttcc gtctaaatca 2116801 tacacaacga gccctgactt cttatttgtt gtaatcaact tgcttttttc cgggtgtttt 2116861 tcatgaaccc aaatggccgg gtcatctgct gcatcatcgc cagatgcgac cggatctgtc 2116921 tccgtgtgtg cagtcacttt gaaatgatgt tcctcattca cataatgagc cgacaccgag 2116981 gttgctgtca ggctaagcaa taaacccgcg gcagtgctta gcagcattgt ttttggaacc 2117041 ttcatttggt accctcctct tttatcacta acactactat tgtaaaatat atacaggtga 2117101 ttaccgtgag gaaaatgaac ctttttttat agggtttctg actcataaac aacttattcc 2117161 ccaaagaggt ggtgagatga ctttgccaga tttacttttg cggagcgaaa taaaaatatg 2117221 ttgaatattt agtacattat ttatttagtt ttgtttttcc ctagttacgt ccgtttttcc 2117281 attttctatt aaaaaagaac actttgtgac atgatcattc ccctaaattt tgttttattg 2117341 gttgctttca ttaattcgat tacaaagttg aacatatgat gcatggtaga gaaacgagag 2117401 ttggaggata agccatgcct aaacagcaaa cagcagaact aaaaccattt ttccataaca 2117461 aaacagtttt agtcactggc ggaacgggtt caatcgggag tcaaattgtc aaacgccttt 2117521 tgatgcttac acctaaacag gtgattgtat tcagcaaaga cgacagtaaa cagtatgtca 2117581 tgagccaaaa gtatgcggag gataagcggc tattatttgt acttggagat gtacgcgatc 2117641 acagaagggt gaatcaggtg atgaaaggcg tcgatatcgt ctttcacgcg gctgcgctga 2117701 aacaggttcc gacatgtgag gaccatccat ttgaagcgat ccagaccaat ctcatcggcg 2117761 gacaaaatgt ggtggaagct gccctttcac accgagtgca gcatgtcatt aatatcagta 2117821 cagataaagc tgtatctcct gtgaacacaa tgggtgccac caagctgtta tctgaaaagc 2117881 tgtttcatca agcaaaccgc cacgtccaaa acaaaggaac cttgttttgt tcggtccgct 2117941 ttggaaatgt tctcggttcc agaggttcgg tcatccccat attatttgaa cagatgatgg 2118001 agggtgaacc tctgaccatc acagacaaaa acatgaccag atttttcatg tcaatagacg 2118061 atgcagctac attgacatta caatcggctg ctattacaaa aggcggagaa acctttattt 2118121 tcaaaatgga atcactgaaa cttgaagaac tgattcatgg gtttgaagaa tatgcatcgc 2118181 agcacgggct cccgcggccg gctgcagtag aagtgggcaa gcgtccaggt gaaaagcttc 2118241 acgaagaatt aacatctcca catgaaattg aatcactgta tgaatggggc aacctttatg 2118301 cgatccttcc agagccggaa aaacatcctg actttcgcaa agtcaatctg cctgggtatc 2118361 aatcagatca agccccgctc attacgaaag aaagaattgc tcagattatt gaagaattgc 2118421 atcaagagaa aaaggcataa aaacaagcct gtctatccat taggcaggcc tgtttttaac 2118481 agtttattta ttaaagagat gcagatagct ttcgtatcct tcttctttta gcttatgctt 2118541 cggaacaaac cgcagcgctg ctgaatttat gcagtaacga agtccgtttg gccccggtcc 2118601 gtcattaaat acgtggccaa gatgagaatc agcagttcgg cttcttactt ctgtgcgaat 2118661 catgccgtgg ctcgtgtcca gtttttcttc cacttcttct tcaatcggct ttgtaaagct 2118721 tggccagccg cattgggaat caaatttatc tttggatgta aacaatggct tgcctgacac 2118781 aatgtctaca tacaaccctt cttccttatg atcccaatat tcattttgaa atggcggctc 2118841 cgtgccgtta ttttgcgtta cttcatattg catgcgattt aatgacttta ttttttcttc 2118901 tttattgtac gccatttatt tagcccccca atgctcgctg ataaatcccg ctcgtccgga 2118961 acctgtccgg tagcgctgat aatgtgctgg attcttttta taaaaatgct gatggtagcc 2119021 ttccgcttca tagaaaggtt cagcttttaa aatgtccgtt acaatcggat ctttaaagat 2119081 gccgctttcc gccagacgtt gcttggaagc ttccgcaagc tccttttgtt tatcattatg 2119141 ataaaaaatg gctgcgcgat aggaactgcc gcgatcagca aattgccctc cggcatctgt 2119201 cggatcgatt tgctgccaaa ataattcaag cagtttttca taagggaata catcaggatg 2119261 aaacgtgatt tgaacggctt cacgatgtcc cgtcgtttca ctgcacacct cttcgtacgt 2119321 agggttttca gtatggccgc ctgtataccc ggacaccact ttttcaattc ccggctgttc 2119381 gtcaaaaggt ttaaccatac accaaaaaca gcctcctgca aatgtggcga tttctttttt 2119441 ttcagacata ctggtgcctc ctttgttaat acgtggtatt attatattat agcatgtaaa 2119501 aatagaatga aaatgattct gcttttcaat aaaatctata ggttttaagc aatatgctta 2119561 tgtaatggag gttcacaaat ttgaaagtaa gaacacagat gatgtacgat atggaaactt 2119621 tactccgtaa agtctttaaa caaatacgca atgaaatcaa tgaaatttta gataaagagc 2119681 tgtcgcggaa tgaattcacc attcttcgaa tccttagtga acaagggcct aaaaaagtca 2119741 ctgaatttgc gcctatttta gaggtatcgg caagccacat tacggctgtg accgatgcgc 2119801 tggtagaaaa ggaatggatt acgagaatca gatcgaagga agacagacgc atcatccgca 2119861 ttcatatcac tgaagcgggc gaaaaagtcc ttcagcactt taacgagaaa aaaacggaat 2119921 atttctttaa acgctttgac tgctacactg atgctgaact tgccacgtta atcgagctct 2119981 tcagcaaact tgataaaaaa cggtgaaaaa aagcacatac cgatatatag gtatgtgctt 2120041 ttcgcagtgc ttcacttatt tttcagtaaa cagcttcatt gctttccagc ggccatatct 2120101 ataatacaaa aatgccgcgc agctgctaaa taaaaaactc attccgattc caagcccgat 2120161 tcctttttgt ccaagccaag ctgaaaatag agctgtgaaa ggatacctca acacccaaaa 2120221 cgagatcaaa tttaatacca gaacctgcag catcgctccc gcggccctga cgattccgtt 2120281 cagcacaaaa ttaaccccaa taaaagggta gaaaaacgcg atccacttca aatattgttc 2120341 accaaatgcg accgcatcag gctcactgat aaataacctt atgaggtatt taccaaatac 2120401 ccaaatcata accgcaatca ccagcatgca ggaaataaca gctatcacac ctagccttgc 2120461 aattgttccc actctttttt cgtttccgat tccaatattt tgccctgcca tactattgac 2120521 ggccgtaccg gcagccattg ctggaagcgt gatgatgcta tcaagccgct gcaccgcgcc 2120581 aaagcctgat accacgtgat ccccgtatga gttaacaaca ctcataatcg ccatcatacc 2120641 gcctgtaatc accatcatct gcagacctgc cggaatcccg agtttcaaaa tcagcgcgga 2120701 ctcttcccac ttgggcattc tcggaatcga gaatggcaca agcttgtgtt tgatgacata 2120761 aaacaaccca tacaaaaacg caatgccctg tgacaaaatc gttgaataag ccgctcccgc 2120821 tattcccatg cggaacacag aaataaagag cggcgcaagc actgtattca gtacaacagc 2120881 aaacgcaata aaccggagag gtgtcttgct gtcgcccagc gcacgaagca cagtactgat 2120941 aaagttataa ccaaacaaaa ataaaatgcc gataaattga atctgtaaat acgtctcagc 2121001 aagcggtatc attgactccg gcgtttttag aagacgcagc aaaagctctg agagaaaaaa 2121061 accggccgcg ccgaatccga tgcttaggcc tgttaataaa acaacaaaag cgttaatata 2121121 cgacgccatt ccttttatat catcttttcc tttttgctga gataaaatgg ttaacgtcgc 2121181 attgttaagg cccaaaataa aagacagcac ggtcaaaaca atcgtgcttg ataccgcggc 2121241 tgccccaagg gcctttgccc ccagtaaatt gccgatccac aagctgtcta taaattgaaa 2121301 ggaaacctgc aatgcgtttc cgagcataat aggcattgaa aacagtacaa gctgtttcag 2121361 cacgttcccc tgtgtaaaat cgtatgcttt catcttttct ccttgtgttc tcaaattttc 2121421 ttcggaccac acgaaaaaag agacgttgtt tcatgtctct tttttcatga cttatcggtt 2121481 ttttttcggt ctcgcatacc gaatgtaaac accatcacac ttaggaacaa ggcacaatag 2121541 gaaacattca aatacatttg atccatatct tcagcagcca gatgatgata agcaagccag 2121601 ccgaagtaca gggaaaatgt aaaggataat aaactgaaat actggtaaat ccgtttcatt 2121661 ttcagtcacc tctattgttt aggatggtaa taggaaaact caatttcatc tttttctaaa 2121721 tttatcttat ccgctttgac atacattcca ttcgttaaag gcatttctga caaacgcact 2121781 tcaatgcttt tatctccggg gtgaacatgg acaaatgacg gcaattcata aaagctgtcc 2121841 atataattta acacaaagct aattggtata ctcaatttcc ctaacgaaaa tttcgtgaca 2121901 ttcagctcta catcaccgtt ttttttcacg gtcggctcaa aagcgataaa cgcatcaata 2121961 gacgtggaaa atgccttgat tttccctgcg acatgaacat catcatcaat ctctacttta 2122021 taatcaagct tgtttgatgc tttgtcgttt aaatatgagt taacaaacgc agctaatgat 2122081 tcttttgtgc ttgtcacttg aaatccatac tcgctctcag atgcatcttt cacctgagcc 2122141 tgttcccccg gaagcaaaac aagtgccaca aacccggcgg cgaggataaa attgattgca 2122201 agcaatataa aaaacagtcg cttccactta ttcatgctgt caccctactc tttcggtaat 2122261 ccttcttttt taatggcttg atagacgcgc tttgcgataa gagaataacc cgtaccatta 2122321 ggatgaaaat catcttcctc agaaattcgg ctgctgtcac ttttttgatt aaacaaatct 2122381 tcgatatgga cgatttttgc atgtttatct tttttcagct ctttttcagc aatatggttc 2122441 caatccgtga cgacaccatt tatttcattt agttctgata atgtaaacgt aaacggattg 2122501 tacatgctga cataaatcag ctcagcgtga tcattcagct cgcgaatttc agaaatgatt 2122561 ttttcaaagc gcttttcgta cggtttttcc gcttcctgaa acggttcaac ggttaattgc 2122621 agaaagtttt ggcgaaggat tttcatcaaa tcattaccgc caattgtaaa aaagacataa 2122681 tctgcgtcct ttatgccttt ttgaaccttt ttatctttta gtttttctaa taaatcatcc 2122741 gaacggttcc cttttacagc ataatttttc acgtcgaccg ttttgacttg tttatctgac 2122801 cggatagaat ccgccacctt gccgacatat ccctttccgt cgggatctcc gactccttct 2122861 gtcagcgaat ctccgacagc cgctatgaca atgtgttctt ttgttttcgt ttcatgggct 2122921 ttttgttttc cctcagatga tgtacgtatg ctcgtacacg cagtaagaag caaaatcaaa 2122981 ctggccatga ttgaaaaaat gcgcagcttc aatcttgttg ctccttccca ttctactagt 2123041 ggaaagtgta tcatgtttta gaagatttgc aaatgcctag tctcttagct tacttgagtg 2123101 tactggctga cttcacatcg gaaatgatat catcgtacgg tgtattctcc actccattgt 2123161 aatctttcag caccttaccg tccggaccta ccaaataaaa agaagattga tgaatcactt 2123221 ggtcctctcc ctccggcttc tttacgatcg ctttaaagct cttaagtgcg aactcctcaa 2123281 tctcactctg gctgtatccc gtgagaaaat cccagttatc aaaagataat ggataatttg 2123341 cggcaaattt cttcagctgt ttcggcttat cgttttctgg atcaacacta aatgatatga 2123401 tgcggacatc tatattttcg gctttcagtt ttttttgcag atcggtcata tgagcggtca 2123461 ttggcggaca tatagtttca caattggtaa aaataaaatc cgccagccat acttctcctt 2123521 ttaaactctc taaagaaacg ttcttgccgt cttggttttg aaatgtaaaa ggctccacct 2123581 cgtaattgag cggatcttta atctgctgtc ctccgcatgc acacaaaaac agaaaaatca 2123641 gcccagccgt taaccccttg ataaccttca tgacatccat cctttccagc cagcataaaa 2123701 acgctttcta aaaccgtcct tactgtccca tgtttgtatt cgatactgag caaaaaaaat 2123761 cctgcatgcc tccccattaa cgattacaaa ggagggcatg caggtaaaaa acggcatgtt 2123821 acgcgttgtg ctttaacacc tcttgatgaa atacagcctg ataatctgcc cacttcatcc 2123881 gccgcttcat ataatgtcgg aaagaataca cttttgccct gctgtttgat gaaaacactt 2123941 cttttaagta gaattgcaaa tggtgatgta acataaagaa atagtgctca tcttccttta 2124001 atacaggtat ttctgtcact ttcacctgaa tcccgtcacc gcgtttgaac tctaggcttt 2124061 tgagtaacaa gctatcaatc ctcttttttg tttttcttct attatatatg atgccagccg 2124121 ggctgtctgt cattttgcgc ggttgtgtaa aaaaattaga ttagcaaatg gaacaagtcc 2124181 tcatccttgt tcacctctac ataatgaaac ggttttttgt tcatccgttc aatcagcggc 2124241 ccataatcgg ctttgttctg cagctcgatg ccgacaagag caggtccatt gcttttatta 2124301 tttttcttcg tatattcaaa ccttgtaatg tcatcattcg gcccgaggac ttcgtcaaga 2124361 aattcgcgga gcgcccccgc tctttgtgga aaattgacga taaaataatg ctgaaggcct 2124421 tcaaaaatca aggaacgctc cttcatttcc tgcattcttc cgatatcgtt attgcccccg 2124481 cttaccacac acaccacgtt tttcccttta atttgatcct tgtacaaatc aagcgctgcg 2124541 acagaaagag ctccagccgg ttcagcaaca accgcacatt cgttatataa ttcaagaatg 2124601 gatgtacata cttttccttc aggcacaagg agaatgtcat caacgacagt ttccagcgtc 2124661 cggaaggttt cctcgccaat ttttttaaca gccgccccat ctacaaactt atcaatttta 2124721 tcaagtgtga cgacatgccc agctttgttt gattcaaagt aggatgccgc tcccgccggc 2124781 tcaacagcaa ttacctttgt atcaggagac acgtttttca aatatgtacc taccccagag 2124841 agaaggccgc cgcctccgac acttgcaaaa agaaaatgcg gttctgtatc aatgtcgttt 2124901 aaaatctcga ctgcgagcgt tccctgtccg gccatcacat ccggatcatc gaacggatgg 2124961 ataaacgtcc gagattccgc ctcacagcat tcagcagcgc ttttatacgc gtcgtcaaac 2125021 gtatcgcctg tcaaaataat atcgataaat ccttttccga atagttcaac ttgagatact 2125081 ttttgtctcg gtgtagtaga cggcataaaa attttcccgt gaatgccaag atgtttacac 2125141 gaaaatgcca caccttgagc gtggtttccg gcacttgcac acacaactcc gttctctgtc 2125201 tgctcgctgg aaagctgttt cattttatga taagcccctc tgagcttaaa agatctgaca 2125261 acttgcaagt cttcgcgttt taaatagata ttgcattcat atctctcaga aagtctgtca 2125321 ttcctctgca aaggtgtgtg aatgacaacg tcctttacgt tttggtgagc cttcaaaatg 2125381 tctttcactt ggatgagaga gttttcttta agcaacggtt tcatgtacag attcctttct 2125441 tgttttaaat ccctatttaa tatgccatta taacatgaat attcaaaaaa taagacaatt 2125501 atttttattt aataattaaa aaaatacaga ctatgtccac cacatcttgt ggtaacttct 2125561 gttcaaccat tatcctgcag agccaagaaa aaagatgatc gtaaaataaa gggtgttttc 2125621 aaccaaaagg catgatataa tgaaaccaat tagaaccaaa aggagccaat tgatgaatag 2125681 tgcaccaaaa ctcaatacat ttcaacatct aatcggagaa catcaaactt ttctggaagc 2125741 gaagcgaatc gccaagcagt tctcgttatc ggagcttcct gtcttaataa caggaaaaat 2125801 cggaacaggc aaaaatcact tcgcacatgc catacacttg gaatcttcga gaagcaatga 2125861 accgtttata agcgtcaatt gcagcaccca ttcggaagaa acccttattc atgagctttt 2125921 tggccctaac ggaaacacag gtgtttttca aaaagcggta cgaggaaccc tttttcttga 2125981 tgatgtatgg cgcatgcctg cttctgtaca agctcagctg ttaaaagcgc ttgattcaga 2126041 cacggagaaa ccgcgaatga tctgtgcttc tgcagaccga tccgtggaac atacattcag 2126101 gcaagactta ttctacagac tgaacatttt aacgctcaca ctgcccgaat tatcggaacg 2126161 aaaaagcgat attccgcttt tgacacagca ttttctctca aattctggtc agcaattgtt 2126221 aatcgatccc tccgtttttc ccgtgcttga gaagcatgca tttgaaggca atgtcaggga 2126281 attaaaaaac gctgcagatt atatggcggc agtatcaagc gggggaacga ttcagccata 2126341 tgacctgccg ccgtatatta gaggcacgat agacggaaaa acgtcgaaga aaaaagcgaa 2126401 actgcttact ttaatggaaa aagctgagtt tttgtttatt ttggaaacaa taaaagtatt 2126461 gaacgaaaaa ggagaacctg ccagcagacg gatcatttct gaacacagca aaaataccca 2126521 aacctcgtta actcctcagc aggtcagaag ccgtctcgac tatttggaga aaaaagatta 2126581 tgtcaccaaa agccgcggac gcgcaggcac aaaaattacc tttgagggct tgagctttat 2126641 agagacgtta aaaaatcaaa tgatctagcg atcgaaagga gaatgtactt gtttacaatc 2126701 aaagaagaga tcgccaatgc gattacacac ggcatcggtg tcctcttatc catcccagca 2126761 ttagtgtttc taatcatatt tgcggctaat tacgggtctg catgggacat tgtcagcttt 2126821 acaatattcg gtgtctctat gctgctgtta tatttgagct ccaccctgct tcacagcatc 2126881 acacataaaa aaacgaagga cattttggag attattgatc atagcgcaat ttacgtactc 2126941 atcgccggaa cctacacgcc ttttttgctt gggccgctga aaggcacact cggctttacc 2127001 ctgttggtta tcgtatggtc acttgcccta ggcggaatcg tttttaaaat tttctttgtg 2127061 aaacggttta tcctattgtc aaccttcgtg tatttagtca tggggtggct gatgattatt 2127121 gcagttaaac ctttatatgc ttcactgagc ggagcgggat tcagcctcct ttttctcggc 2127181 ggcattttat actctgtcgg aaccatcttt tacatttgga aaaagatccc cttccatcac 2127241 gccatttggc acagctttgt attgggcggg agcgctgcca tgtttttctg cgtgctcttc 2127301 tattgtgtaa aggtgccttt cctttcgtaa cagtaacaga aaagcgcagt cttcacgact 2127361 gcgctttttt atgcacgtaa ttgtttttca ttggcaggta tataagcttt tgaaaaggac 2127421 aattcaatgt ctgccggttt taagcgttta aaaaacgagc cattttgcat gttatctgtt 2127481 cctttcgttt ccaccatcac caacggaaga tgatagcggg ccgcaagttc tacaggatca 2127541 atagaaccat ctagtgaaag aatcaggctt tgtccctttt ccagctgttt tgtcacatct 2127601 tcatatacct tttctgaatc cccgtctgaa atcacatcca tccgatccag ccattgcccg 2127661 ataaaaggca agcggaacac ttttgggtta gcgataaagc cggccggttc ctcaatatat 2127721 ccagcaatta aggccagttc agccaaacgc aaacggggat gcacatacaa aacaggaccg 2127781 tgtggtattg gctctggctg atggatcgtc acaactgaac cggagatgcc gatacagcct 2127841 tctaaaaacg cctttggctg ttcgtacaca agagccatct gttttttgta tgacagacgg 2127901 ggatcgagca ttgtttgatt aaataattgt ttcatatttt ttaacagcat atacacaata 2127961 taaaccacta gaaggctgta gcgaaccaat taaaatcctc ccgctttaga agaattcttt 2128021 ttttcataca ttagaaattc gtaatcatac gggttttttt cgtctttggt cccctgctca 2128081 gaagaaacca gcttccaatt ggattcatca aattcaggaa agtgacggtc accctcaaac 2128141 tcgtgatgaa ttttcgtcat atacagtctg tccgcataag ggaacaggtc cgtatagagc 2128201 tgagcccctc cgatcacaaa gcattcttca gggcctgaac aaatgtccag tacatccttt 2128261 aatgaactga caaccgtgca tccctgaaat tctgaatccg gcgctgaggt aacgacaata 2128321 tttttccgat ttggaagcgg acgtccgatc gattcaaatg ttttccggcc cataatgatt 2128381 gaatggcccg atgttatttt cttaaagtat gcaagatcat tgggcaaatg ccacggcaaa 2128441 tcattgtctt tgccgataag cctgttggca tccatcgcaa aaatgaatga aatcatacgc 2128501 tgaccgcccc ttttatatga ggatgcggat cataatcctc gatgataaag tcctcaaatg 2128561 caaagttaaa aatagaatca acctttctgg cgaaacgaag ctgcggaagc ggtctaacat 2128621 ctctttccag ctgcaaattg acttgttcaa tatgattttg gtaaatatga acatcaccaa 2128681 acgtatggat gaactcgccc ggttcaagcc cagtcacatg agcaatgatc atggttagga 2128741 gggcataaga tgcaatatta aacggcacac ctaagaaaac atcggcagag cgctgataca 2128801 gctgacagga cagcttgccg tcagacacat agaattggaa caggcaatgg cacggcggca 2128861 acgccatttt atcaatttca ccaacattcc aggcgctgac gattaagcgt ctggagttcg 2128921 gatttgtttt aatatcttca ataagacggg aaatttgatc aatggtttct ccatcagctc 2128981 cccgccaaga acgccattgg gagccatata caggtccaag ttcaccgttt tcatcagccc 2129041 actcattcca gattcgcact ccgttttcct gcagatagcg tacattcgta tctcctttta 2129101 agaaccacag cagttcatgc gcaattgatt taaagtggag ttttttagtg gtgagcatcg 2129161 gaaagccttc ccgtaaatta aatctcattt gatatccgaa agtgctgatt gttccggtcc 2129221 cagtccggtc tccctttttc tcaccatgct ctaaaacatg tctgcagaaa tccttatact 2129281 gtttcatttt tttcatcctt taaaagtagt cttctagtag tgtaacacaa taaaaaatca 2129341 tttctgaacc cagaaatgat ttttttatag tcagctgacg acaggctttt catcctgttc 2129401 tttttcttca tcttgcagat cctgatgcgt atgtgcaatt ctgctcgccg ctgctgcagc 2129461 aagagctgcc acaatatcat ccaaaaaggt gtgaataccg tctggacttt catcaagttc 2129521 cttaataatt ccaatcttct ctttatccaa ataaccgaaa ttggtcaaac cgatcgaccc 2129581 gtacacatta acgattgaaa gcgggataat ttcatctatg ccgtaaagcg gttcatccgt 2129641 ttcaacaagg tgctgcagcg gttcggggag aagtttctgt tctgcaagct gatcgagtgc 2129701 aaggcctgtc aaaacagcat gaataatttc acgtttgttc aggacttttt ctacattctc 2129761 catgcaaaca ctgagcggca gatttggatt gtatttttcc tgaagttttt gaacaatccg 2129821 tgcaatatct tctatcataa cgccccgttt gttcagcata tcctttgtta tatcgaccat 2129881 ttcattcatt gtgtactttt tcatgtctaa tggcatctcc tttaggcact catccagttg 2129941 ggaggcgtgt tgcggtccca gtaaatgctc ccaagctcat gatgtgattg aaatccatct 2130001 tctgctgtat gataatgaaa attaaaccag tagccgtcat gaggcgggtg gtctcttcgc 2130061 acatggaatc tgagaagatc ttctccagtt gtccgattgt aaacgttgaa aattttttcc 2130121 gttttgcccg ctgaaggcat gcttgagatc acaacatctt ggtacgcctc atcatcttgc 2130181 aatgtcgcta aataatcact aatcacattt tcgatttttg gcaggatctc tttccgatag 2130241 tcatcctcaa tgacaggagc gattctgctg ccgaatttta aaaaggactg atcctcagcg 2130301 ctgtcaagga gctgttcctt gtacgattga aaaagcagtt caggatctcg cctgtcatcc 2130361 gactcatcat cgtacaggtc atgctcatca taaaaagcgg tgtaatcatt ctgctcaaga 2130421 ctgctcggct gtccggaagg cttgtccgcc ataagggcag ccggaggaga tacgagcccg 2130481 aacgttacaa tggtaaataa aaccacaagg gtctttctca tccacaattt catgactgct 2130541 tattcctctc tattttattg tcatgtttct cttattttag cacatccaaa acatgcaagt 2130601 catgtactat atgaaactga tatgcaaatt aggagattcg ttgctatgca ctttgtgtaa 2130661 aaacgcttac aatatttcat gaaaggaggc tttccgcatg attgacgctc tgtttgccac 2130721 agtttcactc ttaacattat tatactttgt cgtcatggag gtcaccgatt aacagaaagc 2130781 ccgtgatatg aatcacgggc ttgtttgaat gacgccataa tggaacagtg ctgtttttct 2130841 tttcatgacg ttaaaaccaa actgttcaaa ccgcgggctt ttccagtggt cttttagcac 2130901 aacgcttttt ctggcgactc gtaccgcttc attgatacat ccttcgtgca aaacggaatc 2130961 ctctgccaaa tcacgtaaag gcgcgatgcc gtcagaggtt tctacaggtt catgaaacat 2131021 tggatcgaaa taaaccacat caacagagtt gtcagggagc tgcttgatgt gttcaaagca 2131081 atcaccattc ttcacctgga ttcttctcat cgcagcttga agctcttcta tacccgtttc 2131141 ccatgaatgc agccccgtcc tcactaaaac agacacaaga tggttttttt caatcccaac 2131201 aacagaaccc gtttcgccta ctgccatact tgcgataatg gcatctgacc ccaacccgag 2131261 tgtgcaatct aaaaacgtat ccccttcaga taagccggca gcccgaagca taggttcttt 2131321 ctccccctgt aagaagcgtt tggctctgaa catcgctgta ttcggatgaa aaaagaattt 2131381 ggcaccttgt ttcgtataca gctcaaaccg ctctttgccg accacaagca aatcacgttc 2131441 agctgatttc agcaggtgct caaccgtttg tttattccgg ccgcagtatg gcatatttag 2131501 ctctttagaa agctgctttg cagtttttat ggtgtgttca gacggtctat agcttgttgt 2131561 tatcatcttc tgtactccca aaaagaaaat gcccggagaa cgggcattta gcagtgcgca 2131621 tcgaaggcag cagtcagatt tttcatgatt tcttccatat cgtgtccttc aatttcatga 2131681 cgcggaataa aatgtacgac ttctttgcct ttcaaaagag ccattgatgg tgaagaaggc 2131741 tcctggccag taaaatactc acgcattttc gcagtagctt ctttatcttg gcccgcaaat 2131801 acagtcaccg tattgtcagg tgttttgtca ttctggagga ctgcctgtgt agccgcagga 2131861 cgcgcaaggc ctgccgcgca gccgcataca gagttaacga ctacaagagt tgtgccctct 2131921 gccttttcca taaagttttc tacttcttcc gctgttgtta actcttcaaa acctgctcca 2131981 gtcagctcgc ggcgcatcgg tacgacaagc tggcgcatgt attcttcata agccattgac 2132041 ataaaaaaag ccccctctag tatccttcat ctgaagtaaa ggatactata gagagggccg 2132101 gatttcaaat gttcacgcct taaaataaaa gaaagtgtcc ccagctatct agattttcat 2132161 aataccgccg gtgttggcac ttgtcacaag tttagaataa cgtgccaggt agccggtttt 2132221 cactttcggt tcaaaacctt tccagttcgc ttttcgtttt tcccactctt cttctggcac 2132281 ttgtacatcc aagatgcgtt tttcaatatc aacgataata tggtctccgt tttcaacaaa 2132341 ggcaagcggc ccgccctcag cggcctcagg tgatacgtgg ccgattgaga ggccacggga 2132401 ggctccggaa aaacgtccgt ccgtaatcaa tgccactttt ggcccgagtc ccattccaac 2132461 gatttgggat gttggcgcca gcatttccgg catgccaggt ccgccttttg gcccttcgta 2132521 tctgatgatg acaacgtcgc cttcttttac ttttcggttg ataatgccgt caagcgcctc 2132581 gtcctgagaa tcgaatacga cagccggccc ttcgtgtctt gtaatcccat tctgtacgcc 2132641 gcctgtttta atgatagcgc cgtccggagc tagattaccg aataaaacag caaggcctcc 2132701 cttttcagtg aatggttgat ccagcgggtg aatgacgtca taatccttta cttcatgtcc 2132761 ggcaatggtt tctccaagag tttttcctgt aacagtcagc gcatctaaat gaagcgctcc 2132821 ttctttcttc gaaagctcat tcagagccgc tgaaacgccg cccgcttcgt gaagatcttc 2132881 aataaacaca tccgatgcag gcgccagctt agccaagtgc ggcacgcgct cagcgacttc 2132941 gttaatgcgt tctaaagagt attcaacgcc ggcttcgttt gcaagggcaa gggtatgaag 2133001 aacggtattt gtagaacctc cgagcgccat atcgagtgca aacgcgttat caatcgcttt 2133061 tactgtaaca atatcacgcg gtttgatatc tttgcgaatc gtttccatta attgcgcagc 2133121 cgattttctc acaaactctt tgcgttccgg agatgttgcc agaatggttc cattacccgg 2133181 caaagcaaga ccaagtgctt ctgacagaca gttcattgag ttcgccgtaa acatgcctga 2133241 gcaagacccg cacgttgggc atccgaactg ctctagttct tgaagctcgt tttcgttgat 2133301 tttccctgct tggtaggcgc ctaccccttc gaatactgag gaaagggaga tttttcgccc 2133361 gtcacttgtt cttcctgccg ccatcggtcc gccgctgaca aaaatcgtcg gaatgttgat 2133421 gcgcattgcc gccataagca ttcccggtgt gattttgtcg cagttcggaa tacagaccat 2133481 tccgtcaaac cagtgtgcgg atacaaccgt ttccacagag tctgcgataa tttcacggct 2133541 tggcagcgaa tatctcatac cgatatgccc cattgcgatg ccatcatcta ccccaatggt 2133601 attaaattca aacggaacgc cccctgcttc tctgattgct tcttttacga ttttcccaaa 2133661 ctcctgcaag tgaacatgac cgggaacgat atcaatgtat gaattacaca ccgcaataaa 2133721 cggcttgccg aaatcctctt cttttacccc tgctgcacga agcaaactgc ggtgcggagc 2133781 tctatcgatt ccttgtgtga tcatattact gcgtaattct gccatggtga tcctcctaaa 2133841 ttctttcaat tgtttgattg gattttattt tgacaatttt cagtttattt atgggctgtt 2133901 tttgcaaata agataaatac aggccgccct caccttgttt tgttctttcg tgtttttata 2133961 tttatatagc tttctttcga tttgaaccct ccaactatta atattgttac ttactataaa 2134021 tagttttcgg atatttttca acaatattcg aaataatttt tataaaaagt gaattcacat 2134081 aaaaaaggtg catgatctgc acctttttta tctttattcg cctttttttc tgctttccgt 2134141 catttgtttc caaacagaac cttttgcttc ttctccatgc tcaatacgtt caagcgccat 2134201 tttgacttga aggctgacct caaattcggg gtcatcttcg gcagcgcgca aagcttcaat 2134261 tgcactttca tcgccgactt cgtacaggaa catggcggca cgccagcgaa caagcttgct 2134321 ggagtcgctt aatgacttga tcatagcagg aatggcttga ggatcgccga tatcagacag 2134381 gcagtctccg gccgttcttc tgactgatac agctttgtcc tcaagtgctt tatacaatag 2134441 aggaagaaca tcaggtgttt caatcattcc taagtacaca acagcctgtc ttctgatgga 2134501 cacctttgga tcatccaatg ccttctgtaa aaccgggata tcctcttctt tcggatccat 2134561 ctgttccaag tgtgcataac gctttttcca gtcctcatca tccagcatat caagcgttac 2134621 tttatacgct ttgcgctgta cagcttgttt tgcttcgccc tttccttgag cggctgcttc 2134681 agtcagtcgt ttcagccgtt catcactgta tgccgcttga agctcttctg tcacatcatg 2134741 gccgatttca tcaaagtcac cgaatctgac accttgttct ttccaagccc gctcaaacac 2134801 aacattggaa gcttcagatc taagttttaa gatcgcctgc tgaaagcgtt caggtaagcc 2134861 gaagcgttct tcccgctctc catcggttaa tttaacttgc ataggaatgc cgctgaacat 2134921 ctgcacaaaa acttttacct ctccaaaaga ttcttgatca gaacgatttt cttctgcgct 2134981 ttcagcactt tccatcccaa atgcagtgcg gacttgcggt aaaatgtctt tccagtcgta 2135041 tcttgcattc cgttcaacag caagaaaatc tgcgacgtga tatacccctt taactccatc 2135101 tattttaagg atttccgcta taacaagcgg tgcgccttct gcttgctcag gtttatagtt 2135161 attgcttttg cccgccggaa gctcttccgt taagatgact ttcattgtat tcgggcttgg 2135221 tgtaggttca attgatttta tcttcatgat cgtcctccta tagcatatct gtgacttatt 2135281 ctatcatagt cgctccaagc cttctattac gacgtttcgg catcaatccc gggtatgtct 2135341 ttttctaatt ggcggacaaa ttgaagcata aaattgtgtc tttcttctgc cagttcccgt 2135401 gcagtgtctg tattcatcat atctttcagc cgcagcagct tatgaaaaaa atgagcgtag 2135461 gcgctttgct catctccata aaggccatgc ccttttgcgc ccgcaaacat gaaagctctc 2135521 gcaatgccga cagcaccaat cgcatcaagt ctgtcagcat cctgtacagc ttttccttca 2135581 attgagagcg gctccttcgc caatttcccc ctgtcccgaa aggacatcct tgttataata 2135641 tgaatcaccc tgtcagcatt ctcttttcct actccgaaaa aaacgagctg atcatatact 2135701 tcgctcacag aaagcctgac cgtgtcaggc agcttcacat caattaaatc atgaaccaaa 2135761 gccgccgttt caacaatgaa caaatccgct ttttcctttt ctccaatata cgctgcaaga 2135821 tctgctactc ttgatacatg atgccagtca tgtccagagc tttcgtcagt caggatagat 2135881 tgaacccatg tcctgatttg ctctgcctgc ttcaattcct tcacaaaaac accctctttt 2135941 tattgctcta atagcttcac gatatcgtct tccaactctt tcggatttgt atttggtgaa 2136001 taacggccaa cgatttctcc atttctatcc actataaatt tcgtgaaatt ccacttgatc 2136061 gccttagttc ccagcatccc tttcgcatgt tctgtcaaat acacaaacag cgggtgggcg 2136121 tttttcccgt ttacatccac ttttgaaaac ataggaaatg taacaccgta atttgtttca 2136181 caaaattcct gtatgtcagc ctcttcacca ggctcttggt tcatgaattg attgcagggg 2136241 aaccctaaga tctccagccc ctcctgctga tatgtatcat ataattcctg cagctgcttc 2136301 aattgggaag taaaaccgca cttacttgct gtattcacga tcatcagtac ctttcccgcg 2136361 aaaggctgaa gtgtcatgtc tttccctgtg attgtacgta ccttcatatg ataaatagac 2136421 atgtaagtcc ctcctatgtc cttggtgctg attattttac cttttttaaa tcgcaattca 2136481 aaatgtaaac atcaattaag aactcataag aaacctaacg atatgagcgt cagttcatta 2136541 tcaattcata tggctcgttt tttatcttat cattctataa aacattacaa ttccctctta 2136601 catctttgaa aatcatttta ctgtgaaacc aaaaggcgtg tcagtgcgtt ttatttaaag 2136661 agttttctgt tgtttccccc tcaacacgta tagatagatt gaaaattggc gtgaaaattc 2136721 ctataatgaa gaaaattaaa cggggaaata atggaggtgg cacgttgcct attaatatac 2136781 caacacacct gccggcaaaa caggtgcttg aaagtgaaca tatatttgta atggatgaaa 2136841 gcagagcatt tcatcaggat atccggccgc aaaaaattat tatattaaat ttgatgccga 2136901 aaaaaatcca aacagagact cagcttctca gattgcttgg aaattcgcct ttacaggttc 2136961 atttcacatt tttaatccca agcacacaca cgccgaaaaa tactgcgaga gaacaccttg 2137021 acgaatttta cacgactttt tccaatatcc gtcacaagag gtttgacggc atgattatca 2137081 ccggtgcgcc gatcgagcat ttggcgtttg aagaggtttc atattgggaa gagctcaagg 2137141 aaatcatgga gtggagcaaa acaaatgtca cttcaacctt gcatatttgc tggggtgctc 2137201 aagcaggttt gtattaccat tacggtgtgg aaaaaattca aatgccgaaa aaaatcttcg 2137261 gtgtgttcga acataccgtt ctttcaaaac acgaaagatt ggtaagaggt tttgacgagc 2137321 tatactacgt gccgcattcc cggcatacag atataaatat ggaacagctt caagcagtgc 2137381 ccgagttaaa cattcttacc gcatcaaagg aagccggggt ttgcttaatt gtgtctaaag 2137441 acgaaaaaca agtctttttg acagggcacc ctgaatatga tacaaatacg cttcttcaag 2137501 agtatgaaag agatttggaa cgaaaccttt ctactgtcga ggcccctaaa cattattttg 2137561 caaaaggcag caacgagcca gtgaatcgct ggaaagcgca tgccacatta ttgtttatga 2137621 attggctgaa ttattacgtt taccaagaaa ctccttatga atgggactaa tttttctttt 2137681 tttagtgata cgctgagcaa aaaatatgat aaaatacatc tgattcagtc tgcgtataac 2137741 aaaaatttaa aatactggaa tccaaatcat ttaaaattag cttaactttt tcactgcatt 2137801 aataattcga ttatgtattt gtgttatgtt tatgtataga caataactcc ttacgatgca 2137861 tgaagcttgc ttgttgttga ttacattgag gtgaatttac ttgaatacca ataaaagagt 2137921 attaattttg actgcaaatt acggaaatgg acatgtgcag gtagccaaaa cactttatga 2137981 acaatgtgta cggctcggct ttcagcatgt aacagtttct aatttgtacc aagagtcaaa 2138041 tccgattgtt tcagaggtaa ctcaatacct ttatttaaaa agcttctcaa tcgggaaaca 2138101 gttttatcgt ttgttttatt acggagttga caaaatctat aataaacgta aattcaatat 2138161 ttactttaaa atgggtaata aaagattggg cgaacttgtc gatgaacatc agcccgatat 2138221 tattattaat acatttccga tgatcgtcgt gccggaatac agacgccgaa ctggaagagt 2138281 cattcctacc ttcaacgtta tgactgattt ttgtcttcat aaaatttggg ttcacgaaaa 2138341 cgtggataaa tattatgtgg cgacagatta cgtgaaggaa aaactgctgg agatcggcac 2138401 tcatccaagc aatgtaaaaa tcacaggaat tccaatcagg ccgcaatttg aagaatccat 2138461 gcctgttggc ccgatatata aaaagtacaa tctttcacca aacaaaaaag tgcttctgat 2138521 catggcaggt gctcacggtg tattaaagaa cgtaaaagag ctgtgcgaaa accttgtcaa 2138581 ggatgaccaa gtgcaagtag ttgtcgtgtg cgggaaaaat acggctttaa aagaatcttt 2138641 gagtgcgctt gaagcggaaa atggtgacaa attaaaagtt ctgggctatg tggagcgcat 2138701 tgatgagcta tttcggatca cagattgcat gattaccaag cccggcggca ttactttgac 2138761 agaagccaca gccattggag tgcctgtcat tctgtacaaa cccgtgcctg gccaggaaaa 2138821 agaaaatgca aacttctttg aagaccgcgg agctgccatc gttgtgaacc gtcatgaaga 2138881 gattctcgag tcagtcactt cccttcttgc agatgaagat accttgcatc gcatgaagaa 2138941 aaacattaag gaccttcatt tagcaaactc ctctgaagtg attttagagg atatcctgaa 2139001 ggaatcagaa atgatgaccg ccaaacaaaa agccaaagtg ctatcgtaat ggcgtacttg 2139061 agagcatacg aaaatcgtgt gctcttttta tttatattca gccatcaata aaagcggtta 2139121 cattttttta tggaacttgc ccttcttttg aaaaataagc cgtttcgcaa cttgacgggt 2139181 gctcccagat ggtgtatagt tgaaccatca tttaacaatg aatcaaagtt agatgatgac 2139241 aaaatttttt ttagcacatg ggtgctacag tactaggagg aattaagcaa tatgcaaaac 2139301 ggtaaagtaa aatggttcaa caacgaaaaa ggattcggct tcattgaagt tgaaggcgga 2139361 gacgatgtat ttgttcactt cacagctatc gaaggagatg gatacaaatc attagaagaa 2139421 ggacaagaag tttcttttga aattgtcgaa ggtaatcgtg gacctcaagc ttctaatgtt 2139481 gtaaaactct aaactcaata catgatgatg agatgacaaa tagaggagag gcattcgcct 2139541 ctcctatttg attttcatct ggatttcaat cgccaaaatg ttttgtttac acctctgttc 2139601 aatctcttca acatactttt ccattgatgg ttttcctttt ttcgcgatat cggccagttc 2139661 ttctaaatca ctgtatattt ctataaatgt tttgtgaagg atcaacttca agtctttatc 2139721 atccatagct gcgttcccct tctctatcaa gatacctcaa atagtaaaac ggtcctattt 2139781 attctggttc aatagttata tcggcttatt tttattttct tttctatttt ggtacataaa 2139841 tttcaaaaaa actctgcaaa ataatggcgg aggtgttttt tgtgacttca gaatttcata 2139901 atgaggatca gaccggcttt acggataagc ggcagctgga actagcggtg gaaacagcgc 2139961 agaaaacaac aggagccgcg acgagaggcc aaagcaaaac attagtcgac tctgcatacc 2140021 aagccattga ggatgctaga gaactgtcac aatctgaaga gctggcagct ctcgatgatc 2140081 ctgaatttgt aaagcagcaa cagcagctgc tagatgacag cgagcatcag ctggatgaat 2140141 tcaaagaata aaaaccgcag cttctgcggt ttttattttt agtgattggt taagacatct 2140201 ccgtattgtt tcaacttttc accaaccgta catttattga tacaaaatga atgcgcataa 2140261 gttttgccaa attctttgcg aaactgcttc ttaataaaac agtccttgca atattcatcg 2140321 tgcagttctg tcagttcttt aaagatcatt ttcttatcca atatcgtcat ctccgttacg 2140381 gtctaatttc gtgtggcttt ctacgaattg atgggataga atttttttag cgaggccgtc 2140441 agcttcctga ttgtcttttc gttgtattgt ttcgtaggtt ggagtaagct tcagcgattc 2140501 aaggagtgct tctattttgt ccagccattc attatgagat ggatcataac aaggccagct 2140561 gccgtcaagc tgattcagca caacaagcga gtcccctttg attgtaattg aatttctgct 2140621 tgccccaagc tctcttactt ctcttattgc ttcataaagc gctgcgtatt cagcttcatt 2140681 attggttttc agccggaagc ttttattttt tctcaagcga tgccgggttc ctcccaatga 2140741 ataatagatg acgatcccga gaccggccag ttcgctctct ttatcgaaac tgccgtcaaa 2140801 ataaacagta atgtcatcag gctcttgagc aagctcctct gtcagctttt ccaattcctt 2140861 cagcgtccag ctgccgcctt tctcgtcttc gaactctagc tccttcatgt atggaaaacg 2140921 gccaagttct ctggcgaacg tacgtgcctg ctgtgctgtc agccagtctt cgctaaaaaa 2140981 tgagacggat cccgttcctt ttgcttctat tttcaaatgc ggtctgagct tcattacaat 2141041 caccttacca ttcattagtt gccgggctta tgctataatc aaaccaatct taccccggaa 2141101 aggaagcttt ttcatcttgt ttaataattc gttttggatc ttttttgcga tcattcattt 2141161 tatcattgtt cttttatttt ataaaggatt tggcaaaatg ggactgtttg tttggatcgg 2141221 ttttgcgaca gtctgcgcca acctccaagt cgtcaaaaca gtcgaactgt ttggcttaac 2141281 agcgacactc gggaatgtga tgtatggcac aatctttttt gcgacagatg tgctgaatga 2141341 aaaatacgga ccagctgaag ccagaaaagc ggtatggctc ggattctcaa cgctcctgac 2141401 gctgacattt gtcatgcagg gcgtgctgct tttcgaaccg gcttccagcg acatatcaca 2141461 aacagcgctg gaaacgatct tcggattcct tccgcgagtt gcgttaggaa gtctgcttgc 2141521 ctttatcttc agccaaacgc tggatgttta tgtatattcg gcaattagaa ggatatttcc 2141581 ttctgatcgg cttttatggc tcagaaacgg cggcagtaca gcagtcagcc agttgtttga 2141641 tacattcata ttcactgcag tcgcctttct cggcatttat ccggcagacg tgtggcttca 2141701 tatttttatt tctacatatt tgattaagtt tgcggtatct ttaatttcat tgccttatgc 2141761 ctatgcagcc aaaaaaatga tacctaatga tgaaaggagt tcataatgcc tacagaaata 2141821 tatgtagacg gcgcaagcgc cggtaatcca gggccttccg gtatcggcat ttttatcaaa 2141881 catgagggaa aagcagaatc tttctctatt ccaatcggag tgcatacaaa ccaggaagcg 2141941 gaatttcttg cattaattga agggatgaag ctatgtgcaa cgcgcgggta tcaatcagtt 2142001 tcctttcgaa ccgattcaga tattgtggaa cgcgccactg agcttgaaat ggttaaaaat 2142061 ataacgtttc aaccgtttgt agaagagatc atccgattaa aagcggcatt ccctcttttt 2142121 ttcatcaaat ggataccggg caagcaaaac caaaaagccg atcttctggc aaaagaagcg 2142181 attcggctga atgaaaagaa ttaaatcttg atcattggtt catcctaatg gcgaggtgaa 2142241 ctaacatgaa aaagaaagat aaaggccggc tgaccggcgg tgttactccg caaggcgacc 2142301 tggaaggcaa tacacataat gaccctaaaa cagagcttga ggagagagca aaaaaaagca 2142361 atacaaaacg ctagagagga tctaaacgat ctctctagcg ttcagctttt caagcatacg 2142421 ctcaattcct ttaatttggt ggcggcgaag catgtcagcc gcctgctcca tttgcaaagt 2142481 aaataaagcg tctttcagtg tgcaggccag cggcactgag caatggattt ccgcaagctt 2142541 cctcgacatc tccaaatcgc ttaaaccttg ctgaattttt ccctgctgtc cttttggaag 2142601 aagagaaaga ttttccaata aacggtcaat cgtttcgtat tcacgaatca gtttgtaggc 2142661 tgttttttct ccaatgcctt tgactccggg atagttatca ctggaatcac ccataagcgc 2142721 tttaatatca atcaaagcct tcggcattac gcctgtttct tcataaaaag tctcttttgt 2142781 atagacttta taatttccga ttcctttttg aagcaaagca acgcttactt tatccgttaa 2142841 cagctgaagt aaatctctgt cccctgttac caccgtaatg tccgcttcat tcgcaaataa 2142901 atcggcaaga gtaccgatac agtcatccgc ttcatagccg gcaaagccaa tattcatgat 2142961 tccaagctct gcggctgctt cctttgccaa atcaaactgc ggaatcagct ccacaggcgg 2143021 cgcgctgcgg ttggccttat aatcttggaa caagtcattt cggtacgttt tgctccccat 2143081 gtcccagcag cagacgacgt gtgtcggctg gaatgtttcc acagctgtaa tcaaatgctt 2143141 taaaaagccg ttgacgccgt tcgtcggcac cccgctgtca tttatcataa agttgcgatg 2143201 tacggccgtg gcaaaaaagg cccggaataa aagagccatg ccgtcaacca gcaatagttt 2143261 attattattc atcaaataac tcccttttct ttcattcctt ctattttatc ataaagcagc 2143321 ccaaaaataa aaaacagtat ctctttaatt agagatactg tttgaatatt tatcaatcgt 2143381 tgtgtctttt gttgctggcg atcagctttt cagcttcgcg tcctgcgtaa gagtcaaaat 2143441 gggtttgaaa tccgtttttc tttttggcgt tgttattcgc ctgtgcattt ctgtttccga 2143501 gctttgttct gcccaacatg aatcccccct tacgtcggat gcatatagta tatgcttccg 2143561 gcaggaggtt cactcgcgac aggatcatcc agcttacatg cggcttacgt attctctgac 2143621 catttctttt gatacaagcc gtcttgtcgg gacgatgcct tttttagcga gctgattcat 2143681 ttgctcggta atttcattaa ttgcatctgt agtataaggc tcatcgtttc tgcatttagc 2143741 aacagcttct tcaatcgcca attcacgcat attttcaaga cgcataaatg ctttgatatg 2143801 ctcgtgctgt tttgatgaat gtgctgaaat tgctttatgt acctctgaca ttaatcgttc 2143861 atctcgcttt tttctattta gtctatcatg acttgaaata caagccaact gaattttaca 2143921 tttttattgt attgtctgaa tttttccagg agatgcacgc ctgatacgcc atttcaatct 2143981 ctttcgcatg ttccccttcc gcatatcctc ttaaatatgt ctctttttga tccgttattt 2144041 gcgcgattgc tttttcaccc atatcttcct gtaagcgtct gaggtgagca gtgtaatgag 2144101 atatcaggct ttcttcttca ttttttatcc atgcctctgt gattttcgta agtttcatcc 2144161 gtacagcttc gataaaggtc gcttttcctt tctgctcaaa aaactgcttc ggtgatttga 2144221 tctcttttag ttcctgctca aaagcacgtt cttctatttc cggttcaact tccttcaact 2144281 gtatgccgtt cgaatgctga tcacccgcat aaacggaaaa ataaccgtcc tcgtttaatg 2144341 ttttttgaaa atgatccagc cattcttcat tgatatgccg ttcgatgaaa ccgctcatgc 2144401 gaacatcaag cgttttgatt tcctgaatat attcaaatag atattcatgt aaggctgttg 2144461 tcatcgcttt actgacgttc tttttccaat ccccgttttg cagcccggga tgaaatgccg 2144521 attttaataa atcatttgca aaatatgata atcgctgtgc aatgtgatat agctgctctc 2144581 ttgtatcttt ttttactttt tcaatgatgg tttttgagtt ccgccgtttc tcgatatcgg 2144641 ccgctgtccg ctcaaatgac agcataaggc actgtttctg cgcttccttc tcttctcggg 2144701 actgatgctg ggattggtga agctgaaaaa cagtttcgca tagtttgtct gcctccgaac 2144761 tgagctgcgc tgctgacgct ttttttacat ccacttcgat aaaccggtct aagtgttttc 2144821 ttactttcga gaactgatta taaaatgact ccggttttcc caccagttcc tccttacttg 2144881 atacggtaaa gagctgcggc tcataaaccc cttcttttac aagctctgcg ctgacataat 2144941 cggtcactgt ttcgagctct gttttatctt ttgcaaggtc tgcagcatta ataataaaaa 2145001 acattttatc catgctgagc gattctttca caagtccaag ctttcgcaaa aatgaacggt 2145061 ctccttttga aaaagagtgc tgataataag tcatataaaa aaatgcatca gcatctttga 2145121 tatattggaa tgccagttct gtatgccgtt tattcatgct gctcgcgccg ggtgtatcaa 2145181 cgatcgtaat ccctttttca gtgagcgggc atgtatagta gaccgttacc tctttcacag 2145241 cacaggccgt tgtttcctct gctacatacg gctttaattc agagagcgga atcgttaatt 2145301 tcttctgttc ctgtatatac tgctgatact tctcgtatgc aagcaggaaa ttgctgatca 2145361 atttcacgtg ttcttcctgc agcctgtttt ttttgactgc cttttcccac ttctctgtga 2145421 aggaacggcc tgccggctcc tttggtattc cggtgagctg caaaatttca gccgttaagt 2145481 catcctctgt cttaaacact acattcgctg ttttgtttaa gttgccattg attggctttg 2145541 tgatcttgtt aattgtcgct gtggttggcg ttggtgagga tggcagcact ctttcgccga 2145601 caagcgcatt ggcaaatgat gatttccccg agctaaagcc tccaaaaaga gcgagtgtaa 2145661 atttccgttc ctcaagcctt ttcacccttt cacgaaacgc tgaagtttgc tttaacaaca 2145721 tgctgcattc gcctaaaatg tcagacaaag tgtaaaagcg tttgatttgg tcttgaagcg 2145781 gcatttcttg ttccattttg atttctgatt tcggcatcgg ctgcgccgtc agctggcttc 2145841 ggccttgttt ctgctctgga gccgccactc ttgttttctt cgatttaaac cattctgtgt 2145901 ctatatgcat tgggcatgcg gactcttctt cccaaatggc ccacaggcga tcggttttct 2145961 ctcgggcatt attctctaaa cgtgcctgtt cttgaagaaa gacaagtttt tctgattctt 2146021 ggacgagccg gtcgttaatt gtttgcacat ctttggaaac acgctctttc accatagcgg 2146081 agagcacctt tatgatgtct gcggcttctc ttttcgcctc tttccggatg agctctgcca 2146141 agtcttttgt atattgcaat acatattcag aggaaaaggc tgcaccatgc ttgaccgcgt 2146201 gttcaatgat gcttatatca agcggtgtgc gataggcctg aatcagcttt tcactttcag 2146261 cggtatagac atcaaatacc ttggcgagtt tatgaagcgt gtctatcata tgccaatccg 2146321 cttcggcctc tgttcgtttt gccacatcag agaaaaaagc attccgcctt ttatctcttt 2146381 cctgtgcagt tttcgcttta gaaaagaaaa agccggtttt aaaggaaggc tcttgtgatt 2146441 ctaaaaatgc agccgccaat tcacgcattt caaaaggcgt caggttggcg ttttttaaaa 2146501 tacgattgat ttcttcctgc atcctcttct ctgcctcagt catttgtttt tcggcctcat 2146561 ccaattgatc acgcagcgat tggaccagtc cagtatggat attaagctgt tcagcgaaac 2146621 tcggagcgcc tgtttcgtct ttcttcagca tttccgtatg ttcctttagc agattacgga 2146681 ctttttgttc ggttaaagcc tgcatattgc tttttgattg ctgttctatt ctgcttaact 2146741 cttctctcag ggcccccatc tgattgaacg ggtgatccgg ttctgttact gatgtaaaat 2146801 agagcgcttc ccttgaaatc ccttcattgc aaagcatctc ctctacctgc gcttgatagt 2146861 ctccaaattt cgtctccgtc tcatcatggc ggtcaatttg attgacgata aaatacacat 2146921 tcggaatgct ttcttttatt gatctgagaa actttacatt ttcctcagcg tgcacgtgat 2146981 tatagtgaac gacgtaaaac agcgcatccg cttggtgaag aatagaagca gccgatagaa 2147041 aatgcgcatc atctgttgaa tctatccctg gagtatcaat atacgcaacc ccggaatcga 2147101 tctcagtata cctgtcaaaa atttcgacgc tttcaatctg ttccccgtct ttacaatatt 2147161 gctgcacctt gtctttctgg taagtccctt ccagctcagc acacgctccg tctgttgtat 2147221 gaagccgaac tcgcttttcc ccgtttctga tcacaacaag gttagcgctt gtcggaatcg 2147281 ggcttgtcgg caaaatattc tccattaaca ggcagttcag cagtgacgat ttccccgctg 2147341 aataatgccc ggtaaacgcg atataaacct cttcatcagc cgcttttttc atgaccgcag 2147401 ccagtttagc agccctttgt tcatcttgat tctcaataaa ttgcttataa agttccccgg 2147461 ttttatgcaa aagctctttt ctgttttgat ctgtcataag tctgaacccc tttgtgccgt 2147521 ttcaattgtg aacctttttc gaaagatctg aattcattcc cttttcattt tacacaagaa 2147581 taaaccaaat ttctttagga gaatagaaaa aagccgccat tacggcagct tctataaaag 2147641 aaaatctgca acttttacaa gttccagatt catcaaacag atttattaga gattcctttt 2147701 aatacaaaac caattaatac actatatgta caaaccgctc caagcaaaaa cagcattgtc 2147761 atttgcttca ccatcctgat tgagaatctt tttcaaaccc attttaacat ggttgagaat 2147821 gattttcaat cgctatttta cgctgtattc ctgtaatgct ttgtcttctg cgcgaattct 2147881 gacgcttaac aacacggcat tgaaaatgga aaacagacac atggtgacgt atgcttgata 2147941 aagcagcgga atcagcaaaa tttcgaggat aacaacggca tagtttggat gtttcatcca 2148001 tttatatgga ccttttttta caagctctac acctggaaca acaaggattt tcgtattcca 2148061 atatgctcct aaggaacaaa gcgcccaata ccgtacgatc tgtacgctta aaatcactgc 2148121 agcgataccg agccaccagc tggacggctg tttattcatc agcagcacct cggcaattaa 2148181 ggacaggaaa aaaaggatat gcatcgtaat gatatacgga tagtggctct cgccaaattc 2148241 aattgctcct tgcttcttta ccttttgttc gttttgcctg gccactgcca tttctgctgc 2148301 tctttgaaca atgagaatgg cgatcaacaa ccaaaacatg agtcaggccc ccttttccca 2148361 gctgaataat agcaactctg atgagaaacc cggccctaat gcgccaatca gtcctcgttc 2148421 agcttccttt ttatgtccgt tctgcagatg gtctttgatc acatacaaga ttgtggctga 2148481 agacatattt ccgtgctttt gcaaaatgct ttgcgcagat gaaagctttt ctgacgacag 2148541 cccgagactt ttgatgtatg catcgatcac tttttttccg cctggatgcg ccaaaaaaac 2148601 actgatatca tggaatgaca gcttatgttt gtccaaaaaa atctgtacat ttgttttgag 2148661 ccatttttcc accaaggtcg gaatgtctcg tgagaaaatg actttgaatc cttgatcggt 2148721 aaagtcccag cccatgacat cttctgattg tttcatcaaa acagattggg cgtccattat 2148781 cttcggcgca agcttcagct ttgacaccct gcggtccgcc ttctctccgc ataataaagc 2148841 tgcggcaatg ccgtcaccaa aaagcgaggt gccgatcaga ttgctttttg ttttatcttc 2148901 cggctggaat gtcaggctgc acagctcggc agaaatgaca agcacaaaag cctcaggata 2148961 cgctttgcag tattcggctg cacgcgcaag tccgctggct cctcctgcac agccaagccc 2149021 ccaaatcgga atccgcttcg tatatggaga aaacggaagt tcattcataa gccgcgcctc 2149081 gatactcggt gtggaaagac ctgtactgga gacgaaaaaa acagcttcca ctttctcata 2149141 aggaatggct tcttgaaaaa attccggatg agagaggcac tcacgaacag ccgctctgct 2149201 gtgtttaagt gtttcttcta tgtatatttg atttttttct tcaaagctgt gcccctcttt 2149261 ataccattca atcggcttaa caaactgtct cgaatggatt tgcccgtttt taaaggagga 2149321 taacagcctg tcaatatcct taaaagaatg ctgaaacata tagcgggcga actcggccgc 2149381 tttctcttgg tttacattat acgcaggaag acttgttcca atggataaaa taaacgccat 2149441 gcgatcacct ctttgcatac attgtgccgc aacaatcttt tttatatgca aaaaaaactc 2149501 cgccgcggcg gagttagact gctgtttttt gttcagcgag gtcagcttct tgttctattt 2149561 ttttagcttt agaaaaaacg ttatatacaa tatttaagac gactgcagta aagctgcccg 2149621 ccacaatgcc attcgttgta agcagcgtta aggcactcgg aagctgtttg aaaatatccg 2149681 gcacaacggt cacaccgagc cccaatccca ctgagcaagc aacaatcagc agattttcct 2149741 gtttcgcaaa atcaatgcgg ctgagcattt taattccgta agcaatcacc attccaaaca 2149801 tcgccaccat tgcaccgccc aaaacagcgg atggaataat agtcgtgaaa gcagcgatct 2149861 ttggaaacag cccaaatgcc attaggatca cacctgtgac cacaatgacg gcattttttt 2149921 tgatccctgt gagctgaaca agcccgacat tttgagagaa tgccgtgtaa ggaaaagcgt 2149981 taaaaatacc gcccagaagc acagccagtc cttcagctcg atagccttta gacaaatcta 2150041 tctctgtcaa acggcggttt gtcaggtcac ctaaagcaaa gtaaacacca gttgactcca 2150101 caaggctgac aattgcaacg atggacatcg taatgatagg cgctgcgtga aaagacggcg 2150161 ctccgaagta aaatggctga atcatttgaa caactgccgc gtccgaaaca ttatcaaatt 2150221 gaacttttcc cataaaatat gcgatgaagg tgccaatcaa aataccgatc aaaatcgaga 2150281 cggacttgat aaagcctttt gtaaaacggt atagaagcac aatgatactc aacacggtaa 2150341 aagcaagtgc aagattggag agatctccga aatctgcact tccttctccg ccggccatgt 2150401 tattcatggc aaccggcatc agtgtaatac cgataatcgt aacaacagag cctgtcacga 2150461 ccggcggaaa aaacgatacg agctttccaa agaaaaatga aataagaatg acaagaatgc 2150521 ctgaagcgat aatgctgccg taaactgttg aaaccccata ttcagatcca atcgctatca 2150581 tcggcgatac agctgtaaag gtacagccaa gcactaccgg aagcccgatc ccaaaaaatc 2150641 ggttgctcca cacttgcaga agtgtagcca caccgcacat aaaaatatca atcgatacta 2150701 agtaagtcag ctgctcgaca gtcagtccca ttgcttttcc gacaatcaga ggaacgacaa 2150761 tggcgccggc atacatggca agaacatgct gaatccctaa agacagcgtt ttgccgaatc 2150821 catttctcat gaatgaacct cctgtacgaa ggacactttt ccttcttcta aagactgaat 2150881 tcttgccaaa gattccactc ggtagcccag ttttacaagt tcatctcttc ccggctgaaa 2150941 tgacttttca ataacaatgc cgattcccgc aatagaagct cccgcttgct tcacaatcga 2151001 cacaagcccg tgcgctgcct gtccatttgc caaaaaatca tcgataatca gcacatgatc 2151061 ctgatccgac aggtgggtcc cagacactgc gatttggctt tctgtttgct tcgtaaagga 2151121 ataaacagac gctgtcagca agttgtcggt gagtgttaac gatttatgct ttctcgcgaa 2151181 gacaactggc acacccagct tcaagcccgt cattacagcg ggagcgatac ctgatgattc 2151241 gattgtcaca attttggtaa taccgtcttt tgcaaaccta gacgcaaatt catcaccaat 2151301 tctctgcata agcagcggat caatttggtg attcaaaaaa gaatccactt tcaatacctg 2151361 atcagataat acgacgcctt cttcctctat tttccgtttc agtgcttcca tcctgtctac 2151421 ctccgttatg agaataaaaa aagcattgcc cgctcaaata aagagcaagc aatgctgata 2151481 tcacaaaaaa ccgtacacgt gcggttccat tgctcaccca tagtcggaca tttacggtgc 2151541 ccggtagaaa cttgcgtgcc atatccacgc gattatatga gtgttcctat tatattgtaa 2151601 taaattatat caagattcta atctcttgca taggctgaaa ataaaaattc ccgaacttta 2151661 attttgtttt tttagatatc attcgtattt caaggggatt cgatataaaa gagtctgacg 2151721 accgcgccgc caggcttttg attataacag atagagattt gaatatttgt ttgataaata 2151781 atcaattaaa tagcgaacat tcagctcttc tcctgttgca tctttaataa tgtctaacgg 2151841 ctttttccgt tttccgtgaa tgtgcacctt ttccgtcagc cattgcttta tcggatggaa 2151901 ctctcctctt tccaagagag cgtcaaattc agggagatcc tcaagcattt tttgtttcag 2151961 ctgagccgca tacatgtagc cgagcgcata ggatgggaag tagccgaaat ctccacctgc 2152021 ccaatggacg tcctgtaaaa tcccctctgc gtcggtctgc ggtgtaatcc ctaaataatc 2152081 ctggtatttt tgattccaaa gcgacggcag atcttccaca gacacttcat tgctgaaaat 2152141 cgctttttca atttcataac ggatgatgat atgaagagga tacgtcaatt catccgcttc 2152201 gaccctgata aatgaaggtt ttgattcatt gattgcccgg acaaaatcat ccagggagat 2152261 gtccttgaac tgtacaggtg atgcctcttg aatcttctta tagtacggag tccaaaaatg 2152321 cttgttgcgg ccgataaaat tctcgtaaaa taatgattgc gattcatgaa ttcccatcga 2152381 tgcgccgtct gacaagttcg tgccactgag tgcttcatca atattttgct cgtaaatcgc 2152441 gtgcccgcac tcatgaatgg tcccaaagat cgccgtccgg aaatcttttt catcatatct 2152501 cgtcgtgacc cgaacgtctc cccgattcag cgtagttgca aacggatgaa cggtttcatc 2152561 aagtcttccg ccatcaaaat cgtagccaag ctcctgtaaa aaatacagac tgagctcttt 2152621 ttgcttttct ttcgggaacg cttttgtaat aaagcttgta tctggtttat ttccggaagc 2152681 tgtcacctgt ttaacaagag ggataatcgc ttccttcagc tcagcaaaca actgatcaag 2152741 cacctttacc gtgacgccgg gctcaaacaa atcaagcaat gcatcataag gatgctcttg 2152801 atatccccaa tacgtaataa aacgtttatt gaattcaatc agctgttcta aataaggaga 2152861 aaacaagctg aaatcagatt ttcctttcgc ttcctcccac gctgtttctg cctttgaaca 2152921 cagaatcacg tattctttgt attcagcctc agggattttc ttattctctt catactcttt 2152981 tttcgccagt tccactgctt ttttcgtatc ttccgacaag tcatcaaatc gttcatacag 2153041 gacatcgata agctccttca ttcgatctga tgtttggata ttgaatatat ctgttgaaag 2153101 ctggccgata ctttcggcac gatcctctga gccatttttc ggcgcgcctg ttctggagtc 2153161 ccagtgcatt aacgcaactg cttcgctgta atgtgagatt ctttttaaaa gatcaaaaaa 2153221 ttctttttca tatgtatgta tctccatatc cattccctcc ctattctagc cgttccatta 2153281 caggctaatg gaagggggta tgaaagtcaa attgtttgta taaaaggctg ccggtatgtt 2153341 ttgtggcagc ctttttattc agttgatcgt catttgattt tttggcggag gtgttctccg 2153401 ctttttctgc ttgatttttt tatctaccca cactgttgcc agcggggtta agagcgaggt 2153461 gacaataacg cttgtcgcga taattgcagt tgccgactca gcaactggcg caaatgaggc 2153521 attcgcttcc gctaatgcat atggcacggc tacagccgcc cctgccgtag aagaagcggc 2153581 cactcccgcg acaccatctc cccgcgcaat aaaacgatca agcaaaaaca aagaactgcc 2153641 cgataaaatg acgacagaaa ctccgataaa aatgccgagc agccctgatt ggatcagcat 2153701 tccaaaattc aaggtattgc cgagcgaaaa ggcgaaaaat ggaatgatcg ccggcacaac 2153761 cttgctgaat aagtctctga gatcatgatc cagatttcca agtatacatc caagtaaaaa 2153821 cgggatgact gtcgctgcca gcgtttccca tgggaatgcg gcaagtcccg tcacaccaaa 2153881 cgtcaccatg gtcataaaag gaccagattc tgtactgata aaggcgaaag cgcccgcatc 2153941 ctcttttctt cccatgtgat tcatgagcgc caaatacagt ccgccgttcg tttcattcat 2154001 taccgcgaca attgctaaaa cagaaaggcc tgcaaaaaag ccggattgta tgccatcgtc 2154061 aggtataaat tgcgctgcga tcacgccgag cagcgccgca aatccgatct tccccaataa 2154121 taacgtgatt ccttttcttg cgatatagcc tgaagaacga aaatcaatcg ttgctcctac 2154181 gcaaaagata aaaacaccca gtatcggcag cgttccggta atcaaagcac ccgtaaaccc 2154241 tccaaagaac tccgctgttc caggcgcaaa cgtgttgagc gccgctccaa gaaatagcgg 2154301 aataatcatc attccgccag gtacccgttc aattgtcgcc ttgattttca tattgtggat 2154361 tctcccatcc tccggttatg aaaaaacaat tccacttaca cttggaaaac agcctgcaaa 2154421 tcctcttttg aacagctgcc caactggctg ccgactccga cggcgccagc tccggctcta 2154481 agccaatcag gcacttcaga cggatgtatc ccgcctgtcg gaataaaggt cacctgcggg 2154541 aaaggacccg ctaaattttt cataaacgga atgccaaaca caccgcttgg gaacagcttt 2154601 aatgtcgtaa aaccgaatgt cagcgcttcc ataatttcgc tcggagtcaa gacgccgggg 2154661 atataatgtg tctttacaaa agatagatgt tcagcaagat cagctgaaaa acccggactg 2154721 acaataaact gcgcgccagc cttagcagct tccccagctt gctgcgcgct gatgaccgta 2154781 cccgcgccaa ttaaaatatc ttccctatta cggaaggatt cgataatatc tgatgccccg 2154841 ggggtcgtat acgtcacttc aactgcacga atccctttat ctaataaact ctcaatctgc 2154901 tgacaggcct cctgcttatc ctttgaacga atgactgcaa tcagctttgc ttctttcaga 2154961 cggttttcaa cgactttgga ctccatatta ataatcccct ttcttttggt gaaccgttct 2155021 ttgagcagat aaaaaagaag ctaatttctc cctggtcggc aaaccgtcca tatcccccgg 2155081 tgcctgcact tgcaaagcgc caatcgcatt tcccctttgc accgcatcct tgtacgacaa 2155141 accgtctagg ataccgctga ttacaccgac tgcaaatccg tctccggcgc cgaccgtatc 2155201 aaccacccgg tcgacccggc agccttctag aaatccttca cttgtccccg ttttaaagta 2155261 agcgccttct tttccaagtt taatagcaac aaagctggca ccttttttca aataatagtc 2155321 ggcaatgcct tcaggtgttt tttctccggt caatagctct ccctctgcga tacccgggaa 2155381 aaaccagtct gcaagcccag ccagatcatt gattgtgtgt accattgttg cttgatcagg 2155441 ccaaagcgaa ggtcttacat tagggtcgaa tgaaatggtc ttccctgcgt ttctcatgtc 2155501 gttcatgaca tgatacgtga agtctttcat ctcggctgat aaagcaggcg gaatacctgt 2155561 cacatgcaaa tggcctgcgc attgaaaata atctctcgga tattcagctg tagttaatgt 2155621 gcttgcagct gagtttttcc tatagtaggt aacttgcggg tcgccttctt tcacttttga 2155681 cttcagcagc agcccggtgg gattttcgtc ctgcgagcgg atcacgcggg acacatccac 2155741 tccctctttt ttaagctctt gtaaaataaa cgttccgagc tgatcattgc cgaccttgct 2155801 catccatccc attcgaaatc cgagtctggc aaggccgcag gcgacattgc tttctgctcc 2155861 ggcaagccct ttagaaaaag tggatacttc atgaaggcct ccatactcat ttgcataaaa 2155921 catggccatt gattccccga atgtcaccgc atcaagcttc atctcttccc aacctcctct 2155981 tagttgaggg cacctaggat taaagtgact ttctcatgat gacttttgcc tctaattcaa 2156041 tggtttgagg cgctcctttg tcaccttcaa tcctttttaa tacacgttcc atcgccgtcc 2156101 tgcccatatc atgtgacggc tgggcgatcg ttgtaatgcc tggaccgatc agtttgtacc 2156161 actccgtatc atcgaatcct gcaatcccta tatcttgagg gatgcgcagg ccaagctctt 2156221 ccatacagct gatgattttc agcataatca agccattcaa agccagaatc gctttttttt 2156281 gctccggcat ttccttgtga aaagaacgaa gctccgcctt aagctgctcc ttgtccttta 2156341 cgtcaatttc atgcaatctg acaagcccgt tcacattttg aaccgaagcc atttcctgat 2156401 acacagctgc tctttctgca cgagggctga tagaggaaat cggttcggta aacagcgcga 2156461 catcagtata ccctttgctg tacaccttct gaagaatctc ttttgtgatc catctgttgt 2156521 cagtcgttac ggtatccagt ttcagatccg gcagtttccg gtcaattaag attgttggaa 2156581 tttgctgttc agcaaaagcg cggagtacat ccttgttttc ccctgttgcg tttaaaatca 2156641 agccctcaac cgaatgggct tctagcttta agagcatttc ccgctctttt tcaggactgt 2156701 tatctgtgtt gcacaccata atgctgtatc catattgatc acaaacctct tcgactcccc 2156761 tgaaagcagc gaccgaaaaa ggatttgtaa tgtcagccac aacaaatccg attaacttgc 2156821 ttttttttat tttcaaacct tgtgccattt tactcggccg ataattcaat tctgcgattg 2156881 cctttttaat gtttttcact ttttcaggag aaatcgcgtc aatttttccg ttaatatagc 2156941 gggaaactgt cgatttcgaa actcctgcac attcagctac gtctttgatg gttgtatggc 2157001 ctgttgtttt ctttttcatt caagtgctcc tgtatctcat atatttgaaa ccgatttcaa 2157061 aaccgttaca acaaaagaat accataattt taaaatttgg gaagagtttt tttaataata 2157121 tgtcaattca ttattttttc gttgactctt ttcactattt atcctaaaat tttctttgaa 2157181 accgttacca aaatattttc attcaagtga tgctgaaatc ctaaccaagg gggaaatata 2157241 atggaaaatc gttattctgt acatcctgaa caagtaaaac gctttacaac agaggagctt 2157301 cgcagtcatt tcttaatgga ttctttattt acagaaaaca aacttacgat gtattactca 2157361 catgaagacc gggttgtcat cggcggagcg gctccagggc aaagtgaact gaagcttgat 2157421 gcaggtgatt ttctaaaaac agacttcttt ttggaacggc gtgaaatcgg gattattaat 2157481 gtcggccagc ctggtgccgt tagagtcggc gatgatgaat atgtgcttca aacaaaggat 2157541 tttctctata ttggaatggg caatcaggat gtatcgtttt caagcctgaa cggggaaaaa 2157601 gcgaagtttt acttcgtctc cgcttgcgcc cacaaaagct atccgacaca aaaagccgcc 2157661 ctatctgaac tgacaccgga ccgccttggt gatgatgcag cgtctaatgt cagaagtctg 2157721 tacaaagtca ttcatcagga tggcattaaa agctgtcagc tgatgatggg aataacgatg 2157781 ttagatcaaa acaacaactg gaataccatg ccagcacacg ttcatgaccg tcggatggag 2157841 gcttatcttt atctggatct tgaaaaggac tcaaaggtat ttcatttcat gggccagccg 2157901 gacgaaacac gccatcttgt tgttggaaat gagcaggctg tcctttctcc cgcttggtct 2157961 attcattctg gcgcaggaac atcaaactat agctttgtgt gggcgatggc tggagaaaat 2158021 tacacattta cggacatgga tctcattcca atggatgggc tgaaataaga tgggttatct 2158081 acatgacgcc ttttcattaa aaggaaaaac agcgctggtg acaggcccgg gaacagggat 2158141 cggtcaagga atagccaaag ccctagccgg ggctggcgct gatattatcg gcacatcaca 2158201 tacaagcagt ctgtctgaaa cacagcagct tgtggaacag gaaggccgga tatttacatc 2158261 ttttacattg gacatgagca agccggaagc gataaaggat tctgcagctg agctgtttga 2158321 aaacaggcag atcgacatcc ttgtcaataa tgccggcatt attcatcggg aaaaagcgga 2158381 agattttcca gaagagaact ggcagcacgt actgaatgtc aatctaaaca gcctgtttat 2158441 tctgacacag cttgctggca ggcacatgct gaaaagaggt catggaaaga ttattaatat 2158501 tgcctctctc ctgtcttttc aaggcggcat cctcgttccg gcttacaccg cgagcaaaca 2158561 cgctgttgcc ggtttgacaa aatcatttgc aaatgagtgg gcagcgtcag gtattcaggt 2158621 caacgcaatc gccccaggct atatttctac tgcgaataca aagcctattc gggatgacga 2158681 aaagcgaaat gaggacattt taaagagaat tcctgccggc cgctggggcc aagcggatga 2158741 tatcgggggg actgcagtct ttttggcatc acgtgcttca gattatgtaa atggacatat 2158801 tttagcagtt gatggcggct ggctatcccg ctgacaaata aaaaagctga cgaacgatcg 2158861 tcagcttttt tccattacat catgtgcggt tcaacaggca agaccttttt gacctcatca 2158921 atgatgcgtt cattttctcc gccagcgtaa atgtgaatcg agccgctgtc ttgattcgag 2158981 cgaatcaggc gcccgatgcc ctgccgtaca cgtaacaaca tatatggcag atcaacttct 2159041 tcgaacggat cttttttcgc tccgttgcgc ttcgctgtaa atacaggatc gtgtggcggg 2159101 aacggtaatg accaaatggt aacattcttc aatgcgtcac cgggaatgtc gagtccttcc 2159161 cataagtgaa ctgaacaaag tactgtttct tcttcctctt ggaatttctc tactaagctg 2159221 ctgatttcct catcaccttc gaagaaaatt ggatacggca gctcccatgc cgccgacagc 2159281 tctttaaact cgtttaattc ttcaaaagaa gggaaaagca ccagcgttct tcctttgtat 2159341 cgtttgattg tttcaatcgt ttcagccgtt ttttgttcag cgtccatatc tgtttttgcg 2159401 tatagattaa tactcatttg ctcgtcataa tcataagggg aatcaacagt taatgacaaa 2159461 taatcatgaa tcccaagact gtcggcaata taatcaaacg aaccgccttc tgacagcgta 2159521 gcagaagaaa agatataagg aattttctta gaaaacactt tttcgccaag tacttctgct 2159581 accgttctcg gcatcacgac aaaggttgat tctgcttcct ttttctccag ccagctgatc 2159641 gcatcctttt gatatagaga taatgaatac gccatttgtt caacatattc ttccactact 2159701 gacagttcgt attgatcaat cgtatacatt tcagactcaa atacaagtgc ctcaccgatt 2159761 ttatcaagta aacggcaaag ctcgtccgcc gcctttttga cacgatggtc attttttatt 2159821 tctaaacggt gtgaaccggc tacttccttt gattcttcag aaagaacata gaaaaattcg 2159881 tcgtttgcga gaagcgcatc ttcaatcaat tctgcaaact cttctctgat gtcattttgc 2159941 agcaatcgtt ctaaaaacaa ttcaagagta gactgcttca ctctataggt tagcgctttt 2160001 tgcgcagcaa actctaacaa gtgcccctca tcaaatacaa ctgcactatg atcaggcaag 2160061 agcggcagct ggccctctcg tttgcgtgat tcttccgtcc acacatgctc catataaaaa 2160121 tcatgggaac aaatgattaa gtccgttgac ttgcggtagt aatctctgga aagtgtcaga 2160181 ccgcatctgt gtctcatatc acaagtcaga cagtcctgaa acgagtcgta gcttacgtca 2160241 gaccactctt cattcgatag atttgcgtac tgcttacggt cgccatacgg ataaaagcgc 2160301 tgcatcgcct gggactcgtg gacaaatgac ggtaacgact cataaagatc cagccattta 2160361 tcatcatcag aacgctgcat tgttttttca agcttcttca agcataaata ttgctcatgt 2160421 gattttgaca gccttgtatc aattttcaga tcaagatgct cagccagctt agaaatatcg 2160481 ccctcttttt tcaccagctg ttcaattaat gtttcatccg cacaagcgat gatggcaggt 2160541 ttgccgacat accttgcata gctgattgca aaaagaagat ataccagcgt tttccccgtt 2160601 cccactccag cttcggcgaa catgactttt ttctctttaa acgcccgctc cagctgaaaa 2160661 gccataaata cttgctcgtc ccgaagatca aacccttttt cgggaaggat atcgtaaaac 2160721 acgtcaccaa tccaattgtt caattcttca taaaaattct ttgttttcgt taaagaaaaa 2160781 ggcaaacgtg atgttgtcac ctagttccaa cccccaacta ttcgacattc agaccaccaa 2160841 taatatcatt ttccgctgat gaatacaata aaaaacttgg caatgccaag ttttttgcag 2160901 tttacttacg attgatcaca tgcgacgata aaaaaggatg gtctgttgaa taaatatgtt 2160961 ctaccgcttt ttctaaatca gtttgcgcat gcgaaatcac agacggagac gaatcagtcc 2161021 cgagctcctt cagctcgttt gctgttgcgt caagcgccct ttgaataaga ttaaaatgtt 2161081 cgctgttcag catgagatca cctctgatgg aaataatcat cattgtatgc gaacttttca 2161141 ttttatatac atgctttacc gcatgttatc accgaaacat gcacaaacta cacttgatat 2161201 tccgtctccg gattatccgt cttatcaaca atattctatc agggagtgat gttgacatga 2161261 gttatagaaa ccgattagat cagcattctg aactgtttca tcacaattgg acgcggccta 2161321 aacgttcaaa gtctcaagta aacggtcaca ctgaaatgtc ccaaaccaac attatattga 2161381 gaagcaacgc gaaagctcac cgttggtaac gatagaatag ggctgaaaga tgaaagaaga 2161441 cgcatgcaga gcgtcttctt tttatgcgtt ttctgttttc ttgcgctgcg gtcttacttt 2161501 tgaccagtat tgataataat ccgttttaat aaacccgtta aagagttttc gtttcttcgt 2161561 tgcttttctg ccatatgctt cctcaaagtt ttcatttgat gtcagcatat acacagacca 2161621 agtatcaagc ggctcgaacg cctgccccat ttctttgtac atctgctcaa cggctttttt 2161681 ctcgccgaga cgctctccat atggcgggtt gccgacaatt acgccaaatt ccagatttgt 2161741 ggtaaagtct ttgacctgca tctgtttgaa ctggattaga tctcccaatc ctgcttcctc 2161801 tgcattttct tttgcgattt gaaccatgcg gtggtctatg tcgctagcga aaattgtaag 2161861 cggctgatca taatttgcct tttcttcgac ttcaagccgc gctttgttcc acagatcttt 2161921 accgatccat tcccaatcct ctgatacaaa atcgcggttg aatcccgggg cgatgttttg 2161981 gccgattagc gccgcttcta tcgcgattgt tccggagccg cagaaaggat caacaaacgg 2162041 gcggtcaggc gtccaattgg ttaattgcac caaagcggca gcaagtgttt ctttaatcgg 2162101 cgcaccgccc tgatcgacac ggtatcctcg tttgtgaagg cccgtccctg atgagtccag 2162161 tgtaatcaaa gcctgatctt tcaataaaga tatttccact ttatactcag cacctgtttc 2162221 ttcaatccaa tcattggctt tgccggactg cagcttgagc ttttcgacaa ttgctttttt 2162281 gacgatccgc tgacagtcag gaacgcttgc aagtgttgat tttaccgatt ttccgatgac 2162341 agggaatttc ccgttttcag gtataaatga gcgccagtta atcgctttcg ttttttcaaa 2162401 cagttcatca aatgttttcg ctttaaaaga agcaacctga acctttatgc ggtcggctgt 2162461 tctaagccaa aggttcgcac ggcagatggc aagtgcatca ccttcaaaaa taactttccc 2162521 gttatcaacc ttgcattcgt atcctaaatc tcgtacttcc tttgcgacaa cagcttcaat 2162581 gcccatcggc gccgttgcaa ttagtgtata cttcttcatc gtatcaccct gtcttttaaa 2162641 acttttctct tttcaagata aaagctctcc ttatacggga gagcttgttt tcatcatttt 2162701 aaatgtaagt ggtctaacgt tctgtaagcc atgttttgtt ccatcgtact gcaaacggct 2162761 catcacctcg tactcaggcg gcaatcatct atctacagaa agcattctgt ccttctctcc 2162821 gttgaattcc gttaagaagg ttcccctacc aaaatttggg tttctcgctc gaggggttta 2162881 ccgcgttcca ctctcaccat ttctagtgag acttcgtcac tgtggcactt tcaaggatac 2162941 tcagccatat ccgaagacgt aggctttttt cctgccgtca gcctctaaag actgccctag 2163001 cttatgactt cgctaggcac gaacactacg ggcatctcag caccgtgcga gcatggactt 2163061 tcctctacag attcaagatc tgcagcgatt acccgaacgt taagaacatg aattattata 2163121 taacaactga ttacaattta caagcgccat ttttttcaag cgtgatcaat cataaagctt 2163181 gctgccaaaa acgtgttttt ctaagttaga cagccgtttt aaaatatcaa agtttgttgt 2163241 gttagattgc acaggctgtt ttttgctggc ttcttcaagc tgttttttca gctgcagatt 2163301 ttcctgctgc agttcttcaa tttcttgatg gaaggtttca taatccttaa taatcatatc 2163361 taaaaatttg tcaacgtctt cttgcttgta gcctctaacg cctgttttaa attctttttc 2163421 caaaatttct ttcgcagaaa gctttacttt atcagcaagc atctttttca cctcgtatcg 2163481 tgaatcatca catatatttt ttcagaaatc tgtacggttg tcaaatttct ctctcattgt 2163541 tagtagctgt cttcctccac tgtcactctc aagtcatcca ttgtaataaa gtagatggga 2163601 tagccatcct gttcgcgcct tttttccgct gtcccaagca tatacttagg ggagccttcc 2163661 ttttccgggt catataaaag cagaagcccg tcggacttat caatgaagaa ctgatttttt 2163721 tgtttgaatt gaagcgggct ttcataagga cggtgagtca ggcttgcttc atagtctgcc 2163781 tgagccagaa ctgcttcata ctgttcttta ttcggttctt tccagttctt ttcctgctcg 2163841 taaaatggtg tgatgacagc tacctttaag tcagggtatt cctcctgcaa atcatatgca 2163901 gcttctgccg cccacagctc aactccaagc tggcccgaaa ttaaaatcca ttctaatcct 2163961 tcatccaaaa aagcaatcag ccggttttta atggcttttt ttatgtaata cagcgccttg 2164021 tcatcctgct taaatatccc cagttcaaac ggtttatagc ccgttattgc caatactttc 2164081 atcatttcac ctgctttaaa aaatggggct cccgtgggcc ccatttgttg tgctgcattg 2164141 tttacaccat caagctgcac gttttccata ctagtagtcg cagcaaggtt ttcctgcttg 2164201 aaaatgctga tgcgtagccg ggtcaacatt tgagaaagtg tgtggaaagt agtgaacgtg 2164261 ctgaaaatgc tggtggttta cgtttgttgt atgctgtggg tgaatgtgcg gcacgatagt 2164321 cttcgaaaac gtatggtgtt cacagcaatg agtaggatgg acaattggcg ccatcatatg 2164381 cggtctgcag tgatgcatga taaaatcccc tttccataaa ctttattaca atactaagtt 2164441 atgaaaaata aggggtacat gttctgatgc aaagacctat tttaaaagtg tgcaattaag 2164501 ctgtctttaa agtttgaaaa cacaaaagca atcaaaaata ccacaacaaa gaacaagtaa 2164561 aaaacaccct tatacatacc aactctccct ttaaaaataa ctaacgtcat tttacaggat 2164621 tcgccgctat tctacaacaa aatcaatgtg aattcagcaa aaaaaattca tggcgaaaca 2164681 agtcgtcttt tgcgctttcc cggggaatat ttaagaggaa tatttcctct ttagccgggc 2164741 aattctcaca tgcagttttt cagtttcttt ctctgataag catgccgcat cgctaagcga 2164801 ttgctctgct acttgcaatg cttttccgaa ttcttttttc ttatgctcaa aatatttcgc 2164861 gagctctatt acagcagcgt atctgcactt ctggttttgc gagcgggaca gcttttccca 2164921 aagcggcact gcttcttcca agcggttttg ttttttgtac aggagcgata aatccagccg 2164981 tgcactgtcc tggtcctcaa acgatttttc tataagcctt tccaactgct tgatcgcttg 2165041 gtccgtttct ttatgagcca taaaccattt cgccatagca taggcttcac tgtgttcttt 2165101 tggcgcatgt gattctgaaa ggattttttt agacatatgg atgtacaatg aaatgagtga 2165161 taacacatcc atttcattat gatgcaggac accttttaaa agatccggct cttgcgcctt 2165221 gataaaatga aagtaaagca ttggcgccaa gtagcccggt gtgtcttcta gcctgcggat 2165281 gccgagctcc tctttttcaa ccgtgccaag agatacacgg tccattttgt gtttccacag 2165341 gcgtctagct ccatgcaaaa gatcaaagtg gccaaactcc ggaagcttcg gaagtctgtc 2165401 acggatcaag gtgtgccttg ttttcacctg cggccaatca aaggctttgc cgttgtaggt 2165461 cacaagtgat gtaatgtcaa cctcgcttaa aaagctttgg tacaaggcga cttcgttccc 2165521 cggtttgggc aaaagatgct gtttgactgt cactcggtct tcatatactc tcgcatgccc 2165581 aagcaaaaaa atggtattcc cagctccacc cccaagaccg gttgtttctg tatcaaagaa 2165641 aaagaggttg tttttgttat acccttttgc tgacaatgta tgcgacaggc cgctttgatt 2165701 ccacagtgtg atcacttcct caagctcaga aaagctgtat aacccatggc ggtgagaaag 2165761 cggatattct acttctctga tgaggcaata ttcatcttcg aagatgaaag gcttcatgcc 2165821 aaaagcctcc cactcttcta aaaacgggat gtcatcaaag tggttttctt gtttgcctgc 2165881 ttctattttt tgttctcctt cgtcgagcgc catgtgcttt ttcatccgtt ggagtttccc 2165941 ttttaatgac atatccggcc tccctcctta cgacatttga tccaacagct gcaaaattct 2166001 ttcctttgct tttatccctt ctatttccgt acctatacaa gacggacagc cgtcatgaca 2166061 aggacaatgt gtaatcagtt gtttcgccgc ttcattaatg tctgaaaaac gtttaaagac 2166121 ttcctccgcc aaaccgatac cgcccggata atgatcatat aaaaatatgg ttggcaatcc 2166181 ggtatgggct gctttaattt gagaaacaac atgaacatca tttcgatcac acatgatata 2166241 cacagggaca atatgctgca gcacattcga gatgccaaga agcagctgtt ccagtgtctt 2166301 ttccccgatg tcttcatccg ctgttttgat ttcgagccaa gctgcacttg tatgcagttc 2166361 ttcttccggc aaatgaatag gtccagaccc aatattttca aaagtggtca tttttatttt 2166421 tttaaaaatg gtcggcaggg cattgacagt gacgtctccg tagtgcaatg acgtacggct 2166481 tttttctttc gttttatcga tttctaatac cttcagctga actgccaggt ttgcatccgt 2166541 ataatattcg acatcgactt ttctgacata cgccttttta tggtcccaat cgagcttctc 2166601 aacttgatac tgaacgcctt catgcaaata aatcgcttca tcatgcaaaa gcgtcatcgc 2166661 actaaaacgg tccatttcac cgataatcct tacatttgca atatccgact gatcaactat 2166721 aacgacattt tcctgggagg cggaacgcaa actgatgttt gacgcaggga acgactcact 2166781 tgcccaatgg taccgttcgc cgttgcggtg aagaacagcc tcttcctgaa gatactcaag 2166841 aatatcactg acttccatgg ctccaaattc ttcatcagct ctaaaaggaa gctcataagc 2166901 cgcacacttt aagtggtcta ctaaaataat caaattctcc ggattgattc ttgcagattc 2166961 cggcgaacga ttaaagaaat attcaggatg ccgcacaata tattggtcaa tcggtgttga 2167021 attggctacc atgataatca aagattcacc gtgtcttctg ccggctcgtc ccgcctgctg 2167081 ccaagcactt gcaacacttc cgggataccc cgtcattaca cacacttgca gctggccgat 2167141 atcaacacca agctctaagg cattcgtact gaccactcct aaaatgtcgc cttctctcag 2167201 tcctctttcg atttctcttc gctctttcgg cagatagcct ccccgatagc ctctgattga 2167261 ttttgttcca atctcttttt tcacaagctc ctgaatatgg cttaaaataa tttccacccg 2167321 aactctgctt ctggcaaaaa caatggtctg cactttgttt ttaaggaact ctttcgccag 2167381 ttcattcact tctgcggttg cgctccttct aatattcagc ggtttgttca caattggcgg 2167441 attgtaaaac acaaaatgct tgcgtccgct cggtgcgccg ttgtcatcga ccagccgcat 2167501 cggtttgcct gtcagctgct ctcccaattc ctttgggttg gcaatcgttg cggaagtaca 2167561 aataaaaact ggatcacttc cataaaaccg gcagatccgc ttcagccgcc ggatcacatt 2167621 tgccacatgg ctgccgaaca cacctcgata cgtatgaagc tcatcgatga cgatatactt 2167681 aaggttttca aacaaactga cccatttcgt atgatgcggt agaatggcag aatgcagcat 2167741 atcggggttt gtaatgacaa tatgacctgc ttttctcacc ttttgtctga ttgccggaga 2167801 cgtatccccg tcatatgtaa agcttttaat atcaatgccc atttcatcaa taatttcatt 2167861 tagctcgctc ttttggtctt gtgccagcgc tttagtcgga aataaatata acgcccggtt 2167921 tgtttcatct tgggcgatgg actgcaggac tgggaggttg tagcataacg tttttcctga 2167981 tgctgttggc gttacggtaa cgatgctctc tcctttttgc acatattgaa aagcggaata 2168041 ttggtgagta tatagttcat caatgcccct tttcgaaagg gccgctttga ttctctcgtc 2168101 tatactttcg ggcataggcc ttgtttttgc ttcccgaggc tcaatttcat gccaattcac 2168161 aacgttttca tttcctttta aatcagaaat gagttcagtc agtgatttct ttttcattct 2168221 ttacacctct ttgtcaagta cagtttaccg aatatttgtt tgcatggcta ggtgcaaatt 2168281 ttatacagtt gaataaaaaa agcaaggcat acgccctgct tatttcgctt ttattgtaaa 2168341 gagctttgat tcgcctttac gagcagcctt ttcgcctgcc gataccattg atcctacagc 2168401 ctcaccattc attataacga ttgggatgac tgtgctgctc gctttttctt ttattaattc 2168461 caaatcacat gtaatcagcg ggtcaccgac cttcacttta tccccttctt taatgtgggc 2168521 agtaaatcct tctccgttca tattgactgt ctccagcccg acatgaatta acagctcaat 2168581 tcccgagcga gtccgaatgc caacggcgtg tttggtgtgg aaaatctgaa tgacttcacc 2168641 ttcagcggga gaaacgattt caccgctaga aggttccacc gctattcctt ctcccatcat 2168701 tttctgtgaa aaaacagggt ccggtacatc tgacaggtcc attactgtac cgtctgccgg 2168761 agaataaata acctcttctg tcaccttttc ctgaattttg cccattccga ataatttttt 2168821 cagcaatgta ttttctccct tctcattcac ttcaaccgtt atcccttcat tcaccactat 2168881 ttaaccacac tttcaatttt gcttcaattt ataacaacat ctggcataga cgcataatct 2168941 ggttaaaaaa ggcggtggcg atattggaat tccatgatga caaaaagaac gaactgcaaa 2169001 agaaagaaga aatcataacg gaggcaatcg acactctttt tcaatcctca gcgttcggca 2169061 accttataaa cggatttcag aacctaatca actcgagttt aaaggatgtg cagacgacca 2169121 tacatgtcag agaaagagat actgggctgt atatcgatat taccattccg gcgacgtttc 2169181 gagatggcga gatcgtcgtt gatgttaaat cgaggtatct ccatgtaaca ctccaagaaa 2169241 aacagaaaca ccaaaatgag gctaccttta caagcatgac aagaacggtt cagctgcctt 2169301 atgaagttcg ccaagaagat atggaaacgt cttggaacga gcagacaatg acacttttct 2169361 ttccaaaaaa taagcatgaa tgaacgattc attcatgctt ctatcattta aaaaagctgg 2169421 taaatccctt tattaaagat ccgacctgat tcattgcact cattacttga cctgtcgtat 2169481 ccatcatttt attaaaatca aattgcccat tggctttttt gaactgcgac ataatgcttt 2169541 gaaattgtga aggctgctgt tgattaggcc ttgggatagg ataagggtta gaaaatacag 2169601 gcggctgcat aggcataggc tggatcggag cataaggctg ataataatcc tgctgtccat 2169661 aatgctgctg aggcagttgt tgctctaaat aaccgggtgc agcctgctga taatatcctt 2169721 gcatatgctg aggataataa tagcccattt gccgaggata gcttcgagag ctcccgttca 2169781 ttgcgattcc cccctaaaca caacatattt ctcttctata tatgtatgaa tgacttctat 2169841 tgtttgtgtc acaagtgatg attagcattt gtcaaattgt gtcgaaagtt taaatttttt 2169901 aaaaacagaa aaaagtcgaa tcattatggt accatatttt caatacagat gagaggggat 2169961 gcaccataat gaacgtatca tacttaagca aacgttttgc agaaatgaag aaatatgaaa 2170021 cagactgtat gaataaactg atggactttg ccaagttcct ctatattcaa ggacatctca 2170081 gcataactga gtttcgtaac agtatgaagg ttctcgaagc aaatggagca gaaagcccgg 2170141 catatgagat gaattaacgt ccggccccct ataaaaacga aaagaagaca gccttttacc 2170201 ggctgtcttc tcttgcaatt tcatccttta ctgcgtgcaa tgtataaagg actgactcag 2170261 tgatgtcctt gaatcgtttt ttatgaatat gatgaacata agattgaagg accaattcca 2170321 ggaaattatc ctttacggcc tcaatttgct ctttatgcac atattttggc cggcggactt 2170381 ttatcaattc aagagcaccc tctgcccagc gagcagccag ttcatcattc tcttcaactg 2170441 caggctttat cgtctcaaaa aaatcataag aatgattact gttttttcct tcctgatacc 2170501 gatcagcgcc tttttcagca acttcaatca tttgctcggt catttccagc aaagtttgtg 2170561 atagcaatat ctttcacctc aatgcctatc gtaccaaatt tcactcacaa attcagccga 2170621 tgcggtatac cttctcaaac gcatacctgt gttcaggcga ttgatacagc tcatttatac 2170681 aaatatgaag atctatgatt tcttcttcga gcacacttag gcgatcgttc tccgtttccc 2170741 gcatctcagc ctctaatgca tttacagaat gattcaggct ttgctcagct cgcgttaatt 2170801 catcttctat atcagaaagc atacggagaa tatctgtctt gcatacataa ccggacattc 2170861 gtgtacctcc ctttccttgt ctctcccggt taacattctt tgctctcaag gctctttcct 2170921 tcctcatgac aaaactagaa gcaaatcgcc aaacaaacag gtattccacg aaaagctgaa 2170981 gttttcgaca aaaacacccg caaaaattgt atgatcctcc tcattaatgc aaacgatact 2171041 tgtgaggagg tgccgtatga aaacaagacc gaaaaaagcc ggccagcaaa aaaagactga 2171101 atcaaaggca atcgattctt tagataaaaa attaggcggc ccgaaccgcc cttctacgta 2171161 agaagcaagg aatttccttg cttctttatt ttttcagcca ctgctccacc gcaaaaagcg 2171221 catgaagctg gcgcttttta tgtaaatacc agtctgtcaa ttcaatctgc ttcggcaatt 2171281 cctcgcgcct aaagaacgtt ttctttatct ttccatgaaa ccaatctgtt ttcgttccgt 2171341 ctaatgagtg gattaactca gggtagcatg tccttagcat aggagatgtt ctttttgtaa 2171401 tcccgatcat cttttccata tcaaaacggg aacctgtgtg cggcactgtg tgcaaaaagt 2171461 gataaaaaga ggagaacaat tctggcttga acagcaattg agacagctgc tttcccagcc 2171521 ttatcctttc ctccgccttt gaaaagcgtt tcactgaaat gccgtaaaaa aacccatttg 2171581 aggaaggaaa aataacggtg ttaaaatgaa accagtcact taaataaaaa ggaatcgtgt 2171641 caaaaacatt ctttttaaac gaaggatttt gtataatagg tgtttggata gtgttttgtt 2171701 catttataat gagggcatac attagccgct ccgtatttcg ctcatgccaa aaacgggtcc 2171761 attcttccga cataaattgt gagacgccaa acacatgcag cagatgaaac agcggtttcc 2171821 caactctttt tgaccagtgg tataaaagaa gctgcggata ggcatccgaa aaaataagcc 2171881 agttcgctct ttcataggct aaaaagaacc atttttgctg tctctcacgg agtccaagct 2171941 gaaacagact gccttttaag tcagtcattg accagccggc attacgagaa acgaaagaag 2172001 ccaaaagcga ccatttgatt tccggatgac ggtcgtaaaa tgctttataa gcatttgttc 2172061 ttgaaatgtt atccgcgttt ttcatttttg tctgccgctc aatccggctc agaagctttc 2172121 tgatggcctg ttgttcttgc acgttcattc acttccgtca tgattagttt aataaggagg 2172181 atgagaaagt gattcggtat cctaatggaa aaacatttca gccgaaacat tcggtttcat 2172241 cccaaaacag tcagaaaagg gccccgtctt acagtaatcg cggaatgacc ctcgaagatg 2172301 acttaaacga aacgaataag tattatctga caaaccaaat tgccgttata cacaaaaagc 2172361 cgacacctgt tcaaattgta aatgtccatt atccaaaaag aagtgccgca gtgattaaag 2172421 aagcttactt taaacaatca tcgacaacag actacaatgg gatttacaaa gggcggtata 2172481 ttgattttga ggcgaaagaa acgaaaaaca agacctcttt ccccctgcag aattttcatg 2172541 accatcaaat cgagcatatg aagcaggtaa aggctcaaga cggtatttgt tttgttatta 2172601 tatccgcttt cgaccaggtt tattttttgg aagccgataa gctgttttat ttctgggaca 2172661 gaaaagaaaa aaacggcaga aaatcaattc gaaaagatga gttggaagaa acagcttatc 2172721 cgatttctct tggatacgca cccagaattg attatattag tattattgaa cagctttatt 2172781 tttcgccatc atctggtgcg aaaggttgat taacgaaagg ttgagatgtt atgtcagatc 2172841 aatttaacag ccgtgaagct cgacgaaaag cgaacagcaa atcgagtcct tcaccgaaaa 2172901 aaggcaagaa acgaaaaaag ggcggattgt ttaaaaagac ccttttcact ttactcattc 2172961 tgtttgtttt aggcgtagtc ggcggtgctg ttacatttgc cgtcatggtt tctgatgcgc 2173021 cgtcccttga tgaaagcaaa ttgaagacgc cttattcatc aacgatttat gataaaaatg 2173081 gaaaagagat cgccgaagtc ggcgccgaaa aacggaccta cgtctcgata gatgaaattc 2173141 ccgatgttgt aaaagaagcc tttatcgcga cagaagacgc tcgtttttat gagcaccacg 2173201 ggattgaccc tgtccgtatc ggcggtgcat tagttgccaa ctttaaagac ggcttcgggg 2173261 ctgaaggcgg aagtacgatc acccagcagg tcgtcaaaaa ctcccttctt tcacatcaga 2173321 agacgttgaa acggaaggtg caggaagtat ggctttcgat tcagctggag cgcaattact 2173381 ctaaagatga aattttagaa atgtatttaa accggattta tttttctcct agagcatacg 2173441 gaatcggaaa agcggcggaa gaatttttcg gcgttactga tttaagcaaa ttgactgtcg 2173501 aacaggctgc gacgcttgca ggaatgccgc agagcccaac agcgtacaac ccggtcaaaa 2173561 acccggataa agcggaaaaa cgacggaaca tcgtactcag tctgatgaaa aagcaaggat 2173621 ttatttctga ttctcaatat aacaaagcga aaaaagtggc agtgaaagac gaaggcgtcg 2173681 tgtcacagaa ggaatatgaa aaagcaagta caaacaaata cagcgcattt gttgaagagg 2173741 ttatgaagga aattgatgaa aaatctgatg tcgatccatc tgctgacgga ttaaagatct 2173801 atacgacatt agatacaaaa gcacaagata aactagatga attaatggac ggagacaccg 2173861 tcggatttac tgaaggcatg cagggcggtg tgacgcttct cgataccaaa aacggagaag 2173921 tccgagcgat tggtgcggga cgcaatcagc ctgtcggagg ctttaactat gctactcaaa 2173981 ctaaggcaca gcctggttcg accataaaac cgattttgga ctacggacca gttattgaaa 2174041 ataagaaatg gtccacatac gaacaaattg atgactcagc ttatacgtat tctaacggaa 2174101 aaccgattcg tgattgggac cgcaaatatc tagggcctat ctcaatgcgt tacgctctgg 2174161 cccaatcaag aaatatacct gctttaaaag cattccaggc agtcggtaaa gatactgctg 2174221 tagactttgc aaatggactc gggcttggtt taacaaaaga taatgtaaca gaggcctatt 2174281 ctattggcgg tttcggtggg aacgatggtg tttctcctct gacaatggca ggtgcataca 2174341 gcgcgtttgg aaataacgga acgtataatg aaccgcattt tgtaaaatct atcgaattta 2174401 acgatggcac gaagcttgac ttaacaccaa aatcaaaatc agccatgagt gattatactg 2174461 cgtttatgat tacagatatg ctgaaaacag ctgtgaagac aggtactgga cagcttgcac 2174521 aagtacctgg tgtagaagtt gcaggaaaaa caggaacgac taactttgat gataatgaag 2174581 tcaaaaggta caatatcgct agcggtggcg cccgagattc ttggttcgtt ggctacacac 2174641 cgcaatatac agctgccgtc tggacgggaa tgggagaaaa cgaggctgga aagaaatcac 2174701 tttcagctga agagcaaaaa gttgcaaagc gcatcttcgc ccagctcatc gccgatgtcg 2174761 atgacggaag cggatcattt gagaagcctg acagcgtagt ggaagccacc gtagaaaaag 2174821 gttctaatcc ggcaaaactg gcagggccaa atacgccaag cgataagaag ctcacagagt 2174881 actttgttaa aggcacagct ccttctactg tttctaaaac atatgagaaa gaagaaaaag 2174941 aggaaacagc taaactgtct ggtttaaacg tgaaatacga taaagacaat caatctttaa 2175001 cgttaagctg gaattacgac ggagatgcga cctttgctgt taagcaatct gttgacggcg 2175061 gcagctactc ggaaattcaa aacagctctg caaaagaggc agttatttcg ggtgtgcagc 2175121 caggatctgt atacaaattc gaagtaacag ccgtcagtga tgatggcaaa agtacagctt 2175181 ccacatctta tgaggtgcca aaagctgaag acgatgaaga taaaaaagac cagcaacaaa 2175241 cggatgatga aaaacaagat gatgagaaga ctcaggatga tacacaaact gatgattctc 2175301 aaaaagatga cggtcagacg gatcaagatc agacagatga ttcaacaaac gatcaagaca 2175361 aaaaacaaga caatacgaac accaatccgt ccgacaacaa taaccaagac caatcaaacg 2175421 ataatgataa cgacaacagt aacaaccagg atacgtcgga tggtgattcg aactctggta 2175481 agaatgattc aacaggttct gacacgaata aaaataaaac agacacatct aataaaacac 2175541 aaacaaactc atcatccatt gaaaaaacaa attaaacaaa aaagccgtca cctttggggt 2175601 gatggctttt ttggtacaca ataaaaaacc tcccgtttta acaggaggtt ttatcgattc 2175661 atcgcatgat atttataaaa atgctttttc atttcggtaa tcagctcatc aagctgaata 2175721 aagcaatggt attgggtcgg cttaagaaga ataaattcca ctcgttcagc ccaattaatc 2175781 ggctttgcgg gatatgattt ctccctcagt tcttgccaat cgagcgattt caccggctca 2175841 cctgctgtcc aatgtaacga agccagcaaa cacacaatgc cctttaacat ttcgttttgg 2175901 tcacatctcg attttcgtgt ttgaaagact gggagaagtg atgctttgat gtcatcccac 2175961 acttcaaata aaagcggaac gtatttcccg ctgtcctccc atggcaaatc gccttgtaat 2176021 tccgtgcaga aatcaaaata cacgggattg gtctgcaagg ttttcttcat atccgaggaa 2176081 ctcttctggc caagactgcg caagtattgc tcataggaag ccaacacttc ttttgcttgc 2176141 gtcatcgttt caccagtcct tttttatccc tcttctgccc ttctctgcac aaagaaagca 2176201 gcggacactc cgcacagcgc ggagattggg ctttacagtg atatctgccg aagaaaataa 2176261 gccggtgatg cgtaacggac caatcttctt tgggaacctt gcgcatcagc gtcttttcaa 2176321 cttccagaac cgagtccttc caccggcaaa tgcccaatcg tttgctgact ctctccacat 2176381 gggtatctac ggctatggcc ggcacgccaa acgcaacgga taccactacg tttgcggtct 2176441 ttctcccgac ccctggcagt ttgacaagct catcgcggtc tctcggcact tctccgccgt 2176501 aatcttcaat aatcatttta ctcagctttt gaatattttt cgctttatta cgatataaac 2176561 cgattgattt aatatcctgc tgaagctctt ccagcggaac agccaaatag tcttccggcc 2176621 gtttatattt ttggaataat gttttggtca ctctgtttac aagtgcatct gtacattgcg 2176681 cagataaagc aacagccacc actaattcaa aaggattgga atgaaccagt tcacactccg 2176741 catgaggaaa catgtcacct atcttgtcta aacagaattc aatttgtttt agatttaaca 2176801 cgattgtcac cttttcactt tattgttcaa gccaattgta aaaaggaacc tgccttttat 2176861 actctttttg cggttcattc tgctttgctt gtacacgccg gaatttttgg ctgtgtattt 2176921 ttgcctgctc cacagtttta agcccatttt tcttccattc aaacaaaatc cggtcaatgt 2176981 agcggaaact gagttttcct gatagtacag cctcttttaa cgcgtgtttg atcagttgtg 2177041 cgtcatgctg atcctggtcc tgccagatcg ccagcgtttc acactccaaa ggcgataacg 2177101 gtcttgcgaa ctcttcctca aaaatggtat aaaggctttt ttgttcccct tctgcttttc 2177161 tttcctgtgt ttgattctgt gcaagctgaa tatactcgta cagcttgccc cataaaggct 2177221 gaagagaata tttctcaaat ttgatgccgt tttgatcctc gcattcttca ataaacagaa 2177281 agcctttttg aataaacatc cgcaatctgt ttgtacattc ttcaacagaa attgacatac 2177341 cttcctgcag ctgattcggt gtaggaaaat atgatccttt ttctaaatgc attttaattt 2177401 ttaacagcag aataagttct gtttcattaa gcccaagctg tttataatgc gtgagcagaa 2177461 gattggggat ggttgatgtt ccctgctcct gcatatcaat aaattgctgt tttttcatcg 2177521 tcacacctct tactgtaaag gattgtgatt gcccctttac tgtaaaaagt ctcccttgca 2177581 ggagactctt ttttgtttca tttgaatgta ttacggatac agacggttta acagtcttgg 2177641 gaacggaatc gtttcacgaa cgtgaggcgc tccgctgatc caagctactg tccgctctaa 2177701 tccaaggccg aagccggaat gaggaactga tccatatttt ctaagttcag cataccattt 2177761 ataagcgtca gaatccagtc catgttcttt aagacgcgat tccaaaagtt ccatatcgtg 2177821 aatccgttca gacccgccga tgatttctcc atagccttcc ggcgcaatca agtcagcgca 2177881 aagcacaacg tcctcacggt cagaagccgg ctgcatatag aacggtttta aggacgtcgg 2177941 atagcgagtg atgaataccg gtttgtcata atgttcagca atcgctgttt catgaggcgc 2178001 tccgaaatca tctccccact cgatatcgtc aaagcctttt tctttcagaa attcaatcgc 2178061 ttcatcatac gtaattcttg ggaacggggc tttgatttgc tcaagttttg acgtgtctct 2178121 tcccaatgtg tttagttcaa ttttgcaatt tttaagaact gattgcacga tgaaagaaac 2178181 gtaattttcc tgtacttgaa ggttttcttc aaattctaca aacgccattt ccggttcgat 2178241 catccagaat tcgattaagt gacgctttgt tttagacttt tccgctctga atgtcggtcc 2178301 gaaagagaat acttttccta aagccattgc cgcagcttcc atgtagagct gtccgctttg 2178361 agacagatat gcatcttcat caaagtactt tgtcgcaaag agttctgttg ttccttcagg 2178421 tgcgcttcca gtcaaaatcg gcggatccac ttttacgaag ccttcgttat taaagaattc 2178481 gtaagtcgcg cgaatgattt cattacggat tttcatgatc gcatgctggc gctttgaacg 2178541 cagccataaa tgtctgtgat ccatcaaaaa ttccgttccg tgttcttttg gtgtaattgg 2178601 ataatcggtc gcttcgtgaa tgacttcaat atctgtcaca gcaagttcat atccaagcgg 2178661 agaacgctcg tcctctttga caatcccttt tatatagagc gacgtttcct gcgtcactga 2178721 tttagctgtt tggaaaatgc tttcttccac ttccgctttt actacgacac cctgaataaa 2178781 accggtaccg tcccgaagct gtaaaaacgc aattttcccg cttgaacgct tattagcgac 2178841 ccaagctccg atcgttactt cctcacctac gtgcttgtac acttggttga ttgttgtttt 2178901 caacatattt ccctccaaaa caagaaagac attcggaagc tcattgcccc gcgaactctt 2178961 ttatcatcac tttattatac ccgctcttaa ctaaccgggt caatgcagat aaaaagcggc 2179021 ttttctgtca gccgcttttt gatctgttag ctatgttttt ctacaaaacg cttgattctt 2179081 tcaatggctt cttcaagaag atctaacgat gttgcataag aaagacggac attctcagga 2179141 gagccaaatc cggatcctgg aacaatcgca actttttcct cctcgagaag cgctttaaca 2179201 aattcatcta catctttgaa accgcaagat tgagctgcct cttttgcatt tgggaacaag 2179261 taaaaagcac cttccggctt cacgcagctg aaccctggga tttctatgag ctttgcatag 2179321 atcgtattta atctatgttc aaatgcttct ctcatttctt ccaatggctc agaaggcccg 2179381 ttataagcag caatcgctcc gtattgtgcg attgatgtcg ggtttgacgt gctgtggctt 2179441 gcaaggttcg tcatcgcttt aataatgtct tcagagcctg ccgcataacc gattctccag 2179501 cctgtcatgc tgtgggactt cgatacgccg tttataatga ccgtttgctc tttcagtctg 2179561 tctgacagct gtgcaatgga aacatgtttc tttccgccgt atgtaagttt ttcataaatt 2179621 tcatctgaca caatcaagat atcatgttca aggcacactt caccgagcgc agatagttct 2179681 tcttccgtat acatgacacc agtcgggttg cttggagagt taataacgat tgcttttgtt 2179741 ttttccgtaa ttgcattttt cagctgctca ggcgaaattt tgaagtgatt ttcctcaagc 2179801 ccttctacat aaacaggctt tccgccagcg agtttcacct gctccgggta gcttacccag 2179861 taaggcgttg gaataataac ttcatcttct tcatccaaaa tcacttggaa aagggtatac 2179921 agagcatgtt tggcaccagt gcagacaata atttgagacg gtttgtattc aatattctgg 2179981 tcgcgtttaa atttctctgc aatgctgttt ttcagttcag ccaaaccacc ggaaggcgtg 2180041 tatttcgtat ggccctcgtt catcgaacgc acagcggcat caataatatg ctgcggtgta 2180101 ttgaagtcag gctcgcctgc tcctaagccg atgacatcat ggcctgcggc tttcagttct 2180161 ttcgctttcg ctgtgattgc cagtgtggtt gatggtgtta atgcggatac tctttttgcc 2180221 agtttcaact tgaactcccc ctaattcgtc ttaaggcgtg atatttttga gaatctttcc 2180281 agttgtaaag tccacataac ttaaactgta ttgcccttct ttgtctaagt acgtcacttc 2180341 ccaaagcagg acgtttcctt ctcttgccag atgaacctct ttttgctttg aaaccagccc 2180401 ttcatccttt atgattttcg ccgctttgtc ttcagagatt ccctctttcg cttcttttga 2180461 gagaattttt gcttttttat cagcaggaac ccagacatat aatgcagtgc cttttttatc 2180521 cgttcccttt acaacataat atttttcttt tccgacaaat gtttcgactt gatcaacatg 2180581 ggcgagatcg gtttcttttt tagcttcagc agctgctgct tcgtgcccct cttccttttg 2180641 tgccatggct gatttataaa tgcttgccga gacaagaagt actgctaaaa aaataatacc 2180701 aaaaatgacg gtaaatatta atgctttttt tctcatcttc tcacctacgt acgataaatg 2180761 gtaaaaacgg cttggttttt gttttcttca tccagcgcaa ggccgaacat cagattgtct 2180821 cttttcagtg tacgattcaa tgtgtccaca attttataca gatcatcaga atgctctaca 2180881 ttaattgttg aaagaatttc gattttactt tccatttttt catcctccag tttgaacaaa 2180941 tattgttagt catactccat ttcaggacac gccatactag tatcacagag cgggaaatcc 2181001 gcttttaaat aaaacaccat cctactccca caccgcaaaa gccgctttat gcggctttta 2181061 ttctttttcc cctgcaacat aagcttcaag ctcgctgtca gtcatttcgg atactgaggt 2181121 tgtcggcaag gcatcaagaa acagccggcc gtaaccagcg gttttaatcc gtctgtccaa 2181181 tataataatc gttcccttgt ctcccgcaga acgcagcaag cgtccgattc cttgcctgaa 2181241 ggtcagcaca gcttccggta atgacactgt ttgaaacgga ttctttcctt ttttgcgggc 2181301 aagctcacat tttgcagcat gaagcgggtg atcaggggac cggaatggga gcctcacgat 2181361 cattactgtc gtcagctcat caccagggaa atcaacgcct tcccaaaaat gatttgttcc 2181421 gagcaggatc gcctgattgg atgttttaaa agtcttcatc agtttgccgg gacttccgcc 2181481 tgtaatccct tgtgccaaga gctgaatgcc ggaagcactc atgttatgct taagctcctg 2181541 gtgaaccttt ttcagcatat catgggatgt aaacagcaca aggattttag gctgtttttc 2181601 ctttgccatc agttcgatat aacgggctgt atcctgtata aattcaggtt gccctgtatc 2181661 ctgaattgat ttcatttctt ttggaatcat cacctgcata cgctcatcgt aagaaaaggg 2181721 tgactcaatt ctcattgtcc gcgggaaaaa gtcactcagt cccagtcgtt caatcataaa 2181781 ttgaaaagaa ccttcgactg taagagttgc agatgtcagc accacactat ttttgcgcgc 2181841 gaaaaactga tcagccagaa gttcaccagg ttcaagaggc tgtgcgtaaa tggccactgc 2181901 atttttcgca ccctttgcat ctatttcaat ccaaaccgct tcatcgtcat cagagccaaa 2181961 gaagagcttc tgcaacgtct gacagtaatg ctgcaagcct ttcatgcttc tttggtattc 2182021 atcggctaaa aagacggttt tgctcttcat gcccttcaaa tgtttttcca taagggatga 2182081 ctgcgcctca aaaagctgct gcaaatgtgt cagcatggaa caaagcctct ccgcaccatc 2182141 tgttaagatc gaccagcttt tatcctggct ttctttgttc accttaaaca ctagacggtt 2182201 taagtcttct ttaggttttc ttcgtttgac aaaagaatgt acagagctaa agaaagcatc 2182261 actttctgct tgaacgtgct gaagccactc ttccaattcg aaaaatgaat caaccggcag 2182321 gctgtttcgc tggaatagct gtctcatctt ttttagaagt ccctgctcct tcagagtgcc 2182381 gattctgctc aatttcgtat gcaattctat gtacgtggct cttttcccta aatgttcgct 2182441 tgccgcacgt tcaaaatggt gtgcttcatc aataataaat gtgccgcttt cgggaagcct 2182501 ttttttatgg ctgccttcat cggtcagcaa aagagaatga ttggtgatca ccaaatcgga 2182561 acgcatagca atctgtttgg cccgctcgta aaaaccgatc acatgctcac tgcgacttct 2182621 tttataggag tcatcgtcat aagccaatct gtcccacagc aattttccgc ctgaaggcaa 2182681 attcagttcc gctacatctc ctgtatttgt ctctgtcagc caaacaagaa gctgtgcctt 2182741 tgtcagtacg gcatcataat tatcatcttc ttcatgaagc acctgctcaa atttatacag 2182801 gcataaataa tgcgattgcc cttttaaaat cgccgctgtt accggaaatg gaaacagatc 2182861 ttggacaatc ggcaaatcct ttgtgagaat ctgctgctgt aaaagcgtcg aatacgtgct 2182921 gattatgacc ggcttttttg atttcttggc aaaaagcgca gccggaataa gatagccaat 2182981 cgtttttccg atgcctggag gagcttcaat cagcgcatgc tcacgattgg caaacgcatc 2183041 agccacctct ctcatcatca tcatttggcc gtctcttttt tcatacccag gcattaactc 2183101 tgacagcgct ttttcatttc ccgcttccca gctttcgatc tcaaatgaga agttctcgtc 2183161 ctcatttata cgaacatcga tagcttcagg ttctctgaca gaaaacgaag aaaagcgcgt 2183221 atagcccggt atctcggtat gtctgttttc attaatgaac atatccaaca aatgcgtcag 2183281 atcactgatg aaatgctgcg aaagccttct taactgcttt aatgtcggat aaggaagctg 2183341 ccgcagcttt tcaaggattt ccaaaaaaat aagccctgtc acttcagcat cgctgtcagc 2183401 ccggtgcggc tgatcatgcc gcagctgaag ctcctcgctt aattccgtca gcttataccc 2183461 ttcaaatccc ggaaaaacaa tgcgtgagag ctcgacagta tcaagcactt cacaatctgg 2183521 gagctgaaag cccgccttat gtagctcata cttgacaaat ccaaggtcaa aatggatatt 2183581 gtgggcgaca aaataagcgc cgtcaagcaa ttggaatact tcttcagcaa ctgcttcaaa 2183641 tggctgttca ttctcgacca tttgattaga gattccagta agctgctcaa taaaagcagg 2183701 gattgattta tttggattaa tgtattttga aaaccgctca gtaatttgtc cattttcgat 2183761 tacaaccgct gcgatttgta tgattttatc gcctttcttc ggcgaattcc ctgttgtctc 2183821 tacatctata acaacgaacc gttgcttatt cattaaaatg gacacctcaa ttcttgcata 2183881 cgacaaaagt gtaacacgtt ttgtacggaa atggagcggc aaaaccgttt tactctcaaa 2183941 atcttaaaag aaaacccccg ataaaggggg cttttcttct acaaaattgt acgggctggt 2184001 tcgttcccca gcatttgttc aattttgttt tgatcattca gaacagccac tttcggctca 2184061 tggcttgccg cttcttgatc agacatcatt ttgtaggaaa taataatgac cttatctcct 2184121 tcctgcacaa ggcgtgcggc tgcaccgttt aagcatatga cgccgcttcc ccgtttacca 2184181 ggaataatat acgtttcaag acgtgctcca ttattattat tcacaatttg tactttttca 2184241 ttaggaagca ttcccacagc atcaatgaga tcttcatcaa ttgtaatgct tcccacatag 2184301 ttcaggtttg cttccgtaac agttgccctg tgaagtttgc cgctcatcat tgttcgatac 2184361 atattatatt ctctccattt ctcgaatatc aataatgata ttatctatta aacgcgcttt 2184421 tgaaaaagca actgcaacag cgagaatcat ctttccagca atttcattca caggctcgag 2184481 ttccggatag gaataaagct ctacatagtc tatggttccg ctagtcgttt caatgatatc 2184541 ttttgcagct tttatcaccg cttcaggatc tctttcaccg gcttggacaa gttccgcact 2184601 tgtttgaagg gcccgataca gcttaggcgc ttcttttctt tcctcagctg ttaagtatac 2184661 attgcgagag cttttggcta agccgtcttc ctctctgacc gtatcgacag gaaccaattc 2184721 aatatccatg aagaagtcgc tgattaaccc atcaacaaca gctacctgct gcgcatcttt 2184781 taaaccgaaa taggcacgag tcggcttgac tagattgaaa agcttcgtca gtacgatcgc 2184841 gaccccgtca aaatgtcctt ctcttgagcg cccgcataac acgtctgtgc gtctttctac 2184901 atgaatcgtg acattctttt caccgggata catatcatga gcatctggcg taaaaagaat 2184961 atcgactccg gcgttttctg caagagctgc atcccgctca atatcgcgcg gatatgcttc 2185021 aaaatcttca ttagggccga attgtgcagg attcacaaaa atactcataa taacggcgtc 2185081 gttttcttgt cttgctttgt ctgctaaggt taaatgcccc tcatgcagaa accccatcgt 2185141 cggaacaaat ccgattgact tgccctctga atggtattgt tttatggctt ctttcagctg 2185201 tgaaatatca gtaatctgtc tcatcttatt ttcccccgta caagccgtca agcactgtct 2185261 ggttcatttg aaaggaatgc ttttgttcag ggaaagcacg atgtcttaca tcctgaacat 2185321 atccgctgat tgctgtttcg atggtttcat caatgcgcgt atattgcttt acaaatttag 2185381 gtgttctctc aacaccgtgg ccgataatat catgataaac gagaacttgt ccgtccgctt 2185441 tcacaccagc cccgattcca atgaccggta tgcttagcgt ctcggcaatt ttggctgtga 2185501 gttctgccgg cacacattcc agcacaagca tcatagctcc tgcttcttcg cattttatac 2185561 tgtcttctat taattttttg gcgctttgtt cgtctttgcc ctgtacttta tagccgccca 2185621 gtacgccgac tgactgcggt gtcaaaccta agtgactgac tactggaatg cctccaagcg 2185681 tcaatgcgcg aatggattca aacacgcctt ctccgccctc aagcttcagt gcgtcagctc 2185741 cgctttcctg aacgatagcc gctgcatttt tcagcgtatc ttccttagac aggtgataag 2185801 acataaacgg catatctgtc acaataaagg tattcggcgc acccctttta acggcttttg 2185861 tatgatggat catgtccgca actgtcacac cgacagttga atcaaggccg aggacgacca 2185921 ttccaagtga atcaccgact aaaatcatgt caactcccgc ttgttcagca agtttagctg 2185981 ccggataatc ataagcggtc agcatgacaa tcggttcttc agactccttc atttttagaa 2186041 aatccagttt tgttttcatg ttttctcctc ctcatgttta gaggagatga tctgccgttt 2186101 tcttctgcaa gccaaaaaac cttccgttac aacgagaagg attcttcact ttctaaagtt 2186161 cggcgagttt catccctctg tcccagtcct tttttggatc aaggcagact gctgcaatgt 2186221 ctatctattt taataatagg tgcagttcgc aggcgatact gcccaatgga agtataccaa 2186281 aatcaacggg cttgtaccaa cacattagcc caattcgata tcggcagaat agattttttt 2186341 aatgccttcg ttcgtttcta aaagcagaac gccttcatca tctataccta acgccttacc 2186401 gtaaaaggtt ccgtttaacg ttctggctct catattagtg ccaataccga gcgcatagct 2186461 ttcccataaa agcttaatcg gcgtaaatcc gtgcgtcata taatcccggt accgtttctc 2186521 aaagcatagt aaaatatgct ggatgacgcc ggcccgatca attttttccc cagcagcttg 2186581 gctgaggctt gtcgcgatgt ccttcaattc atctggaaaa tcattaggct gctggttaac 2186641 gttaatgccg atcccaatga tcactgaacg tacgcggtct tcttcagcct gcatttccgt 2186701 taggataccg actgtttttt ttccgttaat caaaatatca tttggccatt taatatccgt 2186761 ttggatgcct gctgcctctt ctattccctg cacaacagct actgcagcaa gcagagtcag 2186821 ctgcggtgtt ttttggagcg gaatgtcagg ccgcaaaatc aggctcatcc aaacaccgtt 2186881 tccttcttga gaatgccata ccctagacat tcggcccctt ccggctgttt gtttgtcagc 2186941 caccacaagg gtgccttccg gtgcgttatt attcgcgagc tcatgagccg ttttttgcgt 2187001 gcttgaaaga acgtcatggt aaataagatg ctggcccatc acttccgttt ttaatccaaa 2187061 acgaatttcg ctttcactga gttttccggg ttttttgatg agccgatatc cttttcttct 2187121 aacggcttct acttcataac cctctttccg aagctcttca atatgcttcc acacagcagt 2187181 tcttgaacag ccgagagcat cactgatttt ttggccggaa ataaattcat tgccggcctg 2187241 agaaaataat tcaataaggt cttttcttaa tgttgaccgc atgtcttcag ccactcctct 2187301 atgtgtttct tttgattgga gagcttccct gtcacaacag cctgctcgat ccactgtaat 2187361 tcttctgaca cccattttcc ggccggccgg tttcgaagcg caagcaagtc cttacccgtg 2187421 atatcaagat ccttaaggct tttgatcggc aggttttgat aagcgtactg aatgtccttc 2187481 agtttctttt catccagttt ttcgttttgc cgaagctgcg atattttggc cgctgagagc 2187541 agtgcttttt tcccagctct gtacattgtc attgcgtcaa ggctctggcc aaacgtatcg 2187601 gcaatgtgaa tggcttcctt gatcactttt cccgggagct tccaggcttt caggaaaagg 2187661 ggcgcgtctt tcaaaactat gccaaggtta attaaaagag cagcccaaag ctcctcacgg 2187721 gatgttaaag agaagaatgg aaactcactc gttgaaatca ggttttctcg tttatgataa 2187781 aaaccaggaa gctcttcata caatctcgtt tgaatgagtg tttgaagcgc ctggcgagaa 2187841 gctcttccct gcagcaattt ctcaaactct atagtttttc gttcgactga aacatgggag 2187901 aggagtgatt tttctttcgc aatggcttct tctgtttccg gtgaaagcgt aaagccaagc 2187961 tggctcataa agcgtacggc tctcagcata cgaagcgcat cctcttgaaa tctatcctca 2188021 ggctttccaa cggttcgaat cactttctga tcaatatctt tcttgccgcc aaaataatca 2188081 agcaccttcc cgtccgctgt catggccatc gcattgatcg ttaaatctct gcgttttaga 2188141 tcctcttcta atgatgagat aaattgcact tctgacggtc ttctgaaatc aacataatca 2188201 gattcagtcc ggaatgtcgt gacttcatag gtttcatcct cccagagcac aataatggtc 2188261 ccgtgctctt tgcctacatc aacagtccgc tgaaacagcc gttctacttg atcaggtgcc 2188321 gcatctgtcg cgatatcgac atctccgatc gttcgtttca tatagctgtc acgaactgcg 2188381 cccccgacaa aataagcctg atggcccgct tcgattaaga tgcggagcac gggaagtgct 2188441 ttgataaaaa ctttttccat gtgatcactc cggttctgct aaatcggcat aaatctgttc 2188501 atactggctg acaatttttt tagaagaaaa ttcattttca agcatctcta ttgccgcctt 2188561 tgtaaaacga ttgcttagct gttcatcttc taaaatgctc atcgcgcggg ctgttgcggc 2188621 cgtaacatca ccgacatcca ccaaaaatcc gctcacattg ttttttataa cctcagggat 2188681 accgccaatg tttgttccaa tacaaggcac tccgcaagcc atcgcttcaa gcaggacaag 2188741 gccaaagctt tctttttcag atagcagcag cttcaaatcg ctaatagaat aaagatcttc 2188801 aacacggtct tgatttccaa gcattaagac ttggtcttcc aagccatatt ttctgataag 2188861 ctcgcaggct gtcgatttct ccggaccgtc tccgactaaa agcagcttcg ctttcgtttt 2188921 gccagcgata ttgcggaaca cacggatgac atcctgcacg cgtttaactt ttctgaagtt 2188981 ggacacatgg atgacgactt tttcatctgg taaaattcca tgtttctctt taattgccgc 2189041 tgtgtttttc ttcagataca cgcgctcgtc tataaagtta taaatcgttt caattttttt 2189101 ctccggttta attaaatcgt atgtttcagc cgcaagcgct gaggagacgg ccgtcaccct 2189161 gtctgatgac tcaatagcaa aacggatcag atcttttaga gacggatcat aacctaacac 2189221 cgtgatatcc gtgccatgca aagtggtaac aatgccgata ttgcgtttca gcatttgttt 2189281 tgcaagatag gcgcaaacgg catgcgggag agcatagtga gcatggataa tgtctaaatt 2189341 ctcccgttcc gccacctcag cgattttgct tgccaatgtc aaatcatacg gaggatactt 2189401 aaaaacagca tattgattaa cctcaacttc atgaaaatga atattgggat gatatgtatt 2189461 cagtctaaac ggaatgcttg atgtgatgaa atggatttca tgtccctttt cagcaagctg 2189521 cttccccagt tctgtcgcaa tgatacctga gcctccaacg ctcggatagc atgtgattcc 2189581 tatttttagt tttctcattg ttcgccccca agcacatcat gatcaagcat cagcatccgt 2189641 ttggaaaaga aaccttcggc atactccacg cccgcttctt taccgtaaag cttttctctc 2189701 gcttcaacga tttcaatata cccattcgtc agaggagtag aaacggaatc ctttgacggg 2189761 ataaactggc ttttgtaggc gttgaggctt tgtttctttg cctctattgt atccgagata 2189821 tcaataacaa aatccggctg atgaaaacca tttatcatat aatagtaaac cttgctgact 2189881 ttatgcgccg gaaggctttt ttcgtcttta tatttatgga ttccggcgga aaagatcgct 2189941 tcttccacca gtgcagccgc attgccgtga tccggatggc gatccttttt atacggcata 2190001 aaaaccgctt ttggccgaca gattctgatg acagtgacaa ttgaccgaat tgcctgatca 2190061 ctcattatta ggccgcggtc tggaagcgtt agctgaattc ttttatctgc gcctaatatg 2190121 cgggctgctt cagctgcttc ttctttacgc aaactgaccg taccgttaga agagagttcc 2190181 gcttctgtca aatcgcatat cattactttt ttttcctgtt tgacaaactt cgctattgtg 2190241 ccgcccattc cgatctcgac atcatcactg tgggcgccaa aagcaagaac gtcagcatta 2190301 tacattcggc tcttctcccc gaagaaggtc acggaattcg aaaacacctt catcaagtgt 2190361 gcgcacaaga atttccgcag tacccatatt tgtggcgagc ggaatggaat acacatcaca 2190421 taaacggatt aatgccgaga catccggttc atgcggctgc gcggtcagcg ggtcgcgcaa 2190481 aaaaatgaca agatcgagtg cattggcagc gatcagtgca ccgatttgct ggtctccccc 2190541 taaagggccg gattgaaaac gttcaatttg aagacctgtc gcctcatgaa ttttcaaccc 2190601 tgtggttccg gttgcgtata gatcatgatt ctttaaaata tcccgatagg cagtcgtaaa 2190661 ttgaaccata tcctgttttt tcttgtcatg cgcgatcaaa gcaattttca ttgtttatcc 2190721 ccccgtctaa tcaatgatat tttctaaacc atacacaagc tgatcaatct tcatgacttg 2190781 ttcgactgac agtttaacgc ctgacatgaa agaagcacgg ttataagaat catggcgtat 2190841 ctgaagcgtt tggccatcca tgccgaacat gacctcctga tgcgcgatca gtcccggaag 2190901 acggacgctg tgcaagcgaa taccgttttg ctccgctcct cttgctcctg ggagaatttc 2190961 tttttcatcc ggatgtcctt gctgcttttc tttacggact tctgaaatca tttccgctgt 2191021 tttaagcgca gttccgcttg gtgcgtcaag cttctggtca tgatgaagct caataatctc 2191081 aacatcctca aaatagttgg cagccatttt tgaaaatttc atcatcagta tcgcaccgag 2191141 cgcaaaattt ggcgcgatga tggctccgat ccctttttct tctgttaaag atgtgagctc 2191201 ttttaaatca gcttctgaga aaccggttgt tccgacaact ggacggactc cgtgctctaa 2191261 tgcaattttt gtatgtactt ttccgatttc gggcgttgtt aaatcaatca agacatccgg 2191321 ttgtgtttct gtaaaacagg catggatatc tgtgtaaatg aaagcatctg actcaacagg 2191381 catcacatca gataattttt gctgatcgta tgtatggtct atggccccta caaggtcaaa 2191441 atgtggtgtt cgttctgcca atttaacagc ttcctgcccc attcttccac gcggtcccgc 2191501 aatgactaat ttaattgttt cgtttgacat cttgatctcc tctactttcc ttcttctttt 2191561 ctggtccagc gatctttatc tcttgtatta aatttatgca tgactcggtc gtgagcttcc 2191621 tctaaagaga tatcaagaga gttggctaaa caaaccaata caaatagcac atcgcctatt 2191681 tcctcttcca tgcttttatc atcttcagtc gctttttttg gtttttctcc ataacggtga 2191741 ttcacttctc tggcaagctc gcccagttct tcagtcagcc tcgccatcat ggccagcggg 2191801 ctaaaatatc cttctttaaa ttggcctatg taacggtcta cttcagcctg tatgtctttc 2191861 attgttttat cactcactga acgaaacctc ctatcatcct cttacatgtt agctaattca 2191921 gatacgtttg acaaatgttt aagcacgttt gctgttttct ttttcatcca ctataatata 2191981 aacgctatct aatggaagga aaaggggttt tgtgtgatgc ttggagaaat tagattaaaa 2192041 aacatatttt ttattttaat cggagcggca attttttcat ttggcttggt tcatttcaat 2192101 atgcagaaca atctggctga gggcggtttt acaggtatta cacttttgct ttatgccctt 2192161 ttccacatca gcccctctat atcgaacctg gtgttgaaca ttccgatttt ttttattggc 2192221 tggcgtttgc tcggcaggac aatgtttgtt tatacccttg tcggcactgt agccttgtct 2192281 ttgttcctca gcatctttca gcgatatgaa atccatatgc cccttcagca cgacttagcg 2192341 ctcgccgctt tatttgccgg cgtattcatc ggagccggac tgggtattat ttttaagttc 2192401 ggcggtacga caggcggtgt tgatatcatc gcacgtttag tgaataagta ttttgggatt 2192461 ccgatgggca gaacgatgtt tgctttcgat gcctgcgtca tcattttgtc tttgcttact 2192521 tatctctcct ataaagaagc gatgtatacg ctggtagctg tatttgtagc ggcaagatta 2192581 atcgatttta ttcaggaagg cggatacgct gctaaaggcg ctacgatcat ctcttcgaaa 2192641 aacgacctga ttcagaaaaa gattcttgaa gaaatggaac ggggcgtcac cattttgaaa 2192701 ggacaaggtt cctacacaaa agaggatata gatgtacttt attgtgtggt gccgaaaaat 2192761 gaattggtga tgctgaaaag cgtgattaac tccattgatc cccatgcctt tgtagcggta 2192821 agcgatgttc acgatgtgct cggagaagga tttacgcttg atgaaaataa aaatccgctt 2192881 ccgcgctgac atgtaataga aaaaaggcgg ctgaccgccg cccctcatcc ttatttaggg 2192941 tagtcccttt ttttcagctt gtttttttcc gccttgtact ttctgtaacc gacataggta 2193001 agagcagtaa tgatgatact gccggttgta atgatcaccc agagtaaaga cggatcggca 2193061 tcatcctcct ccaccctgtc aaacacattt ttcaggtcat gctgaagaag ggaaagccgt 2193121 tcaagcttcg tgctctctgt catttgctga aattcctctt gctcaataac atctatatgt 2193181 tttccgactg tttcaagctg atcctctgat acatcgattg taagactggg gtaaatcaag 2193241 tcatataaac tgataaattc attccatttt tcatgaaagc ttgtgcttcc attcttttgg 2193301 acatctcgct tcagttcagt aaaagcttcc ataatcggtt tttccagtga gccccaaagc 2193361 gggtcagacc gattgtcaac cgcatccatc agcattctga actgcgcggc tgctctgagt 2193421 ttttgtgtgt ctgatgtatc agcttgcttt aaactccgaa ccatatcatt atagcccaat 2193481 gtgatttgac gaatttgggc tcccgttagc atggggtctt gctgtttttt ctcagcggat 2193541 tttaatgttt tttcaaaata ctccaagact tgaagcgcct cttcatattt cgcctgtcgg 2193601 gtcatttgaa agactgtatc ggataaatca ttcaattcct cgaggcttcc ccgctctgca 2193661 gccttggcat ttccattata aaaaataagt gcaatcaaca aacagatcgt cagctttcgt 2193721 ttcatgcagg tccctcccac tctctctcct tacagaatat gaagaaaggg acaaggatag 2193781 accaacattg tctttacatc agctcaagct tcgtttgctt ttttgagacc acaagaaagt 2193841 aagcaagcgc gattgaaaag atacttagcc aaaatgttcc gtatcctatt tcagtcatat 2193901 aatcagaaag catagagtat tgcggcatca tatcaaacaa gtagtcaatg acatcgttat 2193961 gcagtgtcca gactgcagca attgcaagat gccaaaatga aaaacgaaaa tacggactgt 2194021 ataatacgcc ttgaactgcc attgcaaaat gcgaagcaat tagcatgtag ccctcccacg 2194081 gcaagtcacc agttactgca agcacaagaa aattcatagc caccgcccat aggccatact 2194141 ttacgagggt aactagcgca agcgcctcta aaagcggagc attccgtttc atgagaaagg 2194201 caagcagcac aaacagaaag aaaaacgttg ctgtcggact gtccggaaca aaaatcagga 2194261 aacgggccgg tgtctccaaa agctgcggca agtaccaata gtagccgtaa accgttccca 2194321 gaaaattaat ggctaagaca agaataagca tcggccgctg ccctaataca tattgaaacc 2194381 atttcacatc gaatcaactc tcagtctgta aaaataatat gtccatataa aaaagctgac 2194441 gccgggtcag cttttgataa taaaagtata tccttccatt tgacaattca caatacgtta 2194501 ttttgcggtt gtttcagaaa taaattttgc aagttcttcg agctgcttat catttccttt 2194561 gaacacaccc gccggcattt tgcctttccc ttctacagcg atttttttga tttcatccgg 2194621 tttcagcccg ctgtcaacca atgaaggccc ggccgctcct ccctgaaggt tatccccatg 2194681 gcaagaaata cagccctgtt ccttaaaaac cttatatcct tctgcattgg tgtcaatgtc 2194741 ggcttctttt gtaattttcc cctgttcttc tgccttggcc cagtcatgag tagcaactga 2194801 ctgccacgtc aaaaatacag cagcggaaat ggccagaagc atcataccga cagcgaccgg 2194861 acgcttccac ggccttcttt ctgtccctct gtctaggaat ggagccaaaa gcagggcccc 2194921 aaaagcgaga cctggcataa tcatggcgcc gaccactgta aagcttccgg cggcgtattc 2194981 atacttcaac agctggtata agaaaagaaa ataccaatcc ggcagcggaa tataaccagt 2195041 atcagtcggg tccgccatcc gctctaaagg cggctgatgc acaatcgtca aaacgagaaa 2195101 accgatgaga aagacagctc caaccatcca ttcctttaac aagaaatttg gccagaaagc 2195161 ctctgtttta cccggatact ccgaataatc cttcggtata ttcggctttt tttcagccgg 2195221 tatccttgag tcgcctacaa atttcatccc tttgccccgg tgcatgtcat cccctccctt 2195281 ttattcgcag atcaagagtt taaagcggtc ctgaaatccc ctgcttccgg atcataataa 2195341 aatgtgcagc catcagcccg aacaatgcgg caggaagaaa aaatacatgg atcgcaaaaa 2195401 acctagtcag cgtttgggcg cctacaatat ccggatgccc tgcaaggagc gttttaactt 2195461 gcgttccgat caaaggcgtg gcttcggcga tctgcagtcc gacttttgtt gcaaacagag 2195521 ccttcatatc ccaaggaagc aagtagcctg taaagccaag accgagcata acaaaaaaga 2195581 tcagcacacc gacaatccag ttcagctcgc gcggtttttt atacgcgcct tggaaaaaga 2195641 ccctcagcgt atgtaaaaac atcatcacaa tgaccaggct cgcaccccag tggtgcatcc 2195701 ccctgacaat ctggccgaat gccacttcat tttgcaaata atataccgat tcccaggcat 2195761 ttttgatatc aggcacataa tacatcgtta aaaacattcc agataatact tggataacgg 2195821 ttacaaaaaa cgtcagtccc ccaaagcaat acacaaacgc agagaaatga tgggcgggat 2195881 tcacatgttc cggtacttcg tgatcggcaa tatccctcca catcggtgta atatcaagcc 2195941 gctcgtctac ccagtcataa attttgttca gcatgtcacc cttccccctt aggctttgct 2196001 tttccaagat acaggaagcc gtcttttact tcttgctcat aatgatcaag aggcgcaagc 2196061 ggcggcgtgc cagggacatt ggtgccgtcc ttttcataga gtccgtaatg gcatggacaa 2196121 aagaatttat tcgggttttt aggatcacta ttccagttca ccgtacaccc taaatgctta 2196181 caaattggcg aaagtgctac aatttcatcc ccgtttttga agacccaggc tgatcttgac 2196241 tcttctgact cataccaggc atcgacttga ttaattttaa aatcaaagcg ctgcggctct 2196301 tttgtcaact catcaacgct gacaacctga accatatcct gcttccctgt cgattttaat 2196361 accgggtcga gtgcgaagcg aaccataggc atgagcatac tagccgccat aaaacctcct 2196421 acgcctgtga gcgtataatt caaaaattga cgtctggata tatcatgttt tccgcccatc 2196481 tcttctcccc cctctaagtc acccctgcaa actgactaaa atagaaaata ttgcaataac 2196541 tctagacacc ctcataatat atgaatctct cagcaaggtc aatatagcca aaatattgtt 2196601 tataaggaaa tgtaagtgtt tttataaagt gctccataac tgtaacaaaa cgttcaaaat 2196661 ttcagcagtg cgttcatcca atatttttct ttttaaagag tcatttaaat gctctaatgg 2196721 aacagacgat gtaacaatca ttttgcctaa cgcatcctca gctctccaac tttcgtcaga 2196781 tgtgagcagg acaacatgcg gaaattccgt tatcagctct tcccgcaaat ccttaagccc 2196841 ttgaacggtt atttcatttc tatcaacata tgtataaggc ggaagtaaat atacccgtcc 2196901 ctttaactgc ctttcaagtt cttctgagag aagctgcgta aactcgcctt tctccgccgc 2196961 cattttaaaa tggttattaa cccttatgtt aattaatggt atgacagcgg tatcaatgta 2197021 atccttagct tgtaaatagt ccttggcatc agtgattctc cacctcatcg ttctccccct 2197081 ttacggcaac aagccttgca attcactgca aggctggtca tattatgtga gctgatttaa 2197141 ttggcgcgat aattgttcaa atgcctcttt atcatgacga tctaacgcgt cgtcaatgtc 2197201 ttttaataat ttttctcttt ggaatgtgga aatagcgtgc tctaaaatct gttccgccaa 2197261 tccctgatct tttttattct caaaaaggtt tttcggaata tgcgggttgg actccagcac 2197321 cgccgcatat tcaggtgagc tgtaagccga acggaaatta agctggataa acaaatcctg 2197381 ctgtttattt aatctaatat catgaaaaga tttttccgcg tcggtagtca tgacattctc 2197441 tttatagaac cggaacggaa cttcttcaac acaatgtgtt gacattataa tgcctctcgg 2197501 gcaaaattca gcctgctcca caaaatgaac cttctccatg agagaatcat ggctcattaa 2197561 gtagttcaag atccaaacgc actctcggcg ctttaactga taatggttta aaaaccaacg 2197621 gataaaatct tttttctcat tgacagaaac aggggtctgc atgtaattcc ctcctctatc 2197681 gttcgtataa tctatatact tatatgttcc acatgaatgg ttaatattcc tgcttatcta 2197741 gaaaattcat cctcgattcg caaaatcgtt tcttcaagct cttcattggc tccgtccatt 2197801 tcaagaacct ttttcaaaag cggcagcgct tctttttgaa gaccttcttc taataggaag 2197861 cttgcgtatt catataagaa atctctatcc tcccggtaat gaagataggc agcctcaaag 2197921 gattgttttg cttcctcgta ttgctctaat tcagtatatg cgcttgcaag ataccaattg 2197981 tatttaggat cttcttcacc gtagcttcga acctcttgaa taagatcaat gatctgatca 2198041 taatcctctt ctttgtgata cacggcaaga agtgtatgaa gcgcctcgac aaagcccgga 2198101 tcaagcgcaa gcgcctcctg aagcagcttc ttcccctctt ctgacttccc gattttcaag 2198161 gccattttgg cggcataaag gaaaagttct ttgttatatt catcatatct gatcccctct 2198221 tttgccgttt ttaatgcctc ttcatacatt ccttcagctt catagctttt cgagagcggc 2198281 atataaagtg aagtataaga tggatcaagc tcctttaaat cagacagctg cttaatagct 2198341 gttttcacaa gccccgcctg taaggctgta aaaccatagc cgaaaatcgt attaggatca 2198401 ggattctcat cgacagcttt ctcataccat ggaatggcat cctcaaattc acctgaggca 2198461 cttaacgatt ctgccagtct ttgatggaca ttaacgcccc cgatctcact ctgctcctca 2198521 gccgttgttt taaaatattg aaccgctttt gcataggctc cctgagcaaa gtaaagttct 2198581 cccagtgcaa aatcaataac aggttcattg tccagaatgg actttgcctg gaaaagcttt 2198641 tgttcactga cttcgaataa cccctgcatc tgataaagat ccgccataag cagcaaactt 2198701 tccggatatg atggatctgt ttccggaata gtctccagca cagcgagggc tttttcttct 2198761 tcgtcaatat ctattaaaag ttcagcgtag aaattcgtca gttctgtttc atttggatat 2198821 aaatcatgta gatcactaat cagtgaaatg gctttttcta catcgcccca ctcgtaataa 2198881 agctgggctg caatggcttt atcttcatca tgcagctgtt tttcagcctt cgagagcgtg 2198941 ttgaggcctt tttctgtttc acctgcttca actaatttta tggcttcttg aatcaatgta 2199001 ttcaaatcgg accggtcctt tcttttccta tacaacatca accatacaaa aaaagcttta 2199061 tttgttcggg ttaatcttat cataattcag acgaatgccc ccggcaaata agatgcttct 2199121 gtacggaagg gaattattga gtcttattag tttaccaaaa gatcttgaga tagaaaatga 2199181 aaaaaggaag atcgccctct gtacagtaaa gcagctcttt gacctgccgg cttgtaagta 2199241 aagcacatcc ccccttttcg tttttctatc cgttctataa gacaagctat gttttttcgc 2199301 ctcgaattat gatctgcata aaaaatcctg aagtaaaact tcaggatttt ttcgaaagct 2199361 tatttaaatg ctcgaagaag gttggataag aaacgtgaat ggcatccgtg tgctcgattt 2199421 caatcggctc ctccgttata caggaagcaa taccaagcat cattccgatt cgatgatctc 2199481 cgtggctgga cactgcagcg ccgcctttca acgtttgttt gccataaacc ttcattccat 2199541 ctgctgtcgg ttcaatttca gcacccagct tgcgaagctc agaaacaaca gtatcaatac 2199601 ggtttgtttc tttcactttt agctctgccg cgtccttaat aacggtggtt ccttccgcct 2199661 gagtcgcaag aagcgcgatg atagggatct catcaattaa acgcggaatg atatctcctc 2199721 cgatttcaac tgcctttaga gatgacgttt ctataatcaa atctccataa ggctctgcac 2199781 cgctatcagc agatggtttg atttcaagtt ttgcccccat gttttgaagg acatcaataa 2199841 tacctgtccg agtcggattt aaacctacgt ttttcaatac aattctgctg tttggaacca 2199901 tcgcgccagc agcaaggaaa aacgcggctg aagaaatgtc tccaggaaca aaaatatcag 2199961 cagctgtcag tttctggcca ccagcaatgg aaacactcgt ttgatcttca gaaagcttaa 2200021 cgccaaaagc agaaagcatc cgctcagtgt ggtcccgaga tttatggggc tctgttacag 2200081 ttgttgtgcc ctcagcctgt aatccggcca gcaaaacagc agatttaatt tgcgcgcttg 2200141 caacaggtga tacataatca attcctttta atgaagcgcc gctcactgac agcggtgtaa 2200201 actctccgcc ggctctgccg tcgattttag cccccatttt tttcaaaggc tcagtcacac 2200261 gcttcattgg gcgtttcgca atgctctcat ctccggctac cgcgctgtaa aaaggacggc 2200321 ccgccaatat tccgagcatc aggcgaatcg ttgtacctga atttccgaca tctaaaaggc 2200381 tttctggctc tttcagggca tcgattcctt ttccgtgaat cacgacatcg ctgctgcttt 2200441 gctcaatgtg aacacccatt tttctaaagc aatcgatcgt gctcagacaa tctgctcccg 2200501 gcagaaagtt tttaactgtt gttgtgcctg ccgctagcgc gccaaacata acagagcggt 2200561 gagaaatgga tttatcaccg ggaatatgta tttctccatg taaggtctgc accttatctc 2200621 gtttcatttt ttccacctca atcagcataa aaagtttcat attccgcccg ggcttcaatg 2200681 cattgttctg cccttttgcg gtcgtcatca gactgaaaac tgatccttaa aatcccgtta 2200741 atatcctctc gtgtttcgat aatgcggata ttcgtgatac tgatgcgctc cgcagctaag 2200801 atcgctgtta tctcggatat tacacccgga tgatcgggta catccacata taaatcataa 2200861 aatgcaggta tcgctccctt ctgccgaagc ggcagcccgt cgcgataatc cttggctgtt 2200921 ttaaaataac gaaatagatt ttccgcatct tcttgttcta catatgtacg gatcttgtca 2200981 atttcacgaa tccactcatc aaaacggtct aagattttat ctttattatg taataaaata 2201041 tcccgccaca ttgccgggct gcttgatgca atccttgtaa tatctctgaa cccgccggca 2201101 gcaaaacgct taacaagcgg atacaggttt tccgaatgat gggtttggtg aacaaggcta 2201161 gctgctacaa tatgcggaaa atgactgatt acgcttgtaa cgccatcatg ctcctctggc 2201221 gacatttcca caaaatgggc attcgtcccc ttcagcaggt tttttaactg ttccacagct 2201281 tgtttgtccg ttttctggcc tggcgttaaa atataaaatg cattttcaaa caggaactcc 2201341 ttcgcagcgg ccactcctga tttatgtgaa cccgccatcg gatgccctcc gacaaattga 2201401 tagcggctag gcagcacttg atcagcgtaa tcaaccactt tttgctttgt gcttcctaca 2201461 tccgtaatca aaagctcatg ttcaattcct gaatgagcca gctcttcaag cataaccagt 2201521 gtttgttcaa caggtgtcgc aatgattact gtagctgcct ctttcacacc gctaataaac 2201581 gaatcagcac gatcgtctat cacgcctaat tttaatgccg ctaccgcctg ttcatcagag 2201641 atgtcgattc cgataatccg tttgccggga tgattttttt tgatggctag ggcaatcgaa 2201701 ccgcctatca atccgagacc ggcgagcaat attgtatctt tcatttgatt catacgtcat 2201761 cacctggttt atagactaaa gaggtgatat ttgatcacct cttataaaat ttcagctaaa 2201821 atggcaagta tttcttcatt ttgctctttt gttccgatcg taatccggag tgatgtcggg 2201881 aaacctaatg cgtttcctga ccggacgata tagccttttt ccagcagagc ctgaaacagt 2201941 tcatcagcag gacgtttaaa gtcaattaac acaaaatttg tctgtgaagg gtagcacttt 2202001 aaaccatgag ttttcgcaaa atcataatac tgctgaaggc ctgcattatt ttgctcgaca 2202061 caggaagcaa taaacgcttg atcatcaagt gctgcaatcg ccgcagcctg gcccagacgg 2202121 ctggtattaa acggctctct cgccggctca atctggcgaa tcaggttctc gtcagcaatt 2202181 ccgtatccga ctctgagcgc tgccagaccg tatgcctttg aaaatgtgcg caaaatcatc 2202241 aaattggaat acttgcttaa gagcggcacg gtttccgggt aatcctctgc tgttacatat 2202301 tcataatatg cttcgtcaag aacgacaagg acacgagaag gaacgcgctc cagaaatgcg 2202361 agtaattctc cttcagatgt ataagtgcca gtcggattat tcgggctgca tatccaaacg 2202421 acttgtgtct gttcgtcgat ggcttctaac atggcgtcta aatcatgtga gccgtcggga 2202481 cgaagtgcaa tttcacgtac ttcagcacct tcaataaccg cattatgttt atattgcgga 2202541 aaagtggggg cagcagtaac cgtgtttgtt ttatcgttta aaaatgcccg gcagatgatc 2202601 tgtatgattt catcagaacc gttgccgaaa ataagtgatg tttcgctgac attgaggtgc 2202661 ttactgagcc ttgtccgcaa agcggcgcta tacccgtccg ggtaaagggc tagctgttga 2202721 atctcatgat gaagcgcctc ttttgcagcc tctgaacagc cgtaaggatt ctcgtttgaa 2202781 gcaagcttca caactttatc caagccatat tctgatttca ctgcttcaat cggctttcca 2202841 ggctgataag gcttcagctg ttttaaatgt tctttgatac gcaaatcagt cacctcattt 2202901 taaactgtac aagccgctaa acgccattgc ataatcctca aactcctgca gcgcctgatt 2202961 tctcgtttca gcgctgatga gccggtcctt taattcttct atttttctga cgagcgcact 2203021 tcccactacg acaccgtcac taatttcatt catctttatg acctgttcac ggtttgatat 2203081 accgaaccct acagcaaccg gaacagtgct gagattcttc acagtacgaa tgaacgggta 2203141 cacggatgaa ttgaactcat tgcggacacc ggtcacaccc agagaagata cacagtagac 2203201 gaacccctcg gcttgttcaa taatggtttt caaacggctt tcgcttgtcg gcgcaactaa 2203261 agaaatatac gtcacctcat ggcttttaca ttcctcttga aggctgttgc tttcttctaa 2203321 tggcagatcc ggaacaagca gaccgtcaat atgattttcc cgcagtaaag cgaaaaagta 2203381 ttctttgttc aattgtaaca caggattata atacgtaaag aggataatcg gaatattcac 2203441 tccgtttttt ttcatttctc cgcctaattc gattgccttt acgatattca ttccttgatc 2203501 aagcgcccgc tttgaagccc gctggatcac cggaccgtct gcaagcgggt cagagtatgc 2203561 aacaccaagc tccaatgctg tggcgcctgc tttttggagt gacttcgcca gttcaatcga 2203621 aacctcagga actggatcgc ccgccgtaat aaacgggata aacaattttt ctgatggttg 2203681 aagatccaat ttaaacatgg gctttcacct cttcttccaa tacattcatt aatgtgttga 2203741 catccttgtc tccccggcct gataaacaga cgagaatgag ttgaccgcga tccattcctt 2203801 tggcgagttt gaatgctttc gctaacgcat gggcagattc gattgccggc aaaatcccct 2203861 ctttttctga caaaagcttt aatgcatcca ccgcttcttc atcggttata ctgtcataag 2203921 tgacacggcc gcttttatgc aaatatgcat gctccggacc gattccagga tagtcgagac 2203981 cggctgaaat agagtagggc tcaataattt gcccgaactc atcctgaatg agataagtca 2204041 atgaaccgtg aataacccct acggttcctt tcgaaatagt ggcggcatga agaggtgtat 2204101 caattccttt tcctgctgct tcagcgccga tcagttcaac atcttcattt aaaaatgcct 2204161 gaaacatacc catcgcattg cttcctccgc ctacacatgc cactacttta tcaggcatag 2204221 tgccttcaat acgtttcaac tgatccttcg cttcctctcc gatcattttt tgaaattcac 2204281 ggaccacttg cggataagga tgcgggccga caactgatcc aatcatataa aagtgatcct 2204341 cacaatgctg aacccagtac cggatcgcct catttgtggc atccttcaat gttccgtttc 2204401 cgcttgttac aggcactacc tccgctccaa gaagcttcat gcggaaaacg ttcagagact 2204461 ggcgggcaac atcctcttca cccataaaca cagtacagga aaagccgaat ttggctgcaa 2204521 ctgttgcagc ggcaacacca tgctggccgg caccggtttc agcaatgatt ttcgttttgc 2204581 ccattttttt agcaagcagc gcttgaccta gcgcattatt gattttatga gaacctgtat 2204641 ggtttaaatc ttctcgtttc aaatagattt tcgcgccgcc taagtattca gtgactcgat 2204701 cagcgtatgt taatgcagtc gggcgtccgg aatagtcctt taacagctta taatactctt 2204761 cacgaaaagc gggatcatcc ttgatttgtt taaatgctgt ttgtatttca tctaacggct 2204821 gcatgagtgt ttccggaaca aactttccgc caaaatcacc gtatctgcct atttcattcg 2204881 gatatggata catatcggtt catcctttct tctaaaagcc tcatcagatt ctgatctttt 2204941 tgtccgtttt tttcaattcc gctggcaagg tcaattcctt ctggctgcca tttcaatagg 2205001 cgtgtgatgc tatccggatt cacgccgcca gcgataaagc agcgtttacc aatagccgcc 2205061 tgctgatatt ccggcacaca ttcccaagaa aatgcaacac cagttccgcc tctagaccct 2205121 tttacagatg aatcaatcac aaagccgtca acattatctt taaagcgggc tatttcttga 2205181 gttgtgttat cttgatggtg aagcgccttc catatttcac agcctgtcag cttgcgaaga 2205241 gcagcagcat ccgccggttt ttcatcaccg tgaagctgaa tgacgtcgag cttcaagctc 2205301 ttggcaatac gtgacatcgt ctctattgat tcattaacaa aaacacctgc aacctgtttt 2205361 tcgacacgaa cttggttcag ccattttttc acatcttccg gagatacttt tcgtttgctt 2205421 tcagcaaaaa taaatcctag gtaatcagcc tgtgattccg ccgcaagctg caaatccttt 2205481 agtgaccgaa taccgcaata ttttaatgcc ggtttcttca caacctcact ccctaaacaa 2205541 agcatggatt gctttacgct gagaagtttg tctcatcaat gattcaccga taagtacagc 2205601 tcgcgcccca tgttcattga caaatgttaa atgttctaaa gaaccgattc cgctttcgct 2205661 gacaagcaag gattctttcg gaacgagaga tgcgatttgt tctgtctgct ttacagatgt 2205721 ttcaaacgtt tttaggtttc gattatttac gccgagaatg tcgggtgtga acactttcaa 2205781 tatttgttct agcgttgatg catcatgaac ctccactaac acgtccatcc ccttttcacc 2205841 tgcttcaaga tataattcat gaaggtgtaa gggatcaagc acctcgccga ttaacaatat 2205901 ggcatccgct ccgattcttc ttgattcctc tacttgaaga gaatcaataa aatcttttct 2205961 aagtacagga atcgaaacag cacgctttac gtctgataaa tagctgtttt ccccttgaaa 2206021 aaacggggtg tctgttaaaa cggaaatcgc atctgccttc gcagcctcat agtcttttgc 2206081 aatctgcaca ggtacaaaat cctctttaat aagccctttt gacggcgatg ctttcttcac 2206141 ttcggcaatc aacccgataa accgattcgg gcttgccagc gcctccttaa atgaacgttt 2206201 ctcgaaaggc tgctctaccg gcagaaccag tgttttcact tcttctttct tttgtttgat 2206261 gattttttca agcatagatc tcttcctctt tctgctttag tcgttcaagc tgcgcggcag 2206321 cgcctccgct tgtaatcgtc tctaacgcca gctccgttcc ttccttcagt gaggcggtaa 2206381 ttcccgccgt gtaaatcgca gcacccgcat taaaagccgt aatagataaa gcggaactgc 2206441 tgcttttatt ttcaaaaata ttctgaatga gataagcgct ctctttcgga gactgcacct 2206501 gtaaatcttc aagtctgcca tttgtgaaac cgaaatcttc gggtgaaacg gtatactccc 2206561 ggcgctctcc gtcctttaat tcaatcacgt cggtcggtgc tgtaattgaa agctcatcta 2206621 aaccgtcacg gcttgataca aacataacgt gcttcggctg aaacgtctcc agtgcgcttg 2206681 ccatcagtcc agctttttca acagaataga ccccaatcac ctgacgcttc gcctgtaaag 2206741 gattgctgag cggcccaagc agattaaata ccgttctgaa acctagctct tttctagtac 2206801 ctgctacatg tttcatagac gaatggtaaa gcggcgcaaa aagaaatccc atgttgtttg 2206861 tttcaatgct gcttttgacc ttttcgggag tggtttgaat agaaacctct agctcctcta 2206921 aaacatcagc gcttccgctt ttagaagaga cagagcgatt gccatgctta gcgattttcg 2206981 caccagctgc cgaggcaaca attgccgagg ccgttgagat attaaaagtg gaaataccgt 2207041 ctccccctgt tccgcatgta tcaacaatat caggaagtcc atcgactgta agagcgtgtg 2207101 cccgcattgc cttcacaaaa cccgcaagct cttctggcgt ctccccccga tgagcaagaa 2207161 ttgacaatat cccccccatt tcagaaggag tcatttccgc tgccatcatc atattcatca 2207221 gcgtttcagc ctcaccggca gtaagggttt ttccgtcaac gcacaattgt agaaatctgt 2207281 tcatcagctt tatcctcctt gctatgaaac atgtcttctg caatatgaat cgttttcagc 2207341 agcgcaccgg ctttattaca gctttcttcg tattcggctt ccggaacaga atcagcaaca 2207401 atgccagcac ctgcctgtat cgatgcaaca ccgttcttta cactcatcgt gcgaatcgta 2207461 atacaagagt cgatattccc gtcaaaccca atgtaggcaa tacaccctcc gtatgtctct 2207521 ctcggtgttg gctcgagttc ttgcaaaagc tgcatggcac ggattttggg tgcgcctgtt 2207581 aaagtccccg ccgggaaagc agacatcagt gcatcgacag gatgaacccc ttttttcaat 2207641 cggcctgtaa ccaccgagat aatgtgcatg acatgtgaaa aggaaacaat ttttgtgaac 2207701 tccggcacag aaacagaacc atactctgct actctgccga tatcgtttcg ggcaagatca 2207761 acgagcatgt aatgctccgc tttttctttt tcatccttca tgagctcaac cttcagtctc 2207821 tcatcttcag ctttgtctgc accgcgtttt ctcgtaccgg caatcggatg gatttctaag 2207881 tgcccgtctt gaacgtgtat taaccgttcc ggagagctgc cgactatttc tctgtctagc 2207941 agtttcatat aatacatata cggcgaagga ttgacgatcc taagcactcg gtataactca 2208001 aaagcatctg cttttatcgg cacctcaaat ttttgtgata aaacaccctg gaagatatcg 2208061 cctgctttta tatagctttt gattttttct acatcagcca taaaagccga tttttcataa 2208121 ttagaagata ctgtctcaaa gctgggtgtc ttgtatgaat cagcagaaag aaacagctct 2208181 tttatgtttt tttggtccat cattttttca atgagatttt gaagctccag atgattttga 2208241 tggaatacat ccattttttc gttttttgtt tcctctccag tgagccttgc atattggata 2208301 aagtggacgt ttttggtttc atgatcatac gcaattaatg tccggcaaac aaacagcata 2208361 cacttttcca tgtctgtttc tttggtatgc gaaggaacag aaggctcaat cagcgggatc 2208421 atatcatagc ttaagtaccc gacagctccg ccgacaaaag gaatgccaag ctcaggtgtt 2208481 ttgattttgt atgtggtatt catccagttc agcacttctt ttagttcatt tcctgtgtaa 2208541 agagatttgc tgtcctgatc agcggccgaa aaacggccct gctcttcttt aattgtgaga 2208601 aatggattca ggccgataaa cgaatatctg gaccaagtgg atgtatcgtc cttgctttca 2208661 agaagatacg taatctccct gtcaagcttc tctatcattt gaatgggtgt cagtgtatcg 2208721 actgtgaagg tctccacaat cggtatcgtg tggtgggaca agctgtcctc taaaaatgcg 2208781 gaaatgtttg attggaaatt cattgctctc actccttatg gcaaggagaa tgagaagatg 2208841 gcatgagagg ataaaatact atataacaaa taaacccaaa agaaagactt cttttgggta 2208901 gaataaacat aatgtctcag ctcaactaaa ctcattctct gctaccctat tctctaactc 2208961 aactcattct aattgcttta tacacactct tgtgtatttc taagctgttc ttatcgtatt 2209021 acaattcagt attttttgtc aatgataaat cgggcctcaa tacgacaact ttttctaaat 2209081 atacatgtct gatctgatcc tgagggacat ctgtctggac cgtcatcatg actcttatgc 2209141 actttttcag accgcctgtt acgtccattt cctgcataca tgttaccggt acatactgcc 2209201 atcctgaaag ctcgcgaaca gcttttgccg ggaaaacagc gtgcaaatca ggtgtagccg 2209261 acagaagcat ttgaacaaca tcttccggtt ttgtatgatt ttcttctatg attttctcta 2209321 acagctgttt agttttttgt aaaatttctt cttcagtatc ccgttcaact gtagttgctc 2209381 cgcgaattcc gcgaatcatc atgatgtctc ctccaatcgc catttgttca gccagctctc 2209441 aagttcattt ctggaaaatg tatgatcagc aactttccct aattcgttga gcacaataaa 2209501 ctgaatcttc ccgccacggg ttttcttatc attcatcata cggttcaaga gaaccgaagt 2209561 ttccgtctct tttctgattt gacttggata acccaggctt tttagccagc tgaccaaacg 2209621 ttttctgtcc atttcacagc ctacagtctt ttcgcttata tataaagcaa actgcattcc 2209681 gagggctacg gcatcaccgt gagtgatctg cccatatcca tattccgcct caacggcatg 2209741 gccgagcgta tgcccaaagt ttaagtaagc tcttatcccc tcttcttttt catcctgctg 2209801 aacgacagac gctttaattg aaatgccttt aaaaatcatg tcattcagct gatcattagt 2209861 gatatcacgc agtgagtgga tattcagcag ctcctccaga aacgctctgt catagataaa 2209921 agcgtgttta atcacttctg ccattccgga cctaagctct ttttcaggca gagaacgcag 2209981 gaaatctgta tcatagagca cggctttcgg ctgataaaac gcaccgatta gattttttcc 2210041 aagcggatgg ttcacggcta cttttcctcc gactgcgctg tcatgcgcca agagcgtcgt 2210101 aggcatttgg atgaaatcaa tgccgcgcat aaaagtggca gccacaaaac cggcaagatc 2210161 ccctacaaca ccgccaccga atgcgatgat gcatgaggag cgatccatat gaaaacgaat 2210221 cgcttcactc tgcaattttg tgtacatgtc catggatttt gcctgctctc cactcggtac 2210281 cgtcactttt ttcacaggcc atttttcttg cagcaaatgg agcatttcat caccatacag 2210341 gcggtccact tcttcatccg tgacaaacat aatccttgtt aaaggcctgt ttaaagaggt 2210401 taatagttcg caagcctttt ttctgatacc ttgtccgata aaaacaggat atgacgagga 2210461 agcagtttga acatgcagtg tcttcattaa aattccctcg acagttttct catattctcc 2210521 acattttctc taatgcggtc aatttgatct aatccgaatt gttcaacgac tgcgttcgca 2210581 atttcccaag cgacagccgc ttcagcgact acacttgccg caggaacagc acagctgtct 2210641 gaacgttcaa tgctggcaga aaacggttct ttcgtttcaa tatcgacact tttcagcggt 2210701 ttatacaaag tcggaatcgg cttcatgact ccgcggacaa caatcggcat ccctgtcgtc 2210761 atgccgcctt ccagtccgcc aagtctgtta gtagcacggg tgtatccttt ttcctcgtcc 2210821 caaatgatct cgtcatggac ttcgcttcca tttcgccctg ctgcctcaaa tccgatgccg 2210881 aattccacac ctttaaatgc gttaattgac agaacagcgg cagcaagctt gctatccagc 2210941 ttgcggtcat aatggacata gctgcccacg cctaccggca ttccctcgac aatgacttct 2211001 actattccgc cgatggaatc tccgtttgcc tttgcttcat caatggcagc catcattttt 2211061 ttgcctgcct cttcatcgta gcatctgaca ggagactctt ccgttacacg ctgcaagtct 2211121 tcaattgacg tatactctgt tttttcagct ttaacagcgc caatttgcaa cacgtggccc 2211181 gccaccttaa tgccaagctc agaaagaatc tttttagcta cagcccctgc cgccactctg 2211241 acagttgttt cccttgctga agaacgctca agcacatttc tcatatcacg atgattatat 2211301 ttaattgcac cgtttaagtc agcgtgccca ggtctcggtc tggaaatctg gcgcttcatt 2211361 tccttttctt catcttctgt aatcggagcg gcgcccatga tttttgtcca atgcttccaa 2211421 tcgttatttt caactacgag agcaattggc gaaccgagtg tacgtgcatg gcgcaccccg 2211481 ctcataattt tggcctggtc tttttcgatc tgcatgcggc ggccgcggcc gtgtcctttt 2211541 tggcgtctgg caagctcaaa attgatatct tcctccgtta tgtaaagccc ggcaggtaca 2211601 ccctcaataa tggttgtcag ttgggggccg tgtgattctc cggctgttaa atatctcatg 2211661 acttcttctc ccttcatcgc attaacgctt ttaagtaaga ctactataac atatttttca 2211721 gcaaaaagtc agtctatctt ttttgataaa agaatgtatc ggctgggact aggccaaatt 2211781 tctcgggatt gaagatttgc tcggtgctgc cgacaaaaag aactccattc ttcttcaagc 2211841 tatgtgccat ttttaaatac agctcttcct tcgcgctttc tgtaaaataa ataaatacat 2211901 tgcggcacac gattaagtca aagtcttgtt cataacgatc cgccagcaaa ttgtgctttt 2211961 tgaatgtaat attctttttg atttccgttt tcacttcata acttctattt gcgttttgcg 2212021 taaaataacg atctttcaca gatagcggca cttcctgtaa agaccgctcc tgataaacgc 2212081 cttttttcgc tttttccaat gctttttcat caatatccgt cgctaaaatc tgatagcccg 2212141 gaagaccttt ttgctggtcc aaaagcatgg caagcgtgta tggctcctcc cccgttgagc 2212201 aggcggcact ccaaattttt aaaggcctag aggtcttgat taacggcaga attgcagtct 2212261 caagaacttc ccatctttta taattacgat aaaattctga aacattgatc gtcattctgt 2212321 ccaatgtttc atttaagaga gcttgatcct tttccaatgc cgcagcaaag tccttaaagc 2212381 tttggaaccc ctttttctca taaagtgacg ttagccttct cttcatttgt gcttctttat 2212441 atagtgttaa atcgactccg gttaattgtt tccatttcgt tgtaaatacg ctgtatgtat 2212501 ccatctctac tctcccagtc tcgctgtctt tttgtcctag tatagcttgt tttatcagga 2212561 aattgtattg tttcaataaa aaaatcagct tttcagctga ttttagatcg ttgggaaagg 2212621 cagaggtctg atgcacactg ccattcaacc ctttattcac tttaatgtaa acctttacaa 2212681 aacagaacaa aaaccggcgg cgttatatgt tgccggctct gttgcttatt ttcacaatga 2212741 ttaatagatc cagcctgcca taagctgctg atatgatact aattcttcat tcttaaagaa 2212801 aatgttaatc tcgcgttctg cactttcgag agaatcagag ccgtggatga tgttttttcc 2212861 gacaaacatg ccataatccc cacgaatcgt accaggtaaa gcttctttag ggtttgtttt 2212921 cccgatcagc tgtctcgtca cttcaatgac attttcgcct tcccacacca ttgcgaatac 2212981 aggtcctgaa gtaataaact caacgagctc tccgaagaaa ggcttacctt gatgttcggc 2213041 gtagtgtttc tcagccattt gttcagtcac tctcattaac ttggcgccag ctaattgtaa 2213101 gcccttacgt tcgaatctag ataaaatgtc cccaatgagc tgacgttgga caccgtctgg 2213161 tttcaccatg ataaaagtct tttccatcat attctccacc ccatcattat gtatgtatag 2213221 gctttcacac tgcacaccga aatcgtaaca tctttctgat aattaatcaa tccggggcgg 2213281 agaaatttct taatatctac aaaaattaaa attttctttt accgatatat tttgcgatgg 2213341 ctgcaagaga cgagcgtgcg cgccctcgag gaagcgtgtt taatttctga aaagctttct 2213401 gcagatacat ttcgcttact gccatagatg cttcaattgc atctgttttt ttgatttctt 2213461 caatgattgg ttcaagctgt tcctgcgttg tctcactgtt aatcaattta agctggtttt 2213521 ttaatgcagg atttttcagg gcatacagca ctggcaatgt gacgtttcct tgaagcaaat 2213581 ctcctcctac gggtttaccc agctcttcct cagttgaagt aaaatcaaga atatcatcaa 2213641 taatctgata agacatgccg acgtaatacc caaaccagta caatgcctta tgaatcttct 2213701 catcagctcc agacgcaatg gcaccaagct ggcagctgac cgcgatcaag agagctgttt 2213761 ttcttttgat acggcggaga tacgttctga gattttgttc catgttgtat ttgtctttga 2213821 tctgctcaat ttcccctaga caaacttcaa cgatcgtctg tgacaaaatc ctatgggctt 2213881 tcggttcgtt aattctcgtc atcatttcaa gagatcccgc aagcatataa tcgcctgtgt 2213941 acatcgcaat acgattgtcc cactttgctt tgattgtcgg ttttcctcgg cgaagctctg 2214001 catcatcaat gacatcatca tgaaccaaag atgccatgtg aatcatttcc agagtgacgg 2214061 cgacatattt aatcttatta atatcataat cgccaaacat gccagaaagc agcacgaaaa 2214121 caggccgaat acgtttccct ccggcctgca gcaggtgaag acctgcctcg cttaaaagcg 2214181 ggtaatcgga acgtacggtt tgttcaagtt ctctttcgat tacatcaata tcgtcattta 2214241 aaaaagagta ggccatttta aatttcatat cattcaccca aacatctgtg ttttcatttc 2214301 catccgatat gcgtggcagc gactccgcca gtaaacgaat gatatttaac atttttcagg 2214361 cccgcctctt caaacaggcc tgccagttcc ttcattccag ggaaatctct ggctgattct 2214421 tgaagccaag aatattcttt atagctcttc gcaaacagtt tcccgaaaaa cggcataata 2214481 tacttaaagt acataaagta agcctgtctg aatccgaaca tttccggctg ggacgtttcc 2214541 agacatacca cctgcccgcc cggcttcact acacgtctca tctctttcag tacagtcaag 2214601 taatcaggga cattgcggag tccgaagcca atggtgacat aatcaaatgt atcatcatca 2214661 aaaggaagct ccatcgcatt tccgtgcagc agttcaattt ggctgaatcc gccgtctttt 2214721 actttctgct cgccgacact cagcatattt tcactgaaat ccaagccctt gatctcgccg 2214781 cttttgcctg ccgcttttgc aagagcgatc gtccagtcag ccgttccgca gcagacatca 2214841 agtgcttttg cgccttcctt tacattcatg atgcgcatcg ttttgtcgcg ccatttttta 2214901 tgctgctgaa aactgatgac agagttcatt tggtcataat ttttatatat tttttcaaat 2214961 actccgtgta cgcgctgttc ttttgagtcc tgcataatgg tttacccttc ttccactttc 2215021 tgatgatagg tttgatcttg gctgattgtc ttcagacggt ttattaaaat gttctgaata 2215081 ggtgaattta gaggcagaag tgactcaatg ctgtttttcg cttttttaaa acaatcttct 2215141 aatatctctt cttttgtttt tcccagctgt ataaaactgc cgatcacatc cagaaatgca 2215201 tcatttccgt tcataagccg cttaaataca aaaaaatcac tcgacagctt tttccagcgc 2215261 gggaggttga agtgttccgc cacacgatgg aataaagctg attcaacgat gccgacactt 2215321 tcgaaaaaat cgttttcgtc cttgaaagaa cggtcataca gacgaatttt atgttcgttg 2215381 atttctttaa tggctgtagc aagcgtccga atcatgtaga tatccttcat ttcagatagt 2215441 aaagagtagt acagcccgct gaaataatcg cccgcgagaa cagtcaattg gcggtttttg 2215501 ttttcgtctc gttttatgac tctagctgtc gtcacttcat catgggtatc aagggcgctt 2215561 tgtacaagca tcgctgttac aatataattt tctctgtcgt tgttttttat gtcggcttct 2215621 tcaaataaag catgaaaaag aagaagctta tcctcatcaa ttttcggcgc agaaatatgc 2215681 ttcgctaaat aaggatgaga cagcttttgt tttaatttcg tgttcagatt ggctaaagtt 2215741 ccgtagatgt cttgcaaaaa tatcaccctt gtccccaaat tcacatttat ttcttaatct 2215801 atgtatgagt tttatctttt cattcgctta cgcaggtatc attatagcat aaaaaaaaga 2215861 aattggctgt atcctcccgc tgtttgcgag catttgcttt taacagcggg gacagccagc 2215921 ttattttttt tcgcttttca tttctccgta cgcggtttga atcagtgcct ctcctctgac 2215981 tttaatggca gaagtatgct ctgtaaactg agcgatgatc acttctccct tgtcgagttt 2216041 ttcggaatgg tgaaactttg tgtctgttcc tcttgtcagg ccgatcacat tcactccgtc 2216101 ctcaacggct ttaatgacga caaaatcact tgaatgcttt tggttcattt atagcaccct 2216161 ctatctttat tagtcctggc gtttaatatg ttccaatact tctgcacggg cagcggcatc 2216221 atctttaaaa acgcctctga ctgctgaagt cacagttttc gcacccggtt ttcttacacc 2216281 gcgcatcgtc atgcacatgt gttccgcttc aaccactacc attacgccat gcggatcaag 2216341 cgtttctacg atgctttctg caattgtaga agtgatgcgt tcctgaagct gcgggcgctt 2216401 tgcaacggct tcaacggcac gtgccagttt gctgagtcct gtgacctttc cgcctcgcgg 2216461 gatatatgca acatgtgctt ttccataaaa gggaacaagg tgatgctcac acatagaatg 2216521 aaacgctata tcttttacaa gaacaagctc ctcatggttt tcaccgaaga tagtctggaa 2216581 atgttctttt ggatcttcat tcaagccgga gaatacttcg gcatacatct ttgcgactct 2216641 tttcggagta tcaagaagcc cttctctatt cgggtcttct ccgatcgctt ctaaaatttg 2216701 acgaacagct tgttcgattt gctctttatt aacttctttc atgttctatg tcctccacca 2216761 atgaatacat ttaatttcga ttctagcaca tatgccccgc taaaagcaaa gtgaatgccc 2216821 tgtcaggaag cccatgctct tgaaatatga aaagcccctt agaaaggggc ttttctgtga 2216881 agaaataaag tgtatgtaag ctagatgcat acacgatcta tattcacaat tattttccgg 2216941 caactgcgtc tttaagcgct ttacctggtt tgaaagcagg tactttgctt gctggaattt 2217001 cgatttcttc acctgtttga ggattgcgtc ctttacgtgc agaacgttca cgcacctcga 2217061 agttaccaaa accgatcagt tggattttat caccgttttt aagtgcatct aagatcgtat 2217121 caaaaacaga gtcaactgct tttgtagcgt cttttttaga caattcgctt gcttctgcaa 2217181 ccgcattgat aagttctgtt ttgttcatgc ctttcacctc ctcccaaaag gatacattca 2217241 gttcgtttat tatcatttct tcacagttca gtctgattct aaacctgtct cagaaaaaaa 2217301 tgagagcaag taagagaaag acaattaaac ggctttttaa gaaaaactgc actctgagga 2217361 atgtttgtcc aacaaagtga agaatttctg tatgtagagt aacacatata aaaagccata 2217421 tcaagcattt taaagcgtca atcccttgct cgtcaaggat ttaaggtgat ttaccgaacg 2217481 aatattcctt tttttccttt tttcatccta ttccttgatc cttttccatt attaagagca 2217541 aagaaaaaag acctcccatt ctataaagag gtctaccggt attacaggat gatggcgatt 2217601 aagccgccag agccttcgtt tatgattctt tctaatgttt cttttaattt ataccgtgcg 2217661 ttttcaggca tcaatgacag ctttgcctga atcccttctc tcacaattga gctcagcgac 2217721 cttccgaaga tatcggaatt ccagatggag agcggatcat cctcaaagtc ctgcattaaa 2217781 tagcgtacaa gctcttcact ttgtttttcc gttccgataa tcggggcgaa ttcgctttcg 2217841 acatctactt tgatcatatg gatcgacgga gcgacagctt tcagcctcac accgaatcgc 2217901 gagccctgcc ttataatttc cggctcatcg agactcatat cagctaaagc aggcgctgca 2217961 atgccgtatc ccgtctgttt gaccattttt aaggcatcag acacttgatc atattctgtt 2218021 ttcgcatggg cgaagtcttg catgagctca agcagatggt ctcttcctct gatttcgacg 2218081 cccacaactt cttttaggat ttgatcatat agatgatcag gcgcgtacaa atcaatttct 2218141 gccacccctt ggcccagctc aattccggct aatccggcac tttcaatgaa ttcaaactcg 2218201 ctgaattggc cgacaaccct gtctacgtcc cggagccgtt taatatcctt aaccgtttcc 2218261 ttcacggact cctgatagct ttcacgcaac caatggtttt ctttcagcac cattacccag 2218321 cttgggagat tgacattcac ttctagcacc ggaaactcgt agagggcctc tctgagcaca 2218381 ctcagcacat ctgattcccg catgctctct acactcattg ccaataccgg gatatcatat 2218441 ttttcgctta aatcctggcg catggcttcc gtttccgggt gatacggcct gactgagttg 2218501 atgaccataa taaaaggttt gccaacctct ttcagctctt caatgactct ttcttcagcc 2218561 tctatatagt cacttctggc gatatctcca atggtgccgt ctgtcgtaat gacaactccg 2218621 atggtcgagt gttcttgaat gacttttcgt gtgccgattt cagcagcctc atgaaatggg 2218681 atcggttctt cgtaccaagg cgtattgatc atccgcggcc cgttttcatc ttcatatcct 2218741 ttagcgccgg gcactgtgta acctacacaa tctactaatc ttatattcac atcgagtccg 2218801 tctgacacat gaacagacat cgcctgattc ggaacaaatt taggctctgt agtcataatg 2218861 gttttgccgg ctgcgctctg cggcagttca tcctgcgctc gggcccggtc tgcttcgtta 2218921 ctgatattcg ggagcaccac aagctccata aattttttaa tgaacgtgga ttttcctgta 2218981 cggacagcac ctacgactcc taagtatata tcgcctcctg ttcgttcagc gatatccttg 2219041 aaaatatcga ccttttccaa gtgatcccct cccggacttc ctatcctttt caattttatt 2219101 aagctctttc aatcaaacac aggacactat atgtgtatga cgttgtccta tttgaatatg 2219161 acatctttag aaaatttctc atcctcaatc tattaatata aaaaaacctt tctccctatt 2219221 tgtatgcaag ggagaaaggt tcattccttt ttcatatcat tttctaaaaa aacaggttcc 2219281 tgtttgtcat ttaccgtata ttttacagaa aacgcgggga caaagggggt ttcatgccaa 2219341 atcatatcct ggatttcagt cccgggttta aacgtttttt tgcttttttt gaggcaagaa 2219401 gccagctcag tccggtaatc ggcatatatt tctccgtctc cgtcaatcat aagcggcaag 2219461 gaattccctg agattgggct tgtcactgta agagagctgc catccccaag cttcttctca 2219521 tcgagtgtaa ataaatcacg agatagcaca tccttgtaag gcggatattg atgctcctga 2219581 cgatacattt ggatgcgcaa tttcacatcg cgaatttttt ctgccatctt tagatcaatt 2219641 aatttaacag tcggatcgtt ctctacgtca acaagcacgt attgatagtc tcccccgctt 2219701 tcaaatgccg tacttggagg ttcagctatg tatcttggcg ctaaccggtt aaagtctatc 2219761 ggatattttt gatatagcgg tgtcgacata tctttggttt gaataggaag cagccctcca 2219821 tttgcctttt gaaattcatc aacagcagat tgaacctgct ttagctggtc ttgataagga 2219881 atggcatgca cactgctttt ccgttcattt ggatataaac atccggataa aaacacgact 2219941 gccgcaaaaa tgattgcgca cttcagttta cccatacagc acttcctttt acagctttat 2220001 tcattgacag ggccgctaaa aaccacgaca aacacaataa ttccagatat gagcatacac 2220061 atgtatgcga atgatgaaat cgcaatcttc aaaaaacggt tttggcactt aaagcggctt 2220121 aaatagatgg aagctacagc cagaaacatc agacccatgg accctagagc aaaccacatt 2220181 ttcatcaatg ccagattcaa tgacgtgcgc ctccccgata tgtaagatat aagcgttata 2220241 ttatatttta atatacagcg ccggaaaaga tcaaccagat tttccatcca ttgatagaac 2220301 aaaaaaactg aagcaaagag ggggaccttc gcttcagtca acttgactat attcacctgc 2220361 acgtttaaga aacactctct tggacttcga tgctatagta tgcgacttgg catacagatg 2220421 catcctctat tgcctaaatc ggcaaaatgt ttcaggagat cccaagactt gggtgttctt 2220481 ctgtttttcg ggctttcgtt caattaagat atgcgattca ccatttgatt gacactttta 2220541 cttcacttga ttttcaaacg tatttaccaa atcctccatc tcgtgggttt tccctctcgc 2220601 cattaaagat tcaacagcgg tttccacttt ttgtccgttg aataggacct gatggagagc 2220661 ttctgtaatc ggcattttaa catcatattt cttcgaaagc tgataagccg ctttcgtcgt 2220721 gcggacgcct tcgactacca ttcccatctc ttcaagaaca tcttcaagct tgtacccttt 2220781 tccgagcaaa ttgcccgcac gccagtttct ggaatgaaca cttgtgcacg tcacaatcag 2220841 atcgcctact cctgtcaatc cagagaacgt caagggattt ccgcccattt tcgttccgag 2220901 tctcgcgatt tcggcaagtc cgcgtgtaat caaagcagct ttggcattgt caccgtaccc 2220961 taaaccatct gtaattcctg cagcaagggc aataatattt tttaaagccc ctccgatttc 2221021 aactccgata atgtcaggat ttgtgtacac ccgaaaattg tgattaataa atagatcctg 2221081 cacctcttct gctgccctca tgctctttga agatgcagta acagttgtgg ggtgccgcag 2221141 ccctacttct tccgcatgac tcgggccgga aaggacaacg atatcttttc tgacatcact 2221201 cgggagctca atttccataa tttcagaaat gcgcagaagt gaatctggct caataccctt 2221261 gctgacatga acaaagactg cctttttcgt tataaaaggg acagcctgtc tcagcacttc 2221321 ccgaattgct tttgtcggga ccgcaacgat aatgacatct gcgtctgaaa cagcctcttt 2221381 catatctgtt gttcctttaa tggatgtaga cagcttaaca ttcggcaaat aatctttgtt 2221441 ttcatgcaac tcattaattt gatgaattaa atctgcacgg tgagcccaca cacacacttc 2221501 atttccatta tcagttagaa ctaaagccag tgctgttccc caactccccg ctccaagcat 2221561 tgtgactttt ttcatgtttg attcacacct ttttattttc tagctcttgc aaatattttg 2221621 attggtgtcc cctcaaaacc gaacgcgtct ctgattcggt tttctaaaaa ccgttcgtat 2221681 gaaaaatgca tcagttccgg atcgtttaca aacacaacga agcttggcgg ctttaccgac 2221741 acttgagtcg catagtaaat tttcaaacga gaaccgttat gagtcggtgt cggattcatt 2221801 gccacagcgt ccatgatgac atcatttaag acgtttgttt gaactcgaag tgaatgattt 2221861 tcactagctt tgataatcgc aggcatcaga gtatggatcc gttttttcgt taaggcagac 2221921 ataaatagga ttggcgcata atccagaaat tgaaaatgat cgcgaatatt ttcttcaaat 2221981 tctttcatcg tgctctcatc tttgtcaaca gcatcccatt tgtttacgac gatgacgacg 2222041 gccttgcccg cttcgtgtgc ataaccggcg atacgcttgt cctgttcaat aatgccttct 2222101 tcgccatcca gcacaaccgc cacgacttct gagcggtcaa tcgcttttag cgcccgcagt 2222161 acactatact tctcagtcgt ttcatagact ttcccttttt ttcgcatacc tgcagtatcg 2222221 acaatgacaa actcctgctg gttgtaagta aatgacgtat caacagcatc tcttgtcgtt 2222281 ccagccacgt tgctgacaat aacgcgttct tcgccgagca tcgcattcac aagtgaagac 2222341 tttccgacat ttggacgtcc gatcagacag aattgaataa cttcttcatt gtatttcgtt 2222401 tcaggaatgt ttttaaaatg ctctgcaacg gcatccagta aatcacccag tccgagtccg 2222461 tgtgttcccg aaattggata cggctcgcca aagcctagcg aataaaaatc ataaatattc 2222521 gctctcattt ctgtgttatc cagtttatta accgctaaaa caacaggctt ttttgtgcgg 2222581 tacaaaattt tcgccacttc ttcatcagca gctgtcacgc cttcacggcc gttcaccata 2222641 aaaataatca cgtccgcttc atccatggcg atttcagctt gctggcgaat ctgcgctaaa 2222701 aacggctcat caccgatatc aataccgccc gtatcaatca aattaaaatc ataattcagc 2222761 cattcagccg agctgtatat ccgatccctt gtcacgccag gggtatcttc tactattgaa 2222821 attctttctc ccgcaatccg gttaaagatt gtggattttc ctacatttgg tctcccgaca 2222881 atggctacga caggtttacc catagtaccc ttcctttcaa tccagccgct ttcattttta 2222941 cataaatttt caaccggtta ttaaaatcat ttcattcact tttatgaaaa gaaacccttc 2223001 agaggaaggg cttaactcat ttattatatc agtttttact gggatcacaa ctattcttaa 2223061 aaatgtttca cgatcaaata cacgtcatct ccgattctgt gagctattcc atcaaggatc 2223121 gcctcaagat ttttagcgaa aagctccatc tccttttggt cattgcaaaa aaagacaggt 2223181 gctccccctg caacccgatt tcgatttgtc gtgattacag acaaaatcac tttcgtaaga 2223241 gattcactca tcctatcacc ttatcctgat tcttgataaa ttcagtcggc attctaatcg 2223301 cattttccag ggttggaaca ttgctaataa tttgaacagc cgtttcggga tggtgaattt 2223361 gcgggagaac aaatactgcc actctcccat catttaaatc ccgttttgca attggtgtca 2223421 aagatggctc tcctgaatcc cgataaaccc cgagcacatt ggaaacatca aataaaatgg 2223481 cctgacgctg ccctaaattt gctatcgtcg ctgctgaatt aaagtttttc ggcgtcaaaa 2223541 taaagcccat gccatgcttt aaaatcagtt cctgtttctc tggaagcccg atattcatca 2223601 tataaatatt atcaacaaac agtcccggac cgtcaaagcg cggctttatg tactcgatat 2223661 ctacaatatc cttcaacaca ctgcccgaca taaacttcat ggccagtaaa aaacaaacga 2223721 cagccgctat gactgcagcc cagatggata aaaacacata cgcagaggtt gtcaaaagcg 2223781 ctgtaaagat cacaatataa tttctgcttt caaacgcaat ggcaatcccc tcaatatatg 2223841 tgcttcccct tgagacaagt tcatacgaat ccatttgcgt caatgtgttc cgctccatgt 2223901 ttcggacatc tctaaattgc gtcgctgcca atgttaaaaa tgtgatggcc gtaaattcct 2223961 cctgcaaaag cgccggcata ataattgcac ctaaaccagc cgctatcaac cccagtgcga 2224021 tgtgaatcac tttcccatga acataggtcg gatactggcg gtaatccgtt ttcagcatat 2224081 aaagccttgt cgcaattccg gcaatgaccc cagcaataat cggatagatg taatcactca 2224141 tgacattttg gtagctcctt tgtttgatct tttgcttttc tgaccaatct ggcttgcgag 2224201 gtgttcgtat ttagatatgc caaacagcaa tatcatcccc gcagaacacg cattcagcca 2224261 ttgaaagccg ccgacagcca tagccccggc caacttctgg atcacaaatg aatacaccag 2224321 ttcgccttgg cacatcccta ggacaaataa gacaagctgc ttctcaaaat tcctttcaac 2224381 agaagctgtt aaaagcacta ttaatataac agcagcccac tcaggtttta tgatgaacca 2224441 aaccgggtca tataatgcaa aaagataaac aaacgcatac gcggcaacaa gcgtcagata 2224501 gaccatgatg taacgaaaac gatacattcc caaatacccg gcatagacac atccgcaaac 2224561 gaaaaacatc aaatatgcag cattcaggga aaaatataaa gcgatgtcat gtatgcttag 2224621 aataatatta gttaaaataa agacagagac ggcaattcgt cttttcgtct tttcaaaaat 2224681 aaatgttgtc agaacccaca gaaaccacat tgaccaatag taataaaatt gttccatttt 2224741 acttcctcca tattcccagt atggagttca agcacatttt ttaaacaatc gatctcacat 2224801 taaggagtat gatcatggga aaagacagac aagagaaaaa actcaaagct tcaggcagag 2224861 tcgaatcaga tcgcgaccag tccattcact atgacggagc gacaagcctt gaacaaaacg 2224921 gaagattcaa aaagcgaaaa tcataataca aaaagcccaa accacatatg gttttgggct 2224981 tttatcattt atcgcacact atagcttgat gtattgaccc ctctctctgt gagccaatga 2225041 tgggtttcac ctttgatcac aaggggcgcc ttttgtaaat cggcaattgt tctggcaccc 2225101 agcacggtca taatcaactt taattcctca aggatcagct gaatctcctc aagcagtcct 2225161 tcctcaccgc tgtcagtcag cgcttttaaa aaatgccctg ccattccggt gcaagaggcc 2225221 cccagcgcaa ttgcctttgc cacgtcaagc gcatcttgca gaccgccaga ggcgatcatg 2225281 gtgcttgcag gaaactcaga gcggatttcc gccaaacttg cagctgtcga aatgccccac 2225341 gaattaaaaa aggagatttg ccgctgtctt cggagatttt cgattttcga gaaatttgtt 2225401 cccccgtaac cgccaatgtc aacagctgca gcaccagctt catacagctt tcctgctgat 2225461 gctttgctca taccgaagcc gacttctttc acaatgaccg gtacactgac ccggctgcaa 2225521 atttgttcaa tgcgtttcaa tgcgccgcta aagcttctgt ccccttcagg catcacaatt 2225581 tcctgaatca cattgaggtg gatctgcagt gcgtttgctc caatcatctc aacggcttcc 2225641 tttgcctgag cagccgttgc ctcgcttccc aggttggcaa aaatcagccc gtttgggttt 2225701 tcctttcgaa caatttcata ggaaagacgc tctgatggat cttttaatgc tgacatttgc 2225761 gatcccacag caaggggaat tccagcctga gaagccgctc gcgcaagcga tttattaatc 2225821 tcatatgtaa gttttccgcc gccgccagtc attgcattga taaaaatcgg cgaactgctt 2225881 gaaagttcgc cgatttttgt ggaaatatct acttgttcta atgcaagatc gggcagactg 2225941 acgtgaacaa acgtaatatc atcaagacct gtttcccgct tctggccgat ggacaaggca 2226001 tgattgatgt gttgtctttt tcgttctgct cgagtcacgt ttatcaccaa ttattttagt 2226061 ttattcagct tatctccgat cagatctcca agctggaagc cagtgcttgt ttcttccttc 2226121 gcttgatatt gacggtaatc ttcctggtca gctttaggcg tttcttcaag ttcacgcatg 2226181 cttaatgaaa tgcgctcctc attttcattc acatcaagaa ccttcacttt tacagtctgt 2226241 ccttcttcaa ggacttcatg cggcgtgccg atgtgtttat tggaaatttg agaaatatga 2226301 acgagacctt caacacctgg aaggatttca acaaaggcac cgaagcttac aagacgctgt 2226361 acagttcctt caagcacatc gccaggcttc actttttcgc cgatttggtt ccaaggtcca 2226421 ggcagtgtat ctttgatcga taaagaaata cgttcattat cacggtcaac cgataacact 2226481 ttcactttta cttcttgtcc ctcttcaaca acgtcagacg gcttctctac atgagagtgg 2226541 gaaagctgtg aaatgtgtac aagtccgtcg atgccgccaa tatcaacaaa cgcgccaaag 2226601 tcagtcaggc gctgtacttt gccatcaagt acacttccaa cttcaagaga ctgaagaagt 2226661 tcttgttttt tattcgcttg ttcactttca acaacagcac ggtgtgaaag gatcacgcgg 2226721 tttttatcac ggtcaagctc tacaacgagc agtgacagtg tttttccttt atagtcagtg 2226781 aagtcttcaa cgaaatgtgc ttcaacaagt gatgccggaa taaaaccgcg aacgccgata 2226841 tcaacgacaa ggccgccttt cacgacatct ttcacttcag cttcaaacac ttcttttgtt 2226901 tcaaattttt tctcaaggtc ttcccaagcg cggtctgcat caacagcacg tttagataaa 2226961 atcaaagcat cgtcttccac ttttgttact ttcaggtcaa gctcgtcgtc tactttaaca 2227021 acatccgatg ctttctctac atgaagactt gataattcac tgattggaat aataccggat 2227081 tgtttgacat tgataatttc tacatctaca tgtttgtctt ctacctttgt cacaatccct 2227141 ttaactacat ctccaacctc tggcacttga acatcaattt gattcatttc ctctgtcatt 2227201 tgaataacct ccttggtcca aacctacaca gcttaattaa aacggtttga aagctgaaca 2227261 tataacatgc ccgcttttag ccgaatatgt attaaagaat catccaaaaa agttttttga 2227321 atgatcaata aaaagtttta ttagtattaa cttctaataa aaggacaggt ttgtcaagca 2227381 ataacattct atcttcgttg aaaaattcaa aaaaagtggc atttgccatc ctcagcggga 2227441 cttttgctcc acagcctcga ggattttatc agctacctct tgaatggaaa gcgatgtcgt 2227501 gtcgatttca agagcgtctt ctgctttacg cagcggagat acttcgcgct ctgaatcaag 2227561 cttgtctctt cttgcaattt cctcaattaa tgtttcgtag ttgacatcaa agcctttttt 2227621 cacattttct tcataacggc gtttcgctct ctcttccaca gatgccaaaa gaaagatttt 2227681 tacttctgca tttggcagca catgcgtccc gatgtcacga ccatccatga cgacgccgcc 2227741 tttttcccca agctgctgct ggcgtttcac catttcttct ctgacacttc tgtgcttggc 2227801 cgcaattgaa acttggttgc tgatttcatc tgttctgatc gcctcagtta catcggtgcc 2227861 gtttacaaac actttttgtc catcttttgt tgtaatcagc tcaatgtctg tccgctttag 2227921 cagctcagcc agtttttctt catctgtcag atcaacgttt tcctgtaaag ccgcgtacgt 2227981 aatcgcccga tacatcgctc ctgtatcaat atatatgtac gattttttct cagccacaat 2228041 tttggcaacg gtgcttttcc ccgcagctgc cgggccgtcg attgcaatcg ataatttctt 2228101 ttccataatt cctctccttg ctcttttctc ctctaaggat tgtatcacga actttatgaa 2228161 aaagggtgaa aaattgatga ataattaatg tttgaaggtt tcaatcctat tgttttcctc 2228221 cattttatcc accccttcat attgaatcac ttttgatacg tatggttcaa tatgctgata 2228281 gtgaaaaaga aattggacac caagtaaaat gatggcctga atgaacaata atttgatcag 2228341 cagccgttca aatgttttca ttggagcacc tccattacaa atagtatgga agtgtttgcc 2228401 gatgtttatt ccattcgggc ctttcttctc ttatttaact ggcgcctgat gcagtattga 2228461 agcaaagcct gctggtcacc tgctgcaatt tctgaatact ctaaagtcat ttttcgtttt 2228521 tctgacttgg ggtcattaaa gattcgtctg acaactgctt ctgtttctat ttgacgtgtg 2228581 tgctcctctt caggaagacg gatgatcagg cgcaatgatt cccccgattg aaaagaaagg 2228641 ccatcagcta aaaccacggc gatgccgcct gcactgatgt tataggatag tgtgcggatc 2228701 tcttcttcat ttcccggctg aatttgcaca tctaataccg catcagttct tacatattgg 2228761 cggcgctgga ttcttttcat tttttcacgg ggaggcattt caagacagat catttgaagt 2228821 ttgtccttca ctttaccttt tatacggctt ataaagcgat aaggaacttc gtcttttccc 2228881 acaaactcta ccgttacttc catatcgtta tgtaaaatca cagttcgccc tgtaactaca 2228941 tcaacaggat acgcgatcaa aagttcattg ttttcgatgc tgaccgcctt gctttttgcc 2229001 tttttcaatt cattttcttc tatatattct aaaagtacat tttctccaat ctctatcatt 2229061 gacttcactc tttcgcattc aatatactca cgtttttatt aaagcacgta atgaaaaaaa 2229121 ggaaaagaca tttagtcctt tcctcctgtt tttataggtc tttatatata ggttctgcat 2229181 tttttagttt ttcaaccttt tcttccgatc cgtctttggc attgatatac attctgaatg 2229241 tgtcattttc aattgtccca agcatttcgt agcataacac ttcttgacct agttcatttg 2229301 taatcaaagc gagccttgtt tctctcactt gtacattttt atttaattta gactttgcct 2229361 ctgcttcagt aattgcaggc ttaggtatgg ttctttttct gtgagatgtg aggaagtctc 2229421 ttgctgaaaa gccgacaacc tcaccgtcat ccaaggccac tttcatacga attgcctcgg 2229481 ggtacatccg gactttattt tcaacaggaa catatgaaaa tacaccgatt ttatcatatt 2229541 gggcactttc atcaatttcc aaatcatctg tttcaaatcc gtttttcttt aaaaatgcaa 2229601 gcgctcggtt cgatccgtca tttaaactga ttttctgatc tttcacttct ctgttttgga 2229661 tcaagtatac cggatgcccg cccttcttcg taatatccat ataaatcact gctttatggt 2229721 ctgggtcttt catgctgatg ctatatacat cgcgatttgt tttttttccg ctctttacca 2229781 ctttaattga ataattgtca tctggggcaa agcgctcagc aatttgtttt gcttcctgtt 2229841 cggaaatttg ttttcccttc agatggctga agcctttctc ttcttttttc gtactggtga 2229901 aactcgggcc aagatcagtg ccagtggaga atgcaccaac atttttttcg actgttttaa 2229961 agctgttgat aatcgtatta tcactttgtt tttcgtcaga agccagagcc atttctacgt 2230021 ccatccagcg aaggtttttg ctcatgacaa ggtgctgaac atgacgcaat tcattttgta 2230081 tatcttcgga ctgctgatat agcttattta gtgatgtata ctcgttttta tcaagcggct 2230141 tttggtccaa atctctgact gacgttttat agctgaaatc gccgatcttt gataatagct 2230201 cttcagtttt attaaacggc attaatgtaa gcggcagctg actgacgctg ttatgagctt 2230261 ctgatgtaat cctccacaca tcgatcaatg caggcgacag tgatttttgg ctgttcatgg 2230321 caagtgttgt tccgatttta tcatgaagct gatccacctg ataggtaagc tcatgaaacg 2230381 cccgctgata gttattttca gcatgaagaa gaactgcgtc tttttcctgg tgttctttgt 2230441 atccccagta gcctgtaccg actattgcaa taccaagcac ggcgattaaa attcctctga 2230501 tcatttatca cacctctttt tatgctttct catatctgct actcacagaa aatgtgttta 2230561 ccgattcttt taatctgcgg acgcccccaa atccacggac ttgtagccgt atccggatta 2230621 aagtagtaaa gtgcttcctc tgatgggtcc cagccattga tggcatccag cactgcttct 2230681 cgtgccgttt cattcggctg catgtaaatt tgtccgtcgg ctactgctgt gaaggcaagc 2230741 ggctcaaaaa taacccccgc tactgaattt ggaaataacg ggctgttcaa acggtttaaa 2230801 atgactgctg caatagcaac ctgcccctcg tacggctcgc cccgggcttc gccataaacc 2230861 gcttgagcaa gcagcctgat atcgttgttg gaaaatccac caggcatgtt cgctgctacc 2230921 gcatcctgtt ttcttgcttt tgctggtgta ttgttttgct gtttattcgc attcgcttta 2230981 ggcttctgcg ttgttttttc cgcaggctgt ttctgccgtg cttctgcttg ttgtcttgcc 2231041 ttttgtgttg ctgcttttga tggtttcgtc tgatacttta gcggaatttt tccgtaatgc 2231101 gtgaatgtat tccctttatt gagctgttcc atgacatatt cacgatagta ttttgattta 2231161 catattaagg tttgctttgt tttagctcct acaaggccgt caacctcttt taacccgaat 2231221 tgatcctgaa aatttcgaac tgcccagtac gtcccccatc cataaacccc gtcaattttt 2231281 ccgttataat atccgttgta ttgaagacgc gcctgaagct cgaccacatc atcccctgtt 2231341 gcccctcttt gaatgacctg attcgaaaag gcagagatcg tttcagtatt aataaacgtc 2231401 gttattgtaa aggaaaaaag gatgagacat gccataatcg atcctttgga cttcatcttt 2231461 tcaagcctcc tactgcaaat ttttaagtgt aatcgtattt tctgtaacga ggttattttt 2231521 atacactctt tccttgttat ccctcagaac ataaaaactg cacacaaaaa agccgcacgg 2231581 ttgctgtgcg gcttctatac ttgcatcata ttaacggaac gggctttttt cgctttacgc 2231641 aaaccaaacc accataaaaa taccataaat ggaagcatat aataaatcca attgctaagc 2231701 gctgttagga taaaatcata tgatccatgc aaaagggatg ggacaactaa agaaagagta 2231761 agccacttta cacgcgcctt atcagcggaa aaacgggctt ttccaaggta aaatcccatt 2231821 ataacgccaa tcaaggcatg gcatgaaaca ggcagcagcg ccctgacaaa cgcatgctcc 2231881 acgccgtggc caattaaata aagaatattt tcgagggttg caaaaccgag tgatacactt 2231941 gcaccgtaca caatcccgtc ataatgctca tcaaagtggg cgtgcgggta aacactgatc 2232001 atcagtataa accattttaa tgattcctcc aaaaaccccg aagataaaaa agaaacgaaa 2232061 aagcttccgc ctcctacatt ctctttttca agtacatact ggataaacat gatgggaaat 2232121 acaagaacaa ccccgagaaa aaacgaccgt agcaccatat gtacaggttc attatcatac 2232181 tgatctttta aataaaaata acttaataac gcgatgccgg gggcaattcc tgcagagatg 2232241 attgcaaaca tcaggcaacc tctttccttt atattcctac atctatccta ccatgttgtt 2232301 taaaatttta catctgtctg cacttaaaaa aacaaaaaga gcatacgaat gcatcatatg 2232361 ctcctcatct ttaatggttt tctcttttgg cgatttccgc tgcgatatgc cccccgtgaa 2232421 acctgccgtt ttcaataaat atttcatttg cattgtttcc cgcagcaata acaccggcaa 2232481 taaagacacc ttcaacgttc gtttccatcg tttcttcgtt gaaaaatgga cgccctgttt 2232541 ctttatcaat ttcaacacca attttttcaa gaaattgatg atcgggatga tagcctgtca 2232601 tggcaaatac aaaatcattt ttaatggtaa tgagttcttt ctctccggag cgaaacacaa 2232661 cttcattctc ggtgattttt tcgacacaag ctccaaattc catacggatt gtaccgtttc 2232721 tgacgagagc ttcaaattcc ggcagaatcc acggcttaat gctcggagaa tactcattgc 2232781 ccctatataa aactgtgaca cgcgccccag atttcacgag ttcaagggcg gcgtccacgc 2232841 ttgaattttt cccgccgatg acaacaacat ctttatcaaa atacgggtgg ccttctttaa 2232901 aataatgaaa tactttcggc aaatcctcac cgggtacgcc catatagttt ggatgatcat 2232961 aatagcctgt ggcgatgata caatatggcg tcgtgtaggt ctcttttgac gtctcaataa 2233021 cgaatgtgtt attttgcgtt ttcgtcactt tacgcaccat ttcaaacgca ttaacacgga 2233081 tgtttttccg tttaacgact tcccggtaat acgataaagc ctgaattctg acaggcttcc 2233141 tgttctctgt aataaatgcc acatctccga tttcgagctt ttcacttgaa ctgaaaaagg 2233201 tttgatgcgt cgggtaattg taaatactgt taacgacatt gcctttttcg atgacgaggg 2233261 catcaatgcc aatttgtttt aggtgaatgg cagcagatag tccacaaggt cctccgccta 2233321 taataattgc tttttcttga atcatttctg tcaactcctg cgattggcat ttcacttcat 2233381 attttctatt tccgaataaa aaaatctcct attttatcat aggagatttt ttatttttat 2233441 gcaaatcatc aacttatatc cagcctctaa aacgcgaagc ttcagccatt ttgcgaacgc 2233501 cgaccatata tgcagcgagc ctcatgtcaa ttcttcggtt gttagccatt tcgtaaatat 2233561 tgttaaatga tttgaccatc attttttcta atttttcttc tacctcttct tcactccagt 2233621 agaagccttg gttattctga acccattcaa aataagaaac tgttacgcca ccggcacttg 2233681 ccagcacgtc tggtacaagc agaatgtccc ggtctgaaag aatttttgtt ccttcaagcg 2233741 ttgttggtcc gttcgctgct tcaacgacaa ttttagcccg gatattatgg gcattttctt 2233801 ctgtaatttg attttcaatc gcagcaggaa cgagaatatc acaatccagc tccagcagct 2233861 cttggttggt aatggtatcg ttgaaaagct ttgttacggt accgaagctg tcgcgtcggt 2233921 cgagtaaata atcgatatca aggccttccg gatcataaag tccgccatac gcatctgaga 2233981 tgccgacaac ttttgccccc gcatcatgca taaattttgc caaatagctt cccgcgtttc 2234041 cgaagccttg gacaacgaca cgcgcacctt taatatcgat gcctctcttc ttagccgctt 2234101 ctttaataca gatggtaaca ccttttgctg tcgcagattc tctcccgtga gatccgccaa 2234161 gcacaagcgg tttgcctgta ataaatccag gcgaattaaa ttcatcaatt cttgaatact 2234221 catccatcat ccaagccatg atttgtgagt ttgtaaatac atccggtgcc ggcacgtctt 2234281 ttgtcgggcc gacaatttgg ctgatcgctc tgacataccc tctgctcaga cgctccagct 2234341 ctctaaacga catatccctt ggatcacaaa caattccgcc tttaccaccg ccatatggaa 2234401 gatcaattat gccgcatttt aaactcatcc aaattgaaag cgccttcacc gccttcacct 2234461 ctttttctgt tacgttcggg tgaaaacgta tcccgccttt cgttggaccg acagagtcat 2234521 tgtgctgcgc acgatatcct gtgaaaatct ttactgaacc gtcgtccata cgaacaggta 2234581 tttttaccgt taataatctc atcggctctt ttaacaattc gtatacctct tcgggatatc 2234641 ccaatttttc cagagcctta tgtattacgg tttgggttga ttttaataca tcaagtttgt 2234701 cctcttctgt atgaccggtg tttcgatcgg ctgccatttg agttaacctc ctagaatctt 2234761 ctgtttctca catgctccct ttcagagaat agtatacacc ttcatatgat ctgtgcatag 2234821 aataaacgtt atgtttttcc atgtttttta acgaaaaaaa actgctgaaa tcagcagttt 2234881 tccgttgcat tcttatgaaa aatgagtttg tatcgtttct acggcattac cgtccataat 2234941 gagcttacca tactcttgca ggcgataaat cgttaaagtt gtcggattgc cgtattcagc 2235001 cagaaccgcc acaacccctt cagccgtatg tgaccctaga tcttcaaggc ttaaaaagta 2235061 ctgcccgtca tagtggtaga cagttccccc tgtgataccg attcgctgta agctttctga 2235121 aagctgaatg atatcttcaa aggaatggaa ttgatatatg atgtccgcgc tttcatcaag 2235181 cttgacttgc atttcgatgt aatcatcatc atactcatcg tcttctgaat cggcgtcttg 2235241 gttctttgtt acaatcacga ccatcccttg tgcttggaga gaatacactt ccactgcaat 2235301 cggtccattc gcttcaaagc cgagctctgt atttgcttca ttcatcatat ctttaaataa 2235361 ctggtggact ttaaatgagt ccttccagag gtcttctttt gtcaatcccc ggtctgtcaa 2235421 atcatcgagg gttaaaaaga ttttgatctt attataattc agacgctcaa gccgcataac 2235481 gttccctcct gcctctactt gcacacaaat catataacac attatatgag atgatgagtc 2235541 ataggttctt aattgttatc agtttacact gagttcacta gtaagacaag cacaatgcag 2235601 tttttattgc catacggatt tttgcttttt agaagttatt ctggcccgca aagagtcaca 2235661 atgtgagttt caggctcagc acctaaacga agaggcactt ttgtcgtgcc gtagccgttg 2235721 ctgatcagat atgccgcgtt tttaacaata cctgttttcc ccagttcata aggaccgaat 2235781 tttccaaacc tgatctggcc tccatgggta tgtccgctga gtatcacatc aataccgtca 2235841 tcttcattga tttgttcatg aatctccgga ttatggcaaa ccagaatatt cagctggctt 2235901 tcatcaagtt ctttgatggc ttcctcataa tgatccatct ccatcctgat atcatcaacc 2235961 cccgcaatcg caatcgtatg cccattgtat gaaaacggga ctgactcatt tctcagagtg 2236021 atgacgccgt gcgctttaaa tatggaatac agcttatgct gcctgacttc ataatcatta 2236081 ttcccccaca caaacacgat agggaccccg aaatgtacga gccttttgat gttttcctcg 2236141 attctcgcac tgggcacccc gccctcagct aaatcaccgc cgattataac caagtggggg 2236201 gcatggcttc gcgctttttc taaaaggtct tgatcgatga gacgtttgtg aatgtctgaa 2236261 ataaaaaaga ttgtcagagg cggcttgccc ttcatctttg ataaaggaaa cgtatgtgtc 2236321 ttcaaatgat tgccttttgc tgttgcatac atttttgccg tcattgccgc tgccgcaaca 2236381 gttagtacac cggcaatttt cactgatagc ttcataaaaa actctccatt ctttttagaa 2236441 cttatcaata agacggacaa taaaaaaaga cgtttctatc gtttgagaaa acgccccatt 2236501 ttatttactt tcaaaatata gattaatgtc atatttgtgc ttcatcatat gaaaaacaga 2236561 ctctctcgcc ttccatttat cgggctgcgg ccagagatca gtgcttttct gaataatttc 2236621 acatctcagt ttatggaaat cagtctcgga tttttcttcc tttttcttga aataatatga 2236681 agtgcagtag gcaaaagcgg ttgccagcat ccaaaataaa taaaaggtat ggctaagtat 2236741 ttcttgaagt ataagctgag gctccgggct tttgatcatg atcataacac ataataagcc 2236801 taggcagata agtgaagccc atcgccatct gcggcattgt gctgcataat tttcgaattt 2236861 ttgttttcgt tttaccagcg cttggagcat ctgtttggtc ggcgcgtctg taaactgatc 2236921 cagctgattc cataaggatt ccatacgctt cacaccttgt ccattttcat tgctacaata 2236981 tatgaacgta aaataaaaat aataccctat tcatccatta aagggatgtc caaaacttgt 2237041 ccggtgtaaa catcatttcc attcagatga ttatatgctc gaattttttc ttctcctgtc 2237101 cggcttttat aatacttcat ggaaatgcgg tatagcgttt ctttcttttg gacggtgtgc 2237161 ttgacaacgc gattcggcac attttgaact ggctcagctg gctgttcttg ctgttgtact 2237221 gttgattggg aagaggaagc agccgcggcg gttgcttcct ccttatttgg cgagtcttct 2237281 ttttccgcta cagcagtctg tttcttatca gcagctgttt gctcttttgg cttggaatct 2237341 tctggctctt tttttgactc cttctgcagt gcggtttctt tagtgtctgc ggtatcgttt 2237401 ttatcctctg atttcgggac aacctcatat ttgctttggc tgctgtcaat aaaaacatct 2237461 tcataatcgt catgattatc cgggtggctc tttagataaa ataaggtgac taaaacgata 2237521 accggcacaa atacaaatat tactgcgagt actgtgaata atggcgtttt tgttttgcct 2237581 tgcttttttt tctgttctct ttgatttttt acagattgtc ttgtcggaag gctttctcca 2237641 tcatcgacat aatcgtccgc caatgcggcg ttttgatctt cataaagatt ctgggctttt 2237701 cttctctcta ctctcgacat gttcgtcatg tttatccctc ctcacatgtt caaaacgaat 2237761 ctgacaggca aacacggcat caatgataaa atgcgccgtc atcggaacaa ataagttgcc 2237821 ggtccattca tacatcagac cgagcaaaaa gctgattgct gtcaccataa taaataacag 2237881 ccattttgac aaataccgaa agtgcagagc ggcaaatata aggctggccg tccataaacc 2237941 gatatgagtc tgcagcactc ctctgaataa catttcttcc gcgaaagcaa tcagaagcgt 2238001 taaaaatata atatgaggga ttgacctctt actgaatatt tttttattga ttccgccgtc 2238061 atcatataaa tgagacggaa accatttcat tactgccata tcggctaaaa taacaataac 2238121 agctatagaa acaccatacc agatgattcg catatcgcga atgtcccaga gctttaatac 2238181 gtcccgtaca tcctcaaaaa agaacagtcc tgctgcagca gcggcaaaga tgatgagtag 2238241 ctgcgtcaaa tataactgct tcagcatatc atggtcagtc atatgctgaa tataatcttt 2238301 ttgctgtttc agttcagctc acctacagtc tgcaagctga atatccggtg caattccgaa 2238361 ctccagctgt ctaatggcgc cattttactc cgttcccctt tttgttcata caaggataaa 2238421 tcaaaaccgc aatgtgaaca gcacgggagg tttccgtcat caggctcgta tgattcatca 2238481 aagtaggtta acagtgcctg ccttaaacag ccgtcacgct gaagcaaaaa tgatacacgg 2238541 tgcatttttt ccagcttcag ctccatgcga tatgaaattt ctttcttcat cagttcaact 2238601 gatgtttttc cctgcataaa gagatgaatc atcatacggg cctgtgtctc tccgacgcca 2238661 tactgaagta atacgtcacg cagccttctc tcatcccgct cctccgtctt ctctagcaca 2238721 cggattacgt cggcgatttc ttcagctgtg acactctcca tctggataat ttgttcctgc 2238781 aattcaaaat cccctggcgc ccgcagcaaa atgctgacac tcggctttcc gtcgcgtccc 2238841 gctctgccga tttcctgcat aaaagcttct gccgtctgcg ggagatgaaa atgaatcaca 2238901 tatctgatat caggtttatc gacacccatt ccaaacgcat tcgtacaaca tatcacatca 2238961 agctggttat gaataaactg ctgctgaatt aaaatcctgt cccctgactc caaaccgcca 2239021 tggtaaaagt cggctctgct gctcgttttg cttttaattt cacccgctaa ttccttagcc 2239081 catttccgtg ttggacaata aacaattccc ggaccttgca ggttttcaac cagctgaatg 2239141 accctatcta ttttttcggc agtatccgcc gcattttcaa ccctcagtgc gatgtttggg 2239201 cggttgactg agttgagatg gcgtacagca tgctgcagct ccagcaggtt catgacatct 2239261 tgcagcgttt cctttgtagc cgtggcggtc aatgccagaa cgggtgggtg tccaagtttt 2239321 tttctcagct gtccgagctt tgaataatca ggcctgaagt cgtgtcccca ttcagaaata 2239381 caatgcgctt cgtcaataac aaataggcta atcggaacgc ttttcaattt ttccaataca 2239441 tatggagact gtaaagcttc aggagacaag tacaaaaatt tatatcgatg aatatgttct 2239501 aaaacaaatt gtctttcctg cctgttaagc atgctgttca aagctgcagc acgcttttcc 2239561 ccccgggctt tgagctgctg cacctgatcc tccattaaag aaagcagtgg agaaacgatt 2239621 aataccatgc catcaagcat ataaccaggc agctggtagc aaagcgattt ccctccccca 2239681 gtcgggagca ttgcaatggt atccttcccg ctgagtatgc tttcaataat gtcctgctgc 2239741 ccttttttaa aggaagtaaa accaaaaaac tgatataacg tttgctgtaa tttagtcata 2239801 ttgctgcacc tgctttgtca atgccagtct gatttgaaag tagctgaacc gctgttccag 2239861 cccgtcgcga atttgtttga ttttattcgt ccgcatccgt ttggcaaact ctgcgatttg 2239921 aagctggtct tctgctgata catagtcatt aatcataaac gcaggctcat ggagagaaat 2239981 ctcgacaatg tggtcttcaa tcgtcgctgt tttcagcttt ctgatttcag caattcgctg 2240041 tatcggaaac ccttgtttga ccatctgcca tgttttcctc gtcgactctg tcagggcatt 2240101 atctaagtgc acatcagaaa ggagatcctt taacaaagca tcttcacact ccggaagaga 2240161 atgaataaaa taatgtaccg aagcccaaaa catgatatag acataccatt cgtcttcttt 2240221 cagcgtatca gcaagctgcc tgctcgtata accgatccga tggtgcgagg ttaaggagta 2240281 gacaaaaatt tgcgctgctt tgttttcaat ctttttcaaa tgcgcctcaa gcatggcaaa 2240341 aaggcttttt gccatctcta tatgatccgt atgccgggac aggtatttct ttacccagtg 2240401 aagtgtctta tgatcctttg tgacagggat atactgcctg ctcccttgct gtttatggga 2240461 taggacctgc acaagcagcg aaagcctttt ccaaagcacg ccggcagcct gctgataatg 2240521 agcgccgtga caatgaacgg gccaaggccg ctcgctaagg gcatgtctca aaactgctgc 2240581 gccgctggct gtcactttgt atgtatctga ttcagacatt ggcgcgagat atgaatgctt 2240641 ttcaagcttg tcaagcgacg cagaaatatc gcttctcgaa cattttgccg ccattccaaa 2240701 gtattttgca gtctgaaata agccggcatc ttgaatggtc tgtgacgatc tcttgccttt 2240761 gaataggtga aaaacagcgc ttcccgaccg ttccccgttt attttgcaaa gacaatcgag 2240821 aaccataata tcgaagtaat ttaatgacaa cctatccacc tacattcttc ctgacaaaaa 2240881 tcgttgattt gctcttttta ttttaacaga tttcaaacag aaatcgacgt ttaaagtcat 2240941 cattaagggg gatgttatgt agataacccc ttatgtgata agcattctca atcatttttc 2241001 tgttgaaatg tggcagcaac atcattacaa taagtaagag gaataggtgt taaattgatt 2241061 aaatataaag attgatccat ttgttccacc aagaacaatc tgggaggttt tattcatggc 2241121 aaagtacaca atcgtagaca aagatacatg tattgcatgc ggcgcttgcg gagctgctgc 2241181 accagacatt tacgattacg atgatgaagg catcgcgttc gtaacgcttg atgaaaacaa 2241241 aggtgttgtc gaagttcctg aggtactgga agaagatatg attgacgcat ttgaaggatg 2241301 ccctactgat tccatcaaag tggcggatga gccatttgaa ggcgacccgc ttaaatttga 2241361 atagaagtaa ctaaaaaaag ctcccgaacg ggagcttttt tatttaatgg atatgtgcac 2241421 ttcgctgctg ctcaatccat ggcttaagct tgataaaaat tagtgagaat acaaccgtaa 2241481 ttacaatacc ttttatcatg ttaaacggca ggatacctgc gacgactgct gtttttagcg 2241541 cgctgtcgga taatgccggt gaatgtaaaa accacgtgta tgccggaaga atcagaacat 2241601 aatttaaaat actcattaaa atggtcatcg ctgcagttcc caaaagcagg ctgacagcca 2241661 agccctttgc tgagttgagt tttttaaata agaaagcagt cggtaatata aagagtgttc 2241721 ctgcaataaa attcgcaact tgccctacag gaactccggc catgcttccc tgaatgatat 2241781 actgaagaac attttttatc gcttctacgg caatacccgc caaaggtccg taaatcagaa 2241841 tggcaataat tgcgggaacg tcgctaaaat cgatttttaa ataatccgga agacccggaa 2241901 acgggaaatt taacagcatc aaaacaaatg caatgctgct cagcatgctg accacaacta 2241961 atttttttac tttcacttca ttctctcctt ttcgatcaca tcttactcga aaacggaaag 2242021 gttcttttcc agccaataaa aaaaccgctt catatataaa agcggggttt cgaaaattag 2242081 gctaggcaaa gaaacgtttg aaaaattcaa tttcaaaacg cttatgaacc tccatcttct 2242141 cccatccaga ctgtactgtc ggctccggaa tctcaccgaa tcctgctgta aagacagctc 2242201 gcgggcttag agccattggc tcatcaccgc cggtagggaa tttcaccctg ccccgaagat 2242261 tgatcatatg aaatttaatt acattataaa cgataactgg ttggctgtat agagaattgc 2242321 ttcaaattaa atatattacc tgcaagctgt cagatcattg atttattagg ctttactttt 2242381 atcctttact gcgtcaatac acgttgacac tcttttgaga atatgttaaa ttatcagata 2242441 tttagtttgt caatttagga ggaaatctaa cgatgtttcg agtattggtc tcagacaaaa 2242501 tgagcaacga cggtttacag ccacttattg aatcagactt tattgaaatc gttcaaaaaa 2242561 acgtagcaga tgcagaagat gaattacata cttttgatgc tcttttggtg cgaagcgcga 2242621 caaaagtaac agaagacctt ttcaacaaaa tgacttcttt aaaaattgtc ggaagagccg 2242681 gtgtcggtgt cgataatatc gatattgatg aggctacgaa acacggggta atcgtgatca 2242741 atgctccgaa cggcaacacc atttcgacag ctgagcatac atttgcaatg atctcttctt 2242801 taatgagaca cattccgcag gctaatatct cagtgaaatc cagagagtgg aaccgcacag 2242861 cttatgtcgg ttcagagctt tatggaaaaa cgcttggtat tgtaggatta ggccgaatcg 2242921 gaagtgaaat tgcacagcgt gcgagagcgt tcggtatgac tgtgcacgtt tttgatcctt 2242981 tcttaacgga agaaagagcg aaaaaaatcg gcgtaaacag ccgtacattt gaagaagtgc 2243041 ttgaaagtgc ggatatcatt accgttcaca cgcctttaac aaaagaaaca aaaggcttat 2243101 tgaataaaga aacgattgca aaaacgaaaa aaggcgttcg cttaattaac tgtgcgcgag 2243161 gcggaattat cgatgaagca gcacttctcg aagctttgga aaacgggcat gttgcgggag 2243221 cagcgcttga cgttttcgaa gtcgaaccgc cagttgacaa caaacttgtt gatcatccat 2243281 tagtcattgc cactcctcac ttgggagcat caacgaaaga agcacagctc aatgtcgccg 2243341 cccaagtgtc agaagaagtt ctgcagttcg caaaaggcct gcctgtcatg tcagctatca 2243401 acctgcctgc catgacaaaa gatgaatttg ctaaaattaa gccttaccat caaattgcag 2243461 gaaaaattgg cagccttgta tcacagtgca tgaaagaacc agtacaggat gttgccattc 2243521 aatatgaagg cacaattgct aaacttgaaa catcgttcat tacaaaagcc cttctgtcag 2243581 gctttttaaa accgcgcgta gactctactg ttaatgaggt caatgccggg ggtgtcgcaa 2243641 aagaacgcgg cattagcttc agtgaaaaaa tttcctcttc tgaatctgga tacgataact 2243701 gcatcagcgt aaaagtgaca ggagaccgca gcacctttac tgtaacggct acgtatattc 2243761 ctcatttcgg agaacgaatt gtcgagatca atggatttaa tattgatttt tatccgactg 2243821 gtcacttggt gtatatccag catcaagata caacaggtgt catcggccga gtaggacgta 2243881 ttctcggaga taatgatatt aacattgcaa ctatgcaggt tggccgtaag gaaaaaggcg 2243941 gagaagccat catgatgctt tcctttgaca gacatctgga agataaaatt gtgaaagaac 2244001 taacaaatgt ccctgatatt gtgtctgtga agctcattga tctgccataa ttaaaaaaac 2244061 tcaagctata tagcttgagt ttttttattg ttctatcccc gtgtgttttt atgcaaaata 2244121 tctaagacac tccttagctc agaaacagga atttggcctg gtgcggacgc ctcttctcca 2244181 gctccaaaag tacaagccga tccaaaaacc tcaccgctca gcctgctgat gagccctgtt 2244241 gcagccattg acattgtaat aatggggcgg tctgcatata ttgttttcat tgtatacgtc 2244301 gcatcaagca gtgttaggag atctccagta tcattcggca tgacagccat ttttggaata 2244361 tgcgcgccta agtcctgcat ttttcgaagt ctggaaataa tttcatcttt tacaggtgtt 2244421 ttttcaaagt cgtgatttga catcaccaca tagacgttgt tttcttccgc cagcgatact 2244481 aacgctttta catttgcatc tcctgaaaat aattcgatgt ctatcagatc gatgtctttt 2244541 gtttggattg ccgattccag caaagcaaga taggagcttt cgtccatctc catgctcccg 2244601 ccctctttgt gggttctgaa tgtaaataga aatagcttgt cttctaaaga tttacgaagc 2244661 ttagaaatga gctttgtgac cgcttctctg tcattcgctt tttcaaatac gtcgactctc 2244721 cattcaacaa tgtccggatt cagtaatttt actgcctctg cttcattcag aatttgtttt 2244781 tccgtctttc ccatcagcgg aatgatgatt ttcggcatcc cttccccgat ggaaactcct 2244841 ttaatcgtta acacgttcac tcgtctcaaa tcctttcaat ctttaccttg ttttattata 2244901 cacgtacaac ttttttttga aaatttctat tatatgaata gcaactaaaa aagagcctta 2244961 aagggctctt tttagtttaa ggaaatcgga tttggagcag ctggcaccgg aattgcatct 2245021 gatatgtcat atttgccgat ttttttcgtt ctggtttccg taaaggtcac ttctgtgaag 2245081 ccaaactctt ttgcagtcaa aagtagtccc tcaatcatta aaataccggc aatagaatca 2245141 tcaacttctg actcctttga aaagcggata tataagtgtt tctgtttctt cgttacagat 2245201 tggacagcac ccgcttgaat aagaggtgtc gtatcttctt ggctgctcga ttccatttcc 2245261 ttaatcgctt cttttactgt atcaaaagaa tgatttgacg gaacgagaaa gtcttgtcct 2245321 tgtttatttt ggtacaagta gtaggatcgt tttgactgtt tgggaatcga aatttccgta 2245381 aaagtgccat atgagccaat ccgaacccca gtctcatttt gatccgataa aaatttgact 2245441 ttttcataag gactccattt taaggattct ttaagcaatt tttttaacag tgtatcatct 2245501 tttatagaaa atgccgtagc tggctgatgg actcgtatac ttaattcctt ctgctttggt 2245561 ttttccttta tttctacttc atctatgaag gttggaattg taatggcatg atcaaggatg 2245621 cccaattcac tactttcaaa cagcatatcc tggatcgttt ggtctgcatt tgttttttga 2245681 atgctgacgg gtatgattgc agatgtatcg gcatcagcaa ccgctacagt gatgtaattg 2245741 tcttgttcct tttcaggaac gacaaacgat gtctgatcca aggacgatgc agcttttggg 2245801 ctgtcttctg tctcagtttt cgttactgcg ttctcttggg acgcttcttt ttgttgaggc 2245861 tgtgcctgat caaagaaatg aggagaaata atgaaggcga tataaaccgc aattgcagcg 2245921 gcacacgcgg ggccaatcca cctgacagcg ggcttatttt tacgctttgc catcgtcagc 2245981 cgcttgtaaa tatcctgagg cgaacgatgg tctttaactg ccggaagttg acttaacaac 2246041 tcctttatct gttcttcgtt ccattctgac ttcatcatcc attagctcct ccctcaaaag 2246101 ctccatatgt ttccgaagta ctttgagccc tctgtgttgg gtcgttttta ctttgctttc 2246161 cgagaagcgc agagccttgg ctgtttcctg tattgaatat ccctgaataa accgcaagat 2246221 aatcacagct ctttgatcga ttgtacattg atcaagcgca gcataaattt cccggacatt 2246281 ttcatgttga accgcaagtt cgtccggcag caattgctga tccctgacat cctgtgtatc 2246341 ccagtcaaat gtaccgagta tacgctgtct gattgtttgc tgtttacgga accagtctat 2246401 cgcaacatgg cgtgcgatag acaaaagcca tgttttttca ctgcttcttc cttcaaacgt 2246461 atgataagaa tttaataccc ggatataaac ctcttgaaga aggtcttctg tctggttttt 2246521 atcctttacc atataaaata aaaattggta caaatcttga tgatatgtat catataataa 2246581 ttgaaaggtt tcttccattt gaaacccctc cgttcacttt tttgtcgtat gaatagcttg 2246641 aaaagttaca ttacaactat attacgagta actggaattt ggaagggaat ttatattaac 2246701 atatccttaa attttattaa tgttggctat taaaaaaaca cccgctcagt cagcgggtgt 2246761 ttcttatgga acaagattct tcggcaaatt cagactcgat tttaccgttt tgtcggaata 2246821 taaaaagaaa atgttgttcc tttatctatt cggctgtgca cagtaattga tccgttgtgg 2246881 gcttccacga tatttttaac gatagccagc cctaacccgg ttcctgctct gccccttgtc 2246941 cgcgctttat ctgccttata aaaccgctca aagataaatg gcagatcttc ttccggtatg 2247001 ccagacccgg agtctttgat atcaattttc aatccatcct tcacagaatg gactgaaatg 2247061 gagacactgc cgccggctga agtatgccgc agcgcgttat caatcaaatt ggtaaatacc 2247121 tgctccatct tgtcttcatc aaacataaat tcctcttctg tgagagaaat gtcatgatct 2247181 aaagcaatat ttttttcttt cgcaacaccg gaaaacttcc gaatgatctt ttctaaaaac 2247241 tcattcacat tgattttttc ataatgtaag cctgtatggc ctgattccat tcgggctaaa 2247301 tcaagcaaat cattaactaa acggcccatt cggagcgatt cgtcataaat gatttgggca 2247361 atttctttcc ggtcttcttc agagcttgca atgtcatcga caattgcttc actgtatccc 2247421 tgaagcatgg agatcggtgt tctcagctca tgactgacat ttgcgataaa gtcctcccgc 2247481 agcttatcaa ggcggcgttc ttctgtcatg tcacgcagta cggcaaccgc tcctctgacg 2247541 tgcgattccg cataaagcgg cgacatcaaa agcacccatg atctgccttg aagcgtcatc 2247601 tcaatcattt gttctttttc agtgctgaca gcgttttgaa acagctcttt tgcttcaggc 2247661 ggaagattgt cgccttcttt gatattcatg ttctgttcat aataccaagc ctgaagaaaa 2247721 cgttcagccg gcgggttggt cacaagaatc gtaccgtcaa tattaatggt aataaccccg 2247781 tcagccatac tgctcaaaat gttagaaagc tgctcttttt cttgattgag cgcattgata 2247841 tgaaagttaa gctgccggcc catttgatta aaagcggtcg ccagttcacc gatttcatcc 2247901 tgagttaaaa tcgggatttt tgtatcgaac ttgcccttcg ccaaatcctg cgcgccttct 2247961 ctcatttttc ggagagggta cgtgaccctg cttgataaaa agaatgcgaa aaatgtggtc 2248021 agcacaatcg caattccagc ggcaagaaaa atatagcggg tcgtatgttt tgttgtatct 2248081 ttaacggcaa gcaaagactg ggataaaaag accatgcctt tctttccgtc tttttcatac 2248141 gggacaccta caatcaggcg ttcattatcc gtgtctgtat cgctcagtcc cgtccgtttg 2248201 cttacttttt tatggtcttt gagagcttta tttaagtctt tgtcatgctg tatttgctca 2248261 accgtaatag acgacaggcg atttttatca ttcggagaat accagtggtt cttctcatcc 2248321 tggatgatgg caatgcttgt taagttatca gcgagttccc aagtgattga ccttgccagt 2248381 gcctggtcct cgtgattttc taggatgaca gcaactttat tcgcaagctg tgttaaatca 2248441 ttctcagctt cttccacatg gtagttttca ataaactcca gcaaaagaac cgttaaaatg 2248501 aacaatacga tcaagacgag tgaaaggatc gtaaaccaca gcttgcctac tacgcttttc 2248561 caaaatttca ttcagcgccg acctcaaatt tataacctac accccatacg gtgacaattt 2248621 ttttcgcagc ttccggagat accttgttca gcttctctct caagcgtttg acgtgagtgt 2248681 ccactgtccg taaatcacca aaaaactcat attgccacac ttctttcaga agcttttccc 2248741 gatcatacac cttgtcaggc gttttcgcta agaaatatag aagctcatac tcttttggcg 2248801 tcaggctcac ttctgttcca tcagctgtta cgcggtgagc atcatggtct attgacagat 2248861 gtgaaaacac gagcacattt ttcgtcggtg tattggcatt gaaataagag gtttgggatg 2248921 ctcttctcaa aagggccttt acacgcagca cgacttctct cgggctgaac ggcttaacaa 2248981 tataatcatc tgttcccgct tcaaacccct gcacccggtt tgcttcttct ccttttgcgg 2249041 tcagcataat aatgggtgtc gctttttttt cacgaatttg ccggcacact tcaattccat 2249101 cagtccccgg catcatcaga tcaagcaaaa ttaagtcata attggcttca agccctttgg 2249161 caatggcttc atcaccattt tcagcttcat ctatagcata attttcacgt tcaagataca 2249221 ttcttaaaag gcggcgaatt ctggcttcgt catcaactac taatattttt gtttcgttcg 2249281 tttggtccat gttttccccc tgctttcctt ctgttacttt cattttatca aatcgtgaga 2249341 aagtttgaga actgtgtcgc tttcaaagga ctatgcataa gaatgaagtc cggcaagcac 2249401 aagatttacg aatattaaat taaacataat aatagcaaaa ccgattacgg ccagccatgc 2249461 tgacttctca ccgtgccagc ctcttgacag tcttaaatgc aagtaagcgg catagaacaa 2249521 aaatgtgatc agcgcccata cttccttagg gtcccagccc caaaatctgg tccacgcgag 2249581 ctgagcccaa atcattgcaa agatcagcgc gccgagtgta aagatcggaa atccgattga 2249641 tacggccctg tacccaacct catccaccag atcaagattg acgtttttca ccagcggatg 2249701 taatagagcg ctgattcttt ttctgatgat cagacggaga gccccataca acacaagacc 2249761 tgctccaaat gaccaaatga cagtgttcac ttttctgcct gagaaaagcg cgggaagatc 2249821 aacaagcggt tccattcttc cttcggtcaa aagctctccc tgatgcggac cgacaagcgc 2249881 gggcatttcg tacaccatca cgcttttttc tttacttttg tccacccagt taaactccgc 2249941 ttcatagcct gcaagacgaa atgccgatgt gattgcaata aaggcgacgg ttgtgaccag 2250001 gataaacata atcgcttcaa gccagaaggt ctttttgctt ggctttgtct ggtctacatg 2250061 cttcaaaaga aagatgacac cagcgacaaa gctgatggca agtatagctt gcccaagcgc 2250121 ggccgttgtt acgtgaatat acagccagtt actttggagc gaaggaatta aaggcgagat 2250181 atctgtcgga aacatgctgg cgtaggcaat cagcaataaa gcaattgaca gcgtaaacag 2250241 gcctaatgaa ggcaatctat agagaaaata aagaatgata aacgccaaaa caagcatcat 2250301 gccaaaagcg gtggtgaatt caaacatatt gctgacaggc gcatggccgc ttgcagccca 2250361 ccttgtgatg aaatatccta ggtggcagaa aaaaccgaca atagaaaggg tgattccaat 2250421 gttggcccat cggtttggcc tgcccttttt atctttattc ccgcgtatgg ccccgccgaa 2250481 gattgggaca gcgattaaat acacaagaaa ggccgcataa agaaaatttc cgctcagctc 2250541 tgccatgaca tcactccctt ttcgcctatt tctgtgtttt gattaattct ttttggtcca 2250601 ccggttcagt cagtccggaa tcagccaata taaatgctaa atccttcttc aggccaaacc 2250661 agtttttatt ggtatgccct gctaccataa ctgcaccgtc ctgtgagtgc agccaaattc 2250721 ttcgatgctg ccagtacata ccttgaatga caccgatcat aaaaatggct ccgccgacag 2250781 caagcaccca gagtgtcaga tcctttctga ctgtaagtcc agtaatgttt ttcgtttcga 2250841 catggtcaaa tttcagcttg tatttattat tgcctgatcc ttcgatggtt tcttggatgg 2250901 cgacaaagct cttttcgcct ttcggtttgt ccggcgttat gatattaaag acaaaagccg 2250961 gattgttagg gatctttgtt tttgtgctcg gctctccgtc ctgattaaaa tagaagtcag 2251021 gcaggtagct ggcgatttcc accttgtaac cgttaccaag atcatagact gaatctggat 2251081 ccagaaggtt gatcttcagg ctcccaaagg atttttttgt ttttttatca atcagctgga 2251141 acaccatttg gtcaagctga ttctctttgt aatccacctg gtaaacggaa aaagaatcaa 2251201 aacgcagcgg ctgattgaca cggatgtctt cttctgttac tttttccagc ttcggcttct 2251261 cgccataaac aatttttcct tctctcttgt agagtacggc atcagtttga aagttctttg 2251321 ccactctacc gtccccgact ctgtcaatgg catctgcaaa tacctttttt tccgttttgc 2251381 tgttataggt ctctacgctg aattgattgt ttttcaaata atattttccg tctgtacccg 2251441 gaattgctgc ggtttcgcct tctctgaccc aaagcgtctc atcgacgtac atgccaggca 2251501 caaatctcag catcgcacca atcagaaaga tgatcaatcc aatgtggttg acatacgggc 2251561 cccagcggga aaagcgtcct ttttcagcaa gaatgctgcc ctctttttct ctgattctat 2251621 aatgtttttt ctttaataga gtaactatct tttctttcga ttccccgttc agtacagtaa 2251681 ctgtttcact gaacaagcgc tgccttctta aaaaggccgg gctccttctg acaccttggt 2251741 tttttaacgc tctatacaac ggaatgaccc gatcaaggct gcaaatcacg agtgaaatgc 2251801 cgatcgaggc aatgagcagc aaataccacc aagaaccata taaatgatga aacccgagca 2251861 aataataaag ctggccaaac gtgccgtact gctccttgta ataagtatca gcctgtgcgc 2251921 ccggaggcag ataggcttcc tggggaaaaa tggtgccgaa cgctgatgcg gcaagggtta 2251981 tgacgataag ccatattccc accttaaccg aggaaaagaa attccaaatt ttgtcgatga 2252041 tcgttttgtt ataggtttgc gaacgtcttg cgcttccgtc atatctcata tcagcgagcg 2252101 gaggttgagt ttcctgaaga gctcttccgc acgattcgca taaaacggtt ccgaccgggt 2252161 ttatatgtcc gcattcacat ttgacttgct tcatcccgaa gtctctccgg gttttatgag 2252221 attcatataa tcgtgtatca tgctttctgt catagtgccg gtcaccacct tgacaacttt 2252281 tccttccgga ttgatcaaaa aggttgtcgg aagcggagat acgtcatagg catcaagcac 2252341 ttggcgatct gtatccagaa caaccgggaa attgactccg taggatttca taaaattatg 2252401 tactgctatc tttgactccc caacatttac agcgacaatt tcaacacctt ggcttttaaa 2252461 atgcttatat tggtttgcca tataaggaaa ctcttttttg cacggttcac accatgtacc 2252521 ccagaaattc aaaaaaacac ctttcccttt taagtcactg agctcgatac gtttcccatt 2252581 cgtatcctct aggacaaaat tcggtgcgtc ggacccttcg gatatactct ctttgccggc 2252641 aaatacagcg ttgtaaatgg tatagccgag tgcgcagatt aaaacgagaa ggatgccggt 2252701 ccgaatgaat aaacgccttt ttttcttcat tgtccactgc ccccttcccc ctattgcaga 2252761 tccattcaat tatatcattg cacgttcatt tcacatttct tactttttga aggttatgtg 2252821 aaatttagaa agcgttttta ccgtgatccg ccagtgctct gagccttttt acttcgtgag 2252881 gcgtaagctc tctggcatcg cccgtgtgca ggcctcgcag gtttaaaaac gcgtattcct 2252941 cacgcttcag cttgattacc tcatgtccga tcgcttcaaa catgcggcgc acttgtctgt 2253001 tgcgtccctc atggatcgtc agctgaataa tgcttgtctg ctttttctta tccaaagaca 2253061 gcagcttcgc tttagcaggc gctgttttgc cttcctccag cctaattccg cgctccagct 2253121 ttctgagcag ctctttaggc gggattcctt tcaccttcgc cacgtatgtt ttgtctattt 2253181 catacttagg atgcattagc ttattggcga attcgccgtc attggttaaa agcaaaagac 2253241 cgctcgtatc atagtccaga cgcccaatcg gataaatgcg ctgcggaata tttttaaaaa 2253301 agtccgtcac cactttgcgt cctttatcat cttgcgctgc ggaaataacg cctcttggtt 2253361 tatataagag aaagtaaacc ggctcttcgc gttcaacctt taacccgttt acctcaatct 2253421 gatcagaacc ggtgacctta acacctagct ctgttactac tttgccattc acctttactt 2253481 ttccttcttt aatcagctct tctgcctttc tgcgcgacgc aactccggca tgagcaatca 2253541 ctttttgcag tctttccatg tctttcacct caagtattat cttacttttt tcaaccttaa 2253601 caaacaagct ttttcaaatt cctatgccaa atctaaaaaa aacgccgttt tcaggcgctc 2253661 ccaaataata acgtaacgat gatgatagat gcaactacgc cgattaaatc tgcaagaagt 2253721 cccaccttta atgcatcacc cattttttta atgccgactg ctccgaaata cacagtcagt 2253781 acgtaaagcg ttgtatctgt agatccctgc atgacggaag ccagcctgcc gataaaggaa 2253841 tcgggcccgt atactgcaat taaatcggtc gtcattccaa gtgcggccgt accggagatc 2253901 gggcggatca gagcaagcgg cactacttca gcagggatgc cgatagcgga gaaagccggt 2253961 tttaaaagat ccattataaa atcaagcgcg cctgatgatc tgaaaacagt tatagcgaca 2254021 agcattccga ctaaataggg gataatggaa aaggcaattt ctatcccctc tttcccgcct 2254081 tcgacaaacg attcatatgt cggaaccttt ttgatcgttc cataaagaag aattccggca 2254141 ataatgattg gaatcatggc taaagacagc cagttgatga tttccatccg ctcaccttcc 2254201 cttctttttg cggcggtaat aaaaataccg atcaatgata atggcaccga ttccggaaat 2254261 aagcgttgcc aaaatgcttg gcccgacgat atctgtcggc gttttggagg aataagccat 2254321 tcggacagcg atcaccgttg tcgggatgag tgtgatgcag gacgtattaa cagctaaaaa 2254381 agtaatcatc gaccggcttg cttccgatcg gtttccgttc agctttttca tttgttccat 2254441 tgctttaatg ccaagcggag ttgctgcatt tccgaggccg aagaaattcg ccataagatt 2254501 agataaaata tagcccatcg ccgggtgatc cggcggtata tcagggaaca gtttagatat 2254561 aaaaggtctg cacatccggc tgaaaatatc caaaagccct gactgctcgg cgattttcat 2254621 taagccaagc cagaaaacaa gcacgctcat caatccaaat gagatcgtaa tcgcttcttt 2254681 cgcaccctta aacacggctt catttacatc ttgcagagtt ccgttgcaca tcgcaaaaac 2254741 gagtccgatc acggttaaac tgacccaaat tatattgacc attttgctcc gcctgccgca 2254801 ttcagaaaga ttgatttaaa cgtttcaaaa aattgtttct tcggtttttg atgccgctca 2254861 ttttcataat agatcggcac ttttgcgatg gttgcatcgt tgaacatgat ctccatgtgc 2254921 cctacgatgt cagggatttt cgaggcatct ttttcccatg cttttttcgg cttgagcagt 2254981 gtggtattaa tttttacatt ttctttttcc tcttcggtca gcaaataggt gatatcacgt 2255041 ttgataaaag ccttcgattc ataaaatgtg cctttcagct ttggaatatc cccttttttt 2255101 gcaattaaat aggtttgata atgctcaaac acatagttaa acatcttcat atggtcatcc 2255161 caatcattag ggtcattaat ggtgacggct atcaggtcaa tgccgtcctt tgaagccgta 2255221 gagaccagtg tccgttttgc aagttttgta tagcctgttt ttcctcctgt gctgtacgga 2255281 taaagcatgg tcagcagttt gtttttgttt ttccatacgc tttccatcgt ttccgctttg 2255341 tatatttttg tgcctgaaat cttttgatag tctttcagct tcatagcata cttagttaaa 2255401 atggccatgt cataggctgt tgaataatga ttttcatggt cgtccaatcc gtgcgggttt 2255461 tgaaaacggg tgtttttcat accaagctgc tcggcttttt gattcatcat ataaacaaac 2255521 ccatcgaggc tcccaccgac atgctcagca atcgcgacag cggcatcgtt tcctgatctt 2255581 agcatcaggc catacacaag atctttcagc ttcacttttt gaccttctgt taaataaatg 2255641 gcggagcctt ctgttctgac agcatttgcc gaaaccgtca ctgtttgatc cattttgccg 2255701 gattcgatgg cgaggacggc ggtcataatt tttgtgatgc tcgcgatccg ccttttttga 2255761 tgctcatcct tggcatataa cactctgcct gacgcaccgt caataatgat cgcgcttttt 2255821 gcactgacat ctatagcagc atgtgctgta ttcacattta cggttgcaat aagaaaagaa 2255881 atcatgatca cgaatactgc ttttttgaaa atgcgcatgt ttgctcacgt ccttgtggtg 2255941 gtttgtacaa gtttatgcgc atgtccatca gttatgaata acaattatat ttctggaagc 2256001 aaacataaaa aaactctccc tgaaaaaggg agagtaaacg ttatctgatt ggcgccatgc 2256061 ttgatccgga cgcttcgtaa tgagccagct cttccctcat cttcagaaag gccgcgctca 2256121 acggcaataa taattgctca agcgacgcag gaacagcatg ataaaactca attgcgctga 2256181 ccccggtata agacgcccgg ctattttcac accacgtgtc ttttttcggc ataaagaact 2256241 cttcaatgca ttggtgatac acattataaa gtgttttttc cgctctggct tcctgaaaag 2256301 gctcctgcat caggagacga cggcacgctt ctgcgcctcc ttcacaaaat actgccattc 2256361 ttctcagagt gctaagcaca tcacagcagt atcctttttc aataggcaat tcagcctgta 2256421 aggactcaag cgtcgtttga tttaggtaat cgttcacggt attgacaacc attgataaga 2256481 attcgcctgt tttttgagtc tgcgctcgca caatcgaatg tcccatttcg tttggtatct 2256541 tcccctcatg tatttgtctc tcacattttg cttctttcat gatagcttct tccttatatc 2256601 ttatgatgat gaaaaagcgc gattcattaa acttctattt tatatcttcg aaggtttggt 2256661 taaagttttc aaaaaataaa tctgcttctt cttgaagaac gtcttcttcc gcattttcag 2256721 gcagcggcgg aagctcgtcc agcgttttca gaccgaattg ttcaagaaaa gtcggcgtag 2256781 taccgtataa aatggcccgc cccggaccat cggcacgccc tacttcacac aatagcgcct 2256841 tcgcgacaag actgtgtaaa atccgctctg attttactcc tctgatttct tcaatttctg 2256901 ctctcgtaat tggctgtttg tatgaaacaa tggccagtac ttctaaagat gcttgagaaa 2256961 ggccctttga cggcacttca atcagttttt tcaagtaagg cgcaaagtct tttttggtag 2257021 agagcatgta cgtatctgca tactcaataa gttcaatccc tcgtgtatct ccgcggtatt 2257081 cgtccgccac atccgccatg atcgtgttca gttcaggctc ttcgatttca agcactgtta 2257141 acagctgctt ttttgtaagc ccttcatcgc ctgccgcata aagaagggct tccacaatag 2257201 ctttccaatt cacgatatca agccccatga atggattcac tccccgtaat gtaaatatct 2257261 gaaaaattgt gctcctgttc aatgaggacc agctgatttt tcatcagctc aagaacagct 2257321 agaaaggtca ctactaaatg ttctttttgc tcatatggaa acagatccat aaagttaatt 2257381 ctcgttcctc tagatttcaa gctgtgcacg atttcgttca ttctggcttc gattggtatg 2257441 tcctgtcttg taattgttgt ttccatcggc ctgtttattt ttttgcgttt cagcactttt 2257501 tgaaaagctc cgatcatatc atagaccgtg acagagagct tttgctcaga ctgttttact 2257561 tcttttgcat attcactcaa atcactcggc ggtttcgtga acgatttttg tctttcttct 2257621 tcccgttctt ttaaatcctt cgccgcatct ttatattttc ggtactcaat cagcttttca 2257681 atcagttcct cccgcggatc ttcttcttca agtaattcat cttcaaaaag ctcctcctct 2257741 tgcttcggga gcagcattct gcttttaatg ctgagcagcg tggcagccat aaccaaatac 2257801 tcgctggcaa tgtcgagctc aagcacgcgc atcgtatgta catataataa atattgttca 2257861 gtgatcttcg ccacaggtat atcatatatg tcaatttcaa gacgattgat taaatgaagc 2257921 agcaggtcca atgggccctc aaacgtatca attttcactt gatattcttc catcatctca 2257981 ccattttcaa gtatcactct cattgccgga aaaactggct accctatagt ataagccacc 2258041 aaaaagctct cgtccaatac tatttcatat cctgttttga aggagtttgt acagaatatt 2258101 caaaacacaa gaggtgtttg ctcggagcgc agaagcggga gaaaaagcct ttgcttctgg 2258161 ttttcctttc taagaagcac tagaggccgg gcgttctttt ttccttttat cccttctatg 2258221 gtacactaaa agcacattaa aggaggaagc accttgtatc cgaaagctta tatagattat 2258281 ctcgttgagt ttcatgcgac acgggattat tttgaatgcc atgaaatatt agaagaatat 2258341 tggaaggaag atccgccaaa gaaacgaaaa cgctattggg tgggctttat tcagcttgca 2258401 gtggctttat atcatcacag aaggcagaat acagccgggg caaaaagact gatggcgaac 2258461 agcatccgga ttcttcaagc agaacaccgg gcagtcgaag acttagggct tgatcatggc 2258521 cgtttgctcg aacttatgca atcggtttac gaacaaatcg aaaccgtctc tgcctataaa 2258581 agcattatac tgccaatcaa agatgagaaa ctggaggaag catgcaggat cgaatgcagg 2258641 aaaaaaaagt atacatgggg gcagcccagt gcactcagca acatatttct tatcgacaaa 2258701 caccgtttgc gggatcggac tgacgtcatc cgtgaacgtg aaaaagaaat agaacgcaga 2258761 aaaaaaagca gagactgatc acagcctctg cttaattatt gtatgaaatg tcttgatcct 2258821 gctgaccttg acaacgttcg aaaaagctct gcgttaattc atttggaacc agtacttgcg 2258881 ttttgaataa atgctttaaa gcatccatca tctgttttcc gattccttga tggcgatgag 2258941 aaggattcac actgatatgc cggatctcaa cctcagaatc ctttttttcg actccgattg 2259001 ctccgacgat atcctcgtcc tctttccaaa gaaagagctg gcggtctgta tccgtttcgt 2259061 agtccttaat tgtctgctga agctgcttaa ggtctttttc attcggcata aacgaaagaa 2259121 gccccatcgc aatcttttca aacgattttt tataacgaat taacataaaa acccctctat 2259181 atccaaaatg tccagtctgc tattaacgga tacgaatagg tgatccgttt tctcacatta 2259241 tatcattttc gccatatttt taaactgttt tcagcaaatt attcaaatga gcggtttaaa 2259301 tttgccattt caatggcaga aacagcacaa tctacacctt tgttgcccgc ttttgtgccg 2259361 gcacgctcga tagcctgttc gatgttttca gttgttacaa ttccaaagat gacaggtaca 2259421 ccagtagtgt ttgctgcttg cgcgatgcct tttgcagctt cattgcagac ataatcgtaa 2259481 tgtgtcgttg cgcctctgat gacagtgccc aatgtgataa tagcatcata tttttttgtt 2259541 tccgccattt ttttcgcagc aaacggtatt tcaaatgcgc ctggaaccca agccacatca 2259601 atgtcatttg tgtctacgcc atgtctgagc agcgcatctt ctgctccgct cagcagcttg 2259661 ctcgtaataa aatcattaaa tcttcctact acgattccga ttttaagacc tgtaccaact 2259721 aaatttcctt gtatgatatt catatgattc ccatcctttt ttgtgatatt tgtgattaga 2259781 aatgaagtaa atgacctagc ttgttcattt tggtttgcaa atatttttta ttgtgttctt 2259841 tcgcctccat ttgaagcggc actctttctg aaatactgag tccgtagcct tcaaggcctg 2259901 cgatttttcg cggattattc gtcaaaagct tcatattccg gacaccgagg tcgcgtaaaa 2259961 tttgtgctcc gatgccatag ttgcgaagat ccggcaagaa tccaagcgcc tcattggctt 2260021 ctacggtgtc atagccttgt tcctgaagct tataagcttt taatttattg attaaaccga 2260081 tgcctcgtcc ttcttggcgc aagtacagga gcactccacg gccttctgcg gcaatttggt 2260141 tcagcgcggc gtgcagctgc ggtccgcaat cacagcgatg agagccaaac acgtcacctg 2260201 tgagacattc tgaatgcacc cggaccaata ccggttcttc tccgaacggc acatctccca 2260261 tcacaaatgc gacatgctct tttccatcta cctcatttgt gtatccataa accttaaatg 2260321 tcccaaaatc agtaggcagc gtaatgtcaa cttcacgctc gacaagtgtt gtcagattgt 2260381 aacggtattg aatcaaatcc ttaatggtga tcatttttaa ttgatgcttt ttcgcaattt 2260441 caatgagctc aggcactctc gccatcgttc cgtcttcatt cataatttca caaatgacgc 2260501 cggctcctgg agatccgcaa gcttcagcaa gatcaacagc agcttctgta tggcccgctc 2260561 ttttcaggac acctcctttt ttcgcaatca gtggaaaaat gtgccccgga cgctgaaaat 2260621 cagatggcac ggatttgctg tccagcaatg cttgaacggt aaaagatctt tcttgagcgc 2260681 tgatacctgt cttcgtttca cgatggtcta tgcttacggt aaatgcagtg tggtgagagt 2260741 ctgtattatg ctcaaccata gggtgaagat caagcctgtc tgcgatttcc tcactgagcg 2260801 gcgtgcagat cagtcctctc ccatgtgtcg ccataaagtt aatgacttcc ggcgttgcat 2260861 gctcggcaag agccacaaag tctccttcat tttctctgtc ttcatcatct acaacgatga 2260921 tgacttcgcc tttttttaaa gcgtccagtg cttcttctat cggatgaaac atgcaaatct 2260981 tcctctctaa aagccgtttt cgcttaagaa ggcttttgta atggtttgtt gggtcttatt 2261041 ttcattggct ttatgcaaaa atcgatacat atattttccg atcatatcgc attcgatatt 2261101 cactttagag ccgatcgttt tttctgaaaa gatcgtttcg ctgatcgtat gcggtattaa 2261161 ggagatcgtc actgtgtctt ctgtcaggcc gaatatggtt aagctcacgc catccacagt 2261221 aattgatccc tttaaaacca atgtttttgt taatgacggg tccattttta aatcatagta 2261281 aactgcgttg cttttctctt caattcgtgt gatttccgca gttccgtcga catggcctga 2261341 gacgaaatgg cctccgaaac ggccgtttgc cgccatcgct ctttccagat ttactttgct 2261401 tccttttgtt aaatcattca gtgacgtagc tttgactgtt tcaggcataa catccactgt 2261461 gaattgattt tttgtaaaat cagtgacagt cagacaaatg ccgttcactg caatgctgtc 2261521 gccaagatga acatcctcta aaatctttga gcatttaata gttaaggcca ttgcatgccc 2261581 tgcttttttc atggattcga ttgtgcctgt ttcttcgata attcctgtaa acatggtcac 2261641 catcctattc ctttgtcggt tttgccgtca gtttgatatc acggccgatt tgggttatat 2261701 cagtgaattg taataagggg acatctttca ttgattgaaa accttcaccg gagattaagc 2261761 tgggagcatg cgttcctccg attagtttag gggcaaaata gaagatgatt tcttgaaaac 2261821 agccttcttt gacaaagctt ccgtgaacag ctgaaccgcc ttccacatac accgacatga 2261881 tgccttcttc cgctaggatc ttcaaaacat caggaatttg aatgcgctcg gtttcaagtg 2261941 taaatatgtt cactccgaaa gctgaaagcc gttttttctt ttcctcgtct gcgcgtgccg 2262001 tcgtaaaaat ccatgtcggc gctatttgat cgcaaatcac tttagcgtcc tcaggaatcg 2262061 agagtacggt atcaagtatg acccgaaccg gctgttttgt tacattcggc agtctgcagg 2262121 ttaagctcgg attgtcggct ttcactgtgc caactccgac taaaatgctt tggtgtgttt 2262181 tcctgtattg ctgagcatcc tgtcttgcag cctctgacgt gatccatttg ctgtcacccg 2262241 tgctggtagc tatcttgccg tcaaggctgg cagccgcttt tagcgtgacg tacggaaggc 2262301 ctgtcctcat aaagtgcaga aatttttcat tcagcctctc cgcctggtct gccaggatgc 2262361 cttcccttac ctcaatgcca gcttctttca tcatgctgat ccctcttcca gccacaagcg 2262421 gattaggatc tctcatcgcc acgaacactc ttttgatacc agagttgata atcaattctg 2262481 cacatggcgg tgtttttccg taatggctgc acggttcgag tgtaacgtaa atgtcggcac 2262541 cctctgcatg tgctccagcc atatggatgg catgaacttc tgcatgagct tcaccatatt 2262601 ttaaatgggc gcccattccg acaatttgtc cgtcctttac gacaacagcg ccgacgagcg 2262661 gattggattc ggtctgtcct tcgccctgct tcgcaagatc taaggccagc ttcatataat 2262721 actcttccat ttgtttccct cccctctttt gttatttacc gtcaaaaaag ccccgaattt 2262781 ataaaaaatt cggggcttta ggtattttac gcaataggaa ataacactat gcatttttaa 2262841 acattttgca tagcggctca tcatccttct cccatccaga ctttcactgt cggcttcagc 2262901 ttaaactgaa tccaccgcgt gcttatgcac acgggtcacg ggctctaaag caaatgtgct 2262961 ttactaccgc cggtcgggat ttccaccctg ccccgaagga tacaatcttt attcatttgt 2263021 ccttattggt tattatagcg atccttttta aagtacgcaa tgaaataaac ttacaatttg 2263081 agaaaaacaa aacatcaccc ttcgatccga aaggtgatgt tttttaatca ttcacttttg 2263141 caaccttgat taatccgtcg atccgctttg atttgctgaa gtaagcctta atcttgtcac 2263201 cttcttttat atcagataaa tcctgattta atttttttcc gttgaagatg attttcgttc 2263261 cgttttctgc tactccatga tactctgagc cgtcaatttt cgtcacttta tattcctgga 2263321 tggtgtattc ctcttcttcc gaggacaagg tttgtccaat tgctgtcgga acatccttca 2263381 gctcaatatc atttatgtac atataaccgc ctgcaagtaa aagcaaaagc actaacagaa 2263441 tggtaatctt ggtttttatt cttcccattt ctaaacctcc agccaatatg aatctattca 2263501 ttcatatgag ttattccttt ttttcatgaa taaaaaaccg taaattctcg taaattatta 2263561 atataacgat gcataacggg aatatgtttc acatttctgc aaaaatttct tttctataga 2263621 tatacgaatt tatgttctgt ttttagggga tgaccgtaaa aaagatataa aaaaagcagc 2263681 cccaatggga agctgcttga tcctaatttg ttttgcgcat ttcgttaaac gggtagaaaa 2263741 caaactttga cgtacccgca atttgttttt tcgtgaagag gccaaggccg ttacggctgt 2263801 ccatggaatt gcgacgattg tcacccatca caaaatactt gttatcaggc actttaaccg 2263861 ggccgaaatc atcggtcaaa tggtcaaaac cgtcctgttt cgctctcttt ttattagccg 2263921 ccaaataagg ttcgtccacc tttttcccgt tgatatagag ctggtcattt ttcatctcaa 2263981 ccgtatcgcc gggaaggccg ataatacgtt tgacatagtg aacatcatct ccgtttaaca 2264041 cgacgatgtc tcctctatca aactcgccga tgtatttgac tgtcatatta acaaaaaccc 2264101 tttcacggtt gtgaagtgta ggatacatag agtcaccatc aacgacatac ggcgcaaaaa 2264161 taaagttgcg gatgagcaaa gcaagaacga cagcaatcac aattgctttt gcccattcta 2264221 atattgactt tttcttcgaa acattttctg atttcaactg atttcctcca ataaacaacg 2264281 gtcttcaatt tatgttatca cgaatcgaaa aaaaatccca ttaggaccat tgaagtgatt 2264341 ttacaaactg ttaatcttca tcttctaccc acatcatgcc tattttttct tgtcgatcat 2264401 aactaggcct gaaaatattg aaagaaatga atcgcataat tcagaagcga tggactcaga 2264461 agaaagagag ttctcatatg caaaatcttt agatcgtata taaagcatga ggttacgggc 2264521 agtttgttca tttactgcat tccattgatc tcccagtcca tgatacccat ggcacttgac 2264581 aaaacaatta acgtcatgaa ggttactgga atgtttgcgg caacctattt cacaggtgat 2264641 aaccgcaccc cgttttttgc tttcataata tgtttaaaat cattcaagct cgaaaacatg 2264701 gatcagcctc caaaaaataa atccaatata ttcccggcag ttgaagactc tttattataa 2264761 aactctgaat atccgcagtt cttacagtaa accactagaa atcggttatg ctgcacgtca 2264821 aacagctttg ataatcccgt gccggttgta gctatttctt tttgtccggc ttcagtacta 2264881 ccgcatttta tacagccttt gttgttcata tcgcgatctc cttttcatta catcacgttt 2264941 gtttgattta ttttactaca aaatatcaat cccaatgacc cgtactactt taaagtttac 2265001 ttaattttga ttacatacta attgggttcg tttctcagct tggtaaatct tctggagaaa 2265061 cggaaaagct ccatgaccaa aacattcaaa ctcagccaaa caccgccgaa ggcgtaaccc 2265121 gcagcaacat cactcggata ctgctcataa agtacacacg gctcagcccg atgaggaata 2265181 aaacgataat aaacaaaaaa atgcaacagt ttgcagacgc gtcttgtgag aatgacgaac 2265241 aaaaagataa gcacaaaaac caaaaatgac aaatgccgtt aaagtctgtt cgctcgggaa 2265301 tggatataat acatgacttt ccaaaggagc gtgaacagga tgaagggaat gaaagagccg 2265361 tctgattccc tcttcataaa gctccccacc aatgactagg aaaaataaga aagagagttc 2265421 gattttccga tcttgccctc tgaataccgt ccaaaaaaaa gttagaacaa taacggctaa 2265481 cagaacacct ctcgacgcaa aagctttctg aattgcagct gggcccagtc tatacccgat 2265541 ccaatacgac atgctcactc ccacagctcc ccaatccggc cgctaacatg cttagcaccc 2265601 agtttaactt ttcttgaaac acgagaacac cggcaaactc tcccggtcca agtaaagcta 2265661 gaagctctaa catcaagaca ataaacaaga cggcatatcc gtactgttcg agcaaccccg 2265721 tcaaaacttg catgtgattc tccttaaact tttttgttct tttatcattc ccaatccact 2265781 ttttgtataa tcagcacaat tttatcttca gtcgtccaac aacattgtct atggcgggat 2265841 cttctctcat acattctttt ttgacatagg aggagcaata gcatgaaatg ggaggaaaca 2265901 aaagatacgc agggagtttg ccaaaatttt gggcagttcg ttctgccacc gagtcaggtg 2265961 tttgtttgcc cacctcatcc cttgtcaatt ccccattttt cccgtttgag gttcgaaatg 2266021 gtaaagtatt tcacttagtt tcttacatga agaggtaaat tctttgctca ccgaactagg 2266081 atagcggcgt atggcgattt ctacattgca taaccactgg ttatttagtg agccgtgagc 2266141 aatgtatatg cactttgagt cagcacagga tgatcctatt acattcgcca gaaaagcagc 2266201 tgccgcattc agagtagtta aaagaataga cagatatctg ggcttccgga agctttaaag 2266261 gaggctcttt tttcgagcat ttttataaat caataaaaac aggcatctcc taaatatttt 2266321 tgccgataag tttacgctaa tcaactctag cactaataca tataaaaaat agaatgatat 2266381 gaaaggagac ttgatagtat gattgattat cctattaata taaacaacgt ttccgggaac 2266441 agtgtaatta acgtaggcgg cgcttttatg atcaggcctt taactttgtc caaatctgtg 2266501 tttggctccg gaggtttaaa cacaggaatt gtctttgaaa ataactttgt aagcaaagct 2266561 aaaatgatta atcatcaatt tactgatcaa aacgtcacca aaacttttta atgtattcaa 2266621 tacacggggg tcactaacta aacacctggt tttgccaacc gccatcagca ttcggcggtt 2266681 ttttattgaa catttttggc caataaaaaa agcttcctct ctaagaggaa gccttttgcc 2266741 tgccgattag ccttctacac gaacttcttt catgacatcg ccattagaca tgtttttcgc 2266801 gaattctaat ccgcttgtta ctttaccaaa tacagtgtga acaccgttca aatgaggctg 2266861 tggctcatga acgatgaaaa attggctgcc gccagtgtct tttccggcat gtgccataga 2266921 aagtgcgccc gcctcatgtg tatgcgggtt gccttctgtt tcacatttga ttgtgtatcc 2266981 cggaccgcct gtaccagttc cgtgcgggca tccgccttgg ctgacgaagc cagggatcac 2267041 tcggtggaat gtaagcccgt cataaaagcc ttcgttcgca agcttttcaa agtttgcaac 2267101 agttccaggt gcagcttcag gataaagttc aaattcaatt ttgttcccgt cttctaataa 2267161 aaagtaacct gttttcaatt gtatgcctac tttctttatt ttaattttca aaggagatta 2267221 tgtataggtt atagcctgtc tctccttgtc gcggctatta taccacacct ttcgggggaa 2267281 aacgaatctc ccgagcttta ctaaaaaata aaaatgaaac ctgaatctct ttatctccgt 2267341 ctaacctaac ggaactgtat ttttcatgat tcaggtcctc acaaagcagc actatccagc 2267401 tgcttgtgaa attgaaggag gtcaaactgc tttgaagaaa atttggattg gaatgctggc 2267461 agcggccgtt ttgctgctga tggttccgaa ggtcagtctc gcggatgccg cagttggaga 2267521 tgtcattgta acactgggtg ctgatttgtc agaatctgac aaacaaaaag tgcttgatga 2267581 aatgaatgtc cctgataatg ccacaacggt aaccgtgacc aataaggaag aacatgaata 2267641 tttaggaaaa tatatatcga acgcgcaaat cggatcgaga gcgatttctt catcgtcaat 2267701 caccattgcc aaaaaaggct ccggattgaa tgttgagacc cataatatca gcggcatcac 2267761 agatgaaatg tacctgaatg cactgatgac agccggtgtt aaagatgcga aggtgtatgt 2267821 tacagcaccg tttgaagtat ccgggactgc cgctttaact ggattgatta aggcgtatga 2267881 agtttcttct gacgaagcga tctcggagga tgttaagcag gtcgccaacc aagagcttgt 2267941 cacgacatca gagcttggag acaaaatcgg taacgaaaat gcggcagccc tgattgcaaa 2268001 aatcaaagaa gagtttgcta aaaacggggt gcctgataat aaagctgaca tcgaaaaaca 2268061 agtggatgac gcagcttctg atttaaacgt cacacttaca gacagccaaa agaatcagct 2268121 tgtctcccta ttcaataaga tgaaaaacgc tgacattgac tggggacagg tcagtgacca 2268181 gctagataaa gcgaaagata agattacgaa attcatagaa tcagatgaag gcaaaaactt 2268241 catccagaaa gtcattgatt tcttcgtatc tatctggaat gcgattgtat ctatattcaa 2268301 ataagaaaag cgccgaaaaa tcggcgcttt cttttattgc tttacacccg ttttaaatgg 2268361 cagatcaagt tttacaatat cttcgtatgt ttctcgcttc acgactaaat gagcctcacc 2268421 gttttcgaca aatacaacgg cgggtctcgg aatacggtta taattgttgg ccatgctgta 2268481 tccataagcg cctgtacaaa aaacggcaag aagatcgcct tcttttactt ccggcaggtc 2268541 aatatcccaa atcagcatat ctccgctttc acagcacttt ccggcaattg ataccgtttt 2268601 gtcatgcgct tctccgatcc tgttggctgc cgcagcttca tatttagctt ggtaaagcgc 2268661 aggacgaata ttgtcgttca tgcctccgtc tacagccaca tattggcgga cacccggcac 2268721 ttctttttga gagccaaccg tataaagagt tgtgcctgcg tctcccacga gagaacggcc 2268781 cggttcgatc caaatttccg gaatgtcaaa accgtaacgg gaagcatttt ctttcacagc 2268841 ttcgataatt ttttcaacgt attcagtggc atgaagcggt tcatcatctt ccgtataacg 2268901 aatgccgaaa cctcctccaa gattcagcac cttggataca aatgaatatg aatctctcca 2268961 ttcgtctagt tttttgaaga ttttttccgc tgctaacaca aaaccggccg tatcaaagat 2269021 ttgcgagccg atatggcaat ggacacccag cagctgaatg tgttccgatt gtaatacttg 2269081 ttcaatggcc cgttcagttt gtccgttatg aagatcgaaa ccaaactttg aatcttcctg 2269141 gcccgttgta atgtagtcat gcgtatgcgc ttctactccg ggcgtgatcc gaagaagaac 2269201 atcgatggag tgacccgttt ctttacatag gtcttcaaga agcgcgattt catagaaatt 2269261 atccaccaca atgcagccga tgcggtgctc aagcgccatc cgcagttctt ccctgctctt 2269321 attgtttcca tgaaagtgga tgcgttctgc cggaaagcct gctgcaacag ccgtatatag 2269381 ctctcctccg gatacgacat ctaaagaaag tccctcttcc tcagcgagct gaatcattgc 2269441 gactgatgag aatgctttgc tcgcatatgc cacctgtgct ttcagccctg cagaaataaa 2269501 cgcctgctta aagcttttag cacgctcacg tattaaagcc acatcatata cgtaaagagg 2269561 tgtaccatat ttctccgcta aatagagagc atccacacct ccgatttcta aatgaccatg 2269621 ttgattttgt ctgcttgtgc cgtgtaagaa caatgtcatt ccctctttct ccgcttatgg 2269681 atgaaaggac agttttatgg actgtccctt cataattaag acatacatta tcatactctt 2269741 cagtcagttt caatgcgatt atgaattggt aggctgcctt aagcgatttt tggggtgaac 2269801 gatgctgggt cttacttttg cgccaggttt cgctgtgcgg acaagaacct gccacagcgc 2269861 ctttccgtta aagggaatca gcggccataa gtacggtgtc tgaagggatt tgatgcttgc 2269921 catggcaata attagcactg taaatccgat gacgagccct tttatatgaa ataaagcaac 2269981 gagtatcatg aggacaagac ggctcatttt gtttgccaag cttaattcat aactaggcgt 2270041 cgtaaaggtt ccaatcgccg caagtgagac gtacagaatc acctcaggag aaaaaaggcc 2270101 gacctcaatc gcaatctgcc cgatcagaac agcggcaatt aaacccattg ctgtcgataa 2270161 agccgtcggt gtgtgaatgg cagccattct gagaaactcg attcctaagt cagctaaaaa 2270221 tatctgcagg atgatcggga tatgcgtatc tttatttaaa ccgataaatt tcatgttgtc 2270281 cgggagcaga tcaggctgaa gcacaaagag aaaccagatc ggaagaaata aagtagaagc 2270341 aagaataccg aaaaatctta cccatcttaa aaaggtcccg actgaaggcg cctgcctata 2270401 ttcttcagca tgctgcacat ggtgaaataa agtcgtcggg gtaatgatca cactcggcga 2270461 tgtgtccact ataatgataa catggccttc tagaacatga tttgcggcca catccggtct 2270521 ttctgtatag cgcacgagcg gaaaaggatt atagctttga ttaacaatga attcctcgac 2270581 agttttgtct gccattgtta atccatcgac atcaatggat gcaatttctt tttctacgat 2270641 ctcaaccaga tccggatcag ctatatcttc tatataacaa atgcttaaat ccgtctttga 2270701 ccgctcacca actttagtca tcttgactcg aaggcgttcg tctctgatcc gccttctgag 2270761 aagggccgta ttgacgacga tattttcaac aaatccgtct ctggctcccc tgaccacctt 2270821 ttccgtatca ggttcttccg ggtttctgcc cggatagctt ctgacatcaa ttataaatgc 2270881 gaagcctgca ccttcaacaa tgacagcgac gagcccggac agcacttggt cggtggtttc 2270941 atccaaggtt tttacttttt cgacctgggc gttaagcagc ctgttttcga cgatgtcgac 2271001 cagctcatca gggtcttctt tccgattgtt aatggcaaca agctctctca ttaaatgaat 2271061 aatataggct gtatcgcata atccatttag atagtaaagc tggatctctt tatctaaaat 2271121 cgtgagcttg cgaacaccta catcatagct cgtccccatc ccaacacggt ttttgaaata 2271181 ctcttcattt ttagctggat tccgataaac ccgaattttc tcttccttgt ggtccggcat 2271241 gatacccgct cctttctaaa ataaactcga ccgctttcat ggtgattggc gacccttttg 2271301 agatatcgtc ttttctgccc attttgccga tatccccgat accgacaata agcgggagat 2271361 caagtttatc aaggcaatag actgtatctc cactcattct gtggtcatca aattcccttt 2271421 ccccgacttt atcgacgccg tattcagtta tttctccatt gcggtcaatg cttacatcga 2271481 ccctggtcca ttcagcctga tgtgtttttg acgcgaccgc aatcacaccg agcacttcaa 2271541 tagacggatg ggttgcgaca taggttagag cggcttctcc cgggccctct ccttgaaggc 2271601 cggagtcgtc aaacatgaca aatacaggat catacggtgc tgaggcgatc agcttgacaa 2271661 gctcggcgcc gctgcgggtg gaaggattcc cttttgattg tgaaatacat cggcctccca 2271721 ctttgcttgc ggcgtattca attgttttag cggcataaac atccccgtct gttaccagta 2271781 tgaccttgcg ttttgtcgtc atgtcggcat tatcctttcg gtttgaaaat aacagctacg 2271841 ataaaggcga aaagaatagc ggctgagata ccggccgagg tcagctcaaa aatccccatg 2271901 ccgattccga taaatccgtg tatatgcgcc tgatgcatgg cgccgtgcag aagactgtga 2271961 ccgaagctga cgatcggaac ggtggcgcct cctccggcaa attcaataaa tttatcgtaa 2272021 atgccgaaac catctaatat tgcaccgatt acaacaaatg atgtcatgac atgagctggc 2272081 gtcaatttaa aaatatccaa gagcagctgg ccgacgatac agatggcccc gccgcagaca 2272141 aaagccaaaa ggtagtccat attaagatgc acctcctgca cgctcaaata caaccccgtg 2272201 ggcgatagtc gggatggttt ctttttgctg gatcatcgtc gggcttaata gcgccccggt 2272261 cgccacgaca aatacacggt ttagttttcc ttctctcagc tgcttaaaaa tatgagagta 2272321 ggtgacaacc gctgaacaag cacagccgct ccccccggca aagacctgct gatccggagt 2272381 gtaaatcaga agcccgcaat catcatgctt tgtgccgact ggatatccat cttcttttaa 2272441 aatgtctttt acgattggag aaccgacgcc tgacaggtca cctgtcagga ttagatcata 2272501 gtcatccgct gtccggttga gatctttaaa gtgctgctta atcgtatcag ctgcagccgg 2272561 agccatagcc gatcccatat caaaaggatc tgtaattcct aaatcagaaa ccttcccgac 2272621 agtcgcactt gtgatttgga tatcacccgg tgtctgactg atgacaactg caccgcttcc 2272681 ggttacagtg gaggtagcag tgtccggttt ttggcctccg tattctgtcg gatagcgaaa 2272741 ctgtctttcc gcagttgcat tgtgactgct ggtggcagcg agtgcccttt tggcaaaccc 2272801 tccatcaact aaggctgatg cgacagccac tgtttccatt gatgttgaac aggcgccaaa 2272861 catacaaaga aatgggattt tcaagtgtct tgccacatag ttagccgtca cgttttggtt 2272921 cagcaagtcg cctgccagca ataggtcaat atcatctttt gtcagattgt ttttttgaag 2272981 tgcaacatta acagcgtctt ccatcagctg ccgttccgcc atttcccagc ttttttgatt 2273041 acaatgcatt tcgtcatagg ttttatcaaa taaagagcca agcggtccgt ctttttcctt 2273101 tggtcctgct gccgttcccg ctgagttgac aaatatggga tgttcaaata cccaggtttg 2273161 ctttcctgtt aatttcattt tcttctcctc ctatgacatc agtttctcaa aagcaaaccg 2273221 aatcattcca acgatgtatg cagctacaac tccgaaaaca ataacatttc ctgccagttt 2273281 aaacatattt gtcgctactc caagcactaa tccttcgctt ttatattcaa gagccgcact 2273341 tgccatactg ttggcaaaac ccgtgacagg tacggctgaa cctgcgcctg cgaattgtcc 2273401 gattctgtca tagattccaa accctgtaag cagggcagaa attaatatca gcgttgcagc 2273461 tgttggattc cccgcagttt tttcattgaa atcaaaaaaa tggatataaa aattttgcag 2273521 accttgcccg attgcacaaa tcagtccgcc cactaaaaag gcttttacac agttccagac 2273581 gtaaggcggc ttaggctgat atgttttcac ttttgatttg taattttctt ttatgtttgt 2273641 catcttgaaa cctccttatg aatggtcaat aaagtacagc cagtgaaata aagatcccgc 2273701 gattttccca atcacgatgg ccattaacag aataatgatt ttacttctga gcccgattcg 2273761 tttcgccaaa atcggcagga catttaaaac ctctgtaaga gcagccgcta gcatcccgac 2273821 gaacaaacct gccagaagcc cgaccggcac agctatccat tttgttagat aaagatgatt 2273881 catatgaagc gtctcccatc ccccgcaaac cgcgccaaga ataacagccg cttcataagc 2273941 ctgaacaaat ctcattgttt tggtgagctg catcagccgc ggaatgattc ccattacggt 2274001 taaaaaagca acgaaacccg cccccaccgt tatgcctccg ccgagcccga caaaaatgat 2274061 gaacaataca ctaacgatca tgcagatcct ttatggtttc ttgattctca tgcatggcca 2274121 catattgatc gagatcaagc tgatagttaa acatctcaac ctccagcggg ctgggctctt 2274181 catttaggcg ctttttaaat atgtggttaa aaaacacgat catccccagt cccaaaccga 2274241 tgctgtatgg gatttgaagc aaatatggat agtcattcct ctctccggtt atgatttcat 2274301 atagtgcgat atgaacatct ctcatgctta catcctcatg aaagttcatg atggcaagac 2274361 acgatccaat aaacagaagc agccagacac cgataaatag aaccgttgat aaatttcgct 2274421 ttcgatactg aatttcaaca atggtttctg ctccgcctac ggtttgaaca tcaattgtcg 2274481 ggtcttgtaa atgaatggct ctgaggactt gtatgatatc cagaattacg atatttttat 2274541 ctttttcgct cacctgataa agcggcatag ccgaaagttt ctttttcagc tgaagctgcc 2274601 cttctatttg cgcggcatct ccaacggtaa taatatcccc tggatgtgcc agcactcggt 2274661 ggcgaagccg gataaatatt cgtcgttcca tcattgatca ccatctttcg gtggttatat 2274721 atgtagtatg tggttcgatt ttgttctcat tcatccgctc gaaaagacca taaattacca 2274781 cgcttttgca caaaaaagct agcctgcact gcagactagc catccgtatg atccatttga 2274841 accttgatct gttttaatat tttcttttca agcctggaaa cctgcacctg agagatcccg 2274901 agccgctcag ccacctcgga ctgtgtctgg tctttataat atctgagata gacgattagt 2274961 ttttcccttt cctccaaatc gctgatcgct tctttcagcg caattttgtc aaaccatttt 2275021 tcttctgagt tgtcagcgat ttgatcaagc agggtaatcg gatctccgtc attttcataa 2275081 acggtttcgt gaatcgaaga tggagccctt accgcctctt gggccagtac aacatcctca 2275141 gcttcaatct ccaaatggtc agcgatctcc tgcaccgtcg gcactctgcc cagtgttttc 2275201 gaaagctcat ccttcgcgcg ccggattttg tttccaagct cttttaatga ccgtgatacc 2275261 tttacggttc cgtcatcacg gataaatcgt tggatttctc cgataatcat cggcactgca 2275321 tacgttgaaa aacgcacatc ataggttaaa tcaaatttgt caacagattt taacagcccg 2275381 atgcagccga tctggaagag atcgtcaggc tcatatcctc tgtttaaaaa ccgctgtacg 2275441 acagaccaaa caagacgcat gtttttttct atgaggaggt ctcttgcctg ctggtcgcca 2275501 ttttggcttt gtttgattaa ttcctttact tcatgatcct tcagctgagc gtttttgccg 2275561 tttttcttaa cctccacatc cataacaaat ctccttaatt acaaagcgct ttgctttttg 2275621 ataagtgctt tgttaagcga atcgttgttc ccatttcagg cgatgaatcg atactgacat 2275681 catccatgaa attttccata atggtaaagc ccattccaga gcgctcaagc tcaggcttag 2275741 tcgtaaatag aggctgacgg gcttcttcaa gatctgtaat gcctaagcct tcatcacgaa 2275801 tagtcatata tacgacatga tcttccagcg tcactgaaat gtaaactttc ccttcacagt 2275861 tctcttcata tccatggata atcgcattcg tgacagcctc tgacacgact gttttgattt 2275921 cagtcagttc atccattgtc gggtccagct gagctataaa tgaagcaact gtcacacggg 2275981 cgaacgattc attctgactg agggcagaaa actcaaggtg catttcattt ttcatgatgc 2276041 cacccccagt gtcaggagtg cctgctgttc agattgttca aatcggataa ttttaaacag 2276101 acccgacata tcaaacaatc gcttcaccgc aggagagata gcgcaaacaa ccatttctcc 2276161 gccaatttgc ttaatttgct tgtatcttcc taaaataacg ccaagccccg agctgtccat 2276221 aaaggaaagg tcctccaagt tcagcacgat atggcgaata tcatccttct ccaatgattg 2276281 agtcactttt tgcttcaggg tttcagccgt atggtgatcg agttcgcctg ttaatcgaat 2276341 acaaagcaca gattctttga cattcatgtc aattccaagg ctcatgctca ttcctccttg 2276401 atatgatcgg ataatgagtg tttcgatttc gacggaatga attccttcac cgtgacaaaa 2276461 ctagtggtca ttcggcataa ttacttaaat tttgtccagt ctcccatcgt ccgctttaag 2276521 aatgtgataa acccggcttt cttcatatct tcttttgcag caacaggact ttcagcgagt 2276581 acttctccat cctttttcag aacaagagtg ccaagctctt ggcctttttg aatcggagca 2276641 ctaatattgt ccttcatctt gatttctttt ttcacatcgt tcatatcctc gccttttttc 2276701 gtcaatattg aaatcggctc agatgtagtg agttcgataa atttttgttt cccttttttg 2276761 acctttactt ttgctactgt ttgatttcgt ttatataaag gatgcgtttc atattggcta 2276821 aaggcgaagt caagcatttt tgtcacttgc gcgtttcttt ctttaggcgt gctcgctccg 2276881 aatacaaccg ctatggcccg catgtttcct tttttagccg aagcagtcag acaatatttc 2276941 gcttcgcctg tatagcctgt ttttacgccg tctacaccag gataaaattt gataaggcga 2277001 tttgtattta caagccaaaa ctttttatct gtattttcac gcagataatc ttcatacgtg 2277061 ccggtaaact tcgtaattga ttcgtatttc aataattcct tagccatgat tgccatgtca 2277121 taagcagagc tgtagtgtcc ttcctcggtc agtcctgttg ggtttttaaa ggatgtattt 2277181 ttcaatccca gctcttttgc ttttttattc attttcttca caaattcttc ttcagagccg 2277241 gaaataaatt cagccatggc gacggaagcg tcatttcccg aagcgattgc gatgcctttc 2277301 agcatttctt tgacagtcat ttcttcgccg ggctcaagga atatctgtga gccgcccatt 2277361 gacgccgcat gctcgcttgt acggacctta tcactcattt tgattttgcc tttatctaaa 2277421 gcttccataa tcaaaagcat cgtcataatt ttcgtcatgc ttgcaggcgc cagtctctca 2277481 ttgctgttct tgttgtaaag cacttttccc gtgtcacgtt ctatcagcac cgcagacttc 2277541 gcttcatgag caagctccga tgtacgtttt ccgtcttgtt ttgcaaatgc agacggtgca 2277601 aatgtaagca gcattatacc aatcaacaaa gtggataaaa gacgtttcat ctcaaaagcc 2277661 ctccatttca taatcctttt tattttttcc aagcgtgatg gttttatacg ccactgatgg 2277721 aaaatgtttc gaattttggg cataaaaaaa gacagctgtg tgatatcaga cacagctgtc 2277781 ttttggtcct gcattgattc atatttattc gtactgagcg acgatcgctt taacaagctt 2277841 taagaatcca gcttttactt tttcggtcac ttccataact tcatcgtgac ttaaaggctg 2277901 atccagaatt ccggctgccg cgttagagat gcaggaaatg ccaagaaccc gcattcccgc 2277961 atgattcgct acaatgactt ccggaacagt agacatgccg actgcatcag agcccatcgt 2278021 tcttaagaaa cggacttctg ccggtgtttc gtaagaaggt cctgtcacag cagtgtacac 2278081 gcctttttga attgggatat taaggtcttt cgcaatcttt tcagccaggc tggacagatc 2278141 tttgtcatag gctgaagaca tatctggaaa tctggcgccg aaatctgctt cgtttggccc 2278201 gattaacggg tttgttccca taaagttgat atgatcggta ataatcatta aatctcccgc 2278261 acggaattca gtgttgacac cgcctgcggc atttgtcacg atcaacgctt ccacaccgag 2278321 cgctttcatc acgcgtacag ggaatgtgac tttctccatt gagtagcctt cataaaaatg 2278381 aaagcggccc tgcattgcaa tgacggaaac tccttcaaga gtgccaagca caagctgtcc 2278441 ggcatgccct tcaacagtag ataccgggaa ttcaggtata tcttcatatt tcagcttgac 2278501 cggattttcg atttcgtccg ccaaaatgcc aagacctgag cctaaaataa ggccgatctt 2278561 tggagattcc ggcaggtttt gtttaataaa agcggctgcg cgttcaattc tgtccttcaa 2278621 gaaacagtcc ccctattgta ataaagataa aaagcttttc ccgtatttcg gtttatttgt 2278681 ttggaaatta tcagcgatcg ttgcgccaat atcggcaaat gtatctgcaa gcggcagcat 2278741 ttgcgctttc ttatgttttt tgctgtaagc gagaatcggc acatactcgc gtgtatggtc 2278801 agtcccatga tgaatcggat cattgccgtg gtcggctgta ataattaaca gatcgtcttc 2278861 tctcattttt tcaaacactt ccggaagccg cgcatcaaat tcttcaagcg cgcgtccgta 2278921 gccttcaggg tcacggcggt gtccgaataa cgcgtcaaaa tcaacaaggt tcgcaaagct 2278981 cagacccgta aaatcttctc ccagcgtatc gatcaccttg tccattccgt ccatattaga 2279041 aaccgttctg cgtgaagaag taatgccttc tccgtcgtaa atatcagaga ttttaccgat 2279101 tgaaatcaca tctaagccgc agtctttcaa ttcattcatg acagtgcggt caaacggctt 2279161 cagcgcataa tcatggcggt ttggcgtccg tttgaattga cccggctctc cgacgaacgg 2279221 ccgtgcaata atgcggccaa ccatatattt cggatcaagc gtcagctctc tcgccgtttc 2279281 gcaaatgcga tacagctcct caagcggcac aacctcttcg tgagcggcaa tttgcagaac 2279341 agagtcagca gacgtgtaaa caattaaagc ccctgtctcc atgtgctcct ggccaagctc 2279401 atccaaaatc gctgtgccgg aagccggctt gtttccaata attttgcggc cagatctctt 2279461 ttccagctct tgaagcaatt catcaggaaa gccttccggg aacactttaa acggtttatc 2279521 aatgtataaa cccataatct cccaatggcc ggtcatcgta tctttgccgt ttgacgcttc 2279581 ttgcattttt ccataatagg caagcggatg ttctgttttt tctacacctt tgatatcttc 2279641 gataagacca aggccgagct ttgccatatt cggcatatgt aatccgttca tatgctcggc 2279701 aatatgaccg agcgtatgag cgccttcgtc attaaagtca gcggcatccg gcgcttcgcc 2279761 gattccgact gagtccatca caattaaaaa cacacgatta tatttgtatg caggcatctt 2279821 gaaagcctcc tttttttcta tacgtctatt gtatcgctaa gaggtctgac aactcaagta 2279881 taaaccgttt tcattcccgt tgacaatgta tttggaaata atgagaaact tcaatatttt 2279941 ctgtcgctct aaacaaaaaa gccgcagcca cctgcggcta tgctcgcgga tgaaactgct 2280001 tgtacacatc cttcagcctt gttttcgtca catgcgtata aatttgcgtc gtggatatat 2280061 ccgcatgacc gagcatttcc tgcaccgctc ttaaatctgc cccgttctca agcagatgcg 2280121 tcgcaaagga atgcctgagt gtatgcggag tcagctcttt cttaatgccg gcttccaatg 2280181 cgattttttt caggttcttc caaaatccct ggcggctgat ctgtttgccg tgatgattta 2280241 aaaagagggc gtcagataca ttatttttta acagttttcc cctggctttt gtcatatatt 2280301 cctcaatggc ggaagcagcg gcttcaccga ttggcacaat ccgttctttt cttcctttgc 2280361 cgaagcatcg gataaacccc atagataaat gaacatcagc cgttttcaat tcaatcattt 2280421 cactgactcg tatgcctgtc gcataaagca gctccagcat tgctttatcc cgatatccga 2280481 aagggctcgt cagcttaggc gtgtccaata accgctcgac ttcattgagc gcgagcacct 2280541 tcggaagcgc ccgttccgtc ttttgtgttt cgatatgaac ggaagggtcc ttatccgtta 2280601 ctttttccct gagcagaaat tgatgaaaag agcgaatgga tgccaaatgc cgcgccgatg 2280661 tcttgccgga tttccccgag tccttcaaat gctttaagta ttggataata tgtatgcggg 2280721 taacgtgatt ccaatctgta acatgaaggg tttctgttaa gtagagagaa tagcttttca 2280781 agtcacgttc ataggatacg atcgtatttt gagagagccc tctctctacc ataacgtagt 2280841 ggatgaaatc ctttatttga tctttcactc ttgatctact ccccgttttg gtaaaaaaag 2280901 atcaaccggt cgaaccatcc gcctttttca tcctgatcca tttcaacaac ttttacagcg 2280961 gagccttccg gtttatcata ccgatgatag ttttcatact cttgattcac ccatatcata 2281021 gcataataga acaaagcggt aaaaccggta aacaggatga aaactttcaa tgcatcgaca 2281081 gctgttttca ggaatcttcc catgtcctaa tcgatccttt ccctatggtt ccagttatat 2281141 aaaccatatg ccaaatcaga aaggttttat acatagaaac agcaaaaaac cctttcccca 2281201 tgagaaaagg ttcgcgctcg gcaccgtcta ttcagtttct tttccgttac agcggtggca 2281261 aatgccgtga aacgtcaatc tatgatcttt aatcttaaat ttccaatcac gttcaatgat 2281321 ttcttccacg tcttcaagca aatcttcttc aatttcatca acggctccgc actccatgca 2281381 caccaagtgg tgatgaaagt gagctgcgcc ctctttccga aggtcgtaac gggacacacc 2281441 gtctccaaag ttaattttat ctacgacttt taattcagtt aataattcaa gcgtacggta 2281501 tactgtagcg agaccgatct caggagattt ctcttttacg aggaggtata catcttctgc 2281561 gcttaaatgg tcttcttcgt tttcaagcag cactcttact gtcgcttcac gctgtggcgt 2281621 aagtttatag ctggatgagt gcagttgttt cttaatacga tcaatacggt tttccatgtc 2281681 tttccctcct acgccgcatt ccatgactca ttataacaaa atacgcgcag agttccaact 2281741 ataattatta taaactgata aataaaatgg ttttctttta ataatgattt taaaaaagtc 2281801 tagatgtaag cttttccatt aaaacaggag ataagtatgc ttcaaagaga gatgaaatca 2281861 gcgctaaaaa cagaatgacc agcagcacaa aggcataccg cccgaaccat tgaatcggcg 2281921 cgtcatgcag gcttcgtttc acgaacagct gtctgattaa ctttaaagaa aacgcaattg 2281981 cacatgtgcc cataatgaga taagccggaa tcagcagcac attttgcggc aaaacggaga 2282041 caaatgatag gaaaaacccg cttactccca tctgattgac taggaacccg acagtaaagc 2282101 cgacgacgat ccctttcaga aagatcataa tgaaaataat cggcatccca atgacggaaa 2282161 ttcccagtat ccacatcagg cctaaatact ttgcattatg aaagatactt tgcccaaaca 2282221 tatcagctga acttgcctgt tttccatccg aaagctgtcc aaaaaattga cttaagtagt 2282281 agtataaatc ttctttctgg ctgatggtca tactgttgac aataatcgcg ccaaagatga 2282341 cacccatgaa aaacagcact gacacaaata tataaagaga gagatgatct ttgacatgcc 2282401 tgagaaacat gtccttataa gagatttttc gcataccgtt tcctcccgcc cgctctagtg 2282461 atttgattta atagattgta tgaaagaaac agaaaaacat gccctttttc aaaaagaaac 2282521 aatagagatg aatgctaggc ggctttttgg ggcacaaaaa aatccttatc atcaactgct 2282581 gtatgatcat aaggattctt atgcttccgt ttattcaaaa tctctttttt gctttttgtc 2282641 attcttccat gtgtgctgaa agatggtgtg ctgcctcttg ataataagac gtcacgtccg 2282701 ccgtttctca atcgatgccc ccgcttcttt ttcgcttggc tttttgccat gtgatcactc 2282761 ccttttttat tttcatagta atgataacaa aattgaacaa tgataagaaa aaaacagcac 2282821 ctgctacgac aggtgctgtt tagctacatt tatttcactg ctgtaagagc tgcatgctcg 2282881 acagctgctg ctaccgcatg atggactttt gaatcaagcg gctgagggac aacatcacct 2282941 tgtttagtgc aagctgcgat ggcctctgct gctgcgacaa gcatatcatg attaatctcc 2283001 gtgctttttg cgttaagcgc tcctctaaaa atccctggaa aaccgagtac attattaaca 2283061 gaacgcccgt cagctgcata tgcggcgcca gcctgcagtg cggcctccgg ctcaatttcc 2283121 ggcttcggat tcgataaagc cagaatcact tgaccagaac gtacaaatgc cggttttatt 2283181 aaacccggaa cgcccgttgt agcaatgaca atatcacatg tttccataag ctcctcaata 2283241 ctggaaactg cctgtccgcc gtattgttcg agacggttca ttgctgactc tgatttgtct 2283301 gttccgtata cagcattcac accataagcc atgaacatcc ggcagatggc cacgcctgct 2283361 gcgccaaggc cgatttgccc cactttcgct tccttcaggt caacccccgc actcctgcat 2283421 gccgaaatgg cagctgccag cgtcactaca gctgtaccat gctggtcatc gtgcataaca 2283481 gggatgttca gctcctcttt taggcgatcc tcgatttcaa aacaatgcgg cgaaccgata 2283541 tcctcaagaa ggatgccgct aaagcccgga gaaatatgtt ttactgtttt gatgatttct 2283601 tcaggatcac tcgtatcaag cagtatcgga atgccgctaa tacccgccag ctgatcaaat 2283661 aaagcagcct ttccttccat gacaggcatg ccagccacag agccgatatt cccaaggcct 2283721 aaaattgcgg ttccatccgt tacaattgca acagaattgc tgatcgttgt ataaatagaa 2283781 gctttttcag gttctttttc gatcagtcgg cacacgtccg caacacctgg tgtgtagaca 2283841 cgtcccagct ctgccagtga acggatcggc attttgcttt tcatttggat ttttccgcct 2283901 tcatgtgcgg acaggacttc atcagatacg gtgtgaagcc tgatcccttc tccgagggcc 2283961 tgtacagccg cgatcacttc ctgaagctgt tcttcattct ccacttgaac ggtaatattc 2284021 cgcattgtgt aattgggtcc gacttttacc gtctccactt caccaatatc cccgcccaga 2284081 aggccgatgg ccgtagccac ccttccaaga tttccgggaa ccgaaggcgt ttcgatcatc 2284141 agtgtccgaa tcatgtgttt cgctatcatt cagtgatcct cccctattag cctagttttt 2284201 cggctttaac tgtattgttt ttcgtatacc atataaattt tcctgtataa ccatagataa 2284261 ttgcaagacc tattgctaca aaactgagcc acataaacgg cagataagag aaggtagaaa 2284321 cacctaaaat accagccatg taaatcccat tatcagacca aggaaccatc cccgaagtca 2284381 atgttccccc gacctctgag ttacgtgata acactcttct gtccagatgt aagcgatcat 2284441 agctgtcttc cataattttc ggagtcaaaa taagagatac atacatcgca cagccgaaga 2284501 tgtttgctaa aaacgctacg atcagtgtag acaatgtgac attgccggct gaagttaatt 2284561 tcttttcaaa cgttgaaaca atgactttta acacgccgag tttctcaagc agaccgccaa 2284621 aaccaaggcc aaagatgatg acgacgagag aatcaagcat accgacaatt ccaccgcggt 2284681 ttaacaagcc gttcaaaaat tcaacatccg ttttaataga gaagccgttg tacgcagttg 2284741 caatcgcatg ggcaatatcc attccttgga aaacaacagc ccagattgca ccgagtaaag 2284801 cgccaattac gataactggc atagatggct ttttcatcgc caataagact atgacgagaa 2284861 ctgccgggat cagcatccaa atatgaatgt caaacgtgtt ttgcaaagat gattttaaga 2284921 attcaacttt atcaagatca atatttttcc cgccgtacat aaatccaaca actgtaaaga 2284981 gtatagctgt aatgacataa gcaggtattg ataaataaag cattgctctc acgtgagcca 2285041 atacatcgac ttttgatagt gaagaagcta gaactgtact gtcagacagc ggagacagct 2285101 tgtccccaaa ataagcacct gaaagaatag ctcccgctac tagaggaagc ggaatgccta 2285161 acccctctcc aattgcgatc atggcaatgc cggcagttcc gactgttccc catgacgttc 2285221 ctgttgccac agacataatg gaacaaataa ttaacgttgc cagtaaaaag atacttgggt 2285281 gaataaattc cagtccgtaa taaatcaaag tcggcacaac gcctccggca atccatgttc 2285341 cgatgagcgc cccaactgaa acgagaatca gtacggcttc aaggccattt gatatcccat 2285401 gtacaatcgc attttgtaaa tctttataag aataaccgag tctaatacct aaaagcattg 2285461 caataaacca tgaaacaaaa agcgccagct gtatcggcaa gtcgagaaag actgtaaacg 2285521 atagaacaag tgctaaaaat actcctagta caataataat ttcaaatagt gttggcaatc 2285581 ttacatcctt caaaagaagt cccccttcat gtaaaagcta aaacgctttc aatatatagt 2285641 gcaacacgta tactatactt cctcatccct atgttgtaaa cagcttattc atccgactat 2285701 tcggagatga ataagctgta ttttatacaa attttatttt tctaatagtt ctttccctgc 2285761 gatacctggt ttggtcatct catatgggtt taaaataata tccaattctt cttcagtcag 2285821 cacatcatgc tgcagacaaa gatcccggac agattgccct gtcataattg cttccctggc 2285881 aattctagct gccgcttcat acccaagatg cggattgaca gctgtgatca cgcctgcgct 2285941 tttttctacg tattgcttca tacgcttttc gttggcttca atgcctttta agcagttgtc 2286001 agtgaacgaa cggaagccgt tgttcatgat gctgatggat tgaagcaaat taaagacaag 2286061 cacgggctcc atgacgttca actcaagctg gccggcttct gaagcaaggc agattgtatt 2286121 gtcatttccg ataacctgga acgcaatttg gttgatcagc tccgccataa ccggattgac 2286181 tttccccggc ataatagatg aacccggctg acgtgcaggc agagaaattt ccgcaagtcc 2286241 ggcgcgcggt cccgacgcca ttaagcgcag gtcgtttgcg atcttcgaca tgttcatcat 2286301 gcagactttt aatgaagctg atacctctgt ataggcatct gtattttgtg tcgcatcaac 2286361 aagatgatca gcgccgacaa gaggaagccc gctaatatca gcaaggtgct ttactacctg 2286421 tttgatatat tcaggatcag cgttcagccc tgtaccaaca gcagttgcgc ccatgttgac 2286481 ttcatacagg tgctggcgcg attgcttgat tcgtttgata tcacgctcga gaacacggct 2286541 gtaagcttcg aattcctggc caagacggat cggaaccgca tcttgaaggt gtgtccggcc 2286601 cattttaata acagagtcaa actcctgtgc tttttgctta aacacactat gcatatcttc 2286661 cattgttttc agcagttttt ctaagagctt caatgtggaa atatggatag cagtcgggaa 2286721 cacatcgttc gtagactgtg acatgttcac atgtgtgttt ggacttaaat ggatataatc 2286781 tcccttttta tgtcccatga tttcaagcgc ccggtttccg ataacctcat tcgcgttcat 2286841 gttcatagaa gttccggcac cgccctgaat cggatcgacg ataaactgat cgtgccactt 2286901 gccttccaga atctcgtcag cggcttgtac gatagcttgg ccaattcctt catacagccg 2286961 tttcacgtcc atgttggcaa gagccgcagc ttttttcaca atcgccagtg cgttaatcat 2287021 ttcctcatgg attttgtatc ctgtgatcgg aaaattttca gaagcacgga gcgtctgaat 2287081 tccgtaataa acatctgctt caatttgttt ttccccaagg aagtcttttt ccacgcgata 2287141 ttctttttgg ccgtttaaca taatctttaa ccttctttct ctttgctggt tatcgttttt 2287201 acattttaca ggacaacgtc atcagctatc ggcgtttcca taattctctt gacgacagga 2287261 agatccgaag actgacctag cgcccacatc aattttggca caattgcttc tgtgttcata 2287321 tttcttgatc ggataattaa gtcttggttg actctgcggc caacctcgta aatgctcatg 2287381 tcttcgcctt cttcaagaca ttgagtcgta atgacgacga caatgccgct ttcgatcagt 2287441 tcattcactt ttgacaaaat gtctctgcct tcaaacggca ctcctccgct gccataactc 2287501 tcaatgacaa ttcctttgta catgcttttc agggcatcaa acatttcggg ctttaagcct 2287561 ggatgcagct tcagcagaca tacatctgtg catagtgaag tgtcaactgt gaaggtgtcg 2287621 ttctcaggtt ccgttacttg tttgttgtat tcgatcccgt cttcattgat aaaagcgata 2287681 tatgggtaat tgatgctttc aaatgcgtcg tagcttttcg ttcttaattt gatcgcacgc 2287741 gttccctgaa tgactctgcc gtcaaacaca acataaacgc cgcccacgcc ttcacaggca 2287801 aatcgaatgg catctgtaat attttttttg gcatcggttt tttggaacgt gatcggaatc 2287861 tgcgagccgg tgatgacaat cggctttttg gcatgctgca gcatatacga tagtgcggca 2287921 gatgtatagg ccattgtatc tgtaccgtga gtaataacaa acccgtcata ggcatcataa 2287981 ttttccttaa cggcttctgc tatttccacc cagtattcag gctgcatatt ggtgctgtct 2288041 atattcataa gcgactgagt ttccattgtg taatcgttat caagttttga tacgtaactt 2288101 aataattcat cagccttgac tccgggagcc agcccatttt ccccttcaac tgaagcaatc 2288161 gttcccccag ttgtcaacat caataatttt ttcataccat gcacctcttc actgtatcta 2288221 aagatgggtt gcgagaaggt attcgctttt cgcatacttt taatgcaatt atagacacgg 2288281 aaaataaaat acgcaagaca ttattattca attcgcgtac acttcctaat acctatatga 2288341 tataatcagc tcaaggtgaa aaaggagcgg aagttcatga atctagatcg tttaactgaa 2288401 ttgagaaaaa agaaaaattg gtcgcttcaa tatacagctg accttctcgg tatcgcaaaa 2288461 agcacatatg ccggctacga gtcaggctac cgacggcctt cacttgaagc gcttgccatg 2288521 ctggctgacc tctttgacac aacctgcgat gaacttttag gccgcgagaa acaaaagcag 2288581 actgctcctc aggccataga attggccacg tggagcagcc tcgactttac catttctgtt 2288641 gatggccagc cgctgagtga agatgaaatc atccagctga ttacctttat acgcacaaaa 2288701 agaaaagtac aggaggaact gagttaatct ttagctcacg gtttaatttt accgtaggtt 2288761 cctcctcctc cggctttcaa ttccagtttt ccggatctcg cttttacgat aagcgccgcg 2288821 gttttcggcg ggacaacgcg agccaaatct tcttctgcag cctcatgaag aacagccatt 2288881 tctgttccga aggctttttt tagtttgtcc agcgttttcg ggcctacacc cggaacaaat 2288941 tgcagcggga tctgatgtac atatcgcgga cgcgggacgc gaacttcaag ctgatcactc 2289001 aattcacgca atctatcgct gactcccttg gtaaatctgg cttttccgca attcgcgcac 2289061 gctgtttccc cgcttacagc aggctctccg cacgcttcgc aagccgtctg ataatatttc 2289121 cccaataacg ggtccaagcc ataatttgcg ataattttcc tgtcatcttg tccctttaat 2289181 gcaagagcaa attcagtaaa atcagctgac tgcacatata attcattata ttctctgccg 2289241 attttcccca acgaatgcgc atcagaattt gttaaaaaag gatacggatt caattgcgat 2289301 acgtgtgatg ccatgtctgt atcacagctt aatccaagct ccaccgcgtc tatcatagat 2289361 ggatcaaaaa cctcagttaa gcttgattta accccttttc catataagct tttatgcggc 2289421 gtaaagatat gggcggggat aaacaggccg cccatatcct gcactttttt ttgcaggttt 2289481 aagcccgttt cataaatccg ctgcgagctt aaatgaatat ttttcagccg ggctgacagc 2289541 cagtttgaaa actgtttcat atcagccagc gtcggcataa atacgagcac atggatcggt 2289601 ccgctgcagg cttcatcata aatctccagc tcgctcccca ataaaagagt cgtgctgcga 2289661 taacggattc ctcccccgtc aagctcgcga tattttccag atgaaatgcc ttcctcaagc 2289721 tctagaatga cttccggaga atgacagtcg ataatgccga ggagttcaat tcctttatgt 2289781 tcactggctt caaccaaaat tctgtccagc gttaatgttt tggcgcctgt tattttgaca 2289841 gcccttcctg taaaggtccg gccgatatga atgtgcaaat ccgcgtaaat ctttttcatt 2289901 tttgtgcttg gagcgcttct ttcagctgaa gatactgaat cgcgtaggct gttttagcat 2289961 catatacttc acgcgattca accagcttta gcgcatcttc aagcgtcacc tccatcactt 2290021 caacaaactc gtcctcatca agctcccgtt tttcttcaag cacagaaagc tcctcagcaa 2290081 gaaaaacgtg aacgatttca tctgcaaatc cgggtgatgt ataaaacgca gttatttttg 2290141 tcagtttttt tgctgtataa ccggtttcct cttcaagttc ccgaagtgcc gtatactccg 2290201 gctcctcacc tttttcaagc ttaccggccg gaatttcaac gatcgtccgc tcaagcggct 2290261 tacggaattg tttgaccatg atgattttcc cttcatctgt gacggctagt accgctacag 2290321 ctccagggtg tttcacaatt tcacgtttac tggctttgcc gtttggcagc tctacatcct 2290381 cgacataaag atcaatgact ttacccgaaa aaatctgttc tttggcaatt gttttttctt 2290441 ctaatgattt catttcttca tctcccgttc tgtctctata tgatgcccca tacattttat 2290501 catactagag caaaaggggg cttcttcgtg aaagtgcacc gcatgccaaa aggtgttgtc 2290561 ttagtcggaa aagcatggga aattcgagcg aagttaaaag agtatggacg cacatttcaa 2290621 tatgtgaaag attggatctc aaagccataa aagttgaaac tttagctcct ttatattacg 2290681 gtcaatacaa agcctaaaaa aggagtgtgc acatgagaaa gcgcaaattg ggtacatctg 2290741 atttagacat tagcgaagtc ggactcggct gtatgtctct tggaactgaa aaaaacaaag 2290801 cattgtccat tctggatgaa gcgatcgagc ttggcatcaa ctatttggac acagcggatt 2290861 tgtatgaccg gggacgcaat gaagaaattg tcggtgatgc gatccaaaac agacgccatg 2290921 atattattct ggcaacaaaa gcgggaaacc gttgggatga cggaagcgag ggctggtatt 2290981 gggacccttc aaaagcttac ataaaagagg cggtaaaaaa gagccttaca cgtctgaaaa 2291041 cagattatat cgacctttat cagctccacg gcggcacgat agaggacaac attgatgaaa 2291101 cgattgaagc gtttgaggaa ttaaaacaag aaggtgtcat ccgctactac ggcatttctt 2291161 ccatccgccc gaatgtgatt aaagaatatg taaaaaaatc aaacatcgtc agcattatga 2291221 tgcaattcag cctgtttgac agacgccctg aggaatggct cccgctttta gaggaacatc 2291281 aaatcagcgt agtcgccaga ggtcctgttg ccaaagggct cttaactgaa aaaccgcttg 2291341 atcaagcttc agaaagtatg aaacaaaacg ggtacttgtc ctattcattc gaggaactga 2291401 caaatgcccg taaggcaatg gaggaagtgg ctcccgatct ttccatgaca gaaaagtcgc 2291461 tgcagtatct gctagcacag ccggctgtcg cttcagtgat tacaggcgcc agtaagattg 2291521 agcagttacg ggaaaatatt caggcagcaa atgcacggcg tttaaccgaa gaggaaatca 2291581 aagcgctcca atctcatacg aaacaagaca tttacaaagc tcatcgctca tagcagaaaa 2291641 accagcacct gtacgggtgc tggtttattt atattgatgc caatccattt ggctttcatt 2291701 taggagttct tcaaagctct tatttttttc gatctctttt ttctttctaa tctgttctgc 2291761 tttttctctt ttctgcctct tttcatcctc ttccttcaat tggctcttca tctccataag 2291821 ctttgctttg atatcggatt gaaggccgtc ttttagctgg tgtttgtcaa tggatttttg 2291881 ttttttcatg cagacttccc ccatgttttg ttttgaagcc agtttatcac ggagcatata 2291941 aactgaacaa gcagactctc ttctgatcac tttctcagcg tagcagtgtt taggtataat 2292001 gatcttaaac acgaattgcc tatatatttc gttgaaaggt gctgtgactt ttgaagaaaa 2292061 tccttttggc cattggcgcg ctcgtaacag ctgtcatcgc aatcggaatt gttttttcac 2292121 atatgattct attcatcaag aaaaaaacgg atgaagacat tatcaaaaga gagacagaca 2292181 acggacatga tgtgtttgaa tcatttgaac aaatggagaa aaccgctttt gtgataccct 2292241 ccgcttacgg gtacgacata aaaggatacc atgtcgcacc gcatgacaca ccaaatacca 2292301 tcatcatctg ccacggggtg acgatgaatg tactgaattc tcttaagtat atgcatttat 2292361 ttctagatct cggctggaat gtgctcattt atgaccatcg ccggcatggc caaagcggcg 2292421 gaaagacgac cagctacggg ttttacgaaa aggatgatct caataaggtt gtcagcttgc 2292481 tcaaaaacaa aacaaatcat cgcggattga tcggaattca tggtgagtcg atgggggccg 2292541 tgaccgccct gctttatgct ggtgcacact gcagcgatgg cgctgatttt tatattgccg 2292601 attgtccgtt cgcatgtttt gatgaacagc ttgcctatcg gctgagagcg gaatacaggc 2292661 tcccgtcttg gcccctgctt cctatcgccg acttcttttt gaagctgagg ggaggctatc 2292721 gcgcacgtga agtatctccg cttgctgtca ttgataaaat tgaaaagccg gtcctcttta 2292781 ttcacagtaa ggatgatgac tacattcctg tttcttcaac cgagcggctt tatgaaaaga 2292841 aacgcggtcc gaaagcgctg tacattgccg agaacggtga acacgccatg tcatatacca 2292901 aaaatcggca tacgtaccga aaaacagtgc aggagttttt agacaacatg aatgattcaa 2292961 cagaataaaa aagcgaaagg cctcttcggc tctttcgctt ttttatgtta cagaacgtcg 2293021 gtaatgccat ccatattttc tctgatccat tcaatcgcaa gatctatcgt tgtaaactcc 2293081 tgcgtctcga aggtcatttc atcctgcaat agccagacat ctttcttgat ggactctgct 2293141 cctccgattg accagtgaag caaggtataa ggatggtttt gattcaggaa ggatacccac 2293201 gttttatttt gtgctgtgtt cttcattgcc ttcagctttt gttccacgtt tcgcgtctcc 2293261 tactttacta atatgctcat tctggggctg agcatttcag ccgggctttt cagcgccaat 2293321 gttttggctt tttcattgta atcgatcgtc atttgatcgt caaaaaacac tttttgcgac 2293381 gattggatat acagcggaat gccgttcgtt tccagctgct cgcactgtcc cgttaattct 2293441 tctgccagcc agattgtcgg gacaccgctt accgcgcagc cgcatccttc tgcatcgtaa 2293501 cgaagctggg ctttttttcc cgggttggcg tcaaacgcct gctgcagtgc ctgttttgct 2293561 gcatctgtca catgtatgtt cataaggtga aacccccgtt ttcatcattt tcgctattgt 2293621 agcatacaat actgccattc gcattgtttc tgcctttttt ccaccgcttc gcattttctt 2293681 ctgcagtctt gatccactca tctttccctt gtatatactg attgatgctg tcagggtgct 2293741 gggccgccag ctgttttttg agaacggcgt attctttcgc tatgtttgga tgagctctga 2293801 gataatctct gaataacaga tgcctttcaa tagcagggtt tccctgttcg tacatatgga 2293861 catgatgagt gcgtttattt ccgccctttt ggaaataacg cctgcccgct ataccgttct 2293921 caccttttgg tgtatagccg ttggccttca tttgttcatc aaattggctc acggcttcaa 2293981 tgcttctgac ttcaattaac atatcaatga ttggcttcgc tgccatgtta ggtattgatg 2294041 tgcttccgat gtgatgaata gcgataatct ccggcccgaa cacaagtttc agccgttctt 2294101 tttcttcatc gaaacattct gcccattttt cgttgtagag aatgatctca acttttcttt 2294161 tcggatacaa atgaaagacc gacagcaata gaccctgcgc tgctttgacg gtttctgcct 2294221 tttggaatcc ggcctgtgta tagagtgaca cagccggggt attgttctcg gctgtgacta 2294281 cttcgatttt ctcagcgtct tcattatgat caatgacaaa ttgcagaagc gctcgtccaa 2294341 ttccttttct gaaaccgtca ggatgcacaa caagcctgca aatggtgaga taatgcatgt 2294401 ttttctcata tgaaatgaca ccgatcagct tgccgttttt ccgatatccc gcaaaccgtt 2294461 catgggatgc ttgaatatcc tttaccttct cttgtaaagc gggaataccg tcaaaaccga 2294521 taatctctgt ttcctttatg taggcgggga tctgtacggc taaaatctca cgcgctatag 2294581 tggcttcctt atgctggaga aattcaatca ttcgtgttct cctgaaacag ccgctgtctg 2294641 tcgacttttg cgacgcggac tgcatacgac tcgtaccaaa cgcttcttcc tttttctttt 2294701 gctgcttgat gttcagtgtg atgcctccaa tggttaattg cgtccatact gtcccaatag 2294761 gaaactgtga tgccccttcc atccgcttca cgtacgcttt ccacgcctaa aaatccaggc 2294821 tgatccgccg caagtgatac catccgctcc gctgtttctc catatcctgt gtcattttcg 2294881 cttttgacag aagaaaaaat gactgcatag taaggaggct caggtgtttt tgataaaaaa 2294941 tccatcatat ttccccctca tatgtttttg acaaatagta ccctgtcttg gcccgggcca 2295001 tcatagtttg caaacactga gatgccattt accgttttgg tgcccttttc aatatcaaac 2295061 cccaattttg tgtgatatgc gattgatacc ttattcacag gtgaagtgac acacttcacc 2295121 cgggtgcagc ccctttgttt tactgtttcg ataaatacat catacaattg tttcccaatt 2295181 tgcatttttc tgaaatccgg atgcacaccg gaaaaatgaa tgtacgccgt ttcaggatcg 2295241 gattgcgatt gaaatccgat taaaaatccc gtcatgctgt tatgttcgga tgtaataaag 2295301 cttgtgtcct gaaaatgctc aaaaaatagt ctcggcaatt tttctttcag ctgtctgccg 2295361 ccccaccatt cattcagtac agacgttacc atttcataat ctgaagacgt gattgttcga 2295421 atatccatta cgatttgatc tccctccgtc tggcaaaacg aatgtcagct ctttttctca 2295481 caatataaaa attatatttt gcctggctgg aattgtaaat gccttctttc ctgtatcata 2295541 cgtttccaga ctgccgaggg aacaatgttt gatcatttta cgcctatttc tcccccaaac 2295601 aggaggagag actttacagc acaatatcaa gcacttgatc aagtttcagc ttataaagct 2295661 gatcctcgtc tccttttatc catactgctt tttcaaactc ttcataccgg cagattttcc 2295721 cggtgcagca gacaatctca ccgtcctgaa agcagctgac agtgatatcc tgagcaaact 2295781 ccatcgcggc gcaaagcgtt tgattcatct cttccagctt atcggggtca aggatcggct 2295841 tttgcagctt ctgtttaagt cgctttctct ccagcaggct ttgcttatgt tccggcagaa 2295901 acatcctgct cccttcccac agcaggttgc ccctttttaa atggtcgttc atttataatg 2295961 cccccctatt ttagccgcac gttcaaatgc ctggcctgcc gctgtcagtg acgccgccct 2296021 gatgattgct gtatcgccga atcgattttt aatgccatcc atcacatagc ctaggctcat 2296081 tttctttgca taatcctgaa ataaattgag ctgccatatg tcatcagatg agagctgaga 2296141 cagattgaca ccgaggcggc ggacgggttt cccgtcccaa aatgtaagaa acagccgtcg 2296201 tacagcctca tatacatcct gcgtagaatt agtcggctct gccagcttca cttgccggtt 2296261 gaagcccgtc ggccaatcaa aatcagcacc ccggcagctc actgacactg tctgccccat 2296321 gaccccggcg tttcggcttc gcctgcacac ctcttcactc agctcaagca atacgacctt 2296381 gatttctttg tcaaagtgtt cgtagtctct cgggagagtc attccatgac ctatcgcctt 2296441 ttgcccgtcc agagacgaag ttgacacagg ggaatagtcg attccgtttg ccgtcatcca 2296501 cagcacgtgg ccgttaatgc cccatttctt ttttaaaaga tcgagcggaa aagccgcgag 2296561 cccgccgatc gtgctgatgc ccattcgatt taaatgatgc ttcatgcggc tcccgacgcc 2296621 aaacatgctg cccaccggga gcggccacat ttcggttttc atattttctt tcgttaaggt 2296681 aaaaataccg ttcttattct ttttggcaaa attgtcacac gcaattttgg ccagcgcttt 2296741 gttagggccg attccgaccc gtgcataaac gccgatctcc cgcatgattc tgccctgaat 2296801 gcttttcgcg atctccatcg gcgtcccaaa cagcttctgg ctgcctgtaa tgtccatgaa 2296861 ctgttcatcg atggaatacg gctccacaag gtctgtatac tcctcgagaa tggccgtaat 2296921 ttgcagtgat acatcaatat accgctgcat acgcggccgg agcacaacag cctcaggaca 2296981 cttttcctgc gcctcccaca gccgtgaagc attcaccaca cccttttgtt tcgccagcgg 2297041 gcaggcagcc aatacgactc cgcccctttt ttcagggtca cccgaaacaa tgacgggcct 2297101 atttttcaaa tgtggatttt ccgctttctc tacagatgca taaaacgatt gcatgtcaac 2297161 gagaaaaatc actttttctt tcatcataca cacctctaaa aagaacttat gttcgctttt 2297221 cattatatgc gaaagtatgt tcgttttata ctggtaaatg attcttgtct gacagaaaat 2297281 atgatccaag ggtttgagag aagaaaaaca tttagtagaa taaaagcgaa gcataaggat 2297341 aggagagtca tgatggagaa atttgtcgaa aaaatgctgg gacaggcatt gcggcaatac 2297401 ggcagaaacg ttgctataga tccgttaagc ccgtatgaaa aacaaagcct gaaagcggct 2297461 ctacaagaga gacggaatga agaaccagat gaggatttgc atgcgcatat agaagatatc 2297521 atttatgact atgtcacaaa ccaaggcctg ttctcttaaa cgcatgactg tcagttcttt 2297581 cagccgctga tgcggcttcc ctttgaaaac accgcctgaa acaaataaac agtctcaggc 2297641 ttacagaaaa aaagcaggat tttctcacgc tccatagatt catatggcct ggcgtaaaat 2297701 tcccctcaat gctcgcgcaa aacggaataa gctgtccatg atcacgcgta tacacttttt 2297761 cgaagagatg tgctctcttg ttctgtcatg cggtccatgc cggttttcag cgtacatctt 2297821 gatctcatag ccggtttcac tgccgatatg atccacgttc tggcggctta aactaacaca 2297881 ccctcactga ccaatcgctt tgcttttcat cggacatccc gtcattttcc ttctttcaag 2297941 atgtaaactc cgtcagccac acgcatcctc aacgcatagt atattgccat ccatacaatc 2298001 aggcatacta catgtcaata acgaaatatt ttgaacgatc tattggagaa ggaaattttt 2298061 tcatatatga tagagaaaga tcatacatac aggagagaat ataattcatg aagaaatgga 2298121 aagatatcca cccgatcagc tggacaatta taatcggaac cattttcggc agaatggcaa 2298181 catcgatgag cattcctttt ttagcgattt atttgacagc cgtccaaggc gcatcagctt 2298241 cctatgcagg gctggtcatc gccgcgagct catcagtcgg catcctcgca agcttttacg 2298301 gcggatatat ctcagataaa ttcggcagaa aaaacatgat gcttgtatcg attttcggat 2298361 ggatgctggt atttgcaggc tttgcggcag catctaatct ctgggtgttt tttgtagtaa 2298421 acgcattaaa cggtctttgc aaatcactgt ttgagcccgc ttcaaaggcc ttgttgtctg 2298481 atatgacaga agaaaaaacg agactgctag tttttaattt acgctatgcg gctattaata 2298541 tcggcgttgt cttcggacct gtgcttggcc tatatttcgg ctcatcgcaa tcgactacgc 2298601 cctttttggt gcctgcagtc atttacggac tatacggaat tgtgcttgcc ctccaattta 2298661 aaaaacatcc atccttatca gcaccagccc agtcccgaaa tatgagcgtg cgggaagcgt 2298721 ttatggtcac gcaaaaggat tatcttttta ccattgcttt ggtcggcatt acgctatgca 2298781 ccttcggcta ctcacaattc agttccacat tccctcagta tatggcgcag aaccccttga 2298841 tcggcaatgg aacgaagctg tatgggctga tgctgacatt aaacgcaatc gttgtgttgg 2298901 cgacgcaatt tcccattgtc cattttgcaa aacggttttc gccgctttgt tctctgatgc 2298961 tcggtaatgt gatggttagc atcagcatgg ccattttcac cgtatcacac ggtgttccat 2299021 caattgtgat gattgtcatc acatttacaa tcggcgaagt gcttttattc tctatgatgg 2299081 atttgtatgt agaccagatt gcaaaaccag gattaaaagg cacttatttc ggggcaatcg 2299141 gtttttcaca gctcggaaac gtcatcggcc cttgggtcgg ggggatatgt atagacctgt 2299201 ttggcgctgg ccggccgatt tatatttttt ctgtcctgag cggcattacc ctgctcggcc 2299261 tgccattttt agcgttcgcc tatcggcaaa tgaaaatgga gaccacaaaa caccgttccc 2299321 gtctggaaaa gccgctttaa ataaaaaacg gaagagaatg aatctctccc gcaaacatga 2299381 ggtgaagaac atgaatatag gtgatgtgat gtttcagctg tttgtattta ttatatttgc 2299441 cgctgtcgtc tttgcggctg ttacaggctt caagtatgcg aaaaaccgaa aagcgcagct 2299501 ggatcgcatt gagaaaaagc tgaacagcct gtccgaagat cacgattaac agcttggggc 2299561 aacgagctct accttaatcc ggtctggatc ctcacaaaag actgcataat gcccgtctcc 2299621 tccggcaaaa ggatgcctgt ctcggtacaa cacacgatag ccttttgccg tcaatttttc 2299681 agtcatctga tcgacttgaa gcttggattc agcatgaaat gcgagatggt tcagaccgac 2299741 tcggcatcta tggtattccg gctctagaaa tggctctttc gcctgcacaa tcactaggta 2299801 aaaacgatct ttcttccagc tgatgcctga gctccatttt tgatactctt tataaccaag 2299861 ttcttttaag aaccagcccc aaaaccgcct agacgcctcc aaatcagaga catacagttc 2299921 aatatgatgc acatttcata ccctccttac caacacttcc tcgaccttat gcccgtctcc 2299981 cttacgcaaa atgagatctg acctgaattt agttggcaaa atattttcat ataaattcgg 2300041 ccggttgaca ctctcccaaa tcgaggctgc catctcgtca gcctcctgat cggacaagtc 2300101 tttaaattta tgaaaatatg aatcaggatt ttgaaaagct gtttcccgaa gcaggcgaaa 2300161 acgctctaaa taccaagtga aaatccggct ttcctccgca tccacataaa tcgaaaaatc 2300221 aaagaaatcg gaaacaaaaa tacgcgggtt ttcccggtca tcctccaagg tgggcgactg 2300281 aagaacatta atgccttcaa taatcacaat atccgcctgt tctacaacct cgaacacacc 2300341 ttcctcgcgg tcataggtta gatgggaata caccggggcc tttacgctgt cctttcctga 2300401 ttttaagtca ttcaaaaatt cgagcagcgc ctttacatca tagctttcag gaaatccttt 2300461 tcttgacatc atatttttct ttttcagctc ggcagtagga aataaaaaac catctgtcgt 2300521 gataaggctc acttttggac ggtcaggcaa acgcgaaagc agcttctgca agatccgcgc 2300581 cgtcgtgctt tttccgactg cgacactgcc ggcaatgccg ataataaacg gaattttggc 2300641 tgaatgtggg tgcttcaaaa aaacattgac atgcttattg cgttcagccg cagacttgac 2300701 atgtaaatga agcaagcgaa caagcggaat atagatcgtc tccacttctt caacagatag 2300761 ataatcattc aatccttcca cagcttttgc ctcttcttca gatacagcaa tcgacaaatg 2300821 ccccccaaaa ccagaccaag actcccgatt gtgctgtgta tataaagtat gtaggttaag 2300881 ttctttattt ttcactgttt acacctgact ctctgtaggt taaaaccctt acaaagattg 2300941 taacggaaaa ccttttcact gtctgcttat ttttcatttc gtttttttag caaatcagca 2301001 ccgattcggt tatacgcagc catttcatct tttggaacca tgcttcctcc cgttccccag 2301061 acgacatgta cggcatgttc catcttatat ttctgagcat agcgccttcc ctcttctgtc 2301121 gaaaaaagct gaaccggccc gaacatgcca gcaagagcag agggctctaa atatttatct 2301181 tcagatacag ccagcatatg aagcaaagta taaagcgtat tgtcctctac cgtataacag 2301241 ccgctcagaa gcggttcaat cagcttgccg acaaatcctg acggcctccc tacggcaagt 2301301 ccgtcagcag ccgtctgatt atccaggccg atatcctgga cggagatctt ctcgtgaagt 2301361 cctgaataaa gccctaacag catacaaggt gaatgagttg gttctgcgaa aaacacatga 2301421 acatcatctc cgtataaaag cttcagccca aatgctacac cgcccggtcc tccgccgact 2301481 ccgcacggca gatacacaaa caagggcgtc tcaagacttg gctttatatt catacagtca 2301541 agctgtgttt ttaatcggct tgcagcaaca gcatatccta agaacagctg acgagaatgt 2301601 tcatcatcaa taaaataaca gaatggatct tgttccgcct gccgtctccc ttcgttcacc 2301661 gcttcactgt aatctgtttc gtactccata acagtgactc ccttttggcg gaggagatcc 2301721 tttttccact gcttagcatc ggcggacata tgcactgtca cgcgaaaccc gagtgccgcg 2301781 ccgatgatgc cgatgcttaa acctagattt cctgtcgaac cgacagcaat cgaatagcgg 2301841 gagaaaaacc cggtaaaccg ctcttcctgt aagatgcggt aatcatcggt ttcctgaagc 2301901 attccttctt gaagcgcgag attttcagca tactttaaca cttcataaat cccgcccctc 2301961 gctttaatcg atcctgaaat cggaagctca tggtcgcact ttaaaagcca tcttccggga 2302021 aatggctgct gatatgccgc ttccagcttt cccttcatat gctgcacctc aaaaagcgga 2302081 gactcgatga ttcctttagc gcctttcgtc tcaggaaaca cctcggcaat gtaaggtgca 2302141 aaccgctgca ttcttttttc cgcttccgct atctcggttg cccactcatc tgcacggggt 2302201 aatggcccct ctttcttgcc tgaatttgcc cagaatacag gctctgcatc aatcagtttc 2302261 tgaataaacg gatctttaag cagagcatga aggacttctg aatgaactga cattcaacaa 2302321 tctctccctt ccactatcaa aaactgcccc gtgagaaaca agccactcca ccacaggcag 2302381 ttctatcatt attttttcat gagcgcgcgt cctgccagct tttctacaag agctggaaac 2302441 agctgataca gcttagtgcc ggcattcatt aaacgcggaa gattgatctc ccgctttttc 2302501 gtaaaaattg cagctgtaat ttgagctgcc acgtcatcag gatcaagcat ccagcggccg 2302561 acatttttgg cgtagtcccc gcctttatca gcaatggaaa aaaagtccgt ctgaatcggg 2302621 cccgggttga ctgttgtcac ataaatgccg gttcccgaaa gctccatccg caaagcgttt 2302681 gagtaaccta acacggcatg tttggtcgcg gaatacaggc tagacttcgg tgtggcgatt 2302741 ttccccgctt gagaggcgat attgatgata tgtccctttt tttgctcaag catttgcgga 2302801 agcaccgctt ttgtacaggc gatcaggccg aagacattca catcaaacat cgctttcatg 2302861 tcatccaatg tagagtctaa aaccgtttca aatataccga agcctgcatt gttaatcagt 2302921 acatcaatcg agccgatctg atcgcggacc cgggcgatat cctctaggcg gccgacatcc 2302981 agaggaaaaa tctcacactg tccgctccat tcctcggtta ttttcctttt gatttctatc 2303041 aaacgatcct cgcgtctagc cgacagcagg acatgggctc cttcagccgc gcataagtat 2303101 gcgattcttt ctccaagccc tcctgaagcg ccggttatcc aaatcctttt tcccgctata 2303161 tgtttcaccc atttcacctc ttcattgttt taaagtatac ggtatttcct tcccaatatg 2303221 acgtgatggc ttcttcagcc tccaacacat caaggtgacc tgccgtttct gacatcgtta 2303281 aaaacaattc cttttcatat acagcaggaa aaagctgctg acagacctga aaagcggtca 2303341 tcggcttttc atccagcatg cgacgcacat cctccgtcct gttcctctgc ttgtcaaaac 2303401 gcttctcaat cagcgcttgt acactggtga taggctcgcc gtgaccagga aatacgattg 2303461 ttggatcaag ttgagacagc cttcgcaatg accgctgata atccactaaa ggctttgacc 2303521 tgacgtctcc cgctttcggc gcttccaaaa tcggattaga cgagctgttt gccagcagta 2303581 gatcgccgcc aagcatcctt ccgctttttt catggaacag aacaatatgc gattcagcat 2303641 gtccaggcat ctccaacaca gaccagccct caagcccatc tatgcccata ccttctctga 2303701 ttgattttgt cagagatctc gtacaggaaa atgcgtacgc tgatcgaatc agcttttccg 2303761 ccttccccgt atcaaatgga acgcctaatt caggcagcag cttttgaaaa aaacgttttt 2303821 gccaatccat aaaggcttga ttttggctga tataaggttc gttgaatgta tgcccaatca 2303881 cttcgatttc atctgaaaag acatcaagca agcctgcatg atcagcatga tggtgagtca 2303941 gtacaacctg ctcgatatct gacaatttca catttacagc ggcaagctgc tcttgtaagg 2304001 ctctggcagc ctcttttgta ttcggcccgg catcgataag tgtcagcgca tcacctttta 2304061 cgaggtaaac gataacatcg ccgacagcaa acggtgtcgg gacgcggatc gcaattacat 2304121 cttcagttgt catcctttcg ctccttgtct tcattcatta ttcatatttt agctttttct 2304181 cggtcttgtg tcattattgc agaatgagaa caaacctttt tgaaaaagct attgacatta 2304241 gcttgtccgc cattgcataa tgaacaacaa actaaaacga gaaccattgg aacgctatga 2304301 cgaggaatag tatacaaggc aatggcctaa gagagcgata cccccggctg aaaggtgttg 2304361 cggcccgctt gtttgtagaa cctgccctca agtcgcggtt aggaaaacct aaacgtttcc 2304421 cgcgttacgg ggatttgagc tgagcacaat ttgtgctaat gagggtggta ccgcgaacct 2304481 tttcgtcctt tacgtgatga aaaggttttt tgttgttcta atagaaggag gatatcaatg 2304541 aaaaagatag gatttgtcgg cgccgggtca atggcagaag caatgatcaa cggcattttg 2304601 caaagcggca tcacaaaacc agaacatatc tatattacaa atcgctcaaa tgacgagcgt 2304661 ctgattgaat taaaggaaac gtacagcgtg cgtccatgca gagataaaaa tgagtttttc 2304721 actcacaccg atatcattat cctcgctttc aaaccgaaag acgcggcgga aagcatcgac 2304781 agcatccggc cgtatatcaa ggaccagctt gtcatttcag tacttgcagg ccttaccatc 2304841 gaaaccattc agcattattt tggcagaaag ctcgcggtca ttcgcgtcat gcctaataca 2304901 tcagcggcaa tcagaaaatc agcaaccgga ttttccgtaa gcacggaagc aagcaagaat 2304961 gatattattg ccgcaaaagc tctattggaa acaatcggtg atgcaacact ggttgaggag 2305021 cggcatcttg acgctgtcac tgcaatcgca ggcagcggcc cggcctatgt gtatcgttat 2305081 attgaggcga tggaaaaagc agcacaaaaa gtaggattag ataaagaaac ggcaaaagca 2305141 ctcattttgc agacaatggc aggggcaaca gatatgctcc tccaaagcgg caaacagccg 2305201 gaaaagctgc gtaaagaaat caccagtcct gggggcacta cagaggcagg tcttcgcgct 2305261 ttacaggact cccgctttga agaagcaatt attcactgta ttgaagaaac agctaaacgg 2305321 agcgcagaaa tcaaagaaca gtttgccggt gccgccttag agagacattc ttagatgtaa 2305381 ggacaaaaac agaaggcaca gtgccttctg ttttttattt ttcccgcagc agctggccgg 2305441 cagattctga ttgctttaat agcgcggaga tcgtaaatga aagcaaatcg ggaagcactt 2305501 caaaggaata aggcatatac aatctttccg tccatttatg cgggtcttta ccagccggac 2305561 cgacatttaa aactgggaca tataaagcct gatttttacc gcttggcaat gaataccctc 2305621 tgttaaagag cggcatattg cttgtgtatg catcaacctc ctgtttttcc agctgaagat 2305681 aactcaagtc cgaaagtccg gggaagtact gaacctcccg taatgcaatg ccgtatcgct 2305741 cagccgcata atgctttatc tgatctgctg tatttctgat caattgatca tcctttgaag 2305801 aaacagctgg ataaagcggc ggactataaa acagaacgat gagcggcgca tcctccttac 2305861 aaagcgaagc aagctcagaa acaattttcg tcgaaaaatc cctgtctcca agctcccccc 2305921 tgttagcaaa ggcataattt agagcccgct ctgtttccga gatccccgca cgcttttttg 2305981 cacgcgagac cagctcatca aatgtcaaaa cagtgacgtc ccgctcaatc ggctgaaatg 2306041 gctcaaattg ttgaaaatcc tgtgttttct tccgaacgtt cgacatgatt tcctccgccg 2306101 cctgttctgc tgttttaagc agcatctgat gcagctcact agctgagcgt ttcattgaca 2306161 gcacattaaa taatgtgacg gctgtatgcg gtgtctggac tgaatatgcc tctttcaagt 2306221 ccttttgcat taagtttacc ggcggcggag tgacctcgcc atcaaccttt tcgcaataat 2306281 cagcattcag ttcaagcaaa cggttaatct cagataccat taaatttgcg tttagacctg 2306341 aaaacggctc tccaacatgt gtctcaatcc ccttgcagaa aaaacccgca agcaccttgc 2306401 caatgcttcc tgtataaaaa tattgctgct gatcgccggg aaatttttca aacatcggtt 2306461 cggcattcag gcaagcggtt aatgtgatat catgcttttt ctccatctcc ttcaatgcag 2306521 gaaccgcttc aatcatgcct cttgaattca cttcctcgtc cggaaccgtt atcaacagca 2306581 gattgccctc aaaatgcccg ttcattgccc tctccagcat cgacagttga atacaaagcc 2306641 ccgctttcat atccatcgtc cctcttccga acagccagtc tccgctttcg gcatctcttc 2306701 tcacacgttc cgggagcagc tcttttttct ctaaaaagga gctcaaaagc tcagcaggct 2306761 tgcaagccat atgtttaaat tcgccgtaat cttctatgtc aacgacatca aaatgactca 2306821 gcagaagcac tgtctttttg acattcttct ttttgactag agccgtaaga aaagatctgc 2306881 catcgtccat cggatgaagt gttacatcat cagggtgctt ttgaaaatag ggcttgtcct 2306941 tcaaaataaa ataaagatac tctgcaagcg ctacctcgcc ctttgaaccg gtgatgcttt 2307001 cgtattgcac aagagaagtt aaaagtgcca gcaattcgtc cttcgtctgc caattcattg 2307061 attccgcccc tcctatgaat aaaaatgctt ctatactgaa aaataaactg atttctcgtc 2307121 tattatacag aaatgtttga caaaagcggt tcatttgagc agtttatatg acgggaaaga 2307181 aatgacttga tataatcaat ctctaaaaac cttacgggag gcgaaagaaa tggccagaaa 2307241 attatttaca cctattacaa ttaaagatat gacgttaaaa aaccgcattg tcatgtcgcc 2307301 aatgtgcatg tattcttctc atgaaaagga cggaaaatta acaccgttcc acatggcaca 2307361 ttacatatcg cgcgcaatcg gccaggtcgg actgattatt gtagaggcgt cagcggttaa 2307421 ccctcaagga cgaatcactg accaagactt aggcatttgg agcgacgagc atattgaagg 2307481 ctttgcaaaa ctgactgagc aggtcaaaga acaaggttca aaaatcggca ttcagcttgc 2307541 ccatgccgga cgtaaagctg agcttgaagg agatatcttc gctccatcgg cgattgcgtt 2307601 tgacgaacaa tcagcaacac ctgtagaaat gtcagcagaa aaagtaaaag aaacggtcca 2307661 ggagttcaag caagcggctg cccgcgcaaa agaagccggc tttgatgtga ttgaaattca 2307721 tgcggcgcac ggatatttaa ttcatgaatt tttgtctccg ctttccaacc atcgaacaga 2307781 tgaatatggc ggctcacctg aaaaccgcta tcgtttcttg agagagatca ttgatgaagt 2307841 caaacaagta tgggacggtc ctttatttgt ccgtgtatct gcttctgact acactgataa 2307901 aggcttagac attgccgatc acatcggttt tgcaaaatgg atgaaggagc agggtgttga 2307961 cttaattgac tgcagctcag gcgcccttgt tcacgcagac attaacgtat tccctggcta 2308021 tcaggtcagc ttcgctgaga aaatccgtga acaggcggac atggctactg gtgccgtcgg 2308081 catgattaca gacggttcaa tggctgaaga aattctgcaa aacggacgtg ccgacctcat 2308141 ctttatcggc agagagcttt tgcgggatcc attttttgca agaactgctg cgaaacagct 2308201 caatacagag attccggccc ctgttcaata cgaaagaggc tggtaatgcc cataagagat 2308261 atcctgtaga ggatatctct ttttttattt ttagagaaac gatcggctaa ggttctccgt 2308321 ctccctagta gaaccaatta gaggagatga ctccaatgaa atcagcttgg atggaaaaga 2308381 catatacaat tgacggatgt gcgtttcata cacagcaccg gaaaggatca agcggtgtaa 2308441 cgattgtctt tgaggccggc tatggtactt cttctgagac gtggaaacca ttaatggcgg 2308501 acattgatga tgaatttggc attttcacat atgatcgggc aggcatagga aaaagcgggc 2308561 aaagcagagc taaacgaaca gctgatcaac aagtgaaaga attggagagt ttgcttaaag 2308621 cagctgatgt aaaacctcct tatttggctg tttcacactc atacggagct gtcatcaccg 2308681 gtttatgggc ctgcaaaaac aagcatgata ttatcggcat ggtccttctt gacccagctt 2308741 taggcgattg cgccagcttt acctttatac ccgaagaaat gcacaaatca catacgagaa 2308801 agatgatgct tgagggcaca catgcagagt tttcaaaaag tctgcaggag ctcaaaaagc 2308861 ggcaagtcca cttaggaaac atgcctcttc ttgtgttgtc atcaggagaa cggactgaga 2308921 aattcgctgc tgaacaggag tggcaaaact tgcacagcag catattgtct ctatctaacc 2308981 aaagcggctg gattcaagct aaaaacagct cccacaacat ccatcatgat gaacctcata 2309041 tcgttcactt ggctatttat gacgtatggt gcgcagcgtg ccagcaggcc gctcctcttt 2309101 accaggcagt caattaacgt aaaaaaagac cgggccgtaa gggattcccg gtcttttata 2309161 ttattttgtt tcacggtgaa gggtatattt ctttaaacgc ggtgaatatt ttttcagctc 2309221 caaacggtct ggattggtgc gtttattttt tgttgtgatg taatttcggt ctcccgtttc 2309281 agtgcaaagc taaagtaaca tttactctca taattaacat ctccttataa aacgtaatga 2309341 ttacgtttta ttatacaacg tcatcacaaa ttgtcaaata agagctccgc cttcagcctc 2309401 gcgggacgtt tacctctaag aaatcatatg ccgccacgct attggggaaa acgtcaaccg 2309461 cttctttttg aagctccaaa gaagcatctc cctgatatct tgcgctgata tgggttaaaa 2309521 tgagctgctt cgctcttgct tctttcgctg ttacagccgc ttgttccgtt gtactgtgat 2309581 aataatcata agcaagttta cggtcttcct tagcaaaggt tgcttcatga acaagcacat 2309641 cacaatccct cgcaagctct tttagtttgt cacttactct cgtatcaccg gagaacacaa 2309701 cagatcttcc ctttttagga ggctccagaa aatcattccc attgatgatt cgtccgtctt 2309761 caagcgttac cgtttcgcct tttttgattt tctgatatac aggtccgggc gggatgttca 2309821 tttcttttaa tacgtcagcc ttcaaggaac ccggtacgtc tttttcctgc acacggtacc 2309881 cgaaggcttc cactccatga ataacagata ccgctgtgac aataaactga tcgtcctcaa 2309941 acacgattcc ttcttcaatt tcctggatcg caagcggata tgtcaaatgg gttttcgtga 2310001 cggcaaggct tgtttcaata aacgccttga tccctttagg tccgtacact gtcagctcgt 2310061 cctctccgcc ttgaaaggaa cggctcccca gaagccccgg aagtccgtat acatgatcgc 2310121 cgtgcatgtg tgtaataaag attttctcta ttttacgagg tttaatcgtt gtatgtaaaa 2310181 tttgatgctg tgtggcttcc ccgcagtcaa aaagccatac cgaacgcctt tcttcaagca 2310241 attttaatgc caccgacgtt acatttctcg ccttggcggg gatgccggct cccgtcccta 2310301 aaaaaagtaa ttccacgttt ccttcctcct actagaacca gatacctaca agaatacagg 2310361 atcaagcgga aaatgtgaat cttgcctctg aaaagaacaa tcctttcgtg ctagaaacat 2310421 tttttcagca ttctgcttaa aaaagggctt aaatgtttgc tttcgttgaa ttttagattt 2310481 aaaatgaagg aaatatacgg ggtgtactaa aataaagctt cgaataaagt gaggtacttt 2310541 tagtgaaaac aaaccaacaa ccaaaagcag taattgtcat attcggtgca actggagatt 2310601 tagcaaaacg aaaattgtat ccgtctattc accgtttata tcaaaacgga caaatcggag 2310661 aagagtttgc agtggtagga gttggaagaa gaccttggtc taatgaggat cttcgccaaa 2310721 ctgttaaaac atccatttcc tcatctgcag ataagcatat agatgatttc acgtctcatt 2310781 tttactatca cccgtttgac gtgacaaacc ctggttctta tcaagagcta aacgtattgc 2310841 ttaaccagct ggaagataca tatcaaattc ctaacaacag aatgttctac ttggcaatgg 2310901 ctcctgaatt cttcggaacg attgcaaaaa cattaaaatc agagggtgta acagctacaa 2310961 ccggctggtc ccgccttgtc atcgaaaaac cgttcggcca tgatctgcca agcgcacagg 2311021 cattgaataa agaaatccgc gaagcattta cggaagatca aatttacaga atcgaccatt 2311081 atctaggcaa acaaatggtt cagaacattg aagtgattcg atttgccaat gcgattttcg 2311141 aaccgctttg gacaaaccgc tacatttcaa acattcaaat cacatctagc gaatcactag 2311201 gcgttgaaga ccgcgcaaga tattacgaaa aatcaggcgc ccttcgcgac atggtgcaaa 2311261 accatattat gcagatggtt gcccttcttg caatggagcc gcctatcaaa ttgaacacag 2311321 aagaaatccg cagcgagaaa gtgaaggtgc tgagagcact gcgtcctatt gcaaaagacg 2311381 aagtggatga atactttgtg cgcggacaat atcatgctgg tgaaattgac ggtgtaccgg 2311441 ttcctgctta tacagatgaa gataatgtcg ctcctgactc caatacagaa acctttgttg 2311501 ccggcaagct cttgatcgac aacttcagat gggctggtgt tccattctac atcagaaccg 2311561 gaaaacgaat gaaagaaaag tccacaaaaa ttgtcgttca atttaaggac attccgatga 2311621 acctgtacta cggtaatgaa aacaacatga atccgaactt gcttgtcatt catattcagc 2311681 ctgacgaagg cattacgctt tacttaaatg ctaaaaagct tggcggagca gcacacgcac 2311741 agccaatcaa actcgattat tgcagcaatt gcaatgacga gttgaacacc cctgaagcat 2311801 atgaaaaact aattcacgac tgtcttcttg gcgatgcaac aaactttgca cactgggatg 2311861 aagttgccct ttcttggagc tttgtcgact ctatttctga aacatgggca gcaaacaaaa 2311921 ccttatctcc taactacgaa tcaggctcaa tgggaccgaa agaatctgat gatcttttgg 2311981 tgaaagacgg cttacactgg tggaacatat aataagaaga aaaaagccga aatagtttac 2312041 taagcatttt cggtcttttt tacgctgaac aaaggtataa caatctcctt aataacaaaa 2312101 cccccaaagc ttaagagctt cgggggtttc tattgattac ttcatccatt cagtatggaa 2312161 gatgccttct ttgtcagtac gctcataagt atgagcgcca aagtagtcgc gctgtgcttg 2312221 gattaagttt gcaggcagta cggctgtgcg gtagctgtca tagtaggcta atgcgcttga 2312281 gaatgatggc accggcacac cttgggcaac tgcaagtgaa atcacttggc gaagcgctcc 2312341 ttgatagctt tctacaatat tcttgaaata gctgtcaaga agcaggttgt caagctcagg 2312401 ctcgcgatcg taagcttctt tgatcttctg aaggaatgcc gcgcgaatga tgcaaccacc 2312461 gcggaagatc atagcgattt caccatattt cagatcccag ttgtattctt cagaagcagc 2312521 tttcatttgg gcaaatcctt gcgcgtatga acagatttta ctcatgaaca acgcttttct 2312581 gaccgcttca atcagctctt ctttattttc tgtaacaggc ttcacttctg gtcctgaaag 2312641 aagtccgctc gcttttacac gctcttcctt catagctgag ataaagcgtg cgaatacaga 2312701 ttcagtaata atcggaagcg gaacgcctaa gtcaagtgcg ctttggcttg tccattttcc 2312761 tgttcctttt tggcctgctt tatcaagaat cacatcaaca agcggtttgc ctgtttcttc 2312821 gtcttttttt gtgaagatgt cagccgtaat ctcaatcagg tagctatcaa gctcaccttt 2312881 attccattca gcgaaaactt catgaagctc atcagcagaa aggcccagca cctgtttcag 2312941 aatgaaatat gattcagaga tcagctgcat atctccgtat tcaattccgt tgtgcaccat 2313001 ttttacgtaa tggccggcgc cgtccggacc gatatatgtc gtacaaggtt ctccgtcaac 2313061 ttttgcagaa atggcttcaa gaatcggttt tacaagctca tgtgcttctt tttgtccgcc 2313121 aggcatgata gaaggtcctt taagcgctcc ttcttctccg ccggaaacgc ctgttccgat 2313181 aaaatgaatg ccgctttcag cgagttcttt gttacggcgc tgtgtatctt tatagtatgt 2313241 attaccgccg tcaattaaaa tatcatcctt ctctagatga ggaagaagag attgaattgt 2313301 cgcatctgtt gcagttcccg ctttaaccat taataagatt ttgcgcggtg tttccaagga 2313361 ttggacaaat tcttcaatgc tgtaagtgcc aacaacattt tttccttttg cctcctgtaa 2313421 aaactcctca gttttactgc ttgatctgtt gtaaacagaa acagaaaatc cccggctttc 2313481 gatatttaaa gccagatttt tacccatgac cgcaagtccg ataacgccga tttgttgttt 2313541 tgacatattc taacgtccct tctgcaaacg tttaatcatt ttaaaattta aattaaaata 2313601 aaatgatatt tataataaag aaattaccat acattcaccc tttttttcaa gcgattcagc 2313661 ttttcttttc atcttgaaaa aaatctttat taaagcttgt tccctttgtt ttgctctcct 2313721 ctttttttaa cgttgcccct tttctgatca gtttggtacc gtacttttta ttcagctttt 2313781 ccatcatctg ctgaatgggc tcatccttcg catcttcatt aaagctgaac aaatcgagct 2313841 gtttataggc ctgctctttt tctactaaat ccgttccggt aatgccaagc agcctgacag 2313901 gatttttatt ccaatgttta aaaaagaggt gctccgcttc tttcaaaatg tcattttttt 2313961 gatcaatcgg gtttctcagc gtagtgcttc ttgtgatggt tctccaatcc gcatatctaa 2314021 tcataataaa aagcttcgaa gccatgactt ccttgcgctg taaacggtca ctcacagaag 2314081 cggcaagctt tctaaaaacg cctaacagct cttcttcatc actggaatca tgggaaagtg 2314141 tcgatgagtt gccgacgctt ttaaattcgt aaatgcgctc cgggtcaacc ggcgcatggt 2314201 gaatgccatt tgctttattt ttaaggcgcg gaccgttgat gccaagcagg cgcttcagcg 2314261 agtgttcatc agctgcagct agctctccga ttgtatggat gccgagtccc ttcagttttt 2314321 ccgctgtctt tttgccgact ccgtgcatct ctccaacagg aagcggccac aggatatcgg 2314381 gcacttgcct ctttcttaag atcgtaattc caagcggttt tttcatatca gacgccatct 2314441 tagcgagaaa tttattcggt gcaatcccta tgcttgacgg gagcagcagc tctttttgca 2314501 gcctgctttg gatttctttt gccgtctcta gagcgcggct gctgtatggt gtatcggtca 2314561 tgtccatata gccttcgtcg atggagacag gctccactag gtcagtatat tcacgaagaa 2314621 tggtaaacat cgctcgtgaa gagtttctat agcggtcaaa gttcggcgga agaacgatga 2314681 gctcaggaca atggcgcttc gcttgccaaa ccggcatcgt tgttttgacg ccgcgcgctc 2314741 ttgcttcgta gctgcatgtt accacaatgc cctttcgctc ctttacgttt ccggcaactg 2314801 cgaccggctt tccccggaga gccggatcat atgccatttc aaccgacgca taaaagctat 2314861 tcatatcaat atggaaaata attcggctct ttcccggcat aaacaaatct ccttttcggt 2314921 cattagacaa cagcttgtac atatagtaaa atgaagctat tgaatggatg tgatgacaat 2314981 gtttgtggaa tcgataaatg acgttttatt cttagtcgat tttttcacaa ttattcttcc 2315041 tgctctaacg gcaatcggga ttgcattcct cttacgggag tgccgtgcgg gcgagcaatg 2315101 gaaatcaaaa cgaacagatg aacatcagac ggtctttcac attaaccgaa cagactttct 2315161 tattattata tatcatcgca ttacaacttg gatacgtaaa gtcttccgca tgaattcgcc 2315221 tgtgaacgat gaggaagacg ccggttctct tcttttataa accgcattta taaaaaggag 2315281 gagaacaaaa ttgttaaaaa catatcaaaa acttttggct atgggtatct ttttgatcgt 2315341 attatgctcg ggcaatgctg catttgcagc gactaatcag gtgggaggcc tcagcaacgt 2315401 aggttttttc cacgattatt taatcgaacc gttttccgct ctgcttaagg gtgttgccgg 2315461 gctgtttcac ggagaatacg gactctctat tatcctcgta accattattg tgcgtatagt 2315521 tgtattgcct ttgtttgtca atcagttcaa aaaacagcgc atcttccaag agaaaatggc 2315581 cgttattaaa cctcaggttg acagtatcca ggttaagttg aaaaagacga aggacccgga 2315641 aaagcaaaaa gagctgcaaa tggaaatgat gaagctgtat caggagcata atatcaaccc 2315701 gcttgcgatg ggctgtcttc caatgctgat tcagtctccg attatgattg ggctttatta 2315761 cgcgattcgc tcaacacctg aaattgcgtc acactcgttt ctatggttca gtttagggca 2315821 atctgatatt ctcatgtccc ttagtgcagg gattatgtat tttgtccaag cctatatcgc 2315881 tcaaaaactg agcgcgaaat attccgctgt cccgcaaaac cctgcagcgc agcaatccgc 2315941 aaaattgatg gtgttcatct tccctgtgat gatgacgatt ttctcgctta atgtgccggc 2316001 agcccttccg ctgtactggt ttacaagcgg actgtttttg acagtgcaaa acatcgtcct 2316061 tcagatgacg catcataaaa gtaaaaaaac agccgctctt actgagtcgg tgaaataaaa 2316121 aagcaacccc gtgcaaaaag ccggggttgt tttttgttac ttgcaaagta ccgcgccaaa 2316181 cagtcttgtt tatcatggct gaagcagaaa tggccatcct aaaaaatagc cgtatcgttt 2316241 aaaaagaagg aaatcgggaa tacctttact cacctccaac cgaaaggagc ctatacgttg 2316301 acggaacgct ttcagcaaaa aaatatttct gtacctgatg gaatctggat catgagacaa 2316361 acctggaatg atgtcttatt tgctcactgg cctgttgatg tttctatcct tcgcgctttg 2316421 gtaccgtccg ttttagaatt agatacatat aacgggcaag cttggatcag catgcttccc 2316481 tttatgctca cgaacctgag ggcgcgttat ctccctgtca ttcccggtgc gcgtgcattt 2316541 cctgagctta acctccgcac ctatgtcacg tataaaggca agcccggcat ttattttttt 2316601 agcttagatg ccgatcatcg tctggcggtc cttggcgctc gcacattctt tcatctgcct 2316661 tatttttacg cggatatgaa gtccgaaaaa aacggtgatg ccattgacta tgtcagcaag 2316721 cggaaaaatg acaaagaagc agcattccac gccgcatacc ggccaatttc agcgcctttt 2316781 acagcagaaa aggattcgct cgattactgg ctgacagaac gatacaggct ctacaccact 2316841 tatcgcaata agctctatta cgaagacatc catcatcatc cgtggctgct gcaaaacgcc 2316901 gaagcagaaa tttcagtcaa tacggtgact gatgctcacg gtattacatt gccggagtca 2316961 gaccccttgc ttcattatgc taaaaaacag gatgtgttat tttggccgct taggaaatgg 2317021 agctaaaaaa acccgatgcg ggaaatcgca ctcgggtttt ctttttttat tttgccgcct 2317081 cttcaataat ggcaacaacc atttctgccg ttttaacgag ctcttcgatc ggcatttttt 2317141 cattttttgt atggatttgc tcataaccga cagcaagatt gaccgtcggg atgccatgac 2317201 cagcgattac gttcgcgtcg cttccgccgc cgctcgtttg cagctcgctt ggacgtccga 2317261 ttttagcagc cgcttttttc gcgatttcaa caacttggtc gccgtcttga tatttaaagc 2317321 ccggatacat aacctcaatt tcgacttctg cgcgtccgcc catatcagca gctgcctctt 2317381 caaaagcagc tttcattttt tgaacctgag cttccatttt ctcaggaact aaagagcgcg 2317441 cttcagcaag aatatgaact tcgtcgcaca caatgtttgt ttgtgtgccg ccttcaaacc 2317501 ggccgatatt agctgttgtt tcttcatcga tacggcccaa tggcattttt gagatggctt 2317561 tgctagcgat tgtaatcgct gaaatgcctt tttcaggttc aaccccggcg tgagcggttt 2317621 tcccgaaaat tgccgctctt accttcgcct gtgtcggcgc ggccacaatg atatttccga 2317681 cttttccgtc tgaatcaaga gcatagccgt aggatgcagt gatcatagaa cggtcaagcg 2317741 ccttcgctcc gatcagaccc gattcttccc ctactgtgat gatgaattca atcgtgccgt 2317801 gttcaatatt ttcttctttc agcaccttaa tcgcctcaaa cattgcagcc aatcccgctt 2317861 tatcatcagc acctaaaatc gtcgtgccgt cagttttgac gtaaccgttc tctacaactg 2317921 gttttacgcc gtttccgggt acaactgtgt ccatatgaga tgtaaaatag atcgtatctg 2317981 tttgttttgt cccttttagc gtgcaaatca ggttaccggc tccgtggccc gtgatatcca 2318041 ttgtatcgtc ttctttaacg tccacaccta aatcagaaaa ttttcgtttc agcactttgc 2318101 agatttcagc ttcgtgcttt gtttctgagt caatttggac aagctctaaa aattcttcca 2318161 gcaggcgttt ttcattcacc atttgtaagt ccctccatat taaagcggta tgttaccgtg 2318221 cttttttttc ggtctctctt ctgtcttatg tgtaagcata tgaaaagctt gaatcagtct 2318281 tccccttgat tcttccggca aaatgatgtc atcgaccatt ccacaagcgg ccgctttgta 2318341 tgggccggcg ttttgctttt tgtattcagc agttttttcg cgtttcgtct tttgcgggtc 2318401 agctgaagct ttgatttcct tttcatacaa aatcgatgcc gcaccttctg gacccatcac 2318461 tgcgatttca gcattcggcc atgcaaacac aaggtccgct ccgatcgctt tgctgttcat 2318521 ggccacatag gcgccgccgt acgcttttct aatgatgagt gtgacttttg ggacagtcgc 2318581 ttcagcataa gcaaacaata attttgctcc atgcctgatg attccgttgt gctcttgctg 2318641 aatacccggc agaaaccccg ggacatcttc gacagtcaac agcgggatat caaatgcgtc 2318701 acaaaaacgg atgaaccttg ctgctttatc agcagcgtca atcgtcaggc ttcccgccag 2318761 atgcttcggc tggctcgcca cgatgccgat tgctttttca cccagccttg caaacccaat 2318821 gacaatgttc ttcgcaaaaa atggctgaat ctcaaaaaaa gactgcgggt cagccagctc 2318881 cctaatcacc ttccgaacat cataaggctt tgtcgtatca gcagggacaa gacggtttaa 2318941 taacggtctg gacgcctctt tctctggctt cggctctgtt gtccggccat tcagcggcaa 2319001 ataagacagt agttttctca cccctgtcag aacctccttc tccgtatgcc cggaaaagtg 2319061 ggcgtttccg ctgacggcat tatgtatccc cgctccgcct aagctctccg catcaacctg 2319121 ttcccctgtc actttttcaa tcaccttcgg gccggtaata aacatccggc cagtctgttc 2319181 agccataaat ataaaatctg tgagtgccgg agaatataca gcgcctccag cgcacggccc 2319241 taaaataacc gatatttgcg gaatgactcc ggaatataag acgtttcggt aaaatatgtg 2319301 accgtatcca tctaatgata acacaccctc ttgaattctc gcaccacctg agtcattcag 2319361 cccgataatc ggcgccttat tttttgctgc cagatccatc aaagcgcaga ttttcctggc 2319421 atgggtttcg ccaagcgccc ctccgtacac tgtgaagtct tgcgcaaata cataaactga 2319481 gcgaccgtca attgtgccgt accctgtcac gaccccatcc cctaacatgc gctgttctct 2319541 tgttaacact tgactttcca tgaaggggtg taattcgata aagctgtcct gatctagaag 2319601 aaatatgatc ctttcccgag cagtgagctt gcccttttgc cgctgctgag ccagcttttc 2319661 ccgtcctccg ccttcttctg cctgcttgcg tttcgtgtaa aaatgatcca tgtgctcatt 2319721 catgctcatt gtgttggtct cctttcggtt cacaaagctc tacaagaaca ccgtttgttt 2319781 cccgagggga aataaacgcg atctttttcc cgttcgctcc ctgtcttgga aacctgtcaa 2319841 tcaattgaac atgctgatca gacaatgctt gaagctgttc agataggcag ttgcacaaaa 2319901 acgcaatatg atgcagtccc tgccctttct tctccaaaaa taaatggacg gggctgtcag 2319961 ctgtcaacgg ctctatcagc tcaagtttga cgctaccagc ttgaaaaaaa gcaacattca 2320021 ccttttgctc ttcaaccgtt tcttgatgaa gaaatgcaag ccccaataca ttttcataaa 2320081 agcttcttgc atcttttatc gaaaaaacgg ctatcccgat atggtcaagc ctgttcattt 2320141 tcatccctgc tttcgctaat agatatcgct tgtccgccca ttcaaaacac gctaaaatat 2320201 agacagattg tttaaggagt gaaaatcatg tctcaaaaac tgatgaaaag cgttttgatc 2320261 gtgattttgg gagtttttat tctttcaact gtactctcag gaatcgtcat gtttctataa 2320321 cgataaaaaa gcaggcgcct tattcaatgg gaatatcctg cttttttatc agagctttat 2320381 gctcgatggc aatctcctca aaagagcggt tgtcgtccgt gatcagcact ctcgttccta 2320441 ctggtatcgt ttgaaacaaa tgaacaacct catcgttatg catacgtata cagccgttag 2320501 acacaaattt tcctactgat tcctctcggt ttgtcccatg aattccataa atccgcccgt 2320561 ccgttccttt cgcgtcaaat ccgatccatc ttgccccaag cgggttatca ggagatcccc 2320621 cttcaatatt tttctttctg tagtaaggat tttccgcttt taccgttacc gaaaactctc 2320681 cttcaggcgt caaatcatct gtttttccag tcgccacact atacacgcct tctactttgt 2320741 tgtcgaggat aacagcaagt tcatttgttc gcttgttgac aataacatac ggatcacccg 2320801 gcagcggatt ttcgccgagc ggccaaatcg gtgaaatcat catgaaaatc gaacataaga 2320861 aaaaacgcat aagctcctcc tttttcatta ggttgaccaa tgaaggaaga gctcatgcga 2320921 atcatccgag tgatttttgc gcttttattc ctttaaaata acttttaatc actaaatatt 2320981 gttccatttc gccgagaaga tggaagagag cggccctcgc ttcaaattcc tctctagtcg 2321041 caggaagcgg catctcctca aattcttttc tcatgtcagc aagtcttttc agaaatttgt 2321101 atgctgtatt cccagggtgt atcgcctccc gcaaatcatg aataaattca gcgatcattt 2321161 ttccctgatc taccgtgatg gagatcgatg tcactttagg gagaaggcgt tcgataattt 2321221 caaattgctt ttctctcatt ttaaaataat gataatgcag attttcataa cgcaaaatgt 2321281 ggttttgcac atctcgatat gccaggtttt tagcctccgt aatgagctgg tgcgtttccg 2321341 gaatttcttt tcctgaccaa tcttgctcac cagttaacaa ataccgttcg atttctgcaa 2321401 aaatgacagc aaagttatcc tctatctttt tgcggtaggc aatcagtttc cggtcaagac 2321461 taggcatata caagttcatc aatagagcga cgccgatgcc aaccgtaatc agctgaactt 2321521 cattccagat gaaagtaggc gtaatgccgc cggacatgta taaatgaagg ataataacag 2321581 aactggtgac gataccctcg ttaattttta acagaaccgt tatcggaatg aatatcaaaa 2321641 gaagcgctcc gatcacaaac gggtggtagc caataagctc gaaaaagaga taagaaaaag 2321701 caattgccag acagcatgcc gaaaagcggg cccatgaggc ctgaagcgac cgtttttgtg 2321761 tgatttgtat gcacaaaatg gtgatgattc ctgctgatgc gaagttttgc aaatgcaata 2321821 actggcttat ataaatagcc aaagctgttc caagcgcggt ctttattgtg cggtaaccaa 2321881 ttttaaacat gtcggactcc atttctattt gtttcttcaa taaaaaagaa gaggcggcca 2321941 gccttcttct tttttatatt ctataatatt ttctctaaaa agtcctgcgc tcttttggat 2322001 tttggcgaca taaaaaattc cttcggattg ccgtcttcga caatcattcc ttggtccata 2322061 aacagcacac ggtctgccac ttcttttgcg aagcccattt catgtgtgac aatcaccatg 2322121 gtcatgccgg tttcgaccag ctctttcatc acctgtagca cttctttgac catctctgga 2322181 tcaagggcgg aggtcggctc gtcaaacagc atgatgtccg gattcatcgc aagagccctg 2322241 gcaatcgcga cacgctgttt ttgtccgcca gacaaacggt ttggatagtc atttcgcttt 2322301 tcaaacaaac cgactttgcg gagcaggtcc tcagctttct cctgtgcagc ctgttttgat 2322361 tcttttttta cattgacagg cgcgtacatg atgttttcga gaaccgtttt gtgcggaaag 2322421 agatgaaaat gctgaaaaac catcccgatg ttttcccgga cctttaatgt gttggttttc 2322481 ggcttcgtaa tctctgtgtc ttttattgta atggttccgc cgttaggctt ttccaacagg 2322541 tttaaacagc gtaagaacgt tgatttgcct gagcctgaag gaccgatcac ggcaacaacc 2322601 tcaccctcag cgattgttgt tgaaatgttt tttaatactt cgtgtttccc aaatgatttt 2322661 gacagctttt caaccttaat cattggattt cagcttcctt tctacagcct tgccgataaa 2322721 cgttaaaatc aggacaagca cataataaat caatcccgcg ataatgagcg gctcaaggta 2322781 attgtaagtg gcggcgccag cttgatatgc gcgtctcatg acatcaccaa gcccgatgac 2322841 ggtgacgatc gccgattctt ttgttaacgt aattaattca ttcacaattg caggtgatat 2322901 atttttgaag gcctgcggca gcagcagatc cttcatcatt tttccatacg ggacaccgag 2322961 tgcaacagca gcttcttttt gccctttatc aatggcattg attccggctc tgataatttc 2323021 cgatacataa gcggcggaat tcaaagacaa tgcgacaacc gcagcccaaa actggtcaat 2323081 ttgaaatccg agcagctgag gaaggccaaa atagacaatc ataagctgca gcactaaagg 2323141 cgtgcctcgg aacactgatg tataaaaatc agcgatccag ataaacgggc ggaatgtgct 2323201 gatcttgcat aagcttagca caataccgag tataagtccg ataatagcag atacaacaac 2323261 aatttttaat gtaattgcca agccttctaa tataaaagga atttggggga tcgttgctga 2323321 aaaatccaaa ttcatagcct ttgtctcctt ttcttacagg aaaaaagttt cctattcaat 2323381 aaaaaggctc aacgaaaaag ttgagccgct tttttttact tctcgccagt gaaccatttt 2323441 ttcttcaatt tctcaagctc tccgttatct tccatttcct tgagcgcttt attgaatttg 2323501 tctgtcagtt cactgtcctt tctgaaagca attgctgaac cggcttcttc cgctttcgca 2323561 tcaggaatca caaagccttg caggtcatca tttgatttga aatacccttc tgcaacaatg 2323621 tcttcaataa tcgcggcatc gaagcggtca gatttgattt cctgcaccaa atcagaaatt 2323681 ctgttgcggt cttctgtttt aaaaccatat tccggagaaa gctctttccc cttctcttcc 2323741 tgaatagagc caagctgaac gccaactgtt tttcctttca ggtctttcaa agattgaatg 2323801 ccgctgtctt ttttgctgac aatcatatgg ttcgctgtgt aatacacatc ggaaaaatca 2323861 acttgttttt tacgctcagg cgttggtgtc attcctgaca gaacgagatc cacctgtttt 2323921 gatttaagcg ctgtaattaa gctgttgaag tccatatcct gcacttcaat ttcatagcct 2323981 gccttctttg ccagagcttt tgccagctct acatcaaagc cgacaatatt atctccttct 2324041 ttatattcaa acggtttgta atccgccgaa gtacccataa ttaatttttt ctttccgctt 2324101 tctgaacctg aattgcttga gccgcacgca gttaatgcaa aggtgatgca agcagccaca 2324161 agtaataaga gccatttttt catgatccat ttcccccgta ttcattactt ttggtgtatt 2324221 tgaatattta ttcgttaatt tgtattttaa acagtttctc atttttatgc aatactattt 2324281 ttaaaaatta tctttaggct tatctttcca gtgatctctt ctgatattac tagataaaaa 2324341 ttaaatcgct gtacaatccg attgaataat cccttaatat ttattcatat atccttggaa 2324401 atttatgcac aaaaaaaccc gggctgcttt gagcatccgg gttgttcgtc ttatacttct 2324461 tcacaatatt cttcaaaggc ttcctgcagc tttgccacta cagccatcgg ctcatggcct 2324521 tcaatttcat gacgctctac cattttcatg atctttccgt ctttcaaaat cgcaaaggac 2324581 ggagaagatg gtggataacc ttcaaaatag tcacgcgcac gcgctgtcgc ttctttatcc 2324641 tgtccggcaa aaacggtgac gagctgatca ggtcttttat catagtgaac ggaatggtag 2324701 gctgccggtc ttgcaattcc tccggcgcat ccgcaaacag agtttaccat gacgagcgtc 2324761 gttccttttt tcgtaagtgc ctcatccacc tcttcggctg ttttaagctc ggtgtatccg 2324821 gcagctgtta tttcttgtct cgcttggcgg acaatatcat tcataaataa attaaagtcc 2324881 atgttcaatg aagacctctc ctttttcatc atctgttctt atgatagcaa ggaaacgtcc 2324941 atatcggcaa atgactttgc ttcgccgtgc actttttttg ctcttcgttt actgcttaca 2325001 gaaaaagggg attatataac cagaagtaaa ataaaggagc agttgtatat gagccaccgg 2325061 aaagcgttac tgattcataa cggaaatgcc ggcaacaaaa atatagaaaa agcacttggt 2325121 gctgtggtgc cggttttatc tcaccattta gatgaggtga ttattaaaca gacaaagaaa 2325181 aaggatgatg cgtatcattt ttgccgatcc attgatgatt ctgtcgacac cgtcttcatt 2325241 ctcggcggcg acggcacgat ccatcaatgc ataaatgcta tcagcgctct agaaagaaaa 2325301 cccgctgtcg gaattttgcc cggcggcacg tgcaacgact tttcaagagt gcttggcatc 2325361 cctcaaaatc ttgcaaaggc cgcggaagca cttatggcgg gaaaaaaaac cagcgtagac 2325421 gtatgtcaga tgaatgaccg ttattttttg aatttctggg ggatcggctt aattgcagaa 2325481 acgtcgaatc aaatcaacga aacggaaaaa gcattattgg gaaaaatcag ctattttaca 2325541 agtgccttgc gaaccgtctc atctgctgca tcgtttccga tgacattaaa aattgatgga 2325601 gaagaaatta aagaagaagc cgttatgctg cttgtgatga atggccaata cattggaacg 2325661 aatcgaattc ctctgcccga tgccagtatt gaagacggct tacttgatgt tctcatatgc 2325721 cgcaatacca acctcaccgc gctgcgggag ctgatgagca tggaacaagg ctcaattgat 2325781 cgttttactg gagagttgtc ctatgtccag gcttcccgta tcgagattga aacagacact 2325841 gccaaaaagg cggatatgga tggagaagtt tatacacata cacccgcagt cattcaggtc 2325901 ctgccacagc atatcgacat gcttgttccc gcaaatgaat aactgtcata aggctttaga 2325961 aagattttgc aaatccgttg actctcccct aggaggaggt cttacagtat aagggataca 2326021 cacttgaaaa aggggaagtc atatggagaa gaaaaatatt accttaacta tattattaac 2326081 caatttattt attgcttttt tggggatcgg gcttgtgatt ccagtaacgc cgaccattat 2326141 gaatgaattg catttatcgg ggaccgcggt cggctatatg gttgcctgct tcgctattac 2326201 acagctcatt gtctcaccaa tagccggacg atgggttgat cgcttcgggc gcaagatcat 2326261 gatcgtaatc ggcctgttgt tctttagtgt gtcggagttt ttgttcggca ttggaaaaac 2326321 agttgagatg ttatttatct cccgtatgct gggcggtatc agcgcagcct tcattatgcc 2326381 cggggtcacg gcttttattg cagatatcac gaccattaaa acacggccaa aagcgctcgg 2326441 ttatatgtca gccgctattt caacaggatt tattatcggc cccggcatcg ggggattttt 2326501 agcagaagtc cattcccggc tgcctttttt ctttgcggca gcttttgcac tgttagcagc 2326561 cattttatca atcctcacgc tgcgcgagcc ggaacgaaac cctgaaaatc aggaaataaa 2326621 aggacagaag acaggcttta aacgaatttt tgcccccatg tatttcatag cttttctcat 2326681 tatcttaatt tcgtcttttg gtttagcatc atttgaatct ttatttgcat tattcgtgga 2326741 tcataaattc ggatttacgg ccagcgacat tgccattatg attacaggag gagcgattgt 2326801 tggcgccatt acgcaagtcg tcttattcga ccgcttcaca agatggtttg gcgaaattca 2326861 tttaattcgg tacagcttaa ttctctcgac gagtctggta ttcttgctga caacggtaca 2326921 ttcatatgtt gcgattctgc tggtgacagt caccgtattt gtcggatttg atctcatgcg 2326981 gcctgcggta acgacttacc tgtcaaagat tgcgggaaat gaacaggggt ttgccggcgg 2327041 tatgaattca atgtttacaa gtatcggcaa tgtattcggg cctattatcg gcggaatgct 2327101 gttcgatata gatgtaaact atcctttcta ctttgcaacg gtcaccttag ccatagggat 2327161 tgcactgacc attgcttgga aagcgcctgc acatcttaaa gccagcacgt gataagaagc 2327221 gcattctttg tgtactgcaa agaatgcgct tcttctttat actgatgata gaaggagtga 2327281 tggcatgaag gaatcgtatt actcaattgg ggaagtatca aaactggcaa acgtgtcgat 2327341 aaaagcgctc cgttattacg ataaaattga tttatttaaa ccagcctacg tcgacccgga 2327401 taccagctac cgctattata cagattctca gctcattcat ctggatttga tcaaatcatt 2327461 gaaatatatc ggcacacctt tagaagagat gaaaaaagca caggacttag agatggaaga 2327521 actgtttgct ttttatacag agcaggagag gcaaatcagg gagaaattag actttttatc 2327581 agccctggag caaaccattt cattggtgaa aaagcggatg aaacggcaga tggaatatcc 2327641 cgcgctcggt gaggtgtttg ttttagatga agaagaaata cggatcattc agacagaggc 2327701 agaaggaatc gggcctgaaa acgtgctcaa cgcctcctac agcaaattaa aaaaatttat 2327761 cgagtcagca gatggattta cgaacaatag ctacggcgct actttctctt ttcagcccta 2327821 caccagcatt gatgaaatga cttaccgtca tattttcaca cctgtattga cgaataaaca 2327881 gatttcatca attacgccgg atatggaaat cacaacgatc cctaaaggga ggtatgcgtg 2327941 tatcgcgtat aatttttcgc ctgaacatta ttttctcaac ttacagaagc ttatcaaata 2328001 tatcgcggac cgccaattaa cagttgtcag tgatgtatac gagttaatca taccgattca 2328061 ttactccccg aaaaaacaag aagaatatcg agtcgaaatg aaaatacgga tcgctgaata 2328121 ataaagcata gaaaaagagc attttttgaa acaaaacttc aaaaaatgct ctttttgctt 2328181 atttagtaaa cagatgtctt ctcgtcaatc gattctaaaa tttgtttcac tcgtccgagg 2328241 aatcgtccgc acacgagacc gtcaagcact ctgtgatcta atgacaggca cagattaacc 2328301 atgtctctga cagcaatcat gccattgtcc atgacaaccg ggcgtttgac gatggattct 2328361 acttgaagaa tcgcagcctg agggtagttg ataatgccca tcgactgaac agacccgaac 2328421 gaacctgtgt tgttgacggt aaacgtgcct ccctgcatgt catctgcagt gagttttccg 2328481 tctcttactt ttttagctag gccggtaatg tctttcgcaa tgcctttaat tgttttttca 2328541 tcagcgtttt taatcaccgg aacaaataaa gaatcctctg tggcaactgc aattgaaata 2328601 ttgatatcct ttttctgaat aattttgtcc cccgcccaca tgctattcat ttgcgggaat 2328661 tcttttaacg cctgagcgac cgcttttaca aaaaaggcga agaacgttaa attaaagcct 2328721 tctgtcttct taaaagaatc ttttatactg ttgcgatatg caaccatatt tgtgacgtcg 2328781 acttccatca tcgtccaagc atgcggaatt tctgttttgc ttcgcttcat attggaagca 2328841 attgcttttc ttacacctgt gacagggatt tctttatcac cggctgcaga cgcaggatat 2328901 gacgtctctt cttttggctc aggttttgat gcagacttcg gtgcaggagc tgctgttttc 2328961 agctcctcag gattctgttc ttgcacgccg cctgtttcaa ttaagcgctg aatatctttt 2329021 cgtgtgatgc gcccgccggc accagttcct gtcacttgat cgaggtcaat gccgtgctct 2329081 ccggccaaac ggagaacagc tggcgagtag cgctttttat tgggctgatc ggctgctcca 2329141 gcactttttg caacagggtt ctcagcggct tctgatgctg ctggctgttc ttgtttttgt 2329201 tcagccggat tcgcgccttc tgtttcaatt ttgcaaatca tttctccgac ttgcagggtt 2329261 tggccttctt ctcccacaag ctctgttatc gtaccagtaa aagaagacgg aacctctgca 2329321 tttaccttat ctgtcatgac ttccgcgatc ggatcgtatt tgttcacttt atcaccgggg 2329381 gcgacaagcc atttgctgat cgtcccctct gttacgcttt ctccaagctg cggcatcgtc 2329441 atttgttcaa ttgccatgat tgtatcctcc cttacgtctt taaaactccg ctaattctct 2329501 catcgccgct tccactttat cagggttgac cataaagtat ttttccattg tcggcgcata 2329561 aggcatagcc ggaatatcag gacctgcaag ccgtttgatc ggcgcgtcta agtcgaacag 2329621 acaatgctcg gatataattg cggctacttc gctcatgatg ctgccttctt ttgtatcttc 2329681 tgtgaccaaa agaacctttc cagttttgga cgcagcttcg atgatggctt ctttatcaag 2329741 cgggtaaact gttcttaaat ccaccacatg cgctgaaatg ccatcttttt cgagacgttc 2329801 tgcagcttgt aaggcgaagt ggacacacag gccgtatgtg atcactgtga tgtcgtcgcc 2329861 ttcccttttt acgtccgcct tgccgattgg caggacataa tcatcagccg gaacctcgcc 2329921 ctttatcaga cggtatgccc gcttgtgctc aaaaaacagc acggggtctt cgtcacgaac 2329981 tgcggctttt aagagccctt tcgcgtcata tggtgttgat ggcatgacaa ttttcagtcc 2330041 gggctggttg gcgaaaattg cttcgactga ttgagaatga tacagggctc cgtgcacgcc 2330101 tccgccgtat ggcgctctga cgacaatcgg acagctccag tcattgttgc tgcggtagcg 2330161 gattttagcc gcttcagaaa taatttggtt gactgccggc ataatgaaat cagcaaactg 2330221 catttcagca atcggtctca ttccgtacat tgccgctccg ataccgactc ctgcgattgc 2330281 agattcagca agcggcgtat ccataacgcg ctcttcccca aattgttcat agagtcccgc 2330341 tgtcgcttta aacacaccgc cttttcttcc tacatcttcc ccaaggacga aaacgcgaga 2330401 atctcgttcc atttcttctt tcatcgccaa attgattgca tcaatatatg acattactga 2330461 catttgttct tcctccctac ttcgcataaa cataatcaag cgctgactca ggagctgcat 2330521 atggggcgtt ctccgcttca tccgtcgctt catttacgat tgccataatt tcatccagca 2330581 tggtttgttc tatctcatcg gacagcaggc ctgtttcctt taagtaagct tgataagtaa 2330641 gcaggggatc actttttttc gcttcctcta cttcttcacg gcctctgtag ctgctgtcat 2330701 cgtcatcact ggaatgtggt gtaaggcggt aagaaatcgt ttcaattaat gtcgggcctt 2330761 ctcctctgcg tgccctttcg cgtgcttctt taaccgcttg ataaacttcc agcggatcat 2330821 ttccattcac agttacgcca ggcatcccat agcctatggc acggtcggaa atgttctcac 2330881 atgcgacttg cttatcgtaa ggcactgaga ttgcgtattt gttgttttca cacatgaaaa 2330941 taaccggcag cttatggaca gcggcaaagt ttgccccttc atggaaatcg ccttggtttg 2331001 aagacccttc cccgaatgta acaaaggctg cgatatcctt tttctccata cgtcccgcaa 2331061 gcgcaatacc gactgcgtgc ggcacttgcg ttgtaaccgg agatgatccc gtcacaatgc 2331121 ggtttttctt ttgtccgaaa tgtcccggca tctggcggcc tcctgagttc ggatctgctg 2331181 cttttgcaaa cccggacatc attaagtcct ttgctgtcat gccaaacgcg agcacgacac 2331241 ccatgtctct gtagtacggc aatacataat ccatttcacg gtcaagtgcg aaagccgctc 2331301 ctacctgtgc tgcttcctgt ccttgacaag agattacaaa tggaattttg ccagaacggt 2331361 ttaacagcca cattctttca tcgatttttc ttgctaacag catggttcta tacatatcaa 2331421 cggcttcctg atcagtcagc cctagtgctt gatgtcggtt tgtactcatt caagcccctc 2331481 ctttatgctt ttaaaaatga atggctttgc catctgcggc aagcgcagct tctccaattg 2331541 cttcagaaag cgttggatgc gggtgaatcg tttgcccgac ctcccacggt gttgcgtcca 2331601 gcactttggc aagacccgct tcagaaatca tgtcggtgac atgcgggcca atcatatgaa 2331661 cgccgagaat atcatctgta tctcggtcag ccacgatttt gacaaaaccg tcgctttcac 2331721 cgtatacaag cgcttttcca atcgccataa atgggaactt gccgattttg acattatgcc 2331781 cgttcgcctt tgcttcgtct tcggttaagc cgacactggc agcttcaggg cttgagtaaa 2331841 tgcacttcgg cacaagcgtc ggatcaagcg gatgcggatt gagacctgca aaatgctcaa 2331901 cagcaataat tccctcatgt gaagcaacgt gagctaactg caggccaccg attacgtctc 2331961 cgattgcata aatatgagat tccttcgttt ggcagctttc attgactgaa atcatgccat 2332021 tttcagtaac aatatcggtg ttctctaggc cgatgccttc gatatttgcc tgtctgccga 2332081 tggaaacaag cattttctca gcagaatagg taacggtttc tccgtctttt tccgcttgta 2332141 tgctgatatc gtctgatgtt tttgtcattg tgtcaggcag cacttttgcc cctgttatga 2332201 actggatgcc ttttttctta agaagacttt ccatttcttt tgaaatctct agatcttcag 2332261 tcggcaatat gcgatccgcg tattcaataa ccgttacctt aacgccaaaa tcatgaagca 2332321 tagacgccca ttcgataccg ataacccctc cgccgacaat gatgattgac tgtggcagct 2332381 cctccatttg gagcgcctca tctgaagtca gtacagactt accgtccact tcaagacccg 2332441 gaagcattct cggtcttgat cctgttgcaa tgatcacttg tttcgggatc agcatgtcat 2332501 tttcttcgcc atttccccgc tcaacagaaa ttgttcccgg cagcggagag aagattgacg 2332561 gtccaaggat acgtccatat ccggtgtaca cgtcaatttt tccttttttc attaaatgat 2332621 ttacacccgc tgcaagctta tcaacaacgg cttgcttacg ctgctgcact ttttcaaagt 2332681 tgagggacac gccagccgtt tccactccga attgatcggc ttcacgagct gtccggtata 2332741 cctctgcgct tctaagcagc gctttactcg ggatacagcc tttatgcaga catgttcccc 2332801 cgagtttttc cttttccaca acggctgttt ttaagccgag ctgagcggct ctgatggccg 2332861 caacataacc gccggtaccg ccgcccagaa tgactacgtc atactcagtt gccatggtga 2332921 ctcactcctg tctgtctatt caatacgata ttgtttggat tgctcttcgc cctgcaatac 2332981 tcttagcgcc ccttgggcaa gagactgcag ttcattttca cccggataaa ctaaaacgtc 2333041 tgaaatccaa tctatgtatg atctgatagc agaaacaaag ctttttccgt acgcaaggcc 2333101 tcccgtcagc acaatcgctt caacttcgcc ttttaacgcc gcgctggctg ccccgatttc 2333161 ctttgctacc tgatatgcca tggcatcata aatgaagcgg gctttttcat cgcccccttg 2333221 aatcatctgt tccactttta ctgcatcatt tgtaccgaga tagcctaaaa gtccgccggt 2333281 gccaacaagc tttttcatga tttcttcttt tgtatattcc cctgaaaaac atagatcaac 2333341 aagatctccc gcaggcactg ttcctgctcg ttcaggactg aatggtccct cgccgtgcag 2333401 gccgttattg acatccacca ctcgcccgcg gtcatggacg ccaattgtaa tacctccgcc 2333461 catatgggta ataatcattt tcatgttctc atatcgtttg ccaagggagg ctgccgcttt 2333521 acgagcgaca gctttttggt ttaacgcatg gaaaatgctt ttcctttcaa tttcaggcat 2333581 gcctgaaact ttcgcaagca ctgacatttc gtctacgaca acagggtcga cgatatacga 2333641 agggatattc aggccgtcag cgatttcccg cgcgataatg ccgccgagat tagaagcatg 2333701 ctgaccggcg tagccgcttt tcaaatcctc aatcatctca tcattcacta cgtaggtccc 2333761 gccttcaatt ggccggagaa ggccgcctct tgcgcagact gcatcaaact ttgaaatatt 2333821 gattccctgt tcatgaagcg tttcgagaat atggttttta cgaaattcat actgatcaat 2333881 aattcggtca aatcgctgca gctcttctat gttgtgtctc aatgtttttt caaaaatgct 2333941 tctttcgtta tgaaaaacac cgattttcgt tgaagttgag cctggattaa ttgtgagaat 2334001 gcgtttttcg tcatgtagca ctttcataac ctccagatca atttcttaac gtctgcttaa 2334061 tacactgtgg ccgttttgca aaaactggct tcttgagcgg cgcatgcgtt caatccgttc 2334121 ctctgctaag cggtcagccg ctaaatatgc aggaatgccg tcacgctgag aaatctcaag 2334181 tacacgctcg atattgccgt aaatgccttc aacttttttc aatgcacgtt ctgcattata 2334241 gccgtaaagc tcatctgcca cgttgatgac accgcccgcg ttaatcacgt aatccggtgc 2334301 ataaacgatg cccatttcgt gaatttgatc accatggcgt gtctctttta attggttgtt 2334361 agccgcacct gcgatcactt tcgccttcag ctgtttaatg gtgtcgtcgt taatagtcgc 2334421 accaagggca cacggcgcat aaatatcgca gtcttgtgaa taaatgtcat caggatctac 2334481 cgcacgggcg ccaaaatctt caactgcacg ctgtacagat tgtttgttga tatccgtaac 2334541 gattaagttt gctccttctt catgcaggtg gcggcaaagg ttataggcta cgttcccaac 2334601 accctgtaca gcaatggttt ttccttcaag agagtcggtt ccgaaagcag ctttagctgc 2334661 tgccttcatt cctctgtaca ccccgtacgc tgtgactggg gacggatttc cagaagagcc 2334721 gaaagcagga gaaatccctg tgacatagtc tgtctcatca tgaatgatat ccatatcctc 2334781 gaccgttgtg cccacatctt cagccgtgat gtatctgcca ttcagtcctt gaatatagcg 2334841 gccaaacgcg cggaacattt cctcattttt gtctttgcgc ggatcgccga taatgactgt 2334901 ttttccgccg ccaaggttta agcctgccgc cgcgttctta taggtcatgc ctcttgccaa 2334961 tctgagcgca tcttcaattg ccgcttcttc attttcatat gtccacattc tcgttccgcc 2335021 aagcgccgga ccaagcgttg tatcatgaat ggcgataatc gcttttaatc cagattgttc 2335081 atcctggcag aataccaatt gttcgtaatc gtatttctcc atatatttaa aaagttccat 2335141 gttcgttcct cctaatgtgt gtattcttca gatgcgcata ttgccagcgc aatggaatac 2335201 agtttatttt cagcagagtc cgctctgctt gttaaagcaa tcggtgcttt tgctcctgta 2335261 atgacagccg ccacgctggc cttggcaaaa taaatcagtg atttatataa aatattgccg 2335321 gcctcaattg ttgggacgag aaggatatct gcgttgcccg ctacgtctcc cgaaattttt 2335381 ttctgggccg cggcaatttg tgaaactgcg ttatccaaag caagcggtcc atcaacaatg 2335441 cagcctttga tctggcccct tttgtacatt tgagctagag cagctgcatt cacggtcgct 2335501 tccattttag ggttcaccgt ttcgaccgct gcaagggcag ctgcttttgg catattgttc 2335561 cccactgcat gggccacatg aacggcattt tgcaaaatct gccggagctc ttccagcgaa 2335621 ggagcaatat tcattgccga atctgtcaca aacatcagcc ggtcaaaatc cggtatatcg 2335681 aagacagcca cgtgagaaag gacacttgct gaccgaagcc cctcctgtct gttcaatacc 2335741 gctttaagca aaacagaagt cggcacattg cctttcatta aaacgtccgc tgttttatga 2335801 tgcacagcac gaaccgctaa tttcgccgat tcctcaggag tattggcatg gacgatttcc 2335861 acttgatgcc cttgcatgga tgatgtcagc tcgttcagtt ttttgctgtc gcccgttaac 2335921 aagaaacggg cggataggtg ctcggctgcc agctttacag cccggatcac ttcctcatcc 2335981 tcagcatgag caaccgcaat ggtcttattt ttgtgtatcg acgctttgcc gattaaatct 2336041 ttcagcttca tctgttacca cctttcttgt ttcgactccg ccttttatta tgcaagttcc 2336101 atgccagctc ttaagggtgc tgtcatacca ggtataccga aacattcgtg cagatgtttg 2336161 cgtttattct gcaaattatt gcatgccttc atttgcaagg ccatatttat ccattttgta 2336221 atataaattc cgaatgctga caccgagagc ttttgctgtt tttgtccggt taaaatgatg 2336281 cttttcaagc gtttgctgga tcaaatgcgc ttcaaatttt tctactgcga cagacagctt 2336341 ttcgccttca atatccggaa aatcaaaacc tgttccctga tctgtgtcat tttctttttg 2336401 ctcaagttcg aatacaggca agtgatcttt ttcaatccat tccatatgcg gattcagaaa 2336461 aatcatggct cgtccaagga cattttcaag ctcccggaca ttcccaggcc aatggtaggc 2336521 agataaggcg cgcaaggctt gctgtgagag cccttttaca ttcctgccgt aatcccggtt 2336581 gatcttttgg ataagtctga cgctcaatgc ttcaatgtcc tccaaccgct gccgcaaagg 2336641 cgggatggag atcggatagc gattgatccg gtaatacagg tcttcccgga atgttccgtc 2336701 cgccatcgcc ttttcaatat ttacatttgt cgccgcgatc actctgacgt tgacagggat 2336761 cgctttcgtg ccgcccactc tgacgatttc cttttcttga aggacgcgta gcaatttggc 2336821 ctgcatattt tgtgtcagct caccgatttc atctaagaaa atactgccgt tatttgcttc 2336881 ctcaaataaa ccctttttac cgccgcgctt cgctcctgaa aacgcaccat cctcatagcc 2336941 gaacaattct gattcgagca ggttttcaga aagggctgca caattcacgc gaataaattt 2337001 attgtatttc cggtcacttt cgttatggat ggcatgggcg aacagttctt ttcctgttcc 2337061 tgattccccg cgcagcaaga tggttgccgg tgttttcgca ccgagcttcg cctgctcaag 2337121 cgcaaccagc atttgctcgc ttttgccgat aatgtcgtca aacgtgtatt tcgcttcaag 2337181 cgtgcgaata atttgtctgg cgcgattaag ctccgctgtc agcattttaa tttcggaaac 2337241 atcgtgaatc acgccgacgc tgcctttcaa aatcccgtcc acaatcaccg gtgctacatt 2337301 aacgatcact tctttttcat tcgggccgac cttcattctg acaccgcgga caggacgtct 2337361 tgtttcaagc acctttaaat gcatgctttc gccttcggaa atatcagtgt ttgcaggctt 2337421 gccgatgact tctttttcag aaagccccgt cattttcgta tacgctttat tgattagcag 2337481 gccgatgccg ttttcatcaa cgacagaaat cgcctcatcg gaggattgaa taattgcctc 2337541 cagcatcgta cggacctgct ttaagttggt cacttcctct gccagctcga ccgcatcagt 2337601 gatatcttta aacacacaaa gagccccgag cagacgtccg ccttcatcaa taatcggcag 2337661 tcttgtggtc acaatttgca aatgatcgcc taacagctgc ttctggttgt attcaggcac 2337721 tcttgttttt aaaatccgcg gcatcttagt gctcggaatc acttctttta ttgggcgccc 2337781 aatgacttcc tcacgttttt ttccgaccat tttttcggcc atatggttaa agagaatgat 2337841 ttcttcattg atatcaataa aaatcattcc atcatgggtg gaattaaaaa ttctgtcata 2337901 tttataggtt tgctctttta gcatttgaat caggtgctgc ttttcttcca tcagctgaaa 2337961 aacgatgtat gccatttttc ccggcatgac aatggtatct tcatgctttc tttgaaggag 2338021 ctcgtcaaac acggcttgat cgccggtagt atgaatgacg atatccggtt tttgttgtat 2338081 gtaaggtttc caatcagatg atacggcaat cccatactgt tctgcttctt tcaatcccgg 2338141 cgcctcgggg tctttgtcaa ctacggcaat gatatctatg atggctgttt taatcagaat 2338201 atgtaataac gccgttcccc ttttgccggc acctactatc agtacctttt gcatcccgat 2338261 acccctttgt atgaaaaaat ttgcacacct atttattccg ttgcaataat ttgcacaacc 2338321 ctatgttacc acgttttctt ctcttgacaa aatatttttt ccgctggaca ataaaggaaa 2338381 tgaaaagata aaggggtttt ctgaagatga gccgacttct tgcgctttta atattagtca 2338441 tccccggggc tatttctgct ttaggcatta aactgatgag agatacactt ttcggccata 2338501 caatcaagcc attttcagct ctttggctcc aagggttgtc aggattcatc ttttttgcga 2338561 tcggcctcta tgtgctggcc gggttcattt tatacagaga cagaaaacgc aatcaagtca 2338621 gcccgcgatt cagaaaacga tagctgaaaa aaagccggag aatgctccgg ctttttttgt 2338681 tgcattattc gtcaggcaaa acggtcttgg caatcgtttt gtctaacgct tcatagtcat 2338741 aataagaaat cgtatcgtac agttcttttc gtgtctgcat atcatgaagt ccttcttttt 2338801 gtgagccgtg ctccttcatc aaaccaaaca tccgctcaca agcttttgcc gccgctcgaa 2338861 gcgaggtgac aggatatatc accatgtgaa accccatatc ttcgaattca tcggcacgat 2338921 aatatggcgt tttcccaaat tcagtcatat tcgcaaggag cggaacgggg atacgctcag 2338981 caaactggcg gaattcattc tccgcctgta gcgcttccgg gaaaattgcg tccgctcccg 2339041 cctcaatgta agcctctgaa cgttttattg cggcatcaag cccttcctgc gccctggcat 2339101 cagtacgggc aacaacaata agggagggtg ccgcttgttt aatggctttt attttttgcg 2339161 ccatttcctt tatcggaact agctgtttgc catttaaatg tccgcatttt tttgggagct 2339221 gctggtcttc catttgaacg gctgctaccc tggcttcaag catctcccgg gctgttcggg 2339281 cggcatttaa gacaccgcca aatcccgtat cgatatccac aagcaaaggc agatcagctg 2339341 cacgcacaag atctttggcc cgttcagcta tctctgccga tgtgatgatc cctaaatcag 2339401 gcagccccct gctggctgta taggcagcac cggacaaata aatagcagaa aaaccggctt 2339461 ctttcgcaag caaagcggcc atcccgtcat gggcgccggg aatttgaaga atgtccggtg 2339521 ctgacatcag cttgcggaaa cgcccggcaa gctcctcttg tgacgattgc ttattgacga 2339581 tccacgacat gaaacaaaat ccccctttta catgcagaac atgtctacga attcatttac 2339641 gcgcatcgtt tgtaatgtct catagctggt acagcgctca taaatgtgtt tgtgctgttt 2339701 atcaggaaaa tgggttttga gattgtcaga aaacttttcc agcagtttcg gcactgcttc 2339761 ctctcttcga aaacgatggc cgaggggaaa ctcacattcc accatttccg tgctcgttcc 2339821 atctttaaaa tgaacctgaa cggcatttga gatggagcgt ttatcaggct tcaaataatc 2339881 ctcggtatat gttttatttt cagtcacttc cattttatca cgaagtttat ctattctcgg 2339941 atcattcgct gtttcagctt cataatgctg tgcggtgata tcaccaaaaa gcaaaccgat 2340001 tgctgtaatg tattggaggc agtgatcacg gtctgccgga ttgtggagcg ggcctttttt 2340061 atcaatgatt cggatagctg attcatgcgt tctgatgaca actcggtcaa tctcgtcaat 2340121 ccggttcttt acctgcgggt gaagaatgac ggcggactcc gccgctgtct gggcgtgaaa 2340181 ttccgcagga taagacactt taaataacac attttccatg acataagcgt cgagcggacg 2340241 ggcaagcttg atctctttct tattgaataa aacgtcttgg aacccccaac ccggtgcact 2340301 caaggctgtc ggataaccca tttccccttt taacgacatc agcgccaaat gaacacctct 2340361 gctcgttgca tctcctgccg cccatgattt acgcgagcct gtattcggtg aatggcggta 2340421 tgtcctcaat gctgcattgt caatccatgc attcgaaagc gcatttttga tttcttctct 2340481 tccgccgccc aaaagctttg ctgcaacagc agttgtcgca actttgacaa acagcacatg 2340541 gtcaaggcca actcgattta agctgttttc taacgccagc acaccttgga tctcgtgtgc 2340601 tttgatcatc atctcaagta cgtcgcgtac cgttaacggc tcttttcctt cagacagcct 2340661 cactcttgat acataatcag cagcggcaag gattcctccc aagttatcgg atggatgccc 2340721 ccactccgcc gccagccacg tatcgttgta atcgagccag cgaatcatgc agccaatatt 2340781 aaacgctgcc ctcacaggat cgagaacata tgacgttccc ggcactttgc ttccattcgg 2340841 cacagtcgtt cctggaacaa tcgggccaag cagctttgtg cattccggat accgtagcgc 2340901 caagattccg cagcccaggg tatccagcaa tacatgcccc gctgttgtat acgcttcggc 2340961 actagtaatc tctttctcaa gcacatagtc tgtgatttct tcgataacac gatccgtttt 2341021 cggcattcta ccagctcctt tcatgatttt gtttgatatc gcgggcccat gtaactgaca 2341081 cggggacgga agagccgatt attggcatgc tgttcgatca catgggcgca taaaccggac 2341141 gttctcgcgc tgaaaaagat cggcgtatat aaaggaatcg gtatgccgag catccaatac 2341201 actggggcag catagtaatc caaattcggg taaagccctt tttccttctc catcagccgc 2341261 tcacccgctt cgcacatctc atataaacga tggtcaccgg ctttatcgca taattgctgc 2341321 agcgcctctt tcatcatgag tgctctcggg tccatttttt tcatatacac ccggtggccg 2341381 aagcccatga ttttttcttt tcttttcagt tttgtttgca aaagctgctc aaaatcagat 2341441 gtcgtttttg cctccaaaag caaatacatc acagcttcgt ttgctcctcc gtgaagattc 2341501 cctttcaggg aagcgacagc cccagtcaaa gccccataaa gatctgaatg tgtagatgca 2341561 atgaccctgg ccgcaaaggt tgaattcggc atctcatgct cactgtacag gacgagcgac 2341621 cggtcaaaaa tctgttcttc caatgaagac ggcaatttcc ctgtcatcat gtagagaaaa 2341681 ttcgcactgt aggatagggt ttgaagcgga agaatcggtt ctttcttatt aatgatcctg 2341741 tagctggcag cagtgagggc aggcattttc ccaagaagct gataggcgcg ttctttgttt 2341801 gcggaaggag accgatcatc aatttgccga tcatagccag caagtgccga caggccggta 2341861 cgcagaccat ccattggatg agtgtcctca gggagcagct caagcagacg gagatgatca 2341921 gcaggcaggc ttgaggcact gtttatttta cgttccagcg tttccatttc actttcttct 2341981 ggcagcctgc cctccagcaa taaatggaca agctccagat agctttttgt ttcagaaagt 2342041 tctattaaat catagcctct tatcaaaatc tggctggact gcgtgtcaag ataagaaata 2342101 tgagtttctg ccgcaatcac accgtccaac cctggagaat aatgctgttt ctcctccata 2342161 tcctcaacct ccgtttttgc gttttttgtc tatcaggttc cgccaagcaa atacttggaa 2342221 ataatcagtc tttgaatctc gttcgtccct tcataaattt gcgtcacctt tgcatcgcga 2342281 agcaggcgct caactggata atccttcata tagccatatc ccccataaat ttgaacggcg 2342341 tctaacgccg cctttacggc tgcatcggaa gcaaattgtt tagccataga cgcttctttt 2342401 ccacagttta ggccgcggtt atgaaggtct gcagcgtggt agacaagatg tcttgccgcc 2342461 tcagctctag tcgccatatc agccagctta aatgatatgc cttgattggc tgcaatcggc 2342521 cttccaaatt gcactcgctg cttcgcataa tcaacggcat gctcaagagc cgcctctgca 2342581 attccgaggg cctgtgccgc aatgccgatc cggccgacat ttaaattcgc catggcaatg 2342641 tgaaagccat ccccctcttt gccaagcaaa ttggcttcag gcacttctgc attatcaaaa 2342701 atcagttccg tagtattgga gccataaagc cccagctttc tttctttttt tccaacggta 2342761 aaaccgggtg tgtttttttc aacaataaaa gccgaaatcc cgtgcctgcc ttgatctgga 2342821 gctgttaaag caaatgtgat atagatatca gctgctccgc cattcgttat gaatattttc 2342881 gatccgttta ataggtattt gccgttcttt ttgattgctg ttgtgcggag gctcccggca 2342941 tccgaccccg agtgaggctc cgttagtgca aatgcgccca aatggtctcc tgacgcgaga 2343001 tttggtatat atttcatctt ctgttcttcg ttgccgaaat acagaatcgg attcgtgccg 2343061 actgaggtat gaacggagag aatcacgccg acagccgcgc tgattctaga aatctcatga 2343121 attgccaaaa tataagaaac aacgtccgct ccagcaccgc cgtattgttc cggcaccggt 2343181 attcccatca gtccgtgttt acccattttt ttgatcagct gaaagggaaa ttcgtccgtt 2343241 ttctccatga tttccgcagc gggagcaatt tcttttcgtg caaaatcacg caccattttt 2343301 cgcatcatga cttgctcttg ggttacatgc aactcggcca cccccggatg gaatagactt 2343361 caggaagtct tctcctcata gtcataaaaa ccgcgtccgc tctttttgcc aagccagcct 2343421 gctttgacat acttgcggag cagcgggcaa ggacggtatt tggaatcgcc aaggcctgag 2343481 tgaaggactt ccataattga taaacacgta tccagtccga taaaatccgc taatgcaagc 2343541 ggacccatcg gatgattcat gcccagcttc atcacttcat ctattgcctc cggcttcgcc 2343601 actccctcat acacgcaata gatggcttca ttaatcattg gaagaagcac acggttggaa 2343661 acaaacccag gaaaatcatt gacttctacc gctgttttcc ccatcttttc cgctaatgcc 2343721 ataacatcta aggccgtttc ttctgatgta gccaagcctc gaatcacttc taccagcttc 2343781 attacaggga cgggattcat aaaatgcatg ccaataaccc gttgaggccg gtttgttaca 2343841 gcagcgattt ctgtaatagg caaggaagat gtattgctgg ccaaaatcgt atgaggcggg 2343901 caaatgcgat caagtgtttt aaacatctca gtttttgccg ccatgttttc tgcgatagcc 2343961 tcaatcacaa tgtccgcatg ctctgcctcc tcaagtgttt gagaaatcga aatgcggttg 2344021 attacgctct tcacttccgt ctcggtcctt tttcctttct cagcatcacg ggccagctgt 2344081 ttcttcagcc gtttcaatcc tgcctccgcg gcctctggat tcacatcata catccgcaca 2344141 taaaagcccg cgtcggcggc tgtttgagca attccgctcc ccatctgacc tgcgccagct 2344201 accatgattt gtttgatttc cattcaaatc ccctttttca tcatgtttta atgaacctgc 2344261 actaagacgg cgtctccctg tgctgccccg ctgcaaatag cggcaacgcc cagaccccct 2344321 ccccgtcgct ttaattcata aacaagcgtc atgagaattc tcgcaccgct cgcgccgatc 2344381 gggtggccga gcgcgatcgc accgccattc acatttactt tttcaagatc gaaacctacg 2344441 attttttcac atgtcaaaac aactgaagca aaagcttcat ttacttcaaa caagtcaata 2344501 tcttggacag ttaaaccatt ctttttcagg agcttgttaa tagcaaaccc tggcgctgcc 2344561 gccagctcgt gcgctggcat tcccgtagtt gaaaaaccaa gaattgtagc cagaggccgt 2344621 ttgccaagct cagcagcttt ttcctcagac atcagcacga acgcgccggc tccgtcattg 2344681 actccaggag cattgccggc tgtgatagaa ccgtcacttg cataaatcgg agcaagtttt 2344741 gcgagctgat ccagacttgt gtcacggcga atcgcttcat ctttatcaac aacgtttggt 2344801 tttccttttc gaccgatcca gttgacggga acaatttcat cctgaaactt cccttcatcg 2344861 gcggccttag ctgcccttgc atgacttctc aacgcccatt cgtcctgctc tcttcgtgag 2344921 attgcatatt ccttggcagc tgtatttccg tgaacagcca tgtgcacctc gtcaaatgcg 2344981 cacgttaatc cgtcatacac cattaagtcc ctaagctcgc cgtcccccat ccgtgctccc 2345041 cagcgcccgg cgggaacggc atacggaata ttgctcatgc tttccatccc ccccgcaaca 2345101 agtatgtccg catcctgcgc ccgaatcatt tgatcacata aagtgacagc gcgaaggccg 2345161 gaagcacaga ctttattcag tgtttctgac ggcacactcc aaggcattcc cgccagacgg 2345221 gcagcttgac gggaaggtat ctgccctgag ccggcctgga caaccatgcc catgacgttt 2345281 ccttctacat catctccaga gactccagcc tgttgcagcg cctccttcat cacaatgccc 2345341 ccaagctcag cagctttcac ctctttcaaa actccgccga atttgccaaa tggagttctt 2345401 gcagcactta caatgactgt tttcctcatg gtttcacctc attcagaaga tagacagcgc 2345461 ttacaatttc tagttgtctt ctatgaatgt atgctttgaa acgggcatga atgaatgaaa 2345521 aaagaaggct gcgtcaaaca gcctccttct aacaactatt catttttcag caatgccgaa 2345581 gccttttctg gaaagtcggt aaacatgccg tctgctcccg cttcaatgag acgcttcata 2345641 tcttccggac gattgactgt atacggcctt accttaatca aaccgttcct cattttcttc 2345701 agtacttcat ctgtgacccc tgggctgttt atcttcgggt gatagccgga agccggaata 2345761 gacgcgatat atcgatctgc ctgataaagc acatctgaag ttaatactgc ccgttcgata 2345821 tgcggtgcaa gccgggcgca cagcgccaag ctgtcatgat taaacgtgga taggatgact 2345881 ctgtcctcta cattaaatcg cttcactgcc tccagcactt tttcttccat tccctcatag 2345941 cggatcacgc tgttttttaa ttcaatgttg atgagaaaat ccttttttac cgcccacgag 2346001 agcacatctt ctagcagcgg cacttttata tcgctgtacg cttgatcgtg accagcggcc 2346061 gcattcgcag tctttacctc atcataggct gtatccttca cgaatccttt aagtgatgtc 2346121 gtgcgattaa gtctttcatc atgaattaca acaatgcgtc cgtctttcgt cagctgtaca 2346181 tcaagctcta tcccatccgc tccggcttca attccttttt caaatgcaag cattgtattt 2346241 tcgggaaatt gacctgatgc cccccggtgg gcaaaaatct ttgtcatcgt ttcacctcaa 2346301 accctaaagt tttctccatt atacttattt tgtcggctcc actctaggat taaggctgta 2346361 tcaatctact gatcataata agaatcaatg ccattgacaa tcgcatctgc ggccttttgc 2346421 tggtattctt cacttcccag cttgtccgcg tcagagctgt tcgtgataaa cccaagctcc 2346481 gccaacacac ttggcatttg tgaatatgta atgacgtaaa agtctgattc tttcacgccc 2346541 ctgtctctcg tttgtaagga agaaacgagc tgtgactgaa tatcggatgc cagacgccgg 2346601 ctgttctccc cttcataatc agattgaaaa tacgtttctg ttcctgaagc tgaagcaacc 2346661 cctgaattca catgaatgct gacaaaaagg tcagcctgat tggcacttgc cttagccact 2346721 ctttcctcca aggtcagaaa atgatcgtca gaccgggatg caacaggatt ggctccctcc 2346781 tcttttagtt tgtctgtcac atgctctgag acagccaaat taatatcctt ttcaaagagc 2346841 ccgtttccga ccgctccact gtcttcaccg ccgtgtccgg catcaatata cactgttttc 2346901 ccttctatcg gctctgctgc ctgtgcacaa ggcgcgagcg tcaaagccaa tccgcacagc 2346961 gccaagctcc tccataacat tctcaactta ctccctccgg tcacgagttc tttcgcagct 2347021 gaatatcttc cagctgtaaa gttccattat ccttctttgt atatttcacc aggacatgtg 2347081 tctgatctgg cagtgattca cattcatcac gtttatcctt cggaacttgt atcatggttt 2347141 cttctccatt aagagaaacc gcaatcgtat gaggatcagc cgagccaatg tattttccct 2347201 cttcggtaaa cctcggcact gagtcatccg cacttgcaac actgcacccc gaaagaaaga 2347261 gcgcagtaaa cagcaaaaga accgtttgtt tcacatgacc acctcttcct gatgtttggc 2347321 ttttatcttt gaccagaatg gagaatttgt aaagacaacg cgaatgcagg cgagcaagtt 2347381 ccatgatttt caaaagggct atacgacccg atcatttcct gttgttagaa agataacgag 2347441 cagatttgtc tatgaggatg gctctaattg aggcgccaat tagaaaaaat tagcggaaag 2347501 aagcaacttt ttattcattt taaaaaattt gagaataggg tgagcaaatc gtttgacggg 2347561 tgggtcagcc aagcgtaacc ttttaaagga tatttacttt attgaaagaa gttaaagcca 2347621 tgaaaaaatt cgttctgctg ctggcggcag ctgtcatcac atgctccatc ggccaccaaa 2347681 tcagtggcgg ctacaaaggc cccgaaaaag agcggccaaa acatcactct gcactcaaga 2347741 tattcagtcg gtaaagcaga tcaattgcat taatttttac atataggcta gaatatgtgc 2347801 gaatccaaac gaaagaagat gatcaaatga atcctaagta taagccactt tttgaaccat 2347861 ttacgtttaa aagcggcgtt acaatcaaca accggatcgc agtagcaccg atgactcatt 2347921 acgcttctaa tgaagacggt acaatatctg aagcggagct cgactacatc atcccccgtt 2347981 caaaagagat gggaatggtg attacagcct gcgcaaatgt tacaccggac ggaaaagcat 2348041 tccccgggca gccggccatc catgacgatt ccaacattcc aggtttaaaa aagttagcac 2348101 aagccattca ggcacaaggc gctaaagctg ttgtacaaat tcatcacggc ggtattgagt 2348161 gcccgtctga gctcgttcct caacaggatg ttgtggggcc aagtgacgtg tttgataacg 2348221 gcaaacaaat tgctcgcgca ttaacagaag aagaagtgga aaacattgtg aaggcgtttg 2348281 gagaagcgac aagacgcgcc attgaagccg gctttgacgg tgtcgaaatt cacggtgcaa 2348341 acggctactt aattcagcag ttttattctc cgaaaaccaa ccagcgcacg gatcgctggg 2348401 gaggaagcga tgaaaaacga ttagccttcc cgctcgctat tgtcgatgaa gtgaaaaaag 2348461 ccgcttcaga acatgcgaag ggtgcattct tagtcggcta ccgcctgtct ccggaagaac 2348521 ctgagacacc gggattgaca atgactgaaa cttatacgct tgttgatgct ttaggggata 2348581 aagaattgga ttatcttcat atctcactga tggacgtgaa ctcaaaagcg cgccgcggtg 2348641 cagatccgac tcgcacacgc atggacttat tgaatgaacg tgtcggaaac aaagtgccgc 2348701 tgatcgccgt cggttccatc cattccgctg atgacgcgct tgccgtcatc gaaaacggta 2348761 ttccactggt cgctatggga cgcgaaattc tagttgaccc taactggacg gtaaaagtaa 2348821 aagaaggccg tgaaaagcaa atcgaaacag tgatcaaagg cacagataaa gaaaaatatc 2348881 atttgcctga accgctatgg caagcaattg tgaacacaca aggctgggtg ccttataaag 2348941 attaatgtgc aaagactgcc gaaacgattc ggcagtcttt tttcccttta tataaatagt 2349001 ttgtgtacac atctaaacag caaaagaaag agctccccac caacttcgaa aagaaaatcc 2349061 aggaaaaacc cctcacgctt tcttgctttt ttctttttca ttcgtacgtc tcctttttac 2349121 atgaatacgc cttacttacg attttgcagg agaaaggttt cattttataa cggacacatc 2349181 tagggtcgat catgcttcgt gatcctataa gatgtatgaa tggaccaaga gtgcaggtaa 2349241 taccgccatt tgctttcctt acttttcaaa cctatccttt actatatgcg gatacttaat 2349301 attcttctcc catactacaa atgtccccaa aacaaaacgc ctcctattta tcagcgcaaa 2349361 ctaataaata aaagacgttt gatttaatga ccacttaata agctcatgtt taagaagcct 2349421 tatgctctaa cctcagctta tccgcaacca ttgcaatgaa ttcactgttg gtaggtttag 2349481 cttttgtcat gctgacagta taaccaaaca acgaggaaat ggaatcaatg tttcctctgc 2349541 tccatgccac ttcaattgca tggcggatcg ctctttctac acggcttgcg gttgtgttaa 2349601 attttttggc gatgtccgga tagaggactt ttgtaatgct gccgagcaat tcgatgtcat 2349661 tgtataccat tgagattgct tcgcgcagat agagatagcc tttaatatgg gctgggacgc 2349721 cgatttcatg gataatgctt gtgatgctcg cgtcgagatt tttcttcttt ggttcaggct 2349781 ggctgctgcg tataatactg ctttgcgatg atggcgcacg atgcgtcaca ctgctggcat 2349841 ttccgctgac ctggcggata tggccgacaa ggttttccat atcaaacggt ttgagaataa 2349901 agtaggacgc gcctaaatcg acggcctttt tcgtgacatc ttcctgccca aaggctgtca 2349961 gcataatgac attcggctgt tttttcagat ctgattccct cagcctctct aaaaccgcaa 2350021 gtccgtctag atgcggcata ataatatcta atacgagcac atcgggatct ttttctttaa 2350081 acagcgacag gcattcctgt ccgttataag caacgccgat cacttccatg tcttcctgtc 2350141 cttctatata ttcacttaac aggcttacca gctctcgatt atcatcagca acacaaactt 2350201 taattttctc cacgtttctt cctccccaaa tgtagttaac aggattcacc cttgctacat 2350261 gtttacattc gacaaaaccg ctatataccc tctaaaaaaa tcataatcac caatattagt 2350321 ggcatatctt tgttattcta tgtttttctc tgtttttcga ctaaaaatga aatttgacaa 2350381 acaaggaaac gtgaatttgt cgaaaaatct tcttttgtat attttaccgt atgtattctg 2350441 agaagtgaag agggatcaaa ataaaaaaac tgccggaaac tccggcagtc agcttgcttt 2350501 ttcttttcca taaatatcga ttcctgcttc tgacagcatc cattcaatat gaacaccgta 2350561 gccgcttgtc gggtcattta caaatacatg ggtgacagca ccgatcactt ttccattttg 2350621 aatgatcggg cttccgctca tcccctgtac gatgcctcct gtttctttca acagtcttgg 2350681 atcggtaatt ttcaacacca ttccttttgt cgcagggaat ttttgcggcg ttgtgctgac 2350741 gatttcaata tcgaattttt ctactttgtc atcatcaata accgttaaaa tttcagccgg 2350801 cccttttttg acttcggtag aaaacgcaac cggcaatgct tgatctgata tgttgttttg 2350861 aatcggctga tgcagtgtgc cgaaaatccc aaacgggctg tttctgttaa tatccccgat 2350921 cgttttgcgt tctgaggaaa atcgcgccag tttttctccc ggattaccgc ctgtcccttt 2350981 ttcaattgat gttacagtgg atttaacgat ttctccattc tccactacaa ttggtttctt 2351041 tgtgtccata tcggaaatca cgtggccaag tgctccgtat ttttttgttt tcggttcata 2351101 aaaggtcata gtgccgatgc cagcagcaga atctctgata tataacccga ttctgtattt 2351161 gccttctcct tcatcctttt ctgggatcag cttcgttttg attttctgtt tatcacgttt 2351221 gatcagtaag tctaaagatt caccagtttt cccagccttt tgaataaatg gggctacatc 2351281 attcattttt tcaattttct gtccattcat ctcaataatg atgtcgcccg cttcaattcc 2351341 tgccgtttct cccggagatt ttttgccttc acttgtattg atttgatgaa atccgacgac 2351401 aagaacaccg acggaatgaa gttttacacc gattgattgt ccgccaggta taacttttaa 2351461 atcaggaaga acatgcactt ttgttttttt aattggaaat ccggcaagat catataccaa 2351521 ttctgactca cctgattttt tgcccgtcac cttgatttca tgcggatctt tctttactgt 2351581 aaacgcttct gaggattctg atgtctgagc gtttaccgat aaactcgttt caatcgcttg 2351641 tgtttgggtt tcaaatactc tcatttgcgt tggaatcagt aaatattctt ttagcggttt 2351701 gcataaacct acacttaata acgaaacaag gagaattaaa cctactgctt ttctgatgtt 2351761 atcgggcatt cactacttca ctctcctcgc tcctatccca caccttcttt atgacttgct 2351821 gctacatcat ttaattttgc cttctgacgg cttatttata actgtcatat gaagaaaaac 2351881 attggatata ctgatgaacg aatggatgtg cacgaaaaaa ataagctgcg cttctcgcgc 2351941 agcttaccca gttgttttga cttgatccgc ttgttttaaa agttctttcg catggcgttt 2352001 cgttaagtcg gttacttcga cacctgcaat catgcgcccg atttccgcta ccttttcctg 2352061 cttagagagc ggcttgacac gtgtcgtcgt tctgccgtct tttaactcct tcgcaatata 2352121 aagatgcgta tcggccatgg cagccacctg aggcaggtgt gtaatgcaca gcacttgtga 2352181 tcctattgac accttatgga tcttctcagc aattgcctgt gcgaccctgc cgcttacacc 2352241 ggtatcaacc tcgtcaaaaa tgatcgatgt cacatcctgt tgtgaggaaa aaatgctttt 2352301 tatggcaagc atcacccgtg acagctctcc acctgaagcg actttcgaaa gggatttcag 2352361 cggctcgcct gtattggttg aaattaaaaa cttcaccagg tcaatccctt gttcagtcag 2352421 ctgaacgggc tggccgttta caagcggcgc ctcttcattg cgtgacgctg ttctgacctt 2352481 aaattccgta tcaaaagttg atttttccat gtacaggctt tttaattccc gatgaatctc 2352541 atcagccagc tttttcgccc atgtttttcg gatttgtgac acatttgccg cttccactgc 2352601 gacatctttg ccgacggagt caagctcctt tttcaagctt tgaaggtggc tgtccctgtt 2352661 ttcaatttgg tcaatctctt cttcaatttt agaagcatat tccaaaatgt cttcaacagt 2352721 ggcaccgtat tttcgtttca gctgtttgat ttcattaagt cgcgtctcaa tatagttcag 2352781 gcgttccgga tcaaattcaa gctcatccag catatttctc atctgaaatg tggcatcctc 2352841 aagcaaatag taggagttcg aaacactttc agacattttt ttcagcggtt cgtttatatc 2352901 agatatatct tcaagctgcg ctgatgccat tccaacccag tccaatccgc cctgctcact 2352961 gcgaagcgcg ttatatgcat tttgcagcga ctcatatatc ttctcaaagt ttgaaatttg 2353021 ctggcgctct tcttggagct gttcatcttc gttaagctca agctttgccg attcgatttc 2353081 ttcgagctga aattgaataa gatcaagacg atgggccatt tcctgttcgc tttcagaaag 2353141 ctgcttaagc tttttgagca gcttcacata ccgctggtac ccttcctgat acgttttgag 2353201 cgcgctttcc acttcggccc cggcaaactt gtccaaaagc tggagatgat tttcgtcttc 2353261 cattaacagc tggttatcgt gctgcccgtg aatatctaat aaaagcctgc cgatctctct 2353321 tagtgaagca atcgtgacaa gcttgccatt gacacggcaa acgcttttcc cgctcgtgct 2353381 gatatccctt ctcatgacga tcatttcgtc tgaaacgtcg attccctgct cagcgcatac 2353441 gcctaaaaca ggatggccgc tctccaacag aaacagccct tcaagttcgg cttttgcttc 2353501 cccatatcta acaaattcag atgatccgcg gcctccgact aaaagagaaa tggcatctat 2353561 gatgatggat ttgccggctc cggtttctcc tgttaaaacc gtaagcccgc gttcaaaaga 2353621 aaccgtcagt tcctcaataa tggcaaagtt tttaatcgat agttcagcta acaaacagca 2353681 ttacacctct tatctttgtt agattttctg ttacagcagt tcaaggagcc tgttttttac 2353741 gccttctgta tcttcaggag tccggcaaat aattaaaatc gtatcatctc cgcaaatggt 2353801 ccccatcatt tcatcccagt ccaaattgtc catcagcgcc ccgattgcct gggcattgcc 2353861 cggcatcgtt ttcagcacaa tcatatggct tgctgagtct attttcacaa atgcgtccat 2353921 caatgcccgc tttagctttg acagcggatt gaaacgctgg tccgccggaa gactgtattt 2353981 gtaagaacca ttatttgtag gcacttttac aaggtgaagt tctttaatat cccgtgatac 2354041 cgtggcctgc gttactttgt atccatcctg ctttagcatg tcgaccaatt catcctgcgt 2354101 ttcgatttca ttgcttgtaa tgatctctct gattttaata tgcctctggc ctttgttcat 2354161 gtaagcacct ctatttccaa gcttatctgt tcttttatgt tatatgattc tctgcacatt 2354221 gtacatgaat gcagaaaaaa ggaataatag cgccctatta ttccggtaca tctgcttttt 2354281 tttcttttaa cgtcttatgt gcttcttcta caacgcgcat gatctcttct tccggcagtt 2354341 cctggccttc ctgtccctct cccggccaat gcaaatgaag gagaaactca atatttccgt 2354401 ctcctcccgt gattggagaa aatgacaagc ctttacagat atagccttca gcggcagaaa 2354461 aactgatcat tcgcttgagc acatcagcat gcactttagg atctctaaca atcccttttt 2354521 tgccgacgga ttcccgtccc gcttcaaact gaggcttaac taaagccatg cagtcgctgc 2354581 ccggtacgag caaagtcctt aggacaggca ggatgagccg cagtgaaata aaggacacat 2354641 caattgtggc aaactccggc atgccctttg taaagtctgc cggtgttgca taacgaaagt 2354701 tcgtccgttc catcacgacg acccgttcat cctgtctaag cttccatgca agctgattat 2354761 agcctacatc cacagcgtat gactgtttag ctccattttg caaagcgcag tccgtaaaac 2354821 cgccggtgga ggagccaata tcaatcataa ttttatcttt gacagagacg ggaaattcct 2354881 tcaacgcttt ttcgagcttt aagccgcccc tgctcacata cctcagcggg tttcctttga 2354941 cagttaacgg aaggtcgcgg tcaatttttt ctccaggctt gtccaagcgg ttttcgtttg 2355001 aatagacgat ccccgccata atggctcttt tggctttttc acgcgtttcc gccagccctc 2355061 tttccactaa taatacatct aatcgttctt tctttgacgt catgatccaa ttcctttgtg 2355121 tgtctttggt ggcatcagta atctaatacg atttgccacc tgctgttttg tcagtccaat 2355181 ttcctcaaga agcgctgtta cacttccgtg ttcaataaac cgatcaggta tacccattct 2355241 gtcaatcgga gtatgatatt caccttgatc atgagcgaat tctaaaatcg agcttccgaa 2355301 accgccttct aagaccgctt cttcaattgt taaaattggc aagccttctt ttaggatact 2355361 cttcatcatc ttttcatcaa tcggcttaat aaaacgcgca ttcacaacgc gcacggaaag 2355421 gccttctttc tgcagctctt cggctgcttc aatcgccatt tcgattgttg tgccgaatgt 2355481 taagatgaca gcatcgttcc ctggacgcag cacctcccac gtaccgatcg gaatcgtttt 2355541 caactgttca tccattttta cgccgagtcc gtttccgcgc ggaaaacgca ttgctatcgg 2355601 gccttcgtca tagctaagtg ctgtatgaac catgtgctgg ccttcatttt cgtctttcgg 2355661 catcattaag accatgtttg gaatgtggcg cataaacgca atatcaaaca cgccttgatg 2355721 tgtctctcca tcagcgccaa cgagtccagc acggtcaatt ccaataaaca cattagcgtt 2355781 ttggcggcag atgtcatgaa caacttggtc atatgccctt tgcaggaagg ttgagtaaat 2355841 cgccaaaaac ggcttcatac cctgcattgc catagctgca gccattgttg cggcatgctg 2355901 ttctgcgatt cctacgtcga acatccggtc agggaattcc tttgcgaagc cttcaagctt 2355961 tgaaccgaca ggcatagccg gcgtaatggc tacaatgcgt ccgtcctcgc gcgccattcg 2356021 ctgcacagtt ccgctgacaa gaccgctcca cgaaggagct gcggctttcg gctttacaaa 2356081 gtcaccggta ttaattttat atggtccggt accatgccat gtcccaatcg tatcggtctc 2356141 agccggtttg taccccttcc cttttttcgt aatgacgtgc agaagaacag ggcctttcgt 2356201 ttttttggcg tattgaagat tctcaatcag ctcatgataa gaatgtccgt ccactgggcc 2356261 caaatacgta aaaccgagct cctcgaaaaa cattccggag acgagcatgt atttcaggct 2356321 gtctttgacc cgttccgccg tggcggcaag cttgccccca actgccggaa tctttttaaa 2356381 taagtattca agctcatctt tgacccactg gtatttcccc gcagtgcgga gccgtccgag 2356441 catagagtga atggcaccga cgtttggcgc aatactcatt tcattatcat taaggatgac 2356501 aatcatgtct tttttctcgt cgccgatgtg gttaagggct tcgagcgcca taccgccggt 2356561 cagcgcgccg tcaccaatga tcggaataat atattcatcc gttcctttaa tatcacgggc 2356621 agctgccatt cccatcgcgc ctgacagaga agtcgagctg tgcccggttt cccaaacatc 2356681 gtgctcgctt tcactccgct ttggaaatcc gcaaagccct ttgtactggc gaagcgtcgc 2356741 aaattctttt ccgcgtcctg tcagcagctt atggacatac gactgatggc ctacatccca 2356801 taaaaatttg tctttcgggc tgttaaattc cttatgcagg gcaacagtaa gctctacgac 2356861 acctaagttt gggccgatgt ggccgccgga agcggataaa cttgtaatta aaaactgacg 2356921 gatttcatca cttaatttct ctaattcatc aatggacatg ttttttaaaa acgacgggtc 2356981 ctgtattgat aaaagatcca aagcggatca actcactttc agcatgaatt tctgcaatga 2357041 tacatgtctt ttgcatgccg agctgacaat aatctcagac ataaaaaaag acaaacgcgc 2357101 ttttcctttt catttttcat ataaactgct tacattttac catacctcgt gcagccgctt 2357161 caaattagga tcgttttagt gatctcttgc cgcaattaaa tcacaaagct catataaaag 2357221 gtctttttga agagagagtc cgccgatcaa tcgcttcgcc tcttttatat gaacatccaa 2357281 tttatgtttg gccccttcca atgaaagaag cgacgggtat gtcgatttgt catttgtggt 2357341 atccgagccg acacgtttgc cgattttctc ttcactgcct tctaaatcta aaatatcgtc 2357401 tctgatttga aatccgattc caatgtggct gctgaaggta cgcagtgttt caatgtcttc 2357461 ctcaggcgca tcagccaaaa tagcaccggc gattacacaa aagccaagga gcttggcagt 2357521 tttccgttca tgaatggatt cgagctcttc aagcgtgact tgtcggtttt ccgcttccat 2357581 atcagctact tgcccaccga ccatgccttc ggtgcctgcc gctgaaatca gttcattcac 2357641 aagccgcagg cgcttttctg ctgacacctc gtctgacacg tgggaggtaa tcagcttaaa 2357701 gctttctgtg agcagcccgt cacccgctaa tactgccgtc gcttcaccaa acactttatg 2357761 gtttgtcggc ttcccgcggc gcaaatcgtc atcatccatg catggaagat catcatgaat 2357821 taacgaatac gtgtgaatca tttcgacagc acagcccacc ggaatgccgt ctttttcgct 2357881 ttttccatat gcatttaaaa cagccagtac aatcagaggc cgcaaccgct ttccgccggc 2357941 ctgtagagaa tatagcatag atttctttaa tgagtccggc atatcaagct tttctgtata 2358001 gacagaaagc tgattttcaa ttgttttttt ccggtccgcc agaaagctcg ttaatttatt 2358061 tgtcaccttc gtcttcctcc tgaacactga aaggtgccag ttcgccgtct tcttttaaaa 2358121 tgaagtccat ttgcttttcg actttttgca gcttttcatg gcacattttt gacagagcca 2358181 tgccttcttg gaaatagtta atggcttgct ctagaggcac atctccctct tcaagctttg 2358241 atacaatgct ctcaagccct ttcatcgctt cttcaaatgt catgttttca ttttttttca 2358301 cgtctgtcat ttttcttccc ctctcttttc taatacttca caggtcagca cgccatcctt 2358361 cagcttgatt tcaagccggt cctgctcttc tatttgactg acacttttaa tgagtttatc 2358421 ttctttataa gccaagctgt atcctctttc catcacttga agaggactta gtgcattcag 2358481 cttgccaaga acggtttgaa attgggaatg cagctgcttc atttggatat tcatattttt 2358541 tctcagctga tttgtttgtt cctggtatcg tgttctcgct tgtttcagct gttcatgagg 2358601 atgcaatgcc tctaatctgt acgtttcacg ctccagctgt ctgcttttcc gatctaaaag 2358661 agcggtcagc tgtgcttgaa actgctggta cgcgaggtca aactgctgct ctttttgcgc 2358721 atacaaacgc tttggaaaac gaaaggcata ggacgattgc agcgtttgta tccgttcttt 2358781 tttctggccg agatgctgct gcattgctct tgtcattctg acttccgctg tttttgtccg 2358841 ttcgattaaa tcagtggtat gaggcacagc aatctcagct gctcctgtcg gcgtcgcagc 2358901 tctgatatcg gcgacaaaat cactaatcgt aaaatccgtc tcatgtccga ctgccgatat 2358961 aatcggaata ttggaagcaa agatggcgcg tgctacaatt tcttcattga atgcccacag 2359021 ttcttctatc gaaccgccgc ctctcccgac aattaatacg tcgcaaatct ctttttcatt 2359081 tgcctcttca atgcgcgtaa cgatggatct gctcgcattt tcaccttgta cgagcgctgg 2359141 aagaacaatg acttttacaa ggggatatct tctttttaga gttgtaataa cgtctctgac 2359201 agcggcaccc gttggagatg tcacaacccc gattgtggct ggaaatgcgg ggatttgttt 2359261 tttgtagcgg tcgtcaaata aaccttctcc ggcaagcttc ttttttaatt cttcgtacgc 2359321 taaataaagc gctccaaccc cgtcaggctg catttctttg gcatataatt gatagtttcc 2359381 gctcggttca tatacggaaa ttccgcctct gaccagcact ttcattccgt tttcaggttt 2359441 aaaaggcaga cgctcgcttt gtctcgcgaa catcaccgac tgcattcttg cgttttcgtc 2359501 ttttaaagtg aaataaatat gccctcgtgt gtgtatcttt acattcgaca attcgccttt 2359561 aatccaaata ttttcaaggt gaggatctac atcgaatttt cgttttatat actttgtcag 2359621 cgctgagacg gtcacatacg ctgcttcacc catgtctaaa aactcctctc ctaagcattc 2359681 ctgcaccata actaaagaaa acccgccctg gctttaggag cctgaagaag cgggtatcgt 2359741 gctcatattc aaggcgggta aacatttcgc ctgtgaatat ctccaattat ctatgataac 2359801 gtacgtttcg cagatttaac agtattatgc gcaagcatcg tgatggtcat cggacctact 2359861 ccgcccggaa ccggcgttat gaaggacgct ttttcctttg ccccttcaaa ttcaacgtct 2359921 ccgcaaagct ttccgttttc cagacggtta acgccgacgt caatgacaac agcgccctct 2359981 ttgatctggt ctgcactgat gaagttggct ctgccgactg ccaccaccag gatgtccgct 2360041 tttttcgtat gttcagtaat attttctgtt cttgaatgac agtaagtaac cgtcgcgttt 2360101 tcatttaata aaagctggcc gacaggtttg ccgacaatgt tgcttcggcc gactacaaca 2360161 acctctttac cggaaaggtc aatattggtt ttcttcaaaa gctcaacaat tccatgaggc 2360221 gtgcaaggaa gaaacgtatc ttcgccaagc agcattttcc ctacgtttaa cggatgaaaa 2360281 ccgtctacat ctttatcagg ggagatacgt tcgatcaccg ctttttcaga aatatggtct 2360341 gggagcggaa gctgaacgag aatgccatga aactcagggt cttggttata ttgatcaata 2360401 atggaaagca gttcagcttc tgtgaggctg ctgtcaaatt gatcgagctt gaaattcatt 2360461 cccattgttt ctgccgcttt tttctttcct cgcacgtaag agtgagaagc aggatcatct 2360521 ccaatcaaaa taaccgccag tccgggagtg acgccttgct ttttaagctc ttctacctct 2360581 tttgccaatt gttcgcgttt ttctctagcc gtttcttttc cgtcgatgat tgttgcagtc 2360641 attttctttc ctcctatgat tgttcaatat cagatttaat gttagaaaga accccgttta 2360701 caaactttgt cgctttgtca tcaccaaacc gttttgccag ctcaatcgct tcgttcatgg 2360761 agacattcac cggaatgtct tcggcatatg ccatttcata tgctgccagg cgcaaaatcg 2360821 cacggtcaac attggcaatc cgatcgagct tccaattcac cagatgcttg gagatcattt 2360881 catccagctg gtcttggtgt tccaataccc cgtgtacaag ctgttcaaag aaaggatctg 2360941 ttttttcttc atccagtgcg tgttctatgg cttcattcac tgcaatatcg ctgacatcaa 2361001 tttgaaatag tgcctgcaaa gctttttctc ttgctgttct tcttttcatt ttctttctcc 2361061 tttgatcctc tttatccgct tgtcgttaag ccacaaagag atcataacat atttttttcg 2361121 tatccgcata ttgaaatcaa ggttttttta ccctattacc gaatattttc acacacctta 2361181 atatgattat tcggatttca cgttcatgaa gaaactcggc tatgtaagcc ggctttcttc 2361241 atgctttgaa ataaagggta acgtgtaaaa aaaccaaagg gccgccctcc ccttggtttc 2361301 gtgttaagcc atttacattt cttcgtcgat ttggacttct tgggcttttg tgtcaaattg 2361361 aatgccgacg atgtgaatat tgatctcgtt aatcgaaaga gacgtcatat ttaataaggt 2361421 ttgacgaatg ttttcctgaa cggatgctgc aactttcgga atcgaaacgc caaatgtaac 2361481 gacacagtat acatcgatcg taattccgtc atccgccagg tcgactttga cacctttgcc 2361541 atgattcact ttgccaaagc gctcaacgac gcctgtcgca aagtttccgc gcatttcggc 2361601 aactccatca acttctgatg ctgcaatgcc ggcaatgacc tcaatgacct ccggtgcaat 2361661 ctcaacctta cccaaatgcg tatcttcgtg atccatttta agcaagctgt tgtctttcat 2361721 tcaattcacc tccgtaaaaa ttatgagccc attacatcat atgtttctaa aaatttcgta 2361781 ttaaactctc cgctcacaaa tgtttcgtgt tcaagcagtt ttaaatggaa agggattgtt 2361841 gtctcaatgc cttcgatgac gaattcgctc aatgcgcgct tcatgcgggc aatcgcttca 2361901 tctctcgttt ttccgtatgt gattaccttt gcaatcatgc tgtcatagta cggtgggatg 2361961 gaatagccag ggtacgcagc tgaatcgaca cggacaccaa gaccgccagg aggcaggtac 2362021 attttaattt caccaggtga cggcatgaaa tttttgcttg ggttttctgc gttgattcgg 2362081 cattcgatgg cccagccttc aaattcaaca tcttcttgct tgaggctcag ttccattcct 2362141 gaagccactt tgatttgttc cttgatcagg tcagttcccg tcaccatttc tgtgactggg 2362201 tgctccacct ggattctcgt gttcatttcc atgaagtaat agcgctgttc attgtagtca 2362261 tagataaatt caactgttcc agcacctgta tagccaaccg ctttggcagc ctttaccgct 2362321 gcatctccca tttgctccct gatttctgaa tcaagggcag gagatggtga ttcttccaaa 2362381 agcttttgca ggcgtctttg gatcgagcag tcgcgttcgc ccaaatggat cgtatttccg 2362441 tagttatcag caagcacttg gatctcaacg tggcgaaaat cttctatgta tttttcgatg 2362501 tatacacctg gattcccaaa tgcagttgcc gcttcctgct gtgtaatctt aatgccatta 2362561 atcagttcct cttcagtgcg ggcaacccta attccttttc cgcctccgcc tgcggtggct 2362621 tttataatta caggataccc aatttcatta gcaagcgaaa ccgcttcttc cacattttct 2362681 ataattccct gtgaacccgg tacgattggc acgccggcct gtttcatcgt ttcccgcgca 2362741 acgtcttttg ttcccatttt tgaaatggcg tcagcgctcg ggccgacaaa cgtgacattc 2362801 acttcttcac ataattcagc gaaatcagca ttttcagcta aaaatccgta tcccggatga 2362861 atggcgtccg tgccagtcag ctttgcaaca ctcacaatat ttgtaacgtt taaatagctg 2362921 tcttttgatg ctttcggtcc gatacaaaaa gcttcatcgg ccatttgaac atgaagggca 2362981 tctttatcag cttctgaata aacagcgaca gtctcaattc cgagctctct gcaggctctg 2363041 atgattctga cagcaatttc tcctctgttg gcgatcaata gctttttaat catgttcagt 2363101 ctccttactc cgcttttaca agaaatagag gttgtccgta ttcgaccagc tggccgtttt 2363161 ctactaatac ttcaacgatt tcgcctttca cttctgcttc gatttcgttg aaaagcttca 2363221 tcgcttctac aatgcagaca actgtgtttt catttacttt tgaaccggct gttacatacg 2363281 ggccagcttc cggtgatgaa gaagcataaa atgttcctac cattggtgaa gtgattttat 2363341 gcagattctc atcttgcttt ggtgcttctt gggcaggtgc cgctgcttgc tgcgcttgcg 2363401 gctgaactgc ctgcggagcc tgtgcttgta caggtgctgc cggtgcctgc tgcatgactt 2363461 gaaccgtgcc tgcttcgtgt tttttcagtt ttaaggatac accttcattt tcatatacga 2363521 attcgtcaat tgtagactcg tcaattgctt taatcagctc gtggatttct ttgatattta 2363581 acattcaatc gcactcctat gtatgaaatt tcttttttta taggttacta ctaaaagtac 2363641 atactatgtt catcttacag gagcggactt ttgaattcaa ctctaatatg acagcaacgc 2363701 aaaaagcccg cttgtttagc gggctttttt ccctcattct tatttagagg gttcaaatgt 2363761 gacagcgaca tctttcattg ttttgatttc ttttgccaca aggtctataa tggctgtcgc 2363821 cttcgattta gagtgtttgt ctgatttgac tgtaatattg attttatctc cttcagcatt 2363881 aacaagcgca tcctcgtaac cttgtgtttt aatcagcgtt tccagctgtt tttctgttcc 2363941 ttccacttca ctgagagccg tcattttatc gtatgcttcg cttttctcct tggctgttgc 2364001 atcatcgctt gacacaatgg cattcagctc ttctctttct ttgcttctgg catcttctaa 2364061 atcaagacgg tacgttgtaa acaaatcatc atcggctgtt tccgtaacaa cagttccttt 2364121 ttcactggct tcagcggatg tttccttgtc tgctgatgaa tctttcgttc cctttgttcc 2364181 atcttctttt cctttttcag tttctgtacc gcttttttcc ttcgtgtctt gcttggcagg 2364241 cgctttttca gttgcgacct ctccgctgtc agacgcgctt ttttcacttt gcatctgcac 2364301 ggcgtttttg ctttccggcg acatgatata gtagacgctt aacaccacga caagactgag 2364361 cattgttaat agccaaacgg tttgtttttt aagcatttat gaatcctcct ttattttttt 2364421 aggggcaacc gcaacccggt ggcttggaac atccaggacc cgtgtcaccg cttcgataat 2364481 ggtttgtttt atttgaacgt tgtccactcc ttgagcaaca acgagtacac cgcgtatatc 2364541 aggttttttc gtttggacga cgacaggtgt ttctttatcg ccgtttttga tcatgacgat 2364601 ttcttcctcc gatgattggt ctgtaacgct tctttttccg ccttctttgt cagtttcttc 2364661 agtggttgta tttttgtttg atttgttttt ttcgtatact ttcagcgacg ttgcatctac 2364721 attcacgaca accgagacat cgtccacacc aatgattgtt tcaagaattt ctttcagttg 2364781 attttcgtat tctttttcat agtcatcgat cgagtcttta ggtttatcag attttgaggc 2364841 tttaaacact tcggctgttt tctctttgct gtctgcggaa tgttgtgatg atacggccgt 2364901 tatcgttttg gcgttttcag ttttctcagg tgaagaaaac agctggctga caagcataaa 2364961 ggaaactccg agaacaaaaa cgaatagaaa gtaatgatat ttggtcagct tcggcttttc 2365021 gccgtccttc gtttgtcccg gaagaaactg ctttttcaat acattccata atccgttttt 2365081 attcattgcc gacactctcc ccgccttcca tatgaaccgt aattttctca cttccgattt 2365141 cccaaatgtc cgcgagctgc gtttgtatct gtttggcttc tttttgttcg gctgcttctt 2365201 ttgttacgta tgcatgatct gtatcaatgt ggaccggcgc gaccgtttgg accgtttttt 2365261 cagaagacgg ggccatatac acgctgattg ttttaatatc ctcttctgaa tctacctttt 2365321 ctcctgccgt gagtttgatg cggcctactt tatattcatc atgactgaat ctctcctccg 2365381 ctttcttttt tagttggaca gccatttctt ctagaatata tgcgcgctgg gaagcttgta 2365441 tttctatttt ttttgaattg atttgatttt ttatgtcggc agactctgac tgcccgtttt 2365501 ttgtgaggta ttcaaagatg acttcggggt ctgtcttgaa aagtttaaaa atcggcgtaa 2365561 gcatgacgac aatcaagagc aggctgacta ccatttttgc gtacttttgc atgctggagc 2365621 tcggcagcag catatcaatc acaattgcaa ataggataaa caacacgatg gtggtaagcc 2365681 attccgttaa aaaactcatt tgcctgcctc cttcatttca tcatcatcgt gaggtttccg 2365741 gctgtgatta tgacagtaag gcttaaaaaa aacatgagag acacaatggc gagagctgca 2365801 aaaatataaa tgacgctttt gctgatgacg tcgaggcagg tgatgacggg cccgcctcct 2365861 agcggctgaa gaatcgcggc tgccagctta taaataaaag cgagggaaag cactttgatt 2365921 gccggaaatg ccgcaataca gatcaaaata gcgacaccga gaatccctac cgtatttttc 2365981 agcagtaaag aggcgctgat tactgtatct gttgcgtctg taaacattcg gccaagcaca 2366041 ggaataaaat ttccggttat aaatttagcc gtcctgagcg taatgccgtc tgtcactgca 2366101 gctgacgctc cctgaacaga gatgacgccg agaaagatgg taagaaaaac agccagtgct 2366161 ccgatggcga tatttctgag caggttagcc agctgcgtta ctttgtattg ttcagtcatc 2366221 gtgctgacaa tgctcagaat cgctgataaa aaaatcagcg gcatgacgat attctgaatc 2366281 aagagaccgc tcgtgttcat caggaagagg ataacaggat gaaagaaggc agcagataca 2366341 gctccgcctg aggaagccaa aagcgccaag aggagcggaa tgagcgccag gataaagctg 2366401 gtcatcgtct gaatcgcctc agttgcatag ttaattgcca catgaaagct attaagcgca 2366461 aggataatca gcaccatgta cacaattgag taagcgacct tactgacggt gctttgctga 2366521 aaagcatttt gcaaaagctg cagaatgacg caaaaaatcg tgagcaaaat caatgtgccc 2366581 agcagctttc cgttggcaag cacttcatga aacaaataag aaaagagagc tttcagccat 2366641 tcttgcggtg agaatgattt atcgccattg ataaactcca ttaagctgcc tttttggctt 2366701 tccggcagca gtccgccgta ttctgtcata atgtcattcc aaaattcccc gatcttatct 2366761 gtttcaagcg aggctgctgt cctttccgct aattgctcgg ctgtttcagc atggtcttcc 2366821 gtttgttctg cattaccagc tgcttgtaca atttctgcac ggcctgctat gatcagcacg 2366881 gccaaaagca aaacccattg aaagcgcttc aatctaccgc ctcctttcgg ttatgacata 2366941 gaaggtataa gtccgagaat cgtttcgata atgacggtta aaataggcac agccattacg 2367001 agtattaaaa ttttccccgc caattctatt ttcgaggcga tggctccttg accggcatct 2367061 tttgtgagct gtgccccgaa ttcagcaata taggcgattc cgataatctt taaaatggtt 2367121 tcaacataga ccatgttgac atttgcatta atcgcaattt tttctatcat tcgaataatg 2367181 tcgtagattt ggtctaccaa ataaagaaaa atggcacatc cggcaaaaac gacgattaaa 2367241 aacgcaaaag tcggcttttg ttcttttaca attaaagaaa ggaaggtggc gatcagccct 2367301 aaacctacaa tttgaacaat gtcaatctgc aagcccccct atccttggaa taaaaacaca 2367361 gcttttatct ttttaaatag gtcatctaca atcgtggcga ccataaataa aatatagata 2367421 aaacctaaca gcgtcaccca ctgagcatat tctttcttgc ccatctgatc caatatcgtg 2367481 tgtaaaaaag cgaccacgat tcccactccg gcgatttgaa atatgacatt cacgtctact 2367541 cccattttat ttttgctccc ctcacgttta catcaataga agaatgagta acaagcccgc 2367601 taaaaagccc aaacttttta tcatcttttc gtttttcgct tgcgcctgct cagcatccgc 2367661 ttctgaggct tccaaatgtg tcagcgccag cttgatgtgc ttttgctgag agattcgatc 2367721 atgaatccca agcgtctcgc caaactgctt cagcacttcg tattcgcttt ttttcaaaga 2367781 cagggtgtcc cataccttct ttaagctttg ctcccacgcc gttttcgcgg aatcacttcc 2367841 cttgtccagc tgatcactga atgcggaaaa aagagttgaa acaggctgtg cgagctgttt 2367901 ggcaatctgc tgtgaagcag tatgaagcgg tgtatggccg tacatgattt cagcctcgag 2367961 ggattgaagc gccgcacgca gctggcggat ttgccgcggc cgttctgtat aaatcttcgc 2368021 catctcaaaa cctgtccatg ttgtcgctac cacaatgaat acagcgccca gcagcttcag 2368081 catgttttca cgcccgtcgt cctagacagc acatttccgt ctttgtcata aatttggctc 2368141 actgtgcccg gcccttttgc tcttgataat tccaaatagc ggtcaaaggc tctttcttcc 2368201 cacaaacgct tcaatgaagg ccgcttcatc aggtcggata tactccagcc atgcgccgat 2368261 acgattactg aaacaccggc atgcagcgcc tccagaagtg catctgtatc ttccatacgc 2368321 ccgatttcat cgacaatcat cacctcaggg ctcatggatc gaatcatcat catcagccct 2368381 tcagcttttg gacaggcgtc taacacgtca attctctgac caaattgatg ctgcggaata 2368441 ccgcgaagac atccggcaat ctctgaccgt tcatcgacga tccctgtctt tacgggcagc 2368501 atgttttttt tgccggtgct tgagagcctc gcaaggtccc ggagaagtgt tgttttgccg 2368561 gtttggggcg gtccgataat cagcgtattc agccagctgt tttgatataa gtatggaagc 2368621 agcggctccg caatccccag cttttgccgg gcaattcgta tattaaaaga tgcgatgtca 2368681 cggaggcctt tcacacctcc gttttccgta atgactctgc ccgccagtcc gactctgtgg 2368741 ccgcctctga tcgtgacata ccctttcttc agctcttctt caagtgtata catactatag 2368801 ttgctgagcc ggctcaggat cagatgggca tcctcggccg tgcccgcata ggacaaataa 2368861 acaggttgtc ctcttcgaat caattcaaca gggcggttga tccgaattct gacttcttcg 2368921 atttccagcc attgttgttc cggtatttca gaaagggcgt ttttcatgga ttcagggaga 2368981 acctcagcga tttcattcaa cagagcctcc tcctttctac cgattggctt ctttaaaatg 2369041 tatgatgtga ggcagacttt atgacaagcc tctctttatt tatgaacacc cgccaaaatc 2369101 aagacaacac ccgtaaaaat cagaatcagc tttgcatacg aaagctgccc ggcaatttgg 2369161 tagattccga cagtcattgt aatgataaaa atcaacggac cgacaatagc gagaatgctg 2369221 ttaaccacaa ccgccttccg gacatcgttg gtcacaagca tgacaattgc tgccgtcagc 2369281 tcaatcatag aggataaaac tcgtaatccc gccattgtta aaacagtaga attgatattt 2369341 ccaagtaaaa atttcatagc actctcccaa cctcccattt ttttatatga tatgctctag 2369401 cttgctgaag tagtcttgtc attttcgtat aaaagaaaga ttctgttttt gggcacaaaa 2369461 aaagcctgct cccatttggg aacagacttc tttttttctt tctatgctct tgaaacgtaa 2369521 gaaccgtctg atgtattgac aacaagtgtg tcgccttcat tcacaaagaa cggcacgttt 2369581 acaacaagcc cggtttcagt tttcgcaggt tttgtaccgc ctgacgctgt atcaccttta 2369641 ataccaggtt cagtttcaac aactttcagc tcaactgtgt ttggaagttc gataccaagt 2369701 gtttcatcct ggtacatcat gatatgcaca gacatgtttt ctagcaggta ttttaattct 2369761 tcttcgattt gagttgcgct cagttcaagc tgctcataag aagaagtatc cataaatacg 2369821 tgctgatctc cgtttgcata tagatattgc attgttttgg tttcgatttg cgctttcgct 2369881 actttttcac cagcgcggaa tgttttttcc tgaatcgcgc cagtgcgaag gttgcggagt 2369941 ttagagcgga caaatgccgc accttttcca ggttttacgt gctggaagtc aacgacgcgc 2370001 caaatgccgc catctacttc aattgttaat cctgtacgga aatcgttaac tgaaatcatg 2370061 tttaatgtcc tcctatattc caatcacaaa ataataagtt cttttgggga atgggtgatt 2370121 gtccggttgc cgttttctgt aatcacgatg tcatcttcaa tgcggacacc gcctgtttct 2370181 ggtatgtaaa tgcccggctc cactgtgacc accatacccg gttcaaggat agctgaagat 2370241 ctgacggata atcccggcga ttcatgaact tccatgccga gcccgtgccc ggttgaatgg 2370301 ccgaaatagt caccgtagcc ttttgcagca atatgatccc ttgtgagggc gtcagcctct 2370361 tttcctgtca ttcccggctt aatatgtgcg acgccaagcg cctgagcatc aaatacaacc 2370421 tgatagatct ccttcaattg atcactgggc tgacctacag cgaccgtccg ggtaatatca 2370481 gaacaatatc ctttataata agcgccaaaa tcaagcgtaa caaggtctcc gctttcaatc 2370541 agtttgtcac tggccacacc gtgcggaagg cttgaacgaa ggcctgaggc gacaatcata 2370601 tcaaaagaag agctgtctgc tccctggctt ctcatataaa actccagctc attggcaaca 2370661 gcgatttcag aaatgccggg tttcataaac gtcaagatat gtctgaaggc atcatctgca 2370721 atcttcgcag cttcctctaa tatcttaatc tcttcactag acttaatcaa gcgcaacttt 2370781 tccacggatt cagccacagg cactaattcg gcatcactga taacggcgct gtatgaagcg 2370841 taagtgccat atgtcatgct gttctgttca aagccgagac gcttgatgcc aaacgattca 2370901 acagtgtcgg cagtggtctg aatcaagctg ccgccatgtt caatgatctc aaaacccttt 2370961 acctgaacct tcgcctgctc agtataacga aaatccgtaa taaacgctgc tttgtcaccc 2371021 gatataacag ccaaacccgc cgaacctgta aaccctgtca tatagcgtac attagtgttg 2371081 cttgtaatca gcatgccgtc aattcccagc tgtccaaaca ggtttcttaa tttctctagc 2371141 ttcatcttga ttctccccct tgctggctta ataagtagcg aacagcaagc ttgtagcctt 2371201 cagctccaag accgacaatc tgccctttcg caacaggagc gataaccgac tgatgcctga 2371261 attcttccct ggcgtataag tttgataaat gcacctctac cacaggaaga ctgatgcttg 2371321 aaacagcatc cctgatcgca tagctgtaat gactcagggc gccggggttc agaacaatcc 2371381 cgctgtattg ctcctcagcc tcatgtatcg catctatcaa atcaccttcg tgattagact 2371441 ggaagaaagt gagctggata tgtaaggctt cagcaaactg aaaaagatct gtttcaatat 2371501 cggtcagtgt ctggcggccg aatacttcag gctcacgact cccaagccgg ttaacattcg 2371561 gtccgttcaa aatcaaaaaa tgaggcacac aatctctcct tttcgcgagg gtttctcatg 2371621 taaaaaatgt tcacttctcg tgaacatttt atcatactgg aaaaggatta tacactattc 2371681 tctatgcatt cccagcgcac gtgcaagctt ttccgaattc agctcattgt attcaaatga 2371741 aatagaatac ccgacaaaca gcccgtaaag caaataaatg caaatggtcg taataattgt 2371801 atctgatgtc agttcggtca ccgtgcgcac atctggaaaa atcggattaa aaacaaaaaa 2371861 cacgagcagc caaagcacca agccgtataa aatacccggc cacattgttt ttaaacgttt 2371921 caatagaaga aaataaagaa atgctgcgcc aattgaaatt actccaatca aaatgatgct 2371981 gattaccgtt cccagcccat gttttttcca ctctccgagt acaaacggct gcaatatcat 2372041 attcgggctg atttcggaaa aatgaaacaa atatgcgata taagcaacga aactccaaag 2372101 tacgcctccg caaaaacctg ttgccgccac cctgccggcc attgaaacag gcggcttttg 2372161 cttctcattc aattcttcat tttgttctgt atctttttcg cttgtcatca tggcacctcc 2372221 agttaaagtg tgcccaaaaa atgaaatgtc aataaaaaag ctcacacttt ttggcagctg 2372281 cgagtaaaat ttgaaaataa cgggtataat gcatgtagaa aaagcaaggc tatggcaatt 2372341 ttttcagcct gtcaatctag aggtttagcg ctgtttcctg tacaatagag tgaaaggaaa 2372401 tggttagcaa tcctaaagaa ataggcaggt tgataatatg tcaaaacata aagttccgcc 2372461 cgcttacggc gggcaggctg ttgtggaagg cgttatgttt ggcggaaagc atcattacgt 2372521 tacagccatc agaagaacgg atggaagcat tgactttttt aagcttccac gcaaacacaa 2372581 cccgaaactg aacatcgtga aaaagatacc gtttttacgg gggatcgcgg ccattatcga 2372641 agcgagtgca aacggcacaa agcatttgaa tttttcaagc gaacgttacg ggctcgatcc 2372701 atctgaagac gagacacttg agcaggaaga aaaaaaatcc tctgggctgt ctatgtatct 2372761 cagcctcgca gttataggcg tcctatcatt tttgttcagt aaattcgtat ttacattggt 2372821 tccagttttc ttagcggaac tgacaaggcc gattttttcc ttgaacacag cgcaaatcgc 2372881 gattgaaagc ctgtttaagt tgattttgct gctcggttac atctattttt tgtccatgac 2372941 accgcttatt aaaagagtgt ttcaatatca tggagccgaa cataaagtca taaactgtta 2373001 tgaacagaat ttgccaatta ctgtggagaa tgtccaaaac caatctcggc ttcattaccg 2373061 ctgcggatca agctttattt tatttacgat tattgtcggc atgtttgttt atttactcgt 2373121 tccgacagat ccgctttggc tgcgtgttat agatcgtgtc gcactgatac cggtcgtgct 2373181 tggtatatcc tttgaagttc tgcagctgac aaacaaagtg cgtgacattc ccggtctgaa 2373241 attacttggg tacccgggac tttggcttca gctgttaacc acaaaggaac ctaaggatga 2373301 acaggttgaa gttgccatcg aaagctttaa cgaacttctc agactcgaag cattgtctga 2373361 gcaaaatcag aagccttctc acaacgtcat ctaaaatccg ttgccctgct attactttcg 2373421 gaggtggaca gttatgaatc atcgtgtaca acctattatt gctgtattaa ttgcgctggg 2373481 agcgttcggt ttcctctatg tgctggtaac caatcccgga gaaatggcaa aaatggcggt 2373541 aaccgtcatc gtggcaggta tcattattta ttttattgtg aaatatgtaa tgaatcgaaa 2373601 tgcgggcagc gaaggagcag ccttcaaaaa agcggcgaaa caatcacggc gccggatgaa 2373661 agaacaaaaa gcaaaacacc gcgccggaca taagggacgt gtcagccacc tgcgaagcgt 2373721 tccgagcgcc agcaagccta agccgatgat tctcaagaaa aaaagccaga ctcagctgac 2373781 tgttatagaa gggaaaaaaa ataaaaagaa aaacagagcg cttttttaat aggtccactg 2373841 ctttaaaaac agctctgtcc gtcttttacc tagctcaatc agggctagtt ttttttgttg 2373901 tgttaaatga aaatcagtgg ccattacgtc atcaacaggg agaaaaatga tattttgttc 2373961 atagcgtgac gcaatgtgcc ttgcgtcatg agcatccttc atcgtttcaa acagggcgcc 2374021 gaacagttca aaagcgttgc ggatattttt tttcggacgc tctctttcac gcggcgcaag 2374081 cgtgacaccg atcacagggc gctttctttc ctttgaaaac agccagattg gaaaattgct 2374141 taacacgcct ccgtcgacaa ccgtggcggt gcctgtgtcc gtttttaatt ttatcggttc 2374201 aaagaaatac ggaatgctgc agctcattct gaccgctctg gcaaccggga acatatctgg 2374261 atttaacccg taacgggcca aatcgtccgg caaaacaatc atggtgccgt ttgtcagatc 2374321 agaagcaata aggcgcagag accctttctg caaatcgccg aaaaccctta tgcctttcgc 2374381 tcttaacaga tcagcaatcc atttttctat cgtatcgcct ttgtataagc caagacgcca 2374441 gtagatggac acccactgga gcatctttaa ggggagaaat gagtacctct gatccagcaa 2374501 tttctctccg tccacttctt caattaaagc gtggatttcc ttactggtgt aacctgacgc 2374561 aatgaaagcg gcaataatgg cgccggcgct tgtacccgca actcttttaa agcggaagcc 2374621 tttttcctca agcacttcat aagcgcctgc gagcgcaatg ccttttactc ctccgccgga 2374681 aaacacaccg tcaatataca tctcattccc tccccctcca tccgatcgtt tattaccatt 2374741 ttaagaaaac acgcgaagaa atagaccaac gaatgacggg tggcgtcagc gtatcaaaaa 2374801 agacggcctc cttcgagacc gcctttttac tgattatgat gttctgtttt cttttggatt 2374861 gatttcagat cttttttacg ggcatcatct tcttcaaaat attgaacaag atccccgatg 2374921 cgatcaatac tgttccagct taaatgatgt tcgattcctt cgacatcgtt atatattttc 2374981 tcttcatcaa caccaatgat tcttaaaaac tgctcaagca attcatgtct gtataccagc 2375041 cgtttgccta tttttttccc tttagacgtt aacacgagac cgcgatattt ttcataaatt 2375101 aaatattcgt ctttatctag tttttgaacc atttttgtta cagaggaggg atggactgcc 2375161 aatgcttccg cgatatcgga aactcgtgca tatccttttt cttcaatcag catataaatc 2375221 tgttcaatat aatcttccat acttggtgtt gtcatcgaaa ccctcccaaa aagcacctta 2375281 actttataaa ccattacaag tttacactaa tgaacttgaa aaaacaagga tgctccgcgg 2375341 gtcaaaagcc ctgtttaccg cttataattc cattcatctg aagcgtactt tgtttcagcc 2375401 aagtgatgaa caaaatcaag ctcttcctga gaaagttcat atggctccaa atgaatgtta 2375461 agacctgttt caaatccttc tttaaaggct ttacgagcct catccatcgt cacccgcttt 2375521 tcgatgagtt cattaatggc aaccgcttta tttttgaaat tgcgctgcat ccgctctctt 2375581 actctttcac ttggatataa gaacagatcg aacagcttgt cctcatctaa atcaagaaga 2375641 atggagccat gctgaagaat cacacctttt tgtctcgttt gcgcgcttcc cgccaccttg 2375701 cgcccctcaa ccactagttc ataccacgaa ggcgcgtcaa aacaaacaga tgaccgcgga 2375761 ttttttaagc tttctttttc tttttcagtt ctcgggatgg caaagtaagc gtccagaccg 2375821 agatttctaa agccttgaag tatgccttct gaaataaccc ggtaagcctc agtaacagtc 2375881 gccggcatct cggggtgctc ttccgaaaca attacgctgt atgtcagttc ctgatcgtgc 2375941 agcacacctc tcccgccggt cgggcgtctg acgaatccga gattatattt atgtactgct 2376001 tcaaaattga tttccttttt aatattttga aaatacccta cagaaagtgt cgccggattc 2376061 cagccgtaaa aacggataac cggggggatt ttcttttcgc tgtgccaata taaaagcgct 2376121 tcatcaagcg ccatattgaa tgcaggactt gcattgcctg agtctataaa ccgccaagtt 2376181 tctttttgca ttttaagacc ttccttaccg ttttaataga atcagtttat caaactgtcg 2376241 ggaaaatgaa aaatatttta gttccattat agatgacaat cacgctgtgc tttactataa 2376301 tagtatttgt cgaaaacggc tctatgacct tgttttatga agcagggttt tgattttata 2376361 tgctaaagga gtagaatcac attgtctaat atgatcgttt tgattatttt tgctgcattt 2376421 atcatctata tgattgcttc atatgtctat cagcagcgaa ttatgaaaac acttaccgaa 2376481 gaagaattcc gcgcgggtta ccgcaaagcg cagcttattg atgttcgtga gccaaatgag 2376541 tttgagggcg gacatatttt aggcgcccgc aacatcccgc tttcccagct gaaacagaga 2376601 aaaaatgaga tccgtacgga caagcctgtt tacctgtact gccaaaacag tgtccgcagc 2376661 ggacgcgcgg cacaaaccct gcgcaaaaac ggctgcactg agatttacaa cctaaaaggc 2376721 ggctttaaaa aatggggcgg aaagattaaa gcgaagaaat aaagcaaaca gctgtctggt 2376781 agacagctgt ttttatttat ctttcttccg cctcgtatct gagcactggg tgtctcgccg 2376841 cttttgtttc atccattctt tttacaatcg ttgtatgcgg ggcctcctga acaagctccg 2376901 gattctcctc cgcttctttt gcgatttgaa tcatagcatc aataaacgcg tccagtgttt 2376961 cctttgattc ggtctctgtc ggctcgatca tgatgcattc ttcaacatta agcgggaaat 2377021 aaatcgtcgg cggatgatag ccgaaatcaa ggagccgttt tgcaatatca agcgtacgca 2377081 ctcccagctt tttctgccgc ttccctgata atacaaattc atgcttgcaa tggcggtcaa 2377141 acggaagatc gtaataaggc gcgagttttc tcatcatata attggcgttt aacactgcgt 2377201 tctcagtaac agcctttaat ccgtcaggcc ccatggagcg aatatacgta tacgctctca 2377261 cattaatgcc aaagttgccg taatacggct tcacacggcc gatcgcatga gggcggtcat 2377321 aatcaaacgt aaagcgccct tcttttttga ctaaaactgg ctttggcaaa taaggaatca 2377381 gatcttgttt tacgccgaca gggcctgagc cggggcctcc gccgccatga gggcctgtga 2377441 atgttttatg caggttgagg tgcaccacgt caaatcccat atcaccaggt ctcgccttgc 2377501 ttaaaacggc atttaaatta gcgccgtcat aatacagttt cccccccgct tggtgtacaa 2377561 tttccgccat ctctgtaatc tgctcctcaa acaagccgag cgtgttcgga ttcgtcagca 2377621 taagagctgc agtttcttca ttcactgctc tttttaaatc ctctaaatca acaagccctt 2377681 tttcattcga tttcaccgta acggtttcaa agcctgctac tgttgctgat gcaggattcg 2377741 tcccatgcgc ggaatcaggg acaatgacct tcgtccgctt gaaatccccg cgagcttcat 2377801 gataggcacg gatcatcatc agccccgtcc attcgccgtg cgctccggca gcaggctgaa 2377861 gcgtaacctc atccattccc gttatttctt caaggtgttt gcttaaatca tataaaagct 2377921 ctaatgcgcc ttgcaccgtg tcttcatcct gaagaggatg aatcgcagca aaaccaggaa 2377981 tacgtgcgat tttttcattg attttcggat tatatttcat cgtgcaagaa ccgagaggat 2378041 aaaaaccgga atccaccccg tgattgcgtt tggacagcgc tgtataatgg cgcatgatgt 2378101 ccagctctga aacctccggc agcgctgcgt cttcgtcacg aatataggtg tctgacaaga 2378161 ggtcccccaa ttcgatttcc ggtacatcga gctccggcag actatagccg attcggcctt 2378221 ctcttgaaag ttcaaaaata agtgcctggt cctgattact catggcgatc ccccaattcc 2378281 tgaatgagtg cgtcaatttc ttcttttgtt ctcagctctg ttacagcaat cagcatatgg 2378341 cagtccagct ctggatacgt caacccaaga tcatatccgc caatcatgcc ttttgccagc 2378401 aaacgcttgt tcacagctct caccggctca tccagtttga tgacaaattc attaaacatc 2378461 ggcccgtcaa acataacagt aaggcctgct ttttttgctt cttgctttgc atagttggct 2378521 tttaagagat tttggcgggc tatatctttt acgccgtttt ttccgagagc agtcatggcc 2378581 actgatgctg ccagcgcatt taaagcttgg ttcgagcata tatttgatgt tgctttatcc 2378641 cggcggatat gctgctccct ggcttgcagg gtaagcacaa agcctctttt tccgttttcg 2378701 tcttccgttt gtccgacgag acggcccggc acctttctca ttaatttttt agtaacggca 2378761 aaaaagccgc aatgcgggcc gccgtatgct gaaggaatgc cgaaaggctg cgcatcaccg 2378821 acgacgatat cagactgaaa cttgcccggc ggagtgagaa gacctagcgc cagcgggttg 2378881 gctgaaacaa taaacatgga tttcccttga tgagcgatag gctcaatatc ctttagcggc 2378941 tcgatcctgc cgaaaaaatt cgggtactga acgatcactg cggctgtgtt ctcgcaaacg 2379001 gtttggcgca atgcatcaag atccgtaacg ccatccgcag cgggtacttc aacaacatca 2379061 atatactgac cttttgcgta agttttcagc acctctcgcg attcaggatg cacggttttt 2379121 gacacaacaa tttttttctt tttcgtgtgg cctgaagcaa gcattgctgc ttctgccaag 2379181 gctgttccgc cgtcatacat cgaggagttg gcgatatcca tgcctgtcag ttcacagatc 2379241 atcgtttgga attcaaaaat agcctggagc tctccttgtg aaatctctgg ctgataaggc 2379301 gtatatgcgg tataaaactc agagcgcgaa atgacatgat ccacaatgac aggctgatag 2379361 tggtcatata cacccgctcc taagaaagaa gcgtattgta cggtatcacg atttttagag 2379421 gccagctttg tcagttctct tgttaattct gtctctgatt tcgctttttt gatttgatgc 2379481 tcttttttat atttgacgtt ttccggtata tcagcaaata aatcatcgat gctgcttacg 2379541 ccgatagtag caagcatctc ctgtttatcc ttttctgttg cgggcaaata acggtgcttc 2379601 atgtgttgtc tcctctctcc aagaaaaaat attagcgttt ataaaatggt gttttgacaa 2379661 cctttgcttt cactaatttt ttgcgtatct ctacatctac aacagtcccg atctcactcg 2379721 tttccgaatc aattaaggca aggccgacgt tttttcctaa tgtcggtgac tgcgtgccgg 2379781 ttgtcacctt tccgacagac ttgccatttt ggaaaacctc atatccgtgc cgcggtatcc 2379841 ctttttcaat catttcgaga ccgacaagtt tgcgcttcgc tccgttttct ttttgttcac 2379901 tcaatactga cttaccgaaa aagtcagact cctttttgtg ctttacagca aagcctatac 2379961 ctgcttcaat cggtgtaata tcccgggtca gctcctgacc gtagagcggg agcttcgctt 2380021 caaaccggag tgtatcacgt gcaccgagac cgcatggaat caatccgtat gcatcccctg 2380081 catcgatgat ttttttccaa atatgcatag catcatcact gcggcagtaa atttcatacc 2380141 cgtcttctcc cgtatagcca gtgcgtgaaa taagtgcttt gcggccgctg atatcggctt 2380201 catcaataaa cgcaaacggc tttaatgcag acacatccgc atctgtcaga ttttttaaga 2380261 tcgcttctgc tttcggtccc tgtacagcca agagcgcgat ttgatctgac tgattgtcaa 2380321 tctgcacatc acctgctgca tgttctttca tccaagccaa gtctttatct atattagaag 2380381 cattaatgac aagcagatag cggttctctc ctttttgata gataagcaaa tcatcgacgg 2380441 ttccgccatc cgggtaacac atcgctgtat attgagcacg gcctggcgtt aacgcggaaa 2380501 catcatttgt catcaatctt tgcaaaaaag acagactgtc gttccctgac acttcgactt 2380561 ctcccatatg agatacatca aacaaaccgg ctgcagttcg gacagcctcg tgttcttttt 2380621 ttatagaaga aaattgaaca ggaagctccc agcctccgaa atcaatcgtt tttcctccat 2380681 attccttata caggtcaaat aacggcgttc ttttcagcat ctaattcctc ccctttatca 2380741 acggcgcagc taaaaaacat acaaaaaagg acagagaaac acctcatgta aaatgaaggt 2380801 tctctgtcct ggcacctgaa agtttacttt gcatacgcaa agacgtcccc tttggtggtt 2380861 tgcgcatccg cacaaacact ctccagagtt gcgtcgagca agagttcttt tgcctgagag 2380921 attcactccg cagtttgctc cttcggcgcc tgtatcccga ggttttcggt caggtctctc 2380981 cccttgctgt cattcgctca tattttcatg ctgttatgga catactatag caatatctta 2381041 catcaaatac atactcatat cctaccatca tcactatatg ctgggcaaca gcaatttggg 2381101 cagatttttc ttatattatt catcttaaga atcgaagaat aagaaaggcg gtttcaaagc 2381161 aatgaataca gaaatgatct acgatgcaaa atggcctgaa gaatttgctg aaagactgaa 2381221 aaacgatggc ccttgggcaa actgggaact gtacaagctc tctgcagaaa tccagaaaac 2381281 attagcaatt ccagagtttg aaggcttacg ggctccttta tatctgcctt cctttacgcc 2381341 gctcccccac cagcttgaag tggcgcaaaa agtggttgaa aaaatgaacg ggaaagcgat 2381401 tttagcagat gaggttggtc tcggaaaaac ggttgaagct ggactgattc taaaagaata 2381461 tatgattcgc gggttagcaa aaaaaatttt gatccttgtg cccgcttccc ttgtgtcaca 2381521 gtgggtcaaa gagcttcagg aaaaattttt gattccggct gttgaacaaa agaaaagcta 2381581 tgtgtgggag caatgcgata ttgtcgtctc atcaatagac accgcgaagc gctcgcccca 2381641 tcgagaaatc gttctgtcta tcccatatga tcttgtcatt attgatgagg cacacaaact 2381701 gaaaaatagc aaaacgaaga actatgaatt tgtccggaat ctcgtaaaaa aatattgcct 2381761 gcttcttacc gcgacgccaa tccagaaccg tatcgaagag attttcaatt tggtgtcctt 2381821 attaaaaccc ggccatttag gcagtcagaa tcactttcag gaggagttcg ccaagaagaa 2381881 atccagttta gaagcgcatg aacatttaaa agatcttgtg aataaagtca tgatccgtaa 2381941 caggcggcat gatacagggc tgaattggaa acagcgccat gttgaaacag tgccgattca 2382001 attttctcca tcagagcagg cgctttatga tgaaatttct cgtttgaagg acagtatcaa 2382061 taaaccagcc agcatgttct cgattatgac cttgcaaaga gaatgctgtt cgagcagaga 2382121 agcggtatat atgacgctga aaaagatgct tgatcaaaaa gagaaacaag cacctgccat 2382181 tgatgaggat acgatttcag ttttgataga tcgcatcaat caagtgacac aaaactctaa 2382241 agcgcttcaa gttgttgact tgatcaaaaa gatcgacgat aaggtcatca tttttacaga 2382301 ataccgcgca acccagattt atctgcagtg gtttcttcag caaaacggca tcagttctgt 2382361 gccgtttaga ggcggattta aacgtggaaa aaaagactgg atgaaggatc ttttccgcgg 2382421 aaaaatccaa gtccttattg caactgaagc aggcggtgag ggaattaacc tgcaattttg 2382481 caatcacatg atcaactatg acctgccatg gaacccgatg cggcttgagc aaagaatcgg 2382541 aagaattcac agactcgggc aggagcgtga cgtgcatatt tataacatgg cgacaaaaca 2382601 tacggtggaa gagcatattc taaagctttt atatgaaaaa attcatttgt ttgaaaaagt 2382661 ggtcggtgaa cttgatgata ttttaacgaa aattcaagtg aacaattttg aagagcacct 2382721 tcatgacatt ttgtatcact cagcaacaga agaagaaatg aaaataaaaa tggataactt 2382781 aacctcattt ttgtcttata aaaaacagct gcctgctgaa aaaagaggat cttagcctgt 2382841 aaggaggttt tattagtgag acagcaagag gttcacgatt ttctgctgcg tttttttcaa 2382901 gcaaacagct gccaaatcgt cgatcaaggc ttaggctata tgacagtgca gcttacagtt 2382961 gaaatggaca aacaaatcat gaaccgccct ttctactggc attggcgcga gaagacaggc 2383021 ggtgatccga atccaatgaa aatcactttt attacagata aagaaaatgc gccaaaagac 2383081 ctagatggtg aatttatata ttttggggcc ccgcgtcttt ttcaaatatt caaagctgtt 2383141 aaacaaaatg ggagatttac cagaatgtat gagaaaattg aatcagccgg agctaaagtc 2383201 ccacttcagc cttggcttgg tataaatgtc acgatttcat accagtccga catgaaaaag 2383261 gataagttat tgtcactagg tcttcaccta gtctctggaa cgataattga agattttcaa 2383321 agcaagctga cccagttttc actgacgtct caaatatgtg actattgctt caccatttca 2383381 cctatgatca aaccagaaag cggacttaag cgtatggaaa actatatttc caaatccgct 2383441 atgcaggagc cgtccgactg ggcggaacag gcggttaaca ggtggaagaa tgatatgaca 2383501 ttgcttgata agttttacga gcatatagaa gaaaaaccag aagaatacca tctagaaaaa 2383561 caggcgctga aaaccttgta tcaaccaaag atatcagttg aaattgaaaa tggcggattg 2383621 ttttatctgc aaaataatat ttcaagctaa cttttttacc attcgacatc attctcgttt 2383681 tttttgagaa aatacgatta taataaaggt atattggaaa aaaattctgg tgatttaatg 2383741 gcaaatgact tccagagact aatgaagcat acaataagtc atggccggac tggctgaaat 2383801 acataaacaa gtattttagg aggagaaact gcatgaagaa tgcaaaacaa gagcactttg 2383861 aattggatca agaatgggtt gaattaatgg tggaagccaa agaggcaaat atcagcccgg 2383921 aagaaatacg aaaatattta cttttaaaca aaaagtctgc tcatcctggt ccggcagcca 2383981 gaagtcatac cgtaaatcct ttctgaatgt gctataatat cacaaggaag gtgatgacat 2384041 tgattggcca gcgtattaaa caataccgta aagaaaaagg ctactcacta tcagaactag 2384101 ctgaaaaagc tggggtagcg aagtcttatt taagctcaat agaacgaaat ctacaaacga 2384161 acccctccat tcaatttctc gaaaaagtct ccgctgttct ggacgtctcg gttcatactt 2384221 tgctcgatga gaaacatgaa accgaatacg atggtcaatt agatagtgaa tgggagaaat 2384281 tggttcgcga tgcgatgaca tccggggtat cgaaaaaaca atttcgtgaa tttttagatt 2384341 atcaaaaatg gagaaaatcc caaaaagagg agtagtgcct gagcagaggc actaactcct 2384401 cttttgtcaa taaccatcga gacggcccag tatatgaata ctgggccgtc tctttttttt 2384461 gctgttatta atttttatcc tcgctatgcg ctttttcatt ttctttcacg taaccatctt 2384521 tatcagtatg gtcctttttg attgtcaagc cgttccactg tgtagcttcg aatgagaatt 2384581 gaagcttaat ggagttgcct tgatatttat tttgaaccat aagccctttt tcatcttttg 2384641 ttttatcatc cttgaattgg atttccattt gaacctgatc gaagtcagtt ggtgtttttg 2384701 gaacaccatc atattcagga gcggttttac catcaattgt tgctacattg actttaccgc 2384761 ttgcatttaa gaatttaggg tcaatttgtt ttttgatttt ttcagcagcc gctgcatcat 2384821 ttttagcaga catcaaatac aagtctttaa ggttcgcatc atctaaaata atgtttttcg 2384881 ggtagccatt gccgccctct tttccaactg tcaacaatgt cacttcaaac tggctgagga 2384941 aatcttctgg agatgtattg ctgccgccgt ttgctttaaa atctccataa ttaagcgcca 2385001 ttagaacttc tttgatcgca agtgatccgt tattttcaaa ttggaaatcc tttgtcaact 2385061 tatctcccgg ctttagattt gataagttca cactcgctga attctcttta gcagataaat 2385121 caagcgtacc tgatgcaaaa gtagcatcct ttgatttaat gtcgttaaat gctgcccatg 2385181 ttcctcctcc aactaaagct aatcctagtg ctgcagaagc aactcctaaa ctcaatttct 2385241 ttttcatacc catggtaagc tcccctttta ttgaatgatt ttatatcgaa acctgttgcc 2385301 aggtttacaa ctgaagttaa gtagacatgg tgctgtcctt tgtatctgtt tccaaggctt 2385361 ttgtctttct ttcaatttct ctaatggcgc tgctgatcgt cacaaaagcg taaactaaca 2385421 gcatcacgcc gggaacaatc aataatacag ccgttccaat cggctggctg gcaaaatgaa 2385481 gcatatagcc ggcatatgga agctgaaaac ctgtgtattg cgcgcgaaca ttttcgtccg 2385541 atacaggcgc tgaatcagct gctgcattat tatcaccttt tgttttaaat aacaaatggt 2385601 ctccttgctt tgttatgtca acaattctgt gggtgaccgc cgtatttgca tcctgcataa 2385661 atgtaataac gtcacctttt tggagctctt tcacatcagt gatttctttg accaatatta 2385721 aggaacctgt attgaactcc ggctccatcg aacctgacag aactgatttc agcgtatacc 2385781 caaacactgc cggctctccc ccggatgaac gtgttgaaat cacgacaagt gtcagcacaa 2385841 taataagagt aaagatgatc acgtataaaa tattactgat cagcttcatt gcttttttca 2385901 tcctcttccc cgctttcctt ctggtctgat tgagtttctt tttctttggt tacagcttct 2385961 tgagatgttt cttctttcat tgttttttcc ggtatatctt tttgtgttgt ttcattctcc 2386021 tttttgacgt ccgactttgt ttctttttta gggactgtcg gtttttcatc gcattttgca 2386081 agcctcatag gctccgacca ctcaaatgta ctgccgtttg ccgggtagcc tgccggttta 2386141 tatactttaa atgcataaat gccgggtttc atttttttct tggtctcaat tttataaagt 2386201 gaatcgccga tttgattgga gacaaatcct ttttcgatca cgttcccatc ctttaacggt 2386261 ttgcgggcat tttcaagctt atgaagctcc cacttccact ttgatttctt aagtttctca 2386321 cctgtatttt cgagcacagc aaataaggcg aaaggtgagc atacagtgcc tttcgtatcc 2386381 gtttgatctg atatgtgcaa atcactttga tcccagcgtt tatcataatg gcagttttta 2386441 tctgtatgct gaaagtcttt acacgtttga agtgagacat caaatgtttc aatatcatga 2386501 aaagcagcgc ttgtatcatc ggaaaattgt aagcatattg cggcagtcag actgaaaatg 2386561 actgaaagct gaaagataag cagaactttc agtttcgtct tcgccttttg ctgattgtga 2386621 aacaatcgaa acatatctta cctcctgtaa aacactgtaa cttgatatga caatcgttct 2386681 ctttaaagaa cttcacaaat agagtataat caacgattta tagatttaaa aacaccgaaa 2386741 tcgctcattt tgttcgttta aaagaatgtt ttcatcatat tacaaagtct tgctcagtat 2386801 tgctcatttt ttcaattttt tagaaatttt tgggattgtt atgtgagaat ttaaatgcat 2386861 atcccattat tatttggtaa taataaacaa agaaagggtg acagcatgat gatcaaacaa 2386921 tgtgtgattt gtctatctct tctcgtcttt ggcaccacag ccgctcacgc agaagaaaca 2386981 ccgcttgtaa ccgcccgcca catgtccaaa tgggaagaga ttgctgtaaa agaagcaaaa 2387041 aaaaggtacc cgctcgcaca ggtactgttc aaacaaaaag tatgggaccg taaaagaaaa 2387101 gatgaagcag tgaagcaata ccatttaact ctgagggaag ggtcaaaaga attcggcgtt 2387161 tttgtgacga tttcatttga tccttatagc caaaaggtca ataaaattgc catattagaa 2387221 gaatatcaat aaggtcctcc attttttgaa ggaccttatt cgtttatttg cggttatttt 2387281 ttccgtttca gccaaagtcg gaagccatag ggtaaaatac cgaaccactg ctgggaaaca 2387341 ggcgtttttg tttctttccg cacctctttt cgttcttttc gctcatctct cggagtatct 2387401 atatatttga caaattgctg cgtcatatat ttaacataat cattcgtttt cacgtgatca 2387461 cctcatcatt caattattat gagtgttgtc tcacatgact ttttttatac cctttacact 2387521 gttttattct gtccatctca gcagtttttt ctgtttttgg tcaaacacga tctgtgcagt 2387581 tctttctgtt cccgaatccg ttgacactct taagttgatt tctttttgtt cttttatcga 2387641 tgtatcatga atgtaataag aaacccgtcc atatagaaat tgctgcgtac cctcctggcc 2387701 tttccgttcc tctagaacat gccgaatcga aagaagcacc ccattttgaa gcaaattctc 2387761 tcctatgtat aactcttttg tttccttctc aaacatgcag cgtgaaatat attgagcagc 2387821 aacaaagttc acgattaaca gcacaagcgc tgacacaaaa agaacagctg gataaataaa 2387881 ccctcttgta cgatacattc acccccctcc taaatacgaa tagactggaa aagcagtttg 2387941 atacactttt tggtcttcac tctcaatttt cagcaaaaca acaccatttt caatatcagc 2388001 tttcatggca gtaatatgat ctaaaatcgg aacatgccct ttgccatcca ctctttttct 2388061 tatcattgaa tgataaatgt caaaacggat gtcttgtccg gaaagattgg tgcagattaa 2388121 cacgctccca tgctcggctg tcttaactgc ctgtgattcc ttgcattcat tcatcatctg 2388181 ttctatcgaa atcatccatt cctgctgtgt gaaaccgtca tgttcctgct gtcgagacaa 2388241 aaacagatgg ataatcgcag ctaacgatcc tgatatgagc aaaaagactg agagcgaaaa 2388301 taatacgtta agaagcgtgt agccattctg tctgcaaaat gctgaggcaa aatgattttt 2388361 ctttataagc tgcggctttg atacatacgt tttgatattc gccctcctcc tcccacttca 2388421 ttgcatagat atgattgttc tttgtaatcg tttttgacgc ggctccttca ccactcatga 2388481 catatttgct aatgctctca ttcatcatct gatagccaat ttctcgtgat tccgccattt 2388541 tttcatcagc catcagcttg tcccacaagg ggacgactgt cagcagcaca aacagccaca 2388601 ggcttagcgc agacattgtt tctattgtag aaaaaccttt attttctctc cacattgact 2388661 ctcccgctcc ctagataaac tgttatgtca taaacggcat ggccttttac tcgtattttt 2388721 ccgcctgcat tcgggtgccc tttctcatta aattccaaac ggtcttttaa tgtcagcagt 2388781 tctatagaaa gtcccgttgc atacggacgt tcaataaccg tatcaccaat gactaattga 2388841 tattcttttt tatgaaagag aatttttgtt ctttgttgac gggaaatagc agtctgctgt 2388901 gtgagcataa tatcattttt cagctgactt gctgcctgtc ggacagctgt attgtcataa 2388961 gcaggaggaa gtgtagtgaa gacggccacc aggaggatag aggcaaggct taacacaagc 2389021 aaactttcta aaagggtaaa ccccttctcc tcgtttaatt taatgttcaa ccttaacttc 2389081 tccgccggtg atgataatgc gcttaccatt tggacagaca gcatcctttt tcacatagcc 2389141 ctctgactgt aaatcggcaa ggctcggagt ttgtccttca tgatcaagct caaatgcagt 2389201 catttgtgcc ttaaccatgt tttgtaagcc ttcacagccc tttttttgaa tggtttgatt 2389261 atgtttcgtg acgttcggta tcgtaattaa aagcaaaatc gaaataataa agagcacgat 2389321 taacatttca acaagtgtaa atcctttctc attcatcagc ctcttccttt cacatttgat 2389381 tcatcatctg atacataggc acaagcatag ataaatacac aagtaagatc atcgctgcaa 2389441 caaatccata aatcattggc tgaaggatgc ctgtccattt ttgcgctttg tgttccagcc 2389501 gctgtaatat gaattggctg tatgtgaaaa gctcccgatc caatcggccg ctcagctggc 2389561 cgtgagatat gacttttgat aaatcagttt cataaaaaag gcttccacaa atagcggatt 2389621 caattgactc accggctttt agccgttcaa tcaattgttc agcctcgcag cggtagaaag 2389681 ggagaaacgt ttgatgttta aatgcattaa ggctgtcata aattgagagg cctgatttta 2389741 aaaggctgct tagctgcaaa gaaaaaaagt agctgttaaa cagctttaca agctttccaa 2389801 ccaaaggaat cctgatacaa atcagcattt gccgggcagg tgattttttc ttaaacacaa 2389861 gccaataata aatcccgata cctgctgtaa aaagaacaag caaaatgatc acaagatcaa 2389921 tatgctgaaa aaaagcaaaa agcatatcgg ttgaacgtga ggtttccata ttcatcgatt 2389981 gatagatacc ggaaaactga ggaatgatga tggactgtaa catataaaac atgacagcga 2390041 ccgtaaagat gaggaaaagc ggatagcgca gcactctttt cagctggtct gcctgtgcaa 2390101 tttttcgttc cagcagctct ccgctctgga tcattgaagc aggcagttca ccatgtgttt 2390161 cagcaaaata acaaatacct acggcttcct tatgaaatga caaactcttt agtacttgat 2390221 aaaacggagc cccttccctc aaacaagtga ccgaatcagt caagtcagcc gcctgcctct 2390281 tattcatctg aagttccatc aggcgtaatc catccagaag tgtatatccg cccgcagtca 2390341 tttcaccgag cctctttaat aacctggctt gatcctttaa caaccagact tttctaatct 2390401 ttttcatgat aaacccaccg gtcatagttg tttgtcgtta aatagccgag cgcaattcct 2390461 tttctgataa tttgacgaag cgtttgatat tggtaatttg catgatttcc ttttgcctcc 2390521 tggatacatt gctgaagatt tttcccgtat agaagctcat aaacgctagc tctcctagta 2390581 tttcgtgact gtcggcaata cactgatgaa catccgtttt cacaaaacgg gcaagccaaa 2390641 tcaaccaagc gctgagccgc tattgcaatg acagtctgtt cgatttcatt catattgata 2390701 ccgaattcaa gcagtctgta aattgcgccc tttgcgtctc tcgtatgaag gctcgttagt 2390761 accagatgtc ccgtcatcgc tgcccgcacc gcaatttcag ctgtttccgc gtctctgatc 2390821 tcacctaaaa taatcatatc ggggtcatgg cgcaaaattg ctttcagacc tgcggaataa 2390881 gttacaccgg ctttttcatt cacctgaacc tgaagaacat cttcgtccct tgtttcaaca 2390941 gggtcctcta atgtgacaat atttcgatta aagtgttttt ttgcatattg aacgagagag 2391001 tataatgtgg tagtcttccc tgaaccagtc ggcccggtaa aaatgagcat gccatgggaa 2391061 tgttttaaaa acgagagtaa tgtggctcct gtcttcggaa atagcgacaa tttatcaatc 2391121 gaagggatat tgtattgggg catcactctg atcacgaggc tttcttcatt aattgtgggc 2391181 agcgttgaca ttcttaaatg aacatttccc tctttcaact ttaacgtaag cgaaccgttt 2391241 tgcggctttc gcctttcacc tatatccatt gctgaaagaa atttaaaatg tgaaatcagt 2391301 cttacgcact cttctttttt catgtccctt tttttcagca aggcatgatc gacccgaaaa 2391361 tgaatgatag cgtcccgctc cctcggcaca atgtgaatat cagaagcctt tgttagatat 2391421 gcctcttcaa tcaagttttt gcttaccttt tctattgaat ccaatttgat tccctctcct 2391481 ttcaacgcat attgtagaaa aagaagaaaa ggtaatcaaa cagggaaaac gtgattttgt 2391541 gagatgttat atgctgaaaa accaattctt tctggcaaga aaaaagactt tcaactgaat 2391601 gtacccctgt cattataatt ttccctataa ataaaaaagc agacatggtc accatgcctg 2391661 ctagattcca ttttcattat gctgttttcg cttattgacc agtatctttc tcaacggaaa 2391721 gatcgcctaa tgcaacaata ccggtcattt ggtcattttc aagaatcgat aaactgcgga 2391781 tttaatgctc tgtcataagc cccttgacat cgtatccggt caccctgata tgtctggtga 2391841 aaaagcgggg cacgctgcac aaaatatgaa acatcctata gagtccgcct ttttcgaggt 2391901 ttctttttct tcttccgctc ctgcagcata tctcccgtcc agcctttttt tctcaaatag 2391961 agatagatca gaactgtaga tgtgacaatc aataagaggg aaaagagata tccgtatttc 2392021 caattcagtt ccggcatcac tgaaaagttc atcccccata aggcacccag agctgtaatc 2392081 ggagtaaaaa gcgtcgtgaa aatggtcagc gcttttacaa tttcattccc cctatgtgag 2392141 gtaatgactt cctctgaatg cagcagattg ttaagctccc cttcaaattc gctgatgtat 2392201 gtaaatcccc tgtcaatctt cagttgtgtc cgctgataat cctttttccc ttcattttga 2392261 ggtaaaaagg tttctttcaa cgccatttca atttttttag cgcttaatat caaatttttc 2392321 caaatcatca gttcatggcg caggagatgg acgcggttta aaatgctttt gctattgtcg 2392381 tctttaattt gccatctgag ctttctcagc ttgacttcaa attcatcaac accgattaaa 2392441 tacgcattca ttagttcgcc gagaagaatt aaaaacccct ctatcgcatt gtccgctctt 2392501 tccatttgcc gaacaacttc tttgccttta atctctctca aaattgaaaa gtcaaagttg 2392561 attgtaaaaa aatattgtct ggtgatataa aagtgaaaaa cagtatggtc tttttcttca 2392621 ccaagcccct gatcataaac aatcgaccca aatactgctt cattttccgt ttcagttgta 2392681 tctactcgca aaaaattaac gtgatggtta ttttcaaacc acttttcaca ctgaggccag 2392741 tgagaaaaat ggattagatc tcttgcctta cttctttctt gaggccccat ttggtaccaa 2392801 aaccaatcct ttcccgtatg tgccttcatg tcaagctcct ccaaactttt gttctttatt 2392861 ctttaattgc ccaataaccg cgtcactaaa ccagtctgcc gcttcaacac atgttttatg 2392921 agcattttca ggtggtatgg aatgtagaaa gacatcggaa aagggaggtg catgccttcc 2392981 ttggagaagg cagttgtttt ggaatttatc aatttactag cagtcgctat tctcattttg 2393041 ttaacaggat ttttcgttgc cgtagaattt tcaatcgtaa aagtgcggcg atccaaaatt 2393101 gatcagcttg tcgcaaaagg aaagaaaggt gctaaagcgg caaagcatgt catcactcac 2393161 cttgatgaat atttatcagc ctgtcagctg ggcatcacag tcgcagcttt aggactggga 2393221 tggcttgggg aaccgactgt gcaaactctg cttcgaccgc tttttcataa agcaggctta 2393281 aatgaatcgc ttacccacct gctttcactc gtcatcgcat ttttagtggt tacgtattta 2393341 aatgtcgtta ttggggagct ggcgccaaag agtttcgcca ttcaaaaagc agaaagcatt 2393401 accttgttgt tcgctaaacc gcttatttgg ttttataaga tcatgtttcc attcatttgg 2393461 ctgttgaacc actctgcccg attgattaca ggagtgtttg ggctgaagcc ggcatcagag 2393521 catgagctgg cttatacaga ggaagaactt cgggtcctat tggctgaaag ctataaaagc 2393581 ggcgagatca gaaaaagtga attaaagtac atgaataata tcttcacctt tgataaacga 2393641 atggcaaagg aaattatggt gccgcgaaat gaaatggtta gtttgtcact agatgaagac 2393701 tccatttcaa atcttcagga aacagtcaag caaacaaaat atacacggta cccggttgta 2393761 agagaggata aagataacgt cattggcgtg attaatatga aagaagtgct gttttccatg 2393821 ctgacgaaag atttttcaat caagaagcat caaattgaac ctttcgtaca gcccgttatc 2393881 catgtaattg agacgattcc tatttataaa ctattgctga aaatgcaaaa ggaacgcact 2393941 catatggcga tcctcataga tgaatatggc gggacgtccg gtttggtcac tgtcgaggat 2394001 attatcgaag aaattgtagg agaaatccgt gatgaatttg atgcggatga agtgcctcat 2394061 atccgcgaac ttggaaagga tcattacttg ttaaatgcaa aattattaat cagcgatgtt 2394121 aacagcctgc ttggaaccga tttatcagag gctgaagtag acaccttggg cggctggttt 2394181 ttgacacaaa acatagacgc tgagcctgaa agtgccatag aatatgatgg ctactctttt 2394241 aaggtaaaag acatcaacag ccatcacatt ttatttatag aagttaaaaa agctgaatag 2394301 cccgtgaaag gctgttcagc tgctatcttt caagataaac atggcaaagg catcaacact 2394361 cttttatttt aaacccttta ttggccaggg ctttagcaag actttgctct gttttcacat 2394421 tcgaaaaatc cagacccagc ttcacgacag tttgggcaat ttccggcctg attcctgaaa 2394481 taatagtctc aatgccgagc aatttggtgc tgtcaatcac tttaaaaatt tgataggcta 2394541 ccatggtatc aacgatagga acgcccgaaa tatctaaaaa taaatacgag agctttaacg 2394601 ctgagcactg ctccagcaca gactccaaaa tcgtcctcgc tctgtgcgta tcaatttcac 2394661 cgacaagcgg aagaatccca attccatcag taatcggcat aatcggcgca ctcaattcat 2394721 taatcatttc tttttgcgcg tttaattgta tcatggtcac ctggtgatat tcttccgtaa 2394781 acacttcgat gatctcatca atgttttgat tcaagatccg gctccactca taaaattcct 2394841 gaatgctgat gtcttgagaa gaagcttcgc tgaatttatg aatccattca aacatgatgt 2394901 gcctgaaagt gttaaactgg ccgacacttt gtgtaaccgt cacttcatga acggcacggt 2394961 ctctggcgca ttgaagagac caccggttga gctcatcctc tacgtcttct tttctaaggg 2395021 attttgctac gatggtcacc aataattcat gctggtcttt taacttttgt tctagttttt 2395081 gctgatcttt cgctgaatac agccagctgc cgtttgacgt acaaacttcc agccattgtt 2395141 gcgtaatatc ttttttgtgc tctgttaagt gctgatcaag agctatcatc ttaatgagtt 2395201 acctcctgtt tttgaaaaat gtacgctata tatgtataac gcgtctgcct ttacacatac 2395261 tatgtttaga ttcaatgggc tatagccaag cggtaaggca atggactttg actccgtgat 2395321 cgttggttcg aatccagcta gcccagtttc tgaacaggtg aaaaaccgaa gataagctga 2395381 ttcgtataaa tcagcggatc ttcggttttt catcatgcag attgatgaac cgttttcttc 2395441 ttcgataact tcaacagttc tcccgggtta taaccaatca ccagcttttt gttgtctact 2395501 agaatcgggc gtcgcaaaag cttcggcttc tcgattaaaa gttccagcac ctcatttacc 2395561 gtcatttctt caatgtttaa atttaaattt ttgaaagtct ggcttcttgt cgccaaaatt 2395621 tcatcaattc cttctgtcgt taacgataaa atgtacttta attcttctct tgtcggggtt 2395681 tctctgaata agtgccgttc gttaaattca atttgatgtg ctttaagcca atgttttgtt 2395741 tttcggcatg acgtgcagct tggatatgag taaaaagtta attgttgttc cattcgtttt 2395801 ttcctcctca gttaaccatc tctttgtaga ataactaccc ggatcatttt tcatttaaac 2395861 catttacaga acttttttcg gattattttt taaaaaacat tcatacaata gaaaacacaa 2395921 tcaaagggac aaattccatt tgtatattaa taatgaaaat gtttacattt ctaggtgtga 2395981 tctattataa taacagtcag agggactctc gggaggggat aaaaatgaat cgcatgttcc 2396041 gggtgttagg attttggacg ggaatttttg cagtcatgtt ttatttaggt gatatgaaag 2396101 atgcttccct tttatttttt ggacagacga tcttatttgt gtttctatcg tatttgaact 2396161 taaccgaacg catgtatatt tatatttttg gcgcttattt aacaattttc ttcgccggct 2396221 ttacatatta ctcaattttt attatggtgc ccggcggcgg aggccattaa atgcagaaag 2396281 agacaaacct tatcggtttg tctctttttt tacaatgaaa acccatttaa aaacggattt 2396341 tgatcctgct cagtcagtac gtctgtttca ggtccatggc cgcttaacac cagcgtgtgt 2396401 tccggaagcg taagcagttt ttcatgaatg gacgtcagca gcgtctcttg attgccgcct 2396461 attaaatccg tacgtcctat accgccttgg aacaagacat ctccggaaat gaccaagtct 2396521 gcatctttca cgtagtaaga cacactgcct ggtgaatgtc ccggcgtaaa taatgtttcc 2396581 aaatgaaacg gcccgatatt caactcaccg tcgccttcaa ttagatgatc tgcaggctta 2396641 gctgtgactt ctatccctcg cagcatgccg gagccgttta aagaagcgtc cgcaagccaa 2396701 tttttttcat tttgatgcag gtaaacaggg atatcccatt tttctctcac ttcatcaagc 2396761 gccccaatat ggtcaaaatg ggcatgtgta agcaaaatgg ctaaaggcgt cagccctttt 2396821 tcttttatgt attgattgat tttatgtccc tcgccgcccg gatcaaaaat cagacattga 2396881 tcatcactga tgagaaaata tgcgttcgct tgaatcggcc ctactggcat tcgtctccat 2396941 ttcactatta tcacctcttt cttttttatg ctcttattat gagggttttt gaaaaaagat 2397001 tcaaacaatc gcaatgaaaa cgctatcgac aaacctataa aaaacaggta gaataaaact 2397061 ggaaagaatt gcaggttttt caatgtaaag ggggctgtgt tatgttactt gtcgtgattt 2397121 tcggccttgt cgctcttttc gctttatggg gagtcttgcg ttctgttaga aataaaaata 2397181 tactcgggtt tttattagcc ggtgccacct tatttgtctt tggatggttt accgtgatga 2397241 ccgtaataaa cagcgggtat ccaaccgcac attaaaacct gtatccgatc ggatacaggt 2397301 ttatttttat ggctgtaaat gtttattgac actttctatt ttgctctcaa gcgtcgtttt 2397361 tttgtcacgc ctgtcatcga tacggatatt cgttgccact ctgtgcaatc ctttttgaaa 2397421 tggcgcttcg tgaattgcct gaataactgc aaaaaggtca ctgagttctc cctcgatcag 2397481 cgtattcatc ggtgtcagct gatatttgat tttcccttct gcttgatatc cttctaatat 2397541 cttttgcaca tcggctacgt aagcactgac actgggtgtt tccgtaccga ttgggataat 2397601 ggttacatct gcgatagcca tcgttattcc atctcctttt gatcaatgat gagttgcttc 2397661 gtttcatgtg atttcaataa aataatttgc tcaaaatgaa agccgtataa cgcatatttc 2397721 ccgttcggag atatttgaat cggctccatt tcccgcagag acacaagatc ttttgtctct 2397781 cccgatgcta cattgattgc tgcgagctta tatgcatcgc cgctttgttt gaatgtataa 2397841 aacaggcctc ctgcttcatc atagtcatac tccattggag ccaaacttgt atatttcgct 2397901 tggagcggcc atttcgctgt aacaggtgat gttgattgcg gcgttttaaa ctgatacgtc 2397961 ccttttcctc cggaagctga tttgacagta aaactcattt gatggaaaga atcgaagaat 2398021 agaacgttat cctcaagctt ctgttccgtc ttagaagctg tatcgaacgt atataaaggc 2398081 cctgttttat cgtctctacc ctcttttaca taatcaaatg tatttttgga tgtccaatga 2398141 atgaacggaa cctgtactgg gcttaagaaa gattcgtctt ttttagcatt cacctgatat 2398201 gtatggaaat cccagttttc attgaattcc gtcaccatca tttgataagg atcatactga 2398261 ttccaagcag cttcaagctc atacgtttcg taatcttttt cgtaaagcgt ctctccttct 2398321 gcattaagca aaaccactgc cgtcttttgg ctatgtgtga tttgcagcag aatcatctgc 2398381 tccctcgcat tgatttgaac atcaacgatt tgaccatccg tttgatagag ctttttcgct 2398441 ttgcctgtaa agatgcggta cgcaaaaagc tctgttttcg tcggattaga cgcagtatat 2398501 aatattgtgc tgttattcag ccagccttcc gccccatccg ctttttccgc ggaaagcggt 2398561 atgatgtctt ttttctcatc ttttgccgcc gatgcctgtt tttgctgctg atgagatggt 2398621 tcgcatgccg ataaactaaa cagcaatacc gccagcagaa taaaacaaac tgatctcatc 2398681 agcattcccc tccgatcatc tttattctct catatttgct tcggcagaaa aaagaaaaag 2398741 tttcagttac tcatgaaaaa ataacgccct ccacaagata ccgcttgtgg cgttatatat 2398801 gtgtgaaaac tgctgaaacg gcaaaggatt ttggcctttt ccaagttcca ccgtataccc 2398861 ttccttaaaa taatggtgaa taaaccaatc acgaaatcca gcatagctgt ctatatccct 2398921 tactccctta taaatgttcc cgcttaactc ctcaaactcc tttatgacgg cagcagattc 2398981 ctcaggctca aggcctttat agccccaata aatttcttct ccttgagtat gaagagccag 2399041 cagtctgtca ggcggattct ccgtgatcag ccggtacatc gcaatagatt ccggctccgt 2399101 aagcggagag attcccggaa aatcgcggta gctgggtgct gtcggttttc ggtatttttc 2399161 aatttcccat aatgatggaa attgtttatt taaatcaacc ccgtttatat tcgccttcca 2399221 ttcattaaaa tttggacgat gttcatttag cctttcgagt tcatctcttc tggctcccat 2399281 gacttctgat ccgtttaaaa caagatcaac gccatccgga ttgacaagag gaacgaggga 2399341 taaggatgtg ctgttaaaca gctttatggg agaaaagcca aagaaaggcg aattgcagca 2399401 taatgacata cagtattcct taaaccattt tagcaggaca gacgttgtaa tccactcatt 2399461 cgcatgaaat gacgcgttca tatggacctt ttttacggca tgctccccac cagccttcag 2399521 ctcccagata ggcctgccga gtacagaacg gccaatttcc cggcatgaga caaacggaaa 2399581 aacatcaata atcttcttta tttccttttc aacagctgaa tcatcataga ttttctcttg 2399641 ctcaatccag ctatctgaaa gtttcagctg ccgaggctgt aaaaagcgct ttatgtcctg 2399701 aatggtttga agctctttgc cgctatgctc ctctatcaca taaccagggc aatacaattg 2399761 atgtttttgt gcggagcgat ttgcactttt aagcaattcc tcgtctatct tcagttcttt 2399821 cgccacattg gccaaattgt tcttgatctc aggtttcacc gtaataaacg ccatcatcat 2399881 cccccttttt tgttactata tgacagcgta tttaaaaaaa gaaagcctcc cgctcacttc 2399941 gatgcgggag acattgtgat tatgatgcct gatcaagcat ttgtttttct ttccgctttg 2400001 acgaattgtc cagccttttc tggtcataaa atcgcaacaa atccccataa atgatttcat 2400061 cagaaagtga tagctcctgt tttgctttat cagcaaatgc ttcacattgt tttgtctctt 2400121 ctaacggttt tcccgtctct ttgtcataac acgcaccgtc tgtataaaca acctgatctg 2400181 tgataaagct cccgtcccgg agcaccgtga agtccagttt ttcgtctgaa agcagatcgt 2400241 tgccgaattg aatttgatct ttcgtatcaa tccctaaaag attcatcagc gtcggcctga 2400301 tatcaatctg cccgcctact gtttcaatgg tttgcggctt tttatcagta atacccggaa 2400361 tatgaatgac cagcggcact ttttggagct gtacctcttc aaatggggtt atttcttttc 2400421 ctaaaaactg ccccatcgct tcattatggt tttctgatat accataatgg tcaccatata 2400481 atacaataac agagttgtcg tataacccgt cttccttcag cttttcgata aaccgtttca 2400541 gcgcctcatc ctgataacgc actgtcggaa aatatttatt tagcgtctgg ctgtttgaat 2400601 catattcatc aatcaattga tcctcttcat caagatcaaa cgggaagtgg ttcgtcagtg 2400661 taatcagcct cgagtaaaac ggctgaggca gatttttcat cagctctgag gactgctcaa 2400721 aaaattcttt atccttaagt ccccagccga ctgaattttc gtcagttaca tcatacgagt 2400781 taatatcaaa aaacgaatca tatccaaatg agtcgtacat taaatcacga ttccaaaagc 2400841 tcttattatt agcgtggagc accgctgaat agtatccgct gtttttcaaa atttcaggag 2400901 cggccatata ttgattgccc gcattcgtaa aaaatacggc acctcgtcca agcggataca 2400961 gtgaattgtc cacgataaat tcagaatccg aggttttccc ctggcctgtt tggtggtaaa 2401021 cattattaaa gttgtagctc tgttttataa agtcattcag aaaaggcgtg atttcttctc 2401081 cattcaattt ttcattaatc acgaagcttt gcgtcgactc taaggatacg agaatgacgt 2401141 tccttccttt tgcagcgccg aataagcgtt tgttggcatc cttcgcatta gcggttacgt 2401201 agttttcaat ctccgtcagg ctgttgctgt ctgccaacgc tctctgtgcg gattgctttg 2401261 actgaagaac gccatcgtaa atatgaaaat taaacaggct aatgttttta acaagcattt 2401321 ctctgtcaaa tgagcgtgtc aatagctgag gtctttccgc ctcagacaag cccaggttga 2401381 agaaataaac agaagcaacg aacaaaaaat aagccgcccg ttcatttttc gttgagggaa 2401441 tgtccgattg aaaagctttt tgccggatgt gaagccatat taaaaccgca atatctacag 2401501 ctaataggag gtctgtcggc tcaagaagtg ttccgatgct gcttccgaga tcacccatat 2401561 tgctcgtttg aaaaagaaca gggattgtta agaaatcatt gtaaaaacgg taaaaaacca 2401621 tatttgccag caatacaaac gtgacaagac agctcatcgc gataatgtag cgatttctgt 2401681 ttttgccttt taaaaacagg ctgaggccaa aaataagcaa caaaaaactc aatgggttga 2401741 taaacagaat aaattcctgt gttagattgt cgattttaat atgaaaactg gttttgtaaa 2401801 cagcatacgt tttcagccac atcaataaaa tggcaatcag cataaatgaa atcttcgaaa 2401861 aaaacgtttt tcgcatttca acctcctatg cagcacgctc aaaaaaatca gtctattccc 2401921 aacattctca ttaacacatc aaattaaatc ttaacctgag cacaacaaaa aatcaatttc 2401981 atttacacaa ttttaacaat tttgatgttt cagccattca tttttagcga tccaagcgcc 2402041 tccgataacg ccggcatcat ttccaagtgc tgcgattgaa atatcagcag cttgggctgc 2402101 ccgcggaaac gcgcatttgc ggaatgtttt ctcgactttt gatctcagca gttctccggc 2402161 tctcgatacg ccgccgccaa gaacgatttt ggatggatta agcgagcttg ccaaatttcc 2402221 gagcaccaaa ccaagatgct tggctacata atcaaccacc tcaagggcaa tttcatcatt 2402281 ttcacccgcc gcttcaaaca catctcgcgc tgacaattgt tcggttgctt ttaaacgtgt 2402341 cgtcttttta gcatttgcta ttttttcttt tgcaattctt acaattccgg ttgctgacgc 2402401 aattgtttcg atacagcccg ttttgccgca gttgcagggc gctccgcctt cagggatgct 2402461 gcaaatatgg ccgatttctc cgccggcgcc atttatacca tgtacaattt caccatttgc 2402521 aatgatgccg ccgccaactc ctgtgccaag cgtcacgaga atgacgtctt ttgcgccatc 2402581 acccgctccc ttccacattt ccccgagcgc agcaatattc gcgtcatttt ctataacagc 2402641 tgggatgccg gtttctgtct ccagatggtt tttcaaagca taatttttcc accctagatt 2402701 tactgtttca taaaccactc ctgccgccat atctacaggg cctggtgcac ccattccgat 2402761 gtatttgatg atgtgcttcg gtttttgcag ctcatccagc ttgctgtcga ttgtttttgc 2402821 aattgtgaca gtaatcgtgt cgccggtttt atctgtcgga acttcccact tatgctgaat 2402881 ttcgccatat tgattaataa aagcgagttt aatcgtcgtt cctcccaggt caatgcccgc 2402941 aaaccatatc tcgtccattt ttatcacctt agcctttata aaaatctctt ccgttttttg 2403001 tttgttccaa ttcttttcga aggacagctg ccgctctggc ccactgctcc ttttcaatca 2403061 tgtggttcat gtataattcc tttaattcat ccagcataaa ctcaatttca agctctctgt 2403121 ctccaaaata aacaatgtgg ccaaacgttt ttaacagctg ctgcacatca taaaatgtat 2403181 tcattttcct caccatttct tgaacttaac tatcataagc gtattcataa ggaagcggtc 2403241 agtcaagaag aaaacgctga caaaaaagcc agcttccttt ccatattcca cctctatgat 2403301 tctttattgt tttcaatttg ccgctgcagc tccttgtagc gctgctcctt cggcttcagt 2403361 ttcacagccg tctggatggc cttttctgct tgtgcaagct catttttttc cgcatacaat 2403421 aacgctaaat tgtaatagga agcatggtct ttaggttctt ttttcactgc tcgttccaaa 2403481 agggaaaccg cctgatcata ttcgccgatt tgaatatcag aaacagcaag aattttcaaa 2403541 agatcggcag aggcatcttt ttgcgctgct tctccgttca gcaattctgt tacttcttca 2403601 tactttcctt cctgatacag ctcgcttgcc tgctgaatca gcgctgactc ctggtgtgaa 2403661 ggcgaatgca atccgtaata taaaaatcca acagccaaag caatcagcaa aaccgctgac 2403721 aacaatcttt ttccaaaggc tccggcttta ggcaacccca gtgctgctgc agcgaaaaag 2403781 ccgccaatca agccgccgat atgtcctgaa ttatcaatat tcgaaaccgc aaaaccaaag 2403841 cccagattga tgataataat gacaataata ttggttccta tagttcttaa aaacattttt 2403901 cgattagaca aagcaacata cagtaatgca cctaagcatc cgaatatggc tcctgatgcc 2403961 cctgccgaag gatacgggct gaacacaaaa ctcgcaatcg aacccgtaat gccagcagcc 2404021 agataaatca gcaaaaatct ccccgatcca tacatccgct caaccgctgt accaaccgac 2404081 cataaagcca gcgtattaaa agctaaatgc gctatgccga tgtgaagcac gatcggtgtc 2404141 agaagccgcc accattctcc ttgtgcaatc aggctgtttt cttttgctcc aaaagccacc 2404201 agtgtctccg tattagtgct gcctccgttt atttcgagca agaaaaacat caggatctga 2404261 agcgcaataa ataaatatgt aaaagtcggt tttccgtttt gaaaaaccgc cgcttcagtt 2404321 tttctctgtt cttcttgttt cagcactagc gaaaggaagc gttctcgcgc catttgcgcg 2404381 ttttcaaacg aagcgtgttc ctctgaacaa tcttctgtac gaaatgatgg aaaaaccgct 2404441 tgaagatcat ctcgaagcat cgttcctcta acgatcgccg gctcaactga cacagttccc 2404501 ttctcaaaag ttttttttgc aatctcttcc cagtcatcaa ctggggcttc cgttgaaaaa 2404561 aacacgttca gcagcttcat ccttcgtctg cccaattgat gtctgactcg ttctactcgt 2404621 tcggcctgct cttcgatgtc tctaaccatt tcttgacgga aatcaagatc gtgcttataa 2404681 agacgaacta gatcatgaga ggacttgtcc ggcgcttcca gccatatttc atctgactca 2404741 ccggcttgta tgacgccata cccgctattc accaggtgcg ccgcaatttt ccaatatgta 2404801 tactccagca aaaacatgtt taccgctcca atagtttttt ttcattataa cagctggcgc 2404861 tccgaaacgc ctactgaaag caaaaaatcc cgtttttcac gggattttag aaagcttgct 2404921 gtataaactt attgcggata aatggaattc ttaaaaacaa atggataaaa gaccgcctga 2404981 ttcctggctg gctgagtaca gtattcataa gacggtagcg attttgataa aacatgacgg 2405041 cagaaaccgc gaaaatggca tatatcaaaa gttttttcat gatatccctc ctgccaatag 2405101 ggtttgttat tctaccttat ttattctcga ataagggaca ggaaagttat gaaaaacaag 2405161 aaataatccg atcctctgtt atcagcttat gtaccgggat gtcatgcggc agacggggta 2405221 cgtgcgcaaa caactggcac tccaaaagca aagagactgt cttcccttca tattcactta 2405281 aatagcgatc ataatagccg cctccaaagc cgaccctaaa cccgttaaca tcaaaacaaa 2405341 cacccggaac gatcatcaag tcaatttgtg atgggtttac ttcttttgtt ttttcaatta 2405401 ccggctcgag cagtccggcg tacacggttt cgagctgatc atcagtctga tatgtgcgaa 2405461 attgcatttt cttcgtgtcc ggatggcatt ttgggatgca aacttgtttc ccttcttccc 2405521 aagcctgctc aatgacagga cgcgtcggta tctctaatcc tctggaaata gtgacggcaa 2405581 tggtgccggc attttgccac tccggcagag aaaacaagta cttatacata cgttccgttt 2405641 tttgaagaat atcttcattt gataaagcag acagtgcctc cagcgtcttt tttcttaatt 2405701 gtgatttcat ctctcatccc cctcggaata gaaaaaaagc cagaaccttt ttcaaagctc 2405761 tggctttttt cttacacctc aaacagcaaa gctgttattt tgtttcacgg tgtaacgtag 2405821 attttttatc acgtgggcaa tattttttaa attcaacgcg gtctggattg ttgcgtttgt 2405881 tctttttaga aatatagtta cgctcaccac attcagtgca agccaaagta atattaacgc 2405941 gcattatttt ccctccaaac taaaatcatt tacttattca gacttatata taataccact 2406001 ataatggacg gaatgctagg ctgtttttca atgaattgct gaattattga agatacgctc 2406061 ataaagctgc aaatatgatg acataatgag tcgggggtgg tggagcttga acacttgttg 2406121 tctgccagct tcttttatcc ggcgggcttt ttcccggtct tttaaaaaac tgtccagcag 2406181 atcagcagct tcctgtacga gcgtaaaatc agcgatgatt gccgttttgt catgaaccgc 2406241 ataatcacaa aaaccacctg actgagaaac gacagtcagc acaccttgtt ccatgctttc 2406301 ttgcgcggca agcccaaacg gttcataaga actagggaaa acagccattt cacagtgaga 2406361 cagtaacgtt ctgatatctt tcctatttag aaacggcaga aacatgacgc gatccttcag 2406421 gttatatgcc gcagccaatt tctcatagca ggacagagac ggcccctccc cagccagcac 2406481 tagatagagg tcaggctgac gctgcttcaa gatggcaaac acctttaaca gctgcgataa 2406541 tcctttttcc ggaacaaacc ttccatatga aaagaggaat cttctattca tgcttctcgg 2406601 gattttcccc ttctcttcct ccatagatgc agggcttggg ataacggtta ttttcttatg 2406661 tgccgcctta tcaagagacc gcttcataaa tgtgcttaat acgatcaatg catcagcgga 2406721 ttctataagg agccgttcgg tcatgagcct gtatgggtgt ggggcttctc ggcacacctt 2406781 cttcctttcg ctttcaagac cgtggattgt cgcagcaagc ggaaggccaa gccgttgttt 2406841 caaatactgg gcggcagggg cagttgtgtc atcatgggca tgaatcagat caaagcgttt 2406901 attgtgtgat aacacatggc gaaccattgt aaagttagca tcagctatgt aatcttcaaa 2406961 cttcgcatac gaaaacagct gcccgctcgg agtaaaaacc gtaatgttga tatgagggtt 2407021 taaataggaa atgaggcggt ttaaatggac accgagcccg cttttcggct catcgggatg 2407081 ttcgggtgaa agcatgagaa tgttcaccgt tctttttccc ctctcccata acaggtgtat 2407141 gcagaaaatt gcgcctccca cctggtgtgc gcttcttcaa tctgaaaact gtttatatga 2407201 cgaatcccat tttcatcaag atagatgtcg tctgtaccgg caagcttgag agagacattc 2407261 attgaattca caattctgta ttcagcccga tatacagcat caccagccgc ctgtctaatc 2407321 gtccattctc ctttatcata cgttgtgcgt tttgtcctga cagcttcaat gtcttttctt 2407381 ttgatgacaa tgcgcaattc ttttatcata tcctgcgttt tttcgaaaag gaccgcttca 2407441 gccagccgca ttgtttcttc tgagatttcc cagcttacgg tcaaggtgtg agcgttttga 2407501 atgattatgt cgaatgtgtc cctaaaaaag gaaagcttat gtcgtatatt atagggaaat 2407561 gggtgtttat ccatggactc ctaacattct cctttccaat cgttcacttc gtgttcctat 2407621 taaaccatta catgaagaag aagcgaagaa agatttctcg acaaaatctc gtttttttcg 2407681 cgaattcctt tagaaactat tggttttatg gtataaaaaa gaaggataaa aaaagaatag 2407741 aaggtgatga aacgtggaaa ttgctattat tgcgttgttt atcgtcagta tagcgctaat 2407801 tgcattctca tattctcaaa gagacccgat gaaagatgta gaacaggagc tcgaaacact 2407861 gcagctttct gcgatgcagg aaatttacaa gctcaaaaag aaaatgacag tgcttgagga 2407921 agaattactg gaaacaaacc ttgtcattcg caaatcaaag cagaacgaca tcaatcaaaa 2407981 aatcgctaaa caaatacttt ctaaatataa taacggtatg tcagctgaag cgattgctaa 2408041 agctgaacat gtatcagtgg aagacgtgaa tacgattatc aaagataatg agaaggtgct 2408101 cgtatgacaa aacggggcat tcaggcattt gctggcggca tcattttagc gacagccgtt 2408161 cttgcagctg ttttttatct gactgacgaa gaccaggccg ctgctgtaaa agataataaa 2408221 acagtaaccg aacaagacgt gaacaattat cttgattcta aaaaattggt ttctgtcaac 2408281 cgtgatgaat atcaaaaact tctcgattca aaagagaaat ccttaaacaa tgacagcggc 2408341 tcagacacga aatcagacaa agtcaaaacc tacaagctca ccattaaaga cggcatgagc 2408401 acggcggatg tatctgctat tcttgaaaaa gagggcatta tctcttcggc tcaagacttt 2408461 aatgactatg tcattgatgc cggctatcac aaagaaattc gtgccggcga gtttaaagta 2408521 aaatcagaca tgagtttcaa aaagatcgta aaaacgttaa cacgataaaa aaacaggctg 2408581 actcagcctg tttttttcat ccaaactttc ctgaaatgta atcgagcgtt ctttggtcct 2408641 tcgggttaga gaacatttta ttcgtattgt cgcattcaac aagctcgccc atgtagaaaa 2408701 aggcggtttg atcagaaacc cttgctgcct gctgcatgtt atgcgtgaca atgacaattg 2408761 tatatttatc tttcagctct agaatgagtt cttcaatttt tctcgttgag attggatcta 2408821 gtgcagatgt cggttcatcc atcagcaaaa tatcaggatt ggtcgcaagt gctctggcga 2408881 tgcaaagacg ctgctgctgg ccccctgaca gcgaaagagc ggacgtatgc aatcgatcct 2408941 tcacctcatc ccataacgcc acgtctttta atgacttttc cacaatttcc tgaagcttct 2409001 tcttattttt ggtgccgtgg actctcggtc cgtaagccac attatcaaaa atagattgcg 2409061 gaaacggatt ccctttttgg aataccatgc cgatattttt tcgcaaatcc acgatgtcca 2409121 ctttatcctt taaaatgttg ctgccattat agttcagctc acctgcaagc tttacattcg 2409181 gcgtcatttg aatcattaaa ttcaatgtct tgataaaggt cgatttcccg catccggatg 2409241 gtccgataat cgccgtaacc tcattttcat aaatgctcaa attgatattt tttaaagcat 2409301 gatgctgccc ataccataag ttcattccat tgacttgata tacttcctgt ttcattacag 2409361 cttcggtagc aatactcatt gccgccctcc tatccgaatt tcccgttaat ataatcctct 2409421 gtcttttgct ttttcggact cgtgaaaatc tgttcggtct gtccgtattc tacaagctcg 2409481 ccgtttaaaa agaatgccgt ccggtcagaa acccgcagag cctgctgcat attgtgcgtg 2409541 acaataataa ttgagtattc tcttttcaat cctgtaatta attcctctat ttttgcattt 2409601 gaaatcggat caagcgctga agctggttca tcaagcagaa gaacagccgg cttcatcgca 2409661 agcgttctcg cgatgcataa acgctgctgc tggccgccgg ataacgagag tgcggatgaa 2409721 tgtaaacgat ccttcacctc atcccagagc gctgcttttg ttaaactttc ttccacaatt 2409781 tcatctaaaa cagctttatt ccgctctccg gcatatttca atgcatgtgt gatattcgca 2409841 tagatcgatt tcggaaatgg atttggtttt tggaaaacca ttccgatttc tcttctcaag 2409901 ctgacaacgt taatattgcc gcccaatata tttaatccct cataaaggat ttcaccttcc 2409961 gctcttgcag atggaattaa atcgttcatt cggttaatat ttctcaaaaa agtagatttt 2410021 ccgcatcccg acggcccaat taaagcagtc accgcatttt tttcaatatc catgtttaca 2410081 tgatgaacgg cttgtttatt tccgtaataa atggacagat ctttgacctc aagcacgtgg 2410141 ttctgcttcg gaacaataac agctcgctca ggtttttctt ttaccatttg ttcagacatg 2410201 tttttcgcct ctttccgttc taatttgccg taagcttttt gtagatcatc gtgccaagcc 2410261 atctcgccgc gagattaaac acaagaacag aaatcaccag cacggcagaa ccaccgttgg 2410321 caatcgcttc agcatccgga atcattcctt gtgtattgac gttccaaatg tggaccgcaa 2410381 gtgtttcagc gggcctgaaa atattaagcg gtgatgtttc cgaaaacggg ttccactccg 2410441 taaaattaag acgcggtgtt gtcaggcctg ccgtaaataa taatgcggcc gcttccccga 2410501 acacccttcc tgacgctaaa attgctcctg tgatgataga aggaatcgca cttggaatta 2410561 aaactgtttt tacggtatgc cagcgtgata cacctaaagc gagagaggct tccttcagat 2410621 ctttagggac tgaacggatc gcgtcttctg tcacacgcac catgacagga aggttaaaaa 2410681 cagttaacgc aagcgctccg cctatgatcg tataacccca gcctgttaag ttgacaaaca 2410741 tcaataatcc aaacatccca atgacaatag acggaagaga tgaaagcacc tctatacatg 2410801 ttctaatgaa gtcagttact ttgttattag gcgcgtattc agccatgaag actccgccgc 2410861 ccacaccgag cgggattgta atcagcattg taataaacaa aatataaaag gagttaaaca 2410921 gctgatctcg tatgcctcct ccagctgcaa tggcgctcga ctttgttgta ataaattgaa 2410981 aactgagctg agaaacaccg tttataataa tataggaaaa caaacctact aaaatggcag 2411041 cgataatggc tgcacacaaa ccaaacattc cggtcgccag tttatctgtt attttgcggt 2411101 tcattacact ttcctcctag atgacaagta gcgaataagc aggatgaaca agaatgacat 2411161 caccagaagc acaagcccca ttgaccacag cgtattgttt tcaacacttc cgtatgtggt 2411221 gtggcccata ttcagcgtga tgatcgttgt cagcgttccc gcagtgtcaa acgggctttc 2411281 cggcaatact cttgtatttc caatgaccat ctgaacagcc aaagcttcac cgaacgcccg 2411341 agccatgcct aacacaacag ctgtcatcaa tgttggaaaa gctgcaggca caagtacttt 2411401 tctgatcgtc tgccatcttg tggcaccaag cgcgtaagaa ccctctcgta aactcttcgg 2411461 aagagaagcc attgcatcag cagaaatcga tgtgatcgtc ggcagaatca tgacggaaag 2411521 gacaatcgtt cccgccaata aactgtgccc tgttccgctc gatttgaact gggcgataaa 2411581 cggcaccaat actgtaagac ctatgaatcc ataaacaaca gatggaatac cgactaaaag 2411641 ctcaatcacc ggctgcagca ctttctttcc ccaattcggg gcaatctctg tcataaaaat 2411701 cgcacctgca atgccaagcg gcgcagcgat tagagcagaa agaatcgtta ctgcaaatga 2411761 gccaaaaata aatggcagca ctccgtattt cggatcacta tctgtaggat tccaatttaa 2411821 gctcgttaag aattcaattg ggcttacacc atttacaaga aaagattgca gccccttaac 2411881 gccgaggaaa atggtaatcg caacagatgc cgcaatcata atcagtgcac aagctgtgac 2411941 tatcattctt ccccgaactt catccaattg ccgattttgc ctagagctga ttaagcgctc 2412001 gctcacagac atattttctc tattgtttat cattgtttta cactcctatg aatgtgttaa 2412061 gaggagaaac ggttgtcccc gcactcctct ttttattaag atcagctttg cttcccgttg 2412121 gcatcacgtg tcactttcat atcagtaacc ggaatgtagc cttggtcagt aacaatgctt 2412181 ttttgaatgt cttcactctt tagataatca agaaattctt tagctaaacc tgtcgcttca 2412241 ccttttgtat aagaatgttg ataagcccag atcggatact cgccagttgc tacatttttc 2412301 gcttcaggtt taacaccgtc aatagataga gcagttactt tgtcatctgt taaatatgag 2412361 aatgcaagat atccaatcgc tcccggagta tcagcaatga tctttttcac cgtgttggag 2412421 gaatcttcag taatgccttc tgcaggctcc gctccgtcaa gcgcatattt cacaaatgta 2412481 gcacgtgtgc cggaagaatc agggcggttt acaagtgtaa tcttttggtc tttgccgccg 2412541 agctctttcc agtttttgat tttgccagtg aagatttttt tcaattcatc ttttgaaata 2412601 tcctttacac cagcatcagg gtttacagct gctgccatac caactacagc gacttgatga 2412661 tcgacaagcg cttttgcatc gatgccttct ttttcttcag caaaaacgtc tgaattcccg 2412721 atctgaacag ctccttcaga gacttgagaa agccctgttc cagaaccgcc agcttgtacc 2412781 tgtatatcag catcagggtt ttcttccata aatttttccg cggctgcaag tactagtggc 2412841 tgcattgccg atgaaccaga aatggttaaa gaacctgatg ccttttcttc tccttttgca 2412901 gaatcgctat tcgatttttt actttctcct gcatttccgc atgcagctgc aatcatcata 2412961 aaagcagcca tcagaagcat aagcaccaat ttgttttttt tcatttcctg aattccccct 2413021 gcgtataatg tgtaatttgt cctacacgta tagagtaaag gttctatgta aaaagggttt 2413081 gaaccgaatg ttaaggtttt gtaaatcagt gcgttttttg tataaaaaaa acgcccacat 2413141 catgtgagcg ttttttttta gttatcagaa gacgttgtgt tttctgcatt ttcttcaatt 2413201 ttgtctttat tcttttgctg agtaccttct ttgtcctgct tcgatttcag ctcaaaatat 2413261 ttatccatta cttccctgcc gatttcgttt gtaattgagt atctttgatt gtaatcaatg 2413321 taagtccaag gaactacgac agaaatagca atctcaggat tgtcagctgg tgcataagcc 2413381 acaagcgtcg tattataagt gtctgttcct gtttttgatt tatccggtcc gtcgtaaaat 2413441 gattgggctg ttcctgtttt tgcagctggt ttatacgatg ctgaagccag ttgacctgca 2413501 gctgtccctt tagtggcaac ccgtctaaaa ccggcttgga cctcttcaat atagctactc 2413561 ttcatatcga ctttattcaa tacttcaggc tgaacagaat caacgactgc gccgatccct 2413621 tttttcgcat ttgaatctct gacttccttt acaagctgag gcttcatgcg gtagccacca 2413681 tttgctatgg tggagacata ttgagccaat tccagcggtg tataagtatc atactgtcca 2413741 atggcgaaat caagcaagaa accagataat ctgcttgtac ctttatatcc cgtcatttca 2413801 tttggtagat caattcctgt ttttactcct aatccaaatt gactgaaata atttctgaag 2413861 gtatcaaatg cagaagtatc caaaggcaat gcttggtgag gtttatattc acctttacca 2413921 actgcaattg ctgttttaaa cataaaaacg tttgatgact tctctaatgc agtttgaata 2413981 ccaaccggcc ctaagttttg ccaagatttt ttccctcttt tatcctggcc gatatacaat 2414041 ggttcatcct taaatacagt attcaaatta atcgctccag tttgaagacc ggtcaaaacg 2414101 gttgcacctt ttacagctga tcccatagcg taggatgaag tcatggctcc taatgcataa 2414161 tcatcaaact tataggctcc attttctcgt ttaatctgct tccctgccat tgtcagcact 2414221 tcgccgtttc tagggtccat catgacaacg aatgcacgat ccaacaattc ggtactaggt 2414281 cttgctttag cagctttaag ttttttctca ataatttttt ccactgattt ttgcaaatca 2414341 atatcaattg ttagtacaag atctttcccg gctttgcctt cagataccgt ttttgttccc 2414401 gtgacattgc cttttgaatc tgtgatattt tcgacttttg ctttttggcc ctgcagaagg 2414461 ctttcatatt ggtattccag atagcttttt ccgaccctgt catttcggct gtagccaagc 2414521 gacagataat ggtcgagcaa gttggacggc aatccttcat tagagctgga aacacttccg 2414581 agcactgagc gaagaaggtt tttataagga tattcacgtt cccaatcgga cgtgacatca 2414641 acacctggca gttcgtctaa atgttcactt accactgcca tttccttcgc tgatacatct 2414701 tcgtttttga tatattgagg ggtcaatgca tagcccgaat ccatctgtct tttgatagca 2414761 aggatctgca tatctttatc cgtcaattca ttcagctgct tatcagtaat ccgttttagc 2414821 tgaagctggt ataaatcgtc atcggatatt tttttgtctt caacctgctg tctttcttta 2414881 gagctaatga gctttttcgc ttctttcggt ctagtcaaaa tccaataatc ttttttatcc 2414941 cgttctgtta ctttttttgt atcgactttg atcatgtcag acagcttttt tgcgatcttt 2415001 aagcgctgtt cttgcgtggt cgatttagat ctcgtgtatg tgattgcatt taaagcctta 2415061 tttgtcacaa tggcattaaa gtttcgatca taaattttcc cgcgtggtac cgctgagctg 2415121 acttcacttt gttcctgctt attcgcttgg tttttgtaat catcaccttg cacgatctgc 2415181 ttgatgccca gttccacaat aatccaggta aatataacaa aggcagctaa aaataaaata 2415241 ttcagccgga tcggaagcga cttctttttc tctttatgat tttgcttttt tggtttattt 2415301 ctcctcataa catcaccttt tctatttaca gaaagaaaag acactcaagt aagagtgcca 2415361 gttttcattt taaaggtttt ttcgactttt ttctacagat aacccctttt tggcaaaaaa 2415421 attatctctc gccttttaaa agggtcggtt ctgttacccg tttttggccg tcttcttcca 2415481 tggtttcatt ttccccttct ttctccttaa aacgaatatc cttgacaaag taataaatca 2415541 aaggatgtcc tatacccaat atcgcaagtg acaaaggaat tcccacatcc tctttcagaa 2415601 gggccacaat caggagaaag cacaaaatgg aaacaattct gccggcgttc aagaacattt 2415661 ctctaagcac gatatattca attcttgctt ttctggcatg cctcgcgcgc cctatcacat 2415721 catatgtaag tgatacatat ggcacaagca acagaggata gccgatggca ataaaaacgc 2415781 cgtacgttaa taatgtcgaa aagctcatat ggaacagaat caaaaacagc gcgccataca 2415841 aaataagtcc gcccagcaaa atcgattttt ttctcgcctt tttcttaatc agcctggatg 2415901 caaagtagta ggcaaagaag gaaacagctg aattgacaag accgaatgta ccgagagcaa 2415961 gctcgctgtt tgtctcaata aatacaaaca cactgattaa aaagacaaaa atcccttctc 2416021 tcaaaccctg aaaaaaatgc gcattcgtga ttctccgcca attcatattg ctatggcgct 2416081 ctccaaatac tttgctcagc ataaaacggc cctttgattc tctccgtttt aagaaaaagc 2416141 tcatcacgac agccagggca aataaactga gggagagact gaaaatcact gtataacccg 2416201 tattattttc aagccttgag atcacgaatc cggctacaat cgggccgatc attcctgcag 2416261 aggaagacag aatgcccata aacccgttga aaaagtctcg tgtatccggc tctgttattt 2416321 caaaggtcag cacgttaaac gctagccaat aaaagccata gccaactccg agcaccgcgc 2416381 cgattagcac gaggcggctg gccgccgttt ctccggctaa aagcacactt aaataaaagg 2416441 cagctaaaaa aatgacgccg aaccttaaaa tgaataccct gtctattttt ttggctaacc 2416501 gtccagccaa ataaaaggtt atcggctgca ttgtcacaat ggataaatta tatatcgcca 2416561 aatcaataaa tttccctgac tgcttccaaa gatacacatt aacaaatgta ttggacagtg 2416621 caattcccag cgagtaaagc ccgccaatgg tcagcagaaa gagtaagcct ttgtttacgt 2416681 ctacatcgcc tatcactttt tttagtttgc tcattactga ctccccttta ctatccctta 2416741 gtctgtctca ctcaaaccga gatatgtaaa aagaagacat aaaaaaacaa ggtcccataa 2416801 tgaggacctt gtttgtgcca ttattttgct tcgctgtata gacgagccac ttcgtcccag 2416861 tttacaacat tccagaaagc tgaaatgtaa tcaggacggc ggttttgata gttaaggtag 2416921 taagcatgct cccaaacgtc aagacctaag ataggcgttt tgccttctga aagcggagaa 2416981 tcttggtttg gcgtgcttgt gatttcaagt ttaccgttgt tcacaacaag ccatgcccag 2417041 ccagaaccga agcgtccagc tgctgctgct gcgaattgct ctttgaattt gtcaaagctt 2417101 ccaaatacac tgttaatctc ttcagcaagc gcgccagtcg gttcgcctcc gccgtttgga 2417161 gataaaagtg tccagaataa tttgtggttc gcgtgtccgc cgccgttgtt gcggactgca 2417221 gtgcggatgt tttcaggaac agaatcaaga tctgcaacaa gctcttcaac tgatttgttg 2417281 gcaagagcag tgtttccttc aaccgctttg tttaaatttg tcacgtatgt gttgtggtgt 2417341 ttcgtatggt gaatagtcat agtttccttg tcgatatgcg gttctaaagc atcgtacgca 2417401 taaggtaatt ctggaagttc gtaagccatg ataattcctc cttagtatat atgtactgaa 2417461 atgccgcttc acagcgagcc tttcttcatt caatgtaaca aaagaatgct ttgtaatcaa 2417521 tgaaaaagct cacgatttgg ctcatttcag cggacatatt tcactttaac cgataatctg 2417581 ccccattaaa cctgccgcca gcatttctta taggaccgtc cataaaaagt aaccgatcat 2417641 caaaagctgt atgatgccct ttgcaataac ccctgttaaa aaaccaatga gtgagccgag 2417701 gccaatttta aacgctgact ttaagtcctt ctgatggacg ataagttctg cgcaaacagc 2417761 cccgataaac ggccccaata tgatccctgc aaccggaatg acaaaaggcc cgattaataa 2417821 accgatcgtg cttccccata tggcagcttt gcttcctccg aaccttttta ctccaagcag 2417881 attcgacacg taatctgctg cgaataatac tgcggcaaaa actgcctcaa caagccagaa 2417941 catataagaa tacggactga atgaaaataa aaatccgtac aatacaaatc cggcaacaat 2418001 aaatactacg ctaggaataa caggatacac cagcccgata aaggcaatga taaaaaccgc 2418061 tgcaatcaac agccaataca acatatccat agcttccatc ctcccatttt actctgtctt 2418121 cttcatgtct tccttgtatt cacacgcatg caacgataca ataagcaaca tatattagtt 2418181 tagctaggaa gtgaagatag tgaatgtgtt tcagcttttc attaaaagta catactctcc 2418241 ccgtgatatt gcaaaaacaa gatttcaagg aatcggaaaa gcgattcttt atgtattttt 2418301 gctctctgtc ctgtttgcaa tccctaccgc ttattatgta agtacaggga ccgtaaaatc 2418361 aatgaacggc tttaaaactg ttttaaacaa agatttccct gatttcacaa tttcaaacgg 2418421 caaacttcaa acggatgaga aaaaagccac ggaatctcag gcaaatggtt tcgttatcgt 2418481 gttcgatccg acagactcct atggcactga acaaattgaa gcaaagcaaa acgcaatcgg 2418541 catccttcag aacaaatttg ttttggccat tgacggacaa gcccaagaaa tgtcttactc 2418601 aatgatgccg tcagagttac agaaaaaaga tgtcattgca ggtttaaacc aaaataaagc 2418661 gatgattgta actgttctct cagctcttat ttttctcgta acagcagcgg gaaaatttat 2418721 tgaagtatcg tttttagcgc ttatcgggtt aatcattaag aattcgcaga aaaaacattt 2418781 atcctatcat cagctctgga agctttctgc ttattccatc acactttcaa ctgtattctt 2418841 tacaatcatg cgggcactag aagcaaccgt accaagtgaa tttttgctga actggtttgt 2418901 caattttgtc atcctgtttc tcgttttaaa agagattccg tccaaaaaag taattaataa 2418961 aagttaaatt atatttattt ttatccttta agtagagagt gtgaaagcat ttgcattaac 2419021 tttttactta agggatattt aataaaatgt atagagctta aacagataca tttataaaaa 2419081 aagctctaca attactcaag aacaagctct ggacaataat atcagaagta gtaagatgta 2419141 acatgaaaga agttcttaac agcatttgac atatgttttt aacaaaataa gaataatgtt 2419201 aaattttaac taatagacta gttaaaatca tatggcaaaa tattttgcat cctttcacaa 2419261 catatttaca taagatagtt gctatttaaa aagccaggta ccaatagggc acctagcttt 2419321 cagaattaaa tcatcaacaa gttagaatta tcttctttcc ttctattctc attattgaac 2419381 tgttatcttt tttgtgggtt tatgtataca aatgcagctc ccttagcttt ccccttatat 2419441 actgataaac ctactgccca aggtgttcct gtcggttttg gtaatttact gaagtaaaac 2419501 tttttggttg gagttctact tgaaaagtac cctgaatatt gcgggccaat gtccccaccc 2419561 tcaactatag atacaccaaa gctcttataa tttagtttac cgcattttcc atttgtttcg 2419621 gcgtaagcat caatagatgt tgcactctta gtatatgtat aagcatctgt aataactctt 2419681 attttacaac cagaaatacc acttaccggt tgccaaccac tgcttgcagc ctctgctttt 2419741 tctttaggtg caactaccaa agttaacatt agtagcaaaa ttaaaaacac agaaaatttt 2419801 ccttgcttca ttttgtagat cctcctttaa actattacat aattatccta acagatccat 2419861 tgttcattgt aaataatgga atacgagttt tatattataa aagcctcttt ttgatctaat 2419921 tttgcactat tttctatttt ctatctgaag ttaatgttta gtcgaagaaa tcctgtcaaa 2419981 aaagcgcctg tataaaaacc gagcattcgc agtctctttt cttttgtcat gaatcgaaat 2420041 ggacaagcat actatggtat aaaatttcgt atgcgggagg aaaagcgatg aagcgtctca 2420101 ccttagtatg cagcattgtt tttatacttt ttattctttt ttatgacctt aaaattggaa 2420161 ccatacccat tcaggacctc cctgtctatg aagcatcagc aaaaacggct gtacaagaac 2420221 cggcttataa aacggtgaag gtaaagccgg gtgatacggt tatgtcgata gtcggatcag 2420281 caggttctcc ggatgacatt gtaaaggatt ttgaagcact gaatccaaat gtgaaagcta 2420341 acgccattca agccggaaca gcgtataaat tcccggtcta cccttaattt aacgttaatt 2420401 tcttgtcagt tcggcgaaga cactgttaca atgtaatttg taaaataaat tcacataaac 2420461 catactagaa ttgttatatc tagaagcggc aactacaatt aaggagcgat tgcaagtgag 2420521 tgaaatcaca catcgtacaa aaacgcgtcc cgtcaaagtg ggacctttaa caataggcgg 2420581 caacaatgaa gttgtcatcc aaagcatgac aacaacaaaa acacatgatg tagaagcaac 2420641 ggttgcggaa attaaccgtt tggctgaagc cggatgccaa atcgttcggg tagcatgtcc 2420701 ggatgaacgg gcggcaaacg ccattgcgga tattaaaaag cgcatttcca ttcctctcgt 2420761 tgttgacata catttcgatt ataaacttgc gttgaaagcc attgaaggcg gcgcagataa 2420821 aatccgaatc aaccccggca atatcggccg gcgcgaaaaa gttgaagcgg ttgttaaagc 2420881 ggccaaagac aaaggcattc cgatcagaat cggagtaaac gccggttcat tggaaaaacg 2420941 gattttagaa aaatacggtt atccgactgc cgatggaatg gtagaaagcg cacttcatca 2421001 cattaaaatt cttgaggatc ttgattttca cgatattatt gtcagcatga aggcctctga 2421061 cgtgaacctt gcaatcgagg cttatgaaaa agcagcgaaa gcgtttgact acccgcttca 2421121 cctcgggatc accgagtcag gaacactgtt tgccggcaca gtaaagagcg cagcaggact 2421181 cggcgccatt ttaagcaaag gcatcgggaa caccatgcgc atttcactaa gcgcagaccc 2421241 tgtagaagag gtaaaagtag caagggagct tctgaaatct ttcggcttag cctccaatgc 2421301 tgccacgctc atctcatgcc cgacttgcgg ccgtattgag attgatctaa tcagcattgc 2421361 caatgaagtg gaagagtata tttctaagat aaaagcgccg attaaagttg ctgttctcgg 2421421 ctgcgctgta aacggacctg gtgaagcgag agaagctgat atcggaatcg ccggcgcacg 2421481 cggtgaaggg ctgctgttcc ggaaagggaa aattgtccgt aaggttccag aggaaacgat 2421541 ggtagaagaa ctcaaaaaag aaattgacat tcttgctgag gaacactacg caaaacttga 2421601 agctgaaaaa gcaaaattaa aagaagaaac acaaaaagct tgacgggaac ccgtcaagct 2421661 tttttgtgtt agaaaaatgg aataataaat attccaagca ctaatgaaac gacaccgata 2421721 cccattgccc aggctccaag gccttgagca cctcttcttc ttgcgatata gccgacaata 2421781 ataccagcag ctcccaataa aacaggcagt acaaacaatg aaatgatgga caaggctaaa 2421841 gcgatgtacc ctattccccg tccttcattg acattgccgc cgctgcgatc attgtcttgg 2421901 tcattgctgc ggtcagcagc acgataaggc tctgcgattt cagcagctgt ttcctcaaaa 2421961 aaaccgtcat tgtcgcgggt aatatttgtc ccttcagatc catgatcaac atagtaactg 2422021 ttgttatcac gcttttcgta atcgtttgcc accttcaatt cccccttctg ttttattaaa 2422081 ggagctttta tagtttgatc cattttgcct gattcatgtt tgctaaactt ttctgttaat 2422141 gtcaattgtt tatgttacac ttgaagggat gaaactgaag gagtgtgggc atgttacgct 2422201 taggaataga tattgacggc acaatcacgg ctcaggatac attcgtccct tatttgaacc 2422261 gttcgtttaa tctttccatt tcattaaacg atatgacgga ttatgattta acaaagctgt 2422321 taaacattac ccaggaagaa ttttgggatt ggatgaatca aaatgaagcg atcatatata 2422381 aggaagcatt gcttgcacag catgcgaaac agtctctcga tcttctcaaa gaggagcaca 2422441 agcttattta tattacagcg agacggactc atttaactga tattacttat gaatggtttg 2422501 acagacaaaa cattcattat gaccacatcg aacttgttgg gggtcatcac aaagttgaag 2422561 cggtcaagaa tcataacatc gacctgtttt ttgaggatca tcacgggaac gccatgatga 2422621 ttgcgaaaga agccgggata ccggtgattt tgttcaattc cccttataat cagcttccga 2422681 ttgattcaaa catcatcaga gtaaacaact ggctagaagc cgttcaatgg atgaacaaca 2422741 acaagcatca cttaatacgc gtcaataact gaaaaaggag cccaaaccgg gccccttttt 2422801 catatatacg cattttacgc agtagtgttt tcttggtttt ccgctgtaca atcagggcat 2422861 gtgccataaa tctcaaattt atgcccgctg acctgatagc catccaaatc atcacaaagc 2422921 ttgtccatcg gacatgattc aatttccttt gttttgccgc aggcaagaca aataaaatga 2422981 tggtggtgat gggtgaatga acacttaaat cggaagagct tttcaccgga cagctcagtt 2423041 gtttccaaaa tcccaagttc ttcatataaa gaaagatttc tgtagattgt atcaaagctt 2423101 aagcctggat aatcatcatt cagtgcagac agtacgtttt tagcggtaag atatctgtct 2423161 gaatcagcaa aaagctgcag catatcctcc cgtttgtttg tatatttata tccgttttct 2423221 tttaataggt tcagcgcttc ttggacgttc atgaagggtc ccccttttcg ctttgcttaa 2423281 gaacgtatca catgtatgaa aaagaaaatg gcagctgtct gtccagcaag ccattttctt 2423341 tactgcagat aaaattatac ccataaaatg aataaaagta aatgaaagcc tagtggattg 2423401 cgtttttgaa ttttccgcct ctcgtttcat gagtattcat aattgttatg aatgcatttt 2423461 gatcaacttc aaacacgatc gatttgagct ttgtcacttc cagccttgtg acaaccgcgt 2423521 aaattacgtc tttttcttcg tccgtatacc cgcctttccc cttcagcttc gttgtgcccc 2423581 gaccgagacg gtgcaaaatc gcgtcggaaa tctcatcata ctgctcagac acaataatga 2423641 cagcttttgt ttcatcaagc ccttggatca cggcatcaat cgttttcatc gcaatataat 2423701 aagtcatgaa tgagtacatc gcttgctcag gaccgaacac aaaaactgcc caaatgaaaa 2423761 tgaacacatt gatgaacata acgaactcac ctacagaaaa cgggagtttt ttggtcagca 2423821 aaataccgag aatttctgta ccatccattg aacctccatt tcgaataaca agcccgacgc 2423881 caaagccgag taaaagacct ccgaacacag tagccaaaat aggctgggtt gtaatggctt 2423941 ctacatggtg aagtgaggat tcaataacgg caagcccgac aatccctata aacgtagaga 2424001 ctagaaaggt cttaccgata tatttatatc cgaagatcat aaaaggaata tttaatatga 2424061 caacgaaaaa agcgaaattc agaaaggggt ttgacataaa gaggtggtct aaaataagag 2424121 atacaccgat aatcccgcca tcaataaaat cattggggat taaaaataat tcaatactta 2424181 cagccgcaga tgcagctcct accagaatca taaagaccct gaaaataaaa tgggtaaatg 2424241 tttctttctt atgttgtttt gttggggtca taaaatctcc tttcctgcaa taactatttt 2424301 aaatacatta taaatctatt ttaccattaa acactgacac attttactga tttgcccata 2424361 cattaagtct ggaggtggaa tgaccgatga ttttatttca aagaattatt ttgcagcggc 2424421 ttaatcaggc tactgctgat gatttgctga agtactcaaa acaatacgga atcagcttaa 2424481 caagatcgca ggccgttgaa gtagcgaacc tgttatacgg gaaaaatgta aacatcttta 2424541 atgagagtga acgaatgcgg ctgctgaaac aagtagagac gattacatcg aaagaaacag 2424601 ctcaaacagt taatgaacta ttcaaacaat ttacaagcta aaaaatgggg gtgttatccc 2424661 ccatttttta ttgctgtaaa atcttttcaa gcaatgtatc atcaaattgt ttttctttca 2424721 gcatttcaat ctcaaaacgg tatggcggtt ttttgttctt tttatcttca ccgacgtatg 2424781 gtgtttcaag aatttttgga atgtctttta actgctcatg gtgaacaaca tattgcagtg 2424841 cgtcaaaacc tatttcacca aagccaatat tttcatggcg gtcttttctc gcacctttga 2424901 catttttgct gtcattgata tgaagcactt taatacggtc aatgccaatg attttatcga 2424961 actcatttag cactccgtca aagtcttcga caatgttata cccggcatca tgtgtatggc 2425021 acgtgtcaaa gcacactgac agctgctcat tgtgtgtaac gccttcgata atctgcgcaa 2425081 gctcctcaaa gcttctgccg cattctgatc cttttccagc cattgtttct aatgcaatct 2425141 ggacattttg attcggatca atcacttcat ttaagccttc aataattttt ttgatgccgg 2425201 cttcagctcc tgcccctacg tgagcgccag gatgaaggac aatttgcttc gctccgatgg 2425261 ccgctgtccg ttcaatttct gaacgaagaa aatcaacacc cagctcaaaa gtggacggat 2425321 ttgtcgtgtt gccaatatta ataatataag gcgcgtgtac gataatctcg tcaatgccgt 2425381 tttcttgcat atgtgcccgg cctgcttcta tatttaagtc ttcaattttc tttcggcgcg 2425441 tattttgcgg tgcgcctgta tagatcataa acgtattcgc cccataagag actgcttcct 2425501 ggcttgcagc cagaagcata tgttttccgc tcatagagac gtgtgagcct attctcagca 2425561 acaggttccc ctactttctt ttcttagatt ggtttcttct ctgttttttc ttgattttct 2425621 ccatctcata gctcattttc tttttatacc caggcttaac cttcttcggc tttttcacga 2425681 gacgatgagc aatttcatcc gcttcattcg gcgttttttt acgttttttg cggcgctgac 2425741 ggtcatcgcc ttttttccat tcgccctttt caagctctaa gtactcaaat tcgatgccca 2425801 ttttttcaag tcttactaat gcatcctcat cagtaagctc ataaatggtc atcgcttgtc 2425861 ctgatgagcc ggcacgagcc gttctgccca cacggtgaac atagaaatcg agatcatccg 2425921 gcagctcata gttgataaca tggctgacac ctttaatatc aatacctctt gcggcaaggt 2425981 cagttgcaat gatatatgtg aattccaaat cattgatctg cttcatgact tttttccgct 2426041 cacgtggtgt taatccgccg tgcagcaagc cgattttcat gcctttgcca gtcagatact 2426101 gggcaatatg gtcagccgta tttttcgtgt tggcaaacac aatccccagg tatggattca 2426161 gatgcgacat gatgtcaaaa aggagcttgt ccttgtcacg atgtttcgaa ggaatgagga 2426221 tatgctcgat tttcgcagca gtcacctgtt ttggctccac atgggcgtat ttcggatttt 2426281 ccatgtattt cttcaagaat ggtttcagct tttccggtat ggtcgctgag aacacaagca 2426341 tttgcagatc ctcaggcatg cgggaaccga tgtaatctac atctgcaagg aatcccatgt 2426401 ccagcattaa atccgcttca tcaataacaa gagattccgc tttatgaaca cttaacgcct 2426461 gttctttgat taagtcagca atccgtccag gtgtaccgac aacaagatgc ggctgtattt 2426521 tcaatttatc aattgatttt tgtttatcag tgcctccgat aaaacatttc gagcgaatct 2426581 gacttccttc ttcaccctgc gtgattttaa gcgcttcctg ataaatctgg ttggcaagct 2426641 ctcttgtcgg agccgtaatg actacctgaa cgacatcctt agcaggatcg attttgttta 2426701 ataaaggcag taaataagcg tgagtctttc cagtacccgt ctgagactgg ccgatgacgc 2426761 tttctttttt taacactgca ggaatcagcc ttttctggat atcagtcggt tcgtaaaaac 2426821 caaggcgatg tactgcatct ataataaatg gtttcaattc ataaagttca aatttcgttt 2426881 ctttcatttt tcccagctcc ttaaagcggc acattatgtg tccatcatca cattataccc 2426941 gattttgctt aaaaacacca cgtttgcaag gcgtttgttt tattcagtta tgtaaagcaa 2427001 ataccgcagc ccatgcatat tctaatagca gagagagctg aaaggaggta caagtatgtt 2427061 ttcaccgcag cagccaatga gaaattaccc acagcccgga ccgccccgcc ccatgccaaa 2427121 tcagcgaatg atgggcagaa gaccgcctaa tatgcgagga ccttcatttg gagcacagca 2427181 gcaaggtttt cagcaagccg gacaatttct tcctcaggca aatgccggag cgagaaatgg 2427241 tgcaggtgca ggcggaggct taaaaggaat gctgtcaagg ttcctccccg gcggaggagg 2427301 cgctggcagc gccggggttc ccggaattcc aggagcaggt gcagcagcga gcggaggtgc 2427361 tggcctgcaa ggcattcaaa atattgccaa tcctgcatca ttatccagta tgcttggaaa 2427421 tgtgcaaaaa gtactcggca tggcgcagca agtcacccct atgatccagc agtacggccc 2427481 attagtccgc aatctgccag caatgatgaa gctgtacagc caattaagta aaagtgatga 2427541 tactgagaca gaggccaatg aggaaagtga aaaacaatcc gtttcagaag aatcatcaga 2427601 aaaagaaaaa gagactgaaa caaaaacctc agatgggaac aaaaaatcaa aaccaaaaag 2427661 ttcttctctc ccaaagaaat ctaaaacaac tgacaataaa gaacaagaat taaaaacatc 2427721 tgccccgaag aaaaaggaag ctgcctctcc tgctccgaaa agaacatcag gcagttcaaa 2427781 accgagatta tatatttaac attctttgat atcttaagtg agattggcta taatgagatc 2427841 agaagaatgc aagaatagag ccgtttgatt acggcttttt atattgcctt tactcacttc 2427901 agtattggag gacaaccgaa aatggacgta attaaaattt caccgcgcgg ctattgctat 2427961 ggtgttgttg atgctatggt cattgccaaa aatgcgtcgc tagataaaag cttgccaaga 2428021 cccatctata tactcgggat gattgttcat aataaacacg tcactgatgc gtttgaagag 2428081 gaagggattt ttacattgga cggctctaac cgtctggaca tcttaaagca ggttgacaaa 2428141 ggaactgtca ttttcactgc gcacggtgtt tctcccgaag tcagaagaat cgcagaagaa 2428201 aaagggttag tcgcaattga tgctacatgt ccggatgtga caaaaactca taatctaatc 2428261 ttagagatga aagaaaaagg atatcacgtg atctatatcg gcaaaaaagg gcatccagag 2428321 cctgagggag ccgttggcgt agcgccggag atcgttcact tagttgaaac agaagaagat 2428381 gtaaagaacc ttgatatcca atctgagaag ttaatcgtga cgaatcaaac aacaatgtct 2428441 caatgggatg ttcacgacat tatggagctt gtcaaagaaa aatatcctca tgtcgaatat 2428501 caccaagaga tttgcctcgc tactcaagtg cggcaggaag ctgtatcaga gcaggcaaaa 2428561 aaagcggact taacaatcgt tgtcggagac ccgaaaagca acaattcaaa taggcttgct 2428621 caagtgtcag aggaaatagc cgggacaaaa gcataccgga tcggcgactt aagcgaattg 2428681 aagctcgaat ggctgaaagg cgttaatacc gttgcagtta cagcgggagc ttcaacaccg 2428741 acgccgatca caaaagaagt cattcgcttt ttagagcagt ttgatcacga agatccatca 2428801 acttggacaa ctgaacataa tataccgctc aaaaaaatac ttccaaaagt aaaagcaaaa 2428861 aactgaggct gtaaaagcct cagttttttt atagaaatgt aaatggattt gtatctgttt 2428921 cagaaacaaa gatattcacg ccaaactttt tatcattaca cattgatgta agttttctcg 2428981 tgacgccttc tttcatgatt ttttccgcgt aatggcccgg atcaaccaca tttaggccaa 2429041 gcatcatcgc atcatgggcc acatggaagt ataaatctcc tgtgacgtaa acatcggctc 2429101 cctttcgttt tgcatgatga atatacttgt ttccatctcc gccaagaaca gctacttttt 2429161 tcaccatgct gtcagcatcc ccaaccattc tgacaccatt gacgtcaagc ttgtctttca 2429221 caaataaagc gaattccttg agcgtcatct catttttaag ggttccgaca cggccgagcc 2429281 ctttttcggc gggagtctgt tcgacaggat agatatcgta agcgacttct tcatatggat 2429341 ggctttttat cattgcattg ataacagcct tttcgacgct tttaggaaat acagtctcaa 2429401 gccttacttc atgaacaagc tcaagctctc ccacttcacc gataaaaggc ttagctccgt 2429461 ccaatggctt aaagctgccg attccttcag atgaaaacgc gcaatggctg tattcaccga 2429521 tatggccggc ccccgcattt ccgagcgcgg ctctgacctg ctcttcatat tccttcggca 2429581 cgtaaactgc cagctttttc agaggatccg tataagtagg tgccagcact tccgtctcac 2429641 tcagctctaa tgcttcagca agcaaatcat tcacaccgcc gtccgcaacg tctaaatttg 2429701 tatgagctgc ataaacagca atatcatgct tcaaacactt ttcaattaac cttccggcag 2429761 gctgatctgt tgaaatatgc tttagcgacc ggaaaattgg tggatggtgt gcaataatca 2429821 agtcaacctc tttttcaatc gcttcatcga taacgctctc taacacatca agtgtaacca 2429881 tcacattttt aattggtttg tttaaggtgc cgatttgcag gccgatttta tctccttcaa 2429941 ccgcataggc tttcggggaa aattgttcaa acagctggat gatctgctgc ccatttacac 2430001 ttttagccat gatcgattac ctcctttaac agctccattc gatcggcgag ctcctttaat 2430061 ttttgtttgt tttgctctgt atccgccgct tggctgatct gttcataaat gctttgagtg 2430121 tgctgaagct cttgtgtcca ctttttcaaa aagacagcat ttttttcttt tgccaagaaa 2430181 gggccaacga gcatcccggc tgataaagaa ataccgtcat aagccgcatc cctgtctccc 2430241 gcttctgcca ccagcacctc atagcacttt ccgtcctctt caaggattac ctcatctatc 2430301 agcgcatatc tttctttata aagccactcc ctgatatgaa cagcatgaat attcggctgt 2430361 aaaatgagcc gttccttccc cgttaatttg tctttgcccg cttctaaaat gtgagcgatc 2430421 aaagccccgc ccattccggc aatcgtaatg gcatcagctt cacctttttt aatcacttcc 2430481 agtccgtctc cctgccttac agaaatgtgc gagtttaagc ctgatttttc aacctgccgc 2430541 tttgcagaca aaaatgggcc gtctgttatt tctccggcaa tcgccccgct ggctttatga 2430601 ttcagcaccg cataacaagg aaggtaggcg tggtcagagc cgatatcggc catcaccgct 2430661 ccattcggta tgtactccgc tactgtttgc aatcgtttag ataattttaa ttcgttcact 2430721 tgtcatcaca acttttctca atcatttttt cctttactat catataaaaa atcagcccgg 2430781 aatccaagct gaagcaaatg attttgaaat tatttctttt gatgcgggtc tgcacgcagc 2430841 agtcaaaaat aaaaggctgt cgagaacatc tcggcggcct gtgaatgtat aaagagaaaa 2430901 atagttcttt tatttaattt ttgacaccca ctctgccata tcatccagct tatcggccgg 2430961 aacaagaccg gaaggcattc cattaccgcc tttttcgatc tttgttttaa tttcagcgac 2431021 atctttctta tcccctacac cttttaagct aggacccgaa acaccttcat aattttcacc 2431081 gtggcatgcg atgcagtttg ccttgtaaat ttcttctggt gaagcgtttg catctttctt 2431141 ttcagcagat ttgctttctc ctccgctcgc aatctcccga gagtcatcaa gtccttttac 2431201 tgataaaaag aaagttagac caattcctaa aacagcgatc agcaaaaatg gaataagcgg 2431261 gttccatttc atttcccttc cccctttttg atccttcccc ctatgtaaac acttctaatt 2431321 ctaacttatt tttacaaaaa gtaaatggat tgctatacaa aagtttttta ttcacacttt 2431381 atacaaaatt gaatagaaac atgcctaaat ctctaatatc ctttttattc tattgtataa 2431441 tgtattgtat acgcttacaa tagaaaatat ggaattagat tttgaaattt ttcaccacaa 2431501 tgttcatttg caaatgacat catttttcag taaaataaag gcatattatc catatatctt 2431561 tttaaaaaaa gaagaacgga tcttcaagac ccgttccatc ttattcaagg aaatctttca 2431621 aacgtttact tctgctagga tgtcttagtt tccgcaacgc tttggcttcg atttgtcgaa 2431681 tacgctctct cgttactcca aatactttgc cgacctcttc taatgttctt gtacggccgt 2431741 catcaagacc gaatcgaaga cgcaatacat tttcttcacg atcagttaac gtatcaagca 2431801 catcttccag ctgctctttc aatagctcgt atgcggcgtg gtcagaaggt gaagttgctt 2431861 cttggtcttc aatgaaatca ccaaggtgcg agtcatcctc ttcaccgatc ggtgtttcca 2431921 gagataccgg ctcttgagca atctttaaga tttcgcgtac tttttcaggc gttaaatcca 2431981 tatcttccgc aatttcttca ggtgttggtt ctctgcctaa gtcttgcagt aattgacgct 2432041 gcacacggat taatttatta atggtttcaa ccatatgaac gggaatccgg atcgttctcg 2432101 cctgatcggc aatggcgcgt gtaatcgcct gtctgatcca ccacgtagca tacgtactga 2432161 atttataacc tttgcgataa tcaaattttt caacggcttt catcaggccc atgtttcctt 2432221 cctggatcag atcaaggaac agcataccgc gtccgacata ccgttttgcg atactgacaa 2432281 caagccgcag gttcgcttca gccaatctgc gtttagattc ttcgtcacct tcttcaatct 2432341 tttgagcgta ggcgatttct tcttttgcag aaagaaggtt aacccgaccg atttccttta 2432401 aatacatacg aactgggtca ttgattttaa cgccaggcgg tacacttagg tcattaaggt 2432461 caaattcttc ttcggctttg gcaagctgct gaatattagg atcttctgtt tcttcattct 2432521 cactaattaa ttcaacacct tgttcaccta aaaattcata atactcatcc atttggtctg 2432581 attcaatttc aaagctggac atacgctcag caatttcttc atatgtcaaa acgccacgtt 2432641 ttttaccaga ctctgttaat tgctctttta cttggtcgaa tgttaattct gtctcgtggg 2432701 tttgtttatc agccattatg gatccctcct tccaaagctt gcaacgaatt ctataagcgg 2432761 tatgattctt attcggtcca ttcaggcgtt ttctatgtga actgccttta acaatgtgcg 2432821 aataatgaaa tgacaattca tgatgaggtt aagcgatcta tttgctcctc cgcaaggaat 2432881 cattgccaat aaatgctcct catcagttct ccagttattt taaagatcgg ttcaatgtaa 2432941 cgatttcttg agccaaagaa gcagctctta aaaaatcttt ttgcctttct gcttcggctc 2433001 tttccgcctc tttttctttt atcattgacc aatttctttg attcaacact ttttttacat 2433061 aatctgataa ctcggcttcg ctaagctctt gattaacctg aagcattaat atatcggaca 2433121 agagctggct tatatgatca tccgtcaccc tggccatcag atgctgaggc gtcagctcgg 2433181 ctccctcttc ataaaaagca taaagataag cggctaatgc ccggtgctca tcaatattaa 2433241 attgaaaccc tacccggtca atcacttttt tgatgacgct ccgatctcga agcatgtgag 2433301 cgagtaacag cctttctgca ttttcatacg ccggacgcaa acgtttttgc cttgcttttg 2433361 tcgtcagatg cgctcgccgc gttttagttt caccgctatt gtcagcaggt ttgttttgct 2433421 tgctgaaaac agacagctgc tcagttaaag actcctgtga aagcgaaaac tctgaagcaa 2433481 gctgctttac atagacttcc tgctctagag accctgaaag cgtgctgatt tctttcagta 2433541 cgtctttaat gtaagctagg cggtcgcctt catcggacag gttctttcct tttcggaaat 2433601 attgcatttt gaacgccatt acggtgacac ttgcgtcaat aatgtcgttt ttaaattttt 2433661 ccccgccgaa ttttttgatg taatcatcag ggtccaatcc gtcaggaatc attgcaactc 2433721 tgactttgca gccttttttt tgcagaagct ccgaagcttt taaggtggct tcataaccgg 2433781 ctttatcaga gtcatagcaa agaatgattt cttcgacgtt tcttctcagg atcttgacat 2433841 gatcatctgt aagagacgtt cccatcgtgg ctatgctttc ctttacatcc gagcttacgg 2433901 ccgatatgac atcagcaaac ccttcaaata agactgctct ttcctgcttt ctgatatgaa 2433961 ggcgggcctt ataaaaattg taaagcagtt tgcttttatg aaagagcggg gtttcaggac 2434021 tgttcatata cttaggctgc tggctgccaa gagccctgcc tgagaaagca acaacagccc 2434081 cgtgatgatc atggatcgga aacatgacac ggtttctgaa gcggtcgaaa tatccgcttc 2434141 cgtcttcgcg tctgatcagg agacccgctt tttccatttg cgcctcacta aatcccctct 2434201 ttacaaggaa tttcgtgata aagtcccaag aatcaagagc atagccaatc tgaaattcat 2434261 taatcagctc tttcgtaaag cccctagaaa gcagataatc cagtgcctct tgaccttctt 2434321 ttgtatttat taacaaatga tggtaaaatt tcttcaggag ctcatgtgcc tcagccattt 2434381 tttgttctcc agaagactct ggccgggctc cggaatggac tgttatatca tctggaaaat 2434441 caatttggta tttgtcagca aggtgagaaa ccgactcggc aaaagaatag ccttccatct 2434501 gccttaaaaa agagaaaaca ttgccgcccg ctccgcagcc aaagcaatga aaaatctgtt 2434561 tgtcgggcga tacggaaaac gaaggtgtgc tttctccatg aaaaggacag agtccaaagt 2434621 agtttcggcc ttgcttcttt aattgaacat aatcacctat gacttcaacg atatctgccg 2434681 acttttgcac ctgatccaca atttcatctg gtatccgatt tcccatctta taacactccg 2434741 tcgtacatta ttcgatgctt tagtgcaaaa tcccttcatc gttcgacagg attttttgca 2434801 gcagtgtaat aaatcgttct cgatcttctt tattcaattt tttaggccct ttggcatata 2434861 cgccttttct tctttgtttg ccggaaaaat gacggccctc tagggcaaaa tcaatcgtgt 2434921 cttccttgta aagacgacct ctttccgaca taacagagac atttctgttc aacagcagag 2434981 atgctaatcc gatgtcctgc gtcacaacaa tatctcccgg tttcacgtga tttgcgatat 2435041 ataaatcagc agcttcttta tgaggatcaa catacttcca tttttcttca ttgcttctgg 2435101 aaagctgata atgttcaaat gaagcgacaa aaagaacttg aacttcatac tcggatgctg 2435161 tttgtaaaat ttcatctttt accggacaag catcagcatc gacaaaaatc gtcttttctt 2435221 gttcattaag aagagtaatt ctccatccct ccattaaact cctgcataaa agcaagcaaa 2435281 atcgcacatc ctttattatt gtggatgtat atgaatttgt cgaaaaattt ccgggagaaa 2435341 ttcttgacat cttacccata atagtttatt cgtatcacac gatccttaaa cctaaaatta 2435401 atcattttat cacaattttt tattataata caaacttcac aaagatgcta ttgtttttca 2435461 ttattccctt ttggcacagc caaaaaccca ggatagagcg tcctgagtta tatgtttttt 2435521 gttttgagat gatggataat atttgctgtt tcctcaaccg ctttatttga aacatcaaca 2435581 acctggcagc cgatccgatc cacaatcttt tcgaaatact cgagttcctc tttgattctg 2435641 ttgatatttg cataaatcgc tttatcatta agcccgagtg attttaaacg ttcttttctg 2435701 atatgattca gtttatcagg gctaatcttt aaaccgatgc attttttcgg atcaacgtta 2435761 aagagttctt ccggcggatc aacctccggt acaatcggaa cattggcaac cttcaggcgt 2435821 ttgtgtgcga gatattgaga cagcggtgtt ttagacgttc ttgacacgcc gatcaaaacg 2435881 atatcagctt ttaaaatccc tcttggatca cgtccatcat cgtatttaac tgcaaactcg 2435941 atggcctcca cttttttgaa ataatcttca tcaagctggc gcacccgccc cggttcgtat 2436001 ttcgctgtta aaccgtaggc tgtttccatt ttatcaatca acgggccgat aatatcataa 2436061 tataaaacat ttgctttttc cgcttcggct atcaaatatt ctctgatttc cggcaccacg 2436121 agtgtaaaac agataatgcc gccgtctgcc tttgcaagtg aaatcacttc attgatagtg 2436181 cctatatctt caacataagg aattcttctt acatgagtat catccgccga tccgttaaat 2436241 tggctgagtg ctgcttttac taccaattca gccgtttcac cgacggaatc cgatacaaca 2436301 tagatgatgc ggttattcat attatccccc cgttagtttg caatcttata ggatttcatt 2436361 ttcagataaa ctgacaagta ttttggtcat atttgttttt gtcactctgc cgatcacttc 2436421 aaagccttta tcggtgtctt tgatgacagg cagtgcatca atttgttttt ctattaagtg 2436481 ctttgcaatg tccatcacat aatcctcgcg tctgcacacc gtaatgttcg gcatccttgt 2436541 catgatgatg tgaacaggga ccgatgtaag ctcctgctgg ccaatgctcg ctctgagcaa 2436601 gtcttttcgt gaaagcaccc cgactaaaac agcatcgcgg tccaccacaa acagagtacc 2436661 tacatcttct aaaaacatgg tgcaaatcgc atcgtacaca gaaacgtttt cgtgaatcac 2436721 tacggggata gattgaaagt ctttcacctg aagctttttg agtttatccg ccaaaagctg 2436781 tgtgccggtt tttcccgtat agaaataacc gactctcggg cgcgcctcga ggaatcctga 2436841 catggtgagt atggctaaat ccgggcgcaa tgtcgccctg gttaggttca gcttttctgc 2436901 aatatgctcc cctgtaatcg gcccgttttc ttttacaatc tgcaaaatat gttcttgccg 2436961 tttatttagt tcgatcgtac tcaccacctt ttcacttcat agctatgtaa agaaataaca 2437021 atccatatta taacgtaaat atcttgtaat caaacaaaaa acttataaat ggggaaaaga 2437081 cgattaccga tcacacagca accgcctttt ctctctttat tttacaataa gggcattcat 2437141 attcgcaaag gacttgatct catccgccaa gcttaccatt tgcgctaaac gatttgcctt 2437201 taatgactca ttatccgcta taaccattgt atgatcgaag taagcatcga tcggttcttt 2437261 taaggctgca agtgaagcaa gcgccgcctc ataatctttt ttgctgaagt tttcctgcag 2437321 attttgcttc gctgtttggt aggcatcaaa cagttttgct tcgtattcat tttcaaacag 2437381 atcaggctga atgtctccgc ggactccttt tttgctgata gagatcactc ggcctaacgc 2437441 ttcggctgtt tccttaaagc caggtgcacc aagcttttgc tccagtactt gtgctttatg 2437501 cagcgcagag tacggctcaa gctcagagct ttccagcacg gcgtcaatga catcatgtct 2437561 gatttgttca gcattcaaga catatttcaa gcgctgagtg aagaaatcca gcagttcatt 2437621 ttctttatcg gtttgaacga aagtaagcag ctcttcaaat gaaattcccc agttgcggtc 2437681 aagaagaatc gcaacaatac cgcttgcttg gcggcgcagt ccgtaagggt cctgggaacc 2437741 ggtcggaatt acgccgatag agaagaatga agcgattgtg tcaagcttat ccgccattgc 2437801 tacaacagct ccggtgaaag tagaaggcgt ttctccgccc gctgatctag gcatataatg 2437861 ttcattaact gccgcagcca cagcttcatc ttcgccaagc attctcgcat acttttcgcc 2437921 cataattcct tgaagttcag ggaattcata tatcatatgc gtcacaaggt cgaatttaga 2437981 aatttcagca gcccgcttca catgttttaa tgtatcttca tcagcctgaa gacgaacggc 2438041 aagtttctct gcgattgatg tgactctcct aaccttatca gcaagagaac caagctcttc 2438101 atggaaaacg atattttcaa gcttcttcac atttgcatca atgtttagtt tctgatcttc 2438161 tttgtagaag aatgaagcat cagataaacg tgcgcgcagc actttttcat tgcctcgggc 2438221 cacattttca atcgcgtggc tgttgccgtt tcggactgtg ataaagtgag gcagcaggtc 2438281 accgtttttg tctttgacag ggaagtagcg ctgatgctct ttcattgtcg tgacaagcac 2438341 ttcttcagga attgacagaa actcggattc aaatgaaccg taaagagctg tcgggtattc 2438401 tactaaatga ttcacttcat caagaaggtc ttcgtcaact ggaatgctcc aattgttttc 2438461 agcagccatt gtttccagct gagattgaat catttgcttt cggacgctag gatcagcaat 2438521 aacatgctgt cctttgagct gctcttcata agctgaaggt gattcaattg acacttcatg 2438581 tccgaggaaa cggtgtccct gtgttgtccg tccagactca acgtttgtga tcgaaaatgg 2438641 aatgacatcc tgtccaaata atgcgacaat ccatttgatc ggtcggatat aacgcaaatc 2438701 ttcatttccc cagcgcatgt ttttcgggaa atgcaagctt gtaattaaac cgctcaattc 2438761 tggcagaagc gacttcgttt cttggccggc ttggaatttt tgcacgaata catactctat 2438821 gccttttact tctttgatgt acaggtcttc cacatttgcg ccttggcctt ttgaaaagcc 2438881 gattgccgct tttgtccagt tcccgtccgc atcaagggca atttttttcg caggcccttt 2438941 tgcttcttct tttatatcat cctgcttttc tgcgacatcc ttaacgaaca cagcaagacg 2439001 tctcggtgta ttgaagagtt tcacttcacc gtgagtaata tttttttctt taagccagcc 2439061 tgtcagcttg tcgccaagct gaaccatgct ttcattcaaa aagcgcgccg gcatttcctc 2439121 taatccgatc tctaaaagta aatcctgttt actcatgaga agaaccctcc cctttaagca 2439181 ttgggaaccc tagtttttct cgttcctcat agtaggtttt tgctactttt ctagctaaat 2439241 tccgcactct tgcgatatag cccgtccgct cggtaacaga gatcgcacct ttggcatcaa 2439301 gcaggttgaa agtgtgcgag catttcagca catagtcata tgctggatga acaagtccgt 2439361 tgtccatttg cttgatcgct tctttttcat atgtgctgaa caattggaac agcatatcga 2439421 cgtctgatgt ttcaaacgta taaacagaat gctcatattc agccatcatg aataaatctt 2439481 ttactgtaaa ccctgacgtc cattccaagt caaacacgtt ttctttatcc tggatataag 2439541 acgcgagacg ctcaattcca tacgtaatct ctacagaaac gggtttacac tctaatcccc 2439601 cgacctgctg gaaatacgta aattgtgtta tttccattcc gtcaagccaa acttcccagc 2439661 ctagacccgc gcagcctaaa gacggattct cccagttgtc ttcaacaaag cgaatatcgt 2439721 gctcaagcgg atcaattcca agagcacgca aggaatccaa atacagctct tgaatgttat 2439781 caggtgacgg tttaataatg acctggaact gatgatgctg atacagtctg ttcgggttct 2439841 ccccgtagcg gccgtctgcc ggacgtctgg aaggctctac ataagccact ttccacggct 2439901 caggaccgat actgcgcaaa aatgtatacg ggctcatcgt gccggctcct ttttctacat 2439961 cgtaagcctg cataagcaca cagccctgac tggaccaatg cttttgcaag gttagaatca 2440021 tgtcttgaat attcatttca agcacctcca cttttctttc ataagttgac tgcggcagca 2440081 accaaaaaac tcccgtctct atgcttgcca gccgcaaaca tagggacgag agttctcccg 2440141 cggttccacc ctagttgctg agaacaaaat cccagcctct tttttaaaat tgctcaagaa 2440201 tgcctttcgt tgcgtgctca tccttagctt acaccgccct aaggtcgctt tcatgaggta 2440261 aacgcaagta cttctttctc tcactgcaac atattttata ataaatgatc atataaaaag 2440321 atggaccaaa tgtcaacttt tgttttcacc cataagatgt ttcatgcttt ccatttgatc 2440381 taaaaagcgc tttgatttta aatacaatcc cgaatattct tcgtaatata aatcaatcac 2440441 ttgctttaat tcagcttttg tttcctcttt taaggacaca ttgccgagtc tcgacagatc 2440501 aaaatagtaa aagagcctta acagccttgc cgtttgcggt ttaatcggta tcctgtaagg 2440561 atctttttca aaacagcggt ggcatataaa accattatca cgaacagaga aatgaaaggt 2440621 tccgtcttgg cttttacaat gtacacaatg attcagctca ggatacaggc ccatgacacc 2440681 gagcatcttc atttgaacaa tgaaggtgat aacatccgga tctgttcctt cattcaactg 2440741 ttttaatgat tctaatatga attcaaataa ataaggattt ggcttttttt cttctgtgcc 2440801 tctgtcgact aactcagcaa cataggcagc atatgctgtt aaaaacaagt cttccctgat 2440861 gcctctcatg ctgaggatca tttccccctg ctgaagcgtt ccgaggcccg atgttttttg 2440921 cattaagaaa gaaccataca aaaagggctg gctgactgct gataaacggc tgttcggttt 2440981 tttggcgcct cgtgccataa cacctatttt tccgtgttct cttgtcagta atgttacgat 2441041 tttattcgtc tctccgtaat catttgtgcg aagaacgatc ccttcacatt ttgtcagcat 2441101 ttccgcacct tcctcaagca ggagcggcca agaggtttat aaaattggat aatcaaatcg 2441161 ggctagctca tcttctagtt cttcgggtct ttccatgttc tctttttcca gttctttaaa 2441221 aagaagatac gtatcaacat ttcctgtttg agaaaatacg ttccaggtaa aattcaacac 2441281 aagaaaccca cctttctgta gttaaactag cttacctaaa ctccaaattc ttacctttat 2441341 cttgaccaga tgtcctccat ttcatgttaa acaaaatttg ctaatgtatc cctgttcctg 2441401 tgagataatg acacacacgg gaagagatta atattcgtcc tctttaaagc caaaatcgcg 2441461 aagctgggac attttattac gccagtcttt ctgcactttc acccacaatt caaggtagac 2441521 acgggagccc aacagtgctt caatatccgc tctcgctctt tttccaacct cttttagaag 2441581 gcttcctttt ttaccgatca cgatgccttt ctgggaatcc cgctcgacca caatcgttgc 2441641 cgctacgtgc acagaaccgt tgtcctgccc tttgatggat tcgatggcca ccgcaatgct 2441701 gtgcgggatt tcttctctcg tcaaatgcag caccttttcc ctgattaatt cagaaatgat 2441761 aaatcgttca gggtggtcag ttacctggtc actcggatag aattgcggcc cttccggcaa 2441821 atacgcttcg atctgcgcga gcaaggtttc gatgttattt ccttctaaag cagaaatcgg 2441881 aacaatttcc ttaaaaggat aacgtttgcg gtattcgtca attagcagaa gcaattggtc 2441941 gggatgaatt ttatcaattt tgtttacgat taagaataca ggcgtagaca tcgtctgcaa 2442001 tttctcaatg atgaattcgt cgcccttccc gtagccttcc tcagcattga tcataaacaa 2442061 gatcaaatcg acttctttta atgtattttg cgccactttc atcataaagt ccccaagttt 2442121 atgcttaggt ttatgaatcc ctggtgtgtc aataaaaatg gtttgtgatg tgcctgtcgt 2442181 cagtactcct tgcaccttgt ttctcgtcgt ttggggctta tcgctcatga tcgcgatttt 2442241 ttgtccaatg actctgttca aaaatgtaga ttttcctacg tttggtcttc caataatgga 2442301 tacaaatcct gatttaaagc tttcgttcgt catgtaaatc ctccgatgaa aatgcgcctg 2442361 gcaataattc ttccacagtc atttctttta tttgtccttg taaattagtc agtacgacaa 2442421 taacgtcttt tgtgcaaagc tcagaaatca cctgtcggca ggctccgcac ggagatactg 2442481 gtccaggggt gtcagccgca acggccagca tctgaaactc tgtatcccct tcagaaacag 2442541 ctttaaataa agcggtacgc tcggcgcaat tgcacatgct gtatgccgcg ttctcaatat 2442601 tgcagcctct gtacactttt ccatccttgg taagaagagc ggctcctact tggaatttgg 2442661 aatacggcgc atatgccata tcacgcgctt ttaaagcttc tgttattaat tcttgtctgt 2442721 tcatgtgtac attcctctct tacctataat ggtaccgcta tcactttata ttttacataa 2442781 tcgcgcgctt tttttcacgc ccatttctaa aaatgtaaaa taaatgtaag aattttcagc 2442841 cattacagct ttggcaaaaa aataagtaaa ccaatgatac acgaaatcac ggcaaaaacg 2442901 caaacagccc cggcggcagc gtccttggcc gctttagcaa gagggtgatg tttgtcagtt 2442961 attaaatcaa ccgtatgttc aatggctgta tttaaaagtt caagcgaaaa cataccacct 2443021 atcaaaagga atataatcat ccactcaata atgctgagct ctacaaggaa gccgcaaatg 2443081 agaacagcgc aggcggctgc ggcatgaaat tggaaattcc gctccgtccg cgctgtttcc 2443141 catatgcccc ggcctgcatg cacgaagctt ttgaagaatc gattcagctc atttctatga 2443201 tcttttgagt ccataagcgt ccagcaattc cttttgctta gtaaacatct cctcttcttc 2443261 ctctttcgtc atatggtcat atcctaaaag gtgcagaaat ccgtgtacag ctagaaatcc 2443321 gagctctctt ttaaaagaat gattatactc ctctgcctgc tctcttgtgc gatcggcact 2443381 gatgataata tcacctaaaa ccggaggcat ttcggcgccc acgatttcga tctcgccttc 2443441 tccctcttct tcaagagcaa atgagatgac atctgtcgga gcatcctttc cccggtattc 2443501 tttgttaatc tgatgtatgt catcattgga aacaatcgtg acagaaactt cagcctgatc 2443561 ctgaacgcct tcacgctcag cggcaaattg aagcagattt tctacttctt tgagcatctc 2443621 ttctgagacg cttcccgttt catcaacgat atcaatcagt aaactcatct atttcacctt 2443681 cttagtagcc tccggatatt caatccggga gtggaaaatt ccttttaatg ttgcacagag 2443741 cgtttttgcg attgtatcca gctctttaaa tgtcaaatcg cattcactga actgtccgtc 2443801 ctgaagctta tcggatataa taccccggac aagcttttca attcgttcag gatttggatt 2443861 gtgcatggat ctgacggccg cttcaacact gtcggccact gatataattg cggcttcctt 2443921 tgactgcggc ttcggtcccg gataacggaa ctcttcctct gtaatctggt cgcctttttc 2443981 cttcgcttta tagtaaaaaa actttaaaag cgaggttcca tgatgctgct cagcaatatc 2444041 gacaagctct ttcggaaatt tatagcttct cagcatattc gcaccgtctg tcgtatgcga 2444101 gataataata tttttgctca actgaggtga cagcttgtca tgcggattgt caatattcat 2444161 ttggttttca ataaaatatt gcgggcgctt tgtttttccg agatcgtgat aatatgcgcc 2444221 gactcttgca agcaaaccat tagccccaac cgcttcacag gctgcctctg ataaattggc 2444281 aaccattaca ctgtgatgat atgtacctgg tgtttccgtc agtattttgc gcaatagcgg 2444341 atggttagga ttagacagct cgagcagcct catggtggat aaaatgccaa agcccgtctc 2444401 aaaaaacggc atcagaccga tgatcaatac agatgaagca aaccccgaca caacccccat 2444461 gagcattaac gtgccgattt caagacccga cagcgcagtg ttctggatca ataataagga 2444521 tagaacgaca accatattaa taaacgccac gaaaagtccg gtctgcaaaa tctttgatct 2444581 tgcattgtgt tttcctaaaa ataatacacc tgaaatgccg ctgatcaaat aataaatccc 2444641 tatgacataa ttgaatgttc ctgtcacacc ctgattaaac atcatacttc cgcaaatcgc 2444701 aagaatgata cttcccaaaa tggcaatgcg ttcattcatc agcagtttga ttaagatggc 2444761 gccggccgca atggggacca gatagccgat attattatac tccatcttct gaaacaaact 2444821 gacaacctcc atgatcacaa gcaaaagtgt tgtgattatg gagaataaca gaatggattg 2444881 gtttttaaac ttcagatttt gtttctgttt ttcaaaataa tatacaagtg ttgcaatgaa 2444941 aagtccgatc ataatcaata gcccgctgat cggtttaaag agatttgagt tatttaataa 2445001 cccggtcagc tcaagtttcc tgtacacttc ccgatcaatg aggtcatttt cttccacgag 2445061 cacttgcccc tgtttgattt gaacctgctg gacattatct gaggcttcct gccgttttgc 2445121 ctctgttgct ttcggatcga agacgtaatt cggaataata gcaaaacgcc cgatttctgt 2445181 cgcggctccc aagtatttag acggaataga attgctcttt agctcttttt ctaccttatc 2445241 ctttgcatca gatagtttat ccgaagggat ttcactgctc atgaccgtat ttaccgcggt 2445301 aatgaccgta tctctgacaa aagaaaagtc ttcactgtct gctttcagca atgtcttgat 2445361 ggaatcctcc gatatagaat cattcacatc tgatgtcaat ttgtccttta cagatttgac 2445421 cattgatttt tccgatggtg atttactgcc ttcttccgat gattttttca cttcactaat 2445481 actgtcgaat attgatgaca caaggtcaat ccgattgtct gtatattctt tttttaatgt 2445541 atattgatct tcaaccgcgt cctcagcggc ttgctttttt tcctctgtgg ctttttgatc 2445601 ttctacggtt gccggagcgt aaatggtctt gtcgctgact gaaaacaggt ctaaatcaag 2445661 tgtttccggc ttaacatgta caaagagcaa agcaaacata atggcagcca gcagaagata 2445721 cagcagtaca tgcatggagc gggcattttt aaaactgctc catttttttg agctgctttt 2445781 ggtcttagcc ttctttttca acacaagaac ctcctcttga aacatcaagc ccataagcaa 2445841 tcataaaaat gacccgataa cgcgcgatcg ggtcattcag cattaatttt gcttatcgta 2445901 tgcttcaata attttcgcaa caagcggatg tctgaccacg tctgtctggt ctagctcaat 2445961 catagaaatg ccgtctattc ctttcagcat ctccttcgct actgcaagtc ccgatttgac 2446021 gcctttcggc agatcaattt ggctaacgtc acctgtaatg atcattttag agccaaaacc 2446081 cagtctcgtc aaaaacattt tcatttgagc aggcgtggta ttctgtgctt catcaagtat 2446141 aacataagca tcatcgagcg tccgtcccct catatatgcg agcggagcaa tttcaatgat 2446201 gcctctttcc atcagacgtt ctgtatgatc tgccccaagc acatcatgga gagcgtcata 2446261 cagcgggcgc aaataaggat ctactttttc ttttaggtca cctgggagaa aaccaaggct 2446321 ttcaccggct tccacggcag gtcttgttaa aatgattttt ttgatatgtc cgttttttaa 2446381 agcatggact gcttttacga cagccaggta cgttttcccg gttcccgccg gaccaatgcc 2446441 gaatacaagg tcattccgct tcatagcggc cacgtattcc cgctgtccca ttgtttttac 2446501 acggattgat ttgccttttg cgttttttgt aatttcttct tcatacatgc tttcaaagta 2446561 ttcaagttca ttcttctttg ccattttgat ggcgtaaatc acatcacgtt cagagatctc 2446621 tatccccttg cgaattaaag cgaggagcga tcccagcagc ctgtctgcaa tctgaaacga 2446681 ttcatcatcg cctgaaacat aaatcgtctc gccgcgcgta atgatattta aattcagatc 2446741 tttctccatc aatttcaaaa aagaatcttg gttcccgaag agtgaaagcg cctcgtccgg 2446801 gtttttcagt ttttgattca tcgcaagtaa atgttctgtc attcttcagt ctccctgaca 2446861 ataggtgtgg tttgaacgat atcttctata acttggtaga gaataatcaa ctttacttta 2446921 ccattctcaa cagtctggtg caaaactttt tcacttttca cctcgccgtt ttcgcctatt 2446981 ttatcctcta catcctgttt acccaattta atgccttctt gaactgcttc ttcttttgta 2447041 tattttcgca aagcctcttc actttctctc gtttgctctt tgacatagga tacagggagc 2447101 ttaaatccga gaaaatgaag cgaatgcttt tcttgttctg tttttggatg cttcaattcc 2447161 tcttttttaa acgtcatccc ccagatcggg attgccaaag aaccaaaaga aagcttgtgc 2447221 tttgtcctta ctttgcccgt atagacgtta aataatgttt caagcgggac tgtcacttct 2447281 gatctatacc aggtttctcc ataaatttct gcttttgagg cgacttcctg ctgatggtct 2447341 tcgctgccga tcagtcccga aacaagcagc tgtccctttt caacatgatc gtgtatggcg 2447401 gccatgggct gtcctttttg cacaaacatt ctcgtaatgg ttgctttctt tttggcgaca 2447461 atattgcgcg ggctaacata tttttctttt tcgggctcat ttttctccac aactttcata 2447521 tgaatggtcg tccccttcag atcaactccg acccaagtga tattgtctat tccattggtt 2447581 aatgatttct gtattttttc gggcgacatc attaaaaact gcagacggcc ctttttgacg 2447641 ccgatttcat taagatgctg cctcatttga tgttctgttt caggcttagc gcctgtcaca 2447701 tcaattttcc acaccatatt ggacagcaaa aacaaaagaa tgaaaaaaat cgcaaaaccg 2447761 atcgtaaacc ctatattcag ctttgatttc agcaacagga agggaaatcc cttccgattg 2447821 ataaatcggg ctttacattt aaatttactt cttacccgcc gaaaggcatg tacatcctga 2447881 agctgtatat ataacgatac ggcttctttc ttttttttga catgaaagac cggaatcccc 2447941 tgtcttgtgc attcattaag gagccgctca atccctcttc ccgtcaattc aagctggacc 2448001 ttacccgaaa aaaaagacag ccatttattt ttcacaacat ttccccctcg gctttatgac 2448061 tcaacatatc gaacgacatc aatcgtaccc tccaaaagta tctcttccgg aagaatcgcc 2448121 ttgatgacaa aatttttacc agatatgatg cactggccct gcttcagcat cagccgcact 2448181 tcattctcac tgaaaagcaa aaggcctctg tggttttcta tgtagatatg aagtctgcca 2448241 accattgtaa tcctcggcag atccatcata acgtccgggg gaatttccaa tgctcttgtc 2448301 agccaagctt tcatacgatt ctttctttgc cccatacaaa aagaaccccc tttcatctca 2448361 tatgtatgat ttgaaaggag gttctaacac tttaattttt acgggccggg cgcatcgtac 2448421 ggtgaggttt tttcgcccgt ggaggtccga acacctctcc tagaacgatc ccctgtacga 2448481 cggtgtcttt attcacctga agcatttttt gttttgtgta tactgttttt tgtttggcag 2448541 cagcaagatc tcgttccagc cctttcaggt ttcttgctgt ttccctgcgt ctttcttccg 2448601 cttcccgtct tgcctgttcc atacggttag ggataggtgc aggggcatct tcttttgact 2448661 gcttcttttg aggagaagca gattgcacgt gttgaggttt ttttcttttt tggctgtttt 2448721 gcttttcttc tttgctcttt ttgccgaaaa tcgcagaaat gattccgatg atcgctgcaa 2448781 taataagcgg attggtcagt aaatcttcca tcagcgttct cccttcttag agagattatg 2448841 atttgcggtc ttcatccgaa gggtctttcg tcagcttgcc gaatgaatca cgcatttctg 2448901 tgtcagcatc gatgttcttg atattcatgt aatccatgac gccaatattc ccttcacgca 2448961 aagcttctgc catcgcaagc ggcacttccg cctcggcttc tactactttc gcgcgcattt 2449021 cttctacgcg ggcacgcatt tcctgttctt gagcgacagc catcgcacgt cgttcttccg 2449081 cttttgcctg cgcgatgttt ttatcagcct cggcctgatc ggtttgtaaa attgccccga 2449141 tgtttttgcc gatatctaca tctgcaatat caattgagag aatttcaaac gcagttcctg 2449201 agtccaatcc ttttccaagg actgtctgag aaatcatgtc agggttttca agcacttttt 2449261 tatgattatc agatgaaccg attgtagaaa cgattccctc acctacacga gctacaatgg 2449321 tttcttcccc tgctcccccg acgaggcgct cgatattcgc tcttactgtg attctcgctt 2449381 tcgctttcac ttcaatcccg tccattgcga cgccggcaat gaacggtgtt tcaatcacct 2449441 taggattaac gctcatttga acagcttcca acacgtcccg gcctgcaaga tcaatggcag 2449501 cacagcgctc gaatgtgagt tcaatgttag ctcgctgagc ggcgataagc gcgttgacga 2449561 ctctgtcaac attacctcca gccagatagt ggctttcaag ctggtttgtt ccaacattaa 2449621 gtcccgcttt atgcgcttta atcagcgggt taacaacccg attcggaatg acgcggcgaa 2449681 gcctcatccc aactagagtg aaaatgctga ttttcactcc ggctgccaaa gctgaaatcc 2449741 aaagcattac aggcacaaat gtaaaaaata ctgccaaaac aatgatcgct actgcgacaa 2449801 ttgccagaat cataagtgtt gacggatcca tataacttct cctcgtttct atttaaattt 2449861 ctctcacgac aatgcgtgag ccttctactt ttatcacttt tactttttta tctttttctg 2449921 taaacgatcc ctccgataca acgtcaaggc gttcatcatc aataatcacg gtaccggaag 2449981 gacgcagcgg tgtaaaggtt atacccactt ttcccattaa gtccgtgcgc gtttgatttg 2450041 aaacgtagcc gctctccgtg tttgtagaat catttaatat caatttctta aagaatttca 2450101 tacgctttcc caacaccctt gtcagtaaaa taaaagctgt aatcgaaaca gctgaggcga 2450161 tcaagagaga aaccgccatg acagtgaagc tccccgcggc taaaaacagg ctcgcaataa 2450221 tcgctcccaa gcccagtaat ccaatgattc ctccgggaag aaaaatctca agcagaatga 2450281 gaatcacccc tgctataaag aggagaaccg tctcataccc ggcaaggccg gctgcaagat 2450341 gcccgtaaaa gaacagcaat aacgcaatga gtccagccgt tccagggagg ccgacacccg 2450401 gggaaaaaag ctctaccgtc agacctaaaa aagcgattgt cagcagaata gggacaatga 2450461 ccggattcgt cagccatctt gccgtctttt ccgcaaagct ctcctttgca tagctgatct 2450521 gcgccttttc gaacccaagc ttctttacga gcgtggacaa attgtcagca gtgccttctg 2450581 aatagcctac ctcaatcgcc ttgtctgcgt taagtgtcag cagatctccc ttaggcgcgc 2450641 caacttcctt ggcatctata tctgggtcag ccattgcgag cgcatatttt ggatcgcggt 2450701 tatttttcac tgcggcatct tccatctctg ccagccaaag tgattgagct ttttggtcag 2450761 cggcattgcc ttggccatca acaatcgcgg cggctcccat ttttccgcca ggcgccatat 2450821 aaatgtgatc tgcttgaagt gcaatatatg caccagcaga caacgcgcgt ttgttgacat 2450881 atgcagttac ggggatctcg ctttcggtta tcaaatcggc catatcaata gcagatttga 2450941 ccaatccccc cggggtattg atatcaagaa taatatggtc tgcatgtgca tcctttgcgt 2451001 cttgtaacga acgggacaaa aacgaggcga gaccctgttc gacatttttt tcaaccggga 2451061 tcacataaac agtttgtttt tctgcttttg cgttcagctg tacgcctaat aaagaaagta 2451121 aaaatatacc caaaagagca gcacggaatc ctttgatttg aagcaagggc ggtgtatccc 2451181 tccttccttt tataataagt gccttctctt catacgtaac aaatgtatca aaggtttcat 2451241 ttttttatgt ataaaaaaag acatctctct tagaaagatg tccttttctt tgccatttaa 2451301 gacagttgac tgctcacaag cttattaatt aaacttccgt cagctttacc ttttacttta 2451361 ggcataattg cccccatcac tttgcccatg tccgcttttg agctcgcacc gacctccgcg 2451421 atggtttcat ttacgattgt acgcagctct tcttctgaca gctgctcagg taaataaact 2451481 tctaaaatgt ccagctcttt ttgaacttta tctactaaat ctaaacgatt agcgtttgaa 2451541 aattcctgga gggagtcttt acgttgctta agttcacgag aaaggacagt gagttcctca 2451601 tcctcggtca aactgtcttt cttaagctta attgcttcat tttgaagtga agccttaacc 2451661 attcgaacga cagtcagttt gtctttctca cggtttttca tatacagctt catatcctgg 2451721 ttgagacgct caagaagact cataaatcca ccctctttta gaatttgcgt tttctagcag 2451781 cttcagactt tttcttgcgc tttacgctag gtttttcata aaattcacgc tttcttgctt 2451841 cttgcaaagt acctgtcttt gatacactgc gtttgaagcg acgaagagca tcttcaagcg 2451901 attcgttttt tctaacgacc gtttttgaca ttctctttcc ctccctccga atacaccaat 2451961 cgactacctt taagttacac atataaacat gtactttgac attataatat aagccatcag 2452021 tcaggtcaac taagtgagtt cacttttccg tcatgagtgc gactgcctgt ctatataatg 2452081 aaagaaaggg gttggtgaat aggatgttaa ttctgattag ctttactgct cttatattat 2452141 tctttctcgc aggcatgaac atgcttcgaa agggcttaat ttcaatggcg tactcaaaaa 2452201 ttgaagaacg tttgctttta tttacagacc atccgttaaa agcgtttctt atcagtattg 2452261 tatttacggg gatacttcag agcagctcag cctttatggt cattgtcatc ggctttgtaa 2452321 gtgcgggcgt tctttctttt aagcggacga tcccgatgat tctggggaca aatgttggct 2452381 ctacttttac aactgaattt attgctatca aaatggatat tgtgatttgg gttcttttaa 2452441 taggaggttt attgtttttt ctgactggca ggtatccttt gaaacagctg ggaacaagct 2452501 tccttggact gggcatcatc ttcttttgca tcagcggatt cagccatctt gccgggccgc 2452561 tgacaaagct gaaaacgggc gccgacgttc tataccatgt taacgattca aactggtccg 2452621 ctttgctcat cggcatggtg ttaactgcca tcattcactc cagttctgtc tgtatcggca 2452681 ttttgatgag ttttatgaat gaagggatta tcggactgac acaggcgatg agcgtcgtac 2452741 tcggatcaaa tatcgggaca tgcattacag ctgtcatggc tgctgtatcc ggcggatatg 2452801 cggcgaaaca gacagcatat gcccatgtgg tatttaacgt gctaggggtg gctctagtat 2452861 tgccttttct gaccgcagcg accggctttg tagagcagtt atcacctgat cccgcacaaa 2452921 agatcgcgca tttcagcctt ttatttaatg tggtgacagc tcttttattt cttccgctta 2452981 caaacttgtt ttaccgattg attcaccttc ttatcccggc taaataaaaa aatcggtaca 2453041 ttttaatgca ccgatttttt aggttaagaa gacaaacgca tgtgttcagt tatttcatcc 2453101 tcaaccacac ggacaaactg tccttcgttg taaggataac ctgcttttag gattttgact 2453161 tttacgattt tgccgatcat atcttccgta cctttgaaaa caaccttcat ataattgtct 2453221 gtgtaaccga caaacatatt ttcttcttct gtttccttaa acgcttcctc agggataatc 2453281 tcaagcactt cattttcata ctgagaagcg tattcttttg caagctggtc agaaagagca 2453341 atcaggcggt gcacacgttc gtttttcacg ttttcatcca cttggtcttc cattcgtgca 2453401 gctggtgttc ctgtacgctt actgtaaggg aaaacatgca gctcagagaa tttatgttct 2453461 ttaataaagt tataggtttc cataaattct tcttctgttt ctccagggaa cccgacgatg 2453521 acatcagaag taacagctaa gcctggcagt gcttttttca atttatttaa acggtctgca 2453581 aagaattcca ttgtatattt gcgtctcatc cgtttaagca ctgtgtttga tccggattgg 2453641 ataggaatat gcaaatgatt cactatctta tctgagcggt ctaagacctc gatcacttcg 2453701 tcagtgattt ggctggcttc gattgaagaa attctgatcc gtttcacgcc ttccacacgg 2453761 gtgtctaatt cgctcaaaag cttcgcgaag ttgtaatctt tcatatcttc gccgtagccg 2453821 cctgtatgaa tacccgtaag aacaatttcc ttatatccgg catcgacaag ctgctgcgct 2453881 tgtttaatga cttcttcagg gtcgcgggag cggagcaggc ctctcgccca cggaatgata 2453941 cagaatgtgc agaaattatt gcagccctcc tgtattttca atgacgctct tgtgcggtcc 2454001 gtgaaagcag gcacatcaag ctcttcatat actcttgctt tcatgatgtt gctgacgcca 2454061 ttaatcggct ggcgttcttc tcggtattgg tcaatgtagc caagcatttt ttcacggtcc 2454121 tgtgttccga ctacaatgtc gacaccgggg atcgccataa tctcagcagg tgaggtttgc 2454181 gcgtagcagc ctgtgacaca gatgacaccg tcaggatttt gacgaatggc gcgtctgatc 2454241 acttggcggc tttttttatc tcccgtattt gtaaccgtac atgtattaat gacatataca 2454301 tcagctgttt gttcaaagtc tcttctttca tagcccgctt ctttgaaaag ctgccagatt 2454361 gcttctgttt cataatggtt gactttacag ccaagcgtat ggaaagcaac agttgccatt 2454421 actgatcacc tcttaataac tctgtttgat aagaaatcgc actcaacgcg tatagcggag 2454481 cggtttctgt ccttaaaatt ctcggtccaa ggccgcacgt cacaccgtct tgctctgtga 2454541 gccgttcaac ctccgcttct gttaaaccgc cttcgggacc aaatacgatc aatagagatg 2454601 atcctttcgg aaggctgctt acaatcgcgc tgaatgcgct tatttcccct tgcttcgatg 2454661 actcctcgta tgcaacgaca catttatcga aatcctgcat cctttgaaga agctgctgaa 2454721 aagaatggac atccatcact cgcggcactt cgttacggta cgattgctca gccgcttcct 2454781 tcgcaatttt cgtccatctt tcccgctttt tctttgcctt tttgtcatcc agcttgacaa 2454841 cagaacgcgc ggcttggaaa ggaataaagg catgagctcc gagctcagtc cccttttgga 2454901 taatccattc aagcttatct cctttcggaa ggccgctcgc aatatagacc tttatcggaa 2454961 gctctctgtt ttcattcgtc cattctatca caaggcagga cactttatct ttggaaacag 2455021 attgaagttc acattttgcc tcgaagccgt cttgagagca gcagataatc tgatctccct 2455081 cattcattct catcacgttc acaatatgat gaacttcttc gccggtaatc gaaaaagtcg 2455141 gcgcttcctc tatttgctgc ttcgtgagct cgataaaata tcgttgcata cgctgtgaca 2455201 cctactaact gttatttttt cgcaataatg ctgacccaat cttccattga aaggatttct 2455261 acaatggtaa agccagcttg ttccagtgct tcttttactt cttgtttttt atgaccgatg 2455321 attcctgacg taataaagtg accgccttct tttaacaggc tgtacgcttg tgaagtaaag 2455381 cgaagaatga cttcagccaa aatgttggcc acaatcacat catgttcccc ttcaatcccg 2455441 tctaacaaat tgttttgctt cacttgagca atatcgctga ctttgttcag cttgagattg 2455501 aggcgtgcac tttctacagc cacgggatca agatcgtagg catgaaccga ttcagcctca 2455561 agcattgcag ccgcaatact taaaattccc gaaccagtgc cgacatcaat caccttatca 2455621 cccttttgca caaagcgttc aagcgcctga atgcagagta cggttgtcgg atgtgtccct 2455681 gtgccgaaag ccattcccgg gtccatttca ataatcagtt catcagtatg gaccggcgta 2455741 tattcctccc acgtcggcac aattgtaaac ttttcagaaa ttttcacagg atgataatac 2455801 tttttccagg cagtcgccca ctcttcttca tttacttcag aaatagtgat gtggtttctg 2455861 cccaaatcaa tattgtaaag aaggagatta ttaatcgttt ctttgatgcc gtctacagtt 2455921 tcgcccagaa aactgttaac cggcagatat gctttgacaa tgacaccctc atctgggtaa 2455981 tcattggggt cgagctggta gatttccccg tacacattct cacgttcttt aattaaatca 2456041 agcgggtcct ctatcacaac cccacttgca ccagcttcat gcaatatatt tgagataggt 2456101 tcgaccgctt catgtgttgt gtgaatgctt aattcggacc atttcaaaac taccaactcc 2456161 tcatccaata attaatcgcc tttaaacgcg cgttttacct tgtcaaagaa actcatttcc 2456221 tgttcgtcag gcaggtttcc gctgacttcg gcaaattcgc ggataatgtc tttttgttta 2456281 tcagtcagat ttgtcggcgt aacgacgcgg acgacgatat gctggtcacc ctgtccatag 2456341 cctctgacat tttgaacgcc tttgcctctt aatctgaatt tcgttcctgt ttgtgtaccg 2456401 gccggaattt tcaatttcac ttttccatgc agcgtcggca cttctacctc atctccaaga 2456461 gcagcctgag caaacgttaa cggcatttca cagtaaatat catcgccgtc acgctcgaag 2456521 aactcgtgtg cgcgtacatg gaacacgaca aataaatccc cggcagggcc gccgtttatt 2456581 cctggttcac cctgtcccga gagacgaagc tgctgcccgt catctacacc ggctggaatt 2456641 gtcacattga ttttcttgcg ttttttgatt tttcctttgc cgccgcagtc cgcacatttg 2456701 tttttaatga ttttgcctgt accttcacag tggtggcaga cccgtctgtt aacgactttt 2456761 ccaaacggtg tattttgctc cacgtttaac tggccggagc ctccgcagtg ggagcatgtt 2456821 tctggatttg ttccaggttt cgcacctgag cctttacatg tttcgcacgt ttcctcgcgg 2456881 ggaatttcga tggttgtttc tttaccgaaa gccgcatcct caaacgacag ggtcatcgta 2456941 tactgtaaat cagcaccctg gcgcggagcg tttggatctc ttcgtcttgt gcctccgccg 2457001 aatatacttg agaaaatatc atcgaaacca aaaccgccga aatcgccgcc gccaaaacct 2457061 ccgccgccga agccttggtt agggtcagtg tgaccaaatt gatcgtaatg cgcacgtttt 2457121 tggtcatctg acagcgtttc gtatgcttct tttacctctt taaatttttc atctgatccg 2457181 gcttctttgt taatatcagg atgatatttt tttgacagct tccgataagc ttttttaatt 2457241 tcatcctttg aagcgctctt acttactccc agcacttcat agtaatcacg cttactcatc 2457301 tcgcttcact ctcccgaatt tctcacataa attagattgt atcattttga attatgattt 2457361 ttcaattcct tttatcccgg gcaagaaaaa aagtcaaagc caagagatgc ctgactttga 2457421 ctttctaatc attgaatcag attatgaaat gtgttctttt cggtcagctc cggaagcggg 2457481 gctgacacta aaaagaactt attttttgtt ttggtcgtcg tttacttctt cgtattcagc 2457541 gtcgacaacg ttgtcatccg ctttgccttc agcgtttgct ccgccttgag cttgctgtgc 2457601 tttagcagct tcttcataaa gcttcataga aagctcttga acgattgttt gaagctcatc 2457661 ttttttcgct ttgatctctt caaattcgtt tttctcaatc gctgctttta aagcgtcttt 2457721 ggcatcgttg gcttttttca cttgttcttc gtccactttg ccttcaagat cttttaatgt 2457781 tttctcagtt tggaaaacaa gctgatctgc ttcgttgcgg acttcgattt cttctttttt 2457841 cttcgcatca gcgtcagcat tttcttccgc ttcttttacc atgcgttcga tctcttcatc 2457901 tgagagacct gaagaagatt tgattgtaat gttttgttct tttcctgtgc ctaagtcttt 2457961 tgctcttacg tttacgatac cgtttttgtc aatatcgaaa gaaacttcga tttgaggcac 2458021 gccgcgcggt gctggcggga tatcagtaag ctggaagcgg ccgagtgttt tgttgtcggc 2458081 agacattggg cgctcacctt gaagaacatg gatatcaaca gctgtttggt tatcagcagc 2458141 agttgagaac acttgagatt tgcttgttgg gatcgtcgtg ttgcggtcga tcagttttgt 2458201 aaacacaccg cccattgttt cgataccgag agaaagcggt gtaacgtcaa gaagaacaac 2458261 atcttttacg tcacctgtga taacgccgcc ctgaatcgca gcaccaagcg ctacaacttc 2458321 atccgggttt acgcctttat gcgcttcttt tccagtttct tttttgattg cttcttgtac 2458381 ggcagggata cgagttgatc cgccgacaag gatgactttg tcgatttcgc ttgcagaaag 2458441 tcctgcatct tgaagcgctt gacggacagg acccattgtg cgctctacta aatgagaaga 2458501 aagctcttcg aatttagcgc gagttaatgt aagttcaagg tgaagcggtc ctgcttctcc 2458561 agctgtgata aacggtaaag aaatttgcgt agaagatacg ccggaaagat cttttttcgc 2458621 tttttcagct gcgtctttca aacgctgaag cgccattttg tcttttgaca aatcaatgcc 2458681 gttttctttt ttgaattcag acaccagatg atcgatgata acttggtcaa aatcgtcccc 2458741 acccagacgg ttgtcgccgg cagttgaacg aacttcgaat acaccgtcgc caagctcaag 2458801 gatggaaacg tcgaatgtac cgccgccaag gtcgtatact aggatcgttt gatcttcatc 2458861 tgttttatca agtccgtatg caagcgctgc tgcagtcggc tcgttgatga tacgttctac 2458921 ttcaagacct gcaattttac cagcgtcttt tgttgcttga cgctcagcat cgttaaagta 2458981 tgcaggaact gtgataactg cttttgatac tgtttcgcca agatagcttt cagcgtatga 2459041 tttaaggtgt tgaaggatga tagcagacac ttcttgtgga gtgtaatcct ttccttcaat 2459101 ttcaacttta taatcagtac ccatatgacg tttgatagac ataattgtgt tagggtttgt 2459161 aatagattgg cgtttagcca cttcccctac ttgacgttcg ccgtttttaa atgcaacaac 2459221 tgatggcgtt gtgcggtttc cttcagcgtt agcaataact ttaggctcgc cgccttcaag 2459281 cactgccaca catgagtttg ttgttcctaa gtcgattccg ataactttac tcacttgaat 2459341 aacctcctgc tatgtaatta ttgattcact ttgaccatgg aagggcgaat gacgcgatcc 2459401 ttcagcttat agcctttttg catttcctca acaacaatgt tggagccgta gttttcgtct 2459461 tcagcctgca taacagcttg gtgcagatta ggatcaaatt cctgccctac agcttcgatg 2459521 gcttcgacgc cttctttttt caaggcttct acgagctgac ggtggaccat ttccattccc 2459581 tggagcaaac ttttcgtctg ttcattgtcg gcttcaacct gaagcgctcg ttcaaaactg 2459641 tcaagagccg gcagcaaatc agtcacgata ttttgagaac ggtatttttg ggacgcttcc 2459701 atctctaaac ggctgcgtcg tttatagttt tcaaagtctg cttgaacacg caaaagtttg 2459761 ttttcttttt cctcaagcaa accttgcaat tcgttaattt ggttttgaag aagttcgctt 2459821 tcatttgttt cttcctgctg ttcatcagcg gcagcttgtt cttcaatgat ttcttgctct 2459881 tctgtttcgt tttgttcaac ggtttgtttt tcttctgaca ttgtgttcac ctccctcaaa 2459941 gtgtaaggag aaggacaggt gctgcccttc gataaaattt gccaaaattc ccttattcat 2460001 catacagact tgttaatgct tttgacaagt ccgaagtcac atgctgaagc aggctgacaa 2460061 ccctggaata attcatgcgg gtcgggccga taatcgcaat tgagccgatc tgcttctggt 2460121 ctacggaata agaagccgta atcagactgc aattttccat ctcttcatag tcgttttctt 2460181 ttccgatttt aatcgaaatt cccgtgtgcg gggattgaac cagctttaaa acatcctgtt 2460241 ctttctcaat taatgaaagc agcgaccgaa ctcgggtgat atcatggaac tcaggctggt 2460301 tcagcatatt gattttcccg ccaaaaaaca acttttcaac gtgatttgtg gaatgaaagg 2460361 ttgaacgaag cgcgtcgagt atattgtcat agtttttaat gtgctgtctt aggtacatga 2460421 caacttcttt aaatatgcgc tcattcagtt catccattgg aacgccgctt aaacggtcgt 2460481 tcagtatatt taccagtttt tcaatatcag acagatccat tttggtcgga aagttaatcg 2460541 ttttgttttc cacatgcccc gtattggtaa cgagaatcgc taccgccata tcaggctgaa 2460601 tcggaatgat ttgaatctgt ttaaggtaat tctcactcaa cttcggcccg agtacgatgg 2460661 atgtgtaatt cgtcagatcg gacaaaattt gcgctgattt ttgaactgtc ttctccagct 2460721 cgaaaatttt ctctttgaag atcgagtgga tttggtccag gtcgcttttc gtcaatttga 2460781 cgggtgacag caaatggtca acatagtacc gatacccttt ttctgacgga acacgtcctg 2460841 aggatgaatg ggttttttca ataaagccca attcctccaa gtcagccatc tcgtttctta 2460901 ttgttgcaga gctaaatgtg atttcatctt ttttcgaaag agttcttgat cccaccggct 2460961 gtgccgattt aataaaatcg ttgattataa cctgaaggat cagcagctga cgatttgtta 2461021 acatcatcat cacctctgtt agcactctca ataagcgagt gctaattcta taacaaaagt 2461081 atcaaaccac aagaaaaatg tcaattataa ctcacccaaa aaagcgccaa aaacttcatt 2461141 gcctaataat ttcccttgat gagtcaaata aacggcagac tccgaattgt gaatcagccc 2461201 tttttcagcg aggtctttta acacgcttgg gaaaagtcca tccagggaac ggccgtattt 2461261 ttctgcgaat cgttttttgc tgacaccggc tgtttttctc aaacctaaaa acatttcttc 2461321 ctcaatctgt tcttctgttg tcacttcatg tgtatctctg tacggaaaac ccttttcagc 2461381 tatcaggtca atgtaatgct taacaggtcc gacgttcact gttcgtgtgc cgccaatata 2461441 tccgtgagcg ccagctccga aaccgaaata ttgttcgttg ctccaatacg ttagattgtg 2461501 cttagattcc atgcctgcct tagcaaagtt gctgatttca tattgatgaa tgccgtgagc 2461561 ttccatcttg ctcatcacta tttcatacat ttcagcttcc tgctcctgcg gcggaagatg 2461621 aagccgccct ttttgcatca aattataaaa taccgttttc ggttctacaa taagggagta 2461681 aacggaataa tgctcagcgt ccaatgataa agcagtgttt atggaatgtt ccagatgctt 2461741 gagggtttgc cccggaagcc cgaacatgag atcaagactg atattctcaa aaccgatttc 2461801 ccgcgctctt tcaaaagagg tgaatacatc tttttgcttg tgcactcggc cgattttttc 2461861 taacagatcg tcttcgaacg tttgcacacc aaagctaagg cgatttacgc ctgcttcttt 2461921 taatattttt aatttctctg cggacaaatc gtccggattc gcttcaaccg caaattccga 2461981 taagtcgctt gagggcttta gcacgcggtt gatcatatcc atcagctttt taagctgttc 2462041 ctcagacagg gaggtcggcg tgcctcctcc gataaagatt gttttgagat caggctgccc 2462101 ggtttttgct attgtattta tcatttcctg ttcgagtgcg tttaaatact cgtcgactgg 2462161 ctgactttga ataaaatatt tattgaaatc gcagtagtgg caaatatgct cacaaaatgg 2462221 gatatggata taagctgatt tcaacggatt caccttcttt acagaaagaa gccgcagtac 2462281 aagactgcgg cggcttctat tgttttttcg gactgtcgtc cattttcaga actgccataa 2462341 atgcttcttg cggcacttca actgagccga cctgcttcat acggcgcttt ccttcttttt 2462401 gtttttcaag aagtttccgt ttacgcgaga tgtcccctcc gtaacattta gccaatacgt 2462461 ttttacgcat tgcttttatg gtggagcggg ccacgatttt ctggccgatt gcggcttgta 2462521 ccggaacttc aaactgctgg cgcggaatga gttctttcag tttttcaacg atcacttttc 2462581 cccgttcata tgcgtaatca cgatgcacga taaaggaaag ggcatcgatt ttttcaccat 2462641 tcagcataat gtccattttc acaagcttgg acggtttgta gccgatcagt tcataatcaa 2462701 aggacgcata gcctttagtg cttgatttca gctgatcaaa aaactcatat acgatttccg 2462761 ctaatggcat atcataaatg atgctgacac ggtttgcgtc taaatactgc atatcaatga 2462821 aattgccgcg ttttccttgg caaagctcca ttacagcgcc gacatagtca ttcggcacca 2462881 tcatcgtcgc ttttacgtat ggctcctcaa ccctttcgat cttttgagga tccggcatgt 2462941 tggacgggtt gtcgacaacg accttttcgc cgtctgtcat atacacgtca tagataacgc 2463001 ttggcgctgt cgtaatcagg tcgatgttga actcacgctc aattcgctcc tgaatgatct 2463061 ccatgtgaag catgcctaaa aatccgcagc ggaacccgaa tccaagcgct tgcgaagttt 2463121 ccgcttcata ttgaagggag gaatcattca gctcaagctt ttcaagagct tcccttaaat 2463181 cattatactt cgctgtatca atcggataca aaccacagta caccatcggg tttagcttgc 2463241 ggtatcccgg cagcgcttct tctgcaggat tggcagcgct cgttattgta tcaccgacac 2463301 gtgtgtcacc aacatttttg attgaggcag tcaggaagcc tacatcaccg accgtcagtt 2463361 catttgtcgg agttgctttc ggcgtgaaca cgcccacctc tgttacttcg aattctttgc 2463421 cggttgccat cattttgatt ttttgtcccg gctttaccgt tccttcaacg actctgatat 2463481 aagccacgac accgcggtag gcgtcataaa gcgagtcgaa gatcagcgct ttgagcggcg 2463541 cctccggatc tccggtcgga gctggcacct tttctacgat ttgttctaaa atctcctcaa 2463601 tcccgatacc ggcttttgct gaagcaagca cggcttctga tgcgtcaagg ccgataacgt 2463661 cttctacctc ttggcgcaca cgttcgggct cggcgctcgg aaggtcgatt ttattgatga 2463721 ccggaaggat ttcaagatcg ttgtcaagcg ctaagtagac attggcgagc gtctgcgctt 2463781 caatcccctg ggctgcatcc acgacaagaa tcgctccctc gcaggcagca aggcttcggg 2463841 atacttcata cgtgaagtcg acgtgtcccg gcgtatcgat tagatgaaag atatattctt 2463901 ctccgtcttt tgctttatat ttaagctgaa cagagtttaa tttaatggtt atgccccgct 2463961 cacgttcaag atccatagaa tcgagcaatt gttctttcat ttctcgttga gtgattgccg 2464021 acgttttttc taaaatacga tccgctaagg tcgattttcc gtggtcaata tgggcaatga 2464081 tagagaaatt ccgtattctc gattgcctct ctaaacgctt ttctttatct gtcacaatct 2464141 atcactccta ctattaaacg caaaatacac tagcttagat tatatcaata ggattgtaaa 2464201 gattcaatgt aaaacaagaa agagaaaagt tccctatcat atctgggttg cttttctctt 2464261 tcacgtactt attgattcat atcccgtatc cattcataca ttgactgggc agtattggtt 2464321 acggtgtccg aaagcgcttt tccggctttt gaaaacatat tgaatgtctc caccttttcc 2464381 agctcttttt gtttttctac taaatctttt gccgtgactg tttctcctag gattgaggct 2464441 tctttttcat tatcttttcc gtcggtgagc gtaaacgccc ccttcagtga agggtcatga 2464501 tagcctttca tactcagcat cccgtggttt gcctgctgca tgccgaacag aacgcctaaa 2464561 aacatgatcg tgacaagcag taagcacttt ccaaagtatg caatcaaatc aaccacctat 2464621 ttcttattgt tttttcgtct ccccgctcgc tgcgttgacc ttttcagcat cccagtacat 2464681 ttcgctgaat acgtccgcgg ccgcgttagc cgcacgctgc agctcttcga gattattatc 2464741 cactccgcca aactcgagca aaagcgctct atcggttaaa tcctgattgt aaacaccatt 2464801 atcgcctggc gagcctttgg aaaagacacc tgtgctaagt ccggggtatt ttttctccat 2464861 cagtttatga agctcactcg caattttata gttttcttcg aagtttttgc tttttttccc 2464921 gacgacaaag gctaccctgg catagctttt ccctttaatc gttgcggttg tgtctttttt 2464981 gcgccgagag tctctgtgga tgtcaatgat atattgcaga tttttgtttg aagcgagggc 2465041 gtctttcacg accggccttg attcatcata ggacctggca tagtttaagc cttttttatt 2465101 caattttgac tgtatatcgg ttttattcac tgtggctccg attccctggg attcaagcgc 2465161 ttgtccgaac atatctccta caagcgtgac attggcttta gaatggcgcg ccatgtcagg 2465221 atcggtctcg ccttttaata gagggagata tgattccgta ttgtgcgtgt gatagataaa 2465281 cacgaccttt ttatcacctg ttgtttgttt cggcggatct ttttgcgcat tatctgattg 2465341 cgtttgctgt ttttcaatct ctgccaaatt cgcttctctt tcttcctcca tcaccttaga 2465401 cggcggcggc gattccgcag gcatattcgt ataatccgtt ccttgtccag ctaacaaaat 2465461 ctcggtatca aattgtgcaa atcctggcag ctcccgaccg agaaagctcc gcggatcttc 2465521 gaggttaatg ctcgtcgcca gctttaaaga aagacgagaa agatgaaatg agctgtctgt 2465581 ttgagagagg tcagaagcga aataatggtt ttccatctgc agcaaatgtg caaatacgtc 2465641 acccggcaat tcttcagcaa tcccataaaa agagtcagac gacggcctaa gttccggccg 2465701 gagagacgtc agcacaccgg atagaacaaa aatcacgata aggcttacga taaatagaaa 2465761 gatggctttt accgctttcc ctccatttac cgcaacaaca atctgtctgt ttctgcgttt 2465821 atttctcatt gaatccctcc agcgcttgtc tagtaattac tctatgaaca agctagagga 2465881 agtagaactg tttagtgatt gtaggagcct ttgttttctt gtgacacttt ttcatgaagc 2465941 gctgtgttta atccgttcgc taaaacattt gccatatcgt cgataaatga atcgacttcc 2466001 ttcggtgtaa ccattaagtt gtgccctaaa ggcgaaagca cctcgtgaat gagctgccgt 2466061 ttttcatctt cttgaagggt tccgacaata cctaggaacg attggcgctg cttttgatcg 2466121 ggaagatcgt cttcagtgag cactttcttt ttcccaaacg tcatgcctgc cggaacaagc 2466181 gatcttgatg gcctgttatc cttcatttct ctgccaaaat gttttaatat gtagtccacc 2466241 gtgtcgctgg caattgtcac ggcatcaact actgtcggaa caccgatagc aatcaccgga 2466301 acaccaagcg tgtctttgct taaatctttt cgtttattcc ccactccaga ccccgggtga 2466361 atgcctgtat ccgatatttg aatggttgtg ttgacccttt ccaccgcccg cgccgccaac 2466421 gcatcaatgg cgatgacaaa atcaggcttc gattgctcaa tcacaccttt aataatgtca 2466481 cttgtttcga ttcctgttat ccccattaca cccggtgcaa aagcactgac aggcctgtaa 2466541 ccctcctgta cgttttccgg ctgaagctta aacaagtgcc ttgttaccaa cagattttct 2466601 actgccatcg gtccaagcgc atcaggtgtc acgttccagt tgccgagccc aacgatcaaa 2466661 cagctcgcat cttttgagat attaaggttt tcaagaaaag ctgagaattc ctccgcaaag 2466721 acagcagaga ccttctcctg catttccgaa tcattctccc tgattccctg tgcttcaagc 2466781 gttaaatagc gcccttcttt ttttcccgaa agctctgcgc cttcctttgt aacatcaact 2466841 gtgcggattt taatgccgcc gtgatcacgc tctttttcaa taaagccttt aatttctttt 2466901 gtcggcacag cctgctgatt ggccattgct tccttcgttt ccactgccaa atcggtccgt 2466961 atcaaatact gattcacatc cagctcactc tttttcatac aggggcctcc ttcacattaa 2467021 gtacctatat tgttgccatt tgctgaataa atcatgctaa aaagagaacc ttcaatgaaa 2467081 aatactttac atttatattg caatctaaag gtgtgtttga tagaatacaa tttgttctat 2467141 tgtgaagaag atttaacctt aagacactgt gctacaggtt gtatcttagg aggtgaaaca 2467201 catgccaaac attaaatcag cgattaaacg tacaaaaaca aacaacgaac gccgcgttca 2467261 taacgcgaca atcaaatctg ctatgcgtac tgcaatcaaa caagttgaag cttctgttgc 2467321 caacaacgaa gctgacaaag cgaaaactgc tcttactgaa gcagctaaac gtattgataa 2467381 agcagtgaaa acaggtcttg tacacaaaaa taccgcagct cgatacaaat caagactagc 2467441 gaaaaaagtg aacggacttt ctgcataata taaaaacgat cctcaataat ggggatcgtt 2467501 tttttcattt ctttttaaca gctgtaaaag gaacagttcg agcaggagct gcttgtcctt 2467561 tttcccggtt ttcatctcat agtccatgac ggcaagctgt tcaataatta aacggagctc 2467621 ctcctctgaa aaaagccttg cttgatccat cgccagcttt acccgaaatg ggtgaacttt 2467681 tagattagaa gcgatttgtt tttgtccgta tccctgttcc gcgaagtact tcgtctgcag 2467741 aatcagccgg aactgattcg aaataagcgc cataattttg atcggttctt cattttgttt 2467801 tagcaaatca taaaaaattt gcagactctc tgttcgtttt cggttgacga ttttattgat 2467861 cagctcaaaa atattttgtt caaggcttct agcaacaagc atttttacat catccagcgt 2467921 aatttcttca cgatctccaa taaacgtgca gagcttttga atctcctgaa aaatcgatga 2467981 cagatgaccg ttcacaagca gaaccaaatg ctccgccgct tccgtgccga ttgttttctg 2468041 ctctgttttt gcaaggttga cagtaaagtc tgtcgtttcc tttgcattta attccttcgc 2468101 ctccatcata aacgcgtgct tctttaacgc tttcgtcagc ttttttcgct catcaagctt 2468161 ttcatacgga gcaagcagga caaagactgt gtaaggcgca ggtgattgta tatatgattc 2468221 aagcgcactg acgttgtgct caattttttc ttttttcttt tcacctgtta aaaaatatgg 2468281 atttttcaca atgacaagac gccgctcccc cataaacgga aacgtttcag catctgcaat 2468341 cgcttgatcc agcgggtcct cttccagatc aaaaacggac agattgaaat cctttgtctc 2468401 ctgatcaacg accgtctgtc tgatcctgct gacggtttct tgcagcagat atgtctcttt 2468461 tccgtataaa caataaaccg gatggacctc tccttttttc aggcttttcc acacatcaaa 2468521 taccattgtt gtacgacttc ctctctttca tcatcccctt ctatcctaaa ttgagtttgc 2468581 aaaatagtaa agaggaagcc tgactgctgc ttccccattt atattaaacg cctgttcgca 2468641 agcccccggg acagcttgta aaaaggcgat aatcaccaga acagaaaacg ttaccttagc 2468701 ttctagattt ttcaaaacaa ttccattata cttaagtcag tcaggaggga taaagttgaa 2468761 tgattttgaa aaaaacgttc aaagcaaacg aaatgatgct gtagattcag ctgttggttt 2468821 tgttgtgtcc ttcggatttt tcgccttctt gtttgtcatg gcaacggtta ttcacctagt 2468881 tggttcataa cagcgactgc ccgggctgct gatttctcgg cagtcttttt tagttcgtct 2468941 ctgttatatc tgatgtatca tatggaggat agacagaaaa ggttccaact ctgtttttgt 2469001 atctatattg gatcgttccg ttttgatctg ttcgcagcac gcggatagaa tgtctctgta 2469061 atagttgcag aactttttga tgaggatgat ggtaccgatt gtttttcccg gctgagataa 2469121 tggccgtttt cggctgaagc tgttggatga attcttcacc ggtagagcct ttgctcccat 2469181 ggtgccccac ctttaacaca tctgctttta tattcggaaa cacgttcatc acctcttgtt 2469241 ccccttcttt ctccagatca cccgtcaaga tccagctcat accgcccgtc tccatccaca 2469301 gaacgagaga tgaattattt ttgcttgccg gatcaggtgc ttccggtgac agtacatgga 2469361 actgcaaatc ctttatttgc aacacatcgc ctcgcttcac ctcttcaatt gccactccct 2469421 cttccctggc tgcctgcagc actttctcat ctttaggttc agaaacgaac cctttcggaa 2469481 tcacgaggcg ctttacttta tgatgcttca gcagaatctc cgcctctccg atatgatctt 2469541 ggtcagcgtg cgtcagaatt aaagcgtcaa gctgcttgat tcccttagca gttaaaaacg 2469601 gaatcagcac cttttccccc agtgaaaacg gatgctgttt ttcgcgccaa ggctctgacg 2469661 agtaagacaa agtgccgccg gtatcaatta agacacgacc ccgctgatgc ggagcaccta 2469721 caaacatgct gtcaccctgt ccaatatcta tcatatccac ttctccttcg gaactaagac 2469781 acggatatat aaagagcaga aacatcaccg tgcagcaaat gcctccggtt accatcaact 2469841 gcgacaagga gcgtttttca atcgccataa gcaataggat gatcgtgact gtgaataaaa 2469901 aaagcaaaac aggtgcagga tgtgcgatca taatcgtgaa cacatcaaca tctgcaatgt 2469961 ttgtgattaa cctattgatc cagcttatca ataaatcaaa ccagctgaaa aacaatctcc 2470021 caaacgaagc ggaaagactt aatagaagaa cacctgctac agctcccggc aaaatacaga 2470081 aggtataaaa tggtaccatc aacatattca tcggtacgct gatgatagaa aactgatgaa 2470141 aatgatatag gagaatcgga agcgagccca gctgagcgat gagtgataca attgtcagct 2470201 gccccaagga ggttttaacc tgctgaaaaa tagaagagga tagaattaaa gaaaaactga 2470261 cggcgaacga tagctgaaaa ccggcttcaa agagatgata aggattgaag agcagaagga 2470321 cgatgtacga aaggcaaatt gcagttgcag agcggacacg ccatttgaca agacttccag 2470381 ctaagtaaac acccgacatg agagcggcgc gtagcactga aggagcagcg ccggtcaaca 2470441 tcacatagag cggcagaaat aacagcaaca gaattgacgc cttttctcta gttataccaa 2470501 ggcggatcat gatataaaac aaacctgctg tcaaaatccc cacgtggagt cctgatattg 2470561 ccaagagatg gacaacacca agcttttgat acgcggtaag cacttcatcc tccacgtaaa 2470621 atctgtcacc aactgtaagt gcctgtacaa tccctgtcga atcaggaggc agaaggctgt 2470681 ttgtgaatga tatgatatgt tttctcaagc tgagcacctt gtacttgaaa ttttcaggtt 2470741 cgctgcagtt ttggatagac gtgacagagt agttccaatg aatatgctgc cgataaagat 2470801 actcgttata atcaaatgca cccggcacag ttgcgtgatt cggttcttcc aatgtaccag 2470861 tcaactcaca tgacattcct ggttctatgt ataacagctg ttctttttca ccagcagact 2470921 gaatgcgata cgcagcagcc catttttcct tatcaggtgt ctcaaccatc atagacatac 2470981 ggtcgccgtc aattttggga atagtgtcaa tcactgcctt gaattgatag gttccctgcc 2471041 gataggaaga gacattctga gaatctgtga ctgcatacag tacaaaaaac aatataaaag 2471101 agaagaaaca aacaataata agaaaagcgt gcctcgtttt gattaaaatg atgaggagaa 2471161 agaggatgaa aagaaaaata gcggggaaat aagcggcggc agtaattcca gccgttgccg 2471221 aagctgccgc cataggcaat aataagcgcg aattacgcat tcatcacacg tagctcgtga 2471281 aaagtgtatt cgcctgttca tgtatctttt tcaattcttc ctccgctaaa ccggcatcag 2471341 ccaatttccc tattagaccc gctacaaatg aaagcttttc tctgtttttc agatcaacga 2471401 tcatttcatc gagttcaacc tgttcaacag ttacacccgc ctgttcaaat aattcctgcg 2471461 catacggatg tgttttgtaa tcctcagcat aataaaccgt tttgatacca gcttgaataa 2471521 tagatttgca gcattgaatg cacggataat gcgtcacata aatctcggct ccatcagtcg 2471581 gcaccccaaa cttagagcat tgaagaatcg cattcatttc agcgtgaatg gttcttgcgc 2471641 aatgatcatc tatcattaag catccttcat ctgcacaatg tacgccgccc gcgattgacc 2471701 cattgtagcc tcctgctatc atgcgtttgt ctctgactat agtagcgccg acagataatc 2471761 tcggacatgt gctgcgcagc gccaataaat ggctttgagc cataaagtat tgattccatg 2471821 aaattcgttc cacgttgttc cctccaaatg ttgtgttgcc tgacctttag tttacctatc 2471881 ataatgcatg accgtcaaat cactttactg taatggaaga ctttattttc tcaaatgact 2471941 tttcacctat tcctgaaacc ttagtgatat cttcaattgt ttggaaacga ccgttttcct 2472001 cccggtatgc aataatagct tcagctttgg atggccccac ccctgagatg ccttgtaact 2472061 cctctaaggt tgctgtattg atattcacca gcgctccctt ccctccatcg ctttggacag 2472121 accctccgcc accttgctgc actgctgttt cctctccctt tttcgggatg tacaccactg 2472181 tcccgtcctg cagaatctcc gccaaattta cttgcgcttc gtctgcttgt tcactggtcc 2472241 cgcccgcttt ctcaattgcc tgagatactc tgtcccctgt tcgcatttca taaacgccag 2472301 gatgctgaac agcacctttg atgtctatca caattgtttc gtttgactcg tcgttgtttg 2472361 cttcctgctt taccactgta ttttctgtct ctgttggtac agcttgcttc accggctctt 2472421 tatttttccc tgtggccaga aagatcataa tcgctgtgaa aacagccgca gaagccgcta 2472481 aaataattgc tttcttatgc tgattcaacc aattcatcgt gcatgttccc cgctttcgtc 2472541 atattttatt ttcataacac atatggttta gaggataata gctcaaagga ggggaaacca 2472601 ttgaagatag gctttatcgg cacaggaaat atgggtacga tccttatcga atcatttatt 2472661 gaatcaaaag cggccgatcc ctcaaacatg acaatcacaa accgcacaat tgaaaaagcg 2472721 ttgcacataa aaaaccgcta caacagcata aacgttaccg aaagtctcga aaagctcgtt 2472781 tctgaaaacg agatgatttt tatttgtgtt aagccgcttg atatatatcc tttactggca 2472841 agagcgttac cttatttaag aaaagatcat attctcattt caattacaag ccccgttcaa 2472901 accgaacagc tcgaacaata tgtgccgtgt caagtggcgc gagtgatccc aagtattacg 2472961 aacagagcgc tggcaggtgt ttctctcgtc actttcggca caagctgcgg cgaatctgca 2473021 aaagcgaaaa tcaatgagct gatgcagcat atctctcatc cgctgcaaat tgaaagtgac 2473081 atcacgaggg ttgcatcaga catcgtaagc tgcggccccg cttttatgag ctatctgatt 2473141 cagcggttta tagatgcagc tgtttcggaa acatcagtgt ctaaacagga cgcgattttg 2473201 atgtgtaagg aaatgcttgt cggaatggga aaactgttag aaaccgaatt gtataccctg 2473261 cctgcattac aggaaaaggt ttgcgttaaa ggcggtgtaa caggagaagg cattaaagcg 2473321 ctggaaagcg gtgtgcagga tatgtttcac cgggtatttc aaaatactca tatgaagtac 2473381 gaggaggata tttccgcagt gaaaaagcag tttcatgtgt agacgagtat gtcatacgtt 2473441 cgtctgtact gcaaaagcat aaaaaagcat tttaaaaaac catcgtttta ggaaacgatg 2473501 gtttttgatt tctgcgcctt gaaaaagagg cgttctgatt gtgctgatgg ctcggtatcc 2473561 gtaaaatcag ctgtcacgcg atggagctga aagccgcagt tcttaagcat ttcttcgtat 2473621 tcttccaccg ggaacgttct ttgctcgtgt gtctcatcaa aacgatcata cgcttctccg 2473681 ttccacacaa aaaacgacat atcatgaatg acagaaagct cgtcacttcc ggcaaagctc 2473741 tgccaaatat agctgatatc ttcgtcctgg tcagcaaatg tgctatccgg aaagacttcc 2473801 gcaattttaa aagatgaatg aacatcaaac agcaggatgc cttcaggctt taatacccga 2473861 aaaacacttt taaaggtttc gatcacatca ttttttgttt ttaaataatt taatgagtca 2473921 cagcatatca caacagcgtc aaattgaccg tcaaagccgg taatctctct catatcctgc 2473981 tgaagaaata aaataggctg gctactcgat accttttgct gggcgaaaga aagcatctct 2474041 tcgctgagat cgatgcctgt aacctcgaag cctttttcgg caagccggat ggagatttcc 2474101 cccgtgccgc atgccagatc gagaatacgg cctttttccg ggagagatgc ttcaatccat 2474161 tttgtccatt gatcgtaagg cgcgtgtgac attagctcgt catacacgct tgcaaagcct 2474221 tgataaatca ttgattcatt ccaaagtcaa gatctgcgag cggagcgtct ccccacagct 2474281 tttcaaggtt gtagtagctt ctttcatcct tgtggaagac atggacaact acatcgccta 2474341 gatcaacgag aacccatctt gcttcatcaa agccttccat ctttttgact tgaatgccgt 2474401 tttcatcagc ttgatccttg atttcacggg caatcgcctg tacctgttta tctgaatttc 2474461 cgtggcagat cagaaaataa tcagcaacca gagaaatacc ttccatatcc agtgctaaaa 2474521 tatcctctgc ccgtttatca tcgcaagccg cagctgcgat ctttaaaatg gacttttggt 2474581 tcattcacaa attcctcctg ttcagctgcc agacacaagc cagttatacg ttaaaaatgt 2474641 gtctggaaaa accggttgat tttttttcat aagaaaaacc attgtatttt taatggactg 2474701 aatcagcgct tgattcaaat ctgtctcagc aagcttacgc acctcatcga caccgggaaa 2474761 tgcccggttt ggctcaatgt aatcggcaac gtaaatgact ttttctaaaa gtgtcatgcc 2474821 ggggcggcct gaggtatgat acctaatggc gtcaagaatg tcttcatctt gaacccctgc 2474881 ctctctttgg accaaataag cgccgaccgg agcgtgccag agctccggat tatgatccaa 2474941 taaatgcgca ggcatttttt cacgcgcaat aatttgtttc atttcttctt tcgggcggaa 2475001 tttggcgtaa tcatgaaaga ttgccgctat ttccgctttt ttagaatcgg ctccaaaacg 2475061 ctccgcaagt tcgatcgccg tgttcatcac gccaaccgta tggatatatc ggtgttcggt 2475121 caattgctgc ttcacgcatg caagtgcctc ctcacgattc atataaacca ttctcctcta 2475181 catacttctt cactttatca gggattaagt agtcagtggg cttcttgctt ttaaaccgtt 2475241 cccttatcat agttgatgat acctcaaatt ccggaacgtc tgcaaagaga agcggataag 2475301 gggtttcaac atgaaaaccg gggcgcttta ctccaataaa ttgaatgagg ttcagcagct 2475361 cgtccagctt ataccatttc ggcaaatatt caatcatatc agcgccgata ataaagaaca 2475421 gctgatcatt tggataacgc tgcttcagta aagaaacggt atcaaaggta tatgatggcc 2475481 cttctctttc catttcaaca agctccagct taaaggacgg attagattga attgcaagct 2475541 ttagcatttc cacgcgatga aagctgtcgg tatagtcttc gttctgttta tgcggcggaa 2475601 tttgattagg cataaaccaa atttcatcaa gccccgcctg gtacagcacc tcattcgcca 2475661 ttaagaggtg accattatgc ggagggtcaa acgtgcctcc gaaaattccg attttcttca 2475721 tttcaaccac ctttaaggaa gctcgatttg tttattttcc tttgattcct tatataacac 2475781 aatcgtattg ccgattgtct gcaccaattg agagcggctt ccttttacaa gagcttccgc 2475841 tacatcgttt ttatcctctt cgcaattctg aagcacgctg actttaatca gctctctcgc 2475901 ttcaagcgcc tcagcaattt gtttaatcat gttgtcgttt actccgcctt tacctacttg 2475961 aaaaatcggc gttaaatgat gcgcttttga acgcaaaaaa cgtttttgtt tacctgttaa 2476021 cattctgttc ctcctaattt tcctattaca atagatctca ttttttcaat attaggctct 2476081 tgtccagtcc acaattggaa agacaatgct gcctgttcaa caaacatgcc cacaccatcg 2476141 agtgttttca agcctttttg gcttgcttct tttaaaagtg ccgtctgtat tggattatac 2476201 acgatatcac atacgacggc actgctcgcg gcacgctgta atgaaagcgg cacatcgtcc 2476261 acgttcggat acatgcccac agacgttgta tggatgataa catcatactg ctcaagacgt 2476321 tcttctgctt cttttatgct taatacttct ttattgtgaa acgagggagt agcttctgta 2476381 agccgctttg ctttttctaa cgtccggttg caaatgtcaa attttttcgg ggtatttcgg 2476441 acaattgttg taaaaatggc tctcgccgct ccgccagcgc cgatcattaa gaatgacagt 2476501 tcagagatgg gcttgtctaa taccttcatt aatgacttca cgaagccttc cccatcggta 2476561 ttgtatccga caagcttatc tccctctctt ctgaccgtgt ttacggcacc gagcactttt 2476621 gcactctcat caatatgatc caaataatcc ataatggaaa ccttgtgcgg aacagtcaca 2476681 ttgattcctt gtacgcctag agctcttatt ccttttaccg catcctccag atcattctct 2476741 tctaccttga aggcatgata atgtccgtca agcccgaggt ctttcaatga tgcgttatga 2476801 atatcaggtg acatagaatg gccaatagga tttccgataa ccccgtacag ctttttcata 2476861 cacctctccc cttttcttaa attaatgaac gccgaacaaa tacatgaacg ccttttggcg 2476921 cgtatgcagt taccttttta tcagcgtcat ggacagtaac ccagcctaac ccagagaaaa 2476981 cgatatctgt ctttttgtct tttatcgtaa acgtatgggc gaccaattca ggaaactcat 2477041 ccatttcatc tttacccgga ggtgtgagca attcccctgc atgcttttca taaagcgcgt 2477101 ctgcattttc aagttttgtt ctatgaatca tcagctcatt cggcatatag caaataaaag 2477161 gagatctttc cccagacaca taatcaaacc ttgcaagtcc gccaaaatac agtgtttgct 2477221 gatcattaag ctggaatgtg cgaggcttca gctccttttt aggagataat attttcaggt 2477281 cctttttatt gacataatgc gccatttgat ggttgttgat aattcccggt gtatcataaa 2477341 gcgatgaacc gtcatccagc gggatttcaa tcgcatcaag ggttgtgcca ggaaattggg 2477401 atgttgtaat aatatcttct tcacctgaca cttctttaat aatccggtta ataaaggttg 2477461 actttcctac atttgtacat ccgacaacat agacgtcttt tccgttgcgg taatgctcaa 2477521 tcgcgtcaat tacttctctg attccctggc cgcgacccgc actgaccaaa aatacgtcaa 2477581 ccggttttaa gccaagctct ttcgcttcac gcttcatcca ttggatcaga cgctctcttt 2477641 tcagtgactt aggcaaaata tccgctttat tgccaactaa taagataggg tttcccccca 2477701 ccaagcgctg cagcccatta atccagctgc cgttaaaatc aaaaatatca acaattttta 2477761 cgaccagaga gtccgtttct ccaataccgt gaagaatgtt caaaaaatca tcatcagtta 2477821 aggagacatc ttgtatttca ttatagtttt tcagtctgaa gcaacgctgg caaatcacat 2477881 tttctttcgt aagcgatgca ggcggcgcgt accccaaacc tgttttgtcc tcggtttgga 2477941 tcgtaactcc gcacccgata caaacaacct tttccatttc ttactcctcc cactgaatgt 2478001 gcccttttcg tttgagagca ctcagtattc tgcgttcgac ctggcggtta aagcgcgtaa 2478061 tgaatccgtc agaggaagcg actggcacga ccaaaatcgt atggtagccg tttcggtttc 2478121 ccccgagtac atcggtcagc agctggtctc cgatgacaac gcagtcctct tttttcagct 2478181 ccatattgcg caccgctcta ttaaaggctt tacccatcgg ttttcttgct ttatagatga 2478241 atgggattcc aagcggttct gagaaaagtt tcactcttct ttcgttatta ttagagacaa 2478301 ttgtcacttt aatgccgtgt tccttcattt cttcaaacca ctcgatcaat cgcggcgtcg 2478361 cgttcggcct gtcccattca acaagcgtat tatccaggtc agtaataatt ccttttacat 2478421 ttcgttcctt taatttctca ggtgtaatat gaaaaatatt ttttacaaac tcgtcaggta 2478481 aaaaaaactt ttttaacaaa acccgcaccc ttcccttttt ctttctttca aaatgattgt 2478541 cgaaaaaaat cgaacttgcg cctaaagaaa aactgagcaa aaaaatttcg acaaaaattg 2478601 ggtttcttca ccaggtgtgg ataaatttac acacactatc cactcttatt acatcactct 2478661 ttagacaaat tataaacacg atactcacaa gttatccact ttttggtgtg gataacagaa 2478721 cgattgttct tatatgcatt tcatggtaga ttaaagataa cttcaacctc agatgaatgc 2478781 aacttatcat tgtatgcgtt aaaatcatga atgattccaa cttttaagga ggtgcctctc 2478841 ccattaattg ggttcctagc atgagaaaac tgtctgatga attactaata gaatcttatt 2478901 tcaaagccac cgaaatgaat ttaaaccgtg actttattga gttaattgaa aacgaaataa 2478961 aaagaagatc gctcggacat attatttccg tatcttctta ataggaattt gtctattttt 2479021 tccgggcgta tttccttttt ttactcagat gactgatatt atatcacttt ggctgcgcgc 2479081 tttactacta ttttcagcaa aaaacacccc taaaaagagg tgttttaaag ggccggttat 2479141 tatgctaacc agtatatgcc gcccacaaca aggagaacaa caactaaaac aacaataaaa 2479201 gcgtatccat atgctctgcc tgcgccatac atgtgaagcg cctccttaat aaggttttat 2479261 aacagcctat gtaggagaaa taaatcggac taggcggttg tccggctcaa cgctgcagga 2479321 tctgcccatc ttgtattcct tcatatacga tccttgcccc tttaggtgtc atatgatttc 2479381 cagaaggatc tataagacca gattggataa gcgcttcatc agttgctttt ccgccgtctg 2479441 cttctataaa atgcttccag ttatctacaa gagggacatc caggcgcttc gacacatctc 2479501 ttgtaatatc gttatatgag ttgtgccatt tccttgctcc gccttttggt tcaaaagcag 2479561 ctgcttgata tctggaatag taaaacaaat gatgcttccc attaccttct ataattggga 2479621 tacacgtcat taagattggc ttgatcccgt gttttctgct ttcttcaata aaataaacca 2479681 gattttctct aaaacgctgc ttcgacactc tcggtttccc ctcagtcagt atggcagcgt 2479741 cattggttcc gaacataata aacaaatact tcggtttttg atccagcaca tctgtctgaa 2479801 atcggagacg ggcatcctct gtcgtctgtc cgccgattcc cgcattgagt atatcaaggt 2479861 taccgcgctc agctgttttt aatatattga cccactgctg tgcttttgga taatcgcgat 2479921 aatcccaatt agagccacgc gtattactgt caccaaatgc tacaacgtct tcgtatcccc 2479981 ttccctcgca tcctgctgta acgaacagca gaaggaaaag gatgataaaa tgtttcatct 2480041 ttacaccccc aaaagcctca ctttaatgtt atacctctgt ttctcttcgt tcaatgaaga 2480101 gtttttcgct atcactgttt tttcctatag ttaacgtgtc cccctcagtg aatatcattc 2480161 tgctttcatt gcggcgcagc tgatgatttt ttaaaattcc cttctttcca atctgaaaaa 2480221 cacacaaacc aaagaaaaga aaataacctg aatccgcact ggaaacaggt tatccgttaa 2480281 atcctgcatt tactttaact tcgatttaag cttggccttt gtttttggcc cataaatccc 2480341 gtctgcagtt aatccgttca tgagttgaaa acgcttgacg gcattcgctg ttttcggtcc 2480401 gtaaactcca tctatgccat tgtttttggc tcccttatca gggtaaaagt gaagtacagc 2480461 taaagccttt tgcagctgga gaatgtttgt gccctttcga taaggcgaag tgagctttat 2480521 aaccccagac ggcagaggat atgatggtga agtttctttt ggaggtgtat ccgaggaaga 2480581 aattccgttt agaaaagagt tccagtggtc caagagtttc cgcggacatt ctttcccgga 2480641 ccactttttg tggggaacaa cacgatttaa cggaatattg ttttccttca tcagctttct 2480701 gatcagccac tgggcatttg atgttgcttt ttcaaaatcg ccgtcagcat tttcacagat 2480761 ttcaatcccg atcgatttgc ggtttcctgt cccgtttgta ccgtctcccg catgccagcc 2480821 gttttcatct atcgggagat gctgataaat gactgaatcg tcaactgtaa aatgccagct 2480881 ttcggatgtg ttcgggtttt tcacaaactt ggcgtgcatt ttcgcatcag cgcctttggc 2480941 tgtattcgct gtattatgca ccgtaatata agcaggcgcc atcgcatagc caggacgatt 2481001 atcatttgat accggtataa aatccttttt tatggttacc atttctatcc ctccctatta 2481061 ataagaatgc agaaaacaga gagatggaca gcctttttta tgaggtaaaa aagaattgtg 2481121 ttcttaacct ggttttcagt tgaacagctg aaatggcacc agttatacta atttagatga 2481181 cggaggtttt gactcctgac atcacctaag ttgggagtga ccatagacat gttaaaaaaa 2481241 gtaataggta tacttgtgat tatcgctatc atttcagttg gtttttttca gaaagaagct 2481301 tggcttgatg caatcaaagc aggagggatg ttttccgttt tatttagtat gctgctgatt 2481361 gctgccgatg tttttttccc aatagtgccg tttgctttga ttgctgcttt aaatggcgca 2481421 gtgttcggga ctgcaaatgg aatttggatt acactgaccg gctcaatgct tggtacaata 2481481 ttgctgtttt ttctcgccag gtacagtttt agagattggg ccagaaaaaa agttcaggcc 2481541 tatcctgcca tacaaagcta cgaggcttcc ttcaacaaaa acgcttttac cgctgtttta 2481601 ttaggaaggc tgatacctgt cataccttca cttgtaatga acgtgatctg cgggctgagc 2481661 caggttcgct ggcatgtttt tttctttgcg tctttaatag ggaaaatccc caatattgtt 2481721 gttgtcacta ttgcaggtgc caatttcacc agcaataaat tattgtctat cagcatttac 2481781 ggtacatata ttctgatcat catgctggtc atttataaaa agttccctca tcttctgaag 2481841 gtgccaaaaa aataaggagg cttgttggcc cccttacttt ttttctgtcg catggcctcc 2481901 aaattcattt cgaagcgcag caaccacctt tcctgtaaac gtatcgtctg ttaaagaacg 2481961 gtatctcatc attagtgaca tggcgatgac cggcgttgcc gtctgcagat caagcgcggt 2482021 ttccaccgtc cattttcctt cacctgagga atgcataatg cccttgatct gatccagttt 2482081 cgcatcctta gcgaaagctc gctcagtcag tcccataagc caagaacgaa tgacagaacc 2482141 atgattccac actctggcaa ccttctcgta gtcaaaatca aattggctgt tttcaagcac 2482201 ttcgaatcct tcaccaatcg cggccatcat tccatactca attccattat ggatcatttt 2482261 taaaaaatgt ccgcttcccg cttcaccagc gtatagataa ccattttcga cggcagtatc 2482321 acgaaaaagc ggttccacaa tctcccatgc ttcatgatcg ccccccacca taaaacaggc 2482381 tccatgccgt gcgccttcca ttccgcccga cgttccggca tcgagataat ggatacccgc 2482441 ttctttcatt tgattgtagc ggcgaattga ttctttataa tgagagtttc cagcttcgat 2482501 aatcatatcg cctttactta ataaaggtga tacatcacgc aaaacagcat cgacaatgcc 2482561 atgcggtacc ataacccata ggatgcgcgg cgggtgtaat aaagaaatga actctttaag 2482621 atttgttgtc ccctcagccc cgtatgcttt cagttcatca acagccgctt gatttacatc 2482681 atatccaacc acttgatgat tgcggtcaat gaattgcttt cctatgttta tgcccatttt 2482741 ccctaagccg attaatccga ttttcatatc tgttcctcct gattgtctaa aaagccttta 2482801 ctctttatgt tccctatgga ttgtattgtg atacgcagaa aacaaatggg gcttacatcg 2482861 tctgcgcatg taaattttat ttttcatgac cgacggcgcc tgccagttct attactgaat 2482921 ctctttatat ccataattat cgctttatcc ttgatttacc atcagtttaa gttaaaatat 2482981 gggaaggaat tcgatttttt cagtaaaaag aaggtgacat gttgcagaat caatctcata 2483041 ctcttattgg agttacgaaa accgctgtat tctttttata cgctgcactt gcaatcatcg 2483101 gttttgcaat cgggtatttt attccgcaga ttgcgaaatg ggcattatcc ctcccctgga 2483161 tccctcttga aggaccactt cggctcatta cctcttttca gggatctaca gcttcattta 2483221 tcactgctct tctcggtatg tgtgcgggga tttggttcgc tcattctgtt attgcaatgc 2483281 tgctgtctgt caaaattaca gatcacacag tggaattcat caaaggaaaa aaagtgcaaa 2483341 caattcattc cgatgacatc gctcttgtat ttatggatca caaacggctt gtcctcctgg 2483401 gaacagccgg atatgaattg gtacgggaag aaattgatga aaaaccagta aacgttgaga 2483461 aggcctttag acagcatcat tacgaatggg caacagatgg tgatccgttt aaagatcaat 2483521 ttcgccgatg gattcctgat gcaccagacc tatcgcaagg cgcccatgcc ttattaaaag 2483581 ctcgtcacaa agcactgcag gacgaagaaa aagacgatat tgaagaattc cgtctcgaac 2483641 tggcacagct gggcatcgtt gtacgggacg aaggcacacg ccaatattgg cgaaaagcag 2483701 aaacctatcc cccgaaaatt cagctcggcg aaggattgta acaacagagg ctcaagaaag 2483761 agcctcttct ttactactgc acaataaaca gcactctggt accgtcagga tagctgctca 2483821 tttgattccc tacccacgag ccggcgccgc gattatcaga aggcgtcaca tatcggacat 2483881 cagcccctgc accgccttcc tcgcagaccg ccatcggcca ctcatcccgg tcatagcccg 2483941 gcttggtcgg gattcccttt aaagattcct cccgcctttt gtctgctcca tctctgtcaa 2484001 tggtacaaat atctggatgt ccctctgcaa tcgcatccct aatatgactg ccggtttccg 2484061 gataacgaga cagcggaaaa tataacactt tgtcatacga agatgcgcct tggatctgtt 2484121 gcggaaccat taaacaaaga agaactgctg cagcaagaaa caggcctgcc atccattttt 2484181 tcatccccat ccccccatac ctttgttcat ttcaatgtat gggcgcttga tgaagaatat 2484241 ttttaacatt tgaagttagt atgctgctta ccaaagccgg actcccccgc gagaaatttc 2484301 ccggtacaga cacagacagc ctcccggtca catacattta catataggct tttgcctaca 2484361 tacttttgtg gaggtgacga tggtgacagg tgttttcgca gcgctcggct ttgttgttaa 2484421 agagcttgtc tttttagtat cttacgtgaa aaacaatgcc tttccacaac cgctctcaag 2484481 cagcgaagaa aaaaaatact tagagctcat ggctaaaggg gatgaacatg ccagaaacat 2484541 gctgattgag cataatcttc gcttggtcgc ccatattgtg aaaaagttcg aaaatacagg 2484601 tgaggatgca gaggacttaa tctccatcgg aacgatcggg cttattaaag gaattgaaag 2484661 ctattccgct ggaaaaggga caaagctggc gacgtatgca gcgaggtgta ttgaaaatga 2484721 gattgtaatt acaaaagggg ggtgcataca cccctcttta atacgtttca atatatatgg 2484781 tgtcagaatc cacaatggta acttctttca cgataaagtt aacaattgtt tttttatctt 2484841 caagagttaa gttatctgca ccgattgatt gaaaatagtc gatggctctt tttagagcat 2484901 tttcacttga gctcgtatca tctaggactt tcatttttga ctggatttcg ttacactttt 2484961 cagtaagctg attttgcttt ttttgcagtt caataatttg tgctttgatt tcatctatgt 2485021 ctaaatcatc gtcatcgctt aggctgatta gcgttaaaag acgcttgcgg cctttttttg 2485081 ttttctctat ctctttttca ataagttcta attcatcaga caggtgattt gattgttcag 2485141 cctctttaaa agaaacatac ttttgaggat ttgtgatgaa tttaaaaatt tcaccccata 2485201 catgccggtt caatttattc tcagacattt cttttccgca gccgcggtcc tttgcgccag 2485261 aataattttt ccggcaagta tatacatagt agtctttacc atgtgatttt cttttcttcc 2485321 ctgtcatggt atttccgcat tttccgcatc taaccaaacc cgataacaag taattgtgag 2485381 ggctgatact caagtgtttt cttttacttt gacctaagag ttcttgagca taatcccatt 2485441 gttcagctgg aacaattgct ggaattgtca cagtgatttg ttcttcttca ggccttattt 2485501 taattataga tttgttccct gcctgctttg aaacatagga accctctgta tcatatttat 2485561 actgtctatg ttcaccctta taggaagagt tcattaatat ttgccgaaca acctgcctgt 2485621 gccatacttt ggcgcctttt tttgttttaa cccccatctg agttaaatgt agagcaatac 2485681 catttactct gccgaaaaaa gggcttttat gatcggtgaa atagttaaaa atcatccgaa 2485741 tgatttttgc ttcctcttct aatatctcaa gagttctttt ctctttaaca aatttatagc 2485801 catatagttt agaatcttta atgatcatgc cttttttcat tttttgaagt cggccgcttg 2485861 atgtccgttc tttgattttg gctttttcaa attctgagat tgccccgcgc attgcgaaaa 2485921 acaattgacc ttctggagaa ttggcgtatt caccatttac aaaaatcaaa ggtatgtttc 2485981 gctttcgcaa ttcgtcatca atgattagct gattcattaa tttccgagaa agacggtcag 2486041 gatcgtaaca aatgacttga cttataagtc ccttgcttgc atcctccctc aagcgattca 2486101 aagccggacg ttctaaaagc tctcctgaaa atccttcatc tgcatacttc agcacatctt 2486161 tagtccctgc tttctttata caggcctcga tttggctgtc gatgctcgat cccttgatcg 2486221 cttgttcctc ggtcgatacc cttacatata ttgctatcac cctgaatctc cttcctataa 2486281 agttttatta aataatgata gcaatcgtta atgcatttgt cagcttgcgg tccctcgatg 2486341 attatcactt tcataaaatg catcacccct tgggtaatgc tatgtaacag ctgtttgtcc 2486401 aaatgaggag attttaaatt aaactatagt gttattaaac gtttcaatga atatgcaaaa 2486461 aatttaaaaa aagttgttgt gacttttcta cactccttta ggtcctcaat agaaaagatt 2486521 ttattttcta tgcctcaaca ttcgcttatt atagttttca atgatttatt attatttgag 2486581 agtacaatgg agtagtgttt ttcattgtta gatagttaat gacatttcac tggtgtcaag 2486641 ttcgtatagc tagacattaa taaaaaaagg acacatataa atatgcatcc tttaacaaaa 2486701 gagtttattt atttccctgt ttcagcaaat tccttcaacc tattccctat ttcatcacga 2486761 actctttgga aaaacgccca tttttcttct tctgtccctt gtgctcttgc cggatcatca 2486821 aaaccccaat gctcacgttt tacatgtgga ggcgtcatcg ggcatttatc agcagcatct 2486881 ccacaaagcg taacaactaa atcagcattg ttcagaatat cagaatcgat tatatctgac 2486941 gtttgattag agatatctat accaacttcc ttcatcgctt taacagcatt cggatttaat 2487001 ccatgtgctt ctatccccgc gctatacact ttccactcat cacctaaata ttgtttagcc 2487061 catccttcag ccatttggct ccggcaagag ttccctgtac ataaaaagta aatgatttta 2487121 ttctccatat attccacctc tacatcgagt gacttccaaa gtattttcgt tgaaaccata 2487181 aagcaacctt aacaagtgct atcatgactg gcacttctac aagcggacca attacggcgg 2487241 caaatgctgc acccgaatga attcgatatc aagcttcgca cttaaacaca gcggaattta 2487301 taatatatgc ttggacagcc gtaaaagccg aactgaacaa tggtatgatt ttgctcatga 2487361 attttgccat atatatagac atgaaggcga taaaaaaaca atgcctgcaa cttggactga 2487421 ttatttggat tggcagtcca attattttac atatcacttt tgcattccaa cttgcatgtt 2487481 gcgtaatatc aaccttccgt acatacaatc acatgcaatt gaaaatgtag cttggttatt 2487541 taaggtatcc ccttcattcg ctaagaaacg tttaagcatt tattacagga aactgactca 2487601 acatttattt agtcaaactg ttacgggaaa tttatgcccc ccctttttgt aatgaataat 2487661 gaaatcctca tgcatttgcg cgcattgaaa aaaacaaaaa aagacgtctc ccttcacgat 2487721 ccgatcgggc aggataagga agggaatgaa ataagcctga ttgacgtttt gaaatcagaa 2487781 aacgaagacg tgatagatac gatccagctc aatatggagc ttgaaaaagt gaaacaatac 2487841 attgacattt tagatgaccg tgagaaggaa gtgattgtcg ggcggtttgg acttgatttg 2487901 aagaaggaaa aaacgcagcg agagattgcc aaagaactcg gtatctcacg cagctatgta 2487961 tcgcggattg aaaagcgggc gctgatgaag atgtttcatg agttttatcg ggcagagaag 2488021 gaaaagcgga agaaggcgaa ggggaaataa tgcagaagaa gccggatctc atactccggc 2488081 tttctctatt tgaaagagtt atgaaaatca tttttttcat cgctgataag ctctccgaga 2488141 aagacaggca ggatcgtaac aaataacttg acttataatc ctcccgcagg cattcaaagc 2488201 cggacgttct aaaagctctc ctgagaaaat ccttagatcg gtatacttca gtacatcttt 2488261 agtccctgct ttctttatac aggcctcgat ctggctgtcg atgctcgatc ccttgatcgc 2488321 ttgttccacg atatattgct atcaccctgg atctcctgcc tataaagttt tattaaataa 2488381 tgatagcaat cgttcatgca tttgtcagtt tgcagtccct cgatgattat taccttcata 2488441 aaatacatca ccccttgggt aatgctgcgt aatacctgtt tgtcctaatg aggtgatttt 2488501 caatgagtat gaaaacaaat aaaaaaaccg atggtttgta ccatcgatct gttttctata 2488561 tcactaggcc ctcaatatag taaatctagc tcattggtta tgaaagctta ttttcattac 2488621 acactatata ttcatttgtt atcatttcta tacgtttata tcaattatgg taaaaaatgg 2488681 ttacaaaaac ccaataaacg tccaacctaa ctttttcatc ttatttatta agaattttaa 2488741 cctcttcctt gtgaaataaa gaagcgattt tcatctccaa acagttaatg ctatttcatc 2488801 gggacatgtc tgttaaagta gccaataaat acattcggat atccacttac aaccacgatt 2488861 caatttgatc cactacagat ttctgagctg acattaaaca gatagagtta taaaaatctg 2488921 taccagttcc ctttcacaat taggacattt cggcggcgtt tcggcataat gcgaactaat 2488981 ttattaatgt tcaacaacag aatttcgtct attggcaata aagaatccac aaatcattgc 2489041 aagaatggcc atcgcccacc agaacgttga gatcgcctga tcatgatcga tgataatcaa 2489101 acgaatgaca gctgtgatgc caatataaat gaagtagcga agcggaaaat gaaagtctga 2489161 tttgaagtat ttgataatca aagcaatgaa ctcaaagtac atgaagaata taagcagttc 2489221 tccaagcatc tcataatagc tgtccacttt gttgaacagt gacttgtata cgaatagcac 2489281 aatgtaccaa gtctcgctga tcagaagtgc gcttaaggct aacgccagaa agaacagaca 2489341 gacgttgaga agcgcttgta acaggtaagg cacctttttg aatttgttag aaaatctcat 2489401 catgttgtct cctatttcaa tatattcgtg gtttttattc tcagcctaca tcttggtgtt 2489461 ccaaaatcgt agcacaatgt agtacttaga attcttttgt atactgtgaa actgtccctg 2489521 catgcgggac atcattcgcg caatgcttct ttcaccgagt ccgttgcttt ccggtgttat 2489581 atctgcaagt ttaatcgtat tgctaacatg gatctcaaat atctcttgat ccgatacaaa 2489641 cgtgatactg attttttctt ccggatctgc gtatttcaat aagtttgaca tcacattatc 2489701 aaatacacga ccaagctcct ccaaattcac gttaatatag gtttccggca gctcgcctga 2489761 aatatggacc cgaaaatgct cctgatgaag gatagcaatc tgatctgata ttagatcgta 2489821 gatcacttct ttcactgcaa cggtctccag atcggcctca tattccttgt tcagcaggaa 2489881 atacgcaaac agattgtcag acaagctttt taattgcagt gctttaccat aagcattggc 2489941 tacataccga tctttgctgg cacccgcttc gcctccctct tttttggcaa actccagatt 2490001 catgatcagc gacgtcagcg gtgtgcgcat atcgtgcgac atttcggtaa ccaggctgcg 2490061 gctctcagct tgcaattcct cgatagcttt aagtttatcc aggaaagctt tccgcagatc 2490121 ctcaatgctc tttgcaatca tcgctaattc atcatgccct tttatcgtca tctcgtagtc 2490181 cagttcgccc ccttcaagaa tatgaatctc ttgatgaatc gttttaaggt agcgaagact 2490241 ttggcgaatt ccgaagagaa caatgattaa aaagatgagg gttgccccga gcaaatccaa 2490301 tgcaaaggcc agatcataat atcgggaaga gtagaaaccg tcgataatga ctcgtccttc 2490361 accatcgcta aacttgacag gatgtgaatg attttgagcg tactgagtca gcttttcctt 2490421 tccataatcc gattcggaat aaatagaatc atattgcagc tcctgatcct tgaatatggt 2490481 gaggttaatg taattttctt ttttgaccca ctcgccaaac gcttttctat ctgatgtaga 2490541 caactcattt tctgaaacgt acttgctgaa tttttgaatg tatcttgctg actcctcgtg 2490601 ataatactct tccgaactca gatatccctc gatcagatca tctgtgatct tttgcaacgt 2490661 cagaaagatc acaccactca caatcgcagc aaccattatc agcaaagcca gttttttggt 2490721 tagcgtaaat ttaagatgcg ccaaatcgat atcctcttcc ccattcagtt tttatataaa 2490781 ccggacgtgc cggatcatcc tcaattttgg agcgcagctt ccgtatatgc accatcaccg 2490841 tattgttgga acagtaaaag taaggctgtc cccacacact ctcatatata ttttgggcag 2490901 aaaatatttt gttgcgtttg ttcatcagaa gtttcaggat acgatactcc agatctgaca 2490961 acttgatttg cttctcctct ttccacacct cattaaattc ttcgctcact cttagtttgc 2491021 ccccgataag aaatgtttct tcctgttcct tcttttcctg atagatagta tatctgcgta 2491081 attgagcaat cactctagcg tgaagttcct cttccgagaa tggtttagtc atataatcat 2491141 cgccgccggc gagtaatccc tcagttttat cgagtgtact cgatctggcc gtcagaaaca 2491201 gaatcgggac gttagaggat ttcctgatgt gctgacatgt ttcaattccc gaaatgcctg 2491261 gcatcataat atccaaaata accaaatcaa gcgagtcatt cacaagttgc aatgctcgct 2491321 ttccatcctt ggctcttagc acctcgtaac ctgcacgtgt aagggattcc tccaaaagat 2491381 caccaatatc ctcatcatcc tctacgacta atattcgata ggccatgtct ctctcacctc 2491441 atgattcttg ttgttatttc tcgtgtgtcc ttactatata tcgttcatag taataagtac 2491501 gttataagat actacgtaaa tcttaacaat ttatgaaagc tgatgctcgc cacaaatttg 2491561 tcacattttc taaaaaaaat gatgactctt cataaattgt taagattcgg tctttatatt 2491621 tatccattgt aaggctcaag tttttcagat ccgcactaca cattgccgtg ataaatggga 2491681 aaggagtatt gatatgattg tacaaaaaga aggacgcggg caaccggtga gtctgcggga 2491741 acgggttcat tttctggaca tcgtacgagg atttgccttg cttggcatta ttattgtcaa 2491801 ttattttctg atcgtagatt cagtaaaggg attcgaaatg gcctccgatg acgtactgca 2491861 taagctggtt tcctggtttg ccgaagggaa attcgttacg ttattctcct tcctgttcgg 2491921 agtcgggttt atgatcttta tggatcgagc cgcgcagaag gtagagagtc ccaacaagct 2491981 gtttgcccgc aggttatcta tcctgttggg atttggcatt ttgcacatca catttgtttg 2492041 ggtcggtgac atattggcct tttacgccgt aagtggcttc ctgttactcg ccttctataa 2492101 acgcacggcc aaaacggtgc ttagatggat tatcgcactt atcgtgtttc aattcctgac 2492161 tcctgttttc acaatgttgt acaatgtcat caatactgca gggtcaaaaa acccgaattt 2492221 ttcagagttt actttgttta gccacagcag ccttacctac atggaatcca tcagcactcg 2492281 gtggacagat atggtcacga tggctgccgg ctctttctct atgatctatt ccatgtttct 2492341 catgtttctg ctgggcgtgt actttgttaa gatggaattt ttcaaagaca tggaagcgaa 2492401 aaagcctata tggaagcgta tctggatcat tagcacaatc gcttttctaa taacacaaag 2492461 cagtatatta ctagacatgt ttaatctttc tgagaatatg ctgtggaagg acatttcctc 2492521 tgtcttgggt caaaatggcg gcttaaccgg aagtatgttt tatatgagca cttttgcaat 2492581 gctgtttcta taccttcctc agctgcgagg ccctatgatg atattcacca aagtcggacg 2492641 gatgtcattg acctgttatc tgcttcactc tatcattgga acagttctgt tcctcaggta 2492701 cggattcggg cttgcggatc atattcaatc cgccggcacg ttcatgttca gtctggccgt 2492761 gtacttcgtt cttatgagct ttagtacatt gtggttgaaa cggtttaggt acggtccgat 2492821 ggaattagta tggcgcaagc tgacgtacgg caaagtaaac gggagtccca aagcaactcc 2492881 gctgcattcg gaaaaatcta ttcagaaata acccccttgc acagattgca tgacttcaaa 2492941 ttagtgttgt tgaatgaagc gggcattaaa cggacagatt tgatatatgg actagttatt 2493001 tttatatcat ttaggcttct ttgggctaat aaatccacca gagtttactc aatgtgcatt 2493061 gctcatgatc gaatctaaat tgaatctttt acgcatgttc atagtcaaag gcgcctcatt 2493121 cgactatttt tgtaactttt cgcaggaaaa attcgagaat gatgacaaat cccgcatacg 2493181 acacttaata cggtagtgaa caatagtaaa ttagggttac atgcagcttg ttttccaatg 2493241 aaacaaagaa aaagaatcat acaaaaagac aggagaaagc ttttgaagta ttttaacgcc 2493301 aaatttaccg cggaagaaag agcgatggaa tcactttttt gtgaaaaggc ctcgcagagc 2493361 agctcgaatg ttttactgaa cgactgaact ctatatttta gcaactgagg gagtgaacaa 2493421 tcatgaaaac taaaaatgaa ccaaaagtta ttctggaact agcaaaggaa tctgatctgc 2493481 cagaattcca aaaaaaatta caagaagcct ttgcgatcgc cgtgattgaa acgttcggtg 2493541 attgcgaaga tgggccgatt ccatcggaca atgatgttca ggagtctttc aatgctcccg 2493601 gagcagtggt atatcatatt cttcaggatg gtaagaatgt cggtggtgca gtagtacgta 2493661 tcaacagcca aacaaatcat aattcgctag atttattcta tgtatctcca gaatatcaca 2493721 gccaagggat tggtctttct gcttggaaag ccattgaagc acagtatccg gatactgtgc 2493781 tttgggaaac cgtgacacct tatttcgaaa agcgaaatat caacttctat gtgaataagt 2493841 gtggatttca tatcgtagag ttctacaatg aacatcactc taatccgcat atgcatcgca 2493901 atggacgtga agatgacaag cccctactga atgatgatga ctttttcaga tttgtaaaga 2493961 ttatgaaaaa aaaggactaa acaattgaac acggcgagat gccgcagaga gttgctggta 2494021 acttttttat atttcattat cagaggaagg taataatgat gtttaaaagg tgttttgatc 2494081 cctgtctcat aaacaggggt caaaacacct ttgaatcatc ggtttctttt ctgacatata 2494141 ccacgcccac tagtccctca acatagtaaa aacatatcat gagttacaaa agcttttatt 2494201 caaagcatat gtttatttta tttatactta ttttcatcat ttttcagaat tctggacaca 2494261 aatcgggtac ctattagagg ccaaggaact ctacatttca ttaagaaata cgtactcatt 2494321 gccctgcttt aattaatttt aagccctcgc actatgcccc cccctgaatt aagtatttga 2494381 tgtaactttg aaattaagtt tatgaaaatc tgtcacaaac ccttatttca taacacatca 2494441 tttgtttcag cttccctcgc gaataccgga ttaatgctcg gctttaagat agtcaaccaa 2494501 tctctccgca ctgttcttaa catcttcttt tgaaagatga agtgtcccat attgtgtaaa 2494561 cgcaggaaga aaacgcattc ctatatagtt agcagtgact tgaaacggtc tgataagctc 2494621 gctgatcgtg atattatatt ctccgcctgc ttgataatca gattcctgtg cgcctaagga 2494681 gatagctaag agtagttctt ttccatgcaa tttagttcct ccagttccat aagcccagcc 2494741 atgtgttaac acatcatctt cccattgttt gagtaacgcg ggactgctgt accaatacat 2494801 tgggaactga aaaacgatac gctcatgatc taacaggagc tgctgctctt tttctacatc 2494861 aatgataaaa ttagggtatt caccgtacag gtcatgaacc gtaatgtctt tctcttgctt 2494921 taaacgattc atccaggttt tgttgacaac agacgtttcc aaattaggat gtataacgat 2494981 aactaatgtt ttcattagac tgattatcct ttctttgcca attagttatt attttttacg 2495041 ataatgaatt gattctaatt ttaaaatagc aactttattt acacctattt tatccttttt 2495101 catgaattca gggcaactaa ttgggcacca aaatcaatga tgacttaaga cattgttttg 2495161 tagaaatccg atatacagaa taatccatta tttagaaaat ttctaccttt tccctcaatc 2495221 cttaccaatt taaactcatt aaggagatac tttatcacca actttaaata ataatggaat 2495281 aagtgctaat aaaataattc ctacaaccaa cgtagatatt attaactcct tccatacaat 2495341 caaattcttt aaaaacattt gataaataac taatgagttt actggaatgt taagcaataa 2495401 gcccgtaaga agtccaggtg catacttttt cattacaaca gttgcgataa gatgtggaaa 2495461 aatagcgttg ataaccatag aacctagaaa gccaatgaaa atccattttg caatatctga 2495521 ttctggcata tataaaaaac caaatgcaga taaataagcc aacatagtta taacaatgac 2495581 agcaaaatga aattcatttg aagttactgg cttttgaaac tttgaagatt gttgtgacca 2495641 ctcaggtaac caaatagctt cctcaatatt atgaagtgta atagcaaaac aaaaaaatgc 2495701 tacgaaataa accacctatc atttcctcct cggtgccaca accaatatgg tttggcaaca 2495761 ttatattaca tttgaggctg attggatatg gtgttaaaag agagaagaat ctgccttagt 2495821 agttgcttct taattatatg tgcaataacg tgttgttacg tggcatgtca tattcaaata 2495881 taataactct aaagcaaaca aagataccta tatagtttgg catcctcttt tttagttcga 2495941 gtccctctat ttattttggg cacaaaatag acataattta tattgactca ttatacccat 2496001 cacataccat accccttaaa ccaatcagga ttaaaatgtt ttaaaaaagg tgatcaaaga 2496061 ttaagttatg gtctctttta ttttatgtat gctgtcttaa tgcaaaacaa cactggacac 2496121 cactaagtca aatgcatttc atggtactat agtcaagact tgtccaagtc accattatca 2496181 aaatgaattt catcaaacac ttgaaacatt tattgaacgc ggccaagtgt cataacatta 2496241 ataagaaacc aacgagtgat gaatctttta atctttcatt ttacccgctg gctcatatca 2496301 aaggagctct aaccaaattt taatagctgt cgcacctatt aattgcgcta aaacccattg 2496361 caggaatttt gtatttactt tttgcccaac tgatgcgcca ataggagaag ctattaaact 2496421 agtaatcata agaaccagag ctggtacaaa aagaacctgg cccgtgatta cttttccaac 2496481 tgttgcgcca atggatgaaa gaaatgtaat cgcaagagat gaagcgactg tgactctaac 2496541 aggaatattt aaaatcgata acataatggg gactaggata aaggcgccgc cagctcctaa 2496601 aatacctgat acgccaccaa tgataaacgc taaggaagaa gccaaccatt tattaaatat 2496661 cacttcctta tcttcgctat gttcttgtcc tttctgtcct tttttaggta taaacattaa 2496721 aataactgct ataatagcca gaattccgta tataaagtta attccttttt cagatatata 2496781 atgagaaaag taactcccca atacactccc taaaaggatg ctgcttccca tgtaaataat 2496841 taatgtttta tttataagac cactcttacg ataagcccaa acaccgccga gtgtcgcaaa 2496901 aaaaacttga atagccccta tccctgaaac ttcatgggca gttaatgaca tcactcccac 2496961 taaagaagga atgtacaata gcattggata attaataact gctccgccaa taccaatcat 2497021 tccggaaata aaggcaccaa taaaccctat aatgaaaaga gttgtgataa aggcaatatc 2497081 cattttattt gcctcctttc ataggaaaag ggtatctttc tattcgatac cctttcacat 2497141 tcattagcct ttttgaatcc aaaatttcaa tatatcgccc tcgtccgttt gctctaaaag 2497201 gtcatgtccg cctgatttag accaggctgt aagatcattt ttggctccct tatctgttgc 2497261 atgcacttct aatatttgac ctgattccag ttcattcatc gctttttttg ttctgacaat 2497321 tggcattggg catgccaagc cttttgcgtc taatacttta tctgatttca tgttcttctc 2497381 tcctcttttt agcagaaact tgtgttaccg tattgcacag cggtttgggc caatctccat 2497441 ttcacgctgt ttttcttcat ctgggctgat tttccccatg tttgtttctc gaatctcttg 2497501 gtatgcattt ggttgcggag gcaaatgatc tgttactagg tgtctaaatt ctgtttcatc 2497561 cgcaatgttc aaaccatggt tctcgctaaa taatgtactt agttgtttac caacacttcc 2497621 attctcattt agctcgtcaa tgatcataaa gtgtgccggt aatacaatta aatcctttga 2497681 taacgctttg taacggctat aaagcgtttt tcttaaatct cctacccaat cttctgccat 2497741 accggctaag tctggtctgc cgattgaatc aataaacaag atatcacctg aaagaagata 2497801 ctggtcatcg acaatgaaag aagtggagcc aatcgtgtgc cccggagaat aaatcggttg 2497861 aattttaatc gttgtatttc caataataat gtcatttcct tcttccaacg gctgataatc 2497921 gaattccact tcttcagcat ctttaggcgg taaccagtag gttgcttttg ttttttcagc 2497981 aatgactctg ccgcctgaaa tatggtccgc gtgaagatgt gtatcaaata cgtgagtaat 2498041 cgttgcaccc ttccccttcg caaaatctat aaagaaattc accatacgtg tcgcatcaat 2498101 aattgctgct tcaccattgg aaatgaccat gtatgacaag cagcctttac cgattcgaac 2498161 aaactgatac atctcaccgc catcttttaa atccccgact tttaccggct ctaaatgttc 2498221 gctccatgct ttcattccac ccttaaggta ggatacagaa tgacctgctt cagaaagcat 2498281 ttcggatacc atgacggatg aaccttcttt tgcgcaaacg accagcactt ctttatcaga 2498341 aggaattttc tccaagatat cttctacgcc atctaaaaga tcaaaataag gaacattcaa 2498401 atggtcaaag tcatgccctt ctatcttcca atcactaaaa tcattttcat tacgcacatc 2498461 caaaataaat aaaggttctt tgttaaagat ttttttgtca cttcttttgg ggtcattgcc 2498521 tttacggtca tgtttcaata cctcctatat caaatctttt agcgggacta aaacgttaag 2498581 gatacatcag catctttcgt aaaaccaaaa aaggtaacag ccccgcctac ttcgattcct 2498641 tccataaaat catcttttgt taaacccata acgtccatcg ttatttgaca accaaatcat 2498701 gcaactccca tttcaatcag ttaagaatag aaggcacatt tgcgttccta caaccttctg 2498761 cgacatgctc ttttccttgt cgcaatatta cagactttat aagcatcaaa cagaccgcta 2498821 tttgccgcaa taatcgctac tcttgtactc atctgttcat catgcttttt atttattcgg 2498881 ttttacctgt ccaatcccgc atacccggga caacattaat aaccttttta aaaccttgtt 2498941 ttttcatggt gcgggccgcc atttcactcc ttcttcccga atggcagata atataaattt 2499001 catcattttc gtttaattcg ttagcgcgct tttccacttc accaagaggg atatgcacaa 2499061 ctcctgggat atgagctttt tcatattcct ctatctctcg aacatctaaa atgttaagag 2499121 actcgtcact atctactttc tgtttgaaag cttctaatga aatctcagga attgaagatg 2499181 cattttctga tgaatgctct cctccttttc gaagaaaatg acgaagtatt tctccctctg 2499241 cttcagtacc cagatattca tggcctgtac tttttgccca tgcttccaga tctgctgtag 2499301 aacctttatc tgtcgcatga atttccaata cttcaccagc ttttaaatcc ttcattctct 2499361 tcttcgtttt tacgataggc attggacacg ccaaaccttt agcgtctagt acaatagttg 2499421 ctttcatcat tttttcctcc ttttcttata taggggtggg ggtatacaaa tatacaaaaa 2499481 gtttctcact gtaagttaac accatgtatt cataccccct tttatatttg tgatgttttt 2499541 aaatccttgt ttcttcaata tttttacttg cctttaaact tctcattccg cttagcaatg 2499601 agtaaatgag taacattaga taaataagtt gacactgcct tcctcagcat ctgccaaata 2499661 agctgctaca ccagcatagt caatatcatc taatagttct ttttcctgta aaccaagaag 2499721 atccattgtc atcgtacaag ctacgagctt taccccctgt tcttgagcca tctcaatcaa 2499781 ctgaggtaaa gtaagtacat tatgcttttt catcacattt ttaatcattt tagggcccat 2499841 acctgcaaag ttcattttag ataaacccat cttatcagca ccacgaggca tcatctttcc 2499901 aaacattttt tcaagaaatc cttttttcac tggaatcagc tcttctttac gtaaagcgtt 2499961 aaatccccaa aaagtatgga agatcgtcac ttcatgatcg taggcagctg caccatttgc 2500021 aataatatag gctgccattg ctttatcata atccccgcta aataaaacaa ttgttgtgcg 2500081 ttttgtttgt tctgtcatgt ttattctcct aactaattac ccctgcgggt atattaaagt 2500141 caaaaaattt tttcgaaaga tctgctttta ttcaactctt taaataccat agggggtata 2500201 atataacgca tataaaaatt cgtcaacctt aggttgatga atttttatcg gctctttacc 2500261 aataagtcga ctgcttcttt tactaaattt tgtgtgtctt cgcctttttc taaactttca 2500321 cgaacacaat gttcaaggtt tgtgctcaca attaaaccca tcgctcgatc gatcgcatta 2500381 cgggaagctg ctaattgggt cacaacctct ctacaatctt ttccttgttc catcatagtc 2500441 aatacacctt taatttgtcc ttcaatccgt cgtaagcggt ttttaatctt ttgatcatac 2500501 tccatatatc aatgaaatcc tttctttcat ttatttttac atttacatgt tgccagttca 2500561 taactgttta catggatacc tttgcgcttt agaaaacgca ctcctaaatt taattccacc 2500621 cggtcacgag ctattatgtg tattttatca cgtggaatct ctaaataaaa acgttttaga 2500681 tacgcatatg ggatgtttaa aataatatta tccgaaaaat tggctacatc gttataatga 2500741 cgaatatcta atattgtgat gtccatagcc tctaatttat ctttatggat acaagagatt 2500801 ccggttatag gataataacg tctatacgtt gcaatgataa tcacaaaaat aagcaggaat 2500861 gcaataacta aataattgat actatttaca ccaccttatt aactctttgt ttattcacaa 2500921 aacaataata tacccccata ggtatatagt caagtgtgaa agttactttc tttgagctga 2500981 tagattcatt tcgatatccg cggattgaaa aaatacttac attcgataat gccaattctg 2501041 ctaaaaggaa ctcgaataaa gcaataagcc gatttaattt taaatcggct ttatttatca 2501101 attacttaaa attagcacaa gacacgctgc ttggatatta aatggggttt cattagcatg 2501161 gtactggttc cccatgtttc atgctggatg tgactttaat tattctagaa ttctccagaa 2501221 tatctgtgct aatcttccgc agccactgca tctgctttgg tttcatgaac tgtaccaaat 2501281 ggatggttag gaggagcata aatggagtaa agttttaatg gcgtatttcc tgtattaatt 2501341 acgttgtgcc aagtgccggc agggacaaca atggcagaat catcatagac atttctttga 2501401 aagttcaaat gatctttgct ctttcccatt ttgacgatcc cacgcccctg ctcaatccgt 2501461 aagaactggt caacgttagg atggatttcc aaaccaatgt cttctccaat accaagactc 2501521 atcaaagtaa cttgaaaatg ctttcctgtc cataaagcag tacggaacgt attgttttgt 2501581 tttgtggctc tattgatatt tacaacaaat ggttttggtc cataatcctt caaaagaagg 2501641 tttctatctt catatgaaga gcgcaaatcg gcacctctgt gtactttctc catctcattt 2501701 ggaatagtcc aataaacaga tcttccatca ttatacatcg gcacagtcac ataataataa 2501761 cattgaggcg aaaaagggtt atagtacatt ttttgatccc cgcaattata aatttttgtg 2501821 atagtatcct atgcatttat taagggagtg tgctaaatca agaaaactca tattaaacac 2501881 aaaaatgaat gttcgatcac cgtttgattc atggatgaat aatttatcac cgaccttgta 2501941 atcgttttct agatgttgaa tttcactagc ctttgttaac aagacatcga atgacacctt 2502001 tatatgatgg attatcaaag gtcgacgatc ctaaatggct tttgaacatt tacatagcac 2502061 aacaacagag tatacggaat tctgttgttt gtccccccta tcccagctct tttagattta 2502121 tctctttgga tgcgccttga tggccagttt ttcagcagca tagaatttat cccctcctga 2502181 atcgttatag catatttcaa cgccgataga cttgcggttc ccagtgccgt ttgtaccgtc 2502241 tcctgtatgt gggctcgctt ttagtaaacc agtttatatt ctttttgggc acacaacaga 2502301 aacaattttc catatgaaaa tctcgtaatt ttacacctct ttaacttgaa ggaggatttt 2502361 tgcatatgta ttttcatacc cgtcaactac catctcatcc agcatatatt cctcatatgc 2502421 attttcccct atttgcattc catttctttc aatgaactca atgattctcc ggtacgcctc 2502481 ttcagtattt ccgcctattt catatccaac tgcatacagg ccttttggcc gtacatgata 2502541 atttatgttc tctgccccat cttttacttt tatataaaag taactgtaat tgtagaagtc 2502601 tttttctaag atttgttccc gtgcaaagat tccgcctatc ggatatcctt catctaattc 2502661 atattgctga acttcatgaa tgagttctga aatggctgcc acatattttc gttctggtaa 2502721 gtttaatgtt tttcggctta acatgaatgt ttcttcattt aaatattcaa aagaaattga 2502781 ggaaaaatca gtctcaagtg cttgttctgt aagcgtcact tttgtttgta agatcgtttg 2502841 caactgctta agctcattta tttttttatc aatctcaata gacttttctt ttagaacatg 2502901 caggatcttg tctggtgttt ttccttttat tagacacttt atttctttta atggaacccc 2502961 aagctcttta aatagactga tgacttgaaa agtctcaaat tgatgatagg aataatatct 2503021 atacccattt tcttttttta tttccggcga gaaaagacca atctcatcat aatgaaataa 2503081 agtttgtttt tttacacggc agagcttcga aaactcccct gttgtgaaat acttcttaac 2503141 atcttcgctc ataaaaacct ccttgactat acggtaacca tataccttat gatttgattg 2503201 tacttgaaaa aagcttcaag cgaaaaggat aggtaaaaag ggttcaattg agtaaaaggg 2503261 gaattcagat gaaaaaatca ataaatgagc aaaaaacgat attcattata ctattaagca 2503321 acatcttcgt agcatttctt ggtatcggtt taatcattcc agttatgcct tcttttatga 2503381 aaatcatgca tttatccggc agcacaatgg gttatcttgt tgcggctttt gccatttctc 2503441 agttaattac ttcacctttt gcaggtaggt gggttgaccg tttcgggaga aaaaaaatga 2503501 ttattctcgg gttgcttata ttcagtttat ctgagttgat tttcggatta gggacccatg 2503561 tttcaatatt ttatttctcg aggatattgg gtggtgtaag tgcggctttt atcatgcccg 2503621 cggtaacagc atatgtagct gatattacaa ccctaaagga aaggtcaaag gctatggggt 2503681 atgtttctgc tgcaattagc accggcttta ttattggacc tggtgcggga ggatttattg 2503741 ccggctttgg tatccgcatg ccgtttttct tcgcctccgc catcgcgtta atagcagctg 2503801 tcacttccgt ttttatacta aaagagtcat tgtcgataga agaacgccat caactctcat 2503861 ctcatacaaa ggaatcaaat ttcattaaag acttgaagag atccattcat cctgtctatt 2503921 tcattgcatt tattatcgtc tttgtaatgg cttttggttt atcagcttat gaaacggtat 2503981 tcagcttgtt ttctgatcat aaatttggct tcacaccaaa agatattgca gccattatta 2504041 cgattagttc cattgttgcg gtagttattc aagttttact attcgggaaa ttggtcaaca 2504101 aacttggaga gaaaagaatg attcagctgt gcttaataac cggtgcgatc ttggctttcg 2504161 tgtctactgt tatgtcagga tttttaactg ttttgcttgt aacttgtttt atttttctgg 2504221 cgttcgattt gctacgtccg gccttaaccg ctcatttatc caatatggcc ggtaaccagc 2504281 agggtttcgt agcaggcatg aactccacat acaccagcct gggaaatata tttggacctg 2504341 ctctaggcgg tatactattt gatcttaaca ttcattatcc tttccttttt gcaggtttcg 2504401 ttatgattgt cggccttggt cttacaatgg tttggaaaga aaaaaagaat gatgctgcag 2504461 ctttgaatta attcattttc tataaagtta agtcatttgg atgcagggaa tgcccctggt 2504521 taggcacaat aagaaaaggt acttaatttg ataggctaca tgttgcttga cgtgaatata 2504581 gtataagctg agttttagca atatcaggat accgggataa gaaaaaagga gaatgtagta 2504641 tgagtataaa cataaaagca gtaactgatg ataatcgtgc tgcaattctt gatctacatg 2504701 tcagccagaa tcaattatca tatattgaat ctacaaaagt atgtttagaa gatgcaaaag 2504761 aatgtcacta ttataaacct gtcgggcttt actatgaagg agatctagtc ggttttgcaa 2504821 tgtatggatt gtttcccgag tatgatgaag ataataaaaa cggacgagtc tggcttgacc 2504881 gattttttat tgacgaacgc tatcagggaa aaggattagg gaagaaaatg cttaaagccc 2504941 tcattcagca ccttgctgag ttatataaat gcaagagaat ttatttaagt atatttgaaa 2505001 ataatattca tgctatacgc ctttatcaaa ggtttggttt tcaatttaat ggtgaactcg 2505061 actttaatgg tgagaaggta atggtaaaag agctatagat atccaagcct ccttgtttgc 2505121 tgagaaacgt ttgaacttcg ataatgatta cctacttaaa ctgcaagatc attgtttaaa 2505181 aaagcctgga tgaaaatttc atctcaggct ttaagcatct tattagtcaa aatctcatgt 2505241 gttttatcca gatgttattc ttttttccgg acaatttcta aataattaat atgccggcca 2505301 actgtttcgt gcactttaaa aatataccca tcggcttcta taacggaccc aactgcagcg 2505361 tctatttgtt gagtcataaa ccagccgcct attgtatcca cttcgtcact tgctaacgtc 2505421 gttcccaata aatcatttac atcttcaatg agcactttcg aatctaagat atagtgatta 2505481 tcatttactt ttctaatatt aggcacttca tctttatcaa attcatctct gatttccccg 2505541 acaatttctt caagaatatc ttcagcagtg actaaacctg aagtgccgcc atattcatcc 2505601 acaagaatag cgatatgtgt tcgctctttt tgcattttta ccaatacatc atgaattgga 2505661 acggattcaa taacatggat aacagggttg atatgatttt ctaacttgaa atcctctttt 2505721 atcttctggt ctgtgtcaat ataagctgac aaaaattctt tagcattgat aaaaccaatg 2505781 attgaatctt tatctccatt taggactggg taccttgtat agctctctgt cttaatgatc 2505841 ttaacaatag tttcataaga atcctcacta gaaatcgcta cgatctctct tctcggaatc 2505901 ataatttctt tggcgattct ttcatcaaat tcaaaaatat tatttacata tttcaactca 2505961 ttttgattga tttcaccgct cttatagctt tcagacagta agatgcgcag ttcttcttca 2506021 gaatgagcaa gttcatgttc tgatgcaggt ttcaaaccga agagtcctac tataaaccgg 2506081 gctgaaccat ttaaaaacca tataaaaggg aacaggatgc ggtaaaacca aataattggc 2506141 tttgcagtca aaagagtgat ggtttccgct ttttggatag cgagtgtttt aggagcaagc 2506201 tctccaacta caacgtgcaa aaaagtcgcc atcacaaaag caatcactaa gatcaataca 2506261 tgtgagactg tttcacttac atgaaaatga gcaaataagg ggtgcaaaat cacttcaaaa 2506321 gtcgattctc cgacccagcc aattcccaac gctgtaaccg tgatccctaa ttgacaagct 2506381 gacaaatatt cgtccaaatg agtaatgacc tttttggctg atatggcacc tttttttccc 2506441 tctaatatga gttggtcaat ttttgatgac ctgatcttta ctatcgcaaa ttcagtcgca 2506501 acaaaaaatg ctgttaagac aattaaaaga gtaaagatta taaggttaat ggttgtcaat 2506561 gatttgcctt acctagtaag gcgtacacct ccgatgtaaa tatttattga ataaacaaaa 2506621 aacagtatat ataacattat aagttcaaaa gaacctaaaa tcaactctga atgatgtaaa 2506681 taatcatctt tttccgtatg gagagtggtt cccatagtct tcaactaacg attagtggcg 2506741 ttttaaggct taaaaaagaa agcaaaataa aaacacacct gaattttctg gtgtgtttca 2506801 ataataccca accgtcttga tttatttaat gtctttataa agattttctt ttaaaatttg 2506861 aatcaattcg gcctgttgct ttatattttt gcggccattt ctattaattg cagcaagttc 2506921 acagacaatt ccagctgaaa tgaaaaacaa taaaccttca aacattttaa atcccccact 2506981 gtctaagtga tagtcaaatt tgttttttct ttttgcaata cctgcttata atcttcctta 2507041 cgctgatata tgttatttaa aatgagtcca ataatgacaa acagtgttcc tactatatca 2507101 aaagcagtta tgttatatcc tttgatcacc atgattaaca atgtagtaat ggggacaaag 2507161 ttaataaata aaatcccatt aatggatgat aggattttaa tgccatagtt ccaactaagg 2507221 agggctatga tacctggtaa agtaatcata aataaaaaat catacttaat tgctgcaatc 2507281 actttaatac tcggtaccga cacgtaacct tgcgcggtaa gtatagctgt catgattcct 2507341 gttatagctg tgccgaataa acatgtcaaa gttgaataac gaagtgtgga ccactctcgg 2507401 aatatctgtc cccccattgt gtagacaacc caccctaaaa caccaatgaa tataaagagt 2507461 atcgagaata gatgatcccc taatgaaaaa aagaaactta tattaccttt ggttatgacc 2507521 atcgaagccc ccaaaaaggc aatcaatata ctgatcattg tgtatttttt aggtttcaca 2507581 tgtttatatc cccatagaat aacaattgaa agcatcggca tgagtgcctc ggcaatggat 2507641 gctgtcataa ttccagactt ccccatcaac ctttgaccta aaaaaataag aacattgtat 2507701 atagtaaacg ccatcacccc aaataaaatg atccattttg ctttaccctc taaatgaaat 2507761 gatttctttc cttctctcac caataataaa atcactaaca taatcgttac cacaccgtag 2507821 cgaataaatg aaaaataaaa cggatcaaca aattctaatg catgatctgc aactggaaac 2507881 atcgcgcccc aagacatact tgctactaaa catgtaaggg caccaatgaa taattgacct 2507941 tttttcattg aattcccctc cttttcttta aaattacaat gagaattata aaaagaagta 2508001 agcatcaagt aaaatgaaca aaagtgatga aaaacatcat tgataatgat actttaatga 2508061 aggggggatc ttcatggaac tgcgagactt acaaattttc aaatgcgtag cccatcacaa 2508121 gagtattacc ggtgctgcaa aagagttaaa ttatgtacaa tctaatgtaa ctgcgcggat 2508181 taagcaatta gagaatgagc tcaaaacacc tcttttcaat cgccataaaa aaggggtttc 2508241 actaagccca gagggccgaa aaatgattga atacgttaac aaaattttga aagatgttga 2508301 agaactggag caagtctttc tagatactga aataccgtct ggaatattaa aaatcggtac 2508361 agtggaaaca gtgaggatac tgccgaccat catagcttcc tattataaaa agtatcctaa 2508421 tgtggattta tcattgcagg ctggtctaac agaggaactt attaaaaagg tcatgaatca 2508481 cgaattagac ggagctttta tttcaggccc cttgaaacat tctattctgg aacagtatga 2508541 tgtttatact gaaaaactta ctcttgtaac cagtaacaaa acgtttaata tagaggattt 2508601 ttcaacgact ccgattcttg tttttaacca ggggtgcggg tatcggtcta ggcttgaaca 2508661 atggctcaaa gatgaaggtg tgctcccaaa cagaatgatg gaatttaaca tcctagagac 2508721 aatcttaaat agtgttgcac ttggactcgg tataacagtg gtaccggaat ctgctgttat 2508781 gcatctagct gtacaaggta aggtttattg ccacccattg cctgagaaag acagctgtat 2508841 ctcaacaatt tttatacgcc ataaagatgc gtacctgaca aattcaatgc gcagcctcct 2508901 aaagaccatt gttgaacata aaaatatgag tatggcttaa agtgattttt ctctttctat 2508961 attctaactt cttaaataaa agagaaggct catctccact tcgctaccct tattcacgca 2509021 aaaaatagag cagtaaacat gtgagttact gctctgcttc gtttattcac cgttcatttg 2509081 ttttacaatg tattcagcat catttcctac gccttgaagc aacgctgaac ctcgcttatg 2509141 ctgccaaggc aaacctataa agtacaatcc ttctacaggt gaaacacctc tatgatgtat 2509201 gattcgacct tcttgatcca aaacaccttt tatatttatc caacataagg gattcctgaa 2509261 accagtagcc caaataatat tgtttacttc taatgtagat gaatctttaa aaatgatttc 2509321 attttgcttt gcggcaatga ctcttttttt taagatgatc tccttctgtt ttattgcatg 2509381 ttttaattca tgcccaaata ctggatcacc tttcttttga atgaatttgc ctactattga 2509441 tgtatgactt gcatgtaaaa ctcctagttt atcaaaccac caaaagatgc ttctttttcc 2509501 gatcattaaa gggaaataaa caagtttatt actacaagct aaatatgtaa ctctttcttt 2509561 ggataattca acagctattt gagcaccact attcccacca ccaactacta gtacatttcc 2509621 atatgccaat tgttttgaat tcttatattg tgatgagtgt agttgattaa tattatcgga 2509681 taaatccttt gatattgatg gaatattagg ggtatgaaaa ggccctgtag caatgacaag 2509741 attcttcgtt tgatattctt cccgatttgt ttttattaag aaataattct ttatttttag 2509801 gacacttatt acttctgtcc gtaattggat tggaatttca aattttttaa catacttctt 2509861 tagataagca acaatttcat tttttgaagg aaatccatgt ttttctcctt caagatgcat 2509921 tccaggcaaa gagctataca ttcgagaagt aaataaaact aatgagtcat accgatcttt 2509981 ccagctctcc cccacctcat gacttttatc caaaatgata aacttttgat cggactgctt 2510041 aagataatat cctattgaga tccctgcttg accagccccg attactatag tgtcgtacac 2510101 attatcaccc cgccaatttc aaattgtcag tagacagaat ctgcaaaatc ctagttgatc 2510161 tcctcactat aaagttagat aaaaaattta atggtgatgg tggtcacgct gcttctccat 2510221 tttgggctga caaaggatcg cattgtcgtg gttatgcgct tcggtttcca tttgaatggt 2510281 tacgtgcgta atgcctttat gctcaagttc atgttcaatt ttgcgtaaaa tattttcact 2510341 ttctgaaatg gtcagttgat cgtcaacaac tgcgtggcaa gaaagagcat tcaatccgct 2510401 tgtgatagac catatgtgta aatcatgaat gttttgaatt ccctctgtcc cttcaattgt 2510461 acgaatgata tcagagacat cgatattttc tggagttcct tccattaaga tgtgaatgga 2510521 atctttagtc acattgtaac cgcttcttag aacaagaata gccacaatga tactagccaa 2510581 tggatctgcc cagccccatc caaagaagat gataagtatg gcagctaaaa tggcacctac 2510641 agagccgagc atatcgctta ttacatgtaa ataagctcct cttatattca gattattctt 2510701 tgtatctccg ccactcatca taatccaagc gaccaataga ttcacaacta acccgatgat 2510761 actaattgta agcatgccgg ttgttgctac ttttggtgga ttagagaagc gttcgattgc 2510821 ttcataaatg atataaagag aaataagaat taaggcagca ccgtttatca cagctgcaag 2510881 aatctcaaat cgtttatagc cgaatgtctt attgtgattt gccttttttt cagctaatgt 2510941 aaaagcaatc agggcaacca ttaatgaaat tgaatcactc agcatatggc ctgcatcaga 2511001 taaaagcgcc aggctatttg ttaaaaatcc acctatagct tctataatca tataacctgt 2511061 aatcatgata aaagagatca ataaaacctt tttatttgct ccttcattat gattgtgacc 2511121 cataaaaaac tcctccttac ctaaagtttt taatacatat gtatttatta tttcaaatct 2511181 gttatgaagc attctaacat gatacaaata atatttatat atgagcatgt gttcatatat 2511241 aaatatatct gctctttact gaaatgtcaa aatattttta tagaaatcca caatacctcc 2511301 ttaattattc ttttataaac ataaaaaagc ggagcaaaca catggtttgc tccgctaccc 2511361 tagtttctct atccttttct tcaatcaagc atttgagggt agtattcaac tacaatttac 2511421 ctgttaaaaa ttgggcctca ccaagtccaa aactccagtc agcattatca ttttcaacaa 2511481 tagatacaat taaatcagtt gatgcgatac cacactcaga ttccagtctt tcagctaaca 2511541 gcctgtaaaa tttttgtttc ttctcttccg gtcgggattt acttgtaact gaaagaacaa 2511601 caagattttt agttcggtta aatcctaacc cagtatcctc aataatcata tgattttctg 2511661 gatgttcatg aacaatttga taacggtctt gttgaggcac atcaaaagcc tctactacaa 2511721 cattgtgagc gacatctaaa agttttttca aacttgattg atctcgccct tctattaagt 2511781 caaaacgaag taatggcata aaatcccctc cttctactac aacagtcttt ttaatttcat 2511841 tcgttaatgt gtcagctatt tccaagcagc tgctacattt agaaaataaa gtaatttccc 2511901 aataacccct tcattctggt gttagtcaag cctatgttat gatgtgtatt tccataggca 2511961 atatacagaa tcaacttcga gtaattaacc attttttgaa atagctttat cacttacttt 2512021 agaaatcatt tattcttcta agctttagtt tacatgaagc tctgctatca tatataattc 2512081 aaaattaaga tggaagacat ctcaaaatca gatatcaact atggaggact agatgaatat 2512141 tcagttgtta caggtttttc tcactactgc tcgtgaaggc agtatttcca aggctgctct 2512201 gactttaaat tatgcacaat cgaatgtaac gaataagata caacaactag aaaacgattt 2512261 acagacaaaa ttattctatc gtcatagtcg aggaatcaca cttactcccc cagggcaaat 2512321 tcttgtttct tactcagaga aaattctaca tactattgaa gaagctagag cagccatggg 2512381 cgaatcatcc gcgccttctg ggccactgcg tataggatca atggaaacaa cagctgcagt 2512441 ttggcttcct caactccttg cacattataa taacctctat ccaaatgttg atttgaacct 2512501 agtaaccggc cctacggaac aacaaataca agcagtttta cattatgagt taaacggcgc 2512561 ttttatttca gggcctattg aacaccctga tttagttcaa gaaaaggtat tggatgaaga 2512621 gatggttctt gttacaagtg cttcacaccc tgtgatttct tccattcagg atgttcaaac 2512681 acaaacaatg cttgtattcc gtaaaggatg ctcatacaga gcaaagctca atcatatcct 2512741 gcaagaagaa ggtttattac ctataaaatt aatggaattt ggcatacttg aagcgatcat 2512801 tggctgtgta agcgccggct tggggatttc actgctgcct cgttcaatca ttgcttcgca 2512861 tgaaaaagaa ggccgcatcc gcagccacac tatctctgac aaatattctt ttgtatcaac 2512921 tatgtttata aggcggaaag acactttaat tacccctgct ttatctgctt ttttaacgca 2512981 tatgagggat cattttcaga taaagaggcc agatcaatcg taaataaatg gatggaaggc 2513041 atgcttcgcc tcaaaatacc cctgatcagt tgtctgatat aaaaatatag gcgcatctca 2513101 atgtttgtat agagcaaaaa agcaaacttc ggtatgtagt ttgctttttc ttcgtgattt 2513161 tgcactctga atcgtgaaac ctagtcgata ttaggatgta gattttcctc attcaaagaa 2513221 ttttgaacga aggtcattgc cctagacact tggttgcgtc ttgaagttaa aggctgacta 2513281 tttcctaaag cgtcaatcgc tctcacaact attaaatatt cacctacaga tttcgggtga 2513341 caacgggaag attgatattt tcggttggac aggggcagaa catccaattg taacagttga 2513401 agtatccact gatggaggag atcctgcaga tctgagtgat attgctgttg attgatcaac 2513461 ttgtttttgt tcggaatata ctcagtatat agccgcatat tcctcctgca atagctggaa 2513521 tgagccaccc cagccctatg ttatacatag gaagaatctg agtgaaaata cgattcacaa 2513581 cttcaatttt tattccagcc gccttcaaac cgtcaaatag gctgatgatg aatgcgaata 2513641 ataaactgcc ttgatacact tctgtcttcc ctttaaatac agaatgcaaa aacgttaaaa 2513701 atattaagga aatcgcgata ggatacatcg tcagtaagac aggcattgac accttaatga 2513761 gctgggttaa tcctatattt gcgacaagcg tactaaacac tgataaaacg acagcaattt 2513821 ttttataaga aatgttcgga aataattcat gaaaaaatga agaacacgct gtgatcagcc 2513881 cgacacttgt cgtcagacac gccactgtaa tcattaagcc caataagatt gaaccataag 2513941 atccaaaata ataggatgaa accttagcca aaacctctgc tccattttct aaaatcccca 2514001 gttcttcaac gctggaagcc cccatatagg aaagggctgt atacataact gctaagagta 2514061 cagctgcaat cgcggctgct tttgcacaaa caactatcag ctgttttttg gtagaagctc 2514121 cttgttcttt caatgcattc acgatgataa ttccaaaaac aaatgctaca agggcatcca 2514181 gagtgaggta tccttcctga aatcctttaa aaaacgcttg tgatgtgtac ccttttgatg 2514241 gtgcttgaat ggttccaatt gggcgaataa gagctacggc tacaagcaat ccgataaatg 2514301 tcagcttaat tggcgtcaaa aatttaccaa ctatatcaat gatttttgaa ggattgagtg 2514361 ataacaagca tgccaatgcg aaaaataata ttgtaaatat gatcaatgag acagggcttg 2514421 catcatttga taaaaaaggt tttaccccaa tttcaaacga tacgtttcct gatctcggga 2514481 tagcgaaaaa aggcccgatt gccaaataga gaatcgtcgt aaatacaatg ccaaacaccg 2514541 ggtgaacacg gctggctaac gactgtaagt tttgtttacc cgaaaaaaca aatgctgtta 2514601 tagccagtaa tggcaatcca actccggtca ctaagaaacc tgcattagcg acccatacat 2514661 ttttcccggc caattgacca agcataggcg gaaaaatgag atttcctgct ccaaaaaaca 2514721 atgcaaatag cattaatcct ataatgatga tataggaagc agacactttt tttgacatta 2514781 tatatcctcc gattaaagta gacacttctt gaatagccag gaaacattac agatgctatt 2514841 tgcactggca cagtgttgat tccaaaataa gcttgtgtca gttttatata tttttatcaa 2514901 gttaaataaa agcatgatca ttttgatcgt ttccgatatc ggttaaaaaa ccaattgcac 2514961 caaaaccata taaacaacgg ttccccccgc tatggaaaga agcatatttt tcttccacaa 2515021 gtgaagcagt acaacagcag ctgctccaac caattcagga atgccatgac ttccagaaag 2515081 tagactcaca tctttcaaac aataaatgac taaaagcccg attaccgctg atggcagcac 2515141 tttaccaaga tactgtacat atttcggtgt cggtttgcca gacgggaaaa tcatgaatgg 2515201 aaggaaccgt gtcagcattg ttccaagcac gaccattgcg atggtgatca tttgctgcgt 2515261 catagtcatc gtcatacgga aacctcagct ttctccaatg gttttctcag aacagtcagt 2515321 acccctaaaa tggcgagcat agcaggaata ataaattggt ttccgccaaa aaggataaga 2515381 ctggctactg aaagtccaag tcccgtgaga gcactgtaat gctttttctc tttcatccat 2515441 tgttctatga atatcacaat aaacagagca gtcatcacaa aatcaagccc ttcggtatta 2515501 aacttcacgt acgacccaaa aatacctcct atcgctgccc ccgcgaccca atataaatga 2515561 ttaagcagtg tcacaaaaaa cataaaccag cccttatcaa cattcgccgg aacattagcg 2515621 gtataattga tagaaaatga ttcatcgcac attccgaaaa tcagataaag ctttttcttt 2515681 ccagtccccc tgtacttatc caacatggaa attccataaa acaaatgccg ggcattgacc 2515741 attaacgtca aaaaaagagc attcataggg ttgaacgcac caagtaaaaa attcgctgca 2515801 acaaactcca ttgagcccgc aaatatcata aaactcatga tgattggata gattgcgcta 2515861 aatcccaaag aatgcataaa gatcccataa gctatcccca aaaataaaaa ccccgcaaaa 2515921 atcggaatgg tatatgggaa tgcagaacga aatgcagccc atatttgact tctcttattc 2515981 atatgagtgt ttatagcagg agagcttaaa tgtaacgatt ctttattttt attcaaatca 2516041 acaacctcct acatttcatc aattggcaca ctgacagttc ttttttctgt actcatgact 2516101 atgcttgtgt caactccact aatagcaggg ttctgcatta atgaatcaat gataaaattc 2516161 cgataactct ccatgtcctt cgccacaatc ttaagcatat agtcatggct tcctgtaagt 2516221 gtgtagcatt cttgaacctg tgggaatttg tttatatcct ctaaaaatga atgaattgtc 2516281 tccctattta agggtgataa gttgatgaga gctagtgctg tgacttcgat tccaagtttt 2516341 ttctcatcaa caatagtcgt aaacttttta attatacctg cttctactag gttctttgtt 2516401 cttgcaaggc aagctgatgg tgaaagccca attttcttag ataaatttaa atttgatatt 2516461 gaagcatctt cctgcaaatc tcttaagatg gccttatcag tttcgtcaag cataataccc 2516521 atttcacaac ccccaataca acttaacaga attatatttc atacaattta aataataacg 2516581 aatttttatt cgttaatcaa atattattta aatttaaatc cttttaaagt attattcaca 2516641 gaataaaatt atcctcgcga ttaactcata atgaaattaa cttacatcag aaagaagtca 2516701 tgggagagtt atgtacttgt gtgacttgat accaacatca taagaaactt atcagaagcc 2516761 aaaaagttat tgcggtctca ccgaaaattg aatttgcggt gccctattgc ctttttccgc 2516821 gaacgaaaat tgttaaaatt cgcaaaacag aaagtctact ctattattat tttaaattcg 2516881 tcctttagtt cttcttgagc ctcttgtata acttctaata catcgtcagc gtatgaacct 2516941 aaaaatgtat tgctgaactc aaaatttttc aagactaaag tgagcggcaa atccacccac 2517001 cctgtcaggc aatcccataa agcgtctaaa tttctcccat agtagtctgg gaagtctagt 2517061 ttatctttta aatcatcatg taaaacttct atattttcaa agtctcttcc atctattatt 2517121 atttttctca ttagaaacta tgccctccat tattttatct taacaaacgt ttactatgta 2517181 acagctgttt gtccaaatga ggctgaaaac aaataaaaaa caccgatagg atgaaactat 2517241 tggtgtttgc aagacatctt catacccggt aggcataaat aatgctaaac tttgttttta 2517301 aaaagctatc atatcaaatt tttatgttac agcttttact atcgtttaat ctaattgagg 2517361 agtaaaacaa gatatgtttg aaaatcacat atcccctaaa aattaaaaac taatcggcag 2517421 ttcttcgagt gctctcatca gaaaattccc tttccatttc atttgtttct tttcgccttt 2517481 taactgtata tttggacagc ggcgtaataa ggtggaaatc gcaatctttg cttctaagcg 2517541 ggctagctgt gcaccaagac aaaaatgatt gccatggcca aaagcaatat ggcggttgtt 2517601 ctttctttca atatcaaata tgtcggcatt tggaaatatc ttttcatcac ggtttgctga 2517661 tgctaaagaa atgatgatca catctttccg tttaatctcc tgcccatgca gtataaacgg 2517721 ttcagccgtc cagcgaattg tcgttagctc aacagggctg tgaaaccgca atgcttcttc 2517781 tatggctgaa ttcatcaagt ccggctgctg gcggagcttt tctagttgat catggtgaca 2517841 catcagagca tatgtcatat tggtgattaa gtttacggtt gtttcatgac ctgcaacgat 2517901 aagcagcata atcatcgagt acaattcttc tgtacttaat tgtgtgcctt cactttccgc 2517961 ttgaattaat gcactgatta aatctcctgc aggttctctc ctttttttgc gaactaagga 2518021 ttccagatat tcaacaaact cccctaacaa gtggtcattc tcctgaagtc tttcaggggc 2518081 atctgaaaaa tcaataattg cttgcgacca tactctgaat ttttgacgat cttccaaggg 2518141 aatgccgagc atttcactta tcacgataat cggcaatgga aacgcataat cgtctactag 2518201 gttcatgaat ttgttgggct gcactttatc caataaagaa tctgcgatat gctggatttt 2518261 gtcttccaac tgcaaaatca tccgatgcgt aaatgctttt tgaacaagag ttcgcaagcg 2518321 gttgtgatca gggggatctg aattaagcat atgttttgtt aaagtctctt cattcttcaa 2518381 tagagcagga cgtttttctt ttgcggtaaa tacattttca tagtttttct ttaatttttc 2518441 attctttaat aaatgtattg catcatcata tctcgatatg agccagcctt tccccagagc 2518501 tcctaaagat aatgggtaga gagcctgtga ttttcgcaat tctttataaa attcatacgc 2518561 ttcatcttta aatgctctcg aagacaattg actttccgtc aaaatggtta cactcttttt 2518621 ttcttttgaa gacattcatt cgacctccat ctttgaaagg ttatgataat ctttaaatat 2518681 aaaatcagga cgatttgtaa aatgatccat tgagatcagt attcatgata agggccaaaa 2518741 tgccgtcccc gcattttgaa ataaaagata tgagacagtc attaatcatt ttgctgccta 2518801 aactctttcc ctgataaaat ggcgaaactc ctaatacttc tatgccggct cttttaagga 2518861 tttggaaaat tttttagccc cattttgatt aatgttatcc cccctgctgc tatataatcg 2518921 atcaagttta atgtcgggtt tatcacgatg ttttaataga gcggcaacaa ccatttcacc 2518981 attctgaatg ccaacaaaaa agaaatgctt tttaaaatat gctcttgtca gtactttatg 2519041 catttcaaaa ataaatgaat gatctttttt tcgcgtttta cgagtaaatc cataaaagga 2519101 tattgattga aagattgatg gaatagcttt gccactttgc ttacttcatc tgctcttgct 2519161 tgtcgataaa gaaacattga tgcacctcct ctgagcagta aagcaggaaa tcgaattaaa 2519221 gcgcccttcc tattggaaag gcgcctgccg ttttactgtg ccaaaatgtt tttcatcagt 2519281 gagtttttat aaaatcattt attaattgat cagttgtcaa tattgtggca aattcatcat 2519341 gcaatgtagc tagagatata ttatgaatag tcgccgcatc ataatatgta tcattttggt 2519401 ctctcattcc gaaggctgct gttgcatctg aaatcaggta tgtatcaaac cctaaattac 2519461 cactcattct tgtggtggtt gatacacagt gaggcgtggt taaaccagtt atgactacag 2519521 tggttatttc atttaatttt aagaattctt ctaaattcgt accaataaag ctgctattta 2519581 ctgtcttggt tataatgact tcttcatcca taggcttaac tatttccttt attgcaaacc 2519641 cttcattctt tggatggaat aaagaatgag gtttatcaga agtgtgttgt atgtatatga 2519701 ctgtccatcc tttttctctc cataattcta gtattttact aatgttttct tccgccttta 2519761 cgttattccg ttccccccat tttttatcat cgaaggcttt ttgtacatcc acaatgatta 2519821 aagctttctt ttcttccaca agataccctc ctacgtagaa tttctattta ttactacatt 2519881 ctaaatacaa attttacttt tgtacaattg tttaatgatg aatttcaaat gagcgccttc 2519941 tttattggaa aatgcgttct atactgcaac tgtgcccaag ccgttaacct tcaaatctaa 2520001 tctgagaatc actggctcta cagagaataa taaaaaacac tctaataacg agtgctgaaa 2520061 tgaaaaacta ttgatttaga agccatttga tacgctcagc tgaaatgatg tagtggagta 2520121 ttataagaca taaaaagaca atactaactg gttttaaata actaaaataa agcgctgcaa 2520181 cagccattgc aaagatcaat aattcaataa ctaaccttgt tactccgttt acagctatta 2520241 cagtttgtcc gcttcgacta ggatcatgag gtactgcaaa tacagaccag acaatcataa 2520301 ctgcaatagg taaaaccaaa gttaaaacat atttaaaata accattaaag cttatccaag 2520361 catacacccc taaggagatt agtgcagcaa tttcaagggt gaatcttaaa agtaaattag 2520421 tctgattcag tttttccaac tcctctataa aaaacacccc cgcaggagat gctctttctc 2520481 tgctttattt cagcgtataa aaacttttct gttcttcctc tttagattct attgtagttt 2520541 tcggcgagat tacctctact tttgaagaga tgataccgac tgctgctgtt accaatgctc 2520601 cgataataga acgatgataa gtataatgaa atatgacaac ttttcccctc ctattcagtt 2520661 aattatccaa ataatcagga agttgtctac aatttgcaga atttgtcgaa cgaagtaaag 2520721 attatacctg ggaggcttta ctcattgtat gaattacagt aaataaattg ccttcccttt 2520781 tgagaagacg ttccaactca gctagactct tccaataggc ttccttttgg cgcagctgct 2520841 tttattcaaa aattgagcaa cacctgaatg tttcattgga atttctgaac catcgatcgc 2520901 tgctgaattt gttgcaaatg catacgtagg agtagtcgaa tggtggttga aaaatgaaat 2520961 gccttcccca cctcgagtga tggcagaaaa agcgggggtt ttgttagaga ggaatctata 2521021 gatatgtgta tcgaagattt gacagcatta aaaattatac ttacatcgtt gggaacaggc 2521081 caacaataaa gcggaagaac gttgtcattt gaagtggttt ggaataaaaa tgattcgaat 2521141 atgttcttat cattgtaaac gaacaaaaaa agaacatgtt ttgaaaaaag attgatcaaa 2521201 acatcttctt atatgttgtc atagcgtaac tttttataaa aaggttaatt acattttcgg 2521261 ggcttccaaa ccaaattttg cccattcttc ttttgctgga ccataaatac ctggaacagt 2521321 taaacctgct tgtctcataa gaacagtcat ttgtccccga tggtggtttt gatgttgaat 2521381 taaaaacatc aaaagtgaac cgttaggcat ttgttgtcca ataaagttga tacgttcttg 2521441 aagtgtatgg tcagtccatt gggtttttaa tgcctgtaca aatgcattac tggcttgatg 2521501 atagctgtca gctataaact gagcagaagt tggaacagga taatcttcag ctggggcttg 2521561 gaacgttaag tctgtgtttg aggtaatgat gccaatggca gcaacagtat gccaagcaat 2521621 acggcctaga gtccaatttt gtgaagttat ttcttgttta agtgattcat cagtcagact 2521681 atttaatagt ttctgtgtag catctgcttc gaactcccaa gatttcaaaa aatggtctaa 2521741 ggtttgaaac acaaaaatcc tccttttcat tcttttgttt tttcaatgtg cttataggtt 2521801 aattataatg cctcctttcg ttaaaaagaa caaaaatttc ggacaagaat aatcatagta 2521861 aaatgcgtag acattcttaa acgtaacgat ttacgcatct ttttacaaac atctgactac 2521921 ttggtctcca ttgtcagcga gaatcaaata tcatatgaag acaatcctat attcttatca 2521981 ctttactgag caataaatac cttccgtata cttagtaata ccttcatcgt aatcaggata 2522041 cttatatgca agaccttctg atacagcttt tgaatacttt ctaaataatg catagcaagt 2522101 aaataaagac ttccacattt cctgataccc attcacagaa tatgtagaca tgagttcctc 2522161 ccattcttta tttgaaaggt accgcttcat aaatttatag ttcttcccca tactaaatga 2522221 ataccctttc tgagatgcga tatgccaggc catcattctc aataaattag gacgtacaat 2522281 ttcatttaaa tggtcaatgg caaaaaggat ttcatttctt gctagtcctt ttactacgta 2522341 agtcgaaacc atccagaact cattacagca atcatcaaat tcccttgcag tcggcctttt 2522401 tatccagtat tggcgatcat ttggggtcac tttatagttg atgaacgaat ccttatcaag 2522461 caatacctta accaaaccat cgttattagc aaaataatct tctgcttcac gaattggaat 2522521 aagggttaga tctaatttgt tgccatcctc aaaaagaata atgtatgaaa accaattacc 2522581 taattcggga ggaaaaagct ccatatcttc tggtttttgc atcataatgc gcttcccaaa 2522641 gatttcgagc cactgatcat tttctttaaa agattctaca tcagttacaa aatacgagat 2522701 gtcataatct tggaagttgt caggagggat atttctgttt gtacgtgacc cttccaaagt 2522761 gaccaatcgg attctctcat cgttcaaagc aaagtccaaa aaaatgtcca tcatttcctg 2522821 ctcacttcgc attacatgtt cctccgtttc agccttaata tctaactgta aaacgtctta 2522881 tagatttttt tactcttgaa tgtgatgtat tcttctaagc tttattttac atgatgttct 2522941 cctatatatc attcaatatt aagatgcaag acatctcaaa atcagatatc aactatgacg 2523001 gactacatga atattcagtt ttttgtagag ccgccatggg acgacactat ctttgacaca 2523061 ctttaatccc ccctgcttta tcgacatgtt aactggtatg agagattgac aaaaagaagg 2523121 aaaacgatat atttaagcga atacgagttt ttgagtaaat tttaaaatga cacttttttc 2523181 aaaaatcatg tcttaacggg aggattcggt atgaatgaat ttatgaaaaa gttttcttta 2523241 acaaaaccga ttattcaagc tccaatggct ggcggtatta caaagccccg acttgcatct 2523301 gcagtttcga atcaaggtgc tcttggcagc ttagcatcgg ggtatcttac gccagacctc 2523361 ctagaacaac aaataaaaga aatatttgag ctgacagacg ctccttttca aattaatgtg 2523421 tttgttccgc taggtctaga gatgccacca aaagatcaga ttaaaaagtg gaaagaaaac 2523481 ataccgttag ctaatcaagt aaatcaattc acatctgtac aagaagagtg ggatgacttc 2523541 tatcaaaaaa ttgatctaat tttaaaatac aaggttaagg cttgctcatt cacttttgat 2523601 ctgccgcctg aagacgcagt aaaggagcta aaaaccgctg gatgctgttt aataggaacc 2523661 gcttcaacag tagaagaagc attgttaatg gaagaacggg gaatggatat agtagtcctt 2523721 caaggaagtg aagccggtgg acatcgcgga gcattcttac cttccaaagg tgaatctgcc 2523781 gtaggtttaa tggctctgat tccacaagca gcagatgcac tgagcgtacc tgtcatagct 2523841 gctgggggaa tgatagacca cagaggagta aaagcagctt taaccctcgg agcccaaggc 2523901 gttcaaatcg gttctgcctt tttaatttgt cacgagagta acgcacatcc agtgcataaa 2523961 cagaaaatac tagaagcaaa cgaagcagat acaaagctta cgacattatt ttcaggtaaa 2524021 gaggccagag gaatcgtaaa taaatggatg gaagaaaatg aacagtttga gacacaaacc 2524081 cttccgtacc cttatcaaaa tacactaacg aaggcaatga gacagaaggc ttcacttcaa 2524141 aataaccatg atcagatgtc tttatgggca ggtcaaggga tacggtcatt gactgaggaa 2524201 atttcggtta agcagctttt aaatcagctt tgccaagagg atataaaaat ataggcgcac 2524261 ctcattgata gagcaaaaag caaactttga caggcagttt gctttttttt tcgtaatttc 2524321 atccactgac tctggaaatc taaatactcc tacattttca aagctaattt gaatcgggtt 2524381 atcaatcatc acattgatac gatgcgatct tgataatttc accacaacca caatacatta 2524441 ccaacatttc gatcttatct ccccttctca agttttgctc cctattcgaa taatcgatag 2524501 ctcccatatt aaatttgaat agtaaaatgg ttctttttcg tttgattcag atgatataaa 2524561 gtcatatgat aaaaaaagaa tgagacagaa agcgtgagaa gtgatgaaaa taggattttt 2524621 tgattcagga attggtggca tgactgtatt gtatgaggcc ataaaagttc ttccttatga 2524681 agattacatt ttttatgcag atacgttaaa cgttccatac ggtgaaaaat caaagggtaa 2524741 agttaaagaa tatattttca atgcagctga atttctggcc agtcaaaata tcaaagctct 2524801 tgttattgcg tgtaatacag ctactagcat tgcgatagag gatcttcgga gaaacttcga 2524861 ctttccgata atcggaatcg aacccgctgt aaagcctgct ataaataaat gtacagagga 2524921 aagaaaaaga gttctggtag ttgctactaa tttgacgctt aaagaagaga aatttcataa 2524981 tctagttaaa gaaattgatc accatgacct tgttgattgc ttagctcttc caggactagt 2525041 tgaatttgct gagaactttg attttagtga agacaaaatc attaaatatc taaagaacga 2525101 actatcttct tttgatctga aacaatatgg aacgattgtg ttaggatgca ctcattttcc 2525161 gtttttcaaa aacagttttg aaaaactgtt tgggataaaa gttgatatga tttcaggcag 2525221 tgtcggtact gcaaaacagt tgaaaaaagt tcttgcagat cgtaaccagc ttggtaaagg 2525281 atcgggctca atcacctttt tcaattctgg ccataaaatt gtggaccaag aagtcatatc 2525341 aaagtacaaa agattgtttg aaatattaga tgaaactcaa aggagtcatg ttggacattg 2525401 aatgtaaatg aaaaagacaa tctcctgaag agaaacatga actaagaagc gggcttaaaa 2525461 agcccacttt ttttctaaca aacaattgag ttatacacac atatctgatt acagtgtttt 2525521 ctctctttcc cctcttattt ctcccccctc tctatagctt ttctatttca ataaaacaca 2525581 agtctcgatt gaaaagttat cgtaacattt acacttcaca ggagattttt cacgattgcg 2525641 aatcgaccgt ttgccagatg cacaaagtca taatgtgtaa attctgtatc tatgtgcatg 2525701 tttattatgg aattattttc ataatgtttt ataatacaag atgatagcgt tttctaatta 2525761 taatgatagg gggaaataat gatgatgaaa aaaggtctgc ttgcgggtgc gcttacggca 2525821 accgtgcttt ttggcacatg tgcagtagat gtaccgggta ttattagtcc aaaaaccgca 2525881 gaagctgcat cacagctaac tgatggaatc ggcgggaggg cttacttgaa cagtaatggt 2525941 gccattcttg ttacgaaaat ccagcttcct agctccactc aggtttcaaa tgggacagcc 2526001 tacatctact ctggttttag cggaggcaca gaatccgata tcgggtttca gtacagtgat 2526061 aaatataatg tatggaaacc atatatgaaa gtcggttcaa aaggacagga tcaggttcag 2526121 tacctcgaag gaggaagcca attcacgaat acgaaaggct tccgtcccgg cagcaccgta 2526181 caacttacca tctacaaaaa ccttaacggc aatacccgcg ctacatactg gggcacgaac 2526241 aatgccggat acaacggccg tctcatttca gaaatcagca aaacaaatgt cggctccatc 2526301 tcaaaatgga aagcgctcgc tacagttgca acaacagggt cacgccaatc tatcaaatca 2526361 aacttttcaa catcttttac aaacatcacc atcgacaaca aagcaataac acctgtaatt 2526421 gatacacaag acttcgctaa agtaacagtc tcaggcaaca gtgtcagttt atccgttgtc 2526481 aaaaattaaa acatgttaaa catacaatgc gttaggctat tgagaagctc tcgatagtct 2526541 taaagggggc ttaacatgcc ccttttttca tttcaattta actttcagtt agcttcggta 2526601 catgccgtct atccccgtct tttatctggg tgaagtaagg gcagctcgcc ccttctgaac 2526661 ctgttccatt tgctcaacgc aaaaggtgtg catcactgtc ttaaaaatgt taaaacaaat 2526721 agcagatggt gcactttatt tttagatgag gcatgcttac gctcgatatg caagtcaaat 2526781 gattaagggt ctgcaagaga gagaagtttt gggtgtactt tcataaaaga gggatggctt 2526841 catatagctc gattgcatca ggaagattag ccaacgattg gccgagaaca acacatcact 2526901 ttgaaacgga ttcattccaa aatcataagt atgatccaat aactaataaa gatcagttag 2526961 cagtccagcc ttaaaaatat ttttacatca attaaactag catcactatc gaataagctc 2527021 gatctgcata tcatgtacta tcctctttta aggaaggtga tgttatgagg tcatttccat 2527081 taatcgtagt tctattcatc ctattaatca tcgttgggac atctttcttt ggtggctatt 2527141 aagaacacac cttacctcat atccatcaga cgccataaga aatctttatg gcgtctgttt 2527201 tttattagat ttaaacaaaa ccattaaagt gggccatgca aacacaccta tggagattac 2527261 tgccacgact tctttgtgag ggaattattc ttccctttat ggactattgt cgatcaaaag 2527321 agaaagttga aatgcatttt tatggtgaga tgaatcgagg cttagacata taaaaaaccg 2527381 caaagctttc ttgaagaagc tttgcggttt ttgggtctct tctttgcttc atataagcca 2527441 atagatttca agcgtaatcc actgccatac atccaatgat tttttatttt gaaataggtt 2527501 tcttctactc ttcatgtgag atgactcaag gtatgccacg tcacaataat atggcggata 2527561 ctgaatggtc tcaatcagtt ttttccccat tctatcaatt ctccacagaa aaaatggcta 2527621 tggcagaaca actttcatag agtaatcatc atttaatgag ccatcatctc atgggcaata 2527681 tcgtgtccat ccatttttga cgggtagtaa gtaggccagt ttttgacttc atcaagtaaa 2527741 gcttcacggt cgtcccccca atagagatgg taatgactag ctttagtcgg gtaaatacta 2527801 tgatcactaa actgaatata ctgaggcagc ccttctgctt ttttagctag tttgaatatg 2527861 tatcttaccc ctctattgcc cgcatcatag gttagaattt cgtatccgtc atacgtatac 2527921 ttaccagaat attcttttcc atttttgaag aacgttacag tatctttctg gattacaata 2527981 cggtcaacat ctgtttgata gcctttttta taatactctt tatattcttc agctgtcttg 2528041 ccgccttcgt gttctgattt atatgaaaac acttcgtcaa gagtaccatc ttgcaggtat 2528101 ggatatacag attgccaatc tccttcccaa tcagaaagta agcgatcctt tacttggctg 2528161 tttttaaaat agccttcata tattttttct gtttcttcat catgcgcatg actatgatcg 2528221 tgagaatgtt cgtgtgtatg actgtcagat gtttgctctt gcgttttgga agagtcttct 2528281 tcaactgctg aggatgatgt tgtttgatta gactcacctg cagaagaacc ggaagtctga 2528341 catcctgcca aaactagtaa tgaaccaatc gttaatatgc ctagccgttt tgaaaataaa 2528401 atgttcattc caacactcct tttttattaa atcgaaaaca ttacgattta ttatacatac 2528461 atctcttgca aacatcaaag gaaaaatgct cttcatgcgg atggcctatt ttaaaggaat 2528521 aactgactat gttcatcagt tattccttta aaatacgaaa gtctacgata tttccatatc 2528581 gatccgcttc aatgtgacag cacccctcaa gcagctgttt taattttcca cgtccgcgtt 2528641 gtacccttga ttttgctccg gagtaagaaa tgccgagctt ttcactcaac tctttttgtg 2528701 ataacccctg gaaatcagtt aactcgagcg cctctcgata cttttcaggc aaccgtttga 2528761 tggtcgatcg aatacacaca gttgcttcct tggtgaaatt ttcttcctct gcactgtcat 2528821 taaaatgtag aacatcaggc aatatttcgc ttgttttttt tgtacggtaa aaatcaataa 2528881 tcgtatttct agtgatccga taaatccagc tgtcgatctt ttgttcatcg atcagatttg 2528941 ggagatgcac ttgtattttc ataaatacga tttgcaagag gtcatcaacg atagattgat 2529001 cgttaaccct atgtgaaata tatgttttta acggctgatg aaattgatcc catagatcct 2529061 ctatattcat ttgaaaaaac ctcctataat tttgcgtctg ctttacattt gcttcgtctt 2529121 tttaatcgta acaaagagca aacaattgtt gaatcaattg tattgcagct gttgccaaaa 2529181 ataatgataa aggagaggtt tgttgtggag tatacctatt tagggagaac aggattgcgg 2529241 gtgagccgtt tatgtttagg cacgatgaat tttggagttg atacagacga aaagactgcg 2529301 ttccgtatca tggatgaagc acttgataac ggcattcaat tttttgatac tgccaatatt 2529361 tacggctggg gcaaaaacgc aggattgaca gagagcatca ttggaaaatg gtttgcacaa 2529421 ggaggacagc gccgcgagaa agttgttctg gcgacaaaag tatatgaacc gatttctgat 2529481 ccgaatgacg gaccaaatga tatgaggggc ttgtctctat acaaaatcag acgtcatctg 2529541 gaaggatcac tgaagcggct tcagacagat catatcgaat tgtaccaaat gcatcatatc 2529601 gataggcgga caccgtggga tgagatatgg gaagcttttg agactcaggt tcgctccggc 2529661 aaagtagact atattggatc cagtaatttt gcaggctggc atttagttaa agcgcaagct 2529721 gaagctgaaa aacggcgatt catgggactc gtcactgaac agcataagta tagtttatta 2529781 gaacgaacag ctgaaatgga agtgctgccg gctgcacggg atcttggttt aggagtagtg 2529841 gcgtggagtc cccttgcagg agggcttctt ggcgggaagg cattgaaaag caatgccgga 2529901 actcgtacag caaaaagagc agatttaatt gaaaaacatc gtttgcaact cgagaaattt 2529961 tcagatttat gcaaagaact aggagaaaaa gaagcaaatg tggctttggc atgggtgctg 2530021 gcaaatccag ttttaactgc gccgatcatc ggaccacgaa cggttgagca gctgcgtgat 2530081 acgataaaag ccgttgaaat cagtctggat aaggagattc tccgcatgtt aaatgatatc 2530141 tttcccggac ctggaggaga gacacctgag gcatacgcct ggtgatacat tcattactca 2530201 atactgacat ttttcttaaa tatttatact gaactatcat attaagaaag acaagagcat 2530261 gtttgtctct tgtcttttcc acatcgtgct gaaaatgctg gctaaacatc gacaaaaatg 2530321 ctgccgctta aaaaagaacc ctaaacaata gagtaactgg aaagacaact ggcttgatca 2530381 gcttgggacc cctttcagct gtatttaaat caatcaaact aatgattcat tggcagtcta 2530441 aatattatta ttgtttcttt acaaaatagt aatagcccct gtaatgattg ctaacaacgt 2530501 aataactaat gatgtaatta cagcccactt aacggcaaac ctttgaaatg accccaagtc 2530561 cattttaagc atgcttacta gcaatactgt tgacgcaacc aatggactca tcagatgaac 2530621 cggctgcccc attatagaag cccttgcaat ttctactggt tctataccat atgctgaggc 2530681 agcttctgca aagataggta ccataccaaa gtaatatgca tcatttgata aaacaaaagt 2530741 aaacggaata ctagtgagtg ctacaataac ggggaaaaac cctcccattg atgaggggat 2530801 gatggatatt aatgatcctg ctatggcatc caccatcttt gtcccggata atataccagc 2530861 aaatactcct gctgaaaata ccaataatac cacggttatg gcattaccag aatgctcggc 2530921 gattcgctcc ttctgcattt ttacattcgg ataatttata gtaagggcaa gaacaaaacc 2530981 aattaaaaat aaaactgacg gatgcttagt tccaagcaca ataaacacca tgatacttat 2531041 aacgaggaat aaattaagat atattaagcg tggccttttc aattgttcgc tctccaaagt 2531101 agcagccata taagattgag agctgtcctt tgttatatgt ctaggctcta attgaacgat 2531161 gcctattcga ttcctctctt tccttcccat tagaaaagcc agaaatatca cacaagcaat 2531221 acctccaagc atggtcggaa gtaatggcac aaagaaatct gaaggatcca aacccagcac 2531281 tgaaatcgct cttgtagctg gtccgcccca tggagtcatt ccgctaacga tactcaacga 2531341 cagcattgct aatgtcgcca taaccatggg attcatacca attcttttat acaaaggtaa 2531401 cattgctgag actgttatca tataggttgt tgtaccgtcc ccatctaaag cgataagcat 2531461 tgccaagacg gcagacccta tcgctatttt cacagggtct ccctttacta tagataaaat 2531521 tttttctatt agcggatcaa ataaacctgc atcaattaaa attccgaaaa aaagaatagc 2531581 aaacaatagc aatgccgctg aacttgcaac tgtttgaatt ccttctaaaa tcatgtcgcc 2531641 aataccctta ccaaaacctc caataagagc aaaaacaatg ggagtgatgg tcaaggcaac 2531701 aataggcgag actttctttg tcattattaa tattgtaaaa acagttacca tcgaaaaacc 2531761 taaaatagta agcatattac acctccaaga atgcgctttc aaatgacttt tgattaacat 2531821 atcttatacg gtgtaataag ttaaataaat atttttttac tgtgtttcaa aaaaaattct 2531881 atcataactt taaatggtta ccatttgttc accctttaaa aaatcaatga atgctttaac 2531941 gagtttgatt cctaatgatt tttgatcgta cattagccaa gtatctctca ttagaggctt 2532001 acccttagca ttatacagtt ccattgtgta caaatgatca gattcctgca ggcaaatttc 2532061 tggtgctatg gagtaaccaa gaccatgctt taccatctct ttgcaagtct cttgtcgatc 2532121 cacttccatt gcaataatgg gggcttgttt tagattcgta tgcatccaat cttctataat 2532181 cgtttttaaa gaagcatccg ttttatattt gataaaaggt aaaaaaggaa gttgctctat 2532241 cgttattggt ttttttgaga tgatatgtaa tttttcccgt gtcagccgtt cctccacccc 2532301 tttccagcga tggcttcctc tcagtatacc gacttgtaca ataccagcat ctaataattt 2532361 catgacatct gtgctccagc ctgtttgtac actatattgg acattaggat acatagtgga 2532421 aaattccctt aataacttag ggagcttata ttgagcgaaa ttgcttgata cccccagcct 2532481 tagatgtcct tgcacctctt tgcttagatt agagatatga tctttggtat cttgaagttc 2532541 ctgtagcatt cttcttgcat aagcaaccaa gtgttctcct tccgcagtaa aggtaattcc 2532601 tttatgcctt ttggtgaata attcaattcc gaaaatctcc tcaatctttt tcaaccgata 2532661 agtgatggaa ggctgtgatg taaataatcg ttctgctgtt tttgttacac tttgttcttc 2532721 gtgaagaatt ttcaataaaa tccaatcttt ctcatccatt ttcatcttcc tttctagtcc 2532781 ttctttcaca attataaaag tttttttatc gaatattaag aaaacttata ttttattttt 2532841 atttttttac cttctacact aaaaaacata aaaaatacta cctttaagat gaggatgatg 2532901 acgatggtca agacgaatgt aacaatcatg agaggcggaa caagcaaagg cgtttttttc 2532961 cacgaatcag ccatgcctaa caataaaaac gaatgggagc cctttttgct tgatgtcatg 2533021 ggaagtcctg ataaaagaca aatagatggt ttgggtggcg gtaattccct tactagtaaa 2533081 gtggcaataa taaagaaagc atatacttcg gatattgatg ttcactatac tttcggtcaa 2533141 gtcagcattt cggaagaaaa ggtggacttt aaggggaact gcggaaatat ctccgctgct 2533201 gttggtccat ttgctattga agaaggactt gtaaaagcga aagaaccaat gactgcggta 2533261 aggatcctga ataccaatac gaataaaatg atcattgcgg aagtagaagt ggaagacggt 2533321 caggtcaaat atgacggaga tgttacgata tctggagtac ctggatctgg atctccaatc 2533381 tatttaaact ttcatgatgc cgctggttca gttaccggtc atttattgcc tactggaaat 2533441 agttcggagt ttttagatac aagtcaaggc caaatagagg tgtctattat cgactatgca 2533501 aatccattag tttttgtgga agcgagcagt atcggcctgg atggaacgga acttgcagaa 2533561 gaatttactg atctacagtt ggctcaattt gaagaattaa gatccattgc ggcagagaaa 2533621 tgcggctttg ccagtcgatt ttcagctaca aagttatcgc cggctgtccc caaactggct 2533681 atagtagcaa aaccagagaa atataaagat agtacaggtg cttggcattc aagcgttgag 2533741 atggacttac acatcaggat gatgtccatg caaaagccac atcaagcact ggctgtcact 2533801 ggagcgatat gtacaacaag agccctttca gtggaaggtg caatccctgc aagaatagca 2533861 aaaaaccact ctacaaaggt tcggctagct cattcttctg gtattattga aacaatggtg 2533921 gagcccactg gtataaagat cgtccgtacc gcacgacgta ttatggacgg aacagtttat 2533981 acgcatggag actatcaaat gatgtagatg gactgtgcaa aaagcctccc ccctttccat 2534041 cgttaataga tggattgaat gcgccttctt gcacagatcc attgtaatct tgcatggctt 2534101 taaaaaagcc tctatattgt tttttatgaa atcgccaagg tcctttcatg tatctgcctc 2534161 aagcatgaca taatcattat agagaaaatt gaatactttt tactgcaaat aaaaagatac 2534221 caacatcatt ggtatctttt agattgagtt catctgcagc ggtttctttt cctcactgct 2534281 tatttgatta caaaattacc gtactcgttt gaacgaacat gaatcggtcc gtttagatta 2534341 tagttgttct ccttggcgat agagcgaagc acgtccacac gggcaactga ttctctccat 2534401 tcgtcacggg tgtcatgatt ggccggattc atcagatcgt catagcgtac gtccaagaat 2534461 ttattcaacc acttcttctc gtctattccg tctttaggtg atccgcccgc ttttttgttc 2534521 gtacgtttaa tcaaggcata aaaagagtca gggtcatcac catcgccatg ctgaataacc 2534581 gtatcgtaca tcacagctct tgccaatgct gtttttagtc cggcattatc cgatcgtttc 2534641 atggcaggct gataatacaa atggtcattt actttgtctt gagcggcgcg aaattcctta 2534701 tcatttgcaa gcgacttcca ggcagaagcg aatcccttga gattgcttgt atcatcgctt 2534761 tcttccttgg ccagacggcg caattcaggc agatactttt tcagtttgtt attcggaact 2534821 gcctttgtgt atacttccac tacttccaat gcatccccgg tagccgttgt aaagcctgcc 2534881 cgtccgcatg tatagcctcg cccgtcatcc aatcgctcta catatccata ttggatctcc 2534941 gttgtgccgt tttcaaagat acttgtcagc tgttccgccc ggcgcttttg atctttattc 2535001 agtcccgccg caaaaaccgt ttcgctcatc atcagggtaa aaaacatggt gaaaacaagt 2535061 aatgagatcg ctgctttttt ccaaaaatct gctttttgca tactgatttt catttcactt 2535121 cccctttcta aatattgtaa atacagactc agtatacatg aagaaactgc cctattgttg 2535181 aaaatacatc aatttgtcaa tattttgaat ctaaagtaat atagcttgaa tcttactcta 2535241 ttcattgcca atcagcctta gcccctctca ctgggaaggt cccttgattt tcatactgct 2535301 tcaactttca ttaacaagat gccataaggc tttactctat tttataatgg aagtgatcat 2535361 cgaaaatcgt tagggaggtg atgtaatggc aagcaagatg agaatgccag attccgcaac 2535421 gtcccatgca aagcctacta ttgggaaggc gatactttgc atggggtaga ctttctaaaa 2535481 gatcgcccaa gtaagctttt ctgatatagt ggctttgcac cttatttgac ataaaaaaat 2535541 aaggagctgg cagaaatggc atatgtaaaa gcaaccgcta ttttacctga aaagctgata 2535601 tcggaaattc aaaagtatgt tcaaggaaaa acaatatata tccctaaacc tgaatcctct 2535661 catcaaaaat ggggtgcgtg ttcaggaaca agaaagctga tcgatgacag aaacgcttct 2535721 attaaaaaag catttaaaaa cggcaaaacc attcatcaat tatctgatga atatcacctc 2535781 tctattgaaa caataaaaaa aattgtctac tctaaataaa caaaacggaa gcactgataa 2535841 aaaataatca gtgcttttta tatggcgagt ttgtttctta gttatttcct gcatatgata 2535901 ccattggcca attgtgtaaa gttaagggag atgagaagaa aggaaggtcc tacaaatgac 2535961 gataaacaat ggaacgttgc aagtacccgg cgcgaacatc cactatcagg tgcgtggctc 2536021 tggtccaatc attcttttgg tccacggagg aggcggtgat gccgacaagt tccatcatgt 2536081 tgccaatcat ctggctaact ggtacacggt tgttacttat gatcgccgcg gccattcccg 2536141 cagcaatctc gccaatcaga ttgagggtta ccgtgtggaa acacacagtg acgatgctca 2536201 ccgtcttcta gccaaaatca ccaataagcc ggcctatgta tttggaagca gctccggggc 2536261 tgttatcggg cttgatctgt gcatacgcca tcccgaacaa gtacatgtca tgatcccaca 2536321 cgaaccaatc ttattgcagc ttctgcatgg aaatgagctg aaacaagccg agcaattcat 2536381 ggaagacctt aagaaaaatc atcgaagtga agtcattaaa ttaatgtcaa gattagagac 2536441 agacgaacaa tcaaaggctg tcctgacaaa gcggcttctc ggcaattcaa cgtatttcac 2536501 tgagtatgaa attcaaggaa ttctcagcta tacattagat ttcgaagcat taaaaactgt 2536561 gtttacatct tcaccgatga agatactccc agctggcgga agtgcttctc gggagctttt 2536621 tccttatcgt tgcgcgaacg ccctagcgga acaattggaa acagaatggg ttgaattccc 2536681 cggaaatcat acggggtaca caatgtacca taaagaattt tctgagaggt tacacgacat 2536741 gttagaaaaa gaaaagaaac atacgtgtta aggattgatt aaaattttca aaataggaca 2536801 ggtgaaacta actatggaat tggagaagat ttcacgaagc gtaaaaagaa cttttcacta 2536861 acgagaacgc aatgtgagat gtttaaccaa agtgatatta gggatttcat cgaaaaatag 2536921 gtttgtacat tacgttctcc tattgattat ttcctatctt aattccgtat tttataccat 2536981 tagatacaac tctaaagcgg ctcgttattt tgtcctcaac aacaaccagt gtctaacatc 2537041 atgaatctct tttgaaaatc accacaaatg caggtatgga agacttcatc gcagcaaaaa 2537101 ccataccaac tattgttgtt ggtatggttc gtcctagata ggcccttaag aagagattct 2537161 attgtacgga gtatttagct aattgcattt gtaaccgaca gggccgtctg aacctgtgta 2537221 cacatatgtg tcagacacat atccaatatt cacgacaccc cgggaatctt tccactggat 2537281 ttggtcccag atattactcg ttccatactt ccctgtaaca gtcgttccat aagcgtaaca 2537341 ataataagga acacgggagc cactcggaat ggaaagcata ataggataat ttgtaccagg 2537401 accgctgcgc atattgacag gcgcaccgct gcttgttgag acagtaaagt actgaacggc 2537461 aagtgcctga ctggaaaaaa tgaataaaga tgcaatcatc acggttaaca tactcagcat 2537521 tttcagttta gtcaatgtca tccctctttc ttcaattcct tcattttaag aaacgataga 2537581 acataggcta ccagctgcat ttaggaacaa ccggaccgtc tgagcctgta tacatatatg 2537641 tatcagagac aaatccagga acgatctccc cgctggcaag cgtccgctct gtgtaattcc 2537701 aaatattgct cgttccatac tttccagtta cagttgtacc ggttttgtag caatagatcg 2537761 ggatgcgggt tccgctcgga atggtcgtta caattcccca acttgtacct gggccgctgc 2537821 gcatgttgac aggagcaccg ctgcttgttg aaaccgtata atactgagcc gcaagtgcat 2537881 ggctagaaaa aatgaacaca gatgcaatca tcaccgttag catacttagc ctctttaact 2537941 tattcacctt ataccctccc cttataaatg ccgtacgttt gactttctta catccagtta 2538001 aggatttact ttcagatacc atgccccctc ccctcccata tatttatcaa tgtaccataa 2538061 actagatctt tcaaaagtgg aattattcct atgttttcga caattaagga tacaaaataa 2538121 atggtagtca ggcttgatat tgatggtgtg ttacatttgg ctcttaatca tttgtccagt 2538181 cggtaatcac gattgacaat caggaaaaag gacatggatc aagcggcttc gtttccacca 2538241 attaactcaa tcagtgtact gcttccttgt atccacgctt cttctcgatt catagatact 2538301 ccaccttttt caccaatcaa aaacggacac catacaaatc agcgtaaatg ctgcaagttc 2538361 agtgtccgca acctattatg actttgcttt cttttaccag ggcgtgtaaa aatgattagg 2538421 tacgttatca aacgttattc tatgattttg cgagtcaaaa aatcataaca ttttatatat 2538481 ttcaatcaga ttatgatctg gatctctgaa gtgagcaact cgggcactcc attccttgcg 2538541 atcatgcggt ttattctcac atttaactcc tttttcgtgt aaatcgtcat acgttttatc 2538601 aacatcttct accttaaact gaagcaaaaa ttttgattga gcttctcctt ccaaggactt 2538661 tttttcctct ccaacgattt cagccatcgt ttctcgagat aaaagctcta ttttcgtttc 2538721 cccattatca aagagtgcat attccatttc attctctaac caacttattg gaagtcctaa 2538781 tgaatcttta taaaactcga cgcttttctt aaaatcattc accaacagtc taatttgtaa 2538841 cagcttcata tcgagtgcct cctataaaac catactttta ctggtcatcc aatttaatga 2538901 taccaaagaa acctgacagc actatgtcaa gtttccatac ttcaccctta tttcagattt 2538961 aagtgcagtt tagtccatgt cataagaacg agcaaaaaca gcgattctta aaacaaaaaa 2539021 tgataccgag tgtattttct gtatgcttca acttcatttc gggaaatgta acgttgataa 2539081 aaggaggtta catcaatatg gatcatcaaa cattggcagc tcatgaggct gttgacttac 2539141 atgaaatcgt gaactttaaa acactttgta tagcgaaatc aaagttaatg caagggcttg 2539201 tgtttgacca agaactgaag gacttgatgg aaaaagatgt acagcaatcc attcaagacc 2539261 ttactgaatt acaagcggtt tatgagcgtg cctcatttca ggcccctgtc cctcaaagcc 2539321 gcccaacgcc aatcatcaat tgaaagggag gtaagcctct ttgaataatg atcatttaga 2539381 ccccattaat tcgctgaatg tgcctgaact agcagacact acattcgcga tggattttct 2539441 tatacgagct aaggaaggcg taaggaatac tgctgtagct ttgacagaaa ccgcttcacc 2539501 agatgtaaga gcactgcttc ggaaacagct gatgcaagga attgcgatgc accaagagat 2539561 tacggaactg atgatcagca aaaagtggtt ccatccatat gagctgagcg aacagtataa 2539621 gctggatcag ctctctgcaa aaaacacgat catggtcggc aatatgaacc tctttcctga 2539681 tgaaacaaat cgcaaaggga tgtttgaccg gacacctgat gaacactaac actggaggtt 2539741 ttacagcatg aaggcagtaa cgtatcaagg cattaaaaat gttgttgtca aagatgtccc 2539801 cgatccaaag attgaaaaat ccgatgacat gattatcaaa gtcaccagta cagccatttg 2539861 cggatcagat ttacatttaa tccatggatt cattccgaat atgcaagaag actatgtcat 2539921 cggccatgaa ccgatgggaa tcgtcgaaga agttggttct ggggtgacta aactaaaaaa 2539981 gggagatcgg gtaattattc cctttaatat agcatgcggg gaatgctttt tttgtaaaaa 2540041 ccagctggaa agccaatgtg atcagtctaa tgacaatggg gaaatgggtg cttatttcgg 2540101 ctattcaggg caaactggcg gttatccagg cgggcaagct gaatatttaa gagtgccgtt 2540161 tgcgaatttt acccatttta aaatccctga atcttgtgag gaacccgatg agaaattaag 2540221 cgtgattgcc gatgccatga ccaccggctt ttggagtgtg gataatgccg gcgtaaaaaa 2540281 aggcgataca gttatcgttc tcggctgcgg accagtcggc ctgtttgctc aaaagttttg 2540341 ttggctaaaa ggcgcaaaac gcgtcatagc agttgactat gtaaactatc gcttacagca 2540401 tgcgaaacgt acaaacaaag tagaaatcgt taattttgaa gaccatgaga atacagggaa 2540461 ttatttaaag gaaatcacga aaggcggagc ggatgtagtc attgacgctg ttgggatgga 2540521 tggtaaaatg agcgatctcg agttccttgc cagcggctta aagcttcatg gcggaacgat 2540581 gagtgcattg gtcattgctt cccaagctgt tcgcaaagga ggaaccatac aaattacagg 2540641 tgtgtatgga ggcagatata acggttttcc gttaggagat attatgcagc gaaacgtcaa 2540701 tatacgctct ggacaggctc cagtgatcca ctatatgccg tacatgtttg aactagtatc 2540761 gacaggcaaa attgatccgg gagatgttgt cagccatgtc ctgccgctta gtgaagccaa 2540821 gcatggctat gacatttttg attcaaaaat ggatgattgt atcaaagttg tgttaaagcc 2540881 ttaaaaaacg gaggttacag aaatggaata cgccttacac gaagtgcttg aggttcagga 2540941 aatgactgca tttaagacac tttgtttgac gaaatctaaa acaatgaaag cactggtatc 2541001 tgatccgaag ctgaaagaaa tcatgcagca agatgttgat atcaccacac gccagttgca 2541061 ggaatttgcc tctattttat ctaatgcaaa gcaagaatga ggagatgaat aaatcatgaa 2541121 tcctatcata gaatatctga ctggcatgaa tgttctaaca gaccaaatca ttgctatgga 2541181 cttattaatt tcagcaaaga acggagtcag aaattatgcg atggcagcca ctgaagccgg 2541241 aacgcctgaa gtaaaagagg tccttatccg ccatttggaa gaagcactcg atatgcacga 2541301 acaactctca agctatatga tggaaaaagg ctggtaccat ccttggaacc ctgacgaaca 2541361 agtcaagctg aatttaaaaa atattgatac agccattcaa ttgccaaccc tttaacatac 2541421 aatgactgat ttgctgagga acagtattga ttggccacaa ctgttcctca gcttcaaaat 2541481 gagcactgtt tgttcgggtc ctatgaccgt aaatagatta accgcttttc tccatctgat 2541541 ctccgataat gtttgcaaat tctccaatcc aaataaggaa tcgtaaccac ctctttttat 2541601 gcgatctctt gatggagaaa acaggccaga aacaaaatcc ttcgtttttg acctgccctc 2541661 ttcacacgca aagaatgcta ccttctttgc tccactgatc cgtgaagact ttccgtttta 2541721 ggcctgcttt tgagctttgc ctcattttca cgcaatttcc catcataatc tttaattttt 2541781 gtgtctaatc tcttaattgt ttcatcaatt tctttccgct tctctatcag ccgctgtcgt 2541841 tcgtcagcca ggatattttt tcgagcttct accgtacggt caccttcggt aaataatgtt 2541901 gtatattcaa ttagcgcttc tatcgatagt cccgcatttc gcatgcattt aatgaattca 2541961 atccatttga tatcttcttc atcatagtcg cgaatgccgc tgtcttttcg ttttacaggc 2542021 gggattaatc ctacacgttc gtaatatcgg agtgttgcgg ctgtcaggcc aaactgcttt 2542081 gccacctgag caatattcat gatcttcacc tctctatcct gtatgttgtg aaggtaacac 2542141 ttaaagttaa ctttaagtca agctcaaaac aagtggttag ctgctgaatc tgggtttata 2542201 tattcgggac ttgccttaaa gcacacttta aactctatac ttctccatgc actaaaaaca 2542261 gtgtagttgg agggattgct gaatggcaaa taaacacact gccggaagag aacaattagg 2542321 agaatttgcg ccaaagtttg ctgaacttca tgatgatgtt ctattcggtg acatttgggc 2542381 aagagaagaa gaactttcat cccgggatcg cagcatgatt acagtttctg cattaattac 2542441 tgactgtttc tcagcttata aatcaggttc attttaaatg gtttttttaa aaaacccttg 2542501 ccttaaagca gactttaagg tttatcgtta tgttgaagac accataaaac ataaataagt 2542561 gcatgttttt atttacaaca cttatgatga agaaaggata ggttcgtatg tgtaatcaac 2542621 atcaaacccg tgtattaagc gtgtcacatg caaaagccaa atttgaacaa acgacgattg 2542681 agcgaagagg attacggccg cacgatgtct taatcgatat taaattcagc ggcatttgcc 2542741 attcagacat tcatagcgct tttgatgaat ggggcggtgg catcttccca atggtgcctg 2542801 gacatgaaat agccggtgtt gtaacagccg ttggaacaaa agtcaccaag ttggctgtcg 2542861 gggaccgcgt tggtgtcggc tgttttgttg actcttgcgg agaatgcgaa tactgtctca 2542921 acgcagagga acaattctgc acgaagggtg ttgttcaaac gtataactca gtagactacg 2542981 acggaaaccc cacttatggc gggtacagcc aaaaaatcgt tgtcactgac agatttgttg 2543041 ttcgcatacc agatcgtttg gaaatggatg ttgccagtcc gctgttgtgt gcaggtatca 2543101 caacgtattc cccgctgaaa cactggaatg ttggccctgg taaaaaggtt gcgattgtag 2543161 gcgtaggtgg ccttggacat ttggcaattc aatttgcaca tgcgatgggt gcagaagtaa 2543221 ccgtcctgag ccgttccatg aataagaaag aggaagctct ggaactcggt gcaaatcatt 2543281 actttgcaac aagtgaccca gccacattca ctgcattggc cgggcgtttt gacgtgatct 2543341 taaatacggt atcggcaaat ctcgatgtag atgcctattt atcaatgctt cgtatagacg 2543401 ggacacttgt aagcgttgga gctcctgcca agccggacac atacagtgtg ttttccctaa 2543461 tcatggggcg ccgcagcatt gcaggttctc tagtcggcgg aattcaagaa actcaagaga 2543521 tgctggattt cgcagctgag catggcatcg aacctaaaat cgaagtcatc ggagctgacc 2543581 aagtggacga ggcatacgaa cgtatcctcc gaagcgatgt ccgttatcga tttgtgattg 2543641 atatttccac attgtaatag gttagtcctt atatgggctg ccgcttttat tgaaactcac 2543701 gaaaaatgat ctctttaagc aaatattttg aaggccggtc aatcttcctg ttattctatg 2543761 aatagagagt tattaggagg gttttttatg agcaaaaaaa ttgcagttct tgttacagac 2543821 caattcgaag acatcgaata tacaagtccg gtaaaagcat acgaagaagc tggctacagt 2543881 gttgtggcta tcgatttgga agccggcaaa gaagttaccg gtaagcatgg cgagaaagta 2543941 aagattgaca aagccatctc tgatgtggat gcaagtgact ttgatgcact tttaattcct 2544001 gggggattct ctccggattt gcttcgtgca gatgaccgtc cgggtgaatt cgcaaaagca 2544061 tttgtcgaaa acaaaaaacc tgttttcgca atttgccacg gcccgcaagt actgattgat 2544121 acggatcttc taaaaggcaa agatatcaca ggctaccgca gcatccgcaa agatttaatc 2544181 aatgccggtg caaactacaa agatgcagaa gtagtcgtca gccacaacat tgtcacaagc 2544241 agaacacctg atgatttgga agcatttaac cgcgaatctt taaacttgtt aaaataacaa 2544301 gaaggcacag actgttcggg tctgtgcctt ttttaaaatt aagactcctt cgttacattc 2544361 tgaaagacag cagtcgcgtc ccacacattc aagccaaatt ggccttctga aaatacggaa 2544421 tcatgtgcat caatcacaag acgatcatct aaatagattt taaagcgatc gccctcggcc 2544481 tctgttttca gatgatactt tttattaacg tctatcggtg ttttgtattc agcaatgaca 2544541 gaagcagcac cgttctcaaa tttaaagaat ttcactaggt catgcttcgc atccacattg 2544601 gcaaggtaac cgtttttggc atctttgtca gagcgaaaca ttagtgctcc tgcccctctt 2544661 ccgtttccat ccttaatggt gatatcagat tcataagtga agtctgaccc ggatgctgaa 2544721 gacaagataa aggaatcgcc gtccgacctc ccttgtttcc cctcaattgt gtctgcccac 2544781 gtgccattta cagtcgtcca gccagtcata ttggacataa aaggtgtcgt tccccatacc 2544841 ttttttaaag ggtgtatcgt taaagatttt acctttacac cgccatttgc agcatataat 2544901 tcaagccctt tgcttgatcg gtctgggaga ataatatccg ttatgacctg ctttccgtca 2544961 ttcccaaata cttcaaccga ggagcggtca acaaaaatgc gcaacttaac cttcccattt 2545021 accggcttca acggggctgt ttcttttccg gtgttaaagg ccggattaaa ggtgtcgttg 2545081 cctgactcgc tccggtcaac gaacaatttg gcgttccttc ggtcatagcc gaccttcgta 2545141 aattgatttt cacctgttcg gaccttaaaa ccaaattcag cagctgaacc agggcttact 2545201 ttaaattctg catttatttc ataggcatct ccagattgcc ccgctaacac attatgactt 2545261 gcaggcgata tggtcagatt cttccacttc ttagaggttc cgcgaatggt ttccagctct 2545321 ttcaccggtg tttggaccac tctaacccct tcggtaaacg ctttcaattt taactctctt 2545381 ggaatggacg ttgcacttct ccatggggat gtcggaacat cattcgcata ttgccaattg 2545441 ctcatccacc ctaaccatag ccggcggctg tctgtggatg gaatatcaga ccaggataca 2545501 gccgcataaa agtctctgcc gtaatccgtc cagagaactt tgtttggcgg gttttcattt 2545561 ttaaaatgag ttccatcaaa gtcccctaca aaatattgca tgcctgatcc tcccgagacc 2545621 gctccgtttc cgacactgac ctgcatgacc catttctttt gattcggatt gccgtctacc 2545681 ggaagctcaa ataaatccgg gcattcccat actcccccgt ggcttccttg atcctgtcca 2545741 aattcacttg catacgtcca ctgcttcaga ttttttgatg tataaatgag gattcggtca 2545801 ccggccgcaa gcaccatcac ccactttttt tctttctcat accaaaagac ttttggatcg 2545861 cgaaaatctt ttttacccgg gtttggaatg acagggttgc cagcgtactt cgtccatgtt 2545921 cttcctttgt cgttgctata ggcaatactt tgcacttgat ggccttcccg atcctgtgta 2545981 taaatggcca caagcggctt ctctttgcct gtttgaaaac cgcttgtgtt atttttatct 2546041 acaactgcgc ttccagaaaa gatcgtgcct ttttcatccg gatacagcgc aacaggaagg 2546101 tgttcccatg taaccaaatc tttgctgacg gcatgccccc aatgcatggg cccccactga 2546161 agcccgtatg gatggtattg atagaacaag tgatattccc cagcataata taccattccg 2546221 tttgggtcat tcatccagtt tgcctccggt gtgaagtgat attgaggacg gtaatcctca 2546281 tcatagtagc ttgaatcggc tgcatctgcc gaaaatgcca tagtcaacag cagggtgaac 2546341 atgatcatga cttgaatcag tctctttttc atttgttcct tcgctcctct cttcatgttt 2546401 gaacactttc aaaagagact gctgcgcaag ctggtccgtt tctggcaatt ctcctctgtt 2546461 tcactgttat ccgaatgatt tatatatgaa aagactgctg cagtttctct ctctttcctt 2546521 cacacacctt atgctaagaa tccagcccaa tacccgagaa tcccgatgac aaagatgccg 2546581 caaataatga gaagtggatt cacccctttg cgaagcatcc atgccaccaa taacgttaat 2546641 ccgagaggca gcgcccccgg cataatgcta tctagcacgt tttgtaccgt ttgaacatct 2546701 acttttccgc tttcatcctt aatcctggat acaacgattg gaatgttgat ggtggtccat 2546761 ttggacacga gagcccccat aacaaataac ccgagaatcg aagcgccctc tgtaagcttt 2546821 tgaatgcgat tccccgctaa atcctgaaga atctccattc ctttcacata gccatacttt 2546881 aatccgtaat attttgtgct taatcttatg gcattcagca agaaaaagaa tagcaaagga 2546941 ccggcaatgt ttcctcctaa agcaagggag gctcctagcg cagctaagac aggacgaatc 2547001 gttccccaaa aaattggatc gcctacgccc gctattggtc ccatcaaacc gattttcatt 2547061 ccgcttatcg cttttccgtc aattccttta ttgttcgcca tttcttcttc catggctgcc 2547121 gtcacgccaa atataggcgc tgtcagccac ggatgtgtat taaaccattc caaatgccgc 2547181 tgtaaggctt cgtttctttt cgctccggga ccgtacaatt ttttgatcgc cggtatcatg 2547241 acataacaat atcccattgc ctgcacacgt tcgaagttaa aggaaccgag taaaaaattt 2547301 gaacgaataa acatgctgaa aatttctttc ttcgttaatc gtttttcttt ctccattttt 2547361 tcttccccct catcgtttag gcatcaagat catcatcatc gtcatcataa acagcaacac 2547421 tgccactgtc tgatgcggcc gcgactgctc cgtgagcgct ttgtttttgc atcacctgct 2547481 ggtataaaag cgccagacag agaccaaggg ctccaaatcc cactaagtta aaatcggtaa 2547541 acgccgctaa taagaaacca atatagaaaa atggctttaa ataaggaata ttcatcatat 2547601 tgatcaccat ggcatacccg acaaccacaa taatgcctcc gcctatttgc agtccttttg 2547661 taatgacatc aggaatattt cccaggaacg cctgaacagc gctgacacta attaaagcaa 2547721 caatcaatgt aggaatcatg acgcgcaaag cttgaaacac catcgcggta atatgcataa 2547781 tttcaattcc ttttatattt cccgcttttg catattgatc agcgcggtgg atgaaaaaga 2547841 cagtgatcgt ccgaacaaaa atcgtcagcg cctgacccgc agctgctaaa gcaacagcga 2547901 cagcaatccc ttcgccaatt ccttgatcag cggtaataac taaaatggtt gagatgacag 2547961 aggcgatcgc tgtatcaggt gccatggcaa gcccgacgtt catccagccg agcgccatca 2548021 gctccagtgt gcctccaaga ataattcccg tttttaagtc cccgagcacc aagccaacca 2548081 acgtacaggc cactagcggc cggtgtgtct gcccttcatc caatacactt gcgattccgg 2548141 tgattgctgc aatgattaac aacaaaataa tttgtaatga agacatattc tcatcccctt 2548201 gattattttg ttacgttccg taaaatctgt acaaaatcct cactggcatc tgaaggcagc 2548261 tgcctcaatt ccagtttcac gcccttgtca cttaatgttt caaatgcctt tatatcttgt 2548321 tctgtgacac tgactgattt tgtgatttgc ctgcgatgat tttcaaaacg cattcccccg 2548381 acgtttacgg ttttgatcgg tacacctgct tctataagag atacaatatc ggacggattt 2548441 tcaaacaaga gcattgccgt taccccttcg tagcgcggac tatgaaatgc ttttgccatt 2548501 ttagaaaccg agacggcact cgcctttaca tttgaaggcg caacagaaag gatcagcgtt 2548561 tttctcattt cgtcctgagc aatatcgtcg gagacaacga tgattcggtc ggctgcatgg 2548621 acttttatcc accttgtcag gatttggccg tgaataaagc ggtcatcaat tcttgctaac 2548681 acaatgttca tcataattca tcctctcttg tatcttgatt ggctgttttt actttttcta 2548741 aatgttcact gcacacttga aagctttgct gactcattgc ttttaagttg ttcagcaaat 2548801 ctttgagagc cagatgttct ctcaggctta atacctccag cagaatcggc aggtttacgc 2548861 cggcagccat atccattctt tgatcctcag caataaagga agctgccgcg ttatatggcg 2548921 tccctccaaa aatatcgact aaaaaaagca cttcatgttc ttccgggata tccttgagcg 2548981 cctgatgata tttttcttgc agcgtttgta ttccttcccc tttgaaaaac ggcactgcaa 2549041 tcaggttatt ttcttcaccg aatatcatcc ctgaagactc ttttaatgct atgggaaaat 2549101 ctccatgacc gctgataata actgaaatca tatctattgc tcctttcctg ttttgtacat 2549161 ccatatataa tgcaaggatc gtgccaacac agttgtgtta agcgttttca ttgttatttc 2549221 agccaatagc aatttgttgt tgaaacactt aaaacgaaaa aaataaacct gtattaaaat 2549281 ggtgttccat ttaatacagg ttcatatgaa aaaactgttt ttaaaacagc tggccatgca 2549341 cttcttcagc aaatatggcg gctataaata atttttcatc atcacttatg cgaagtccga 2549401 gcttttcttc ataaggggct aatgttcgct ctgtcacgta caccatttcc ttcagctgat 2549461 cattgatctc ttcttcctct gagaaagcga tcggattctg cttaattacc ctttcaaagg 2549521 cgaaagccgt gtgcataatg actttgatca aaaccgcatt attgaaaatg acccccagct 2549581 catcctgaac ggtttgcagc cactccaata acatgtcgat cacatggtgg ggattcaaga 2549641 agacaaggta ttttttcagg ctatcctcgc aaagctccct gacaataata tttgcttcgt 2549701 tcaatccatt gctcaaggag atgcttcctt ttgtaatcgc ctgttgaatc agcttctctc 2549761 cctccccttc aattaacact tctaaagata catgcggagc attgatttta gggtctttcg 2549821 ttccgactgt cgcaaggatt tcatactctt tttcgatttc ttttatgctg ttggccagct 2549881 taatcgatga tacggtcaat atgtgaatgg gggtatcgga ggccttgttt acgatcgtgg 2549941 ttagaatgtc ttccagcttt ttggccgttc cgctacccgt cgtgcagatg gataccaatg 2550001 ccttcttttt gccggatgcc gctggctgac gctcccacaa ctcgataaaa tccttcgtga 2550061 ccgattgata gatcgcatgc aaatttaaat tcaaatagtt gacctttctg acagcatcca 2550121 gcaccattga agtcgtaaca ttgctgatcg ttttaataga aatgcctgtc ttttcctcca 2550181 gcctgctttc cagcattgca agcgacccca tatctaccag cattaaaaca ccttcacctt 2550241 catcaacctg tttcattttt tctgctacgc attcaagaat gtccgaaggt gaaacagtaa 2550301 gcggcatgtc aactgctgca atcggcgtac tccctagcag ttctgtcgcg acttcaacca 2550361 ttgaactcgc cgtgctgttt ccatgagctg ccacgataat accgactctt ttgttctcct 2550421 ttaacgattt gatggaatga attaacatcg ttaagtagat gacttctatt tcaggaatag 2550481 ccactttaaa atattcctga attttatctt taaaaatcat cgccacccga tattctttca 2550541 catgggtatc acgaatttca tctgtctcct gtgtattcaa aacatcaatt tgctttcctc 2550601 gctttaaaaa tgcgtcaata tgcatactca agaaataaat aaacttacgg tcaaatgtgc 2550661 aatccagctc atgttcagct atttctttta actgttttgt catttgaatc acatcgtctt 2550721 caacgaatgt cagcaggttg tctttttgaa aagcttgatg atgaaaaaaa cttctgacat 2550781 gcaaatggac atcagtcaag atgtactggt taatatcctt tttggataaa ccttctttca 2550841 taagcgtttt cactttttcc tcaatcaaat gatataagtt aaatgagagg tcttcgtcaa 2550901 tttttgttgt ttcatcttct acaatcggag agataatcgt tgtaatattg acatattcag 2550961 aaatggcttt gcttctttgc atgtttttgc tgctggacat ccattcttgc ttgatttcat 2551021 caggcagatc gcgaacagtc agttcaataa cttcatttct gtcaaggtta tgcaaaaatc 2551081 cgtgtgcgca aactaactga acatttgatt tcagctgtcc gacattccca aatttcgcag 2551141 agtgaataag cgcattatag acatcgatat gcacactcag attcttctta attcgctctg 2551201 cttctttccc taataaaaac gtcgtcagat ccactctttc attaagcgat cgttcttcaa 2551261 gcgaaggaat atgaatggtc attgggattc ttcgcaaaaa cgttttcaat agtgcagaac 2551321 tcggattttc tgtagtcgca caaataaaca atacgttcga tgttcgttta tgttcagatt 2551381 ctccaagcct gttataagaa ccgctgtcaa taaaataaaa cagcatttct tgtccctcgg 2551441 gagggagacg gtggatttca tccataaaaa gaatgccccc attggcctgt tcgactaaac 2551501 ccgccttatc ctcggcagca cctgtaaatg aacctttttt gtgtccgaat aattgagaaa 2551561 gcaataattg agggttgttg tagtagtctg cacagttaaa tgtaataaat ggtgcgccgg 2551621 ccttcaatat gtcagagtaa atggcaaact ggtaaattcg gttcgcaaaa agggatttac 2551681 cggaaccagt cggccctagg aggagcatat gcagaccgtt cggcggataa aagacagctg 2551741 cttttgcctg ggagatcgct ttcttcaaac tcccttttgc ccctatcata agctctaggg 2551801 gattcgtgga aatgtgttga tgattttgct ttgaatttcc ggaaaacgcc tgaaggtctt 2551861 tcacttccat catctctgta tcccatttct tgttgaataa tttttctgct atctcgactg 2551921 ggatgtatct tacaggaaat gttttaattt tgatgacctt tttggaccgg acgagattgt 2551981 tcaattcaaa gctgacattg gaccgctcca ttttcagctg ctcggcaatc tcctttgctg 2552041 aattcccttg tatttttaaa agatgatcta aggttgaatc atgaaaatta tgcttgagct 2552101 gatggtatat tttatctatt cttctcacgt ctatcatcct ttgtccttat tagataagcc 2552161 attaacaaga atatttcgaa actttatagt ccgcgttgag atttacacgt ttaaaaaggt 2552221 ctctatagca gattgacaaa gctggctttt atgcgtatat gtttacatgt tgaatcattt 2552281 gcacctcata ttagtatgat agatgctcag ttctggaggg ccagtcccct tcaaaagtaa 2552341 taatcagtaa acagtttatc attctcgggg aatgtaatga tgtcaaaata atcaatgaca 2552401 aaaaatgaat cttatagatc atgacaaatt acccaaatat aaccccttaa gttcgttcac 2552461 aactaaaaag acggacactc tatgtgaccg ccacagtatt acaatttgca aaacttcgtc 2552521 atttttgcaa tccacattgg aggttaagga atctgtaagc ttaaaaactt tatctccgat 2552581 cctatcgatt tgatccccct gccggcctca atcatagtgg gtatgcaatt atacaaatcg 2552641 ttaccgatta aaactagcct gtcagattgt ccaaatgact ttcctgtttt actctgctat 2552701 tcaggtagaa tcacgagtga aaaatagagc cacaagacat gtaacagcac ttaaaatagt 2552761 tttaaaattt aaaaataaaa gtatctattc ttttaaatgt tataatatcc gataaaactt 2552821 tactcatctt tttattactg gaggaaaata aaattgatag gcaattctag caaagacaat 2552881 tttggccagc aacagaaatt gtctagaggc cttaaaaaca ggcatataca attaatggcg 2552941 attggaggtg caatcggtac aggtttattt ttaggttcag gtaaatccat ccattttgca 2553001 ggaccatcca ttttatttgc ttacttgatc accggcgtat tttgcttttt cattatgcgt 2553061 tcgctcggag aactgctctt atcaaatgcg ggataccact cttttgttga ttttgtaagg 2553121 gactatttag gaaacatggc agcatttatc actgggtgga cctactggtt ctgttggatt 2553181 tccctcgcga tggctgattt aacggcggtc ggcatttata cgcaatattg gcttcccgat 2553241 gtgcctcaat ggctgccggg tcttcttgcg cttattatcc tgctgatcat gaaccttgcc 2553301 accgttaaac ttttcggaga attagaattt tggtttgcat tgatcaaagt cattgccata 2553361 ctggctctga tcgtaactgg tattctcctg attgcgaaag gtttttccgc agcttccggc 2553421 cctgccagcc tcaacaacct ttggagccac ggcggcatgt tcccaaatgg atggcatggg 2553481 tttatcctat ctttccaaat ggtcgtcttc gctttcgtgg gtattgaact tgttggactg 2553541 acagcaggtg aaacagaaaa tccccaaaaa gtgatcccta aagccatcaa tcaaattcct 2553601 gtccggattt tactttttta tgttggcgca cttttcgtga ttatgtgtat ctatccttgg 2553661 aatgtgttga atccaaacga aagcccattt gttcaggtct tctctgcagt aggcatcgtt 2553721 gtggctgcca gtttgatcaa ttttgttgta ttaacatcag ccgcatcagc tgcaaatagc 2553781 gctttattca gcacaagccg aatggtctat tcacttgcaa aggatcatca cgcacctgga 2553841 ctattaaaga aattaacttc ttctaacgtg ccaagcaatg cgctgttctt ttcatccatc 2553901 gccattctga ttggcgttag tctgaattat ttaatgcccg agcaagtctt cacgctgatt 2553961 acaagtgttt caacaatatg cttcattttt atttggggca tcacggtgat ttgccatttg 2554021 aaatatcgaa aaacaaggca gcatgaagcg aaagcaaaca aatttaaaat gcctttttac 2554081 ccattatcca actatttaac acttgcattt ctcgcgttca ttcttgtcat attggcactg 2554141 gcgaatgata cacgtattgc tttgtttgtc accccggtct ggtttgtttt attgattatt 2554201 ttgtataagg tgcaaacccg cagaggacat aaggtgaaat aaaaaaaaga caagggatac 2554261 tcactccctt gtctttttat atgtgtcaaa cactaaatta aactttggtt tcaaatttca 2554321 ttcacttcat ttaagtgtta actcaaacca gttttgatgc cgaaacctac taatattatt 2554381 ccggtaattt tttgaaacac tttctggaac ttcgagtttt tcatccattt ttttgcgtaa 2554441 tcaataatat aaacaagaaa caggaaccac aacaccgcta ataaggttag gattgaagct 2554501 aaaatgatga gctgctggtt tatatttccg ttcaaattga taaattgggg catgattgta 2554561 acatacacca aaacagtttt aggattgaga atgttactga gtgatccctg cataaaggaa 2554621 gttttataat aacgtttcgg agaacttgcc atattttttg cttgggattg catgtcatct 2554681 aacgaaaaca tacttttagc aaaaaaactt tttacaccta aataaattaa gtatgccgct 2554741 cccaaatatt tgatcgttgt gaaaagaatc actgactttg cgattaccac tgataatcct 2554801 aaaatggcaa tcaccgtcca aaaggaaagt cctgtcgcca atccgagaat gttataacgg 2554861 ccggctttcg gaccatacct aagcgtattt ttcatcacaa gcatcgtatc tgcccccggt 2554921 atgataacca tcatggcagc gatcggtatg tatgcgagta agctgtgcat tgttctctcc 2554981 ccctttaaaa atcccctcaa tcatatagtg actacaaaag taactactta taaaagtgta 2555041 tcaatgcgtt tggaataaat caatatgatt tgttaaaata gcgattacta aggcagcgat 2555101 tgctctttat attggaggat atatgaaaga aaatatgtta gacattttaa aaaacctcaa 2555161 ttttacagaa tatgaatcga aagcgtattt agcattattg caagaatcac ctttaacagg 2555221 ctatgccgtt gccaaaaaat ccggagtgcc ccgttctaaa atttatgaag tattggaaag 2555281 tcttgtcata aggggagatg tttttgtcag tcatggaaat acgcctcagt atgttccagt 2555341 ccccgcaaaa gaactgatta aaaaccgccg gctcaaagcg gaagagcatt ttgatcaggc 2555401 tgagaaatat tttgaaaagt tcgagcagac cgcaaatgac cgggaaaaca tctggaatat 2555461 caccggccgc agtgaaattc ttgaaaaggt gaaggcttgt atcttatctg ccaaaaaaag 2555521 aatcctctta gaaatatgga aagaggattt taaggagata gaagcagagc tcaaacaggc 2555581 ggcagaacaa ggcgttattg tcaccattat tgcgtacgga gacatcgtat ctgattttgc 2555641 caatgtttac cttcatgata tgagcagtga aattacagaa gagtatgacg gacggtggct 2555701 tgtctatagc ggagatgatt cagaagtagt agcgggcatt gtctcacttg gcaacgacag 2555761 ccgtgctgca tggacgatgc atgtagggtt agtcatgcct attactgaag tgatcattca 2555821 tgatctgtac ctcatggaaa ttctgaaaaa gcatagagag cttttagaag agagcttcgg 2555881 gaaaaatctc atccagttgc gccgtaaatt ttctattcac tcagatttca aaaaacatta 2555941 tttggaataa tgtttgtcat ctcttacccc aaaaacaagg cttgtacaaa acaagccttg 2556001 tttttttatg cataaacccc ccatgctgat ttacttctct cttttaaaaa atgtgattct 2556061 gcgcaaacta tttttcagcc tgccgcgtct atcctaggta acagcctacg atatacgtat 2556121 attcaaaaag gagcccttta ttgcaatgaa gaaaaaacaa acaacaaaag cgttgcttgt 2556181 cacatgcata actgaccata agcaagattt ctacaggttg gctttcagtt atgtgaaaaa 2556241 tcaagatgac gcattagata ttgttcagga atctataaaa aaagcgctga gctcagttga 2556301 aacggtcagg aaccctgaga cgataaaaag ctggttttat aaaattttag tacggacagc 2556361 cattgacttt ttgcgcaaac aaaaaaagat aagagtgatg gacgacgaaa cgatagaatt 2556421 tttaagcaaa ggaaaggaag accattacaa ggatactgat ctccatgaag cgcttgacga 2556481 attgccgtac cgctataaaa ccattattat tttacgtttt tttgaagacc tcaaattaga 2556541 agaaattgcg gaaattacag gagaaaacac gaataccgtc aaaacgcgcc tatacagagc 2556601 attgaagctg atgcgcattc agttgacgaa ggaggatctt tcttaatgga taagagatta 2556661 cagcaattaa gagaagaata taaaaatgtt cagattccta aagaattgga tatcattgtt 2556721 gaaaaagccc ttcagcaaga accaaaaaag aaaagaatcg ttatgtggcc gacatcagca 2556781 gcaatcgctg cagctatttt attcactgcg cttgttaata tcaacccgga cgccgctcag 2556841 gctatgtcaa agatccctgt catcggcaaa atcgtcaaag cgatcacctt tattgaaatc 2556901 aaagaggaaa aagaccaatc aagcattgat gtcaaaacac ctgctttgtc cgggctttct 2556961 aataaagagc ttgaaaacag cattaacgag aaatacttga aagaaagcca gcagctgtat 2557021 aaagagttta tacagtccac atccaaaaac aaaaaagggc atctcagcat ctacagtgat 2557081 tacgagacgg tcacagacac gccagattta ctctctatcc ggcgcaatat tgaaacaaca 2557141 caagcatctt cctacacaca aagccgttat attacaattg acaaaaagaa tgatatttta 2557201 cttacattaa aaagcttatt caaagatgag cgctatatca aagtcatcag tcaaaacatc 2557261 aaagaacaaa tgaaacagca aatgaaggaa gatccaaata aaatatattg gctcactgac 2557321 gaagatgcag aaccgttcaa aacgattctt cctgatcaga cgttttacat tactgaagac 2557381 cataaacttg tgatctcatt tgacgaatat gaagtcgccc ccggctatat gggcgttaca 2557441 gagtttacaa ttccaaccgg cgtcatttca aacttgctcg tgggagaacg ttatattcga 2557501 taaaataaaa acatccatct aagattatgg atgttttctc tcttctctat tcgaggtcgt 2557561 aaccccgcta tcaaaaacaa cgagaatatt tgcatactat tggaggaata cccatgtatc 2557621 acaagacaca gcatcatcga tacattcctg gacttgatgg ccttcgggct ttcgccgtcc 2557681 tgtcagttat cacttatcac ctaaatttca attgggctaa cggtggtttt atcggggttg 2557741 atatcttttt tgttttatcc ggatatttga ttacatctat tctattaccg gcatatggaa 2557801 atgatatcaa tcttgatttt cgggattttt gggtgcgccg cattcggcgg cttctcccgg 2557861 cagcgtacct tatgatcttt tccactgttg tgtgggtcgt attgtttgat cgagaactat 2557921 tgcacactgt acgtggagat gcgatctctt ctctctttta tatgagcaat tggtggttta 2557981 tttttcacaa gctatcatat tttgatagtt tcggttcccc atcacctcta aaaaaccttt 2558041 ggtcgctggc gattgaagaa caattttata tcatatggcc gatgttttta gttgttggaa 2558101 tgtacataat gaaaagccgc gccagattgg ctgcggtgat atcattgctt gtgctttgtt 2558161 cagccgtgat gatgagcgta ctgtatgaac ctggcggaga tccgagccgc gtttactatg 2558221 gcacagacac tcgttcgttt gaacttctca tcggatgtgc cttggctttg gtatggccga 2558281 tgaaaaggct gtcttccaac aggctgccaa gcaaactgaa gcacactttg cacgccactg 2558341 aatttttggc attttgtatt ttagtgttgt gtgtctattt cacagatgaa tacgagcctt 2558401 ttctttacag aggcggaatg ctattcatta gcgtgactgc cgcaatcctt attgcatgtg 2558461 tttgccatcc gagcagcttt ttaggcaatc tgctttcatg gaggccgctt cggtggcttg 2558521 gaacgaggtc ttacggaatt tatctttggc actaccctgt tattgtgtta agcacgccag 2558581 ttcaagaaat cggaaaccct gttttttggc atatcgtgct aaaggtcatt gtgacatgta 2558641 tacttgccga gctctcctac cattttattg agaagccgat acggacacag ggatttaggt 2558701 cattttcccg ccgtgttttt atacatagaa tcaaggaatg gaaaacgaca tctgtcatca 2558761 gcaaaatgtc aattggtttc attattttcg ctatacttat ttttgcaggc gggctgtcag 2558821 ggctagccgg cgagcaaaag caccctacca aatggaccta tagctcacaa gaaacaaatg 2558881 ctgacaccag ccaggcttct ggggataaaa agaacgctgc agcagataaa aaacacaatc 2558941 ctgaacaaaa gacaacagat tccaatcagg gtcaaaagga aaacaaagat agtgggcaag 2559001 agactcataa aaagaaagac acgcaatccc aacagttgaa aaaaccagca gacactgcga 2559061 aagaagtttt agctatagga gattccgtca tgcttgatat ttcttcacac ctgcgtcagt 2559121 cattttcaaa tgtgacgatt gatggaaagg tagggagaca aatgtctcaa gctttggaac 2559181 tcgcaaggga atacaagtct tttaatcagc cgaacaaggc tgtcatcatt gagcttggaa 2559241 ccaatggcta ttttacaaac agccaaatcg aacaactgct tcaatctttc tcaaaagctc 2559301 atatttatct tgtcaataca cgggttcccc gccaatggga aagcaaggta aatgaatctt 2559361 tgcagcaaca ggcccacgca catcaaaatg ttacgttagt tgactggcat acagaagctc 2559421 ttcagcatcc ggaatatttt acccctgatg gtgttcactt ggttcctaaa ggggcaaaaa 2559481 ctttgactgc tcttattgtt caggcgatga aatcgtaaaa aagagatcct atacagatca 2559541 cttttttact ttagtttctg atcgttgatt atgtcttctt tcagcaaggc agcccttatg 2559601 tttacatgcc gtttacgtaa gggtaagcca aaattgaatg gagggatgat aatgaaagga 2559661 aatgaagaac atgacatcca aaaagagttg aaacgatatg agcttttttt caaaaaacga 2559721 tataaggttc tttatacagt aaacgatttt atcatcggtg ctatgtttct cgttggaagt 2559781 tttttctttt tttatgaccg gttaatgtcg gcagggatat ggctgtttgc gatcggaagt 2559841 ttgctgctgt taatcaggcc gaccattcgg ctgattcatg actttcatta ccgtaagcat 2559901 gtggaacagc aattcaagca tcaatcttca acagatgact gatcttaagg aataagaaag 2559961 aacaaaatgc caaaagcctg agtcgaaaat caaaaacaag actttcagac tatttatttt 2560021 taaaaacaag gtaaaaagaa ctaaactttt gcctctgcat gccgatatga ataataaggc 2560081 cggcgcgata ctccctataa catccttttc agtagatttc attatcgtgc cggttttctc 2560141 atatgcaaag caatcccgcc aatcagattg gcgggatttt atattttaca ttcctgtcca 2560201 aacgtctttc acataacgtc tttgatcttg cagcttttgc agccatacag ctgattcttc 2560261 ctgacttgct gctttttcag cttcatatgc caatcgcaaa gttctctcta catcaggagc 2560321 catttgcgat ccatcaccgc atacgtaaat atgagcccct ttttcaatga gtgtcatcaa 2560381 tttctgcgta tcttgcttga gcaagtgctg gacatatcct tttggttcgt tttcgacgcg 2560441 cgagtagcat cggcggattg tgaccaaacc gtcctgttcc gcttgatcca gctcttctct 2560501 gtaaaggtcg tcatggtccg ggcggcggca gccgaagtat aaaagtgctt caccaagggt 2560561 gcttccttcc ttcttcaaaa ccgatcttgc ctgaataaag cctctgaatg gcgcaattcc 2560621 tgtgcccggc ccgaccataa tcataggcgt ttcaggatca ttcggcatct gaaatccgga 2560681 ctgcggcgta cgaatgaagc aagctgctgc atcacctgta ttcaattctg ctaaataatt 2560741 agaggcgaca ccccggtatt cacctcggcc gctccatgct gaggctttca caactcctac 2560801 cgtcatgctc acgatatttg catgaacttt cggtgagctt gaaatggaat agtatctcgg 2560861 ttttagtgat ggcaaaagtg ctaaaaaccg ttcaaacggc atttcgcaag caggataatc 2560921 ctctaaaaaa tcaagcatgg taagacgttt tgcaagtacc tgctctttgt aaatgccatc 2560981 atctgaaacg agctgttcca gctctttttg atgcggcgga caaactgtat aagaggccag 2561041 ctcccgaagc tgaagccttg atgccggttc ctgcagctct acataggacg acaataaatc 2561101 cactactttg attggccgat ccatcggcag atgagccata tgagcgcttc cgcttacttt 2561161 tatcacatga ttggactgca aaccgaatcg gctgagaacc cgctgaacaa gctccctgct 2561221 gttctttggc aggattccga tatgatcgcc ttctttatat gttttaccag ccggaatttc 2561281 caattcaata tggcgggttg aacgcgtgct ggcagctgtc tggagttctc gattctctaa 2561341 cacaatccct tcaaacgcgc catatgcttt agcaaccggc gtttccgtcg cttcactgag 2561401 aaaagtaatc gataatgaag gcctgtcttc tttctgggct atttcgttaa tatcaaatgc 2561461 gtccatcgtt tccttccaga agcggttttc ccaagactcg cggtggcttt caaaatcatc 2561521 ggcggcgtca ccttccccaa tcgctgttaa acgcgatgcc ccctttgctt tcatcatgtc 2561581 atcaatcagg cggggaatcc gctgatacgt gctggcccag ctccggtttc cgcagccgaa 2561641 taccgcatag gaaacacctt tcaattggcc ttcctcaagc tctttcagcc actctacaaa 2561701 tccggcagca ttatcaggcg gcgccccatt ataagaagcc gttacaatga cgactgcccc 2561761 ttcttcaggg agcttgccga tataatcatc aagcggagcc gtttcagctg taaagcccat 2561821 ctggcggcct tgagcagcca gttcaccggc tattccctca gctgtcccaa gatttgaacc 2561881 aaaaagaaca agtaaaggtg tgccgtgttt aggtttggtt tcttttggct ttgtttctgc 2561941 tttgatgtct gcctgttctt ttctctgtac attgattgcc gctgtttttc gcggtttcac 2562001 agtaatttta aaatcatccg gcttgatcgt taatgcttct ttgattttta gttcgtagcc 2562061 agtatggttt atcaattcaa aatgctttaa tacaagaccg agaaccattg tcgcttcttg 2562121 aagagcaaac tgcatgccaa tacaagcgcg ctgtccgttt ccaaacggct tatacgcatg 2562181 gtgagggata cttgaaggat cctcaaaccg ttccggacgg aaatcttccg catccggtcc 2562241 ccaagcgttt tgatcccggt gcagttttgg aattaaaaca gtgactggct gccctttgct 2562301 gatcggatat tccccgccta gaacagtatc ctccttcgca tatagagaaa aagccggagc 2562361 tgttggatac agtctgaggg tttcatttaa aaccatccga atgtatttga gctgctggat 2562421 ttgtttatat tcaggcgtgt catccgttaa cacgcgatcc gcttcctcct gagctttttt 2562481 cagtttttcc ggatgtgtaa gcagacaata aatcgcaaag gatagcaacc cgcttgttgt 2562541 ctcatgtcca gcaattaaaa atgtgatgat ttggtatcga atgttttcgt catccagcgt 2562601 ttcacccgtt actggatctt tggcataaag catgagagac aagagatcct taatgttttc 2562661 atccggattc gcctttcgct ccgctatcat tctatcaacc agggagttca tgacttctat 2562721 atccttttgg aactgcagct tcgttttcac catcatttta tcttgcaggc ccagtctttt 2562781 cgattgattc atcgcctctt ttaaggcacg gagcatactg gtgataaacg gatgctgtga 2562841 atcacggtaa aagctgttga atcgatagtt aaacccgcat aacccaatcg tatcaagcgt 2562901 cagacgtgtc atatcgtccg ctacatcaat ttcttcatta gggtttaacc ggctccactt 2562961 ttgaatcagc tgggttgcga tatccagcat catagaatga tagcctttca tcgctttttg 2563021 actaaaactc ggcagcaaaa tgcggtgggc tttttgccag ttcggttcgt gcgtccagct 2563081 tgtaaataag ccatctcccc cgaactcacg caccttttgc aagcctttgc caaggttctt 2563141 gtcaaagcgt ttttcatcac acacttcagc cacaagattg tggccggaca caaaaacact 2563201 ggatactccc ggaaaatcaa aacggaaaat cggtcccaat tcatcagcta tccgccataa 2563261 ggattgagaa agctgttctt tttccagatg cggaagattt tttaaaggtc cgtatgtttt 2563321 gggctgaggt attgcgcttg cctgtttcat taacatctcc ctttcctatt tttgtgatga 2563381 atgaagctta atggcgtccc agcagcattg ttccaattca gtaattaaat cagtgtccat 2563441 ctctatatca cctgtttgaa cgagctgata tatcttgaga aacgccccta atacaatcgc 2563501 aattaacaca ttagagggca ggctgcgaat cacgccttcc gcttttccct tattaaaata 2563561 gtcatcaagc atttgagtca gattttctat catttttttg cttgtatgat ttaagtaatg 2563621 agcgtctttt ttggtttcaa gaaaaaaaag cgcatagtcg ctctctttcg taaactgaac 2563681 gagacagcaa aatacgtggt gaaagccttc tctgacaggc aattctgaaa cgtcttgctt 2563741 cagtttttcc gtaaatcgct ggatgctttc ttgaaacagt acgttaacga gtgtttcttt 2563801 gctgtcaaaa taacgataga tcgttcctgt ccctacatga gcacgttcag ctatcatagg 2563861 aatagtggta gcgtcaaaac ccctttccgt aaaaagtgag actgacgctt tcataatcat 2563921 gtcgtattta ctgctggatg cggatatcat gtaatctgac aacctccgat tcgtttacgg 2563981 aatgaatatt cattcctttt gttcacaaag aatgtctgcc ctgtctgata tcacctcttt 2564041 gttctttctt ctgttataag tttatatgaa aaaaactttt tttaatataa agtatatgca 2564101 aaaaataaaa aattaagaaa atatacccaa atcctaatac gaggatcttg gatatatttc 2564161 ccgagaaatt ttttatttaa cagccacaat acatagacag gaagcacgcc tgataacaga 2564221 aagatccctg aaatgctggt ctttcagcag ttgaatatac gttttctctt tttcaccggt 2564281 atttgtgtca atactgatat aaaaccggcc gtcaatttga agcaccctgt aaatttctct 2564341 taatgcaagc ctaatatcgg tgcagctttg aaccgtatgt aaagaaaaga ctttattaaa 2564401 ggtacggtca tcaaagggaa tgtcctctgg atagccatga aaaacctccc cgttccccat 2564461 gttctttcga ttcgcacgtg atatctgtct tacctttcgt tttgaaggat caatgctttt 2564521 taggctaccc ttttttagtt tcttggttat gcttttaaag acagtgccgt ttccaattcc 2564581 aatttctaaa attctgtcat tttcttgtat atctatagag tcaatcatca tatgctcaat 2564641 tgttttggtt agcttatatt tccgagaaaa taatttccaa aaatccgatc gtttatagag 2564701 tctattttct agcattttaa acacctgctt ttggtttcct atgtttattt attatcttaa 2564761 aaaaataaac atcatcttca tttctaaaag tgaaggaagg taccaactag acggcaatgt 2564821 attgaaaaat gtttcaatag aactaaactt tttcattttt ttccgaaaaa aaagcagaaa 2564881 acataatgtt ttctgccctc tttctaatgc caatgataag ggaatacata cagcctttgc 2564941 tgctgcattg ccatcagcct ctgctgtcgg aatggatttc cataaccatg tttgaaggaa 2565001 tgcggcatgg acgcataacc atggccaatc gacggcagtc ttttttgata atcgttcatc 2565061 atgccatcac ctgcctcaca ataacgttga tttactatat gcaggcgcgc attttcttga 2565121 cagctatttc gctaaacttg gtccttctcc attgtataat gcatcaatag ttccattcta 2565181 agcatatgcc attccccctt cagttttttt cgttgctttt agcgccagtt tgttaaataa 2565241 agatgcttta actgagactc tttcatttca tcataaattt gttcaatctg ctgttctcgt 2565301 tcgaattctt ccaggctttt aaaccgtttt ttaatcgtta acgttaaaaa gaataggtta 2565361 atcgtcatat cgctcacccc ctttcaaagt ccgcatcaag cgaaataacc cgcggcacaa 2565421 cccttctgcc gcgggcaaat aaaaaccgca gacaaaagaa gacaccaatg cctctactgc 2565481 ctgcggggag ttgcgtatgt ccgactattc cgaatttaat gcgtgcgata agcatcggtt 2565541 aaggaaggac acgaactctt ccacaggctg aataaaccat gaacttttac atgtgtatca 2565601 cgtacaggtt gacgtcgttg tctcattgtc attttggttc agcctccttt gcttttttct 2565661 tactttgtaa gtatatccac caaattccat tttgtaaaca tctttttcta aaaatggacg 2565721 gaaattgtgc aaatcatcga atggatttgc ccgttggtca tgacacctgc ttcatttctt 2565781 ttctggagcg gtctttctta tgatatgcaa taaaataaat gagaccgaca aatacagctc 2565841 cgccgatgac attaccgata aaagccggaa tgatgtttcc gatgaactgc ccccacgtga 2565901 atgagcctgc aaaaatggca gcaggaatca caaacatgtt ggcgacaacg tgctgaaatc 2565961 cgatagccac aaaagccatg attgggaacc agatgccaag gatttttcct gctgcgtctt 2566021 gggcgccgaa agaaagccac actgcaagac atacaagcca gttacagccg atggcggaaa 2566081 tgagaacctt gccaaagctc atatcaagct ttccttgggc aacggcaatc gttttttcta 2566141 aataaggacc tgtttcagtc aatccaacca aatgcccgaa aaagtaagca acaaacaatg 2566201 cgccgattaa gttcataatt gtgacgattc cccagttaat cgctaactct tttactgata 2566261 tttttctcga aaataacgcc atcgcaactg acatcatatt gcctgtgatc agttcagcgc 2566321 cagcgagaac gacaaggatc aggccgactg gaaatactgc tgcaccaatc aaactggaca 2566381 ggctccccca ttctttcgga agatcgccaa ttaccctgat atcaagcaaa tacccaagcg 2566441 cgataaatgc accgcctaaa aaccccagca caagcagtga cggcagcggg agctttattt 2566501 ttttcatccc tgcttcaatt gctgcttccg ctatttcatc cggttttcga aaagccataa 2566561 taaaacgcct ccattacttc ttcttttctc acagttatgc aagaaaggca ataaaaaagg 2566621 cagcactcaa ataacctgtg tcaaaccagg cgtttgaatg ctgcctaact tgtatgcata 2566681 cccatacaac aatatcaagc agtatataag atattgaaag agaatatata cagttcgtgc 2566741 atacattcca ttgctttagc cttctataac tgtagcaaca tcatatcaaa tgtgacaaat 2566801 ttgtgtcaat gacaaatata ctagctttgc agagcttctt tttgctcatc tatttttcgg 2566861 tcaaaaacaa atacagatac agcgatgttt tcctcaattt taatatcaga aaacaaatgg 2566921 actagcttag ctcccataag ttcctccatt ccttccggtg tttgtttgga ataaaggtct 2566981 tgaattaggc ttgtccgggc cgcatgtacc atctctcttc cttcaggcgt gcgggcaata 2567041 aactgctcgc ttgcactcag atttccgtat agtgttgaaa ctgccatgtt ttctacaaat 2567101 acagtatgaa ttctctcagg cccttttccg aacaattctt tgcgaagttt tcgaataata 2567161 tcattgaatt catgaatttt tttagacatg ctgattaccc cttccgatat tgccttataa 2567221 aggcttttcc cggttcccct caggacattt cacttggtta aaattttcct gccatattgt 2567281 attataataa atatcacatt ataataaaag cagtgttgat ggatttgtaa taggatcttg 2567341 ttatgagtct atcgttttat aaaaatcaag gattggtctg ttagtaagac ttgctagtga 2567401 actattccgc catgtgtgtt tacaccttct tagaattaag ggcaggtgta tctatacatg 2567461 gctttttttg acttcttgaa agaaagatgg aggggaatat gaatatgatg gacgttaagt 2567521 cgatcagtgt ccgtgtagac ggaacagaaa ttcaagcacg agcaggggcc acaattttag 2567581 atattttaaa tgaaaacgga attgagtacc cgcagatttg ccacgtacca gaggttgacc 2567641 cgattcaaac ttgtgatact tgcatagtag aggcaaacgg caagctggtt cgttcatgcg 2567701 cgacggttgc agaaaacggg atgtctattg atctttcagg aaatcgagtg aaagaagcgc 2567761 aaaccgaagc gatggaccgc cttcttgaaa atcatttgct gtattgtaca gtttgcgata 2567821 acaacaatgg aaactgtacg ctgcataata cagcggaaat gatggggatc gagcatcaaa 2567881 aatacccata cacgccaaaa gaagatcctt cttgcgcggt tgatatgtct catccttttt 2567941 accgctatga tccaaaccaa tgtattgcct gcggccagtg tgttgaggtc tgtcaaaacc 2568001 ttcaggtaaa tgaaacactc tcaatcgact gggaacgcga acgccctcgc gtcatttggg 2568061 atgagggagt tccgatcaat gaatcttcct gtgtcagctg cggtcagtgt gtaacagtat 2568121 gtccatgtaa tgcactgatg gaaaaatcaa tgctcgggca ggctggtttt atgacaggca 2568181 ttaaagagga cgtcatggaa ccgatgattg atctcgtgaa aaatgttgaa ccggggtatg 2568241 gcagcatttt tgccatttct gaagtcgaag cggcaatgcg tgaaacgaga acgaaaaaaa 2568301 cgaaaactgt atgtacgttc tgcggtgtcg gatgttcatt tgaagtatgg acaaaaggac 2568361 gggatatttt aaagatccag cctgtttctg atgctccggt taacgcaatt tccacatgtg 2568421 tcaaagggaa attcggctgg gattttgtca attcaaaaga gcggatcaca aagcctttaa 2568481 tccgtaaaaa cggagccttt gtggaatctt cttgggaaga agccctcgat cttgtcgcaa 2568541 gcagattagg atcaattaaa gagcagtacg gtaaaggctc tgtagggttt atttcttctt 2568601 ctaaaattac gaatgaagaa aactacgtca ttcaaaaact agcgcgtcag gtatttgaaa 2568661 caaacaacgt cgataactgc tcacgctact gccagtctcc tgctacagac ggattgttcc 2568721 gcactgtcgg catgggcggt gacgccggca cgattaaaga tattgccaaa gcaggcctgg 2568781 tcatcattgt cggtgccaat ccggcggaag gacacccagt gctcgcaaca cgcgtcaaac 2568841 gggcacacaa gctccacggt caaaaactga ttgttgctga cctgcgtaaa aatgagatgg 2568901 ctgagcgatc tgatctgttc atcagcccta aacaaggcac agaccaagtt tggctgatgg 2568961 ctgttacgaa atatatgatc gaccaaggct ggcacgatca ggcgtttatt gatgagaacg 2569021 tcaattactt tgaagattat aaagaaaccc ttaaaacgta tacgcttgat tatgcagaac 2569081 gcatcacagg cctttcaaaa gaaaacatca ttcaaattgc tgaaatgatt cgtgatgctg 2569141 acggcacttg tgtcctttgg ggaatgggtg tcacacaaaa tacaggcggt tctgatacat 2569201 cagcagccat ttcaaacctg cttctcgcta cgggcaacta tcgccgtcca ggtgccggcg 2569261 cttatcctct gcgcggacac aataacgtgc aaggcgcatg tgatatggga acattgcctg 2569321 gctggctgcc gggatatcag catattacag atgacaaagc acgcgctaaa tttgaagagg 2569381 catatggtgt cgagattgat ggaaagcctg gtttagataa tattcaaatg cttcatgcca 2569441 ttgaagaagg aaaaatgaaa gctatgtatc ttgtcggtga ggatatggca ctggtcgatt 2569501 caaacgcgaa ccatgtgcat gatattttat caagccttga tttcttcgtg gtacaggaca 2569561 tcttcctgtc aagaacagct caatatgctg atgtcgtctt gccggccact ccttcacttg 2569621 aaaaagacgg aacatttacc aacacagaac gccgtgtcca gcgattgtat caggcgcttc 2569681 cgacgcttgg tgacgcaaaa ccggactggt ggattattca agaggtggca aaccgtttag 2569741 gagcgaattg gaattacagc catccaagtg acattttctc tgaaatggcg agtctttctc 2569801 ctctgtttgc caaagcaagc tatgaggtgc ttgaaggctg gaacagcttc ctatggggca 2569861 gcttcacagg tgaaagcaca ccgcttctgt atgaagacgg atttaatttc cctgacaaaa 2569921 aagcccgctt tgccctttct gattggaccg agccagcggc atttccggag gaatatgacc 2569981 ttcatatcaa taacggccgg atgctggagc atttccacga aggaaacatg acaaataaat 2570041 cgaaaggcat ccaagcgaaa gtgccgaatg tattcgttga gatctcacct gagcttgcac 2570101 aagagcgagg tgtttgtgac ggttcgcttg tacggctcgt ttctccgttc ggagcagtca 2570161 aattgaacgc gctgatcaca gaccgggtac ggaaaaatga actctatttg ccaatgaact 2570221 cgacagacaa ggagtcagcg attaacttct tgacgggccc tgcagctgat aaacggacga 2570281 acacgcctgc ttataaacag acaaaggtcc gcatggaagt gcttggcggc tgtgaaacag 2570341 cgccgcttcc aaaaacaaat ccgcgcaaca aaaaacggca tccgcaaaac ggagtcgaag 2570401 cagaaagaaa atggaaccgc cctggctatg tacatctgac tgattaaacg ataggaggaa 2570461 aacgaatggc cactccgatt acgacgatca aaaaagaaac aaaaacagct gagcaaatta 2570521 agcttgaaaa aatagaagaa ctgaaagagc tgctggcgga aaatgaggac gccgtctcta 2570581 aaacgatgac gttaatgaat gaactcaatg atcttggaat ttttgatgcg gcaacaagca 2570641 tgctcagagc gaaggaagac attgccaaga ttgcgcttgg ccaagtttcc cgcgagcctg 2570701 tcaccaacct catcaacacg atgatggccg ccggaggcgc attgacaaaa gccgatcctg 2570761 agtttacagc aaagctttta gaaagcgtaa tggctgggac tgaacaggca caaagctttt 2570821 taaaagaaga caagaaagtc gggattctcg acctgttaaa agcaatgaac gatcctgaca 2570881 tcaacagagc cgtcgggttc ggccttcagt ttttaaaagg catgggaaaa gaacttcgag 2570941 aacaataaca gaaaaacagc catctctgat gatggctgtt tttttattcg tcggcttctt 2571001 ccagacgctt cttgtaaata agtgaacggt cagcgcaaaa gaaggcaccg gctaaaaata 2571061 cgcaatccgc taaaaacatc gtcgatttct ggcctaatgt taagccttga tcagggagaa 2571121 ctgcgcctat atataaaaaa gtgctgactg caagcaatgt aaaagcaaaa tgcttgtagt 2571181 cttcttttaa agatttcatt ctatttttgt tcaaaagaat cacctgccag attcatagta 2571241 tacgactatt ataatataat ccggcggctt acagagaaag taattctatc catttgttat 2571301 atattttcaa gcgcttggcc gatatcttcc aacaagtctt ccgcatcttc aattcctaca 2571361 gaaattctga tcaagccgtc cgtaatgccg agctcaagcc ggcgttctct cggaatagag 2571421 gcatgtgtca ttcttgcagg aacagaaatt aagctttcaa ccgcccccag gctttcagca 2571481 atggtaaaca gtttcagatt tcctaaaaac gcatcaaccc gttcttcact gccaatatca 2571541 aaggagatca tgccgccgaa gcccgctcct tgcgtttttg caagctcatg tccgggatga 2571601 tttgaagaac cagggtaata taacgtttgg acagcagggt gattctcaag aaagcttgcg 2571661 attttccgcg cattttgatc gatcgcttcc attctgagtc ccaacgtttt gattcctctc 2571721 attaacagcc aggaatcttg agggccgagc acgccgcctg tggagttttg cacaaaatgc 2571781 agctcttctc caagctcttt cgaagctgtc acaactaaac ctccgacgac atcactgtgt 2571841 ccgccaagat attttgtcgc actgtgcagt acgatatcag cgcctaaagt aagcggctgt 2571901 tgaaaataag gagtattaaa ggtattgtct acgataagca gaacacccgc tttttttgcg 2571961 atatcagcca tgagcgtcag gtcggtgatt ttgagcaacg ggtttgtcgg tgtttcaata 2572021 taaattgctt ttgtattagg gcgaatcgct ttttcaactt cttccctgct gctcgtatca 2572081 acaaatgttg attcaatgcc aagacggtta agcacctttg tcatcacgcg atatgttccg 2572141 ccgtacacat catcagtcaa cacgacatga tctccgctgt taaacagcat cataaccgct 2572201 gtaatggcag ccattcctga gctgaacgca tagcctgctt ccccgctttc cagttctgtc 2572261 acaagtgctt cgagagcggt tcgagtcgga ttggccgttc ttgaatactc gtagcctgta 2572321 tgctgccctg ctttcggctg cttgtacgtg cttacttgat aaatcggcac ggaaactgcg 2572381 cctgttttct catcacctgt gattccgcca tgtatcatca atgttttttt cttcatatca 2572441 gatgcctcct tcgtatattt gtttgctgat atatcgatcg ctgctgtcag gaaatactgt 2572501 gacaatgtta gttccagcgg atgctttttt cgcttcctcc aatgccgcat aaagcgctgc 2572561 acctgaagag cttccgatca gcaggccttc tttttctgcc gcttctttca caagtctaaa 2572621 cgcattctca tctgttacgg tgtagatctc gtcaaaatgg ctcttatcca tataatcggg 2572681 gataaactcc atgccgatgc cctctgtttt atgagcgtgg ggctctcctc cgtttaaaat 2572741 cgagcccacc ggttcaacaa tcaccgtttt gactgctgga tttttttctt ttaagaagga 2572801 agctgtccct gcgaatgtgc ctcctgatcc tgcccctgcg acaaatgtat gaatattccc 2572861 gtcaagcgct tcccacattt caggtccaag cgtcttatag taagtcgatg gatttactcg 2572921 gtttttaaat tgcaaaacgc aataagaatt ttcaatttca gtctccagct gaatggcttt 2572981 ttgaatggct ccctgcattc cgtcttgacg cggtgtatga atgattgatg cgccaagcgc 2573041 ttgcataatt tgctgtttct ctctgctgaa atgttcaggg acacagaaaa tcgctttcag 2573101 cccatatttt ctggcactta acgcaaggcc gatccctgta ttgcctgccg tagcttctat 2573161 aatcactccg ccgggtttca ctttgcctga atcgagcgcg tcacgaatca gcatatctcc 2573221 cagtctgtct ttgatgcttc cccctggatt catcatttca agcttggcat acaccgcgac 2573281 tccttctgga acatcaaagt tcttcaagcg gagaagcggt gtattcccaa tcagctcggt 2573341 aatgtccgta atcactgtca tatatgtcct cctccttaat agaggttgtt tttagagaaa 2573401 aacggaggag aacgttctcc ccgttttaat gaattcgttt gatcaccttt aacacaagct 2573461 ctgttgaatg aacagccgcc tgctctaaaa attggtcaaa tgaaacatgt gattctttgc 2573521 ctgcgatatc tgataacgct ctgatgacga caaacggcgt tttaaattga tggcatactt 2573581 gagccactgc cgcagcctcc atttcaaccg cgtacagatc agaaaatctc gcacgcacct 2573641 cttcaacccg cttcggatcg ttcatgaaag aatcgcctgt tgcaatcgtt ccttttgcaa 2573701 cctgaatgcc gtcgagttca gataccgctt cttcagtgat gctgatcagc ttttcatccg 2573761 ccgcataagc agccggaaga cccggcactt ggccgtattc atagtcaaaa gccgttacgt 2573821 ctacatcatg gtggcgaacg tcagtggaaa tgacgacatc ccctacattc aatgtatgat 2573881 gaaatccgcc ggctgagcct gtgttaatga cataatcagg cttgtaacgg tcaagcagaa 2573941 gcgtcgtgct gatagcagca tttacttttc caattcctga ttttaaaaga atcacttcag 2574001 ttccttcata ttcgcctgtt gtaaattcac agtgtgcgat cgtttctgtt tttgcatttt 2574061 caagtttgtt tcttaagatg gtaacttcct cttccattgc tccgatgact gctagtctca 2574121 tctattcaca ttcccttcac tttaccgttt gatcgcctcc attatccaca cgaagtcgtt 2574181 ttgctgagtg aatcggactg caaaaccttc agctgtaaac atttctttca acgcatccaa 2574241 tgtaggataa tgctctgtct ctaaatcatt tgcaagctga taaaagcctt gagaacgggc 2574301 tttatcgata gcctgttgat acgcttgcgc attttcaaag acggtatcgg caaacactat 2574361 tttatcatgc aagtgaaggt atttgccata ttgctttatg gcagcccgct tttcttcgtc 2574421 agtcaaatga tgaaaagcat atgaactgac aatcgtatca gcctgaaatg gcggctcagg 2574481 gaatgtcagg aagtctccat caacgatttc cgtcctgcct gagagcttgt cagaagccag 2574541 tttacgcatt gctggagaag gttcgattcc aaatacagtt ttgcctgcat cgagcagctt 2574601 agctgtcaaa ttcccggtcc ccgggccaaa ttctaacaca tgcgttccag attttctgac 2574661 gatggcatca aggatatgat cgtagcctct gaacgcttct ttatactgaa tatctaaacc 2574721 ttgtactgtt tgatcataag ttgctgccca atcttcaaag agagggataa attcacggcc 2574781 catatttgtc acactccata tttaataatt cctataagta tactatggat taatgatgga 2574841 acagttccta taataccaca tattctgaaa agcaggtact aaaacacttt gtgtatttta 2574901 tgccatctca tattgcgcat tgaccgcaaa aaagcttata cttcatatga cttgtgaaag 2574961 ctggagggtc aagacatgaa ttttcaatta gatctgatta aagacaaagt ggaatttttt 2575021 gaagcggctt cattgcagga gcttgaaaag aaaatcaata cacaaattga aaacaataaa 2575081 gccatcatgc tccgggtgaa atctgtttca caccaaactc ttgtggcaga aggaagaata 2575141 ttgtacagcg cggtggttca tttctcagct gaagcctaaa acaaaagcag ccggttttaa 2575201 cccggctgct tttgtttatt ttagcttttc tacttttgtc ggcttccagc ctttttcatc 2575261 gacccatgta atcgtgactt gatatttatt cccagtcgcc ttgtccaaaa tcttgccttt 2575321 ggcatcctga gggctgccgt tatttccaag ccagagcacc gtcatgttat ctgttgagac 2575381 accagttgcg tacgaaatgg ctttcagcat ctcagcccag tcttgtgagc ttgaatcata 2575441 agtagcggca tgctcgccag tctgctcagt tccgactgct ttccagtcag gattttcata 2575501 cgttttttcc acatcgctcg atgagccgcc ttctgttact tttgcatctt taagcccgtc 2575561 accggctgaa tctgagcttg aatctgaatc agagtcatct tttttagaag aagaatcatc 2575621 ttttttggaa tcagagtcag aagacttctc agaatccttt tcgctgtcag atgtatcttt 2575681 cttgctgtct tttatatcct catccgattt cttttccgtc tttcctgaag ccggagattc 2575741 ctgtttttgc gccgtttcag aatccttgct gacatctttg ctagaaggac tgttaatgaa 2575801 gagattcgct gctactacga caattagtat ggatacgatt gcgattaaaa tgttaagcac 2575861 taaattggct tttctgcgtt tatcacgatt ttcataacga gattgattat tgctcaataa 2575921 ttctgcactc ctttatccct cttggctcag catatatttt aacatgtgct gagaagttgt 2575981 tctatttctg attgatttca atttcgtgta cttttttaac aatatcataa aacaccgaat 2576041 ttgtcagagc cttatctccc ggtgtatcca tgtgtaaaac aactagagcg tatttcggct 2576101 tatccgcggg aaaatatccg gcaaaccatt tttcgtagag cgtttccttc tcttttgaaa 2576161 gcttgcctgt ctgggctgtg cccgacttcc ctgctacagt atacggaaga tcttgaaacc 2576221 ttctgcccgt tccggaagga gattctacta cccgccgcag tattttttga agctgctgtg 2576281 acgtatattt gtctatcgtt tcccctttga gcttctgatc tttaaacgta acgagcgttg 2576341 tgccgttctt atactcaatt tgttcggcaa ttttcacctg ccgtttttct ccgccgcggg 2576401 cgattgtcgc catcatattg gctacctcca gcggcgttac ctttacattt ttctgcccga 2576461 ttgctgtttg cgcaatggct tttttgactg atttgtcttt ttcatccccc caaatcacgc 2576521 cgcttttttc gttatacagc tggcggaaat cggtttcgtg gtacagtttt ccctcccagc 2576581 ctgcccgatc agtgagagcc agcttctcgg acatatcttc aataaccgag ctgtcttttt 2576641 tcattaattg ttctgcaaga ctcgtaaatg tgtaattaca gctttgggca aaactttcat 2576701 caaaagacaa ggtgcctttg tcgtcccccg gttccccgta caggtttaaa ttgcaattaa 2576761 aggtttgact aggcttcacc atattatttt cgattgcagc tgcggcaatg actgttttaa 2576821 aaactgatcc gggatagatt ggcgtcagca tataattttg aagtgtgttt tgccgggaca 2576881 cgtctgcatc tggtttgctt acaattccca gaacactgct attttcgatg tccagcagca 2576941 cagctcctcc ctttttcagc ccctgttcat ccaatacctc ctccatcgct ttttgaatgc 2577001 tttgatcgat cgttgttttg atctggagcg gataaaatgt attggcttca gctgtatatt 2577061 tgacgtccat gccaaacaaa gggtttcctt ttccgtccac atgatataaa agctttgtgt 2577121 cttgttccgg aagcaaaaac tcgtcaaatg tccgttctaa accggttgtt ccgatttctg 2577181 ttgtaatcgg aaggctctcc ttgtcaggat atttcttgcg aagcagcgcc ggatcttggt 2577241 tcgtgctccc tatcgtatgt gaagcaaggc tgggcttgtc ttcattctcc atatatacgc 2577301 cgtaaatgcc gggatatttc aaagaattga tttttgtgat agattgtttt gaaagtgttt 2577361 tgattttctt ttgctgcaaa atgaccggtt tttttgcctg acctagtgtc tggcgcaaat 2577421 catcttcaga catgccgagg atgtccgcaa cttttttgat cggccaatcc tgcgtcagca 2577481 gaaaagggaa caaaacaacc gcaggctcgc tttgtcctgt cagcgcccgc ccgtttcgat 2577541 ctaaaaaaga gcctcttcca tctgaaatga gcacttcctc cgtccgctgt ttcacacttt 2577601 cttgaatcaa attaattttc tttttagaaa atgattctgt gaaaaacagc tggatttctg 2577661 caagtctcag cagaagcaga aaaaatacaa tcaaaaaagc gatgactgcc agcttcattc 2577721 gtttcgatat cttcataaaa aaacacctca cccacattgt ggacgaggtg tttcgctgct 2577781 aaacagatat tatgaaattt tcacaatttt cacgagcatt tctccgcccg gtgtttgtac 2577841 tgtgacttct tcatctactt ttttgcccaa gaggcttttt gcgatcggtg aatcgtttga 2577901 gattttccct tcaaacgggt cagcttccgc gcttccgacg atcgtatatg attcttcatc 2577961 accgtcaggc agttcgacga aagtgacggt tttacccaaa ccgacaacgt tagagccgcc 2578021 gtcatcttca atgattttcg cattgcgaat catattttca agagtcgtca cgcggccctc 2578081 tacaaatgcc tgctcttctt tcgctgaatc gtattcagag ttctcggaaa ggtctccgaa 2578141 gcttctcgca attttgattc gctctactac ttcttttcgt ttaaccgttt tcaaatattc 2578201 taattcttgt tcaagttttt gttttccttc tgcagtcata ggaaaaactt tctcttgtgc 2578261 catgtccctt cactccttct ggttgtccct caacatcttc gattatgtat gagagcataa 2578321 actaaaaaat acaagaatga gaacacaggg cagtcctcgt tcttctctcc catataggta 2578381 ctgtttatct taaactgaat cgtgtcgttc tgcaaatatt tcgcgtttat aaacagggaa 2578441 agaagggaat tcgcacattc ccttcctgcc tatacataat atggtcagag ttatttatgt 2578501 ctatgctatg gtattacaaa atcgcgtttt gttcaagaat ggtttgaatt tttgtgacca 2578561 tcagatcaat tgcgacgtga ttctgaccgc cttccgggat aataatatca gcgtatcgtt 2578621 tcgtcggctc gacgaattgg ttatgcatcg gacggaccac tgacacatat tgttcaatga 2578681 cagaatcaat agagcgtccg cgctcattaa tatctctcat aatccgtctg atgatacgca 2578741 agtcagcgtc cgtatcaaca taaagcttga tatccatcag atcacgaagc cttttgtctt 2578801 caagaacaag aatgccttca aggataataa catcctttgg ctctacgtga accgtttctt 2578861 ctgaacgtgt gtgaagctta tagtcataaa tcggcttttc aatcgggcgg taattcaata 2578921 gatcttgaat atgctcgatt aaatagtcat tatcaaacgc aagcggatga tcatagtttg 2578981 tgttcagcct ttcttcaaac ggaagatggc tttggtcttt ataataaagg tcctgctgga 2579041 tcattaaaat tgagtgtcct ttaaactgtt cataaatgga ccgtgtgaca ctcgtttttc 2579101 ctgaaccgga acctcctgcg attccaatga ctactggatt cttacccatg ggctgttact 2579161 tcccctttct catcatgttg ctcggataaa tctttttgtc tagtttgaat ttgacaattt 2579221 gcaggggatg gcgggcagca tctagctcat ttccgtcttc gtcccaaatg gtttcaatcg 2579281 tatgtgtaaa gttttcgatt tctggaccga aaaattccac ttcgtcgcct tttttgaaga 2579341 aattgcgctg ctgaagcgtg accatttgtg tatcttcatc ataattcagc actaagccga 2579401 caaaatcata tgtcgttttc ttggcgtgtt cgccgaacat ttgctcttca tagcctggcg 2579461 ttccttcaaa gaaagctgtc gcagtgtccc tgttggcgca cttatcaagc tcttcaagcc 2579521 attctttttg aatcacaaag ttttctggat cagcgcaata agcatcgatt actttgcggt 2579581 atacgctgac aacagttgct acatagtgaa tggatttcat gcggccttca atctttaagc 2579641 tgtcgatccc catttcaatc atttttggaa tggattcaat cagcttcaaa tctttcgggc 2579701 tcatcgcaaa tggtgcatct tcttcaccat acaaagcaac ggcgttggca ccgtctgttt 2579761 ggtagagatc ataatcccag cggcatgact ggcagcagcc tccgcggttg gaatcccgcg 2579821 ctgtcatgtg attgctcagc acgcagcggc cggaatatgc aatacacatt gcgccatgaa 2579881 tgaaggattc gatttcgata tctacctttt ctttcatttc tctgatttca agagcgctag 2579941 tttcacgtgc cagcacgacg cggtcgagac cttcttcctt ccagaactgg acagccttcc 2580001 agtttgaaag agactgctgt gtgctcaagt gaacctcaac attcggcgcc actctgcggc 2580061 atgtttcaat aataagcgga tctgccacaa taataccggc aacgttggcg tctccaagcg 2580121 cttttaaata gtcttcaagc ccgtccatgt tttcattatg agcgaaaata ttcgttgtta 2580181 cgtagatctt cgcgccatat ttctttgcga attcaacgcc ttctgcaatt tcttcgatcg 2580241 taaagttatc ggcattcgag cgaagcccgt attcctgtcc cccgataaag accgcgtccg 2580301 ctccgtaatg aacagcgatt ttcagctttt caagattacc cgcaggtgcg agaagctccg 2580361 gctttttcgt aatcacacgc tttccattaa cgattgtgga tattttatca tttacggcag 2580421 tcatagctta acctcctttt gattaataaa ccgtttcctt gaagaagaat ccggtatcaa 2580481 tttttctgtt tactggctgg atgctttcaa tgcgttcgat ccagtcttct tttttcgctt 2580541 cgtattcgtc acggttttcc acgcacaaat caattgcttc tctgtacatt ttggtgactt 2580601 ctattaggta ttcaggcatt ttcaaaacac catcgatttt gaaagaatca attccggcat 2580661 ctatcaattc ctcgagctca tcaatgatgc acacatcgtt cgggctcatg atgtgagtgc 2580721 cgttttcatc ttcgaaaatc ggatatttat tatcgcgttc tttatcgtgt aaaaacatgc 2580781 ctgattcttt tttctttctt tcaatgtcca tgactttgcc ctgatattca aaatagtttc 2580841 caatcaaaga acgcttcgat tggaacatgc acgtcattcc atgcacctgg atttcaattt 2580901 cgacttcagc attttcttta atctcaacaa tgctgtccat gtttaattct ctggcaagca 2580961 cagaacgcgc cgcacccttg cgtccccagt agttgcatgt ataatagttg gtgcctgtcg 2581021 tttctgtgct ccaatgaagc ttcagatcag gcgcagattc acgggcagcc atcagcacgg 2581081 caggatcgcc gaataccgct gcatcgacac cggcttctgc taagaaagcc agatattcgc 2581141 caagctcacc cactttatca ttatggaaaa ttgcatttac agcaacgtat acttttgccc 2581201 cttctttgtg agcaatctct acggcttttg ttacatcttc acgagaaaat tctccggcta 2581261 atctcaagcc gtatctctgt tccccaacta aaaacgcagt tgccccagcc tgtatgagcg 2581321 gcaaaatgtc cgctgtactc gtcggcgtca ctaagagctc tggttttttc atgacgttca 2581381 cctcttcttt ttactaatcg caagtccgtc cccgacagga ataatcgcag tttgataatc 2581441 cggatgattc atcagccaat gattatattc atcaattttg gctacaagcc tgcgccttct 2581501 cttcggttct attttgctgt aatcctctgc caccagacct ttaaacagca cgttgtctgt 2581561 tataatcacc ccgtccggtg aaagcatcgg ttcatataaa tgaaaaaagt tttgatactg 2581621 accttttgca gcgtcaataa aaatgacatc gtaaggcgcg gttacatgaa cggcgtcggc 2581681 taattcaagc gcatctccgt aaaaaacatg aatccggtca tcaagctgaa attccttgat 2581741 attgtttacc gcttcttcat gccgtttctc attgcgttca attgtatata tttcagcaga 2581801 cggcagttcc agagccattc gaatggctga ataaccaatg gccgttccga tttctagtat 2581861 ttttttcggc tgtttcacag acaaaatttg aagcagcacc tccatgcccg ctttttccat 2581921 aatcgggaca tgatgttctt ctgcatatgc ttcaagtctc ttcacgttat ccggccgagg 2581981 ctttaataat gcttctatat agtcatttat ttgttcatac cggtcagtca ctacaaacag 2582041 cctcccgttc taaaaaggag tgccccagtc ttatgcgcag gacactctct gaatacatca 2582101 tgatacatcg gtaaacaacc cgatatattt tatcataaaa ccttgcggaa agcgaacaaa 2582161 aggagagctt tttgctctcc ttttatttct cattttttga ggaaatgtat ttttcttttg 2582221 ctttattatg ctcttttagc gtttttgtaa atacgacctc accatttgat ttggccaaga 2582281 aatacagata gtccgtttta tccggatgca gcgctgcttc ccatgatgac atgccggcat 2582341 tggcaatcgg ccctggcgtc agccctgtgt ttttatacgt attgtatggt gaatcgattt 2582401 ccagatcctt ataaagaacc cgatctttat gcttgcctgc cgcgtacagg acggtcggat 2582461 ctgtttggag cggcattttc tttttcaggc ggttataaaa gacgctcgca attttatggc 2582521 ggtcggcttt ttcagtcgct tcttcttcta tcaaagaagc cattgtcagc agcttatgca 2582581 cagaaacttt gtttttcttc atttctgatt tatatgtttc cacataagaa tttgtctgct 2582641 taatcattgc cttgataatg tcttcaagtg atgtgtccgg atcgttaaaa gggtatgtag 2582701 ccgggaatag gtacccttca agcgggtgct taatgttttt attgaaaaca tcatttgtca 2582761 cagtgtccgg gaattctttc ttcagctgat tgataaatgt ttcatcgtcc agcttcgcta 2582821 tgacttgttt tttagagtat tttgtttcat cagcaatagc agccgcgatt tgggtcagct 2582881 gtgctccctc agtcactgtg atttgaaaag cgtaacctgt agccccgctt gtcagcttct 2582941 gaataatggc atctaaatcc atacctttat tcagatggta gaatccggcc tgaaacccgg 2583001 aagcaccttt atatttcaca tagtactgaa acgccttctc gctttttatg acatcatttt 2583061 tctttaatat cgatgcgatg gctgaaacag acgaaccgct cggaatgtta atattaactg 2583121 tcgttttact gtctttttca acaggttcaa gcaatgattt cccatataaa aatgccccgc 2583181 caatgatgag aaacagcaca acaatggaag acagtatgat tcttttttta ttaaaaaacg 2583241 attttttttg ctgattgata tacattaggt ctcctcccat cagctcttat actacatgat 2583301 tcattgtatt tcggcaattt attacaaaaa gaggcctgca taaagcagaa aaaagccgga 2583361 gcagtatagc tccggctttg gtttggcgcg atgttttact cttcgtcttc gtccgctaag 2583421 aatgtgttta gtgtttcttc gatcatatcc cattcttcgt cagtttcaat cgggaatagc 2583481 tcaccgtttt caccgtcttc gtttggcgtg aagctggaag caagaatttc tacttcttcg 2583541 tcatcttttg attcgattgg atagtacaag acataagatt tgccaaactc ttcattttca 2583601 aatgtaaaca gcacttcaca aagctgttca tttccttgat cgtcaacaat tgtaatattt 2583661 ttttcgccgt gttccatttt cttcacctct ggctttaatt taagctgtca agatatcctt 2583721 gtaaaatcat aacagccgcc attttatcaa tgactttttt tcgtttttgc ctgctgacgt 2583781 cagctgcaat cagcattttt tcagccgcca ttgtggtaag acgctcgtcc cacagcacaa 2583841 caggaacatt gtacgttgtt tcaagcactt tcgcaaatgt ttggctggct tcgcctctcg 2583901 ggccgactgt tccgttcatg ttcttaggaa agccgagcac gattttatct atagtatagt 2583961 cctttatcag ttcagataaa cgggataaac cataatcgcc ttctgcttca tttatcttta 2584021 tggtctcaat gccttgagca gtccagccca tttcatcgct cagagctaca ccgagtgttt 2584081 tggttcctaa atcgagtcct aatattctca ttctttattt acgcctcttt atgctgttct 2584141 aaataagact ttaccaattc ctcgattaat tcgtctcttt caagtttgcg aattaaattg 2584201 cgagcgtcac gatgcctagg aatataagcg ggatcacctg acagcaagta tccgacaatc 2584261 tggttgattg gattgtagcc cttttcctga agcgcgtcat acactgtaat cagcacctca 2584321 tttacgttag tctcagcaga atcatcggag aaattaaatt tcatcgtttt atcaaacgag 2584381 ctcaccgttt tgcacctctt tcccaaattc gcaggcaaag ttcagcctgg ggtcctaatc 2584441 ttaccatcat tctacactac atgggcgaat tataaaacgg atttcaccca atcttctaca 2584501 gaagccaaag cttcttctaa tttttccggc tgtttaccgc ctgcctgcgc catgtccgga 2584561 cggcctccgc cgcctccgcc gcaaacttcc gcagcttgtt taaccagctt gccggcgtga 2584621 agtcctttct caatgaggtc ctttgtgact ccggcagaga tattaacttt atcgttttgt 2584681 accgcaccaa gcacgatcac cgcagagcca agctttgctt tgagttcatc gaccatagtg 2584741 cggagatgat tcatgtcttt tgcatttact tttgccgcaa gcacgtttac gccgtcaact 2584801 tcttttactt tcgacaggat tgctcctgct tccacgttgc ctagttttgc aagaagagat 2584861 tcattttctc tttgtgcatc cttcagttca gcctgcagag ccgcgacccg tttcggcact 2584921 tctttgatat ttgttttcag ctcgtcagcg gtctgcttca atacagaaat ctggctgttc 2584981 atttcgacgt aagcgccttg tcccgttaca gcttcaatcc gtcttgtgcc tgctccgatt 2585041 ccggattcag aaacgatttt aaacaagccg atttctgctg tatttctgac gtggcagccg 2585101 ccgcacagct ctaagctgta atctccaact tgaacgacac ggacaatatc gccatatttt 2585161 tcgccgaaca gtgccatcgc acccatttct tttgcttcag cgatcggttt caaatcaatg 2585221 ctgaccggga tgctcgccca gatcttttcg tttacgattc tttcaatttg ttcgagctct 2585281 tcttttgtca cttggccaaa gtgcgagaag tcaaaacgaa ggcggttttc cgttacaaga 2585341 gagcccgcct gattgacatg agttccaaga acatctttta gagcctgatg caataaatgc 2585401 gttgccgtgt ggtttttaat gacgccgctt ctcatatggt cttcaacttc agccgtaaca 2585461 tgcaggcctt tttgaacagt accgctctcc acaacacctt catgcacatg ctggccgttc 2585521 ggcgcttttt gaacatcttt aattcttaca actgcctgct cgcttcggag atagcctttg 2585581 tcgccgattt ggccgccgct ttctgcatag aacggtgttt catcaagaat gatttgaacg 2585641 ctttctcctt catgagcctc ttcgattaat tggccgtcct gaagaagcac aatgatattg 2585701 gcatcagctt tggtttgaga gtagccgaca aatgtgcttt caactgtcac gtcgcgcagt 2585761 gcgccgccct gcacctgcat gctgccgaca tcctggcggg cgtttcttgc ccgttcacgc 2585821 tgctggttca tttcctcctc aaagccctca tggtcaaccg tcatgttctc gtcttctgcg 2585881 tattcttcag tcaattcaac cgggaatcca tacgtatcat acagtttaaa cacatcagca 2585941 cctgagataa cgctgctgcc cttgtctttt tcttttttga tcatttctga caggatcgca 2586001 agcccttcat taagggtctc atggaagcgt tcttcctcgg ttttaatgac ttttgcgatg 2586061 aaatccgctt tctctttcac ttcaggatag aaatcagcca tgatttctgc gacaaccggc 2586121 actaaatcaa acatgaacgg acgatggatg ttgatcgttt tggcataacg cacggcacgg 2586181 cgtaataagc gtcttaatac atagccgcgg ccttcatttg acggcagcgc accgtcactg 2586241 acagcaaagg caaccgttct gatatggtca gcaatcactt taaacgcagt gtctttcaca 2586301 ttgtctttgc catatgtttc accagaaatc gattctgttg ctttaatgat cggaacaaac 2586361 aaatcggtgt caaagtttgt cggaacattc tggatgacag acaccattct ttcaagaccc 2586421 atgcctgtat caatattttt ctttggaagc ggtgtgtacg tgccgtcagg gttatggttg 2586481 aactctgaga acacaaggtt ccatacttcc aggtaacggt cgttttcccc gcctgggtaa 2586541 agctccggat cttctggatc attaccgtat gcttcaccgc ggtcgtaaaa gatttccgta 2586601 ttcggtccgc tcggcccttc accgatatcc cagaagttcc cttccagacg gataattctt 2586661 tcttcaggaa taccgatttt tttcgcccaa aactcatatg cctcttcatc ttcaggatga 2586721 accgtaacag agagaagctc tttgtcgaag ccaatccact tgtcgctcgt taaaaactcc 2586781 caagcccatg taatggcttc ttctttgaaa taatcgccga tggaaaagtt tccgagcatt 2586841 tcaaagaaag tgtgatggcg cgcagtttta cctacatttt ctatatcgtt tgttctgatc 2586901 gctttttgag cgtttacgat tcttggattt tccggcacga cacggccgtc aaaatatttt 2586961 ttcagcgtcg caacaccgct gttgatccaa agcagtgaag gatcctcatg aggcactaat 2587021 gacgcgcttg gctctaccgc atgtcctttt tctttaaaga aatccaaaaa catttgacgc 2587081 acttccgcag aagttaagtg tttcattgta tttcctcctc tataaaaatc gaaattctct 2587141 tcagtgacag caaaaaagcc ctccccctat gcaaaccaac gtttacacag ggacgagagc 2587201 tgtctcgcgg taccaccctg attacgggca ttcatgcgcc cgtcaccttt aaccctgtaa 2587261 cgcaggataa gcggcagtga ttaactgcac tcaggattag cttcctccga tcttctgata 2587321 aagctccttt cagcttatgg agcttctctc tttaacaggg cttcggcgta ctcagatccg 2587381 tcactcgaga ttcgtatgta ttctacgaga aattatagac aagcggcacg ccgatgtcaa 2587441 tgctccgtcc tcatccgcaa aaaatggatc atcattactt ttaaaacagc cgtcgcagga 2587501 acagccagaa tcatcccgac gatacccgca agctcccctc cggcaaggag tgcaagcatg 2587561 ataacgaccg gatgcatttt aaggcttctg ccgacaatga acggactgag gatatttcct 2587621 tccataaact gcagaataaa caccgtaatc accacaacaa gaaccgcctt gactgagatc 2587681 gtcatcgcaa ttaacaacgc aggaacagct ccgatgaaag ggccaaaata cgggatgaca 2587741 ttcgttaccc cagagataag gccaagtatc agcggatacg gaagcccaaa tacccagaac 2587801 gaaatgcctg caatcacgcc aagaatcaag cagaccaaaa gctggccgcg gatataatcg 2587861 ccaagcgaat catccacatc ccgcaaaaag gcgctgcccc gctttctcca cgacttcgga 2587921 gtcaagtacc atactgtctt tttcattaac tcaatgtcct tcaccatata aaacacgaga 2587981 aaagggattg ttgcagcaat taagaagtaa tcaagcacat tgcggatccc gctgatcgca 2588041 ccctcgatcg ttcccgcaaa aaacgcctcc gtctggcgga tcattttatc tatacggtga 2588101 tgcataccat caggccagtc atccgtatgg ttatgcacat gaagaagaag cccgttatac 2588161 gtttcggcaa acatgggtat attttctgac aaatccgtca gctgcacgat taaaacaggc 2588221 acccctttat acaacgccca gccaatcccg ccaaaaaaaa gaacataaat gaccaagatg 2588281 ctcaaagtcc taggcaatcc tttgccatgc agccattctg tgaccggaag caataaataa 2588341 gatataaaaa tagaaatgat caagggaata aagatcgttt ttatgacgag ccaaaagggt 2588401 gaccataaca tatcaagcat aaaaaagaca tagactgtta acagaaccag caaacaaata 2588461 gccacccaca acaaaagctg caccggtttt tggagcatct gctttcacct cacctatatc 2588521 ttttgaggtt tacaaggaat tattctttat gtttctttag tcagtcagaa gtcatggaca 2588581 ttttttcact tttaattttc agaaaagttt gatcatttac tttttggtca aattttctga 2588641 taggaggatt gcgatgatca catttcaaaa tgtaaacaag cattacggag attttcacgt 2588701 gttaaaacaa attaatcttc aaatcgaaaa aggtgaagtc gttgttatca tcggcccatc 2588761 cggttccggt aaaagcacat tgctcagatg catcaacaga cttgagtcga tcaatgaggg 2588821 agtgcttaca gtaaacggca ccgccattaa cgacagaaaa actgatatca atcaagtgcg 2588881 gcaaaatatc gggatggtgt ttcagcactt tcatttatat ccgcataaaa cagtgctgca 2588941 gaacatcatg ctggctccgg taaaagtgct tagacaatca cctgaacaag caaaggaaac 2589001 ggcgcggtac tatcttgaaa aagtcggcat cccagacaag gctgacgcct atccttccca 2589061 gctttccggc gggcagcagc agcgtgttgc catcgcaaga ggactggcga tgaagccgga 2589121 ggtcatgctg tttgacgagc cgacatcagc acttgatcct gaaatgatcg gtgaggtgct 2589181 agatgtcatg aaaacactcg ccaaagaagg catgacaatg gttgtcgtga cacacgaaat 2589241 ggggtttgcc aaagaagttg ccgaccggat tgtcttcatt gacgaaggaa aaattttaga 2589301 agaagcagtg ccggctgaat tttacgcgaa cccgaaggaa gaacgggccc gcttattctt 2589361 aagccgtatt ttaaatcatt aaaacagaaa tgggggagct tgtatgaaaa agattttttc 2589421 tttagcattg atttctttat tcgctgtcat cttgcttgcc gcttgcggca gcaagggatc 2589481 aaacggagaa gcctcaaagg agagcaaaaa agatacgcta gccgccatta aagacaatga 2589541 caaaattgtc ttcggcgtaa aaacggacac tcgactgttc ggtcttaaaa atccaagctc 2589601 aggtgagatt gagggttttg atattgatat tgctaaacaa atcgctaaag acattttagg 2589661 tgatgagaaa aaagctcaat ttaaagaggt cacctcaaaa acaaggattc ctatgctgca 2589721 aaacggggat atcgacgcca ttgtcgccac aatgacgatc actgaagaac gaaaaaagga 2589781 agttgacttt tctgatgtct atttcgaggc cgggcaatcg cttctcgtga aaaaaggcag 2589841 caaaatcaag agtgtcgaga atcttggcaa aggctcaaaa gttcttgcag taaaaggctc 2589901 cacctcctct caaaacattc gtgaaaaggc gcctgaagca tctgttttag aatttgaaaa 2589961 ctacgcagaa gcctttacag cccttaaatc ggggcaaggc gatgccctca ccacagataa 2590021 tgcaatttta tatggaatgg ctgatgaaaa taaaaattat caattaacag gaaagccttt 2590081 tacagatgag ccttacggga tcgccgtgaa aaaagggcaa tctgctctcg cgaaagaaat 2590141 caacgcttca cttaaaaaga tgaagtcgga tggcagatac gatgaaattt ataaaaaatg 2590201 gatcaaagaa gacccagctg aataacaacc atcccgggat gagcaggcga tgctcatccc 2590261 aatttgataa ggagtgaata ggcagatgaa tgtgtcaatt cttttcgata acttcagcat 2590321 gtatatggac ggtttttacc ataccttgct cgcaagtgtt atcgcgctgg ccggcagttt 2590381 tgtcctcggc gttgctgtag cggttatgag aataacagtc tttaagccgc tgcaatggct 2590441 cgggaccgca tatgtagaat tcatccgcaa catccctctt cttttaatta cctttgtttt 2590501 ctatttcgga cttccaaacg caggcctgag gcttgacggt tttcaagcgg gaacggttgc 2590561 tctcaccatt tatacctctg cgtttatcgc tgaagccatc agagcaggca tccagtctgt 2590621 ttcaaaaggg cagatggaag cggcacgctc gtcaggcttt acctacagcc aagccatgct 2590681 ccatatcatt ttgccgcagg caatcaaaat cgtcattccg cctttaggca atcaattttt 2590741 aaacttagtc aaaaactctt cgattcttgg ggttgtggcc ggattggatc ttatgtacca 2590801 agccgattta gtttcgtcga gcacactcgt tgtatttgat gtttatattt ttgtggcgct 2590861 tttttactta gtgctgacga ttccgcttag catcggtgtt aactatctgg aaaaacggct 2590921 ggaaaaaagc tattgataag gagtgagtta cattggattt catcggtgct tattcacagg 2590981 agcatttagc gtttttatgg gatggctttc tcgtcacctt gtacgttgct ttcatctcca 2591041 tcattctgag ctttttcttc ggtttaatcg caggcaccct gcgttatgcg aaagttcccg 2591101 ttctttctca attgattgca gttctcgttg aaacgatcag aaacctcccc ttgctgttaa 2591161 ttattttctt tacgtttttt gcccttccgg aaattgggat taagcttgaa attacagctg 2591221 ctgcaattac agcactaacg atttttgaat ccgctatgct atctgaaatt atccgaagcg 2591281 gactgaaatc aattgacaaa ggacaaattg aagcggcgcg ctcctccggg ctgagctata 2591341 cacagaccct gttctttatc gttatgccgc aagcgcttcg ccgcatggtt ccgcccatcg 2591401 taagccagtt tatttcttta ttaaaagata catcgctcgc tgttgtgatc gccctgcctg 2591461 aactgattca caacgcgcaa attattaacg gccaaagcgc tgacggcagt tattttttcc 2591521 cgatcttttt acttgcggcc cttatgtatt tcgcagtcaa ctacagcctt tcactcgcag 2591581 caagacgcct cgaggtccgg caaacataga aaaggatact ctttggagag tatccttttt 2591641 gcattaaaac attttcgtaa ttcttcttct catccgcttc atgcttcgat tattcagcat 2591701 gtcagattga gtcgccattc ggtacacgag agctccggct cccattgcca aaagagaagt 2591761 catcgtccga ttcatcctgc gcatctcctt tcatgattaa aaattgatgc tgcgttcatc 2591821 ctcagaaaac aaatcatcca agctgcttaa cgttccgtct tcttccacct gatgagttgc 2591881 aatcttccct ttcgccactg tcagttcaat aaaacagccc cagcaataat attggttcac 2591941 gccgattttg ccgatatcct tacttttgca attcgggcat ataagcatac ctcacacctc 2592001 tatccgttca gaacgatctc gtctttccgc acctcgacaa gcgaatccgc tctttggatc 2592061 tggcgcttgc ttcccgccag gtcagaaaag aaaccgtccg agagttcata tgctacgatt 2592121 atgcccctgt ccaaacaaaa gtatacatct tccagcatcc ccaatatatc cccctcttgc 2592181 gatttcacaa gcttcatctt catctgctcg tatgtgaagc atgatttcgg aagaggcaaa 2592241 agctgttctg aactgaccga agccaatatg cggtcatcaa aaatggaaga gatatcacac 2592301 gcccgtaata gcgcatgatg atgatgcaaa aagcgttttt gtgcaagaat aaacccaaga 2592361 caatctcctt tcagagaaaa acaaatatcg gaaattgtcc cgagataact agaagttcgt 2592421 tctgagtata ctgggaatcc ttctacttca tggcatgttc tcaaagtgtg atcaaccacc 2592481 ttttgttgaa caggcttagg ttttgctttg cgccttagac tcatacgatg aaatcaattc 2592541 cactgcaaat gaaaaaaaac tcccgcttgc acgggagcat tttattgctg ttcttctttc 2592601 ataaaatcga atggtgtaat gccttccatg ccaatgttgg cgtcgtgtac gctgaacggg 2592661 agctcttttt gcaaagcttc aagctcggca tccatttcct caacctgtac ggacagcctg 2592721 tttttcaagg aggtctgtct gacagttgca tcattatttt tcacgcccca ctccagcgcc 2592781 tcctcttccc cgcataaaat gagaaatttc ttcgctcttg taatcgcggt ataaagaagg 2592841 tttcttctga gcattctata atagcctttc acaacaggca aaaccacaat cggaaattca 2592901 cttccctgcg atttatgaat agaacagcaa tacgcatggg taaattgatt aaaatctttt 2592961 ttcgtaaatg tcatttcatt gccgtcaaaa gaaacgacgg ccatgtcttc tttttctgta 2593021 ttttcctttg cataaaatat cgacgtgatt tcgccaatat ctccgttgaa cacattgttt 2593081 tccggctgat tgacaagctg caaaatttta tctccggttc tgtagacaac atccccgaac 2593141 ttcaattctc tccgtttttc tttaggagga tttaaaatgt cctgcagcat cacattcaat 2593201 tcattaatgc cggcttttcc tctgtacatc ggagcgagga cctgaatgtc ctttgctgta 2593261 tagccttttt tcaatgcatt ggcgacaacc ttctcaacta cttctttgat ttgcgacccg 2593321 ccgcagcgaa taaaggaacg gtcctttgtc ggggcagtca aattgttcgg cagcaatcca 2593381 tttttcatct ggtgggcaag ctcgacgatt gatgaccctt ctgcctggcg atagatgtct 2593441 gtcagtctca cagtcggaat cacctgggat gccagcaggt ctctgagcac ttgtcccgga 2593501 ccgacggaag gcagctggtc ttcgtctccg acaatgatga tttgtatatg atcagggatc 2593561 gccttgaaca aatgattcgc cagccatata tcaagcatac tggcttcatc gataattaac 2593621 agcttccctt cgatcggctg atcctctgta tgagtaaagc cttcagcgcc gttccagcca 2593681 agcagcctgt gtatcgtaac tgcagggagt cccgttgatt cactcatccg ttttgctgct 2593741 ctccctgtcg gagcggccaa aacaatcgga aaagcttcat cctttttata agctgacggg 2593801 tctagtgaca caccgtgaag ctctccgtag agctcgacaa tccctctgat taccgtcgtt 2593861 tttcctgttc ccgggccgcc tgttaaaaga agcatcggcg aggaaagggc tttttgaatc 2593921 gcttccttct ggctgggggc atactgaacg tccatccgtt cttccagttc tcccaacgcg 2593981 agcaaaaact ctgattcggg aaactggttc tcatattcgg tttggctagc gatatgtttc 2594041 acacgctttg caacgttttg ttctgcgtaa aacagcgaag gaaaataaca gcggccatct 2594101 tctatgacaa tgtctttatt ttctccaagg gcaataattg cgttagcggc atccatttct 2594161 gtaatgcgct gcccttccct tgctgactgg tttaacagtg attgagtgtc gatgatcagc 2594221 tgttccgttt ctatgtacgt gtgcccctct gacagacaag tcgtttcaag cgtgtacaaa 2594281 atagcagctt ttacccgctc aggatgatta cccgaaagac ccattctgct gcccagctca 2594341 tccgcttttc caaacccgat gccttctaca tccttcacaa gctgataagg attttcctga 2594401 atcttttcaa gcgtctcgga ttcataggct tgatagattt tcatagacag ctgcgggcca 2594461 aagccaaact gattcaagga aatcatgatt tgctccagtc cctgatgccg ctgcaatgcg 2594521 ccagccagcg tgtctgcttt cttttttgag agtctgggaa catcataaag cactgaagca 2594581 tcagccaata ttttattaat ggcgctgtcg cccagctttt tcacaatttc ttcagctgtt 2594641 tttttgccga tcccctcgaa taaatcactc gataaatatt gaatgatgcc ttccttagtc 2594701 gttggaatct cctttttgaa atgctccgcc tgaaattgga gcccgaattt tggatgggtt 2594761 acgatctttc cgtaaaacgt gtaggtctct tcttcttgaa gcgcagggaa gtagcccgtc 2594821 acggatacgg ctttatcttc aatggcttcg gaggtctctg tgactttcac tttcagaacc 2594881 gtatataaat tggtgtcatt atgatagatg actgtgttga ctgtcccttt taaatagggc 2594941 tcttcctcca gtttaagctg atccggatgc tgctgcacga gctgtccctc ctcctgtgcc 2595001 tgttatgatg gatcaatcag ttttttagca tgaagcgcaa gcatatgatc tggctggata 2595061 tcgattgcct tgtccagcat ttccagcgct ttttctcggt tttctttata agcataagtg 2595121 acaccggcat tataaaatgc atctgcatgc cccgggtctt gctctgtcac agctgcgaat 2595181 tggctgagcg cttcgtccag catgccctcg ttggctaagc acatcccgaa ttgaaaacgc 2595241 gcttccgtat cgttttcatt cagttcgact gctctttgta aatatggcag tgcaagctta 2595301 ggctgttcga gcttgacaag taccgttccg agcatgtaaa acaggtcgcc gttttccatc 2595361 cccgcacgta gcgctttttc aaacatgtct ttcgcttctt tgtacatttc ttttacaaca 2595421 tagacatttc ctgctccata ataagcagtg gctgcgctac tgtctaattc aagcgcttta 2595481 tcataaaacg caagcgcacg ttccagctcg tttacggatg aaagaaggtt ggcaaaattg 2595541 atatacggaa tcgcgtcttc tttattttct tcaatcgctt ttgtaaatgc ctctgccgct 2595601 ttctcgtaat cgccttcctg catcgcctct ataccgagtt gattataatc caccgatcat 2595661 cttcctttca ttaaaaaacc ccaactcagt gttgaggttt ttcatctttt atacgtacca 2595721 caattttgtt ccgtctttgt acacatcatc aattgtcccg ccgccaaggc attcttcgcc 2595781 gtcatagaag acaacggctt gtcccggcgt tacagcgcgg acttgttcat caaagatgac 2595841 ttccgcttca ccttcgccag tcatgcgcac tgttacttta tgatcctctt ggcggtaacg 2595901 gaatttagcc gtgcaggaaa tctcttcgcc cttcatgata tccgaacgta cccagctgat 2595961 atttgttgct gtgattttgt cggaatataa aagcgggtta tggaaccctt gatctacgta 2596021 gaggatgttc ttttcaagat ctttgcctac cgcaaaccac ggctcgccgc ttccgccgat 2596081 gccaaggccg tgacgctgtc cgatcgtata gtacatcaac ccgtcgtggc ggccttttac 2596141 ttcgccgtcc atcgtcatca tatcgcccgg ctgtgcaggg agatattggc tgagaaacgt 2596201 tttgaagttg cgttcgccga taaagcagat gcctgtactg tcttttttcg tcgctgttgc 2596261 aagttctgct tctttggcaa tttcacgcac acggcttttt tgaagttcgc cgatcgggaa 2596321 catgactttg ctcagcgtat cttctgtcag ctgattcagg aagtacgttt gatccttgtt 2596381 ttcatcaatg ccgcgcagca ttctgacttt tccgccgctt ctgtctactc ttgcatagtg 2596441 gccagtcgct aaatagtcgg cgccaagtga caatgcatgc tccaaaaagg ccttgaattt 2596501 aatttctttg ttgcacaata catccgggtt tggtgttctg cctgctttat attcatcaag 2596561 gaagtattga aataccttct cataatattg cttttcaaag tttacggcat aatacggaat 2596621 tccgatttgg ttgcagacgc ggatcacatc ttcataatcc tctgtcgccg tgcaaaaacc 2596681 gttttcgtcc gtatcatccc agtttttcat aaagattccg attacatcat agccctgttc 2596741 ttttaacagc agggccgcca cagatgagtc tactccgccg gacatgccga cgacgactct 2596801 tgtatcctcc ggccgttttt ccatttcatt cactccaatt actacgccgc cttattatgt 2596861 cagccgtttg acaacgtcgg ccacatgttt ggcagcagtt ttcacttgct cagccgtatt 2596921 gccgaggccg aagctgattc gaatagagga cgtcagccgg tcactctctt cgccgaacat 2596981 agcagtcaga acatgtgacg gcaggactga accggccgtg cacgctgaac cgctggagac 2597041 agcgacacca gccatatcaa gattaaccag cagcgcttcc actgacacac cggggaaata 2597101 aagattcaga acatgcggca gactatgctc tttgtccccg ttgacctcga atgccacacc 2597161 tgcatctcta agcgtgtcgg caaagattgc tttaaacgat tgatacttct cgtttttttc 2597221 gtcacgttct tcacttgaca gcttgatcgc ttctttcagc ccgacaatgc ctggaacatt 2597281 ttccgttccg gcacggcgtt ttctttcttg ctctcctccg aataaaaggg gtgaaagctt 2597341 cacatcttta ctagcatata aaaagcctgt cccttttggc ccgttgagct tgtgcccgga 2597401 aacagacaga aggtcaatat ggctgttttt cacatcaatt ggcagcaacc cgaatgcctg 2597461 aacagcatcg gtatgaaaat aagctttgtg ttcctttaac agctcaccga tttcttcgat 2597521 cggctgcact gttccgactt cattatttcc atacatcact gtcacaagga ttgtatcatc 2597581 acgcagtgct tctttcacct gttttgcact gactcttcca ttttggtcaa cgtccagata 2597641 cgttatgtca aatccgtctc cctcaagttt ttcacatgtg tgaagcacgg cgtgatgctc 2597701 aatttttgtt gtgatgatat gtctgccaag atcttttctt gcaagtgcgg ttcccatgat 2597761 cgccaagtta tcagcttccg ttcccccgct tgtaaaaatg atctcctgct ctgccgctcc 2597821 gatttctgct gcgatctgcg ctcttgcttc atccacccat tttcgagatt ctctgccaaa 2597881 tgaatgaata ctggagggat taccgaaact gccggagaag tgcggtatca tttgttccag 2597941 cacgcgctca tccatcggag acgttgcggc atgatctaaa taaatccgtt ccattatgtt 2598001 tacacctctg atctaaatat agaacatata agcttcttgc tctccgtctg tatagctggc 2598061 aagatcctct aatgttgtac tgtctaaaac ctcttttaca gcatcccgga tgcgaatcca 2598121 gagctcacgc ttggcaggct cctcatcttc cagcacttca acagggctga tcggcccctc 2598181 aagcacacgg ataatatctc ccgcagtaat ggcatccggc tcactgccta atacatatcc 2598241 gccatatgcg cctctgatgc ttttcactaa accggcattt ctgagcggcg ataccagctg 2598301 ctccaaataa tgctcggaca aattattcgt ctgtgcgatg ctttttaatg aagtcgggcc 2598361 ttcaccgtgc ttttttgcaa gctcgatcat aatggtgagc ccgtatcttc ccttagttga 2598421 tattttcaac atgaacacct ctgttatttc atgattttcc acatttataa tggtaatttc 2598481 tatatgtttc gtccgtttat tatcttatag accaactgtt attataacat accttcagcg 2598541 aattttcatt gaggcagaag gaaaggggcc tttacccttt tctaatgtac ggttttccgt 2598601 taccctgtaa ttaagtaagg agagatgata gatgaagcca ttggcatatc ggatgcgtcc 2598661 gacaaaaata gaggatatta tcggccagca gcatctggtg gctgaagata aaattattgg 2598721 cagaatggtc caggcaaaac atttgtcatc catgattttg tacgggccgc ccggaattgg 2598781 aaaaacatca atcgcaacag caatcgccgg ttcaacaagt attgcttttc gaaagctgaa 2598841 tgctgtcatt aacaataaaa aagatatgga aatcgtagct caggaagcca agatgtccgg 2598901 ccaagtgatt ttgattctgg atgaagtcca caggctggat aaaggaaaac aggattttct 2598961 attaccctat ttagaaaacg gaatgatcat tttgatcgga gcaacgacgg ctaacccgta 2599021 tcatgccatt aatccggcga tcagaagccg gacccagatt tttgagcttg aaccgttaac 2599081 acctgaactg attaaacagg cactggaacg tgcgctccat gatgagcatc ggggccttgg 2599141 cacctattct gtatccattg atgatcaggc gatggagcat tttgcccacg gatgcggagg 2599201 agatgtccgc tccgctttaa atgcgcttga gcttgccgtg ttgtcaacga aggagtcagc 2599261 agacggtgaa attcacatta cattagaaac cgcggaagaa tgcttgcaga aaaaaagctt 2599321 ttctcacgat aaagatggtg acgcgcatta tgatgtactg tccgcttttc aaaaatcaat 2599381 ccgcggctct gatgccaacg ctgctcttca ctatttggct agattaattg aagccggtga 2599441 tctggagagc atcgcaagac gattgcttgt tatcgcctat gaggatatcg gtttagcaag 2599501 cccgcaagcc ggccctagag tgctgaacgc tattcagacc gctgagcgag tcgggtttcc 2599561 tgaagcgcga atcccgctgg ccaacgcagt tattgagctt tgcctctcac cgaaatcaaa 2599621 ctctgccatt ctggcaatcg atgaggccct ggcagatatc agagccggaa aaattgggga 2599681 tgtcccgaag catttaaaag acgcgcatta taaaggagct caggaattag gaagaggaat 2599741 cgactataaa tacccgcaca attacgacaa cggttgggtc gaacaacaat acctccctga 2599801 tcctctgaaa aataagcaat actataagcc gaaacagact ggaaagttcg aatctgcctt 2599861 aaagcaggtg tacgataaat taatgaaaag aaaataaaac aaaaaaacag ccttgatcat 2599921 caaggctgtt tttatgcatt atttatcctt cacacgtttg atttcaatgt ctttcaaaag 2599981 atccatgaca acatgtccgc ccataatcaa acctgcaact gacggcacaa aagcattaga 2600041 ggaaggcggc atttttgctt tacgtatttt cgcttcgtca ttccccactt cttttctgac 2600101 atcttcccga ataacaatcg ggctttcatc agagaaaatc acttgaacgc cttttttgat 2600161 accctccttg cgtaatttcg tacgaacgac cttcgcaatt ggatcagtgt gcgtttttga 2600221 gatatcagcg atttggaagc gtgtcggatc cgttttattt gcagcaccca tgctggagat 2600281 gagcggaata tcccgtttta gacattcttt cattaaatga attttataac aaatggtgtc 2600341 tgacgcatca atgacatagt caagaccata gtcaaaaaac tgctcatacg tttcctccgt 2600401 atagaacatt tttaacgcga tcacttcaca ctccgggtta atgtctgcga tccgcgcctt 2600461 cattaaatca actttcggct gtccgacagt tgaaagcagc gcgtgaagct gacgatttac 2600521 atttgtaatg tcgacatcat ctttgtcgac aagcagaatg cggccgacgc ctgaccgcgc 2600581 gagagcttcc gccgcgaacg acccgactcc cccgactcca agcacagcaa ctgtgctgtt 2600641 tttcagcgtt tcaaggcctt cttttccgat agctaattca ttgcgtgaaa actggtgtaa 2600701 caagaacctc actccacatt cgtattctgg tttcatctat aaaatggctg atccatgagc 2600761 agccgttttt tctgcgcaca aaaaataaag tcccaatagt gccgttgcag ctttcctttg 2600821 ttttgaaccc gctctcagca ggtgggtgcc ctcttttaaa tcttgtaagt cctctttacc 2600881 gaatgaaaag aggcatgtac gccatttaaa aatgcgggct cccaaatcaa aaaaatgttc 2600941 ggtcaaaact aggtgtacaa ctaacacatc aggactttat ttaacttgtc aaaatcatat 2601001 cacagacgat tttgattttc aagaatcgaa ctgcaaattc agttcttaac ttttttcttg 2601061 atagaaagat gaagctcgtc aagctgggcg tcgcttactt cgcctggcgc ttctgtcatc 2601121 aggcagcttg cacttgccgt tttcgggaat gcaatcgtat ctctcaggtt cgtacgtcca 2601181 gcgagaagca taacgagacg gtctaagccg agtgcgattc cgccgtgcgg aggagcgccg 2601241 tattcaaatg cttccagcag gaatccgaac tgttcagccg cttcttctgg tgagaagccg 2601301 agaagcgcaa acattttttc ctgaatatcc ttttcgaaaa tacggattga accgccgcca 2601361 agctcatagc cgtttaagac gaggtcataa gcttgcgctt tcatgtcttc aggcgctgtt 2601421 tcaatcagct caaggtcttc tcggacaggc attgtgaacg gatggtgcgc tgcgtaaaaa 2601481 cggccttctt ccggatcatg ctctaatagc ggccagtcga tgacccataa gaaattgaac 2601541 aatttttcgt caatcagtcc gcgttctttc ccaagcttta agcgcagggc gccgagtgat 2601601 gcggccacaa cttcgaattg atccgctccg aacagcagca aatcaccttc agcagcatca 2601661 agtgcttcaa tcagcttaga ctgcttttct tcatcaaaga atttagcgat cgggcctttc 2601721 actccgtctg cctcaacctt cacccaggca agcccttttg ccccgtagtt tgcagcaaaa 2601781 gcgccaagag cgtcgatgtc ttttctggag taatcgccgg caccgccttt tacattgatg 2601841 gctttgacca cgccgccgtt tgctacagct gatgagaaca ctttaaattc cgtatccttt 2601901 acaatgtcag acacatccgt caaaagcatg tcaaaacgcg tatccggttt atcagacccg 2601961 tacttgttca ttgcttcgtc atacgtcatt cgaggaagag gaagctgaag ttcctcacct 2602021 tttgtttcac gcataacctt tgccatcatc tcctcagcca atgacataat gtcttcctgg 2602081 ctcataaagg acatttcaat atcaatttgc gtaaactcag gctgacggtc cgcacgcaag 2602141 tcttcatcgc ggaaacagcg ggcaatttga taatatcgtt caatgcctga taccatcaga 2602201 agctgtttaa atagctgcgg agactgcggc agcgcgtaga actcaccttc gtgcacacgg 2602261 ctcggcacca agtagtcacg tgcgccttca ggcgtgcttc ctgttaaaat cggcgtttca 2602321 atatcaagaa acccattttc atctaaaaag ctgcgaacag ctttcgtcac gttatggcgc 2602381 agctgcatcg tctggaacat agccggtctg cgcaaatcta agtaacggtg ttttaaacga 2602441 acgtcctctg acacttcttc agcttgatca gaaatcgcaa atggaggtgt ctttgcagca 2602501 tttaatacgt tcactccatc agcatgtatt tcgatcgcgc ctgttttcaa attcggatta 2602561 actgttccct cttcacgcgc caccactttt ccttgaatat caagcacgta ttcatttctg 2602621 atgccttccg caatagcaag cgcttctttt gacacatcag ggttaaaaac gacttgaaca 2602681 atgcccgtac ggtcacgcaa gtcaataaaa atcaatccgc cgaggtctcg tcttttttgg 2602741 acccagcctt tcagcgttac agattcgcca attgcttttt cagttatatc accgcaataa 2602801 tatgttcttc caaacaatgc gtttcactcc ttatcccttt tggtttgcct tcatcacatg 2602861 tataaattca tcaagtgcca cttcaatctg ttcgcccgtc tgtgcatcct ttacattgat 2602921 tttgttttgg gcaagctcat cttcacccaa aatcgcaata aatctggcct ttaagcgatc 2602981 agctgtttta aactggcctt tcattttctt attttcataa tcgatttcac tggaaatgcc 2603041 tgcttctctc agtttgtaca ccaatgaaac agaataatcc tttgcttttt cgccgagtgt 2603101 gacgatatag cagtcgattc ccttatcaac aggcagctct cttttttcag catcaattgc 2603161 ggcaagcaag cgttcgatgc tcatcgcaaa tccgatgccc ggtgcttcag gtccgccgat 2603221 ctgttcgaca agcccgtcgt agcgtccgcc gccggcaagt gtcgtaatcg cgccaaagcc 2603281 ctccgcattg ctcataattt caaatgcggt gtggttgtaa taatccagcc ctctcacaag 2603341 gttcggatcg atttcatacg aaatgccaag atcatttaag tattgtttca ctttttcaaa 2603401 ataagcggct gattcttcat ttaaatatgt caaaatcgaa ggtgccgatt tcatcagctc 2603461 atgatcacgg tcttttttgc agtccaaaat tctaagcggg ttcgtgtgca gccgggactg 2603521 gcagtctgaa caaaattctt cgatgcgagg ctcgaagtgt ttcacgagcg cttctctgta 2603581 gcttttgcgg ctatcttgat cgccgagact gtttatgaca agcttaacgt tttctaaacc 2603641 tgctttttca taaatactca tcgcaagcgc cattacttca gcgtcgattg cagggtcttt 2603701 cgaaccaatc gcttcaattc caaactgata aaactggcgg taacggcccg tctgaggacg 2603761 ttcataacgg aacatcggcc cgacataata aagctttgtc ggctgtacag gatttgcgaa 2603821 cagcttgttt tcattaaaag cgcgaaccgc agcagctgtt ccctccggac gaagcgtcag 2603881 gcttctgcct ttgcggtcct cgaaggtata catttctttt tgtacgatat ccgttgattc 2603941 tccgacgcct ctggcaaaca gttctgtatg ctcaaaaatc ggtgtgcgga tttctttata 2604001 ttgataagtg cggcaagtgt ctctcataat ttgttcaaca aactgccagc gatctgattc 2604061 tccaggcaga atatcctgtg ttcctctcgg aatgttatat cccataggta gacctcctta 2604121 tgtattcctt ataaaatatc caatgatcgt taatgatgaa aatgaaaaaa actcccgccc 2604181 ctactataca tgatagtagg gacgagagtt atacccgtgg tgccacccta gttggaatac 2604241 gttcatattc ccgctcgatc ctttaacgca ggttcacgtt cactgcctaa tggcgttatt 2604301 cacgcgttca gcaggaaacc tccggagtgt tgtttcgaga aagacgcaat gggatccgct 2604361 ttcagcctgg ggcgggttcc tctctaatca tgcaatctga cctactcttc tccattattg 2604421 gttcaaatct ttcatcattt gctatgtact caatttctat tataataatg ggattggggt 2604481 tctctgtcaa gctttattcc ggttgttttt cctcagcgct gcttctttgg acataagacc 2604541 aaattcagat gctgtttccg taagataacc agtcgtatcg ggatctgcgt gatcgctgta 2604601 atgcagattc gcttcaccgt cgtgaaatgc acgtcccatt tttggatgat atttcatgat 2604661 ttgcacacct ttttgattgt atttacgctt agtataaaca aatcatttta tttttattta 2604721 aaaatcagaa aggactttac gatattaaac aagaatgctt ttttaatgat catcagaaag 2604781 gaggacacaa tgaacaagaa atactttgtc cttattgtat gtattatttt cacctcagcg 2604841 ctattcccga ccttttcatc cgttacagct gctcaaggag aagcggtcat cgcaacagat 2604901 gaaatgaacg tcagaagcgg cccagggctt agctacggca ttacagcgga agtaaaaaag 2604961 ggagaacgct atccaatttt aaaggaagat ggagactggg tgcagataca gcttggttct 2605021 ggagaaaagg gctgggtagt ctcctggctt attacaaagg aagaccaggc cagcacaagc 2605081 tcctcaggaa gcagtgacac tgtgacatca acagaccccg atctgcggat gagaagcggc 2605141 ccgggcactt cctacgaagt catcggcaaa ttcccgcaag gcagccaagc atctgtcatt 2605201 gataaagatt cgggctggat caagatatcc tatcacagtg ccaccggatg ggtatcatct 2605261 gaatatgtca catcaggagg cagcagttca gcgtctgatg agagtgacca aaccgaggat 2605321 tccggtgcgt caacgacggg cacagtcggt gtttcttcgc taaatgtaag agcctccgcc 2605381 tcacatgacg cggcaattat aacaaaactt gatcgcggaa cgaaactgac ggttctcaac 2605441 gagaaaaatg gctgggctca cattgaggtg aacgggctaa aaggctgggt tgcaagccat 2605501 taccttttga ctagttctgt tccagctgat gattcagcaa atgccggcag ttcatcctcc 2605561 gctaaaaaag cctatatcat gtacggagga acgaatctaa gaagtgatgc gtcaacatca 2605621 gcttcgatcg ttgagcgcgc tgccaaagga gattcataca ccattaccgg ttcaaaggga 2605681 agctggtatg aaataaagct tgataacggg cagactgctt atgtagccaa ttgggtggtc 2605741 caaacgtcta aaagcgcaga agaagcaggt gaaccgccag tctctgattc cccgtctgga 2605801 aacggctctc taaacaataa aacgattatt gttgacccgg gacatggagg aaaagacagc 2605861 ggaacgatcg ggtattcggg gaaattcgag aaaaacctga cgatcaaaac ggcaaaactg 2605921 ctcgccagca aacttagatc ggctggagcg gatgtatatg tgacacgcca ggatgatacc 2605981 tttgtcagcc tgcagtcacg ggtctctacc tctcactacc gtaacgctga cgcctttatc 2606041 agcattcatt atgacagcta tgcggatacc tctacaagag gcagtacagc atattactac 2606101 agtcctgcca aagatcagga actcgcatca gatgtccact cagaagtggt gaagcgttct 2606161 tccattccag accgcggcgt attattcgga gattattatg tgctccggga aaacagacag 2606221 cccgctatgc tgtacgagct gggatatgta agccatccgc aggaagaagc cattgtacat 2606281 agcaattcat accaagaaaa agtaacagat gggatcgaaa gcggattaga gaaatacttc 2606341 caataaaaaa agctgccttt tggcagcttt ttttattttg aatccataat gagcgtgacc 2606401 ggtccggagt ttgtaagctg aacatccatc attgctccaa acgttccggt ctccactttg 2606461 attccttttt cacgaagcag gtcattccat ttttcataaa gacctaaagc tttatcaggt 2606521 ttggccgcgt tcatgtagtt cggccggcgc ccttttttcg tatctccata aagcgtaaac 2606581 tgtgagacgg ataaaatctc tcctcctata tctacaagag acagattcat tttcccttca 2606641 ctgtcatcga aaatacggag attgacaact ttatcggcta aataagctgc atcatcttct 2606701 gtatcatcgt gagtgatgcc gaccagcacc ataaggcctt gtccaatttg gccgacgacc 2606761 tcttcgtcca ctgtaacgct tgcttctgtt actcgctgaa caactaatct cttttctaac 2606821 ccctttagtt catgacgcgg cgcacagaat agatatctct aatctgttta atacgctcga 2606881 cgactttatg caagtgattg atattctgga taaaaatcgc catatggatg gttgccactt 2606941 tattgcgatc cgatttgcca gagacagatg aaatattggt tttcgtttca ttcactgcct 2607001 ggagtacctc gttcagcaat ccgcggcggt catacccaag aatctctatc tcaacattgt 2607061 attccttgcg cttttgaact tgtgactcat gttcccactc taccgggatc agccgctctt 2607121 gggcttcatt cgttttgaca ttcggacagt cttcgcgatg gaccgaaacc cctctgcctt 2607181 ttgtgataaa gccgacaata tcatcacctg gcacaggatt gcagcatttt gataaacgga 2607241 caaggaggtt gtcaatgccc ttgacacgaa cgccagcttc ccgttttctt ccttgcgggt 2607301 atggcttagg ttccccagtg acttcctgaa cgatcttttc ctgttcttcc tggtcgcgct 2607361 gctttctctc tttttctgtt aggcggttcg ccacctgcag agctgtgatg ccgttgtaac 2607421 cgaccgccgc gtacatatcc tcttcatttg agaaattaaa tttgtcagca accttttgaa 2607481 tattctccgg cgttaaaaca tccttcaatt caaaatccaa gtttttaatt tctttttcga 2607541 ccagctcacg gcctttttcg acattttctt cacgccgctg tttcttaaag aattgacgga 2607601 ttttatgctt cgcttgggat gtttgggcaa gcttcaccca atcctggctc ggaccgtagg 2607661 aatgcttaga ggtgagaatt tcaacgatat cacctgtccg aagcttatgg tcaagcgtaa 2607721 ccatttttcc gtttactttg gcaccgattg ttttattgcc gatttcagag tgaatccggt 2607781 aagaaaagtc aatcggaaca gaaccggacg gaagctcgat tacatctcct tttggcgtaa 2607841 agacatacac catgtcagag aacaaatcaa ttttgagcga ttccataaat tcttctgcat 2607901 ctgtcgattc attttgaaat tctaaaattt cacggaacca agaaagcttt ttctcaaagg 2607961 ttgcaccttc attggctgct ttcccttctt tataagccca gtgagccgca accccgtatt 2608021 ccgctatttc atgcatttca aaggtgcgga tctgcacttc aagcggatcg cctttaggcc 2608081 caataaccgt tgtatgaagc gattgataca tattcggctt cggcattgcg atataatctt 2608141 tgaatctgcc tggcatcggt ttccagcatg tgtgaatgat gccaagcacc gcgtagcagt 2608201 cctttatgct attcacaaga atacggacag ccaacaaatc gtaaatttca ttgaattgct 2608261 tattttgcag caccattttt cgataaatgc tgtaaatatg tttcgggcgt cccgagaagt 2608321 cagccttgat atttacttct tcgacacgtt tcttcacttc attgacaacc tcatcgacat 2608381 aaagctctcg ttctgcacgt ttcttcttca tgaggttgac aattctgtaa tattgctgag 2608441 ggttcaaata acggagcgcc gtatcttcca attcccactt aatttttgaa atcccgagac 2608501 gatgcgccaa aggagcaaaa atttccagcg tttcattgga gattctccgc tgtttttcct 2608561 gaggcagatg tttcagtgtc cgcatattgt gaagacgatc cgccagcttg atcaatatga 2608621 ccctgatatc ttgagccata gcgacaaaca ttttgcgatg attttccgcc tgctgttcct 2608681 cttgagattt atatttaatt ttgccgagtt tcgttacgcc gtctacaagc attgccactt 2608741 cttcggaaaa tgcttctttc aggtcatcga gcgtcacatc tgtatcttcc acgacatcgt 2608801 gcaaaaatcc gcccgcgatt gtggaagggt ccatttcaag atcaacgagt atccccgcaa 2608861 cctgaatcgg atgaataata tatggctcgc ccgatttgcg gtattgctcg cgatgagcat 2608921 cttcagcgta cagatatgct ttttcgacaa atgcgatatg ctcatcagat agatagctgc 2608981 gtgctttatc tataacttgc tcggcagtca atacttgttc gttcgccatg gaatcacctt 2609041 ttttaaaatg taaactgtat tgtagtttat tatcaagaaa aaaacgaaag atgtaaagag 2609101 cagaagttca aatagccaaa tattatataa aataaatgca aaacaatagg aaaaaagcac 2609161 cctgacatgg agtgcttttt cgttatgcgg ttatccttag tatttcatca atgttaagat 2609221 gtcgtaatct tcgagcttat ttctgccgtc aaggtaagaa agctcgatta agaaagcgat 2609281 accagcaaca acgccgccaa gttcttcaac aagtttgatt gtcgcttcaa ttgtgccgcc 2609341 tgtcgcaagc aggtcatctg taataagcac acgctgacca ggcttaatcg catctttgtg 2609401 gatcgttaat acgtcttttc cgtattccaa gccataatcc actttgatta cttcacgagg 2609461 caacttgcct tctttgcgga ccggcgcaaa acctacgcca agcgcgtaag caacgggaca 2609521 gccgataata aagccgcgcg cttcagggcc aacgaccaaa tcaatttgct tttctttcgc 2609581 atattcaaca atttgatctg tggcatagcg gtatacatcg cctttatcca tcagtgtcgt 2609641 aatatcttta aattgcacgc cctctttcgg gtaatccggt acaattgtta cgtattgttt 2609701 taaatccatc tgttttatgt cctcctcgta ctttcataag cctctgaatc ttgtttcatc 2609761 agcttattca gccattcctt cagctcttca gcagaagaat aattcagctt ttgatccagt 2609821 tccatcagct gctgtttcgc ctgatatgtt tgtgagtctg ttaagtcgcg tttctttgct 2609881 ccgctcacaa cagacagcac accattctct attttaacaa aaccgagatc aaaaaacacc 2609941 tttgtcatga aattgattgt ttcaacggac cagcctttat gttttgcaag ctctgaaccg 2610001 tgttttttca cgtcaaaagc gcctcttttc agcaagaacg cataatacca tttaaagtgg 2610061 tctcttgcgg gaaaagttga taaaaagtgg tcctcatgat tgagaaaaat aaaatatatc 2610121 cgctcgggcg cctttccttc cagcaaacgt gcgagcatgt ccagcgaagg cggcggatcc 2610181 agtaatacaa tatatgcacc atcgaggtca aacgcctttg cttgatcttt agaactgatg 2610241 acgtgcactt ctcggcgaag gtcttcagtt tgaagtaatg ttgttgagtc ttctttgaaa 2610301 gagacaatgg cccgtttagc agatggaagg gcggaaactg tgtcttccca cgtccgtttt 2610361 ccccttaaat caaacagctg ccattcagaa acagcggcat cctttatcat aagctgcggc 2610421 ttttttcgat tgttccattc gttgattgac atctcaccga caatggaaat tcttgaaccc 2610481 ggtacgatgc cttcttgaag ctcgccttta ttaaaaccga cgcaatcaag ctgggacgac 2610541 tcgtttctga tcgtcatttt gacatgagtt ttatttgccc ctatcttgcg gacatcttcc 2610601 agtactgcat tttctacgag aacgtgcggt ttcgggttca gcatgccaaa aggagacagc 2610661 atgttcattt ctgcgatgct ttcaactgta atgtcttcga cgccgcagac aaggtcgact 2610721 tcctgtacgg gaataaaatc ctcttccgta agcgtattgt ccgctatttc attcagcctg 2610781 cttcgcaaat ccggcacatc ttcggctttc agcgtcatcc ccgcagccat tggatggccg 2610841 ccgaaatgag gaagaatatc tctgcattca gaaaggctct caaataaatt aaatcctctg 2610901 atgcttcggg ccgaaccttt agcgattccc ttttcttcat caataccaag aacaatggcc 2610961 ggtcggtaga aacggtccac aagctttgaa gccacaatcc cgacgactcc cgggttccat 2611021 ccggctttgg ccacgacaat tgcagtttga tcgagccctt gctgttcaac catttcaatc 2611081 gcttcatccg tcattttgct gaccattttt tggcgctctt tgttcagctg gtcaatttct 2611141 gcggcaagct cttccgcttc aaacgaatcc tctgacataa gcaaatgaac agcgggatcc 2611201 gcctgttcga ttcttccgac ggcattcagc cttggtgcga gctgaaatcc gactgtttct 2611261 tcgttcgctt ctccgatgtc tccgcctgac agcttaatca gctcttttaa gccgagccga 2611321 tttgtccgtc gaagcctttc aagtcctagt gttgctatta atctgttttc gtcatgcagc 2611381 gggactagat cggcaatggt gccgatagcc gccaggtcaa gcagttcatc aggaagttca 2611441 cccaataaag cgtgggcaag cttaaacgcg actccaaccc cggcaagctc tttaaacggg 2611501 taagtgcagc caggctgctt cgggtggacg atcgcacgga catccggaag ctccggtccc 2611561 ggttcatgat gatcggtaat gatgacatcc agtccgagtt cctttgccac cttcgcttca 2611621 tgcacagcgg caattcctgt atcaaccgta atgatcaaag agaagccccg ttctttaatc 2611681 gaacgaaacg cctgttcatt aggtccatat ccttctttaa aacggtcagg tatataaaaa 2611741 tcaacttgag ccgacagttt ttgcagcgtg tgaagcatca ctgacgtact tgtaacccca 2611801 tcggcgtcat aatcgccata tatcataatc ttttcttgtt gtgaaatcgc ctgttttatt 2611861 cgatctgccg cttctttcat gcctttcatt tcaaaaggat cataaaaatc ggcatccttt 2611921 gtatgtaaaa acagcctagc gctttctgcc gtatcaaagc ctctttttac aagcagggac 2611981 gcaacaagag gtgttatatg caattgttct gtgagtgatt tgaccttatc ctgatctggt 2612041 cgctggattt cccatcgcat ttttgacgct aacataaatt cacccctcaa ccaccctatt 2612101 atactagagc aggctgaggg gtttcaaata atattcgaaa actagtcttt tttctcaatc 2612161 atggctgatg catcctgtgt gtcagtctga tcagcaagat gagtatcctc ttgtttatgt 2612221 attgctgttc tattttcttt ccgcaaggtt tttatttccc gcttcaattt cattacctga 2612281 aaaatgccga cagaaaatac gatcagtgct cccattaaaa ctgagcccaa aataacaaga 2612341 atgagcggcc attctgatct tccaaacagg taatcaactt ctacggatcg aacattaatg 2612401 actgcgaaaa tagcgacaat taaggtgaaa ataagtgcga aaataatggt ccattgttta 2612461 ttcattctct tttcccccaa acttcttatt gaggtaactt tcccaatcaa gactggtttt 2612521 aaacatggct taacactagg ttaagctccc tttgctgtta atttttcccg gatcagcctc 2612581 ttcagtccgg ttccctcacc ggaaatcaca agtgtatcgc cttcgtcaat gactgtttca 2612641 gagctcggat tcagttgttt atcctgattc tttttaacaa ttgcaatgac cgtcacatga 2612701 tattcctgac ccacattcaa atcaccaatc gtctgatgaa tggcaggcgc tcccgcctct 2612761 gctttacacc actctataat caaatcatca agggctgact cgacctgttc taatgctttc 2612821 ggtttatatg ccattccgcc aagaattgca gacatttgcc ttgcttcagc gtcatcaaac 2612881 tgcacggagg caacacattc ctcatggtcg ttttcgtcaa aatagtaaag ctctctccgt 2612941 ccgtcatgat gaatgataat tgaaatttta tcacggtttc tagtaatcat ttcaactttt 2613001 tgtcctatgc ccggcagctc tgattcgcga accctcatat ataaaccctc ctacatatct 2613061 gaaaaccagc cataaacact tttaacacca tatatatgtt taaatgtaag cgtatgtcat 2613121 tatagcaaat gtctatttta agttcaatga aacttcaaaa aacaggctgc cctgcagagg 2613181 acagcctgat attttttatt gcgccgaatc ttttttcagt tctcttcctt tccatgcaag 2613241 ccaaatttgt gcggcaatgt atagagaaga ataaacgcct gttaacagcc cgaccaataa 2613301 agcaattgag aagttagtaa tagaagatgc tccaaagatc agcaatgtca caacaacaat 2613361 cacaacggtt aatacagtgt taattgaacg tgtaaaggtt tgctgcaggc tcaggtttac 2613421 aatatggttc agatcggcaa aggttttcgg cttacgcttt ttcatatgct cgcggaccct 2613481 gtcaaatgta acgattgtat cgttaatgga atacccgatt atcgtcaaga tggccgcgat 2613541 gaatgtaaca tctacctcaa gccttgtaat actgaagaac gtgacgataa agaatgcgtc 2613601 atatagcaat gaggcgatgg cagcaatcgc cattttgtat tcgaatcgga ttgaaacgta 2613661 aataatgatg ccaatagaag ctatagcaac tgcgtacagc gcatttctcg ccagctcctt 2613721 accgactgtc ggtgaaactg tgctgacatt tggatcagat ccgtatttgt ctttaaaata 2613781 cgtttttact tttgcaatgg tttctttatc tggcaccccg acaaaacggg caacaccgat 2613841 attgctcttt tcgcctgaca gaactacagt atcagggtcc atacccagag attcaaaatc 2613901 cttctcaact tgctctgtcg tcagcttatg gtcgctttgc acttcaatcc gtgcaccgct 2613961 tgcaaagtca atgccaagat tcagcctgaa cacaagcagg ataataatcc cggcaaccgt 2614021 gaccgcactg gagaaaataa agaagtattt gcgtttgctc gtgaaatccc atttttggaa 2614081 tggcgtatgc ggctctgtat tttcatccgt atcctgaata tccatgatat gtttcttatt 2614141 gacaccaaac cagccttttt tccgatcaag ccatctgctt tccacaagga gagcgaggag 2614201 aaatctcgat aagaaaacgg cagtgataaa gcttgtcaaa atcgatagga tcagcattgt 2614261 cgcaaaccct ttaacagagc ttgtcccaaa gataaagagc acaaccgctg caataatggt 2614321 tgtaatattc gcgtcaaaaa tcgtcgcaaa tgaccgtctg tttcctgaac ggaaggcaga 2614381 gcggactgac tttcctagct tgagctcttc tttaatccgc tcataggtaa taatgttggc 2614441 gtcaacagcc atcccgacac ctaaaatgag agcggcaatt cccggaagcg tgagtacggc 2614501 attcatccag tcaaagatct ggagtgtaat gtagatataa acagacagcg taatcaccgc 2614561 gattaatccc ggcagacggt aatagaaaag cataaataag aaaataattg cgataccgac 2614621 aataccggca aacaccgtat catggagagc ctgctggccg aattgcgcgc ctactgatgt 2614681 cgaatacttt tcagtcagtt tcacaggaag tgcgcctgcg tttaaaatgc tggctaaatc 2614741 tttcgcttct tgagctgtga aatgaccttc aatttttaca tcagttgtat ttagttcctg 2614801 acttacattt ggagcggata caaatttagg atgctctttt tgaacttctt tcttaaagga 2614861 atcaccttta tcataatcca accaaatgac aagctggttg tttggcgcca ttttcatgac 2614921 cttcttggtc acttcaccaa atttatcagc gtctttcagc ttaatcgtga caattggctc 2614981 atttgttgtg ctatcataag tttgtttagc gccgttttcg actagatcag caccgtttaa 2615041 cagttcctta tcatttgcat ctctgaaaga aagctgcgct tcagtcgcca aaatttcacg 2615101 cgctctgttt tggtttgtca cgccagcgag ctgaacgcga atccggttat tcccttcaat 2615161 ttggatgttc ggttcgctga caccgagaac attggcccgg cggttcagtg cctctactgt 2615221 gctgaccaga acgtcttttg tgattttgtc accttttttt acaggctgta catcatacag 2615281 cacctcaaat ccgccttgca aatccaatcc taacgtaata ttgttagcgg caggcttcgt 2615341 aaagtagccc aagcccgtgc cgatcaatag aacgaaaagg aaaaacgcaa tcaagcgtcc 2615401 ttttttcatt atgtatatcc tcccttaaac ctgtgcgaat caacctgcta tctcagcagt 2615461 tcttccaatg cttcctggcc ctcttcactg cccagccaat tagacgtttt aaatgactca 2615521 acggttgcat agttcataaa ttcgccaatt ttcactgata aaatatcact cgccagttca 2615581 taaatgctca gttccgtttt ctttttccac ttcttatctg ttaagtatga ccacaaactt 2615641 tcgagttcaa catcatcata cccgagaatc ttaaactctt ccagtttgct gtaaagaaac 2615701 ggcctgacgt ggtctttata tagatcggct ggatgcttct ccacgaattc cacgctcctt 2615761 ttttattgtt tttcaagaag acttgtcatg cttggacgac atatacgcat atctttattg 2615821 tatatgattc caggtagttt gagaaggcag ggggtaaaaa tggcgaaaca gacgttttta 2615881 aagggcactc ttatccttat cgcagcagga atggttacaa gaatgctcgg gtttgtcaac 2615941 cgggtggtta tcgcccgttt tatcggtgaa gaaggagtcg ggctttacat gatggcagcg 2616001 cctactttct tcttggccac tacattaact caattcggtc tgccggtcgc gatcagcaag 2616061 ctagtcgctg aagccagtgc gcgcggagat catcaaaaaa cgaaaaatat tttagtcatg 2616121 tctctgacca ttacgggagt gctcagcctc atctttacac cgctgtttct gtttttcgcc 2616181 cctgttatgg ctgaaacgat gctgacagat aagcgaacac tgtatccgct cttggccatt 2616241 acgcctgttg tgccgattat tgctatatcg agtgtgctga ggggatactt tcaaggaaaa 2616301 cagaatatga acccgcttgc tatgtcacaa gtccttgaac aggttgtccg catttcactc 2616361 gtggctgtct gcacaacgat ttttctccct tacggaattg aatatgctgc agcgggggca 2616421 atgctatcct cagtggcagg ggagctggca tcacttcttt atttattcgt ttgctttaag 2616481 tataaaaaga caattaaaat cagaaagcat tttttacagt caattaaaaa cggaaaacaa 2616541 acctttaccc aattaatgag cgtgtccctt ccaacaaccg ggagccgctt tatcggaaac 2616601 ctctcttggt ttttcgagcc aatcgtcgtc gctcaaagcc ttgccatcgc cggtgtggca 2616661 acagttgccg caacaaagca atacggggaa ctaaccggct ttgccatgac gctgctgact 2616721 ctgcccagct ttattacata ttctttgtcg accgcgcttg ttcctgcgat cagtgaagga 2616781 atggagcaga aaaaattgca ggtggtggaa taccgcttag aacaggcgat gcgtctctgt 2616841 ctgctcagcg gaggcatttc agttgttatt ttatttgtat ttgcggatga gctgatgaga 2616901 gtgatgtacg gttcctcagg cgcagctgta tttataaaag tgatggcccc gttttttctg 2616961 ctttattatt tccaaggccc gcttcaagct gtgctgcagg cgcttaattt ggcaggagct 2617021 gcgatgatga acagcttaat cggagcgctt gtcaaaacag gccttatttt tgtccttgcc 2617081 acaaggcctt ctcttggcat tatgggcgcg gcattagcca ttgtgacagg catggtgctc 2617141 gtcacgctat tgcacgcagc aaccgtaagc aaagtgctgc cgatcagcat caaaatcaag 2617201 gagtacgcgc tcagcttcgc tgttattgta atttgcggat tcatcagctc cgccatcaaa 2617261 caatatataa gctttggagc atctgaggct gtcaatctag ccggatggat tgcggcgagc 2617321 gccgccattt atatgatcct cctgctcgtt ttccgtttaa ttaaaaaaga tgagcttcgc 2617381 cgcattccca ttatcggacg gttgatcatc cgataatggt cacgtgcggt gcccatcttt 2617441 ttcatcaata tatatttctc cgtctgtaaa cgagcaaaat gaaatatctg aagggtttgt 2617501 gtatccgtgt ttttgcaaac tttcaagcag ccattttcta tctttactga ttctggacag 2617561 gttttctgtt tgaatgaagc cgtctataat gagcggcatt tcgagctgcc gatgctctcc 2617621 gctgttttct ttcttaacaa tagtcagttt gcccgacggc tctaaaatag caaatgatac 2617681 gtcagctact ctgtcgatgc tattttctct gagctgaacc attaaatcat caaaattata 2617741 acgctgtgat ttcatggctt cttcgtcaat ttttccatat ttgataatta tggtcggctt 2617801 accgtcaaga agctggcgga cttttcggtt ttttaaagaa aagtatgcca aagtcacttg 2617861 aatgatcatt aatacaagca ttggcaaaat ggtatgaaat agatgatcgt ctacgttttc 2617921 tatggctaaa acggcaattt cagccatcat gataaagaca acgagatcta aaatactaag 2617981 ctctccgatc tcccgtttgc ccatgaaacg aaaaatgacc aatatcacaa aatacaatac 2618041 gactgtgcga aacgcaatag tgagaagctc ttccattatg cacctccaac tcattatagg 2618101 ttgcaacaaa atgatcaatt tatgtaagaa aaaccgattg catttcacaa agcttttacg 2618161 tctaattcat gggataaggg aatacatttt tacaaagacg agccatcagc atgtctgacg 2618221 gttttgaaca aaaagaacag aagcctttta atacaggcag agaggagaca atcatggagg 2618281 aaacgaaaca agttggaaaa ggcattcttt acggcttaat cgccatattt tcagccatgc 2618341 tcctgacaag tttagcggtt tcacttttat tgaccgcaac ctcgctggaa gaatcatcat 2618401 ttaactggct gatcaccgct atctcatttc tctctttatt tatcggcggg ttcatttcag 2618461 gcgggaaagg caaggaaaga ggctggatga ttggcgcatt gaccgcctta agtttttctc 2618521 tgattatctt attgtttcag tatttaggat tcggaaagac atttacagca gaacagctga 2618581 tcttccatct gggattttta ggggtgtgca tgctgggcgg gattttcggc gtgaacatga 2618641 ggggaaacag gtcttccaca taaaaaagag cgggctcact tgcccgctct tttttgtttg 2618701 ctatgtatag ctcctgctgt tattcagcag cagaaacttc tctgatcgcg cggcggtcga 2618761 acgtaagacg tgtgttatca ccagtcttaa ttacgacttt gctttcgtcg atagagtcaa 2618821 cagtaccgtg caatcccccg attgtcacta ctgaatcgcc ttttttcagt tcctcttgca 2618881 tttggcgtac agccttttgc tgcttttgct gaggacgaat cagcaagaag taaaggaccg 2618941 caaacattaa aataatagga accaatgtac ctaaagtgcc agtcatcatt ttcacccctt 2619001 tctgtaagcc tgttatgttt atttagaagc ttttcgcatt tggcttgtta tagccgtaac 2619061 gctcaaagaa ctcttctctg aaatcaccca gacgatcctc gcgaatagcc tgtcttacct 2619121 gctccattaa gtgtaacaga aaatgaaggt tatggtaagt tgttaatcga aggccgaatg 2619181 tttcattgca gcgaatcaag tgcctaatgt acgcgcgagt gtagttttta catgtatagc 2619241 aatcacactc ttcatcaatc ggacggaagt ctctttcaaa tttcgcattt ttcatattga 2619301 gtcgtccttc agcagtaaac actgtgccgt ttcttgcaat ccgtgtaggc agcacacagt 2619361 caaacatatc gaccccgcgg atcgctccgt cgatcagtgc gtccggagaa cctactccca 2619421 tcagatatct cggtttatcc ttcggcaaga gcggtgttgt gaattcgagt acacggttca 2619481 tgacatcctt cggttcacct acagacaatc cgcctatagc atatcccgga aaatcaagcg 2619541 aaatcaagtc cttcgcactt tgtgtccgca gatcttcata ttctccgcct tgtacaatac 2619601 caaacagccc ttgttcatcc tgacgattgt gggcattcag gcagcgttcc gcccagcggc 2619661 ttgtccgttc aactgacctc ttcatgtagt cgtactccgc cgggtatggc gggcattcgt 2619721 caaacgccat cataatatca gagccgagtg cgttttggat ctccatcgct ttttccggag 2619781 ataaaaacag cttgtctcca tttagatgat tgcggaaatg gacaccctct tcctctatat 2619841 tacgaaactt gcttaaagaa aagacctgaa aaccgcctga atctgttaaa attgcgcggt 2619901 cccagttcat aaatttatgg agcccgcccg cttctttgac aatgtcttgg cccggacgaa 2619961 gccatagatg ataagtgttg ctcaaaatga tgcctgcatc cattgctttc agctcttcag 2620021 gcgacattgt tttgactgtc gccagtgtgc cgaccggcat aaaaaccggc gtttcgaagg 2620081 agccgtgagg cgtatgcact ttgcccagcc gcgctcctgt ttgtttgcat tcttttataa 2620141 attcatagcg tattggttgt tcagccactt ttgatgaggc ctcctgttct caaattatat 2620201 aatcagcatc gcgtctccga agctgaagaa acggtattcc tcttccactg catggttata 2620261 ggcacgcaga atgttttctc ttccagcaag cgcgctgacc agcataatca atgacgattt 2620321 cggcaaatgg aagtttgtaa tcattccgtc aatggcttta aattcatagc ccggataaat 2620381 aaaaatagat gtccagccgc ttgatgcttt aaattgcccg tcatgttctc cggcaatcgt 2620441 ctcaagcgtg cgtgtcgagg tcgtgccgac agaaatgatc cgaccgccat tttctcttac 2620501 tttgtttaag gctgcagccg tttcttctga catttgataa aactctgcat gcatattatg 2620561 ctcttccact tcatcggcac tcacagggcg aaacgttcca aggcctacgt gcagtgtgat 2620621 gaactcaatt tgcacgcctt tgtctttcag ctgctgtaag atttcttccg tgaagtgaag 2620681 gccagctgta ggcgcagcag cagagccaat ttcttttgaa tacactgtct ggtagcgctc 2620741 tttgtcatca agctgttctt tgatatatgg agggagcggc atctctccaa gggattcaag 2620801 cacctcgtag aaaataccgt catattgaaa ttccatcttt ctgccgccgt gctcaagctc 2620861 ttccgtgcag attgccttca atcttccgtc tccaaatgtg acaacagttc cttttttcac 2620921 ccgtttcgcc ggtttggcaa gtgtttccca tttatcaccg gtttcctgtt tcaacaaaag 2620981 aagttccact ttcgcgccgg tatcctcttt tgtgccgaat aaccgcgcag gcagtacccg 2621041 ggtattgttc aggactagac aatcgccttc gttaaagaag ctgataatgt gtttaaacga 2621101 gctgtcagta agctctcctg tatgtttatc gagcaccatc agccttgaag catcacgctg 2621161 ctccaacggt acttgtgcaa ttaaacgttc tggtagttca aaatcaaata aatcgacttt 2621221 catgatgatt tcacctttat tctagtcttt tgttatttca ttctgccaaa aagattaagc 2621281 aaaattgata ataccacact tataataata caagtgacaa ccgggaagaa aaacgtaaca 2621341 tttccttttt ttacaaaaat atctcccggc atcttgccga caaaatgcaa aactgctccg 2621401 ataataagca aaacagcacc aagaatcata atgatcttag gaaattcagt catatcgggg 2621461 agcctccatt tggaaatgat gataaacggc cggtgtcacg atccttccac gcggcgttct 2621521 ttgtataaat ccaatttgca gcagatatgg ttcatatacg tcttcaatcg tatgcgattc 2621581 ctcgccgatg gtagctgaaa tcgtatcaag gcctactggg ccgccgttga atttttcgat 2621641 catgcccatc agcagcttat gatcaatatg atccaaaccg aggcggtcaa cctgaagccg 2621701 ctccagcgca ttctgagaaa tgtcttccgt aatcctgctg tcacccagca cttgggcgaa 2621761 atcgcgcacc cttctcagca ggcggttcgc cacgcggggc gtccctctcg atcttcttgc 2621821 aatttcaaga gccgacggtt tatcaatctc aacctcgaat acatcagcgg ttcttgtgac 2621881 aatatccgcc agttcttctt gtgtatagta ctcaaggcga gacattacgc cgaatctgtc 2621941 tcttaaagga gccgtcaaaa gccccaccct cgtcgtggct cccaccagcg taaaaggcgg 2622001 aaggtcgagg cgaaccgagc gggcagatgg gcctttgcca atcacaatgt ccaggcaaaa 2622061 gtcttccatt gcaggataaa gcacctcttc gatcgatctg tgcagcctat gtatttcatc 2622121 aataaataat acatctcccg gttccagcgc cgttaatata gcagccaaat caccaggcct 2622181 ttcaatcgca ggccctgatg tcgtccgcaa ttccactccc atttcattag caacaatcga 2622241 agcaagcgtt gtttttccga gtccgggcgg cccgtacaga agaacatgat ccagcgtctc 2622301 ctgtctcatt ttcgccgcat ctataaacac gcgcaaattt tcttttacct tatgctgccc 2622361 gatatactgt gccagatttt gcggcctcag gctttgctct atcactgatt catggttgtc 2622421 tgcttcactt gagacgagcc gttcatccat gaacatcacc ttactttaat agtttttgta 2622481 atgctttttt cacatattgg tctgttgtca gcccaatttc ttctttaagg tgaggaagca 2622541 cctttttgat ttctttttca gcatatccga gaaccctgag ggcttcaagt gcttcttcaa 2622601 gagccgtttc cgctgtttgc ttttcaagcc tttcttcatg attaaacaga ttttcaatca 2622661 tttcaggcac aacatctgcc agctttcctt ttaaatctag aataatctgg cgtgcggttt 2622721 tctttcctac tccaggaaac ttgaccaaaa aagcttcatc ttcattttca attgcttgga 2622781 tgaccgctcc gggatcaccc gagcccaaga tggcaagtgc tcctttcggg ccaattccgg 2622841 tcacgtttaa cagctttgta aagagcgcct tctcctctct tgttgaaaaa ccataaagcg 2622901 aaaaagcatc ctctctgata tgatggtatg taaaaatcgt ttcttggctt ctctccttat 2622961 atataaacgg attcggcgtg aaaatctgat agccgatgcc gccgttctct atgacaatat 2623021 attggggaga tacataatca atcgtccctt taacaaattc aatcacgcaa attcacctct 2623081 ttgactgttc ttcattgtac cataaaaaca gccaaagtct tatagaaaag ttaacatatg 2623141 ttcgcttctc tctcattctt tcacgaaaaa aaagacatga atacatgtct tcaatcagcg 2623201 gacgctaccc gctgtatgtc ttcatatgtt cgatgacatc ctcaaactcc gcttttgtcc 2623261 gaaatggaat gcctttcagc agattttttt gcatatggct ttccagcctt tctaaatcaa 2623321 tttgaaaaaa agactgaatt ggttcggaag ctggctcagg ccgcccatga aaagtggaaa 2623381 tcactccatt atccgataca ccgatatacc cgttgacctt gctgagcgga gaaatatcgt 2623441 ccatttgctt ccggaagagc acatatccct ttttttgttc cactagcgtc catccggcat 2623501 aagctgccca aaaatcatcc atagaaaaca ctttttcatg cttatgctca atgctgacat 2623561 cgccgtccaa atacaccttt tcaagctgca catgcacctg cagcggctca tagtgctcca 2623621 cttccgcgcc aagtgcgcgg gaaggagctc ctattaaaaa tactgccgct gagcaaagaa 2623681 tgcccagcaa aagatacgcc gtgctgaatc gtttcaccct ctacacctct ttgcacacgt 2623741 ttatgattag tttgaccaaa gaggctactg cttaaccgtt ttatcaaaat ttgtctgcac 2623801 attttccctg acaaaccgtt cctccgtata cacatctgtg ctttgctcag aaattgtcaa 2623861 gaatcgcgtc agaaaggcac tgaaaaaata caatgccgca aagatccaaa tcacgccacc 2623921 tgcaccgagc ggcccaatga aaagactcac gatgcccggc gcgataaacg cacataaacc 2623981 agatcccaaa ttcaacactg acatggcagc acctttatta tcaggtgcaa gcgtcggcaa 2624041 aagcgcgctt aatgggacgt accctgctaa agccgcgccg tagcagcagg cgataatcat 2624101 gagcacccaa tactgatgcc cgatcagctg aggcgtgtaa tacagcgcca gcgtaaaaat 2624161 accgcatccg acaccgccaa accacatgac cgtattgcgc cagcctagtt tatctccgac 2624221 tgcaccgaaa atgatattaa acacaatatt cacaaaaaac agcgtccccc atatttgcag 2624281 ccattccgaa accgaatacc cgtatcgtgc taaataagta ggaagaaaga tggcaaatcc 2624341 aaattgtcct atcgcattaa tcgtcttgac cactccgccg atgcctacct tagggttttc 2624401 aaacataatc gtaaatgcct tcgacagttc tttccatttc ggctgatctt gtttttgtat 2624461 cggagtaaat ttatctttgt taaaaaataa ggcaagaatt ccgcctgccg ccacaaacag 2624521 taaagcgctc caaagcgtat tgatttctcc aaaggccgga actgcatagc tggaatagaa 2624581 cggaccgagc acgttaaggc cgcacgtaaa cataaaccaa aaccagccga cggcttttcc 2624641 aagaatattt tgagaggtgc tgtatgacac ccatacgaga aaagagtatg caaacagcgg 2624701 atatcccaag cctctaagag catagctgcc caagagagcc ggataataca tatgaggaat 2624761 cgcccagccg ataaaagcgg ccgaaccgag gataaatgca agcaatccga cagtcatcgt 2624821 ttttctcggc ccccaagttt ggacaaacgt tcctgaaagc caagctgaga tggtgacagc 2624881 aatgccgtac atggtaaata acgatgcgga ttgctgcata ctgagaccat gatcaacgag 2624941 aaaaggagac agccagcctt gttcgaggcc gtctccaacc ataaagatga caacgccaat 2625001 ataaccccaa accatgtgag aaggaattcc gattttgttc aaaacatttc ctttagcatg 2625061 tactgtattc attttctcca ccgcctactt aaagtatcaa tggagtatat acccaagctt 2625121 gctgaattgt aatcctgtta gattaaaaag cgattttttc agtgtgctca atgctaacag 2625181 gcatgccaaa agcaagcgat tgctgtgctg ctctggcgat cctcccggcc tgtaaaccgt 2625241 cattgccggt gcagggagtc tcctggtttg tgccgatcgc ttctgcaaaa cggagaatct 2625301 cctcctcata tgaatcctta tagcgttcaa ggaaaaagaa atgcggttta tccttcatca 2625361 caaaatcagc tgttgacacc tcaaccgttg tcggcctgct attgtcagcc gctgcagagc 2625421 ctttcgtccc gaaaacctca acccgctggt catatccgta cacagcttgg cggctgttat 2625481 caatcacagc catggcaccg ttttcaaaag tcagtgtaat aacagctgta tcaatatcac 2625541 ccagctccgc aaaagaagga ttcaccaaag ccgccccttt ggcatacact tccgtcactt 2625601 cgcttcccat aatatatctg gccatatcaa aatcatggat cgacatatcc ataaacaatc 2625661 cgcctgacgt acggacataa tctatattcg ggggttctgg gtcccgggac gtgattttta 2625721 ataaatgagg tgtaccgatt tcaccatttt caacaatcgt tttgattttc ttaaaatgag 2625781 gatcaaagcg gcggttaaat ccgacttgaa gtgttacccc gtgtttccgg acagccgcaa 2625841 gcgcttcact cgtttcgtcc agagagaaac taacgggctt ctcacaaaat atatgctttt 2625901 tcgcctcggc tgcttctttg atcatctgtg catgtacggc tgtaggagag caaataaaaa 2625961 tagcatcaat atcaggatca tgtaataaat cacgataatc agaggttatg tattcaatct 2626021 gatgactgtc ggcccagctt tttatacggc tcgcctgaat gtcagagatt gcttttattt 2626081 tcatgtgagg aatccggctt atattttgaa catgaagttt gccgatgcgg cctgcaccga 2626141 taatccctgt cacaatctgt tttgtcatgg cttcttcccc cttgatcatt cacgaaagcg 2626201 ctttatttaa aattaatact atcccatttg taagcgcttt tcaagaatgg aaattaaacg 2626261 ttctatgtct cttttatcac aattcatgct tataagtagc cttcttcttc aagaccagat 2626321 acactagaat taggctcttt ttcctgaaca gtttatgatt ttcctataaa cagctgcata 2626381 aaatagagca aagaaggtga atgaaatgct gacaaaagca gaggcactgg cccataccgt 2626441 catataccgc aagaacagca gatttgataa agtcaaagag aaatccgagg aattaacact 2626501 aatcggcaag ggaagaagcg cctatgtgtt tgccttaaca gaaggcggtc gaaaaatggc 2626561 gctgaaagta ttttttccgg aatatcaagc gacagcagtc aaagaagcag cgatctatga 2626621 aaaattagcc gggtccgcat tctatcctga catttacgaa actggcgatt catttattct 2626681 catggaatat attaaaggtg aaacctttta taactgtctg aagaaaggca ttgcaatcag 2626741 tgatgacatg attcagcagg ttgaagaagc gctttctgac gcccgggcag ccggactgaa 2626801 cccgtcagat attcatttgc ggaatctgat attgacagaa accggggcgg tgcgggtgat 2626861 tgatgttgcg agatttgagc agacaaaaac atgcacgcag tgggacgact taaaatccgc 2626921 atatcatgca ctctacaaaa aaccgatatt ccccaaaaag attccgggtt tttggctgga 2626981 gatcatcgca tttttatata agaaagattg gtttcaaaag catttcgcac agcggaaaag 2627041 aaaatattct taaatcaaaa aggcagccgc acaagcggct gcctttatca tgtatttttt 2627101 actttctgac ggcagaaatc agtttcattt gttcaggcga cagcttaatt cgatagcctc 2627161 tcacagttaa gtagaccgct tctgggtcct tctcgccgga atgacaatac gttttttcca 2627221 tttctgtctc ccctcaccct ttattggctt tatttcatct tatcattgct ttattgaggt 2627281 aattttaaag aaatgtaaag attatatgaa tccgatatat agtaaaatga gagaaaaaaa 2627341 gggagagagt cacattaaga ccgaaaacac cttgagctta gatgcagcca gaggtgaact 2627401 tgtaaatgaa aaaacacttg tcaagagaac aatctactgg aattacccgg acagccgccc 2627461 agcagtgacg tggatcaatc acaatacagt gaaaatcggc aatcagactt tacatcttga 2627521 tactgatgaa acgtatgatt ggcgaaaaga tgatcattgg atccgtgaag aaccgccgca 2627581 ggcgtcagtg aggtgatgaa acatgaataa gatgaacgga acaaatgatg aaaagcattt 2627641 caatcatttt gtgattgctt tatcctttat atacggtttg actgaactag gctatttgtt 2627701 gctgaaggat tttataacaa ttgccataag tttgcctctg tagaaaaacg cagcgtagtc 2627761 gatacgccgc gttttttctt tttcccttcc tcttcttatt gataattaca ggtcatataa 2627821 tgtgacaaat cgattgtaga aatagttcga ttagaccaaa atccttttta tacatgtatt 2627881 cgaatttgaa gtgaggggga agcttgatgg cagattttgt tgctagtttg aatgcggtct 2627941 tatggagtac gcccgtcatt tatattttat tgggaattgg attcgccttt tcaattatga 2628001 cccgtttttt acaagtccga catttaaaag aaatgattgt tcagatgttc aaaggcaaga 2628061 gctctgaagc cggcgtttca tctttccaag cgttatcgat tgcgctgtcc ggccgtgtgg 2628121 gcacaggaaa catcgcggga gtggcgacag caattgcatt cggcggaccc ggtgcagtgt 2628181 tctggatgtg ggcgattgcc tttatcgggg cggcgagtgc ctttgtagaa tcaacgcttg 2628241 ctcaaattta caaagtgaaa caagacggtc aatatcgggg cggccctgct tattatatag 2628301 aaaaaggctt aggcattaag tggtttgccg tcttatttgc cgctgctgcc cttattgcaa 2628361 tggcctttct aatgccgggc gtacagtcca actccattgc ggctgggatc caaaatgcat 2628421 tcggcatctc tcctttcgtc acagggtgcg gtctggtttt attattaggg ttcattattt 2628481 ttggcggcgt caaacgaatt gccaatgcgg cgcaaatgat tgttccattt atggccattg 2628541 gatatatcct gctgtctttg attattattg tcatgaatgt gtctgaattg cctgctgtga 2628601 tctcattaat attcaaaagc gccttcgcat tggattccgc ttttggcggc ttgatcggta 2628661 tggcgatttc ctggggcgtt aaacgtggca tttactcaaa cgaagccggc cagggaacag 2628721 gcccgcatcc ggcagctgct gcagaggttt ctcatccggt caagcaggga ctggttcagg 2628781 cattttctgt ttatattgac accttgtttg tatgttccgc tacagctttc atgatcttgt 2628841 ttaccggcat gtacaatacc caggctgcag atggttcctt tatcgttcac cagcttaaag 2628901 gcgtagaagc aggacctggt ttcacacaag cggcaattga cagtgttctt cccggattcg 2628961 gtgcaggctt tgttgccatc gctttattct tcttcgcttt tacaacaatt atggcgtatt 2629021 actacatcgc agaaacaaat atcgcctatt tagcacgagg cagagaaagc aaatgggcga 2629081 tgcttggctt aaaactgatt attttagccg ccacgttcta tggtactgtg aaaacagctt 2629141 cacttgcttg ggcattaggg gatgcagggc ttggcattat ggtatggctg aacgtcattg 2629201 ccattgtgct gcttgccaag ccggcgctcc ttgctttaaa ggattatgag cgccaaaaga 2629261 agcagggctt agacccgatc tttgatccaa aagcgctggg tatcaaaaac gctgatttct 2629321 gggagaaaga atacactcat gaaagtgaac gtgtctcctg aacatactaa aaccggcccg 2629381 atatgacctc gtgccggttt tttatgaacg atagtttgta tacacttctt gaacatcatc 2629441 gtcatcttca aggacgtcta ttaatgtttc cagcttctca acagcctgat catcggcttc 2629501 tgcataggta ttgggaagca tggtcacctc cgccgaagaa attagatatt tcgattcgag 2629561 ggctgttttc acctcttcaa aatgctcagg ctctgtgaaa acctcatata ggtcttcttc 2629621 aattcgcagc tcttctcctc ctgcttcaag cacatcaagc atgagctcat cttcttctat 2629681 ttgccgttca gtacggtcta tcgtaatgaa cccctttcgt tcaaataaaa aggctacaca 2629741 tccgctttct cccagacttc cgccattttt attaaaggct gtccgcacat ttgacgccgt 2629801 tcggttttta ttatctgtta cgcattcaac catgacggca atccctgaag ggccgtagcc 2629861 ttcataggtg atttcttcat agctgcttcc gtcttggcct cccgcagctt ttttaatggc 2629921 ccgatctata ttttcattcg gcatattggc gccttttgct ttttcgatga caagacgcaa 2629981 tgctgaattt gcttctggat ccgctccgcc ttctttcgct gccacataga tttcttttgc 2630041 cagcttcata aatattttcc cgcgctttgc atcctgtgca ttttttcttt tttgaatgtt 2630101 tttccacttg gaatggcctg ccatgttttc accttctttt acattttcta tgtacacttt 2630161 aatgggaaat gttcgctgat gcaaagaaaa aggctgccga atatcacttc cggcagccct 2630221 tccttcctag cggttgttca ttttatgaag ttttctgaac agccctttat ctgttgatac 2630281 ttggacgtca cggccatttg catagttgcg cgctgctttt acaacattat ctctgtcaga 2630341 ctttgtgaac tctctgtggc ttttgactgc gataactact cggtcatccg ataccataac 2630401 ttgtgtgtca ttgacgtttt tcacttgttt cacacggttg gcaatttttg cagccagtct 2630461 tctgttttct tggttgtcat acccgttgtt cgctgcattc cgattcatgt ttcggttatt 2630521 cgtgttgtta tatgttccgt cagttgccaa aggaacacga tcgtcagcag taacacggtc 2630581 acggttattt acattcgtgg tgtttcggtt accgtcgttc tgatcctcca ttaattcaga 2630641 aacaggacca tcgtggtcga ttccgtctcc ctgtctatcg gcgtcatttt catttgtata 2630701 atatccgatt ggacgggtat tgccgttatt gcgcgtatca ttcatagcat tatcgtttgc 2630761 tccgcatgct gttaagccgg ctgtcattag aatcaggcta gcgatcgtca tttttttacc 2630821 caatggaaaa accccccgtg gacgaattga gcatgtttgc tcgcttttat catgtgcgta 2630881 tggggggcat gttaagcgtg tcagttctct ccatttggca gtgatctgct tgaaaacaaa 2630941 aaaaggaacg atttacatcg ttccgaacga tcactcattt tcttcttccg gacggccaaa 2631001 catttggttt acagaaggct ggttcgtcat tggcatagaa actcctgccg aatatgggtt 2631061 tggatttggg ttagctgtgc catatggcat attagggctt ccataagctc ccattcccga 2631121 atggccaggt gcagagaaat atggctgatg atcaccgtca cagccgcagt cgtcatgatc 2631181 tttgtatggc atgtaaccat gagccgcagc aggctggtat gctcccatta cttggggagt 2631241 gccgtaataa gggccatacg gcatatgtcc atacggagat ccataagccg gagatgcgta 2631301 ttgcggcgca ccgtatgaac cgtaatgtcc gtgatggctg ttttcatgat gctggttttc 2631361 ataacccggg tcatactgag gcgatacaaa gcctggctgg tatccatgca tcggatgcat 2631421 tggataagct tgtgccggat agtacggata gcataatcct gatcctggaa gaattggcga 2631481 aacaggcacc ggacacggta cgaaatgagc cggataatga taataaggct gaacagccgg 2631541 catcggcata ttcggaactg tgtgatgaac gttttcctct tctataccgc ctacctctgg 2631601 cgcctttggc atattaggca tattcggata atttgcattt tccatattac tcatagcctc 2631661 ctgttgtgga aattggtctt gcatatgata catatgatcc atatttccgt catgatgttt 2631721 tttcggctcc tccggtttag gaggcgacca aggctggaaa agctgtttca tatcataata 2631781 atcgttcaca tcagcttcag ggtacacatt ttcctgcaaa ttaggcatcg gcgggacata 2631841 cggcatggac ttcttttctt tcggctttgt gtcttctaca tcgacaacgg atttaggctt 2631901 ctctttcgca tatggatgtt cttgcttcac actcccggcc gcaggacttt tgcccgcttt 2631961 tggctctttt ctgaccggga ctccttctga cggcactttt attttcattc caggcatgat 2632021 taagtctgga ttgctaagct gtgtattgag ttttttcact tcctcaacat cgactccgta 2632081 cttttcagct attttccaga gcgaatcgcc tttttgaacg atatggattt tcaacgtttt 2632141 cccctcctat gcaaaacgtg aacagttcag ctgtgattac aatatgtttc ttcacaacat 2632201 atgcctgaac aaaagaagtt atgagtaaag gaagggaaaa tatttctgat ctacgtgatc 2632261 gaaagcattc gattcagggc aaggagtgca tcttcctgaa tggcttttgg caccttgatg 2632321 acgcctgaag gttctccttt ttcaatttgt tccagcgacc acaacaaatg cggcaaatca 2632381 attcggttca ttgtcaggca agggcacatg tcagggttga gtgattcgat ttgtttatct 2632441 ggatgctcgt gaatgatccg ctgaacaaga ttcatttctg tcccgattgc ccacttgctt 2632501 cccgccggag cctggttgat tgtgtcgata atatatttcg ttgatccgtt atcatcgctt 2632561 agtgtcacga cttcgtgtga acattccggg tgcacaatga tctgaatgtc ggggtctcgc 2632621 tctctcatat catggatatt tttagtggtg aatttctcgt gaacagagca atgccctttc 2632681 cacaaaatca ctttcacatt cgtatgcccg gattcagcta ctaattcatc tttcatcgga 2632741 tcccacacag ccatatcttc aagcgcaatg cccagatcat aagccgtatt tctccctaaa 2632801 tgctgatcag gcaaaaataa aattcttttt ttctgtgtaa acgcccattc aagcactttt 2632861 ttcgcattcg aagaagttac agttgctccg ccatgctttc cgacgaatgc cttgatctcc 2632921 gcagtggagt tcacataagt taaaggtatg atcgtatctc caaatatatg ctgaagcttc 2632981 ttccatgccc tattggtctg ctgcatgtca gccatgtcag ccatagaaca tccagctctc 2633041 atatctggca ggacgaccgt ttgctgctcg cttgtcagca tatcggcggt ttctgccata 2633101 aagtgaacgc cgcaaaatac gatataatcc gcttctttgt ttttttccgc tacttgggcc 2633161 aattgcaggg agtcgcctgt ttggtcagca aattgtatca cttcatcctt ttgataatga 2633221 tggcctggta taaagagcct gctgccgaac tttttcttaa tggcggcaac gcgcgtttcc 2633281 atatcctttc tcgatagttc tttataactt tcgggcatca tatcattcga ttgtttgatc 2633341 acatcaagaa ttgacataac agcattcctc cacagattca tttgataacg taacatccat 2633401 gctgatatct aaacttttga cggaatgagt cagaaatcct aatgaaatat aattcacacc 2633461 cgtcccttta aaagcaggca aagattctaa cgtaatcccg ccagaggctt cagtttttat 2633521 attagccggt gtgagctttg caaaatgacg gaccgtatca ggcggacagt tgtcaaacat 2633581 aataacatcc gctccagctg caattgcttc ccgcagctgt tcctccgttt caatttccac 2633641 ctcgatattt accatgtgcc ctgcggcctg acgggctttt ttgcacgcct ctaaaataga 2633701 gccgcatgct gcgatatgat tatctttaat catgatgccg tcatacaaac cgaatcgatg 2633761 attatacccg ccgccggctc tgacagcata tttctccagc attctgagcc ccggtgttgt 2633821 ttttctcgtg tcacaaattt taatctgttc atcatccaga caccgaacag cctctcttgt 2633881 cattgtcgca attcctgaca gcctctgaat aagatttaat acgacccgct ctcctgaaag 2633941 gagcgcagct gcgggaccgt gtaactcggc aatcacttca cctttatgca acatgtcccc 2634001 atcttttttg tgtaaaatgc tttgaacatt ttcgtccaat aacgaaaagc cttcttttat 2634061 gatcgctgct cctgcaaaaa taccctctga ctttgcaaca atctccgctt cacagctctg 2634121 ttctccaaaa atagactgcg atgtaagatc ccctgtccca atatcctcaa gaaaaaagtg 2634181 attcagtaat tttttcagct gtaaatgatt cattgttcca aatcccctcg ttttttctga 2634241 tcttcgttcc tttttttgta tggacaattt gtcttccttg ccagctcacc tcagcatgag 2634301 gaaaatcggt gcggaagtga gcccctctgc tttcctcccg caaaagcgca gaaaacgtca 2634361 tcagctttgc agtttgccat agatgagaaa gttccatctg ccgaattgtg atatccttca 2634421 catttacttc ctgaaaaggc agcgtatgaa gccagatgct aagctcaatc aaactgcttt 2634481 gttcccgcag aatagacatg tggcttgtca ttttgctttg cagttcatgc ccctctatat 2634541 ccggcacctc gtagaagaca ctggtttcta gccctgattg atattgcctg ttataaaccg 2634601 gtttttggat aatatgctct gctgcccttt ttccaaatac cagcgcttcc aataaagaat 2634661 tgcttgcaag ccggtttgct ccatgtaaac cggagcatgc tgtctcgcca atcgcataaa 2634721 gccccggcac tgtcgtttct ccccagcgat taactgaaac acctcccatt aagaaatgca 2634781 ttcccggagc aacaggaatt tttccgctgt ggatatcaat ccctgctttt tcacaaatag 2634841 cggtgatggt agggaaacgc gtttcaaaat cagaaatcgc actgaagtct atataaacgc 2634901 gatttccttt tgccatttct tcgtgaataa cccgtgagac aatatctctt ggagccaggt 2634961 cacctaaagg atgccgttca gccataatcc tgcggccgtt ttcgtctact aaacatccgc 2635021 cttcccctct gacagcttct gaaacaagcc cgtaggaaac accatttttc acaagcagtg 2635081 tcgggtgaaa ctgagtaaac tccaaatccg ttaattccgc cccggcccgg taagccagag 2635141 aaagaccgtc acctgtgaca gtgagatcat tcgtatggtg aagaaacagg tttccacagc 2635201 cgccggcagc cagcacaact tcgtctgcgt gccttacctt gagccgccct ttgctgtctt 2635261 ttgtcatgac gccgatacat cgtccgtcct ctataagcaa atctgctgcc gtttcattct 2635321 cgattaactt gattttgctg ttgatccgtt tgagcaaata atcgataagc agcctgcctg 2635381 ttgcgtctcc gcctgcatga aatatgcggt tgtatgagtg ggccccttct cttccaagac 2635441 aaacaccgcc tcgttcattg cggtcgaatg gaaatccacg ctccaatagg ctttgaacca 2635501 tcatttttcc atcatgtaat acgtctgcta caatagctag attattatgg ccgcaccctg 2635561 cgtataacgt atcctccaga tgggcttcaa tcgagtcatc ttttgcatag gccgcagcaa 2635621 tcccgccttg tgcatagaca gaattgctgt ttttgacgct tttttttgtg ataacagtca 2635681 cttcgtatga gggcgggaaa gctgcagcta aggaaagtgc cgccgcccct gaaccgatga 2635741 ctgcaatcgt ctttttagac atatgccatc ctcctgttgt ttacacctgt cttgacacct 2635801 atatttacac aaggataaaa taaactcaag agttttttat ggagaacgga tggaggaaga 2635861 ccggatgatt tatttagatt atgcagcgac aacgcctatt tgtgaggaag cccttactgt 2635921 atatcagaag cttagtatgg atatgtacgg aaatgccagc agcctgcatg atgcaggagg 2635981 aaaagcaaag cacatactgg agtactgccg tgaaaaaatc gccaacatca ttggcggaga 2636041 agcaagcggc atctatttta caagcggcgg cactgaatcc aattttctgg ccattcaatc 2636101 attgttaaac ggcctgccaa aaacgaaaag acattttatt acgactgcca tggagcatca 2636161 gtccattcat aattgcgctg cttttttgga acagcaggga tatgatgtaa cagtcattga 2636221 accgaatgaa tacgggctta ttaccgagga aatattacta acccatatcc ggccggaaac 2636281 aggccttgta tctattcagc atgcaaattc tgaaaccggg atcattcagc ccattcaaca 2636341 cctgtcttca tacctgcaca ataaggggat tcttcttcat tgcgacgctg ttcaaacgtt 2636401 tggaaagatc ccgatcaata caaaaaatct gggagtagat gcactctcaa tgtccagcca 2636461 taaaatccac ggtcctaaag gagtaggggc ggtctatatc cggccggatg tcccttggaa 2636521 acccgtttat cctctgacta ctcacgaata cggattcaga gccggcaccg taaatgttcc 2636581 cgggatcggt gccttcactg ccgctgcaga attgatcgta agcgaaatgg aaaaacagat 2636641 atcccgcaat gaggcattaa gaacatactt tctagaccaa atccgtattc ggtctctccc 2636701 tgtaaccctt gcagcagaca cttcgaaagc agaatgtctt ccgcatatta tagggtgttt 2636761 ttttcactca tttgaaggac aatatgttat gttagaatgt aatcggagta atatttgcat 2636821 ttcaaccggc agcgcttgtt ctgcaggtta ccacggtccg tctgaaacaa tgaaagcatt 2636881 aagaaaaacc gaacaagaag ctctgcaatt tatccgcatc tcttttggca ggcatacaac 2636941 agctgaacag ctggaacagt tattacatac gtttacagtg ctttgggaac aaaagaaagg 2637001 agaatttgat attgaccgaa gaattaaagc taatgggcgc caacaggcgt gaccagcttc 2637061 ttctgtggct gaaggaatct aaatcaccgc tgacaggagg agaactcgca aaaaaagcga 2637121 acgtctcaag acaggttatt gtacaggata tatcgctctt gaaagcgaaa aatgtaccga 2637181 ttatcgccac aagccaagga tatgtataca tggatgcagc cgctcagcag caccagcagg 2637241 cagaaagaat catagcatgt ctgcacggtc ctgaacggac agaagaggaa ctgcagctca 2637301 tcgtcgacga aggcgttaca gtaaaagacg taaaaatcga gcatcccgta tacggagatt 2637361 taactgcagc catccaagta ggcacccgga aagaagttag ccatttcatc aaaaaaatca 2637421 attctacgaa tgctgcctac ttatcacagc tgaccgacgg cgtgcacctg catacactga 2637481 cagcacctga tgaacatcgc atcgatcaag cctgccaagc cctcgaagaa gccggcattt 2637541 taattaaaga ctaaaaaaag ccctctagtg ggcttttttt ataattggta agactggtat 2637601 gcacccagaa gcctcacttt gcagccgagt gcttcaagct cctgcatggc ccctggaatc 2637661 aatacatcat caaacgcttt ctcaatatca ataataaaga aataatggcc taatccggtt 2637721 ttagtcggac gtgactcaat ttttgacagg tttaaatttc tccaagaaaa tgcagacagc 2637781 actctatgca gcgccccgga ctgatcatcc tgcggcagca tgaccattaa ggtcgttttg 2637841 ggcctagagc tcaattttga attcacttca aaagatatgt tttcatcggg agacaggata 2637901 acaaatcttg tatgattgtc cctataatcc tgtatatccc gtttcacgat ttttaattcg 2637961 tatgtagaag ctgccatatc attggcaatg accccgatat tcagctcggg atggtcactg 2638021 acaaactttg ctgccgcccc ggtagaattg gcgtattcat atggaacgga aggaaaatgt 2638081 cgatgaagaa atttatggca ttgcgcaatc gcgtgtgaat gtgagtaaat tttgtcgagc 2638141 tctttccatg cattctctct tgagggatgg acgagcaagt gctggtgaat cggcaacgtc 2638201 atttcaccca cgattggcaa aggctgttca tgtattaaat agtctattgt tagattaaca 2638261 gatccttcta aagcattttc caaaggaaca aaagcaaaat caacttcgcc tgcaacggct 2638321 gcatctatac actccggaat ggtgcggtaa gcaacatgtt cggcgccgtt ttgaaaacaa 2638381 gaactgactg ctagatgtgt aaatgtagct gctggaccta aataaccgac tttcatgacg 2638441 attttctctc ccttatgcac ctgaacctaa tatttcaacc ttttctacaa aatcaaactt 2638501 cctgagctta ttcattaatg tatgaatgtc ttcttccatt gccgacgtac tgatagacag 2638561 tgtcacattt gctctgcctt gaagcggaat ggtctggtga atggaaagaa cgttgcttcc 2638621 agaatcagct accgcctgaa gaagctgaga taacgcacct gacctatcct ccaaatgaaa 2638681 gaaaagtgtg ataatttgtt cttttaccat ggtgtagaat ggaaaaacag catccctgta 2638741 tttataaaac gcacttctac ttaaatcgac cttttgaacg gcatctgcta ctgaatctgc 2638801 tttttttcga tcaagcagct ttttgacttc taatgttttt ctcattgcat cgggcaatac 2638861 atcttcacgg acaagataaa atgtctcctc tttcatttgc atcccccctt taaaatagag 2638921 agcctggcac caggctctct tttcagccaa cattgattaa tcaataaatt caaattcaaa 2638981 ttccagaagc ctgattatat ctccatcctt ggctccgcgt tctctgagtg cttcatcaac 2639041 acccattccg cgcatctgtc ttgcaaaccg tttaaccgat tcatcacgtg agaaatcagt 2639101 catcttgaat aaccgctcaa ggctgtctcc tgaaagcaca aatacaccgt ctggatcgcg 2639161 tgtaatgtta aatggcactt cttcattttc catcgtgtac atgacacggt tttgtgtaag 2639221 ctcttcctcg tcatacagcg ggaattccgg tgtgttctca agctgattgg caacctcaaa 2639281 cagaagctca cgcagacctt ctcttgtcac cgcactgatc gggaataccg gataatcatc 2639341 cgtcagcttt tctttaaagg cttcgagatt ttccgcagcc tccggcatgt ccattttatt 2639401 tgcaacgata atttgcggac gctcagtgag acgcagattg tactcgctca gctcctggtt 2639461 aatcgtaaga taatcatcat atggatcacg gccttctaag cctgacatgt caatgacatg 2639521 aacaataacc ctcgtccgtt caatatggcg caaaaactgg tggcccagtc cgacgccttg 2639581 gtgtgcgcct tcaatcagcc ctggcaaatc agccatgaca aagctgcgtc cgtcatccgt 2639641 ttcaaccatg ccgagattcg ggacaagcgt tgtaaagtga tagtccgcaa ttttcggttt 2639701 tgcagatgag acaacagaca gcaaagtaga ttttcccaca ctcgggaacc cgacaagtcc 2639761 gacatctgca agcactttta attcaagaac aatgtagcgt tcttttcccg gctcgccgtt 2639821 ttctgaaagc tgaggcgcgg gattagccgg tgtagcaaag cggctatttc ctcttccgcc 2639881 tcttccgcct cttgcaatga cagcccgctg tccgtgctct gttaaatcag cgatgacctg 2639941 ttttgtatca tcgtctgtca caacggtgcc cggcggaact ttaatgacca tatcatcagc 2640001 atttcgcccg tgctggtttt tggacatgcc atgctcgccg cgaatcgctt taaagtgttt 2640061 tttgtatcta aaatccatca gggtgcggag accttcatct acttcaaaaa cgacgtctcc 2640121 tccctttcct ccgtcaccgc cggcagggcc gcctttcggc acatattttt cacggcgaaa 2640181 cgcaaccata ccgttgccgc cgtcgccgcc ttttacatat actttgacct gatctacaaa 2640241 cataatgtcc tccgttctaa accgttaaaa actccgctag tccaacccaa tttcaatcag 2640301 acattcgtga ctcgtgattt caaaacgcat gatatcaacg tcctcatatc cattctgccg 2640361 aatatcatca aaagcagatg gatcggcaaa ggcgccgtga aaatcaaggt acagaatcag 2640421 ctgtctgtca ggatgatccg tttgaagcga aaccgttaaa tgattttcac tctctctgct 2640481 gactgcttga tcaaacagat gaaacagctt tctcatcagt ttcgccagct tttgatcata 2640541 agccgacaaa tccttaattt ctccgagaac ttcatattca agcgtcatat aatgggtttt 2640601 ccaattaaac gtaagaaaat caaacgccaa atgcggtgtt ttcaggtttg agagctttga 2640661 ttcgtgcttt gcgtctataa ccatttcttc aatcatttca aagacacggt catacttctg 2640721 taagcttaag tttcctttaa tcagctgcag cttattcatc caatcatgcc gggaatggcc 2640781 aagcagatga atcagttcgt ttgttaatgc cgtgtcgctt atattttctt cttgattttt 2640841 tgaaacatcc ttcattttcg cactcccaat catttaattt cttatttagg agtctgtata 2640901 agtgtgtatt atgaattata acagagaagg ctttgttaga aaaacaattg tttttcccag 2640961 aaatatcatg ttcctttttt ctggctttgg ttgatttgca gccaggcaga acattttatg 2641021 tattactgct tggggaacat atccagtggg tttgagatgt ttattctcat tcttggcggg 2641081 gtctgctcgc acatactctg catttcattc taggtgttta ctccgcatat tgcaaaaaaa 2641141 actccagtca tcatcgaccg gagttttttg aatcattatt gagctacagg atatacgctc 2641201 acttttttgc ggtcacggcc gaaacgttcg aatttaacag ttccgtcgat tttcgcaaat 2641261 agagtgtcat ctccgccgcg gcccacgttt tcacctgggt aaatttttgt tccgcgttga 2641321 cggtaaagga tagaaccgcc tgttacgaat tgaccgtcag cacgtttagc acctaaacgt 2641381 ttagcctcag agtcacgtcc gttctttgta gaacctactc cttttttaga agcgaaaaac 2641441 tgaagatcta atctaagcat gtagctcacc tcctatatta tgtttgtggt cacacgcaag 2641501 ttgtctttgt aatcccgttc gattgtctcc agcgaaacaa tcatgccttc aatcagcagc 2641561 tgagcttttt ggcgtgcctc tggatcaaga gattcaggga attcaaaata aaaataaccc 2641621 ccgtcctctc ctatatcaag aagcggctcg aagcccgcga gcacaatgac cgcgttaacg 2641681 gccccaaaca caacggctgt cactccggca caaacaagat cttgtccatg ttcagcaaaa 2641741 ttcgcatggc ccgtcatttc aaaagacaat atgcctttat catgagacct tctgattgtt 2641801 gcctgaatca tgcttacgcg ttgatttttt cgatcgtcac tttagtgtaa ggctgacgat 2641861 gaccttgttt tttatgaacg tttttctttg gtttgtatct gaaaacagtg atttttttcg 2641921 cgcggccttg tttttcaact ttagccgtta ctgttgcgcc ttcaactgta gggttgccga 2641981 ctttcacgtt gtctccgcca acaaacaaaa cgtcttcaaa agtaactgtt tcacctgctt 2642041 cagcagcaag tttttcgatg taaacagttt ggccttcttc aactttgatt tgtttaccgc 2642101 ctgttttaat gattgcgtac attctctgca cctcctatta gactaagact cgccagatac 2642161 cagggggctg taaaagctct taacacctgt actgagcggt tgtagcaatg gtgctacatc 2642221 cataacatta aaaaatatac caaaatacaa ggcgtttgtc aatcagtttt agtagggcag 2642281 aagcagttcc tccatggaag aattcgtccg cttatcggca aagtaagcgt gcagcacttc 2642341 attctcgtca agctggctga gcttttggcc tgatttttct ataataatcg gatgcttaca 2642401 gccacgtttg aactcggcca tcacatgata gactttatcc tccgccttta ctgtcagcgg 2642461 cagaagtttc tcaagctccc tgttttttcc gtaatacctt tcgaggagaa atctcacatg 2642521 gatatagtgc ctttgccgat attcctcaaa caaggaaaca gccagaaaga caaacaaaac 2642581 ccatgcgctg atttgcagag gaatcacgaa taaaacccag cacccgagca gcaggcagaa 2642641 gcagagcgac gtttttagat taagccggtg agccttttga aaaggcagct gtttggaaaa 2642701 caacaaaaat aacagttttc ctccatccag cggccagatc ggcagtaaat tgacaaataa 2642761 gatagaaaga ttataaaagg tgaagagttc aaaggtatgc tgatgaatca ctgagacttc 2642821 tgcaagcatc caggcggcaa actgaagcca gatgtgctga agaggtccgg caataatgac 2642881 cgcaaactct tcctttaacg gccgattccc gtgctcttcc acttcgaccg ttccgccaaa 2642941 cggcagcaaa aaaacacgct tgattctcca agaaaaaaac acagccagag cagcatgccc 2643001 cagctcatga atcaatacaa tcaggagcag acataataat gctttcatat ggcctgtgag 2643061 caagcccagc gccgcaataa tccaaagaaa aggatgcaca tggatcttta agataaggtc 2643121 gagccattta ttcaaatgaa atcacctgaa tcggatcaat aaatttatcg ccgtctttca 2643181 tggcaaaata atagacccct ttattatgat catcaagctt aatcgaaccg agctttttgc 2643241 ctttatccac aaaatcatat aaagcaacat ccacatcttt gagctcgcca tagatactat 2643301 aggtgttgtc agcatgctgc accttaaccg tcagtcccgt ttggctgtct ttgctgactt 2643361 caaccacata gccttctttt acgctatcaa tcttatcact gcttgtttcg actttaattc 2643421 cttccccatt gtcctgaaaa tcctgctgta ctttcccgga tgcaggcgcg atcagatctt 2643481 tgcctacttc aatctgctgt tccttatttt tgtgttcagg agccaggaaa gcaagcggat 2643541 ttccgaattt ggtttcgaac caatggcttg ctgaagcaaa ttgaaattca gtttcaaagg 2643601 ttttggctac ggcgggttta atctgactga cgggtccaat gtttgtttta taggctatag 2643661 ctgaaacgag aacaaggcag gccgacagaa gacatttcag gataattgaa tctgttttca 2643721 ccaatgggtg ttttccgttg aatgttggca tgttatcttc gtagaccgga agtgttccat 2643781 gcttttcctg atccgttacc atcacccagg acgggggttt ctgcttttca gaaactgtct 2643841 gagtagagaa acgttttgag ccggaaagct gctttcttct tttctctaat cgttttctga 2643901 tttcatctgc tctgtgactc attgccatca tcctttgcat tcgttgggtt tgtacatcat 2643961 atgtcttgtc catggcaaat attcggttta gtcaagaaca aagcaggcaa aaacaaaaaa 2644021 aacctgacac agcatatgct ttgtcagatt cttctctttg attctatcac attaagatct 2644081 tactccgaaa aatgacttaa tcttagccat cattcctttg ttttgctctt caagcacctg 2644141 taaaggaaca gattcaccta agatgcggcg ggcaatattg cgatatgcaa tggaagcgcg 2644201 gtttttaggg tccatcgcaa tcggttcgcc atgattggaa gctttaatga cttcatcatc 2644261 atcagccacg attccgagca aatcgatcga cagatgctgt acgatttcgt cgatatccat 2644321 cgtgtcaccg tttttcatca ggtgatttct gattctgtta acaacgagcc gcggcggttc 2644381 aatattttcc tcttgctcca gcagtcctat aatacggtca gcatcacgaa cagctgagat 2644441 ttcaggcgta gtgaccacaa tcgctttatc agctccggaa acggcatttt tgtacccttg 2644501 ctcgattccg gcaggacagt ctatgatgac atagtcaaat tcctgtttga gctcttggac 2644561 catgttttta atttgttcag gagcaacagc tgtcttatcg ctcgtttgag cagcgggcat 2644621 taaatagagc agatcatcga aacgtttgtc ttttacgagc gcctgatgca ttttgcatct 2644681 gccctctaca acgtctacca gatcgtaaat aattctattt tcaagaccca ttacaacatc 2644741 aaggttgcgc agtcctatat cagtatctac taagcatacg cgcttcccta aaatggctaa 2644801 ggcggtaccg aggttcgcag atgttgttgt cttacctact ccgccttttc ccgaagttat 2644861 tacgatagcc tcacccaatt cacattcctc cctcaagcct tgttagatca ggtcttaaat 2644921 gagccaaatg ttgaaggcgt tcaatgacca tatttccgtc tgtatctaaa taagcacatt 2644981 ccatttcgtt ccctttttga atgtggtctg gggagcgatt taacacatga ttgattctta 2645041 attgtgtcgg aagcatttca gaggcggcga tgaccgcttg attatttcca ttgaatccag 2645101 catgcgcaat tcctttcagt gagcccagaa caaaaatgtt ccctccggcc ctgactgttc 2645161 cgccgggatt cacgtcaccg atcaggagca agtcgccttt tacctgcagc acttggcctg 2645221 aacggacaat ttttgaaaca gaaataattt cggcttcctc tcttatctgc tgtgcttctt 2645281 ttttagtaat gacttcactg tcaatagaat gaacaaacaa atctttcttt gacgcaatca 2645341 attcggttag ctgttcctct tgctccttat ataaaaagcg atttcccagc ttaacatgaa 2645401 cgctgatttt ctggcctttt ccatcggtat attgttcaat tgacagcata ttctgaagac 2645461 catcgagaag ctcatcaaaa gaacacgcat catccagatg caatgttagt ccattctttg 2645521 ttccttttat tgttacatat tgctgctttt tggtcttcac aatattcacc tcaacaacat 2645581 actcatttcg tcaaaaaaag ataaaatcct ttttactcat ctctcaattc tttctttaga 2645641 ctcataaaaa acaatctaaa tggcagaaca agaataagag ctgctgcaat atttaataaa 2645701 attgtcggta taaaccggtc aagcacaaat ccgttaaacg tcataatgtc tttatgaatc 2645761 aaagactgaa tgccgaatac gtaaaattcg agcagacaga cagccagaac tgctatcaat 2645821 atcactacaa atgcgtttgt atgcaacact ttaaacgctt ttgaagccaa atagcatagc 2645881 cctgcaaaac caaacatgta aacgcctaat agacttgtat agttcatgtc atatagaaag 2645941 ccaaaaataa atccgtaaat catcgcgtgt ttttggttga taaaagccga catgaatatc 2646001 aatacaagca tcaaaaaacg cggggcgagc acttggtcat ctgtaacgaa aggaaaatgc 2646061 accaaatctg taaaaatgct ttccgcagaa aaaacaagca tcataacgaa agggagaagg 2646121 aaacgtttca cgatccttcc tcctctgtat cgacagtcgg cacgtcacgg ttaacaacga 2646181 tcacattatt taaatctgta aggtcagccg caggttttac ataagcaacc ttcgttaatc 2646241 cataggaatc tgactcgata tcagtcactt caccgattgt cagcccttct gggaaaacac 2646301 cgcctgtccc tgatgtttca ataagatcgc cttttttcac gtcttgttta tccttacgct 2646361 caataattgt catcttaaga cgttttttct ctttgtcata tccttcgatc aagccgtagc 2646421 ctttgctgcc tttttttccg gaaatttttg tcgcgactct gttattgcgg tcagtatcgc 2646481 ttaaaagctg aacagcagac gtaaaattgt taagtccgga gcttttgatc ttgccgatta 2646541 atgcgccttt ttcgtttgta acggccatat ctttcgctac gttttgctga gtccccttgt 2646601 taatggtgac ctgtttcgcc caattatcag ggcttctggc gatgaccgtt gctaaaatcg 2646661 gcttgtaatc tttaatcgat ttgacatggc caagctcgtc acgcaaggat ttgttttctt 2646721 cttcaagctc ttgaagcttg gcttcatatt gtgtctgtcc gtcaagtttt tctcttagac 2646781 gctcgttttc tttgtatgtg ttttttaaat cattgatgtt ctcaaatatt cctgcaaaaa 2646841 attcggcagg cgtatgaaaa atattttgaa atactcccgt cgtatcgccg atcactttct 2646901 caggccaggt ggtattgcgg ccgcccttca gcgaaaatcc aatcatagcc accaatatga 2646961 taatacacag aagtaatagc attaaccgct tattcggcat cgtgttacac ctcttctatt 2647021 gaactcccga ttatctagtt ttccctttga aaagatggat gtgctccagt gctttccctg 2647081 ttccgatcgc tacacaatca agcggatctt cggcgataag gaccggcatt tttgtttctt 2647141 cgctgatgac tttgtccaaa ttgcgcaaaa gcgctccgcc gccggttaac actatacctc 2647201 tgtccatgat atctgctgca agctcaggcg gtgttttttc gagtgtgctc ttcactgctt 2647261 cgacaattgt agatacagtg tcgcgtagag cgttagaaat ctcttttcct gtaatttcaa 2647321 ttgttttcgg caaacctgtg agcaaatcgc ggccgcggat ttccatgttg tcggattctt 2647381 caggagcttc tgcagatccg atttccattt taatcgcttc agccgtacgg tcaccgatca 2647441 tcagattgta cgtttttctg atgtagttga taatcgcgtc atccatctca tcaccggcta 2647501 cacggattga ctgagacgtt acgatgcctc cgagggaaat aatcgcaact tctgtcgtac 2647561 cgcccccgat atcaacaacc atgcttccag tcggttccca aactggcaga ttggctccga 2647621 ttgctgcggc aaaaggctct tcaatcggat acgcgtcacg cgctcccgcc tgtcttgtcg 2647681 catcgataac agcgcgttct tcaacagctg taatgcctga tgggacacat accattacat 2647741 atggttttct ggcaaacatg cctttatttt ttatggcctg attgatgtaa tatttcatca 2647801 tcgtcgccgt tgtttcataa tcagcgataa cgccgtcttt catcgggcga agagccacca 2647861 cgttgcccgg tgtccgtcca atcatatttt tcgcatcatt tccgacagcg acaatcgatt 2647921 tcgtatccgt ctgcaaagcg acaactgacg gctctctcac aacaattcct tttcctttta 2647981 caaaaacaag cgtattcgca gttccaagat ctataccaag gtctctagca ccaattccaa 2648041 acatatgtat gtatcttcct ttcttaaagc aaaaataccc taaagggaaa aactcataaa 2648101 ctctattata gcttaattcg acgaaaaaaa aagtgttaca aatatccttt ttcctttaaa 2648161 ctcacaaatt ttttatcccc gatcaccaaa tggtcaagca gctcgatgcc aatcaggttt 2648221 ccgcattcaa acagccgtct tgtcacttca atatcttccc tgctcggcgt cggatctcca 2648281 gaaggatgat tatgaacaca gataaaggaa gcggcagatc gtttaaacgc ttctttaaac 2648341 acctctcgcg ggtggacaat agatgaattc aggcttccga taaatacggt gcgtttatgg 2648401 atgacttgat tttttgtatt taagtataaa cagacaaaat gctcctgggt taaaaagcgc 2648461 atatcctcca tgacaagatt agcgccgtct tccggggagc gaataacgaa atgttcttcg 2648521 ttggctaatt tatgaatccg gcttccaagc tcaactgctg ccagtatttg aatcgctttt 2648581 accataccga ttcccgggat gcttgacagc tcttcaaccg atgcttcctt gagcaggcgc 2648641 agcccgtcaa atgagcgcag cagccggttt gacaggtcca aaacagattc gtgtttagtc 2648701 cctgtccgca ataatatagc caaaagttca tgattcgcta agttctcggc tccgactttc 2648761 aggagccgtt cccttggctt ttctttcatt gggaaatctt tgagttttaa tggcagatcg 2648821 tgtatgacca agcactcctt ttctttccct tcccgtttat agaaccgtca tgcccttata 2648881 tcaaaatggc gaagagctct cattgttttt gatataggaa ggcccatgac tgaataataa 2648941 tctccgtcta ttttctttac aaaaagcgcg cctcttcctt ggatgccgta tgcacctgct 2649001 ttatccatcg gctcttttgt ttcaatatat gtccaaatct cttcttcact gagggaccaa 2649061 aacgcaactt ctgtcttatc ataaaaagtc tcgctgtgat tttcagcttg aatgctgacc 2649121 gcggttatta ctgagtgact tcggcctgaa agcctccgca gcatagaagc agcttcttct 2649181 tgatcctgcg gtttgccaag acattcgccg tcaaggcata ccattgtatc agcaccgata 2649241 acgattgcat gcgggtggag atcagctaca gccttagctt tttgttttgc caaccattgg 2649301 acgttttctt ctggtgaaaa gtttcgattt aatttttctt ctacttcact gacaataatg 2649361 gagtagggca gctggagaag atcgaggagt tctttcctgc gcggagattg tgatgcaagt 2649421 attagcggtt ttgtcatgtt cgtcatcctt tcagggtttg cttaagaaaa aaagatactc 2649481 gtttatccta ccaaatcacg aggcttgtca caatttcaga aaaataactt tttcatgaca 2649541 aaataaaaaa agcctgtcac taaaggacga aggctcaggg cactatctct tattttacga 2649601 cggctaacag ctcctgctga gccttccacc cggcttcagc acttggatcc tctaattcct 2649661 ttaaagcctg caaaatcgct tttttctctc ctgtttctga cgcttttgtt tcaccaagcg 2649721 acttttctat tttctctaca ctcgcttttg taatgtcttc gtcgagaatc gcctttgctg 2649781 caagctccgc tgtttcctta aaagaatctg tcatatctga ctctattgat aaggaaagct 2649841 ccttgcctcc ccaggcttca aaatcactgt cgattaaaac ctgtcctaac tgctgtgaga 2649901 cctccttttc acttgctaag cctgcaataa catacgtata cccgtcatcc tttgacagtg 2649961 acacggcgga atatcctttt tcggtcaatt gttctgttaa cgtttcggcg cccttttcat 2650021 ttgaaaattt tccggcttgc acagcgtatg ttttgtatgt accttcagtt tgtgccgctt 2650081 gtttttctgc gcctgaggtt tgtttatcag cagaagtatc ccctgctttt gccgtttggc 2650141 tgcctaaaga atcctctaaa gaggccggtg ctgacgcttc tttattcccc gatatgttta 2650201 acgcgaataa ccctaatcca gtgccaatga cagccgcgaa ggcaatcgtc gcggccactc 2650261 tttttaccgg tttggcagcc ccggtctttc cttttgcgta aagctttgtt tttttctttt 2650321 gaaaaggagg aacaacttta gggtcctctt taaacacctt gtcctcctcg gaatcccaat 2650381 tgaattcatc ttcatcaggg tgttcctggg atgccgcaac ctcttgttct gcctgtcttt 2650441 tttcctccca atttgaaaat gtcatgcttt tattcgcctc tgtctcaggc gtctcttgtt 2650501 cgtaaaccgt ctcttctttt ccattaatcg tcaccttgag ggctttttct gcggctttac 2650561 tgtttttttt attctttctt tttttcaatt ccgcttcctc ccttcatttg cttgaccgtt 2650621 cttgtcggct tttcatgcta cacactttag cacaggcaaa gaaaaaaaga acaagacttt 2650681 tgtcgccttg tccaaaaaac gttcgtcaaa tttttcagca gtcagcccaa tgccattttg 2650741 atataaaaag aaatgataga gtcaccgtat aaataggcta aaatgctccc tgcggctata 2650801 gcgggggcga agggaagcgg ctgcctttta gcgagtctac cagtcagaac agctgccgct 2650861 ccatataatg cacctatcaa aactgaaaag aaaaaggcag ctgccagcat tttcacacca 2650921 agcacaaagc caatcaccgc aaataattta atatctcctc cccctactcc cccatgggtg 2650981 attgcggcaa ttacagccag aaacaaaaat ccggctgccg cacctaacag gcctgcatac 2651041 caggaatcaa gcggagaaat caatctcgcg gccgccaaaa agggaagaaa gaaaatcaat 2651101 attcgatttg gaatcagcat aaaatgaata tctgtcactg caacaataat gagaagagag 2651161 ataaacacca cagcgggaaa cagttccagc gatatgccaa agcgtattcc tgcggcggca 2651221 aataaacacg ctgtcacaag ctctgctgcg ggatacataa aagaaatcct atgcccgcag 2651281 cttttacatt tacctttttg aaataggaat gacaggatgg gaattaattc tgcaggagtt 2651341 aatgttcgcc ggcaaaacgg gcatgatgaa cggggcgcaa taatagatag atgtaagggg 2651401 atacggcacc cggccgtata gtaaaaagaa ccaaggataa gcccgaagat aaaaagaatg 2651461 gatagcatag acaacacacc tttactcatt gagttctggt atggattgta gcaaaatgga 2651521 catcctgagc tccaattggg aatattcaat tttacacatg aaaaaaacgg cagaatcttt 2651581 ttttgattct gccggagccg gatgctttta tttcaacctt tttcgaatgt cagaaataaa 2651641 gtaaagagat ccggtaatca gcacaatttc atttgagccc tttttacttt ctatgaattt 2651701 gattacatcg tctggatctt cactccagct tttattgctg atttcacttg catcatagag 2651761 atcttttgca agggaagcac gcgggaaatc aaaagaagca aaatgaatcg catgagcaat 2651821 ggtttccagt cttttaatca tgttctgata cggtttgtcc tttaacgcgc taaacaccac 2651881 agaaatgcgt gaattggcga aacgctgctt catcgtttcc gccagctttt caacaccttc 2651941 ttcgttatgc gcaccgtcta aatataccgg aggatgttcc tgaacaagct ctaaccgtcc 2652001 cggccaagca gccttcacaa gcccgctcct taacgcttcg tcactgatat gggcgatatt 2652061 ctccttattg agccactccg cagccaaaat ggacaaagca gcattttgtc tttgatgggt 2652121 gccaatcaga gatgtccgaa tatcttcata gcatttctct tccgttttga atgaaaactg 2652181 ttctcctgca ggcagagcct cttcattgaa aataacacat gcatcatgca atgactggaa 2652241 cggcgcagca tgccgttcgg cttcatggcg gatgacctgt aaagcttccg gctgggtaac 2652301 tgctgtaacg attggaatac cttctttaat aatgccggcc ttttctcctg caatttcttc 2652361 aatggtgttt cccaaaatgt tcatatgatc gtgtccgatg cttgtaatca cagttaagag 2652421 cggttcaacc acattagtag aatcgaatct accgcccaga cctgtttcaa aaataacaaa 2652481 atcgacctta tgaaactctg caaaatataa aaatgcacaa gctgtcataa tttcaaattc 2652541 tgtcggctgt ccgtattccg tttgatcaag ggcttcaacg tgcggtttca tttgattgac 2652601 gagtgctgtc cattcctcat ctgaaatcgg tatcccgttt acgctgatcc gttcattaaa 2652661 cgtaataata taaggcgatg taaatgttcc aaccgtatat ccggcttcct gcagcataga 2652721 acggataaaa gcgacagttg atcctttacc gtttgttcct gcgacgtgga acgctcggat 2652781 ttttttttca ggatgtccta accgcgccat cagctgtttc attcgaccaa gtccgggctt 2652841 caccccgaat ttcagcctcc cgtgaatcca gctgcgcgca tcttgatatg cagtaaacaa 2652901 tgataatccc ctcttttata agacaaggcg gtttctctag aaaccgcccc ggcttttcat 2652961 taacccttca gctcagccat tcgtttttga acagcgtcac gcttcgccac ataatctttt 2653021 tctttttcac gttcttcatc aattacgtgt gcaggcgctt ttttcataaa tccttcattt 2653081 ccaagtttct tttggacacg ctcaacttct tttgtcagtt tatcaaattc tttttgcaga 2653141 cgggcaattt cttcatcaat attgattaag ccttcaagcg gaagaataac ctctgctcct 2653201 gagacaacgg ccgtcatcgc cttatcaaca gcctcaatat cggtgccgat tttaagcacg 2653261 ctcggattcg taaagcgttc aacatatgaa cggttcgctt cgaggcggga cgctatttcg 2653321 tctgtgcttg ttttaatgta cagttcaacc tgcttgctca ttggcgtatt gacttcactg 2653381 cggatattgc gcacagaacg gatcagctca acaagaagct tcatgtcagc tgccgcttca 2653441 gtatcggtat gctccggcac tactgcaggc cattgactta ctgtaatcga ttccccttgg 2653501 tgaggaaggt gctgccaaat ttcctccgtt aagaatggca taaacggatg gagcagacgc 2653561 atcgtttgat caagtacgta agcaaggatg gaacgggtag ttttcttagc cgcttcgtct 2653621 tctccataaa gcggaagctt cgccatttca atataccaat cacagaaatc atcccaaata 2653681 aagttatata aatggcgtcc tacttcacca aattcatatc ggtcagcaag ctgggtcacg 2653741 tgctcgatcg tttcatttaa tcgcgttaaa atccacttgt cagcgactga cttttcacct 2653801 gacagatcaa gctcatcgta cgtcatgcca tccatattca ttaatgcaaa acgggaggcg 2653861 ttccaaattt tattggcaaa attccaggtc gattccactt tttcatagct gaagcgcaga 2653921 tcctggccag gagagcttcc agtcgcaagg aaataacgca gagaatcggc tccgtacttg 2653981 tcaatcacat ccatcgggtc gacaccgttg ccaagagatt tactcatttt ccggccttgc 2654041 tcgtcacgga ttaagccgtg gattaaaaca tctttgaacg ggcgctcgcc tgtaaattca 2654101 atgccttgga aaatcatgcg tgatacccag aagaaaatga tatcgtaccc tgtcacgaga 2654161 acatctgtcg gatagtagcg tttaaagtct tcagccgtta catcaggcca gcccattgtg 2654221 gagaaaggcc atagcgcaga actgaaccat gtatccagta cgtctgtatc ctgttcccaa 2654281 ttttcgctgt cttccggcgc ttcaagtccg acatatagct cgcctgtttc tttatgatac 2654341 caggcaggaa tacgatggcc ccaccacaat tgacgggaga tacaccagtc gcggatattt 2654401 tccatccagt gtaaatacgt tttttcgaaa cggtcaggca caaagttgac cttttcttct 2654461 tttttttgca gctcaatcgc tgcatcagca agcggctgca tgcgcacaaa ccattgtgta 2654521 gaaagataag gctccacaac agccccgctt cgttcactat ggccgacaga gtgcatatga 2654581 tcctcgatct tgaagagaac tcccgcctcc tgtaaatctt tcacgagctt tttgcggcat 2654641 tcaaaacgat ccataccttg atattggagc gcattttcat tcatcgtgcc atcttcattc 2654701 atgacaagga tgcgttctaa attgtggcgg ttgccaagct cgaagtcgtt cggatcatga 2654761 gcaggcgtaa ttttcacggc acctgaacca aattccatat caacatagtc atcaccgaca 2654821 atcggaattt cacgatttac aatcggcagg atcaccgttt ttccgataag gtgtttatag 2654881 cgctcgtctt cagggtgaac ggcaacagct gtatcaccga gcattgtttc aggacgtgtc 2654941 gtcgcaattt caattgagcc tgaaccgtca gcaagcggat agctcatatg atagaatgcg 2655001 ccttgaacat ccttgtaaat cacctcaatg tcggataggg ctgtttttgt cgctgggtcc 2655061 cagttaataa tatattcgcc tctgtagatc aggccttttt cataaagctt aacgaatact 2655121 tcccttaccg ctttgctcaa gccttcatcc agcgtaaaac gttcacggga ataatctagg 2655181 ccaagaccta atttcgccca ctggctgcga ataaagtcag catattcttc cttccacttc 2655241 cacgtttctt cgaggaattt ttcacggcct aaatcgtagc gggatttgcc ttcttcacga 2655301 agtttcgcct ccactttagc ctgtgtcgcg atgccggcgt ggtccatgcc aggaagccac 2655361 agcacatcat agccctgcat gcgtttcatt cttgttacaa tgtcttgcag cgttgtgtcc 2655421 catgcgtggc caaggtgaag tctccctgtt acgtttggcg gcgggatgac aacagagtat 2655481 ggctcttttg tctggtcact gcccgcttca aaaaatttgc cttttagcca aaaatcatat 2655541 cggtcttttt caaccgctgc cggatcatat ttcgtcggca ttgtttgttc attcgtttcc 2655601 atcataaccc tccagcatgt ttaaaaatgg ctgagaacga aaaaagagct cttcatccct 2655661 gtaaaaggac gaaaagctct ttcgcggtac cacctttttt catgaactca atcagttcat 2655721 gcacttataa cggataacgg gtgtttcccg aatttctcta ctcttctttc aagaaattat 2655781 gctcccgggc gaccttccaa tcagacaaca taagaagcct ttcagcaaac ggcttctctc 2655841 tctgcatgcg ccttttttgt actcttcccg ttctaagcag gtgtatttat cagctcattg 2655901 tatacattat ttatgttctt tattatagta aaagtgtttt tgattcgtca atcatctttt 2655961 ccaaaaacac cgctttctat acagatgggc aggcacctat tgcccaagtt tacatatgat 2656021 gcttgtaaat gcgtagagga ggatgcaccg tgaagaaacg tttcagctct tattcgctgc 2656081 cgccatgggt aaggcaaatt cggcttgtat ccgcacaagt gattattccc attacgattt 2656141 ttcaaggaat cagaaccatt ttctttccga caacctttga tgttttgctg ctcgcaatcc 2656201 taatcttttt agcttgcgcc cttcatttag aatggatata aacaaacaag tccgcgccat 2656261 taagacgtgg actcgttttc agcctgaaat tttttctctt gttcaatctg atgaattttc 2656321 atcacaaacg gctctatgtt tttcatttgc caataagcct ttaataattg tgtacattcc 2656381 tctttttcat gctgtctttt cccagtttga taaccgttca gcaccttgta catggctgcc 2656441 ggatatgcca tatagctgag aaaaaggctg acttccgctt cacgcaaagg gaatgatttc 2656501 gtatatccat aaaaccattc gacgcattcc ggacaagctt tcggaaagcc tctgaacatt 2656561 tttgtataaa agccgagcag gtcgttttgc ggcggaccga cagatgctct ttcgaagttt 2656621 gtaaaatatc cggtcccggc atcattatac agaaaatggt gtatagacag gctgccgtgg 2656681 ttcattacaa cccttgaaac gtccttttcc tttgcggact cataccagtc ctccagccgt 2656741 tccagcgcaa agttcaccgc ggaaatggtt tcagaaaaat aggttatggc ctggagttca 2656801 aagggagaaa ggtaccattc cttctccgct ctatccacaa actgctcata gaaaatttta 2656861 tcttgttccc actttttttt cgtttgcccg taataacgtt caatctcatc acgtctaacc 2656921 tttagttcct gcgcggttct ctcgtgaaga cgggctgttt ctctaaataa ataagcatgt 2656981 ttttgatccc gttcttcctc ttggtcaaat tggagccaag gcattaaata gtagatatct 2657041 ccgtattgta tgcctgctga gaaaaactca ccgctatttg ttctgtaaac gggaacgaat 2657101 gaacgaaagc ctttttcctc aatcgccacc atatgatctg taaaatgctt gccgcgacct 2657161 tctttcaatt ttttcagggc aaatatgccg tagtctgtat acactttcca aacaagagga 2657221 ctgacaggct caataaattg agcagtcagt ccgtattcct gaagaaccga ttgggtatct 2657281 tccatttcat tcaccacatt ttccgatcac ttacggttta cgcatggcta tttttatatt 2657341 gaggaatata gagaatctgt cctgctttta attcatcatc caaggctaaa gaattcatcc 2657401 tgatcagctg ctgggatgta atttcatacc gttcgcataa acgctcgatc gtatcttcct 2657461 gctgcacaat acaaattttc attctcgaaa actcatccgc ttcttttgta aagagttttg 2657521 ttaaataaag agaattatca ctttcctttg tttgaggttc cttcgtttca gcagcaggag 2657581 caaccctagg aacagcatcc gtttccttcc tttcagtctc agaagattca ggcagctgga 2657641 aggattgaaa aggtgtttct tccttaggct cttcagctga tggtgttttt ctcacttcaa 2657701 tttcgaagct ctcttcctct tgttcttcct cctccagcag cttaggcgct gaataaaaag 2657761 aatcctcctc ttcttgttca ggcaggaagg tacggtatgc cggttcaggc aattcttctt 2657821 gagatgcctc ctccgagctt gttttttgat tgaaatggaa atgtaaatcg gcattgtcat 2657881 tctccatata tacagctgaa gctgtttctc tgctatcttc tatggagaga gcggcctctg 2657941 atacactctc caaagcttca tccggttccg cctcttcttg gcaaagcgca ggatcagcct 2658001 gatccgattg agctgcttct tcattttgag cctcttggcg cagcgcatat tcatgattag 2658061 gagacactgt tgtttcctct ttttcctttg caatcacagt ctctgaatga agctcagctt 2658121 ccaaagcagg cgattcttct gctccaacgt gttcacgaag ctcagtctcc gctggagagt 2658181 ctgcttcttc acgaacatcc gctattgcag ctgccggctc tgccgtttct ttttttgctt 2658241 taacgatctc ttgaatctct atttctgaag gatcaggttc tggctcagat tcttctgttt 2658301 ccgattcagc acgaacctcc gtttccggca cagcaagctc ttctgactct tcttcctctt 2658361 tcacatcttc tctggcctct ggttctgaag caaccgattc aggcggctca gattctgctt 2658421 tttctgtctc cagttcttca cggagccccg ctttcgagat aaaaagttct ggcggttcgg 2658481 ctggcggttc atgctgaaga actgcttcct ctgccgatga tgcacccggt tcttctacta 2658541 cactatgtgc cggcggctct gaaagctctt cctccctgaa tgccgcagga gcttcatata 2658601 aaggtatctc cggctctttg tcttgcgtat cgtccaaaag cccttcgatc gctaaatcag 2658661 cttgaattgt taaaatgcgc gaatccgtca attgatagtc aaatgcgtca ataaagacga 2658721 agacatcctg taaatggctc actttatttt tcggaatggt aatatccaca ggaaaacagt 2658781 gagtcagttc cgcacttcca tcctctctct ttctgacttg ttcaacaaac cgcttatctg 2658841 tataaatctc ttcggtatgt ttgttttgat ctatgttgta ctcacctgta agttcaagcg 2658901 atcctatgat tgatacataa tcatttactt cctgaaccct aatatcagga tctaatgaaa 2658961 tagaaagcag ttcagaaact tcctgtcctt tttggaaaca gatcgattct tctacagaaa 2659021 attgcaatcg atgattttgc ggcaagttca tatcctcctt tcatctaatc cttaaaatta 2659081 gatgtcacta aaggtgtatg tatgaactgg agaaaatatg agtgggagag cacgaaaaaa 2659141 ccggcacaag gagtccttga taccggtttt cactcttatc tgcggctgat ctcagcaaat 2659201 actttctcag ctgcctggat tgtgttttca atatcttcat cagtatgggc cgttgagagg 2659261 aaaagacctt cgaattgtga tggcggaagg aatacccctt catttgccat ccctttataa 2659321 tagcttgcga acagcttcaa atcagatgat ttcgctgttt cataattgat gactggttcg 2659381 tttgtaaaga agaaaccgat catcgaacct gcacggttaa aggtatgcgg aatgccatga 2659441 gccccggcgg tttttgaaat tccttcttcc agtctgtcgc cttttttgat gaaattcttg 2659501 taggattcag gtgtcagctg tttcaatgtc tctaagccag ccgtcatcgc aagcgggttg 2659561 cctgacaatg taccagcttg atagatcgga ccgcttggag cgatctgctc catgatttct 2659621 gcctttccgc cataagcgcc gacaggaagt ccgcccccga ttacttttcc taaacaagtc 2659681 agatcaggcg ttacgccgaa gtagccttga gcgcagttat aatcgacccg gaagccagtc 2659741 atcacttcat caaaaatcag cagggagccg tactgctcag tgatatcacg cagaccctga 2659801 aggaaacctt cttgcggcgg aacaacaccc atatttccgg caactggctc tacaatgact 2659861 cccgcaatgt cttcaccgaa ttgctggaaa gcaagcttta cactttctaa atcattgtac 2659921 ggaacggtga tggtgttttt cgcaatgcct tcaggcaccc ccgggctgtc aggcagaccg 2659981 agagtggcaa cacctgaacc agctttaatc aagagagaat cgccgtgtcc gtggtagcag 2660041 ccctcaaatt ttaaaatctt gttgcggccc gtatagcccc ttgccaaacg gagggcactc 2660101 attgtagcct ctgttccgga gcttaccatt cgtacaattt ctacagatgg cacacgatca 2660161 atgacgagct tagccagttc attttctact tcagtcggag caccaaagct tgtcccgtat 2660221 tcagccactt ttttgaggct ttctacgacg cggtcatttg tatgccctaa aattaaaggc 2660281 ccccatgaca agacgtagtc aatatattca ttcccgtcaa tatcaaagat tttcgagcct 2660341 tttccgcgct ccataaaaat cgggtccatg tctaccgatt taaatgcgcg aacgggactg 2660401 ttcacaccgc ccggcatgag tttttgcgct tctttaaaag ccgtttttga tttttcatag 2660461 cttctcatct gcctcaactc ctgtcaactg aataaaatta ctccgcaagc catttcgctg 2660521 cgtctttcgc atgatacgta ataatcaggt cggcacccgc gcgcttcatg cttgtcaaaa 2660581 tttccaacac aatttctttt tctttgatcc agccgttctg cgctgcagcc ttcaccattg 2660641 aatactctcc gcttacatta taagcgacga gcggcaaagt aaactcattt tttacgtcac 2660701 gcatgatatc catataagaa agcgaaggtt tgacaatcaa aaagtccgcg ccttcctcaa 2660761 catctgattg tgcttcgcgg agtgcctcca tacggttggc agggtccatc tgatatgttt 2660821 tgcggtctcc gaattgcggt gtgctgtttg ctgcatcacg gaacggaccg taaaactcac 2660881 ttgaatattt aacagcgtaa gacatgatgg gaatattgac gaatccttct ttatcaagtg 2660941 cttctctgat cactgtaaca aatccgtcca tcatgtttga tggcgcaatg atatccgcac 2661001 ctgctttcgc ttggctgaca gctgtctgcg ccaaaagctc cagcgattca tcattgagaa 2661061 tgactccgtc tttgacaagt ccgcaatggc cgtggtctgt atattcgcac aggcacgtgt 2661121 cagcgacaac aaccatttca gggaagtgtt ctttaatttc tgtgatggct ttttggacaa 2661181 ttccgtgatc atggtacgct tgtgttccgc aatcatcttt ttcttccggg atgccgaaca 2661241 cgataacaga ttgaatgccc agtttgacca gctccgctac ttcatccttc aataaatcta 2661301 atgatacatg gtgaacatca ggcattgacg gaacagcttt tttgccttcc agcccttcaa 2661361 cgacaaaaat cggatatata aaatctgatg gatgcaaacg tgtttccttt accatttctc 2661421 tcattgcttt tgatgtccgc aggcggcggt gtctattaaa tgattgactc atattctctc 2661481 ttcctctctt gacatgctgc acattaactc aagcatgcca tctattgtaa atgtatcagg 2661541 cgtatgcgat gtgatgccgt acgtcagaag ggcatcattt gttaaaggcc caatgctgat 2661601 acaggccgtc ccattcgcct tccacttttt taattcttct cccaagacat gcataaacgt 2661661 atgtacggtt gatgaactcg taaatgttac atagtcaaag gaatattgac ccgcagcgtc 2661721 tttcaatgcc tcaatgcctt cttcatccgg aatcgtttcg tagagaaccc attcctttac 2661781 ttcaaaaccg agcgggacaa gctcttgttt tatcacatca cgtgacaaat tccctttcat 2661841 cacggtaatg gtctcccccg gttcagcatg ctgcttaaga gcgtcagcca attgttcagc 2661901 aatatactcc tgtggcatca catcaaccga tacgttatgc atttttaaac ggcgcgcggt 2661961 tttttcaccg acggctgcaa tttttttatg cgcagggaga ataagctgat tttccttcag 2662021 ataagaaaaa aagaagtctg ccccgttcac acttgtaaaa acaagccagc ctggcgcggc 2662081 aagatcctct cttacctgtt ccgcaacatc attcggcaaa gcgcggcgaa acgtaatcaa 2662141 agaggttaaa accgctttac cgccaagcgc ctccactttt tgctgaaatg atgctgcctg 2662201 tgccttattc cgggtgacaa gcactgtttt tcctttcaac ggaaaatcat tttccatcct 2662261 cgtcaagctc ccgttttaca cgatcaatta aatcttttgc tcctttgtca gccataagag 2662321 cggcacagcg ctttcctact tcctccggat cgtttccggt gacggtttct ttaaaaatga 2662381 ttttgccgtc aggtgaagcg acaagacctg tcatttcaat ttcatcctgt ccatttaaca 2662441 cggagtagcc cgcgatcgga acctggcagc cgccctccat cgcgtttaaa aaagcacgtt 2662501 ccgctaagac agtccgtttt gtatattcat ctgtaaactg agaaaacaac gccaacagct 2662561 cttcatccga ttctcggcac tcaatcgcca gggctccctg ccccacagca ggcaaacagc 2662621 gctcaggctc aaggaattcg gttacgacat cttgcttcca acccattctg gaaaggccgg 2662681 cagccgctaa aataattgcg tcataatcct ctgtttccag cttttgaagt cttgtatcta 2662741 tattacctct aatccattta attgtaaggt cagggcgctc aatcaaaagc tgcgcgcttc 2662801 ttcttaaact gcttgtgcca atgacagcac ctttcttcat ttctgaaagc tttacgcgat 2662861 tctttgaaat aagggcatca cgcgggtcct cccgttcagg aatacagccg atcacaaggc 2662921 cttcaggcaa aacagcaggc atgtccttca tgctgtgcac tgccatatca atctcttcgt 2662981 ttaaaagcgc ctgttcaatt tctttgacaa aaagcccttt tccacccact tttgagagtg 2663041 taacatcgac aatccggtcg ccctttgtca cgatctcttt aatttcaaaa gcaaacgaag 2663101 gattgatttc cttcagtttt tgaataaccc attttgtttg agtcatagcg agtttgctcc 2663161 gtctggaacc tactttaatc gttctcatca tttctttcct cccgaatctg cttgggacat 2663221 cgtttaactg aaccaatgga attgcgacag gcttccaagc aggaaataat tgatcatcag 2663281 caccagaaaa caagccgtat tccacagtgc agcgaccttt ccttgcagct ccttaatcag 2663341 cctgatataa agataatagc tgtacagcag caggacgaca aacgaaccaa gcactttggc 2663401 gtcaaaccaa tacagcgttt ctagtgagac atacgcccaa atgacgccga gaatcaaact 2663461 cagcagcagc atcggaaccc caatgacatt taaaacatac gccatataat caagcttaga 2663521 taaatcttct attctcaaca gccattttcc ccactttttc tttttcagca gatgatattg 2663581 aaacatatat agcacagaaa aaacgaaaga aagggaaaaa gcgccgtatg aaagaatcgc 2663641 cattgtaata tgaatcacca aaagctcgga tacaagctgc ccggaaaaag cagctgactg 2663701 ctgctctgtc ggtgaaaatg tgtgaatggc gatcatagaa aatcctataa catttgtaaa 2663761 aaacacgata aagtcaacac gtaaaagctt tgtcagtaca agtgacagcg tgacaagcac 2663821 ccaggcataa aaataaagtg cctctgtcac atttaatacc ggaaaccgcc ccgtcaccca 2663881 cataaaatag gccaaataca cggtttgcag agtccagaca atagaaagca accagaaggc 2663941 catttttcca gccttccggt tgtgttgaag aaaatctata aaataaaaga gtacacttaa 2664001 cgcgtaaatg acgattgtcc cctcattaag tcttgccatt gcagtatcaa tcattcagct 2664061 ttcactcact tacaagtggg ctaaagcccg cttttgattc agccttctta aaagagtgga 2664121 ccttctggct gctttcaacg gttttcatca tttgacggcc cgcagcttct tcaatatcaa 2664181 aaatctgcat aaacaacgcg agcttttctt cagaatcagc atctgccgca agctctttca 2664241 cctttaaaat cggatcacga agcatttggt taataatact tttggtgtgt ttgttcaaca 2664301 gttttttctc tcttgtgctt aagtgaggca gcttacgctc aatgctgtcc atcgtttctg 2664361 actggatggc aagcgccttt tcgcgcaatg cagaaataac aggcacaaca ccaagtgtat 2664421 tcatccattg tttaaattcc acaatggttt cttcaattaa cagttcaact ttttcagctg 2664481 tttctctccg ctctttcatg ttcgcttcta caatgccttc cagatcgtcg atatcataaa 2664541 gaaaaacacc ttcaagatca ttcagcgccg gatcaagatc tctaggcacg gcaatgtcga 2664601 ccataaacag cggacgtccc ttgcgaagct tattcgcgtt ttccatcatc tctttggaca 2664661 cgacaaattc acttgcaccg gttgaactga ttaaaatatc agcctccgca agcgcgcttt 2664721 caagctgatt caagcttctc gcttcacctg aaaaacggtc tgcaagctcc ttcgctttca 2664781 agtatgttcg gttaatgaca gtgaccttgc cgattccctg tccgtgcagg ttttccgcag 2664841 caagctcgcc catttttccc gcaccgagaa tcaatatgtg cttgcttgaa agatttccga 2664901 agattttttt ggcaagttca actgcagcat agcttactga caccgcattt gagccaatgt 2664961 ctgtttcggc gtgagtccgt ttgcccactg taactgcctg cttaaacagc tcattaaaaa 2665021 tagtcccgat cgttttttct tgctgagctg ttttaaagct gtcgcgtacc tgtccgagaa 2665081 tctgcgtttc gccaatcacc atagaatcaa gtccgcaggc tacacggaat aaatgctcaa 2665141 cagcggcatc gctctcataa aacgttaaga acggtgacag ctcttctttg cttaattgaa 2665201 accaatcagc taaaaacttt tttatataat aacggccggt atgaagctgg tcgactaccg 2665261 cataaatttc agtgcggttg caggttgaga caatgatgtt ttcaagaatg cttttctctt 2665321 ctttcagctg caccattgct tctgccagct cattcggctg aaaacttact ttttcacgta 2665381 tctcaatagg ggcggattta taatctactc ccacaacaag tatatgcatc gctctaatta 2665441 cacccccaac acccaatctt aatttataat cattctaaca tagaactcat tatttataat 2665501 aattataaca tagtttcttt cacaaaatgt gaacagattt taaaattctt atgctatatt 2665561 agaaaaagct tcagggaaaa gaagcattcc tattgacaat accaaaaaca gcagaaattt 2665621 actacacatc agctctaaaa aacaagaagg tgatatgcat gaaacaaaaa tcaattttat 2665681 tcccttgtct gctgcttgcc gcttctgtat atgcatggct agaaagcggc caagccgaac 2665741 tgttttcagg gcaggatcaa tggcctgttc tcctcatgct gttaggcgca gcctttgtat 2665801 atcaaggaaa aaaagaagcc gtcacacccc atttttttat cggtttgctt ctcttcggga 2665861 tcggtttaca cttttttgcc aagccgaaat gggtatggtg gccggatgat tttgaaatgc 2665921 tcctctttat gatcggcttc tcacttctcg tttcaaccgt tcaaaaaaaa gaatatgtat 2665981 atgaagctgt gtcgatgatt tgtttttccc tgtttttgta ctttttcaaa caaattatgg 2666041 catggcttga gtctgcgcat attccaacag cgcttctgaa ggagtattgg ccgtttgtct 2666101 ttattggaat cagtttattg ttattattga taaaacgaaa aaaatctata cgataaataa 2666161 aaccggtaga ggatcctcta ccggtttatc atttttttga tcgctcccca agcttcgtct 2666221 tttccctttt tcgtttctga agaaaagagg atcagctcgt cttccggatc aatatttaat 2666281 gtttgtcgga caaccttcgc gtgtttgtcc catttacctt tcgggatctt atccgccttt 2666341 gtagcgataa caataacagg aatgccgtaa tactttaaaa attcatacat ctgtacatca 2666401 tcattagatg gcgcatgccg caaatcaacg atctgcacca cagcttttaa ttcctcgcgt 2666461 gtcgtgatat aggtttcaat cattctgccc catgcttcac gctcagactt tgacactttg 2666521 gcaaaaccgt agcccggcac atccacaaaa tgcagctcat cattgataat gtagaaatta 2666581 agcgtttgtg tttttcccgg ctttgatgac gttctcgcaa gatttttgcg attgattaat 2666641 gaattgataa aagacgattt tcctacgttc gatcttccgg ccaatgcgat ttccggaagc 2666701 cccccttcag ggtactgttc cggttttact gcactgatca cgatttctga ctttgtgact 2666761 ttcatttctt ctctcctact aaggcatgtt ccaaaacctc gtctaagtgg gacgccaata 2666821 taaatgtcag cccctccctg acgctttccg gaatatcctc tatatctttt tcattatctt 2666881 taggcgcaat aatggtcgtt aatcccgctc tatgtgcgcc aagcgctttt tcctttaagc 2666941 cgccgatcgg cagcacgcgc ccgcgaagcg tgatttcccc agtcatgccg acttcacgcg 2667001 aaaccgcccg tcccgttaaa gcagaaacaa gcgctgttgc catcgtaata ccggctgacg 2667061 gaccatcttt tggcaccgca ccctctggta catgtatatg aatatcatac ttctcatgaa 2667121 agtcaggttc aatgccaagt tcttctgttt tggatcgcac atagctgaat gcagcctgag 2667181 cagactctct cataacatct ccgagctttc ctgtcaggat taatttccct tttcccggtg 2667241 aaagcgatac ttcaatcgaa agcgtatctc cgccaacggt tgtatacgca agccctgtca 2667301 ctacaccaac ttgatcctct gtttcagctt gtccatatct gaaaatgcgt tttccgataa 2667361 aatcttgaag gttcttctca gtaaccgtaa ttcgttttcg ctcttcagca acaatggctt 2667421 ttgcagcttt acggcaaatt gcggcaagct ggcgttcaag gcttcttaca cccgcttctc 2667481 tcgtatagta acgaataata tcaagaatcg cctgatcacg cagctgaaga ttgcttttct 2667541 tcagcccgtg ttctttgatt tgctttggaa gcaagtgatc ctttacaatt tcaagttttt 2667601 ctatttctgt gtagcctgcg atattaataa tttccattct gtctctgagc gggcccggga 2667661 ttgtggccaa attgttcgcc gttgcgataa acagcacttt ggataaatca aaggtttctt 2667721 caatatagtg atcactgaag ctgctgtttt gctctggatc aagcacttca agcatagcgg 2667781 atgatgggtc tcctctaaaa tcagatgaca ttttgtcaat ttcgtctaat aagaagaccg 2667841 gattcagctt gcccgctttt ttcatccctt gaataatacg tccaggcatt gctccgacat 2667901 aggtccgtct gtgtccgcgt atctctgatt catcccgaac tcctccgagt gagattctga 2667961 cgaatttgcg tcccaagctt tttgcaattg atttggctaa agacgttttt ccgacacctg 2668021 gaggtcctgc caaacagaga atcgggcctt tcagggattt tgtcagcttc tggacagcca 2668081 aatattctaa aatacgttct tttacttttt caagcccgtg gtgctcttcg tccaagagac 2668141 gtcctgcttc tttcaaatca agcttatcat ctgtttcatc cgtccacgga agagcaacca 2668201 gccagtcgat atagttgcgg atcacagagc tttccgcaga acttgacgga attttttcat 2668261 atctgttcaa ttctttaagc gctgtttctt tcacatgatc aggcatgcct gcttcttcga 2668321 ttttttccgt cagcgtctga acttcgccag ttttgccttc tttatcgcca agctcttttt 2668381 ggatcgcctt catttgttca cgcaagtagt attccttctg cgtacgctcc atcgaacgtt 2668441 tgacgcgctg gccgattttt ttctcaatct ccagcacttc tttttcatta ttaataaaat 2668501 caatgacctt gttcagcctg tctttgacat cagccgtttc taaaatatcc tgcttatcct 2668561 ttagtttaag gggcagatga gaagcaacga tgtctgccat tctccccggc tcttcgatat 2668621 cagtaaccgc agcgtacgtt tcggccgaga tttttttaga aatttttatg tactgatcaa 2668681 agtggtctag caaagtccgc atcaatgctt cgtcttctgt atcttttgaa tcatcttcat 2668741 gaataagttg aatgtcaacc gacgtgtaat cctcgtgttc attgtatttg acgatatggg 2668801 cgcgcttgag gccctccacc aacacacgaa tcgtaccgtt cggaagcttc agcatttgct 2668861 taatttttgt ataggtgccg acagtgaaaa tctcgtcttc accaggttcg tctatcgaaa 2668921 tatcctgctg agtggctaaa aatatcatat gatcatgcat cattgcctgt tcaagagcct 2668981 gaaccgactt gtcacgtcct acatctaaat gcaaaaccat cgtcgggtac actaataaac 2669041 ctcttaaagg gaggagcggg atgctgcgtt ttaattcttc tgccatgtga ctgacacctc 2669101 cgtgacttta gtatgaacca ttataataca actttttcat ccttgtacaa taaacggcat 2669161 ggttccattt tctataaaac agtctcctcg tagtataccc tttctttctg atatgaaaaa 2669221 ggaaaagatg tccttcatga aaaaaaccct attatcaaaa tagggtttaa acggattctt 2669281 tattgatttc gatatgaaac ggtttttgtt ccgttggcgg attcaccaaa atttcatcaa 2669341 gcacttcttg gaacgtcttc actgcaataa tctcgatccc gtcaatctgc tttaagatgg 2669401 cctgctgatt ttcatatggg ataatcacct ttttcgcacc ggactgcttg gccgctttta 2669461 ttttcggaat gacgcctccg atgggtttca caagaccgtt caggctgatt tcgcccgtca 2669521 tcgcaacggt attgtcaata ggaattttgt gtatcgccga gaaaatcccc gccgccatcg 2669581 caatgcctgc tgacggccca tcaatcggaa tccctcctgg gaaattgatg tgaatatcat 2669641 aatcagaagg cttcattccc attgtccgga gcacggttaa tacattttca accgaaccct 2669701 tcgccatgct ttttcgcctg atcgattttg attggctgcc gatgctttct tcttcagcta 2669761 ttcctgtgat gttaattgat cctttatctt gagccgcggt tacacttact tcgatttcca 2669821 gaagcgatcc gctgttaggc ccatagactg caagcccatt tacaatgcca acctgtggtt 2669881 caacaccgat tttttgctcg tgctttggag taagctgact ggagtgaatg acccattcaa 2669941 tatcctcaat cgtaatgtcc tttcgattct ccgttacagc catccccgct gcgatttgaa 2670001 tcatattgac ggcttcccgc ccgttccgcg tgtagctggt caaaagatcc agtccttctt 2670061 cggagatatt tttttcaatt ttatccgctg ctgttttggc aaccgttttc agctcgtcct 2670121 tttcaagctc gcggaaaaaa acctccaaac agcgggaccg gatagctggc ggaatttcgt 2670181 ttggcattct cgtggtcgcg ccaatcaagc gaaaatcagc cggcagccca ttttgaaaaa 2670241 tatcatgaat atgattcgga atttgtgtat tttcctcact gtaatacgca ctgtctaaaa 2670301 agacttttct gtcctcaagc accttcagca ttttattcat ttgaatagga tgcagctccc 2670361 ctatttcatc aataaacagc acaccgccat gggcatgggt gacagctccc tgcttcggct 2670421 gcggaatccc agcctgtccc atcgctccgg ccccttggta tatcgggtca tggacagagc 2670481 cgatgagcgg atcggcaatt cctctttcat caaaacgggc tgttgtcgca tcgagttcca 2670541 caaagacagc ctgctcttta aacggtgatt gtttatgttt ttttgcttct tccaacacaa 2670601 gccgcgcagc agccgttttc ccaactcccg gtggcccata gacaatcaca tgctgaggat 2670661 ttggcccgca taaagccgcc tttaatgctt taatgccgtc ttcctgtccg acgatatctt 2670721 taaagctttt ggggcggacc ttctcagata atggctcgga caagctgata gcgcgcattt 2670781 tccgaagctg ctccatttcc ttctttgatt ctttatctat cgtgaccttt tgtgtccttt 2670841 gatttttaag caaattccaa aaatacaaac cgatgatgat cccaaaaaac agctgaataa 2670901 ataacgcgat ccctgtccaa ctcatggtgg tccctcctga aaaacaattt atgtatccaa 2670961 ttcattcctc tgattgctag tatctcccat agaagacggg aataaacgtt tttccggaag 2671021 agttgcatgc aaaaaaacct cctgagtgtt accactcagg aggtttgtgc ttatctttat 2671081 gcagatgttt tatcttggct tacctcagtg ccgtctttta ataagaggcg aggaggctct 2671141 ccgtgtgtca cagttgcccc ggtgattaca catttttcaa tgtcatcacg agaaggcagc 2671201 tcaaacatca catcaagcat gatgccttca atgatagaac ggagtccgcg tgctccagtc 2671261 ttgcgttcaa ttgctttttt agcaatttca gaaagcgctt cttcttcaaa ctcaagctca 2671321 acgttgtcaa gctcaagcat tttcttgaat tgcttaacaa gagcgttttt cggttttgtt 2671381 aagatcgcaa ccaatgcttc ttcgtcaagc ttttcaaggc ttgcaataac cggaagacgt 2671441 ccgataaatt caggaattaa cccgaaacgg agcaaatctt ctggaagcac ttttgaaaga 2671501 agatcttctt tctcaagatc agcagcttta ttgtcggcac cgaatccaat cactttttgg 2671561 cctaaacggc gtttgatgat ttgttcgata ccatcgaaag ctccgccgca aatgaacaaa 2671621 atatttgttg tgtcaatttg aatgaattct tgatgaggat gcttacgtcc accttgaggc 2671681 ggtacgcttg ccactgtacc ctcaagaatt ttaagcaatg cctgctgtac accctcacct 2671741 gacacatcac gtgtgataga cgggttttca gattttctag ccactttatc gatttcatca 2671801 atatagataa tgcctttttc ggctttttcc acatcataat cagcagcttg gatgagcttc 2671861 aagagaatat tctctacatc ttcacccacg tatccagctt cagtcaaaga tgtagcgtcc 2671921 gcaatcgcaa acggcacatt taaaatgcga gccaatgttt gcgccagaag ggttttaccg 2671981 cttcccgtag ggccgattaa tgaaatatta ctttttgaaa gctcaacatc atcaactttg 2672041 ctgttggagt taatgcgctt atagtggtta tacacagcaa cagcaagtga tttcttcgct 2672101 tgatcttggc cgatgacata ttcattcaaa atttcgcgaa tttcctgagg ctttggtacg 2672161 tctttaaatt ctacttcttc ttctgttccg agttcttcct ctacaatttc agtgcagagt 2672221 tcgatacatt cgtcacatat atatacacca ggtccagcta caagcttacg aacctgatct 2672281 tgtgtttttc cacagaacga gcattttaat tgtccttttt cctcgttaaa tttaaacatt 2672341 ctttcacccc ttaatcttgt ctcacttttt cttttaccgg cagagcaaaa gaaaatgatt 2672401 cttgaaacga acgagtatgt attgcatttt accatacttt ccaaaaagac ggtaacaatg 2672461 tgtttctgac ttgcacattc tatatgtatg acaaaaaaca gccctgcatt aactatattg 2672521 ccccaagaaa aagagataac tcataattgt acaaaacaag gcacgaatga ttcgcgccct 2672581 gttttattag tactattatt atgcaccata ttaacggttt tctacaagaa aatcaattgc 2672641 tttgcgaact tttaaatctt ctttcatcgc gtcagtagaa ccgatggctt gtttaatatt 2672701 ttcaacaggc atgttgtatg cttcagccat ttttgtaagc tcagcatcaa cttcctcatc 2672761 tgatacttca aggttttccg ctttcgcaat cgcctcaaga gtcaggttag attttacgcg 2672821 tttttcagca tcttctttca tttgctcttt aagcgcagct tcatcttggc ctgagaattg 2672881 agtgtaaagc tcaaggttca tgccttgcat ttgcagacgc tgttcgaatt ctttcagcat 2672941 gcggtcaagc tcagtgtcga ccattgcttg aggcacatcg atttcagcat tttcagaagc 2673001 tttcagaaca agctcttcac gcaatttagc gtcagcttcg ttttcttttg cttcttctaa 2673061 acgtttcttt gttttttcag ttaattcagc aagtgtttcc acttcttcat cgatatcttt 2673121 tgcgaattca tcgtcaagct caggaagctc tttcgctttg atttcgtgaa ttttcacttt 2673181 aaacacagct ggtttgcctg caagatcttc agcgtggtac tcctcaggga atgtcacttc 2673241 aacatccttc tcagcacctg cttcaaggcc aactaattga tcttcgaagc cagggatgaa 2673301 tgaaccagaa cctacttcta gagagtagtt ttcagctttt ccgccttcga aagcttcgcc 2673361 gtcaacgaat ccttcgaaat caagaacaac tgtgtttcct tcttcaacgg cgccttcttc 2673421 ttttacaaca agctcagctt gacgctcttg aagggctttt agttcgtttt gaacatcttc 2673481 gtcagttaca gttgtgtcgt ctttttcaat gcccaggcct ttgtattcgc caagcttcac 2673541 ttcaggtttt actgttactt tcgcagtgaa gattaagctt tcgccttttt cgattttttc 2673601 aacatcgatt tcaggacggt ctacaggctc gattccagct tcttcaaccg ctttagggta 2673661 ttctacagga agaagaatat ccaaagcatc ttggtaaaga gcttctacgc caaagcgctg 2673721 ttcgaataat ccgcgaggaa ttttaccttt acggaatcca ggaattgaaa cttgttttac 2673781 tactttttta aatgcatcat caagtgctgt tttaaacgtt tcagcatcaa cttcaaccgt 2673841 taaaacgcct tcgttgcctt cttgtttttc ccattttaca gacatgtgtt tccctccaaa 2673901 aatctattca ggttgtgtcg gtcttccatt ctaaagcaat cattcggctt cgtccaacaa 2673961 aaacaaagct gccaaagatc agaatcatta tgtatagatg ttaataatga actgcaaagc 2674021 ctgtccaacc gtatttctta taacccgtta tacacaaata caaccactat attataacat 2674081 aacacatagc gctttcaact atatggcgcg atttacaaat aagaaatttc ttcaatatct 2674141 tttaacattg tgcaagcttc atcgagttct ctgtctgtaa attcatacat catatgaagt 2674201 tcttcgcttt caatttcaat cccgtgcatc tcgtaaccga ctttatgaag ggcagccgcc 2674261 caaaggtcag ccgacagcaa tttcggctgg aacggatata aaacgtacaa atgtcttctc 2674321 cacaattctt ctactgctgc atataaggtt ggattttcat ttccaagtgt ctcatctagc 2674381 accctgagaa cacggtgaag aatcggcgcg gcatcaggcg gaacaatctc tgacggttca 2674441 attgtcaacg actcgccaaa tttactaatg tgtacaggtt tactgtactc atgctcagcc 2674501 aacagcatga caatcatcgt tttgataatc ggatgggctg aggggtcttg gaggattgtt 2674561 ttgagcaatc ctgtatactt tgctacgtta cggtctttta aggaatgaat gagattcatt 2674621 tgctcctcag ggcttgccag cactttctcg gtgtcaattg tatcctcata ttcttcggcc 2674681 caagcctcgt cctcacgatc cggatcggtc attttccggc tgaaatccag cagcttataa 2674741 aattgctcgg cactttctgc cggcagctga ttttcttcca aaacggcttc aatggtgctt 2674801 ttgacttctt cgtacttttt gagctgaatt aagatggtca tgtacacctg caaaaccgta 2674861 aaataatggc cataaccttc tttgagcatc ttctcgcaca cgctttctgc ctcttccagc 2674921 tcgcccagct ctaaaaagca gatggccatc cctaagtgaa gatcggattc agtatcatca 2674981 tatttcatcg cttctgaaaa cagttcaagc gcttcttgat actttttttc cttgagtgat 2675041 gacatccctt tttccacaag gcggtctttc agatgaggaa aaggaataat ttttgcgttt 2675101 ttcttgtcat gcgtcatacc tatattcctt tcaggcattt attttgttca agtgtatcaa 2675161 cacctgtgaa caaaaacaag aaatgaaagg tttcaccagg caaaaaaagc cgccggacaa 2675221 ataccggccg ctttttcagg cttgaagcca agagcttctt tgtgattcaa attgcttgat 2675281 ttcatcttcc agcagcagcg ttaatgaaat ttcatcatat ccgttgatca gcatctcttt 2675341 ccaatgcgga tcaacttcaa atgaaatttg attgccttca ctgtcatgaa tcagctgatt 2675401 ttcaaggtca acagtcattt gcaatgactg gttttcatac tggccgacaa gctgtttcca 2675461 attgtcatat ggcatgcgga tcggaagcat gccgttttta aagcagttct gatggaaaat 2675521 atcagcgaat gacggcgcaa tgataatttt aaacccataa tcatcaagtg cccacggagc 2675581 gtgttcacgc gatgacccgc agccgaagtt ttctcctgct attaaaatgg aagctccttg 2675641 ataaacaggc tggtttaatt caaattcagg gttcggttca ccattcgcat catatctcca 2675701 gtcaaagaat gcaaaacgtc cgtagcctgt tctttcaatc ctcttcaaaa attgcttagg 2675761 aataatctgg tctgtatcca cattgatccg atttaatacg gctgctttcc ccgtatgtga 2675821 tttcaaaggt tccatctcgc gcactcctta cacaactgtt ttttcctgat aaaactttct 2675881 gacatcaacg aagtgtccgt gaatggcagc catcgcagcc attgccgggc tgacgagatg 2675941 tgttcttgca ccttttcctt gtctgccctc gaagttgcgg ttagaggttg atgcacagcg 2676001 ctctccctca ggaacaacat cattattcat actcaaacac atgctgcagc ctgactctct 2676061 ccattcaaat ccagcttcca agaaaatctg gtcaagccct tctttttcag cctgaagctt 2676121 cacgctttgg gatccgggca cgacgatggc ccttacgctg tcagctacct tcttcccttt 2676181 gatcatgtca gcagcctgtc gaaggtcagt catgcgggaa tttgtgcagg aaccgataaa 2676241 tacgtgctcc actttaatgt cttcaatttt ttggtgagga gtcaatccca tatattcata 2676301 agcacgaatc gcttcttttt tatcgtcttc tgcagaaaag ctttccggcg caggaacttc 2676361 agaatcgaca ggaagaacca ttcccgggtt aatgccccat gtcaccatag gggaaatttt 2676421 gttgccgtca aggacgatag atttatcgta aacagcgccc gggtctgtgc gcagcgcctt 2676481 ccattcctct acggccttgt caaattcttc gccttttggc gtgtacttgc gatttttgca 2676541 atattcaaac gtcacctcgt caggtgcaat caaacctgct cttgctcctg cttcaattga 2676601 catgttacaa acagtcattc gttcatccat cgtcatattt ctgaatactt ccccagtgta 2676661 ttcaatgacg tagcctgtgc cgaatttcac accgtatttg ccgatgacag caaggatgac 2676721 atcctttgcc gttacccctt tttgaagcgt tccatctacg cgcacttcaa gtgtttttgg 2676781 acgctgctgc caaagtgtct gtgtggaaag gacatgttca acttcactcg tcccgattcc 2676841 aaatgcaaga gcgccgaaag cgccatgtgt tgatgtatga ctgtcaccgc acacaatcgt 2676901 tttccctgga agcgttaagc ctagttcagg tccgacgaca tggacaatcc cttgatccac 2676961 actgtgaaga tcggcaaggc gcacgccaaa ttcctcacag tttctttcaa gcgccgttac 2677021 ctggcgtttc gcaacttcat cctttatctc aaaacgattg acagtcggga tgttgtggtc 2677081 cattgtcgca aatgtgtttt ggggtcttct gacctttctt cccttttgtc tcaagccttc 2677141 aaatgcctga ggagacgtca cctcatgaat gaggtgcaaa tcaatataga gaagatccgg 2677201 ctttccctca ccatgtttta caatatgctg atcccaaatc ttttcgatga ttgttcgagg 2677261 catcatcttt tatttcctcc ctctacctag agctaagacc gcttaacgta agctgtcaca 2677321 cattagaaat tgtattttca ctcatgattg ctgccttaac ttcctctgta atggcctgag 2677381 tgctgctgaa ctcttcactc cgtgccaagt ctcttgttct ttttccagaa gccaagactt 2677441 tgtttaccgc atcttctaca gctttcgctt cctcttcaag cccgaaagat gttctcaaaa 2677501 gcattgccgc tgacaatatg gctgcgaacg gatttgccat ccctttaccg gcaatatcag 2677561 gcgcggagcc atgaacaggt tcaaacagat gaaggccaga gcttgatagg ctggctgacg 2677621 ggagcattcc gagcgagcct gtaagcatgg acgcttcatc gcttaaaata tcaccgaaca 2677681 tattttcagt caccacgaca tcaaattgat tcggtgcata aattagctgc atggccgcgt 2677741 tatccacaag catgtgctca agcttcacat caggaaattc ttgtgcaacg tcctcagcca 2677801 cttcacgcca cagccggctt gattcaagaa cattcgcttt atctacagag gtcactttgc 2677861 cttttctggc tgccgccatt ttgaagccct ctctgatcac tcgttcaatt tccgttcgct 2677921 tataaaacag tgtatctact gcttcctgct caccttcagt gtttacataa cgtttgctcg 2677981 gctggccgaa atacaagccg cctgtgagct cacgaacgat aacgaaatca acattatcta 2678041 tatattcttt tttcaaaggc gaagcgtcag aaaggctttc aaataccttc acaggccgca 2678101 aattcgcaaa caaatcaagc tgttttctga tgctgagcag ccctttttcc ggtctcagtt 2678161 ccgaaggatt ttgatcccat ttcggtccgc cgacagcacc aagcaatatc gcgtctgcat 2678221 ttttacaagc agcaacggtt tcctccggga gggggttatg atgttcatca atagccgccc 2678281 ctccaatcag gccatattca aattcaaatt catggttaaa gcgttcggca acacttttca 2678341 gtacgtctgt cgctgattct aatacttcag ggccgatccc gtctccgggc aatagagcaa 2678401 tacgtttctt caagttaacc gttctccttt cttttatgat ccgacagctg tgtggttttt 2678461 caatccgctc atattcgact ggaaaaccaa ttgacggttt actgcgttca aataggcttt 2678521 cgctgatgct tctaatacgt cttgcgctat gccccgccct gctgattctt ttccgttcac 2678581 caaaactctt acatacacct gggcaaatgc atcttcgcct tttctattag actgaatgcg 2678641 gtagtctaag agctccacat ccttatcgat gcagcgctca agcgtattgt agattgcttc 2678701 cacgcttcca gctccagttg cagcttcctg aataagctgt gcgttttctt gatttttcaa 2678761 agatagagta gccgtaggga cctgacttgt tccgtaatgt acttgcagag aaagaaattc 2678821 atacccaatc ttgcgatctg ttactttttc ttctaaaata agagaaacaa gatcctcatc 2678881 agtgatttct tttttcttct cagtcaactc tttgaacatc gtaaagaatt tattaatctc 2678941 ttcactgtca aattggaatc ctaaagcagt cagccggtct ttaaatgcgt ggcgtccgga 2679001 atgtttacct aggacaagcg catctgcggt tacgccgaca agctccggtg aaataatttc 2679061 ataagtcgat ttttccttta aaaagccgtc ctgatggatg cctgattcat gagcaaatgc 2679121 attatctcca acaaccgctt tgttgcgcgg gacagccatg cctgtcagtt tgcttactaa 2679181 atcacttgtt ctcttaatct cgttcagcgt aatacctgtt tcgacttggt agaaatcttt 2679241 tctggtatgg agggctacgg caatttcctc taatgccgcg tttccggctc tttcaccgat 2679301 cccgttcaca gcgcattcga tttgatcagc gccattttca atcgcagcaa gagagtttgc 2679361 gactgccatt cccaaatcat catgacagtg ggctgaaagc tttgctttgt gaatgttcgg 2679421 aacgttttct ttcatatatt taaagatatt tccgtattcc gccggggcca ggtagccgac 2679481 agtgtccgga agattgataa cactggcgcc tgcgtcaatc actttctcga cgatttctgc 2679541 tagaaacggc agttcagtgc ggcaggcatc ttcagctgac cattgcacaa tcggaaaacg 2679601 ttcttttgcg tatttcacca ttccaactgc tctttcaatg acttgttcac gtgtcatttt 2679661 cagcttgtgc ttcaaatgaa tgtccgatgt cgcgataaat acatgaattc ttggttgagc 2679721 gccatccttt aacgcttccc aagcagcatc aatatcacct tttacacaac gggccagacc 2679781 agttactgaa caatttttaa tggttcttgc gatttcctga acagctaaaa agtcacctcg 2679841 ggacgaagcg ggaaatcccg cttcaatgat gtctgccccg agtctttcga gctgcttagc 2679901 tatggcaagt ttctcctgtg tattcaagtt cactccaggg gactgttcac catcacgaag 2679961 cgtcgtatcg aaaaaattaa ttttgcgcaa cggagaccac cgcttccttc ttcttgcctt 2680021 gtttcacaaa cggcatcatt tcacgaagct ttcttcccac tacttcgatt tgatgttcgt 2680081 tctcgcttgc attgatagcg ttgaaacgag gacggtttac ttggttttcg acgatccact 2680141 cttttgcgaa tgtaccgttt tggatatctt ttaatacttc tttcatagat tcttttactt 2680201 tggcgtccac aacgcgaggg cctgatacga aatctcccca ctgtgctgtg tcagagattg 2680261 aatatctcat tcctgcaagt ccttcttcgt acataaggtc tacgattaat ttcagctcat 2680321 gaagacactc gaagtatgca agttcaggct gataacctgc ttcagttaag gtttcaaatc 2680381 cggctttgac aagcgcgctt aatccgccgc aaagaactgc ttgctcaccg aacaaatctg 2680441 tttctgtttc ttctttaaat gtcgtttcta atacgcccgc tcttgcgccg ccgattcctt 2680501 tagcataagc gagggctttg tctcttgctt ctccagtcac atcttgatag attgcgaaca 2680561 atgcaggtac gccagctcct tgctcatatg ttcttcttac caagtgtccc gggcctttag 2680621 gggccactaa gaatacatct acatccgccg gaggaacaat ttgatggaaa tgcacgttaa 2680681 atccatgagc gaatactaat gattttcctg ctgtcaattc atctttgatt tcagcttcgt 2680741 atactttttg ctgctgctca tccggaagca gaaccatgat gatttcggct tgggctgccg 2680801 cttcttttac tgaaaatact ttatgtccgt cttcttgggc ttgagtgaaa gattttcctt 2680861 gtctaacacc gacgatcacg tctactccgc tttctttaag gttcagggca tgtgcgtggc 2680921 cttgcgaacc gtacccgata accgctactg tttttccagc caatacgttc tctttgatat 2680981 caccgttata atatactttt accatttcaa tctctccctt gttatgtttt atacaataga 2681041 tattgtttta ttggatgacg ccttttgctg ggttcccctc gcaaaagccg ttgtacctgt 2681101 tctcgcgatt tctttaatgc cataaggttt taataactca ataagcgctt caattttgtt 2681161 agattcacct gtcacctgaa caacgatgct gtctctgctg acatcaacga cagaggctct 2681221 aaacggttct atgattccat taatctctgt tcttgttgaa ggtgcggaga caaccttgat 2681281 taaggccagc tccctctgga caatcgattg atttgtgatg tctgtgactt tcagcacatc 2681341 aatctgtttg ttgagctgtt tcgttaactg ttcaacatca ttttcacctt caacatgaac 2681401 gacgaaggtg attctggaaa cgccggctgt ttctgtgtgt ccaactgtaa tgctttcaat 2681461 gttgtaatgc ctttttgtga atagaccggt gatccggttt aacaccccgg agcggttcac 2681521 cacagtcaat gtgataattc ttttcaaggt ttcaccccca ccatttcatg cagccctttc 2681581 cccggagcca ccatcgggaa tactttttct tcgctggcaa cccgcacgtc aatgacaaca 2681641 ggttctcttg atgttaatgc ctcttccagc ttttcctttg cttccgcttc tgatgaaatt 2681701 ctgatgcctt taatgccgta tgcttcggac aatttgacga agtcaggctg agaagcgaat 2681761 ttagattctg aataacgttc ttcatagaaa atttcctgcc actgtctgac cattccgaga 2681821 caagcgttat ttaaaatcac taccttgacc ggaagattta attcgcgaat aacatcgagt 2681881 tcttgaagcg tcatttggaa tccgccgtct ccgacaaccg cgacaacagt agcatctttt 2681941 tcggccagct gtgcgccgat cgccgccgga agaccgaatc ccatcgttcc aagtccgcct 2682001 gacgtgaccc atttatctgc tttttggaac ggataaaatt gcgctgacca catttgatgc 2682061 tggcctacat ccgttgcgac aatggcctct ccttttgtaa attgatgaat atattcaatc 2682121 aatttctgag gtttaaaacc ttcttcttca ttatctacat accagagcgg atactcttct 2682181 ttccattctg cgagctgttt tttccattcg cttgaatcgc tttgtttgcc gtcttgtttg 2682241 atcagctcct gcaggacaat tttgctgtct ccgactacag gaatctgtgt tttcatgatt 2682301 tttccgattt cagctggatc aatatcgatg tgggctatct ttgcgtttct ggcaaagtgt 2682361 ttcaggtttc ctgtgacacg gtcatcaaaa cgggcgccga tactgattaa tagatcacat 2682421 tcatgaaggg ccatattggc tgtataagta ccgtgcattc ccgccatccc taggaaaagc 2682481 ggatggtcag ccgggaagcc tccgagcccc aaaagggtgt gtgccacagg gatttgctgc 2682541 tgttcagcat aattttttaa ttcttctgac gcttttccgt gcagtacgcc cgcacccgcc 2682601 aggatcaccg gttttttcgc actgctcacg gcttccacaa gcttgcggat ctgcaaataa 2682661 ttcggctctg ttgtcggctg gtatcccggg agattcatct catgatcgta gctgaattct 2682721 ccttcaattg ttgctacatc tttcggaata tcaatcaata caggtccggg tcttccagtt 2682781 gttgcaatat ggaacgcttc tttaatgatg cgcggcagat cttccggctg gcgaacctgg 2682841 tagctgtgtt ttgttactgg catcgtaatc cctaaaatgt ctgcttcctg aaatgcatcg 2682901 ctcccgatta cagaggttgc tacctgccct gtaaagacga ctaacggcaa tgaatcaatc 2682961 atggcatcag caaggcctgt aacaaggttt gtcgctcccg gccctgacgt ggcaatgacg 2683021 acacccggtt ttccggagac ccttgcgtat ccctccgctg catgaattgc tccttgttcg 2683081 tgacggggaa ggatatgtac caaccctgaa ttgtatagct tatcgtaaat cggaagcaca 2683141 gccccgcccg gataaccgaa gatcatttct actttctctt tttttaatga ttcaatcagc 2683201 attaatgctc cgctcatcgt ctgtgtacat tcggcagatg ctgaatccac ctgtacatta 2683261 gtccccattt tagttcctcc ttttggattt tcatccttta aagatcatct tttcattagc 2683321 tagatagctg attattcaat aaaaaaagcc cttccgccca caatcagccg cgcagtaact 2683381 gcgatagcta aaaggggcga aaaggctttt ctttccgcgg taccaccctt gtttacggcc 2683441 tgttaatcgg ccgtctcatg gatatttcta tccgctttag taacgagtga atcaagttca 2683501 cccggccaag tcctactgtc atttcagact ggcactctga ggcgagttca ccttgtaaag 2683561 cttcgccggt tctcagctaa cccggttctc tgtggaaaac tttatcaagg ctacttatcc 2683621 tcatctgcgc ttttcatatt cagccttcgg aacggctttc cagctgttca agaaggtcgt 2683681 ttgtttttca tttttttaga atcatactgc gatgattttc gcttgtgaag cttgcattta 2683741 tcttttgttg aactcatatt acgccgcttt ggacgcagtg tcaacagcat tttttaaaat 2683801 tattagacaa ttttgattaa tcaatctata ttgtatacgc tttcattatt ggtacaaaag 2683861 gaattgcaaa tgttaaaagt ttttataatt tttttattaa tctatcaaga atacaccaga 2683921 attatttaat tttatataaa catggaagat tttataacac gatatggttc gtatatggat 2683981 tgagtctgac agatcatctt gcaatccatt tcaatttcgg ataggcactt ctcttgttcc 2684041 ctcggcatac attaatgata tcttgcaaag aaaaggtgat acgatgaata aatcatttgc 2684101 agacatgcaa ggatttcctg cgggctttcc aagcttcccc aactttccgc agcagtacta 2684161 tcctgctgtc cctccctttt accagcaaag ccagcagcca tttggaggct acggatacgg 2684221 acagccgttc agtcaggcat acagcccgtt aaccactccc tctggaatgt actcctcatt 2684281 cccatacgct tcaggatttt acggacagca attttcaggt gcaggcttta gcggccatgg 2684341 cggcagctta agtgctccag cgatacatgc cggcggattc agcggggcgc caggcgtaca 2684401 cggaggcttt agatattaaa gaataccaca agggccgaac atctattgcg gtccttttat 2684461 tgttttaaaa cgacttcaca agtacagtca cattttctgt ctttatattt ggaaacagga 2684521 tggaatatga ttaagatgaa ttgaacgata ttctgcacaa tccgtaagtt ttcgaggagg 2684581 aataaaattg catataaaaa tagacgattt aactggacgt caggtggttt cactggtgaa 2684641 tgagcattta catagcatga cgcttatgtc cccgccagaa agcattcatg ccttaggtct 2684701 agaaaaacta agagggcctg aaataacatt ttggagcgca tgggaaggtg atgaactagc 2684761 tggctgcgga gcgctaaaag aactggacac ccggcatgga gaaatcaaat caatgcgaac 2684821 atctgcatca catttaagaa aaggcgttgc caaacaagtt ctccagcaca tcattgaaga 2684881 agccgagaag cgaggctatg agcggttaag cttagaaacg ggttcaatgg cttcatttga 2684941 gccggcaaga aaattgtatg aaagcttcgg tttccagtat tgtgaaccgt ttgcagacta 2685001 cggtgaagat ccaaacagtg tgtttatgac gaagaaattg tgagacggct ttataaggat 2685061 agataagtgc aggggaaggt ctgtcttatc tatctttttt tatattcaca catttttcac 2685121 ctttatgata cacgccaatg ttttcaattt tgtttaattc aaagaacagc gggaattaca 2685181 aacgacatga acgatatcat gcaaattcat aaaggaggag attgatatga aaagcatagt 2685241 tggtgtatat gaaactccgc aggaaaccat cgcagcgatt gaaggcttac ttacaaaagg 2685301 ctatgattct gatgacattt ctgttgtgac aagccggcga gatacagatt atttggagtc 2685361 acgtacagga acagaagtca atcaagctat cgatgcacat caggacgaat ctgaatcttt 2685421 tttcgataaa ctgaaagatt atttcacaat ggatgatact gctacacaca gcaaagcatt 2685481 atccgacttg gatattaaaa ctgatgaaat agacaagtat caagaagatt tggatgacgg 2685541 aaaacttctg gtagccgtcg atacagatgc agatgtaatt gctcctattg ataacggcaa 2685601 tgccctttca ggcggctttt caagcacaaa tgaattggat tatacaacga aagaagaaaa 2685661 aacgatgccg ctccgggaag aacagctgaa ggtcgataag gaagacgttc aaaccggcga 2685721 agtagaaata ggaaaagaag tgaaaacaga aaaaagagat atggacattc cggtgagaca 2685781 tgatgaaatt tatgtcgaac gccgtccagt ggatgaaaat aaaacggacg ctgctcccgt 2685841 caacgattcg gaagagatca gagttccaat cgttgaggaa aagctggaag tgactaaaaa 2685901 accggttgtc actgatgaag tggttgtcgg caaacgcact gttgaagaaa atgaacatat 2685961 ttctgaaact gtgaaaaaag aagaacctcg tctgaataaa gaaggaaaag ttgacggctt 2686021 ggatgatgat ccgttaaata acaaatgaaa atcatagacc gacaacaaaa aacctcaaat 2686081 cctaaatgga tttgaggttt ttcttttggt acgtcccagg agagattcga actcccgacc 2686141 gacggcttag aaggccgttg ctctatccag ctgagctact gggacacgtt ttgttttttt 2686201 gtttttcgct ttaactatca gcgacaagat ttattatata tgggatgcaa taataagtca 2686261 acggtttttt agaatttttt tcatgaggaa gaaaattttc ttcctcatga cattttcata 2686321 gtgtgactcg attttgcaga tcctcaattt cattgcctgc ttggtcgtaa aaacggactg 2686381 tcgcagcatc attttctaat gtcagtatag catagctttc tgtcctgcgc accctcggaa 2686441 gccggatgct gcctgggtta atcatcagtt ttccgcgcag cacttcgctt cccgcgatgt 2686501 gcgaatgccc gaagcagata acatccgccc cgagctcctc tgcacgatag tatacgttta 2686561 acaaggtctg ttttataccg tgaaggtggc cgtgtgtgac tagtattttt cttgagccgg 2686621 cagtcagaag aagctcgtcc ttaaaatcgc cggcaaaatc gcaattgcct tttacaaccg 2686681 cataaggctc caatgcagga tgcctcgtct caagctcaga gtccccgcaa tgaatcatga 2686741 gatcaacttc tgcctcatgc cgtttcgcaa tggtttggag ttcttcttca agcccatggc 2686801 tgtcactgat aatcagcacg ttcatgtaca agcttcctcc ttatgcctcc aaaagcttag 2686861 acagcttttt aagcgcgtca gccctatggc tgattttatt tttttcatca cttgtcagtt 2686921 cagccatcgt cttatcttta tctttcacga taaaaattgg gtcatagcca aagccatatt 2686981 ctcctctcgg ttcttcagca atataccctt caacatggcc ttcgactgtt tttgtttcct 2687041 ctccgggaat actcacggcc agtgcgcagc ggaaacgggc ggtgcgctgt tctttttcga 2687101 tacctttcag ctcgctgagc actttttcga tatttgcctg gtcgtctttc tgttcccctg 2687161 catagcgggc tgaataaacc ccgggtctgc cgccaagatt atcgatggat agtccggagt 2687221 catccgcaat caccattttg ttcactgctt tggcaacagc ttccgctttc ataatggcat 2687281 tttcttcaaa tgtatggcct gtttcttcaa tttcctctgt gaatccaatt tcagctaaag 2687341 atttgacatc atagcctctt ggctcaagaa tttctttgaa ttccttcact tttcccggat 2687401 tatgtgttgc aataattgct tctttcatga tgatcaagcc tttctgtctt tatttcagtt 2687461 ctggcagaga atcacccagc acttcttttt gcttgtcaat cagctcttgg attccttttt 2687521 ccgcaagacc cagaagaccg ttcagatcct ctctagaaaa agttgcctct tccccggttc 2687581 cctgcaattc cacaaaacgg ccgctgcctg tcatgatgac attcatgtca acttcagcag 2687641 aggaatcttc ttcataattt aaatctaaca aaattccctg ttccttatca attccaacag 2687701 agattgcagc aagaaaatca gtgatcggat ttgtcttgat tgttcctgct ttgatcagct 2687761 tgccaatcgc aatcgccata gcaagaaatg cgcctgtaat ggaagctgtt ctagttcctc 2687821 catcagcttg aatgacatca cagtcaatcc aaatcgtccg ttcaccgagc ttttccagat 2687881 ctacaacagc tcgaagcgcg cggccgatca ggcgttggat ctccattgtt ctgccggaaa 2687941 ttttcccctt agaagattct ctgattgttc tttggtttgt tgcccgcggc agcatgctgt 2688001 actctgctgt aatccagcct ttccctccgc cccgcaaaaa cggcggtacg cggtcctcaa 2688061 cagacgcgtt gcagattacc tttgtatttc ccgctgttat tagaacagaa ccttccggat 2688121 ggctgataaa atccaaatcg aatgtgattg gacgcagctc atcgtgttgt cttccgtcat 2688181 gtctcatgtt ttacctccga ttgtatgtac ataaaccatt tttgtcccgg aattgaataa 2688241 agaaagaggc agccggaacg ctaacctctt tcttcctagt atatcaaaaa tcccaattta 2688301 aaaactaccc gtattcactt gagatggtct ggagaccggt tctgtgagct tttcgccttt 2688361 ttcatttacc agctctgatt ttccgttcac tttaacagag acgcttttta catccggctg 2688421 ctccgttaac gtcagcacaa tgctgttcag cacttctgaa gaaatcattt tcgtcttctc 2688481 atcggcgctg ccgaatatag attgattgaa atccaacgtc acgcgcccgt ctttgatttt 2688541 cggtttgctg accagcttta catcttcact gaagtctgtt aacagcccgc tcaccttgct 2688601 cggcccttta gccaattcat taatggctgc tgtgatgtcg tctttttccg aattgtcgat 2688661 tcgtttggtc accggcacgt agtattcact gtcttcattt tccgccaaat agtagactgt 2688721 cagcggatgg gtagcagtga gatcatttac accggctgtt tccaaattaa tgccgtcttt 2688781 gcggcttaaa tcatctgaga tcggcgtccc tcctacaggc atctccttca gttcatgccc 2688841 gtttattctc agcttcactt tatctatcga actaaattgc gtcagcgtcc acgtcacaga 2688901 ttgaacgatt ttctgttcgt cttctttctt ataatttttg aactcattag agaaatcagc 2688961 tatcgccgtt ccatcttttt tgatgtcaac gttaacggtg gtgtcagccg gcaatacagc 2689021 tctgaagcca ttcggaagaa tttcagacac aggcccgccc tgtacgaggt attcaagcgc 2689081 ctgcttagcc gtgctctcac ttttaggaag aggcagcgtt tgcgcaacaa catacccgtt 2689141 tttatcaatg agataaagct ccctcataac agtagatgag gcttgatccg cttttgcggt 2689201 atcgcttttt tcactttctg tttttttggc tgctgttgta tttgaattgg cacccgcttc 2689261 atcgttcacg aatgtaacgt cttgaggcgg atcaatttcc tcggctgcct tatcagattg 2689321 aaacaaaccg catccggata aaagcaaggc agaggtgaga caagtggcac caatgactgc 2689381 aggtcctttt ttcagcatac ttttccctcc taaggatgtt tgtactatta tgtatacgag 2689441 cctctttagg aaatagaccg aagaattccg gcaaaacaga aaaaaacccg caacataccg 2689501 ttgcggggaa aactatcttt taatcggttc ttgcagtgag atacattcca catgcccgac 2689561 ttcatggcca aaccaatcgt ctgcgatttt tgcaaactga tcacgcgccc ctgttgtcag 2689621 gaactgatga tccggggcaa tcggagactg gttcagcagc cctttataag agagaattgt 2689681 gctgacttcc cgggctgttt catcgccgga cgaaataatg tttacgtgct ctcccatata 2689741 tctttgaatg gcttctttta aaatagggta atgggtgcag cctaaaatca gcgaatcaat 2689801 tgatgtgtct tttaacggat acagcgaggt tttaacaatc tcgtctgctg ttttgtcgag 2689861 aaacttcccg ctttccacaa aaggcacaag cagcgggcag gcaaggtttt caaccttcaa 2689921 atcagggttt aatgccaaaa gcgcttcttc gtatgcattg ctcttaatcg tattctctgt 2689981 gccgatgaca ccgatatgct gattatccgt cacttttatc gctgctctcg caccaggctg 2690041 gatgactccg accaccggta taccgacgct gcgctggatg tcatccaaag cgatcgctgt 2690101 tgctgtatta caggcgatca cgagcatttt gatgtggtgg ttttcgagta aataattcgt 2690161 cagctcccac gtatattgaa gcacctcttc ttcagggcgc ggcccgtaag gacaccgttt 2690221 cgtatccccg acgtagataa tattttcttt aggtagctgt ctcatgattt ccttcgcaac 2690281 ggttaaaccg ccaaccccgg aatcaatgac tcctattggt tgttccaaca aaatcgcctc 2690341 attttctctt catttcatgc tgcagtttca tcaaagattt ttcgaagatg gctatttctt 2690401 catctgtaaa cgattcgaac atatcacgca gatattcctg tctttttgta atgacctctt 2690461 ggataatccg ttctccttca ggcagcagat gtatcctgac aacacgtctg tccgccgggt 2690521 ccttgacccg ctcaacaagc tcattttttt gcatgcggtc gattaagtcc gttgtcgtgc 2690581 tgcatgccag atacattttg cccgataatt caccgattgt catatctcct aattcataaa 2690641 gccattgcaa gccgacaaat tgcggcggcg taatcgcata ttggttaagg atttctcgtc 2690701 ctttttgctt aatgatcgcg gcaatgtggc ggagtgactt ttcaatatcc gcaacatgct 2690761 ccaaaggttt tgatgtcatt tgtccatccc tcactcaagg atctcttacg cacaaaagcg 2690821 ttccgtgtct attttccttc ttttttgaag aaaatgcaag actcgcagga gagaaataga 2690881 ggactttagt caaacaacat caagaaataa aatttaattt atgacttgcc tacgttttgc 2690941 acagcattcc aaatatggtt tcgaatgttc caaacaaaca gcaataaccg gctccttcca 2691001 aaagaaggaa taccggcaag gattaaagct ctagctcacc cattctaaga agctcaacaa 2691061 cggcttgcga acgccctttc acacccaatt tctgcatggc atttgaaata tggtttcgaa 2691121 cggttttctc actgataaat agctcgcttg caatctcctt tgttgtctta tcttgaacga 2691181 gcaattcgaa cacttctctt tctcttttcg ttagcagcgg cttcgattga aattctttct 2691241 ccttcaagta ttgtaaccct ccttgctaag gtgagagcga atcagaaacg aatgggtttt 2691301 gatatagtcg agatatcata tgtaagaagg gcgcaggagg tgacgtttac aagataatta 2691361 gtttatcgtg tatgaagaag cgtttctttc tcctcatccg tccagctgac agccttgccg 2691421 ctttcctttg agacttgaac catcacgact gccccggtga agcagggttc gccttcgagg 2691481 ttctctccga gatagtgcaa ggtaagagat gaactgccga ctgcgcttgt tttcacatag 2691541 atgcgcaact cttcataagg catgacttgg cgcaaataat cgcattgctg gcttgccacg 2691601 actgtcatgg tctgtttgtt ttcactcatc atattcagct ttttaaaata agaaatccgc 2691661 acctcctcaa aatatataaa aggggttaca ttattcatat gcccaaacat gtctgtctcg 2691721 gaaaatctta cggatacctt attgaaaaaa gaaaaggatg ttttccattc ttgaaacggc 2691781 atatcaatat aagcgggaag cttcatcttt tttcatctcc ttattgttta aaaaaacctc 2691841 tcccatgcgg aagaggtttt ttcttcttat actctgtcgc ttccgaagaa attgcggaac 2691901 gcttgtaagt ttgtatctct attcaaggct gcaatcgaag tggtaagcgg aatccccttc 2691961 ggacaggatt gaacacagtt ttgcgagttg ccgcaatctg caaggccgcc ttcatccatt 2692021 aatgcttcta atcgttcaga tttattcatg gcgcctgtcg gatgcgcgtt aaacaggcgg 2692081 acttgcgaca tcggtgcagg ccccatgaac ttcgatttgc tgttcacatt cgggcaagct 2692141 tcgaggcaga cgccgcatgt catgcatttt gataattcat atgcccattg acgacgtttt 2692201 tccggcattc tcggccccgg tcctaaatcg tacgtaccgt caatcggtat ccacgctttt 2692261 acttttttca atgaatcaaa cattctgctg cgatcaacct gcaaatcacg aacgactggg 2692321 aatgttttca ttggttttaa acggattggc tgttcaagct ggtcaataag cgccgtacaa 2692381 gactggcggg gttttccgtt tataaccatt gaacatgcgc cgcatacttc ctcaagacag 2692441 ttcatatccc atgtgacagg ggttgtcttc tcacctttga cattaaccgg attccggcgg 2692501 atttccatca gagcggaaat gacgttcaga ttcgggcggt atggaatctc aaattcttca 2692561 tcataaggcg tgctgtcagc tgtatcttga cgtgtgataa taaatcgtat ggttttttgt 2692621 tcactcatga ttatttcgcc accttcttct tcgagtaatc ccgtttccga ggcgttatca 2692681 gtgatacatc gacatcctga tactcaaatt ccggcgcttc atacgggctt acatgtttag 2692741 ccattgttgt tttgagccat tcatcatcat tacgttcagg ataatccggt ttataatggg 2692801 cgccccggct ttcattacgg ttgtatgcgc caagggtaat caccctcgca agctgaagca 2692861 tgttcgagaa ctggcgtgtg aacatcgctc cctggttgct ccattttgtc gtgtcattga 2692921 tgttgatctt tttgaagcgc tccattaact cctgaatttt gtcatccgtt ttcaaaagct 2692981 tgtcattatg gcggacaacc gttacgttcg ccgtcatcca ctcaccgagc tctttgtgaa 2693041 gaacataggc attttcggtt ccgtccatac tcataatatc agcccatttt tcttcttctt 2693101 tcttaacgtg agcgtcgaat aaagatgaag acatgtcttc cgctgaagat tctaagccgt 2693161 ttacatattt caccgcattc ggaccggcca ccatgcctcc gtaaatcgca gacagcaggg 2693221 agttcgctcc caagcggttg ccgccgtgca tagaataatc acattcccca gccgcaaaca 2693281 gtccagggat atttgtcatt tgatcgtaat ccacccataa accgcccata gaataatgga 2693341 ccgccgggaa gattttcatt ggaagcttac gcgggtcgtc tcccatgaat ttctcataaa 2693401 tctcaatgat gccgccaagc ttaatatcaa gctctttcgg atctttatga gacagatcga 2693461 gatataccat gttttcaccg ttaataccga gcttctggtt cacacacaca tcaaatattt 2693521 cgcgtgtcgc aatatcacgc ggcaccaggt ttccgtatgc cggatatttt tcctccagga 2693581 aataccatgg tttgccgtct ttatatgtcc acacgcgccc gccttcacca cgcgctgatt 2693641 cactcatcag tcttagtttg tcatcgcccg gtatggctgt cgggtggatt tgaatgaatt 2693701 ctccgtttgc ataatacgct ccctgctgat aaacgattga cgcagcagat cctgtattaa 2693761 tcatggagtt cgttgatttt ccaaagatga ttcccggtcc gcccgtcgcc ataatgacag 2693821 cgtctgaacg gaaggattca atttgcatgt ttgtcaggtt ttgtgcaaca attccgcggc 2693881 aggttctgtc atcatctaaa acagcgccaa ggaattccca gccttcgtat tttgtgacca 2693941 gacccgcaac ttcgtatctg cgcacttgct cgtccagtgc gtaaagcagc tgctgtcccg 2694001 tcgtcgcacc agcataagca gttctgtggt gctgtgtacc cccgaatcgg cggaaatcaa 2694061 gcaggccttc aggcgtccgg ttaaacatga cgcccatccg gtctaataag tggatgatcg 2694121 aaggcgccgc ttcacacatc gccttgaccg gcggctggtt ggcaagaaag tctcccccgt 2694181 ataccgtgtc atcaaaatgt tcccacggag agtcaccttc cccttttgta ttgaccgctc 2694241 cgtttatgcc gccttgcgca caaactgaat gagaacgttt gacaggaacg atggaaaaca 2694301 atttaaccgc cattcctgat tccgctgctt taattgtcgc catgaggccg gcaagacccc 2694361 cgccgactac gataatgctt gattgactca tgatagcccc tctccctcta gtaatctagt 2694421 actcttaaac aaatgcaaaa atcgctttta agcctacgta tgacagtgca acaaaaataa 2694481 tcagcgtaac gtatgtcgaa attctttgag aacgaggcgt taccgtgatg ccccatgtaa 2694541 cagcgaaaga ccataaaccg ttcgagaagt ggaaaattgt tgataaaaca ccgacaatgt 2694601 aaaaaccaag catagccgga gagctcaaaa tattcgccat catgtcgaaa ttgacctcag 2694661 cacccatttg tgcggcaatg cgggtttccc acacgtgcca gctgacgaaa atgagggtga 2694721 tgataccggt tacacgctgc aggacgaata gccagtttct catgtagctg tattgaccgg 2694781 cgttattttt cgcagtaaac gctatgtaca caccataaac tgcatgataa attaatggta 2694841 agaagataat aaaaatttcc aaggcatacc tgaaaggcag gctatccata aaatgagcag 2694901 cgctattgaa tgcttcagcg ccccttgcgg caaactggtt gacgactaaa tgctgaataa 2694961 gaaagatgcc gaccggtatg acgccaagca aggaatgcaa tcttcgaaaa taaaactctc 2695021 tgttcccaga cattacttta ccccctgttt gataagtgcg aaatgtgcta aatctcttcc 2695081 cccacttctt tcaattgtaa gcactttatt aagatttatt gacaatttca ttttactcct 2695141 ccctcaaaag ggcgtcaaga aaacgcgtac ataaattata attttccgaa ttgattagtt 2695201 gattgaaaaa ttttatttta tcaatatata tttcttgctt aatttttcat aagaattaca 2695261 ggatcattct gtaatcctcc cccctgtttg agctataata tacgcaggag agaggggaga 2695321 cagatatgaa gtctaaattt gaagcatcta ttgacaacct aaaagaaatt gaaatgaacg 2695381 cttatgccta cgaactaata cgagagatcg ttctcccaga tatgcttggc caagattact 2695441 cttccatgat gtattgggca ggaaaacatc tcgcccgtaa gtttcctctt gaatcatggg 2695501 aggaatttcc ggccttcttt gaagaagcgg gctggggaac cctcaccaac gtaagcgcta 2695561 aaaaacagga gcttgaattt gaacttgaag ggccgatcat ttccaaccgg cttaagcatc 2695621 agaaagaacc ttgctttcag ctggaggctg gttttatcgc tgaacaaatt caattgatga 2695681 atgatcagat tgccgaatca tatgaacaag tgaaaaagag agccgataaa gtggttctga 2695741 ctgtgaaatg ggatatgaaa gacccagtgt aatcaaaaag gcggtgactg catagtcccg 2695801 cctttttgat tgtcattaca cagctgaagg gtgttttgaa agctcaaatg catcgtgaag 2695861 cgactcgact gctttcacca tgtcattttc gcttacgact gttgacactt tgatttcaga 2695921 tgtgctgacc attttgatta aaatgttttt ttgcgccagt acagcaaaca tttcagccgc 2695981 tacaccggga tttgagacca tgccggatcc aacaatagat actttagcca atttgctttc 2696041 tgtctcgatt ttctcaaatt ccagcgcgtc tttatactct tcaagcaccg caacggtttg 2696101 gtctgcatct tctgttttga cagagaagga aattccagtc ttgtcctcgg cctgcgtttg 2696161 gataatgata tccacgttta tgtttctttt ggcaagtgtt gtaaaaatag tagacaaagt 2696221 tgtcaggccg ctagtcagcc cgtaaatggt tactcttgtg atttgatctt caaatgcaat 2696281 gcctctgaca attaaattct gttccatgga tgattcctcc tcaattaatg ttcccgcttc 2696341 ggtttctgta cttgaacgca cttctaacgg cacttggtaa tttttcgcga actcaactgc 2696401 tctcggatga agaacaccgg cgcctaaatt ggcaagctca agcatttcat cgtatgagat 2696461 gccctcaagt tttctcgctg atttcacata gcgcggatcg gttgtaaaca cgcctggcac 2696521 gtctgtgtat atgtcacatt tatcagcttt taaagcggca gccaaagcaa ctgctgttgt 2696581 atctgaaccg ccccggccca atgtcgtaat ttcacaatcc tctgtcatgc cttggaatcc 2696641 tgcaacaatg acaatttttc ctttttcaag ctggtctgct aaaaccgaag tgtcgatatc 2696701 tgtaattctg gcgtttccgt gaatggcctc cgtacggatt cccgcctgcc agccagtata 2696761 agacacagcg tcatagcctt tttcctgcaa tgccattgaa aggagtgaaa tcgtgacctg 2696821 ctcgcctgtc gccagcagca tatccatttc gcgtttgctc ggctggtcag aaatagcttt 2696881 tgcaaggctg accaattcgt cagtggattt tcccattgct gaaacgacga caacgacttg 2696941 atggcctttc tgtttttctg caattgcgcg gtttgccgca ttttgaattt tttcgactga 2697001 gccgacggaa gtgcctccga atttttgtac aataagaccc atgtattacc accctttaca 2697061 ttttggttcg tgcgggtgag gagaaagagc gctttgtcca caataaaaaa agcaatgaga 2697121 ggaatactct cattgcttat caattaatca tcataaatga ttatgaacaa cgagatagcc 2697181 ctccaagaaa atgatttctt gacagcctta catttattca atgcacggcc agcaaataat 2697241 accgatgggg ttttatttgc ttcggcgacg ctcccctttc agcctttttc acagaatcca 2697301 tctttctcca aaggcatact cttgaagttc gcacctctat cttcaccata taacacgatc 2697361 taactatgaa attagttcac attttatcag atcttattta aaaggacaac attatttttg 2697421 caatttgtcg taaaggagct gagccgccgc tgcgggaaca ccggcttttt tgatgtcctc 2697481 aaggcttgct tccttcattt ttttaacgga accgaaatgc tttaacagca ttttctttct 2697541 tttctctccg atacccggga tgtcgtccaa aacggattga aacgcgcttt ttccccggat 2697601 ttgcctgtga aaactgattg caaaacggtg cacctcgtcc tgaatgcgct gcaggaggta 2697661 aaattcctgg ctgtttcgtt ccagatacgc cacctccagc ggatcaccga tcagtaaatt 2697721 tgaggttctg tgtttttcat ctttcgctaa accggcgatc gggatatcca agccgagttc 2697781 attttcaatg acatcccttg ctgcgttgat ctgccctttt cctccgtcaa tgataatcag 2697841 atcgggcagc ggcagattct cacgaagcac tctcgtatag cgtcttctga caacctctct 2697901 catagaaccg taatcatccg gccctgtaac agttttgatt ttatatttgc ggtattcctt 2697961 tttgtatggt ttgccatcga taaacacaat catcgcggaa accgggtttg tcccctgtat 2698021 atttgagtta tcaaacgctt caattctgtg cggcgtataa atatttaatg cctcacctag 2698081 tttctgcact gccccgattg aacgctcctc gtcccgttcg attaaagaga atttttcttt 2698141 caatgcgatt ttcgcatttt tatgggcaag catgagcagt tcttttttcg ggcctttttt 2698201 cggctggtga acgtttgttt ccagtagctg ctcgatcata gattgatcta tgctgtccgg 2698261 aactaaaatc tccttcggaa ggaagtggtt gttttttgaa tagaactgcc cgatgaacgt 2698321 gaggaactct tcatctgctt cctgataaag cgggaacatg ctgacatcgc gttcaatgag 2698381 ctttccttgg cggatgaaaa agacctgcac gcacatccag cccttatcgt acgcgtacgc 2698441 gaacacatca cggtcgacta gatcgttcat cgtcattttt tgtttttcca tcgttgattc 2698501 aatatgggca atttggtcac gaagctcttt tgctcgttca aactcaagat tctcagcagc 2698561 ttcatgcatt ttctcttcaa gctctttttt gacctcatta tagccgcccc ttaagaaacg 2698621 tgtaatgctt tcaaccagct ctctgttcgt ctcttcggaa atatccttta cacacggagc 2698681 aaggcattgg cccagatgat agtaaaggca cactctgtcc gggagcttgg agcattttct 2698741 gagaggatac agacggtcga gcagtttttt tgtttccctt gctgcctgta cattcggata 2698801 cggcccgaaa tagcgccctt tgtctttttt gacattgcgg gtgacaatca gccttgggtg 2698861 gcgttcatgg gtgagtttta tgaaaggata ggttttgtcg tctttgagca tgacgttgta 2698921 tttcggatca tgctttttga tcagattcat ttctaaaata agcgcttcaa gattggagga 2698981 cgtcacaata tattcaaaat cctcgatttc cgtcacaagc ctttgggttt tcgcgtcgtg 2699041 agaaccggtg aagtaggagc gcactctgtt tttcagcact tttgctttcc ctacgtagat 2699101 cacagtctgc tgccggtcct tcatgagata acaacccggt tgatcaggaa ggagggcgag 2699161 tttttctttc agttgtttgt tcatatgtta cccttcctta tgtttaatcc tttatttcca 2699221 gtttaacacg aacgtttgtt tttctctatg gttcacaatt ggcgaataaa aaaagcgatc 2699281 cctcaatcgg aatcgctctg gcatgtaagc agcggaaaat taaagatgtt tgtttacaag 2699341 ctcttgaagc gcttcttttg gtttgaagcc gactgaagtt tcaactactt cgccgtcttt 2699401 taacacaaga agagtcggga tgctcataac gccgtatttt ccggcagttt cttggttttc 2699461 gtctacatcg atttttacga ttttcagttt gtctcccatt tcttgatcca attcttcaag 2699521 aacaggtgca atcattttac aaggtccgca ccaaggagcc cagaagtctg ccagtacgac 2699581 gccttcgctt gtttcagctg agaaagattg atcagttgct tttacgatag ccattattga 2699641 attcctccaa tgtgaaatga tgatttttag tatagcatct cccattcgtt cacgctattt 2699701 taatgcttac aaattatttt ttcctgatca cagccggttt actcattttt atatggttga 2699761 atgggatatg ctcttttttt aaaacacaaa tctgataatg gccccgatca ctacaattgc 2699821 cccaataatc attaaaatgg tacgaagcat aagatcacat ctcctcttca ctgtcatgta 2699881 ctttaccatg ccctgccgga gctgttttaa aacctgaaaa agagcgccgg catgaagctc 2699941 cggcgctctt gcgcgattaa gaatcagcac gcagcgtaag taagacgact gacattggcg 2700001 ggagttttac tttcagtttg tttttgctga gcgtgtattg tctgaaggat tccggtttga 2700061 catgatgagg atcgtcaaac gtgttatgcg cattcatttt ttctgccgta agaatgactc 2700121 cggaatggtc cgctgccttg tgtaggcccc tcagctcgat ttccgcctct gctttgtttt 2700181 ggtgatcgat gttgcaaatt gtgatattga tatcgccttc agcttgtttc gacgctgaaa 2700241 tgctgatttg cggaagcgtt tcaccgttcc attcatagtc ggcagacatt gtctctgtgg 2700301 ctaaaagaga agcgtcctgg tgcaccttaa acatattgaa tacatggtac gtcggtgtca 2700361 aaagcatccg ctctccctca gtcaaaatca tcgcttgaag aacatttact gtttgggcga 2700421 tgttggccat ttgcacccgg cggcaatgct gatggaaaat gtggaaatga gaagccgcca 2700481 ccagtgcatc acgaatggtg ttttgctgat ataagaaacc gggattcgtg cctggctcgg 2700541 gatcaaacca cgtgccccat tcatcaataa tcagcccgac ccgctgctcc ggatcgtacc 2700601 ggtccataat cgtgccgtgt ttttgaatca attcatcgat gtatttggct tttttcatcg 2700661 taataaacca ttcatcttcc gtgaattctg tggctgatcc tttgcccttc cagaaatccc 2700721 ccggaatcgt gtaataatga agactcaacc cgtccatcag gccagcggct tttttcataa 2700781 gcacgtccgt ccaattaaaa tcatccacat ttgcgccgcc tgcaatttta taaatgtcat 2700841 tcccgctgta attgcggaca taagtctgaa aacgccggta cagatctgcg tagtattcgg 2700901 gatgcatgtt gccgccgcag ccccagtttt cattgcccac gccgaaatat ttcagcttcc 2700961 aaggctcttc tcttccattt tgctttctcc agtctgacat cggcgtgcct tcttcaaatg 2701021 tcatatactc aatccactcc gacatttcct gaacggttcc gcttccgaca ttgccgcaaa 2701081 tatatggctc gcattcaagc agctcgcaaa gcatcataaa ttcatgcgtt ccgaattcat 2701141 ttgattcaat tgtaccgccc cagtgagtgt tcagcattgt cttacggtca ccgacaccgt 2701201 ttgcccaatg gtattcgtcc gcaaaacacc cgcccggcca cctaaggaca ggaatgtgca 2701261 gctgtttgag cgcctccagc acgtcctttc gtatcccgtt gatattgggg atgtctgagt 2701321 ccgttccgac ccagatcccc tcataaatcc ctcttcctaa atgctcagca aaatgaccgt 2701381 atatattttt gttaatggtt ccttttgcga tatctgtttg aatcactgct tgatgttcag 2701441 acatgcctct gatcattcct ttcatacgga tatgaaaagc accacagtca aatatgtgat 2701501 ctgtcgtttg cctgaggagt cagcatgaat gtaagcgctt ttaaagtaac catattatat 2701561 atgttcgtac atgtcaacga cattttctat tgtttttata tttgtacgta tgtatttata 2701621 aatatgaaaa aacccggact tttaaagtcc gggatttcct ttatgagtgt atattcagct 2701681 gtttgaattc ctcagttaat aacgggacaa cttcaaataa atcaccgacg atgccgtaat 2701741 ccgctatttt aaagatatcg gcttcggggt ctttattgat ggcgacgatc accttgctgt 2701801 ttgacatgcc ggccaaatgc tggatggcgc cggaaatgcc gcatgcaatg tacaaatccg 2701861 gagtaacgac tttcccggtc tgcccgattt ggagagcata atcgcaataa tcagcgtcac 2701921 atgccccgcg agaagccccg actgcggccc ctagcacctc tgcaagctcc tgcagcggct 2701981 gaaatccttc cttgcttttg actcctcggc cgcccgcaac gataattttc gcttcggaga 2702041 gatcaacacc gtccgccgtt tttttcacga cctcttggat aacagtgcgg aggtcagtaa 2702101 gagaaacatc aatgctttcg atgctccccg atctgctggt gtctttttct gaagcttgaa 2702161 tgttattggg gcgaattgtt gcaaagatca tcggatcggt tgaaatgacg cgttcaaaag 2702221 ctttccccga gtaaatcggc cgtgtgaaca caacattccc tccggtaacg cttacatcta 2702281 tagcatcaga aattaagcct gtttgcagac gggcagcaag cttcggtgaa agatccttgc 2702341 ccattgccgt atgcccgaag atgactgaat caggattttc ttgctcgata acacctctca 2702401 tgacctggct gtacccgtct gccgtgtatg ttttcagctt cgggtcctca gcggtaagaa 2702461 ctttatctgc tccgtaatga ataagctctt gtgcaatgct ttgtacattt tcaccgatga 2702521 gaacaccgat gacttcccca tctcctgaaa tggttcttcc tgcagctatt gcttcaaagg 2702581 tgacatttcg caattcccca tcgcgtattt ctccaagcac gatcactttt tttcccattc 2702641 taacatcccc ctgtttcttt gaatgtccaa gttttaaatg actttagctt cgctgcggag 2702701 caatgaaaca agctcttttg cctgttcagc aggctcacct tggagaagct tcccggcttc 2702761 ttttttcggc ggcagaaaac gttcaatggt tttcagcttt ggttcagcat cctcttcgtc 2702821 cagatcaaga tcatcaagtt caagctcttc aagcggcttt ttcttagcct tcataattcc 2702881 cggaagcgat ggatagcgcg gctcgtttaa gccctgctga gctgtgacaa gcaatgggag 2702941 cgtcgttttg attttttcaa catccccttc gacgtccctt tctgcttctg catcagtgcc 2703001 gttgatttcg agtttggtga tcgtagtgat acacggaatg tccagtagct cggcaagccg 2703061 aggcgccact tgtcctgatc ctccgtcaat ggcaacattt ccgccgagaa tcaaatcaaa 2703121 ctcctgatcc ttcatatagt ggtataaaac ttgagaaatg gaatattggt cgggttcatc 2703181 aagatcatct tctatgttga ttaaaacagc ttggtcacaa cccatggcaa gcgccgtacg 2703241 caattctttc tccgcttctt caccgccgac cgtgacagcg gtgatcgtgc cgccatgctt 2703301 ttccttcagc tggatggctt cttctatcgc gtactcatca tatggattaa tgatccattc 2703361 cgctccgtca tcctgaatct ttcctgtttc aatgacgatt ttttcttctg tgtcaaacgt 2703421 ccgtttcatc agtacaaata gattcatgat catatcccct tttattcgcc tttgaactga 2703481 ggctttcttt tttcgagaaa tgcctggatg ccttccttgg cgtcctctga ctcaaatgct 2703541 tccccaaatc gctttgcttc aagctttaag ctgccttcat aggaatacac cttgttggaa 2703601 taaagaagtt caagcaaaga tgccagcgtt tgcgggcttt tctctgcaaa cttagcggca 2703661 agtgcttttg ctttttcaat cacttctgcc tcatctttcg ctccaattga gacaagtccg 2703721 agatcaagcg cttcttttcc ggatatcggt tctcctgatc cgatgagctc cagtgctttg 2703781 gctgtaccga catatctcgg aaggcgctgt gtccccgcaa aacctggaat gataccgaga 2703841 ttaagctccg ggagccccag cttagcatct tctgccgcga ttctgatgtg acaggccatt 2703901 gcaagctcca gcccgcctcc gagagcagcg ccgtgaatcg ctgcgataat cggttttgga 2703961 aaactttcga ttctctccat taactgctgg ccgcgctcag cgagcaatga ggaatcctca 2704021 ttgcctttaa gcgatgtaaa ttctttaata tcagcgccgg ctgagaaaaa tcttccctcg 2704081 ccgtgaatga taatgcttcg tacgcctgca tctgtctcac attgatcaag acaggaagac 2704141 agctcttcta atatccggct tgaaagcgcg tttgccggcg gattgtgaat cgtcaagact 2704201 gccacaaatt gatcaaccgc aagtgaaatt gcattcatag gacagaactc ctttacttat 2704261 tgtgaattcc ggataccaat aattctaaaa cgctgtttga aagcgcaacg agatcgtact 2704321 tttggtcatt catcacccaa gttgtcacag tttcgtcaat cgttccaaaa atcatctgcc 2704381 gggcgaggcg gacatcgagg ccttctttta tttcgcctga ttgtatacct tccgtcaaaa 2704441 tgccatccaa aatatttaag tagcctttta atatttcgtt gattttttgg cgcagctcca 2704501 agttggattg gcggagctca agctgcgtga caatggcgag attatggtca cccgctaaaa 2704561 gggaaaaatg ctttgaaatc acaagcgcca atttctcttt cgctgttgct ttttctttaa 2704621 tgtcctcttc catccgctca ataaattgac ccattttttc tttgaaaaga gaaattaaaa 2704681 tatcttcttt gtttttaaaa tagagataga tggtgccgtc cgctaccccg gcttgtttgg 2704741 caattttgga tacctgtgac tggtggtagc cgttttctgc aatgacttct actgctgcat 2704801 caataatctg catatacttt ggccgttttt gcttcaatgt tcatcgttcc ttcctataga 2704861 aatgaatgac tattcattca taatttcatg ataagaagga ttttcaggtt tgtcaagttt 2704921 attcataggc gttctctttt tttatttgat atgatgattt tcggtttctt cttcaagtaa 2704981 acgccttctt aaaatttttc ccaccgccgt tttcggcagc tcctttctga actcataggc 2705041 tttgggcacc ttatagggag ctagacgtga tctcgcaaaa gcgtccagtt cttctgtatc 2705101 ggcttttgcg cctttcttta atacgacaaa tgcttttact gtttctcccc tgtaggaatc 2705161 gggaacgcct gcgacaacaa tttcctggat ggcttcatgt tcataaagcg cttcttctac 2705221 ctcacgcggg taaatattgt aaccgccggc aatgatgata tccttcttcc tgtcagcaat 2705281 atagaaaaag ccttcttcat ccatatagcc catgtccccg gtgaacagcc agccatctct 2705341 cagcactgcg gcggtttcct ctggtttatt ccagtatcct ttcatgactt gcggaccttt 2705401 tacaatgatt tctccatgct catacggagc ggcaagctca cccgtctctt cagaatagat 2705461 cgcagcgtcc gtactcggcc aaggacagcc gatactgccc ggcttgtttt ttccccagat 2705521 aaagttggcg tgcgtcactg gggatgcctc agacaaacca tagccttcca caagctttcc 2705581 accagtcacc ttttcaaatt tctgctttac ctccacgggg agcgcggctg atccgctaag 2705641 acagctttta atggatgaca gatcataatg ctgcaattca gggtgatgca aaaggccaat 2705701 gtaaattgtc ggtgcgccag gaaagagcgt cggtttgtgt ttgtcgatga ttttaagtgt 2705761 ttcgagcgga tcaaacttag gaagaagaat catttcgaag cctagtttaa tcgaatagtt 2705821 catgactgcc gtcagtccgt agacatgaaa aaatggaacg atgcccagca ctttttcagc 2705881 gccttctttc acgtcataca tccaagcggc gcacatttca gtatttgcca aaatattttg 2705941 gtgcgtgagc atgacccctt ttggagctcc ggttgttcct ccggtatact ggaggacagc 2706001 gatatcatgc tcaggatcga tcttcgggat tgtcaggagt tcagtttttt cctgcttcat 2706061 acaggaagcg aacgtgtgaa tgttagctgt tttgtcaaag tcgatatgca ctttttgttt 2706121 ttgcgtcagc gggtaaagaa tatttttcgg aaaaggcaaa tagtctttta cactggttat 2706181 caaaatctgg tcgactattg ataacgtttt catttttatt gccttcggga aaagcaaatc 2706241 taaggtgatg attacactta cctgagcatc tctaagctgg tattcaagct catgctcggt 2706301 ataaagcgga ttcgtctgca ccacgatgcc accggcaaac aagacgccat aataagaaat 2706361 cactgtttgc gggcaattgg gcagcataac agccactctg tctccttttt gcaggccatt 2706421 gcactgcaaa aaagctgcaa gtttaagagc atccgtcaga atgtcatgaa aggtgagttt 2706481 ttttccataa aacgatattg cggttttatc agggaatcgt gcggcggagt ctgtcaggat 2706541 ggattgcagg gttttattcg gcaacggaag ctcatgcggg atatcgttgg gatactcggc 2706601 aagccacggc ttttgagact gcataaaacc tcccctttcg attttagaga tccaccttat 2706661 cattatagca gatggacggc aaaaaaaaga aaaagaaagg taaatctttc tttttctcat 2706721 aatatgaaca gatatataag accaattaac aaaaagattc ccgctgcggc gagcagtatt 2706781 ttcgcaagct tttccatcta ttctccgtcc ccttatattc cggctgccac cacaaaagaa 2706841 agcccgacag aaatgacaaa tgaaataaag ccgacagccc ggttatcatt ttcgatttcc 2706901 tgatcaattt taaaccgcgg agtcaaaaac tcaaaaataa agtagctgat cagaagcata 2706961 acaaacccgt aaacgcccca gccgatcatt tgcagcagcg aattatgctg ggagatggaa 2707021 tgctgaaata cgtttgcgat tcccaaaatt tttccgccgg tcgccattgc caccgcaaga 2707081 tttccttttt gaatctcttc ccagttttta taagccgtca ccagctcaaa cacagtcaaa 2707141 aagaggacga ggcagagaac cgcgacactg taatatgccg cgatttccac aagctcgttt 2707201 tcccaaaaat cactcatggc catactccct tttattttag ttcaacaacc gtaacgcctg 2707261 atcctccctc acctgcttca ccgaaacggg aacttttgac gctgcggtgg tttttcagaa 2707321 gatcctgtac gccttttctt aaagcgccgg ttccttttcc gtggatgatt gacactcttg 2707381 gatatccggc taacaccgca tcatccaagt atttttcaac ccggctgagg gcattttcat 2707441 agcgttcgcc gcgaagatca agttcaagcg atacgtgata gtcctttcct ttgaccgctg 2707501 taatcatttt ttcttttttt ggctccggag ctgatttgat aaactccaga tctttttctt 2707561 ttactttcat ctttaaaata ccgatttgaa cgttccattc attgccgcct gttttttcga 2707621 gcaatgttcc tttttgcccg aaagtgagga ctttcacctc gtcgccaggc ttaaagtcgc 2707681 gtttttgcgt tttcggcttt tccggtttct tggacttttc aaaagcaggc atagcgcctt 2707741 ctaaccgttt cttcgcgtta atcagctcgt gatccttgaa ggatttgtgt tcttctttta 2707801 tggtgcgcaa ttcatgaata atgtcctcgg cttctttcat tgccgctttt actttttcag 2707861 cagcctgctg ttctgcctct tcaagcattt tgtctttttt gctgttaagc tcgatgattt 2707921 gctgctgcag ctctttatgc agtttttccg cttcttttct gattgattct gtctcagaaa 2707981 gctcttcttc cgcacgtttt ttgctttgtt ccagcgacgc aatcatcgta tcgacttcgt 2708041 tatgctcggc cgtcatttct gacttcgcct gcccgatgat atggtccggg agcccgaggc 2708101 gttttgaaat ttcgaaagca ttgcttcgac ccggcacacc aattaaaagt ttataggtcg 2708161 gtgacagcgt ttcgatgtca aattcaacgc tggcattcat gacgccttct ctgttatagc 2708221 cgtacgcctt caattccgga taatgcgtcg tagctaacac tcgtgcattg gtgcgatgca 2708281 cgtcatccaa gatgctcatg gcgagggccg ccccctcctg cggatctgtc cctgcaccaa 2708341 gttcatcgaa aagcacaagg ctgttttcat tgacctgttc taaaatgccg acaatattca 2708401 ccatatggga tgagaacgta cttaaacttt gctcaatcga ctgttcatca ccgatatcag 2708461 cgaatacgtg ctcaaatact gccgcttctg acccttcatc tgccgggata tgaagacctg 2708521 actgcgccat taaggttagc aggcctaacg ttttaagggt gactgttttc cccccggtgt 2708581 ttggccctgt gatgacaatg gttgaaaaat cgcggccaag ctcgatgtca ttggcaacaa 2708641 cctgatcagg cggaagcaat ggatggcggg cttttttcaa acggataaag ccggtgtcgt 2708701 tcataatcgg ttttgtcgct ttaaccgctt ttgcatatct agcttttgca aaaataaagt 2708761 caagcgtctg cagcacttgc aaatctagaa atagctcctc tgtatactct gccgttttct 2708821 ctgtcagcac acgcaaaatc cgttcaattt cttgcttttc tttcactttc gcctgctgaa 2708881 gggaattgtt catatctaca atcgcctgcg gttcaatgaa tagtgtcgca ccagaggatg 2708941 aggtgtcgtg cacaattcct ccatagctgg atctgtactc ctgtttgacc gggatcacaa 2709001 agcggtcatt ccgaatcgta acaatcgtat cagacagcat tttcgatgcg gaagaggaac 2709061 gcagcatcga ctctaaccgg tctctgactc ttgattcgag tgttctgagc tgtgtgcgga 2709121 ttcctcttaa tgtttccgat gcatgatcaa gcacttctcc gtgatcatca atgcaggaat 2709181 taatgtcccg ctctaaatcg gacagcgtga taagctgttc agcatgctga tggatcagcg 2709241 gaatgtcgac accgtcttca gccatttgcg tgataaaatg tttcatttgt ttaactgcat 2709301 aaagcaggcc tgagatttca gtgaattcag aaggactgag aacgctgccg atttccgccc 2709361 gtcttaacgc tcctctgata tctacaaggc cgccaaatgg cgcttggcct ctcagccgga 2709421 taatgtcaga agcttcgtct acttcatcca gctgtttttt gatttcgtct atagaagcag 2709481 aaggcttaag ctcgagaagc atttcttttc cgagcgatga agcggcatgc ccaataacct 2709541 gttctttcac tttatgaaat tcaagagctg ataatacttt ttgctgcacg attgtgtgag 2709601 cctccttact taatcgttgc gcttcagaaa tgcctctacg tctttaagcg accgggcatt 2709661 cagaacgttt ttcgtttccg tccatccttt gcgcgcggca gtaacgccag ttttcatatc 2709721 gtctaacatc tcaatattat gggcatcagt attaatcacc aatgtaaccc cttgttcgtt 2709781 tgctttcatt aaatgctctg tgcgcagatc aaggcgcgca gggttggcat tgagttcaag 2709841 cgccgtattt gttttcctcg caagctcaat cagctgatca atatcgattt cgtaaccggc 2709901 ccgtctgccg ataaggcgcc cggtcgggtg tgcgataatg tcaacatgct tgtttgtcag 2709961 tgccgtctca agccgtttca taatcacgtg ttccggctga ttaaaactgg aatgaatcga 2710021 tgcaataacg atatccattt ccgcaagcac atcgtcatca taatcgagcg taccgtcagg 2710081 caggatatcc atctcaacgc ctttcaaaat acggaagttt tcaaactctg cattcagcgc 2710141 gtcaatttct tttgcctgct gcttaagtct ttctgcagta agcccgttgg cgacctttaa 2710201 atattgtgag tgatcggtga tcgccatgta ttgatagcct tttttgatgc aggcttcagc 2710261 catctctctg atcgaaaatg cgccatcgct ccacgttgag tgcatgtgga gatcaccttt 2710321 gatttgcccg agctctatca gttcaatgct gtcgctgtag gtttccactt cctgtccgct 2710381 ttcacgaatt tccggcggaa tcagcggcag gccgaagtgc gcataaaatt cacgttcact 2710441 cggaaatgtt ttgatctctc cggtttcaac tgtctcaacg ccgtattcac tgatccgctc 2710501 gccgcgttct ttggcgattt ggcgcatctt aatattgtga tcctttgatc ccgtaaaatg 2710561 atggagtgtt gtcggaaact gctcttccgt cacaagacgg aaatcgacgc ttgtttcata 2710621 ttcaaaggaa aggatgacgg acaccttcgt atctccgctt gcgatcacgc ttttgatgtt 2710681 tggcagctca agaagctgct ctcttacttc agccggatga tctgtagcaa tgatataatc 2710741 cagatccttc accgtttccc gcgctctgcg gagacttccg gcacgagaaa atttgatgat 2710801 atgcgtaaat tgagaaagat gctcctcaat ttcccgcgcg atccggaggg cgtagccgat 2710861 cgggaaccgt tcaggctgtt ttccggcttc cccgagcgcc tgtaatattt tttcttccga 2710921 ttttttgccg aagcccgcaa gaccctggac cttttgctgc tcacaggctt ccttcagaga 2710981 ttctgcatcg tgtacgccga gctctttata cagctttgcg atttttttgc cgccgagccc 2711041 cggcagcttc aataaaggca cgagtccttc cggcacttct ttctgaagcg attcgagcgt 2711101 gcttgacttt ccttcatcta tatactcttt aatgacgctg tacgttcctt ttccaatgcc 2711161 ggacagcgac atcatatcgt ccatttctga taagcttcgg tcgtcctgtt ccagagctgc 2711221 cgccgctttt cggaaggcgg atactttaaa cgggttgtcc cctttgagtt ccatatagac 2711281 tgcaatggtt tcaagcagcc ggataatatc ttttttatgc atatcataac ccccagacgt 2711341 tcacatatgt ttccatcata cttgaaaaaa acttctccgg acaagagaag tttttttatg 2711401 ccccgtactg tgtccacagc tcttgtaaaa gccctgacaa gtacggtgta tggttaatga 2711461 tcacatttgc gagagacgat tgccccatca tttgctgcaa cgcgtctacc ggcagaacgg 2711521 atgcgacata cagcagcaca aatgtaaata aatagacttc tagaaaaccg agaacggctc 2711581 ccagcatctg gttgatttgt ttaatcaccg gaatgccggc tacaatactc aggaacgagc 2711641 cgatgattct cagtaagatt ttagcaatga taaataaaac gataaacgca atcgcattat 2711701 agtacgctgc ttccaaattc cccgtaaaaa aagaaagagc cggctgtccc gctgaaaaat 2711761 cgggtgcggg aatccaatgt aaatgcggtg ccacgttttt atagaataaa gccgcaaagg 2711821 caattgataa aataaagctc gtcaagcgga taaactgcag gataaaaccg cgttttaacc 2711881 ccagtaaagt ccccatcagg agcaagatta agatgatgat atctagcata gttgttcaat 2711941 ccttttcttt aagctgacgc tccagttttt cacatttctc ttgtaatttg acataatcgt 2712001 gcaccacatt taccgctgtc agcactgcaa gtttatttat atcaaggtat ggattttttt 2712061 cattgatttc tctcatttta tcatcaacaa ttccggcgac atacctcata tgggctctgc 2712121 tttcttcacc gacaatcgtg aagtgctggc cgtaaatgtc aacggttgtt tttgtttttt 2712181 tgccgtcaga caacgtttct cctccattcc gcgagaatcc tagttcttat cataacacgt 2712241 ttattaaatg aatggaaaga cgagcctccc gctgttatga tacactggta tatacagcga 2712301 aaagtgtaaa aaaaggagat tattacgtgt cccattcagt gataaaagta tcgttgtctg 2712361 ctattgacca aatgaaaatg acgtacagcg gttcacttac agcctctgtt ccgcagggag 2712421 ccgtttttca ggcaaaaccg cccggctgta ccattacagc atatcaatca ggtaaggtct 2712481 tgtttcaagg aaaaaacgct gcggcagaat ccgcgcgctg gggaacagca gagcctcagg 2712541 aaaagaagaa aacggccaaa aagccggctg atccccgcta tgcccctccg gcagatatcg 2712601 ccggaatgtc tgttatcggt tctgacgaag tcggaaccgg agattacttt ggcccaatga 2712661 cggttgtatg cgcgtacgtc gacaaaacca tgcttccttt aatgaaggaa ctcggtgtta 2712721 aggattctaa agatttaaaa gatccgcaaa tcatcgagat tgcccgaaac ctgattaaaa 2712781 ccattccgta cagcctgctg gtgttaaaga atgaaaagta taacagcatg caggaaaaag 2712841 gcatgagcca agggaaaatg aaagctttgc tgcacaatca ggcgatcaca catttattaa 2712901 gaaaattgga tggagtaaag cctgaagcca ttttgattga ccaattcgct gagccaggcg 2712961 tctacttcaa tcatttaaag ggcagagaca ttgtgaagga gcggacctat tttagcacaa 2713021 aagctgaagg tattcacctg gctgtcgccg ctgcttcaat cattgcaaga tattcatttt 2713081 taatggaaat ggataaacta tcacgcgcgg caggaatgac gcttccaaaa ggggccggtc 2713141 cgcacgtcga tgaagcggcc gccaagctga tcctcaaaaa aggggcatct gcactcagaa 2713201 cctttacaaa actccatttc gccaatacgc aaaaagcgca gcgccttgct gataaaaaac 2713261 gttcatagaa aaaagcttgc agatttctct gcaagctttt ttatcagcct cttaaaacag 2713321 cttgatatgt gtcttctaac gctttcagca ctttgctgtg cgcctttgtc acttcttctt 2713381 cagtcagtgt ttgttcagga ttgacatact ggagtgagaa agcgactgac ttcttgcctt 2713441 cctccatatg ctctccttcg tatacgtcaa atacggttac ctctttcaga agcttgcccc 2713501 cggcctcttt aatgacgctc tcgagctgtc cgcttgtgac ggttttatct gttacaagag 2713561 cgatatcacg tgtcacagac ggatattttg gaatcgccgt gtaaacaagc ggtgctgttt 2713621 ctgctgcgag caacgcatga agatcgagct caaatacgta tgtttccttt atatccagtt 2713681 ctttttccaa tgaaggatgg acttggccga tgaagccgat cagagaacca ttcaataaaa 2713741 tgttcgctgt tctgcccgga tgcagctgtt tgcgttcaga ctgtacaaat tcaatgctgt 2713801 ctaggacgtt gagtttgtct aacagccctt ccacaattcc tttgacaaca aagaaatcaa 2713861 ctggtttctt ttcaccctgc catagctgct tgcgccataa tccggtaaca gctcctgcta 2713921 cgcgttctgt ttcaacaggt tttgtgtcct cttccttcgt taggaaaacg gagccaactt 2713981 cgtacagtgc aactgagtca gtctgcctcg caagattgta agaaacagaa tcaagcagat 2714041 ttggaacaag actgtgtctg agaatgcttc tttcttcact cattggaagc gcaagcacag 2714101 tattcagtga tttttcaatc gcaaacgctg tcgctttctt ctcgtttgtc agtgagtaag 2714161 tgatggcttg tgataagcct gcgccttcaa ggaagcgtct gactttacgg cgttttgcct 2714221 gatatggcgt taatccgcct gtagttcccg ctgtctcagg aagcgtagac ggaatgttat 2714281 cgtagccgta cagtcttgcc gcttcttcga ttaaatcctc ttctattgta atgtcaccgc 2714341 gccgtgatgg gacagtcaca acgagaagat catccgcttc accgaccgta aaaccgagac 2714401 gtttataaat gctgatcagt tcttctttac tgatcgtcag gcctagaacg ctgctcactt 2714461 tgtcagcaga tacgtgaatg ttatttgctt cgattgtcag gtgatcttcc tcaaccgttc 2714521 cagcaagcac ctcaccgccg gcatacagat ggatcagctg cgcagcccgt tctgctgcaa 2714581 gacgtacgcg tgccggatca attccttttt caaatcttac gcttgattca cttctcaaac 2714641 caaggtcttt ggaagccttg cgaaccttct gcccgttgaa atacgcagcc tcaagcaaaa 2714701 tggttttcgt atcttcctga acctctgact ctgctcctcc catgacaccg gcaacggcct 2714761 gcgctttcgt tccgtttgta atgacaaggt gatcggcaga cagcttacgt tcttgatcat 2714821 caagtgttac gatcatttca ttctcagctg cttttcttac tacgacttcc ttagagccaa 2714881 atctgtcata atcaaacgca tgaagcggct gtccgtattc caacaggaca aaatttgtga 2714941 tgtcaacgac gttgttgtgc ggacgaatgc ctgcattcat cagctttgtc tgcatccaaa 2715001 gcggtgacgg agcaatcgtg acatttttaa tgatttttgc agtgtacagc gggttcgctt 2715061 cttgatcttc aattttgact gaaatgtaat cagacgcttg ttctgaagca gccgggtaat 2715121 ccgtttgcgg aagctttacc tcagtgtcta aaatcgccgc aacctcgtaa gcaacaccaa 2715181 gcatgttcat ggcatccgcg cggtttggcg ttaaacccag ctcaagaatc gcatcgtcaa 2715241 gctgtaaagc cgctaaggca tcgcttcctg tttcagcgtc attcgggaat acgaaaatgc 2715301 cttctgcata ctccttcgcc acaagtttgc tttcgatacc aagctcctgt aaggaacaga 2715361 tcatgccgtt tgattcttca ccgcgaagct tggctttttt gattttgaaa ttgcccggca 2715421 gcaccgctcc gactgttgca actgcgactt tttgtccctt atccacattc ggcgcgccgc 2715481 aaatgatttg tacaggggct tcagctccga tatccacaag gcacttattc agcttatcag 2715541 cattcgggtg ctgctcgcgc tccagcacat ggccgatgac aacgcctttg atgccttctc 2715601 ctttgtattc aattccttca acctcaatac cggctcttgt aattttttca gcaagaacag 2715661 ccgggtccat gccttttaaa tcaacataat cctctaacca tttataagaa acaaacatcc 2715721 ttgcatcctc ctcttacgcc tgtttaaact gcgaaataaa tctgacatcg tttgtataga 2715781 agtggcggat atcatcaatg ccatatttca gcatcgcgat gcgctcaaca cccattccga 2715841 atgcgaagcc ctgatattcc ttcggatcaa agccagccat tttaagcacg ttcgggtgaa 2715901 ccattccggc accgaggatt tcaatccagc ctgttccttt acatactgag cagccgttcc 2715961 caccgcattt aaagcatgtc acatccactt ctactgaagg ctcagtaaac gggaagaagc 2716021 ttgggcggag tctgatttca cggtcttgcc cgaacatttt tttcgcaaca agttcaagcg 2716081 ttccttttaa atcactcatg ctgatgtttt tgtcaacgac aagcccttca atttgcataa 2716141 attggtgaga gtgcgtcgca tcatcgttat cacggcgata tactttaccc gggcaaatga 2716201 ttttaacggg acctttgcct tcatgctttt ccatcgtacg tgtttggaca ggagaagttt 2716261 gcgttctcat caaagtttcc tctgtgatgt aaaagctgtc ctgcatatcg cgcgctgggt 2716321 gttctttcgg aagattgagc gattcgaagt tgtagtaatc cgtttcaacc tctggccctt 2716381 cctcgactgt gtagcccata ccgataaata aatcttcaat ttcttcaatg acaacagtga 2716441 gcggatggcg gccgccgact gcaacagggt tccccggcag cgtgacgtca attgtctgtc 2716501 ctgcaagctt ctgtttcatt tcctcttctt caagcttctc gtttttgtca gcaatcgcat 2716561 tggcaatacg ctcccttact tcgttcgcga gcgcccccat ttttggacgt tcctcagcag 2716621 aaagcttgcc cattccgcgc agcacttctg taatcggccc tttttttccg agatattgca 2716681 cccgaatatc attgacaacc ttcaatgagc ttgccgcttc tacttgttct aaagcttctt 2716741 gttccagctg ttttagcttt tcttccattt tgcatcctcc ttttatgtaa acaaaccgtc 2716801 atatgtcttt ggaaaataaa aaaaacccgt cccttgtaca agggacgagt tgtggccgcg 2716861 gtaccaccct tatttcagac agactgatgc tgtcgtcagc ttcattgaca taacggaatc 2716921 agattccggt tcacctttac gcgcagtgta cgcggtcccg gcgacaactc aagaggtgaa 2716981 gccaatttcc ggctgcgtta aaaatgctct cagtcagcgg cattttctcc ctggaaagca 2717041 gttgatcaga aattgaggtc ctctgtcacg gtttttgaaa tattatgttc tattatagag 2717101 aaatccaacg cttggcgcaa cactatcctc gcaagtgata cacgaggatg gcagccgcaa 2717161 ccgcaacgtt tagtgattca gcctgtccgt aaagcggcac gtacaggttc aaatccgttt 2717221 tttccagcaa tgcagcatct acccctgcac cttcatttcc tacaatgagc gcaaaggatt 2717281 cagactgagg aatctcctgg taaggcgctc cgttttgcag cgccgtgccg tatactttta 2717341 cgccctctgc cttcaattcg tccacatatg aaggcaggtt tcttctcaca acaggaatat 2717401 ggaagtgaga tccttgagca gatcgcagtg tttttccgtt aaaggcgtcc gccgtgccgt 2717461 caccgagtac aaccgcatcc aaaccggccg catcagccgt tcgaatcatt gtgccaaggt 2717521 ttcccggatc ttgaacagcg tcaatcagca gcaccttgcg tgccgttgcc agcttttctt 2717581 caggcatatg gcacacagcg gcaatctgct gcggcgtttc ggtttcagtc acagctgaaa 2717641 acgcatcttc actcagcata tagcactgga taccagtctc aagatctgaa ggaatcctcg 2717701 tttcatcctt tacaaggatt tctttcacaa tgcccgggct tttcaacgcc tcttcaacga 2717761 ggtgttctcc ctctatcaga aatgtatttg tttttgttcg ttcttttttt gtgtgaagct 2717821 ttttccaatc cttcactttt tggttttttg ccgattctat ttgtttcact gtctatgtgg 2717881 cgctcctttt tttaacatga tgttattata tcgcaagaac agcacataat aaaccaggtg 2717941 cagggttaga atatacgtat tacattttag aaaaaggagc gttttacatg gatcttaatt 2718001 tacgtcatgc cgtcattgcc aatgtcaccg gcaataatca ggagcagctt gagcatacaa 2718061 tcgtagatgc gattcaaagc ggtgaagaaa aaatgcttcc agggctcggc gttttattcg 2718121 aagtcatttg gcagcacgca tccgaaagtg agaaaaacga aatgctgaaa acgcttgaag 2718181 gcggattaaa acccgccgaa taagacatga aaccgggtga cagcgcccgg tttttttctt 2718241 atataataaa aacatgatga gggggaacgc catgttttta cagccgttat tagcgaaaaa 2718301 aattattgct gaagttaaaa aaatgtacga acgtgaagtc attattgtaa acacggacgg 2718361 tcttattatg gcaggcacaa acgatgagcg tgtcggacaa tttcatgagg gagcgcttat 2718421 ctgcgcaaaa gaaagacgca gcgtgattat tacaaaagaa gatgaaacaa ggttaaaagg 2718481 agtgaaagca ggcataaacc tccctgtatt ttttgaccat gatgtgattg ccgtcttcgg 2718541 gctgacaggt gagcctgcag agattcagcc attcggagaa ctgcttcgaa aaatgacaga 2718601 actgttcatt aaggaatcgc ggcacttaga gcaatcccag tggcgtgaga gaatgctgga 2718661 gtcctttatg atcgattggc tgcaattaaa ggagtggtct cccagttttc ttgagaaagc 2718721 tcagcttctt ggtgttgacc tttcttcccg gcgccaaatg attcttattc aggggtatga 2718781 gtggtcacct catgatattg aacaaatggc acgcagctgg aaatcctcgt accctgcgga 2718841 tttgttcatc aggtggggaa atgaacggat tttgattaat catgaagtgc cgcagcatga 2718901 acaaagggat cggcttttgc ggaaaatcct tcacatttgt tcgtttgcca ataccgcaag 2718961 cagccaatat acagcagctg gcgccggaag ggctgtcgca agctccagcc tgacagattc 2719021 atacgagcaa gcggaaaaag cgctggctgt cagccttaag cgaaaaacgc ccatatttga 2719081 agaggatctg aagcttgata tgtgtctgac ggagatcagc ccgggaaccc gaaacgaatt 2719141 tccgcaaaga gtattaggaa aggcgctaga gcatcaggaa cttatgaata cgatacggac 2719201 tttctttcat cacgatttgt ctttgaaaca aaccgctgaa gacatgcata tacacatcaa 2719261 tacattgcgt tatcgtctgg ctaaggctga acagctgacg ggattacgtt ttgaccgtac 2719321 cgaggacgtc gtcacgatgt acgtcgcact ctatttttta gatcaagata caaaatagag 2719381 agagtttcag tttcattttt tgtatgtttc tccatggaag gctttgcttt ttttctttta 2719441 caatagattg aaagcgtttt ttgacagggg gatgggtgaa atgatcacca aggatgtaaa 2719501 ggagcagctg attcaggtct ccggaccaga aaactttgat gactcgaatg ccggccgtct 2719561 cgtctattca tatgatgcga cgcctcagta tcagtctatg cctgatgccg tgattgctcc 2719621 gaggaatact gatgaaatat cacgcatttt aacaatttgc agcgaacatc gagtgccgat 2719681 cgttccaaga ggatcaggga caaacctgtg cggcggcacg tgcccgactg aaggcggact 2719741 tgtgcttctc tttaagcaca tgaaccagat tcttgaaatt gatgaagaaa atttaactgc 2719801 cacagttcag ccgggcgtca ttacgttgga tatgatccgg gcagttgaaa gcaaaggttt 2719861 attttatccg cctgacccga gttctatgaa aatatcaact atcgggggca acatcaatga 2719921 aaattccggc gggctacgcg gattaaaata cggtgtcacc cgcgactatg ttattggact 2719981 ggaggttgtt ctcgcaaatg gtgacatcat ccgcaccggc ggaaaactcg caaaggatgt 2720041 ggccggatac gatctcacac gtctttttgt cggctcagaa ggaacactcg gcattgtgac 2720101 agaggcaatc gtcaaactcg ttccaaagcc ggaaacaaag aagacgctgc ttgcccttta 2720161 tgaaaacatc gatgccgctg ctcaaacggt atcggacatt attgccgcaa aaattatacc 2720221 cgctacgctt gaatttctcg atcagcctac actattggtg attgaggatt atgccaaaat 2720281 cggacttccg acaagcgcaa aagcagttct gttaattgaa caagacgggc catttgaaac 2720341 tgttgaacgg gatatggaaa agattgaggc gatctgcaaa aaaggcgacg ccgtatccgt 2720401 tcagaccgca caaacagagg aggaagcgtt tgccctgact gaagcccggc gttctgcact 2720461 ttctgcccta gcccgcctca aaccgacgac gattttagag gatgcgaccg ttcctcgctc 2720521 agaaatcgcc aatatggtta aagcgattaa tgatattgct gctaaatatg atatttccat 2720581 ctgcaccttt ggtcatgcgg gagacgggaa ccttcacccg acatgcacga cagacataag 2720641 aaataaggat gaaatggaac gtgtcgaaca ggcttttgcc gagatttttg agaaagcgat 2720701 tgaacttggc gggacgataa ccggagagca cggagtcggg gaaatgaaag cgccttactt 2720761 ggaaatgaag ctgaaaaaag aaggcattga tgcgatgaaa gcgttgaaag cggcatttga 2720821 cccccggaac atattaaatc ccggcaaaat gtttgcgaaa gatgccagaa aacgtgtggt 2720881 ggcggaaaga tgacaacaga aaaagaaatg aaacagatcc aaaatgaatt taaagagcgt 2720941 atggatgaag gagagttatt aaattgtatg cgctgcggct tctgtcttcc ttcctgtccg 2721001 acctatatcg aatcgggatt tcaggaaaca cactctccgc gtgggcgcat cgccttaatg 2721061 aaagccgtag ccgacggtat gattgaaccg gatgaagatg tcgaacggtc gctgtcactt 2721121 tgcctcggct gccgcgcctg tgagcctgta tgcccgtctg gcgtgaaata cgggcagctg 2721181 cttgaggaag ccagagatat tatccaccaa aataaaaaac actctcttgg tgaacgtgtc 2721241 atgcgaaaga cggcttttca cgagctgttt ccgcatcaaa accgcatgcg ctcagctgta 2721301 agccttatcg gtttgtatca gcgttcagga ctgcaaaccg ctgtgcgaaa atcaggcatg 2721361 cttcgggtcc tgcctgagca tttgcggacg atggaagctg ttcttcctga tgttccaaaa 2721421 agcaaagaca tgaaacatcg gccgcgtttc ctgccttcca ttggccccat gaaaaaacgg 2721481 gtcgcctttt tttcgggctg cttaatggat acaatgtttt taccgaccaa taacgccaca 2721541 ttgaagcttt tacagctggc aggctgcgac attgtcattc cgcctgaaca ggcttgctgc 2721601 ggggcgcttc atggacacag cggtgaaaaa aacacaggga aagagctcgc gaaacaaaat 2721661 atcgctgctt tcgaagcatt agacgtggat gcagtcatta caaacgcagg aggatgcgga 2721721 gcctttctca ctgaatatga tcatttgctg aaggatgacc ctgagtggtc ggaacgggct 2721781 gccgcttttg ttcaaaagct gaaggatttt tcttctgttt tggttgaact cgatttccat 2721841 caaatggatc tagcactcga gacgcctcag gtcgttacct accaagattc atgtcatcta 2721901 agaaatgtga tgcatacgtc actcgagccc cgccagcttc ttaaaagcat caaaggggcg 2721961 gaattcaaag aaatggagaa agcagacagc tgctgcgggt cagcgggaat ttacaacatc 2722021 gtcgaagttg aaatgtctat gaaaatactg gacagcaaaa tggctgccgt caaagcaacc 2722081 gaagcgatcc tcattgtaac agcaaatcct ggctgcctgc tgcagatgaa gctcggcatt 2722141 gaacgcgaag gactaagcgg taaagtcaga gccgttcacc tggctgattt gctattagaa 2722201 gcagccgggc acaaaacatc atgagaaagc ccaaaacaga cattgttttg ggcttttgtg 2722261 cgttattcca tcggactgca aatttcgata taatgtccat ccggatcagc gatataggcg 2722321 accgtctgcc cccatggttt cactttcggc tccccgataa tcgatacgcc ttgttctctc 2722381 atccttttga tgaccgcttc tacattttca gtaacaaacc cgatttcaaa tgtgtttgaa 2722441 gcagatgtat ccggaatgtc cagcgccgtg atgtctctgg cgctttcccg ggtattaagc 2722501 gccaatatcg tagaccctgt atcaaattcg acatacgtgc cgtgttcagc acgaatcggc 2722561 agtcctaaaa tatcccggta aaaaatgaat agcccgcttg ctgtccgata cgtatagaat 2722621 aagatatttc attgatagat tcattgccaa cccctctcag cattttcaat agtccttcta 2722681 gcccggtata gatgcttcca tccttaagct cggatctttc cacatctgcg cccatttttt 2722741 cacagccgcc acgataatga tgaagcctaa caccagcatg atgatagata atacgccatt 2722801 caatacacta tatcctgctg cttcaggatt gagatacaca ttgcgcacca tccaatagcc 2722861 cgcataattg acagtgacat ataaataggc aagcgggata aggcaagtca gaatgtaccg 2722921 gcgtttatcg gcgattttca gcacgatcgt cgctccgata atcagcccca ctgaagccat 2722981 cagctgatta gaaacgccga agagcgccca aatggaaccg atatctcctg aatacagcaa 2723041 gtacccccac atcaaacagg caagcgcgct ggcaaataca gagcccggaa tccagtctgt 2723101 tttcttcagc ggcttataca cctccccgaa gaagtcctgg atcaaataac gggcgacacg 2723161 tgtgccggcg tcaatcgctg ttaaaataaa gaccgcttca aacataatga caaattggaa 2723221 aaagtatgag gccaaatggc tgaaaaacgg cattccggta aaaatataag tcatccctac 2723281 cgcaagcgtg acggctcccc ctgttcttcc ttctaagtcc aaaccgattt ccccgctcaa 2723341 ttcaggcaaa tgtacgacat tcatgccaag cgtacggaaa acctcaggcg tgctgttaat 2723401 cgcaaagtaa tcagcaggct gtaaagcggt cgctgcaatc agcgccatga taccgacaag 2723461 acactcaaca agcattgcgc caaacgcaac cggcttcata tcactccatt tattcagcat 2723521 tttcggtgtc gttcctgagc cgacaaaggc atggaaccca gagatcgccc cgcaggcgat 2723581 ggttattgag atgaacggcc agacaggtcc tgccagcacc ggccctccgc cttttacgaa 2723641 ttctgtaaac gcagggaacg gaatggacgg attgacgaca aacacaccaa caatcaaagc 2723701 gataaaaaca ccgattttca taaagctgct taaataatca cgcggagcca gaagcagcca 2723761 aacgggaagc gcagccgcaa aaaacgcata aacaggaagc gcgattgcaa gcgttttcgt 2723821 atctagcgtt aaaaagtcac cgagcgcggt agtctgtacc catggaccga taaagactcc 2723881 tgccattaaa aagagaaagc cgaccgttga agcgagcttt aaatttcccg ttttcttata 2723941 aaataagccc acacccatcg caatcggaat cgtaatcccc accgcaaatg ttccccatgg 2724001 attacgttca agcgcatgca agacaaccat cgacaggccc gccattgtga tcgtgatgat 2724061 aaacagcatg gacagtcctg tacaaaatcc tgcaacaggg ccaagctcat ccttcgccac 2724121 ttccgacagc gattttccgt ttttgcgcat cgatgcaaac aacaccacaa tatcatggac 2724181 ggctccccca attaccgccc cgattaacag ccacaataat cccggcaaat agccaaactg 2724241 cgccgccaga attggtccga ccagcggccc ggccgctgcg atcgcggcaa agtggtggcc 2724301 gaacgaaacc catttatttg taggcacata gtctttccca tcctcaagcg catgagcagg 2724361 tgttggcttg tcatcattca ctttgagaac cttcaccatc ataaatgttc cgtataaacg 2724421 ataggcaata gccaaaatac acattgatgc tatcacaatt gtaaccgcat tcattttctc 2724481 ccatcccctt ttctgttttt cataaatata tcataatttc atggtgaaaa gcggtcattt 2724541 tttcctatac aaaaagccgg ctggaatggg ccggctcgtg gcagttgaaa gacaagccgg 2724601 agagaaatct ccggctttgc tattcttatg actgtttttt caggcggatc acattccagg 2724661 aaagcggcgt gaaatgagca gttaagccgt tttcgctgac agacgatgat ccgttggaat 2724721 gcggaacgac attttttctg ttatgctggt ttgttgcttt gatatcctga tgctcaagta 2724781 cgatgtgctc tgcgatttgg taggattcaa agcctctgag cgaaatctcc gtctccatct 2724841 gatcctcagc cttgtttacc gcaaaaatag tgagtgtttc ttcctcttca gagtacacaa 2724901 cagcagcatc aacatatggc acatcagtga aatcagaaca atcgtactta ggagaagaaa 2724961 taagcggttt cagtgactcg ccccttccgt aaacagaagc atgcatgtat ggatagaaaa 2725021 tcggctgtct ccatgcttct ccgccttttt ccgtcatgat cggcgcgatg acattaacaa 2725081 gctgtgcaag acacgcaatt ttcacacggt ctgcgtgctg cagcatcgta atgagcagag 2725141 agccgactaa taaggcatct tcaaaattgt aaatatcctc taaaatcgga cgcgcagtga 2725201 tccacggctc gactttttta tcagcctcat ttgagtggta ccagacgttc cattcatcca 2725261 gagagagatt gatagttttc ttgctgcgtg tttttgcttt tacatagtca caggtcgcag 2725321 cgactgattt gataaaatga tccaaatcca tagaacgtgc caagtagttt ggcagattgt 2725381 tatcccggtt tccgtagtaa gtgtgaagag agatatagtc gacatgctca tacgtatgct 2725441 caagcacctt cgcttcccaa tcgataaagg tcggcatacc gctgtttgag ctgccgcagg 2725501 caacgagttc aattgatggg tcaacccact tcatgacctt tgctgtctct gcggcaagcc 2725561 gtccgtattc atcagctgtt ttgtggccga tctgccatgg tccatccatt tcgtttccta 2725621 agcaccatgt tttgatgcca tacggctgtt catagccatg cgatcttctt aaatcactcc 2725681 agtaagagcc tttcggatgg ttgcaatatt caacgagatt acgggcggca tctatgcctc 2725741 ttgtgccaag gttgacggcc atattgacct cagtgttcac cttttttgcc caagataaaa 2725801 attcatttgt tcccacttca ttggtttctg tcgtttgcca tgccaagtca agccgtctcg 2725861 ggcggttttc gactggtccg acaccgtcct cccagttgta tccggataaa aagtttccgc 2725921 ccggatagcg gatgatggga acctgtaatt ctttgatcag cgactggaca tcttttctaa 2725981 atccatcttc atccgcttca gggtgatcag gctcgtatat gccttcatat accgcacgac 2726041 ccatatgttc gataaacgag ccataaatcc gtttatctac ttcaccgatt ttatattctt 2726101 tgtctacaat cattcgcgct tttttcatca cacgtttcct ccttcattaa cctttgactc 2726161 cccctaccgt caggccggag ataaagtact tttggaaaaa caagaaaatg ataatcaccg 2726221 gcaaaatcgc aaatactgag ccggatataa gcatgtcgta attatttcca taagggctca 2726281 gcaagctgga cagccctatt ggaagcgtaa acatttcttt cgaccgaagc acaatcagcg 2726341 gccacaagaa gttgttccag ctgtttaagg actgaaggat aatcatcgca ccgaaagccg 2726401 gtttcatcag cggtgccata atcctgaaaa agatgccgaa ttccgtacag ccgtccatcc 2726461 ttgcagagtc cagcagatct cttggaaggc caagagcata ttgcctgaaa aagaaaacag 2726521 caacaggtga aacgataaac ggcaatatga cacccgtata tgaatcgatc aagtgcagtc 2726581 cgacagtaag tttaaacaga ggaagcatca tcacttccag cggaaccatc ataataatca 2726641 gcacaagaac aaagatgata tttctgccct taaaatcata aaccgcaagc ccgtacccga 2726701 tcatcgaaga aaaaaacaga gtgagcacag tcgtaaaaag tccgagtaca agactgttaa 2726761 aaaaccattt gaaataaatg ctgccgccat taaacagaaa tgtgtagtta tcaaaactca 2726821 tcacttttgg atcaatatca agattcagcc ccacacgcaa aagctcagat gacggcttta 2726881 atgatcctaa aagcaaacag aaaatcggaa aaagatacaa taggctcagc atcataaaaa 2726941 acagggtcag cgcaattcta taaacgctaa actgaggact gtgccgcaac atttatccct 2727001 cccccttaaa cgagcctgac agctttaatg aaatcaggct gacaacaagg atcacaatca 2727061 aaagcacaat gccgatggcc gctccgtatc ccatttcatt gtaggcaagt ccctgctgat 2727121 acaaatatcc gacaagcgtc agaccaatat tacccgggga attattctgc caaaggacgt 2727181 agctttcctc aaacatcctg aagccgccga tgatgctgat ggtcagcaca tatacggtta 2727241 caggcttgag aaacggcagc gtgatgtgca gaaatttttt cattgtattc gcgccgtcta 2727301 tatcagcggc ttcgtacagc tctttcggca cattttgcaa acctgctaaa aagtaaagga 2727361 tgttgattcc catccatctc catgaagcaa gcagcaccat caaaaacatg ccggtatgtt 2727421 cattgttcat ccagttctga ggtgaaaagc cgagtttaag taggatggaa ttggccagag 2727481 acgtttccat ttctccgaag atcagccgaa aaatgatccc cgcgacaatg gttgaggtca 2727541 atgccgggat aaataatgct gatttaaata tatttctaaa tttgaccagc tttgaattca 2727601 ggaatatggc cagaagcaat ggaacaggaa tcagcacgat cagcgtccaa aaggtgtatt 2727661 ccagcgtatt ccaaagggcg gtatagaacg tcgggttgtt tagcgctgta taattagaca 2727721 atccgacaaa ggacacctct cccggcaaaa ttctttggaa gctcatgatg aagacactaa 2727781 tgatggggta tagaaaaaat acgagaaagg ataaaacgaa tggcgctgta aacagatagg 2727841 gcgccgcttt ttttgaataa aacagatctc gccagcctga ttgtttcgca gctgaaggaa 2727901 cgggatgaac cgttcccgtt ttcacaggtt tcatgagaac ctccccgctt tcactttttg 2727961 aatgggattc tatttctgtt tcagttcacc tgccgctctg tccaaggctt gtttaggcgt 2728021 tttttgctga gatttaagcg cgtcgaacaa tacgcttctg ttgacaaggt ctgaagcctt 2728081 ggcaaaatcc tcatgtaaat aaattggatt gatttcatcc ttgatatcga gcagcacaga 2728141 aaaaatgcct gttccgtttt ggaagtaatc cgtgtatttg tttttctctt tcaattcctt 2728201 ggagctccaa acatcccagc gaagcgggtc aaagccgagt acgctccaga gttttttatt 2728261 tccttcttca gagcccttcg caaaggccaa aaactctttt gctaactcaa catgcttgga 2728321 ttgcttcggt acaacagttg ccgtaccgcc caaacctgcc gagcggtcgc ccccctcttt 2728381 ccatgccggg agcggtctga tggcaatctt ccctttcaga tcaggcatat aatcgataaa 2728441 tcttcccata taccaaatcg gcatgagaac tgaagcagct cctccttggt tcataaagcc 2728501 gtagtattct tcactgtgat gcccgccgcc cggcgcagga atcatcgttt tatcattgat 2728561 catgtctttt aaatattgaa gtgtttttac gttggtgtca ttattgagga tcagcttgcc 2728621 gtttttatca aaatagcctg agttttgctg tgaaatcata gataagaacg ttgcggaatc 2728681 atttgtttcc accgttccca tcggcttccc ggtcactttg cgcactttct gtccggcttt 2728741 atggtaatca tcccatgttt taatatcgtc aggattgacg ccggcttttt tcatcacatc 2728801 catgttataa aacatgaccg ttgtccctac atgtgtatcg agtccgtaaa gctttccgtt 2728861 tttgctgtac aatgtcagcc gcgcctcaac gaatttatcg cgatcctttt caatcagcgg 2728921 agtcaagtcg gcaagcggta tgtcagagcc cttcaaaaag tttgaaaaac gggccaattc 2728981 gacatctgca atatcaggaa cgccttctcc cgctattagg gagatagata agttatcgtg 2729041 catttgtcca tatggataaa cgaccgtatt cagcttaatt ttgcggtcag gatatttttt 2729101 gttccattcc ttcaccattt ccacatagaa ctgctcatga agcccgttaa atgtccaaaa 2729161 ggtcagctca gtttcacccg atttgccgga tgatttttct gctgaacacc cggcaatgac 2729221 taatgtcagc aacatcatga gcacaagaaa acagacagtc atttttttca tctgcgttac 2729281 cccttccatt cgaggtgcgg gctattcata tagaccatgg ttgatcagcg ttttgttttc 2729341 attgatgatt cttaatccgg tgcatcggtc tcttaaggtg tgcgcgtgtc tgaaggcatt 2729401 tttgacggaa tcctgcccga caccgatttc gtcaaaatac gcagggcctc cggctgatct 2729461 cagccaatca gccagcactt ctcctctcgg gagtgtttga taagccgatt ggatggcttc 2729521 ccggcggctt ggtgaaaatt cgttcagccc gtcatcctga gcgagctttc tgtatgtgtc 2729581 agttaataaa acagcggcac agcccacctt tgccccatga agaatctgag gccgtttttt 2729641 ctccattaac tccatttcaa tccaatgtga aatatgatgc tcgccgcctg atgccggtcg 2729701 ggaatgatct aatgccagca tgacaagccc cgatacaagt aaagactcca tcaaaacccg 2729761 tatgccagtt tccgttttca tcgcaatgtc ttctgtgtgt tcaatgcagg cagcaagcgc 2729821 ctcctgaacg atcttagctc ctgcaggcga ataaggctca ccggcaagat gccgggatat 2729881 ttcccaatct gctaaagacg tgattttacc gagcatgtca ccaaagccag ccgccaccat 2729941 tgactgcggt gccgctttta atagatccag atcagcgaac agcgcagatg gggccttcgt 2730001 ttgaatggtt gttttcgtgc cgtataaaat aatcggcgca ccggctgatg taaaaccgtc 2730061 tacagatgga gcagtcggat aagaaataaa cggcaaatct ctttgaaacg ccgcaaagcg 2730121 gacgatatca tgaatcgtgc ccgaaccgac tgcgatcatg acatccgttg gttgtttcgt 2730181 atggatcagc acatgaatga gcgatcgttc atcagctgtc acatctccgg cttcattttc 2730241 tggaatgatc aggcactcgg cctgaaatcc ttcttgattc agtcggtttt ctaaatcaat 2730301 tcctgcaatg cggtgtgtat tcgcgtcgca gacaaggaca atatgttgat tgttttttcg 2730361 ttttacataa tccaaaagcg aatcagctgc ttgcttaccg agaacaattt cttcaacttt 2730421 tataggcaac gtcttttctc cggcgttttc aaaagcacgc tgaacgtcag ctgcgatacg 2730481 attcatatca gaatcccctc ctcagccaat ttggttacat ccttaataga atccagcaca 2730541 taatccggcg tgtacaaacg ctgttcaccc tgtttcgcag aaccagttag cactaaggcg 2730601 cttttcatgc cataaagctt ccccatcgca atgtcagatt caatgctgtc tcctataatc 2730661 atgcattcat gtgcggacag ccccattgct gtacaggcag cctccgccat cagccatgac 2730721 ggttttccga caacaagttc agtcttcgct tgtgcagaag tctcaattgc cccgatcatt 2730781 ccggccacat caatggcatt tccgtcttcg ttcggaaaag agcggtcttt gtttgtagcg 2730841 ataatacgag cgccgccggc agccgcttga aaggcttgat ttaaatcgtc gtacgtgagc 2730901 gtttcatgaa gggagatcac gagccaatcc gcttccttcg gttcgctcgc gttctgcaca 2730961 ccggccagcc tcagctcgtc aaccaagcct tgctccccaa gcacccatac ctttgaaaaa 2731021 cgataatgtt ttttcagaaa agccgctgtc acgcttgatg acagaacaat gtcgtttacg 2731081 tccgtttcaa tccccgcgcc aagaagtttt tttctgcaca tggcacggga gatattcccc 2731141 cggttgctta aaaagacgat tttctttccc attctcctaa gcgttttgat cgcttctctt 2731201 gctccttcga tcaactcatt tcctctgaat acagtaccgt ccaagtcaat cagaatgcca 2731261 gccggtgaca caggcgtatc atgactggcc ataatacgca tttgctccgt gttttcgata 2731321 aaaatgcttt tcatgcagga ctgtattgat tggggttaca tccttgttca gcataatgga 2731381 gtgataggcc atttcggcaa ccgtttctaa tacaactgcg ttatgaatgg catttaaggc 2731441 gtcagtgccc cagcagaacg gtccgtgatt attcacgagc acacccggca cctgttcgta 2731501 attatgatgc tgaaaggttt ccgctatgac ttttcctgta ttcagttcgt agtcatgaat 2731561 gatttcttca tcgtacattt ctcgagtaca tggaatcgca ctgtcaaaat aatcagcatg 2731621 ggtcgtgcct aacggaggga tgtctctgcc cgattgcgcc cagcttgtcg cccattgaga 2731681 atgggtatgg acaattcccc cgatattcgg aaaggcttta tatagataaa catgggtagg 2731741 tgtatctgaa gaaggtttaa gcgagccttc gacgacctct ccatcaaggt tcaaaacaac 2731801 caagtcatcg gctgtcaggt cgctgtattc gactccgcta ggtttgatga caattctttc 2731861 tttttcacgg tcaatgccgc tgacatttcc ccacgtaaag gttaccagct gatgctcttg 2731921 aagcttcagg ttggcagcca gcacttcttt ttttaatgtt tcaagcatgc tccatcaccc 2731981 tttatcaatt ctttttggcg gcagatgaaa attgaagatt tttgatcgtt ttcagacgct 2732041 tcatgacatg gttttctttt ccgaaataat gaaccagctc tttatattca gcgtacaatt 2732101 tttcataaac cgcggcgttt tcggcatttg gcgtataagt tatatctttc agttttccca 2732161 tgttcgccgc tgcctttttg atatcatcgt agccgccttt ttctttgcct gctgcaagcg 2732221 cgccgaaaat ggcagatcct aaggctgggg cttgcggtga accagagatt ttaatgtcca 2732281 tgtttgtcac atccgcataa atctgcatga caaacgggtt tttctcagct attccgccgg 2732341 ctgcgaacag ttcctcaatc ggaacaccgc tttctttgaa tgtttcgata atcatccggg 2732401 ttccgtaagc tgtcgcttca actaacgctc tataaatctc ttcaggcttc gtcagcagtg 2732461 tcatgccaag cagcatccct gttaaatctg catcaacaag agttgaacgg tttccattcc 2732521 accaatctaa agcaagcaag ccgctttcac caggcgcttg atggtttgct ttctcactca 2732581 gcagctcatg aacgccaatg tttttttcct ttgcttcctc ttgataagct ggcgggacac 2732641 atgttttcac aaaccagtca aaatgatcgc cgacacagga ctgcccggct tcatatcccg 2732701 catagcccgg gagaattccg ttgtccacaa cgccgcacat tcctggaacg atatgcacct 2732761 cttcaccaag tagaacatgg cacgtcgagg ttcccataat catcagcatt ttccctggct 2732821 ctgtaatgcc gaccgccggt accgaaacat gagcgtccac attggcaacc gcaacagccg 2732881 ttcccgggag aagccctgtc agctttgcca ttttttcagt cagactgccg gctttttctc 2732941 ctactgaatg aatagaacct gacaatttgt cctttgtaat cgttttcatt gaaggattta 2733001 atttctcaaa gaaatcatct gacggatacc ccgctttttc actccacatc gctttatacc 2733061 ctgcggtaca attgcttcgc ttgagcgagc cgcacagctg gtacacgatc cagtccgcag 2733121 cctcgatgat ccggtcagcc gcttcataaa tgtgaggcgc ttcctcggca atttgcatga 2733181 cctttggaat catccattct gatgaaattt ttcctccgta ccgctgtaaa aaagcctctc 2733241 cttcttcttc cgcgatttga ttgagccgat cagcatgttt ttgggccgca tgatgcttcc 2733301 agagcttcac atagctgtgc ggctcctctt catattcagg cagcatgcat aacggctgcc 2733361 cgctgctgtc aataggaagg atcgtacatg ccgtgaaatc aattccaatc ccgataatgt 2733421 ctttcgggtc aacgcccgtc tgttcgagta aagacggaat ggttgtttcc aagacttcga 2733481 ggtaatcagc agggtgctgc agcgcccagt cacgcggcag cttttgaccc gtttttggaa 2733541 ggacggtatc aatgacagca tgcctgtatt cttttacagc agccgcaagt tcctcccctg 2733601 tttggacatg aacgagcact gctcttcctg ataaagttcc aaaatcaacc cctattgtgt 2733661 aagccatgtg acatccccct ctacttttga agccggtaaa gcgcctcgtt ccattttaac 2733721 tcgtgtttca gtttatgaat tgtcgtatca cgggaaatga gaacactttc gattcccgcc 2733781 atttccgccc aatcaagcat ttgctccgct gtcagttcat aagacaggca ggtatggtgt 2733841 gcaccgccgg ctaaaatcca tgcctccgct gctgttttca atgacggctc cggcttccag 2733901 agaacacggg caaccggtaa attcggcatg tctttttcaa tttcctggcc gttgacttca 2733961 ttcagcacaa ggcggaaacg cccgccaata tcaacaatgc tagcttgaat ggcagaaccg 2734021 ctgatgccgt taaataccaa acgcgcaggg tcctctttgc cgccaatcga aagcgaatga 2734081 acctcgattt tcggctgatc caaagcgaca gtcggacaca cttcaagcat gtgagagccc 2734141 agaatcattt catttcccgg ttcaaaatgg tacgtgtaat cttccatgaa ggaagttctt 2734201 tttcctttag ccatgatttt catcatccgt acaagggccg ctgtcttcca atctccttca 2734261 ccggcaaacc catagccttt ctccatcagg cgctgaacgg caagtcccgg cagctgtttc 2734321 attccgtgca gcacttcaaa cgatgtcgta aacgctgtgt atccgccttg ctcaagaaaa 2734381 gcggttaatc caagttcaat tttcgcctgt tctttaatgg acgctacctt tgcttcgtca 2734441 cgttttgttt cctcactgat cacatatagt ctgtcatact cggcataaag cgtgtcaacc 2734501 tcgtcgtccg taatgcgatc catcacttca acgagatccc cgatgccata tccgtcaacc 2734561 tgccagccaa attgaatatg cgctcccacc ttgtctccgt ccgttaccgc gacatgacgc 2734621 atgttatctc caaatctggc aaccttaata tgtctgcttt catttaatgc agccgccgta 2734681 tccatccact gggacatttc ttttttcact tcttcatcat cccaatagcc ggcaatgact 2734741 tttcggctaa gccccattct cgagttgatg taaccgtact ctcgatcgcc atgcgcggat 2734801 tggttgctgt tcataaaatc catgtcaatc gtaccccacg ggatatcgcg attatattgg 2734861 gtatgcaaat gcataagcgg tttttgataa gaggaaaggc cttctatcca catttttgca 2734921 ggggaaaatg tgtgcatcca tgtaatgatg ccagcacatg tctcactgta ctccgcttct 2734981 cttaacagct ctctaatggt ttccggtgaa gtgacgacgg gcttatgagt gattttatat 2735041 ctggaagaaa tcccgctgag cccctcacaa atgcttttag catgctgatc tacgagttcc 2735101 agcgtctctt ccccgtatag gtgctggctt cctgtcacaa accagaattc ataatccttt 2735161 gtctgaagca tgtaaactgc ccctttctca taaaataaaa cgctttcaaa tacaaaagat 2735221 acgtactaat gatagaaaat aaacctataa ataaatattt gtacgaacaa ttttattata 2735281 gtaattgact attatactgt caatcttttc ttttaaaaaa agccgggggc agagcccggc 2735341 tttttaattc aataggacgg ccagcccgag ctccaattca aatcattgat gagaagcttt 2735401 ggaatgccgt tgtcattggc atcataggca tggcgaacaa gaatgtttcc gttcacaata 2735461 tcctggcctc caggtccttt ccattggtca ttgcccgaat ccaaaatggt gcctccgcct 2735521 tcaagcatgc tttttccgct tttatcaaga taagggcctg taatgctttt ggatcttccg 2735581 taagcaattt tgtacgtact gtttaccccg tcacagcatt tatcaaatga aaccattaaa 2735641 tagtaatatc cattttgata cgtaagagta ggagcttcta aggcacctcc attattcggt 2735701 ctagctgcaa tcgaatagag cgagcctgta ggcttcattg tactcttatc gagcttagtc 2735761 agcttaatgc cgctccaaaa cgagccgaat gcaagccacg ggttgccatc cttatcgaat 2735821 gtcagctccg gatcaatggc gttataatta tttgagcttg tcgaacggat caccaagccc 2735881 tcgtccttcc agccccccga actgatgctt gttgaagatg ccaggccaat ggcagatgta 2735941 ttgcttccaa aagaagaaac ggaataatat agccagtact tgccgttata gtattggatg 2736001 tccggcgccc actggttttg gccataattc ggcacataat tggaccacca cgatagcggt 2736061 gtagtgaaaa tggatttttg tacggtccaa tttttagcgt ctgaagactt caaaacccgc 2736121 agtccccgtt cttcagtaag ccctgttccg agcgcatacc atgagctccc ctctttaatc 2736181 atagtcgggt catgaagcag ctcattggat gcaccccaaa acgctgcctc tgcgggagca 2736241 gcagaagtga atatcaaacc tgcagccaga gctgcactcg aaaagtgtaa gaagcgtttc 2736301 catgtttttt tctttttcaa ttttgttcaa cctcctttat tttagaaagc gcttacaaat 2736361 tagattattt atcctccctt cctgtcaaat cgactgcgta tcgtatatcg tcatgttcag 2736421 gaaattttcg gtatcccctt tattgtagtc actatgctgt aatttgtaca gacaaaaaaa 2736481 tagaatccac ctcaataggc ggattcttcc gtatctttat tggtacgtaa tttcgtcaac 2736541 cgtttttcgg tctaacttct taatgacttc tgtaattaac tttaccgcgt tttcataatc 2736601 atcacgatgc agcatggccg cgtgcgtatg aatgtagcgg gttgcaatgg taatggacag 2736661 cgcaggaacg ccatttgccg tcaaatggat ggcacccgaa tcagttccgc cgccggcaat 2736721 ggcatcaaat tggtacggaa tgccggcttc ctccgcagtg gctacaactg catcgcgcaa 2736781 acctttgtga gagaccatgg atgcatcgta aacgataatc tgcgggcctt tgcccatttt 2736841 gctctgcgct tccttctcgg aaatgccagg cgtgtctcct gctatcccta catcaacacc 2736901 aaacgcaata tcaggctgaa tggtgtgtgc agccgttttc gctcccctca gcccgacttc 2736961 ctcctgcacg gttccgacgc catacactat atttggatga tctgtgtttt gtaagtttct 2737021 taacacatca atagcaatcg cacagccgat gcggttgtcc caggcctttg cgagtaggaa 2737081 tttttcattg ttcatgaccg taaattcaaa atgcggaacg atcatatctc ccggaagtac 2737141 accccactcc aaggcttctt cccggcttga agctccaata tcaataaaca tgtcttttat 2737201 ttccactgat ttttttcttg cttcaggaga caaaatatga ggcggcttag atccgataac 2737261 ccctgtgatt tctccttttt ttgtgacaat ggtgacgcgc tgagcaagca taacctgagc 2737321 ccaccagccg ccaacggttt gaaaacggat aaagccttta tctgtgattt gtgtcaccat 2737381 aaagccgact tcatccaaat gtccggcgat cataattttc gggccgtttt ctgcaccagt 2737441 tttttttgca attaaactgc ccaggcgatc tgttgtcacc tcatcagcaa atggttctat 2737501 gtatgatttc atcacttgcc ttacttctct ttcattgccc ggtatgcctt ttgcatctgt 2737561 taaatctttc agcatggtca atgtttcatc taattttgcc atgttccaaa ccctccttca 2737621 tcagtcctgc attcttatta tacaaaacat ggcgctaacc atacgactat ttcacttgaa 2737681 aatcgggtat atgtttttac agctttcttt tagaaaaagt gaaacctttt tctatgcttt 2737741 tcgtattaca tcagatcatc accataaggg aggtgccttc acacaatgtt tgtcatggtt 2737801 ctaaggatta ttttgcttgc actttttgct tattgtattt atgccgtggt caaatatgtc 2737861 gcgaatccta agagaaggct taagctggcc caatcaaaag aacattttta tattattgat 2737921 gaacaaaaca atacccggaa gaattttcag ctgacgtata aaggcgtgct ttttgaggga 2737981 gaaaagcata ttccttccaa ggatcatccg ctgtttattc acacgatctt tgtctggaca 2738041 gaatctcctg agaagctgaa acatttctct gcaaaagatt ttgagaacat tgaagaaaaa 2738101 gtgctggaac gatatccaaa ttgtaagatt gactgggacc agcccattaa actcgcaaaa 2738161 aaagcagaag agcgttaaac gcttttctgc tttttataaa tcaaacgggc tgtagtaaat 2738221 agcgatgaga atcgcttcta ttaccagaag aagcggtact ccgtacttaa aagaagcgtg 2738281 tttcgtttta tgtctgaagg tttgcatgcc aagccagaca ccgagcgctc caaacacgat 2738341 ggctatcagc cacagccggt cttcagaaat tctccacttg tgctgctgcg ctttgcgttt 2738401 gtcaatgccc atcacccaaa aaccgcacag attaatcaac accaaataag cagcaataat 2738461 catgttgcct catcctttat atagaaaaag ccgctctgct ggagagcggc tctatatgat 2738521 tacttgttta attgagcttt agcagcatca gcaagctgat tgaatgcagt aagatcgttt 2738581 acagcaagat cagcaagcat tttacggttt acttcgatac cagaaagctt aagaccgtgc 2738641 attaaacggc tgtaagaaag gccgttcatg cgagcagctg cgttgatacg agtgatccaa 2738701 agtttacgga aatcacgttt tttctgacga cggtcacgga aagcatagtt tccagatttc 2738761 atgacctgct ggttagctac tttgtataat gtatgttttg aaccgaaata accttttgct 2738821 aatttaagaa cctttttacg acgcttacgt gtaacagttc cgccttttac tcttggcatt 2738881 gaatttccct cctaattgtt ccttatccga ttacttgatg ttagcaagca tttgtttgat 2738941 acgtttgaag tctcctgcgc ttacaacagc actcttgcga agcttacgct tttgcttttg 2739001 agatttgttg gcgaataagt gacttgtgta cgcgtgagaa cgttttaact tcccagaacc 2739061 tgtcttttta aaacgtttag cagatccgcg gtgagttttc atttttggca tgggatttcc 2739121 tccttattgc ttttcgtttt tcggtgcgag cattaagaac atgctgcggc cgtccatttt 2739181 tggttttgtt tcgactgtcg caacctcagc acatgcttcg gagaaacggt ctaatacacg 2739241 ctgaccgatt tctttatgag tgattgcgcg tcctttaaag cggatagaag ctttcacttt 2739301 atcgcctttt tcaaggaatt taatcgcatt gcgcaatttc gtgttaaagt catgctcatc 2739361 gattgtcgga cttaaccgaa cttcttttaa gttaatgatt ttttgattct tgcgtgcttc 2739421 tttttccttt ttctgctgct caaatcggaa cttaccgtag tccatgattc ggcagacagg 2739481 cggttttgca ttcgctgcaa ctaacacaag gtcaagattt gcgcggccgg cgatttcaag 2739541 tgcttcctga cgggacttga ttccaagctg gtcgccattt tgtccgatta aacggacctc 2739601 acgtgcacgg ataccctcat taaccaattg atctttgcta ataatgagcc acctccatag 2739661 tttcttcgaa ttgattcaca actcattttg aatgcatttt gcaggcaaac aaaaagtgtg 2739721 ggcattataa aacacccaca ctacgaacat ctgtatcaat aaaaatgtac ggtcaacctg 2739781 ccaactacat gcatgtgtca atcaggtgag aagcgggtgc ttctgcttgt gatttatatt 2739841 caattcaata actattctac acaataccgg atctttagtc aaggacgact tatccggaac 2739901 aacttttaca ttgtaacatg ggttttctat gagcgcaaga gagaaaaaga aaatctttca 2739961 tccccaccca gaatacaaag aaccaacaat tcccccttat tacgcaattt acaacaaaac 2740021 caccgacagg aagaaatgta aaacaaagtt aatctctgac cgatataagg agcagaaggg 2740081 agcctgacac atgaacaaac tgatacagct tgctttattt ttcacattga tgttaaccgg 2740141 ttgctcgaat agcagcacat cttccgaatc aaaagtcgaa accactgtta agacaacggc 2740201 agcatttcct caaaaggagc tggagaaaga gctaaaaaaa ctaaaacccg tttcattgga 2740261 catgaagttc gagagtccac tcgctaccga gttaggaaag cggaaggcaa aagaggaagc 2740321 tgaaaagcaa agacaaatcg ccgctgagaa aaagcttgaa aaagagcggg aggcgaaacg 2740381 aaagaaacag caggaggaaa aagcggagag acagcgatta gcagagcagc aggctgcaga 2740441 gagacagcga ttagccgaag cggaaagaca agctgaactt gaaagacagc ggcaggcagc 2740501 aatccaaaaa gagcagaaag cgaacgctga gaaaaagcgg caatcgcagg cacaacggca 2740561 gcagactgag gcaccctcat ctaatagtca agatccacca tcttcctcga gtcagacaga 2740621 taaaaccatt caacagccag cttcagagct tcctgatgac gatggttatg gttatgaaga 2740681 acgaaaaaag tggcatgacg atcaagtaga atggggcatt aaacaagggt atatcgatcc 2740741 cgaagacgca ccataaaata aaaaaagcca aggcattcag ccttggctta tcctccgatc 2740801 agctgcacga acacagggat gaccagaacc gttaccactc ctactacgac aacagcaata 2740861 cttgccatcg cagcttcaac ttctcccatc tcaatcccga ccgctacacc aagtgcatgt 2740921 ccggatgttc caagagccaa tcctttagaa atcggatttt tcactttaaa caccttcaag 2740981 aacaatgctc cgagcgcata tacgatgaca gcgttaaaga tgaccgcaaa ggctgtgatg 2741041 tcgctgatgc ccccgatgcc ttttgataaa ggaagcgcaa ttgccgttgt agccgcctgc 2741101 ggaagcatgc ttttcattac ggccgaatcg agatgaatgc ctttagcgag cagataaaca 2741161 atcgtgacag agcagataga gccggcaata atggaggcca tgatttgcca ccagtacttt 2741221 ttaagcttat ctctttgttt gtacaaagga attgcaaatg cgatcgttgc cggttcaaga 2741281 aaaaacttaa tgatctctcc cccgttatta taatccgcgt aggaaaaacc gccgattttt 2741341 aaaaatgcga tccccagcac catggcaaca aacaaaggag tgaaaaggaa gaagcctttc 2741401 gttttcttaa ataaaaaggt gccgatgccg aatgcagcaa gtgatacgac aatcccaaaa 2741461 taaggactca ttgtgctttc catgtgaaga acctcctgtt tcccttaatg gtgaacgagt 2741521 tcgttattgt tctgcgggct ttgcactgtt tttgttttca tgtccgcttc ggttttgcgt 2741581 tttccgctca gcgacagaat cagctgagaa aacaatcccg tagcccccag caaaataatc 2741641 gttgcgagca gaatgacaag aacaatttgc aggccgtatt gctgcatcac accaagcgaa 2741701 ttcataacag atatacctga tggaacaaat aaaaatccga tcagagaggt taaagacgtt 2741761 ccgagcgtct ccacttgttc cagtttaatg actttcaaac ataataggag aaataataag 2741821 accaacccta caaccgatgc cgggataggt attgggacaa tagcggcaat catatttgaa 2741881 accagcataa tgacggcaaa aataaatgct tgtgttaaaa acccgtacac ttttttagca 2741941 ctcattttct tcacctcttt ctctttggta ccctcattat aaataagaat tccctgttat 2742001 aaagcgctta caagataaca tgccgtatag cgggtctgag ttgcagaatc aaatggctga 2742061 aatgcaaaaa gccgcccatc aaatatggag cagctttttc aattccttcg catatgtccg 2742121 gctgaccggt attttcgatc cgtctttcat gatcagatta tacgttgaat taaaccatgg 2742181 ctgaatttct ttaatatatt cagtattcac gacaaagctc cgatggacgc ggataaaatc 2742241 agaatccggc agctttttct caatcacaac gagtgtatcg ctgaccgtat aagaatgatc 2742301 gaaggttttt acattgacat gaccatcttc tgttccggca tagataatgt ccttcgtatc 2742361 cacaatcaca atcgattccc ccacagatag cgcgagcttg tgctggccgg catggctgtt 2742421 ttgctctgtt tctacaatat cccgattgac ttttttatat tttttcagcg tttgctgaat 2742481 tctttcttca tcgaaaggct tggttaaata atcaagagcg tccacctcaa acgctttgag 2742541 cgcatactgg tcatacgctg tcgcaaacac aatagcagga ggatgcttca ttttcttcaa 2742601 tcgctttgcg atatcaaaac cgttttctcc ggataaatca acgtctaaaa acagcaaatc 2742661 aggtttttga tccatcattt ggtcaaaagc ggattcgata ttttccgctt cattgatttc 2742721 catttcatca ttggtccgct taagcaagta agccagttca tcccttgcca gcatctcatc 2742781 atcaactatt aacaccctga gcatgttctt ctccctcttt catctgttgc attggcactt 2742841 gaaaggaaac ctctgtccct ttatgaacct cactgctgat atgcagtgca gcctgctgtc 2742901 cgaataaacc gatcagccgc tgatttaggt tataaagcgc tgtaccggtt ccctccttag 2742961 acggaaacgg tttcttcccc agttccggca agacgtccgg cggaattccg cgtccgttat 2743021 ccgccacctt catatagacg gatgcatcat cagataagac acagactgta accttgcata 2743081 tgtcttgttt tttcggaaac gcgtgccgaa gcgcgttctc gacaagcacc tgcaaaacaa 2743141 acggagggat ttcaatctgc tccagtctgc tgtcgatatt aagctcaatt ttatatttcc 2743201 cgggaaaacg cgcctgttct aatgacaaat aggcgttaag atggttcagc tcctttgaga 2743261 gcggaatcag cagctgtctc gctccttgaa ggtttgaacg aaaataaaca ctgagctgca 2743321 ataggagctt acgggttttt tcaacatctg tacggcataa cgcagaaatc gtgttgatcg 2743381 cattaaataa aaaatgcgga ttcacctgtg cttgaagcgc tttaatttca gcatccttga 2743441 gaagtttgct ttgcagctct gcttccccaa gctcaagctg tgtcgaaaac agcatggcca 2743501 gcccctcggc aagttcctcc tctacctgac tcaggcctgc cgggctttta aagtacattt 2743561 ttaaggtgcc gattgtattg ccgttcgatg tcagcggtag gacaattgca gcgtgcaaag 2743621 ggcattcagc atgcgtgcat tcaatctctt cctgcgaaat cgccttcata atatgccctg 2743681 ttttaatcac ctttttggac aggccggtga tcaagctttt cgatgggatg tggtgatcca 2743741 ttcccgcacc gacatgcgca aggatctttt ctttgtcagt gagagacacc gcatctgttc 2743801 ctgtcagctt atggataata gccgctacac ttttacagga gttttcattt aatccttggc 2743861 ggaaaaatgg aagtgtctga tcagcaatcg taagcactcg atgcgtttcg agagcccttg 2743921 cctgttcttc cttgcgaatg atcgcttgaa taatagacag aaaaataaaa ctgcctgttc 2743981 cattgatgag tatcatcgga attccgatca tgctgacaag ctcccaagcg tcactgaacg 2744041 gctttgccat cagcaaaata atgatcattt gcagtgactc catgccgatt cccacaagag 2744101 cggcgatgcg cggtgtcggc attcgatatc gcttcgtaaa atacctgccg atcaagcctg 2744161 caagaacacc cgctaaaata gatgagacgg cacagcttaa ggccgtgctg ccaccgagtg 2744221 aaaaacgatg caggcccgca agtatgccga tcccagcccc tacaaaagga cctccgagaa 2744281 ggcccccgat ttccacgccc aaaatacggg tattcgcgat agagcccgat ggatctatcg 2744341 taaacaccca gtcattgttt acaatcatat ttctttgaat ttcgatgcct gtataattgc 2744401 tgatgatgct gaaaagagaa aaaatagaaa ttaaaatcgc ttttccttta tagccgtcct 2744461 gattctgaag agcttgtctg aaaagtttcg tatgggcgag aatgaaccct aatataacaa 2744521 taatccccac tctctccagc atcataatca ttaaatgaat cattcatgtc acctgttctt 2744581 tccgttttca ttctagcatg ttttcgtttt gcggctgact gtttttttaa aatcgtctga 2744641 aaacatattt cacaaggctt ttatctattg taaaataaaa catgagcctt ttggcagaaa 2744701 gatttgaatc tgaagcagag gagaagatca tgaaagccgt attttttgat ttagatgata 2744761 cactactttg ggacgaaaaa agcgtcagaa caacatttgc agaaacttgc ttacaggcgg 2744821 agaaaaaata tggccttgcc cctgaggaat tcgaagcagc tgttcgcgaa gcggcgagag 2744881 aattgtacat gtcatatgag acgtatccat atacagtgat gatcggcatt aacccgtttg 2744941 aaggactgtg gtccaatttc tcagagccaa tcagtgaagg ctttcaaaag ctgaacaaga 2745001 ttgtgccgga gtacagaaga aatgcatgga ccaacggact gaaagcgctt gggatcgatg 2745061 atcctgcata tggcgaatac ttgggagagt tttttgcggc agagcgcaga aagcgcccgt 2745121 ttgtatatga tgaaactttt gctgtactcg atcaattaaa aggcaagtat gaattattgc 2745181 ttttgacaaa tggcgatcct agtctgcaaa aggagaagct tgccggcgtg cctgagctcg 2745241 ctccttactt caatgaaatc gtcatctcgg gcgcattcgg caagggcaag ccggatgttt 2745301 caatttttga acactgcctt aagctgatga atattgaaaa agacgatgcc atcatggtcg 2745361 gcgataattt gaatactgat attttaggcg cttcaagagc cggaatcaaa accgtttgga 2745421 tcaaccggac tgataagaaa aacgaaactg acgtaaagcc tgattacatc atcagcagcc 2745481 ttcatgattt gtttcctata ttagagaaat aaaaaaagca tgatctcttc aatgagatca 2745541 tgctttttta ttttattttt tcgcttcagc tactgccttt ttcacaaact catcaagtga 2745601 aatggtttca gagttctgtt ctccgtattt acgcacgttt accgctccgt tttctgcttc 2745661 ttggtcaccg accaccagca tgtacgggat tttttgcatt tgcgcttcac ggattttgta 2745721 gccgattttt tcatcgcggc tgtcgacttc aacacgcagg ccttcacatt gcaggcgttc 2745781 ctgcactttt ttcgcgtagt ctaaatgcac agccggagaa accgggatga cttggaactg 2745841 aaccggtgca agccatgtcg gcagcgcgcc tttgtgttct tcgattaaga aagcaacaaa 2745901 gcgttccatt gttgaaacga cacctctgtg aatgacaacc ggacggtgct gcttgccgtc 2745961 ctcaccgatg tatgtcaggt cgaaacgttc cggcaataag aaatcaagct gaaccgtaga 2746021 cagtgtttct tcttttccga tcgcagtttt cacctgaaca tcaagtttag gtccgtagaa 2746081 tgccgcttca ccttctgctt cgtaatagtc gtggccgatt tcatccattg cctctttcag 2746141 catggattgc gctttgttcc acatttcatc gtcatcaaaa tatttctctg tatcttccgg 2746201 atcgcggtaa gacagacgga atgtgtaatc acttaaaccg aagtcttcat aaacatcctg 2746261 gattaaacgg actgtacgga taaactcatc cttaatttga tccgggcgca caaagatgtg 2746321 tgcatcattt aacgtcattc cgcgtacccg ttgaagtcct gacagcgcac ctgacatttc 2746381 atagcggtgc atcgttccaa gctctgcaat acgaatcgga agctcgcggt aactgtgaat 2746441 gtcttgtttg taaatcatca tatggtgcgg acagttcatc ggacgcaata caagtgtttc 2746501 attgtccatt tccatcggag ggaacatgcc ttcctgataa tgatcccagt gtcctgatgt 2746561 ttcatacagc tctttgctgc ctagcacagg tgtgtatacg tgctcatagc cgaggctgat 2746621 ttctttatcg acaatgtagc gctcgatgac gcggcggatt gttgcgcctt ttggcagcca 2746681 aagcggcagg ccttgtccga ctttttgaga gttcgcgaac agctttaatt ctttgccaag 2746741 ctttctgtgg tcgcgttctt tcgcttcttc tagcatacga agatgctctt caagatcagc 2746801 ttttttgaag aaagctgtac catatacgcg ctgaagcatt tggtttttgc tgtcaccgcg 2746861 ccagtatgcg cctgcaaggc ttaacagctt aaattctttg atttttccgg ttgaaggaac 2746921 atggacgccg cggcacaggt caaagaattc gccttgctca tagatcgaaa cggtttctcc 2746981 ttcaggaatc gcatccaata gttcaagctt caggtcgtcg ccgatttccg caaaacgggc 2747041 tttcgcttct tcacggctga cttcttttcg aacgatcgga aggttcgcat taacgatttt 2747101 tttcatttct ttctcgattt tcggcagatc ctccggtgta atcgcttcgt ccatttctac 2747161 atcgtagtaa aaaccgtttt cgataaccgg accgacgccg aatttaacat ccttgtagat 2747221 gcgtttaatc gcttgagcca gcaagtgagc cgcactgtgg cgcataattt gaagaccttc 2747281 ttctgagcct tctgtaatga tttccactgt accgtcttca ttgatcggcg ttctcaaatc 2747341 gatttctttt ccgttcagtt ttccggctaa tgactttttc tttaatcccg gactgatgga 2747401 tgccgcgata tcttctgttg ttgttccttt cgcaaactcc ttgactgctc catcaggaaa 2747461 tgtgattttt accatatctg acatctttgt cactcctttt tttgcatata aaaaccccgc 2747521 cccctatgaa agggacgagg ttgaataaac ggaatcgtgg ttccaccctt ttttccgcaa 2747581 agccaataca cggcacctgc ggctctaagc tctgtaacgg gagttcccgt cagccattac 2747641 tgttcctttt caagaggttc acagctgaag ttcaaaggcg gtaaagcgaa tggtccttag 2747701 ctgggaagct tgcagccagg gcttccctct ctttgagccg gtatcattcc ttcgtgtcct 2747761 tatcaatacg tgtgtctttc ttaatctcct atgtattata aattgttcaa tccaaaaaat 2747821 caacacgatc gcgtttcctt ttttttaaac cgacagcctt aaatagacag gctgccggcc 2747881 ctcatccttc cgagtgcttc accggtattt ctgcatctgt aaaagcatgc agcgggagca 2747941 tttccactct ctcttgaaat acgttttgaa tggtccttgc catcatgtgc tcgggctggt 2748001 cggtataaag cacgacttca tcaggcgcaa tggaaatcag cggcgcgagc aaatgagaat 2748061 caatatacat aggatgatcc cggacaaatc ttctgtctat gtatttcatt ttttcccgtt 2748121 ccggcacata gcgcagctcc cataatgtaa aggaaccatc atggacaata tgcacttttt 2748181 tgattcgcgg ctgtttggcg tccacatagt ctctgagtgt ttgaataaag ttttgatatt 2748241 cctgttccat cttatattca tcaatcgctg cttctgtaat atctctcagc tgcttatagt 2748301 atgatccaag tcggaaggtc tgaaaggagc gaatgtaaaa tactccttcc tctaaacaga 2748361 tcgtttggag ttcatccaaa attgattgtt tccgtgaaag cttcagcggc tcaaacggaa 2748421 gatcgtctgc ttcaccttca ataatactgt gtgcgagctg aaggatttgc tgctgttcat 2748481 cctggtccgt gaaacaatac gtttcctcaa tcaatgacag catatgctcg tcttctttgc 2748541 attccaaaaa aaatttgacc agaatcggct ccataaaacg ctgaatagga aaagccggat 2748601 tcgctttttc aatcccgatt tttcgtatgc cttcacggac aatgatattg ttccgatcgt 2748661 ccgaatgctg aatgagatgt aaaaaagcgg ctgcatcatg gtcatcttca aagattattt 2748721 caagcatgtt tgtcccccct tacggcatct gttacaagta tatgggggat gtttttaaaa 2748781 tagacgtaaa ggtcattggc aaatcttaat ttgattcttg gaacaagttt tgcattttct 2748841 ttctgaagat gaacggcaat gagataaaca cgatatacaa agcgagcacc ataaagaaag 2748901 cgggcagatt gccagccaaa aagctcgcac ccagcacatt aagcgcaatc gtcccaggga 2748961 tgattcccac agccgttgcg gcaaaatacg gcagcgcttt gacattggaa aggcctgccg 2749021 catagctgac gaaatcaaaa ttgatcggca ggattctcaa aagaaagata tagaaaaatc 2749081 cgttatcctc catttgcttc tgtatggctt caagcctttc gtaatgcccg ttctttttcg 2749141 ccgaaaacaa accagccgca aaaaacgaaa cagctgaagc gcacatcgaa ccgaataacg 2749201 tataaagcgt gccgagaagc gggccaaacg caagtccgcc agctattgaa ataacagaca 2749261 ccggaaataa aacaagtggc ctgacgatgg atatcccgat aaacatcaga ggtgcaaaga 2749321 ctccgaacga caatacccat accctgattt ctttcggcga tacattcaaa tacgttttat 2749381 ttccccaata gagtaaacca gcacctgcaa gcactgccag ccatttgaca gccgtttttc 2749441 gtttcatacc ctcagttcct tcccctttga accacagcaa ttatggatgt cggcggtttt 2749501 ctccgtcaag gcggatcgga gcagccaaat ataatatccg ctccattaat cttgcagctt 2749561 ttacttcttc tttttctccc ctctgcgaat acgtaaaatg atgcttcagc tcgtcaggtg 2749621 agaaattaga agaaaagaac gttggcagct gctgggacat tctgtgctga agcaccgttc 2749681 cgatgacctc atcccttacc cagcttgtca ttgattctgc tccgatgtca tcaagcatta 2749741 atacgggtgt ggtctttacc atattgagct tctcttccaa tgtctggtct tgcagcgaat 2749801 tcttaagctc tctcacaaat tcaggcacat aaacaatcat ggaggaatac tctttttccg 2749861 ccagctcatt ggcaattgca gcgagcataa acgtttttcc taccccaaat ttcccgtata 2749921 aatataatcc tttccctttt cccgtctcat tatagctttt caggaagtct gtaacatgct 2749981 gaaacatcgc gagtctgctt gggtcactga tatcaacttg ctggaacgtc gctccaagaa 2750041 gatcctgctg gatatacatg cttttcataa gagactgttg tttcttctgc tggtcgagct 2750101 tccgtttgac tggacattcg taatactcga tatcaataga cctcccattg acaacaagct 2750161 tcggatggta gccctccaac aaattgttgc agttttcatc ttccgaacaa taggagcaat 2750221 tcttgctttg ttcgatatat tcataaagct tatttaagct cttttcgatc attttttggt 2750281 caatcacttc ttcgttttcc ttcaaaaatg cttgaacatc ttgatctttc atgacttttt 2750341 ccttcatttg ttcaagacgt ttttggaaat ccggcctgcc ggttacgccc tgcagggaac 2750401 ggccgattgg ttccatctat tccttcaccc cgcatctctg tctttaatag gcagagtatt 2750461 ttttcagttt ttgcatttct tccatcatct ttttcttctg ttcttccaaa tcctgcggat 2750521 gcagcttctg ctgtccggat tctgaatcgg acgctgtttc cttttctgtc atccaatcag 2750581 gaagcttttc ttcacgaatc actttttggt ttcgtttcga agactttgtt tttccctcag 2750641 cccattcaag atactggcgg ttttcttcta ttgcgagctt catcgcttcc ctgaccgttt 2750701 tcaccttttt gcgtgcccaa tgcgaagcga ttttttggat atagtttttc gacagcttca 2750761 tgtcggtttt cagcatgaca taataaatta acacatttgt gacgcctggc tcgagcttct 2750821 gttcgaacat aatttcttct atgatcttca gatcagcttt tgacggctct gttccgtcag 2750881 caatgtcctg cagaagcttc ttcggggaaa tcgcctccag caatgcaatc agcttcccat 2750941 ccagagaatc ctcttctgcc ggttgttcgc cttcacgcag atgcaccggc tgtgtttttt 2751001 ccaccaaatc gggcagctgt ccgtttcttt caatttgata ccagtcgctc gccgcttttc 2751061 ttaatgcctc cgtcgtaatg acgtcacgct catcaattgc gctcatcaca acattttgca 2751121 tttgcaaagg gtcaattccg tacagataag aaagcttttt gattgtgtcc cgcacctgct 2751181 gggtcatcgc ttttctcggt atcatcgtct cagaaagtcc cgctaaaaac aaatcaaaat 2751241 caaacacatc ctccgttatg gtgtaggacg gagactgtcc gacagaagta tactcggacc 2751301 cctcggcaag ccttaccgtt tcctccatat cggatgtgag cttccattca ctcggctgca 2751361 gcgattcaaa cgcatgatta aacggacgcg taatgtcctt cgcatcttct gaaatggccg 2751421 ggtgcgtaaa aaattgtttt aattgctgat atttcgtttt tccgacccta ttatacagaa 2751481 aaacattcag cattccgtct tcaaaaaatt catttggtct gagcggcgga aggagttcat 2751541 atataaagag gcgctcctgc cgctcggatt ctttcatata tactttcagc aatccgatgc 2751601 cctcgagctt cccctgttcc tgatggatcg tttttaagtt ggactgtgtc atccccatca 2751661 gctgtctatg tgtggactct ccgccccaca gacggttttg ttcaagctct ccccacaatg 2751721 tcatataaag agagaatgca acagggccga ttaagggctg gtacagttgt gtaataattt 2751781 gtctgtcaat atcctgcagc atcgatctgc ttttaaccac atacgggtct acaggcagta 2751841 catctttcca atagtcagcc atacattctc aaaccttccg aatttgtttc tacctttcat 2751901 tttacaccgt ttcttatatc tatcaaatgc caattttgca catgagaaaa gagctagaag 2751961 aatcctctta gctcttttaa cgctctttct ttattaagtc ttttaattca tcgataaaga 2752021 cgtttatatc tttaaactgc cgatagacgg acgcgaaccg cacatatgcg acttcgtcaa 2752081 tcttagccag ccggtccatg accatttctc cgacgagctc actcttcacc tcggagcagc 2752141 cttgattgcg aagttctttt tcaatatcaa agcacatgtc ttcaagcgtt ttgagtgaaa 2752201 caggcctttt ttcacatgct tttatgaggc cgcgcagcat tttttctctg ctgaattcct 2752261 cacgcacacc ttcttttttc acaacgatga gcggggtttc ctccactttc tcaaaggtcg 2752321 taaaccggta gtggcaggat tcgcactcgc gtcttcggcg aatcgacttt ccgtcatcca 2752381 caggccgtga atcaaggact cgtgttccgt tatgctggca tgaaggacat ttcaataaaa 2752441 tcagctccca actatatcgt tccctgcaat gtattttcgg cagcctccgc cttttaaaaa 2752501 tagatgtgac agcatctgtc gggagagccg ttgttaaatt tgtttctata gcattaggtg 2752561 gtttgtgaaa atctccttct tattttacaa aaaaaatgaa aaaagaaaaa gctgacactc 2752621 tcgtttcttt ataaaaataa aaggagcata agctaaaaag cgcataatgg ctttctagct 2752681 tcagctccct ttgtgttcgc aatttacttt atagtacttt cgcttgcgcc tgtttaattt 2752741 gcacaggccc cattcctctt ggtatttcaa tgttttctct tgtatcagca tgtaatgcct 2752801 ctgcaatgta atcagcagcg acattaggat ctaagtctcc acaagtataa acatcaatgc 2752861 tcgcatatcc gtgctcagga aaactgtgaa tcgttaagtg tgattcagaa ataatcacaa 2752921 ctccgcttac gccttgcggt gcaaatttgt gaaatgcaac ctcgcgcacc tcagcacctg 2752981 attttagagc agcatttaca aacgtttttt caataaaatc catgtcattc agcttatcaa 2753041 aatcgcatcc ccatagctcg gagataacgt gacgccccat tgtttccata gtcatggacc 2753101 ccccttaaca agaattaaaa agtgaaattc caacaactgg gtcggccatt taccacgggg 2753161 gaaagttagt ccggagaggt cctaaccctt taagtaattc cgaaacagtc tcaagcaaga 2753221 agttcacgaa aaatagtata ctgtgtttaa gtctaatttg caaggtgcgt tttttcagaa 2753281 atatgctgtt aagggttttt tctttaaaat gtgtccatga ccttatttta tacagcagac 2753341 ggatgtttca ttcgtgccgc tacatggcgg attagatcaa caactctgca ggagtagccc 2753401 cattcgttgt cataccacgc cagcaccttt actttcctgt cttccattac cattgttgta 2753461 agcccgtcaa tgaccgctga atgcggattc gtattataat cagtcgaaac gagcggttca 2753521 tctgagtaat caagtacacc gtacatcgac gttttggcag cgcgtttaaa tgcctcgttt 2753581 acttcttcag ccgtaacatc cgttttcaga tcaacaacga gatcaaccaa tgagacgttc 2753641 ggaacaggga cacgcaaggc gaggccgtga agttttcctt tcagatgcgg cagcacaagc 2753701 gaaagcgcct ttgccgctcc tgttgttgtt ggaatgatgg attcaccgca agcccgcgcc 2753761 cggcgcaaat ctttgtgcgg gttatcaata tttttttggt cattcgtata cgcatgaact 2753821 gtagtcatca gaccgctctc aatgccaaac tcttcatcca gcacttttac aacaggcgca 2753881 aggcaatttg tcgtgcatga cgcatttgaa ataatgacat ggcgctcagc gtcgaattgg 2753941 tcctcattta cgcccatcac aatggtaacg tcttcatttt ttcccggagc ggtcaaaatc 2754001 actttttttg cacctgcttc tatatggccc atcgctttat ctttagcatt aaacttccct 2754061 gttgcttcga cgactatgtc aatatcatat tcccgccaag gcagctgttt tggatcacgg 2754121 ctgtttaaca aaagcacttt ctttccattt acgatcaggc tatcttcacc agccacaacc 2754181 tctttgtcgt atctgccgtg aattgtgtca tactttatta aatgagccag cgtttctgcg 2754241 gaatagctgg cgttaatggc cactacttga atttgatcgt ctaacatcgc ttttctaaaa 2754301 accattcttc cgattcttcc aaacccgttg atcgctactt ttaccttcat gttggacacc 2754361 ccttatcaat tatgccatcc taatttgtta ctatctaaaa ttagtataac acattaaaac 2754421 aaattcgcca gtacatattg ataaaaatca acgattataa cgctaattta tgatgcatct 2754481 tatgttttct tgcacagaat atcaggcgta agaaccaaaa agcagccagc gctccgcact 2754541 gactgccctc atgctttatg attcctgttt taacttatca ttgagcacac tttcttctag 2754601 cacagaaaat gtatccccgt acactctgtt aatatgattc gctccccaag cacacagcat 2754661 atctaaaatc ccttctaagc tgcggccgta ttcgctgagc tcgtattcca ctttgggagg 2754721 aacttgatta tatacgattc ggttaatgac accgtccgct tccagctcgc gcagctgctg 2754781 agtcagcatt ttttgcgtga tattgggcat taggcgtttt aattcacttg tgcgtttttt 2754841 tccgtgcgtc agatggcata aaatgacgca tttccatttc ccaccgatca cttcaagagt 2754901 cgcttcaaca gaaatgttat attttttctt ctccatacaa tccattctcc tcacaggcac 2754961 caaaaagtga ctatagcact tcaaagtacg tacttttatt tcttaacgat atgtttcata 2755021 atcacatttg ccggctgatt tgaatctgct cttttttatt tatatagctt actcggcaga 2755081 atttcaatca tacaacacat cttacaaagg aggaacatca tgacttcagc caataaaagc 2755141 aatattcctg cactactggc tttggccgta agtgcattcg caatagggac aactgaattt 2755201 atcagtgtcg gccttttgcc gctcattgct gatgacctgg atattcccgt cacgacagca 2755261 ggattgaccg tttcccttta tgcgctcggc gttacatttg gggcacctat attaacttca 2755321 ttgacctcaa gcatgtcacg taagacacta ttgctttgga tcatgtttat ttttattgcc 2755381 ggtaatacga tggcagcaac cgcttcaagc atcgggattt tactagcagc acgtgtgata 2755441 tcggcatttt cgcacggtgt gtttatgtcg atcggttcga caatcgcagc ggatattgtc 2755501 ccggaggata aaagggctag cgcgatttca attatgttta ctggcctcac tgtggcaact 2755561 gtaaccggag ttccttttgg gacatttatc ggccagcagt tcggctggcg tttcgccttt 2755621 atggtcatta tcgccgtcgg aatcattgct ttcattacaa atggcattct tgtaccgtcc 2755681 aaattacgaa aagggacgaa aacaacgatg cgggatcaat tgaagcttgt gacaaacagc 2755741 cggttattgc ttttatttgt cattacagcg cttggatacg gaggaacatt cgttgtgttc 2755801 acgtatctgt ctcccctgct tcaggaagta acaggcttca aagccgggac tgttgcagtg 2755861 attctgctcg gatacggaat agctattgct atcggcaata tgattggcgg aaagctgtca 2755921 aaccgaaatc cgattgccgc tttattctat atgtttatcg tacaggcaat cgttctattc 2755981 gtactgacat ttacagcccc gtatcaagca gcagggctca ttaccattct ctgtatggga 2756041 ttgctggcct ttatgaacgt gcccggcctt caggtgtatg tcgtcatgct ggctgagcgt 2756101 tttgtcccga gtgcagttga cgtcgcatcc gcgatgaata tcgctgcctt taatgcaggg 2756161 atcgcgcttg ggtcatacct tggcggtgtg atcaccgatt caatcggatt gattcatacc 2756221 gcttggatag gcggattaat ggtggtcggt gcagtcattt taacaggctg gagccgcttg 2756281 atggaaaaac gagatcggca ggaagcctga caattttaaa ggaggaaata aacatgacaa 2756341 cacatttaca agcaaaagca acacttcata atggggtaga aatgccttgg ttcggcctcg 2756401 gcgtgttcca agtggaagaa ggatctgaac tggtaaacgc agttaaaact gccattgttc 2756461 acgggtaccg cagtattgat actgcagcaa tctatggaaa tgaagctgga gtcggagaag 2756521 ggattcggga aggcattgaa gaagcaggca tttcaagaga ggatctgttt atcacatcga 2756581 aagtatggaa tgcggattta ggctacgaag aaacactcgc cgcgtttgaa acaagtctgt 2756641 ccaaactcgg tctggattat ttggatctat acctcatcca ctggcctgta gaaggaaagt 2756701 ataaagaagc ttggagagcg cttgaaacgc tgtataaaga aggccgtatc aaagcgattg 2756761 gcgtaagcaa cttccaaatt caccatcttg aagatctgat gacggcagct gaaattaagc 2756821 ctatgattaa ccaagtggaa tttcacccgc gcctcacaca aaaagagttg ataagatact 2756881 gccaaaatca gggcatccag atggaggctt ggtcaccttt aatgcaggga cagctgctgg 2756941 atcaccctgt attggctgac atcgctcaaa catataataa atctgtcgca caaattattt 2757001 tgcgctggga tctgcagcat ggcattataa cgattcctaa atcaacgaag gaacaccgca 2757061 ttaaagaaaa tgcaagcgta tttgactttg aattaacgca ggatgacatg aaccgaatcg 2757121 atgcactgaa tgaaaacttg cgcgtcggtc ctgatccgga caactttgat ttttaatggc 2757181 caaaaaacac cgttcaatat gaacggtgtt ttttgtatta tgcccagctg ttcatgattt 2757241 catcaagctg ccttttggtc tcttcaagcg tgccgctgtt atcaatgact tgatctgctc 2757301 ttgctgtttt ttcctctaag ggcatttgag agcggatacg gctgactgct tcttcttctg 2757361 tcagctgatt gcgcttcatc agacgttcca gttgaagctc ttttgtcaca ctgaccacaa 2757421 taattttatc aaccaatgat tccaatttgc tttcgaacaa tagcgggata tccaatacaa 2757481 caaatgcctc ccgatttgca acggcttcat cacggcgatt gagcatttcc tgcctgactg 2757541 cgggatgaac aattgcattt aaagcgagac gtttttgttc atttgtaaat accagcgctc 2757601 caagcttttt tctatctata tcgccatttg agagcagtat gtcttcaccg aattcgtcaa 2757661 tgatttgccg gtaggccggc atcccttttt ctaccgcttg ttttgcaatg atatctgcat 2757721 ctataactgt tattcctttt tcaatcagca tattggctac cgtgcttttg ccgctagcta 2757781 ttcctcccgt taaaccaatg actaaggtca agagatccac tcctttttac aatttccaga 2757841 gcccaatcgt gattaataga agccccggca aaaacgccat tttatcgatc catttccact 2757901 tagacagaaa atggccggca ttgattccaa ttgatacaaa cagcgagctc atgattgcca 2757961 cggcgatgct catcacaatc ggcgaaaaac cgagaatggc tgcgcctata cctgctccaa 2758021 aggcatcaat cgataaggca aatcccaata agaccgcctc aattccgttg atcacacccg 2758081 atttgtcgat atccgcactc atgggttttc tcaaaatatg aatcacaatt cctaatgacc 2758141 gaacctctag attaagcagt gttttttcat gcaataggta ttctttatct tttgccggtt 2758201 tgaaaaattg atacagaacc cacgcaccga ttccaaccaa tatcaaaccg ccaagcttct 2758261 ccgtcacata tacaggaaaa aacttcgtga gaaagcttcc gatcagcatg gatataaaca 2758321 tgacagcacc ggaacagcag gcgataacca aaatcgcttt aaacggtatt ttcatttttc 2758381 tcaatccgta cgtaaatccg actgaaaaac tgtccaagct gacagccaac gccagcagca 2758441 gtatagaaac catttgcata tccgtttctt cctttctgtt ggtgctcttg tatcagatgt 2758501 gaaatgcccg ggattcatca caatcatata tatgggaaag tgaaaaatcc gtgtttcgaa 2758561 aatggcatcc ttaatccaga gttactgata tatgcaccga cagcttggac aatgaagcat 2758621 tatgctactt ttttgtctgg cactttgcgc aaaaatgcgt gcctcttcct ccaacgacaa 2758681 ttttcgaaat catcgttccg caatttttgc atggctcgtc tttttttccg tacacaaaat 2758741 gctgcagctg gaacattccg atttcccctt gggagttgat atatgaacgg actgtgcttc 2758801 cgcccgcatc aatcgcctcc tgcagagtgt ttttgatttc agcgtgaagg gttttgattg 2758861 ttttatctga taattgattt gcttttgtct cgggatggac acccgctctg aaaagagcct 2758921 catccacata aatgttcccg agtccaacta ccgttttttg atccagtagg gcagttttga 2758981 cagcgcggtt tgttttcgca agccggtctt ttaaatacgc acttgtaaat tcttctgcat 2759041 ccggctccgg ccctaactga gaaagcggga gctcgcccgc ttcttctccc ggtttaaata 2759101 agtgcatggt tccaaatttc cgcacatccc tgtaccggag ctgggttcca tccgtcatcg 2759161 tgaatatgac atgcacgtgt ttatcgtcag gctcctcggc ttgatgaaga ccgtattttc 2759221 cttccattcg aaggtgagaa accataacat aatgatctaa atgaaacagt aaaaactttc 2759281 cccgtcttcc gatggactgt atcgtttctc ctgctagttt tcgcgcaaat tcctccggtt 2759341 cggcaggccg tttgatgata ttcggccatc tgatctctac cgatttgatt gtttttccct 2759401 ttacaagccc ggtcagagtg cgccggaccg tctcaacctc tggtaattcc ggcacatcca 2759461 tcacttccta tctctgttta tttcgcatcg taccaagatg ggcctgatgc aaagtccacc 2759521 tttaacggca catctaatgc aagcgcatgc tccatcactt caggaacaag cttttcaaga 2759581 atttcaattt cttcctttgg cgcctcaaaa atcaattcat cgtgtacttg aagcagaagc 2759641 cttgctttca actgtttttc tttcagcttg gcagccatgt caatcatggc ttttttgata 2759701 atatcagcgg cgcttccttg aatcggcgta ttcatggccg tccgctccgc aaaacttcgg 2759761 atattaaagt tccggctcgt cagctcaggg atgtagcggc ggcgatgcat aagcgttgtt 2759821 acgtatcctt tttgtttcgc ttcctgtact gaatcttcca tgtacgcttt tacgccttgg 2759881 aagctttcca gatagcggtc gataaatgct cccgcttcct tccgggtaat gccgaggttc 2759941 tgtgacagac cgtaatcgct gatcccgtaa acaatgccaa agttgaccgc tttcgcctgg 2760001 cgtctcatcg cagatgtcac ttcatcctta gcgacatgga acacatccat tgccgttttc 2760061 gtgtgaatat ccatatcatt agtaaaagct tcgatcagat tttcatcctt tgaaatatgg 2760121 gcaagcaccc gcagctcgat ttgtgaataa tcggctgcaa aaatgagcca gtctttttca 2760181 gacggcacaa aagcttggcg aattttccgc ccttcctcaa gcctgatcgg aatgttttgc 2760241 aggttcggat cagtcgagct gagacggcca gtttgcgtta aggcctggtt aaatcgcgtg 2760301 tgcactttat gcgaatccgg tctcgtcacc tttaaaagcc cttcgatata tgttgattga 2760361 agcttgccaa tttgtctgta ctgtaaaata tagtcgacaa tatcatgctt gtcagccagc 2760421 ttttcaagca catcggcaga cgtagaatag cctgttttcg ttttctttac gacaggaagg 2760481 ccgatctttt caaataagat gacgcctagc tgtttcggag aattgatgtt aaacggctct 2760541 cccgcaatct catggatttt ttcttcatat tccttcagct tcgcacccag ttcttcaccc 2760601 atccgtttta aacggtcaac atcgaccttg acgccagttg attccatttc gccaagaata 2760661 agcgcaagag gcatttccag ctcttcaaac agttcaagct ggtcgttgtt ttccagctct 2760721 tgaacgagct tttcccgaag gctttgaatc gctaacgctt ttcggccaag gtgctcagac 2760781 agtacgtctt ctgacggcac tgcccgtttt gctccttttc cataaactga ttcatcactt 2760841 gaaacgatat gcaggccgta atccttagcc acactcgcaa cgtcgtcata tgaattgccc 2760901 gggttgatga tataagccgc aaggagcgta tcaaactcgg ctcctttcag ctcaatgccc 2760961 tgccagcgca aagcgacaac ggcccgcttg ctgtcgaaga cccatttctt ctgctcgtca 2761021 ttttccaccc attctttaaa cacctcagac tcaacggcaa tgtctttcgg aatgaaataa 2761081 gctcccgttt catttacgat cgaaaatccg aggatcggct cttcatgata attatcgcca 2761141 atctgttcaa cgacaaatgc ggatggagaa accaatatat cgcttgtcac gtctgtgact 2761201 gttttgacat taatgtcttc caacgattga tcctgttctg cttctgcact gtcttctcca 2761261 agccgttcaa gaagcgtgtt gaagccaaga tctttaaaga tggcaatgac ctgttcacga 2761321 ttaaagcctt gatattccag gccggaaaca gatacctcaa tcggagcatc cgtcataatt 2761381 gtcgcaagct ccttgctcat caatgcctga tccttaaact cctcaagctt ttccttcaat 2761441 ttctttccgc tcacctcgtc aatggactcc agcagctttt caacggaatc aaattgtttt 2761501 aaaagcttaa tcgcagtctt ttctccgacg ccgggcacac ccggaatatt atctgaggaa 2761561 tcgcccatca gacccttcat gtcaatgatt tgttcaggcg taagcccata tttctctttg 2761621 acatgctccg gtgtgtaaaa ttcaacatcg gtaattccct ttctcgtaat ggcaactgtc 2761681 gttttgtccg ttgccagctg ggttaaatcc ttatctcctg agaaaacctt aacttcaaat 2761741 ccgtcttttt cagccgattt ggccagtgtg ccgataatat catccgcttc atattgttcc 2761801 agttcatagc ggctgatctg gtaggcatcc agcagctcgc ggataaacgg catttgttcg 2761861 gaaagctcag gcggggtttt ctgtctgccg cctttatatt ctttaaatgt gccgtgacga 2761921 aatgttgttt tcccggcatc aaacgcaacc agcatgtgcg tcggtttttc atcctcaagc 2761981 attttcatca aaatcatcgc aaagccgtat acagcattcg tatgaacacc tttatcattg 2762041 cttaacagcg gcaatgcaaa aaacgcccgg taagccagac tgtttccgtc tacaagcact 2762101 aatttttttc gttccgtcat tcaatttcct cctaagaagc ctcaggcttc cattcatctc 2762161 ttacatagtc attagctcct cttattttaa caaagttcaa tttgaaagga aaatacgtga 2762221 actataagag aagacacaaa aaaggacggg aacacaaata ggttcccgcc gtcaaaattg 2762281 gctccttgga tgaaggggtt ctactacatc ctaccagcat aggtttaaca gtgcatgaag 2762341 atattgttaa acctttgtaa acattaggcg gacttttcag cggcccgttt cagcgtcacg 2762401 gtaaagacag ttccccgtcc aagctcgctt gtgacatcaa ttttcccttc atgagcctct 2762461 attaaatgct tgacaatcgc taggcccagc ccggttccgc ccgaatttct gcttctgtct 2762521 ttatctacac ggtaaaagcg ttcaaagatg cgcggaattt cttctttctg aattccgatt 2762581 ccagaatcgg caacctcaat ctgaatgtct ttttctctgg gctttacatt gatagccacg 2762641 gagcccccct caggcgtgta ggttaatgca ttgtttacga gattaagaaa tacctgtttc 2762701 agcctgtacg ggtcaccaga tacatattga gggtctttcg ggacattcag gtgcaaggag 2762761 atgcctttct catccgcctt atgcttcaga agcgtttcaa tctcaccaag cattttggcc 2762821 ggctcaaacg tttcgatact gagcgtgaaa ttttgctgct cgatttttga gagatcgagc 2762881 aaatcctgaa ccaaagactg aagcctttcg ctttccttaa gaataataga gagaaattca 2762941 gaaagcgcct ctttgtcttc catcgccccg tccaataacg tctccgtaaa cccttttatg 2763001 gacgtaatcg gtgttttcag ctcatgagaa acattggcca caaaatcctt cctcatctgc 2763061 tctaatttct tcgtttccgt catgtcatgg aaaacgagca caattccttt ccattcatcg 2763121 tccggcccca taatcggaac gccgtccact tcaaaataac gccgttctat tttgatcggc 2763181 agtcttaaca gcttgcattt ctttgtctcc gtcataaaaa tgtcttcgac aagctggatc 2763241 acttcttcat gttcaaatgc atcgtgataa agacggcgca gcatatgatt cggattgata 2763301 tgaaactgct tggcgtaaga cctgtttacg agattaataa agcctcttcc gtcgatcata 2763361 atcagcccgg agccaatgtt ttcaatgact gtcagcagcc gatcccgctg catttcctgc 2763421 gttcgcgtca tttccatcag atcaatggca aggctgttca tcgcatgtcc tagcttatca 2763481 gaacgcctaa tatagccgcc gtacgtccgt gcatcgtagt tgcccttaga gagttctgtg 2763541 gctacatttg tcgctgactc aattgacctt ttataacgtg aggtcatgct ggaataaaaa 2763601 taaacaatga cgataaatgc ggtacaaaga ctggccgtca gcatccccca caattcgcct 2763661 tttaagccgt cgcttttttc agaggcggaa agcagcacat atcctgtttt ttcaccttcg 2763721 cttctaagtg aaagtccgta ataaagcttg ttatctgttg ttgacagaat accctcatgg 2763781 ccagaaacaa gcgcctgcac cttttgggaa tcagccgatc taccgtttga cccatacagc 2763841 accttaccgt ctgtatcgat aacggatgcg ctcacatcaa gcgcgccgcc tgcatcttta 2763901 atgattttct catttgcttg attattcaga ttgccggcat caagaagcga agccaagtat 2763961 tttgcttctt tttcaatgtg ttcctctgct ttcctttgat cagatgtttc aaaaagctgc 2764021 tgtaaaaaca gcccgaggac acaaaacacc agaatcatac agacaacgaa tacagaaaaa 2764081 aggcgcacac ggtatttatt cattcatttt tggctcctcc agtttatacc ccaatcccct 2764141 aatcgtttta atgtagatcg gttttttggt attgttttca attttgtcgc gaagatggct 2764201 gatgtgcaca tcaacaattc tcgtatctcc ggcaaaatca taattccaga ctgcgctcag 2764261 cagcaggtct cttgtcagaa ctctgccttt atgtctgcct aaatagagca gcagttcgaa 2764321 ttctttcggt gtcagttcaa gctgactttc tttaaagtac gcttcataat gatcaggcag 2764381 gattttcaga tcgccgatta cgatctggcc ttccatttca tcgttcttca tctcactaga 2764441 gggcgcagct atttccgaac gccttaaaat cgctttgact ctcgcattta cttcccttgg 2764501 actgaacggc ttggtcatat aatcatcagc accgagctcc agccctaata ctttgtcgaa 2764561 ttcctcatcc ttcgctgtca gcattaaaat gggaaacatc agtttttgct gtctcagctg 2764621 cttgcatact tcgattccgt ccaattttgg aagcatcaca tcaagcacaa tcaaatcagg 2764681 tttctctgtt tccgcttttt tgagtgcttc ttccccatcc gaggcggtaa tgacatcata 2764741 gcctgaccgt tccaaattgt actgtaaaag agtaacaata gattcttcat catccacaac 2764801 taaaattttc ttgttcatgc tgtgcctcca gtattataat tccccgacat cctatttctc 2764861 tattttatgt catcttaaca tgtttcatga ttttatttta gcgaaagcag gacattccga 2764921 caattcgcct tttacatcat ttttaaaaga aataaagacg tttatgatag cgctttcatt 2764981 tatagtaaaa agagaaaggc tgtattaagc aagcctttct ctctttttat taggataata 2765041 ctttcatgac atttttgaca gattcaactg atttattcag ctgcgctctt tcatagtctg 2765101 tcagttcaag ttcaatgatt tgctcaagac cgttgccgcc tacaattgta ggaacaccaa 2765161 ggtagatgcc ttcatagccg tattcccctt caagataagc aattgtagga aggacgcggc 2765221 gctgatcttt caagatcgct tcgaccattt ctgtcagaga agccgcaggc gcataatacg 2765281 cgcttccgtt tccaagaaga ttcacgattt cgcctccgcc ttttctagtg cgctccacaa 2765341 ttgcgtcaat ccgttctttc ggaataagag tttcaagcgg gataccgcca gcataagaat 2765401 aacgcacaag cggaaccata tcgtcaccgt gtccgccgag tacgaaacca gtcacatctt 2765461 tcactgacag gtttaattcc tctgccacaa atgttctgaa tcttgccgta tcaagcacac 2765521 ctgactggcc gattacacgc tctttaggga agcctgattc tttgtacacc gcgtatgtca 2765581 ttgcatcaac aggatttgtc agcaccacaa taatagagtc aggagaatat ttcacgattt 2765641 cctgcgtaac gcttctcata atcttttcgt ttgtagagac cagatcatct ctgctcatac 2765701 caggttttct tgcgataccg gctgtaatga caacaatgtc agagccggct gtatcctcgt 2765761 aattggatgt tcccgtaatt tttgcgtcaa agccttgaac cgggcttgct tcaagcatat 2765821 caagcgcttt tccctttgtc gggttctcca attgcggaat gtcaacaaga acaacgtctg 2765881 ccagctcttt ttgagcgatt aaaaatgcag ttgtagctcc ggtaaaacct gctccgataa 2765941 cagaaacttt tttacgagta tttcccatgt ctctcttctc ctttatggct agttttaggc 2766001 tttttccttg cttagtccat gtttttgatc agttcttctc cgaactctga acatttcact 2766061 tcagtcgccc cgtccattaa tctggcaaaa tcgtaagtta cgactttaga agcgattgtt 2766121 ttttccatag atttgataac caaatcagcc gcttcgttcc atcctaaatg ctcaagaagc 2766181 agaacgcctg aaagaataac tgaagatggg tttactttat caaggcctgc atatttagga 2766241 gccgttccgt gcgtcgcctc gaaaatcgca tgtcctgttt cgtagttgat gttcgctcca 2766301 ggagcaatgc cgattccgcc gacttgcgca gcaagagcat cagaaatgta atctccgttc 2766361 aagttcattg tcgcaacgac atcaaactcg tttggacgcg ttaagatctg ctgaaggaaa 2766421 atgtcagcaa tgctgtcttt gataatgatt tttcctgctg cttccgcttc gctttgcgct 2766481 ttgttggcag cgtcttttcc ttgttcttca gcaatgcggt catattgagc ccatgtgaag 2766541 actttatctc cgtattcttt ttcagcaagt tcatagcccc agtttttgaa ggcgccttct 2766601 gtgaacttca tgatgtttcc tttgtgaaca agtgttacag atttgcggcc atgctcgatc 2766661 gcataatcaa tggcagctct gaccaagcgg cttgttcctt cttctgaaac aggcttaatg 2766721 ccgatacctg atgtctcagg gaaacggatt ttattgacgt ttaactcatt ttgaaggaag 2766781 ctgataagct tttgcacttc ttcagagcct tttgcatact cgatgcctgc gtaaatatct 2766841 tctgtatttt cacggaagat gaccatatca gtatcttcag ggcgttttac cggtgacggc 2766901 actccagtaa agtatcttac aggtcttaag cagacgaata ggtcaagctc ttgtctgagc 2766961 gctacgttca aagaacggat accgccgccg acaggtgtcg ttaacgggcc tttaatcgcg 2767021 atgaaatatt cgcggatcac atctaatgtt tcagcaggga gccactcacc tgttttatta 2767081 taagcctttt ctccggcgta aacttctttc catgtaattt tcttttcgcc tttgtatgct 2767141 ttttctactg ctgcttccaa aaccttcgaa gccgcgttcc aaatatcagg accggttccg 2767201 tctccttcga taaatgggat aatcgggttg tttggtacgt ttaatactcc gttagagact 2767261 gtaatttttt caccttgtgc cacaataaaa acctcccagt atgtaattca tatttagaaa 2767321 acattttatt tttcttatat agaaaataaa atgatttttc ctaacattca atttaaagtg 2767381 taacccaatt ttgatgtctg aacaagaggc taacctcatt gacgcaagcc agcctccaat 2767441 ggttctttag gctctttctt caatcggaac gaatttttgt ttgtcagggc ctgtgtaatc 2767501 tgcccgcggg cggatcagac ggttgttgtc atactgctca agaatatgag cgagccagcc 2767561 ggacattctg cttacagcaa aaatcggtgt aaacaaatca tggtcaatac cgaggctgtg 2767621 atatacagaa gccgaataga aatcaacgtt aggcggaagc tttttctctg atgtgacgat 2767681 gtcttctata cgaatcgaca tctcatacca tttgctttcg cctgtcaggt tggtcaggcg 2767741 cttgctcatt tctttcagat gcttcgcgcg cggatcacca tgcttataca cacggtggcc 2767801 gaatcccatg attttttctt tcttttcaag tttagcgcgg atgtacggct cagcgttttc 2767861 cacttcaccg atttctgtca gcattttcat aacgccttca ttcgctccgc cgtgaagagg 2767921 ccctttcagc gcgccgattg ctgcagtaat gcctgaatag atgtcagaaa gtgttgcgac 2767981 gcagaccctc gctgtgaacg ttgacgcgtt cagctcatgg tcagcatgta aaatcaatgc 2768041 tttgttgaag gcttcaactt caattggtga aggctcttca ccgtttaatg tgtaaagaaa 2768101 attctccgca ataccgtaat cttctctcgg ttcaacaggc tcaagaccct tgcgaattct 2768161 ggaaaacgct gcaaccaggc caggcacctt tgcctgaagg cggatcgcct ttctgtagtt 2768221 ggcttccggg ttcatggtat cagcctcgct gtcaagcagg cctagtaatg aaattgctgt 2768281 ccgaagagca gccatgggat gaacattttc gagggaataa gatttgaagt gctcaataat 2768341 ttcttgcgga acggcagctt cctttgcaag ctgctgcttt aactcttcaa gctctttttt 2768401 gtttggcagc cttagatgcc aaagcaagta gatgatttct tcaaaacttg cattctctgt 2768461 caaatcatcg atatcatacc ccacatatgt aagggtatca tcaataatag aactaacaga 2768521 tgatgttgtt gctacaaccc cttcaagacc gcgtgtcgct gtcatatata acatctcctt 2768581 ttcaataaat ttccccttta agagtgttgt aaaaacatga ggcttactta aaaagcacga 2768641 tgcaagtatt tctctccccc aaaaagaaaa tgcttacatt ttactggctg ctggaactaa 2768701 aaccctttgc ttttgaaaga acataacaaa tttttataag cttatttaag tttaagccta 2768761 ttctcattat aaacaataat cagacatttg ttaaatgttt acctataatt ttttttttcc 2768821 attctgtgat ttccccgaaa aaacgccttt atttgcgggt ttttgcataa aaaaaagcgg 2768881 ctttaaggcc gctttttttt atgaagtgaa cagttttacg atctgcatgg ctaaataagc 2768941 aatccccgct ccgatcagcg gccccaccgc aactcctcca aaaagcgcga ctgcaagaat 2769001 ggtcccgatc acgagagcag ttgtaatatg cggatcattt tcaagcaggg tcaggccgtt 2769061 ttttgcaatc agcgccactg cgatccccgc tccaagggcg atccatgcgt aggaagaccg 2769121 cattgcttct ccaagctgct taaatccgat ttctcccgtg gcaatcggga caagaacggc 2769181 gatggtaata atggtcacac cccagttaat gccttttgac tggatggtcg gaaataattt 2769241 ctgatcaagc ccaacgattt tgatgatcaa aaggacggat acagcaaaga gcaatgattg 2769301 gttttttgcg ataagtgcga tagccaagag taaaattaaa aataaattcg cttgtgtaaa 2769361 cacatgccat ccctccttta agatgaatgt attcatattc agccgcagcg tgaatacata 2769421 taaaaaatag gacatgctga cgagaggagg accgtttttg tgaatcaatc ttatatcact 2769481 atttttttca gaaccctctt tgtcatatca atgaccgcag ggtcgatagc tgcggcctat 2769541 tattcgtttc cgttaactta tccgttcctg atcgccctta ttctatcttc agtgattcat 2769601 cctgttgtcg attatttgga caaagtgaca ggattccccc gaacgataaa tgttctgggc 2769661 gttcttgctt tttttctgct cgcagccttc ggcgtgctca ccattctggt agccgaaatc 2769721 gtaacgggaa cagcctatct agcaaaaacg ctgcctccgc atatcagcac gtttatttca 2769781 tattgcgaaa aattgtttac cactcatatt cagccgctct ataacgagtt aactcttttg 2769841 tttcaagaat tggaaacgaa ccagcaggct tccatcgtca ctcatatcca gacactcggt 2769901 gattctgccg ctaaaaatgc cgggctcctg ctgtcccaca ttctagagat gatcccgaga 2769961 tttttcgctc ttcttcccaa tacggcggcg gttctgattt tttctcttct ggcaaccttt 2770021 tttatgacaa aggattggca taagctgaaa gccatgcttg ttttaattct gccggatcgt 2770081 gtgacagcta acagcaaagc aatcagcagc gaattaaaaa aagcaatgac tggttttatc 2770141 aaagcacaag ccgtcctcgt tttcatcacg atggtgattg tatttatcgg cctttctctc 2770201 ttaaaggttg aacacgccgc aacaattgct tttttaatcg ggcttgtaga tcttctccct 2770261 tacttaggtg ccggctccgt atttgtgccc tggattttgt atttatcgat tacgggccag 2770321 ctgccccaag caatcggaat tggtatcctg tacctcgtcg ttcttattca gcggcagctg 2770381 acagagccca agatactaag taaatctatc gggatcgatc cgctggcaac actcatcgcc 2770441 ctgtttgccg gctttaaatt attcgggttt ttaggactga ttgcgggacc ggctgtactc 2770501 gtcatcatcc aagctttcat cacaacaggc gcattaaaag aaatatggtc ctatatcacc 2770561 gttcagcaaa aataaaacgg cagccgtttt ttcatggctg ccgtttttta tttgatgatg 2770621 atccgcttat tcttcgacat tcctctcagc catttgaaca gaatcggctt acaccagccg 2770681 cgggtaaacg ggataagaag acaggcgccg gccaaatctg ataaaaagcc cggaagcatc 2770741 agcaatagac cgccaatgaa aatgcacaga ccgtcagcaa tcgcttctcc cggcattttg 2770801 ccatattgaa gatcacgctg aaccttataa tacacttcgg ttccttgttt ttttgcagct 2770861 gctgcgccga taatgccagt cagaatcatg aatagaactg tcggcaaaat accaatcaga 2770921 tttcctaaaa ataggaatat accgatttct attgccggaa acacaataaa aagcaaaaac 2770981 aaaaatctca tatccaagcc ccccacacgt gtaacacgtt ctgttcaaca aaaggcatga 2771041 taaagagaaa aggaagggat tccccttcca ttttcacctg taattaaaga acgctcgcac 2771101 ggccttgata gactgcgcct ctggaagcgt caactgtaat atcctggcca tctgtcaaaa 2771161 tagatgtcgc attttccaga cccacgataa ccgggatgcc aaggcttaat ccgactaccg 2771221 cagcatggct agtcaaaccg ccttcttctg taataagagc agacgctttt tcaagggatg 2771281 caatcatatc acggtcagtg cttttggtaa caagtaccgc accgtcagtc attttttgct 2771341 cagcttcttt tgcattttgt gcaacgacaa ccggaccgta agctgatttg cgtccaatgc 2771401 cttggccttt agcgatgata tcgccgacag tatgaacctt cattaagttc gtagtgccgg 2771461 actcaccgac agtgccagct gtaataacga taagatcgcc gtgttttaca attccgctgt 2771521 tcaatgattt ttggacagca tcctcaagca tctcatctgt tgagctcgca ttttggccgc 2771581 tttccgcgaa tacgccagat acgagggcaa gctttctgga aatagagtca tttacagtaa 2771641 ccgcaacaat cggagcctgc ggacggtatt ttgcaatcat acgtgctgta tggccgcttt 2771701 ctgtcggcgt tacgatcgca gcagcattca ggttaatcgc cgtatgtgcg acagattgtc 2771761 caattgcgtc tgtaattgtc atgcccactt ggtctctgcg ttttgagaga atttctttat 2771821 aatttaatgc ttcttcagaa cgggacgcga tgttatgcat tgtttgaact gcttcaaccg 2771881 ggtaacttcc ggcagcagtt tcaccagaaa gcatgatcgc atctgttccg tcgaagatcg 2771941 cgtttgcaac gtcacttgct tccgcacgag tcggacgcgg gttgcgctgc atgctgtcaa 2772001 gcatttgtgt cgctgtaata acaggtttgc ccagcgcgtt gcattttttg atcagttctt 2772061 tttgcacaag cggcacttct tcagctggaa tttccacacc taagtctccg cgtgcaacca 2772121 ttaagccgtc agacacttcg agaatcgcat cgatgttgtc aacgccctct tggttttcga 2772181 ttttagggat gatttgaata tcctgagcgt tgtgctcttc aagaagctca cggatttcga 2772241 gcacatccgt agaacgtcga atgaaagatg gtgcgatgaa gtctactcct tgctcaatac 2772301 cgaaaacgat gtctcgcgca tccttttcag taatccccgg aagattgaca cttacgcccg 2772361 gtacgttaac acctttttta tttttgagtg ttccgttgtt taatactttt gttttgattt 2772421 cgcgtttagc ggcatctaca tcaagtacct caagaccgat aaggccgtca tctaacagaa 2772481 tcgttgaacc ttgttcaacg tcatggacta aaccttcata tgtcactgaa attttatctg 2772541 ttgttcctac aacctcgtcc attgaaataa tgagctcttt gcctgtttca agctcaatac 2772601 cgccgttttc cattgtatgt gtgcggattt caggaccttt tgtatcaagc agaattccaa 2772661 cgttcttgcc aagtttttta cttgcttcgc ggatattttt aattcttgca ccgtgctcct 2772721 caaaatctcc gtgagaaaag tttaatcgag ccacgttcat tcctgactcc attaatttcg 2772781 taagcatttc aatactttca cttgccggac cgatggtaca aacaatttta gtttttctca 2772841 tttggttcac ttccttctga aatcttcagc cttcagctgt acattagata gacagttctt 2772901 ttgaaagctg atacatgttt tgctcaactg tgtgttttgt ctcaagtatt tctataatat 2772961 catggtctac aagcttattg ttttgtatac ctacacagcg tccgcctttt ccttcaagca 2773021 gcagttcaac tgcatatgcg ccgagacggc ttgccaacac acggtcagca gcactcggag 2773081 aacctccgcg ctggatatgg cccaatacag ataccctagt ttcaagattt gtttcttctt 2773141 caatgcgttt cccgaattca acaccgctgc ctacaccttc ggcaacaata ataatactgt 2773201 gcttcttgcc gcgttcgtgg ccgcgtttta agcgggcaat gatttcgtgc atgtcatagt 2773261 ctgcctcagg gattaagatc gattctgcgc cccctgcaag accggcccac aatgcgatat 2773321 cgccggcatg acggcccatt acttcgatta catatgtacg ttcatgagaa gtcgctgtat 2773381 cgcgaatctt atcaattgcg tcaattactg tatttaaagc tgtatcgaaa ccgattgtaa 2773441 aatcagtgcc cggaatgtca ttatcaattg tacccggtac acctacacat ggaaacccgt 2773501 gttccgttaa ttttttcgca cccatatagg aaccgtctcc accgataaca acaaggcctt 2773561 caataccaag cttcttcaag tttgctatcc ctttttcacg gccttcaact gttttgaatt 2773621 caggacatct cgccgtataa agcttagtcc ctccacgatg tataatatcg cctactgatc 2773681 cgagttcaag cttttcaatc tttccgctga tcaatcccgc gtatccgttg taaataccgt 2773741 aaacttcaac gtcatgatag atcgcttttc tgactactgc gcgaactgct gcgttcattc 2773801 ccggggaatc cccgccgctc gttaataccc ctattcgttt cattctccat tcacctcagc 2773861 aacatatatg attaaacata acatgatcat tgccctaaaa acaatgaaaa gggatctcca 2773921 tcctccctat gaaaccttac ctattataca attaaataaa ttgtttttaa ataaaattta 2773981 aggaatgtca caaaaaataa acgtgagcca aaggcttcac gtttatttag tttaccccga 2774041 tatattgatc ttcaaccgag actttgccaa ttgctttata tttttcataa cgctgctgaa 2774101 ctaattcttc ttcgctcagc ttcagtaaag tttttaacga ttgtttaagg gtttcgtcca 2774161 tatagcttgc ctgcagcttc acatcatggt gcgctccgcc ttttacttct ttaatcatat 2774221 gatctataat acctaattct tttaaatccg gcgcagtgat tttcattgtt tctgctgctt 2774281 ttttagcaag actggagtcc ttccataaaa gtgccgcggc accttccgga gaaataacag 2774341 aataagtaga gttttccagc atatgcaagt gattgcctac acccagacca agggctccgc 2774401 cgcttccgcc ttcaccaatg acgatgcaga taacaggcac tcgaaggccg gccatctcaa 2774461 acaggttttt ggcaatagct tcactttgtc ctctttcttc agctgctcgt ccagggtatg 2774521 cccccttcgt atcaataaaa cagataattg gtctgttaaa tttgtcagcc tgtttcatca 2774581 gacgaagcgc ttttctgtag ccttctggat gcggcatccc aaaattgcgg actaggtttt 2774641 ccttcgtgtc tttgccgcgc tgatgcccga ttaccgttac agggaggccg tggaacttcg 2774701 caatcccgcc gacaatggct tcatcgtccc cgtacgctct gtctccgtga cattcaaaaa 2774761 agtcggtaaa caggtgttcg atataatcaa gagttgtcgg acggtccgcc agacgcgcga 2774821 tttgaacccg gtcccacggc ttcaaatttt tgtaaatatc atcctgaagc ttagcgagac 2774881 ggtcttcgag ccgttcgatt tccgcactta gatccatatc ggaatcttgg gtgaattttt 2774941 ttagttcggc gattttggtt tgcagttcaa tcaccggttt ttcaaattct aatcttggag 2775001 ccactcaatg tcacctcctg tttgatgcat atccagcaga ttttctaacg tttttttcat 2775061 atcgtcgcga tgaataaccg catcaagctg tccatgtttt aataaaaact cagccgtttg 2775121 gaagtcctca ggcagttttt ctcctattgt ctgttcaata atccgtcttc cggcaaaacc 2775181 gatcagcgcg ccaggctcag cgaaattgta atcgccaagg gatgcaaagc ttgctgatac 2775241 gcccccggta gtcggatgcg tcattactga aataataaga ccctgttctt cactgaacag 2775301 ttttaacgca gagcttgtct ttgccatctg catcaaactt aatacgcctt cctgcattct 2775361 agcaccgcct gaagccgtaa aaataataaa cggaacttta tcagcttttg ctttttcaat 2775421 cgcaagcgtg attttttcac cgacgactga acccatgctg cccattctga atgaagagtc 2775481 catgacggcg acaacagccg ggtgtccgcc gatggtgccc ttgcctgtca caacagcctc 2775541 gtttaaggat gttttctcgc gatctttttc aagcttttcc agatatcccg ggaaaccaag 2775601 cggattttcc gagagcattc cctgattaaa ttcctcaaag gattgttcat ccatcaagct 2775661 ttcgatacgc tgttttgcgt tcattgggaa atgataatcg cagttcatgc atacccgcat 2775721 atttttatcc aactctttag tgagcatgat ttttttacac ttaggacatt ttgtcataat 2775781 gccttccgga acatcgtgct tcgcttgatc agacggtacg gaagcatact ttttcttttt 2775841 cgtgaatata tcctttaaca aatgattacc tcccttttgt gaagggttct cttcaccgca 2775901 tgtcatcaaa cagatagact tgctaataac tttaccgaaa ctattgtact ttttttgtca 2775961 aacgctgtca tcctcaattc gacaactttt tattcgatga cgtgctcgga aaggcttgta 2776021 tgaaatcaga taaggtgttg aaacgacaag gttgacagcg cattcaaaaa taatgttaaa 2776081 cccggctgaa atttttttaa ggctaacccc ctaaaaaaat ttcagccgtc agtttaactt 2776141 gagaacagcg cgccggtctc cgccaacgcg ctgccatttt tggaatgaat taaaattatt 2776201 caccaataat cgtaagtttt cttgtttttt ctgcgacttc ctcagggtca acagtgattc 2776261 ttgcaacacc tgtttccatc gcagcttttg ccacagcctt cgcaacagca ggcgcaacac 2776321 gtttatcaaa cggtgcaggg atgacatagt ctgcgctaag ctcatcttct gaaaccagtg 2776381 aagcaatggc ttcaaccgct gcgattttca tttcctcgtt aatatgagtg gcacgcacat 2776441 caagcgctcc gcggaaaata ccagggaatg caagaacatt gtttacttgg ttcgggaagt 2776501 cagaacggcc agttccgaca acgcttgctc cggcttcacg cgcatcttcc ggcatgattt 2776561 ccggatttgg atttgccatt gcaaagataa tcggatcttt tgccatgctt tgaaccattt 2776621 cttttgttaa cgcgcctgct acagagacac cgataaatac gtcagcatca acgataacat 2776681 ctttcagaga accgtctttg cgatcttggt tcgtgaactt cgccacttca tttttgacat 2776741 cgttcatgcc gttcgggcgc ccttcataaa tggccccttt ggaatcgcac atcacaatgt 2776801 cgcgaacgcc ataatgatga agaagcttga taatcgcaat gccagccgca cccgcgccgt 2776861 ttgcgacaac tttaatggat gacatggatt ttccagacag tttcagcgcg ttcacaagac 2776921 ctgctacggt tacaatggca gtaccgtgct gatcatcatg gaaaaccggg atgtttgttt 2776981 cttttttgag gcgctcttca atgataaagc agtttggcgc tgcaatatct tcaaggttga 2777041 cgccgccaaa tgtcggttcc agcaatttta cagtttcaac gattttatca acatcgtttg 2777101 tgtttaaagc aatcgggaac gcatctacgc ccgcaaagct tttgaaaaga actgctttcc 2777161 cttccataac aggaagcgcc gcttcagggc cgatgtttcc aaggccaagc acagctgtac 2777221 cgtcagttac aactgctacc atgttcccct tcattgtata atcatatact ttgttaatgt 2777281 cttcatgaat atccttacac ggttctgcaa cacccggaga atacgcgagg cttaaatctt 2777341 tcgcatttct gacctctact tttgatttag actccagttt cccctggttg actttatgca 2777401 ggtgtaatgc ttcttctctt aatgacattc tcctaaacac tccttatgga tattttttga 2777461 ttcgtatact gctgcgttga ttgctgcatt ctgcggagta aatctatctg aatatttaaa 2777521 caggatcaca taattgctcc aattgtataa caaaaagcga atcgttacca ctgttttaaa 2777581 acgacgtttt tttgacccaa cagctctttt aagcgatata acacctggtg atctgcattg 2777641 atatggaacg actcaggtag cttaatcgtc tgtttttgcc tttcataata gagataaacg 2777701 cctgtttccc ctttatgctc cagcaaaatg cgcttaatct ttgccaggat ctcctggctg 2777761 tgctgactgc tttctatttt tatataaacc gatggcgctt tttctgcatc catatcttct 2777821 aataattctg cccgggacat gatgaattgg atcttatctt gtctaacttc acatttcccc 2777881 gcagtgaaca aaagagcgcc ttctcttaaa acgggagaaa gctgtctgaa ttgttcaggg 2777941 aagactacgg cttccatctc gccggtttca tcactgagcg ttaaaaacgc catgttttga 2778001 cctgttttcg tccgaatcgt tttgatcttc gacagcagaa cgcctagtga aagctgcctt 2778061 ttgactgccc gctgagcctg cagaatggag actgctcctt gcgcagtgag ctgttttcgg 2778121 aaggcggaga ggggatgatt tgaaaaataa atgccaagcg tttccttttc aaacgcaagt 2778181 aaatccacca gaggaagctc ctccgtctcc acatacttcg gcttaattga aaacgattca 2778241 tctaaaaaca atcccatttg gtcatcgtcc gcggcgaata gctcagcatg ttccaaagca 2778301 acatcaatgg atgcgagcag cgtggcccgg ttttggccga attcgtccat cgcaccagaa 2778361 aagataagtg cttcaagcat tttgcgattt acgctttttg acggcacgcg aaagcagaaa 2778421 tcgaaaagat cttcaaatgg tttctctttt cttgctttat atatatcttt gactgctgag 2778481 acgcctacac tttttatcgc gcggaggctg tatctgacag atccgttttc aactgtaaac 2778541 ggaaaactgc ttttattcac tgacggagga aggatacgaa tcccgctccc ctttgcttcg 2778601 taaagatatt gagagatttt atcctcattg ccaatgacgc ttgtcagcaa tccgcacata 2778661 aaatataacg gataatgagc tttcaaatac gcaagctggc acccgatcat gctgtatgcc 2778721 accgcatggc ttctgttaaa gccatagttt gcgaatttga cgattaaatc gtagacctca 2778781 tttgcagtgt ctacagaata ctcctttttt aagcaccctt caacaaaatg gcttcgctct 2778841 ctgtccagga tttctttttt ctttttgctg accgcccttc tcaataggtc cgcttcgcct 2778901 aaagaaaacc ccgccatacg ggaagcaatc atcataattt gttcctgata cacaatgacg 2778961 ccatatgtat cttccaaaat gctccttaaa tcttcatgag gatagtgaac aggcgcccga 2779021 ccgtgtttac ggtcgataaa taacggaata ttttccatcg gacccggccg gtacagtgca 2779081 ttgaccgcca caatatcttc taggcccgaa ggtttcagcc gtttcaagac gcttctcatc 2779141 cctgcagatt caagctggaa aatgcctgtc gtatcccctt ttgacagcaa ggagaacgtt 2779201 ttgtcatcgc tgtaggaaat acttgaaagg tctattttaa tattttcttc tttttcaatc 2779261 attgaagtga tggattcaat aagtgtcaga ttcctcaaac ctaagaaatc catttttaaa 2779321 aggcccaagt cttcaagatg gtccatcgcg tattgcgtta aatagatccc ttcatgccct 2779381 tcttgaagcg gaacaacatc tgttaacggt tcttcactca ggacaacgcc cgctgcgtgg 2779441 gttgatgcat gccttggcag cccttctatt ttccgggcaa ttgaatagac ttgctgaagc 2779501 aggcttgact cccgaagccg cttatccagc tgcggtgact gctgtctcgc ttcatccagc 2779561 gtcattcccg gtcttgaagg aatgagtttt gcaagctgat ctgcctcctt cgggctgacg 2779621 ccgaatactc tgccgacgtc ccggagcgcc gcctttgccg caagtgttcc aaaggtgata 2779681 atctgtgcga cgtgcattgc accgtatttc tgctgaacat attgaatgac ttcatccctt 2779741 ctagtatcgg gaaagtcaat atcaatatcc ggcatgctga cgcgttcggg atttaaaaat 2779801 ctttcaaaca gaaggtgatg cttaatcggg tcaacatctg tgatatacag cacatatgcc 2779861 acaagagaac ccgccgcaga accccttccc ggtcctgtaa caatcccttt ttcatgggcg 2779921 tgcttcataa aatcccacac gatcagaaag taatcgctga acttcatccg cttgatgaca 2779981 tcaagctcat attgaagacg gcgaaggtat cgttcatcag gcttgccgaa acggctgcgg 2780041 agtccctcca tacagatatc cgttaaataa tcatcagcgg acgttccgtc tggggtcgga 2780101 aaagacggta gacgggtctg cccgagactg acgtcaaccc ggcattgttc cgcgatctct 2780161 acagaagctt gcagtgcctc gggatgctct cgataaatgt tttgcatttc ttcgagtggt 2780221 ttcaaatcga gatcaggcaa atcttcagcg ggtgcatccg tcagtttttc ccccgcttta 2780281 atcgctttca aacaacggta ggcagcctta tcttccttcc ttatgtaatg cacatcgcct 2780341 gtggccgtaa cagggatacc cgtttcttct gacagcttta gaatctgctc agacaagact 2780401 tgattccctt taaaaggctg ataggagaaa taaaaagctc cctttccgaa tatagactga 2780461 aattccagcg aggcttgagc agcctgttcg aacagccctc cttcaagaag cgtttcaata 2780521 tatccttttt cgccgggcgt tattgcgata atcccttctc gataactgtg aagccatttc 2780581 ggcttcagtc cgccttttga tttagattgc agaacgctgc tgattttcag caggttttga 2780641 tagcctgtat tcgattttgc cagcaggacg agcgggtatg cttcaagctc gctgtcatct 2780701 gtaaaaacag aagccgtcaa accgattatt gggttgatcc ctctcgcctt gcaagcttta 2780761 taaaattgaa tagctccgta catgacatga tcatctgtca gcgccaaaga cgcatatccg 2780821 agcctgtcag cttcactgac gagttcttcc acagccgcgg cgctgtttag caggctatac 2780881 ccgctatgca cttgcaggtg aacaaaagac atgctatcac ctctttctca ttacgatcca 2780941 tttcttcctt cattataagg ccggtttcca aaagaaacaa atgttctttt ttgactcatc 2781001 atcatacttg tcctgaaagc tcaatatgat ataaaaggtg aggtgataaa gatggatcag 2781061 gaagcaggat ttatggtgaa ttttatcaat agctacttca ttgcgttagg ggtgctgatc 2781121 gggggcgcac tcatcggagg gctcggagca tacttggcag gcgaaccccc gcttacagcc 2781181 attacaaagc ttgccaaccg gttaaaaata tgggcgcttg tcgcagctat cggaggcacc 2781241 tttgatgcgg tatacagctt tgaacgcggc atactcgaag gcaatacgag agatatcttt 2781301 aaacagcttc ttttaattat ttcggccatg gggggcgcgc aaagcggctg gcttattata 2781361 tcatggctga cccaggagca tctttcttca tgagggtccc ccagcattac aaaaaaccgg 2781421 gatggcagcg ttttttcgcg ggaatgatgt gcggagccgt aatcagctgg ttctttttcc 2781481 tgtttactta cggaacattc caagaggagc aggtcagcct catcgaaaag caaaaagagc 2781541 atgtaaaaga cttgaacaat caaatttcga tctatcagga agacctccat aaactgaatg 2781601 aagataataa aagaaaactg ctgattcaaa gcgtcagcgt caaattgctg aatggggata 2781661 aatataaaat atcacagccg gataaaacga aattcgagga gcatgtaaag gatgatattt 2781721 cagaggtgat tacaaaagac atagagagcg tctatcaaac aaaggatctc ttgaagcgga 2781781 caattgaaaa taaagtctat atgatcaatg aaaaaaaata cgaggcaacc gtcagagaat 2781841 tgattattta tacgaggctg acagtggaac ttgaaatttc tttcgccaca taattatgga 2781901 ttttttttaa attctccaaa cttctgtcgc tttttcccat tcttttttat aaactatatg 2781961 tgaggcttaa tggcgaaagg aaggaggaag ggaaatggag gtttacagtg accgtcagtt 2782021 agcaaaagat caagcagccc gtctcagaca aggtttttct gcatatgccg aaacaaactc 2782081 actcgcttcc ctcatcaaaa aagaacttca atcacacaat ctccaagtct acgaggacct 2782141 tactgatttc ggctgctggt tcatccccgt cacagatgaa cactaagaga gagggtctcc 2782201 cctctactcg tgttctttac ataatgtttc cagatcagct aaaatacgat cagcttcatc 2782261 ccagctgtaa atagaggcgc ctgaagctaa cggatgccct ccgccgttat atttccgggc 2782321 aagtccgtta atgacaggcc ccttcgaacg gaatctgact ctgatttgat cgtcttcttc 2782381 tacgaaaaac acccaggcgc gaatacctga gatattgcca agcgtcccga caagctgcga 2782441 cgcttcagaa gccgttgtgc cgaatttttc aagcgtatcc tttttgatga aaacagaagc 2782501 cgccccgttt tcggacaaag acacattttg aaagataaag ccgttaagct tcaccacatt 2782561 cagttttgtt tcatacaatt gattaaataa ctctgaggaa gagaatggat actgaatgag 2782621 ctcgcctgca tattttagtg ttttttccgt ggtattcgga aataaaaagc gtccggtatc 2782681 tccaacaatg ccggcgtaga tcagctctgc cgctttcgta ttcagcttcc agccgtgctc 2782741 ttttccttct aaatacagct cgtaaatcat ttcacttact gagctggcgc ttgtatcgac 2782801 ccagagaagg tcaccgtatg gatcttcgtt cggatggtgg tcgattttca ttagtttggc 2782861 gcctgaagga taacgctgat cgtcgattct ttcctgattt gccgtatcgc agacaatgac 2782921 aagtgcgcct tcatatgttt cattgtccac ctcatcaagg gaatataaga aagagaggga 2782981 cggttcaggc gtgccgaccg caaaaatatt tttttcagga tatgtttcac gcaggatttc 2783041 cgtaagccca cactgtgatc cgtaggcatc cggatcagga cgcacatgtc tatgtaagat 2783101 aatcgtgtca tataatgata tggttctgat caattctgtt ttcatttgat actcctttat 2783161 tgtttttatt cattaaatca cattctctgc cgacggaaaa gaaaaataac gtcaaaacca 2783221 agcccgtttt tgtataaaat ggggttgtaa acttttacga tggaggattt catttatgct 2783281 ggttcttgtt tttttgattg ggctttcagc ctgcttttat gtgtactata aagtaaaagg 2783341 cgtacgggca aagccatctt tggcaaaaga aatatgttca gcaaaatcaa gcatggcctt 2783401 agggtcacta gtcctgttct acgggcttaa ccaaatgata ttattccatt cagtattaac 2783461 gttagtaatc ggcggtatct ttatcgtcat aggagcagga agcgcttggg caggttataa 2783521 agccttcagg cattacaatc cccttcacgc caaagaagct gaaagagatc acgcgtaagg 2783581 ggcgcctgaa cgtcccttag cttctttcca tcagctgaac catcagcatc gctttagaca 2783641 cgatatgacc ttggctgtgc acttccactt ccattttccc aaactttctg ccggcctcca 2783701 agatgcgagg tttgacttcg atgactgatt ccatctgcac aggcttcaaa aagaagatgg 2783761 tgatgctctc tatgacgagt tcgccgcgtt ttttcgagcg caaaaatcgg tttgccgctt 2783821 gcgtcaaaat ggtcgtaaat acgccataag aaatggttcc aagctgattt gtcatttgcg 2783881 gcgtgacttc atactcgtaa accgtttgat cttctttatc atcaccctca tctttaaacc 2783941 cccttgaaac gatatcatca agcttctccc cgacctgcgg ctgcttttga atcatttgaa 2784001 gagctttcaa tacgtcttgg cggctgatca tgccgatgag tttttggtgg ccgtcagtga 2784061 cgggaagcac ttcgatccct tcccatacca tcatttgcgc agctgaagcg acagatgttt 2784121 tcccaataac cgtgacggga tttttggtca tgactttttc tatagatgca tttcggtcat 2784181 ggccagcaat atcttttgat gtcagaatgc catggatttt catttgatcg tcgacaaccg 2784241 ggaagcggcc gtgccccgtt tcaaaatttt tctcatacca tttttcaagt ttatccttag 2784301 gcgaaagata taccgtgcgg tcagcaggtg ttaggatgtc ctccaccaaa acaatttctt 2784361 ttttgatcag ctggtcatat attgcccggt taatcatcgc ggcaactgta aaggtgtcat 2784421 agctcgtgga taaaatcggc agttcaagct catctgccag ctgcacaatg ctgtcatccg 2784481 tgttaaagcc cccggtcacc aatacggccg cgcccgcttc aagcgcctgc ctgtgtgcat 2784541 tgattctgtt tccgacaatc aaaagattcc ccgctgcggt gtaacgcatc atcgcgtcaa 2784601 gctccatcgc gccgatgacg aatttattca atgtcttatg gagccctgcc ctgcctccga 2784661 gcacttgtcc gtctataaca tttacaacct ctgcataggt aagcttttca atgttctctt 2784721 ttttcttttg ttcaattctg attgtgccca cacgttcaat cgtgctgaca aaccctttat 2784781 tctctgcttc cttgatcgct ctgtacgcgg ttccttcgct tactttcatt tcctttgcaa 2784841 ttcttcggac agaaattttt tcaccgacag gcagtgaatc gatatacgtt aaaatttgtt 2784901 catgcttcgt tgccaagcct ttcacctcta aggacagtct tcttgttttt attataaggt 2784961 ttcaaaggat ttatacgcaa tgaggctgga aaataaaaaa gaagcccgac cggcttctta 2785021 cagcgttgat ttcgttccag tcaaacgcaa ggaccacgtg attcctttta catcgtaaag 2785081 cggaaaaacc tttatttttc ttttaaatgg acatcaaccg ctgtcttaac aatatttcga 2785141 ttccctattt tagataaaac aaataaaact gcggatagcc atatcgcccc tatggccgta 2785201 tagatcaatg gatgaacagc tgtgtttgcg atccattcat ttattaatgt tctggcattt 2785261 accagaataa taaatcctcc tacaagcaca cccatcaatt gcggatgaaa cttctgcacc 2785321 agccatgctg cgataggggc agcgataatt ccgccggcca ttagtgaaaa cacccataac 2785381 caattgacgt cctcccatcc taatgaaata agaaaaccgg cggttgcaga tacggcgatg 2785441 gcaaattcac ttgtgtctac agtcccgaca actttcctcg ggctcaagcc tttgcgggat 2785501 aataaaatcg gagtggtcac cggtccccag ccgcctccgc ctgtggcatc tgcaaaacca 2785561 gcgatcactc ccaatgggat ggattgtttt cggtttaacg gcacatgctt cttctcaaga 2785621 gccggcttat attgaaataa aaacctgatc aatacatatc cgcccagaag gagcaaaaac 2785681 aaagaaatat agggtttcgc cacatctcca ggtaattggc tgaggaatgc cgcgcctaaa 2785741 aaagcgccta tagagccggg aatgacaagc tgataaacgg tttgtttgtc aacattgcca 2785801 aatttaatat gcgacactcc cgatgcggca gtcgttacga cttccgctaa atggacagaa 2785861 gccgaagcca cagcaggtgt gatgccaaac gccaataaca aagaagttga ggtaacccca 2785921 taagccatac ctaacgaacc gtctattaac tgcgacaata aaccaataaa tgcaaaaacg 2785981 attaatttct tcatcagaac accccatcta tatcaatcag atatttttga ctcttcattc 2786041 gaatctaaca atctcttggc gctttcatat aaaaaataag aggctttgat aattgcagtt 2786101 tcatctattg taaatgcagg gtggtgccaa tcatgatcac cgtctgttcc aaaaaacgca 2786161 aaggatcccg gaatatgctc aagataataa gcaaaatctt cccccgcggt tgatggggcg 2786221 ggatcaatga cttgaagttt cgctttatgt gcagcgtctc gcaccagccc cgtaattgcc 2786281 tcatcattac aaagcggcgg cggtccggaa tgccacttca catttgcctt taacgagaaa 2786341 gcggcagaaa tctgctctgt gactgcaaaa aaacgctgtt tcacttgatt acgaacctct 2786401 gaatcaaatg tacgaacagt gccctcaatg accactgtat ccggaatgac attccaagtg 2786461 ctgccgccgt tgattttccc tacggttaaa atcgcgcttt gcagcgggtt tacatttctg 2786521 cttacaatcg tttgcagggc gacaataagc tgagaggcgc cgataattgg atcaaaacca 2786581 ttatgcggca atgctgcatg agcacctttc ccttctatct ctactttaaa tcggtcaaca 2786641 gcagccataa gcgggcctgt ttttaaccct acagtcccaa ccgcgatatc cggtttattg 2786701 tgaaggccaa taaccgcatc aatgccatcc agttggccgt cctctatcac ttttgtagcg 2786761 cctgcacccg cttcctctgc tggctgaaat aataaacgaa tctttccttt cagactgtct 2786821 tgattttcct tcaataaaaa ggccgcacca agaagcgctg ccgtatgaaa atcatgaccg 2786881 cacgcatgca tgatcccttt atgtttagac gcataaggca atcctgtttt ttcttcaatt 2786941 ggcaaggcgt caatatcagc cctcaaagca atcgccggac cttctgactc ccctgctatg 2787001 tctgcgaaca cacccgtttt tagagcagta gggcgaatct gtatcccctt ttctttaagg 2787061 cattttttta taaaagcagt tgtttcaaat tcttcttttg acagttcagg atattggtgc 2787121 aggtgccggc gaatgccgat gagctgcttt tctagcgttg agagatttac gggattagac 2787181 tcctctttca acgtcaggat gtcatttcct gtagtctgat atggatagga gccttctata 2787241 tttctccaat aatccaaaga catatgttcc gctcctttcc ctatcccaat atattttctt 2787301 cagactcttc aacataagat gaaataaatc ggttcaattt atcagcaaga ccgcccgccc 2787361 caaatcttat atacttgctg gaaactttcg gattatcttc tttcaaaaag cttaaaaaag 2787421 ataaaatata aatgcgcctg taagctactt gtgtaattcc gtactcaaaa aaccagttat 2787481 caatgacatt gtatacgcct cggttgacgc catataggtt attacatttc ttgtaaaagc 2787541 agagatccgg aagatttaac tcctgatggg aaagaaggct ttcttttttg tttggtgcca 2787601 taatcccaat cagctcaaag cgttttgcaa cgcacgaaat atccttttta atttgctttg 2787661 ttaaagactc caaagaatca aaccttcttt cttctctaat tttaaagaga atgctgcatt 2787721 cgattttttc tccataaatg tctctatgaa agtcaaacaa aaaaatctcc aatgtctttt 2787781 caaggttaga gcccaccgtc ggtttcacac cgatattcat aacccctaaa tgaaattgat 2787841 gattgactgt cgccagaacc ccataaactc cattacgcag cccatgtatt tttgcatcta 2787901 catttgccgt ggggaatcca agctttctgc ctaattgttt tcctttcaca accgtaccgg 2787961 caatgatcgt caaaaaagtc agcctcctct ctcagcttcc gcattcgatc agacgaaacc 2788021 taatgatgtg atgaatgtaa aacggattga tgctgcggaa tgccaagacc gagattttcc 2788081 cgcaatgtcc cgccgcgata atcttgacga taaagccctc tttcttgaag aatcggaatc 2788141 accttttcta caaaagcatc aagtgttccc ggtatatccg acccaacgat aaacccatcc 2788201 gccgcctcag cgttgaacca agtttcaatt aaggatgcga cacgctctgg tgttccgatg 2788261 aatagagtcc gtggaaaagc catttcctgt gctacctccc gcaatgtcag atttctggct 2788321 tttgcttctc tcttaatccg gtctgttgtg ctttgaaacg cattctttcc cacatcgcca 2788381 atatcgggaa atggctcatc caacgggtaa acactcagat cataatcatc aaaaaaacgg 2788441 gccaaataag taacagcatt ttcaatcggt atcaattctg caaattcacg atacttcttt 2788501 tccgcctctt cttccgtatc tgccacaatc gggctgatcc ctggaaaaat ccgcacactt 2788561 gaaggatcac gcccttcatc agcagctcgg cttttcacat ccgcataaaa cgcttttgtc 2788621 tcttctaatg aattggaatg ggtaaaaatc gcatccgcat ttttagcagc aaactgccgg 2788681 cctgtttctg atgaacccgc ttgaaacact acaggctctc cctgcttaga gcgcccgata 2788741 ttcaagggcc cctctacttg aaaatacttt cctttatgat tcaggcgatg aagcttcgcc 2788801 tgatcgaaaa actgccctgt tttcttattg tgtataaatg cgtcatgctc ccaggaattc 2788861 cacagcccgc gcacaacatc caaatgctct tgtgcgatct cgtaacgttc agtgtgttct 2788921 ggcaaattag acttactatg gttgcgcgcc gctccttcct gcggcgaagt aaccagattc 2788981 cagccggccc tgcccccgct gatatggtcc agcgacatca attgtctgga gatagtgaat 2789041 ggctcagtaa aagatgtaga gaacgtccct actaaaccaa tatttttggt aaccgatgcc 2789101 agcgcagata aaatggtgat cggttcaaaa cggtttaaaa aatgaggaat cgatttttca 2789161 gaaataaata agccgtctgc aatgaaaata aaactaaaca aacctttttc agctgtttgc 2789221 gcctttttca tgtaaaattc aatattcgtg ctggccgagg gatcaacatc gggatgacgc 2789281 cagccgtcag ttgttccccc gacaccgtga atcatggctc caaactgaat aaaatctgca 2789341 cgtgtcatct ttttgcctcc tttatctgtg catgattagc aagtgcaaga tcaaggtgtt 2789401 caatgccgat ttcagttatc ccttgatact gattgccgcg cccgatttcg accacaggca 2789461 catggcgcac cccatatttc acctgtaaaa tatcccgaag cttttctttc tctgaaacat 2789521 cgatattttg gaacgggaac cctttttcat tcaaataatt cttgacttcc tcacaatacg 2789581 aacagccttt tttactccaa accacaatgt tcacaacatc actcattctt ctgtccctcc 2789641 ttaacgtttt gcagctaaaa ctgcatcgct cagcagctga taagacagct gtttttctac 2789701 agcatttttg atcggtgtaa aaataacaaa atcattgatt ttgtatgtgc ctgataaacg 2789761 tgttaattct tctgccactt cttcctttgt tccggcaata atcccggttt tttgcacgat 2789821 gatgtcatag ggctctgtga cgttttccag ataggcctca gcctgttcgc gggaaccgac 2789881 gttgacctta cgcccgtctt tcaaaaccac ttttatcgat tcacgcgaca caatatgttt 2789941 ttccgcttct tcttttgtat gtgccgcaaa aacagcgggg gcaagatgaa attcagcctc 2790001 agatcctggc gggagatgcg cgtcaaatgc tcggcgggct tccttcagca cttcctcttc 2790061 accgttaata aagtaagcaa agacaaaaga gattcccagt tttgcagcag aaatggcact 2790121 ctctgtgctt cctcccaata gaaaaatacc cggcttccga tcaacctgcg gcctaggacg 2790181 caatgcggca tagcggtggg tatcaggaaa atcatcccga acgaaatgag taagctcctc 2790241 cagtttttca tcaaactgac gcaccggttt tttatattcg gcctgcagcg cgtctgtgga 2790301 cagctgaaac ccgccgggcg ctttgcccac tccaagatct atacggccgg gagctaacgc 2790361 tgatagaaga tggaattgct ccgctacttt ataagagctg taatgctgca gcatcactcc 2790421 gcctgatgct aaacgaattt ttcttgtgct tgcagcaaga tagcctaaaa gaacctcggg 2790481 tgcagaccct gcaatctcat cattgttgtg atgttcggcc acccaaaatc ggtgatatcc 2790541 acattcttca gccatttgtg ccaatttcac tgtatgctgt aatgtatcag ctgctgtctc 2790601 cccttcacca atcaagcttt ggtctaaaat acttaagcgg atcatatcac cggctccttt 2790661 atgtgttctt ttggttcaaa taaatattcc ggcgaaacac ggcggagaaa ctgcctcgtt 2790721 ctgtcttttt tggtatggcg gaagacttcc tccggggttc cttgttcaac aatgactcct 2790781 tcatccataa aaacaacttg atcagagacc cttcttgcaa actccatttc atgtgtaaca 2790841 acaatcatgg tggctccggt tttcacgatt tccagcatta cctcaagcac ttcaccgacc 2790901 agctccgggt caagcgctgc cgtcggctca tcgaacagca gcacatcagg atgaatggca 2790961 agcgcccttg ctatccctac cctctgcttt tgtcctcccg ataactgact cggataagcg 2791021 ttcaatttat cttgaagccc gacctttctc agttcatttt ccgctacggc atacgcgtct 2791081 tgttttctca ttttccgggc aatcgtcaag ccctccatga cattttcaat caccgttttg 2791141 tgagcaaaca ggtggtattg ctgaaatacc attgccgtct gttttctgag ccagtgaacc 2791201 tcttttttgg acggaaagcg gcaattaatc actttgtcat gtatagaaat gatcccttcg 2791261 tctggacgtt ctaataaatt caggcaccgt aaaaaggtgg ttttccctga tccgctcggc 2791321 ccgataatcg tcacaacttc tcccttgcgt accgtgagat ttatcccttt taatacatgg 2791381 tggatgccaa actgtttatg gatattttta atctcaatca taaagtgcct ccttgaaatc 2791441 tggctgcctt tctctctaat actccatttg cggattctag gattagagtc agcacccaat 2791501 agataatcgc tgctccgata aacgcttcta aaaatgcata attatcagaa gcaacgatag 2791561 tcgccgtccc tgtaatctct gggacagcca ctatagccgc gatagaggtg gtatgcaaaa 2791621 agccgatacc caaatttgtg aagtttggga tggaaacctt cagcgcctgc ggcaatatta 2791681 cacgccgaaa ggtttggctg tatgtcaagc cgattgaata agccgcttcg acctgtccgg 2791741 tatccatcgc cagaatgccc gaccggatga tttctgtgag ataagctccg gcagttaaag 2791801 acaaggccat gatgacaaac atggagaccg gtatctcatt agcggaccag ccgagatgaa 2791861 aaaaactgct gacttgatct gcaacaggcg gtatccctaa ataaatcaac ataatgtgaa 2791921 gaattgcagg tgtacttcga aagaaagaca cataaaacct tgagcaagcc accaagccct 2791981 taattctaaa aattctaaca attatatttc caagagccac gagaaatcca aacacaatcg 2792041 gcaaaacagc catcatcaat gtcagaggaa tggtctttac catttctttc atggcggaaa 2792101 cgataaatgg aaagtcaaat tgcaatcttc tcccccctca tccgaagaaa tatatcaatg 2792161 tatgttcatg tcaaaaacag taacaatcct tgtttgattc ttcttgattc gtttttctgc 2792221 cactcgaaag aaccattcga ataaaaccgc tacagcataa taaacaatcg atagcgcaat 2792281 gtaaacttca agagaatggt tgcttgaggt aatcagtgtt tggccccttc cggacatatc 2792341 cataacacct attgaaaagg ctagagacgt atcttttaaa gaactgatca ccatgtttcc 2792401 catattcgga aacgcctgga caagtgcctg gggcagaacg attcgcctga aggcctgact 2792461 accgcttaag ccaatactgt acgccgcttc cgtttggcct ttatctacac tgcccacccc 2792521 cgctcgaatg atttctgcgg ctgccgctgc attgcttaac gcgtaggttg cgacagcagc 2792581 ataaaacggg tccatttttg atgtatcaat cccgataagc cccgtaagcg ccgggatccc 2792641 gtaaaacacg atgaaaagct gcaccatgat aggcgttccc ctgaaaaacg agatatacac 2792701 ttttgccaat tgatttacaa ttggaatatt atagatgcgg ggcagtgcca gaaagagtcc 2792761 taatacaaaa ccgaaaagca aggacagtgt taaaatgtat aatgtaaccg gtaaataagc 2792821 ggttaacgtc ggcacaaaat ctccaatcat gttcatatca aacgcttttt ccatcactgc 2792881 tccctctctt tttacctaat actgctcttt ggaatagtcg tcaccaagcc atttcaaact 2792941 gagccttttc aacgttccgt catcaatgat ttcctgtaag gctttatcaa tatcgtcact 2793001 taacgtttgt tcatttttgt taaacataaa atacactttg gcatttgaaa gcacattacc 2793061 gacggttttt tctttaatag tgctcgtctt gttttgaaag tctactgcaa aaggcgttga 2793121 gatcgttgcg tccgcacgcc ccgatttcag ctgattcgca gtctcatttg cgccttggcc 2793181 ctcataggca atctcaaacg gccgtccatt atcctcattc cattttttca gtacaagcgc 2793241 tccgttggag gttgcactcg taatcacccg ttttcctttt aagtcttcaa ttccacggat 2793301 cgtatcgtta ttttgaagca cagtaatttt taaaggaaaa tggttgtaag caaccttgtt 2793361 aaacagaaat tttttctcac gctctttgct tttctccatt tgatgtgcca cgatatcgac 2793421 tttatgctgt ccgaggctga caagcaggtt ggaaaattcc atcgttttaa atgtgaattt 2793481 ataatgtggc aggcgcttat caagctcttt gatcagttcg acatcataac cggttaaatc 2793541 gcctttttca tcgataaagc aaatattcgg aaattgggtt ccagttccga ccgtgatcgt 2793601 ctgtaccttc ttttgcccgg ctcccgtcgt ttgactgcct gcaccgcaag ctgacagaac 2793661 tgttataagc gaaaataata ttgccatgaa tgctgttttc gttttcatct catcgcccca 2793721 tttatttttc aaaacttgat tttgaataat ctgccccgag ccattttcgg cttagttttt 2793781 ttagcgttcc gtttttctcc agctttttaa tcgcttgatc cgtgtcatcc gccaaggttt 2793841 ggctgccttt attaaacata aagtacacct cggtatctaa taacacgtca ccgactgtct 2793901 tttggcggaa ggcgtgcgtt ttattctgaa aatcgacggc aaacggtgta gctatcgttg 2793961 catctgcgcg cccggtttca atttgattgg cggtatcatt gcttccctgt cccgcatatt 2794021 tcaaatgaat tgggctgccg tgcgttttgt tgtactttgt aatataatct gccgcatttg 2794081 acgtggcgcc aactatgact gtttttccgt gtaagtcttt taatgtatga atcttgtgat 2794141 tatcctcttt caccgtgatg tacatcggcg agtagttata tgggacttta tgatacaaaa 2794201 aacgcttttc tcgttcttta tttttggcca tattgtgcgc aatcacatca atttttttat 2794261 ttccgagact cgtcagcaaa tttgagaaat ccatcgtttt aaattcaaat gtatattgag 2794321 gcaactcctt atcgatggct ttcatcactt caatgtcata cccggtcaat tcaccttttt 2794381 catttaaaaa cgcaatattc ggaaaatctg ttccagtgcc gactatgacc gtttgagcct 2794441 gacgatctgt tttgttattt gtttgcgaac atcccccgcc aagtaatgca aacactgaca 2794501 gcagcaaaac caatccttta cgcttattca taggctgcct cacatcatgc ccagctgggc 2794561 gcacctaaaa gcgttgggtt aaatcgttcc ggaatcagaa ccttgtgcat catcacacct 2794621 atgtccccgt ctttttcctg ctcaaaatac acttcatacc ctctccttct gtacatgtca 2794681 gcaagccaag gatgcttgcg cgccgatgtg ccgagtgtca gcgcaggagc cttcagcata 2794741 tctcgaagca ctttttcttc aacatacgta agcagcttac ttccggcgcc ttgcccttta 2794801 tattccggca gtgtcgcaaa ccaccacaca aatggatatt ttgaaggagg cgtctcactc 2794861 tcccacggga acctgattgt aatcgttgaa atcagcttcc catcccgctc cagcacaatc 2794921 gctgaatgat gttcaatatt ttctgatacc atttggatat cagctctcgt ggatggccaa 2794981 tcaatatcca gctgccgaat gggctgaaat gcgctgttaa ccagtttcaa cagctccgat 2795041 gcatcttcaa cagttgccag tcgaaaaata tcatcactca tttttgtcac tcctcttcac 2795101 aaaatatata attcctattt gtttactaag cttttattgt ttatactata aagcatactc 2795161 tgatctttga ctaatcaaaa aaagtaaacc ttcacttcag taattttaat gatgaaaaac 2795221 aggagggagc acattggagt tacgctcaat caaaacgttt catacgattg taaaatttgg 2795281 aagcttctat aaagctgcag aaatactcaa ctactcgcag ccgacgatat cgatgcgtat 2795341 gaagcaattg gagcaggatt taggcgtact gctgtttgaa agaggaaaaa gcctgcagtt 2795401 gacaaaagca gggaagcttt tttatgaacg aacaggagat cttttgatgc aatacgaggc 2795461 gcttaaacac aacctctccg acttaaagga agaagaggca ggcattatca acataggggt 2795521 ttcagagcca accgccagtc tgatattccc cgagatttta aaggatttct taatggatta 2795581 cccaaagata acggttaata tcaaggttga tgacgccaat acctgcagtc aaaagctctt 2795641 agacgggacg attgattttg cagtctgcgg cgagccggag ctgattcttg aaaattacta 2795701 ccatccattt ttttatgaca cattaaatgt gattgtatct gatcaacatc cgctcgctga 2795761 gaagaaggct gtccatttgt ctgatttagc agaagagcgc ttcatattta cgcccgccaa 2795821 ttgccccatt cgcttacaaa ttgaacagca tttacataga gaactcggga atcgctacaa 2795881 aaaaatggag ctcacaagca gcatgtcaca tgaatattac gtacgtgaaa acatcggaat 2795941 ttcaatcttt accagcaccg cacattctaa accgttcaac ggcactaaag tcattccaat 2796001 tctgaacctg gatatcaccc cgcccatagg gctgttgaca aatcaaaaag aagttcattt 2796061 tgaccgcgcc acgaaggact tgatcgcccg gataaccaaa cgttttcagc agcgcagcaa 2796121 agaattggaa ggaacctctg ataagaccat tacaggataa ctgaaaaaat aaaaaccacc 2796181 tcctgattca tcaggagatg gtttcacggt ttaaagctcg atcgtctcac cgaccgacat 2796241 gactttgccg actccgcccg gcaggctgtc agcgaatgct tctgggtctt gttcgatgac 2796301 cgggaatgta ttgtaatgca ccggcacgac ctgttttgcg cgcagccatt cagcagcaag 2796361 cttggcgtct tcaggcccca ttgtaaagtt atcgccaatc ggaaggaaag caaggtcgat 2796421 atgattcaat tcgccaatga gtttcatatc agagaaaagt gccgtatcgc ccgcgtggaa 2796481 aatcgtttta tcttctacag tcagcaaaat accggcaggc atgcctgtgt aagtgatcgt 2796541 tttgttttct tcatctgtga tggctgatcc atgaaaggcc tgtgtgagct tcacttttcc 2796601 aaaatcgaac tggcgggagc cgccaatatg cattggatga acattcaagc ctttccagcc 2796661 taagtacaca gcgagctcgt tcggggctat aaccagcgcg ttattttgct tggcgatttg 2796721 ttcagtatca ccgacatggt cattgtggcc gtgcgttagt aagatgacat ccgcttttac 2796781 atcctccggc tttatatccg ttaatgaatt ccctgttaaa aacggatcaa aaataatatg 2796841 atggtccttc gtttccactg tgattacaga atgtccgtga tatgtcactt tcatttcttt 2796901 cacctcgtca catgattttg ttttttttat tttccctttt taaaaagctg aaaaacttat 2796961 gttgtttgat tcttgttaat gacattgagg cctccggtgg cttcaatgac agtccctgtc 2797021 acaaggtctg agttctcctc acacaagaaa gcgataatcc tggcaatatc ctcgcctgta 2797081 ccggatcttc ctatcggcgt tttttctttg ccgattcgca ttctggcttc ctctatcgat 2797141 gcttctttca tgtcgccgac aatgtctcct gggcaaacca tgttggcggt tatgccgaat 2797201 tcggcttctt caatggcaat tgtcttcgtc aaagaagcca agcccacttt cgcagcgcca 2797261 aatgccgatc ggtgaagcca gccgggcgcg tgagccgcac cttggaatcc gtacgtaata 2797321 atgcgtccaa attgctgttt tctcataata ggaataaccg ctttgaataa atgaaagacg 2797381 gcgcttaaat ttccttccag catgccatac cattcatcat cagtataatc ggctaacttt 2797441 ttacgttcaa atatgtatgg tccagcgttg ttaatcaaaa agtcgatcct tccgaagcgg 2797501 tttaaggcag cctctgcaat acgcagcaga tcttcttttt tggtgacatc accttttaca 2797561 aattgcagcc ggtcaagaca atcgggacag gcttccttca ggcggctgac tgcctcctca 2797621 tcctgtctgt aattgactgt tactgaatac ccctttgcaa gcaacgtttc agtcactttg 2797681 cggcctaaac ccttcgaacc ggcagtaatt aaagcatgtc gcacatgaat acctcccaaa 2797741 gcaacgtcgc cgctttcaat aaagtgtttc ttcttctact ttactataaa aggcttgcaa 2797801 tatcactttt tacactttgg catacaaaaa aagctgcctg tacagacagc ttattctgca 2797861 ggagatgaag actcctgatc aggcatatcg acataaccgc tttgatatgc ttctgaaatg 2797921 agccttgttg tctcctggct ttcttgttca tcataaatat agcgttccgg ttcttttttc 2797981 atcattctgc ctcccatcat tatagaggta ggttggctat aatgacggga ttttatgaag 2798041 gaaattttaa caaactcctg ctgccacgca agctttcgct ttttcaagcg cctgttccac 2798101 ctgtttgaat ccggtgcccc cggcgctcat tcttttttca actgcgtagt aagggtctaa 2798161 cacagtgtaa atatcttctt caaatagtgt gctcgcctgc tgaaactcgc caaacggcat 2798221 atcgcttaaa tagatccctc tttcgatgca tgtgtacaca agtttcccga ccacttcatg 2798281 cgcttctctg aacggcattc cttttttagc taaataatcg gccagttccg tcgcgtttga 2798341 aaagtcttgt tttgttgctt gcttcatgac gtctttgttt acagtcattg tttggatcat 2798401 gcctgtgaag atttgcaggc tgccctccac cgttttcacc gtgtcaaaca tgccctcttt 2798461 gtcttcctgc agatctttgt tgtaagcgag cggaagtcct ttcatgatcg taaacagccc 2798521 catcatatcg ccgtatacgc gtcctgtttt gccgcggatc agctccgcca tatcagggtt 2798581 tttcttttgc ggcatcatgc tgcttcctgt tgcgtacgta tcgtcaagct cgatgaattt 2798641 aaactcctgc gagcaccata aaatgatttc ttcagagaaa cgggataggt gcatcatcag 2798701 catactgctg ttgcttaaaa actccaaaat gaagtctctg tcgctgacgc cgtccaagct 2798761 gttttcataa atggcatcaa agccgagcag ttccgctgaa taatcacggt caattgggaa 2798821 ggttgttccc gcgagcgccc cgcagccgag cggagatttg ttaatccgct tcattgaatc 2798881 ctgaaaacgc tccttgtcgc gctcaagcat ccagaaatac gcaagcagat ggtgagcgaa 2798941 tgaaatcggc tgggcgcgct gcaaatgtgt gtagcccggc agaatcgttt caacgttcgc 2799001 ttccgccttt tcaatcagcg cactttggaa tgcctcaatc agctcgatga tgtggccgac 2799061 atgattcttc aagtataaat gcatgtcagt cgccacctgg tcattccggc ttctgccggt 2799121 atgcagcttg ccgccaagag gaccgatttc gtcaatgagc attttctcaa tgttcaaatg 2799181 aatatcctca taatcgactg agaattccaa tgctccctcc tctgcttttt gcaaaagggt 2799241 attcaggccc tctcggattt tcaactcttc ttctgctgtc agaataccgc attttttcag 2799301 catggcagca tgtgcgagag accctgtaat gtcttcagca actaaatttt ggtcaaatga 2799361 tatggacgcg ccgaactcgt cgacccattt ttccggtgtt ttttgaaatc ggcctcccca 2799421 aagcttcttc atgctttaat ctgctccttc tttttcacga tgctgttcac ttttgtcgga 2799481 agtccccaaa gctcgataaa tccgattgct gcatggtgat caaatgcatc gtcttttgta 2799541 tatgttgcaa gtttttcatc atatagagag tattccgatt tacgtccttc tacaattgca 2799601 tggcctttaa acagcttcac gcggacaatg cctgtgacat gcttttgcgt ttcttttaag 2799661 aaagcgtgca gcgcgtcttt taacggtgag aaccataagc cgttgtaaat gatttctgac 2799721 attttttgct cgatgatcgg tttaaagtgg gctacctctt tcaccagtgt caaatcttct 2799781 aattctttat gcgctttgat cagtgtcatc gcaccagggc attcgtatac ttcccgggat 2799841 ttaatgccga cgaggcggtt ttccacgtgg tcgatacgtc cgacaccgtg cgcgcccgcc 2799901 atttcattca gcttcaagat cagctcagaa agcgagtagg aaacaccgtc aatggagaca 2799961 ggcacgccct gttcaaatgc aatttcaatc acttccggcg tgtccggcgt tttttccagc 2800021 ggagctgtta aatcgtatgc accttctggc ggcgccgccc atggatcttc taaaatgccg 2800081 cactcattgg cgcgtcccca gaggttttgg tcgatagaat acgggctgtc aagattgatc 2800141 ggaatcggaa tgccgcggct agccgcatat tcaatttctt cttcacgtga ccactgccat 2800201 tcgcgaaccg gcgcgatgac ttctaggtca gggtttaatg atttaatgga gacttcgaaa 2800261 cgaacctggt catttccttt ccctgtgcat ccgtgggcaa tcgcctgtgc atcttctttt 2800321 tccgcaattt caaccagttt tttcgcgatc agcggtcgag ataatgccga aacaagcggg 2800381 tattttcctt catacattgt gtgggcctgc aaagagataa gcgcgtaatc ctgtgcaaat 2800441 tcttcttttg catcgatcac gtaggagttt gtcgcgccga cttcaagcgc tttctgctga 2800501 acaaatgcca aatctttgcc ctcaccgaca tccaggcagc aggcgattac attatatcct 2800561 tgctcctgaa gccattttat tgcgacggaa gtatcaagac ctcctgagta tgctaatacg 2800621 acttttttct gttctgacat gataaaaatc ccctctcaac cgtgtttcta ttttgtataa 2800681 aaataaatta tatttaataa aaatacattt tgtatgtata cactttaaca agtacgtttc 2800741 gttttttcaa gccttttata aaaaaaactt cacctaaatt tcaggtgaag tttcatagta 2800801 tttattcatt tacttgtctt ttctgatttc tctgaccaca tgcgcaagtt cgggaataat 2800861 cagcttattc attgccagct ttactgcgcc gcttgagcct ggcgttgaga aaacagcggt 2800921 atgctgaatg acgccggcag ttgctctcga catgattgcg gcagagccga tatcctctgt 2800981 ataactcagc atcctgaata tttctccaaa gccgggcagt tctttcgaaa acagcggcgt 2801041 tatggcttca attgtgacat cccgatctgc tatgcctgtc cctccgttta agagtaccgc 2801101 gtctgtctgt tcatccatgc agcccgcaag cactgaccgt tgcaaagcat ccttttcgtc 2801161 ttttacaatt tcatatgcgg caatatgatg accggcttct tctaaaaatg agatcatcag 2801221 cttgccgctt ttatcggttt catctgtcct cgtgtcactg acagtaatca ctttgcaccg 2801281 aacgatatcg ggagcttctt gtttatgctc ttgaacgctc attggcccac ctcttttatg 2801341 ttttctgtct gtcactatca tgcatcaaca aaaaagcaca ttcaagagaa tgtgctttca 2801401 tgcgatttat tttgctaaac gaacaacgtc gcgcgcaatc atgacttctt catcagtcgg 2801461 gatgatcatg acttttactg gagaatgcgg atagctgatg aaagcttcct cgccgcgcac 2801521 gttattaagc gcagggtccc agtatacgcc catgaattct aaaccgcgaa gaacgcgttc 2801581 tctgacttcc acactgtttt caccgatacc ggcagtaaag atgatcgcat ctacaccgct 2801641 cattcttgca gcgtaagaac cgatgtattt gtggattctg cttgcgaata cttcaagagc 2801701 cgtttccgcg cgctcatttc cttctttcgt agcttcaacg atgtcacgaa gatcgcttga 2801761 gaaaccggaa atgccgagca gtccgctttt tttgtttaat gtattcagta cttcgtcagc 2801821 cgtttggcct gttttctcca tgatgtatgg gatcagggca gggtcgatgt ttccagagcg 2801881 tgtgcccatt gctacaccgg caagcggcgt aaagcccatg gatgtgtcaa tagattttcc 2801941 gccttcaaca gcggcaatac ttgctccgtt tccaaggtgg caggaaatca ggcgcaagtc 2802001 ttttaacgga cggccgagaa gctctgccgc acgctcagtt acatatttat gtgaagtgcc 2802061 gtggaagccg tatttacgga tgccgaattt ttcatagtat tcatacggca agctgtaaag 2802121 gtaagactgc tcaggcattg tttggtggaa tgctgtatca aatacagcta ccgcaggaac 2802181 atttggaagc acttctttga acgctttaat tccaacgata tttgccggat tgtgaagcgg 2802241 tgccaattca gaaatatctt cgatttcctt aatggtttca tccgttaata aaacagaatc 2802301 gctgaatttt tctccgccgt gaacgacacg atggccaatt ccgtcaattt cattcaagtc 2802361 tttaataatg ccgaattccg ttaacttatt cagcagcatt ttaacagcta ccgcatgatc 2802421 tggaatatca gttacttctg tatttttttc gccgttcaca gaaattgtga atacgctgtc 2802481 ggcgataccg attcgttcaa ctaaaccctt cgttaaaacg gtttctgaag gcatttcgaa 2802541 aagctgaaat ttcaaagacg agcttcctgc gttaattgca ataattttgg acatgattga 2802601 cgctccttta tactctgtat caacaacttc gtttttcgta cttttttccc ggtgaatatc 2802661 aacatcttct ccgaaaaata tctgactttt ccatttaaac attgtcatgt cggcttttca 2802721 agtcaacttg cgtattgata acgcttacaa taagaagtcg ttattttcag acacattcac 2802781 tataggtttt gtattgatga acgcttacaa tttgcggttt ttccctctgt attttgtgtt 2802841 tcaaagctgg attcaattcg tcaagtccgg tcttcaaaag cataaataaa agcagcttag 2802901 gcatcgacct catacggctg tctaagctgc ttttaaaaca cttacttttc ttttttaaac 2802961 cattcatcaa attgagccat catatcaagc atcgcctttt gattggagaa agacggaaga 2803021 ttcgcaagca gaatttgccc cggcgctttc gtattctctc cttgtttctg aagcacaagg 2803081 atgcttttgg catgagcttc gtctttaaaa atagattttg gcagctgcaa cagtgcgttg 2803141 atatgaacct tatctttgaa aaactgtttc agcttgccgc tttgggagct ctcaaacaaa 2803201 tgattcggaa tcataaaaaa taagtagccg cccggtttgg tatgcttgac gctctgttca 2803261 ataaacagat gatgagcgaa ggaatggcct tcgtcagctt tgagctcaaa cgcttctgct 2803321 ccttcgtcat tcggataata gccgactggc agatcacaaa tgaccgtgtc aactggatcg 2803381 ataaacaacg gctcaaggct gtcctggtgg aaaagctcaa gctctttttt cagaaggttc 2803441 gcttgggcat aggcgatctt caagagcaca tcatcaattt caatgccaaa gctgtttgcc 2803501 gttttttcag acagctggtt cagcacggta aacagaaggt tcccagttcc cagggctgga 2803561 tcaagaatgg tcagttcctt tttgtccgcc ataaatttat tcaccaaata gctgatgaaa 2803621 agcccgatcg tatccggcgt catttgtctg tttggatgcg agatatcttt cattccttta 2803681 aggacggcaa gctgaaaagc cttgcgtacc cactcatgct catacgtgcc gaattccgct 2803741 ttttcaagca gagcctgaag ttgtttggtt ttctgatcag caggcagttt cagctgatcc 2803801 gttttttcaa gaaaatacat ttctcctgct tcggccagcg cctctatata tgaaatctgc 2803861 aattcattct ttatcataat cgcggcttcg tttaacagct catacaccgc acctacatgg 2803921 tctttttgca tattgtgttc ctccttgcca tgaaaaaagc tccggcggca gcctggagct 2803981 tttttccctg cttactttac taatgcctta gcagcctcaa ttggcttttc atagttcggg 2804041 tggtttgttg cttcgcttac atattcagcg taaacgactt ttccgttctc atcaaggaca 2804101 aatacggaac gcgcaagcag acgaagttct ttaatataca caccgaacgc ttcgccaaat 2804161 gacatatctc tgtggtcaga cagtgtttcc actttgtcaa ttccgttagc gccgcaccag 2804221 cgcgcttgcg cgaatggaag gtctgcactg attgtgtaga cgttgacatc tccaagcttt 2804281 gcagcttctt cgttaaaacg gcgtgtttgt gcatcacaaa cacctgtatc aattgaaggg 2804341 ataacagaaa taatcgttac ctttcctttc atgtcagcta acgatttttc ttcaaggctg 2804401 ttagtcagca ctgtgaaatc aggagcttga tctcctacct tcacttcttg tccgacaagt 2804461 gtaaccggac cgcctttgaa tgtaatttca gccattataa ttcctccctt ttgtatgtat 2804521 gtctctatca tagtaaagtt tcctgcaaac tgcaaagttt atgccaaaaa aaagttaact 2804581 gcggccagcg cagttaacct ttttttaata attcatattg ttcatttggt tttgattttg 2804641 gccttggctt tggtttttgt tatttttctt gaacatttgc tggatgcgct cgagtgtttg 2804701 aggggctgcg tctaaaattt tctctattaa atgggtattt tcatctaaat gaagcattct 2804761 gatgcctgtc gatccgacaa ttaaaaacgc gatcggcgta atggacacac cgcccccgct 2804821 tccgcctccg aaaggaagtt tctgttctct tgtctcatcg tcttccgatt tcttttcggc 2804881 cggctttccg ccaaactcgc ttccgcctgc ggcgaatccg aatccaactt tagaaacagt 2804941 taaaatcaca cttccatcag gcgtttccac tggatctccg atgatggtgt taacatcaat 2805001 catttccttc aagttttcca ttgcggtttt cattaaacct tggatgggat ggtctgccat 2805061 atacgcttcc tccttaaact gatgaatcat tctttgaagt cattctagcc gacggattct 2805121 tctttaatac ggatagctcc cgtccgtatt tgacgaattt gaaagctgca agcatagcat 2805181 gtccaaagcg aaaaaagaat atacactgaa aatgggtctt ggaaacaggg acttgaaacg 2805241 acgggatcac ctcatagaca ggtttattca caaagtccag gtggtcgtag agcattgctg 2805301 cgataccgcc cttcacgccc catacagcac cggttaacac acctgtcact gccgcgtcct 2805361 gaattccgat tactgtaacc cattctagtt ttgtgatatg taaatgcgcg agaaaagacg 2805421 cgctgatttt ccgcagtctg gtgacctgat gcaaaagcat ttcgatttta ttaatgcttt 2805481 gctgcacatc gttttgtgta atttttttct ttccgctgct ttttttcatt ttggattcag 2805541 ttttttgttt gatatccact gttccgtctt ctttgttcac cttaatcgcc gggattgttt 2805601 ttttgatcct tataaggcca aacagcgccg taatcttcaa ggtcaatttg tcattatcat 2805661 cggcatgaag atactccagc gcgacatgga ttttcattct gagaagcagt acgatcccta 2805721 tgagaataag aatggctgtc agtacataca ccatattctt cacttcctct aggagcatta 2805781 tcgccaattc ctaaaaaaat aaacccggac ggaagtccgg gttatcggtt atttgcggta 2805841 taatttttca tgcaccacgg tggtatccgc gatgtaatca tgaatccctt gttttgtagg 2805901 tgaaaaggca acaacgatat ataaaatcca aatcttatca atataccgtc caaccacttc 2805961 acgaaaaatc actgtactcc atgtcagctt gctatcttgc ttcacagaaa ccactttgag 2806021 gccgaacacc attttaccaa gcgtctgcct gaagtatttt gtcatgagtg cgaaataggc 2806081 aagatacaca ataagcgttg tcacactgta ggccgagaag gtaaacatgc cggatgtttt 2806141 cggcagatcc aatacggtaa agaggggaga aacgagcaaa tggtttaatc cccatatcac 2806201 gagccaatca agcaggaaag cccagaaacg aacccaaaag ccagcatagg catgtgtcag 2806261 cagctccgct tcttgcgggc ctttgatgtc attgcgctct aactcttcat atgtcgcgtc 2806321 cattattgtt ccctcctact tcgcatagag atacatcatt ctcggcgaac cggattgcga 2806381 tagaatttct ctcatattca aaaaatcaat ttcactttta aacattttgt tcgcgcccat 2806441 ggaaaacagt gagcctaatc cgaagctttc ctcataagaa atgacagagg cgtttttcaa 2806501 atccttgtga tcctttttca tggccgtaat ggtatcgtca taaaaaccaa gctcatcaac 2806561 gaggttcagt tttttcgcct gccgtccgtc atacacgcgg ccgtccgcaa ttttctttac 2806621 ctctgctttc ggcatgccgc gcccttttga aatgacatca acaaagcctt catacgaatt 2806681 atcaaccatc gattgcatga tgtttttttc ttctttcgtc atctcacggg aaggagacat 2806741 aatgtcctta tgggccccgc tcttaatcgt ttcaaaagaa atgccaagct tgtcggcaag 2806801 ctttgaataa ttgacgcttt ccataatgac gccgagtgac ccggtcaggg tttccggtgt 2806861 cgcaaaaatc ttatcagccg ctgttgagat gtaatagcct cctgatgctg ccatcgaacc 2806921 cattgacacg taaatcggtt ttttcgtttc tttcttgatt tcttccagtt tcttatgtat 2806981 ttcagcactt tcatacactc cgccacccgg agaattcacc ttcagaacga tacctttgac 2807041 cgtcttgtca tcttttgcgc gctcaaggtt ttttaagaac gttctgtggt tatatccgtc 2807101 tgcaccaagc agactgcttg agtccccatt atcctgaatg gtgccgctga cctctaatac 2807161 ggcaatttta cttgagggac tgccgttttc cagcgtcttc tcctgcgatt catccgtcag 2807221 tgatgtgaga tccgtttgag cgcctttgac gctttcaaag aaactcatag agatgctgac 2807281 gataatagac acgccgaaaa tccccagagc aatcactaat gcaatccatc tttttgcatt 2807341 cattttttct cctccttttt cctaaactct ctcattatac gattcaatat gaaaaatgtt 2807401 tcacttcatg agaaagctcc ggcttaacgg gctgccggca aacgtggtac acttatggcc 2807461 aaaggtattt tatcacaaat actggatggc agaaaaactt aaatatgaca gcaaagggga 2807521 aatgggatat gaccgatcaa cgccgtaatg tttatttttt tcacaaacag gatcaggaaa 2807581 cgaacgaaca agcccgctcg ttaacacaat tagcggaaga gcatggattt accgttgtga 2807641 accagcactc agacgccaat attatcgcta gcattggcgg ggacggcaca tttttgcagg 2807701 cagtcagaaa gacgaatttt cgtgacgact gcttgtacgt cggcattacc aaaaagggga 2807761 aagctcattt atattgcgac tttcatagtg atgagcgaga aaaaatggtc gatgcaatga 2807821 cgtttgaaca aattgaagtg agaaaatacc cgctgattga agtgacagtg gatcaagcca 2807881 gtccttttca ctgcttaaac gaggtatcca tccgctcaag catcatcaaa acctttgtga 2807941 tggacgtgct gattgacgat ctgcactttg aaacgtttag aggtgacgga atgattatct 2808001 caacgcctac agggagcacc gcctataaca agtctgttgc aggagctgtt gttgatccat 2808061 tgcttccatg catgcaggta tcagagcttg catcccttaa caataatacc taccggacac 2808121 tcggctcgcc atttgtcctc agctctgacc gaaagctgac ccttcgtgtg gtgcaggacg 2808181 gcaacgaaca cccaatcatc ggcttggaca atgaagcact cagcacgaga aatgtgaaaa 2808241 cgatcgaaat caaactgtct aataagaaaa tcaaaacagt caaactaaag gacaattcat 2808301 tttgggaaaa agtgaagcgt acttttttat agaaaataaa aggacaggct gctgcctgtc 2808361 cttttatgat ttctcatata caatctggcc gttaatcacg gtttttttaa tctctaaaag 2808421 atgaagctgt gcggggtcaa tggcaaacgg atcaccactg agaactgtaa aatccgcgtc 2808481 atagccttcc gcaatttttc cgcgtgactt ctctttataa atgataccgg cgctaccttc 2808541 tgtataaagc tttatcgctt catatacagg taaacattca ctttcattat agcttggccc 2808601 gttttgctca tgactgcttt tccggaggac cgcggactgg atccctagaa gcgggtcaac 2808661 aggctcaatc ggggcgtctg aaccgcccgc gcataaaatg cctttagata tgagggtttt 2808721 ccaggcaaat gcagtcttca tccggtcttt tccgagacgg tcaatgaccc acggaaagtc 2808781 gcttgcaacg aagtgcggct gaaggtcaag tgcgatcggc atgcgtgctg ctctctcgat 2808841 taattcgtta tcaagcactt gagcatgaat aagccgatca tgccggccgt ttttgggcgg 2808901 atgcttttct attgcgttca gcactttttc aaaagcaaga tcgccgattg catgaacagc 2808961 aacctccatc cctttttctc tcgctttgcg aatgagccgg ccaagggttt cgtcatcgtg 2809021 aacctgaaca ccatttgttg atggatcatc ctgatatggt tctttcaata aagccgttct 2809081 cccgccaagc gccccgtccg caaagatttt catagcaccg aactccacat acgggccgga 2809141 cagcttctcc agctgctccc atcgatcgac agcttcatga tgaacgagca aatggcagcg 2809201 aaacggatac tttccgccag cggcagcttt ctcataagct ttcatcggca ccgaaacatc 2809261 accataatag gacaagtctt ccgaatgacc gcccgtcagg ccttttgtcc agcaatcctt 2809321 tattgcagcc gttaatgcct catcaacata gtgctgggag actggcggga cagccttcag 2809381 aatcaaatcc tgcgccttat caaacaggag tccggtcggc tcgccatttg catcttttac 2809441 gatgactccg ccgtcaggat caggagtatt tcttgaaatt cccgctgctt gaagagccgc 2809501 agaattgaca gctattgcat gccggcatat acgcttgagc aagacgggcc tgtcaggaaa 2809561 caggcgatca agatcatgct tagtcaagta gtcaggtgtc tcaaactgat tttcattcca 2809621 gccttctcca atgagccaat cgtttttagg aagctgccgc tctctttcct tcgcagcctg 2809681 taaaattgaa tctttcgacg tcagtgcgga cagatcgagc tgaagctgtt tctcaccgtg 2809741 gccgatcaaa tgtagatggc tgtcaacaaa accggggaac atcactgctc cgttcaggct 2809801 gatttcttct gtttccggcg acccgtactt ttccttcaaa cgttcatagc tgccggtgcc 2809861 ttttataaca ccatcctcaa cataaactgc ctcagtccga tcgccttctt cgagcatcgt 2809921 ataaatgaaa ccgccgtgcc atatcgcctt cattcacgtt cactctcttt ctttacgcct 2809981 ttttattggc tttgagctgt tcttcacgtt ttcttaattc cactcgtctg atttttgcag 2810041 aagccgtttt cggcaggctt tccacaaatt caatttctct aggatatttg tatggagcgg 2810101 taatcgtctt cacatggttt tgcagcattt tgacaagctc atcactgcgt ttttcatgat 2810161 tttgcaggac aacatatgcc tttacgatgg agcctctgat ttcatcaggg cttgcgacaa 2810221 cagcacattc ttttacttct gggtgcttaa caagcgcgtc ttccacctcg aaaggcccga 2810281 tcgtatagcc ggagctgata ataatatcgt catttcggct ttcaaaccag aagtaacctt 2810341 cctcatcttt tcttgctctg tctcccgtta ggaaataatc gccgcgaatt tgtgttttca 2810401 ttctttccgg atctttaaaa tactctttaa agagcgcagg cgtactgagg tgaacagcga 2810461 tatcgccaac ctcaccaggt ttgcagattt caccgtcttc atttatgatc tccacctgat 2810521 ttcccggtgt cggttttccc atgcttcccg gtttaatagg cgtatctttc aaaacaccaa 2810581 ccaaaagcgt gctttctgtt tggccatatc cgtcccgtac cttaatgcca aagtgctttt 2810641 ggaaaacatc aatgacttca cggttgagcg gctcacctgc ggaaacagcg ctgtgcaggg 2810701 cagaaagatc aaagcgtttc aagccttcaa ccttcgccat taagcggtat tctgtcggag 2810761 tgcagcagaa aacattgatt ttgtagcgat ttaaaagctc tagatatttt tctgctttga 2810821 atctgccgtg gtacacaaaa ccggttgctc cgctgccaag caccgctaaa aacggactcc 2810881 atacccactt ttgccagcca ggggcagcag ttgcccagac gatatccttt tcagaaatgt 2810941 caagccaagc gccggcagaa gtttttaaat gagcaaatgc ccatccatgt gtatgtacaa 2811001 cacctttcgg ctgacctgtt gtcccggatg tataagataa gaaagccata tcatctcttg 2811061 ttgtgtcagc tgttttaaat tggcttccgt ccgcttcaat tgataagagg tttttccagc 2811121 cggcatcatt ttcaccaata gacagtgtaa tcagtttgtc agccgtactg acatcccgga 2811181 aagcgccaat aaattcggag tagacgatag cgccttttac ctctgcatgt tcaatccggt 2811241 attcaagatc tttcgcgcga agcatttcgg agcacggaat gacaaccatt cctgatttca 2811301 ggatagccaa ataaacagca taggcttcaa gcacccgcgg aaccattaca atcagcttgt 2811361 ctcccttttt aaatccaaga tcagctaagg ccgctccgat tttatttgtt tcttccatca 2811421 gcttttcata cgaccaagat tcttgcttgc ccgactcgtc ctcccaaaga agagcggttt 2811481 tttgtccagc agcactgaac ttttccattt cattcactaa attatattgc acaggggcaa 2811541 ttaaatcttc acgttttaac acgaacaact cctcactttc tccacccatt atacataaat 2811601 acaggctctt tccgtaagga tatgcctaaa agcaacctct gtaaacatag attttatagg 2811661 ccgctggtcc ttttttatat gtaaaaaatg aaaaagagtg gggatacccc cactcctaag 2811721 ccattatgtg aaattgtaaa ttagaattgt cctccgccca tgttttgttg agcaaaagat 2811781 acaagacgtt ttgtgatctc tcctccaaca gaaccgttag cgcgagaagt tgtgtctgct 2811841 ccaaggttta caccgaattc agaagcgatt tctaatttca tttggtcgat cgcttgagca 2811901 gctcctggta ctaaaaggtt gttgctgtta cctgagttat tgttagccat gtgtctcacc 2811961 tccttgtgag tatagaatgt gtcaaaacac atggcttcat tcagaaaaac tttggtaatt 2812021 gtatacagga gctgaaaatt gatttaaaag agttcagcga atttatcgtt agcttcttgt 2812081 tcgctataaa gggtcattgt ctcaatgtta tctaccgctt cttgaatata cggctcgaaa 2812141 tcaacaaagc tttcaaagtg ttcaattttc tcttttttag ggcgtgtttt cgggcttggc 2812201 ggtgtaaaga tcgtgcagca gtcttcaaac ggctgaatac ttgtctcata tgtgccaatt 2812261 tcccgtgatt tttcgatgat ttctgttttg tccatggcga ttagcggacg caaaatcggt 2812321 gttgacgtca ccgcattaat tgcatacatg ctttcaagcg tttggctcgc tacctgaccg 2812381 aggctttctc ccgtaataat ggcaagcccg tttctctttt ctctgattct gtcggctatc 2812441 tgaagcatga ggcggcgggt tgccgtcatt gtgtaatttt caggaatttg tttttggatg 2812501 agctcttgcg tttttgtaaa tggaacaata tgaagtgtca tgcttccccc aaaacgggac 2812561 agacatttcg ccagatccat taccttttgc tttgcgcgct cgcttgtgta tggcgggctg 2812621 aagaaatgaa cagcttctac cgacaatccc cgtttcatcg cataaaaacc ggccacaggg 2812681 ctgtcaaaac cgccagaaag catcagcatc gcttttcctg ctgaaccaac tggcagcccg 2812741 cctgcacctt tttcatcacg aattgtcaaa aatgttgctt cttccctgat ttcgattctg 2812801 agcgggatgt ctgggttgcg aacatcgacc gtcaatcctt ctgtatttcg caaaatatgg 2812861 ccgccgattt cagcgttcat ctggtttgta tctaattcaa attgcttata cgctctcttt 2812921 gtcgcgactt taaacgtatc acctggttta tactgatctt tgatagcctt tagtgcggtt 2812981 gccttaatat catcaaggcg gctgtcacac ttaattgcca ggctgaagct ttgaatccca 2813041 aacacttgct ttaaatgagg aaaaagagcc tcaggatcct ctccatttaa tgtaatcgtc 2813101 atacgatccc tgttggaaaa gtattttaaa ttcggatagt ctttcaaaac gagtctgatg 2813161 ttttgtttta agcgctcaat aaagcttttt ctgtttttgc ctttggtcga aatttcccca 2813221 aaacgaatta atatatgatc gtaattcatg ttctacctca tcatttccct taattttttg 2813281 atgccaggac gaagcgcgtt cataaacggt tctgccacat cgcttgtctg gctgtaattt 2813341 aaactgattc tgatgctgct tccggcaatc tgctctcctt tgcccatctc taagagaacc 2813401 ttgctgggct tatgttcttt tgccgagcaa gccgatgttg tggagacgaa tatatcctgt 2813461 tcctcaagca tgtgtaaaag cacttccgct ttaatccccg gtacagagaa attaataatg 2813521 tgcggcgcgc tattcatttg aggcgtgttg ataacgacgc cctcaatttc actcagccta 2813581 ttcataaaca attcctttac ggcagtcatc gtgtcaagcc gtgtgtcaaa atcagcagag 2813641 gccagattaa tggccttggc aagcgaaacc gcaccagcag tatgttctgt tccggcccgt 2813701 atgccttttt gctgagagcc tcccgttatg agcggaataa ggcgtgttcc ttcttttaca 2813761 ataagtgcgc ctgtcccctt taggccgtga aatttatgcc ccgaaattga acatagatca 2813821 atgccggcct tttcaattgc caagggcact ttatagatgc cctgcacata atcgacgtga 2813881 aacaaaatgt tcgaatgctc tttcagcact tctcctgccg cttcaatcgg ctgcacggaa 2813941 ccgacttcat tgttcacatg catcatgctg acaagcacgg tatcgggacg gatggctgct 2814001 tttagatctt caatagaaac aaatccgtct tcattcacag aaagataagt gatatcaaac 2814061 ccgaacaact ctttcagctg ttctaacgat tccgtaacgg atggatgttc aatagaagtg 2814121 gcaatgatat gtttgcctgt ttttatcttt gacaaagccg ctccttttaa agccgcatta 2814181 ttggcttctg tggcgcctga cgtaaataca atatcatatt tttttaggcc taaggacctt 2814241 ttgatttgat ttttggctgc ttgaagcagc tgttccgttt cggctccata tcggtgcaaa 2814301 gatgaaggat tgccaaagta tcggctgctc gtctgttcat atacgttcaa gacttcatcg 2814361 taaggcttcg tcgttgaact attatctaaa tatatcatct tttttactcc tttatgaaag 2814421 cggtacaagg tatgatattt atgttaccat aacaaaattt aatagaaaat tacgaaaaac 2814481 tagtattgac ttctaatttt tttaccatat aataagattt gttcgtttcg tcatattatc 2814541 tgacaattaa ttgacagaat attttaacat aattattagg aggatttttt tcatgaaaca 2814601 ctcactgcct gtcaaagata ccattattat tggtttcatg ctatttgcgt tattctttgg 2814661 agcaggaaat atgatttatc cgccggaact tggacaagca gccggacaca acgtctggaa 2814721 ggccatcggc ggatttttac tgacaggggt aggcctgccg cttctcggca ttatcgccat 2814781 cgcattaacc ggtaaggacg ctaaaggcct tgctgacaaa gcgcaccctg ttttcggcac 2814841 aatctttact gtcgtgcttt atttatcaat cggaccatta ttcgccatcc cgagaacagg 2814901 aactgtttca tatgaaattg gcgctgttcc gtttttgact ggtgtaccag aaagactttc 2814961 tttattaata tttacactta tctttttcgg cgttacgtac tatttagcgt taaacccatc 2815021 taaggttgtg gatcgagtcg gaaaaattct gactcccatc aaattcacaa ttattttaat 2815081 cattgttctc aaagccatct tcacgccgat gggcggattg ggcgccgtga cagaagcata 2815141 taaaggaaca ccggttttta aaggattttt agaaggctat aaaacaatgg acgcacttgc 2815201 ttcaattgta tttggcgttg tcgttgtaaa tgctgtaaaa agcaaaggcg ttacacagtc 2815261 taaagctctt gctgcagcct gcattaaagc aggtgtgatt gccgctttag gcctgacttt 2815321 catttatgta tcccttgctt atttaggtgc aacaagcaca aatgccattg gtcctgttgg 2815381 tgaaggagct aaaattttat ctgcgtcttc ccattattta ttcggttcat tgggcaacat 2815441 cgtactcgga gcagcgatta cagtcgcatg tttaacaaca agcatcggcc ttgtcacatc 2815501 ttgcggccaa tatttttcaa aacttattcc ggcattatca tataaaattg tcgttacgat 2815561 tgtcacgtta ttcagcttga tcattgcgaa tttcggactc gcgcaaatta tcgcgttttc 2815621 tgttcctatt ttatcagcta tctatccgct tgccattgtc attatcgttc tttccttcat 2815681 cgataagatc tttaaagaaa gacgcgaagt gtacatcgca tgcttgatcg gtacaggact 2815741 tttcagtatt ttagacggta tcaaagcagc cggtttttca cttggatctt tagatgtgtt 2815801 tctaaatgcg aatcttcctc tttacagcct cggcatcggc tgggtgcttc caggaatcgt 2815861 cggagcggtt atcggctatg tgctgacctt attcatcgga ccatccaaac agcttaatga 2815921 aataagttaa tgtcacagaa cgcctgcgtt attgcgcagg cgttttgtaa taaaaaaaga 2815981 gcctgctcat tacactgcgg gctctttttc atggtcgtga ttatctaagc ggatatgtca 2816041 gctttgattt tttcaactgc acctggcgca gccttttcta cagcggcagc ggcaatttca 2816101 taagagtcgt cataatcaaa agcataaaaa cgtctttccg cttctttcag ctgttcagat 2816161 aaaatatgat tctggcttct gaaccggttt ccgaactgaa tgattttttc aatgaggatg 2816221 acctgctcga caagttcctc tgattcccgg cttgccctgt tgacgatatc ttctgcttgt 2816281 ttcaaatggg ctccggcttc ttccatattt aatggaagtt cgtttagttg attgaccgtt 2816341 tcttgaatat gatgatgcgc gttctccagc atctcttgaa tatggctcgg aatgcctgga 2816401 atgttgctag tcttcagcag tcttgctgtc tcagaaattg tttttttcaa attgctgagc 2816461 gtctccctcg cctgaagctc ttcttttctc agcgcttgca gattttcacg atactcggca 2816521 tgctcttttt tcacttcttc aatttgcttc tctattgaag caacttcttc tactaaaagt 2816581 gagtaggcga catgctctgc atcaagctta tctttaacgg atgatagcag ctttccaatt 2816641 tcatcaaggc gcttttcaaa agcctgctgt ttgccgagct caccggctgt cagcctgtag 2816701 ctttccttca ccagctcagt ttccgctttc gtatgctctt tctcttcttt aagcttgtcg 2816761 taagcaataa tcaattcagg cattttgctt agtacggatt gaccggcttc aacttcgccc 2816821 tccagctgct gataaacaga ttgaatattt tcgtcaatga gctgcaggat tgcggacgct 2816881 tcatcaatat ccagttcagt catcaggaca tgttccgctc gtttcagctg gtttgacaga 2816941 ttttctaatt ccttatcaag ctggatatgc tcaagcttgt accctttttc tttcatttcg 2817001 ccatagccat ccttgagctt tgcaatctgt ccgggcaccg tctgtttaca gtcagctaac 2817061 agcttcggca catcatctat gtatgactga agccgttcaa gattgcggtc ctgctcaagc 2817121 agtacttttc gtgcagtaat atagtttccg ccttctgttt cttcttcaaa ttgtttgatg 2817181 ccgctccaaa tttcgtccag atccttttca aggctgtcat aaagctcccc gtaaaggtgg 2817241 ctgtaagcca gcaggttttt tcgagatttc gaatagcgct ccctcacctg ttcaatctct 2817301 tcacggctct tttcctcact tgtgacaaga tcgctgattt cccgaagaat cttttcaatg 2817361 cttgattcag ccgctgtcag caggtcgtcg atatgaacga gcacttgatt ggccttttta 2817421 aaccggtatt tgtctgcatt ttcctcggca tcataaagga gctcttcaac tttcggcatg 2817481 tgggctgtga caatctcatc ccattcttca cgccacttct caaagaactc ttctgtctga 2817541 cccgtcattt ttaaatgttt tattttagac atttcttcca cgatcgaccg attcagaatt 2817601 tcaatcttcc acgattccag ccggtcgatt tcggcgtaga tttttttcct gaaaaagtag 2817661 cctgccgcaa acagcgcaag cagtacaatt aataatccaa tgacaaactc cataatgagc 2817721 ccccttgctg tttaccttaa tctgtcaggg tgttttattt attcagaaag atttcaggat 2817781 atgtattgag aaaaactgtc gttttcattg ttattatgat accatgtaac aaacattttt 2817841 tgaccagaaa tcaaaaactt tttgtgcaaa atcggcagga tttgactatt ttttcatggg 2817901 gtgacatcaa tgcaaaagcg agacggacat attcacacac cattttgccc tcacggctcc 2817961 aatgacacac tcagacaata tgcagaagaa gccttaaaaa aagggttcga atcgattact 2818021 tttaccgaac acgccccatt gccgccatct tttaccgatc ccacgccgct gaaagacagc 2818081 gcgatggcgc aagcttcttt ggaacgctat attcatgaaa tttccggatt aaaaaaagaa 2818141 tatcgcggac agcttagcat acggacaggg cttgaagtcg attatatcgc tgaatttgaa 2818201 gacgaaatta cattattcct agacacatac gggccatatt tagatgacag catcttatcc 2818261 gttcattttt tgcgcacaga ctcttcctat ctatgccttg attatgacga gcataccttc 2818321 aaagagctga tttcagcctg cggaagcatt gaagcggtat atgaacaata ttaccggagt 2818381 atctattctt ccattgtagc atctctcggc gtttataagc caaaaagagt cggtcacatc 2818441 acactcgtcc aaaaattcat caagctgttt ccatacagca tgtcagagca tattcgcggc 2818501 ctcgtttctc tgtgcctgaa tgccattgaa gaaaacggaa tggagctcga cttcaatact 2818561 tccggcttaa gaaaaactta cgctggcggt atttatatcg aggattggat gctgaatgaa 2818621 gcgaagcaaa agaagatccc gcttgtgttt gggtctgatg cccatcaagc gggagatgtc 2818681 ggatatgcgt atgaggcgtt tttggaacgg tgctagttgg tgagcgccac gtctcctgtc 2818741 cggaagacgc ttctgatcca aatcttgatt tcttcaaaat acattttata aaaatacggc 2818801 tcgtgcggct gcatgtagag tacttctgaa atatattgag gctggagata gggcatcatc 2818861 aagagagatt ttaattggag aataaaatga ggcagcggca gcgttaaata ttcacgctgt 2818921 ttttctcctt cctcaatgat cagctggaag atatactttt ccttcattag atatgtcgac 2818981 ataatttccc tgattaatgt ggagtcaatt gtgacttccc ggtagacaaa acgagttaat 2819041 tgacgatgat tatgctgata ggataaaata tcgaaaacca attgaagaag ctgttcctgc 2819101 gtgctttgag tagagatatt gcttgccgct gtttcaagcg ttttgctgta gccttcgtaa 2819161 aactctgaaa ctaagtgttc catcaagcct cctttgcctt taaaatagta ggagatgtgc 2819221 gcaacattta catcagctga ctttgcgatt tcacggacag acgtgccaga aaatcctttt 2819281 tggttaaaaa gcatgacagc agattcaata attttgtctt tggtgcttac tttcatacgg 2819341 ctcactcctt cctcttgata ctattcaagc agaaagccgc tgttcctgta agaacttatc 2819401 gacaaatgcc ggcagaaaag ccggaacttt gttttatatt atagaaaaag tgagggtttt 2819461 ccatgttcca tgtcgaaaaa caatctggag ataaagaaaa agactatcag cttctgctaa 2819521 aacagctcga agccatgacc gaagacgaaa cagaccaaat agctaactat gcaaatgcct 2819581 cagcactgct gtatcattcg ctgcctgaag tcaactgggc gggtttctat tttgccaaag 2819641 aagaggatgg acagcttgtg ttaggtccgt tccaaggcct gccggcatgt gttcggattc 2819701 ctttcggcag aggggtttgc ggcacagcgt acgcaaacgg aaaagtggaa cgtattgagg 2819761 atgtaaacgc gtttccggga catatcgcct gcgatgcagc gtctcaatca gaaattgtgc 2819821 ttccgattcg tgtagacgga aaaattgtcg gcgtcttgga catcgacagc ccagtgaaaa 2819881 accgtttcga cgaaattgat gaaaaatact taactcaatt tgccgaaacg ctagaaaaag 2819941 cgttagcgca gtaatataaa agcccaaaac tgatatcgtt ttgggctttt tttattttat 2820001 tgagtcatga atcatcaagc ggtttttccc gctccgtttc gcgctgtaga gcgcttcatc 2820061 tgcctcatgc acaagctctt tcagcgactt ttttgtttct gtcgtccagc aggagatacc 2820121 gcaggaaatg gttacctcgg gtttcgtatt ttttctgacc gcgtaaacca gtcgctcggt 2820181 aatccgtttc cccactgcaa ccggcacatt tggcaaataa atcgccagct cctctcctcc 2820241 ccagcgggca ccgacatcat gctttcggat gttgctttta atcactgaag cgacttgaat 2820301 taaaatctcg tccccagtct gatggccgta cgtatcattt acatttttaa aattatcaat 2820361 atcaacaaga ataaaaacac ccttttgatg gattttcatg ctgtattgaa ttttttcatc 2820421 taaatacgct cgtgaataca gttcagtcag ctgatctgtt ttcacgagat gctcaaggcg 2820481 gtcgcgaagc attgaattgg ttacagccag tgtcgcgtga tgaatcagcg cctgaaacag 2820541 cttgtacatt tcaaatgtaa aagcgtacag ctcctgtttc aataaaaccg caaagcctaa 2820601 aagccggtcg ttttgaatca tcggagcagc catcagcgag ccgtaccccg ccttcccaaa 2820661 aacagactgg ccattcccga tgaaaacccc tttttcacct tcatacagct tttctttcag 2820721 ctcattataa aaatctgacg gcttcgcttc tttaaaaaat gctgtgctgc ctgggagcaa 2820781 tgttaggttt tcaaaatggt ctatatgaaa aaatcccact tcttctgcct gaaacgattc 2820841 tgccattctc acagccagat cattcattgt atcagtcaat gtcagccgct gattcaggcg 2820901 tcgtgatgtt tcattaatca attccaaatt tgcgatgctt gctttggatt gttcgtagag 2820961 ctgggcattt tcaaacgctt ttcccgcggc gtttgctaac agcgacattt catcaaggca 2821021 ggcatcagta agaaagctgt cacccgttcc ttcagccttc aacaccccgt atgtgccctg 2821081 ctgtcctttg atcggaatat aggcgacaga ttcatttttc cgcaaaatgt ctccggacaa 2821141 atacactttg agcgcaaagg aatcggattt ttccccttcc atatacagct cttttgcagg 2821201 aatccctaaa cattggtctt gatcgtgcga tataaataaa gaaaactcaa aaagagaaaa 2821261 tgtgcttgtc aagctttcta aaagctgctt cagcacatct gtctgatcaa gcagtgaatg 2821321 gaacagctct gtcattttgt atatcttttt ttggtagatc gttttgttat agagtctttc 2821381 ctgtttcatc gactggttta aaaatgaagc aaccacgtcc ggaagccctt caggaatctc 2821441 ttcatcctgc ctgcacgcaa gatggaaacg cctgccggag ccgtcctcaa tcagataaca 2821501 tgaagcgttt atttttgaag cggaaaaacg cgcttcacca tctgccagtt ttgtcacaaa 2821561 gtctgatggt gacggtgtaa gcgaaacaca aagggttgaa aaataggttt gaatagccga 2821621 agtcagccat atgaaagagt cggtgaatgt gactttttca gatttggtta ataaaaaatc 2821681 gagcatatga taatgaaagg cggataattg atctttagtt tgttctacca tgtttttatc 2821741 acctaaaagt ttaccactaa tttttgttta ttatatcata aacggtgaag caataatgga 2821801 ggaatggttg acttcaaaac aaataaatta tataatgacc tttgtgtgaa atattgcagc 2821861 ctttttgttc agcttctatg ttttcatttt gttccttatc aataaggtgt atcgtgtaac 2821921 tctctgctgc tggagcgagg atacatgaaa acaaaatgtg catggtcgaa tagagcagac 2821981 ggtttttatt ttccacaaaa ataaaaccaa aggaggagtc acattatggc tcgctataca 2822041 ggtccatctt ggaaactgtc ccgccgtcta ggaatctctc ttagcggtac aggaaaagaa 2822101 ttagaaaaac gcccttacgc tccaggtcca cacggcccag gacaacgtaa aaaattatca 2822161 gaatacggtt tgcaattgca agaaaagcaa aagcttcgtc acatgtacgg tgtaaacgaa 2822221 cgtcaattcc gcactttgtt tgacaaagct ggcaaactag ctggtaaaca cggtgaaaac 2822281 ttcatgattc ttttagattc tcgtcttgat aacgttgtgt acaagctagg tttagcacgt 2822341 actcgccgtc aagctcgcca attggttaac cacggtcaca ttcttgtaga cggaagccgc 2822401 gttgacatcc cgtcttacct agtgaaacct ggtcaaacaa tcggtgttcg cgaaaaatca 2822461 agaaaccttt ctatcatcaa agaatctgtt gaagtgaaca acttcgttcc tgaatacctt 2822521 actttcgacg ctgaaaagct tgaaggtact ttcactcgtc ttcctgagcg ttctgaactt 2822581 gctccggaaa ttaacgaagc gcttatcgtt gagttctact ctcgttaatc gttttaaaaa 2822641 cccctgccgc tatgcggtcg gggttttttt atcggctttc gcctcttgct ggccaacact 2822701 atcttgcgcc tgctgctccc aatgatcccg ctgcagccgt tcttttgcaa tcgtacacat 2822761 gagattcacg ctttagcgct cctttcattt aaaaggtggt gattggtcgt gtttgcccta 2822821 tctaatatac tcttttcctt tcattcctat gcggtaaaca aaaagatcct ttgccttcag 2822881 tggcaaagga tctttttctt atttatacgt cacaaggaag tattttttct tcccgcggcg 2822941 cagaacagta aattggtttt cgatgcggtc ttcacctgat agggtataat ttatttccgt 2823001 ctggcgttca ccgttaatgt aaacagctcc gttttggatg tcttcacgcg cttggcgttt 2823061 agaaggagat aatttagatt gcaccaacac atctacaagt gaaagctctt gggtgctgtc 2823121 aacttccata gaaggaacat ctttaaagcc tacttttacg tcttgagcag aaagctcttt 2823181 aatattgccg ctgaacagcg cttgggagat gttgatggct tgctccagcg cctcgcgtcc 2823241 gtgaacaagt gatgtcactt cttctgccag gcgtttttgc gcttcacgtt tttctggcgc 2823301 cgtttctgtt ttttcagcgt atgcttcaat ttcctctttt gaaaggaacg tgaagtattt 2823361 caagtatttg acaacgtcac ggtcgtctgt gttgatccag aattgataga attcatatgg 2823421 cgatgttttt tctttatcaa gccagatcgc gccgccttcc gtttttccga acttcgtgcc 2823481 gtctgctttt gtgacaagcg gaatcgttag gccaaacgct tttgctcctt cttcttctga 2823541 ttttctgatc agttcaagac ccgctgtgat gttgccccac tgatcgcttc cgccgatttg 2823601 cagtttacag tttttgtctc tgtaaagatt taagaaatca taagattgaa gaatcatgta 2823661 gctgaattcc gtgtacgaga tgccggattc aattcttgag ctgaccgtat cttttgccag 2823721 catgtaattg atgccgaaat ttttaccaac gtcacgaagg aaatcgatca cattcatttt 2823781 gccgatccag tcaaagttgt tcgcgatgac agctgggttt tctgctgctt caaaatctag 2823841 aaatctggac agctggtttt tgattttttg ggaccattcg gatacgatgt cagcagtgtt 2823901 taatgtacgc tctgcttttt ttccgcttgg atcaccgatg aggcccgtcg cgccgcccac 2823961 aagcgcaatc ggatgatgcc ctgcaagctg aaaacggcga agtgttaaaa taggcagcag 2824021 gtgtccgata tgcaagctgt ctgctgtagg gtcaaagcct gagtacaagc ggattttttc 2824081 ttcattcagc tgtttattta acccttcttc atctgtcatt tgctgaatca atccgcggaa 2824141 ggataagtct tcaagtaagt tagtcataag ataaagctcc ttttttaatt aaaataaaaa 2824201 acgccccttc gtttacacga agggacgatt gattatcgcg gtaccaccct actaataaga 2824261 gaatgcaaac attcgtctta tcactttgcc tgataacgga tcaggtccgt tctttcacta 2824321 ctgaaagcct ggccggcttt gtttgcaaaa gcggttcatg agtgtattcg atatatccgt 2824381 ctgtgctgat tttcaccggc catcagctct ctggaacgta aggatattct acttgtctca 2824441 atctttacct tttcatatga agctatatca tttttaacat aaataaaatc ctgtgtcaac 2824501 gccgcctttt aatcctccat tgttgacaga tctccagccg gcagattaag ctcccatgcc 2824561 ttcagcacgc gcctcatgat ctttccgctt ctggttttcg gaagcttatc tttaaattcg 2824621 atctcacgcg gagccgcatg ggctgcaaga ccctgcttta caaataggcg gatctcttct 2824681 ttcagtttat cagacggctc aaatccttcc ctgagtgcaa taaaggcttt aatgatttct 2824741 ccacgcaccg ggtcaggctt tccgataacg cctgcttctg caatagccgg atgttcgaca 2824801 agcttgcttt ccacttcaaa tgggccgacg cgctcaccgg aggtcatgat gacgtcatca 2824861 actctgcctt ggaaccaaaa gtatccctct tcatccatgt aagcagaatc cccagacaca 2824921 taccagccgc ccggcatgaa atacgattca tacttttcag ggttattcca aatggtatgc 2824981 atcatggaag gccagccctt tttgatggcg agattgccca ttcggtacgg cggtagctcg 2825041 ttgccttgat tgtcaacgat cgctgcctcc actcctggaa tcggcttacc cattgaaccc 2825101 ggtttaatat ccatgcaagg atagttgcag atgagctgac tgcccgtttc ggtcatccac 2825161 caggtatcat ggattcgttt gttaaaaact ttatgtcccc atctgatgac ttccggattt 2825221 agcggctcac cgacactgag cacatgccgg agtgaagtta gatcatattt cgcagccatt 2825281 tcatctcccg ctcccatcag catccgaaaa gctgtcggcg cgctgtacca gacattgacg 2825341 ccaagctgtt caatcgttcc ataccagctt tccgggctga aacgtccgcc gacgatgaca 2825401 tttgtcgctc cgttcagcca cggtgcaaaa atgccgtata ccgtacctgt cacccagcct 2825461 ggatcagccg tgcaccaata aatgtcttct tcctttaaat caaggaccca ctttcctgtt 2825521 tgatattgct gaatcatcgc ttcatggaca tgcaacacgc cctttggcgt accagtggaa 2825581 cctgatgtat agtgaagcag aaagccgtct tttttatcca tccattcgat atccaatctt 2825641 gtgctttcct gtttcgctgc ttcatcataa ttgatgatat tcgtgccgct ctcagcctct 2825701 cccccgacta cgaagacatg ctgcaagtga ggcagtttgt ctaccggtat tctctccagc 2825761 agctcaggcg ttgtgacaac aacctttgcc tcactgtttt caagccggtc tttcaccgct 2825821 ccctccataa atgcttcgaa cagcggcccg gcgatggcgc caattttgat tgcgccaagc 2825881 ataataaaat aaagctcggg tgatctcggc ataaaaataa aaacgcggtc ccctttttcc 2825941 acatttccat accgtctcag cacattcccg gctctgtttg attcttcctt catttcttta 2826001 aatgtgtatt tttcatccct ttttgcgtct ttataataaa gcgctacttt gttttttcga 2826061 aacgattcgg catggcggtc aatcgcttca tacgccgcat tcagtttccc tgtctcatgc 2826121 caagagaaat gtttctctgc ctcggcccaa tcaaaatgcc ggtacgtttc ttcatagttt 2826181 tttaagttat gatccccctc tattgctggt aacgctttca agttcatgcc caaacatccc 2826241 cctttgctga agttgtcaca attattatag tatatattca tattcttctc aatttttaaa 2826301 atataaacca tgttgaaaac gctttataat ttggtattct taaagaaggc atgtattttt 2826361 gataagaatt gatgggacgg tgaattagtg gaacatcata aaacatacca ttcagcaaac 2826421 atcaaaacag caaccggctc tttactgata gaagggcctg tctctccaga ggatttggca 2826481 ggttatgagt ttcataaaga tttaaccgca tttcgcccgc ctcgcgagca gcatgaagcg 2826541 ctagtcgaca ttgcaggcct tcccgaaggg cgcattatta ttgccagaga cggccgaacc 2826601 attgtcggct atgtcacgta tttatatcct gacccgctcg aaagatggtc tgaaggaaat 2826661 atggaggatt tgattgagct cggagccatc gaagtagcgc cggactatcg gggatgcgct 2826721 gtcggaaaga cgctcctgac cgtcagcatg atggatgaac aaatggaaaa ctacattgtg 2826781 atgacgacag aatattactg gcattgggat ttaaaaggga tgaaaaaaga tgtgtgggaa 2826841 tacagaaaga tcatggaaaa gatgatgaat gcaggcggat tggtctggtt tgcaacggat 2826901 gagccggaga tcagctccca ccctgcaaac tgtctgatgg cccgcattgg aaaaaacgtc 2826961 agccaagaat caattgagca atttgacagg ctccgttttt atcatcgtta tatgtattaa 2827021 ctgacactga caaaggggaa aaaataatga ttgttgagca aatcatgaaa agagatgtca 2827081 ttacattaac gaagacggat acgcttgaaa cagcaatatg caaactgaag gaattccata 2827141 tcaggcatct gcctgttgta gatgaagaac gacacgtgat cggcatgatt acagacaggg 2827201 acatgaaaca ggccagcccg agtatttttg aagaaaacaa acgaagccta tttctcacac 2827261 gaagcgtaga ttcaattatg aaaaaggatg ttgtctgcgc ccacccgtta gattttgtcg 2827321 aagaaatatc agccgtgttc tacgagcatg gcatcggctg cctaccagtg gtacaccatc 2827381 aaaaattaat aggcatttta acaaaaaccg atttgctgcg gacgtttgtc aaattgacag 2827441 gcgctgacca gccgggctcg caaattgaga taaaagtaaa cgacatcacc aaaagcctcg 2827501 ctgagatcag cagtctttgc caagaccttc aagtgaaaat attaagcgtg cttgtttatc 2827561 cgcatgacga tcccggtgta aaagtgcttg tcttccgtgt aaaaacgatg aatccgctgc 2827621 cgtttttgca ggcattacaa agaaatggac accacgtcgt atggccgtca gagcaaaggg 2827681 atctgctatg agagacagtg tatttatcta ttctccatcc taccaaacct atatgtttca 2827741 tcaggagcat ccctttaatc agcagcgggt tctgttaaca tatgatttgc ttaagacgat 2827801 caatgccttt gatgatggag acattgtcac ccccagactc gcttcagaag aggagctttc 2827861 ccttgtccac acggacgatt acattcaggc cgtaaagctt gcgggcgccg gaaagctccc 2827921 cgctgaagaa ggagaaagct acgggctcgg cactgaagac acacccgtct ttgccggcat 2827981 gcacgaagcg gcatcactct tggtcggcgg cactttaacg gccgcagact gggtcatgtc 2828041 aggacaagcc ctgcatgcgg caaaccttgg cggagggctt catcacggct ttcgcgggag 2828101 agcatcagga ttctgcatat acaacgacag cgctgtggct attcaatata tccagaaaaa 2828161 atatagcgcc agagtgcttt atattgatac ggacgcccac cacggggacg gtgtgcaatt 2828221 tacattttac gataatcctg acgtatgcac gctgtccatt catgaaacag gaaggtattt 2828281 attccctgga accggtcaga tccaagaaaa aggaagcgga aaaggatatg gctattcctt 2828341 taatattccg cttgacgctt ttacagagga tgattctttt cttgaggctt accggacagc 2828401 agcttcagaa gtcgccgcgt atttcgagcc cgatgtcatt atcagccaaa acggcgccga 2828461 tgcccattac tacgacccgc tgacgcattt atcagcaaca atcaatatat acgaagaaat 2828521 cccccgtctt gcacacactt tggctcatca atattgcgga gggaaatgga ttgcagtcgg 2828581 aggcggcgga tatgatattt ggcgtgtcgt gccccgcgcc tgggccagaa tatggcttga 2828641 aatgaaggga attgacccgg gtcacgagat cccgccggaa tggattgtta aatggcaaaa 2828701 acaatgcccc gtggcccttc cgtcgagctg gagcgatccg gctgatttat atcctccgat 2828761 tccccgcaag cctgaaatta cagaaaaaaa tgcccaaact gtcagcaaag cattatatgc 2828821 gatacgttct gaacagcaaa gaacaaagta aaaaacgacc tttacgaaga ggtcgttttt 2828881 gattttttaa tcactatttc cacacgccga ttttccttca tgtgttcatt tgtcttgtta 2828941 tcctttactg gctttgtatc cgcataaccg acagcaataa agcgcttgga gggaagcttc 2829001 tctttagacg tgaagtattg aatcactcca cttgcccgtg ctgctgatag ctcccagttc 2829061 gacgggtatc ggtatgtcga aatgtttcgg ctgtctgtat gtccctcaac ctgaatgtca 2829121 tttggaattg tttgaagaag aacggcaatt tggtgaagaa gtgtttcggc atttttcagc 2829181 acctttgcct cacctgtatc aaacagcaca gcctcctgaa gaacgagcac gacaccgcgt 2829241 tcatcccgtt tggctgtcat ttgggccttc aaatgattgt cttttatata tgtatttact 2829301 ttcttgagaa gctgatcctg ctgatcctct tgcttcttcg tatcagatgg ggatgtattc 2829361 tttttttcta tggatgtttg gtccggctga agcccgttgc cttccttctg gatcgagtcc 2829421 actgccgctt tgaatttttg cagatcgatt tgggacatcg aaaagagtaa aataaagaac 2829481 acaaggatca aggtgatcag atctgtaaag gttaccatcc agctggatga agattgactg 2829541 ttttttccgc ttccattcct tctttcaaaa cgttctcttc taagcttcat gtacagatcc 2829601 cttttttgtt tttacttgtt ttggctgctt ctgccattct tcccgtgagc tgaaaacgac 2829661 cagctggctt tcaaggttgc gcgggttttt tccggattga acaccgataa tcccttccac 2829721 cattacctgc ttgatgaaaa tttcactttc tgttttctct tcaagcttag ccgcgatcgg 2829781 gttgaagacc atatttgcca gtaatgaacc atataaagtc gtcagaagcg caatggccat 2829841 gtttggtccg agcatatgcg ggtcgtttaa gtttttgagc atcagcacaa gcccgacgag 2829901 tgttccgatc attccccatg ccggagcgaa ttctcccgct ttttcaaaaa ctcgccgccc 2829961 ttttcggtgc cgttcctcca ttgctgcgat ttctgaatcc atgacgagcc gaatcgtttc 2830021 ttcatcccag ccgtcaatcg ctaaaagcag cccttttttc aagaatggat ctttgatttc 2830081 ccgagcctga tcatccaatg ataaaagccc gtgttttcgc gcgtgatcgg aaagggaaac 2830141 aaaggttttc acaagatctt tcacattgtc ttcctggcgg atgaatgcct gctttaacac 2830201 agagggcgct tttttcagct cacttggcgg aaaactgata aaaacagcgg cgcaaagtcc 2830261 ccctgttacg atgaagaaag aggtcagatc aagaaaagag cggaaaccgc ttactcccga 2830321 tcctgaaata atcccgataa caataataat cgttcctaac acaaatccaa caggtgtaag 2830381 ataatcaaaa cgtttcatca tttctcccca tgaaaaaagc aagaattcac cataaaggtg 2830441 aagcttgctc tttgtttttc ttatgacttg gttgactttc taagctctat acggtgcggc 2830501 agttcgacga tatgctcttc aaccggctct ttattcatga gcttcgtcag cagtctcatc 2830561 gcaacggcgc cgatatcata tgtcggctga acaactgttg aaagctgagg acgaaccatg 2830621 aggcttaatc ttgtattatc aaaaccgata atgtcgagat cctccggaat ggataagccc 2830681 tgatcctgag cggcatggat aatgccgagt gccatttcat cagttgcaga aagaatggct 2830741 gtcggttttt tatccaggct catcagatgc tgcagtgctt cgagtccgga atcatatgtg 2830801 taatcccctt cagctacaaa ttgttcatta aacggaaggt tcgcttcttc aagcgcacgt 2830861 ttgtagcctt ggagtttttt cgaacggttg atcggttctg ccattggtcc ggaaacgaac 2830921 gcgatgtctg tatgtccttt atcaaccaaa agcttcacgg catcataaat cgcctgttcg 2830981 taatcgatag cgactgacgg tgtttcctcc tgctcttcta cagaagcggc aagtacaatc 2831041 ggcactggag aacgcttaaa ttccgccaca tgctcgtccg taatgtttcc gcccataaac 2831101 acgatgccgt ccacttgttt gccgagcatt gtgtttaaca agtgcagctc tttctccatg 2831161 ttttggtcag agttgctcaa aataatattg tatttataca ttgtcgcgat atcttcaatt 2831221 ccgcgcgcaa gctctgaata gaaaatgctt gagatatcgg gaatgatgac acctacagtt 2831281 gttgtttttt tacttgccag ccctcttgcc accgcgtttg gacggtaacc gagacgttca 2831341 atggcttcca agactttttt cctcgttgtc ggttttacat tcgggttgcc gttcacgaca 2831401 cgggaaacgg ttgccatgct tacattagct tctctcgcta catcgtagat cgtaatattg 2831461 ctcatcctaa aaccactcct tttactggat acacttatcc ttatctatag cataaacact 2831521 ttatgtagag aaatgtcata atgtccgaat ttatgtcgtt tatgatttgt aagcgtaagt 2831581 cagtagtgta cattattttt cattattcat caaatttaat tacttctcat gaaattatac 2831641 acgtttttat agatgatgaa aacgtatact tggtttttat aactaaataa acgagaaagc 2831701 ataaaaaaag gccgcaggcg cggccttttg gattgttcaa ttaagcgttg actttcacca 2831761 ttggcttcag ttcattcagc catttttcga attcaggaat cgccatttgc tgagcagagt 2831821 cagaaagtgc gactgacgga tcagggtgaa cctcagccat tacgccatca gcaccgatcg 2831881 ctaaagcggc tttagctgtc ggaagcaaga ggtcacggcg gcctgttgaa tgcgtaacat 2831941 caacaaagac tggcaaatgc gtttcttgtt tcaaaatcgg cacagctgaa atatccagcg 2832001 tgtttctcgt tgctgtttca tatgttctga ttccgcgctc acaaaggata atttggtcat 2832061 ttccttgtga catgatgtat tcagcagcat tgatgaattc agagatcgtt gcagcaagac 2832121 cgcgcttcag aagcactggc tttttcacgg cgccggccgc tttcagcaat tcgaagtttt 2832181 gcatgttgcg cgctccgatt tgaatgacat caatgtagtc cagcgcttct tcgatatgag 2832241 ccggagttac gatttcactg ataaccgcca gatcaaattc atccgctaca cgttttaaaa 2832301 tttgaaggcc ttcaacacca agcccttgga aatcgtatgg gctcgtacga ggcttaaagg 2832361 ctccaccgcg caaaatttta atcccttgtt ttttcgcagc tgcagcgact tcagctacct 2832421 gctcatagct ctctaccgca catgggccga caatgaatct ttgctggccg tctccgattt 2832481 tttcgccttt gatatcaaca attgtatctt caggtttttt cttgcgggag acaagcagcg 2832541 ctttgctgtg atcttcttcc tgaagctcta aaccggcttt gaatatctct ttaaaaatgt 2832601 gctggatggt tgaattttcg aacggcccgt cattgttttc aatgatattg tttaacattg 2832661 tgcgttctct gacagggtca aatcggttga caccctgtgc ttccttcgct ttaccgatct 2832721 cttttacaac attgccgcgt tcgttgatta attttaaaat ttgtaggttt aattcgtctg 2832781 ctttctgcct taaaagctct aactctgtgt tgctcatttt tttcatcctt tccctgcaca 2832841 ttcatttttt attttgtagt tatcatgcat cttactataa gtaattccaa atggaaatac 2832901 tgaaatacaa aaaattttat aaaaactcta ctttattacc caaacgcttt taagtgataa 2832961 agtaatctat gaagctatcc tacatgatgt gagggcaatg ttcaagggtt ttttacaaaa 2833021 aaaagcgcca gatgatatct ggacgctttt ttctatgaca aatgctgctc aatagcggct 2833081 tctgtaattt gtgaatgtga ggtatgccat ttcacttcac cgttctggat gatgaatatc 2833141 tgagggcttt catgcttgac cccatatgtt tctgcaatga aattggacag cggccgggct 2833201 tcttgtactt gaagatagta agccggcaca tcctcatgct gatttgcaaa ggcatcaaac 2833261 tcatgaaatg ctgcctggct gatcgggcat gtggtgctgt gtttcaagaa gacgaaaacg 2833321 ccttcctgtt ctgcaatccg tttaaattct tcctcagatt gaataagctg tttagccatg 2833381 actcaagctc ttccttccct gctcagcgat tcaactgctc agcctgtttt tgtgcatctt 2833441 tcagttcgtc ttttacatct tctttcgtct ggaggacttg atcttttgtt tcatcagctg 2833501 cctgcatcgc ttcttccctc atatcttgca ttgcagtcga tgaatccgtt ttgtcagatt 2833561 tggaacggtc tctcaaatcc tttaccttgt tcatgatctg tccagactga tccgctacaa 2833621 gctgtgtgat gttggaagtt ttgtcttttg cgatgctgac atattgcgtg cctttttcct 2833681 tcgcatctgc cgtcatttta tcagttttgt cccgtaaggc aacagcctgg ctgccgagat 2833741 cgtcgcgaag ttctttgcct gatttaggcg ctagaaaaag agctgtagtg gcaccgatga 2833801 ttcccccgat taaagttccg attaaaaaat ctttactatt aattccatct ttgctcatca 2833861 ttattcctcc tcttagtatt tttttctctt acagggctga ttttttcttt tgcttccatt 2833921 tctcccaaat ttccattgct gcttgactcc aagtgacaac ttgattgatc ttatcttgat 2833981 tctctctaac tgatgccgat acagaccctg ccgcttgttt catggatgta ttgaactgct 2834041 gtacagaagc tcccactcct tgaacagcat gaacgaccgt gttcagcttt tctgattttt 2834101 cctgaatatc ttcagccagg cggttggtct tatgtaaaag ctcggctgtt tcagttgtga 2834161 tgcccttcat ttgtccctcc agcccttcaa gagtggatgc gacgtttttt agtgtcagct 2834221 gcagtgactt caatgtttta gacaagtaga tcactaatac gagaaatgca actgcgatga 2834281 gtgcaacgct caaataaaga ataataatca tctcaaacct ccttgctgca ggatatactg 2834341 ctgtttaccc gttttcttca atcataaaca tgtgtactgg gctgtataca tactattctc 2834401 cgttatgtaa gaaaatcctt taataagctt tcccatcaga taaataaaaa gcagtgagat 2834461 cactgctttt tattatgcca tgacgttttc gtaggctctc atatattttt ggatatctcc 2834521 tgctcccatg aagatgagaa cggctttatc atgagctttt aaaacagatg tgtcatcttc 2834581 ttcaatcagc ttggcattat gaatttttcc ctggagatca ccgatcgtca gctttccggc 2834641 attctcacgg gctgagccga aaatatcgca taaatacaca cagtcggcgc cgctcaggct 2834701 ttctgcaaat tcgtcaagga actgctgcgt ccgggtaaat gtatgaggct ggaataccgc 2834761 gacaatttcc cgatcaggat acttctgtct tgccgcctcg attgtcactt ttatttctgt 2834821 cggatgatgg gcatagtcat caatcagcac ttgatcccca agctgcttct cattgaatct 2834881 gcgtttgacg cccccaaagg atttgagagc atgcttaatg atgctggaat caatttcttc 2834941 ataatggcat aacgcaatga ccgccaatga gtttaataca ttgtggtggc cgtacgcagg 2835001 aatataaaac gtatcataga acgtattgcg gacaaagaca tcaaaagttg tcccttccgt 2835061 gctttttacg atgtttctgg cttgaaaatc attttcttcc cccgtgccat aatacacaac 2835121 cgggacgttc gcatggattt tcggcagatg ctcatcgtct ccgcaggcaa taatgccttt 2835181 gttgacttga agagccatct cttggaaagc gtcaaataca tcgtcaatgc ttgagaagta 2835241 atcagggtga tcaaaatcaa tattcgtcat aatcgcataa tctggctgat agcttaagaa 2835301 atggcggcgg tattcgcacg cttcaaacac aaagtattcg ctgttttcat ttccctggcc 2835361 tgttccgtct ccgattaaga aagacgtcgg ttttgcgttt tggatcacgt gagccagcag 2835421 acccgtagtc gacgttttgc cgtgtgcgcc cgtaacggca acactcgtga attttttcat 2835481 gtagtcgcct aaaaacttat gataacgtat caccggaatt ccctcagaca tcgctttttc 2835541 tatttcagga tgcgtgtctg ggaatgcgtt tccggcgatg actgtcatgc cgggtttaat 2835601 attttccgcg ctaaaaggaa gaatcgtaat atttcttttt tcaagcgctg tttgcgtaaa 2835661 aataaatttt tcgatatccg atccttggac agtatatcca ttatcatgaa gtatttgggc 2835721 aagcggactc ataccggtcc cttttattcc aacaaaatga taaacagtca taattgtacc 2835781 tccaacaaac gtctatctgt tccccagtat atgacgctca tttcaatttg cgaccgcggc 2835841 ggctgaaaag cctcccttag cggcgtattt tatatgtttt gttatgttta gtatcaggtt 2835901 atttctttcc gattaaaccc agatatcaag atttgtctat gcacagctgc tgtaaagcgg 2835961 catagctgtt aaatgctcta aacactatca taccatgttt ggtgtgaaaa tgaacccata 2836021 ttattcgttt attaaatcac ttgctgtgat cagcacctct cgaggcttgc ttccttttgc 2836081 ctcagagatc atgccttccg cttccatcat gtcgatcagc cttgccgcac gattgtaacc 2836141 gattctgaat cttctttgca ggcttgaagt gctcgcactg ttttgctcta caacaaactc 2836201 acacgcttcg taaaacagtt cgtcctcttc tttcagggca gatccttgtc ttacgagctc 2836261 ttcttgttca aataaatagg tcggcggcat ttggcttctg acgtgggaaa cgacgcggtc 2836321 gatttcccgg tctgacacaa agttaccttg cagacgaacc ggttttcccg agccgttttc 2836381 caaaaagagc atatcccctt ttccgagaag cttttctgca ccggctatat caataattgt 2836441 tcgggaatca acctggcttg agacagaaaa ggcgattctc gttgggatat tcgccttaat 2836501 cagacctgta atgacatcga ctgacggacg ctgagttgcg acgagaagat ggataccgca 2836561 cgctctggct ttttgggcga tccgcgcaat gctttcttcc acatcgtttg gagccaccat 2836621 catcaaatct gcaagctcat caataatgac aactaaatac ggcagctttt cacccatttg 2836681 gtgttcagcg gttaattgat taaagcggtc aatgtcgcgg acacctgaat gggcaaaaag 2836741 ctcatagcgg cgctccattt cctcaacgac ccatttcaaa gcagccgtag ccgctttagc 2836801 atcagtaatg accgggctga cgaggtgagg aattttattg taaggggcca gctctaccat 2836861 tttcggatca atcagcagca cctttacctc actcgggtca gctttataaa gcaggcttac 2836921 taatattgta ttgatgcata cgctttttcc ggagcctgta gcgccggcaa tcaagccatg 2836981 cggcattttc ttcaagtcga taacaacagg atttcccgaa atatctaatc ccagcgcagc 2837041 tgtgagcggt gacttgcttg tcctgaaagc tgagctgcga atcatttggc gcaaatcaac 2837101 caccttgctc gtgcggttcg gcacttcaat tccgatcgtg tttttccccg gaatcggcgc 2837161 ttcaatccga atatctttag ctgagagact gagtttaata tcatcggaca agttggtgat 2837221 tttattcacc tttacacccg gttcaggatg cacttcaaat ctcgtgacag acggaccctg 2837281 ggttacatgg accacattgg cgcggacatt gaaatttttc aaggtcaaat caagaagctg 2837341 acgctgttct tcgatccacg cagtatcatc ttgaacctgc gctggcggga catcaagcag 2837401 tgcaacattc ggaaatacat agctgccgcg gcgctcctct gctttttgct gtttatgcgt 2837461 atctcttttc agcatcatca cattaaaagg aacggatggc cctttttgag aagatgcgct 2837521 ttgttcagtc cttttctcct gtacaccagg cctttttttc ggctcttctg aagcttcgcg 2837581 aggtttgtct gcgcgaattt cctgccggtt ttcaagagtt gcagtagacg atttggaacc 2837641 ctgctccatg tgttcagttt tctcaagctc tgtatggctg tctggctgaa catctatctt 2837701 cgtttcctga gcctctccca gggtgtcata atgattattt attatgcttt ctgatggctc 2837761 ttctgattct tttgccacag tttctgcttg agccagagcc tctgatgaat actcatgatc 2837821 agtaaataaa ggctcttcct gacgaatgtc catttgttct tcttgaacga acggggactc 2837881 agcaccttct gccgcgtttt catgatgatt gtatactggg ctgtctgacg gctcttttgc 2837941 tttttcatcc tcagatactg cctctgtctg agattcagga gctgtttgct cttcatcaag 2838001 ttcagcggag aaaacaggct cttcaaattt ctctggctgc tgctcccttt gttcttcctc 2838061 agccgttgca ggctcttcgc ggcctacttc actgtctgaa agcccttcag ccgccgtatc 2838121 tgtgagcatc tcaggcggtg tttgctcttc ggcttgttca gctgggaaga aaggctcctc 2838181 tttttccggc tgttgaacgc ctgactcaaa tggcactttg ttacctgacg gctcggctgg 2838241 ccgtttcgcc agcgcctcat catgctccgt atcctttctg tttaaaacgc cagaaggctg 2838301 tttttcaaat tgggtatccg ggaagaaagg actttctatt ttggaatgcg cctgtgtgtc 2838361 tgaagcagga tagccgcgtt cacgttcgat ctcttctgac agcagtgtta ccttctcttt 2838421 taccgattta tccggttcgt tcaatgtttc agaaggcttt ttcggcacat cctttttaac 2838481 agatggtttt tgattgaatc catagacagg cgaagggata tttgtcggtt taaacggttt 2838541 cttcgccggc tctgctgctt gatatgtatg ctgctcttct tcatttctgg gacgctctct 2838601 gtaaggtgca gcacttggac gaggcgcgga tttcggttcg tccgatggtg tgcggcgcct 2838661 tctcaggtca tgatttttgt atccgtcagg cacgactgga aaacggaatt tgccttttgg 2838721 atattcataa tatattttag gatcttccaa tctttttaat tgtccttcag gatgatgtac 2838781 ttcttgttgc tgcggaattt gagcgggttt tgtctcccgt tcagcatcct cttcgctttc 2838841 gcctaaaaac aaatcaaaaa atttatgaag ccaactcata atttatctct aactccctta 2838901 tagttttctg ggacggtttt tagtatacca ctgctggtcg gcccagaaaa gattaagcta 2838961 tcagcagaaa caaagccgct aaacaagggc ttagcggctt ttcacatgat tcgttttttt 2839021 tggcggattt atgggagtct aaaactgaaa tgcgtctccc gcctcatagt ctccttctaa 2839081 cacaaggatt cctttttcag caggggcatc cggcaaatca agctctttcg ctgagcagat 2839141 catcccgctt gacggaacgc cacgaagctc tgcatcctta atgacaagtc cgctaggcat 2839201 cacagcaccg actttggcaa cgacaacttt ttggccttgg tcaacgttag gcgcgccgca 2839261 gacgatctga agcgtttctt ctcctacgtt gactttacat acgcttaatt tatccgcatt 2839321 cggatgtttt tcttttgatt ctacataacc cacaacaaac ttcggagata aatcaacgac 2839381 taatgtttct tcaacgccgt ttctgtttaa aatctcattc acatcttgca cgaatgtttc 2839441 tgagagcgca acagggccgt tttcatcaat ggtcaagtaa gaagacgcat tgaaaatgtt 2839501 gaagcccgtt gtttcttttg tttcgttatt gaaaattttg acgacgtcgc cgtgtttttc 2839561 atagcctaat tgttcgcgtg tcacatcttg aagagagatc aggagcgtgt ctcccacacc 2839621 ttctttatta taaaaagcgt tcataagtaa aaatcctttc taatcctttt tcggacggct 2839681 tttcgccagg ataaacaccg gttccagctt tccttcattg tacaaaaatg atagggcggt 2839741 aatcgggacg gtgccgcctg caaagaagct catcgacatt tgtcctagaa tatcataccc 2839801 cgattcattc cggatgtcag caagaatcaa aacgtcctga tgaggaacag agatcgccag 2839861 ctcaccttct gcatgctgct tatactcatt taagatcgct tcgttcaaaa tccggcttgc 2839921 gtcgtatccg tcgtttgccc tgaagaaata aaagtaattg ccggcaaccg tatcctcttt 2839981 gacaaccgtc ggcagggaac ggagattaaa tgcggccgtc tctctgatcc gctcttttgt 2840041 ccagttttct ttctcaagca tgcgctggtc aattaaacgg taggttttcc cgagatctag 2840101 cgcgtaataa attcttgtct ctgcggtatg atcgtcataa atgagcggga tatcttcgct 2840161 ggacttgtcc gggaaggaag tcgagcggat gaccggataa atgcgagttt ctttcccggt 2840221 catttcctga gccttccctt ccattgccgt catcgcttcg gagacatagt acacgatctc 2840281 atcaatggct tcgtcttttt tcagttccca ttttgcaata atcggcggca aatcgagtgt 2840341 aatccctttt ttagtcgttt gatcctcaac acggagggtg tctttttctc tgtcaaacag 2840401 aaaggagcga ttctcgtgct gaaggcgctg cttcagtata tctgacagct tccttgaggt 2840461 cattttcaaa ccgatgtcct cctttacgct ttagcgagag agtctgttaa aaactgttca 2840521 atttcttctt ttgttttgcg gtctttgctc acaaaacgat ttacttcttt tccttcatta 2840581 aacaccacaa agcttgggat tccgtaaatt tcccactctg cacatgtatc aatgaatttg 2840641 tcacggtcta cgtagtagta ggtgaattca gggaaattcg cttccagttc aggcaggaaa 2840701 ggctctacaa aacggcaatc cgggcaccaa tcggccgaaa acataaatac agaccaatca 2840761 tcctttaccg ctttttccag ctcttgagtt gattcaattt ttttcatttc atatccctcc 2840821 agttgtttat gttcttacat gttttttatc gatactcgtc catttggatc ataccaaact 2840881 gcttgaggca aaaccactta tatgcaacga atgaatatgt aagattggct ttcccattat 2840941 cattatcata ttttatttgc attatcaagc tcgtttcgtt taacatcgtg tacatgaggg 2841001 tgaaatttac agatggatat acataaggag ggatttttat tatggagttt atcgtctatt 2841061 tagcaggaga aatccacagc aattggcgcg aggaaattaa agaaaaaaca aaatcactga 2841121 agctcccgat tacgtttgtt ggcccgatgg agaatcatga ccgctcagac aatattggtg 2841181 aagaaattat gggcgtacag ccaaatgccg ttttaaagga tgacaaagcc tctgacatca 2841241 acaacttcag aaccgccgtc ctgatgaata aagcagactt tgtgatcgcc ctgtttggcg 2841301 aaaagtacaa acagtggaac acggcaatgg atgcatcata tgcgatcgca aaaggaaaac 2841361 ccctgattat catccggccg gaatcgctcc accatccttt aaaagagctt tccaataaag 2841421 cgaatattac ggttgaaacc gttaaccaag ccattaaggc cctttcctat ctatttgaaa 2841481 cagaataaga aaaaagcttg tcgatccggg cttactgctc gttcaacaag cttttatgaa 2841541 acctacatat tttctttaat cgcatccact gtctgcttat cgcaggctgt tacaagtttg 2841601 atgagcattt ctttagcagc agcataatca tcaatatgaa tgatagtagc gtttgtatga 2841661 atatagcggg aacatattcc gataaccgct gacggcacac cgctgttcga aatatgaacc 2841721 ttgcctgcgt ctgttccccc gccggataca aaatattgat atggaatatc atgcgtttca 2841781 gccatatcaa gaacgaattc cctcattccg cgatgcatga ctgtcgttct gtcaagaatg 2841841 cgcagcaaaa agccttttcc aagctggccg aattcatttt tgtctccgct catatcgttt 2841901 gccgggctgg cgtcaagggc gaaaaacaag tccggtttaa tcatatgaga agccgtctgc 2841961 gcgcccctta gccctacttc ttcctgaacc gttgcacccg catagagtgt attcggaagc 2842021 tctttaccgt gtaattcctt cagaagttca atgcttaagc cgcatccata tctgttatcc 2842081 catgcttttg ataaaatttt cttttcattc gccatcgtcg taaacggaca aacaggcacg 2842141 atctgctgtc ccggtctaat gccgattttg atggcgtctt ccttatcatc cgctccaatg 2842201 tcgatcatca tgtttttgat atccatcggt cggtttcgct gcgcatctgt caataaatgc 2842261 ggcggtatgc ttgaaatcac acccggaacc ggcccgttat ctgtttgaat ttcaacccgc 2842321 tgcgcaagca aaacttggct ccaccagcct ccgagcgtct ggaatctgag cagcccgttg 2842381 tctgtaatgg atgtcaccat gaagccgact tcgtccatgt gcccggctac cataattctc 2842441 ggtgcgtcct ctgcgcctcg tctgactccg aaaacacttc ccagtctgtc ctgaacgatg 2842501 tcatctgcat atttggctag ctcctgcttc ataaaagcac gaacctgatg ctcattgccc 2842561 ggcgcgccgg gaagctgcgt cagtgtttgg aaaagcgctt tcgtttcttg attcatgttt 2842621 tcccctcatt tctatgtagt ccttttattt tattagaaac aatgaagttt tccaagcact 2842681 ctgacccaat ctgctcgatc agccgcgtat tgcttaacag gatttggctg tttctgtata 2842741 atgaaaagta cgatcaacca ggaggtgctt tattttgaaa ttgcgtcatc ttcttttagg 2842801 agcaggactt ggaatttgta cggctgtcgt tgtgagacaa tatgtgatga agccttatat 2842861 ttcttcagaa aaagcgcttc gaattgtaaa atctgctttt aagcagcggg gcccgattga 2842921 cggatcatgg atttacaccc agccggagcc ctacaatatt aacggagaaa cggtacaggt 2842981 atacaaaacc ggcattacac gatcagcttt cggagaatta gaacagtatg aagtcatggt 2843041 ggatgcgaaa acgggagaaa ttgttgatgt cattgataca atcgcctctt aacaccggac 2843101 aagcaaaaaa tagaagccgc tgcctatgca gcggctcttt tttattatat cgcgcgaatc 2843161 ggtttgtata ccggatacca catcgcatcc tgcactgcct gtataatgtc ttcaggctct 2843221 tccgtagcga cgccttcctt cattgcggtt tttgcaactt caacagcaac ggttgccgaa 2843281 acagtgcgca aatcttcaac ttttggaagc atcggcgccc caggcacccc gacattgacc 2843341 atacctgcga ttgcccgggc acatgcttca aacatgccgt cggtaattaa ttttgatttt 2843401 gtaacaatcg ttccaagacc gagaccaggg aagacaagcg cgttgtttgc ctgcccgata 2843461 tgatacgtaa ctccgttata ttcaactggc gggaacgggc ttcctgtcgt gatcagcgca 2843521 cggccttctg tccattcgat taaatcctcc ggctttgctt cagaaagagt tgtcggattt 2843581 gacattggca aaatcgccgg ccgtttcaca tgtgacgcca tttcttttac aatttcttca 2843641 gtgaaagcgc cggaaaccgt agatgtgccg atcaggatcg tcggtttcgc ctgccgaacc 2843701 acttcaagaa gatcaatgcc tccgccgtct ccgttccgct gataatcctt cacttcatca 2843761 gccgaacggg catacggctt ttggaaatca agaagctgat ccatatcatc tgttaacagc 2843821 ccgttcctgt ctatgcacca gaagcgcttg tatgattctt cttcactcag tccctcgcgc 2843881 accaatgctt cccgcagctg ttcggcaatt ccgattcctg ccgttcccgc tccgaatata 2843941 acaactctgt gatctctcag cggaacttta gacgcttttg cacaggataa gactgcggcc 2844001 aaagaaacag cgccagttcc ttggatatca tcattgaagg tacacacttt atctttatag 2844061 cgtttcaaaa tgcttcgcgc gtttttcgcc ccgaaatcct cccaatgcag caatgcattc 2844121 ggaaatgttt ctctcgccag cgcaacgtag tcgtcaataa attggtcata acgttccccg 2844181 cgcactctgg aatgctggtt gccgacataa agcgggtcgt tcaagaggct ctcctgattt 2844241 gtccccgcat ctaaaacaac agccagcact ctgctcggat caatgcccgc agccgctgta 2844301 taaaccgcca gcttgccaat agaaattgcg attcctccga cgccccagtc accgattcct 2844361 aaaattcctt ccgcatcagt tgcaacaatt aaatcgatcg tatcgctttg atctttatac 2844421 tgtttaaaag cttctttcat accgtccggg tcatcgattg acagatagag ccctcgtggt 2844481 tttctgtatt catggctgta tctctgaatt gccgttccga ctgtcggtgt gtagacaatc 2844541 gggagcattt cccctaaatg gtcatttaac aggcggtaaa acagcgtttc attccgatcg 2844601 tgcagcgccg ttaaatagac atttttgctc aaatcgtcag gctgtgcgga atattgttca 2844661 tacgctcttt tcgcctgatc atcaattgtt aataccttgg gcggcagaaa gccttttaaa 2844721 ccaagttctt ttctttcttc ctcagtaaaa gcaacacctt tgttcaaaaa aggaacagag 2844781 agcacttcaa ggcctcttaa tgttgtttga atgtctcctt cgtttgttac tctgaattgt 2844841 ttcaccctgc ctcttccttt ctgagcataa tagtactagg tttgcattat tagccggaaa 2844901 acatgcaggg taaacataaa aatatgctat cgcttcattc gcttaactga ctttttgatg 2844961 cttccgtcct cctcccattg aagggcgcga tactcggcat catggtaaaa aataaaccaa 2845021 gcatcttttt ctgctgcgaa cgcctgccat ttctgctttt gcgggataga ggtcatcgga 2845081 taatcatcgt aagccagcac ccatagcgga ttgcggtggg catgtgtcgg catcagatct 2845141 gccatatgta cggcagtttc acccgcatcc tcgcatatca ggacactgtg tccgtcgcta 2845201 tggcctccgg tgtgatgcat tgtaataccc tctgtgatcg ttaaggtgtc ttcaaaggtt 2845261 ttgacttggc cagctacagc ctcccaattt tctttccaat acgtattttt cgacctgata 2845321 ttcggatggc gcatttcgtc ccattcaaca gctgatgtat aaatcactgc attcggaaag 2845381 acagagacga gccgttcacc ttcatattcc gttaaaccgc atgcatgatc aaaatgaagg 2845441 tgtgtcattg cgatcacatc tatatcggca accgttaatc cgagtgcagc taatgagggt 2845501 ttcacattcg actcttgtgt cacgccatag tttcgttttt gtttatcagt cagcttgccg 2845561 tacccaattc cggcgtcaat gatgatattg agcccatcct tttgaatcaa aatagggtct 2845621 gttcttagtt caatctggtt tttttcattg actggatatt ttttagacca aagcggcttt 2845681 ggcacaacgc cgaacatggc gcctccgtcc atatgcgtca cgcctccgtc aagccaggtc 2845741 aacgtgatgt ttccaatttt cattgtttcc attttcaccc ccccctatca tcatggtagc 2845801 aaacggccca taaaaaaaac agactcctgt cagagtctgt ctttacgttc tccattcaac 2845861 ctcagcccga tagatcggct ggccgagtgc agagaatttt tcttcatatt ctgtcataat 2845921 attgccttcc agattgctgt tatgcaaatc gagactgacg tatgtcagca ggaggccgta 2845981 ctcagagaag ctcttcaaag agtactcaaa taaacctcgg ttgtccgttt taaaatgaat 2846041 cgatccgcct ttgcccatta cttcttcata ttttttgagg aagtgggaat atgtcaggcg 2846101 gcgtttttca tgccgtttct tcggccaagg atcagaaaag ttcaagtaga cccgtttcac 2846161 ttcccccggc tcaaacacat ccgtcagcgt gtccgcatct atattcagaa gctttacatt 2846221 ctgcgcttcg ctgtctttta ctttttggac ggctgtcacg atgacgcttt taaataactc 2846281 aataccaata taattgatgt cgggattttg tttggccata ccagaaataa attggccttt 2846341 tcctgtacca acctcgatat ggatcggatt gtcgttgcca aacactgtgt tccatttccc 2846401 tttataatca gcaggattgc tgatggcaat atctgcgttt tcagccaaaa agtcatcagc 2846461 ccaaggcttg tggcgcattc tcatatgatt gacacctcta tctattattt cgactaacaa 2846521 cataccatga attaaaaaga cccgcaagct cgtttttcca gtgtatctct cttaaggccg 2846581 agcgcataaa aaaagagggt cccgtctgct ggaacactcc tttcccatgt ataaaaacgc 2846641 tctgttttga acaatttaac ccgtatgata ctgaagggat gtgtaccgtt atgggtttac 2846701 attatgagca tcaagttcat ttattgaagg atatattgac tgaccatcaa ttggactgct 2846761 gcggaacagt cgcagagtac gagcagcttg agcgtgtgat taaatcactg atggcaaaca 2846821 ccgagcttga ttcaaatttc aaaaacgtgc ttgaagatgt ttaccgctac agccaatcag 2846881 gaatatcgtc caaatccatc gactcacaca tacaagagca tcagaacagc ctgtctcaat 2846941 gggtagagca aatggattcg tattcctgat taatcaacaa ttcgtttcat gaggatatgc 2847001 agctcttcca ttgcatcatg aaattcctta tcattgcctt ttgctttatg ccaggcaatg 2847061 aaagtaattg tttcagataa cacataccaa gccattcgca accgaaggct ttctgtcagc 2847121 tctatgccgt acatgctcag ccagctctcc caagctggct tttcgacgta gtggtacagc 2847181 aaaggcccga ggtccatcgc cggatcagcg atcatggcgc cgtcccagtc aattaaatac 2847241 agctggttgt cttcagacaa tagccagtta ttatgattga catcacaatg gcaaacgact 2847301 ttctcaccga aatgcacttc atgcaggtgt tcttccaaat acttgatccc ttcttgaatc 2847361 agcggcgaag attgctgcac agcaaataca gcctgcttca gctgagacaa aagagccccc 2847421 gggttcagcg gttcttttcc aagtctcttc agcatgtcca gcaaggcttt tgatgtgtgt 2847481 attttacgaa gcaattcagc aacgggccgt ccgctcatgt ctttaggctt cagctctctg 2847541 ccggtcatcc agtgctgggc cgtaatgacg tccccatttt ccatccgttt tgtccaaacc 2847601 agcttcggaa caatgccttc ggcggataaa acagctaaaa aaggtgagct attacgtttt 2847661 aaaaaaagct gctgcccgtt atgtttcgca taatatgcat ctcctgtagc tcctccggcg 2847721 gggaagatct cccaatcgct acctagtaat tgtcccaacc agttcatatc aatgttcaac 2847781 ccatcatttc ttaaaatatt ttagaattaa ggctaatcgt ttctagtcta tccagcgaat 2847841 gcctttttcg tacgaatcgt ataaaaataa aaaagacagc tattgagagt ctcatatgct 2847901 aatcaatagc cgtcctttaa attttagcgc tatagcacaa acttcgtcaa gcaaaactct 2847961 taagatctga tgctaaatat aagataaccg ttccgatgcc gtttactgca accgttttct 2848021 tgatttctgt tgggtcttcc tgaaatcctg atggatcaca taaaagccga taaggtatgt 2848081 cgtttggcag cctccactcg acggagtctg gactcgcgtg atggataaca atgatatctt 2848141 tccattcgtc aacctcgtca agatcataaa gcctgtatgc gataaggtgt tcttttagcg 2848201 tcaagcattc aagatggcgc tggatgtctg cagcggacct aagacggaat gcaggatgcg 2848261 cttttctcag cgagatcagc ctgcggatat agtgaacatc ttctttgaat gtttcacggc 2848321 gatcccagtc gagctggttg atgctgtcac tggattgata gctgttttcc actccctgct 2848381 tcgtccggaa aaattcctgg ccgctgtgaa taaacggcac cccttgggca agcaaaataa 2848441 tcgcggctgc aagcctttgc ctgcttcgct ttcggctgtc attttcttga ggaagcgcaa 2848501 agctcatttt atcccaaaag gtgtgattgt cgtgtgattc gacataattg atggactggc 2848561 ttggttccgg aacaatcggt gctaatgcct tccatccgga agacccggca attccatgca 2848621 tcacagcttg tgctgattca ccgttgccga gcgcaaaccc tgttgcctta aggtgaaagg 2848681 tgttcccttt tacagcgtca cgaaacatat cattaaaaaa gccgatgccc ggcattcttg 2848741 gcgcgttcgc caaagcagct ttctgttcat gcggcagcgg tgtagccagg tcccaccctt 2848801 ctccaaaaag caggattccg ggctttgcct tagttgcttt ctctttcata taaagcacgg 2848861 tgtcaatatc taaaatcccg aggagatcaa agcggaagcc gtcaacattg tattcttcaa 2848921 gccaatagac cacgcaatcc gcaatgaatt ttcttgccat ccttctttct gatgcaatat 2848981 cattgccaac gccggtgccg tttgatggca tcccacattc gtcgtgccgg aaaaaataac 2849041 cgggcactgt cttttcaaag ggggaattct ccctcttata cacatggtta aaaacaacat 2849101 ccagaatgac tcgcagaccg tgctgatgca gggtattgat catttgtttc agctctgttt 2849161 ttctcgtttg aggatcatga ggatttgagg catagcttcc ctccggggca aagaaatgaa 2849221 gcgggttata tccccaattg tatgcatcaa gcggcttctc ttcatcaact ccggcaaaat 2849281 cattcaccgg cagaagctcc acatgtgtca caccaagctc ttttacatac gctaatcccg 2849341 aagaactgcc atttgcggtt tgtgtatcag tttccgtcag cgctaagtat tttcccttgt 2849401 ttatcatgcc gctgttttca tggatggaga agtcgcgaag atgcgtctca tagatgacgg 2849461 catccacagg gtgtgagaat ggtttaagag gagcagtcca tttcatttga tccgggcgca 2849521 agacgacgcc cttctctcca tttacagtca cagccttggc atactggtca actgtttcca 2849581 tccattctga attgttgcag atgcaaaaca aatactcata tccgtgaagg tcacctgtga 2849641 ccgtaacggc atagacgcct ttttccaagc gagtcatttg gaatgtgcgc ccgcttttat 2849701 tggggtgtga aagcttgaca gcagctgagg ttgcagcagg cgcccatact ttaaatacgg 2849761 tatgatccgc ggtataaacg gcgcccagct ctccgtcata ataaaattcg tcatcaaacg 2849821 ctgccgtccg gatgaccgcg ccaatttgga gatccgtttt gtggccgctg gatgctctga 2849881 cgcaatggat ttttccaaat gtcacaggat ggtcggatac gcagacgtac ttgtattttg 2849941 cttcaaggga gtattcctcc ctgacagcca gaggaaaatc tgttatttct gtctcaagcc 2850001 gaaacggcgg tgtcatgatt tccttttgtt cagcaggaat cagaacagta atgatattca 2850061 tgtcatcgac atacgcttcg aagctgcggc ggatgctgac catcggaagc tctctcctcc 2850121 aaacacgttt atgttttgat tcttaggggt gaaggactag atgccagacg aaacggggta 2850181 gtgcccatga tttctccgtc agcatggaac gggattttgt ccttcgtgta aaatgtaatg 2850241 tccttcgctt taaacatcgt aacgccatcc atctttgtat gttttccaaa tgccatgaga 2850301 cataaaagcc aatatttttt caaaaacggc tggttttcaa cgattacgat atcaaatgtc 2850361 ttctcgcgcg gatttgctag gggcgccgcc ttcatgcctc ccccgtaaaa cggatggttg 2850421 gatacaacgg caaaccagac atcatgaaat tcgcgcgtct cgtcttccgt cgtacaagct 2850481 aatgtaaacg gcttaaaggt tgccgaagcg tgcaaatgag aaagcggata cacaagaaat 2850541 cgaaggcgga gaaaaagaaa aacccgtctc aacggaaatt ccatcgcctt tttattgaca 2850601 tatgcgtcaa acccgatccc gatatgattc ataaaataaa gaatctgtga tttatcctga 2850661 aggaaattga cgctccctaa atgaaaggtt cttgttaacg ggcgctttac cttcttgatt 2850721 tcctgtatca gatcgatttt tttaatagag aaccctcgcg aaaaatcatt atacgcgccc 2850781 gccggcacaa agctcagctc aatatcgtca acatctttca gcccgttgac aacttcatgc 2850841 atggttccgt ctccgccaat gacgatcagg cgcttcagct tatattcctg tatcgttgaa 2850901 atctgtctgg cgagcacctc ggcgtgtccc ggatgttcag ttaaaaatga acggtgctca 2850961 acctttcgtt tgatcaattc tttttgaatg gacttccaaa cacgcaggcc gtttcgatgt 2851021 cctgctgtcg gattaataat aaaaaaccaa tggctcatct ttctcacctg cttatgttat 2851081 gagaaaaccg ctcaaatcgt tctcttttac tccagccact cctgtctgcg ataggagtca 2851141 gacatgcagt aagacaatag agcctttgca gcctttacct gatgatgttt gatcggagca 2851201 gtgtttttct tctgccgctc aatccattct tccgcgctcc gcttatccgc tatttctaag 2851261 ccgtatggcg gctccgggta atcgatgtac gacgttctgc tcagaagcaa ttttcgaacc 2851321 ggaatctcag cctgtttttc ctttacgatc tttgacacaa ccgagtccgt acgaaacagg 2851381 ctaagccctg gatttaacac tgatgcagtc tgagaggctg ttttcttgtc ccaaaaacga 2851441 tttttagacc ctatgtagac actgtcttcc tcagcctcta aaaaagaaac gcaataaatt 2851501 tccagaggag aaataatcac aatgcttaat tcaaccgccg cctgctgaat tttcagcaca 2851561 ggcttataca taataaaata agaatcaggc agctgctggg tcagataacg caaaatgcgg 2851621 tcctgcttca cttggtttga gagttgagat atttctgaaa gagtagagct tgcccatttg 2851681 agctgaaaat catataaatg ccttttataa aaagaagcaa gcgccaccct gctcttcggg 2851741 agccttacat gaatatcttc ttcgtcctca aaccattggt gtctctcttc ttgtatatcg 2851801 gcttttatct cttcttttct tcttttcaat gaaaattttt ttcgtttctg caccggttcc 2851861 ggttcttcag cactggcttg cctttcttca tgctggcgct ccgctgcttc tactagtgaa 2851921 agccagcgct cttttttcaa acgtacaaac tggttgatat aatggtacgg atcaagctca 2851981 tatctcgata tataatcatg aattttgatg atttgtgcca tgtttgtttc tccactccgc 2852041 aatgaattaa gataattgaa atttgaatat ttcctcgtat tttggtgatt ggttcaagtg 2852101 tatttgaaag agcgaaaatc gttcagccat catcgaaacc tcgccgcttt caaacggaac 2852161 atgagctgga aatccatctt cgcctgtcca ttttcttgcc agcgtcatat gaggatgata 2852221 cggtcttttt tccacttgaa agccggcctg aagtacagcc tgcttcgtat gttcccgcag 2852281 tctatcaagc gttttgtttt tctttggctc cagatgtaaa acgcgcggct ttctgcggtc 2852341 gccgaataca tctatcttgc caaacttaat tgaaaatgga tcaatttctg aagcaatctc 2852401 tgctagcgaa ccttcaagct tctttatttg tgtctcatcc gccgctccga gaaaaattaa 2852461 cgtgatatga tagtcaagcg ggtgcaccca tttttgaaac gtcaatatcg gttcgttttt 2852521 cgcagcctgg tagatcggat ttgcaattcc ctcaggtatg ggaacgccga tgaaataatg 2852581 aggccgtata tctggcatcc gtctgacact cccttctttg acagctatta ttttatcaat 2852641 aaagaggctg tgcggataga ggaacagtgt atgaaaacac tctcgcacaa acgtttatta 2852701 tgttaggata ttatatgaca cttgttttat tcagaaagga atgacaatgt tgaaaatcgt 2852761 tgcaaacaca gctgatctga taggagatac accgctagtg agattgaatc ggcttcagcc 2852821 ggaaaatgcg gcacaagtct atttaaagct tgaatttttc aatccgagcg gcagtgtgaa 2852881 agacagagcc gcttatcaaa tgatcataga agctgaacaa aacggtttac tcaagccggg 2852941 atcagttatt atagagccga caagcggaaa taccggcatc gggctcgcca tgaatgcggc 2853001 agcacgcgga tataaagcaa tcttagttat gcctgatacg atgacgaagg aacggatcaa 2853061 cctacttaaa gcttacggtg cagaggttgt attaactccc ggagaggaaa gaatgccggg 2853121 cagcatcaaa aaagcgaagg agcttgccga acaaattccg aacagctata ttccaatgca 2853181 gttcgataac actgctaatc ctgatgcgca ccgaaaaaca acagcgcctg aaatcgcccg 2853241 ggcaatagag gaaatcggaa aaccgctcgg cgcttttgta gcctcctctg gaacgggcgg 2853301 aaccattacc ggaacaggtg aggcgctcaa agagcttttt ccggatatca cggttcatgt 2853361 tgttgagcca gcgggttcgc ctgtattatc cggcggaaaa cctggcgcgc ataaacttgt 2853421 aggaacgagc ccaggcttta taccgccgat tttaaatgaa gacgtttatg atgaaattat 2853481 caaaatctct gatgaagacg cgtatacgac gacaagacgg cttgctgctg aagaaggaat 2853541 tcttgtcggt ccttcatcag gcgctgcctg cttcgcggca atcgaaacag cgaaacgcct 2853601 ctctcctgac aaagttgtgg tctgcatgac agctgataca ggagaacggt acttatcaac 2853661 tgatttatgg tcatttattt aaaaaaagga ctggcttcag cagaagccgg tccttttatt 2853721 ttgcaagctc gtaaatggcc tgagcatata acgctgtcga tctcagcagg tcatcaattt 2853781 cgatatattc atccttttgg tgtgcgctgt cagggcgtcc ggggaacagc gggccgaacg 2853841 cgacaccggc ttttaaggat ctcgcataag tccccccgcc gattgagatt aaatcagctt 2853901 ttttacccag ctggccttca taaacctttt gcagggtttt gactaacgga tgatctgcgg 2853961 acacgtgatg cggcttgctg tctttgaatt ctcccagctc aaattcagat gcgctttcga 2854021 atgtatcgcg gatcactttg ctttctgctg tcacaggata gcggatattg atcccgagct 2854081 cgcctccttg cccttcttta tagcgcagtg ttccgacatt taatgtcagc tctccgctga 2854141 tttcatcctc acagtcgatg tccagttttt ttcctcttgt atcacctgag aacttatctg 2854201 tcacaacttg cacaaaccgc tttcctgcat cgtcaagctc agtctgctgg agaaattcgc 2854261 acaataaaat gccggcattg atcccattgt tcggttccat cgcatggcag gaaagaccgt 2854321 acatacgcaa aatgagctgt ccgttctcta ttgcagcttc ccctttttgg tccgtcgtgc 2854381 ggagcatgtc tttaaatgaa gacagaatct cttcattttt cggcccttca atgacagctt 2854441 ccgcagcgtc gggcaccatg tttaagcgaa ggcctgattg aaacgagaca agcactgcct 2854501 ttggttcagc ttgatttggg cggtgcggaa taagtaaaga agcatcgatg atcccttttt 2854561 ccgcattaat gatcggaaaa tcggcgtcag gcgcaaagcc cattgttggc atttcttcat 2854621 gcttgaaata atgctctacg catctccaat cactttcttc atctgttccg ataatcattc 2854681 tgactcgctt ggacaggggc aaattcatgt ctttcacgat tttcagcgcg tagaatgccg 2854741 ccattgtcgg gcctttgtca tcaatggcgc cccttgcata aatccgtccg ttgcggattt 2854801 cagctgaaaa tggatcactc gtccacccat ctcccggcgg cacgacgtca acatggcaaa 2854861 gtacgccgat aatgtcatcg ccctcccccc attcaatatg acctgcgaag ccgtcaagat 2854921 tttttgttgt aaagccttct ttttctccaa gctccagcaa tgaagtcagg ctggcattta 2854981 ccccttctcc aaacggttta ccgggtccgg cggttgtttc gtccatgaca ctgttgattc 2855041 tcaaaaattc ctgtgtatca cgaattaaat cctctttttt tctgatcact tcaacttccc 2855101 agttcataat gatccccttt ccgcaagaaa tgacttgcaa aaaccaaata aaacgaataa 2855161 tattaatggt gttttgttaa aacgttcgta attggaggat actatgtttc atctaaaaga 2855221 gcagcaaaca tccataaagc aagaaatcat agcagggctg acgacctttt tcacaatggt 2855281 ctatatcgtc gtggtcaatc cggtcattct ggctaacgcc ggggttcctt tcgaccaggt 2855341 tttcaccgca acgattattg cctccattgt cggaacgctg tggatggccc tggcagcaaa 2855401 ttatccgatt gctattgcgc ccggcatggg cttgaacgct tatttagcct ttcatgtcgt 2855461 aagcgcaagc gatggcggca tcacgtacgc aacagctttc agcgcagtat ttacagcagg 2855521 ggttctcttc attattctat cgttaacgcc tttaagaaaa caacttatag aagcgattcc 2855581 aaacaattta aaatacggga tcacaacagg gatcgggctg tttattgctt ttatcggttt 2855641 gcgtcaagcg ggaattgtgg cagctgatga gtcaaacctg gtcactctcg gcaatctgca 2855701 ttcacctggt gttatcttaa cgctggtcgg ccttttgatc agcgtggtcc tgatggtgct 2855761 gaatgtaagc ggcgctttat ttatcggaat ggcagctacc gctttgatcg cctttttcac 2855821 cggtcagctc catttttcaa agggatttat gtcgcttcct catttgccgg aaggattgat 2855881 gatctcaaat ccatttaccg cttttggcga tgtcattcat cacggcctgt acgctgtcgt 2855941 cttttctttt ctattagtca ccatttttga tacgacaggc acgatgatcg gagttgccga 2856001 gcaagccggg ctgatgaaaa acaacaagct gccgaacgtg cgaaaagcgc tgcttgctga 2856061 ttcaaccgcg acgacagtag gagctgtttt cggcacaagt ccgacgactg catttatcga 2856121 gtcttccgcc ggtgtcgcag ccgggggaag aacggggctt acggctttga ctgtcgcggt 2856181 gatgtttgcg gcttcaatgt ttttcagtcc gcttgtcagc gccttgtcag gtatagccgc 2856241 catcacctcg cctgctttga ttatcgtcgg cagcctgatg atgggctcag tttccaatat 2856301 gaactggaaa gagatggacg aggcatttcc tgcgtttctc gtcattctag ccatgccttt 2856361 gacctcgagc atttctacag gaatcgcgct tggctttatt tcgtacccaa ttgtaaaagc 2856421 ggcgcgggga aaatggagag agattcatcc gctcgtcatc gttttcgcca ttctgttttt 2856481 catccagctg tttattttat aaggatagac caaaaaaccc aaacgtcgcc gtttgggttt 2856541 tttatgtaaa caataaagag acagcggccg ctaaaaaaca acaggcggca aacgcatagt 2856601 gcaggatgtt gatacagctt tttctggccc gataatattc atcactttcc ttatcggtgc 2856661 caattaaaaa aggggcatcc atgaccttgt caaaaataag cgtcaggata taacggcaaa 2856721 cccctgtgta taccagcagc gcaatcacct tcagccaaat tggggaaaca aatatgagaa 2856781 cagtgaaagc tgacagtagc atgtacatct gccttgcata ctcgccattc ctcagcataa 2856841 ctttaaaaaa caactcctta tagcctgtgc agatcgttcg tcttttaaat atcctttttg 2856901 aatttcggta taataatggt tttcttctca tcctgtcttt tacttttggc attcccgcct 2856961 cctgactcat catcatcaca agtcctgcaa gggcaagcct gctttttttc tcttcagtca 2857021 cctcagcttc aaaagccgtg aacgaggctg tctttttcaa actgcggata actgagaaaa 2857081 acaaaaataa aatgccaaaa agcgcaagca agtgccgctc agtaaaaaca atcaggatag 2857141 cagaaccagc aaaaagaata gctctgacaa gggtatcgcc aatccatctc gaaatggagc 2857201 gcggctttct gatcctgtct tgctttaagg ataaaaagaa tatatgaagg ccaaacaaat 2857261 aacacaatag agcagtgctt tctgcgaatg tgatgagaac agaatgactg atcaagggaa 2857321 ggacaatgaa aaagagaagc agccatttag ccagcgtggc cagaaaagaa tacaaaagcg 2857381 cataccgttt gagctgatag atgatttcct tcttttgcag caaaaacact ttgtccgctt 2857441 ccattaaaaa tgtacgaatc gaacctgtaa acatgatcag cacacacaca gcatacagcc 2857501 atctccattc cgccacttca gaccactcat aaagaaggcc tcttccgttc atcaaatcaa 2857561 tatactgata gatgacaaaa gcaatcgccg gcaaaacgat atagagagcg actgtccagt 2857621 caatgaccgc atgcaacact ttaaactgat acttataata gtcaaacagc cttcgaaaaa 2857681 agagcgtacg cccgttcata gccgatcacc ttgaactgcc ttataaaaac agtcaagcaa 2857741 tgactgcccc tctaatccgg tcttgtcctg aacatctttt aacgtgcctt ggagaaataa 2857801 tgaacctttc tcaatcatat aaaaccggtc acagattttt tccgcggtat cgagtacatg 2857861 cgtgcacata agaattccgg ctccacgttc tttttcagcc ttaagcatgt ccacaaagcg 2857921 tttcgtcgat atcggatcaa ggccgataaa cggttcatca atcacataca tatccggctt 2857981 agagagaaag gcctggataa gcattagttt ttgctgcatg cccttcgaaa aggtgacagg 2858041 cagctcatgt ttgacatgat ctagcgaaaa cgtctgcagc aggctttggg cccgatgcgc 2858101 aaattcactc tcttcaatgc cgtgaagtgt gctgatcaga tccaaatgct cccacagcgt 2858161 cagttcttcg tagaaggacg gatgctccgg aatatatgca aatgaacagt cgttccaggc 2858221 aatatgccct ttaaaatctt ctgaaaggcc gagtatcgcc ttgattgcgg tgctttttcc 2858281 tgcgccgtta gctccgatca gtccaaccag ttcccctttt ctgacttcca gaaaaacatc 2858341 ggtgagcact ttttttcggc ttgtataccc ggcctgttct attgaagctt caagcaaatt 2858401 tgtcaaaact cactcacctc caaaatttac tacgaaatag aataaaaaaa gtttctttaa 2858461 ccataataat attgagccga aatacatagt aatccaacaa ggatggctgc ccaacgcgaa 2858521 attggaaaaa attaatagga gttatcccta gattcatcac tgcaatatcg tgtataatga 2858581 gggcgaatta ttttaacaat tacagatgtc tgcctttgtt gctatttcgt acgcagttga 2858641 tagtcgtgag ttgtggttag tcaagtccat ccgatcttat gatagggagt ggttttttga 2858701 aaccttcaac aaaccgtatg ctaactcgaa tcaaatcagt ttacatgttt attcaagaaa 2858761 aaggtcttgt gacaacacag gaactggttg acgaattcgg cattacacct agaacgattc 2858821 aaagagactt aaatgtgttg gcatataatg atcttgttca tagtccaagc cgtggcaagt 2858881 gggagacaac gagaaagaaa gtaaagatta cctcataaat tgaaaattac atagggccgc 2858941 ctgagagcgg tccgatagat aacagggcga agaaactact gagccttgtt tttgtgtgct 2859001 tataaataaa accccgcatt cggtatgcgg ggtttttgtc atgcttgcgg ctcatttagc 2859061 aaatgaagct cttcctctgt cagctcacgg tattctccgg gtgccagagc gggatctagg 2859121 gaaacgcgtc ccatcgaaag ccgcttcaga taaaccactt cattgccgac tgcctttgcc 2859181 atttgcttga cctgatggta ttttccttct gtaattgtca gatatataac ggtattgcca 2859241 ctgtcgtttg ttttgatttc cgcttttgcc ggctttgttt tatagccgcc ctctatgtag 2859301 acacccgttt ccaaatcgga aatgtcttcc cgagaaatct gtgattttaa atggacttca 2859361 tacgtttttg gaacatgctt tttaggagaa aggagccgat gtgcgagctg gccgtcattt 2859421 gtgagcagca aaaagccctc tgtatcttta tcaagcctgc cggctggaaa tggctcaaat 2859481 ctcatctcct ccggcgtcag cagatcgacc actgtttgct gccggctgtc ctcagtcgcc 2859541 gacagcacgc cctgcggttt attcatcata agataaatga actctcgata atcaaccggt 2859601 tccccgtata cggtcacctc ctgcgtatca ggatcaacgt gctcctttac atctttggca 2859661 ggtttgccgt cgatcatcac ggctccagcc ttcacaacgg ctttgacttc ttttctggaa 2859721 ccatacccgc tgttggcaag cagcttatca agtctcattc ccaatctctc ctttataaaa 2859781 gaaagcccgc agcatgcgag ccctcagttt catcatatct agttcatcag cctgcatgtc 2859841 tgcctttcct aaagaaacct ggcaaacggc ggcctaaaat tttctgcaaa aatcctaatc 2859901 ggtagccgca atacaggtag acagctccgc caacagcggc cgcgatcacc acaacaatcg 2859961 cagcttgcat ctggccatcc tgataggaaa taaagaagcc taatacccac tgcacgattt 2860021 tcacggcaat acccataatg gctgataaga ccagcatcaa aacagttcgt ttaacaagta 2860081 tcttatacga atagcctgca tggcgcttaa tcatgataaa cccatataaa agggaagcga 2860141 tatatccaag cgccgtcgct aaaatcgctc cgtcagcctg catcagcttg atcagcggaa 2860201 cattcagcac aagcttgatc acgacaccga tcacaaggct gacaaccgca aatttttgct 2860261 tattgatgcc ctgcagaata gctgcgttga ctgtaaacaa agagaacaga attgcgacag 2860321 gcgaatacca aagcaaaatg tttgccccca gttcaggatg aaggctctct gacccgtaaa 2860381 agaacgtata cgtcggtcct gacaatagag agatcccgac aacagccgga ataattaaaa 2860441 acaggatcgt ctgcatcgtt tgattaatct gctgatttaa cagcttatag tttccgcttg 2860501 taaacgattc agtaatcgtt ggaattaatg tcagtccaaa agcagttgct agggaaaccg 2860561 ggatcatcac gagcttctga acatacaggg ttagaatcgc aagcatgtcc tggctgatgg 2860621 cttgatgacc ggcttcaatc atcgctttgt taaacgtatt tgtatcaata tagttataca 2860681 aagggatggc tagtccgaca aaaacgtacg gagcagcata gctgaacagc tcgaaaaaca 2860741 ttttcttgta gcttaggttt gctgtcggac ccgtattcgg catcatcgcc agcaggctgc 2860801 ccttccgttt gttccaataa atataaagca cgaccagccc tccgaaggca ccgatcagcg 2860861 ctgcgaaggt tgcatagccc acagcgatga caaggccgcc gttgaaaacc ttcaaaatca 2860921 agaatgtcgc actcaataga aagatgatgc ggacaatctg ttcaacgact tgggaaacag 2860981 ctgtcggacc catcatttgg tgcccttgaa agaatccgcg gacaaggctc ataatcggta 2861041 cgaccaaaag cgctaagctg accatgcgga tgacataaac gacatgatca attgtcaggc 2861101 cgttattatc cttgcctccc agcgatattt ccgcaaacat cggagccgat agatacagaa 2861161 tgaaaaaggc tatcattcct gtgactagca taaccgacat gcccgccttg agcattttcc 2861221 tgcttgtctc ataatcccct tttgaattat atttggaaac aaatttagaa acagcggccg 2861281 gaaagcccat cgtagcaata ttcaaaaata aagtgtattg gttgtatccg tattgaaata 2861341 atgcaccgcc tgtcgccccg accataatgc tgaagggaat taaatagacc atccccagaa 2861401 tccgcgatat atatgtaccg agcgttaata caaacgtgcc tcttaacagt ttgcttgaca 2861461 tgtttcttca tcaccatttt ctacgaagat tcaacttttc tattttacca caactgggca 2861521 tttagacggt aataaataca aaagcaatcc tgtgaacatt catgtccgcg gcaaaagacg 2861581 tttaaggagc ggctttcttt cgctataata gtactgcgga cgggtgtccg cacacgaaat 2861641 gaaaagaaag ttgatgataa agatgaaaca atatgacgta atcgtaatcg gcggaggccc 2861701 ttcaggcttg atggctgcga ttgcagcagg agaacagggc gctggcgtgt tgctgataga 2861761 taaaggaaat aaattaggac ggaaactcgc gatttccggg ggcggccgct gcaatgtgac 2861821 gaaccgcctt cctgtggaag aaattatcaa gcacatcccc ggcaacgggc gttttttata 2861881 cagcgcgttt tctgaattta ataatgagga cattatcaag ttttttgaaa acctcggcat 2861941 tcaattgaag gaagaggatc acggccggat gtttcctgtg accgacaaag cccaaagtgt 2862001 cgttgacgcg ctgttaaaca ggctaaagca gctccgcgta acaatcagaa cgaacgagaa 2862061 aattaaatct gttttatatg aagatggaca ggcagcaggg attgtgacga ataatggcga 2862121 aatgatccat agccaggcag tcattattgc tgtcggcggt aaaagcgtgc ctcataccgg 2862181 aagcacggga gacggctatg aatgggctga agccgcgggc cataccataa cagagctgtt 2862241 tccgacagag gttcccgtca cttctggcga accgttcatt aagcaaaaaa cacttcaggg 2862301 cttatcacta agagatgtag ccgtcagtgt gttaaataaa aaaggcaaac cgattatcac 2862361 acataaaatg gacatgctgt ttacccattt cggcctctca ggacctgcca ttctcagatg 2862421 cagccaattt gtcgtaaaag agctgaaaaa acagcctcaa gtgccgatca gaatcgactt 2862481 gtatccggat atcaatgaag aaacgctttt ccaaaagatg tataaagaac tgaaggaagc 2862541 accgaaaaaa accattaaaa acgtgctgaa gccttggatg caggagcgct atctcctatt 2862601 cctgctcgaa aaaaacggca tctctccgaa cgtatcgttt tctgagctgc cgaaggatcc 2862661 tttcagacaa tttgtaaggg actgcaagca gtttactgtc ctcgcaaatg gcacactgtc 2862721 gcttgataag gcatttgtca cgggaggcgg ggtatctgta aaagaaattg acccgaaaaa 2862781 gatggcttct aaaaaaatgg aggggcttta tttttgcggt gaaattctgg atatccacgg 2862841 ctacacaggc ggatacaata ttacctccgc ccttgtcaca ggcaggcttg cagggctaaa 2862901 tgccgggcaa tacgcccgtt cttaatcatt actctttaaa tctcttgccg ccaaactcac 2862961 atttgaacat tccccgcatt catgttaggg tgagacttgt tttgtttcac ctgattgcgg 2863021 ggtaatttta agagaggaat gagctgccat cgtacgacca tactaagcct gcgagcaaga 2863081 tataggcgta cacaaaaaat tagagggtga gaaatgttga aacatatatc tagtgtattt 2863141 tggattgtga ttgcaatcac agctgcagct gtattatggg gtgttatttc tcctgacagc 2863201 ctgcaaaatg tgtctcaatc ggcacaagca tttattaccg attcatttgg ttggtattat 2863261 cttttagttg tctctttgtt tgtcgggttt tgtctctttt tgattttcag cccgatcgga 2863321 aaaatcaaac tcggaaagcc tgatgaaaaa ccggaattcg ggttattatc atggtttgcc 2863381 atgctgttca gcgcaggcat gggaatcggc ttagtattct acggtgcggc tgaaccgatc 2863441 agccattacg caattagctc tccatcaggt gaaacagaaa ccccccaagc cttcagagat 2863501 gcactccgct atacgttttt ccactggggt ttgcacgctt gggccattta tgccattgtg 2863561 gcattatgca ttgcctattt ccaattccgc aaaggcgcac ccgggttaat cagcagcaca 2863621 ctgtcaccga ttctcgggga taaagtaaac ggaccgatcg gaaaggccat tgactgtatt 2863681 gcagttttcg ccactgttgt cggggtgtca acaagtcttg gtcttggcgc aacccaaatt 2863741 aacggcggtt tgaattacct gttcggcatt ccgaatgcgt ttatcgtcca attggtttta 2863801 atcattattg tgacagtgct ctttttactt tctgcgtgga gcggactcgg aaaaggaatt 2863861 aagtatttaa gcaacacaaa catggtattg gccggattgt taatgttgtt tatgctcgtt 2863921 gtcgggccta cagtgctgat aatgaactca tttacagatt ctatcggaca atacattcaa 2863981 aatatcgttc aaatgagctt cagactgaca ccgaacgatc ctgaaaaacg cgaatggatt 2864041 aacagctgga cgattttcta ttgggcatgg tggatttcct ggtctccatt tgtcggcatt 2864101 ttcatcgccc gtgtatccag aggccggacg atccgcgaat ttttaatcgg cgtcttggtg 2864161 acaccttgta ttttgacatt tctatggttc tccattttcg gcgtatcagc catggatctc 2864221 cagcaaaaag gcgcgttcaa tgtagcaaag ctgtccactg aaacgatgct gttcggaaca 2864281 cttgatcact atccgctgac aatggtgaca tcgatccttg cattgattct gatcgcagta 2864341 ttctttatca cgtcagctga ttcagctaca ttcgtgctgg gcatgcagac gtcgtacggt 2864401 tctttaaatc cggcgaattc tgtgaaactc agctggggta tcattcagtc cgccatggcg 2864461 gctgtgctcc tatattccgg agggcttgcc gctttgcaga acacagcgat tctggcagcg 2864521 ctgccgtttt ctatcgttat cctgctgatg attgcctctc tctatcaatc gctctcaaaa 2864581 gaaagaagag agatcaaaaa agcggagaaa ctcgataaac caagaagtcc aagagtgaaa 2864641 aaagcatatt aacaaaaaag atctttccgc gcctgcggaa agatcttttt atttgcgata 2864701 taaaataagg gcggaaaaac agtaaagctg ctcgccgtct gggtcgcacg ccgccgaaac 2864761 cgtatatttg atatctatca gctgctcctc cgatatccct tttaaaaatg aattgatttc 2864821 cgtttgtaag tctttttcat gctcttcatc aaataccgct accttcagca ttttatccgc 2864881 tctcctttct ctatcaatct attccgtttg gaacagcgtt atgatagaga aatgatgatt 2864941 atctcgtttc cggataaaaa gctttccgta tatgggattt cctctgtggc tcgccgccgt 2865001 gctgctccac tttcagcagc acggcataaa caatgcgcat atggcagtag ctgataaggc 2865061 tgacgctgaa aaaagggaca atgcccggca ggtacgcaag caagaaaaag agagcaacag 2865121 tcagcgcaag catagtaagc gtatattgca aatacgccac actgagcaag agcgaaaatt 2865181 tcacatacag acgttttttc cagtcaaaat ggacaagcag cggaaacaca taaaaaagca 2865241 tggatacgaa caaaaagcca aatatcataa tggcgaagcg caggatgtgc agaaggaaat 2865301 gacttggata aattaaggcc aaatcaatat aaatgatcac tccgatgagc gccagtacag 2865361 cgccgagcag atttgaacga aaaaattcac ccttgtattc ctgccaaaac gttttgagca 2865421 ccggaacgtt gtcctgcccc tggatccact tccgcatgac agcgaataaa gccgcggtcg 2865481 cgggcatgat gccaaacacg ccgagaccga gcaacgtaaa aaacagccac agcaagtttg 2865541 tatacgcaaa tctcataatc cattcgcaaa aacgcagcat ccgtcccagt gagccatcat 2865601 gttccatggc gccccctcct tttttgcatt atacattctg catctgaaaa agctctttca 2865661 tgccgatcgg cttcttttcg gcaaccgagc gccacattcc ctcaccaacc gcgatggagt 2865721 aggctccagc ttcagccccg gctaaaatat catagcggcg cagcgggtct ttccctaaaa 2865781 aaagatcctc aagcaaaagc ggatcacctc cgccatgccc cccttcattt ttgaccactt 2865841 gtatcgtctg ctttgattca aaaagcggat agtattcgat tgtctgctca ggaaaagcaa 2865901 acggaattct ggaaggttcg tgaaattcat ttgattcaat acgtcctttt gtgccgttga 2865961 tcgtcagccg gtagccttca tacggggccg aaaaaataat cgagtagctt aacagtgcgc 2866021 cgccatcata tttgactgcc gccacgtacg tatcctcgat gtcaatttcc tcgtcaaaaa 2866081 tacacgcgtc aggcctgtat gcagtatata agctggactg gtctcctgct tcaagatgat 2866141 catcctttat agaagcttta gaggaacggg gatgccacct tgaatagtag tggcattttt 2866201 ctttaacacg gcacgtcccg caaaaacgcc cgtcttcttc cggcaagggg ttccactcac 2866261 tgtccggccc atagtaattc aaggcgccat aagcaaatac ctcttccgga ttttgcccga 2866321 gccaccaatt gacgagatcg aagtgatgtg ttgatttatg gacagaaaga ccgccggaaa 2866381 actgtctcga cctgttccag cgtttaaaat agctggcgcc atgatacgta tcaatatacc 2866441 aatttaaatc aacagaagtg accctgccta tttttccgtc cagaatcatt tcttttattt 2866501 tccgatgaaa cgggctgtag cgatagttaa acgcgacggt gacttttcct tcgcttttgg 2866561 cctccgcttc aagcacccga ttcgcatcct gcactgttgt caccattggt ttttcagtaa 2866621 tcacatctgt attccactga aggcttttta caatatatgc gacatgcgta tcgtccctgc 2866681 ctgccacaat gacgatatca ggctttgaga cgcgcatcat ctcgtcaaaa gcatcttcgc 2866741 taaactcagg cacgtgggcc agctcgggaa atttcttctt gcaaacggca aaacgtttcg 2866801 gatcggcatc cagcaatccc gtaatctcat aatgagttga aaaccgctcc atcagtggtt 2866861 tgataaacat actgaatgct ctgctgctca atccgcaaaa gacgatgttc ttcaatatcc 2866921 tcacctctat cgggcttcag ttagttgaga aatcagctgc agcgcttcct ctgttttttc 2866981 agcatacaca gggataaacg ccgccatatc gcgattcaat tgaaaagaat agccgttcag 2867041 ctgttttttc cctttttcga tctgaacggc atagatcgtt ttttctcctg tttttttatt 2867101 aacagttgta taaggagatg ttttttcagg aggcaatccg tttaacggct gaaaattttc 2867161 cggatcatcg taagcttgaa acatgtcttc aggcacgatg aaaacatctc cctcatgggc 2867221 ggtaatttca gtcagcagtt tttcctgaaa agctggaaag atatcgacct tcccggcatt 2867281 ctgctcggcg gcctttttta ttttttcctg tacgccagcc tgcatatcag aaaagagaat 2867341 gacatgcatt ccgtccggcc tgcttgagca tgatgccaaa aagagcactg agacgatcac 2867401 acacaaagcc gtacgtatcc tttttgtcat ttccccgctg acctaaaaag aggctccagc 2867461 tctgtcatag ctaaaataaa cgcgccggct ccgtgcagat cgtttgtgct tctttcgcgg 2867521 ctgacataat agtcatagaa accggctgac gttccgacac atatgtcttt gacgagaaac 2867581 gctccgtctt ctgatgtttc ggttttatgc tgaatcaagc cttgatacgc ttttagcagt 2867641 gttgtttcgt aagctctgtc tagatagcct ttattgattc cttttgcgat tgcgtacatg 2867701 tacagacagg atcctgagct ttccagccag ttatcagacc tgtctccctt atcaacgatc 2867761 tggtaccata accccgtctc tttgtcttga tagcgacaga tgcttttaat catgtcctgc 2867821 agcgtgtttt tccacacatg acggttcgga tgcttcttcg gcagctcttc aatcatgtca 2867881 gcaagagaca tgacgtacca gccgatggaa cgtgcccaaa attccggtga acagcctgtc 2867941 tcttcattgg cccaaggcat ttttttcgct tcatcccagg cgtgataaaa aagtccggtt 2868001 tttgcatcct tcgtatgctt tctcatcaat gactcctgaa gcacaacctg atcaaacagc 2868061 tccgtctcct gcttcagatt ggcatatttc agtgcaaacg gcccccccat gtataagccg 2868121 tcaagccaca tttggtaagg ataaccgtct ttgtgccaaa aaccgccctc agacgtccgg 2868181 ttcagtgttc catataagct gcgcagcctt tttgccgctt tgacataccg ttcatccttc 2868241 gtctgctcgt ataatggaaa aagaatgaga cctgcttgaa tggcgtccag ttcatctctt 2868301 ctaaataata gattgccatt atcatcgatt aagagatctg cataagcctt cgcatactca 2868361 aaataccgct tttccccggt tgcttcccac agccgcaata caccgcataa gaaaacaccc 2868421 tgatggtagt gccagcggtt tgcaggtggc agctcctcga ctgtgtacgt gttcataatg 2868481 gtgtttgcca atgcctccgc gtacgtaaga ggcgatttta cagcgattga ttgatccatt 2868541 gatcccatcc ctttcctaat aaattccttc ctcgccaaat ttcttcgcca aacgattcgc 2868601 tagcatgacc aaaatcagcc cgaccgccgc tttaaatacg ccgactgctg tactgtagct 2868661 gaattggccc tgtttcagcc ctgcagtata aacatacgta tcaaaaattt ccgccacttc 2868721 cctgttagtc gcatttaaca gcaaatacac atgctcgaag ccaagctcca gcgtgtctcc 2868781 gattttcaaa atcagcaaaa cgacgataac gcttttaatg gcgggcagcg taatatgcca 2868841 catttgccgc agccgtcccg ctccgtccat tttcgccgct tcatacagct gggggtcaac 2868901 cgctgtaatg gccgccagat aaatgatcgt cgaccagccc gcttccctcc agataacctg 2868961 cagaatatac aggggccgga accattcttc gttcagcaga aaattgattt tttcaccgcc 2869021 aaaaaacaca atcagttcat taatcaagcc tccgtctacc gttaaaagca caaacgaaag 2869081 cgatacaaca atgacccaag acataaaatg cgggatataa atcagcgtct gaacaaattt 2869141 tttaaagaga gcaatccgca cttcgttcaa tagaagcgcc agcagtatcg gcaccgggaa 2869201 aaatatggcc aggttcaaag caaataacac gagcgtgttt tttaacaaga gaaaaaatgt 2869261 aggctcagta aacagcctga taaaatgctt cagccccacc cactcactgc ccaaaatgcc 2869321 gaggaacggc tgataatcct gaaacgcaat cacaattccc cacatcggga catacttaaa 2869381 aagcaaaaaa taaatacacc ccggcaaaat catcaagtac aaatattttt gttgaatcag 2869441 cttgattagt aagcgctttc ttttttcttt tttaaaaatg actgcatcaa cagccggcgc 2869501 ttgcgcttct gctgttttca ttttttccta gcctcctttc acggattctt gcattcactg 2869561 tagcgcagca ggcaaaagtc cgtctacaat catatgatca catcctgttt tatcccttta 2869621 taatcaaggg ttcagccggt ccacctgaaa aaaagacacc gatattagaa aatgattatt 2869681 gacaatatct atcaatcttt ggattaattg tattaaggtg aagtggatgt tatgaaatgg 2869741 ggggttttat gaaaagaagc caatacaagt tttactacaa actgatcacg tttttctgcc 2869801 tgctcagcac cattccggtt attttggtcg gattattttc gtacgagcac tctcagaaaa 2869861 cggctatttc caacgtttcg gaggaaaaat tcgacacact ccagcagacc cagcaaagca 2869921 tcgagcatat attgaaaacc gtcgatcact ctttaaccca ctatgtgagt tcgccgcctc 2869981 tccttcgcac attgtccgag cctttgcact cagaccaatt tcaaatctat aaccaagtga 2870041 accaagagct caattatctg caaagctttg ataccgatct gtccaacatg acgttagtca 2870101 gttatacgaa aaaatggtac atgaacaatt ccggtttgta ccgtttgaat acagacactc 2870161 ttcatgaagc agcctcagcg tacacgaaac aaaaagcgag ccgctcctat tggacgcttg 2870221 aggaaaacaa tcatttgatt tcaaccaaag aaggcacagc agaaaactgc cgctacaata 2870281 tcaatttaat taagcagctt cctttgaaca gcacaaatac aaagggattg gccgccgcaa 2870341 gcatcccgag ctgttcgctt gtcaaaaata tgcccggcta ttcaaacgcc aacaacctgt 2870401 ttatcatcga tgaaaaaggc ctcatcatcc ttcataacaa tatgtctgac gttggtgaat 2870461 ctcttcataa cgacggcttt gtccaaaaag tgctggcgca aacggccaat agcggacagt 2870521 ttgaaacagt gattgaccgg attcattata aagtcaccta tcaaaaatct gactataatg 2870581 catggactta tttttctctc gtttccctgc ctgagttaaa aaaagaagcc aaatcaatcg 2870641 gctggatcac ttttgcagta tgcctcattt tgttaacgct ttcattgctg ttctcttggc 2870701 ttggctcccg ccatttttac aagccgatca gggtgcttta cgaatcattc gcaagacatg 2870761 gagccataca agagaaacaa cagcctcctc aaaatgaatt tgagttaatt gaacagagct 2870821 ttaagcagct gaaggacaga aatgacgacc ttgaagaaac gatgaagcag caggccactc 2870881 atctgcagca atattttatg gtcaggctta tgcttggaaa actgacggat gaggaggttg 2870941 ataaccgttt tgaaagcctc ggcttaaagc aaaattggcg gcaccttgcc ctgcttgtgc 2871001 tccaaattga cacactgaat catacgcctt atgagaaaaa agatatggat ctgcttttgt 2871061 ttgccgtcaa cagcctgatt gagcgcaaca tcccgacgga caaacatctt gcccccgccg 2871121 tagttgacaa acagcaggcg acgattttga tcaatcaaag cgggacaaag gaagaattca 2871181 tggctgagct gaatgagact gcaaggatga ttcaggaaaa agcggaagct gagctgcagc 2871241 tgtctgtcag catcggcatc agccagccgt ttgatgtgct gacaaaagcg aaaacagcct 2871301 atgcggaagg ctcagaagcg ttgaaatatc ggctgaaagc ggaaaacaag tcgatcatct 2871361 tttacgaaga ccttgaccag aaaaaaacct tcaaaaccca ttttccaaag cagcttcagc 2871421 atgagctgtt cgatgctgtc aaagcaggag acaaggagaa agcggataaa tgcctgcacg 2871481 cgattttaca agccattttc acccagaaca ccaacccgta tcaatttcaa atcgccatcg 2871541 cccgtttttt gaaccatgtg attgagctga tgcatgtgct tgggatcgaa ttgtttgagc 2871601 ttgaagaaaa caaaatgctg tatgaccaaa tttttgagct gaaaacgttc gaggataccg 2871661 aaaactggct aaagaatgag tttattgatc cgatgacaga caaagtgaac gcccgcgcgg 2871721 atgcccagta caaaaatatt tccgacaaca tcattcatat catccatcat gagtttgaat 2871781 ccgaattgac actggacgaa atcgcacgca ggctgcatta caacccaaat tatttaagca 2871841 gtattttcaa aaaagaaatg ggaatttcat tcagcgagta tgtctcaagc taccgacacc 2871901 atatggcgaa aagctggctt gccgaaaccg acatggcggt caaggacatt gccgaaaagc 2871961 tgaaatataa aaactcccaa aacttcatca gatcatttaa gaagctggaa gggattacac 2872021 cgggaaacta ccgccagcaa aaaagaagca tgtaaaaaac ccaaaaccgc ttgcgcgttt 2872081 tgggtttttc caatgttatt ttgcttgttt aaacgcttct tcgtattcct gaataatttg 2872141 ttttcctccg cttgactccc atttttccac ttctttatcg aactggcttt ctgtgatgtc 2872201 tccaatcata tatttgtagg tcgcgtcatc aatgattttc ttcagttcgt caccccgttc 2872261 cgactccgat gcggaataca ggctttcagc cgggtttgag acgataatct tttcattgtc 2872321 ctcggtcagc tcctcgtacg ccgtccgaag cggatctcca gtgtttttta agtaggcttt 2872381 atcaatggca attaaagcgg acagcggctg aatatcagtc tgccagtctt ttacctggct 2872441 ttctttgcgt gtaaacgttt tgtcctcacc tttgttgtaa tgaacgccgt caatgccata 2872501 agtcatcagg ctatagacat cttcttcggc aattcggtca aaaaacgcca agatccgttt 2872561 aagctcagct tccgttttca cactcgtttt cgggaaagca aacacgccgt tatggcctcc 2872621 tgatgcccat acccgctctt tcccatctgg gccttttatg cggttgatga tctcgagctt 2872681 catcgattta tcagaggcat ggtcgcgcag attgaccgca tctaccatat tgccaatata 2872741 aattccggct tttccttgag aaaacagctc ttgctgctgg gttttgcttg tgacgggaaa 2872801 atccttattc atatacccgt tatcacgcag ctttttcata tagttcatcg tgtctttgta 2872861 ttcctgtgtc atgaaatcag gcgtgaattt gccgcccgat tccttccaat ctgtcggcat 2872921 gccttcatac gagccaatcg ttttaaacgc gccgtaaatc aagtcattac ggtctgccag 2872981 cccgaatgta tcatctttcc catccttgtc cgggtcgtcc tccgtaaatg ctttggccac 2873041 ttcataaagc tcatccaacg ttttcggggt tttcaaattt aaattgtcca gccagtcctt 2873101 ccgaatgacg atcccctgtc tggaaagcgg gcgctctctg tatatcccgt agagcttgcc 2873161 gtcaattgtc acatttttat taatgagttt gttcattttg tttaagttgg gataatcctt 2873221 gatataatcg ccgatttccc aaaacattcc tgaccgaaag gcattcatga ctgacgaatt 2873281 tttaatatcc tggatggtca cgatttgcgg aagattgccg gctgcaagcg ctgcattcag 2873341 cctgtcttct ttcaccgcgt ctggaaccca ggtgatgtcg agttctgtat ttgtcagctt 2873401 ttcaatttct ttaatcgccc tgtctttcgg cggctgctgg tgatacaaaa tcgccatcca 2873461 agacagcttt acctttgaat ctgggccagc tttgccttca gccgaagact gatcagttcc 2873521 tttacagccc gccagcactc cgccgagtgc cagtacaagc acaatcaaaa gcaccctcca 2873581 tttgtttccc atcgtacccc tccgtttcat atttctttat cctttgacag atcccagcaa 2873641 agctcctttt gcaaaatgct tttgtataaa cggatagaca agcagaacag ggatggtcgc 2873701 caccactatg accgccattt taatggtttg ctcaggcggc gggctgcccg accccatttc 2873761 agacatatcc ccctgcatac cgcttgatac aatgacgatt tggcgcagaa gcacctgaat 2873821 tggccatttt gctgaatcat ttaagtacaa gatcgctgtc atatacgtgt tccaatacgt 2873881 gaccgcataa aatagtgaaa tcgttgcgat cgcaggaaga gacagcggca gcacaatttt 2873941 aaagaatatg cccagatcat tgcacccgtc aattttcgcg gactcttcca ggcttgacgg 2874001 gatattttga aagaagtttt tcagaatgat caggttaaag gcattaatgg ctgtcggcaa 2874061 aataagcgcc cagtaagaat cgagcaatcc aagcgatttg accacaagga aagtcggaat 2874121 catgccgccg ctaaacagca tcgtaaatac gacgagaaac atgagcggct gccggccgat 2874181 taaatcacgg cgggataacc cgtaagccat cagtgacgaa agaaacatgc tgaccgcagt 2874241 gcctatcact gtcacaaaca cagaaacaag caaactctta taaataatat ctgttgaaaa 2874301 aatgtagcga taagcatcta gcgaaaaagt ggtcggtatt aaaataaatt ttttcgacac 2874361 gacttcttct actgtggcaa aggatgctgc gataacatga atgaacggaa gtacgcatat 2874421 taaagcgaac atcagcaaga aaccataaat caacatatca aacagacggt ttttcagtga 2874481 atgtgcgata gctcccacct ccctttgtaa gcgttatcat atttttggaa accgagctca 2874541 gcatgtgacg atatcgtgtc taaaatgtag caaatctgtg attgccatgt ctataatcat 2874601 ttgaacagtg tccccggccg ggcgggggct gccgcgaatt gagaccgata acaaaagaaa 2874661 aagagcataa tcttagaaaa tgattatgct ccgttctcct cctcgttcag aagttcagcc 2874721 gtattgattt gtggcgaaaa cccaagttca ttcacggcag attcaatgga ccatggccgg 2874781 cccggattat cagagacggc gtaataagtg ccataccgga tgttggtctc aatggcggct 2874841 ttgaaaatcg acagcagatc ggggtgagaa agcagtgtct ttttcgtccg ttctttttca 2874901 tgcagcgtat ccatttcatc tgtcacgact gttccgattc gaaggttgat tactgatagc 2874961 ttattttcca aataaaacaa atggccgatc tgttcagagg tcagctttaa tacaccgtac 2875021 aagttttttg acagcggata atcgcttgtt gtgatttccc gtcctaagag cgagcgcccg 2875081 tctttttcat atacatctgt gacatgattg ctgctggcga acacgagctt ttgaatgccg 2875141 agctccgctg ccgcacggca cagataatag cttgccctat agaaaacatc cgtcattttt 2875201 tcaaactcag cgatgtccat aatatcgtat ttgattttca cagcgagtaa attcaagatg 2875261 gcatcggtat cttttggaat cttcttcaac agctcctcat aatttgccgc gtcagcctga 2875321 atggaagagg ctttgccatc gaaatgatct ttatcaagca cagtcacttc atagtctgaa 2875381 ataagccctt cagcaagcag tctcccaatc acaccatttc cgccggcgat cagcactttt 2875441 ttcacgatgt tcactcccct tttttataga ttgcccattt tcggcggggc tgacactttt 2875501 ttggcactca cattcttagg cttattcaaa agtcaccggc agctcctcaa gcgcccgaaa 2875561 tccaaaaagc ggccgatacc gccattcaaa atccgcaaga ttaaggctgg gcattcgctg 2875621 cagaagagtg ttaatcgcaa tttgcgcttc taatcgtgcc agcgaggacc ctaagcaaac 2875681 atgatggcca tgcccgaatg aaagatgcgg attaggactt ctcgtaatat cgaagacatc 2875741 ggggttcgtg aatatgctag ggtctcgatt agccgctcct aacaaaagat agacttgttc 2875801 tccttgacgg atcgtcaccc cgcagatgtc aatatcctct gacgcaactc tggctgtcat 2875861 ttgcgtgggg ctttcatagc gtaaacattc ctcgactgcg gtaccaataa gatctggatt 2875921 ttctctcagt ttcaaaagct gttctggatg ctgcagcaga caaaggactg aattgctgat 2875981 gagattgacc gttgtctcat gtccggcgat cgccagcaat atgcacgtag atgccgcctc 2876041 ctcttccgtc agcttatcct tttctctccc cttcaagagc atgctgatca tatcctgttg 2876101 agggtggcgt tttctctttt gaatcagctc tttgaaatat gccatagcct gcacagccat 2876161 aatattgccc tctgttaatg cctttcttga gcgggtaaaa tcaatcgttt gaatgagact 2876221 cgcagcccac tcctttaatt gctccctatc ttcctccggt acacctataa tgttagctat 2876281 gacaaaactt gctaaaggaa aagcaaagtc cgaaatgacc tccatctttt ttttaccttg 2876341 cacttgatca agcaaatgat ggacagtttc aatgatatac ggctgataac tctctgtcgt 2876401 tctcggcgta aacgctccgc tggcaagcgt ccgcaatcgt ctatgatcag gctggttctg 2876461 aaacagcatc atttgatttt gcacatgtga aaggtcctga tatttggttg agctctcagg 2876521 cagcggggtg cggactttga atctcgcatc tttcaaaata gcagccgttt cttcatatcc 2876581 tgtgacatac cagcccgggt attttaagaa actcccttta tagataggat gaacagctcg 2876641 caatgtgtcg taaaaagaat atgggttttt caaaaactca gaagatgcag ttgacgatgc 2876701 aattgtcacg tgattttctc ctttctgttc aaaaataaaa acaatcgaca tcataccgat 2876761 tgcttttatt gattctttca gcttttcgca cttaaactag ccttcatttc ttcgactgat 2876821 tcaacttcaa agcctaaatc actcagcatt ttatgatcct ccgtctcctc ttgcccggca 2876881 gttgttaagt agtctccgac aaaaatggag tttgcggcgt aaagccctaa tggctgcaat 2876941 gtgcggagat tgacctctct tcctccggaa atgcgaattt cttttgatgg attgataaaa 2877001 cggaacagcg ccagcacttt taaacaatac agcgggttta attcgttgac gccttctaac 2877061 ggcgtgccat caattgcatg caaaaaattc acaggaatgg aatccgcgtc aagagccttc 2877121 aagcttttgg cgatgtcaat gacatcctgt ttcgtctcct tcatcccgat aatggcgcct 2877181 gaacacggag acagccccga ttcttttgcg atttcaaccg tattgactct gtcatcgtat 2877241 gtatgtgagg ttgtgatgtt tgaatggttt ctctgtgacg tattcaaatt atgattatag 2877301 cggtctactc ctgcatcttt gagccgcttc gcctgctctg gcttcaacag tccaagacat 2877361 gcacaaatct tcagtccata cgtctcttta atttcctgaa ccgcatctac gacctgatcc 2877421 acttctctgt tagacggacc tctgccgctt gccacgatac aatatgtgcc gatattcaga 2877481 tcgtgcgccc gcttcgcgcc ttcaagcagc gtttccttat tcaccatccg gtaagactca 2877541 atcggcgctt tcgaaatcgc agactgtgaa caatagccgc agttttccgg gcagagcccg 2877601 gatttcgcat tcataatcat attgagcttt actttttttc cgtaaaagtg ttttctgatg 2877661 tgaaaagccc cgtgcattaa tagcaaaata tcttcatcag gacaatgtaa tattgaaagc 2877721 gcctcttcgt cagtcacttc tgctccagcc agcacccggt ctgcgagttc catccattga 2877781 ttcattctca tacccccact tgattcatca gtaatgatag attgatatgg tcttttacca 2877841 tatgtagaac cgtttctttc gtcacgttgg caagctttgg cgtaacccct aaaatcggca 2877901 caccgcataa gcgctcaatc atctcaggat tggttttttc atcttcatca ggagagtcac 2877961 tgattccatt gatgataatt ccggcgattg gaagccccat gctttctgca tatttgacag 2878021 ttaaaaaggt atgattaatg gttccaaggc gaggacgcgc cacaataatc atgggaagct 2878081 gcaacgcttt tatgacatga ctgaccaaat agtcctctcc caatggcaca gaaataccgc 2878141 ctgcaccttc tacgatgaag cattcatgtt tttctctaat ccgcccccaa tggcttaaaa 2878201 cctcttccat ggtgacagtc tttccctcaa gtttccctgc aacgtatggt gcaagcggcg 2878261 ccttgaaggc aaaaggcgta atgtcttcat gagaaagact ggtctgcgac atatctttca 2878321 gcaaacttgt atcactatct ggatgatggc gcgatatccc gcttaaaaat ggtttataca 2878381 ccccgacatg tctattattg tctttcaata aggcagcaag accgctggat ataaccgttt 2878441 tccctacttc tgtatcagtt cccgtcacaa aaaaacccct caaatgatgt gcagctcctt 2878501 tccgattgaa tgaaatgttt gcagcaaatg atcaatatca cccatactgt ggtcagacgt 2878561 gattgtaatt cgaatccggc tttcacccgg cgcaacggtt ggcggccgaa tggcaggagc 2878621 ataaattccc ttgccctgca gtttttcagc aaataggacc gttttatggg catcgccaat 2878681 gactacagga ataatcggtg tgtgatctcc tttcaccaca taacccatat tcttcagact 2878741 ggttctgatc atgctgatat aagaaaataa aagctgtcgt ttttccctgc tggcttcaat 2878801 gatgttgaaa gcctcgtgag cagccgcaca gctggctggc ggaatagcgg tttgaaagat 2878861 aaatgttctg gcatggttca gcaaaaagtc gatgaagacc gctgatcctg ccgcaaaacc 2878921 tccttccgcg ccaacagctt tgcttaaggt gccgataaca atgtcgggac aaacaccaaa 2878981 gtattcactc gttccttgtc ccgaatcgcc caaaactcct gttgcgtggg catcatcaac 2879041 gaccacgaag gcatgatagc gtttcgcaag tgagatgatc tgatcaagag gggcgattgt 2879101 gccatccatg ctgaatactc cgtctgttac gataaaacgg cgctgataac gctgtgtttc 2879161 attcagcttg ttttcaagat cattcatatc aatatgccga taaacaactg tatcagcctt 2879221 agaaagtcgg cagccgtcga tcatacttgc atgattgagc tggtcactta aaatgacatc 2879281 ttccttttct ggcaaggatg aaaggacacc gacattggcc aagtaaccgc tcgaaaacag 2879341 cagggccgct tctgtcagtt taaagctggc aatcttcttt tctagctttt catgccagac 2879401 cgaattgcct gtcgttaaac gtgaaccgct gcttcctgtc ccaaattgct gcaatgctgt 2879461 ttgggctgca tcgatcaaac gtctatcgct tgcgagccct aaataattgt ttgaggacca 2879521 gaccgtttga ttttcgccat caatattcct ctctggaacc ggcgctccat ccattgaccg 2879581 caggttacga tgtacgccgg cttctttcat tctgtctaac cgctcgttta accaggaatc 2879641 aatcttcaag gctcgtaacc tcgtggatcg cttgtttcat aatggcaacc atttccgaga 2879701 gctcttcagc tgtgctggca agaggaggaa gaaatgcaat cacgtcccca agcggtcttg 2879761 tcagcattcc taactctctc atttttaagg aaactttgta tccaatccgc cgatcagccg 2879821 ggtaaggttc tttagtttcc tttgatcgta caagctctgc accgcacata aagccaagct 2879881 gccgaatatc cccaacatga ggaagagcgt gcagatcttg aagaagaaaa tggagctttt 2879941 tacttttttc cgctacttgt tccacaatgt tttcagattc aaataatgcc agattttcaa 2880001 gcgcaaccgc acagccaagc tgattgcctg tataggaatg gccatggaaa aaggttttta 2880061 ggttttcata atcatcatag aatgccttat agatgtcttc agtggcaaac gtaacggcaa 2880121 ttggcaaata gcctcctgta atgcctttac cggcagccat cagatcaggc tggacattct 2880181 cgtgctcgca cgcaaacatt tttcctgtac ggccaaagcc tgtagcgact tcatcaacga 2880241 tcattaagac atcgtatgtt gtacatagct cgcgcacgcc tgccaaatat ccttccggca 2880301 tcacgatcat accggacgcg ccttgtacca ttgattcaat ggaaagcgcg gcaatttcct 2880361 catgatgttc ctcaagcagc tgtgcaagct ctcggaggca ctgatcacgg cactcatcag 2880421 gatcaccgct ttcagaacga tacacataag gaatcggggc cttgtaactc tcgaacatca 2880481 acgggccgta tacgtggtga aaaagctcaa ttgaaccgac actgacggcg ccaatcgtat 2880541 caccgtgata cccgtttttc attgcgatga atttttgttt ctcgggcttc ccgatgttct 2880601 tccaatactg aaacgccatt tttagggcta tttccatcgc ctctgcgccg ctgtctgaat 2880661 aaaagacccg cgtgagcttt tttgggctga tgtcgattaa tgtttcggca agctgggttg 2880721 ctggaacatt ggtcatgccc aataacgtgg agtgcgcaat ttttccgagc tgttttttta 2880781 tggcgtcatc tagttctttt ttgcggtgtc cgtggacatt aagccaaacc gatgaaaaac 2880841 cgtcatagta ttccttgccg tttatgtctt tgactttgat tccagtcccg ctttcgatga 2880901 ttaaggggtt ttcatcataa tctttcattt gggtaaatgg cagccagagg tgctttttac 2880961 ttttttctat caaatcatga gtcatgatct tcctcccact ctattaaaat aggctgcttc 2881021 tccaggtcat gtatgtacgt gtttacatca ttggatccat caataaaaaa gactcggcag 2881081 ccctcttcag tcccgtattc tttcattgct gtaatacgct gatagcccat tttcttaccc 2881141 gcaacatagc ctgttatgta atccggatcg tccgaccagc ataattctgc aacgactgcc 2881201 gggtgccggc ttacctttga agcgagcgca agggcctctt ttattcttga atgagctggc 2881261 acgtgactgt gaagcgccca tttttcaaaa ttagcgtccg gccaatccat tctggagacc 2881321 cgcacccctt tttcttttgt ttgatccatt cgcttgcctg tatgaatatc aaacaacacc 2881381 gcacccctga catctgacca ttcagggatt tgttcatatg ctttttcaat cacgtctcgt 2881441 gaaacgcctt ctttttccaa taacaatcgg gcaagctttt gtccttcttc cgggcagctc 2881501 acttcattcg tatgcacagg caatggctga atggttttta tcgattcatg tacctcttca 2881561 aattgaattt gcataaaatc aggttttcct cttgaatggg ataacccttt ttctaataaa 2881621 gcattgactg tatgcttcat ctcatggaaa ggaataagcc gttctccgcc ggatatatgc 2881681 tttccgccgt cttcatgaga tccattcatt gaagccctca ttctgacact ataaaaagtt 2881741 tcttcttgca tcatttctcg ccctttcact gataactgaa gaacgtgtag cgcttctcac 2881801 ctaaattgtt aaccaattat attcaaaggt taacaattag aatatattat tctctcctgt 2881861 ttctgtcaat agaagaaagg atcgatttat ggcagttggt taaaaggaaa caaaaagacc 2881921 gttttcacac aaaacggtct ttttcgattt ctttttacag tcacagccac ttttgcaaaa 2881981 accggacagc ttcatgcctt ataactgctg tttcgaaatg tcccgaagca gaacggacca 2882041 ctcggtagca atcagcagct ccctgtccag catagacagc tgtcaattct ttttcgattt 2882101 tgtccacgcc ctcagccggc gttaaccgat cgtgtacacc aacaagacta aggtgcgggc 2882161 gcggcgcgat caggctttgg atctccgatg cggaaaaatg ctttgcaagc gatgggacgt 2882221 aataataaaa gccgtgcctg tcaagattct gtgttttgat cagcacgtga tgatccacct 2882281 ggctgcacaa atccacacac accttaatcc ggtcatcgag cgccgctgtc caccacgcca 2882341 tcaaacctcc catagacatg ccgatggttc cgatcctgtc aggctgaaca tcagagcgtg 2882401 actgcatata gtctaacgca cttaaactgt cataaatcat catcccccac atcacttttc 2882461 cggtgagaag catttcttta aatatctcgc tttccgcttt tccccgccga tctccaaacc 2882521 cccaatgatc aatcgcaaga acgccgtatc cgagtgaagt aagctcatca gaaaaagaag 2882581 gcgttttcaa ataatccgct ccctcaatca gctcactttt tcccctatca tactggcctc 2882641 catgcgaatg ctgaaacaat acggctgggc acggtccttc tgttttcttc ggcttcacaa 2882701 aataagcggg cgccttttca tgtccattta aatcgagcag gagcgtttca acgatatttt 2882761 cttctctttc ttcaatacgt aatgtctcaa cactgattgg cctccgatca ggcaaatcac 2882821 caagcaatcg aaacagttgc tttcttcttt cggctctcat cccatcaccc ttccttattc 2882881 gcttacttca catttacgag acagatctgg gttccccttt atttttccaa cataaatcac 2882941 atcatttact aaatatttag taaatattat ggaatatttc gaaaacaatt attgtaaccg 2883001 cttactttta tatgataata tcaatttatc aaaaacagat gagttaatat tttactaaat 2883061 agatgagagg gatacccatg gttcgtatta aagatatcgc cttgaaagct aaagtttcca 2883121 gcgcaactgt gtccagaatt ttaaatgaag atgagtcgct ttctgttgcg ggcgaaacga 2883181 gacaaagagt catcaacatc gctgaagagc ttggttatca aaccgttgcc aaacgccgaa 2883241 aatcccgcgg gcaaaaacag cgggctcagc cgctgatcgg tgtgctgagc tgtctgtccc 2883301 ctgatcagga aaggcaggac ccttattttt cttccattcg gaaagggatt gaaaaggaat 2883361 gctttgaaca ggaaattttc attacaaatt cgattcatct cggctccttt caggaacata 2883421 tctttcggga attggatggt gtcattgtca tcggccgtgt tcatgatgaa gcggttaagc 2883481 atatcagcgg gaggctggag catgccgtat ttatcaatca ttcaccagat ccgcaagcat 2883541 acgattcgat tggcatcgat tttgaatcgg cttcacgcca ggcgattgat caccttttcg 2883601 acttaggcta caaacggtta ggctacattg gcggacaaga aaaagagcat acgctgaagg 2883661 acggccaaag cattcgcaga acgattgaag ataaacgcct gaccgctttt ttggagtcag 2883721 ccgcccccca gcctgagcat gtgctgatcg gagaatacag catgcgtgag ggctatcgcc 2883781 tgatgaagaa agcaatcgat caaggccatc tgccggaagc attctttatt gccagcgatt 2883841 ctatggcgat cggcgcatta aaagcgctgc aggaagccgg actgcaagtg ccgcgggata 2883901 ccgcaatcgt cagctttaac ggcattgagg aagctgaatt tgccagcacg cctttaacga 2883961 cggtgaaggt atacacagag gaaatgggcc ggacaggcgt aaaactgctg cttgaccgtc 2884021 tcaatggccg aacgcttcct caacatgtca ccctgcctac aacattaatc gtaagacaaa 2884081 gctgcggatg tacagcaaag gaggtgacat aagcaaagat tcatcacgat gataaggagg 2884141 aaaagatgaa acacactttt gttttatttc tctctcttat tctgcttgtt ctgcccgggt 2884201 gttcagcaga gaaaagctca gcagataccg caaaaaagac gttaaccatt tattctacaa 2884261 tgtcaaccga cagtgaaaga gatacgttca gaaaactagc ggcagcattc gaaaaggaac 2884321 acagtgacat tcatgtcagc cttcatttcc caggcaatga ctatgaaaat atgatgcgtg 2884381 tcagaatggc ggccaatgat ttgccagatc tattcgatac acatggctgg gggaaaatca 2884441 ggtacggaga atatacagcg gatctccggg atatgaaatg gactcaagat cttgatccca 2884501 atttaaacag catcctcaaa aataaaagcg gaaaggtgta tgcctatcca atcaatcagg 2884561 caaaagacgg tctggcgtat aatcgcaata ttttagaccg ttacggcatt gctccgccgg 2884621 aaaccatgga tgactttatc aaagcactga gaacgattaa agaaaagagc aagggaagca 2884681 ttgttccctt ctggtttgcc ggatatgaca aaagctcatt cgcccaatat tacgaccaat 2884741 tcgctacacc tcttctcatc acagaccctg cccataatga aaaaaaacag ctcatcaacg 2884801 gcacttttca atggagtaaa ttcacttatt tatcagaaat cctcaaacaa atgcagaaag 2884861 aaaaattgat caatatcgac gccgtcacgg caaaaaaatc acagctcatt gaattaatgg 2884921 cccaaaacaa aatcgccttt acaatgcaag gcggcacact cggccaagac gttgcccaga 2884981 tcaacccgaa cgtcaaggtc ggcattatcc cgacacctgc catccatccc ggtgatgacc 2885041 cgatatggat cggcggtgaa cgctacaccc ttgcagcatg gaaagattcg cctcaattaa 2885101 aagaggcaaa agattttatc gcatttatgg cccgcccggc caatgccaaa caaatggctg 2885161 aagccacatc gcttccttca gggctgacca atgtgaaagc tgatattttc tacgcaaacg 2885221 attatgagta ttatcaagat gtcaaagtcg agccttactt cgaccggtta tacttgccaa 2885281 acggaatgtg ggatgtcctg ggcacggttg ggcaggagct cgcggctgac attttggcgc 2885341 ctcaagacat ttcgcagaag ctgggaagag aatataaacg actccgggag caatccgaaa 2885401 cacagggagc tgaaaacaat gagtgagatc gcaagggacg ttcatgtgaa acaggttaag 2885461 ccaaaaaagc agtcctcact ttggtggatg tacattcctg ctttgctctc cgttctggtc 2885521 tttatgattt acccgtttgt gaaaggcaca ttgattacct ttacaaactg gaacggattt 2885581 tcacaagtct accaatgggt tggattcgcg caatatgaaa ggctgttttc tgatcctgat 2885641 acttggcata tcttaaaaaa cacgctgcat tacgggcttg gcagcacctt ttttcaaaat 2885701 gtggtcgggc ttctgtacgc tctcctctta aatcaaagca ttaaaacgaa agcggtaaca 2885761 agaacaattg tgtatttgcc ggtgatgatc agcccgctca ttatgggcta catttggtac 2885821 tttttcttct cctatgacgg aggcgcgctc aacgatttgc tcggggtctt cggcatcagc 2885881 cctattaatg cgctcgccag tccctcgctc aatccatgga tcattgtcat gattaacacc 2885941 tatcaatatg tcgggatcgc tatggttgtc tacttagccg gtctgcaaag cattccgaaa 2886001 gactactatg aagcggcgca aatggatggc gcgaaacaag gccagcagtt ttttaccatc 2886061 acgctgccgc tgttaatgcc ctccattacc attaatatag tcatcaacat tatcggaggc 2886121 ttaaagctgt ttgacgtcat cattgcactc accgcaggcg gccccggaaa tgcgtcacaa 2886181 tccatgtcca cgtttatgta tgatttgtat ttcaaacggc aggatgccgg ctatgccgca 2886241 acgcaaggca tatttatggc atttgtcatt ttgatcatca gcttttgcgc gcttgcgtac 2886301 tttaaaagaa aggagacgga aatgtcatga gagccgcccg tacaaaaagc atgcggatca 2886361 ttacgcttct tgcagccatt gtggcctgtg cgcattttat tcctttttat atcctgctga 2886421 ccacttcatt gaaagcaaaa ggagactaca gttcgaaatg gatatttcca gccgacatct 2886481 cctttcataa tttttcagag gcgtgggagc gcgcttcgct aggaaactct tttataaaca 2886541 ccatgatcat cacaggtttt tctgccttgt tattaattat attcggctca cttgccgcct 2886601 acccgcttgc ccggcgggaa acgaaactga ataaagccgt ttttgccttg ctgatttcca 2886661 ttatgatcat ccctccgtta acgtccatgg ttcctttgta ccgaatggtc gtggacgccg 2886721 gaatggtcaa tacacacgca atcgccattt tcatcaatac agcggcttac atgccgttaa 2886781 ccgtattctt atattcaggc tttatccgat cgaccattcc aaaagagctt gtagaagccg 2886841 caagaattga cggtgcaggc atgctgaaaa tcttttttac gattgtgttt cctctgctga 2886901 agccgatcac tgcgaccatc tgtatcattt cttgtgtctt tatttggaac gactatcaat 2886961 ttgccatttt ctttttacaa gatcaaaagg ttcagacatt aacagtagcc atggcaggtt 2887021 ttttcggaga aaacgcaaac aaccttcatt tagttgccgc agcggcactt atggcaatgc 2887081 tgccgatggt tgttctgttt ttggcgctgc aaaaatactt tattgccggc ctgtcttccg 2887141 gagcggtaaa gggttaacat taaaggggga agcaatatga aaaagattac atttatcggt 2887201 gcagggagca cgattttcgc caaaaatgtt ttgggagact gcctgttaac agaggcactg 2887261 aatggatttg agttcgctct ttacgacatt gatcccaaac gcctgcagga atcccagctc 2887321 atgctcgaaa atctaagaga ccgttataac ccaagtgtgg ccatcaacag ctatgatgac 2887381 agaaaactcg ccttgcaaaa cgcaggctat gtcatcaatg cgattcaggt tggaggatac 2887441 aaaccgagca cagtcatcga tttcgagatt cctaaacggt atgggctgcg ccagacgatc 2887501 gccgatacag taggcatcgg cgggatattc agatctctca gaacaatccc ggtcttattt 2887561 gatatcgcaa aagatatgga ggaaatgtgc cctgacgcat ggttcttaaa ctatacaaat 2887621 ccaatggcca ctcttacagg cgccatgctc cgctatacca atatcaaaac aatcgggctc 2887681 tgccacagtg ttcaagtgtg cacgaaggat ttatttaaag ctctcggaat ggagcatgac 2887741 ggaattgagg aacgcattgc gggcattaat catatggctt ggcttttgga agtcaaaaaa 2887801 gacggcacag atttatatcc agaaatcaaa aggagagcga aagaaaaaca aaaaacaaag 2887861 catcatgata tggtgcggtt tgaattaatg gataagttcg gctattatgt cacggaatcg 2887921 tccgaacata acgcagagta tcacccgtac tttattaaac ggaattaccc tgaactgatc 2887981 agcgagctgc aaatcccgct cgacgaatat ccgagaaggt gcgtcaagca gattgaaaat 2888041 tgggagaaaa tgcgggatga tatcgtcaat aataaaaacc ttacgcacga acgctcaaag 2888101 gaatatggtt caagaattat agaagcaatg gaaacaaacg aaccattcac cttcggagga 2888161 aacgtcttga atacagggct gatcaccaac cttccttcaa aagcggttgt ggaagtgaca 2888221 tgcgtcgccg acagaaaaaa aattacaccg tgcttcgccg gagaactgcc tgagcagctt 2888281 gcagccttaa accggacgaa tattaataca cagctgatga caatcgaagc ggctgtcaca 2888341 cgaaaaaaag aagcggttta ccaagctgca atgcttgatc cgcatacaag cgcggagctt 2888401 tccatgaagg acatcatctc catgtgcgac gatttatttg cagcacacgg cgattggctt 2888461 ccggaataca aataaaaact aggggaccgc tctcccctag ttttttggtt ttgtttcgcc 2888521 ttcccaggcc atcatgccgc cttcaacatt gactgtttta aagccttgct catccaggta 2888581 cttgcagacg ttcatgctgc gcattcctga gcggcagata aatacgtact ctttgtcttt 2888641 atcaagggtt tccatttttt caggaatatc ccccatgcga atatgaacgg cttgcgggat 2888701 catgccttcc gctacctctt catcttctct gacatcaatt aaatataatt cttcgtccgc 2888761 ctcaattttt tctttcaaag cggctgtgct gatttctttt atttccaaag aaaacactcc 2888821 tattcacagt gatcatgttc agtatatcaa agtcagccga acgattgcta ttctgagact 2888881 gatgaaaaaa aatccccttt tggcaaaggg gattttttct aggcttagtt tgccacaata 2888941 ttgacaagct tcccaggcac cgcgatgatt ttccgaatcg ttttgccttc aagctgctct 2889001 ttgacctttt catctgcttg agcaagctgt tccagctgtt ctttcgttgc atcggcagga 2889061 acctgtaatt tcgcttttac ttttccgttc agctgaacaa cgatttcaac ttcatcatcc 2889121 acaagttttg tttcatcata tacaggccaa gcttcgtagg caattgtgcc ggaatggcca 2889181 agcttctccc atagctcttc cgctaagtgt ggcgcgacag gagaaagaag cttcacgaag 2889241 ccttccatat attctttcgg cagttctgtt gctttataag cttcattaat aaagaccatc 2889301 agctgggaaa tacccgtgtt gaaacgaagg ccttcataat ggtctgtgac tttcatgacc 2889361 gtttcatgat agacgcgctc caatgtttca cccgcgcctt caacgatttt tccattaagc 2889421 tcaccgctgt cttcaataaa taggcgccat acacggtcaa ggaaacggcg cgcaccgtct 2889481 aatcctgatt cagaccaggc gattgaagca tcaagaggtc ccatgaacat ttcgtacaat 2889541 ctcagcgtat cagcaccgtg agaggccacg atttcgtcag gattgacaac gttcccttta 2889601 gatttactca ttttttcgtt gttttcgccg agaatcattc cttggttgta cagcttttgg 2889661 aacggttctt tcgtcggcac tacgccgata tcataaagga acttatgcca gaagcgggca 2889721 tacagaaggt gaagcacggc atgttctgca ccgccgatat acatatcgac cggaagccat 2889781 ttttccaatt tttctggtga tgccagctga tccggattgt gcggatcaat atagcgcaag 2889841 aaataccagc agcttcccgc ccattgcggc attgtattcg tttctcttct tccttttttc 2889901 cctgtctcag ggtctgtgac ttccacccac tctttaatgt tcgcaagcgg tgattcgccc 2889961 gttccgctcg gtttgatttc atccgttttt ggcaaaatca gcggcagctc ctcttccggg 2890021 acagctgttg acgttccgtc ttcccaatga atgaccggaa tcggctcgcc ccaataacgc 2890081 tggcggctga agagccagtc acgaagacgg tacgtcactt tcttctcacc gtttttcgtt 2890141 tcttccagcc aagcgatcac tttttcaatc gcttcctgtt tgtgaaggcc gttcaggaaa 2890201 tcagagttca cgtgctcgcc gtcgccagta taggctgctt cctcaacgtt cccgcctttt 2890261 acgacttcct tcaccggaag gccgaatgtt ttggcgaatt caaaatcacg ctcatcgtgt 2890321 cctggaactg ccatgacagc acctgttccg tatgatgcaa gaacataatc cgcaatccaa 2890381 atcggcagtt tttctccgtt tacaggattg atcgcatacg ctcctgtaaa tacgcctgtc 2890441 tttgttttcg caagatctgt gcgttctagg tcactctttg attgaatttc tttgatataa 2890501 gcttcaacag cttctttttg ctctgccgtt gtgatgtttt ccaccaatgc gtgttccggg 2890561 gcaaggacag tgtatgtagc gccaaacagc gtatctggtc ttgttgtaaa cactgtaaag 2890621 gaatcatcat gtccatctat agcaaaatga acgtgagcgc cttccgaacg gccgatccag 2890681 ttgcgctgca tatctttaat gctttccggc caatcaagct cttccaagtc ctcaaggagc 2890741 ctgtccgcat aagcggtgat tttcagcatc cactgcttca ttgggcgtct ctctaccgga 2890801 tggccgccgc gttcgctctt gccgtcaatg acttcttcgt tggcaagaac agtaccgagc 2890861 gcagggcacc agtttacagg cacttcgtca acgtaagcaa ggcctttttc gtatagcttt 2890921 aagaaaatcc attgcgtcca tttatagtat tcagggtcag tcgtattgat ttcgcgatcc 2890981 cagtcatatg agaagccaag cgcttgaatt tggcggcgga agttatcaat attctgcttc 2891041 gtaaacacag cggggtcgtt ccctgtgtca agcgcgtact gttcagctgg caggccgaat 2891101 gcgtcccagc ccattggatg aaggacatca tagccctgca tgcgcttcat gcgggacaga 2891161 atatccgtag ctgtgtatcc ttcaggatgg ccgacgtgca acccagctcc agacggataa 2891221 ggaaacatgt ccagcgcgta aaatttttgt ttttcattat tatcaagagt ggcaaatgtt 2891281 ttgttttcaa gccaatatgt ctgccatttc ttttctatct ctttgtgctg aaaactcaaa 2891341 gtaaaaacct ccttctgatt gaatacggcg tgtatggttc aagtattgac gggaaggaga 2891401 ggattatatt cagaatattc ccaaactaaa aaaaactccc tcatcccaaa aagggacgag 2891461 agactttcgt tttcccgcgg taccaccctc gttagcgcgg catacgccgc actcacttga 2891521 tacttttaac gcagttatgc gtcagcggct tttcaccgct gcaactctga ggtgagttcg 2891581 gaaacaaact tgattgactt tcaccagccg tcaactctct gcaacaatat ctgtttctta 2891641 ctgctcctct tcattgttct tatcgcaacc gtaatctaac tgtattttat agaattctgt 2891701 tcataagtgc aagcaggttt gtatacaatg ggaatgtacc ctgaacgggc ggagattgag 2891761 gacaattatt cgggtggagt tttggtttga cgtttggact cggccggttc gccgccgctg 2891821 ttcagttctc tcacaaagtc aaaacttctg agaacagctt caccgccgta gcctgagata 2891881 atggataaga tgacaagttg aattcctgaa tcggggtcag cggataatac aagtaaaatg 2891941 gaagccgtca tgccgataaa ccaatcttcc aaaaatccaa ggtagataaa ccgcttcgtc 2892001 attctgggct tctccagcct gcctctcttt ttcacatgac cgagaatccc catgattcct 2892061 ccaattacac aagcaatgag tacctgatgc agcatcttca tcatcacctt cctaaagccc 2892121 ttatttcgta aagcgacttc aggccatcca gcccccttaa acgattccga tgattttcga 2892181 tatctacata ccggcaaatc tgtaaaaagc ttgtttcttc cattatatgt gaacacatga 2892241 tcggtaagct tgatgcattg gattcatttt tcacccagtg acattgacct agtcacctat 2892301 ttagcatgta gaaaaccttt ccgttcatat gttcaaattc tgttcttatt tttagtgtat 2892361 acgaggacaa gccctaatga caaacaacaa actgcacttg cttgaatcag aacatgtgtt 2892421 gtgctacggt tactgtagaa ttcattttta aaaaggggaa tatcaggctt tcgcatagca 2892481 agctgacggc ctaaggggga tttatatggc tagttttcaa tcatttggga taccaggaca 2892541 gctggaagtc atcaaaaaag cacttgatca cgtgcgagtc ggtgtggtaa ttacagatcc 2892601 cgcacttgaa gataatccta ttgtctacgt aaatcaaggc tttgttcaaa tgaccggcta 2892661 cgagaccgag gaaattttag gaaagaactg tcgcttctta caggggaaac acacagatcc 2892721 tgcagaagtg gacaacatca gaaccgcttt acaaaataaa gaaccggtca ccgttcagat 2892781 ccaaaactac aaaaaagacg gaacgatgtt ctggaatgaa ttaaatattg atccaatgga 2892841 aatagaggat aaaacgtatt ttgtcggaat tcagaatgat atcaccaagc aaaaagaata 2892901 tgaaaagctt ctcgaggatt ccctcacgga aattactgca ctttcaactc ctattgtccc 2892961 gattcgcaat ggcatttcgg ctcttccgct agtcggaaac ctgacagagg agcgatttaa 2893021 ttccatcgtt tgcacattga cgaatatctt atcaacatcc aaagatgatt atttgatcat 2893081 tgatttatcc ggattggccc aagtgaacga acaaacggcc gaccaaattt tcaagctgag 2893141 ccatttgctg aaattgaccg gaactgagtt aatcattact ggcattaagc ctgaattggc 2893201 tatgaaaatg aataaactgg atgccaattt ttcgtcgctg aaaacatatt caaatgtaaa 2893261 ggatgccgtt aaagtgcttc cgattatgta aaaagatccc gctcacccag ctggatcttt 2893321 cagattgttg acaaaatcct aaaatggttt tcattttagg attttgtcat cttttcagcg 2893381 tgattgaaaa cccttgaagt ctaggaagga cgagcatagg agcggagcga atgttctaat 2893441 tcgtgagcac cgaagcgcag gcctgacaac gaatgcgagg gtttgtcgac acgctgaaag 2893501 atcccgctca ttcggcggga tcttttatta tgaagagatt gatgcctgct tatttgtttc 2893561 tttagctgat tttatccgtt tgtcatatag aagcgttgtg gcaatactga tcagcagcaa 2893621 taccaacaga gataaaacaa gagccctaat gccgtaatga tcgacaagca ctcctccgaa 2893681 caggggacca atcattctgc cgcctgtcgc cgcactgttg acaaagcctt gataaaagcc 2893741 ttctttccct ttaggggcaa gctgattggc aatagtcggc acagcaggcc aaacaagcat 2893801 ttctccgata gtcaggatca ccatcgcagc gagaaacatc ggaaattgct ttgcagtcag 2893861 cagcatgctg aaagacacaa taaaaatgat aaagccgatg accatttgcg cttttagcga 2893921 ctcggcccat tttttcacca caaaactgac gagcggctgg ccgagcacaa tgagaattcc 2893981 gttaaccgtc cacagcacgc tgtataagga aagagatatt ccaatgcttt gtgtgtacga 2894041 agcaattgtg gttgaccact gagaataagc cagccatccg agtacatagc ctccgcttaa 2894101 aatgatcagt gcggcaaatt ttgctttgct gttcacagca tcataatcaa gcacggatgt 2894161 ttgggatgca tcgcccgttt gaatatttcg aaatccgaaa tatacaataa agaaaaagat 2894221 cagatacaat acggcatttg ccaaaaatac atatgaaaac gagaaagatg ccacgacacc 2894281 gccaagcgct gaaccaacgg ccacgcccgc gttttgcgcg acatatatcg cattaaatgc 2894341 cttccttccc ccttcaggcc ataccgatcc cgccattgcg tagcttgccg gaaaaacaac 2894401 accggagcca aagcccacaa tcgtcagcag cacaatatag gctggccaat catgaaaaaa 2894461 gacaagaccc atcaggcttg ctaacgtaat ggctatccca agcataatcg atttaaaacc 2894521 gccgatttta tcaaacaaaa aacctccgca taaattgcca gccacactgg cgccggaatt 2894581 cagcatcagg acaagtccgg ctactgttaa cgactttcct aaatgattat ggatataaat 2894641 cgtattcagc ggccataaaa aagaagcacc cgtcacattg ataaacattc caatgactaa 2894701 aattttaaga gcacgcggca tactcatccc cctttcttac ctaaaaaagc tcatgaaaaa 2894761 aacgaaacct aaaacggctc cgtacgaatc cagttatcat agcacattca ttctatctgt 2894821 ctctctcaca tttttcaact gatgagcgtg aaaaaatcta acaaatattg tttgaaaaat 2894881 gtaaaataaa tagaaaaagg ggtcatatta tggaaatggt attagcattc ttaggttttc 2894941 tggcatgtct cattgcactg ggctatggat tatatcacct tgtcagatat gtactgaaaa 2895001 aggaaaaacg tttctcaaag agactttttt ggccgctttt cattggaggc cttgtgctgc 2895061 tctttaccgg ggcagcattg gcagaacctg acactgccgc agcaaatgcc gagaaaaaat 2895121 attcagcgct aaacgccgaa tataaaaacc tcacaaaaga gcacgaagaa cttgagaaag 2895181 aatataaatc tgtcagctct gaagcaaaga aattaaaaga caacaaagaa gatcaagaca 2895241 agcttgagaa gcttaaaaac gaaaatagcg atctaaaaaa gactcagaaa tcattaaaag 2895301 ctgagattaa agagcttcaa gaaaatcaaa agcagctcaa agaagatgca aaaacggcaa 2895361 aggctgaaaa tgaaacactt cgacaagata aaacaaagct tgaaaatcaa ttaaaagaga 2895421 cggaaagcca aaccgccagc tctcatgaag acactggaag ttcttcaaac aatacgagta 2895481 aaagtgatga aaccaaaaca gctgacaaag cagaaggctg taatatcaaa ggaagcagaa 2895541 acggcatcta ccacacgcca ggcagtacat actacgaccg gacaaccgat ccggctgaaa 2895601 tgttttgctc agttgaagaa gctgaagccg ccggttatcg ggcgccaaaa cgataaacaa 2895661 aaagctccag aatgtctgga gctttttctg tttcacaacg acgatttaat gaccttctta 2895721 taataaagaa ctgacagaaa accaaaaatg gagtagagcg cagtatataa caccatcacc 2895781 ataatcatag gcgcccatac ctctgatccg aataagaacc agccggattg gacggcaaag 2895841 taactgtgga agaggccgac aacgagcgga atgccgaagt tgtacatttg tttgatgcgt 2895901 atccccttta tcaggtcgcc ctgcgtaaag ccgagttttc ttaaaattgt atagctcggt 2895961 ttttcatctt cactttcacc catttgttta aaataaagga tacaacctga tgtaatcagg 2896021 aacgttaacc ctaagaagcc gacgatgaac atcaccatac caaacagtga tttttgcgca 2896081 gcgcttgtat ctagtcttga taaatgctcg tttttcttgt tcacctgttg aaaaagctca 2896141 tttgcttttt ccatttgatc gtcatgtttc acattgacgc cgataaatgt agattgcgcc 2896201 agctgaatgc gggggtcttt atccttgtcc agctgtttaa acaggctgtc atccacaatg 2896261 acagcgggca tgcccccgct tgtaaacgtg taggacacaa gaaactcttc tcttaatcct 2896321 ttatatttta atggctgcgt ctcgtgcttg ctttttactt taataacacc agagtccttg 2896381 aaaaccatta ttttttgcag caagtcggtg tatcctgaga aaacggcttc tccagccgcc 2896441 acatcgactc cttttacatc tttgtcgcta acaacagcaa gctgcatatt gccgggatcg 2896501 ccctgcatct ctttcggagt tccatccata atatttgcaa tgtcaacatt tgcttgcagg 2896561 acaggtgttg ccttttttac aaacgagatg ttgctttccc tcaatttgtt ttcaaataac 2896621 ttggcatctt tctcattcat gaatgaaaaa tcagccgcta cattttgttc agcggtcttt 2896681 tccgacgagt aatacgagat gtaagcaaga gataacagcc cgatggcgag cgctgaaacg 2896741 gttgtaataa tcgtcagcag cagcgcattc gatttcattc tgaacatgat cgaagacagt 2896801 gacagaacct cagaaatatt taagtagccg cccttgcttt ttcgaatgat attcgagata 2896861 aacgtaactg atcctttata aaacaaaaac gtcccgataa tgacgctccc cagaatgaag 2896921 ctcatcgcaa caaacagttc attaatggtc ttaaattttc cgccaaacag ctcagaagac 2896981 acatagtatc ctgtcaaaat caacacgatg cctaaagcgc cgatcagcat ttggaaaaat 2897041 gatattttct tcactttgtc ttcagtggag gacgttactt taaacaaaga taaaatactc 2897101 tgttttttga taaacgtata attcatgatc atgatcaaaa ggtaaatgcc gcagaacaca 2897161 atgaccgttt ggaccaaggc ctgctcagaa aaatgcagtt tcgcatccgc tttgacatcg 2897221 acaattttga acagaatcat caagacaagc ttcgatatcg aaaacccggc cgctaccccg 2897281 atcgctaatg aaccgaaata cagcatgaca ttttctgcac ttaagatgcg aaaaatttta 2897341 tgcttcgtca ttccaattaa ttgaaacagc ccgatttctt tactccgtct cttaataaaa 2897401 atcgtattgg catataaaat gaagatcgcc actacagcca caagcaaaat cgaagcggtt 2897461 ttaatagccg cggctccctt gattgaagcc ttcacttcgt taattgctgg atcatactgc 2897521 agcgtgacaa aggcgaaata aagcgccacg ctaaagatga gcgcaaacac atacaaatag 2897581 taattccgga gattcttttt caaatttcgc aggatgagct gattaatgtt catgctgcac 2897641 cccgcctaac acgccttgcg ttttcataat atcctggaaa aacgtttgcc tgtcctggcc 2897701 ccctttattc agctgtgtat acatttgccc gtccttaata aaaatgactc tgccgcagta 2897761 gctggcagcg acgggatcat gggtaaccat aataatcgtc gcgttgcgtt tttgattgag 2897821 ctggctcagc ttatttaata gatcggaggc cgatttcgaa tcgagcgcgc cggtcggttc 2897881 atcagcgaaa ataatgctcg ggtcatgaat aaacgctctt ccagcggatg ttctctgctt 2897941 ctggccgccg gaaatttcat tcgggtattt atcccgcaat tcatatattc ccagttcctt 2898001 ggcaacttcc tcaaacttgc gattggcttc cttttttgat agtttcgtga tcgataaagg 2898061 cagaaggata ttctctttca ctgtcaatgt gtctaacaaa ttgtaatcct gaaagataaa 2898121 gcctaaatgc tgttttctaa attcagccag ctgcttttcc ttcatagccg tcatgtcatt 2898181 tccattaata tgaatggttc cgtgactgac ctgatcgatt gaggacagaa cgttgagcaa 2898241 agtggttttt cccgacccgg aagcacccat aatactgacg aattcgccct tttcaatgtg 2898301 aatatcgatg cccttcagca cttcctgttt attcagcttg tttccataac tttttcgaat 2898361 tttattcgct tctaaaatca ccatttacgc agtctccttt atattggata atctcattat 2898421 aaaaaggaat gccgggcttt tccttcgata cggcgaacaa aaaagaaaag catgtgacat 2898481 tttcgtcaca cgcttatgac atgttcaaat tgattccgta ttggaaaggt taatgtaaaa 2898541 actgttcccg caccaaactc cgactcaaca tcaatatgga tcaataacgg cgccgctgct 2898601 ttttttgcca agtacagccc catgccagtt gacgcttgat catggtgatc cgttgtggat 2898661 gtaaaccctt tatcaaaaat acgcggtaca tcttttggat caatgcccct gccacaatct 2898721 ttcacttgga gctgcgtctg ttcccctttt tgaaagcttt tgatctcgat ttcagaggct 2898781 tcgctgtatt tcaccgcgtt tgtcagcagc tgcctgatga taaacgccag ccattttgca 2898841 tcgctcagca cttctttggc ctcgagctgt atgtcaaaac cgatcccttt ttggatacac 2898901 cacgattgta aatctttgat ttctttaaag atcaaaggct gaagctgaat gaattctact 2898961 gacaggtcgt tttcaataaa tgaaatgcgt ttttgatgaa gctgctgatc aagaagcagg 2899021 tgaatacgca gccattcata tgacagctgg gatttcagtg ctttttcttc cattctatca 2899081 atgattaaat gcatcgctgt taatggagtt ttgacctcat ggatccatgc catcagctca 2899141 tctttttcat tttccaatgc taagcgatgc cgtgctgcgg tctgcttcaa gtgttctgtt 2899201 tgcccggcaa tgcttctttc aaccattgct tcaaacggcg tttccggttc atttatggct 2899261 gtcacatcga gattgttctc ccatgttttc aagcttttat aaaacgctgt ttctttccga 2899321 tagcggaacc aaaggaatat gataaaaaac aagatgcaca aatacaccat ataaagtaca 2899381 ttcccaaatg atatggaagg atcgacaaaa gcaatgaaca gcatcaaagc ctgctgaaac 2899441 aaaaacgcgg caatccagct ccgcctttcg ataaggaatg ctttaatcat agaacttgtc 2899501 ctcttccttc gcgatgtagc cctggcccac ctttgtctcg atatatgcac caagctgcag 2899561 ggcgtccagt ttttttcgca ggcgattgac attgacggtc agcgtattat cactaacaaa 2899621 acgctcatcg ttccacaagc ttctgatcag ctcttcccgg ctgacgatct tgtttttttg 2899681 ctctattaat tgttttagaa tgaacatttc atttttggtc agttcaacag atcctttgtc 2899741 attgctgacg aggttctgct ccgcgtctac agcagcgccg caccacgttt taatcgtact 2899801 cggctccgta ttataatggt gcacacgccg gaacatcgct tggattttcg cgatcagcac 2899861 atcaaaatga aatggctttt gaataaagtc atctgccccg agctgcatgg acatcaccat 2899921 atcagcagga tgatcccggg aggataaaaa gagaatcgga acatttgacc gggagcggat 2899981 cagacggcac caatgaaagc cgtcaaattt aggcagctgc acatcaataa tgacacaatc 2900041 aggattaacc gccgcaaatt cctgcagcac ctgactgaaa tcctgaatgc cgtatacatc 2900101 ataggaccat cccgttaaac gatccttgat ttcatgaaac agcgattcat catcttcaat 2900161 cagcaaaagt ttaaacaatc gactcaccgc actttttcct tttttatcaa gtgtatagca 2900221 aaacgccagc atgcgctata gaaaaagccg gctgtctcag ccggctcgtt cgcattataa 2900281 ttctcttctc aacgctgtca gcacgttggt tttggtagct tttctcgccg ggttcattcc 2900341 ggaaatgact gcgacccctc cgcaaatcac aacggcaatg atcacaaggc tcgccgggat 2900401 gtaggagaat gtgtaattca aatcgcccgc atcgccaccg cttgtggccg caagaatcat 2900461 cggaacggcc aggttgacaa ggtagctcac gccgtaagaa atgataatcc caatcacaca 2900521 gcctaaaatt ccgatatacg cgctttccat caagaacatt cggcgaatga ttgacgggct 2900581 cgccccaatc gctttcataa tgccgatctc ttgcgttctc tctgtcaccg ccatcgtcat 2900641 cgtgttaaaa atgccgatcg ctgaaatgat aactgcgata catccgacaa agatcagtcc 2900701 gattttgaag accatgaaga aggtattggc tccctcaagt tcagtagtca ctgatgtgac 2900761 atagtacccg tcatctgtta gatcatttgt cagctgttcc acattctcaa acttatcagc 2900821 aaaaacacca atgttcgttt caacatttcc gcctttgaaa tctaagaatt ccgaaaaatc 2900881 ttttttgaat tgatcactga taaaaatatt tgagtcctcc atccagtctt gagatggttt 2900941 ttttgtaata ccgacaattt taaagtcata tgtttttgtt tttgtaacat cccctgtttt 2901001 agaatctgtc ttcgatacac ttagttcaat tgttttattt agaatatctt tcgtatagcc 2901061 ctttggttct tttatatctt ctggatttcc ttttgcttcc tcgatttttt tgttatattc 2901121 ttccgattct tttttcgtta ataatctctt tgcgaagtcg tatcctacta cgatttcatt 2901181 ttccgacttt gcgactcttc ccttttccaa ttccatattg gcctttaatt catcattcat 2901241 attagtaaaa atgagatttg agctttcatt tgtacgattg cctaaagtag ctttgtttgg 2901301 ttcatacact tgcgttcttt ctacaactga ccttacgtga tcatacttct ctaaatcagc 2901361 ttttttaatc ggcttgtctc cttccttgcc cattacgctg actttcgtta caatctgctg 2901421 gctcattgtc atatctgtaa tcgtcttttg aatcccaaat ccaacggacg acaacacaac 2901481 caaaaacgca cacgccattg ttgtcgccag aatcgtcata aagacgcgaa gcctgttttt 2901541 cttcatattt cttctgataa aatgaacctg atccttaaac ctcaacggta attcctcctt 2901601 ttagcacacc atcatgaagc tgaaattttg aatgtccgat agaagcgact tcatcatcgt 2901661 gagtaatgat cacaaatgta atgccacgct cacgattcag ctgctggatc aattccagca 2901721 cttcatgttc cgtttctgaa tcaaggcttc ccgtcggctc atccgctaag ataatcgaag 2901781 gatttaaaat caatgctcga gcaatactga cacgctgctg ctggccgcct gacagttcat 2901841 tcggataatg agcggcgtgg ttttccagac cgacgcgttt cagcatgtcc tgcacctttt 2901901 gcttccgctc agatggcttg attcctttta acgccagcgg catttccaca ttctcatacg 2901961 tcgttaaacc cgggatgagc tgaaagctct gaaaaataaa cccgaaatgg tcaagccgaa 2902021 attgcgccca ttccttttca ttaaaccccg taacatcagt gccattaatg acaatccgcc 2902081 cttttgtcgg cgatatgtag ccggaaatta aattcaaaag cgttgatttc cctgagccgc 2902141 ttcgtccgac aatgcaggcg atttcccctt tcgccacgct caatgaaaca tccttcaata 2902201 ctggaacttc attctcacgg cccttttttc cgatcgtgaa agaatggtcg atatgctgaa 2902261 catcaatcat atgttctctc tcccttacaa aagtttcatt tttttataaa tcgcaaaata 2902321 actaatcaag aaaccgatta ccgcacctgt acccatgcca atgagataac cggcaaagct 2902381 ctcgcttgca gtaaatccaa aatagccgaa gcccatgatt cctatgataa taacgatgat 2902441 ctgcaccggg cggttaagcg gcttccataa gaagaaatat ccgtttcttt cattagacat 2902501 tttaacaaag ctaatatagc cgatgatgta aaaaatgata gtcatgatag ccggaatgac 2902561 taaataatat ggtgaattct cagcccattt cgagtctaca taaattatcg gaatgaaata 2902621 ctgcacccat ttaggtactg gaccatggat aaaatctatt gatccgccaa aaaggatctc 2902681 gaggttgatc acaggcaggc tgatgagtaa aaacggcgaa atggccacgg taaatgagac 2902741 tagaagctgt gcgaaactat tgcctgtcaa agctcctccg gccataacca aagaataagc 2902801 cagcatgcta acaataatca ttcccaagct gtaattgtga aaataaacgg cctgatctgg 2902861 cttcaaaagc atgatcagca aaacagacaa aacataacct atgagctgcg gcaccacaat 2902921 caccattccg ccggtaagga acttcgcatg aaatatctgc cctcgtgtat atggaaggct 2902981 taatgtaaaa tcaaagaagc tcttgctacg ttcaatccca agctggctga ccgccaaaac 2903041 gactccccaa atccaaaaca atgagataaa tgagctattt aaataatcaa cgctgaatac 2903101 gcaggggccg acccaatttt cttttccagt gacacagcct tgatagatga gatacatatt 2903161 taaaattgat aatggattac ctaatataaa aaccaaaatg gtgataacta aggcgacttt 2903221 attctgccgc cactctttgt aaagcagtcc ggaatccggc aactcacttc cctccaaacc 2903281 taaggcattt cttacacttt tgttttctta taaatagaga agtagctcac aaagaatcca 2903341 gccactgctc caatgatcat acccaaaata taaccaataa tggaatgtcc ggtatagtat 2903401 ccaaataaac caaatccaag gatgccgaaa gccataacca gaatttgcac cgggcgatct 2903461 aatctgttcc ataagaaaaa gtgtccgttc cgttcacttg gaagcttctt gaagcttata 2903521 aagccaatca agtaaaatag catgctcatt acggctggaa tcaataaaag atatttactg 2903581 ttaatcagcc attcatttac aacgtaacta atcggtacta ggttcgataa attgcttgcc 2903641 agagagaaat aactctcagg ggaagggaat atttcccata tattcgcacc aaaaacaact 2903701 tctaggtttc caaccggcaa tgcaataatt aaatacggca atatagctgc tgaaaacgcc 2903761 gttaacagtt gggcaaaagc atttccagtt aacgctccgg cggccatcac cagtgaaaaa 2903821 gccataaaac ttatcacgat tactccaatg ctgctgtgct caaaaaagta gacgtgttca 2903881 gggttataga caagaatcag cagccatgca agtaaaaagc caatcaattg tgacagcaca 2903941 atcacaaaac cgcctaacca aaattttgtc tgaaaaattt ggcttctgtt atacgggagg 2904001 cttaatataa aatccatcgt gcctttcgaa cgctccattc cgaggaagca gaccgccaaa 2904061 atgacacccg gcacccagtt gatatctatc agattgctta tggaataatt cacaataaaa 2904121 tcacaatatt gcgggtcttg gcgatcaaga cacccttgat aagacaaata cgtattaacg 2904181 atagaaagcg gatttgccaa tactaaaaac gcgatactta acaaaatcac cacttgattc 2904241 tgcttccact ctcgatagag gagacctcgg tctaccatct ccgcttccct ccaaacttcg 2904301 caatgaacac ttcttccagg ttgacaggaa gctcattcca cacttttggc ttcagctctc 2904361 tcaaaaagct ctttttctcc tcatcgcttt tcggaatcag cactgtgtaa aacacgccgg 2904421 cctgatcgag catcggaatg ttttgctctc tgatggccaa attgacatct gtatcgaagg 2904481 ccatttgaat tttaatgtat tcttctttta actcatcaag atccatgacg ttggtcaggc 2904541 tgttatcttc aagaaaacca attcggttgc acatccgctc tatgtcttca agccggtggg 2904601 acgtaatcag gatgctcgta tcacgctctg ccacttcatc gaccatcagc tgcagcacat 2904661 catgccttgt caccgcatca ataccatccg tcggctcatc aaggaggatc agcgccggtc 2904721 tcgccgcaaa cgacagaacg agcgatagct gcttttttaa gcctgtcgac agctcacggt 2904781 attttttcgt ttccggaatt tcgtatctgt tcatcagctc attcgcgtac gtgacatcaa 2904841 atttcggata tattcttctc aaaatatcga ctaactgctt gtatgtatac ttatcgtaaa 2904901 acggattttg aacaggcatg tagatgatat tttgtttgac tttcgggtgc tttttgattt 2904961 ctacgccgtc aaataaaatc gttccgctgt cagcgaaaat gatttgctgg attaagcgaa 2905021 gcatcgtcgt tttgcccgat ccattgcgtc caagcaatcc aaagatttct cctttttcga 2905081 ttgttaatga aacatctttt aatacttgat tgccgtcaat cgcttttgac agctgccgca 2905141 gttcaatcat tttttttgcc tcccttcaca tcagcgctga tttcctttat ccattcgtgc 2905201 agtttttcca gctcaacccc tgcatagtgt gcatcgatga tgagctgttt gagttgctct 2905261 ttaatcatcg tcatcttccc ttcaaccagt gtcgtttttg cattctccga tatataggtc 2905321 cctctgcccc gcagcgtttc aataatcccc tctcgctcaa gttctttata cgctttgctg 2905381 acagtgttcg gattcgcaat aatgatcgtt gccaattctc tgacagaagg aagcttatca 2905441 ccaggcttca tgatcccttt caaacaaagc tctttcattt gctgaataat ttgttcgtaa 2905501 atgggtgttg agcttcttgg atcgatttga atcatttact tccctacttt ctatacgatc 2905561 tgaacctttt atagataaaa atgatcaatt atactttttt gccattcaaa accgatcatc 2905621 acaagaacaa gaaaaaaaga acaagcgatc acagatgccg caatcagcat tggcacgtta 2905681 cgtttgtttc gttttttatg tttcataact gcctccctta atgtcaatat ataaatgatt 2905741 ttatattagt gtctatagtg tattacttca attagtacac ttaatacaat aaatactttg 2905801 actcacaaag tcaatccttt ttttacaaaa aaacggaccc ttttaaaagg gtccgttttc 2905861 ctacacatca agagggtgct gcaggatcat attattttgc aaagattgaa gctgaagtct 2905921 cattctgtac agctgttctc tctgctgatc atttgacgac agccatagtt tattcaaggc 2905981 atttaccgca tcttctagct gcatttgtgc atcactatat tcttgatcgt tataatgctc 2906041 ttgtttagaa gcgattttca gctgttcttc agcataatca taggcctgca tacattgctg 2906101 gagatgttca tctactgatt gtcttgttgc cacagtaacc cctcctcttg gtaatggaaa 2906161 tcatccatca ttcatattgt agcctcatct gactttattc aataaagtaa tttatggtcg 2906221 atattcattt gttctcttgt gaaatgcgtg ctacaatttt aggatgcaat cgtacgcaag 2906281 gaggcacatg aattgtgatg cagaacaatc cttttcctta ttcaaatacg gaaaaacgct 2906341 atcatacatt gaattatcat ctcagagaac atttcggcca taaggtgttt aaagtagcgc 2906401 ttgacggcgg ttttgactgt ccaaatcggg atggcaccgt agcccacgga ggctgtacgt 2906461 tttgcagcgc agcaggctcc ggagattttg ctggaaaccg gaccgatgat ttaattacgc 2906521 aattccatga catcaaaaac cgcatgcacg aaaaatggaa ggacggcaag tacatcgctt 2906581 attttcaggc tttcacaaac actcacgccc cggttgaggt gcttcgtgag aaattcgaat 2906641 ccgtcctcgc cttagatgat gtggtcggca tttcgatcgc cacacgcccg gactgtctgc 2906701 ctgatgatgt cgttgattac ttggcagagc tgaatgaacg tacgtatttg tgggtggagc 2906761 ttgggcttca aacagttcat gaacggactg cacttttgat caaccgcgca catgatttta 2906821 actgctatgt ggaaggcgtc aataaattaa gaaaacacgg catacgtgtc tgctcgcata 2906881 ttatcaacgg gctgcctttg gaagaccggg acatgatgat ggaaacggca aaggccgtcg 2906941 cagatttgga tgtccagggc attaaaatcc atctgcttca cctactgaaa ggcacgccga 2907001 tggtcaaaca atatgaaaag ggcaagctgg aatttctttc tcaagatgat tatgtgcagc 2907061 tcgtctgcga tcagcttgag atcattccgc ctgaaatgat cgtccaccgc attacaggtg 2907121 acggaccgat tgagttgatg atcgggccaa tgtggagcgt caacaaatgg gaagtgcttg 2907181 gcgccattaa taaagagcta gaaaatcgag gcagctatca aggaaagttc tttcaacggc 2907241 ttgaggagga atcagcgcta tgattttgaa gaaaattctt ccttacagca aagaactgct 2907301 gaaaatggcc gcgggagagg gagatattgt cgtagatgcg acaatgggca acggacatga 2907361 tacacagttt ttagcggagc ttgtcggtga aaacggccat gtatacgcat tcgacatcca 2907421 agaatcagcc gtggccaata caaaggaacg gctcggtgac atgtatcaag cgcgaacaac 2907481 gttatttcac aaaagccatg ataaaatcgc tgaatccctc ccgcctgaaa cacatggcaa 2907541 agtggcggcc gcggtattta acctcggcta tttgccgggc ggggacaaat caattacgac 2907601 aaacggcagt tctacgatca aagccattga acagcttctc agcatcatga aagacgaagg 2907661 tctgattgtt ctcgtcgtct atcatggcca cccggaaggc aaagctgaaa aaaacgacgt 2907721 gctcgagttt tgccgggact tggaccagca aacagcccgt gtattaacat acgggtttat 2907781 caatcagcaa aatgacccgc catttattgt cgccatcgaa aaaaaagctc agatcagcaa 2907841 atgatttgag cttttttctt tgaatttttc atccaggaca ttttttgaaa tttccggtag 2907901 gctctgccgt tgatataaaa gaaaagggag gtttttccgc tggctttgat cagcttcttt 2907961 gcgagccggc ccatttcctt ttggcctgcc actttatcat ctgacaaata aacgccaagc 2908021 aagccgcgat tgattaaacg atggaagttt tcatgcggaa tgccttgtaa atgctcgtcg 2908081 gctttatgga taaagtgttc aagccggtcc atcatctctt catgagactg ataatacgag 2908141 cagaaattca agtctccttc cagcaagtcc tcctcttgat caatcaaata atcaagaaga 2908201 atatgaagac cctgtatgta aggaaaataa ctgtctcgga tttttttagc ggtgctttct 2908261 gtgaaatcag gctggaacga atacgcaacc agacagaaaa tgcctaacgt tgagcctgca 2908321 caggctgaaa attcatacca ttccatctca ggcagctctg attcatattg agtaaaccac 2908381 ttttcaagcc gcggaacacg ctcatgctca ataacgtgct tatgcacctg caaatcgcaa 2908441 taatagccgc acagttcaag cagataaggt ttaatcatgt catagtgctc aatggagccg 2908501 agaacacgct ggcacgtttt aaccagttca tgcaaatatc cgctgtcatc ctgttcttcc 2908561 ctgaattgat aatagttttg cagttccgcc ccaactgtca gtgcgtcctg cattgaggca 2908621 tggagcatcc gaaaatcctg cgggtccagc gaggtgctgc ggtcacacag attgtccaaa 2908681 taatcactaa tcgtttgata cgcgatgata aactcgacac atttctgctt ttggctgcct 2908741 gacaataagg ccagtatgcc gccgccttca cagtgaaacg ttttgtcccg aatacttgcg 2908801 gttgcctgtg ctttcaattc actgttatga atcgattctg atttttgctt ccatatgtcc 2908861 agctcttgat gaacgagcgg aaaaatatct cgatatacct ttgccatcaa tccaaaagga 2908921 tgttccggta ctgtcaacac atgcaccccc tactagttca aatatattga tcagtaaacg 2908981 ctcttgctgc tttaaaaaca tcttctctct cgggttcatt gaagatctca tggtaaagcc 2909041 cttcccactc tctgtatgct ttattatgag aagcaacacc attaaaccac ttgatgacca 2909101 tcgttttgtc aacaagcttg tcatcaccgg cttgcatcac aagaagcgga actttcaaaa 2909161 atgcctctgt cggcaccatt gccgattcaa ttgtctttaa aagctctctg taccatctga 2909221 cagaaacttt cctgacgtat aacgaatcat tttggtcagc ttcgatgacg tcctcattgc 2909281 gcgtcgccat atcaattgat aatcccgaat caaccttaag tgacggagcg atgacattca 2909341 ggccttttga tgcaagatca agcgctttat tcactttaat ttgcagtccg agacacggtg 2909401 atgataaaat aattcccgta atccggggat ttctttgctg tttaacccat tcaatcgcga 2909461 ccagaccgcc catgctgtga cctagaagaa aaaccggaag atcaaaggtt cgcgctttat 2909521 ctatccaagc atctacttca tcaatgtatt cttgaaacga gcgaatatgc cctctcgctc 2909581 ttgtcgttgt tccctgtcca ggcaaatcgc ccatgacaac gtgataaccc gaagaccgcc 2909641 acatttcaat cagccattta tatcgtccgt gatattcact tgccccgtga atgattacaa 2909701 tcacggcaac aggtctgtct gctttccagg tccacatgat cttcacctca tacgaaattt 2909761 aaatagagaa agaaggatga atcttatgat ctacccttat aaggaacaca agccagatat 2909821 ccacccaaca gcctttatag ctgataatgc aacaattacc ggtgatgtcg tgatcggaga 2909881 acagtccagc atttggtttt ctgttgtcat aaggggagat gttgcgccga ccagaatcgg 2909941 aaacagagtc aatatccaag atttaagctg cctccatcaa agcccgaaca agacgctact 2910001 cattgaagat gacgccacga taggccatca ggttacactt catagcgctg ttatccgcaa 2910061 gaacgcctta atcgggatgg gctcaatcat tttagacgga gccgaaattg gcgaaggcgc 2910121 ttttattggt gccggcagtc ttgtcccgcc cggaaaaatc attccgcctg gccatctcgc 2910181 ctttggccgc cctgcaaaag tcatccgccc tttgacggaa gaagaccgaa aagatatgca 2910241 aagaatacgg tcagaatatg tagaaaaggg ccaatattat aaatttcttc aacaaacata 2910301 agacctgctt cgtcttactt taccattttt caaattatat ttgaaagcaa taaccatcgt 2910361 taacccggac gtcatacagt tcgggtttcg atttttccat aaaacgttca catatagcat 2910421 gaaacgtatg acttttatct tatcacaaaa ctataaacag cctctgcaaa aacacatacc 2910481 tattctttcc tgttctctat tttctatgag cacacacaaa aagagcccac tgggagctct 2910541 ttttgtcagc tgatatttcg ttcgctggca gcagccgcat tttttttatg aaaccctttt 2910601 ccatagtaca cagccagcaa gatgagaaac catatcggcc cgataatcac ggctactctt 2910661 gtatcagggc tgtaagccat aagaatgacg acgaatgcta gaaatgccaa tgacacataa 2910721 gacgtaaacg gaaataaagg cattttgtac tttaattgtt tcttttcttc cggcttcaaa 2910781 cttttcctgt attttatttg agaaagcaaa atgattgccc acgtccaaat cgctccgaac 2910841 gtcgcaatac ttgtaaccca agtaaatacc ttcgcaggga caacatagtt taacagcact 2910901 ccgactaata aagcgcccgc tgaagccaga acagctttac ccgggatgcc gcctttcgtc 2910961 agctgaccat atgcttgtgg cgcctctttc tgttccgcca agttaaacag catccgccct 2911021 gtgctgaaaa taccactgtt gcatgaagac agcgcggctg tcaacacgac aaagttaatg 2911081 atacctgcgg ccgatggaat gcccactttt tgaaatgtga gaacaaatgg acttccttga 2911141 gagccaattt cctgccacgg ataaatagac ataatgacaa ataaagcgcc tacataaaaa 2911201 atcaaaatcc gccaaaatac tgtatcgatt gctttggcta acgatttttg cgggtttttt 2911261 acttcgccag ccgtcacccc gatcatttca atccctaaat aggcgaacat gaccatttga 2911321 agagacaata aaaccccttt taatccatga gggaaaaatc ctccgttgtt ccacaaattg 2911381 ctgattccgg ttgcaatgcc cccattgccg actcctgcaa taatcatcaa taaaccgaca 2911441 gcaatcatgg ataagattgc aacaatttta atcaatgcga accaaaattc cagctcgccg 2911501 taagctttga cagccaggaa attaacaccc gtcataatga ccagtgccga taacgcccaa 2911561 atccagtttg gcacgtccgg aaaccagaac cccatataga tgccgacagc agtgatttcg 2911621 gccatacagg tgacaaccca taaaaaccag tagttccaac ctgttaaata gcctgcaagc 2911681 ggtcccaaat aatcacgcgc atacctgctg aaggagcctg cgaccggttt ttgaatggcc 2911741 atttccccaa gcgctctcat aataaaaaac atgaccaggc cgcttgcggc atacgctacc 2911801 aaaataccag gccctgctaa ttgaatagct gatgcggagc cgaggaacaa ccctactcct 2911861 atagcagctc ctaaagacat taaagaaata tgcctttctt cgagtccgcg gtgcagctct 2911921 tgtttttgtt tttgcatgct tcttctcccc tagaaaaaaa tatcattata tcatttttct 2911981 gaatattccg tacggattgg gtaaatcaat gatgatggag aaataaaagg ataacaacaa 2912041 ggctttcgac tactcgaaag ccttgttgtc tgttacacaa agatgacttc tttaggctga 2912101 tggctcagct cttcaggcat ataccgtttt tcaatattga tgctgtgcca gatcataaag 2912161 attagcacag tccaaatttt acggctgtta tcagccttgt ccgcacaatg gtcttcaaga 2912221 agctgaagga cataatcctt atggatataa gcatccgttt ggctttcttg aataatattc 2912281 cgcacccatt cgttcatttc gtttttcagc caatgacgga tcggtacagg gaaaccaagc 2912341 tttttgcggt ttaatacgtg ctcaggcaca attccttcag cggctttgcg aagaagatac 2912401 ttcgtcgtgc cgttcttcgt tttcagctca tcaggaattt ttgaagcgac gtcgaatacg 2912461 actttatcca agaacggcac acgcagttcc aaagaattcg ccatcgtcat tttatccgcc 2912521 tttaacaaaa tgtcgccgcg catccaagtg tggatatcga catactgcat tttgttgata 2912581 tcgctgtacg agctgctttc tgtaaagtaa gtcttcgtca catcgcgata tgaaaggttc 2912641 ggattataat gcttcaacag ctgctttttg acagactctt caaagatttt cgcgttaccg 2912701 atataacgat cctgaagcgg agtgcagccg cgctcaagca ggctcttccc tctcatacct 2912761 tcaggcataa cggcagcaac gtgcagaagc atctttttca agccggacgg aatccgttca 2912821 aacggtttaa gcgaaagcgg ttcacggtaa atgttatatc cgccgaagag ctcatccgct 2912881 ccttcacctg ataaagcaac cgtaacatgt ttttttgctt cttttgcaac aaagtacaac 2912941 ggaatcgctg ccggatcagc aagcgggtca tcaaaatgcc atacgatctt cggaagctca 2913001 ttcatgtatt cctcaggcga aatgactttg ctgatatttt caatgcccag cgccgctgcc 2913061 gtttctttcg ctacatcaac ctcactgaag ccctgctgtt caaagccgac agagaatgtt 2913121 tttaagcttg gatgaaattc cttcgcaaca gacacaataa aggaagaatc aatcccgcca 2913181 gacaggaacg aaccgacagg aacgtcactt ctcatatgaa cgtttacaga gtcatagatc 2913241 gcgtctcgga cttctttcac aagcttgtct tcttcagtct gaaccggctt gaagttcgct 2913301 ttgaaatacg ttttgaatgt gatatcgccg tccgggcgga ttgtgaattg tgaacccggc 2913361 tctacttttt tcacatgggc atcaagcgtg cttggttcag gaacaaattg gaaagacatg 2913421 tactgctgca atgcctcttt atctatttca atatcattct gagcaaccat taaacttttt 2913481 ctctctgagg caaaataaac ctgatcattg atcgttgtgt agtacaacgg tttaatgccg 2913541 aatggatctc ttgccccata aagcacatga tcgtttttat tccaaatcag aaaggcaaac 2913601 ataccgcgca gtttggacgc cgcttcttct ttatagtgac ggtaagtcgc aagaagaacc 2913661 tctgtgtccg aatccgtgtt gaatgtgtac ccctttgctt caagttcttc tctcagttcg 2913721 atatagttat agatttctcc gttaaagata atccaatatg tttcatcttc atatgataaa 2913781 ggctgtccac cattttctac atcaataatg ctgagccgtc tgaatccgaa gccgacgtgc 2913841 tcatcatgga aatatccatc actgtcagga ccgcggtgaa cgatcatttg gttcatttgt 2913901 ttgattagtt cttcttgatc agcggtttga gctaacggat gcttgttaaa aaccccgaca 2913961 aatccacaca tagtattgcc tccataatta aaattgtcat cattgaaccc ctatttatag 2914021 acgctgtgaa tagtatttgg tttcacagtt atgtaaaaaa ataaacatga atacaacgat 2914081 aaaaaaggga aagccgctta accagtaagc ggctataaaa ttattctcct aacgcttctt 2914141 tacgcagctg ctccgctttg tctgtgcgct cccatggaag gtcaacatcg tgacgtccaa 2914201 agtggccgta cgcagcagtt tgtttataga tcggacggcg caaatcaagc attttgataa 2914261 tgccggcagg tcgtaaatca aagttattgc gaacaacttc aatcagtttt tcctcagaag 2914321 cttttcctga accgaatgtg ttgattgaga ttgacacagg ctgtgcaaca ccgatcgcgt 2914381 aagcaagctg tacttcgcaa gaatcagcaa gctcagccgc aacgatgttt ttcgcaacgt 2914441 atcttgccgc ataagctgca gaacggtcta ccttcgtcgc gtccttacct gagaacgcgc 2914501 ctccgccgtg gcgtgcatag ccgccgtacg tatcaacgat gattttgcgt cctgtaagtc 2914561 ccgcatcccc ttgagggcct ccgattacga aacgtcctgt agggttgatg aaatattttg 2914621 tttcttcatc aatcagctct tcaggaacaa ccggattgat tacatgttct ttaatgttgc 2914681 gctgaatttg ctcaagtgta atttcagggt gatgctgagt tgaaataaca atcgcgtcaa 2914741 tgcggactgg tttgttattt tcatcgtact caaccgttac ctgtgttttg ccgtcagggc 2914801 gaaggtacgg aagaatatct tctttacgga cttcacttag gcggcgggct aatttatggg 2914861 caagtgaaat tggaagaggc ataagctctt tcgtttcgtt gcacgcataa ccgaacatta 2914921 atccttggtc acccgcacca atcgcttcaa tttcttcgtc gctcattgtg ccttcacggg 2914981 cttcaagcgc ttggtctacg cccatcgcga tatcagcaga ctgctcatca attgatgtta 2915041 aaaccgcaca agtttccgca tcaaatccgt attttgcacg tgtgtatccg atttctttaa 2915101 tggtttggcg aaccgttttc ggaatgtcaa catacgtaga agttgtgatc tctccgctta 2915161 caagaaccaa acctgttgtc acagatgttt cacaagcaac acgcgcgtta gggtctttct 2915221 ttaaaatttc atctaaaatg ctgtcagaaa tctggtcaca gattttatcc ggatgcccct 2915281 ccgtaacaga ttctgatgta aataaacgac gatttttact catgatttgc ttcctcctgc 2915341 acaaggcctc ccgaaagacc ttgtatatat gatacggaac tcgctccctc ttatacaatg 2915401 tacagttata ttagagaatg ttaattggca tatttatgaa ataaaaaaac cttttccatc 2915461 gaggaaaggg tttggtcttt gtgcctttca ctcttatcgc tcaaggaatc atacaacctt 2915521 gcaacaggtt agcaccttgg ttgtctcact cagttgaaca taataaataa cagagaaacc 2915581 ggttgctggg cttcataggg cctgtccctc cgccagctcg ggataagagt atccgctcaa 2915641 tgaaatatct tatcgtaaaa gggtttgcaa tgtcaatatg attcagaaga aataggcacc 2915701 tatattgagg gaaaacaatg gaaatgcaca cacaaaaaac aataaatagt atagactatt 2915761 tgaaaatata tgttatacta attcacaatt agcaaaacac aaaaaacgat aaaggaaggt 2915821 ttcatatgaa ctcagttgat ttgaccgctg atttacaagc cttattaaca tgtccaaatg 2915881 tgcgtcataa tttatcagca gcacagctaa cagaaaaagt cctctcccga aacgaaggca 2915941 ttttaacatc cacaggtgct gttcgcgcga caacaggcgc ttacacagga cgctcaccta 2916001 aagataaatt catcgtggag gaagaaagca cgaaaaataa gatcgattgg ggcccggtga 2916061 atcagccgat ttcagaagaa gcgtttgagc ggctgtacac gaaagttgtc agctatttaa 2916121 aggagcgaga tgaactgttt gttttcgaag gatttgccgg agcagacgag aaatacaggc 2916181 tgccgatcac tgtcgtaaat gagttcgcat ggcacaattt atttgcgcgg cagctgttta 2916241 tccgtccgga aggaaatgat aagaaaacag ttgagcagcc gttcaccatt ctttctgctc 2916301 cgcatttcaa agcggatcca aaaacagacg gcactcattc cgaaacgttt attattgtct 2916361 ctttcgaaaa gcggacaatt ttaatcggcg gaactgagta tgccggtgaa atgaagaagt 2916421 ccattttctc cattatgaat ttcctgctgc ctgaaagaga tattttatct atgcactgct 2916481 ccgccaatgt cggtgaaaaa ggcgatgtcg cccttttctt cggactgtca ggaacaggaa 2916541 agaccaccct gtcggcagat gctgaccgca agctgatcgg tgacgatgaa catggctggt 2916601 ctgatacagg cgtctttaat attgaaggcg gatgctacgc taagtgtatt catttaagcg 2916661 aggaaaagga gccgcaaatc tttaacgcga tccgcttcgg gtctgttctc gaaaatgtcg 2916721 ttgtggatga agatacacgc gaagccaatt atgatgattc cttctatact gaaaacacgc 2916781 gggcagctta cccgattcat atgattaata acatcgtgac tccaagcatg gccggccatc 2916841 cgtcagccat tgtatttttg acggctgatg ccttcggagt cctgccgccg atcagcaaac 2916901 taacgaagga gcaggcgatg taccattttt tgagcggtta cacgagtaag cttgccggaa 2916961 ccgaacgtgg tgtcacgtct cctgaaacga cgttttctac atgcttcggc tcaccgttcc 2917021 tgccgcttcc tgctcacgtc tatgctgaaa tgctcggcaa aaagatcgat gaacacggcg 2917081 cagacgtttt cttagtcaat accggatgga ccgggggcgg ctacggcaca ggcgaacgaa 2917141 tgaagctttc ttacactaga gcaatggtca aagcagcgat tgaaggcaaa ttagaggatg 2917201 ctgaaatgat aactgacgat attttcggcc tgcacattcc ggcccatgtt cctggcgttc 2917261 ctgatcatat ccttcagcct gaaaacacgt ggaccaacaa ggaagaatac aaagaaaaag 2917321 cagtctacct tgcaaatgaa ttcaaagaga actttaaaaa gttcgcacat accgatgcca 2917381 tcgcccaggc aggcggccct ctcgtataaa aaacaaaagc caagagcaat tatgctcttg 2917441 gcttgtttta attgacggaa tgcaaagaag tcagcttgta tgtaatgatg gtccggcctt 2917501 cttcccattg aagcttctgc acttcagctg tgcctgactt ttcgccaaac tttgttttgc 2917561 gtacatccat tggaatctcc atcggatata ctcggtatcc gtccttctct aacgtgaata 2917621 tattttcatc tatgcgaact tcttttcctt ttgtcacaat cagtgtatta aattcaacag 2917681 gcattcccaa agtgaaatcc cctttcgttc tcttttttct ttatcataac atatttcact 2917741 gtcagcggtt tttcatccat tgtgtgagct gccgcacgat acgccggttt tcttttggcg 2917801 ggaaataatg tgtgaatgta ctgtagtacc atgtttccac cggcttatgc agttgtttta 2917861 gcttctcttc taataaatag gaatgctgaa tcgaaacatt ttggtctttt tctccatgga 2917921 ttaacagcac gggagcctga attttgttta cttggtcaaa cggtgtcctc cattgatatt 2917981 cctcaggcac ctttttcggt gttccgccga tgactctttt catcattcgc cgcaaatcct 2918041 gccgctcctc gtatgtaaga atcatatcac tgacgcctcc ccaggaaaca aatgaagctg 2918101 cctgcccgcc catttcgatc gcagtgagca ttcccataat tccgccgcgg gaaaaaccga 2918161 agatatggat tctatccttc ttgacatttg ggtgctgctg aagcaggcga aaagcagaaa 2918221 atgcatcctc cctgtcttct ccggcaaaat cctcattgcc ttctcctcct tgattgcctc 2918281 tgtaaaaagg agcaaacacc acaaaccctt gggatgcaaa ctggataatc cggcccggcc 2918341 gaaccatgcc cacgctttta atcccgccgc gcaaatataa aaatccgtca tattgtcccg 2918401 gttccgccgg ctcagccaga agccccttaa cccgtaatcc atttgacaga tagcagatcg 2918461 tatacaaacg cacatgctgg cttggcgacg gaaatcttct tttctctaca atcaaaacag 2918521 ccgcctcctt ttttctatat gctttcctta ctccaaaatt acatccggag aacctggtta 2918581 ggcattcaca catttttata cccatcatac gatatgtaaa gcaaaaaagg atattaactt 2918641 gatgcgaaat aaggaggttg tctatgtgaa cagatggtta aggctgggct tcgcctgtgt 2918701 cggcagtatc tttctgatgt tcgccctggc ggcttgcaag caggaagaaa cgctcaccaa 2918761 agtcaaagta gctgaagtga cccattcaat tttttacgca cctttatatg ttgctgagtc 2918821 taaaggtttt tttaaggaag aagggcttga tgtcgatgtg aatacgacct ggggcggaga 2918881 taaaacgatg acatcgcttc tttccaacgg ctccgacatc gcgcttgtcg ggtcagaaac 2918941 atctatttat gtcgaagcgc aaggggctaa agatcccgtc attaatttcg cccagctgac 2919001 tcagacagac ggaacgtttc ttgtcgcgag agaagatgtt gaacacttcg actgggatca 2919061 gctgaaagga aaaacgtttc tcggtcagcg aaaaggcggc atgccgcaaa tggtcggcga 2919121 gtatgtactg aacaaacata agattgaccc gcataaggat atagacctca tccagaacat 2919181 agacttcgcc aatattgcca atgcgtttgc ttctggaacc ggtgagtatg tacagctctt 2919241 tgaaccgcag gcttctctct ttgagaaaaa aggcatcggc catatcgtgg cttcattcgg 2919301 agaagaatca ggagaggttc cttatacgac ttttatggcg aaacaaagct atttgaagaa 2919361 aaatgaagac acagccgtca agtttacaaa agccatttat aaggcgcagc agtgggttga 2919421 aaatcattct gcgaaggaca tcacagatgc cattaaagat gaatttgatg ataccgaccc 2919481 agacgtcatc gaaacatcca ttgaacgcta taaaaaacag cattcatatt caccagaccc 2919541 tctgcttaac gaaaaagaat gggagcttct ccaaaccatt atggataaat cgggagaact 2919601 gccgaagcac attccataca atcagcttgt aaataaagaa attgctgaaa aagtcacctc 2919661 ggagaaatag gaggcgccat ctatgtcttt cttacatgtc gaccatgtaa cccatactta 2919721 tttttctatt aaagaaaaaa caacggctgt gcgggatatt catttcgatg ccgaaaaagg 2919781 cgatttcatc tcatttctcg gcccaagcgg ctgcggaaaa acaacattgc tttccattat 2919841 tgccggtttg attgagccat cagaaggcag agttctgatt gaaggccgtg agccgaatca 2919901 aaaagaacat aatattggct atatgcttca gcaggattac ttatttccct ggaaatctat 2919961 cgaggaaaat gtgcttctcg gtttaaaaat cgccgacacg ctgacagaag aaagcaaagc 2920021 cgctgcactc ggtctattgc cggagttcgg cctcatagat gtggagaaaa aatatccgaa 2920081 agaactgtca ggcgggatgc gccagcgggc tgcgcttgca agaacacttg cgcctaaccc 2920141 tagtctgctt ttgctggatg agccattttc cgcgcttgat tttcagacaa agctgtcttt 2920201 ggaaaacctg gtattccgca cattaaagga atatcaaaaa acagcagtgc ttgtcactca 2920261 tgatataggg gaagcgatag cgatgagcga tacgatcttt ttattttcaa atcagccggg 2920321 caccatccat cagattttta ccattcctaa ggaattggcc gcgatgttgc cttttgacgc 2920381 ccgtcaggaa ccttccttcc agacactgtt tcaaacgata tggaaggagc tgaattctct 2920441 tgagaaacag caaagaaacc attgatctgc ttcacgagca gtatcaattc aaacagaaaa 2920501 aggaaaagtg gaaggtccat tcctttcagc ttgccatatt tattctcttt ttctcgggct 2920561 gggaaatctc cagcaggcag ggctggatcg atccgctgat cttcagctct ccatcagctg 2920621 tgtggcgatt attgctggag aaacttggtg acggttcttt actgtcacac atcggcgtca 2920681 ctttatttga aacggtgctt ggctttttgc tcgggacgtt tatgggcacg tgcctagccg 2920741 ctttgttatg gtggtctaac cgacttgcca gaattttaga tccgtatctt gtgattttga 2920801 acgcaatgcc gaaagtggcc ctgggcccga tcctgattgt cgcgctcggt cccagtttta 2920861 tcagcatcat tgcgatggga gccatcatca gcgtcattat cacaaccatc gttgtctaca 2920921 ccgccttcca agaggtcgac gaaaactata cgaaagtcat gaaaacattc ggcgcaaaaa 2920981 agtgggttat ttttaaagaa gtcatactgc ctgcatcctc ccccgcgatt atttcaacac 2921041 taaaagtgaa cgtcggttta tcatgggttg gcgttattgt aggggaattc ctcgtttcga 2921101 aggtcggatt aggatatatg attatttacg gattccaagt cttcaatttt acactcgtct 2921161 tcttaagcct gctgatcatc gccatcttcg ccactctgat gtatcagggc gtcgagctgc 2921221 tggaaaagaa atggacgaag gggaggacat aaaaaacccg gcacatgtgc cgggtttttt 2921281 attcaatcca tccagattct ttcagttttt tcaagctgat cggaagaacg gaatccttca 2921341 taataaagct gaatttttta ttgcgggaaa ggttctccgg cagctcgtga aacaaaaccg 2921401 ggcctttcgt ttcaaagtaa tcagcctgct tttcaagctt ttctatatct gcaaaatata 2921461 tattttttac aatcactttt tcttttccga gaactttata ctgtccgaga tacttgaggc 2921521 ttttgactct cgcgcccgtc tcttccttta cttcccggag cgcagcctct tctgcgcact 2921581 ccatcggctc tactttcccg cctggaaact catagcctct gtcctcatgt tctgttaaaa 2921641 gccatttgcc gccaaaacgg caaatcaccc agacatgctt cgggctgtcc gagaaaggct 2921701 gatcgtcaaa ggaaagctga acagtattct gataataatc tttaaactcg tacatgttta 2921761 tccctcaaat ccgttcctag ctatcttcca tacatcatac cacagttacg tttcttcgga 2921821 agccttttat caaaaaataa gggaaaccca gcacgccgtc aggttctgca tgcagactag 2921881 ctcgtacagt ttttttgcga tacttttgcc ggaaagtgcg accgacgctc tgggctttat 2921941 tatgacccgc gaacagggaa aagttacggt ttgcgcttaa atttattttt taacgtttct 2922001 aaaagatcga caagcatctg aggaaccggt atgccaagag agctggctgt cacaacaatt 2922061 tgcacagatt cataaagaat ataaaacata atagccaagt cacgaattga tccctgtgta 2922121 ttcagcagct gatcaaaaaa gtggcataca gagatcagag ccagcgtgac taattttttg 2922181 acaagccggg caaatacctt tttaaatgac agtttgtgaa taatggtttc cttcaaagtc 2922241 gtactgataa attcaattgc cataagagag agcaaaatca gaaatgaata ctgaaaacct 2922301 ccaaagaaaa aacccgctgc tgaaacgctg actgctaaaa acgaaaagat gccaaagtct 2922361 ctatccattt atcccaacat cctttcacag aaacggcctt acgatattct atggtaaaca 2922421 agccgaacgg attggatttt tcagaaaaat ggactggttg tcgcctattt ttcagataca 2922481 aaaagaaaag ccggacgtct tttttaagac atccggccgt tctatttttg aacttaacct 2922541 aggtaagctt ttagcatcca gttatgtttt tcaatatttt gatggatcgc aagaagcatg 2922601 tcccctgttg tttcgtcacc gacttcatca gctaaatcca tgccgttttt cagctcttcc 2922661 gcgatgactg tgaaatcatc atatacgctt tgaaccattt gttcagctgt ttcatttcca 2922721 gcagcttctt tgacagaagc cgtttctaag gattccttca ttgttgcaat cggttttccg 2922781 ttcagcgcca aaagacgttc tgctaagtca tcaatataag ttgctgtttc gttgtacagc 2922841 tcctcaaact tttcatgaag agtgaagaaa tctttccctt tcacatacca gtgataatta 2922901 tgtagtttca catacatgac cgtccagttg gctacttgtt tgttcactgc ttgaatcaat 2922961 tgttctgaca tggtatctcc tccttgttat atgactatgt atacccttaa tatcgtacgc 2923021 taaaacctct tttttaccct tatctgtcac gatttcttct attatgctac aattgttaaa 2923081 aaacgggagg tggaatgtca tgacgcttct cattacgata agtattttga ttgtgctggc 2923141 tgttttgctt gtaaccattt ggacgactgt aaaagcctat aatgtaaagc ataccattga 2923201 tccaccacaa gaaaatcact ctgattcaca caatcaatga tgatgtgaat gctcctcttc 2923261 tgactgattg ctggcagcat cggcgtctcc gacttggact tttaaggtcg gcatgctatg 2923321 ctgttttttt gctgtgacat gagattggac agtgtataca ccatcttcct taaacgtcgt 2923381 ttccaatcgg tatacgcctt tttcttgttt caccttaaac atttggcttg cgtctttttc 2923441 cccttctttc catacttcaa actctacttc atcggcatcc gtcacagctt catcaccata 2923501 tgatacagct gcttcataag cagcgctttc tccgggattt actttttcag gcccggtcag 2923561 cttgacatcc aaaacctcgg gcgtctcagc tgtatttgct ttactttcac cagatccgca 2923621 tccattaagc aataaagcag aaaaaagcag aacaaccaac atctttttca tgccatcacc 2923681 ctttcatcgt ttacctaaat agtagcaaac gcttacagca aatggtacac aaaatatgag 2923741 acgtcacaaa aaagaccttt ttgcttaagc gcaaaaaggt cctttctatt ttagccaaat 2923801 acttttagca attcttcttt atcctgtgaa agccagaaac gcattaaacg tttagcgcct 2923861 tccagatcat gaagcttcgc ttggccgcac tgcttttcat tcgcagcagg tatttctgta 2923921 atctctaccg cttccttcat tgtgtcttca agcagatcaa cgatttccgc tgatgtcggc 2923981 tctccgctca caactagata atagcctgtc tggcagccca ttggagaaat atcaatgata 2924041 tcaaaatgat cgtatttctc agcgtgagaa cgaatcgtaa acgcgagcaa atgctcgagt 2924101 gtgtgaatgg tgtcaggctt catcgcctgt ttatttggct ggcaaaaacg aatgtcaaat 2924161 ttatttacaa cgccgtctgt tcccacttta tgcacgccgc aatgtcttac atatggagca 2924221 acaaccgcat tatgatcaag ctcaaaactt tctactgaag gcataatggc actctcccct 2924281 tttttaaaaa tgtaatttca ttataacata cttttccgat aagaattatt gattaacttt 2924341 tcaatctgtg ttttttttct tatacttgca tcagaaaggt tgctgaagaa acatgaaaac 2924401 cctattcatc gctctgatca gaggatatca aaaattcatc tcgcccctga caccgccaac 2924461 gtgccgcttt tatccgacct gttcccaata tggaatcgaa gcgattaaaa cacatggcgc 2924521 tttaaaaggc ggatggctga caatcaaacg gattttgaaa tgccacccgt tccatccggg 2924581 aggagtcgat cccgttcctg aaaagaaaca aaaacattaa ttgttataac cgtttacgat 2924641 aagatccagt tttccggttt taggatcaat gactaagcca tggaccggaa cgttttcagg 2924701 gaacagcggg tgatgtttaa taacatctac gctgtctttc acactcgctt ccactgaatc 2924761 aaagctttta aaccattgat caaagtctac accggagtac tttattgttt cgatgcgttc 2924821 ttccggaatc cctcttgctt tgattttttc aagcatgctt ttgctgctga ttttgctcat 2924881 gccgcaatcg tgatgcccga tcacacacac ctcatctgca ttcagctcgt acactgcgac 2924941 gagtatactt ctcatgatgc ttccgaatgg gtgtgtcaca agcgcaccgg cacttttaat 2925001 gattttcaca tcaccgtttc gcaaattcat cgcatgcggc agcagttcaa ccagacgagt 2925061 atccatgcaa gaaagaatcg ccattttttt atctggaaat tttgatgttt gatacttttc 2925121 atactctctt tgttcagtaa atgtcttgtt aaattcgaga atatcattta gaagactcat 2925181 gttcgttgtc cctttctatt ctttttactc ttcaatatat cacaaccctt gtttattcgt 2925241 cataataaaa aaagacaaac cctcaggcct gccttatttc cccatgttat agcgtttttt 2925301 gaactgctca actcgtccgc ctttttcatt gaatttctgg cggcctgtat aaaacggatg 2925361 cgtgtcagag cttacctcta ctttaatgac aggatatgtg tttccgtcct cccactctgc 2925421 tgtttcatta gatgttttcg tagaggtgct tagaaaacgg tagccgctgt tgacatcctg 2925481 aaatatcact ttgtggttct ttggatgaat tccttctttc atgggtatct cctttcaata 2925541 aatcgtaata attacgtttt attttataac cttacaaacg ttttgtcaat cttcttatat 2925601 ccttccctct gtttcacatc gtaaacctca tggcatttaa gaataggaag aataatctaa 2925661 ccgaggaagc aaataataaa cccaaaatac atacagaacg tctttttgga aaggtggttt 2925721 acgattgtgg atgatttagt tttggccaga agcctttttg gcacgacgat gggctttcat 2925781 atcattttcg caacacttgg agtcggtctg ccgctcatga ttttagtggc ggaattgatc 2925841 tatcaaaaaa cgaaagatga ccattatgcg atcatggcga aaagatggac gaaagcacaa 2925901 gccgttttgc tgggggtcgc cataccgacc ggaacgatcg cgggcactca gctcgcgctt 2925961 ttatggccgg gatttatgga agtcatcggc cgggtgatgt ccctgccatt tcaaattgaa 2926021 atctatgctt tttttgttga agccctattc atgtcgattt atgtatacgc tgcagaccgt 2926081 ttgtcacctg caatgaggat tgttgctgtt ttctttgtgt tagtcggggc agcagcatcc 2926141 gctgttctga tcacgaatgt tcacgctttt gaaggtacgc ccgccggttt taaaatttta 2926201 aacggaaaaa ttacagatgt tgacccgtgg gctgcgtttt ttaatcctag cttttttatc 2926261 actgccggcc atgtcgtgct gtccgcgttt atgactggtg cgtttatcgt ggcttctgtt 2926321 gcggcgtata aaatgatccg aacgaggaaa aaggaaaggg tctatcgctt tcaccggaaa 2926381 gcccttttgc tcgcactgac gatcggcggt attttttcat tgctgaccgc tttgaacgga 2926441 cacgaatctg cacagatgct gtacgaatac cagcccgaaa aattagccgg tgcggaaggc 2926501 ctatttgaaa caagatccca cgccccgctc gctatcggcg gttttaccga cccgaatgaa 2926561 gaaaaagtaa aatgggcaat cgagattcca tgggctttaa gctttttggc agcgaaccgt 2926621 tttgacactg ttgtaaaagg attaaatgca tttccgagag atgaatggcc gccgcttttc 2926681 attcacacgc tgtttaatgc gatggttggt gtaggcatgc tgctaattct ttattccatt 2926741 atcggtgtgg tctggagaaa ggtgctcaag aaagaccgtt tcccaacgtg gcttttgatc 2926801 attttcatga cagcaggccc ttttagtctc atcggcattg aattcggctg gattttcgca 2926861 tgtacgggga ggcagccttg ggtcatctat catctgctga aaacgtcaga tgtcgtaaca 2926921 acgactggct cgatcggggt gctgttctta tttttcacat ttgtttatgc cgtgttaggc 2926981 gcagctgtcg tctacgtgct gctgtattat ttccgcaagc acccggttga cgaagattta 2927041 aatacagcgg agtcgtaatg gctccgcaaa caggaaacca aatggaagga agatcgtaca 2927101 aatggagatt tcaactgacg ctctgatcgc catctcaatt atctggggct ttgtgtttat 2927161 ttacgccgtc atggcgacaa tggattttgg agcgggattt tggtctatga tctatttaaa 2927221 caaggagcat atgaaggcca ccgatattgc gaatcgcttt ttgtccccga cttgggaggt 2927281 cacaaacgtc tttattgtgg ccatcgtcgt ggcgcttttc agttttttcc ccggcgcgac 2927341 atttgtgctc ggcaccgttt tattaattcc cggaagcatg attttgctgc ttttagcaat 2927401 tcgaagcgga tttctcgtgt tttcaaatac agcaaaggag cggaaaacgc taagatatat 2927461 ttccggcatc tccggcttta tcattcctgc tattttaatt ttggtgcttc ctgtgacaca 2927521 cggagggttt atagaaaaaa cggatggaat ctataactta aatatgtcta aaatcttttc 2927581 aagccccaac gcctattcat ttatcgggtt tgcgatttta agcaccttat ttttgtcctc 2927641 gctgttgctt gcagattttt caaatgtggc agaggaacag gatgcgtacc gagcctacag 2927701 aaaaagcgcc ctgattaccg gcccgatttc actgttgttt gctgtatgca ttatggtaac 2927761 tatgcggaat gaagcaaact ggctgtacag cggaatgatg aatgattttt cttggattat 2927821 tgcatcgttc attacatttg tcattgctgg aatcgctctt tttctgccta acaaaagctt 2927881 tggtcaaaac atcggaaaac cgcgtctcgc acttgttgcg attgggatac agtattttct 2927941 cgcaagctac gcgtacgggc gggcgcatct tccgtatatg atttatcccg atgtgacagt 2928001 catgtcaggc ttcacagagc cagcaacgtt cagagcgctg tttgcaacgt atatcgttgc 2928061 atttatcatt ctatttccgg gcttcttttt cttctggaaa atgtttatgc gagataaacg 2928121 ctatatccgc caggaggaat agagggcaag ccagccggct atactaatcc agaaccttta 2928181 taaggagggg atggcatgga gcagaaaatt ctatgtgagg tcaacaactg ttcttattgg 2928241 ggcaaaggta acaaatgcac cgctgatgcc atttatgttg tcagccatac tggtgaaacg 2928301 gctgaaaaca gccgggaaac agactgcaaa acgtttaagc cgcatgattt ataattaaaa 2928361 gaaagagctg catcagccag ctctttcttt ttgcatgttg agtgttctca gctttttagt 2928421 tatgaccccg tttgcaggtg aaaacaaaaa ggcgcttgca taacatacac ctgtcatggc 2928481 cgccatcgct cctgaaatcg aaacattaag ccacgttgcg aagaaatagc ccatgaccgc 2928541 cgacagcccg ccaatcaacg cgctgagaat cagcatataa agaagccggt ctgtcagcaa 2928601 atgtgccgca gccggcggaa caatcagcat ggccacaacc aatacggcac ccaccgaatc 2928661 aaaggaagca acagtcgtca aggacagcat gcccatttgc acgtaatgaa tgagcaaaac 2928721 cggtattccc aaggctaaag ccatttgagg atcaaacgaa gcgattttaa actccttata 2928781 gcacacactg atcaacacta cgtttaaaac cagaacagat gccagcatcc aaaacgcttt 2928841 cggcccaata tcaaccccga ataccgtcac cgtattccac ggcacaaaag cgatttctcc 2928901 cattaacgag tgctcaatat cgagatggac attcgctcca tacacagaaa gcaaaataac 2928961 cccgattgca aataaggatg taaacacaac tcctatggca gcatctgatt gaaccccctt 2929021 gctatgaaga agctgaacca agaaagccgt taacagaccg gttgcggctg cgccaataaa 2929081 catataaatc ccatcgagac ttcccgtcac tagaaaagcg ccgacaatgc caagcaacac 2929141 tgtgtgactg attgcgtcgg ccagcatcgc catgcttctc agcacaagaa atgtgccgat 2929201 caatccgcag cttacaccga ctaatacacc ggtagctata atccatgctt caaaactcat 2929261 ttgcgatctg tcccttctcg gcatcatgag acgcttttcg acgctcaggc atccgtccat 2929321 acagctttaa gagtgaataa agccgctctc tcgtttctct cggtaaacgg tccgggtcaa 2929381 agtagtcctg atcggattct atattggcaa gttccatttc atgcatgaga tacacttcat 2929441 acatccgctg cttcaaagct gtgtgatagc ctttttctat ccctttgctt gtgatttgcc 2929501 aaatcccatt ttcgatacgc tcaatgcacc tctcttgttc caagtcattt aatgccttaa 2929561 ggcataatga aggggatagg cgtcttttct ttcttacact ttcaacagtt acacaaagat 2929621 tattcttttc atactgttca taaatcgcca aaagcacttg ctccctgctt gttctgcgcc 2929681 gcagcctcat cagccttatg gctttagcag ccaatccccg cttaggcgcg caaatcattg 2929741 aaaaaagaaa gagcagcgtt gcagataaga tcattaatgg ccctgtcgcc attcccttca 2929801 tcgtggtgct aagcagggtt ccggccactc cgctgacccc gcctgtaatc ccggcaatga 2929861 tgatcatccc ggttaatcgt tcggtccaat atctcgcggt tatggcaggt gtaatcagca 2929921 tagccgccat taatatcaca ccaacagtct gaagcccaat gacgacagca cagacaatca 2929981 gacaagccaa aagcccgttt aaaaaacgca ccgggattcc taatcccttt gcaaacgcga 2930041 gatcaaaagt aatcaatgta aattccttaa agaaaacaat acataggagc agtagaacag 2930101 cggatatccc tgcaataagg atgatatcct gcctgaccaa tgaagcagcc tggccgaata 2930161 aaaaagaatc aagcccgctt tggcttcccg ccccctgttg ctgaatatat gtcagcagaa 2930221 tgatcccgac gccaaaaaac acagaaagaa caatcccgat cgccgagtcc tcctttgttt 2930281 ttgaaagccg aggaatcagc tgaatacaaa acgttccgag cagtccggcg agcgctgccc 2930341 ccagcaaaaa gaaaggcagt gatttttgcc cggtgaacag aaaagcgaga cacactcccg 2930401 gcagagctga atgggccatc gcatcgccga ttaaactttg ctttctcagc agcacaaagc 2930461 tgcccaaaac accgcttgcc gtcccgagca aaagcgtacc ggccagcacc cactgtgtat 2930521 tcggatgctg aagctgcagc cacaaacttt caaacattgc gctcactcct tatgtccttc 2930581 tgccagcact ttatctttta aaaacgtaag ccttcctcca tatgtttttt gcaggttttc 2930641 gatcgtaaaa acgttttccg tcggtccgaa agcgattttc cttaaatgaa gcagtaagat 2930701 ccaatcgaaa taatcctcgg cggtctgcag atcatgatgg acgacaagca cggtttttcc 2930761 tttttctttg agttctgcca acagcgtcat aatcgcgcgc tccgtcgctg catcaacacc 2930821 tgcaaacggt tcatccataa aataaatgtc agcgttctgg cagagtgccc gggcaagaaa 2930881 cacccgctgc tgctgtccgc ctgacagctg gctgatttgc cttttcgcat aatcatgcat 2930941 cccgactttt gttaatgcgg ccttcgccat ctccacatcc gctttctttg gcctctttaa 2931001 taaaccgatt ctcccgtatc ttcccattag gacgacatcg agcgggcttg tggggaaatc 2931061 ccagtcaacc gagccgcgct gcggaacata tccgattctg gtccgctgat ccttatagtc 2931121 tttgccgtaa atagagatgt ctccggaagc tctgggcaca agaccgagaa tcgttttgat 2931181 caaggttgat tttcccgcgc cgtttgggcc gataatgcca ataagttttc cttcaggcac 2931241 ctgcagcgaa atgtcctgca gtacaggctt tttatgataa gcaaccgtca cattatcaag 2931301 ctcaacaggg aacatatcct ccacctcttt tctttattta agcgctttag taatcgtgtt 2931361 gatattgtgg cggaacattc cttcgtatgt gccttctttt gtgccctttt cacccatggc 2931421 atccgaataa agctgaccgc cgattgtgac tgtatggcct ttttctttag cgccttccac 2931481 cactgcattg attgattttt cagatacact gctttctacg aacacagctt ttatttgttt 2931541 ttctgtcaga agatcaacca gctcctgaac atcccttaat ccatagtccg aatctgtgct 2931601 gagtccctgc aggcctttta ccttaaatcc atactcattc ccaaagtacg caaacgcatc 2931661 atgagcagtc acaagcacac ggcttttctc cggaatatgt gcgatctcct tacgcgacca 2931721 cttatctaaa tattgcaaat cttctttgta ctctttggca tttttccgaa aggcatctgc 2931781 gtgctgaggc attgctttgc tgaattgcgc ttcaatttca tccaccgcat agatccataa 2931841 cggaatgctg aaccagacgt ggggatcaaa cgtcttgcct tcccccgcgg gaataagctt 2931901 atttttcgga atggcctcag ctactgccgc cgattgtttt tgttcgccga ttttttggag 2931961 gacatcctcc attttccctt ccaaatgcaa cccgctgtac agaacaacat cggcagacat 2932021 taattttttc gtgtcacctt gggaagcttt gtaaaggtgc ggatcaaccc ccggtcccat 2932081 taaagaggtg acttttacgt gcttacctcc gatgttttct gctgcatcgg caatttgaga 2932141 tgttgtcgct gtcacttgta attgctgatc agcgcttttt ccggctgaat ccgttccgca 2932201 tcccgttaaa gcaaaggtcg caaaaagtac tgctgccatc agcccttgtc tcatatttct 2932261 cctcctcttt gccatcaatg tccgattgtt ttatcttatg ttgtcagttc ttagacatgt 2932321 gacattaaat tagccaaaag catgttttat ttacacagga caaaaagttt ccctcatgca 2932381 aaattatcgc gtttggccat ttttgtcaag ctgatttaca taaaaaaacc ggctgggtca 2932441 gcagccggtc caaacgagaa gggatgtatt caacgaacac ttttactgta acagcacagt 2932501 gtcatttatt caaaatagca aaatgctttt ttcttaacca tgctgtgtga aaacatccat 2932561 tttggtcaca tattttcgca taatatcttg gtttacctca acccctaaac caggctgttt 2932621 tgacacagaa ataaatccat tatcaatacg aatatcagga gttacaatat cttcatccca 2932681 atagcgtgag gatgaagata tatcgccagg tattgtgaat tgaggcagtg aagcaagcgc 2932741 cacgttctgc gctcttgata tgcctgtttc cagcattcct ccgcaccaaa cctgcatatg 2932801 atgctctttg cataaatcat gaatttttaa ggcttctgtt aagccgccga cacgagaagg 2932861 ttttatatta ataattttgc agcttcctag ctcaatcgcc cgtctcgcat catcaactga 2932921 acaaatgctc tcatcaaggc aaatggccgt tttcaaatgt ttctgcaagt ggcggtggtc 2932981 aacgatatcg tcagcttgga gcggctgctc aatcatcatt aaatgatagt catcaagctc 2933041 ctttaaacgg ctgatatcct tcagttcgta agaggaattg gcatcggcca taagcgggat 2933101 ggttgggaat cggctgcgga tggccttgac caattccaca tcctgcccag gctgaatttt 2933161 aatttttatt ctttgataac cttctttttg atagctctca atttccttca gcatatcgtc 2933221 aagaggcgcc aggccgacta ccaccccggc agggacttta tctcttgttc cgcccaatgc 2933281 ctcagcaagg gatacgccct tctttttggc ataaatatcc catacagccg attcaagtcc 2933341 cgcttttgcc atccggtttc ctttataccg cgccaggctg tccggcactt ctgaagggtg 2933401 attgaattca cggccgacga catttgggat aaaaaaatct tttagcatat gcaaacatgt 2933461 tccaatggtt tcctcggtgt accaaggcga agagaaagcg gaaacttctc cccagcctgt 2933521 gacacctgat gtatcaatgg cttccacgat cagaaattta cgctcttgaa gcgtttcgat 2933581 actgttttta aacggtttct ttaagttcat gctcaaatgg taaagcgtga ttttttctat 2933641 ttcgatcata gcagttctcc tttacgcgca tccttcagct gatttcgcaa gagcttatta 2933701 gacgcattgc gcggcaggcg gtcaagcaca aagaattttg ccggaatttt atacttcgcc 2933761 aagcgttctt tgcagtagtc agtcaattct cctgcgctca caggcttgtg aaggacaaga 2933821 taggcgtgag gcactttccc ccattttttg tcctcagccc ctgaaacccc ggcttcggcc 2933881 acagcggggt gtgaaagcag cactgactcc acttcggccg gataaatgtt ttctccgccg 2933941 gatatgatca gatctgaacg tctgtctaat acatataaaa agccttcatt gtccaaataa 2934001 ccaagatcac ctgttttcag ccagccattt tgaaaggagg cttcgtttgc gctctcccgg 2934061 ttaaaatagc ttttcatgac attcgggcct ttgaccatga tttcaccgtg ttcatacggt 2934121 tcacatacct gtccgtcccg ctctattttg atttcacacg aaaacagcgg tttccccgca 2934181 gatccgagct tttccatgct gaattccggc gacagggtaa caatttgcga gcatgtttct 2934241 gtcattccat atgactgaaa gacagggaat cctttctcac ggcattcctc aagcaatggc 2934301 agcggtgcag gaccgccgcc gagaagaatg catctgatgg attcagggca gcggtttgtt 2934361 tcttccaaaa gactggccag catagtctgc accgcagata tcattgtcac ttcatgcctg 2934421 ttgatagaat gcagcacatc gcttacggaa aaacgctggt gaagcacgac agtcattcca 2934481 tagatcacag atttaaataa tgcggacaat ccgctgatat gaaagagcgg caatgcgata 2934541 agccagcggt cttgttctgt tatacccaaa ttaagagcgg acgacaccgc actgaaataa 2934601 tggtttccga acgtttgctg aactcccttg ggctttcctg tcgtacccga cgtatacatc 2934661 agcgttgccg ttgcatccat ttgcatataa gcctcgatct caatttcctc tgctgcttct 2934721 ttcatcagtt catccacatc aatcgtttga acgatgtgtt catattcttt cttctcaaag 2934781 cttgaatctg tcaataaaaa gccggatccc gaatcctcca gctgaaacag cctttcatgt 2934841 gttgacagct tcgtattcaa aagcaccgcc ttaacaccaa gcaaaaaaca agcgtgaaca 2934901 gcgtatacca tttctgcacg gttttggagc aaaatagctg cagtatcccc tttccgaacc 2934961 gaatgagcgg caagctgttc cgccattcgt ttagacgcgg caaacaattc tgcaaatgtc 2935021 acggtttggt cttcatagat gagagcgatt ctctcaggtg tcagctgtgc ccgctgcatg 2935081 agccagttgg gctgttctgt cagcatgtca tcatctccga ggtaaaatgt ctgtattgaa 2935141 aagaaaacag cttggaccgc aaagtctcaa gctgttggtt tactagatat tgctgatcac 2935201 ggaaaacgag ggaactgtcc gaaatcaggt ttgcgttttt ccttaaagga atcacggcct 2935261 tcttttgctt catctgttgt gtagtaaaga agggtagcat cccctgcaaa ctgctgaatt 2935321 ccagcaagtc cgtctgtgtc cgcgttaaac gcagctttaa gaaagcgcag tgcggtcggg 2935381 cttttttcaa gcatttcttc acaccattta atcgtttctt cttcaagctg ttccaaagga 2935441 acgactgtgt tgacaagacc catgtccagt gcttcctgtg cgttgtactg acggcatagg 2935501 taccagattt cacgtgcttt tttatgtcct acaattcgag ccaggtagcc agaaccgtaa 2935561 cctgcatcga agcttcccac tttagggcct gtttgtccaa aaattgcgtt gtccgcagca 2935621 attgtcaagt cacatacgat gtgaagcaca tggcctccgc cgatcgcata tccggacacc 2935681 atcgcaacaa ccggtttcgg gatgacgcgg attaaacgct gaagatccaa tacgttaaga 2935741 cgagggatct ggtcgtctcc tacatatcca ccgtggccgc gcactttttg gtctccgcca 2935801 gaacaaaatg ctttgtcccc tgcaccggca agcacgataa ccccaacgtt ttggtcgtct 2935861 cttgcgtcag caaacgcatc aatcatttca gcaaccgttt taggggtaaa cgcattatgt 2935921 acctcaggtc ggttgattgt tatttttgca atgccattat acgtttcata caatatctca 2935981 tcgtatgtcc gttttgtttt ccattcagcc atatgatgac ctccttttat tctctatgtg 2936041 aatgagtcag atgcttgtca aaaactcact cactatttta ccaaacaatc gcggctgctc 2936101 cacatggacc gtatgtcctg cttttggaac aatctctatt ctactagaag gaagcatctt 2936161 atgcacctct tgattgatgg cgcaaaattt ttcgtcccac tccccgcaga tcagaagcac 2936221 aggaacatct atttcctcta cacggctcca caaggaaggc tgtgaaccgg tgcccatgcc 2936281 ggttaaactg ttcgcaagcc caatcttatt gttccgcaga cggcccgatc gtatcctgta 2936341 ccgaatatct tcagccagcc tctgctgaga tgaaaacaaa gggatattct cccaatacgc 2936401 aacaaacgct tcgagcccgt ctcgtaaaat aaaatcagca agcttccggt cccgcatgat 2936461 tcgttcccgc cgttccccaa gtgttttgag ccccggcgtc gtgctttcaa gcacaagtgc 2936521 cgatacccgc tcgggatatg tcatcgcaaa agagtaagca agccttcctc ccatagaata 2936581 cccaatcaat ttcactttgt gaagttttaa ttgatcaaaa atctcggcaa ggtcagaaac 2936641 ttgccgggtt gtgctgtatc ttttcccatt cagcggggca tcggtttccc catgccctaa 2936701 acaatcaatt ttgatcaaac gggaatcagg cagcatttca tcaagaaaag tccatgattg 2936761 tttgctgccg gtaaacccat gcagacagac gacggcttcg gaagcattcg gtccctcgtc 2936821 tgccactgca tatcggacac catctgatac cgttatgttt acagttccca ttgttttttc 2936881 acttcccgca cagcctcatt cagcatatcg cgatgaagct ggactcttga ttggcgatcc 2936941 gttttgattt caatcaaatg gagtccgggc ttgtctgcct gcggcgcgta agctgttttg 2937001 aattcatccc aagaagccgg gcatgaatac gttccgccgt aaagtgcagc cgcatgcttg 2937061 aaatcgagcc ctgtcggtgt gccgaacaaa tcttcaaagt gtgtcttctc agaagcctgc 2937121 ggcaaaaagg agaaaatccc tcctccgtca ttattgacaa gaatcacagt aagaggaata 2937181 cccagctttt tggccgccag caggccgttt aaatcatgat aaaaagataa atctccaatc 2937241 acaagggtaa caggcgcttt tgttccttca cataccccca tggcagagga gacgacaccg 2937301 tctatcccgt ttgctccccg gtttgaataa atccggaaag ggcggtcctg cttttcaaaa 2937361 aacgtatcaa catccctgat cggcatgctg tttcccacaa acagcgagct gttttcaggc 2937421 acaagatgct gaaggattcg atagagattg ccttcaaacg aaacatcttc actgctgatt 2937481 gtttgcagat gctcgcggaa ccgcccattg acaaactgcc acttttccag ccactctgag 2937541 gatctggtgg cagcagtaag gcctgccatg atctcctcag caaaaacaga cgcattacaa 2937601 tgaatcatat gcgcgcttgc ctgtgtcggg tctctccacc ctccatcctc gtcaatcacg 2937661 atttgctgaa tcgtcggatc atccttaagc cataagaaaa ccggttttga aacaggcatc 2937721 ggtccaaacc gaatgacaac atcaggacgg agtttccgct tcagctcatc atcttttaaa 2937781 aacgaatcat acgcatcaat aacagtgctt ttatcatgaa caccattccg cagattagac 2937841 agcggatctg ctaaaattgg atactgaagc gcttttgaca gcgcaataat gttttccttg 2937901 tccgcatcac tatggagctc tccgcagacg atcattcctt tttcagcctc tgcgagcatc 2937961 tcagccacat cagacaggga ctctcggtca acagactgcg tacccgtttt cacagacaca 2938021 tgacggcctg ttctcattct tccaaacggc tcatctgaaa gatccggcat cagcggttcg 2938081 cgcagcggca cattcacatg gacaggcccc atcgggcgct tttgtgcttc tccggcagcg 2938141 cggcttgcca gcgttcggat gtatctcagc atttgcggag actcttcagg aagagcagag 2938201 tctgtgaaaa acttaacaaa gttaccgaat aagaagtgct gattaatagc ctgcggtgcg 2938261 cctacttcgc gcagctcatg aggccgatca gcagttaaca caataatagg cacccttgaa 2938321 taatgggctt caaccacagc cggataaaag ttggccgcgg ctgttccaga tgtacagatc 2938381 aatagtacgg gacgctgctt cgcttttgcc aaacctaatg caaaaaatcc ggcagacctt 2938441 tcatcaattt ggacatggac gctgatatcg ggatgcgcag cacaaagaac agccagcggt 2938501 gtagatcttg agcccggaca aacgacggcg tccgtaattc cggaaagggc gaattcatca 2938561 ataaaacttc cgatgtaatg agtaatcggg ttgactgtca acgcctctca cctcctaatg 2938621 cagagatcat cggcttcaat ttaatctgtg tttcttcata ttccgagatt ggttccgagt 2938681 cttccacaat accgcacccg gcaaacagcc ttgctgtgct tccttcgatg agccctgaac 2938741 gaatggcgac cgcgaattcc ccgttatcct ggctgtcaat ccagccgata ggggccgcat 2938801 accagccgcg ggacatcggt tcaatctccc tgatcacgtc aacagctttt tcctgaggtg 2938861 atcccccaag cgcgggagtg gggtgcagct tctcaattaa gtcaaaaatc gaagcagact 2938921 cgcgcagctg tccgacaatc ggcgtaaaca ggtgctgaac gctttttgtt ttgtacaaaa 2938981 caggtccatc aggcttttca acctctgaac agcttgatac aaaagcatta tgaatcatac 2939041 ctaccacaat atcatgctca agcaggtttt tctcatcgtt taataattca aggcctatcc 2939101 ggcggtcgtc ttcttcattc acgcctcgtt taatggagcc tgccagacag gaagacatga 2939161 cagtgccgcc gtctcttttg atcagtcttt ccggagacgc gccgacaaag gttttgcctt 2939221 cttgttcaat tgcaaaaaca tagcttgtct gctgatcgtc cagaagcgtt ttaagcaccg 2939281 gttcaatttg gattggaccg tcaaacgtga gcagcagctc tcgggcaaga acaaccttat 2939341 catattgttt ctctttaatt tggcttgtgg ccgtttcgat tgctttcagc caatcatcct 2939401 tatccagctc ttcggctgct gcaatcacag cctgatcttc ttgcttgaaa tcgggaacca 2939461 taaattccgc cgcaaaagct tttaagcctt ctaaaacagc ttctgcgtct tctcctccgc 2939521 ttacccatct gttaactgtt aagaacgggc cttcagcagt catcgtcagc ataagcgcag 2939581 gcacaaagaa atccccttcc gagaaatggt cccattgtga acctctttct tcgcaagggt 2939641 caaaagaaaa tcctccgaat aacacaggtc ccactgcaga atgctgcagc ttttcttctt 2939701 cataaatatg aaaagccgtc tttttaaagc gctcccattg ttcaaaaacc tcacgatacc 2939761 gctcgctgtt tttttgattt gtctggaaaa ccgcttcttt gccaagaccg actattgtca 2939821 attcactttc aggatctgac caaaaaaatc gattgcctgt atattttttt gctccgtaat 2939881 tgaaaaatga tagagggtca agagactcga tttgtctcga atagcttatt aagacagcat 2939941 ggttgacttc tttggcttta tgtaatgcat gtagaacttc ctttcggaac gtacgctgca 2940001 ccgttgtcac catgagacat tcctccataa tccttaaaat gcttttaata ccatacacct 2940061 gtgtctcctt tgtgtcaaac acagatcatg cagtccaaat ggcctgcctt acctattata 2940121 aacctaattt cagaaatgaa aaagaaacaa agcttaaatt tctttctcca ctgatagcaa 2940181 aggttgtatc cgcttaccat aaaaggaaaa cctcctatat tcctccaccc gccatttatg 2940241 aaagttctca ggcgatctgt tcatactaaa ggtatgcatc acagagaaac gaggcgatca 2940301 cattgcttac gaaagaacag cttcagcatt taaaaaatga actggaacaa acgaaaaaag 2940361 atatcttaaa ccgtttcaaa gacaatgatc attttcagct taactcagcc tttccttatg 2940421 attcgtgggg tgagctttcg gcatacgaca accatcccgg cgatcaggcg acagaacttt 2940481 acgagcgtga gaaagacatc gctctagact tgcatgagag agagcacctt cgggacattg 2940541 agcattcatt gaaggcgata gaaaacggta cgtatggcat ttgtgaagtc agcggaaagg 2940601 aaatcccttt cgaacgactt gaagcgcttc cgactgccac aaccctcgcg gagtattcgt 2940661 cacaggacgt ggtttccaaa gaccgtccga ttgaagaaga aacaccattc gggcaatttg 2940721 aatttgatga tgatgaagaa atcagagcgc catatgacag tgaggattcc tatcaggatg 2940781 tcgaaaaata tgggaactca caaacgccgc aggatatgga aaaccctccg ctcagctatg 2940841 atgatatgac gatgaatgcc gaagagaata tcggcaatac ggagtcttac gaaaatttca 2940901 tcgctacaga tatcactggg aaagaaatta ccgtttatca aagcagagcc catgagcgct 2940961 atgaagaaga acttgacgaa gagggaatca tgaccacatt cggcgatctc cacgctgatt 2941021 gaacccccaa ttattggggg ttcttttccg ttttcagcat atcgtaaatc agcttcagat 2941081 aatccttttg caggccgatg tcataccgct cgccctctag caatttcccg tatacggtac 2941141 atgccccgag cgaagctttt atcgcatccg ttacctgcac ttctcctccg ctatcagctt 2941201 ctaatgcctc cagctcatta aaaatatccg gtgtgaaaat ataacgccct gctgcggcaa 2941261 aatgagacgg agggttttgt ttaggctttt ccacaatatc ctgtatgcga taaagccctt 2941321 tttcaacagg ctcccctttt atcaccccgt aatgatgtaa atcctccgtt tttgtttctt 2941381 ttaagccgat cacactggac tgatatttcg tatacgcttc aatcagctgc cccaaagccg 2941441 gctgattggc ggaaaaaatc agatcatctg gcaaaacgac ggcaaaaggc tctcctcctg 2941501 caaattgctt tccgaaagaa atggcgtcgc caagaccctt tgcataaggc tgccgcacat 2941561 agtgaatccg tatatccgga atgggatgct ctctaagtaa atgcagttta ttcttagagg 2941621 ccaaaaaagc ctcaagtgcc aaagaggaat caaaatagtc gacaatcaga tttttatggc 2941681 tcgatacaac catcaaaatg tcctcaatgc ctgactcctt taattcttca acaagataat 2941741 gaatcacagg cttagatcct accggaaaca tttctttcgg aatcaccttc gtcaccggca 2941801 gatttctcgt gccgaatccg cctgcaggaa tgatcgcttt ttttatcatg gtattttccc 2941861 ctcagctcat gtttattaca tgatattcca agagcgcatc ccgatgtttg tacatctgaa 2941921 attaggcgga agcaactggg cagaaagcgg aatcacgaac cagccctttt ttaataggat 2941981 attgatatat gaccagtaat cttgtaaagg agctcaggtg atgaaaattt gtgtggttgg 2942041 cgccgggtat gtcggtttaa ccctatcagc ggcactggca tccatcggac atgacatgat 2942101 atgcacagac aaagacgtca aaaaaatcgg gcagctgaaa aaaggagtca ttccctttta 2942161 cgagcctggg ctttcagatg caatacttcg ttgcggcaat ctctcgtttt cttctgaagt 2942221 gaaatcgagc atggaggaat gtcccgttat ttttatcgca gtcggaactc cgccgcgttc 2942281 ggacggatca gctgatacga aagccctgca gtccgtcatc ggtgatttaa gcgaggcgat 2942341 ccgatcgtat aaaaccatta ttacgaaaag cactgttccg cccgggacaa atgaaaacat 2942401 agcaaaacag ctgattgcct ccggagtgtc taaaaacctc tttaatatcg tatccaatcc 2942461 ggagtttctg cgggaaggca atgccttata tgacatgctg catcctgaca aaacagtcat 2942521 cggtgttcag gaagaagatc acgtatcggc agccatcgtc aaatccattt acaaacacat 2942581 tgatacccct tttatcgtta caagcttagc gggagcagag ctgatcaaat atgccaacaa 2942641 tttcttttta gcggccaaaa tttcgttcat taacgaaatg gcccgcatat gtgaagccta 2942701 tcaatcagat atctcagata tttcccgcgc tatcggtcta gacccaagga tcgggaagca 2942761 ctttttgcag gcaggcatcg gatacggagg ctcttgtttt ccaaaggatc tgcaggcgct 2942821 gcaatttgct gcccaggaaa aaaacacgga gaccttcctg ctccgggccg tgcagcacat 2942881 taatgacacc cagcttggcc tgtatatcaa aaaaatacag tcattcttcg aaacacttca 2942941 aggcaagaaa gcggctgtac tcggcatttc cttcaaaccg aatactgatg acatccggaa 2943001 ttctcaggct gtcagactga tggaaaggct ggcggagctg ggatgtgatg ttcatgcata 2943061 tgatcctgaa gctgtacttc cagaacattt gcggcaacat gtaactcagc attctcaagc 2943121 ttttgatgcg atcgaagaga gtgacttttt atttttggcg acagaatggt ctgagttttt 2943181 agcgtttgat tggaaaaagg ctgcagatat catgaaaggg cgtcttgtga ttgacggacg 2943241 caacgtacta aaaaaagaac tgatcgaggc ttgcggcctg atctgtacgg gagttggccg 2943301 tccatgaaaa tactcgtcac aggagcagcg ggctttatcg gctcccacct ctgcgaagaa 2943361 ttactaaaag ataagaaaca taacgttatc ggaatcgatg actttatcgg tcctactcca 2943421 ttttccttga aattaaaaaa ccttaaaaac ctgctgccgg aaaagcgatt tacgttcata 2943481 aaggaaaatc tgctgacagc cgatcttgct tccttactgg aaggagtgga cgtcatcttt 2943541 catttggcgg ccataccggg tgtccgctca agctggggca atcattttca cccatatgcc 2943601 gcacataata tccaagcgct ccaaaggctc ctcgaggcgt gccgggaaca ttctattcaa 2943661 acgttcgtct ttgcatccac ctcttccgtc tatggcgaaa aacaaggaaa agtcagcgaa 2943721 aacacgtcgc tttctccttt atctccgtac ggggtaacaa agcttacggg agaaaagctt 2943781 tgccatgtgt ataaacagag ctttggcatt ccaattgtga ttctccgttt ttttaccgta 2943841 tacgggccaa gacagcggcc ggatatggct tttcaccggc tcattaagca gcaccttcag 2943901 caaaagccgc ttaccatctt cggtgatggg cagcagtcaa gagatttcac ttatatcagc 2943961 gactgtgtca aaggcatcac cgctgttctt gggaaacccc accttattgg tgaaacagta 2944021 aatatcggcg gcgcagagcg tgcctcagtc ttaaaagttg tctccctcat tgaggatatt 2944081 tccgggagaa aagcaacact gcacttttcg gacaaaatag caggggaacc gagcaacacg 2944141 tgggcggata tttcaaaagc aaaacagctc ttgcattatg atcccgccac atccttaaag 2944201 gatggcttga ccaacgaaat cgcctattta tcgtcgctgt atcaggggga ataaaaatga 2944261 agcttgcctt tatctgtaca gaaaagctgc cggcgcccgc agtacgcggc ggcgctattc 2944321 aaatgatgat tgacggtgtc acgccctatt tcagcagcag gtacgacctg accatttttt 2944381 caatagaaga tccatcgctc ccaaaaagag aaacaaaaga cggcgtacat tatatccatc 2944441 tgccaaaaga acattaccgc gaggcggtag ccgaagagct gcgagcctct tcctttgacc 2944501 tcattcatgt gttcaacagg cctttaaatg tctctttata taaaaaagcc tcaccaaaca 2944561 gcaagatcgt tctgagcctg cataacgaaa tgttttctga aaaaaagatg accttcgcgc 2944621 aaggaaaaga agtactcgac aatgtctcca tgatcacaac agtgagcgaa tttattaaac 2944681 aaaccgtcat tgaacgtttc cctgaagccg aggacatcac aaaagttgtg tattccggcg 2944741 ttgatttaaa ctcttatccg cccgtctgga cgatgaaagg ctcggctgtc agaaaaacat 2944801 accggaaaaa atacggtatt gaagataaaa aagttatttt attcgccggc cgcttaagcc 2944861 cgacaaaagg gcctcacctt ctcattcaca gcatgagacg gattttgcag cagcaccctg 2944921 atgctgtact ggtcatagca ggcgggaagt ggttcagcga tgacagcgaa aaccaatatg 2944981 tcacctatct gcgcacgctg gcgctgccat acagagacca cataatcttt acaaaattca 2945041 ttcccgcaga cgatatccca aacctttttc tgatggcaga tgtatttgtg tgcagctctc 2945101 agtggaacga acccctcgcc cgtgtgaatt atgaagcaat ggcggccggc acgcccttaa 2945161 ttaccacaaa ccggggcgga aacggtgaag tcgtaaaaca cgaagtcacc ggccttgtca 2945221 tcgatagcta caacaaacct tcttcatttg caaaagcaat tgacagagcc tttacagatc 2945281 aagaattaat gaacaaaatg acaaaaaacg cccgaaagca tgtagaagct ttatttacct 2945341 ttacccatgc tgccaaaagg ctcaatactg tttaccaatc cgttctgacc ccgaaaaaca 2945401 aacaatttcc gccgcctttt ctgacgcaaa attttgattt atcatctatc aatcagcttt 2945461 ttgtgaaagc aaaaacataa aacctacagc tcgtgttgca aaacgggctg ttttttcgct 2945521 acagagaact taaaaaaagg cataaatgtg actttatgcc ttgcgcttta cagtttgaga 2945581 aaaccatgga gctggtttag attcacttgg aagaatgatg atttccactt tagcttcttc 2945641 cgctaagtct ggttcttcat cttcatcctc ttcttcatat gggggcgctg agcgtttcga 2945701 atcacgctcc tcctcaggct ccagagtggt ttcgaatttt gtttcttctt catcatcgac 2945761 gattttgcga tctgtttcct tttccttcgt ttctttttga tattctttcg gtgcattgat 2945821 gtgagggagc tctcgaatgc tgcccacatc taaatgcttc tcctcttctt ccttctcagc 2945881 tgagattgag tcatgagcct gccatcccat cggtccaggc ggtgtaaata cgaattggtc 2945941 gagatccagt ttagaaatag aggctttttg tctcgatgac ctcatgtcaa ttcgcctccc 2946001 gatacgcttt tatcttttta tacagttccg gcagtttatc caaaaacgaa tctttagatt 2946061 cttcaacaga aatcatgttt tgcagcgccc agttatactt ctcatctgac cacgttttct 2946121 tttgcttcaa ataatatttg tgcccgattg cacagaacaa atgcggaaac gcgagatcaa 2946181 tccaaagtac ctcgtactgt ttttctgtga gcggatacac tgcgtcgtag gccgcaagca 2946241 gtgcaaccat gaaatcagta tcccatacag aaagcttaac catcacttta ttcagcagaa 2946301 tacgaaggtc tcttgacggc aaatcgtagg taatcgagtg aagctccttt aaaaaaggct 2946361 ccccttcgat ctcagtcaaa cgtgccaatg taaaatcctg aaaacagaat ccgccatgct 2946421 cgagtgtctc ttttgtccag gtttcgtatt ctgagtcatc aagcgctctg agagcttctt 2946481 ttcctcttgc cagcatttta tcagcatgtt ttaagaaagt ttgcgaaaat acgtcatcag 2946541 gataggatgc tgcgatctgc atattccctt caagttcctg cagcttccaa cggtacaatt 2946601 tgtgccattt tcccagcctg cttctcttct tgctttcatc tgtgcaaaca tatccttttg 2946661 aggcatgatg aaaatggccg gcaaatgaca tgactttttt catttgctct gcatcatagt 2946721 aaatcatttc ttttcctgtc actttgtcat ataaactgta agaaacctga tccgtgccca 2946781 agcagctacc gccatttttt gtttgatgaa tcggcgctat cggcagccct ttctcttgta 2946841 aatgggcgtg tgcctgagtg ataaaaagca tccgctccgg tttcatttgc gcttctttta 2946901 gcagctttgg gccatgatca gtttcgactt cccagatttt gcgcccgctt ttgttcgatt 2946961 tcagcgccac atggtcgata tgaaacggat aataactgag aatttcggac acaatctgtt 2947021 cttcatgctc tttttggtac actctgttca ccccttctat ctgttctttt catagacgct 2947081 gagcagattt tcagccaccc tctgccagcc aaaattgctt tctgcctcac ggcggctgta 2947141 tttcccaagc cgttcccgct tttccgagct gctcagcaaa tcattgatac gttcggcata 2947201 ttgtttagga ttttcaaagt catgaatgat gtagccgttt ttcccttcct ctatgacctc 2947261 tggattgcct ccccgattgc ttgtaataat aggaagtccc gcagccatcg cttcataatg 2947321 cacccttgct aaaggctcct gccattgcga agagcataca aatacatctg acatggtata 2947381 aaggcgcgga atgtcctttg gcttcacaaa ttgaataaat gtgacatgat ccttttgcat 2947441 cgcaccaagg gtatgaagat gtttgacata gttatttaat tcattatctc cgaaccattt 2947501 tgacccgata aacaccatca tgacatcggg gtgctcctca atgatgtccg gcaaagcctg 2947561 caataatatg tgcgggcctt tgactttgct aagccggccg acaaacaaga cgattttttt 2947621 gccgtgaagc cccagctcgc ttcgcatctc ttcgcgagct cgctgccctt cattcgtcca 2947681 gcgagggtgg tacgttttta aatccacacc agaatacacc gtttttgttt ttgatcgtgc 2947741 tgacggaaaa cggcttgtga tcgtctgtcc gatataatcg ctgaccgtaa caatctgcgc 2947801 tacggagtcg atgcaaatct cgccttccgc ctggctgatt ttatcgtaag cgaacatttc 2947861 attgtgaacg cttaaaataa aaacagcatc cggcgcctgt ttcttcaatt tcggaaccca 2947921 gcttgggcga ttacaaacat gcacaagatc aaaacggctc tttttcagct ctgctccaac 2947981 ggcttcttca taacggtctt catccaaatg cacataatgg acaccgtcta ccttctctct 2948041 atcagcgaga ttcggatctt taatagaaaa cacagtcacc tcatgttttt ttgcaattaa 2948101 aggggcaacc gcttcgaggt agatttgaat ggcgcctcct cgaaccgatg ggacaggaag 2948161 cttctctgtg gcgatcagtg ctattttcat acatagcctc cattcctgca tgatttttaa 2948221 ctagttagaa tcatgatacg gctgaacaac caacttgtgc ggaatgggac tgccctaaaa 2948281 acaaaacggg taaacaacca gattcatcta ttaaatatag tcaaataact caatcatttt 2948341 ttccttttga ttcataaggt aggagtaaaa caggtaagga tgtgtccttt aatggcagaa 2948401 aaccatgaag tcattgagga ggggaattca tcagagcttc ctttatcagc agaagatgca 2948461 aaaaaattaa cggagctggc tgaaaatgtg cttcaaggat gggatgtgca ggctgaaaaa 2948521 atagacgtca ttcagggaaa ccagatggcg cttgtctgga aggtccacac agactccggc 2948581 gcggtttgtc taaaacgaat acacaggcca gaaaagaaag cgttgttttc cattttcgcg 2948641 caggactatt tagcaaaaaa aggcatgaat gttcctggca tactcccaaa caaaaaaggc 2948701 agcctatatt ctaagcacgg ctcatttcta tttgtcgtat atgactggat cgaaggaaga 2948761 ccgtttgagc tgactgtaaa gcaggacttg gagtttatca tgaaaggcct tgctgatttt 2948821 catacagctt ccgtcggata tcagccgcca aatggcgttc ccatatttac caaattaggt 2948881 cgctggccga atcactacac gaaacgatgc aaacagatgg aaacgtggaa gctgatggcg 2948941 gaggcggaaa aagaagatcc tttctcacag ctttatcttc aggagataga tggctttatt 2949001 gaagacgggc tgcgcatcaa agaccggctt ttgcaatcga cctatgttcc atggactgaa 2949061 cagctgaaaa aaagccctaa cctttgccac caggattacg gaaccgggaa tacactctta 2949121 ggagaaaatg aacagatttg ggtcatcgac ttagataccg tatcatttga tctgcctatt 2949181 cgcgatttgc gcaaaatgat tattccgctt ttggatacga cgggtgtttg ggatgacgaa 2949241 acatttaatg tcatgctgaa cgcatacgaa tccagagccc cattaactga agaacaaaaa 2949301 caagtcatgt ttattgatat gctgtttcct tacgagcttt acgatgtcat tcgcgaaaaa 2949361 tacgtccgca agtctgcttt accgaaggaa gaattagaat cagcttttga atatgaacgc 2949421 attaaagcaa acgcattgcg gcagcttatt taagaccatc atttcccccg catatcgggg 2949481 gtttgatatt tataagataa agggtaatta aatacatgcg gaggttgcaa atatgaaaaa 2949541 gattgtcggc gctttagccg tttttgtgat tacatatgcg ctgttttcag ccgcaggcta 2949601 cctgtttcct gtggaccaag aatggtacaa ttcattgaaa aaaccggact ggacgccaag 2949661 cggaactgcg atcggcatca tttgggccat cctgtttgcc ctgatctccc tttcagcagc 2949721 cattgtatat gctgcgtttt catttaaagg tgcgaaaagc ttttggttta cacttttgat 2949781 aaattacgtg ctcaatcaag ccttcagcta tttccagttt acgcaaaaaa atctgctggc 2949841 tgcatcgctt gactgcctgc ttgtcgccat cacagcaatc gtattactga tcattgccaa 2949901 aaaatacagc agagccgcaa gctatcttct tttgccttat tttttatgga gtgcatttgc 2949961 gacgttctta tcctttacaa tcaattcaat gaatctgtga acaaaaaaag ccgcttatac 2950021 agcggctttt tcacatcatc ggcttgatgc cccaaatgtc cttcgcatat tcccggatcg 2950081 tgcggtcgct ggagaaatat ccagaatgag caatgtttac aatcgaatgc tcagaccatt 2950141 tccttcgctc tcgataatca gcttgaattc gctcctgtgc atctgcatat gagctgaaat 2950201 ccttcagcac aaaatactca tcattatgcg gaagcagcga gtcaaagatc gattcaaatt 2950261 catctgcctc tccttcaaaa aaaccattga tcaactgatc cgctacctgc ctgattctcc 2950321 tgtcatgctg ataatattcc ctcgacctat agccgccgtt ttcctgatac gatagaacct 2950381 catccgcctt taagccgaac gtgtaaatac agtcagggcc cacccgctca aggatctcga 2950441 tatttgcgcc gtcatgcgtg ccgatcgtca aagccccgtt catcataaac ttcatattcc 2950501 ctgtaccaga cgcttccttg cttgcggttg aaatttgctc acttacgtct gatgccggaa 2950561 aaattcgctc agccatagaa actctataat tttctaaaaa aacaactttg atcagctgtt 2950621 tgaccgccgg atcataattg actttttctg cgacagaatg gatcagctta atgattttct 2950681 tggcataata atagcttggt gaagcctttg ccccgaaaat aaaggtttgc gggtagattg 2950741 aaaaccccga atcctccttg aggcggttat acaaatacat aatgtgaaga acattcagca 2950801 gctgccgttt atatgcatga agccgtttca cctgtacgtc gaatatgctc tcagggttca 2950861 caaccacccc ggccgtgcaa aaaatcaaat cggcaagctc ttgttttttc ttgcttttgt 2950921 tgttttgaaa ctgttcaata aatgcaggat cagtggcgta cggttctaaa cggatcagtg 2950981 attccggctg cttgacccat tcatcgccga tcgcctctgt aatgatggca gacaagcctg 2951041 gattcgcttt taacagccag cgcctgtggg caattccatt cgtcttattg ttaaaacgat 2951101 tcggaaacag caagtgaaag tcgcgcatct ccctttcctt taatatatcg gaatgtattt 2951161 ttgcaacgcc atttacactg tagctgccta ctatggccag atgagccatt ttgacaacac 2951221 catgcgctgt aatcgccatg ttctctatcc ttttccagtc tccaggatac ttttcccaaa 2951281 ctgcacggca aaacctctca ttgatctctt caataatcat gtacattcgc gggagcagcg 2951341 gcttaaacaa atgaatcggc catttctcga gcgcttctga caatgttgta tgatttgtat 2951401 aagaaatcgt atgtacagtg atatgccaag cttcttccca gctcatgttc tcttcatcga 2951461 gcaaaatccg cattagctca ggcaccgcaa gcgcagggtg agtgtcatta atatgaatgc 2951521 tcactttttt atgcaggccg gataaagatt tatgtgtttt acggtaattg ttcacaatgc 2951581 tttttaagct tgcgcatact aaaaaatact gctgcttcag ccgtaaaatt ttcccctcat 2951641 catgggtgtc atcgggatat aagaattcag aaaccgcttc tgtttctcgc ttataagaca 2951701 aaatattacc gccgtgataa tgggcatagg gctcggcgtt ccaaagcctt aacgtgttga 2951761 cagtgcccgt ttcatagccg atgatcggga tatcataagg aacagcggta acaattgtcg 2951821 cttgttcatg gcgaaaatgc aggcgcccgc ttttttctgt catatggact tcgccccaaa 2951881 acggcacgtc cactgcttga tccgcattcc ttacttccca tacgttcccg tttttcagcc 2951941 attgctcagg cagctccacc tgatgtccgt ctacaatttt ttgctcaaac aaaccatgct 2952001 tataacgtat gcccatgccg tgcccaggca ggttcaacga agcaagcgaa tctaaaaagc 2952061 aagcggccaa gcgcccaagt ccgccattgc cgagacctgc atcgttctct atctgaagga 2952121 tctcctctaa attgatgccg atttccttta aaccagcttc tacaacatca cgaacaccaa 2952181 gattcattaa gttttgctca aggagctgac cgagcagaaa ttcgattgat aaataatatg 2952241 tctgcttccc ggaatttgat ctgctttttt cattcgtttc gatccaatca gcgctgatat 2952301 actctctgac catattgccc aacgttttat attgatccag cttggcagaa tctttaaagc 2952361 tttttccgca cgtcatttcc agacgcttta aaaataagtc tgcaaagcgt tctttactcg 2952421 agaacatccc gtccactcct tgtcacctgc tcgaaaatac gctgatactc tttagccgac 2952481 ttcccccagc tgtaatctgc attcatagcg gtcttcacga tgctcttcca tacatcctgt 2952541 tggcaataaa acgacagcgc cctttctatc gtaaatttca gatcatgcgc attaaaggcg 2952601 gaaaacgtaa agccattgcc cgttccctct tcctcctgat aggcacggac agtgtcgtaa 2952661 agaccgcccg tttccctgac aatcggaatg gcgccatatt gaagagcaat gagctgcccc 2952721 aaaccgcacg gctcaaattt cgacggcatc aaaaacatat cagagcccgc ataaatttga 2952781 tgggctagcg gctcatcaaa cccgatataa gcccggcact tctcatgaaa agcaaattct 2952841 gcataccgga aataatcttc aaattcacgt tctcctgtgc ctagcacaac cagctgtatg 2952901 tcttgctcct caagaagttc gtgcataatt ctgcggacaa gatcaagccc cttttgttta 2952961 gtgagccttg tcaccatact gatcagcgga atatcgtttt tctctggaag ccccatccgc 2953021 tgctgaagct tcgttttgtt ttccagcttg catgcaagat cccctgaatc gtattgcgcc 2953081 tctatataag ggtcgctttt cggctgatag aacgtatcat caatgccatt taatatgccg 2953141 gttacatcat cttccctata ttgcaaaacc tgttccaact gctcaccata atacggcgtc 2953201 atgatttcat ttctgtaagt ggggctcaca gttgtcacat gatcagccgc aatgatgccc 2953261 gctttcataa aattaacaaa tccgttgcat tctaaccttt cataatgaaa atgatccatc 2953321 tcaagaccca gcaagtcatg tgtgacatca ggagggaata tgccttgaaa ctgcaggttg 2953381 tggatcgtga gcacgctttt catccgttca taaaaaggat gttttctgta ctcctctttc 2953441 agcaaataat tgaccatcgc tgtatgccaa tcgtgagtat gaacaatatc ggcttgaaca 2953501 ttcacaactt tggcagcctc cagcacagct cttgaaaaaa aggcaaaccg ctcaccgtca 2953561 tcataatgcc cgtacaacga atccctgttg aaatagtact cattgtcgat gaagtaataa 2953621 ttcacatcat tctctgccat atgttcaatt ccgcaatatt gctgccgcca gccgacagct 2953681 acggtacact cagcctgttt tttcatacgc tttttccacg gttcaggtat ttggctgtac 2953741 ttcggcagca tcacagctac ctcattgcct aatcgcgcaa gcgcctttgg cagagcacct 2953801 gctacatcgg caagacctcc tgatttcaca aatggggtgc attctgacac agcaaataat 2953861 atcttcaaga attcatcagc tctccttgca ccaaaccttt tcttaataca agcggctgct 2953921 cagctgttcc tgcagcttcc gtcgccttgc cgattttaac atccttatcc gaaatgacct 2953981 gctcaagaag acaatcctct ccaatctgcg ttttttgcat aataatgcag tttttcagct 2954041 tcgtaccctt tccgacatgg accgccctga acaaaatgca gttttcaacc tctccttcaa 2954101 gcacacagcc gtttgccacc aaagaatttt tgacagtgct gtgctttccg tatttcgtag 2954161 gcggctcatc cttcactttt gtatagatcg gctgctgcgg caaaaacacc tgctgccaaa 2954221 aacgaggctg aatgagctcc atactgtggg tataatattt ttccaccgaa tcaatgacag 2954281 cggcataacc tgaatattca taagggcaaa tggtcagggc ggaagattcc ttttcaacag 2954341 cctcctgaat ggttttatag cctttttcgc tatgtccgta gatcagatcc tttaaaagcg 2954401 ttgttgacat gatatagatt tgcagcgact ggccgtcctg aaatacctcg gtgacgtcgc 2954461 agccaacctc ctgatggcgt ttcagcacat attgaaattg aatgttgcat acggtatggc 2954521 tgttggagat tacagcatat tgctgagtgc ttctgtggaa gtaatctaga tggtccgaaa 2954581 actggcgaaa ggaaccgaat tcatcgtatt cgtgatgaag atggggagac gggaaaaaaa 2954641 agaggccgtc ctttttccgg tgcaaatccc attccttacc cgccccaagg tgatccatga 2954701 gcgaacggta acgatacttc ggaaaaattg caacactcct aatatccgca ttcaccatgt 2954761 tggaaagcat aaaatcaatc agtcggtacc tgccggcaaa agggatcgcc ccgagcgacc 2954821 gctgtgctgt taaatcctga agagaatgct tatatgtggt ttcatctata acacctaaca 2954881 tttgattatt gaacactgac tctgccccct cttcagtaat taaatcaatt ctttttctac 2954941 aaattcctct gaaacgagca gcacctcttc aatgtctttt tcggagcgaa tcactgcgcc 2955001 atccggcagc accatcccat taggaacgat ggcattttca atgactacat gctccccaat 2955061 cgtcacatcc ggcattatga cggatgatgt aacagtcgta tgcttaccaa cagtcacacc 2955121 ttgaaaaaga acggagtgag acacatttcc atatacaaca caaccttcgt tcacaagcga 2955181 atcttgaacc tgcgcatcag atgaaataaa ttgcggaggc tgatttggat tgacggagta 2955241 aattttccat ttgcgttcaa acagcttcag ctccgagtcc tcttttaaca aatccatatt 2955301 ggcttcccac aagctctgca ccgttccgac atccttccaa tatcccttga acggataagc 2955361 agaaagcttc tttttctctt ccaaaagcag tggaataatg tctttgccga agtcgtggct 2955421 agaataaggg ttttgatcgt ccatctcaag atactgtttc aaaagcggcc aattgaatat 2955481 ataaattccc attgaggcaa gattgctctt agggaatttg ggcttttcat caaaatgtgt 2955541 gatcgtccca tctggattgg ccttcatgat gccgaaccgg cttgcttcct cccagcccac 2955601 ttcgatgaca gagatggtca catctgcttt cttttcaatg tgataatcaa gcattttgcc 2955661 gtagtccatt ttgtatatgt gatctcctga taaaatcagt acatactcag gatcatactg 2955721 attcaaataa ttgagatttt cataaatgga gcttgccgtc cctttatacc atttgacttc 2955781 tgatgactcg gcataagggg gtaaaaccgt cacgccgcca ttatatctat ccaggtccca 2955841 tgcactgccg atcccaatat aggaattcag ctcgagcggc tgatattgcg ttaaaatccc 2955901 gactgtgtct atgcctgaat tagaacagtt gcttagggta aaatcaataa tcctgtattt 2955961 tcccccgaaa gatacagccg gtttggccat attttttgtt aatccgctga gacggctgcc 2956021 cttcccgccg gcaaggagca tggctacaca ttgttttttc atctttttat ctctcctctt 2956081 tttttaaccg cccgtaaaat cgagatgccg taagggggga tggtcatcgt gatataacac 2956141 ggtttatgat gaagtgctcc ctttttagcc gataacggct ttttgttgat ttgccctgag 2956201 cctccatatg tttcactgtc actgttaagc acttcaatgt attgagtaaa aaaaggaact 2956261 ccaacatcat attgatgata gaccacgggt gtaaaattac aaatgatgac aagcgcctca 2956321 ccgtgctttt ggccataacg aataaaagaa aagattgatt gttcgtcatt atggacatca 2956381 atccattcaa acgattgtgc acgatggtca tgctcataaa ggattttgct tttttggtaa 2956441 aagcggagaa gatcttgcgt aaaaacgctg gctttctgat gcatggggaa ggagtccaaa 2956501 aaccaatcaa gctgttctgt atctttccat tcatcaaatt gagcaaactc tgatcccata 2956561 aagatcaatt tctttccggg atgcactgtc atatagccca gcaaaagccg atactgggca 2956621 aatttctgcc agtagtcgcc aggcatttta ttgagaagtg atttttttcc gtatacgact 2956681 tcatcatgag aaaacggcaa tacaaaatgt tcactaaacg catatagtaa tgaaaaagag 2956741 ataagctgat gacaatgccg cctttcttcg ggcggcgtct ccatgtattt cagtacgtca 2956801 ttcatccatc ccatattcca tttataatga aaaccaagcc ccccttcctc aacggcacct 2956861 gtcacttgag gccattctgt agaatcttct gcaatcatca tcacatgggg atatgcctct 2956921 ctcatggttt gattgagttt ttttaaaaaa tcaacagcat atggattcgt gtggcgttca 2956981 tcctgatttg gccaatacaa gatattagcc actgcatcaa ccctaaatcc atctatatga 2957041 tagaattccg cccagtacaa cgcattcgaa attaaaaaac tatgaacttc cggtttcccc 2957101 aggtcaaagt ttgccgtgcc ccataaccag ttctcccgat cacgttcttc tttgtattca 2957161 taaagcggtt ctccatcaaa catataaagg ccatgtgcat ctttacaaaa atgtccgggg 2957221 acccaatcca aaatgactcc gatattttgt tgatgacatt catccacaaa cttcatcaga 2957281 tcatgcggcg ggccaaacct gcttgtcggg ctgtaatacc ccgttccttg gtacccccat 2957341 gaacgatcat atggatgctc atacacggga agcagttcaa tatgggtaaa cccatgcttc 2957401 ttgatataag ggataagcgt ctgacttaat tctttatagg aataatgcct gccatcagaa 2957461 tgcttcttcc aagacccaag atgcagttca taaatgaaaa caggtttttc atacagcgtc 2957521 ttagccttct gtttcttttg ccatttttga tcttgccagc tgtatccttc caaatcgtaa 2957581 gtaagtgacg ctgtgtttgg tctgacttct gaataaatag cgtatggatc tgccttcagc 2957641 ctgatctcac cgttattcgt cacaatttcg tatttatatc gttccttttc tcctatacct 2957701 ggaataaata acgtccaaat gccattatca ttcactctgt gcatcacatg ctcttctcca 2957761 gaccagctgt taaaatctcc agccactcgt acttccgacg catgaggcgc ccacacacag 2957821 aattcatatc cgcttttgcc attcagctcg cggtaatgcg agccaaacag ctgatagctt 2957881 ttaaacagac tgccttcgtg aaaaagataa acatcatgtg ctgtcgggct ggcagcggcc 2957941 atgtaatcat cctttctgac atcatagttt tcatttatag tatttattcg aagaaataaa 2958001 aaaaagccct ttcctgaaag cgcttatact tatagacaat taacttcatt ttctgaagaa 2958061 aaacgaaata tatggagatt tttgtagtct gtttttaaaa taaagaacaa aatctaagac 2958121 atatcatgat ttataaaaac aaaaaaacct tgcaggatat gcaaggcttc tggatgaccc 2958181 gtacgggatt cgaacccgtg ttaccgccgt gaaagggcgg tgtcttaacc gcttgaccaa 2958241 cgggccgata attatgatat ctgtaatcat atggcggaga aggagggatt tgaaccctcg 2958301 cgccgcttac acgacctaca cccttagcag gggcgcctct tcagccactt gagtacttct 2958361 ccatttggct ccacaggcag gattcgaacc tgcgaccgat cggttaacag ccgatagctc 2958421 taccactgag ctactgtgga acaaaagtca tggtgggcct gaatggactc gaaccatcga 2958481 cctcacgctt atcaggcgtg cgctctaacc agctgagcta caggcccatg acgatataga 2958541 aatggagcgg gtgatgggaa tcgaacccac gacatcagct tggaaggctg aggttttacc 2958601 actaaactac acccgcaatt tttatttggg gcgattgatg ggaatcgaac ccacgaatgc 2958661 cagagccaca atctggtgcg ttaaccactt cgccacaacc gccaaagcat attgataaat 2958721 ggtggctcgg gacggaatcg aaccgccgac acacggattt tcagtccgtt gctctaccaa 2958781 ctgagctacc gagcctaagt atttaaatgg cggtccggac gggactcgaa cccgcgacct 2958841 cctgcgtgac aggcaggcat tctaaccaac tgaactaccg gaccatttta aaatttggtt 2958901 gcgggggcag gatttgaacc tgcgaccttc gggttatgag cccgacgagc taccgaactg 2958961 ctccaccccg cgatgattag gaatatgtat ggcggaggaa gagggattcg aacccccgcg 2959021 ggctttgaca cccctgtcgg ttttcaagac cgatcccttc agccagactt gggtattcct 2959081 ccgtatagtg gtggaccttg taggactcga acctacgacc ggacggttat gagccgtctg 2959141 ctctaaccaa ctgagctaaa ggtccattgg tagcggcgga ggggatcgaa cccccgacct 2959201 cacgggtatg aaccgtacgc tctagccagc tgagctacac cgccaaatat ttttgaaatc 2959261 aagtggagcc tagcgggatc gaaccgctga cctcctgcgt gcaaagcagg cgctctccca 2959321 gctgagctaa ggccccaaga atggtcggga agacaggatt cgaacctgcg accccatggt 2959381 cccaaaccat gtgctctacc aagctgagct acttcccgat ttcatataga tcatggcgcg 2959441 cccgagagga gtcgaacccc taaccttttg atccgtagtc aaacgctcta tccaattgag 2959501 ctacgggcgc aaaacttaat gccgagggcc ggacttgaac cggcacggta gtcacctacc 2959561 gcaggatttt aagtcctgtg tgtctgccaa ttccaccacc ccggcgtgga tggtatagtt 2959621 ggagcggaag acgggattcg aacccgcgac ccccaccttg gcaaggtggt gttctaccac 2959681 tgaactactt ccgcagaaat ggtgcggatg aagggacttg aacccccacg tctgtaaaga 2959741 cactagagcc tgattctagc gcgtctgcca attccgccac atccgcaaca tgtaaatggt 2959801 gagccatgaa ggactcgaac cttcgaccct ctgattaaaa gtcagatgct ctaccaactg 2959861 agctaatggc tcttcttaca atagacttga atattatatc atataaaagt ggtgccggca 2959921 agaggacttg aacccccaac ctactgatta caagtcagtt gctctaccaa ttgagctaca 2959981 ccggcatata tgtaaaaccg atatgtataa tgaaaaatgg tggaggatga cgggctcgaa 2960041 ccgccgaccc tctgcttgta aggcagatgc tctcccagct gagctaatcc tccatacttg 2960101 cactaacgtg caattgcttg gcggcgtcct actctcacag ggggaaaccc ccgactacca 2960161 tcggcgctga agagcttaac ttccgtgttc ggtatgggaa cgggtgtgac ctcttcgcta 2960221 tcgccaccaa acaaattgag agtgttctct caaaactaga taacaggtgt gacatcattc 2960281 aaaaatatgg ttaagtcctc gatcgattag tatctgtcag ctccatgtgt tgccacactt 2960341 ccacctcaga cctatcaacc tgatcatctt tcagggatct tacttccttg cggaatggga 2960401 aatctcatct tgaggggggc ttcatgctta gatgctttca gcacttatcc cgtccgcaca 2960461 tagctaccca gcgatgccct tggcagaaca actggtacac cagcggtgcg tccatcccgg 2960521 tcctctcgta ctaaggacag ctcctctcaa atttcctgcg cccgcgacgg atagggaccg 2960581 aactgtctca cgacgttctg aacccagctc gcgtaccgct ttaatgggcg aacagcccaa 2960641 cccttgggac cgactacagc cccaggatgc gatgagccga catcgaggtg ccaaacctcc 2960701 ccgtcgatgt ggactcttgg gggagataag cctgttatcc ccggggtagc ttttatccgt 2960761 tgagcgatgg cccttccatg cggaaccacc ggatcactaa gcccgacttt cgtccctgct 2960821 cgacttgtag gtctcgcagt caagctccct tgtgccttta cactctgcga atgatttcca 2960881 accattctga gggaaccttt gggcgcctcc gttacctttt aggaggcgac cgccccagtc 2960941 aaactgccca cctgacactg tctccccgcc cgataagggc ggcgggttag aaggtcaata 2961001 cagccagggt agtatcccac cgatgcctcc accgaagctg gcgctccggt ttccaaggct 2961061 cctacctatc ctgtacaagc tgtaccaaca ttcaatatca ggctgcagta aagctccacg 2961121 gggtctttcc gtcctgtcgc gggtaacctg catcttcaca ggtactataa tttcaccgag 2961181 tctctcgttg agacagtgcc cagatcgttg cgcctttcgt gcgggtcgga acttacccga 2961241 caaggaattt cgctacctta ggaccgttat agttacggcc gccgtttact ggggcttcaa 2961301 ttcgcacctt cgcttacgct aagcgctcct cttaaccttc cagcaccggg caggcgtcag 2961361 cccctatact tcgccttacg gcttcgcaga gacctgtgtt tttgctaaac agtcgcctgg 2961421 gcctattcac tgcggctctc tcgggcttgc accctaacag agcacccctt ctcccgaagt 2961481 tacggggtca ttttgccgag ttccttaacg agagttctct cgatcacctt aggattctct 2961541 cctcgcctac ctgtgtcggt ttgcggtacg ggcacctctc acctcgctag aggcttttct 2961601 tggcagtgtg gaatcaggaa cttcgctact atatttcgct cgccatcaca gctcagcctt 2961661 atgggaaacg gatttgccta tttcccagcc taactgcttg gacgcggata tccaataccg 2961721 cgcttaccct atcctcctgc gtccccccat tgctcaaatg gtgaggaggt ggtacaggaa 2961781 tatcaacctg ttgtccatcg cctacgcctt tcggcctcgg cttaggtccc gactaaccct 2961841 gagcggacga gccttcctca ggaaacctta ggcattcggt ggaggggatt ctcacccctc 2961901 tttcgctact cataccggca ttctcacttc taagcgctcc accagtcctt ccggtctggc 2961961 ttcacagccc ttagaacgct ctcctaccac tgttcgaaga acagtccgca gcttcggtga 2962021 tacgtttagc cccggtacat tttcggcgca gagtcactcg accagtgagc tattacgcac 2962081 tctttaaatg gtggctgctt ctaagccaac atcctggttg tctaagcaac tccacatcct 2962141 tttccactta acgtatactt tgggacctta gctggcggtc tgggctgttt ccctttcgac 2962201 tacggatctt atcactcgca gtctgactcc caaggataag tcattggcat tcggagtttg 2962261 actgaattcg gtaacccggt aggggcccct agtccaatca gtgctctacc tccaagactc 2962321 ttaccttgag gctagcccta aagctatttc ggagagaacc agctatctcc aggttcgatt 2962381 ggcatttcac ccctacccac acctcatccc cgcacttttc aacgtgcgtg ggttcgggcc 2962441 tccattcagt gttacctgaa cttcaccctg gacatgggta gatcacctgg tttcgggtct 2962501 acgaccacgt actcatgcgc cctattcaga ctcgctttcg ctgcggctcc gcatcttctg 2962561 cttaaccttg cacgggatcg taactcgccg gttcattcta caaaaggcac gccatcaccc 2962621 gttaacgggc tctgactact tgtaggcaca cggtttcagg atctctttca ctccccttcc 2962681 ggggtgcttt tcacctttcc ctcacggtac tggttcacta tcggtcacta gggagtattt 2962741 agccttggga gatggtcctc ccggattccg acggaatttc acgtgttccg ccgtactcag 2962801 gatccactca ggagagaacg aagttttgac tacagggctg ttacctccta tggcgggcct 2962861 ttccagacct cttcatctac ctcgttcttt tgtaactccg tacagagtgt cctacaaccc 2962921 caagaggcaa gcctcttggt ttgggctgat cccgtttcgc tcgccgctac tcagggaatc 2962981 gcatttgctt tctcttcctc cgggtactta gatgtttcag ttccccgggt ctgccttctc 2963041 atatcctatg aattcagata tggataccac tccattacga gtggtgggtt tccccattcg 2963101 gaaatctccg gatcaaagct tgcttacagc tccccgaagc atatcggtgt tcgtcccgtc 2963161 cttcatcggc tcctagtgcc aaggcatcca ccgtgcgccc tttctaactt aaccgttaaa 2963221 aagaatcact atgtgatatc ttgtgttact aattgaatgt gatgtctact gttatctagt 2963281 tttcaaagaa cacgtttcga aggaatgatc cttcaaaact aaacaagaca gggaacgttc 2963341 tgtttataag accttgggtc ttatattccg tataatatcc ttagaaagga ggtgatccag 2963401 ccgcaccttc cgatacggct accttgttac gacttcaccc caatcatctg tcccaccttc 2963461 ggcggctggc tcctaaaagg ttacctcacc gacttcgggt gttacaaact ctcgtggtgt 2963521 gacgggcggt gtgtacaagg cccgggaacg tattcaccgc ggcatgctga tccgcgatta 2963581 ctagcgattc cagcttcacg cagtcgagtt gcagactgcg atccgaactg agaacagatt 2963641 tgtgggattg gcttaacctc gcggtttcgc tgccctttgt tctgtccatt gtagcacgtg 2963701 tgtagcccag gtcataaggg gcatgatgat ttgacgtcat ccccaccttc ctccggtttg 2963761 tcaccggcag tcaccttaga gtgcccaact gaatgctggc aactaagatc aagggttgcg 2963821 ctcgttgcgg gacttaaccc aacatctcac gacacgagct gacgacaacc atgcaccacc 2963881 tgtcactctg cccccgaagg ggacgtccta tctctaggat tgtcagagga tgtcaagacc 2963941 tggtaaggtt cttcgcgttg cttcgaatta aaccacatgc tccaccgctt gtgcgggccc 2964001 ccgtcaattc ctttgagttt cagtcttgcg accgtactcc ccaggcggag tgcttaatgc 2964061 gttagctgca gcactaaggg gcggaaaccc cctaacactt agcactcatc gtttacggcg 2964121 tggactacca gggtatctaa tcctgttcgc tccccacgct ttcgctcctc agcgtcagtt 2964181 acagaccaga gagtcgcctt cgccactggt gttcctccac atctctacgc atttcaccgc 2964241 tacacgtgga attccactct cctcttctgc actcaagttc cccagtttcc aatgaccctc 2964301 cccggttgag ccgggggctt tcacatcaga cttaagaaac cgcctgcgag ccctttacgc 2964361 ccaataattc cggaaaacgc ttgccaccta cgtattaccg cggctgctgg cacgtagtta 2964421 gccgtggctt tctggttagg taccgtcaag gtaccgccct gttcgaacgg tacttgttct 2964481 tccctaacaa cagagcttta cgatccgaaa accttcatca ctcacgcggc gttgctccgt 2964541 cagactttcg tccattgcgg aagattccct actgctgcct cccgtaggag tctgggccgt 2964601 gtctcagtcc cagtgtggcc gatcaccctc tcaggtcggc tacgcatcgt tgccttggtg 2964661 agccgttacc tcaccaacta gctaatgcgc cgcgggtcca tctgtaagtg gtagccgaag 2964721 ccacctttta tgtttgaatc atgcggttca aacaaccatc cggtattagc cccggtttcc 2964781 cggagttatc ccagtcttac aggcaggtta cccacgtgtt actcacccgt ccgccgctaa 2964841 catcagggag caagctccca cctgtccgct cgacttgcat gtattaggca cgccgccagc 2964901 gttcgtcctg agccaggatc aaactctccg ataaatggat cacaggttaa gttcaccgca 2964961 tcctgcggcg acacctgtgt gacctgcgtc gtgcaggccc tagtttgact gactacgcac 2965021 atcgcagtgc gatttttaaa aactgaatta acaggtacgt tttgtcttgt ttagttttca 2965081 aagatcattt cgttacttct caatgaagca gctttactaa tataacattc agcttctttt 2965141 ttgtcaacaa cttttttcaa gttgttttga agcatctagt ttgtgtccgc tgtgcatcag 2965201 cgacgtttaa taatataaca cctgtattta tttattgcaa tagtttttta aaaaaaatct 2965261 ataaaacaaa taaactataa tcctcgccat gatttctaaa gcgtgtgtat catataagtt 2965321 tcttaaaaga acatatacat cagtcatgtg atcttgttgt ttttttcgtt ttcttgtata 2965381 gtagaaacga actaaatact gatgaccaca aggggagcat taaagctgag agtgagcggt 2965441 ttcgttctga ccctttgaac ctgttagtta acgctggcgt agggatgtgg caaagtcaaa 2965501 tgaattgcag atcgtaaagc agtgcgtgga acttttctca tccttccgcg tgctgctttt 2965561 ttgttgtcct tttggttgtc tgtcaatgga aggagataga tatgaatcaa tctaagcaac 2965621 tggttcgcct tattgaaatt gccattatga cagcggcagc cgttatttta gacattgtct 2965681 caggaatgtt tcttagcatg cctcaaggag gctcggtctc catcatgatg attccgatct 2965741 ttttaatttc gtttcgctgg ggtgtcaaag caggtcttac tacaggtttg ttgacaggtc 2965801 tagtacaaat agcaatcgga aacttgtttg ctcaacatcc tgtacagcta ttgttagatt 2965861 acattgtcgc tttcgcagca atcggcataa gcggctgttt cgcttcttct gtccgtaaag 2965921 ccgctgtatc aaaaacaaaa gggaaattga ttgtttcagt ggtcagcgca gtttttatcg 2965981 gcagtttgct gcgctatgcc gcgcatgtca tttcaggagc tgtgtttttc ggcagctttg 2966041 ctccaaaagg aacaccggta tggatttatt ctttaactta taatgcgact tacatggttc 2966101 cttcattcat tatttgtgca attgtcctat gtttattatt tatgacagca ccccgtctgc 2966161 ttaaaagtga caaagcgtaa aagtaacaat cccccagcga attccgctgg gggatttttc 2966221 gttatctgtt aagaagtgtt tttaaagctg aaagatccgg ccagccaaga cctacttctt 2966281 tcagccttac tccggcaatt tcaaagttgt cctccgctac tctttcaggt gaataggcct 2966341 gataaaatat aatcgaggga ttctgctcaa taacccaaac aaacatactt gaaaaaccat 2966401 gttgaagcaa aaactccgct ccttttgcta agagcgccct gcctgcacct tgccgctggc 2966461 gctcttccag aagataaata gcgtataact cgccgtcata gccttcttgt tcagagcgaa 2966521 taggtccaaa tgaagcaaag ccgaatactg aacccttttc gtcctgagca acaaatactc 2966581 cctttaacga gcgacttttc catttgtctt caaattcctt atagttcagg ctgtttaaat 2966641 aatcaatcgg gataatttcg tggtatgttg tcctccagct gtctacatgc acttttgcaa 2966701 tgtcctttat atcctctaac ttcgcttcac gtacagttac catacggttc tgccctttcc 2966761 ttactctgat ttttggatcg ttttggcttc tttgatttca tttgttaatt cattaatgct 2966821 ttgttttacg tttccttttc ctgaaaagtt ctcaagcatt tcttttacat caattcctga 2966881 ggatgctttt aaactttctt gcagacttga cattaagttc gtcgcatagc tggttacttt 2966941 gtttgctccg cttgattcac cgcttcctcc tgtatcgaca acggtgattt tatcaatatt 2967001 tgaaagaggt gccgctgctt gtttcgcgta ttccggaagc attttgacaa tcatatcgaa 2967061 aatcgccgcc tgcccgtact gttcaaaggc ggccgcaatt ttctcttttg cttccgcttc 2967121 tgcaagacct ttcaggcgga taacctctgc ttctgtctct cctttcgctt tttccgcttc 2967181 tgcttttgct agcccgtcaa ttcttacttt ttccgcctca gcctttgcca ttgcttcaat 2967241 actgtacttc ttggcatcgg cttccgcgag ctgtttggct ttctcagctg ctgcggactg 2967301 ctcaacagaa taacggtctg catcggcttt tttctttacc tctgagtcgt attgacgttc 2967361 acggcgaaga atttcttttt cttctagttc tatttgtttt tggcgttcga taattttaac 2967421 ctgcatttcc tgctctgtga cttgctggcg cgctcgggca gtctctaaat catatgcttg 2967481 gtcggcattc gcttttgccg tatcttgttc tctgcggaat tcagccattt tgagctgatt 2967541 gattttttca gcttcagcga tttccgtcgc ccgttcaagt tctgattttt ttgcgtcttt 2967601 atcggcttct gcccgcttaa ttcgggtttc tttatcagcc tctgctgttg cgatatcagc 2967661 atcgcgtttt acttgggcaa ttctcggttt ccctaatgat tcaagataac cgtttttatc 2967721 acgaacatct ttaatggtaa acgagacgat tacaagtccc attttcgcga gatcctgtga 2967781 agcgacacgc tgcacctctt gagagaattt ttctctgttt ttatagattt cttctactgt 2967841 cattgagccg agaatggaac gaaggtggcc ttctaaaacc tcccgcgctt cctgctcacg 2967901 gtcgtctttt gatttcccta aaaattgttc ggccgctgta gcgatttctc ctatagaacc 2967961 gccgatttta ataatcgcag ttccatcggc cattactggc actccttgtt ctgtatagac 2968021 ttcaggtgtc gaaacatcga gtttgcttga taataggctt agcggctctg cctgctggaa 2968081 gacgggaagg acaaaggttc ctccgccgcg gacgatttta atacggttgc cgccttcatc 2968141 gacatgaaca tttttattac ccagatagct ccctgttaca attaacgctt catcaggccc 2968201 tgctgtacga tacttcgtaa taaacacagc tattagtgca attaataaaa agaatacaac 2968261 tccgatgatc attataatcg gcattgtcat atcaaattcc tccttttatg ttaaatgggt 2968321 tcatgcggag taaccgaaag aactccgttg ttaatatcta cgactaacac cgttgtcccg 2968381 taactgatct gctgattatc aaaactgacc gctgactttg aaatggtccc gcctatccct 2968441 tctatgacca cttcaccaaa cccgtcaacc ggcacagctg taatcacttt accgagtctt 2968501 cctctgagat catcttctct atatgccaat gattcttctg cagatgataa tggcaccagt 2968561 acaaagatgt gaagcaatac caccagcatg atcgaaagga tgcaagataa aagcgcaatc 2968621 agcaagcttg acagaggcaa tacaagttca cctatatatc cgcccgctga aaaacatgta 2968681 aaaaatgaga gcactaatgt cggattaaga aacggaatgc cttctgacag ccctgaaaat 2968741 acatctccga aaaacaggaa taacagcgta aggctgcccg caataataag cgtataaaga 2968801 tacattgttt gtataggtac tccaaataac tccaacttcc tcatcctttc ttcatcaatg 2968861 cattgatgaa cggctgccgt taccatttat acgagacacc tcgggaaaag tttcaaaatt 2968921 ttaagacaaa taacccattt gaagtgcttt ataaatgata attgcttata tatatggtaa 2968981 tgtcatttta ggaggagata tgatgagtat ctttaatgaa gccagattag aaacgtggaa 2969041 cgaattgaaa ggactttctg acgaaaagct gaatcaaaag ccttctgctg aagaatggag 2969101 catacgggaa gttcttgacc atttgaaaaa aatcgatatg accgcacaaa aaatgttgaa 2969161 ggaacgtgta aaggacgctc cgattaaaga aattgaagaa aaaccgcttg aagtagcaca 2969221 ggacagaaat aataaacgga aagccccgag tcatcttgag cctgcgcatg attttatttc 2969281 aggcagccaa atgaaacgtg agcttgatgt ggtaagagag cagctgactg ctgcgattgc 2969341 ctctctgaaa gaagaagatt ttgaaagagt gcttccgcat cctgtgtttc aagagctgac 2969401 tgtcagacag tggatcgatt ttatcggcca tcatgaaaaa cggcacctca gccaaatgaa 2969461 agaaattaaa gaaaagatag aaagggcctg atttaatcag accctttctg cttttcgttt 2969521 gacttttcgc tgataggaat gaacttctat ttcatcacct gtgtaaacag caccaggtct 2969581 ctccacaata cagacaatcc ctctaatgcc cagtgcgtgg cggacgaaag ccgacgccag 2969641 cttcggttgg tccggataat aagactgaat gacttctccc ggctggatac acggatcatt 2969701 ttcgccctca cacagcagag ccgctccgct cggaaaaata atccggcttc cttcttttaa 2969761 tgaagtaaga tctggcatac cgctgactgc cacattcgcc ccgagccatt ccggcaaaat 2969821 tctcggcact cccattttta aagcgatttc gttgcattcc tctattgaaa caattgaaat 2969881 ttgtctgcgg ttgaaaattt cagtccctct tgaaaacatt ggttctctgg ctcccgcttt 2969941 tttggtcagg ccaaaatgca agtcgccggg gatgccgcca taatcaaaat caagcttgtc 2970001 catttgcttt gttacgaagc tttttgtatc tgcgatatat aagccttccg cttttgcagt 2970061 catacgcttc cacatcagct ggcaccttcc ttcttatcta aaatttccac ctatgcttca 2970121 ttatcccaaa aaatcccgct ctgtaaagga gcgggatttt gattataccg ttttaggcgt 2970181 aaggttaaag cagcgtttgt agatccagtt gtatgctttt tcatttaaat ctctagggtt 2970241 tccgaaggtt tgcggatctt tcattgcttc tttagacaag cgttcgatca tatcaggtga 2970301 tactccctgc tcttctaaag tcggcacttc taaatcttcg accagatcat acatccaatt 2970361 gacagatgct ttcgcagctt cttctgttgt catcttgctt gtatcaatac cgaacgcttt 2970421 cgcaatacgc gcaaacttct caggatagcc cttccagttg tattccatga cagggcccat 2970481 catcgccgct acacattggc cgtgagcgac tgggataata ccgccaagcg tttggctcat 2970541 cgcatgagca gcgcccgctg attcacttcc gtaagaaaga ccggcaagca tcgcagcctg 2970601 cgccattccg taccttgctt ccagatcctc tccatcagca aatgccctct tgatgtaatg 2970661 agcggcatac tcaatcgcca ttaaggcaac cgcatccgtg attggctgtg caaatttcat 2970721 tgtatagcac tcaatggcat gggcgagcgc atcaattccc gtcatagctg ttacatgcgg 2970781 aggcattgaa acatgaagct caggatcaat gattgtcaag tgcgctgcaa tcagcggacc 2970841 gcccgtgttg aatttgaatt ctctttcttc atctgtgata accgcccatt gggttacttc 2970901 tgatccggtt ccagctgtag tgggaattgt cgtcagcgga ggaatgcggt tttccagcgg 2970961 ttttttccca tctgccgctt cataatcaag cacgcttcct tcgtgagtcg cttctactcc 2971021 gattgctttt gctgtatcca tggagcttcc gcctccgact gccaccaaac cattacagtt 2971081 ctcttttttg taaagctcag atccttcatt caccagacgg acaggcgggt ttggctcaac 2971141 tttattaaag agtaccactt caatgcctgc ttctttaagt gattcgatta cgggatcagc 2971201 aacaccggct ttataaatcc cagggtctgt gacaaggagc gcttttgaaa cgcccagtgc 2971261 agctacttcc tcacccgtat gcttgatggc tccgattcca tgcttaatca cagtcggaat 2971321 ttcaaatgtg tggaatttct gcatgctttc taccttcata tttaatgtca tcatcaatct 2971381 ccccctctta tgaattaaac cagttaaccg ctgccggttt tgtattgcgg tatacatgtt 2971441 tgacttctgt gtattcttca aggcctattt ttccaagctc gcgtccgaac ccggattgct 2971501 tatatccgcc ccatggcgct tgtgcaaagt acggatgaaa atcgttgatc caaacggttc 2971561 ccattctcaa gcgggctgct acccgttcgc acttttcaat gtcttttgac cataccgctc 2971621 cagccaagcc atagatggta tcattcgcaa gctcgattac ctcttcttca gagctgaagg 2971681 tttcgactgt caatacagga ccgaaaacct cttcctgaac gattctcatg tcagaattac 2971741 agtttgagaa aatagtaggt tcatagaaaa agccgttttg aagctcagga tcttccgggc 2971801 gtttgcctcc tgtctccagc ttcgcgcctt cctctattcc gatctctaca tatttttcta 2971861 cctttgccct gtgctccgcc gaaataagcg gaccgctttc tgtctcagca tgaaaaccgt 2971921 ttccgagttt tatgcgtttt gcccgtttga ccagctccgc caaaaattga tcatgaatgg 2971981 catcctcaac aagcaagcgg gaacctgcag agcatacttg gccggcgtgg aaaaatacag 2972041 cgtttaaggc ctgatcaacc gcaacttcta aatccgcgtc cttgaaaaca atatttgggt 2972101 ttttcccgcc aagttcaagg gcgatttttt tgacgtttcc gcttgccgcc cgcatgattt 2972161 ttttgcctgt ttcaattccg cccgtaaatg aaatcaaatc gacgtctttg tttacggcaa 2972221 gctcgtcgcc cactgtggct cccggtccaa gaacaagatt tgcgacacct tttggaacac 2972281 cggcttcttc catcagctta aagactttga ttgtcgtcag cggcgtaatc tcactcggct 2972341 tcatgacgat tgtgtttcct gcggccagtg caggggcgat tttccagctc gcttgaagga 2972401 gcggataatt ccatggagtg atctggccgc aaaccccgat tggctcccta ataattttgc 2972461 tttctgaatc aggaatcgga gatgaaatga tctctccgcc atctttgtct gccaagccgg 2972521 cgtaatattg aaaaacattg gcgatatcgt ccatatcggc cttgctttct tcgagtgttt 2972581 ttcctgtatc aagagattca agctcagcca gctcctcaag atcgcgtctg attaattccg 2972641 caattttcag aacaattttt ccgcgttcaa gcccggatag cgatgaccat tctcctttgt 2972701 caaatgctct acgtgcggct gcgattgctt tgatggcgtc ctctcgccct ccctcgctta 2972761 cagttgcaat ttcttcttga ttaaatgggt tgataatact gcggatctgt tctttttcgg 2972821 cactgatcca ttctccgtca atgaataatg tttgactcat ataagcctcc ttgacgtaaa 2972881 taaagtttgt taaataaaaa tttaatgttt ttaacaacct taatctaaca tatggttttt 2972941 aaactgtcaa agtcccattt tgatttttct ttttgacttt tcctcatgtt tcgttaagat 2973001 aaagaacata aagaaataac ttaacgaatt taattttcta aaggaaaaga gggtcagtat 2973061 ggatgaaaat ccagaatttg cagctataga acaggctcgg gatcttgtta ttgactccat 2973121 tgctgaaacg atggatcttt acggaattac ccgcagtgtc gggattttat atgggacgat 2973181 gtatatgagg gatgagatga cgcttgacga aatgcgtgag gagttgcaaa tgagcaaacc 2973241 aagcatgagc actggcgtca aaaagcttca agacttaaat gtagtgaaaa aaacatttca 2973301 ccggggcatc cgcaagcata catttgtggc tgagaaggat ttctttaaat ttttcacaaa 2973361 tttctttcca cctaaatggg agcgggaggt tcaagtgaat gtaacagcga tcgaggaagc 2973421 tcaagctgat ttacaaaagg ttttatgcaa ggaagatctc gatgaggata tcaaaaatga 2973481 agcactgcag ttatatgatc agctggaaag ctctaaagct tactatgact ggctgaaacg 2973541 gcttgctgaa tcggtgcaga ccggagaaat ttttaaattt ataccggtcg aaacaaagta 2973601 aagcagaaaa cgcctgggaa actaggcgtt tttttgatgt aactactaca aatttgaaaa 2973661 atacgggaaa aacaccccat ttacttccaa aatatttgat ggtaatttta tgtaggtaaa 2973721 atttgtattt ggcctttcag aggaggtgaa aagcgggcag gcctgtttaa tttatcattt 2973781 tttaggggga attttgttat gaaacgcaaa ttattatctt ctttggcaat tagtgcatta 2973841 agtctcgggt tactcgtttc tgcacctaca gcttctttcg cggctgaatc tacatcaact 2973901 aaagctcata ctgaatccac tatgagaaca cagtctacag cttcattgtt cgcaacaatc 2973961 actggcgcca gcaaaacgga atggtctttc tcagatatcg aattgactta ccgtccaaac 2974021 acgcttctca gccttggcgt tatggagttt acattgccaa gcggatttac tgcaaacacg 2974081 aaagacacat tgaacggaaa tgccttgcgt acaacacaga tcctcaataa cgggaaaaca 2974141 gtaagagttc ctttggcact tgatttgtta ggagctggcg aattcaaatt aaaactgaat 2974201 aacaaaacac ttcctgccgc tggtacatat actttccgtg cggagaataa atcattaagc 2974261 atcggaaata aattttacgc agaagccagc attgacgtgg ctaagcgcag cactcctccg 2974321 actcagcctt gcggttgcaa ctaatgtaaa agaccggtta acgccggtct tttttgcgtt 2974381 ttaccctccc ctttttctct aatccccgtt atcttttttc tggtttaaaa tttaaattga 2974441 caaacactag aaacaggagt aaattcttga gtgttcaatt tcatacagtc tcttttaccg 2974501 cttaatcaaa cacgaacggg ggaaccaacg attggctgtt ttattaacag ccttggggtg 2974561 aatcttacta agtaagaggg ggtactctga atccctaatc cgacagctaa cctcgtaggc 2974621 gtatacagag aggaggtcta ttatcggcca ttctttgcaa tggtcttttt tgtttcaaaa 2974681 acgttaattc actaagggag atatgaacat tgggaagaat taaaaataag caatttgccg 2974741 tgatcgggct gggccggttt ggcggcagca tttgtaaaga acttcataga atggggcatg 2974801 aggtccttgc ggttgatatc aacgaagaaa aggtcaatgc atatgcttct tacgccactc 2974861 atgcggtaat tgccaacgcc accgaagaaa acgaattgct ttcattagga atacgcaatt 2974921 ttgaatatgt gattgttgcc atcggagcaa atattcaagc gagtacgctg accaccctat 2974981 tattaaagga gcttgatatt ccaaatattt gggtgaaggc tcaaaactat tatcatcaca 2975041 aggtgcttga aaaaataggc gctgaccgca ttattcatcc tgaaaaagat atgggggtta 2975101 aaatcgcaca aagcctttca gacgaaaatg ttttgaatta cattgatcta tctgatgaat 2975161 acagtattgt cgagctgctg gctacgcgca agcttgattc aaaatcgatt attgacctga 2975221 atgtaagagc aaagtacggc tgcacgatcc tggccattaa acatcatgga gatatctgtc 2975281 tttcccccgc gcctgaagac atcattcgcg agcaagattg cctggtgatc atgggccaca 2975341 aaaaggatat taaacgtttt gaaaacgaag ggatgtagac aaaggtgaca cttcaaaagg 2975401 ataaagtgat caaatgggtt cggtttacac cgcctcaagt gcttgccatt ggttttttcc 2975461 ttaccattat catcggggct gtcctattaa tgcttccgat ttccactacg aagccattgt 2975521 catggataga tgcccttttt actgcggctt ccgctacaac tgttacaggg cttgctgttg 2975581 tcgataccgg cactcaattt acggtattcg ggcaaacagt aattatgggg ctgattcaga 2975641 ttggcgggct tggatttatg acatttgcgg tcttgatcgt catgatatta ggaaaaaaaa 2975701 tcggcttaaa agaacgaatg ctcgtccagg aagccttaaa ccagccgaca atcggcggtg 2975761 tcattggcct tgtcaaagtc ctgtttctgt tttcgatcag tattgaattg atagcagcac 2975821 tcattttatc catccggctt gtacctcaat acggctggtc atccggcttg tttgcaagtt 2975881 tgtttcacgc aatatctgct tttaacaatg ccgggttttc gttgtggcct gataatttga 2975941 tgagctacgt tggcgatcct acagtgaacc tcgtgattac tttcttattt attacaggag 2976001 ggatcggatt tacggttctg tttgatgtga tgaaaaatcg gcgttttaaa actttttctt 2976061 tacatacaaa gctcatgctt acaggaacgc tgatgttgaa tgcgatcgct atgcttacgg 2976121 tctttatttt agaatacagc aaccccggca cgctcggcca cctgcatata gtggataaac 2976181 tgtgggcctc ctattttcag gcagtgacgc cgagaaccgc agggttcaat tctctagatt 2976241 ttggaagcat gagagaagga acaattgtat ttactttatt attgatgttt atcggagcag 2976301 gaagcgcatc aacggcgagc ggcattaagc tgactacgtt catcgtgatt ttaacatctg 2976361 ttattgctta cttgagaggt aaaaaagaaa cggttatttt ccgccgttcc atcaaatatc 2976421 cgattatcat taaagcttta gctgtgagcg tcaccagttt gttcatcgtg tttttaggga 2976481 ttttcgccct gacgatcaca gaacaagcgc catttcttca aattgtgttt gaaacctttt 2976541 ccgcattcgg aactgtcggc cttacgatgg ggcttactcc tgaactgaca acagctggca 2976601 agtgtatcat cattgtcatc atgtttatcg gaagaattgg tcctttaacg ttcgtgtttt 2976661 cattcgcaaa aacagagcaa tcaaatatcc gttatcctga tggcgaagtg tttacagggt 2976721 gatatcaaaa aaatccggcg tgcagtcgcc ggatttttta tgattcgata tgagattgat 2976781 tttgtctttt ttcctgttcc gcgatgattt cgttatcctc cgcgttatca cgggtcactt 2976841 tttgcgtaag aatcgcacca actgctacaa gtatcataac agcgatgtaa taaccttttt 2976901 cattgagttc cagattatca gcattataga gtccgatact aaacaaaaat actcccgcaa 2976961 aaaaagtaaa ataagctagt actgtaaagg caaccgtgtt tctgcgtcta tatttctgca 2977021 cctttgttcc ctcccgaaag catagttaaa aagtgataac ttccgtggaa tattatacct 2977081 caaattcccc ggaatggaac aaagaattaa aaataccagt aaaaagggct taggttgcct 2977141 cctttatttc aacagctgaa tcatcaatcc agccgataag tttatcattg atttggaatt 2977201 ggtaccatac agactggcct ttctgttttt tagacacaac ctttatgtct ttgccgacgt 2977261 aagattgggc agaggtaagc cttatggacc gatcatcagt agaaggcttg gaccatacgt 2977321 cttgaacggc actgtcttta atagaggcgt ttaaatccac agatttgagg gatggattta 2977381 cctcatcgta ctcatctaaa tcgtattttt ccacaatagc gctgattttg tcagcgtagt 2977441 cagggtctgt agcatatcct gatgtttgca gggcggttgc cgcttcctta taattccctg 2977501 cctcaagcac cggtttatac ttctttttat tccacgatgt gccacggacg aacaattggg 2977561 cgtgatcatc catagattca aaaaacgtgc tgtattttcg aaacttcgcg cgaatggttt 2977621 ttcttttccc tttttcaact tcgtccgttt ccatcgtgac atgatggcct ttataattcc 2977681 cttttacgcc aaaaaggttg ttggccttag cagccagttc actgttcccc cagtccgatt 2977741 cgagaatggc ctgagcaatt gtgatgctgg ggagaacatg gtatttttca tacaaaattt 2977801 gggcatgtcc ggacagactg tctataaata cttgctgttc atcgatttct tcagtttctt 2977861 tggatatttc aatcggtttt gataaagttg tcgctaaaac aaacagagct agcggaatcg 2977921 atacaaggaa aaatagtgaa atcaagagtt tacgtttttt aagtttttta cgggccatga 2977981 aaaccttcct tcgaattaaa agattacgaa tgtaaaagaa tctacctttt agaattttac 2978041 ttgcacttct aatatttttc aattctttag ggataaagtt gggaaaagat tgcaaaataa 2978101 aaaccttttc gctcaatgaa aaggttttta ccatgtttct atttttgtaa atttctgagt 2978161 gcattccgat attccgtatc atttattact ttatatgatt tgacagttgc cttcgacaaa 2978221 ccttgtgctg agacggccgg tttttccgga gctgttttcg ctttatcatg tggtttatgt 2978281 gccagcttgt gccccattcc agtggcattc atacaaaatg acaggcagac gagcagcacg 2978341 ctaaggataa aagaaatgaa gaagagatca tgataagcag tcatcataga atcctgtacc 2978401 gaaccgcttt gtctggcagc atcttttttc gtgaaaaagc cgatgagaat gggaactccc 2978461 atatagacaa acaatcttaa aaactgaaca gctgtcattc tcttgaccaa atcaggcagc 2978521 gggcctccca tggcagctcc catcagccct gcggcgactg tcaggcctgt tcccgctgca 2978581 agcatgataa acagtgccgc gaacatataa agagatgatc gatcctgtat atgcagccat 2978641 tgaaaattca caaaaacgag aatgagtccg ccgataatac cgagcatccc tggtccgact 2978701 ttatcgtata acagagcgct caaaatggcc gcgatcgcca ctccgattaa aagagtcaag 2978761 cttaaaagaa tgagatgctc ctgagaaata tcatacattt gacggagcaa gccttgaaaa 2978821 gcagaaaggc tgacagctac cgttatcgtc cctgcagcta tgatcaataa gccgagcacc 2978881 ggttttggca gcagcatcag tttaatagat atgaaggggt ttttcacttt atattccaca 2978941 atcaatagac caatgagcaa acataacgtc accccgaaac caatccatac ataacccgat 2979001 gacagccccc atttttgcag aaaaatgaat gaaaccgctg aggctgcggc aaggaagaca 2979061 gataaaagaa ttcccgcacg atcaagcggc tgttcttgat ccgccgctcc gtgatgctca 2979121 tcatgaagaa agaaatagct caccgcgaca ccgatcaggg acaaggtgcc aaagatgaaa 2979181 aacagccatc tccaatgccc gcagcttgtt gcaatggttc ccaggattgt accgatgata 2979241 acagaaccat agaatccccc gatcagcaca agcagtgcat agttcctgcg ttcaatcggg 2979301 aatgacagta caagcattgg aatcataatc atcagcatga cgcctgttgc cgccccttgt 2979361 aaaaagcgcc ctgccgccat caatgcaata tcgcctgaac atgcgatgag cagtgagcct 2979421 agtataaaga caggtaatga agccagatag acgggacgag caccgaattt tttcctcagc 2979481 agcggtcctg ccggaactaa caaggcaaag gccatattgc cgatcaatat cggatttact 2979541 gatgtaaaga cacttgttcc aaccgttttc tgaacaaggc cttgaactga cgacaatgcc 2979601 gtgttagaca tcaatcccgg cccgaccgct aagacggcga gcaaagaaat cacccaatag 2979661 tgttttgtct tcatgttgtc atcccttcct atatgaatac atgcgaaaca catcattttt 2979721 tgaaaacaaa agaagctaat agattttgca taccattagc tttcattcta atattctccc 2979781 tttcagggga aatgatatta ttttattata attatgtgaa tgaatgagca tataatcaaa 2979841 tattatttca aatcgattgt gttttgtcaa tggagtaaat ttcaagcaca acatagaaag 2979901 cttgaaagct tttccccgat attgtgtcta gaactgcact tatgaatccc tgctcgttcc 2979961 ctcaagcgaa ttaaagcagg ccgttttaat cctttcaatc cactattcca actaataaac 2980021 tcaaataagt tggtgataag acaacatttt acccccacat ttttttgtgt tcactgggcg 2980081 tttgccgcct ctaaattgta tatgggtaaa taccatgaat taacctatga aataccaatg 2980141 taagggaggc aaaaacgaat ggaactgtat gagtgtatcc aagacatttt tggcggcttg 2980201 aaaaatccat cggttaaaga tttagcaacg tctttaaaac aaattccaaa cgcagcaaaa 2980261 ttgagtcaac cgtatattaa ggaaccagac cagtacgctt acggccgaaa tgccatctat 2980321 cgaaataatg aattggaaat tatcgtgatt aacattccgc caaacaagga gacaacagta 2980381 cacgatcatg gtcaatccat tggttgtgca atggtgttag aaggaaagct tcttaattct 2980441 atttatcgtt caaccggcga acacgcagaa ctctccaatt catactttgt ccacgaagga 2980501 gaatgcctta tttcaaccaa aggtttaatt cacaaaatgt ccaatccaac atctgaacga 2980561 atggtgtctc ttcatgtcta ctcccctcct ttggaagaca tgacggtctt tgaggaacaa 2980621 aaggaggtat tggaaaattc atgattgaca gataaactgc tcactttgac ttcactcaac 2980681 tggaggattc agagaatgaa accttttcct caaaacaaaa aaacccttat cgaataaggg 2980741 tttaaaggta tggagccaag ggggctcgaa cccctgacct ctacgctgcc agcgtagcgc 2980801 tctcccagct gagctatggc cccgtatgta acgtcatgtt tattatagat gattttattt 2980861 tgaaaaacaa gctgtttcct cttgaattga cagaaaaaat aaggctcgga aaagagcctt 2980921 atttttcgac ttacatcatg atcaaaagta aaatcacacc gagaataatt cgatagattg 2980981 caaatgggac aagtttgatt ttgttaatca gccttaagaa gaaacggacg acaaacagtg 2981041 cgaccacaaa ggcacagata aagccgacga tgaaaaacgg catcagatcc gaacttaagc 2981101 tgtcccaatg cttcacgagg cttagaaagc tggctcccat catgatcggc atcgccataa 2981161 taaacgtaaa gtcggctgca gctcggtggt ttaatccgag aataacaccg ccggaaatgg 2981221 ttgaacccga acgcgagaaa ccaggccaaa gggaaagaca ttggaataag ccgacggcta 2981281 tcgcctgttt ataggaaatg cggtcgagtg tgtctgtcgc tgttttccgt ttattgaccc 2981341 agtcagcaaa aagcatgagg attgccccgg caattaaacc gatggccaca gttttaacgg 2981401 aaaataaata ttcatcaatg taatcttcaa acaaaaagcc gagaacagct gcaggcacga 2981461 gtccgacggc aatttgggca atgcttaatt tatgtccctg ctcctggtcg cttgtaatat 2981521 tttttttcaa gcccagtaaa tttaaaattc ggtctttaaa cacgatagct actgctaaaa 2981581 tggagcctag ctgaataacc accttgaatg agttagcagc ttcttctgac atcagattac 2981641 ttgattttag ccagatgtcg tctactatga tcatatgtcc tgtcgaagaa accggcgcgt 2981701 actctgttaa tccttctacg attcctaaaa tggcggctac aaacaattcc catagagtca 2981761 tgattttgat tctccccatt agacatttat ttttttacat aacgggagct tcccataaat 2981821 ggaaagcccg tcttatataa ctataaacga aaatcacact ttatgccccg gcgtattttc 2981881 atttttttct tcatcgtata aatgtgactg cattttaaac cagtcaaata aatgtgtcgt 2981941 aatgactttg gcaaccgcat agccgggaat cgcaagaatg attccaacaa cgccaaacag 2982001 cttgccggct gttaacagca gaaaaataat cgtaatcgga tggatgtgaa ggttttttcc 2982061 cataatttgc ggagagatca gcttcccttc aatcagctga acaatcgtcc aaacgatcac 2982121 cagcttaagc agcatgagcg gcgatgtcac tatggcaatg ataatcgcag gcgtaatggc 2982181 aatcgttggc cctaaatatg gaacgatgct tgtgcaagcc gcaatgactg caagcaatga 2982241 agcataatcc agcccgataa tcaaataacc gataaacagc aaaaacccga tacagaagct 2982301 gacaatgatc tggcctctga tataagagct taaccgatga ttcatttcgc ttaagactgt 2982361 atatgtctgt tctttcaatc gagtcggcac aaacttcagt atgtagaccg gtaattttct 2982421 tccgtctttt agcaaataaa atagaataaa cggaaccgtg acgatcgaaa tgataatctc 2982481 agtcagtgcg ccgataaaat tcccaacacc ggtaaaggtg ctgttcacga tcgtcgctgc 2982541 ctgatccgaa acctttgtag caagatcaga tatattaatg ttcatcgttt gctgggcctg 2982601 attgacgaag ttgctgccaa tcagctgttt cgtctgattt tctacgacgt ccacatatct 2982661 cgggatattg tcaatcaaac tcataatttg ttcttttaag aagggaatga tcgacacgat 2982721 cgtgatcgtg atcagcccga taaccaatag gtatagcagc aatatagaat agattcttct 2982781 tattcttctt ctctccagaa aatcgacgac tgggtttaac agataaaaaa caatgcctgt 2982841 caaaataatc ggaagtgata tcgttttgag cagaacaata atcggggtga aaataaatga 2982901 tgtttttgta aatactagaa tatttaaacc aatcagcagc agcacaagca aaaataaaac 2982961 aaacttatta tccaagaaga atcgcttgaa tctgccgctc catgtttgca acgtctccac 2983021 tatcgttcct ccgtcataca tagtttaatt aaattgtaca ctatcgtccc tataatgaaa 2983081 aataaaaacc gttaattgct ggaaaagctt tctcggtttt aacattctat ttatatctat 2983141 catgtgattt tgttcttttt aagctataat ttagctatat catgcaaaag gagcgatacg 2983201 agtgatacgt tttgcaataa taggaaccaa ctggattaca gaccgctttc ttgagtcagc 2983261 agcggatatc gaagattttc agctgactgc tgtttattca agatcggctg aacgcgctgg 2983321 cgagtttgct gctaaacaca acgctgcgca tgccttctca gaccttcagg aaatggcggc 2983381 gagcgattgc tttgatgccg tatacatagc gagcccgaac gctcttcaca aggaacaagc 2983441 cgttctcttt atgaaccatg gcaagcatgt gctttgtgag aagccgtttg cttcgaatac 2983501 aaaagaaaca gaagagatga tctcagcggc taaggcaaac ggcgttgttc tcatggaagc 2983561 aatgaagacc actttcctgc cgaatttcaa agaactgaaa aaacacctgc ataaaatcgg 2983621 cactgtccgc agatttaccg caagctactg ccagtattcc tcacgatatg acgcgttcag 2983681 aagcggaact gttttgaatg cgtttcagcc tgagctttcc aatgggtcat taatggatat 2983741 tggcgtctat tgtatttatc cggctgttgt gttgtttggc gcgccgaagg atgtaaaagc 2983801 aaacggatat gctttatcct ccggagtgga cggagaagga actgtcattc tgtcttacga 2983861 cgggttcgaa gctgttctga tgcattccaa aatctctact tcctatgccc cggctgaaat 2983921 ccagggtgaa gacgggacga ttgtaatcga tacgattcac cggcctgaac gtgttgaaat 2983981 ccgctaccgg gacggccgcc ttgaaaacat cgcgatccct gatcctaaac cggcgatgtt 2984041 ctatgaagca gaagaatttg tcacgcttat aaaagagaat aagctggaat ctgaagaaaa 2984101 tacatttgaa cggtctttga ccaccgcaaa aattatggaa gaagcaagaa agcaaatggg 2984161 gattgtatac cctgctgatc aagcttaaaa aaatccgccc gcgtgcaaat gccgcggcgg 2984221 attttttatt agacaatcgg agaagatgcc ttccttttta aaagcacctg ttgctcatat 2984281 tctttgatgt cataaagcca tgcctctttt accggaacgc ccatttgctc acagtaggaa 2984341 tcccagatgg ctccgaaagg atatgttttg aattcctcca tcagggccag cctttctgta 2984401 tagcggccct cttcctgcaa ttgttttaaa tatccgttcg ggagaagcag ggcatacaat 2984461 aaagctttga tcatatttct cgttccgatg gtccaggcgg ctacacggtt aatgctggca 2984521 tcgaaaaaat ccagaccgat ggctaccttc tcaagagcat gatttcgtac aatttcaaga 2984581 gcgatttctc tcaattcatc atccaaaacc actacatggt cgctatccca acgaacaggc 2984641 cgcgatacgt gcaaggcaag cttgtctgtg taaagcagca tggacgagat cttgtttgat 2984701 accgtctcag tcggatggaa atggcctgta tcaagtaaac aaagcttatg attcgtcaaa 2984761 gcataagcta aataaaattc atgagatccg acaacatatg attcggagcc aagcccgaac 2984821 agcttgctct cgattgaatc aagattatgt tgttcactga tctcctctga gaagatccga 2984881 tccagtgatt cttttagtct tttacgcggt gtcagcctat cactcgggat atccttatag 2984941 ccgtcgggaa tccaaatatt cgtcaagcaa ggtgttccta attctttccc gaagtattcc 2985001 ccgatacggc ggcaagcgat gcaatgcctg atccaaaatt ctctgatgtc cggatcaggg 2985061 tgtgaaaggg tgagtccgtc agccgctttc tcatgcgaaa acaaggttgg attaaaatct 2985121 aaaccgagac caaggttttt tgcccatttc acccagtttt caaaatgctg cggcttcaat 2985181 tcgtcacgtt ctaccgcttc cctgtttgtt tctgcgtata tcgcatgcag gtttacgcgg 2985241 tgctttccag gaatgagaga aagagccttc tccaaatctc ttcttaattc ttcaggagtt 2985301 tgcgcttttc cgggataatt gccggtcacg tcaattccgc ctgaaagctc gcccttattt 2985361 acttcaaagc cttcaatgtc gtcaccctgc cagcagtgga tcgaaatggg cacttgctct 2985421 aattgccgaa gcgcctcttc aacatcaatt ccccattttt catatgcctg ttttgcactg 2985481 tcataattgg cttttatggt catacggctc tctcccttta tcagtttttc aatccaaata 2985541 aaaaacttcc tttagatcta tcgcaacagg actgaaatcc gaatttgttt tcattaatgg 2985601 cgccatcgat ttccaccatc tttggcaaac ttccgtgtcc gccatctttc tccatttctc 2985661 ttcatcctct atttctaaat atgcaaaaag cctgcctgtt tcctcgtcta gaaaaatgga 2985721 ataatggtgt gctccatgag ctttgagtgc ttctgccatc tcaggccaaa tgtcatcatg 2985781 ccgctgtttg tattcttcgt acttgtcttg atggacaaac atgatactgg cttttctttt 2985841 caaacctttt cacctcttca tcatttagat agcgctttca aaacagtttg ctgaaatgac 2985901 tgaatgatcg tgcttctatc aatgtcttta ggtgtaaaca ctttgatcgg aaaggaattt 2985961 ctgacgactt gccgggcttc ttttatgtct ttgacttctt tggcagcaat catttgcatc 2986021 aaaagatttc cggtggcagt tgcctctatc ggccctgcat ataccgcttt tccactcatg 2986081 tctgccgtta attgatttaa gaaatcattc cgggctccgc cgccgatgat atgaaattgc 2986141 tcgatcggtt tttctgtgat tgtttcgagc tctttgatgg ctatcgcata gatgatggct 2986201 aaattgctgt agatgcagca ggcaagttcg cctgcagtac ggggaatctt ttggcgggtt 2986261 tgtctgcaat aatgttgtat ttcctttatc atgttttctg gattcaggaa acgtttatca 2986321 tttaagttta taaattgctg gaatggttct gtttttttgg cttcttctgc aagctgctga 2986381 aaagaataat ctgcttgtag ctgctgtttg acttcttgta tcacccacat gccgataatg 2986441 tttttgagaa agcgaatggt gttgtttgcg ccgcgttcat ttgtatagtt gttttctaaa 2986501 gcaagatcag ttattatcgg tgttttgttt tcaaccccga ttaacgacca tgttccgctg 2986561 ctgatatacg cccagccatc atttacgcct ggcgccgcaa tgacggccga ggccgtatca 2986621 tgtgttgcga ctgtcatcac cttgcacgcc gggagatcat aatccgggaa ccactcattt 2986681 cttagcttcc cgagttcaca ccccggttca gtgagcggcg caaattgctg ttccagaaca 2986741 gacacggctt caagcaattc aggatcaaga tttcccgttg agacgtttaa aagctgtgtt 2986801 gtggacacgt ttgtgatttc cgttacagct tttccggtta aacaatagcc taaataatca 2986861 ggaatcatca taattttgtc tgtctttttc agcagctcac ggtcttcttc aaacaattga 2986921 tagatcgtgt tgaaaggctg aaattgtatt cctgtttttt gataaattgc ggcttttgag 2986981 agggtatgtt ccagtttgtc tattgtgtga tctgttcttc tatcacggta ggagattgct 2987041 tcccgcaacc gatcgccttt ttcgtccagt aagacataat cgactgccca tgtatcaatg 2987101 cctacggtgc agtgttcata cccaagcgtc tttacttttt gcagtccttg caggatttgt 2987161 tttagcaaat gatcaatatc ccataagcaa tgcccgtctc tttgactgaa accgttagcg 2987221 aacctgtgaa tctcttgtat gtcaagcttc ccttcattca gttcacctac catgattctc 2987281 ccgcttgatg cgcctacatc aatggcagta taaatcatcc tttcaccctc tcttcgaaag 2987341 aggaacagct gtcaccttca cctttttgtc ctcaagagct tttaccgatg ccggatcaag 2987401 tccagaatcc gtaataaggc ggctgacatc ttgcagcgag gcgatatgtg aaaactcgcg 2987461 gttcccccat ttgcttgaat cggccatcaa aatggtctgg tccgaccttt cgatcatccg 2987521 ttttttgagc agcgcctgcc actcatttga atcactcatc ccgttgtgta cgtcaaatcc 2987581 cttacatgac agaaaggttt tattgacatg ataggtctca agtgaacgct ctgctaacgg 2987641 gccggcaaat gataatgatt tttccagcaa aatgccgcct gttgaaatga ctgatatgtt 2987701 ttctttattg ctgagttcaa tagctgcttt cattgagttt gtaatcacgg tgagctcaat 2987761 gtcagggagt atttttgcca tgtaccaagc ggttgtgctt gcatcgagaa tgattcggtc 2987821 tccgcttttt acatatttgg ccgcttcgtg agcgatggct tttttttcga tgacattcgt 2987881 gatttcccgt tcagaaaaat gaatttctga ttccttctgc tgaatactga ccgctcctcc 2987941 gtggctccgg ctcagtttat gttctttttc aagcttttca agatcacgcc gaatggtttc 2988001 ctctgtgact gaaaaaatgt cacttaattc ggaaacgcgg atgcttgaac gcatatttac 2988061 tatttccact attttttgct gccgttctgc tactagcatc ggtaacgccc ttcctcatat 2988121 cgtagtccgt cttatatttt tatcatagca tatatctaac gcgtaaaagc agcagggacg 2988181 ccgccgtcta ccgtgatcat gcagcccgtt gttttttcgg ctttggaaga agcgaagaat 2988241 gcaatggctt cggcaatatc ctccgggtaa atattgacga gcaatgctgt ccgtttccgg 2988301 taatgttcct ccagctgatc cggttcaatc ccgtacgccg cggctcgttc ctcacgccag 2988361 cttgaacccc agattgccga tccttgaaga actgcatcag gcaaaacgga gttgacccta 2988421 atgccgaatt ctccgccttc tgctgcgatg catcttgcta aatgggtttc aagcgcctta 2988481 acagagctgt aggcagaggc gttttttccc gcataaactg aatttttcga tccgacaaat 2988541 accatgcttc cgcctctatt ttgatgtttc atctgtttaa acgcttcacg ggctacaagg 2988601 aaatagcctg ttcctaaaac attcatatta agattccatt cttttagact tgtttcgtca 2988661 aatgggcttg atgtggccag cccggcatta ttgacgacga tatcaatgcc gccgtaagca 2988721 agcgccgctc gttcaaaagc tgactgtacg tcttcctcct ttgtcacatc cattttgaca 2988781 gccattgccc gtccttttcc gtatgcatcg tttatttccc cggcaatttt ctgtgcgcct 2988841 tctatattca gatcagctac gatcacgtgc cctccctcag ctgcaaatcg gcggcatgcc 2988901 gcactgccga ttccgccggc tcctccagtt atcagcgcta cttttcggga aaattctgct 2988961 tccggcgggg ccagcgtgag tttatatagt tcgagcggcc aatattcgac atggtaggac 2989021 tcattttcat gtaaagaaac aaattgcccc agagcggttg ctcctttcat tacggcgatg 2989081 gccctccgat ataaagcccc gcttacttta gacatcgcat aactttttcc tgtattcacc 2989141 attccgattc caggaatcaa tatcacccgc ggggcggatt caaagatttg atccccatcc 2989201 tgctgattgc gtgtaaagta agcctgatac tctgatgtaa aggtctcgac tcctgacttg 2989261 atcagatctg caagcttgtg cacatcttga gtttccggat tccaatcaat gtacagcgga 2989321 acccgttttg tgtgaacaag gtgatccggg catgccgcac cgatttgcga aagtgctggc 2989381 gcttggacac tgtttacaaa ttccaagaca tcgtcatgat catcatagga aaggatcatt 2989441 ttcttttctt cacttactgc tcctctgatc acaggcatga tgcctgccaa gatttgtttt 2989501 cttttatcct ccggcagcgg ctgatacctt ttgcctccga atacctcatg ctgattgata 2989561 cgatcgttaa tatactgctc ggcttcttga atgatggata tcgttttttg ataacatgtt 2989621 tcagacgtct ctccccaagt gactaagccg tgtttctcca ttaatacaag ctcggcgtgg 2989681 gggttgtttg ctacgccttc agcgatcatt ttagacaaag taaatccagg acggacgtat 2989741 ggcacccata caaaccgatt tccgtaaatg tcttcagcga tttgttttcc attatccgca 2989801 cagcatatgc tgataatcgc atctggatgg gtatggtcaa catgtttgta tggcagaaaa 2989861 gcgtgtaata gcgtttcaat tgaagggcgg ggatgtttgc tgtctatcat acaatgagac 2989921 aggtagtcta ccatttcttc atcgggcatt tggtcccttt taatcagcgg gcggatatca 2989981 tctaatttca aaccggaaaa gttatgcgct ttcattgttg ccaaatccga tccgcttcct 2990041 tttacccaca tgacttctat ttcacggcct ctaaaatcct tttccgttgt tttcatagat 2990101 gtattccccc cgccccagtt gcagacagtg cggtctgacc cgatcagatt ggacctgtac 2990161 accaattcct ctacaccttt aggtagctgt gcagctcgct ctgaatccca tatatgtttc 2990221 accatatttg atattcctcc ataccctttt atttgtatcc gttttcatta tatatgattt 2990281 ctgtttgttt ttgaatcgtt tttgtttatt tttgcttttt aacaaaaaaa gaaagcagca 2990341 gatatgccgc tttctcgttt cattatgatt ctattttaaa tttcttcgta atgtcctgaa 2990401 gttcttccgc catgtttgcc aacgtttccg ctgaagagct gatttcttcc atggacgcaa 2990461 gctgttcttc cgccgaagct gcgatatcct gaatgcctgc tgagctttct ttcgccactg 2990521 cagaaatatc ttcaacagca cttgacactt cctgtgatcc ggctgacagt tgttcaaccg 2990581 tcgcgttcaa gttttgcaat tcgccggaaa tttgggttgt catctcatag atttgtttaa 2990641 agctttccgc tgtttgatcc gtaatctgca agccttcttt cacttcatga ttcacggatt 2990701 ggaacattga aagtgaggtg ctgatttccc tgacaatctc ttgaattaat ccttcaattt 2990761 ccttggcgga gtctgctgat tgtacagcaa gttttctaac ctcttccgca actactgaga 2990821 aacctcttcc gtattctccc gctcttgccg cctcaatcgc agcatttaat gcaagcaggt 2990881 tggtttgatc agcaatgccg ttaatcacat tcaagatgct tgtgatgtct tgcgattttg 2990941 tttcaaggcc cttcacaacc gcttccgctt tttgaacgga ttggtcaatt gttttcatct 2991001 ggccgactgt atgctccacc agcttttctc cgctgcccgc tgcctcagag gactgaatcg 2991061 atgatttcgt aatggttgaa gaggcttgag ccacttttga aatcccctcg ttcatttgag 2991121 aaagatgatt tgagcttgtt tccagtttct cgctttgtgc ctcgttgcca tctgagaact 2991181 gttcgatggc aagtgtaata tgttcagttg ccttgcttgt ttgggctgcg cttgctgtca 2991241 gctcctcaga agatgaagcg acgttttcta cagacgtttg aataacgcct attacagaac 2991301 gcaatgatgc agacatttca ttaaagcttt cgccaagctg gccaaactcg tttttcgagt 2991361 gaatgtcaat gacttctgtg agatctccgc tgctgatttt tgcagacgtt gagacaagtt 2991421 ttcttaacgg cttggtgatg gcacggataa tatagagtat gagtatgccg ccgattacta 2991481 ttgacacgca tagaatgata accgcagtgt tcagcaccgg gcttgaagca tcttgcaatt 2991541 cactgacaaa atatgtgccc gcgattttcc agccagtcag tttatttgtc gtaaaggcca 2991601 ttttcttttc tttgccttcg aatgtatatt caaatgagcc ttcttttttg gaatatactt 2991661 ggtttgtcca atcgccggaa ccggttgtcc ccggcttaat ggtcggatgg gcgatatatt 2991721 ttttgttgcc tgtcgtaata aatgcaaagc cttcttttcc gattttgatt ctttttgatg 2991781 cagtaagcac ttcatccagg tttaaatcta gcgctataac ccctgaaccg tcttttaatt 2991841 gttttgaaat tgtgacaacg atatctcctg tcgcttcatc ggtatacggt tctgagaaaa 2991901 cagcttgtcc tttttccgca accgcctgtt tgtaccagtc acgtcctgtc ggatcgaaac 2991961 ctttcggaac accgctatcc ggatatttat aaagcttctt atcttctgag gcagcataga 2992021 ttgcgcctac atcgtcgtta agtgtcgtgt actgcttaaa tttctctttc agtaatgttt 2992081 tgtttttgcc taacaatatg tctttatcga ctgtctcact ataataatct attgctttta 2992141 ctttatcttc taatttattt tgcagcgtac tgtttagttc ttcaacattt cccttcgcac 2992201 tgcttatgag ctctctgtct aacgcgttcc aagctgattg ataactgaaa tatgctaaaa 2992261 ccccaaccgg caaaataagc actgccagaa acgcagcgat tagcggtttg ctgatcgatg 2992321 gctgtttgat ccattgtatg aattttccca ttctcgttga ctcctccttt aagataaatc 2992381 taatatcgtc aaactaggat aaaaggttta ataaaaaaac taaaaaaaac acccaagcgc 2992441 aacaagcttg ggtgttaagg cttattattc aattttaaat cgtttggtca tatcccgaag 2992501 ctcttccgcc atagaggaaa gggtctctgc agacgagctg atttcttcca tggaagctag 2992561 ctgctcttca gctgacgccg cgatatcttg tatatgcgct gagctttctt ttgaaatcga 2992621 tgcaatgtgc tcagacgctc ccgaaacttc ttcggagctg gcagaaagct gctgaaccgt 2992681 cgcactcata ttttgcagtt cgccggcgat ttggttcgtc atttcagaaa tgcgtttgaa 2992741 gctcatttct gttttatctg tgatgtcaag tcctgtctgc acctcttgat tgacagattg 2992801 gaacatgccg agtgatgtat tgatttcctt cacaatttcg atgattaatc cttcaatctc 2992861 ttttgctgaa tctgctgact gtactgccag ttttcttact tcttccgcta caacggagaa 2992921 gccgcggccg tactcgcctg cgcgcgctgc ttcaattgct gcgtttaagg caagcaggtt 2992981 cgtctggtct gcgatgccgt tgatcacacg caaaatgttt gtaatatctt tcgatttcgt 2993041 ttccaatccg cgtacgactt gctccgcttc tttaacggac ttgtcaatga cattcatttg 2993101 gccgacggtt tgatgaacaa gcttgccgcc ttcacttgca atttctgtcg attgaacaga 2993161 tgaatcagtg atcacttcag aagcttgagc catattcgtc aacccgtcat tcatttgata 2993221 aatgtgctct gctgccgttt caatgttttc gttttgtttt tcattgccgt tagaaaattg 2993281 ttcaatcgcc aatgtaatgt gctctgttgc cttgctcgtt tgcgcagctg atgcagtcag 2993341 ctcctcagag gaagcggcaa cattgtctac cgaatcctgg atggcgtgta tgagagaacg 2993401 aagtgacgac gccatattgt taaagctttt gccgagctcg cccaattcat cttttgaacg 2993461 gatatcaatg gtttccgtca aatctccctc gctgatccgc ttagaggaac cgacaagctg 2993521 tttcagcggt gttgtaatcg accgaatgat caatgtcatg acgataatcc ctatgataat 2993581 agctgcggcc aagacaatta aagcaaggtg aaggacaggc tgggctgcct catggatttc 2993641 atccaaatac atggtgccgc cgatcttcca tcccgtcaac ttgtttgtgt caaaggccat 2993701 ttttttctta tcgccatcca tggtgtattg aaaatcgcct ttatcagcac tcaacatctt 2993761 atcgagccag tcgcctttta attcagttcc tgattgttca ttagggtgtg cgacaacttt 2993821 tttgtccttc gtcatgataa atgcgtagcc ttgtgtgccg atgttgactt ttttggttgt 2993881 tttcagcaga ttttcaatcg tcatgttgat tgcgataacg cctgaaccat cttttgtctg 2993941 ctgggcgatt gtcacaacca tcgtatttgt cgacgcggtt ttataagggt ctgtgatcac 2994001 gactttccct ttatttgcaa ccgctttttt gtaccagtcg cgttcaaccg gattatagcc 2994061 gcttggcatc ggaagatccg gatagcgggt aaagtgccct tttgtgtcac ttgtataaat 2994121 ggattctaca tccttgttaa tgctgatata ttgtgagaat ttctctgcaa tgcttgcatt 2994181 gctttttgca ttgtatttct cttttgtcag ccattcgctg aaataatcag cactgttttc 2994241 tttttcgccg atgctggtgt taatgatttc gtttaattgc tgtacatttt ccaatgcgct 2994301 ccccatcatc tgtctgtcga gtgagctgct agccgattga tacgcaaaga tcgccaatat 2994361 gacaaccggt atgatgagga tcgacagaaa ggaaacgaga agcttccgtg taattgatct 2994421 ttgttttatg agttggagta tttttttcat cattcatttc tcctttttta tgctaccctt 2994481 catatcggct ggaaatgggt aaatatatac agcaaaaaag aagaaattta acaaaagtaa 2994541 ctaatttccc ataaataaat agtattttag acctattatt tgtctacttt aaattgtttt 2994601 gtcagatcac ggagttcttc agacattctt tcaagcgtca gtgcagatga actaatctcc 2994661 tccatggatg ccagctgttc ctcagctgaa gcggcgatat cttggatgcc atccgagctt 2994721 tccttagaaa tggcagtgat atcatttgaa gctgcggaaa tttcttgagc tcccgctgac 2994781 agctcctcaa ccgtcgcatt catgttttgc agctcggaag caatttgatt ggtcatttgc 2994841 gatatatgtt tgaagctctg tttagtttca tccgtcatga caagccctgt ttcaacttct 2994901 ttgtttacgg actgaagcac gttcagtgat gtgtgaattt cttttactat ttcactgatc 2994961 agcgattcaa tttcttttgc tgagtcagcc gactgtaccg cgagctttct cacttcctca 2995021 gcgacgactg agaagccccg gccgtattca cccgctctgg cagcttcaat ggcggcattt 2995081 aaagccaaaa gattggtttg atccgcaatg ccgttgatga cacgcaaaat attcgtgata 2995141 tcctttgatt tgatctccag ccctttcacc acttgttccg ctgcttttac ggaatggtca 2995201 attgtgttca tttggccggc tgttttctgg acgagtgtct cccctttgct tgacacttcg 2995261 gttgaatctg cggatgtttc tgtaatcact gctgcagccc gcgccagctc tgccaatccg 2995321 tcattcattt cattaatttg ttcggttgtc gtttctattt tctcgctttg gctttcactg 2995381 ccgtttgaaa attgctcgat agccatcgta atgtgctcag tggctctgct tgtctggtct 2995441 gccgatgcag tcagctcttc agacgaggag gcaacgtgtt ctactgagtc tttgatcccg 2995501 tgaatgagcg agcgaagcga gtgtgccata tgattgaagc tctcactcag aacgccgagt 2995561 tcatcttttg aattgatttc aatcgtttcg gttagatcgc cttcactaat tttttcagcg 2995621 gatgcgacaa tgcgtctcaa tggctttgtg atggatcgaa tcacaaaata aatcgccgtc 2995681 attccagctc cgatggcaat cgccagaacg attgaagcca tgatcagaac cctgcttgca 2995741 gcatcgtgaa tctcgtttgc atacatcgtg ccgctgattt tccagcctgt tgtttggctt 2995801 gttgcaaatg ccattttttt ctttttgcct ttgtacgtat attcaaagtc cccgctttta 2995861 tccttgtaga gcttatcaac ccagtcccct tttagctctg ttcccgcttt ttctccggag 2995921 taggcgatga ctttcttgtt ttggctcaaa ataaaagcat agccttcttt tccgatattg 2995981 attcctttcg cggtagtgac taagtcatca attttcatat caatggcgac aacgcctgac 2996041 ccatccaccg tttgacgggc gatggtgacg accatttttc ctgatgaaat cgattcataa 2996101 ggctcagtga caattgtttt gcctttattg gccattgctt ctttgtacca atctcgttcc 2996161 aaagcattaa agtcgcttgg catgtcagcg tacggataac gtgtgaagtc cccgtctttg 2996221 ccgcttgaaa ataccgcagc gacattatca ttcatttgga taaattgttt aaattcctgt 2996281 ttcagctctg ttttcttttt atcctgaaat ttttctgctg tagcccaatc gctgaaatat 2996341 gcgaggcttt tttcagtagt gctgatttta tcatcaatga tgtgatctaa tatctgaaca 2996401 ttttcctttg cgctttgcgt catctgtaca tcaagtgagg caactgctga ttgataagcg 2996461 ctaaccgaaa gggcggttat cggaacaatt aagatcagca ggaaagaaat aataagtctc 2996521 cttgcaattg atgatctgcg aatagtggtg agtgtttttt tcatttcctt ttgaaccttc 2996581 tttcaataat ttacaaatta tatcggcgga tcttccttta aattacattg aaaatggagg 2996641 aaaaaatgaa aaatagttct aaattcacct gttaaactag gactttatta ttgtttacca 2996701 tataaaaaaa cagcgctttg atagcgctgt ttttcggttt ttactcgatt ttaaattgtt 2996761 tcgtcagatc gcgaagctct tctgccatct gcgcaagagt cgtcgctgag gaactgattt 2996821 cttccatgga agcaagctgt tcttcagctg atgcggcaat gtcctggatg cttgccgagc 2996881 tttctttcga cacgtctgca atgccgctga ctgctgctga aacatgctgt gaacggtctg 2996941 acagctgctc gacggtggaa ttcatcgtct gcagcttgcc cgcgatttcg tttgtcatgc 2997001 tgaaaatgct ctggaagctt tcttttgtat tgtctgtgac aacaagtccg gactgtactt 2997061 cctgattgac ctctttaaac atgtgaagag aggtgtcgat ttctgcgacg atttcttgga 2997121 tcagcttttc gatttctttc gctgaatcgg ctgattggac agccagcttg cgcacctcct 2997181 ccgctacgac agagaagccg cgtcctgact ctccggcacg cgccgcttca atggctgcat 2997241 ttagtgcaag cagatttgtt tggtcagcga ttccgttgat gactctcaaa atgcttgtga 2997301 tgtcttttga ttttccttct aagcctttga caacagcttc agcctgctga acagattgat 2997361 taatcgagtt catttgtccg actgtctgct gcacaaactt ctcacccgtt ccggcgattt 2997421 ccgttgattg gatagatgcc tttgtaatat ctgacgatgt ttgtgagact tgctggagtc 2997481 cttcattcat taagttcagc tgatgagagc tggattcaac cttttcgctt tgctcctcgt 2997541 ttccgtttga gaactgctca atcgccatcg taatatgctc ggtggcttta ctcgtctgcc 2997601 cggcagatgc ggtaagctgt tcggaagatg cggccacatt gttcaccgag tcctgaatag 2997661 cgctgatcag agagcggaga gattgtccca tttcattgaa gctttcccca agctctccaa 2997721 gctcatcctt tgaatggatt tcgatcgttt cggtcagatc ccccctgctg atcgttttcg 2997781 atgattgaac aagacgtttt aacggttttg taatcgaacg aacgataaac agaattaaaa 2997841 ttccgcctgc cacaatggaa gcaatcagca caatcattcc tgttgtcagc acagactttg 2997901 aggcatcctt aatttcatcc atatacattg tgccggctat tttccaacca gtcagttcgt 2997961 ttgtagtata ggtcatcttt ttatcttcgt tattaagagt atactggagt tcaccgctgt 2998021 cattcgcata cattttggct acccagtcgc ctgaaagctt ttctccagcc ttatggttct 2998081 tgtgggcgac ataggttttg ttttttgttg caatgaaagc ataaccttct tttccgacct 2998141 tgatttgttt catttgttct aacaatttat caatggtaat atccatggcg acaacgccag 2998201 atccgtcctt cagctcctgt gcaatggtaa tgaccatgct tccgtcactc gcagccacgt 2998261 aaggatctgt cacgacaatt tcaccgccgg ccttcatcgc atcctggtac caaggccgtt 2998321 gtctcgggtc gtatccttcc ggcaattttt cttttggcgc ttgtacataa gtgccgttat 2998381 ctgcgccccc ataaattctg gctactcctt gattaataga tacatattgt gaaaatttag 2998441 ctttgatctc ttcttgattt gatttccctt tgaatgcgga tcttttaaga gattcactga 2998501 aaaaggtgac tgctttcgct ttttctccca gatcatttgt aacagttgta ttaaatgtat 2998561 cgacactgtt tttcgcattt cccataattt cctgatccag ctttccgctg gcgcttcggt 2998621 aagagctaaa ttctaatata agaataggga taatgagaat cgcaataaat gagacgatta 2998681 atttctttga aatagacggt ttcttcagcc aattgataaa agtcttcatg tcacttgctc 2998741 cttcaggttt gatacagtat atatcggctg cttaaaaaag ttttaaaata aaaaatggaa 2998801 gaagttcttt ttggctgtct tctgcctttt taactttcat tgcccaagct ctttgcatat 2998861 cttataaaaa acaagggggg ctaaacatga ttattgtatc aggacaattg ctccgtcccc 2998921 aggatattga aaattggcag attgatcaag atctgaatcc gctcttaaaa gagatgattg 2998981 agacgcctgt tcagtttgat tatcattcaa ttgctgaact gatgtttgag cttaaactgc 2999041 ggatgaatat tgtagcagcg gcaaagacgc tgcacaaaag cggggcgaag tttgccactt 2999101 ttttaaaaac atacgggaat acaacgtatt ggagggtttc accggagggc gccttggagc 2999161 tgaaatacag aatgccgcct tcaaaagcga ttcgggacat tgcagagaac ggcccgtttt 2999221 atgcgtttga atgcgcaacc gcaatcgtta tcatttatta cttggcctta atcgatacaa 2999281 tcggagaaga taaattcaat gccagctttg acagaattat tttatatgac tggcattatg 2999341 agaaattgcc gatatatacg gaaacaggac accacttttt ccttggagat tgtttgtatt 2999401 ttaagaatcc tgaatttgat ccgcaaaagg cgcaatggag aggcgaaaat gtgatactac 2999461 tgggggaaga taaatatttt gcccatggtc ttggaatctt aaacggaaag caaattattg 2999521 ataagctgaa ttcttttagg aaaaaaggag ccttacagtc agcctacctt ctgtctcagg 2999581 cgaccagact ggatgttccg tctcttttcc gcatcgtccg ctaaaaagcc ccatcgccta 2999641 ttttccggac gatggggttt caaatgcctt tcgttttcga tagaaggggg ctgtgccaaa 2999701 atattggttc gcagcccact ccattttttc aaggtcattt cttgtcacga ttggatcctg 2999761 gctgctccat ttgataaagc ggacaaaata gtagcctttg ataggaacca ttgtaacttt 2999821 tgagtgaggc cagccttcaa atacaaactc aattttccct ctttttttat aagaatattg 2999881 aagaatgttc atatctgtca cctcagttta tcaagttacg ttcggcaaag ctcggtacgt 2999941 ttacatccat tgattaacta tccctcatgc aggctttccg gaaaacaaag ggtgaggcgc 3000001 gtgtctcttt ccctcgcttt ttatttcgca tatggacgaa tgccaagcac gccttcattc 3000061 gataaagccg cagcgtgggc gggtgtgaca agccctccgg ctatcggcgc ttgttcagcg 3000121 atcatgcttt tgtcataaaa aacagcctat tatcccatca ttttgatata gcatgtccgg 3000181 gtgcgaggcc cgtcaaattc gcagaaataa atgccctgcc acgttccaag aataagccgg 3000241 ccgttttcca caatgacatg ctgtgaagct ccgaccgtac tcgacttcat gtgtgcagct 3000301 gtattgccct ccatatggcg gtccagctca tgttcccacg gatatacctc atcaaacctt 3000361 ctgagcatat cttttttgac gtccggatcg gcattttcat taattgtaat gcccgcagtc 3000421 gtatgcggac agtaaatcag cgctgcgccg ctcgttatac ctgtttcttg aagaaacgct 3000481 tccacctccc gggtgatatc tatcatttca tctcgtttgg ttgttttgat ttgcagtgtt 3000541 ttcagcattt gtttctcctt tcgtttgtcc gctctcatcg cttaattcgt tctgtgttct 3000601 tttttttcct gttaaaccgc tctcataaac ccgataaaac aaaaaaactc cagtctaagg 3000661 ctggagttta gcaccataga tatattcttg cttcatacgg ctttaagagt actgatgtca 3000721 tatgcttgtg cggctctgtt tcaatatttg acaagacgag tgcatctgat gacaatggca 3000781 atccagagtg cctgaacaac gccggtgttc ctgtcagatt ggccgcaatc agtgcagtat 3000841 ggctctcgtt tttccgaaga tatgcaaaga tttgctgatc ttccggtaaa atgagctcgt 3000901 atgtcccgtt aataaaaaca tcatatgttt ggcgcagctt gatcaagctt ttgtaaaaat 3000961 ggtaaacgga tgttttatcg tttttttgcg cctcggcatt cagccatttg taattctcat 3001021 tgattccgat ccacggtttg gcctcagaaa atccggcgta tggaccagca ttccattgca 3001081 tcggcgttcg cgaattgtct cttccctttt tccagacaat cttcatcaca tcctcgtgtg 3001141 atgtgccttt cgctgttttt gtttcataca ggcgtttcaa tgcgacatca tcatagtcct 3001201 caatagatgg aaaagccacg ttcgtcatcc cgagttcctg tccctgataa ataaacggtg 3001261 tgcctttcat gagaaaataa acagcggaaa gcgcttttgc actttctttc aggtacactc 3001321 cgtcgtctcc ccacacagaa actgaacggg gctggtcgtg attctccata aacaaagcat 3001381 tccagccgat cccttccaga ctgtcctgcc agtcagttaa aattcgttta aatgcaacga 3001441 tatcaatact ttcattgatc tctacatccc acaggccgag atgctcaaat tgaaaaatca 3001501 tgctgaatat gccgtttttt tctccagccc aatcagctgc ttcttttgca gcgacgccgt 3001561 ttgcttcacc aactgtcata atcggatagc gggaaaatgt gttttccttc agctctgtta 3001621 acaaatccat aatgccgtca gcattcatat gataaggaaa ggaagggaca tagtccagtc 3001681 cctttggatt cggcatgtca ggaaaccctt cttttttctt aatatgcgta atggcatcca 3001741 cccgaaatcc gtcaattcct ttatcaagcc accaattgat catgtcataa acggcattcc 3001801 tcaccttttc attttcccaa ttcaaatcag gctgtttttt atcaaaaagg tgcagataat 3001861 actggcttgt cttttgatca tactcccaag ccggcccgcc gaaaatgctt tcccaattgt 3001921 tgggcgtttt tccgtttttg ccgtctttcc aaatatacca gtcgcgcttt tccgagtgta 3001981 tggatgaacg ggattctatg aaccatggat gttcgtcgct tgtgtggttc acaacgagat 3002041 ccataatcag cttcatatcc agatcatgaa tgtcaccaag cagctcatca aaatcttcca 3002101 tcgtgccaaa ctcgcttaat atgttttgat aatccctgat atcatagcca ttatcggcat 3002161 tcggtgaatc atacagcggg caaatccata tgacgtcagc gcccagctct tttatgtaag 3002221 aaagcttggt tctgattcct tgaatatccc cgattccgtc gccatttgaa tctttaaaac 3002281 tgcgggggta aatttggtaa actacggctt ccttccacca agcctttttc atacagccac 3002341 tccttcccag tgtaccgttc ttatatatcc tatgtagaaa aaggtcttta cagcattgct 3002401 ttttaagaaa tgacttgatg acacaaaaaa cagccgtttg ttccccggct gttttttatc 3002461 aaaaatcagt tttttttatt tctacaaaac ggatgtggtg atcttcggcg tcgaggattt 3002521 taaattcaca gccctccgcg tgtatcacat cccctgcttt cagctccatt ttttgcgtta 3002581 gaagccagcc tgcaatcgta tcaatttctt cattttcaat cgcaatgtcg agaaggtcat 3002641 tcacttcgtc tattagcgct tttccatcca tcacataatg gtgctcgccc tttttcagga 3002701 tgtgcggtgt ttcatcctga tcatactcat cgcggatttc cccgacgatt tcctcgataa 3002761 tatcctctac agtgacaagc cccgccgttc ccccgtattc atcgacaaga atcgccatgt 3002821 gaatccgctc cttctgcatg cggattaaaa gctgctgaac aggaatgctt tcaatgactc 3002881 tgataacggg cctcatgatt tgattcagct ttatcggctg gccgagaaaa taagctttaa 3002941 acatatcttt gctgttgatg atccctaaaa tatgatcctt gtcatctttg atgacagggt 3003001 agcgtgtata ccgttcatta atgatgtgat gaattgcctc ttcaagcgac tgctccagag 3003061 agataaccgc aatttctgtc cgcggaatca taatctctct cgctacccgg ttgtcaaatt 3003121 caaaaatctt atttacatag cggaattcag actgattgat ttctcccttt tcatagcttt 3003181 cagaaaggat cagccttagt tcctcttcgc tgatgacaac ctgatgctcc tttaccgaat 3003241 gaaagccaaa caatttcaca agaaaacttg cagagccgtt taatgcttta ataaacgggt 3003301 acgtgatttt ataaaaccag atcagcggct ttgcaatcca taagcttaca gcttcagctt 3003361 tttgaataga aaccgttttc ggggcaagct cccccatcac cacatgcaaa aaagtgacga 3003421 tgataaatgc aactacaaat gtgacaatgt ggttaaacgg ttccggtatg cctgtcattg 3003481 taaataaggg atgaagaaaa cgttcaaatg taggttcacc aagccaccca aggccgaggg 3003541 ctgtaatcgt aatcccgagc tggcaggctg ataaatactc gtcaagattg gagatgattt 3003601 tatgtgcggc tagtgctcgg ctgtcaccgc tttcgatgag ctgattgatt tttgaacctc 3003661 tgattttgac gatcgcaaat tccgctgcaa cgaaaacagc cgtaatgcca atcaaaacaa 3003721 aaatggcgat caattgtaaa ataagcaaaa aaagccctta ccataaatgg taaggggcca 3003781 cctccttaac gttaattctc atcacgaccg tttaagaaaa tcatcacaaa acgaagtagt 3003841 tcaaacaggg aaaccagggc ggcggccaca tacgttaagg cagcagcact cagcacttta 3003901 tttaccccat tttcttcatt gtttcggatg aatccttctg acacaataat ctgcttcgca 3003961 cgtgaacttg cattgaattc gacaggcaat gtaatcagct ggaaaaagac agccgctgaa 3004021 aacagtatga tgccaagccc gatcaaattc aggctgccga gaagcatgcc tcctaagaaa 3004081 agcaaaggag ctacaccgga tgcaaaattc acgactggga agattttatg tctcagcaca 3004141 agcgcaccat atgactcctg atgctgcaag gcatgtccga cttcatggga agctacggat 3004201 atggcggaaa ttgagcggcc gtaatagacc ggctcagata aacgcaccac ccgtcttgtc 3004261 gggtcgtaat ggtctgttaa agtgcctctt accggttcga ccggcacgtc gtaaagaccg 3004321 tttatatcta aaatccgtct tgccgtttct gcccctgtac gtccgcttga ggcttccact 3004381 tttgaatatt tttcaaagtt gctctttact ttaaattgtg cccaaaacga caatcccaat 3004441 gcggctattg ttaaaaatat aaacagcatt ttttcatcat cctttgttca tgatcatttc 3004501 tctattacga ttattttaat gagttttctt tctcgtgtac agaaatgcgc tttttcttcc 3004561 ggcttggagc acacaatcca atcagcaaaa agaacaggcc tgctgaaaac aaataaaagg 3004621 cgaaactgcc ggccagttct ttcagaaaat gaagccagga gaagcttccg gaaaagtgat 3004681 tatatgaatt caaatcgaaa ataaacaaaa tcaccgcgga tgccgccagc tgcgtaccga 3004741 ttaaaaccac gatcgttctt tgaaagatcg tcatcttttt catccttttt gttttagttt 3004801 atggagaaat ccggttttat atgttttgta cattttttga aaaacatcac cggaagtggg 3004861 acatactgtt agaaaaaagc acgggtgtga tggaagctat gaaagtgacg agtgaggaaa 3004921 aggaacagct gagcacagca atcgaccgaa tgaatgaagg actggacgcg tttatccagc 3004981 tgtataatga atcggaaatt gatgaaccgc ttattcagct tgatgatgat acagccgagt 3005041 taatgaagca ggcccgagat atgtacggcc aggaaaagct aaatgagaaa ttaaatacaa 3005101 ttattaaaca gattttatcc atctcagtat ctgaagaagg agaaaaagaa tgaaatcaaa 3005161 tcggatattt atttcatggc tcaggtggcc gttatttatc cgaatcgggg ttattatttt 3005221 atgtctgatt cttttgttcg gccaaatcat ttatatactt gagcctaagc agttcacttc 3005281 ggtattcgaa ggtatttggt gggctgtcgt tacggtttct acagtcggtt atggagacta 3005341 tgtgccgcac actccgctgg gacaggcagc cggaatactg ctgattttga gcggagcaag 3005401 ctttgtcaca gcgtatttcg ctacgttatc agcggccgca ttcagcagac agcatcgcta 3005461 cattgaagga aaagttgctt acaaaggccg ggaccacatc attctgatcg ggtggaatga 3005521 aaaaacaaac cggcttttga aggaccttca gcttgccgcc ccttccaaaa cagtcgtact 3005581 aatcgatgaa tccttaacag aaggcccgct tattgaaaac gttcatttca tacgcgggca 3005641 cgctgccgat gatgggacac tgaaacgggc caatattact gaagcggaat cagtgatgat 3005701 tactgccgat cagtataaaa gtgaaactga tgctgatatg ctgtcagtgc tgactctttt 3005761 atctgttaaa ggtcttaatc cccttgctta ctgcatcgtc gagattttaa ctgaccgttt 3005821 tgtcaccaat gcggaacggg caggcgcaaa ccaaatcatc ggaacttcag aatttatcag 3005881 ccgggcgatg ctgcagcatt accaagtcaa gttacggccg tctaaacagc agaacggaat 3005941 caagctgaca cttgatcagc atgtggagct tcttgctgtt cctgacgaac taaagggagc 3006001 ggcttacaaa acctgtgttc tctatttcct tgatcacaac acaacaatta taggcataca 3006061 aaaaaaggag gggccgatgc tttcccctcc tcttacatac aaggtgctcg aaacagatca 3006121 attccttgcc atctagtgta acagaacatc ctccaattct ttcacgagag aggcgccgat 3006181 atccaaaaat gccggatcaa tttccgcgtc ccgcctttcc ggttcggaaa attgattaaa 3006241 cagtgattgg aaaggccctc cctcggcgtg atcgtcaaca tccgcctgaa acacctgtct 3006301 cagcataaat ggcgttccga tccggacggc cgcccctcgt tcatcgagac tgccctgtac 3006361 cgcattgacg ggaattctta aaaataaata gccgtctcta tcatcaattt tataatcaaa 3006421 gtagccatga tcgtattccc agccgccgtt tatcacataa ccgagcggct tcatcacttg 3006481 ttccagttct tgaagcagaa aagactgccc atctatcgcg gaaggtattg gtatcatcag 3006541 aatgcccctt ttttcactta tcctgtcccg ccgaacaaga cttcattcag aggcgcctac 3006601 atggaaatcg ttgtttcttt cgcgcggcca acaggaaaga aagcgcattc aattaagaag 3006661 taaacagcca ttgccgctgc aagccataca gctgaatccc aagacacata aacaaccgtt 3006721 gcatagagtc ctaatttagt gaaaagagta tgggttcgtt ttaaatgcaa aatccgatgt 3006781 accgcatcgg taaaaagggc aagcggcaaa ccaatgagaa gaaaggagtg gatgaaaaaa 3006841 tgtgacagcg tgccgccaaa gcttgaagaa aaccctgtat acacggcatc aaaggagata 3006901 aggaaactta aaatagctgc agaaaaaccg gcaatgatga gatgtttaac caattgtttc 3006961 atgaacatca gcacctttct gattttataa aaagccgacc ggcaaatgcc agtcagcttt 3007021 ctcacattaa tcttccagac gtttttcaag ctctgctttt ttctcttcaa agccaggttt 3007081 gccgagtaac gcaaacatat tgactttata cgcttctaca ccaggctggt caaacggatt 3007141 gacgccaagg aggtaaccgc tcatcgcgca ggctttttcg aagaaatata caaggtatcc 3007201 aaaagtatat gcattcagct caggaatgtt aacgattaag ttcggaacat ttccgtctgt 3007261 atgggcaagc attgtacctt ggaatgcttt tttgttaacg aaatcaacag ttttaccggc 3007321 taaatagttc aagccgtcaa gatcgttatc cgcttcctca attgtcagtt catgtttagg 3007381 cttctctacg ttcaggaccg tttcgaataa atctctgcgg ccttcttgta catactggcc 3007441 taaagaatga aggtctgttg aatagttcgc tgaagaagga taaatgccct tctcatcttt 3007501 cccttcgctt tctccgaaca gctgcttcca ccattccgca aagtattgaa gcgccggttc 3007561 gtagttgatg agcatttcaa ttgttttgcc cttattataa aggacattgc gaacaaccgc 3007621 atattggtat gctgggttat cttccagttc agatgttgca aaatctttgc tcgcatccag 3007681 ggcgcctttc atcatgtcgt caatgttgac gccgctgaca gcaatcggca agagacctac 3007741 agctgttaaa actgaataac ggccgccgac atcgtcagga attacgaatg attcaaagcc 3007801 ttcttcgtta gaaagcgttt ttaatgcgcc gcgctcttta tcagttgttg cataaatccg 3007861 cgctttcgct tcttctttac cgtatttctc ttcaagaagc ttgcggaaaa tacggaaagc 3007921 gattgcaggt tcagttgtcg tacctgattt agaaatcaca ttaatagaga agtcaacatc 3007981 ttcaagaaga tccatgacgt ctctcatata agatgaactg atgttgttcc cgataaaaat 3008041 gacttgcgga ttgccgcgtt ttgcttttgg caaagtgtta taaaacgcgt gattcagcgc 3008101 ttcaatcgct gcccgcgctc caagataaga accgccgatg ccgacaacaa gcaagacatc 3008161 agagtcagat ttgatttttt ccgcgctttt tttgatgcgc gcgaattctt ctttatcata 3008221 atgttcaggg aggtccaccc agcctagaaa atcgctgccc gcgcctgttt tctcatggat 3008281 attatggtgt gctgttttta caaagtcccg caggtatgta agttcatgtt cgttgaagaa 3008341 agtcaacgct tttgagtagt caaagcgtac atgcgtcatt gcttgtccct ccataacggt 3008401 ataatgtttt catctttcac tttatatgaa cttatctgtg aaatcaagtc aagaagaaag 3008461 ggcggaatga ctggattccg ccctttgggt ttatagagac gcgcgaagga tggcaagcac 3008521 gtcatctttg ttcagttttt ggaagttgcc gaagccgccg tgttccattt ccttggctgc 3008581 gatatcagca atcagctcaa gcttttcttc tccaatattg taatcagcaa gacgagaagg 3008641 tgcaccgagg cttgtccaga acgcagacag tttatcgatt ccttcaagcg caatttcttt 3008701 atctgttttg ccttcagtat caatgtcaaa catgttgagc ataaggtttt taaaacggcc 3008761 tacatttgta tcaagcgtgt atctcatcca atttgggaac agtattgcca aaccgcccgc 3008821 gtgcggaata tcatatacag ctgaaacagc gtgttccatt gtatgagaag cccagtcacc 3008881 gaagtatccc atttggagcg tgccgtttaa agcaatagta ccagcataca aaatcgtttc 3008941 acgaagttcg tagttttcca gatcttcaag aagcttagga gctgtttcga tgaccgtctg 3009001 caaaacagca aagcacattc tatcctgaag cggcgtgttt tcaacattat ggaagtattg 3009061 ttcgaatacg tggctcatca tgtcaaccat gccgtatact gtttgatttt ctggaacggt 3009121 gaacgtattt tcagggtcta aaatagagaa acgcggatga gtgacattgc tgccccatac 3009181 aaatttctcg tttgtttccc agtttgtaat cacggaatca gggttcattt cagaccctgt 3009241 tgcagcaaga gttaaaacag tgccaaacgg cagcgcatcc tccgctgtta cttttttgct 3009301 gaaaatatcc caagcgtcac cgtcatattt gacgccagct gcgattgcct ttgtacagtc 3009361 aatcacactg cctccgccga cagcaagcag aaaatcaatg tcatgctctc tgcaaagtcc 3009421 tatgcctttt tccactgtcg caagacgcgg gtttggctct acacctgaca gctcatgaac 3009481 aacagcgccc tcttctttta aaatgcctgt gacttgatca taaaggccgt tgcgtttaat 3009541 gctgccgccc ccgtaaacaa gcagtacatt cttgccgtat cgtttgaatt cttttcttaa 3009601 ttgttcaagc tgaccttttc caaaaatcag ctttgtcgga ttataataag tgaaattttc 3009661 catagtaaaa cctccaaatg atgctggtaa aaaacagatt ttccattgta acataagttg 3009721 acaaaaaaga aaaagggaag cagccaaacg gctatttccc ctttttttat agtgatgctt 3009781 tcaaaattga cagcacatct tctttgttga gtgatttaaa ttggccgaat gtaccgttag 3009841 ccattgcctt gtcagcgatt gtgtcaagct gctcatcatt aatatcataa tcagcaagac 3009901 ggttcggagc gccaagactt gtccagaatg cggacagctt atcgatacct tcaagggcaa 3009961 tttcttcatc cgttttacct gcttcttcaa catcaaacac gcgaactgca agctgtttca 3010021 tgcgggcagg gttttcagac aatgtgtgtc tcatccaatt cgggaacaga atcgccagtc 3010081 cgccggcatg cggaatatca taaacggctg atactgcatg ttcaatatta tgagtagccc 3010141 aatcccctct tgcccccata gaaagcatgc cgtttaatgc gattgttcct gtgtacagga 3010201 tcgtctcacg caattcgtaa ttttcgagat cattgatcag cttaggcgct gtttcaatga 3010261 ctgtacgcaa aagtgattca cacatgcggt cctgatacgg cgtgtttgat acatgatgga 3010321 agtattgttc gaatacgtgg ctcatcatgt caaccatccc gtagatcgtg tggtttttag 3010381 gtacggtgaa tgtattcacc ggatcaagaa tcgagaattt agggaatacg agcgggctgc 3010441 cccagccgta tttttctttt gtttcccagt ttgtaataac agatcctgag ttcatttctg 3010501 aaccagttgc agcgagagtc aataccgttc cgaatggcaa agcatctttt ggctgatgct 3010561 ttttcgtaac gatatcccac gcatcaccat catacttcgc tcctgcggca atcgcttttg 3010621 tacagtcgat tacgcttccg cctccgacag ccagcaagaa atcaatgttt tgttctttac 3010681 agatggcaac acctttatta acagtcgaca cacgaggatt cggttccaca cctgctaatt 3010741 catgcacggt cgctccggct ttattcagct gttcaatcac ttgatcatac aggccgctgc 3010801 gtttaatgct gccgcctccg tacacaagca atacgttttt tccgtaaggt ttgagttcct 3010861 ccggaagtct ttccacttcg ccgcgcccga aaattaattt ggtcggattc cagtatgtaa 3010921 agttttgcat gacatctcct ccttagattt tttattatgc agaatgtcct caccacatgt 3010981 aaagcaatca gctctcaccg atcagcatac cagatggttt tattttgcaa ggtgctggga 3011041 aagaagctga tataagcgag ggcaggccag cttccctcat atggagaatg catgtataga 3011101 ttctccaata tgtcacaatc tataactgtt ttaataattc atggaggagg ttgcaaaaca 3011161 tgagtaccat tcaaagaatt tgtcttgtat taaccatcat tggcgccatt aactggggac 3011221 tgatcggatt tttccaattt gacttagtag cggctatctt cggcggccaa gggtcagctc 3011281 tttcccgaat catttacgga cttgtcggaa tcgccggctt aatcaacctc ggtctgctat 3011341 ttaagccaaa cgaggaaaga tcacgtgaag aagcagcaaa tcctgaaatg cgataggata 3011401 tcaatcacgc tgaaatagga ttttgcatga aatcaaaagc accgaacatt cctgtccggt 3011461 gcttttttca tgcttatttt ttgataaggt ctttgcggtt ggacatttcg atccactctt 3011521 caagcttatc ttttaatgtg ttgaaacctt gtggtgtaga agcttcttcg cttacttgag 3011581 cagctttagg ttttcttggt ttgctttctt ttttctcagg cgcagcttgt gtcgcacgaa 3011641 ttgaaaggct gattttgcct ttttcttcat caacagcaag tacttttact tgtacttcgt 3011701 cgccaactga aaggtgctcg ttgatatctt ttacgaaacc gtgagtcact tcagaaatgt 3011761 gtactaaacc ttgagtttct tcatctaatg caacaaacgc accatacgct tgtaatcctg 3011821 taactttacc agtgtaaaca ctgcccactt caaattttgc tgccattcat aacaactcct 3011881 aagttaaatt aaatatctgt ttatacgcaa tttaaaatta tatcacacat gtcttatttc 3011941 cgcaaagaaa acttttttat aaaaaatcag gtttatgcac agcaaaaagg gggtaaactg 3012001 aaaataccaa aggctttcta gtattccccc cttttattgg atgcgaacaa aaggttcgta 3012061 tcttttttta tgttgttttg tgcaggaagc gtttcattct gactaacgct tcttgaagct 3012121 gttcaatcga ggttgcgtat gaacaacgga tatatccctc accgctcgga ccaaacacac 3012181 ttccaggaac aactgccact ttttcctgcg tcagtagctc ctcggcaaac tgttctgaac 3012241 tcattcccat gcttttgata gatggaaaag catagaaagc gccgcccgga tgatgacagc 3012301 tgagaccgat ttcattgagc gattctacaa acagattccg tcttcttcga tagctttttt 3012361 tcattttttc tacgtcttcc atgccgttct tcaggccttc aagggcggca aactgcgcca 3012421 ttgcgggcgc gcacatcatc gcatactgat gaattttaag catggcatcc cgaagcaagg 3012481 atggtgccgc ggcaaaaccg agcctccagc ccgtcattgc aaatgctttt gaaaagcctg 3012541 agatgactac cgtccgttcc ttcattcccg gtaatgccgc tatacttgta aattcctcat 3012601 catatgtcag ctccgcgtag atctcgtcgg ctaagacgat gacatcatgt tttttggcaa 3012661 actcagcaat ctcattcagc tcttccttcg aataaaccga acctgtcgga ttcgatggtg 3012721 agcagatgag aatggccttt gttttttcag tgactgccgc ttcaaaatca gcagccgttg 3012781 ctttaaatcc tttgtctgcc gttgtatgaa cgtgaaccgg gataccgcct gccaaagaaa 3012841 caagcgcatc gtacgcaaca aaacacggct caggaatgat gacttcctca cctggattca 3012901 caatggcgcg gatcgcaata tccaaagcct gacttgcccc cactgtcaca atcagctcat 3012961 tatctggcga gtagctaagg tcaaacctgt tgctcaaata acggctgatt tcctcccgca 3013021 atgagtataa acccgcattg gccgtgtatg acgtatatcc ttgttcaaga gagagaatgc 3013081 ttgcttcgcg gacattccat gcggtaacaa aatcaggctc gccgacgcct aaagaaatga 3013141 cgccttccat cgttgccgcc aaatcaaaga atttgcggat gccggatggt tttatttgtt 3013201 gtacatagtc tgataaatac gaagtcattt acggtgacac cacgattctt ttgtcgtcgt 3013261 ctcctgtttc aaacactttg ccgtcatgct tgtatttttt caggataaaa tgggttgtcg 3013321 tagatacaac tgaatcaagc gttgagagtt tatccgaaac aaaacgcgct acgtcagaca 3013381 tcgaattgcc gcgaatcacg acagacaaat cgtatacgcc tgacatcagg taaactgatt 3013441 caacctcttg gaatcggtaa atccgttccg ccacttcatc aaaaccgacg ccccgcttcg 3013501 gcgttacttt gacgtcaatc atggccgtaa cgccctcatg tccgtcgact tttcgccagt 3013561 caatcatagc ggaataatcg ataataacct tttctttctc cagtttgtca ataattgttt 3013621 tcacttcatt tacagggatg cccgccatct ttgcgattgt ttctaaatcg gcgcggctgt 3013681 tttcgtctaa aatttctaat atttctgttt ctttttctgt caatttcatt tgattcacac 3013741 ctttgcaatg tcaagaaatc tcatgacatt atatcacgtt ttttgacgaa tgctaagaaa 3013801 aaacgaggag aaacttccgc tagaattgac aatttcaggg cataatacaa ccatcaaaaa 3013861 aagggagtga cacagaatgg aggcggtttc accaataagg cggtttacgg tcgatggagt 3013921 caatgtatac tacgaacatt atcaaaatcc cggcaggcaa acgctggtct gcgtacacgg 3013981 ttttttatca tctgcattca gcttcagaaa agtaattcct ctccttcggg acaagtacga 3014041 catcatcgcg cttgatttgc ctcctttcgg ccaatctgaa aaatcaagaa cgtttatcta 3014101 tacctatcaa aaccttgcta agcttgtcat tgggattttg gagcacttgc aagtgaaaca 3014161 ggctgtgctt gtcgggcatt ctatgggcgg gcagatatcg ctgtctgctg ctctccaaaa 3014221 acctgagctt ttttcaaagg ttgtgctgct ttgcagttca gggtatttaa aacgttcaca 3014281 cccgacgatt attttcggga cccatatccc gtattttcat ctttacatca aacgctggct 3014341 ctcgaaagaa ggcgtgatga aaaatttatt aaatgtggtg catgacaaat cgctgattga 3014401 tgaggagatg attgacggct atggcagacc gtttcaggac gagcagattt tcaaagccat 3014461 gacaaggttt atccgccaca gagaaggaga tttagaaccc gagcaattga agaaaatgaa 3014521 caagcctgct ctattgattt ggggcgagga ggatcgaatt gtcccaatgg agatcggtaa 3014581 acggctgcac gcagatttgc ctaattccgt gctgtactca cttggccaga ccggacatct 3014641 ggtgcctgaa gaacggcctg aacttatttc tgaacacatt gctgatttta tcaaataaca 3014701 aaaaaaccgg tgctgaaccg gtttttttaa ggcgtgcagg agctgctgtt tttaatgaat 3014761 aaaagctggc cagccacttc ccggcagctg gcgatcggca gcgtttgttc aaaagaagtt 3014821 tcaaatattt gctgaatgct tttcgccagc aagtcgggat cgttttcatc atagactgcc 3014881 tgcacgacat caacagcctc cgtttcgtaa aactcttctc catatttaaa cgggtcccat 3014941 ttggcaatga tcttaatcat ttccctgacc gcatgacttt cttccatatt catcaccgct 3015001 tataataaaa tttgcagttc tatcttatca tagtgaagct tagaagaata aacatacatg 3015061 agggggtaac agaatgaact ttgataaacg agaagaacgc cttggcaccc aatcggtcaa 3015121 atgggataaa acaggcgaat tatttggcgt gacagacgcc ctcccgatgt gggtggcaga 3015181 tatggatttt cgcgccccgg aagcgataac tgaagcgtta aaagagcgtc ttgaccacgg 3015241 tatttttggt tatacaactc cagatcaaaa aacgaaggat gctgtgtgcg gatggatgca 3015301 aaacaggcac ggctggaagg taaatccgga aagcatcaca ttcagccccg gcgttgtaac 3015361 agctttgagc atggcggtac aagcttttac ggagccgggc gatcaagtag ttgttcagcc 3015421 tccagtttat acgccttttt accatatggt ggagaaaaac ggccggcaca ttttacataa 3015481 tccgctgcta gaaaaagacg gcgcatatgc aatcgatttt gaagatttgg agacaaagct 3015541 tagtgaccca agcgttacat tgtttatttt atgcaatcct cataaccctt ctgggcgttc 3015601 atggagccgg gaagatttac tgaagctagg cgaattgtgc cttgagcatg gcgtcacagt 3015661 tgtatcggat gaaatccatt ccgatttaat gctgtacgga cataaacaca cgccgttcgc 3015721 ttcgctctct gacgatttcg ctgatatttc cgtgacatgt gctgctccaa gcaaaacatt 3015781 taatatcgcc ggattgcagg cttcagcgat cattattccg gatcgcctga agcgcgccaa 3015841 gttttccgca agccttcagc gaaatggttt aggcggactg aacgcgtttg ccgtcactgc 3015901 aatcgaagcc gcgtattcaa aaggcggacc gtggcttgat gaattgatca cttacattga 3015961 gaaaaacatg aacgaagcgg aagccttttt gagcaccgag ctgccaaagg tcaaaatgat 3016021 gaagccggat gcatcatact tgatttggct cgacttcagc gcttacggct tgtccgatgc 3016081 agagcttcag caaagaatgc taaaaaaagg aaaagttatt ttagagcccg ggacgaaata 3016141 cgggcctggc ggagaaggat ttatgcgcct gaacgccgga tgctctcttg caaccctgca 3016201 ggacggcctg cgccgcatca aagccgcatt atcgtaaata tagctgtaaa cgcctttacg 3016261 tcttcatttg taaaggcgtt cttaataaag gaattttata ttttacttct aatatttagt 3016321 gttataatag attcatattt tatacgaaag gatttcacac gaatggaaat tctaaaagac 3016381 tatcttctgc acatctgctt tattttgttt cctattcttc tttaccaagt gttttggctt 3016441 ggaaaacctg cgattcttgt gccaaaaata aacagcggtt tggtcacgct cttcgcctgc 3016501 ggcgcctccg ttttatgcat tattttcccg attcatgaaa tggactacat acaatacggc 3016561 cttcagatga ttcccgttat catttgttta ttttacatta gtaccgcttc cggacttaca 3016621 gtcgccgcat ctgtcctatg ttttgaactg cttttttacg aaccttccgc aatgtttgtt 3016681 ttcactttgc tgccttttct tatcattatc ccaatcttat ttcagaaaaa atggccattc 3016741 atgtccaaag cgaaaaaact gctgctgtct ttattgatca gctgcgtgga gattttccta 3016801 tttttcgcct caagctggat tctttccgcc ttgaatattt taaattttca aaaatcagga 3016861 attttcgttt acgaggcggc agtctcaggg cttttccgct ccagtgttct tctattaagc 3016921 atctatatta tcgaaagcat cgccgaaaat atcgccctgc gttcacagct tatccattct 3016981 gaaaaaatga cgattgtgag tgaactggca gcgagcgtcg cccatgaggt caggaatccg 3017041 ctgacagttg tccgcgggtt tgtccagctg ctttttaatg acgaaaccct acaaaacaag 3017101 tcgagtgcgg attacaaaaa gcttgtactg tcagagcttg accgggcgca aggcattatc 3017161 acaaactatc tcgatatggc caaacagcaa ttatacgaaa aagaggtttt tgacctatct 3017221 gcccttatca aagagacaag ctcccttatg gtgtcgtacg ccaattacaa gtcagtaacc 3017281 gtcgaggctg aaacagaacc ggaccttttg atatacggag acgcaacaaa gctgaagcag 3017341 gctgtcatca acctgatgaa aaacagtatt gaagcggttc ctcacgggaa ggggatgatc 3017401 cacatatcag ccaaaagaaa cggccatacg atcatgatta acatcacaga caatggggtc 3017461 gggatgacag accatcaaat gcaaaaactc ggcgaacctt attattcctt aaaaacgaac 3017521 ggaacgggac tcggcctcac cgtaaccttt tccattattg aacatcatca cgggaccatt 3017581 tcatttaaca gcagcttcca aaaaggcact acggtgacca ttaagcttcc cgctgatctt 3017641 cctcactagc aaatcgattg gaactttaat agaataaatg cgaggtgatg acagatgagc 3017701 acgtttgaga caggctctat cgttaaagga ttttacaaaa caggtgtata cataggagaa 3017761 atcacggctt gcaggccgca gcattattta gtgaaagtga aagcggttct tacccatccc 3017821 gctcagggag accttcatca tccaaaacag gcggatgtgc cattttttca tgagagaaaa 3017881 gcgctcgcat atggtgaaca gaccaatatc ccccaccata tggtgaagcc ttatgacggt 3017941 gaagtgccgg attataccga atctctgcgg gaggcgacag cacagatgag agccaaattg 3018001 aatgaggatg gttcggagtg ggcaaagcgc tcccttcata atctggacat tttagaaaaa 3018061 gaatatttta accggccata acccagtctg acaaaagatt gggtttttta cgtcgcgcgc 3018121 ttcaacagtt cggttaaatc gattctctcg ccgattgtgg gcggttttgg cttttcgaga 3018181 tactgcttat cctgctcaac aagcttaaaa agtttatatg ctgtgagagc atcatcaagc 3018241 gctttatgat gggtgccggt tccggaatct ccatactctt cggcagcttt ccataaaccc 3018301 gtcaatgtcc ggtctccaaa aaagtttttg tattcaagcg ataaatctct catttctccc 3018361 ttaaacggga aagggatatg gttaaacata cagttttgct tcagcacttt catatccatg 3018421 tttccccacg taataattgt gctgtttttc tcaggatcca gctcgtttag tttacggatg 3018481 aaatcctcga atctcattcc ttcgtctacc tgtttttggg ttatttttaa aaatgatttg 3018541 cagcgtttcg taagcttcgg gaactttttc ggtctaacat agctagaaaa cgtctcaacc 3018601 acttcatcat caatcgactt tacaattccg gcttcaatga tttccgggaa gaagttttga 3018661 ggactgtact ttccatcagg cattgtaaat tcgaaatcaa taatgagtaa gctgtttgtc 3018721 gtcacctttt acacctgcct ttcctccgat cagaaaatgc tatctttata gtatatcaat 3018781 tccccttctc gacatttctt cattttctaa aaataatgaa ttttcccagc cgcttcgttt 3018841 cttttaaatt gtgaatcgtt tctttataat tagtaaggaa cccgaaataa taagaaggtg 3018901 atgttatttc tatccgtaag aaaaactttg tcattgtgtg gctggcgaac ttttttgtct 3018961 ccgctagcac aacgatgatc gttccttttc tctccttata cattgagacg ctcagctctt 3019021 tttcaaacgg ctttgtgcaa aggtggagcg gctatgtgtt cggcattaca tttctcatgg 3019081 cgtttttggt atccccgttt tggggacggt tcggagacaa acgcggatac aagaaaatcc 3019141 ttatggcaac cggaacaggc attgccctca gcattttctt catgggcttt gttacatcgg 3019201 tgtaccaatt gttttttctg cgtatggcaa tgggtcttgt aaccggattc atcccgacat 3019261 ctcttgcgat gatttcggca cagactccga agagctcagc tggcaaaaca ctcggcacgc 3019321 tgcaaatggg gcaagtgtcc ggaagcttgt tcggcccgct tttgggaggc atgcttgctg 3019381 atcgtttcgg ctttacgtat acctttttta tcacatcctt tgtgattttc tcgtctgttc 3019441 ttctcgtgtt atttggtgtc aaagaaaagc atcttgcaga gaaaacagcc aaacgtacgt 3019501 cttactcgag aaaagaagtg ctctcctata tttttcacca tccggcgctg tgggtcatga 3019561 tgctgttaac catgctgatt caaacaggca atttcagtat ccagcccctg ctcgctttat 3019621 atgtaaatga gctgcacgga cctgtcaatc ttgccttttt ctccggcatg gcattttcag 3019681 caacggggct cggaagtttg ctgctggcta gaaaatgggg tgatctgggc gaccgctacg 3019741 gccaccgccg cattttaatc ggacttttgc tcgccgcctc tttctttttt attccgcagg 3019801 cgctcgcgtc ctcactcagc gtgctccttg ttttcagatt tttattcgga atggcgatgg 3019861 gcggtttgct gccatgcatt acggcagcga tccgcgttca ggctcccggc agcattcaag 3019921 gtgaagttct cggctacaat gtcagctttc gctttttagg aaacgtgctc gggcctctgc 3019981 tcggcggaat catatcgagc cattttacca tttcggccac cttttacgtc acggcgtttc 3020041 tctttttcgc cggcgcctgc atgctttgga tcatgcagaa acttcggaaa gattcttatg 3020101 ccaaagcaag ctgattccga gaaaaaacta aggaatcttc taaatttaac cttctcgtaa 3020161 tctcaaaaga atggtacgat atggctagaa tttaggagaa aagagagtga ccatgttacg 3020221 aaaaataatc ggatggattt tgctcctttg cataatccca ttgtttgcat ttacagttat 3020281 cgcttccgga aaagaagtaa aacaaatgaa gtccctggat caggtgcttg ataaaaatat 3020341 tgatctgaaa gatatcagcc ttgttcagaa cagctacatg tatgacaggg acggctccct 3020401 tgtctcggaa atcgtcagcg accacgaaaa ccgtgtgctc gttccattta acaagattcc 3020461 cgaggaagtc aaacagattt tcttaacatc tgaggaccgc catttttacg agcataaagg 3020521 ctttgacttt atgggaatgg tgcgggctac tgcttctaac gtaaaagaca agaaaattga 3020581 ccagggtgcc agcaccatca cacagcagct ttcaagaaac ttgtatttga gccacgaacg 3020641 ctccttcagc cgcaagctga cagagctcgc gtattcctat cagctggaga aaaaatatac 3020701 gaaaaatgaa attcttgaag cttacttaaa taccatttat ttcaacaacg gtgtttacgg 3020761 cgtcggttca gcagctcaat tctatttcag caaaccgctg aaatctctca cagtgggaga 3020821 aatggctttt atctgtgcta tacctaataa ccctacatta tatgatcctc tcaagcattt 3020881 tgactacacg aaaagccgtc aagaacgttt acttaaaggg ctaaaagatg ccggggtcat 3020941 tacggacaaa gagctgaaaa aagccgtaaa acaaaaaatc aaactggatg ttgaaaaaag 3021001 agaagacaaa tatcctgact acgtttccta cgtcaatgat gaattcactc agctggtgtc 3021061 tgaatcagaa ggctttgata aacgccttca aaaagcatca ggaaaacaaa aagaaaagat 3021121 cgagaacgag ctgtccgcaa gagtcagcac gctgatgaaa gacggagtga aaatttatac 3021181 tgcacttgat ccgtacatgc aaaatcaagt tgtggcacaa atgaattcca agctcccgta 3021241 tgcggacgta cagggcggag cggctgtgat taatcaccag acgcatcaaa tcattgctct 3021301 atccggcggg aaaaactatc aaaaatatga ctttaaccgc gcctaccagg cgtacaggca 3021361 gccgggttca tccattaagc cgcttcttga ttacggccct tatattgaac agaccggcgc 3021421 gacaacaagc agcaccattg atgccagcaa gttttgcagc aaagactact gtccgcaaaa 3021481 ctacaataac cgcacttacg gcacagtgac gcttgatacg gcgtttaaaa attcatataa 3021541 taccccggct attagaatgc tcgaccgcgt cggcatccaa aaggcattca gttatattga 3021601 gccgtatcat tttgccaaac ttgtcgacag tgactatctt cttccggcgg cgcttggcgg 3021661 atttacaaac ggcatgacgc ctcttgagat gacaaaggct tatacgacat tcggaaacag 3021721 cggaagctat acgccgagcc atgcgattac aaaggtgaca gaccttaaag gaaaaacact 3021781 ttataaatgg aatgataaag cgactcaaat attcagcgtc cgcacgaaca tgcagctgaa 3021841 aaaactgatg tcttccgttg tgaaaagcgg aacagggaaa aaagcatatt tcaatgcgcc 3021901 ttacatcggc ggtaaaaccg gaacatcaaa tgattatcac gatatgtggt ttgtcggcct 3021961 gactgatacg tatacaatgg gtgtctgggt cggaaaggat acaccgacca gcgttgaata 3022021 tcttcacagc atcagccctc agctttccat ctggaaagga acgctgcaag cggcttatta 3022081 aaggatcgga ggggatatgg agtgacttca gaacaaattc caaatcgcgt tttgctgttt 3022141 gacggtgtct gcaatttatg caatggcgcc gtgcagttta tcattaaacg tgatccggac 3022201 ggattgattt ctttcacatc gctgcagtcg gaaacaggac agagcctgct gaaaaaaagc 3022261 gggcttccga ctgatcggtt tgacagcttt gtctttattg aagacggcca agtgtacaca 3022321 aagtcaactg cagccattaa ggttttcagg catctgcgag gcccatggcg gctcttcgtc 3022381 ctttttttcg cagtgccgaa gcctgtcaga gatatggtct attctttcat tgccaaaaac 3022441 cgctataagt ggtttggcaa aaaaaatgaa tgtatgctcc cctccccttc cattaaaaaa 3022501 agatttttac cgtaaataaa aaatggctag gaagctagcc atcacagatt gttgacaaaa 3022561 tcctaaaacg gcttcgtttt aggattttgt catctattca gcgtgattga aaacttttga 3022621 agttgtgaaa cggcggaaac ctgagaatct agccgccgtt tcattgcgta cagagcacga 3022681 agcgcaaatc tgaccaccaa acgctgaaat ggctagctta cacaggtaag ctagccatta 3022741 tgctattata aagcttgata aatatgaaca gaataccgat aacaaaggta aaccaaaaca 3022801 gcagttccaa tagaatgaat ccaactaatg acatgagaga aagcgtcgaa taaatccggt 3022861 atacggtaaa cacaaagtaa gcgagcgtga cgaccgcaaa ccagatcaca atccaaatga 3022921 cattttgcaa gagcacaaag gataaaatcc cgccgcccaa ataaatcatg gaacccattc 3022981 tgagtttttt caggttgttc ccttccggat cattagcaaa aaacagcaat gacagctcgg 3023041 tcacggtatt tgcaattaat ttcagagcgg acagaaccat aaaatataaa agtgcaaagg 3023101 cagcaaataa cgcaagcctg attcctttct ctgaaaaata atcgagcatt ccatcataca 3023161 ttccaaatga agacagcatc ttcaacgcat aaagtgaagt tgagatggat aaggacgaac 3023221 taaaaagcag gatcgcaatc agcggaaaat atcctgtcaa ataagtattt ttcatataaa 3023281 aaagtccctt tctataatct acctcattta ttatggagga cttaaaacac attgacaaga 3023341 taaattattc cattttttct cctttttacg aattacgggc ccaaatcttc acaaagcagc 3023401 attttgagag taaagtagta cgcaggaatc ataaaacgta aggaagtttt atatgaaaaa 3023461 aacattaaaa ctgcaaacca gactcaccat atttgtttgt atcgttgtat taatcgcatt 3023521 gctcattacg ttttttacag tcggtgccca aaccaccaaa cgaattagag atcaggaaaa 3023581 ggccactgcg ctgcagactg ctgaaatggt agctgaagcg ccgatgacag ccgctgcttt 3023641 agaaagcgga aaaaaacaaa aggaactgca gagctacaca aagcgggttc agaaaattac 3023701 cggcacggaa tttgttgtcg tcatggatat gaacggtatc cgcaaaactc atcctgaccc 3023761 gagcaaaatc ggaaaaaaat tcagaggcgg tgatgagtcc gaggtattaa aagggcatgt 3023821 ccatatcagc acagcctctg gcacgctcgg gaaatcgcag agagcgttcg tccctgtcta 3023881 cgcggagaat ggaaaacagg tcggtgcagt cgcggtcggc atcaccgtaa atgaaattga 3023941 tgaagtgatc agccatagct tacggccgct ttactttatt atttgcgtca gcatcttcgt 3024001 cggtgtgatc ggagccgtta tcgtcgcccg tacagtgaaa aatatcatgt acggacttga 3024061 accttatgaa attgcgactc tgcttgaaga acggagcgcg atgctggaat cgacgaagga 3024121 aggaatactc gctgtcgatg aacatggcaa aattaaactt gccaacgcgg aagcaaaacg 3024181 cctattcgtc aaaatgggca tcaacacaaa tcccattgat caggatgtag atgacatctt 3024241 gccgaaaagc cgcttgaaaa aggtcattga gacaaaaaaa cctcttcaag acagagacgt 3024301 ccgcattaac gggctggagc ttgtgtttaa tgaagttcct atccagctga aaggacaaac 3024361 tgtcggagcg attgcaacat tccgcgacaa gaccgaggta aaacatttag ctgaacagct 3024421 ttccggtgtt aaaatgtatg caaacgcact gagagcgcag tctcatgaat ttatgaacaa 3024481 actgcatgtg atattaggtc tcgtccagct gaaagagtat gatgatcttg gagattatat 3024541 taaagatata gccatacagc aaaaatcaga aacaagtgaa attataaatg atgtcaaaag 3024601 ctccgtactg gccggttttc tgcttggaaa gcaaagcttt atacgtgagc agggcgcaaa 3024661 tcttgatatt gaatgcaacg gtgtcatccc gaacgcggca gacccttctg tcatccatga 3024721 acttattaca atcatcggaa atctcatcaa caatggctta gatgccgttg ccgatatgcc 3024781 gaaaaaacaa atcaccatgt ccatgcgctt ccataacagc atacttgata ttgaaattac 3024841 cgatactgga gcaggcatgt ctgaagaaga ccaagccaaa gtatttgaac aaggctattc 3024901 aacaaagggc aaaaaccggg gattcggcct ttatttcaca cagcaaagca tcgaaaattt 3024961 aaaaggccaa atgatcctca caagcgaaaa gaatgaagga acgacattca gtattcgcat 3025021 cccgtacgaa ccgaaggagg aaaatcatga ttaatgtact aatagttgaa gatgacccca 3025081 tggtgggtga attaaataaa cgatacttaa gccaaataga tggctttcag ctgaaaggca 3025141 tcgcttcttc ctttcaaagc gctctgcata ttttagggga gcaccatatt gacctcattt 3025201 tgcttgatat ttatatgccg ggaaaaaacg ggctggaact gctgacggaa ttgagagccc 3025261 aaaatgaagc ggttgacgtg attgtcatct cagcggccag cgagcttgac gtgatcaaga 3025321 aaacacttcg gtacggagct gttgattatt taatcaaacc gtttgaattt gaacgattcc 3025381 aaacggctct gtctgattac agacgaaaac aaaaggtgta ttcaacccat cgcaacatga 3025441 gccaaaaaga actggacgcc gagctttttc aaaagaaaga agcaacagaa aaagtgcagc 3025501 ttcctaaagg cctgacaaaa agcacgctga agctgatctg gtccagtatc cagtcatttg 3025561 aaaatgaatc ttttacgaca gaagacttgg caaagcacac agaaatctct caagtatcca 3025621 tacgaaaata cttaaagttt cttgaagata tacaggttct gaatgtagaa atggcgtacg 3025681 gaacgatcgg aagacctgtg tttcagtaca acgtcaacaa cagtaacatt aacggaataa 3025741 agcaatatct ataagaaaac gcactgcttg ctttgagcag tgcgtttttc tgtcatatct 3025801 cttgccaaga tgcttgattc tattgttgat aagttataca agaataacaa agggctttca 3025861 catttttaag caaataattc taaaaataga taatttttaa aaaattatgc gaaattctat 3025921 ttatttctta ttagttaaat gataaattat gattggttag ttgatcccga aaaactaagt 3025981 cataagtctt acttcagaaa acgatgtcac ggttttccgc ccggaacgcc ttccgcatcc 3026041 ttctcttccc cgcctttcga aggaaatact cacaccacgc ttattcaggg aagaatagaa 3026101 ctgtctcagc gcattccatt tgttattatc agaaaatttt atcgattcta agaaattgtt 3026161 caggacagcc catcacatga ctggccggat cagctttgaa ccaaattttt ctggggggtt 3026221 atatcttgaa taaacgaaaa atcggattgg cgatgtcact tgtgatcgca gcaggcacca 3026281 tattaggagc atgcggaaac agcgaaaaaa gcagcggctc aggcgaaggc aaaaacaaat 3026341 tcagtgtggc gatggttact gacgtaggcg gagtggatga caaatccttc aaccaatcag 3026401 cctgggaagg catccaagcc tttgggaaag agaatgggct gaaaaaaggc aaaaacggtt 3026461 acgactatct tcaatccaaa tctgatgcag actatacaac gaacttaaat aaattggcgc 3026521 gtgagaattt tgacttaatt tacggcgtcg gctacttaat ggaggattca atcagcgaaa 3026581 ttgctgacca gcgtaaaaat acaaactttg cgattataga tgctgttgtc gataaagaca 3026641 acgtcgcaag tattacgttt aaagagcagg aaggctcatt tctcgtcgga gtggccgcag 3026701 ccctatcaag caaatcagga aaaatcggct ttgtaggcgg catggaatca gagttgatca 3026761 aaaaattcga ggtcggcttc cgtgccggcg tgcaagcagt taaccctaaa gccgttgtag 3026821 aagtgaaata cgcagggggt ttcgataaag ccgatgtcgg taaagcaacc gccgaaagca 3026881 tgtataaatc aggcgtagat gttatttatc actctgcggg cgccactggc acaggcgtct 3026941 ttactgaagc gaaaaacctg aaaaaagaag atccaaaacg cgatgtctgg gtcatcggtg 3027001 tcgataaaga ccaatacgca gaaggccagg tagaaggaac agatgataac gtcaccctca 3027061 cttccatggt gaaaaaagta gatacagtcg ttgaagatgt aacgaaaaaa gcgagtgacg 3027121 gaaagttccc gggcggcgaa acacttacct acgggcttga tcaagacgga gtcggcattt 3027181 ctccatctaa acaaaatcta tcggatgatg tgatcaaagc ggtcgataaa tggaagaaaa 3027241 aaatcatcga cggattggaa atcccggcaa ctgagaaaga gctgaaaacc ttcaaagctg 3027301 aataagaatc gcagggataa ggaggtcgag cccttatccc ttgtttttct tttattttga 3027361 aataaaggag cggtcaatca atggaatatg tcattgaaat gctcaatatc cgcaaggcgt 3027421 ttccaggtat cgtcgccaat gacaatatca atcttcaagt caaaaaaggc gaaatacacg 3027481 cgttgctcgg tgaaaacgga gcggggaaat caacattgat gaatgtcctt ttcgggctgt 3027541 atcagccgga gcggggtgaa attcgggtgc gcggcgagaa ggtgcacatc aacagcccga 3027601 acaaagcgaa tgaccttgga attggaatgg tgcaccagca ctttatgctt gttgacacct 3027661 ttacagttgc tgaaaatatt attctcggga aggagccaaa gaagtttggc agaattgacc 3027721 ggaagcgtgc tggccaagag gtgcaggaca tttccgatcg atacggcctg cagatccatc 3027781 ctgaagcaaa agcagctgac atatcagtcg gtatgcagca gcgcgcagaa atattaaaaa 3027841 ccctctaccg cggtgccgac attctgattt ttgatgaacc gacggctgtt ttgacgcctc 3027901 atgaaattaa ggaactgatg caaattatga agaacctggt caaagaaggg aagtccatca 3027961 tcttaatcac ccataagctg aaagagatta tggagatttg tgaccgcgtt acggttatcc 3028021 gtaaaggaaa aggcatcaaa acccttgatg tccgtgatac aaaccaagac gaactcgcca 3028081 gtctaatggt cggccgtgag gtatcgttca aaactgaaaa gagagctgct cagccgggag 3028141 cggaagtgct tgcgattgac ggcataactg taaaggatac ccgcggaata gagacagtca 3028201 gagatttgtc tctttctgtc aaagcgggag aaatagtcgg catagcaggc gtcgacggaa 3028261 acgggcaatc tgagctgatc gaagcggtga caggactccg caaaacagat tcaggaacaa 3028321 tcaccttaaa cggaaaacag atccaaaacc tgacgccaag aaaaatcact gaatccggga 3028381 tcgggcatat tcctcaggat cgccataaac acggtctcgt ccttgatttt ccaatcggag 3028441 agaatatcct gctgcaaagc tattacaaaa agccgtattc agcattgggc gttttacata 3028501 aaggcgaaat gtacaaaaaa gcacgcagcc tgatcactga gtacgatgtc agaacgccgg 3028561 atgaatatac acacgctcgg gcattgtcag gcggaaacca gcaaaaagcg attatcgggc 3028621 gggaaataga ccgaaatcct gatttattaa ttgccgccca gccgactcgc ggccttgatg 3028681 tcggagcgat tgaatttgtc cataaaaagc tcattgagca gcgtgatgcc gggaaagccg 3028741 ttcttctcct ctcgtttgag cttgaagaaa ttatgaatct cagtgacaga atcgccgtta 3028801 tttttgaagg acgcattatc gccagcgtta atccgcagga aaccactgaa caggagcttg 3028861 gtctcttgat ggcaggaagc acgcaaaagg aagcggggaa agcaaatggt taaacgactc 3028921 tctcatttac tcgtgccgct catcgcaatc atacttggtc ttgcggccgg cgcgttgatt 3028981 atgcttgtga gcggctacag tgtggctagc ggatattcgg ctttgtggaa tgggatattc 3029041 ggagaaatct attatgtcgg agaaacaatc cggcaaatta cgccttatat tttatccgga 3029101 ttggctgtcg cctttgcatt ccgaaccgga ctctttaata tcggcgtcga gggacagctg 3029161 ctcgtcggct ggacagcagc ggtttgggtc ggtacggcgt ttgacggacc ggcatatatt 3029221 cacttgccgc tcgcattgat tacagcggca gctgcaggag gattatgggg gtttattccc 3029281 ggcattttga aagcgcgatt ttacgttcat gaagtcattg tcaccattat gatgaattat 3029341 atcgcgctgc acatgaccaa ttacatcatt tcaaacgtct tgacagatca tcaggacaag 3029401 acggggaaaa ttcacgaatc cgcctccctc cgctctcctt ttcttgaaca gatcaccgat 3029461 tactcacggc tgcatttggg aatcatcgtt gcccttctcg cagcagttat catgtggttt 3029521 atcatcaaca aatctacaaa aggatttgag ctccgggcgg tcgggtttaa ccagcacgct 3029581 tcccagtatg ccggcatgag cgtgcggaag aatatcatga cctccatgct tatctccggc 3029641 gcttttgcag gtcttgccgg agccatggag ggcctaggga cattcgaata cgcagcagtg 3029701 aaaggcgcat ttaccggcgt aggctttgac ggtatcgctg tcgctcttct cgggggaaac 3029761 acagccgtag gcgttgtact ggcagcatgc ctgcttggcg ggctgaaaat cggcgcatta 3029821 aatatgccga ttgaatcagg cgttccatca gaggtcgttg atattgtgat tgccattatt 3029881 attctatttg tggcttcaag ctatgcgatt cgtttcgtca tgggcaaatt gaagaaaaag 3029941 ggggcgaact aagtggacat tgtgcagatt ttatctatca ttgtccctgc cacactcgtc 3030001 tatgcggccc cgcttatttt aactgctctc ggcggcgtgt tttccgagag atcaggtgtg 3030061 gtgaatatcg gcctagaagg cctcatgatt atcggggcgt tcaccagcgt gttatttaat 3030121 ttattttttg gtcaggaatt aggtgccgcc gcaccttggc tttcgctcct tgccgccatg 3030181 gcagcaggcg ccctgttttc actgattcac gcggcagcgg cgatttcgtt tcgcgccgac 3030241 cagacagtca gcggtgtcgc cattaacatg ctggcgcttg gggcaacttt atttatcgtc 3030301 aaactgatct acggcaaagc gcagacagac aaaattccag agccttttta taagacgaaa 3030361 atccccggtt tgggcgatat tcccgtcttg ggaaagatct tcttttcgga tgtctattat 3030421 acgtctattc ttgcaatagc acttgccttt atttcctggt ttatcttgtt caaaacgccg 3030481 ttcggccttc gtatccgttc tgtcggcgag catccgatgg cggccgatac gatgggaatc 3030541 aacgtatata aaatgcgcta catcggcgtg atgatcagcg gattgttcgg cggtctcggc 3030601 ggcggcgtat atgcctccac aattgcgctt gatttcacgc actctaccat ctccgggcaa 3030661 ggttttatcg ccctggcagc gcttgtattc ggaaaatggc atccgatcgg agcactgggg 3030721 gccgccctgt ttttcggatt cgcccaaagc ttaagcatca ttggatcgct gctccctctt 3030781 tttaaagaca taccaaatgt gtatatgctg atggctcctt atatcttaac gattctcgct 3030841 ttaaccggct ttatcgggcg ggcagatgcg ccaaaagcca atggcgtgcc ttatattaaa 3030901 ggaaaaagat aaacattctc ccctgggaag acgattctca gggatttttt tctaatccaa 3030961 aagaccccct taatttaatt gtttattagt tttttaactt aaaaaaatat gaagtgttaa 3031021 cgctttcttg tagactgtaa caaacaatac atgggggtgt atgacatggg agcaattcca 3031081 aaaacgggga caatttcacc tgagcaaaaa gactcacagg agaaaaacct gtttcaaaaa 3031141 atttggtctt gggaaatcgg tgtgattcct ttgccattat acacagtatt agctgttatt 3031201 attattcttg cagcatatta caatgagctg ccggcaaata tgcttggcgg gtttgccatc 3031261 attatgattc ttggtgtgtt tctcggagac ataggccaac gcataccgat attgaaggat 3031321 attggcggcc ctgctatttt atctttgttt gttccttcat ttttagtctt ttacaatgta 3031381 ctgaattcaa catctttaga cgctgtaacc aacttgatga aaacgtctaa cttcctttat 3031441 ttctatatcg cttgccttgt tgtgggaagt atcctcggta tgaacagaat tgttttaata 3031501 caggggttta tcagaatgtt cgttccactg gttgcaggaa cgatcgcggc cgttgcagcc 3031561 ggcatccttg tcggatttat ttttggctat agtgcctatg attccttttt ctttgttgtt 3031621 gtcccgatta ttgccggggg aataggtgaa gggattttgc cgctttcaat cgcctattca 3031681 caaatactgg gctcatccgc cgatgtattt gtgtctcagc tggtgccagc cgcaattata 3031741 ggaaacgttt ttgctatcat atgtgcagcc ttaatgaaaa agcttggcga caagcgtcca 3031801 gatctaaatg ggaacggacg tctcgtaaaa tctaaaaaag caaatgagat tttcaatcaa 3031861 aaagaagccg aagcaaaaat tgattttaaa ctaatgggag caggagttct gctcgcgtgt 3031921 acattcttta tttttggcgg gttattggag aaattcatct tcatcccggg cgcgatctta 3031981 atgattattt cagctgcggc tgtcaagtat gcaaatattc ttccgaaaaa aatggaagaa 3032041 ggcgcttacc agctttataa gtttatttct tcaagcttta catggccgct gatggtcggt 3032101 ctcggcatcc tctttattcc gttggatgac gtagcgtctg tgatttctat accgtttgtc 3032161 atcatctgta tttcagttgt tatcgcgatg attggttctg gatatttcgt aggcaagctg 3032221 atgaacatgt atccggttga atccgcaatc gttacctgct gccacagcgg tctcggcgga 3032281 acgggtgatg ttgccatttt atcggcatca ggaagaatgg gccttatgcc gtttgcccaa 3032341 atttcaaccc gtctcggcgg tgcaggcaca gttatttgcg cgacagtgct gcttcgtttt 3032401 ttcacttcat aaacagaaag agttccgttt tatgcggaac tcttttttta tttattcaca 3032461 atccgaatat actctcgggg accaaacggc agatcctttg attccgtctc actcattctg 3032521 gctgacaggt ggtgctccag taaatacagc tcccactcat cacaagccgc cacaccgctg 3032581 cgcccgtcat attgattcaa catgaatgcc cctgcaaata ctgagcagaa taaacctgag 3032641 cacatcacga cttttgtttt cacatgacca gctcctttcc ttcagcttga tcaggattga 3032701 ttttaaatat acaaataacc tcttttttgt tagacttatt ttgaggtcaa aagaactcat 3032761 aaaaatccat tacagcagtt cgaagcgtgg cagcttgcag aaaagtgcga tataatttgg 3032821 actaggtcgt ttgaccgtat attttataca tagcgcattt ttcaattgag aacgagaaaa 3032881 ggaggtctta tctttgcagc tcttacatct tgctatttta tcgccttttt tatttgcttt 3032941 tatcattccc ttcttggcaa aatacgcaaa aagagtgcat acgggctggt ttgtgttgat 3033001 cctgcccgtc ttgctgttta tatactttct cccaatgatc aggatgacgc aatctggaga 3033061 aacacttcga tcggtattag agtggattcc gtcactcggc attaacttta ccgtttatat 3033121 agacggcctc gggttattat tcgctttact gatcacaggc attggctctt tggtcactct 3033181 ttacagcatt ttttatttat cgaaagaaaa agaacagctt gggccctttt atgtctactt 3033241 attgatgttc atgggcgcca tgctcggcgt cgttctagta gacaatgtca tggttctcta 3033301 catgttctgg gagcttacaa gcctttcatc ctttttgctg atcggctatt ggtataagcg 3033361 ggaaaagtcg cgctatggcg cagccaaatc acttttgatt acggtcagcg gcgggctgtg 3033421 catgctcggc ggatttattc tcctttattt gataacggat tccttcagta ttcgagagat 3033481 ggttcaccag gttcaattaa ttgccggcca cgaattgttt atcccggcta tgattctcat 3033541 tttattaggg gcttttacga aatcggcgca atttcctttt tacatctggc tccctgacgc 3033601 gatggaagct ccgacgcctg tcagcgctta tctccattca gctactatgg taaaagccgg 3033661 catttatgtg attgcgagat tcagtcctat tttcgccttt tcagctcagt ggttttggat 3033721 cgtgtccctc gtcggcctct ttacgatggt ttggggttca ttccatgccg tgaaacaaac 3033781 tgatttaaaa tcgattttgg cgttttcaac cgtcagccag ctcggcatga tcatctccat 3033841 gctcggagtc agtgctgcgg cccttcatta cggacataca gaatattata cagttgccgc 3033901 tatggctgcc attttccatt tgatcaacca cgcaaccttt aaaggaagct tgtttatggc 3033961 agtcgggatt atcgatcacg aaacaggcac acgggatatc cggaagctag gcggcctgat 3034021 ggcgattatg ccgattactt ttaccatttc cttaatcggg acattttcaa tggccggcct 3034081 accgccgttt aacggatttt tgagtaaaga aatgtttttc acaagcatgc ttcgcgtgac 3034141 acattttgac ctgttcaacg tgcagacatg gggcgttctg ttccctcttt tcgcctggat 3034201 cggaagtgta tttacgttta tctacagcat gaaattgctg tttaaaacat tcagaggaaa 3034261 ttaccagcct gaacagcttg aaaaacaggc tcacgaagcg cctgtcggta tgctcgttcc 3034321 accggtcatt cttgtcgctt tggctgtcag tctcttcttt ttcccgaata tattgtcgta 3034381 cagcctgata gagcctgcga tgaactcaat ctatccgaca ctgcttgacg gccatgagaa 3034441 attccacgtt cacatttcac agtggcatgg ggttacaacg gaattgctca tgactgcggg 3034501 tattgttgtg atcggaacaa ttggttattt gtcgctgaat aagtggaaag gaatctataa 3034561 actgtttcct tcgaaactca cactcaaccg gttatacgat aagcttttga ctatgatgga 3034621 gaaaggctct taccgggtca caaaacaata tatgaccggg tttttaagag attatttgct 3034681 gtatatcttc gctggtttca tcattctgat aggcggagct tttgccatta aaggcggatt 3034741 ttcatttaaa acggaaggca tggctaaaat cggtgtatac gaaatcattt tgacgcttgt 3034801 catgatcagc gccacagtgg cgactgtttt tgctaggtca agactgacgg cgatcattgc 3034861 actcggtgtt gtcggttata cgcttgcatt gttttttgtc attttcagag cgccggactt 3034921 ggcattgact cagctcgtca ttgaaacgat ttctgtggca ctgtttctgc tttgcttcta 3034981 ccatttgccg aaactgaggc tgaaaacaaa aacgagaacg ttccggatga cgaattttat 3035041 catttcttta ggcgtcggtg ttatcgttac actgctcggc atcgcatcct caagccagcg 3035101 gacaaaagac agcattgcgt ccttctttgt caaacacagc cacgatctcg gcggagggga 3035161 taatgtcgtc aatgtcattc tcgttgattt caggggattt gatacaatgt ttgaaattac 3035221 ggtattaacg atagccgctc tcggcattta cagcatgatt aaaacaaaag taaaagagga 3035281 ggggaaaagc ggtgaatgaa caaaaaacaa atgacttgat tcttcaaacc gcgacaaagc 3035341 ttgtatcctt tatcattttg cttttctctt tctatttatt tttatcaggg cataacgcgc 3035401 ccggaggagg ctttgtcggc ggactgatca cgtcctcttc catcgttctc ttgctcttgg 3035461 catatgattt aaaaaccgtg cgttcccttt tgcctgtcaa tttcatttat gtcgcgggag 3035521 ccggccttct gctcgctgta ttaacaggcg ttggctcctt tgtcttcggg gctccttttt 3035581 taacccacac attcggatac tttcagctgc cgatccttgg gaaaacggag ctcgccacag 3035641 cgacgatatt tgatttaggc gtttatcttg ttgtcgtagg cataacgatg accattattc 3035701 aaacgattgg agaggaagaa taatggaaat cttaatggct gtattagccg gtattatttt 3035761 tatggctgct acgtatttgc tgctgtctaa aagcctgctt cgcgtcatta tcggaacagc 3035821 actgttaagc catggcgttc atttaatgct tttgactatg ggaggattaa agaaaggcgc 3035881 cgctccgatt ttgagcgagc atgccaaatc atttgtcgat ccgcttccgc aagccctgat 3035941 tttgaccgca attgtcattt cttttggcgt tacgtcattc atcctcgtca tggcctttcg 3036001 cgcttatcag gaattgaaat cggacgatat ggatcaaatg aggggaaatg atcaacatga 3036061 ataattttgt tattttgcca atcctgatcc cgcttttgtc ggctattctt ctgattttca 3036121 tgacgaagaa tcttatgctc atgagaatct tcagcacggc ggcatcggcc atcgggattg 3036181 tgattagcgg catacttgta cagactgtct tcacaaaagg catccagaca ctcagcctag 3036241 gcggatggaa agcgccgtac ggcattgtgc ttgccgcaga ccaattcgcc agccttctcg 3036301 ttctcacaac agcgatcatc ggtttattgg ttgggcttta ttccttccgt tctgtcggtg 3036361 aaaaacggga gcgctccttt tactactccg gcgttcagtt cttgcttgcc ggcgtcagcg 3036421 gagcgttttt aacaggcgat ttatttaata tgtacgtatt ttttgagctt ctgcttattg 3036481 cttcctatat gctgattgta ttaggcggca caaaaattca gctgcgggaa tcccttaaat 3036541 atattgtgtt taatattgta tcgtctgccc tgtttgtcat aggggtcggc tttttatacg 3036601 ctgtaaccgg tacgttaaac atggcggatc ttagcgtgaa aatcagcgaa tcaggacaaa 3036661 ccgggctgat cactgtgatt ggtgtcctgc tgcttttggt atttggcatg aagggcggaa 3036721 tcttccccct ctacttttgg cttccaggct cttattacgc gccaccggcg gcaatctccg 3036781 cgttgttcgg cgctttgctg acaaaagtcg ggttatatgc gattacgagg gttttcacat 3036841 tgatttttat tcacgataca gcctttaccc atcagttgat gatttggctg gcggcgctga 3036901 ctgtgatttt tggtgtgatc ggttcactcg cttattcgaa tgtcatgaaa attgtgatct 3036961 ataacattat taccgctgtc ggcgtgattt tgttcggtgt ggcagtacac acccccgcat 3037021 ccattcaggg cgcgatctac tatctgattc acgatatgct gattaagggc gctttgttca 3037081 tgctggcagg tacgctgatc gcattgactg gaaccgcgag cctgcataaa atgggcgggc 3037141 tgatcaaacg ctatcctgtt cttggatgga tgtttttcat ttccgctatt tctcttgcag 3037201 gcattccgcc actgagcgga tttgtcggca aatttaaaat tgcagagggc ggcttcgcag 3037261 aaggtgaatt tacgatatcc atgctgattc tgctttcgag tctgcttgta ctgtactctg 3037321 tgctgaggat ctttatacat gcgttttggg gcgaagaaaa agaaacgcca aaaccaaatc 3037381 atcgaacagc taaaggactt ctttatccgg cagctatttt tctcttgctg tcccttctct 3037441 tcggattggg tacagaatgg gtgtcgcctt acgttgatca agcggccgag acgctgctga 3037501 atccggaaaa atatatcgaa gctgttctga aggagtagat cgcatggcat ttcaaatttt 3037561 attaaatgtg tttctcgctt tttgctggat gttcttaagc aacagtccaa gcgccgcagg 3037621 attcattaca ggctatattc tgggaatgct ctctctcttt ttcttccggc gctttttcac 3037681 tcgccagttt tatctatgga aattgatttc tattatcaag ctctgtttca tttttataaa 3037741 ggaactgtac cttgccaatg tcagtgtgat gaaatcagtc ttatctccaa aactgaatat 3037801 cagaccgggt atttttgctt ttaaaactga actgacgaag gactgggaaa tcaccatgct 3037861 ttctctgctc attacattaa cgccgggaac cttggtgatg gatatttcag atgacagaac 3037921 aatactttat attcatgcaa tggatatcga ggatgcggaa aaagcgattt ttgacattcg 3037981 ggagtcattt gaaaaagcca tacaggaggt gagccggtga tgtttacgct gatcctgcaa 3038041 atcgcgctcg gcattatggc agtgtctacc tttttgtatg tcattcgtgt cattaaaggt 3038101 ccgactgtgc ctgaccgggt cgtggctctg gatgcaatcg gcatcaatct gatcgcaatc 3038161 acggcgcttg tctccatttt gctgaaaaca agtgcgtttt tggatattat tttgttgctg 3038221 gggattttat cgtttatcgg aacgatcgca ttttccaagt tcctggagaa aggagagatt 3038281 atcgaaaatg atcgaaaccg ctaaggtcgt tgtggctgta ttcattttgc tgggtgctct 3038341 tatatgcctc attgcttcat ttggcgtact tcgccttccc gatgtgttta cacgcgctca 3038401 tgctgcttct aaaggctcaa cattaggtgt caatatgatt ctgctcggtg tcttcttcta 3038461 tttgtggttt gtgacggggg agctctccgc taaaatcctg cttgggattc tctttatctt 3038521 tattacgtcg cctatcggcg ggcacttgat ctgccgtgct gcgtataact ccggcgtcaa 3038581 gcttgatgag agaagtgtgc aagatgacta taacggaatc agaaactttg tgattaaacg 3038641 aaaagaggat tcttatttat aaaaataagc agccggacag gcagagttcc ggctgttttt 3038701 ttatttcttg atgacagcca gcgtgcatct ggatatacag atcagcctct cttgctcgtc 3038761 atatatgtga atatgataga caatcgtcgt tctgcctata tgaacgggct cggctatcgc 3038821 ctttaccgtt ccttccttta cagattttaa atggttggcg ttaatctcca aaccaacaca 3038881 agcttgcgtt gtatgatcaa tcaggttctg tgcacctgcg ctcgccgcgg tttccgccag 3038941 ggccactgaa gcgcctccat gcaaatatcc gaacggctgt accgtccgat gatccaccgg 3039001 catgaccgca acgcatcgtt ccgctgtgtt ttcaacaatc tcaataccaa gcgcttcaag 3039061 caatgtgtgc ttcatatcca tctctacacc ccccaacatt taaagtacac cgtctgattt 3039121 cgcaatcaaa accgcttccg tccgtgaacc gacattcagc ttattgaaaa tcgatgtcaa 3039181 gctgtattca atggaccgct tgcttaaatg aagggcatct gcgatttctt ggtttgtaaa 3039241 tcccttttca acttcttgaa gaatcaggca ttctctaggt gtgagcacat cttgttcttt 3039301 ttgagaggaa ggagccggct ttgttttttg ctgagtcatc agctgtttaa agtaagcaaa 3039361 atcgactaaa atttctccgt tgagtacgtg gtatatgtat tgggtgatct tttctttaga 3039421 ttccgttttg ctgatggcac cgtgcagacc cgcacgaatc gcttcctcga aataatcctc 3039481 gacctcataa ccggtataca cgataatttt acaatgagga ttctcttgta aaatctgttt 3039541 agaaagctcc atcccattga cctcgccgcc tagattcaga tccattaaaa tgagatcata 3039601 tgacgagaaa tcatgctgct tgataaactg ttcgctcggt tcaggactga gacaatcaac 3039661 agacaaattc gaatccgttt ccaaaattgt cttggtgcct tccatgacag ccggatggtc 3039721 atcaatcact agtatctttt tcatgttttc ctccctttta ctcactcttt tccattttat 3039781 aaaaaagact tggcctgtgc caagtcgttt ccgttataaa tccattacaa ttcgatttca 3039841 atatcagcct taaagccctt tccttcactt gtttcaatcc gaaggcgccc atctaaagcc 3039901 ctgactctct ccttaatgcc agaaagcccc atgctcatgg aatgctcagt atttttttct 3039961 tgatcaaacc caacgccatc gtcctcataa tgaagaacga ttttgttttg aatactgatg 3040021 agcataatca gcacatccgt cgcctgagag tgcttgaccg cattagacag aaactcttga 3040081 atgatccggt acaaattcag ctgcgaatcc agatcaaggg aagccgtaaa tctcccggta 3040141 tttaaacgga tatgaaacgg aacccgctcc tgctgctgcg ccaccagctt cgacagcgcc 3040201 ttcaccaatc caagatcata cagaagctgc ggccgcagct catgacacgt ctccctcgtc 3040261 atcgaaatca catcagacat ctgctcattc atctgtacaa gcttgtcctg cacctcttca 3040321 cggcacggat tatcatcctt cttgaaatca cccaaaaaca gctcacactg gcgttttaag 3040381 gaaatcaaat cctgaagaac cgaatcgtgg agatcgcggg cgagtcctga acgctgtttt 3040441 tcttcgattg caaacattag ctttttcagc cagatggggt tggttccctc ttgttttaag 3040501 tccttcaaat gttccatgag ctcctcaata tgcaggacat tttccatgga cacacttgta 3040561 taaaaagaca gtgttttcag ccacgatatt tcatcacgtg ttagccgggg agtgttaata 3040621 ttagataaac aaagcagaac ataagaacta ccgcctcgtt caccaacttt cataagaaag 3040681 ccttgattga cttctataat tttcccaatt tctgaagtta cgttttcaaa ttcctcttga 3040741 taaaaattcc agtccggtcc aacttcatgc ttatctaaaa atatcacttt gtgatcagga 3040801 gtaacctcaa aggtataagc tttgcttaca agcaaaacat ccagtatagt atttttcagt 3040861 tctttaaaaa cttgttgaag agaagttaca cccctcatta gctgagtata tttaaaaata 3040921 ctgtcctgat agttgaattt ttcggagaaa cgttttaacc gaaatttaaa atccatgacc 3040981 tctttaaaat aaaagacagc gaacatgaca acgaaaaaaa atacagtttg acgcacaggg 3041041 ttcatctgga tgtccattac atcaaacaga actaatgcac caactattag aagagttggt 3041101 atcatggcaa gtagagcata gtatctcatt cttcctaaga taaactctat atcaaacatc 3041161 ttattggcta caaattggta tactaacccg aacggaatta gtactagtaa tgacgccgaa 3041221 gctaatgccg ggaaaatata attacctgta aatattattg gaagaacaaa aaatatcaaa 3041281 aaaggcgcaa atgaaagagt gtttgttaaa attagtaatt taagaataaa cgaatgctca 3041341 gcatatttat atttattaag atgtaagtat atcgctgaaa aagaaaatag agtcaaagtt 3041401 gcaaaagaaa ccaaattaag agttgctaaa aaatcaatat ctacttgtaa atagtcttga 3041461 aaaaactcaa taccaagatt aaatattggt atgatataaa gaaaagaaat tctattcaaa 3041521 aaagttttac ctatttctcc aaggtatctt tgtataaatt gaagataaag aataggagaa 3041581 gatataaaag taaacaagtt aatataccga ttgattatat gtcctctaaa tggtccgcct 3041641 gcacttatat atgctatcga aatgtctaat aacaatagaa taagaatata ggcagcaaat 3041701 gatctccttt ttttatttac tttaagtata taaaaaatac atattatgct taaaaaataa 3041761 aaaaacaaag gaagtacgaa cagaaaaaaa ctataaggtc tatttagagt aactaaatca 3041821 aaatctttga gatgaatctt ttttccactt ctcaaaatat ccagactgtt aatatgactc 3041881 aaatatcccc atttcaaatg tttgtctgaa ggtttttctt tattaatttt taatatgatg 3041941 tctccctgtc tcagaccaac aaattgtcca tatgaagatt ccgatatttc ttctatcata 3042001 aattgacttt tatcattttt atgaatctta gtcccaataa taattccatt catactgata 3042061 taagttgtat agcttatata aaggatactc aaaacaatta cagctattgt gaattttttt 3042121 attaagttct tcaatattaa tccacctatt aatcacccca ttgacgggtt attggatcag 3042181 ccagataata atcattataa gctttaatta ttgtttcagt ttcttgcaca tcaaaaccta 3042241 taaggcaggc ttctttattt ttcaattttt ttaaagcctc aggataattt aaaaagtagt 3042301 taattaggtc ttgcatcttg tatccccctt tgtataactt aataagcatt cctttattag 3042361 ctcttttttt tctttatcta aatttaattg ttctatagca gaaatacatt tctgtttata 3042421 tatttccaat aataccgaaa tgtattgagt aactcccgct ttaattaatt tttcttggaa 3042481 tttctcttta tcaagtaacg atttataata taagtcttta tgtgaaatta agtataataa 3042541 atcttccgaa gcatcattaa aaaggcgctt aagatataag taaatcagtg tatgtttgtt 3042601 tttttcaata tcactgcgat ttccggataa aagaacataa taatctccag aaatttgagc 3042661 tataatccct ttatagtagg aatatctttc aactgtttca ttatattctc ctgtagccaa 3042721 taaaacacct gctacatttg ctagtgcaat cagacttcca cattttaatc taattacttc 3042781 taaactttca tcttctgttt tagatttatt agtgatatcg tcatgttgac cttgcatggc 3042841 ctcgtttacg tattttaaaa catatttaaa aattagagga ttgttattta atgaataaat 3042901 actcgttaat cctactgtat acaaggaaag tgctgcattt aacgactccg agcgattaat 3042961 tttcatccat aatgcatggt gattatcttc atcttcaaga tcatccataa tatctgatga 3043021 aagaataaga atttctattc ccgcgccaag ccttgttgca acatctaaat tctcccctcc 3043081 aaaaacaaca taatgtaaga ttgtggattc agcaaaggag aatgtttctt tagaatcaat 3043141 aaatgagtaa agaagttgtg acaaatcctc gttaaatatg ttttgctcca caatctcctt 3043201 cattttctcc ttgatccgga cagaatctaa acatatctgc tcaataacga cttcccccct 3043261 cccattccat tttactaaat gggacattta aaggacagca ggtttttcgt tttttaacaa 3043321 tcatataata ctttatccat ttattgtatc ggtagaacga aaaaaaagac ttgtttccaa 3043381 gtctttttca cgaaattttc attgcataat tgtatttatc gagttgatca atgcttttgt 3043441 taatgtttcg taatgaatct gtcgtttctt taatatcaag ttcgagtcgg aataacaatt 3043501 gttttacttc ttcaagtttc ttttccatcg tttccacact cctttttttg aaagatcaat 3043561 gaattgtgta tggtgaacga gtcctaggta tttgatctgt tactaatagt gtgtctgctt 3043621 tcggctcatt tttcaccgaa aagtatgcaa aaaagtcctg cgtgacaccg caaatctcaa 3043681 taggtcctta tactcaaagg aatcacaaca agaacgggac tatctttcta tgcgaaagag 3043741 cgtttatatg tgctgaaatt gagaaagatt cttaatctcc ttgattttaa cgggtttcgc 3043801 attttcacta agcaagacta tagtccttca taccgtattt tcaaaattga atatgcgatt 3043861 cttggcgttt cctgaccgac aaacaccgaa aaagaccgca acgctaaagt tgtggccttt 3043921 tcgctttgtc atattcggca attagggatc tatacatata gaaacatcct tttttgcgag 3043981 gtgctcccat gagatatcgt tatccctggt tttacgtgta tccgtatgag gtacgccgtc 3044041 cgcccgctcc tgccaacaat attgatacct ttatccgttc agcgaagcag gccgcaggga 3044101 tatttgcgga tgcccagctc gttctcagcc gcattgcggg ctcgcgggag ctttcgcgcc 3044161 gcattctgac cgcagccgaa cagtctgata aacaaactat aaggcgcctg atcaaacaaa 3044221 tgggcgtccg gcatgaagtg gatacggtct ttaatcccga cggcatctat atcagcctta 3044281 tcggaacgca aagccgaatg attcttgctt tgcggtggtc agaggaccgc aatcattttg 3044341 cgtccataag attatgacac cattccagag cctctaaata acattcatac gcttcttctt 3044401 tgtccagttg attgcctaat tctgagcaag tgtcccagtt gttgctttca attaatttca 3044461 caagctcaag catttggtag tagtcgtttt gatggcctaa taatgcttgc ccgacttcat 3044521 cttttaaagg caattcttga acaatttcct ctatttctct atgcaggagg gtgtctatga 3044581 gagaaaacat tccgatcagc atataagaag caggctgcgg ccgggatgtc tttctcgcca 3044641 gcagttcgca aagctttgct cttatcagag aaatcttaat gatttcgtgc ttgctggaat 3044701 gccctttcct gcttaaatcc ttaaaggaaa gaatatatat ccaccgtttg atttcattaa 3044761 atcccagcag cataatggcc tgttgaatgc tttcaatttt ctggctcaaa cggctgtggg 3044821 atgagtttaa aaattttaaa atttgatagg acagtgataa atcccgctct atgtactctg 3044881 tcacacgctt tatgttaggc tgctctttac tcagttcgtt aagcagttca tagtaagaat 3044941 agaaatgagt cgataggtca tgcccgctga tgatgcgcgg ctcgctgaaa aagtagcctt 3045001 ggaataattg aaagccgtct tggaccgcct gtttatattc ttttcgggtc tctacttttt 3045061 ccgctaaaaa aatcaggccg cggcagccgt aggtttgcaa aattgttctg cgttccattc 3045121 gtgttgtttt gagaaaatca attttcaata tatcaatata gctcatgagt ttttccagta 3045181 agtcctcatc ttgcggattt attgcataaa aatcatcaag cgccagcata taccccattt 3045241 ttttcaattc tttgcatcta gaaatgaggg ccggcgtgat cggtatatct tcaaggattt 3045301 caatgacaag ctgtttcgga ttgaaggagg tgggaagatt cgaaaacatc aggctttccg 3045361 taaaattaac aaaacagcgt ttcccttccg tcagcttctc aattccgatg tttaaaaagc 3045421 tgttgatcac caaatctgtt gttgcctgat cgccgtcttt agcgctatac acgttctctt 3045481 cgctttctct atacagcagt tcataagcaa caacctgttc ttttctatta aaaataggct 3045541 gtcttgcaac aaacaccctc attgatttat cccccttaca atacgcgcgg ctttcacccc 3045601 taagtatatc aaataatttg acgaaaattg tctaaacatg aaaaataata tatacataaa 3045661 gaaaactggc ccttcgcgaa tgaaaggcca gtttttcttt attcttcctc aagctcttct 3045721 tcaattctgc ttttcacttc gtggatccgc tgcattttat tgctccagca gtcctcgctt 3045781 aaatcaaccg ggtattcctc cggcttgctg attctcttat attcctccca aagcaggctg 3045841 aggttatcct gcacatactg ctgtatgtct gaaatctcag ggttttggta gcaaagaata 3045901 cccttctcaa aaatcagttc atgaagatcc ttcgcataaa aattcgtgac aaatttgctg 3045961 atgaatgtat gaaccgggtg gaacattctg agccgcttct gatcattcac ctgctcatca 3046021 taaagcgcaa tatagtcgcc ttcagaatga tggttggact gattaataat gcggtagact 3046081 ttctttctgc ccggtgtcgt cactttttca ggattggacg aaattttgat cgtgtcgacc 3046141 attttcccgt cttcttcaat ggcaacgagt ttataaactg cgccgagagc cggctggtca 3046201 taggcagtga tcagcttcgt accgacaccc cagacatcaa tgcgcgctcc ctgagccttt 3046261 aaattcataa tggtgtgctc atccaaatcg cttgaagcaa tcaccttcgc atctgtaaat 3046321 cctgcttcat caagcatttt ccgggctttt tttgacaggt acgccaaatc gccgctgtcc 3046381 agacggatgc caatgaaatt aatgcggtcg ccgaattcct tggcaaccct aatcgcgttc 3046441 ggcatgcctg aacgaagcgt gtcatacgtg tcaactaaga agacgcaatc cttatgtgtt 3046501 tccgcgtatt ttttgaaagc tgtatattca tcgcggtaag cctgcacaag cgcatgcgca 3046561 tgtgtgccgg aaaccgggat attaaagcgc tttccggctc ttacattgct tgtcgcgcta 3046621 aagccgccga ttaaggctgc tctcgctccc cacatggccg catccatttc gtgcgcccgt 3046681 cttgttccga attcaagcgc aacttcatca ccgatgacgc ctttaatccg ggcagccttt 3046741 gttgcgatta atgtttgata gttcacaatg ttgagcaaag ctgtttcaat cagctgcgct 3046801 tctaccaggg gtgcctccac cctcataatc ggctcattgt taaaaacgag ttctccttct 3046861 ttcatggagt aaagtgaacc tgtaaaagat aagccgcgca aatattcaat aaaatcttca 3046921 tgatacccga gttcatcctg taaataactc aaatcgctat ccgtaaactt gaaattttcc 3046981 aagtattcaa tggctttttc caagcccgca aatacggcat agccattttc aaacggaagc 3047041 cttctgaaaa acagctcaaa aatcgctttc ttttcatgaa tgccgtctct ccagtacgtt 3047101 tccgccatat tgatctgata aaggtctgta tgtaatgaca ggctgtcatc tttaaatccg 3047161 tactctaaca ctgtttttcc ccttccttac tctgccactt gcgctccgat gctgtttgca 3047221 aaatgggaaa gagcccatgc gtgcccctcc tgattaaagc tggcaacagc ttgtttatgc 3047281 acaacaatcc gaaaaccttt gttgtatgcg tcaacagctg tatgcaacac acaaatatct 3047341 gtgcagacac cggcaagatg cagttcgcca atctgccgct ctctgagttt gagctctaaa 3047401 tcagttcccg caaaagcaga atatctcgtt ttttccatgt agtaaacatt aggttcatgt 3047461 tcatgtttct gatatagagg caaaagcttt ccgtacagat cttttccttc cgtgcctttt 3047521 atattatgcg gaggaaaaag acgggtttca gggtgatatt gatccccttc atcatgagaa 3047581 tctactgcta atacgacgta atcaccgttt gtgatgaatt ctttagttaa attgacgatc 3047641 gcctcttcaa tcattctgcc gggctccccg caggtcaatt ttccgtcact cgccacaaaa 3047701 tcattcgtat aatcaataca aataagtgct tttttcatag ccggcctccc cgccatcagt 3047761 atgagaacat tatatcttat ctccagttgt aagtgaattg ccatgaacaa aaagacaaac 3047821 ggtccgtttg tctcttacga tttcagtact gaccgattat aaatgtcgtc ctgaatatat 3047881 atcaattcac gattcacagc gatatcagcc gcaatgacga tgcctaaggg cgtatgaaac 3047941 tggagatcag atacaatctt gaaaggcact ccgtaccggc tcgccatttg gatataagaa 3048001 gagtaagact gatactgaag ctctccatta atcaaaaggg tgacgttatg gctgtttttc 3048061 agctcgtgct ctgcctcttt atacggtttg cttctaagca cctgtccttt cgtcagtgcc 3048121 aaaacgactc tttctcttaa agagcctaaa aacaaatggc gctcgtcagg ctttgtctcc 3048181 aaaggcccat acattccttg ctgcaaatag agatccattt tatcttcact caaaagcctg 3048241 tcctcccgtc ttgtttgtct tcattatcac ctgatcaggc aggagctaaa ctttcaagcg 3048301 ccgtttacat ttctgttacc caatgaatga tttttttggc cagctcacca gcaggggttt 3048361 cctctgtatg ccggcgcaac gacgcttcca gccgttcagg cagagttgct ttatcttctt 3048421 cataggaaat gatcgtgctc cactccagct gcggtaccgc tacaagcgtg cgcagttctt 3048481 ttctgttttc atgcagatac acgtccgtga tcattccggt ttgcgtattg atatttgctt 3048541 ttctgatttt cataacatga cctctctatt caaagactac ccatattata caataaaaaa 3048601 gcaacagcct cttgtgaaaa ggctgttacc cgttaaacga aactgtttca tcagtgatat 3048661 cggcatcttt gaagagagtt ttactcgttt ggttgttaat cttcacaaaa tcaccaagct 3048721 gaaatgtgcc tgaccccgcc cctgaatgag cgacgctttt gggcgaaatc gcaaatacgt 3048781 ctccaaagct tgccgcggca ttatccgtaa ctgacatgat ataaatcggc cccacaattg 3048841 caggcatttc cccacctccg cattgattta cagcatcata tgcaaggagc cgataatggt 3048901 gcccgcctat tcagctggct ttgcgttttc ctcgagtcgt gaccgctggc gcagcttgat 3048961 caagcggaca atattcagga agaacgcctt cactaccgca taaaccggca ccgctaaaat 3049021 catgccgaga attccgccga agcttcccgc tccgattaat agcaaaataa tcgtaagcgg 3049081 atgggtattc agccgctttc cgatcacaag aggagacagc aggtttccgt ccagctgctg 3049141 aacgatgacg accacaataa tcgcaaacag cgctttggcc ggcgagtcca taaaaccgac 3049201 aatgacagcc ggcgcggcac cgagaaaagg cccgacatag ggaatgatat tggtaatcgc 3049261 catgacaatc ccaagaatca gggcatacgg cagtccggca attaaatagc cgataaaaca 3049321 cgctgttccg acaaaaagac agattaacag ctgcccctgg aaatatgccg caagcgtatc 3049381 ggataaatct ttaaaaatct ttaagccttc tgtccgataa gaagccggta gaatttttac 3049441 tgccaaatgc ggaaagcggt gtccgtcttt cagcatgtaa aaaaggataa atggaacagt 3049501 aataataaca agcgtgatgt ttgtcacgac accaaacacc gcagataaac tggacgtgat 3049561 attttgcggc aggttttgga gaaaacttgt caatgactgt tcaatttttg atatcgatac 3049621 ataatcctgg ttcatcatcc aggtaaacca ttgagaatgg gacaaatcct ttgtcagcgc 3049681 ctgaatctgt tttatataat caggaaggtt gttaaacagc cctgtcacct gtgcggtgat 3049741 gataggtccg actgacgctg aaataaaggc aagcaaaccg ataaacagta aatagatcaa 3049801 tagaatggat aatgtccgcg gaattttttt ctcaagcagg cggacgaccg gattaaatat 3049861 gaaatacaaa attcccgcaa ttagcatcgg gaaaaacaat gtcgagataa aaacaataaa 3049921 cggctgaaat acaaatgaaa cttttgttgc tacaaaaata atcagcaaaa caaataaaat 3049981 ctgcaatgtc caaaaatgga cttttgattt caacaagctt tgttcctcct agtttttctt 3050041 tgtctgtcag ataaaagaac ttatacccca tcattgtaac aaaaatgaac tcatatcaga 3050101 actcttaata taatgaaagg agtgttggtg atgaaggccg tgacatacga tacagattca 3050161 gaactggctt atatctatgt tcttcctccg aaaaagaaca ggaatgtacg gactgaggag 3050221 ctcagagtca atgattgtct cctgctggat atcagccaag atggcaaaat cgccggattc 3050281 gaatgttttg gtgaggcagc acacctctgt gccccatttg ccgggaaatc ccggctgtat 3050341 gtaaaagatt cagacggtta tcattttcgg gtctgccagc atgcttcagt ccgttcctgc 3050401 tatacggtgt accgtgtcac tttctgtttt tcagatggtg actatcagga atttgccggc 3050461 tttgaccttg atggaacaat gtatcatagt gcgtttttac agcgcttaac tgaaaaatag 3050521 gacgtcctgt tgtacgccta tttttcatgc gcaagcactg ttagacccgc tcactgtaat 3050581 ctggggtgac ggaaatcatg tgctggattc tgatcaaaca aacagaattt cgggctcctt 3050641 caattgtgat atggtcaggt tttacatcga tcagtctgcc tctgaccgta tctcgtactg 3050701 tctgtataac gaaccttgag ccgatgagct ttttaatggt ctgatagaca taaggatcga 3050761 ctaaagagac cagttgcgga ctaccttggt tgaccatact tttatcccct ttgtgtgttt 3050821 tatctcagct tatgccgcgc ttatggataa tgacacaggc ttacctgata aaacaaaggg 3050881 gtgcggagat tttaggagaa tacgtttgga ggcgggtgta aaggaagtat cgatgaagcg 3050941 gagacagcga agaaagctgg cgctgttccg tacttataca ggctttatca cggatgcctg 3051001 ggcttggtcg attaattggt ccagcttttc tatttttttt cgtgcggttg aaggatcaat 3051061 ttggcggtaa tgatggtggc cgcccggctc ttcatccagt tcgtccgctt ttttgacaat 3051121 ctgctgcagt gtgtttttat ctaattcgcc ttcaggcaaa taggaatctg tatgaagcaa 3051181 aatggctagt gcaatctctt ttgctgcttt cggttcctcg ccaagccgaa tcagaagttt 3051241 atgcgcccgt tccgcccctt taatggcatg aatgtcattt cttttgtatt tctcataatc 3051301 ccactttccg tctgtatacc attcataatg gccaatgtca tgaagcagtg ccgcttttgc 3051361 tgctaaatca ggattaatgt cagccttcac agacagcctg tatgcatgat aagcgcaggc 3051421 aatcgcatgt gccacgccgg aacgctgaag atatttttgt gcaattggat gggtgaaaac 3051481 atccattaat gtaacctttc tcatggaaac ccctccttta gatattttta gaatcctaac 3051541 ataatttgca gagaaactca attcttatgt cacatcattt tgatcttctt atcatcattg 3051601 ttatacccta aaagcaacgt ttcagtcagt atatgcggct gttcaataaa atgcgctggc 3051661 tgcagccttt tgtataaaaa aaagagcaga aaatatctgc tctacaaaaa ctctttaata 3051721 tcataaatgc ggccgttttc cgtccctttt tctagtaaag aaagcagcgt gccggcaata 3051781 aagtccggac tgcgaaggct tcctgtttca tttaatttcc ggaatcgttc aatgtggtgg 3051841 aaatcctttt tcgatgaaga acggatgacg gcctgcatct cagtgtccat cactccaggt 3051901 gagaacgaaa tcatgttcac cggcagctct tcatcctcct gttcaaatcc gaatgtcctc 3051961 gtaaacatgt cgagcccggc ttttgaactg caatacgcgc tccatccctt atatggattt 3052021 ttggcggctc ctgaagtaat gttgacaacc gtctttttgc cgctgtatga agcaaaccgt 3052081 tttgtaaaca gctgactcaa aagcacgggc gcagtcaggt tcagctgata atggcgctga 3052141 agctcgtcaa gagacgcttc gccggcacgt ttgatcggcg ttaccattcc ggcgttatta 3052201 ataagggtaa taccagaata acgatctgaa tcgatggatg agagcaatgt ttcaaattgc 3052261 tgttcagctt cttcgagatt gatgaggtct atttgatgct gcgttagttt tttgtgagag 3052321 acatctgttt tcgttctgga taaggcatgg acttcatgcc ccttttctaa agcctgtaat 3052381 gcaatggctt gacccagccc ttttgacgct ccggtgatga tataaagttc cattggaaac 3052441 ctccttttcc gttattattg tacggcacct cttttacaca acacaagcac gcggcctacg 3052501 ccttcttgtt ttcctgcgct gtgacttttg ggatgaggaa cacgatgcct gcaattccga 3052561 gcaggatcag tacgacatag atcatcggca gcagcaatga tgatgtttct tgttcatctt 3052621 ctgtttccgt tgatgatgtc tttgtcattg gtttttcagc aaaagtaatt ccaagctgtt 3052681 tcgactgggc cgcaatcgtg ttggaatcct cggcatttgt tgatgtaaac aaatctttta 3052741 tcagctcggc gtccttgtcc ttcggtttat caaaagtgat atccttttgt tcctcaggca 3052801 gttctgtttt ttcttcatag taggtatctt catgcaaata attcgtatcg atttcgatgt 3052861 cttttttctc atactggttt ggcgcgacat ctgtattttc ttcagtttgg gcagccgctg 3052921 cagagggtat gaaaagggaa aaggagagca tacaaatcat gatccccttt tccatgctgc 3052981 gatcacgctt catacgtttc atcgctttct gctgtgtgtt cagccatcaa ccggataatc 3053041 agcggcagag ccacggcaat caccgtaatg atcagcagaa ctgttattcc cattgtaaac 3053101 aagtgcccag taccgtactg gatgtcgata tatactttcg aaaccggatc ttcaaatgta 3053161 aagttcggca tgatcaaatc aataagcggt gcgacataga ataggatcat tgctgctgaa 3053221 gcaacccagc cagggattga tccgaatctg aatgccgtcc ggatgaaggc agagcttgcg 3053281 accagcaata gaatcgtaaa caccgaccac ttaatcgtct gatcgtccgg cagtgaataa 3053341 atattcaagc cgaacaagct gatcataagt ccgacaagga tattcagaat tccgaataac 3053401 gctcctttga cgagaagcgg tgcgttttgg taatacgagc tgaaatagcc gattaacaga 3053461 ctgctgatca acacaatgac aaggatgaca accggaggta ccgtctgaat tttttcttcc 3053521 ggaacctctc cgctgatttt aagcggattc gctaagtaat catatacata gccattgttt 3053581 tgcccgtcta ctaatgtatt tccgagtatg ccgtatacgt catttcgcac gagtttcgtg 3053641 gaggcgacat ttttccccca gttgttgttt aaggtgtcgg ctttcgcttg aacatcatta 3053701 acgctttgct gcatgttggt tgtgtaatca atgatgccgg actggcgatc agacaatgaa 3053761 cccatcatgt ctgacatttg cagcacttcc tggccgaccg tatcttggac actcagtgcc 3053821 atggtaccag acagcccatc gttgctgaac gtcgcagatt cctgtgttgc gcccgttaca 3053881 agctgttctg acgcttttgc ggcactttca gagattttcg tcagttcgtc gagaacacct 3053941 gcttgagagt cacggatata gccgctgtag tcgtccgcaa atttggtcat gccgtcgatg 3054001 aagctgttaa tatcctcatc tgtttgcatc gtgttgtttt tgagagcttc ccagctggct 3054061 gattcttcag gtgtgagagc caggactgat tggacgttgc catcttgctc ttggatgact 3054121 tcacctttaa taatagtcaa agagcctaga tccagattat catttagcgt agacttatat 3054181 aaatttaaag agttgtaata cttcatcaag ttagaaatat tatcagtttc aattctactt 3054241 gaaaaaattg aacttagttt ttctttctga tctatatagc ctctactctg caaagtttgt 3054301 attatttcgt cttccaaatt gtatattaac ctataagcat cattgacatt attatcaaaa 3054361 tcaaccaact tttttgttaa gtcaccaatt tgatcattta attttgaaac tgttttattt 3054421 aactctttaa tttcttgatt taactcatca atatgtttct ctagtttgtt gttatgttcc 3054481 tcttgttttt cttgaagtgc attttctatt tcctctaatt ttatcgctgc ttcgttcaga 3054541 cgtttttttg cacctgaaat atcagtttca ccgtcagctc cgtcaccctg tagcccatca 3054601 ctttgatttg agccatcgtt ttcatctgcg agttcaatca aagagaaatc tgttttagag 3054661 gttcctgtat tctccgtgtt tgtatcttgt tcaggaacgt tttttgaaga ttcttgatgt 3054721 ttttgtcccg tttcaatgtt agtttgaaca tcattttgtg atccattatc ttgagtaccc 3054781 tcttctgatg agccagtatc ttcatttgtt ggctgatcat cggatgttgg aatatcattc 3054841 gacggttctt cagtattagg agaatcatcg gttgatggtt cttcagcatc gggtgttgtt 3054901 ggtttttctt gttcaggttc ttttaaccct tcagagatat ctttaatttc agttgcaaca 3054961 tttttgagct catcccgctg cttctctaaa tccaatttta tatcttcaat atcttcctta 3055021 tctgtgtcat ctttattatc agatgtgtct tctccatctt ccttttcgtc gctttcctta 3055081 ggtttaagta aactaaggcg gttcttcccg atattctctt gcaattgatt taaattttga 3055141 tatttaatag cttcatattg acttttatat cgagatagaa atgcattaaa catgtcattc 3055201 tcaatttttt tcatacccat ttcttgcaat ggcacttgat tttgccttaa cttttcagca 3055261 ttgttcaacg caaggtttgt cagtcctatt tgtgtcttcg cttggccgat cccggttgcc 3055321 aatccgctca tgcgttcgct gaactgattc gccttttgct gtgcctggat ggcatccaga 3055381 cctgtccgga tttgctgctg tgttgaatcc tgggctgcca aaagcagctt tttctgattc 3055441 tcttgatatt ctttgtacct ttcaactgta tcaatgaatt ctttcagcgt gtttttggct 3055501 tcctccgccg tagaagcttt ttcttttgtc gtgccttgcg cttcattcat tgatttcttc 3055561 agctcatcga ttaagtcttt ttgctgtttg atttcacctg ctaaatcatt agagcttggt 3055621 ttgtaaaagt tgtacatgac attctggaat tcagattctt tattgacgat cttgtcaaat 3055681 tctcctctga tgttgtccac tttttgcgaa acaaaattcc agtataaggc cgacattttt 3055741 ttgttcattg tcttttgggc atcctcaagc tcacgctgaa ctttttcttt gttaaccgca 3055801 ttcaggttat cttgaatgct gaattcgagc gttgcctttt gaggatggtc tttgtcatag 3055861 ctcaaaatgt tttttgagaa gtctgaggga atgtagacaa tcgcatcgta tttctttgaa 3055921 gcgagaccgg tctcggccgc gcttcggttt acgaccgtcc acgaataatc aggacgttca 3055981 cccagaacgg ccgctacttc cttgccgaac tgggcggatt tgtcctcttc atcagacttt 3056041 acctcatcac tcaatacgcc tgtgtcttca ttcaccaccg cgatttgccg ggtagaattg 3056101 actgcttttt tcgttgggtc gtctccgata aatcggaaaa acaacaccgg cagcagcaaa 3056161 atgatgatga cggcggatat taacttgatc aagctttttc gttgttctgt catctagcac 3056221 tctccctttc agcagaacat aaaggaattt gaactttttg ctccttcccg ttttccacaa 3056281 catatccgaa gcccggctga atctcaggct cctgtctttg gtacgggaga ggaatgacat 3056341 tttgctcaga ctttttcatc agcagaatcg cgtggcggat ttgcttcatc tcagtcgtca 3056401 aggagtcata gccttttgag aattcgctgt ggtttccgcc cgggataaag ctgaacccaa 3056461 gatgagcgta tgatttcatg aagttagcga gacgatcttg tattctcgta tcaatcgtct 3056521 gctggaatct cgttatcccg tcaatcatca gcacgacttg tgagaatcgc agattttgtg 3056581 cgtctccttg gcggacggct tctacataca tggcttctct tgttttgaaa atgtcttctg 3056641 ctgtttcaat ccactgctca atatcttctt tcgtttccaa atatgaaaca tctgattcct 3056701 tcgcataatg agataagccg cggtcaatcg agtcaaacag gccgatcatt tcggtttcat 3056761 catcaatcag atgttcaagc atgactttta ggacgtttgt tttcccgcgc tgagtttggc 3056821 ctaaaatcag gcagtgctta tgcttgccca aatcaaaata gactgggctg actgtttctt 3056881 catgaagccc gatcggtaca gataaaggct tgcgttccag cttgaagcgg atagacaatt 3056941 ctctcgtcga caagctctca ggcagcatcg gaatcggtgc cggctgctcc attgaagcaa 3057001 atcgcccttg aagtttctgt acgtctgatt tcagctcgtt gaacatgccg atatcatcat 3057061 cggcgtcaac aggcaggaac atttgcgcga aataaagctc ttccttttga atgatgacgc 3057121 gtcccggaat cggctcaaga ttgaatttcg gacggccgta aatggaatat ccttctgatt 3057181 gatccatgag ataatggaca atctttgttt tcaagttatt taacaatgac tggcggacag 3057241 cattcacccg cgttgctgtc agcataaagt agatacccaa gctttgtccg tctctggaaa 3057301 gctggacaaa ttccgattca agctcatgca tctcatcctt gacaatgtca aagttgtcaa 3057361 tggtgataaa aatgaatgga agctcttctt cgctcagcgc attgtacatt ttgatgtggc 3057421 tgatttcttt ttcccggaac aaacgtttac ggcggtcaat ttcttctttg atgcgaatca 3057481 tgaacttttc aattttcctt gactggtcca tcaggaagta atccgcggta tgcgggagct 3057541 tcgctaatgg cagcagcgtt ccgtttccga aatcaaagat atagacatga agctcttcag 3057601 gtgtgtatac gtccgcaaaa ctcatcagga acgttgcggc tgcaatcgat tttccgtagc 3057661 ccgaagagcc gaagatgccg atatttccat cttccatcat cttataagca attggcgcct 3057721 gtctttgcag atcaggttca tcgacatacg caaagtggaa atggtctttt tcgtttgaag 3057781 ggaaaagagt gcgcggaata cgttccgcaa gcggcggcag ccaagggctt ggcagcttct 3057841 cgattcccat ttcatcttgg atgcgttcaa tttcgtcaac tacagcttcg atttcggttt 3057901 gaacgtcttt tttcgcgtta tcttcggtat caacctcaga aagcgggatc agacccgtat 3057961 ctgtgacgat cgcgatttca tcctcggtac cgtagacttc ctctaagtaa ggcgccccgc 3058021 tccatgcaga ttggaacagc tcatacactt cattgtttcc gacctgcaaa tagccgcggc 3058081 ctgttacggt aatgtttgcg gcatcgctgt ttttcaaaat ttctttactg tcggtggcat 3058141 cctggacctt gagcgctact ttaaagcgcg agttactcca gatctggtcg tcgatgatgc 3058201 cgcctggctt ctgtgtcgcc aaaatcaaat gaacgccgag gcttcgtccg atacgcgcgg 3058261 cactgacaag ctccctgata aaatcaggct cctcgctttt cagctcggca aactcatcag 3058321 aaattaagaa caagtgaggc atcgccactt ctgctttccc ttgcttgtat agctttgtat 3058381 agtcattgat gtgattgact tgatactggt caaacaggcg ctgccttttt tttagctcgc 3058441 ttttaatgga agcaagcgca cgcatactga agtttttgct tccttcaata tttgtgatcg 3058501 tgccgaggag gtggggaatg ttacggaacg gctgcgccat tcctccgcct ttatagtcaa 3058561 ttagtaagaa agccgcttca tgcggatgaa aatgcactgc aagtgacaag atgtaggtct 3058621 ggagaaattc acttttccct gatcccgttg tccccgcaag caagccgtgc ggaccgtgtg 3058681 ctttttcgtg aaggttcaga tacacaatgt catctttccc tttatagccg atcggcactg 3058741 acagcgactt cgacgattca cttgtcagcc atctttgctg aatgccgatt tcttttactt 3058801 ccttcgcatg aaaaagctcc aggaacgata ccgtttccgg aatggaattc gtaatgccga 3058861 cctggtggtt cagcgtccgc agtgtgcgtg aaaaccgttc gttatcctca cgctgatgat 3058921 gatcgagacg gaacggaatt cttaccgctt ttttcttttg tattaaaatg tcgccttcat 3058981 gctcattaat gtagcggaca agagttgtaa tgttttccga caagctttcc tttgtttctg 3059041 cagcgacaat tgtcgagatg cccagatgct catgctgccc ttctaaatat tcgagaatga 3059101 catgctcaga gatcagctgc tgattcgtga tgacaaatac aaaatgcggt ttgaactgca 3059161 gtttttcttt gtcatcttcg agatcacgct ctctgatcaa ttcgtaaagt gaagacagga 3059221 gctgatctcg ggtttgctca ttataaataa atccttttgc ataaatatgg ggcatttgaa 3059281 attgcggaag ccacttcatc cactcccagt ctttatactc ttcttcatga aaaataaata 3059341 cgaaacgcaa atcgtgatag ctgttaaaga acgacagctg tccgattagc tggtgaatct 3059401 catttttcac aatttgtgat ttaccgacaa gccccatcgg accttctgcc aaatcgaccg 3059461 tcaccggcgc attacggata tctttataga cgcgttgcat gtgctgcgat ttctccatga 3059521 ggtcatcgat atcacgattc gccaagtctc cgccactcat attgatttca tagcttgacg 3059581 gaactgttcc cgtcccaagc cgcagctgga gataatcctt gctttcaagt gatttttccc 3059641 agatccggtc actgatttca cttgttaagt atttcatttg ttcaaatgaa ggaaagtgaa 3059701 attcaagaac ctgcttttgc ttttcagcaa gtgcctgaag ctctttccgc ttattgtcta 3059761 agtaaagctt atatacacgc tcccgttttt cctcgcgttt tttccgctgg tttttatcac 3059821 ggaaatattg cactgtcgag gtaatgagag tcatcataaa catcgccaaa gaaacgagta 3059881 taaatatgcc gcgcggctgg atgatggcaa ctacgcccat cacgatcagc atcacaagcg 3059941 gaggcaggat gacgagccac agccctctgt tggtttgatc gctctcctga gagggaaaac 3060001 tgaaagaaac gcggtcatcc ggcagatcgt ataccatccg cggcgttctt ctgtactgcg 3060061 gatatttttt ctgcatctct gtactcggtt tgaccgtttc tgttaacgct gtttcaaact 3060121 gggcataatg aacaatttct aaaaggtctt gttccgtcac cctcatttgc gtgaagttcc 3060181 agaatatttc atcccccggc ttgagcggcg tattggcgtt gattttctct ccgttcaaga 3060241 agatcgttcc gctttcaggg cggaccgacc agctgccgcc tgcacggagc aaagaaaacg 3060301 tgctttgttc tgcaaatgca aaatcttgcg gattcagata aatatctgca ttcgtttttt 3060361 ctgaggaaca tacaatttca tcccgatttc ccgtaaaata aacggatttc tcaggttcac 3060421 tgcccgtcaa tatcaagcgt atatcctgct gatccgtttg gagagtaaat gatatatccg 3060481 tctcaatcgt gccgagacaa tcatttccca ggaaaacttc gtattggccg ccggattcct 3060541 ttcttttaag agaaatcact ccgctattaa atggaatggt gctgatcgta acagaatcct 3060601 tcacatcagg ccctatggtc accggatgag acgacgggag gttagacaga tttaattttt 3060661 gaacgttatt ttggtaaaaa acccataata gactcaaatg gcgaaccccc ttacggccga 3060721 atggcagcat gcgatgacct gcgcttcatg tctcacgtta tttgtcatct tttttctcat 3060781 ctttcttttc tgtttctttt ttctcgtctt ctttttcctt ctgttcttct tttttcgctt 3060841 tttcctcggc tgcggctttt tcttctgccg ctttctcttc tgcttgtttt tcttcgtctg 3060901 tttgtgtctg ttcttcgctt gtatcgacta acgatgtttc agaattagac tgtttatttt 3060961 cttgacgttc tttttgggct ttttcaagct cactatttac tgaatcaagt tctttttgta 3061021 tgtcttcatc atttgtatcc tcagataaaa gctgctgttt atatttagct agggcaaagt 3061081 aaatataatc attgtattcc agcttacggc cgatactgat cgcttctttg tattctcctc 3061141 gaccataatc aatccaatat aagaaatgct gagggtctga ttgaagggtg actaaattat 3061201 tttctatatt tttggttttt gcactcccca ggttttcgac ctcaacatag gacgtcgcca 3061261 gctgatactg caccgattca ggcaggcttt ccgcatcgta cttggacagt gtgctgatga 3061321 cttcactgta ctgcttgttt aagaacgcac ggttgctgtc cactatcgcc tggtgctttg 3061381 gctgcgcgaa aaataaggcg tacatcgaat aaataagtgc cggtacaagc aaaacaatga 3061441 gccccaggcc gatatatcgc tggatgttcc acttctttct cgggatatgt atgtatgttt 3061501 ttgctttggc ttcgagctca tcaatatggg tttgaatcag ctcgagcaaa tcatcatagg 3061561 attcagcatc taatatcgcc tttgcctctg cggagaacgt cagcgtttca ttgaatttca 3061621 ggtagtcttc aaacgcaaaa gcgccgtcaa ctgccaaagc cgctgccgct ttcagctcct 3061681 gccatactct ttcctcatca cgctcgtaag gaggaatgct ttcttttact ccataatgga 3061741 gaaaataagg cgtaagccct ttatcgaata caatgttttc aggagcgaca atcaaattca 3061801 gcctcgacag attgtgctgc tgtacggctt gaacaagctg ataggcaaac tgccatttac 3061861 tttttttatc cttagctttc atgaagcgga atgctttata ggaggaggga ggttggattg 3061921 tgatgattac ttcatcatcc gtcacatcga tttctttatg aaaaaatgga tttatatctt 3061981 tgatcacgtt agcttcaaga ccgtcgagaa gctttatttt ttcccgttga aaggtaaatg 3062041 tatagccggc atctgttttc tcggcaacag cttctaattg gttttctaaa tatgattttt 3062101 gttcacctga cattcaacca gatcctttca taatatttca agccggtctc cgtttgtaat 3062161 gccgcaatca gacagcttgc attctccgga aaacacctta tccttgttca ccactctgat 3062221 ccagtgccct tcgcgcggag gcatagatac gctttgggcc tgccaagcaa tatcaattac 3062281 ttttttcacc gggtggtaat ctgacaatct gagatcaaag acactgccgt tataatgttt 3062341 caaatctatt gtaatatcaa tatacattta ggatcaccct tacatagaaa gagcgccgtc 3062401 ttcttttgaa tcaggcgctc cttccctttc atactgttat ccgcggattt gatttgcgat 3062461 gtcttggtca gtagactcaa gtgtatttgc tgtttgatca agctgctgat tcacatcttg 3062521 aagcaaatct gacattttga taaatgaagg tttgagctgc tcgtattgat ctgcgaacgc 3062581 ttcgcttgaa gcaccttccc acatgctttt caaatcagag atcattcggt ttaaacgatc 3062641 aacctgattt aatacttctt ggctttcaac gccgtattgc ttcgccatcg ctcttagctc 3062701 ttcgggtgtg acacgaatta atcctgccat attcctcatt acctcctgtg ccatcagcct 3062761 aaatatgggc taattcactt atttttagaa cgtcattatt ataaaaacag tttttcggca 3062821 tagtcaaaca aatatgtttt aattttacaa aatgagtcca atggtttacc ccgaatcact 3062881 caaaaatgac atatactgta aagtaaatag gtttattttc ttaatcttct cttcattctc 3062941 cgaataatcc aaaagaccca aataactctc caactcccaa aaaaaacctt tcagaaaatt 3063001 tgatgctaca gcaccatttc tgaaaggttc agttttttct ttccttaatt agtcttgcct 3063061 ccgatgactt tcttagaaga ttaataggat aagctgtcgt attatatgag acatacactg 3063121 tcctgcaaaa aggcgattac accgccaaat gtatatagaa cgtttctctc atgaaattgt 3063181 ttttttgctt ctgttctttg ttgttgattt tcacaaacaa caacaatcat aataaaagga 3063241 aggggatgag atgtcaaaga gaaatcaagc acgaaaagta gggagattta tgaccatgcc 3063301 gaatgatccg tttaaatata gttttgacag acttgaagat gtggctgatc atatcagcga 3063361 cgttctgcgg tgcccgatca ccatagagga tgttaaccac aagctgcttg cctacagtac 3063421 acacagcgac tgcacagacc ctgcccggac gtctaccatt attggcagaa gggtaccgga 3063481 gaaggtgatt aacaagctgt ggaaagacgg gacaattcct gctctcttaa aaacggacca 3063541 gccgatcaga gtcaagcaaa tcgatgaagt cgggctgagc aatcgcgtcg ctatttcgat 3063601 ttggaaaaac aagcaagtac ttggcttcat atgggcgctt gagatccaaa aaacattgtc 3063661 cgatgaagat ctgctgacat tgcaaatggc agcaaaagca gtgaaaaaca agcttctcaa 3063721 acttcaaatc agaaaaacga aaaatgaaga acgcagccaa gaatttttct ggaaaatgct 3063781 gaccggacac atccatcagg aggatgatat ggcggatggg ttccataagc ttggaatggc 3063841 cgctccttca gagttttccg ttatgatcat ccgcataaat ggcgagctga ctgaaaaaat 3063901 cgaacagcag ctgcaatatt tacaggaaac gacccagcag gtttacgtgc tgctggcgac 3063961 cgtagattcc aatgaactta ttatattaac ctcacccaaa acagatcatc cttttcaaga 3064021 tttaaaacag tttgctttaa gtacgcaaaa acagctgaag gagcggtata aaatagaaga 3064081 cgtttctatc gcttttggcg gaatatacaa ctctatttct tttgtctccc gctcctatca 3064141 ggaagcattg tccgtcttaa aaacgaagga acggttcgct gaagagacca aacatctttt 3064201 cagcttttct gagttaggca tttatcaata cttagatgtc ttaaatgaaa aacggaaaca 3064261 ggcgggccat tataattact cgctttccaa actggaacaa tatgaccggg atcaccagtc 3064321 aaatatggta gagacgctag agcgctttat tgaagcggac agcaacgtga ataccgcttc 3064381 caagctgtta aatatacacg ttaatacgtt gaattaccga ctcaagcgga tcagccagat 3064441 cgctgaaatt gatttgaaaa atgtgaatca aaaattcacc atctatttag atatcaaact 3064501 tcggcacatg gatttgtgaa atttcacaaa tccatgtttt tttattttct taatcaaaca 3064561 aagaattttc caaaatatca agctacacta aaaatatcac atatacagga ggagacagat 3064621 atgatcatag gggttcctaa agagataaaa aacaatgaaa accgtgtcgc attaacaccc 3064681 gggggcgttt ctcagctcat ttcaaacggc caccgggtgc tggttgaaac aggcgcgggc 3064741 cttggaagcg gatttgaaaa tgaagcctat gagtcagcag gagcggaaat cattgctgat 3064801 ccgaagcagg tctgggacgc cgaaatggtc atgaaagtaa aagaaccgct gccggaagaa 3064861 tatgtttatt ttcgcaaagg acttgtgctg tttacgtacc ttcatttagc agctgagcct 3064921 gagcttgcac aggccttgaa ggataaagga gtaactgcca tcgcatatga aacggtcagt 3064981 gaaggccgga cattgcctct tctgacgcca atgtcagagg ttgcgggcag aatggcagcg 3065041 caaatcggcg ctcaattctt agaaaagcct aaaggcggaa aaggcattct gcttgccggg 3065101 gtgcctggcg tttcccgcgg aaaagtaaca attatcggag gaggcgttgt cgggacaaac 3065161 gcggcgaaaa tggctgtcgg cctcggtgca gatgtgacga tcattgactt aaacgcagac 3065221 cgcttgcgcc agcttgatga catcttcggc catcagatta aaacgttaat ttctaatccg 3065281 gtcaatattg ctgatgctgt ggcggaagcg gatctcctca tttgcgcggt attaattccg 3065341 ggtgctaaag ctccgactct tgtcactgag gaaatggtaa aacaaatgaa acccggttca 3065401 gttattgttg atgtagcgat cgaccaaggc ggcatcgtcg aaactgtcga ccatatcaca 3065461 acacatgatc agccaacata tgaaaaacac ggggttgtgc attatgctgt agcgaacatg 3065521 ccaggcgcag tccctcgtac atcaacaatc gccctgacta acgttactgt tccatacgcg 3065581 ctgcaaatcg cgaacaaagg ggcagtaaaa gcgctcgcag acaatacggc actgagagcg 3065641 ggtttaaaca ccgcaaacgg acacgtgacc tatgaagctg tagcaagaga tctaggctat 3065701 gagtatgttc ctgccgagaa agctttacag gatgaatcat ctgtggcggg tgcttaattc 3065761 acaataagct tgcagaaaga tttctgcagg cttttttatt ttttaaaagg aaaaaagaga 3065821 ccatttcacg aattatgact atgaagttga tcataaagga ggattcatat ggctgttcag 3065881 caatatggcg tgttaaaagg catagtatta gacatgaagc gggaaacaga tgatgacagt 3065941 cctcatttcc aagtcaaaat gctcggtgaa gagaatacgt attacaggtg cgccatcaat 3066001 gtgatgtcca gttctgagga atctgaagta ttgtatttgg ctgacgatca gtttgattcg 3066061 ggctcaatta ccatccttcc gaacatgccg tatggatata caaggatcaa tgaagcaaac 3066121 cgtgaagtgg cactggatta tgtgcggggc aatttgtttg acccgcggga aatgaagcct 3066181 ttgcctcatg aaatcacggg acctgataat gatttaaatg attttattga aacctatatg 3066241 aagaaagcac aagatgagaa aacgccggtt tatatattcg gttcaaaatt cggccctgaa 3066301 caggctgcag ataaaatatt cggctttacc ccgactaacg gaatgcacaa tatccatatg 3066361 aatcaaggga atgcaatgga tacccgctgg aaaaaagaca acggctcttg gcatgacggg 3066421 ggtattctga ttcagtttgc agatcagtgg gccgctgtgt ttttagcgtt tttatcccaa 3066481 tcttggtgta ccgatgaaaa cggaaaccct gtcagagatt gtgatcatac ccaaacgtct 3066541 gcgtaagata gaaaaagaga ctgcggcaag cagtctcttt ttgataagat tacacatttt 3066601 caacagtctt taggctgttt ggcctcatat cgctccaatg cgattggata tagtccaaac 3066661 aagcttcacg ccctttttgc tcatgaacga ctgtccagcc gctcggcaca tctataaaac 3066721 ccggccatag ggaatattgg ccttcttcat tgaccagcac caaatatgtg ccatccgcat 3066781 tttcaaaagg atttgccatt ctatttctcc tcccttattt attcaactct tccaatttga 3066841 cagcgagaac cttgccgatt tgagccagag gttcaggctg acataaatct ttatgacggc 3066901 agtcgatgtc gatttgttca atctgtccgt taatataagg cttccacgag tcaggttcaa 3066961 tcgggtcaaa ccattcagga atgattgttg atctgaaaaa caaaacattt ccgcggaagg 3067021 ttttcggctt ataggaacct aaaatgccga cagaatttac atacgtattc ttcaaattta 3067081 aaatgaccgt ttcatccagg ctcgcaagcg cactgccgtc acggcgaaga atctcaatcg 3067141 ccgcttcaaa atctagcggt ttttccccta agctgtctgg atcatacccg cctaacgcca 3067201 gaagggcaat aagcgcttcc tcatcatccg gtgcctcttt tataggaagg aagtggttcg 3067261 gataggcgtc cagcatcacc aacagggata cttcttctcc ttgattttgc agctgggtag 3067321 ccatcgcttg aacgacattc ccgcccaggg accagcccag cagatggtac gggccttttg 3067381 gctggaccgt tcggatttgt ttaatgtaat cggcagccat gtcatcaagt gttttcggaa 3067441 gctcctcgcg ctgcccgatt ccccgtgcct gcaagccgta gatcggataa tctgttccta 3067501 tattggtcat caaaccggca taacaccagc tgagcccccc tgccggatga acacagaata 3067561 aaggaggctt gtctccgctt gttcggagcg gcagcagaac gtcaagagcg ctttggcttg 3067621 atcccatttc aagtctttca gcgagcccgg ctacagtagg tgcttcgaac aagttgccga 3067681 tgctgagttc aacgccgagc gcttcacgaa tgcggctcat gagctgtaca gcaagcaagg 3067741 aatgtccgcc taaatcaaag aaacggtcat caatgccgac acgcggcaag tgaagcacct 3067801 ccataaagag gtcacagaga atttcttcct gcggcgttct cggtcctcgt cctgtcactg 3067861 ccgctgcgaa atccggagcg ggcagcgctt tacgatcaag ctttccattc ggtgtcagcg 3067921 gcaattcttt catcgtcaca aaggcagcag gcaccatgta atccggcagt ctctcagcag 3067981 catatctgcg cagttccgcc gtatcaaatg tttcttccga agggatgaca taagctgcta 3068041 accgtttatc tcccggctga tcctcacgaa cgatcactgc cgcatcttca agctgcggat 3068101 gctgaacaag cgcggcttca atttctccca attcaatccg gaatccccga attttcactt 3068161 gatggtctgc acggccgaca tagtcgagag aaccgtcagc gcggaggcgg gccacatccc 3068221 cagtgcggta catccgggtg cctggaggac cgaacggatc agctatgaag cgttcagatg 3068281 ttaaaccagg ccggcctaga taacctcgtg ctaaccccgc tcctgataca tacagctctc 3068341 cggcaacacc cggcgggacc ggctgcaggc gttcatccag cacgtataca ccaagatcgg 3068401 gaatgccgca gccgatcaag ctgtttgccc gtaaagctgc catgcttcgg tctaattcga 3068461 tatagctcac atgcaccgtc gtttctgtaa taccatacat attgataagc tgcggtctat 3068521 tttcagggtg gcggttgtac caatcctcta aacggctgag ttcaagcgct tctccgccaa 3068581 aaatgacata gcgcagactg agtgcctgtc cgagatccgg ctgttcccgt tccgcctgca 3068641 taaactgata gaaagcagac ggtgtctggt tcagaacagt caccccctct ttgacaagca 3068701 ggcgcagaaa cgcttctggc gatctgctga cgtggtgagg cacgattaca agacgtccgc 3068761 catgcagcag aggaccccag atctcccaca ccgaaaaatc aaacgcatag gaatggaaca 3068821 tggtccagat atcacctgag ctgaaacgga accagtgctc ggtcgctgca aataaacgtg 3068881 ttacattttg gtgaggaatc atcacacctt ttggaacacc tgttgagccg gatgtataaa 3068941 tgacatatgc cgtattcaaa ggggaaagcg gctgagtcct atccttattt tttggattac 3069001 ctgcagggta cgtgtttagt ttctctgcca gctcgggatc atccagcacg attttcggca 3069061 cgttttcaac tggcggaatg tgatttgcag ctttagtgtt cgtcatgata aacgcaggct 3069121 gtgcatcttt tagcataaaa gcaattcgat cagccggata atccggatca agagggagat 3069181 aagctgcccc ggcctttagc accgccaata ggccgacagc catttccaac gatcggggca 3069241 gtgccaatgc cacaaattgc tccggcccga caccttcact aatcatcatt cgggcaagcc 3069301 ggtttgctct ttcattcagc tctgcatagc tcagttcctg attttcatat acaacggcaa 3069361 tggcatcagg acgtaaagca gcctgcttct caaattgctc tggcaaacat gcgtgcggaa 3069421 tcttttcaga tacactttgc caatcagtca ccatgctgct gtgttcctct ggcgcaagaa 3069481 tatccagatt tccgatttgc tcgtcaggat cagactcggc agcctccaac aggcgcatca 3069541 atcggtcagc aagagcctga gcagtttccc gtttgaaaag atcagtgctg tattcaagca 3069601 gtccttccat tccgtttggt gtcccgtcag caaggcgatc ttcactaatt tccagcgtca 3069661 aatcaaactt ggcagaaccg acactgttga ttcgcaggct gctctccata tcaggaagat 3069721 gcagttcagc gtccggtgtg ttttggaacg caagcatgat ttggaataaa ggatgcgtcg 3069781 cacgcgaacg agccggattg agcacctcta caagtctctc aaacggcaga tcctgattgt 3069841 cataggcggc cagattcact tcccgtactc tgtctagaag ctcacgaaag cttgggtcac 3069901 cggacgtatc agttctgagc accaatgtat taatgaacag ccctacaaga tcgcccagcg 3069961 catcatcatt ccgtcccgcg atcggactgc cgatcggaat gtcggtgccc gccccgagcc 3070021 ttgtcaataa agcggcgaga ccggattgaa gcaccataaa caggctcacc ctatttgcgc 3070081 gagccagctc ctgcaatcgc ttgtgaaact cgggctcaat acgaaaatga atcgtatctc 3070141 catcatgact cggctcagcc ggacgtgaat aatcggttgg cagttcaagc tgatcaggca 3070201 ggtttttcaa ggtttctttc cagaaagcaa gctgtccggc aatcaagcta tttggatcat 3070261 cctcgtttcc aagcagttct tgctgccaaa gcgcatagtc tgcatactgc acagcaagag 3070321 gcgcccattc gggagatcgt ccgtggcagc gagccgcata agctgtccca aggtctctgg 3070381 tcagcggtgt taaggaccag ccgtccccga caatatgatg gacgagaaga agcagcacgt 3070441 actcgtcagg accgatcaca aaaagctcgg cacgaaaagc aggttcagct gcaagatcaa 3070501 agctgtagcg tacagcttcg gcaagccgat cagaaagctc cttctcagca atttcagtaa 3070561 catgtaactc gggacaggct cgatcggcat ctaaaatatg ctgataggat gtcccctgtg 3070621 attcagggaa gatcgtccga agactttcat gacggcagac gaggtcataa agtgccgctt 3070681 tcagcaatcc ttgatccaac tcacctgaca aacggacagc aaccggaata ttataagtag 3070741 gactcggtcc ttccagacaa tgcaggaacc atagccggcg ctgggcaaat gagagcggga 3070801 tcttttcagg ccgctcagct ctctgcaaag cgggacatgc actctgcgcc aaatcaagat 3070861 gggcagcgag tccggctact gtcggttcgt caaagagctt ggcgatacca agttcggctc 3070921 ccattacctc gcgaatgcgg ctcatcagac gggctgcaag aagagaatgg cccccaagct 3070981 cgaagaaact gtcatcgata ccgacgcgtg ccaaaccgag aacctctgca aacaagtcac 3071041 acaatatctc ttcctgagga gtccgcgggg cccgatcact gacagatgtg ctgaagtctg 3071101 gtgccggcag tgctttccgg tcaagcttgc cattaggtgt taacggcagc tcgtccatct 3071161 ccacaaacgc cgacggtacc atataatcag gaagactagc ccccatataa cgacgaagct 3071221 ctgcagtatc aatagcagca tcagcgacta cataagccgc caatcgtttg tctcccggct 3071281 gatcttcccg tacgacaacc gcggcctgtt caatgtgcgg gtgattggca agcacggcat 3071341 caatttctcc aagttcaatt cggaatccgc gaattttgat ttgatgatcc gcccgcccga 3071401 tataatccaa agacccatcg gcgcgccagc gggcctggtc tccggtccga tacatccgag 3071461 ttcccggcgg tccgtatgga tctgcaacga agcgctccgc cgttaaatca ggacgatgga 3071521 aataacctct ggccaagccg gttcctgcaa tataaagctc tccgacaacg cccggcggca 3071581 ccggctgcaa tccattatca agcacataca cctgcgtgtt ccaaatcggt ttcccaatcg 3071641 gaggaacgcc cttcagccct tcttcaagaa aagctgcggc agaccaaatc gttgtttcag 3071701 tgggaccgta taagttcgtg actgaacaat gaaggtcttg aagttcctgc aaaagaccgc 3071761 tcggcagcgc ctcgcctcct acaagcactc taagcccccg aagtttctca ggttcactcg 3071821 ttaccaaagc gtgccacagt gtcggtgtcg cctgcataat gttaatatcg aaattttcaa 3071881 tcatttgagc taatgcctgc ggctcacgga tcgtttcttt ctttgcgatc acgatttgcg 3071941 ctccgctaat cagcggaaga tataactcca atgctgaaat atcaaaagcg acagtcgtca 3072001 cagccaacag cctgtcttct tctcctagag aaaatgcctc ctgcatagac agcagaaaat 3072061 tgcttaagct tttctgtgtc acaacgactc ccttcggtct tcctgttgat cctgaggtat 3072121 agatgatata cgcaggatgg tcaagcgaaa ccgatacatc ctgattttcc ggcgaatagc 3072181 gttttataat ctcctgtgta acagcctgat caagcacaag ctcaggtaca gccaggtcat 3072241 caggcagact ggctgctatt tcctcagtcg ttatgatgca tgaaggtttc gcatcctcca 3072301 gcatgtaaga aatgcggtcg gctggaaact ccggatcaag ggggagatac gccgcaccag 3072361 tcttgagcac accaagcatt gaagccacca tctcagggga acgcggcagc gccaaagcga 3072421 caaattgctc cggaccaatc cctttttcga tcaacagacg cgcgaggcgg tttgcctctt 3072481 cattgagctt tcgatagttg acttgaatgt catcacacat gagagcgata cgttctggcg 3072541 taagaactgc ctgcttttcg aacatgtcct gaaggctgac cagcttctcg gattttgccg 3072601 tctcattcca tttagaaatg actttttctt tctcctctgg caacagaagc tccatttgcc 3072661 caatcagcat gtcctctccg gcagaagccg tttgcagcag ctgcaaaata cgctgctgat 3072721 gaagcttaat atcagactca ctgtatacct cgggattcgc atcaacatca attcgcagcc 3072781 cgctgccgtc tgttctgtca tatacattga ttgatagatc atcaacagga ccggctgaaa 3072841 gattatgcgt tgtgccccgg acgccggcaa agtcgagacc gtaatcaaac ggcataagat 3072901 tgatttgagg gccaaataat ctatgatttt ctcctatcaa tttcagatcg cgcctaagct 3072961 cttcatggcg atacttatga tgtcgccgaa tactgcggat ttcccgggaa atttgctgaa 3073021 tcagttcaga aaagctcatc gaagagctta ccgtcagccg gagcgggaga aggttcatca 3073081 ccatagccgg tacattcagt gacgcggacc ctatccgacc catcatgggc aggccgagca 3073141 caacatcctc agagccggtc atacggtgca cataaacagc tgacaccgca atcatgactt 3073201 catgccagct tcctgagaaa tagcgcgccg cttcttttaa cgcgtttaca tcagacggag 3073261 gcagatatgc cgtatgacga agaaaactgt tagatgttct tggcgcccga tcagccaagc 3073321 tcacaacttc aggtgcatct gcaaaacggt ccagccagaa ttgacgatcc ttctcatact 3073381 gctctgatcc gcgataatct gtatcctcct ccaaaatggc ctggagagac ccaaaggaac 3073441 ggcttttagc tgtttgtcct tttataaggg cagtatatgt acttgccaca cgctgggcta 3073501 tcagggaaaa accgaagccg tcgatcgcta tatggtgaat gcgctgatac caaaagaaac 3073561 gatcaggccc ggcaataaac agagcttcat tgaacaaagg ggcataccct aaatcaaccg 3073621 gctttgctaa atcagctttc atccagttta atgctgtttt ttccggatca ggctcagagc 3073681 tgacgtcaat gacgtgcagc tgtacatccg gagacgggtt tatcatctgc caaggcccgt 3073741 ccatattttc accgaagcgg acatgcagcg attccgcttc cttgatcacg tgccgcaaag 3073801 cttcttcaaa aagagcaata ttgactggtc cattgatttc tatatattcc gctgtattgt 3073861 agattggatt gtccggatca agctgctgag caaaccatat gccagtttgc gccccggtca 3073921 aagaatattg aagatctttt gtatcaggca tccgtttgtt taccctcctt ttataaataa 3073981 tccgcgtttg gcagcacttg ctggctgcga gttgtgagca atttctgcca ttcttcgatc 3074041 gttgggcgtt cagccaattc cacgaaagtc acctctgccc cttcacggcg ccattgttcc 3074101 accaatgtca tgatccttac cgaatcaaga ccacgatcga gcaaatcctc ttgatctgtg 3074161 atgtcttccg gtgtttcttg tagaagctca gcaatttgtt tacggatatt ctcacatgta 3074221 aacacgttct ttttgccagt gtttgctgac gttttttgaa cgtctgccgg cgcattctgc 3074281 agctgatcaa gaagactgtc agtcatcacg gtaaacgcac agcgtccagc cgcatattcc 3074341 agcgccattt gatgtttttc taatgaaaaa tcagcaactg catctcccac aaaaaaggct 3074401 ttaatatcct ccataaatgc ttcacatgct gtaacaagac agccgatatg ggcgtaaatt 3074461 cctgtaatga tcagctgatc gcgtccctct ttgcgcatca tttcaagcag attcgttctc 3074521 ttaaacgcgc tgtatctcca ttttgtcagc acaagatcat catcctctgg tgccagctcg 3074581 gttataattt tctcctcata aggaccgctg tttaatcccg ggccccaaaa gtctgtcagc 3074641 agcgcacggt catccggatt ttggcttccc ggctgtgcgg tatagacaac aggaatccca 3074701 agctgaacac attgattctt cagctttcgt atattcgctg aaagctctgt taccggagac 3074761 gctcccgctg tgaaagcatc aacaaaatag ttttgcatat cgtgtattaa caagacagcc 3074821 cgattcggat caggcaccca tgatactttg ttttgcggca tatcagatgc tgtcggcatt 3074881 tgatacggct gaatggcagg tatagccata tgaacacttc ctctcaaatt gttgttttat 3074941 tttttaaatc ctgcaagaag cttctcggaa atggcttcac ggagcgcttt tttgctgact 3075001 tttcctactc ctgtctgcgg gaaggattcg acaaattcaa ctcgatcagg gattttatat 3075061 gccgccagtc cgcgctctct caaaaatgct ttaagctctg cggcttttgg ggcttcatcc 3075121 cggggaataa tgaacacaca agatctttcg ccaagaaatt gatcaggcat ggagaccatt 3075181 gccgcatcat ggacagccgg atgcgccagc agatgatttt ctacctcttc agccgcaacc 3075241 ttttctcctc cacggttaat ttgatccttc gcccggcctt caacgacaat atagccgtct 3075301 cgtgtcagcc tgacgatatc acccgtacgg taaaaaccgt cctcagtaaa tgaagcggcg 3075361 ttatgctctt ctgccttata gtaacctcga attgtatacg gcccccgcgt cagcagatgg 3075421 cctgtttcac caggttttac gtcgcgatca tgatcatccc aaacacgcat ttcatcatat 3075481 ggagacatcg gttttccttg ggtgttgaca atgatctcct caggatcatc caatctcgta 3075541 taattgacga gaccctctgc cattccgaac acctgctgca gcgtgcagcc gaaaacagct 3075601 tttaccctgc gcgcggcttc agcactaaac ttggcaccgc cgacctgcag cacttgaagg 3075661 ctggataaat catcacggcg tgaggatgcc gcatccatcc ataccatcgc aagaggcgga 3075721 acaagagcgg ttatcgtgac cttttcccgt tcaattaaag gaaatgcgtc atctggactt 3075781 ggagaaggag ataataccac tcttcctcca gcgtataata cgccgagaac gccgggtgag 3075841 ctcagcggat aattgtgtgc catcggcagc gcggccaagt acaccgtgct gtggtcgagc 3075901 cagcagacct ccacactccg cttcaggctg tatatgtagt catcgtgggt cctcggaatc 3075961 agtttcgata gcccggtgct cccgccagaa agctggagga acgccacatc cgatgatttg 3076021 acttcaggca gttttacagg ttctgcatgc aaatcctcca gcggtaaaaa ttcctctgcc 3076081 tcacctgcga caatgatgtt tttcaaagtc ggcagcttgc tttgaacctg tctggcaagc 3076141 gaacggtagt caaaaccgga ataagcgtcg ggaatgatat atgcagccgc ttcagcaaac 3076201 tcgcaaaaat atgtaatttc actgcttcga tgagaaggca gtgcgaagac tggaagcgcc 3076261 cccagacgga aaagcgcgaa aatgacttca aaaaactctt tgatatttgg caactgcacc 3076321 acaacacgat ccatctgttg aatgccgagc ttttgaaatc cggcagccag gcgatcagcc 3076381 cttgtgtcaa gctctcgata gctccaatgg gtgtttccgc atgtaatggc aatgcgatca 3076441 ccatatttgg ctgcccggtc ccttaacaaa tctccaaacg tctcaccggc ccagcagccg 3076501 ttctttcgat aggtctcagc taactcatca ggccaaggcg taaatccttt cagcatgttg 3076561 tatccctcca gcaattcatt ctgttcatat gtgatccacg cccattgccc gcagcattgt 3076621 ccgaaacttt gcggacgtct cctgaagctc gtcctcaggc tttgaaccgg ccacaacacc 3076681 agctccagca tacaggcgga gtgagcgttc ttctgcttct gcacaacgga tggtcacgat 3076741 ccattctccg tcaccggcat cgtcacacca tccgaccatg ccggtaaaga aaccgcggtc 3076801 aaatggttca atgctgagaa tcgcttctct tgcaagatca gtcggtgttc cgcagacggc 3076861 tggcgtcggg tggagcgccg ccgccaattc aagtgcggtt acagacgggt cggaaagctc 3076921 tcccttaatc acgctggaca ggtgccacat cgtttccgtt ttgatcagtg aaggcttctc 3076981 cggaacctcc agcgtccggc agaaaggtct cagcgctgcc gcaaccgcgt cagcgacaac 3077041 cgcgtgctca tgaagatcct ttgcggaaga aagcaattca gctgcccggc gctggtcttc 3077101 aacaggatca ttactgcgcg gtcttgagcc ggctaatggg ttggaaacga cctgtgttcc 3077161 catccttgaa acgagaagct ccggacttgc tccgagcaat gttctgcggg gagacgtttc 3077221 ctcctgactg gacacgtctg cggcaaacgt gtagccatgc gagttatgct gagccagatg 3077281 gcgaagcaat tcatccgtct gaatcggttc aggcgatgtc aaatgcagcg atctggacag 3077341 gacgattttg ctgagtgttc catcggcaat gcgtgccagc ccttgttcaa caccattttt 3077401 ataatcctca ggttcaggaa caggctttat gtggtatgta tgcccagcct gctgttcctt 3077461 ttcctcatga tcaaattgaa gcggtcctga ccagcgcact tcttcaggta caacgagccg 3077521 cgctgctttt acttgatcaa aaggaacggc cccgacaaca agcggccggc tttgccctga 3077581 ttgttttgcc tgacgtaacg cctctgcaat tcggccagaa agggtttcca tttggttttg 3077641 cccgtctgcc tccggtacaa tttcacatat gcctttcgct aacagtacac gatgaggaga 3077701 cgctaagaaa aaggcgcccg gctgatattc atgaagcaaa tgctccgctt ttgtttctgt 3077761 tataacgttt tgatccaaca ttctcatgaa cctcctttaa attcagttac acgcctaagg 3077821 tcgcgccgcc atctacgcat aaattatgca tcgtaatatg ccctgcctgg ccagaaacca 3077881 aaaagagcac cgcatccgca atatccgaag gcttggctag ttttttgagc gggatccctg 3077941 ttttaaatgt ctcaagtgat ccttttatga cttgctccgc tccattctcg tcggcccata 3078001 atgaccactg catgtctgtt tccgttgatc cgggagatac aatgttgcag cgaatattgt 3078061 attctgcaag ctcaaggcca aggcatttcg taaacatcac agccgcagcc tttgaagacg 3078121 catatgccgc catagatgtt cttggtacac cggcagcatt cgatccgact gttacaatcg 3078181 aacccgatct tcggtccatc atatatttgc tgactgaacg cgaggcgtta aatacgccag 3078241 tcgaattcac tgagaacgtc gcctcccatt cctcatcgct aagcgaatgg atcagtcccg 3078301 ggcgaaggac acccgctaca ttcactaaaa tatcaatcgg ccccatttca cgttcgatgc 3078361 gcgccgtgat ctcgtcaatc gccgcgctgt ctctcacatc cgcaggaaaa gcttctgcat 3078421 ggcggccttc tgctttgagg ctgctcacaa ccttttccag cttttcagga ttataatcaa 3078481 ctgccgcaat atgtgcgcct tgactggcaa gcgtccgcgc aacagcttcg cctattcctt 3078541 gggcagcccc tgttataaaa gcaatttttc cctctatacc ctttgcattc atatcatcaa 3078601 ttcctttctt cgctctaaat gccaaacaga catccagcga aaaagactgc tgcgccttga 3078661 aaaacgcaat ctattgataa tgattatcat tatcaattat aaaaataatc atatccaaat 3078721 gtcatgtgac agtcaaatat aatttcagtg acaaatattt ttttaaaggc aaggctgagt 3078781 atgtctcagc ccattgatag atgcggtccg tcagggtgaa gcgcaaaacg cagcgccctg 3078841 ctgaccaaaa caggaagaac tgaaatatgt ccttctcctg aaaactcgca aaattctgcc 3078901 cgtatacctt gttcagataa aacggccagc cgctcataaa gctcccttgc attatcattc 3078961 atccggcttt tatgatgctg ctctaattct cctgcggcaa gcaggatatt gataggctga 3079021 ttgtttttct tggtgagaga gacgaaatgg tccgttttct tgagaataaa cggtttattc 3079081 caatgaatgg acggacttcc cgcgatatac gtttgaaacg catcgggctt tgttagcagc 3079141 acctgcagca cgaaaagccc tccgagcgaa tggccaaaga ttgtttgtct ttttttatca 3079201 atctggtaat ctcgttctat ctccggtttt aaatcctctt caataaatct gaaaaagccc 3079261 tccgctccgc catgctccgg ccattctctg ccgtcgggcc tttccggcag cttcgattgg 3079321 gctgttggca ttgtaaaatc ccggtggcgt gctgaggaga acggctccgc tgtctcatag 3079381 ccaatgccga cgatcactgc agggatcacc ccggtttttt cgggtcggcg tccctgtatt 3079441 cgaacggctt ccgtcatcgt tccgaagaca gaattggcat ccagcagata aatcacagga 3079501 taaccagcgg gtggcggcgg cgtactaggt ttcgagataa aaatgtgata ggtacggttt 3079561 tcattgcgtg aagacatcat acgcacttcc gtaccaggaa tcgtaaatgc gtttgatgtc 3079621 ccgccatttg tccggtctgt tgtttgttct ttcatgcagt acgacattcc tctccttaaa 3079681 ctaaaccgca atgtatgata atgattttca ctatcaacta gacacctcaa ataataggtt 3079741 ttcttccaaa gaaagtcaac tttttcccga ataaaaaagg caccttgatc aaataaggta 3079801 cctgcagact atcaatatgg aagtaaaaac ctaataaaga tgcgtattgt cctatttgaa 3079861 atagaacctt aatcccatgt aaacctttga ttttgccaag ggtcgcctct catgtgatag 3079921 ccattccgct cccaaaagcc agggtgattt tctttcgtaa attggatgcc gcgcagccac 3079981 ttggcgcttt tccaaaaata cagatgcgga aatacacccc gcagcggaaa gccgtgttca 3080041 ggggttaaag gttcgccatt atgcgcataa gccagaaggg aagtttccgc taagaaatca 3080101 tcaagcggca gattggtcgt ccagccctct tcagcatgta aaatgacgta gcccgcttct 3080161 tcttttacac ccgctttttc cgctatatca caagcccgca cgccttgcca cacattatca 3080221 agccttgacc atcccgtgac gcaatgaatg tcgtttttcg attcataccg tggaaaggct 3080281 ttgacatctt caaagcttag cagcatcgga tggtcaacca aaccgtatac ttgaagattc 3080341 catttcgtca tatcttcgta atatgggaca tctccggtat gaagcacagg aaatgaagtg 3080401 gtgacgtttt gatttggcgg cactcttcca gattgatcgg actgtcttgt ttttccgaaa 3080461 tacatatggg cctccttttt gttaacctaa tttaaaatca tgttgacaat ctttttgttc 3080521 tttattactc tatgattgtg tatgtcaacc taagggggaa caacgatgaa acaacgtaaa 3080581 cttcgtgcgg gagatatggc gctgattggc atgttcgccg cacttatggc tgtcggggcc 3080641 aacattacat cagtagcacc ctttttacaa gtagccggca ttccgctttc gatgcagccg 3080701 tttttctgtc tcttggcagc tttgcttctt ggcagcaaac gggcagcgat tgccatgatt 3080761 gtatatgcac ttgtgggatt ggccggagcg cctgtgtttg ctcaattttc agcaggcttc 3080821 gcaccgtttg cagggaaaag cggcgggttt attatctcat acattccggc agcatttgca 3080881 gcgggatggt ttttagaacg aaacattcag ccaagtaaaa ttcgatttct cattgcttca 3080941 cttatcggaa cggcgatcat gtatctcatc ggcactacct atatgtatct tgcactgaag 3081001 ctgtggattc atacgccagt gagctacggc acggcttggg gctttatgat ttggtttatg 3081061 gtaaaagata cagcgctggc tgtgatactg tcgtttatcg caccagcaat ctaccgctct 3081121 attcataaag caaccggctt taacagaaat cacatatcat ctacgtaaaa accgttctat 3081181 tggacggttt ttttatcata acgagaaaag gctccccagt aaaggggagc ctttttccta 3081241 taaaacaagc gctgcaatcc agccaaagat gacaagcgga atattataaa atataaatgt 3081301 cggcacacaa gtatcccaaa tgtggtgatg ctggccgtcc gcactcaaac ctgaagtcgg 3081361 cccaagcgta ctgtcactgg caggtgaacc ggcatcgcca agcgcagcag cagccccgat 3081421 aatcgcaatc gttgccatcg ggctgaatcc aagctgcatg catagaggca cgaaaatggt 3081481 tgtgataaca ggaatggtcg caaaagaaga tccgatcccc attgtaatta ataagccgac 3081541 aatgagcatc agcaatgcgc ccaaggactg actgtgtccg ataaaaccag ctgacgtttt 3081601 gaccagtgac tcgacatctc cggttttcgt caatacgttt gaaaatccgg ctgcaacaag 3081661 catgacaaag ccgataaagg ccattaaaac cattccatca gtaatcagtg agtccgcttc 3081721 atcacgcttc atcacaccgc tgacaaacag aacaatcaga ccagcgagcg cccccataat 3081781 cattccttct actcccaaag tctgagataa gtaaagctgg acgccgagtg acacaacaat 3081841 ggctagaacc gcgataccaa tactttttct cgtatatggc gatgcttctg cacctgaaat 3081901 gtcttttgtt tcatattgtt tcggtttacg gtatacgatc actgataaaa taaggccgac 3081961 aaccatacct gcaactggaa taatcagtgc gtacggaata tcagcaagcg gaacgtttaa 3082021 cccggcatcc gccatattgt ccttcagcat gccttggaag atttggccga aaccgaccgg 3082081 aagcaaaata taaggagccg ttaagccaaa tgtaattaca cacgcgatca gacggcggtc 3082141 catttcaagt tcattaaaga ttttcaaaag cggcggaatc agcaccggga taaacgcgat 3082201 gtgaaccgga acgacgtttt gcgaaaaaca agatacaatt aaaataatca gcacaatcag 3082261 caccttagac agtgcttttt ttcgagaatc ttctttattt ccgattaatt taacggaggc 3082321 ttccaccatt gcgtccggaa gacccgtttt cgtcaaagcg gcggcaaacg cgccaagcat 3082381 ggcatagcta actgcaacgg tggcatttcc gccgagaccg tctgtgaaag ctttaaccgt 3082441 ttcgccaaga ccgagcccgc ctgttaaccc gccggccaag gcgcctataa ttaatgcgat 3082501 aacaatattg acacgcagca ggcttaatac aagcataagc aggactgcga tgacgactgc 3082561 attcatgatg atacccctcc aaaaatcctt tagtttgcta atgtagtaga taaataaagt 3082621 acgaacgtat cgtatcataa ccgatccact ttagtcaact aaagatttcg gaagaaaaaa 3082681 tccctgccgc atcatacagc agggattttt cattactcgt ttttatcttc ttccaatgta 3082741 aatcgctccg caagtgtagc cagtgttctt gccataacgc cagtagcccc ggccggtccg 3082801 aagcaggttg ctttattggc agtcgctgtg cctgcaatat caaggtgaac ccaaggtgtt 3082861 gactcagcga attcaccaag aaacgttcct gccataatcg catgtccctc gcgtcccggt 3082921 gaattgctga gatccgccat ttggctgctt ttcacgcgtt ttttatcctt ctctgttatc 3082981 ggcagctgcc agatcgcctc gccgcactct tgtgcagcat cagctacctg ctggtaaaag 3083041 ctttgatcat ttgtcattgc accggttgtt tctgttccta atgccacaac gacgccgccg 3083101 gtaagcgtag ctacatcgac aagaactgat gcgccatgct gtttcgcgta tgtaatgcca 3083161 tctgcaagca ctagccttcc ttcagcatcc gtattaagga tttctattgt ttttccgctt 3083221 aaagatacga tcacgtcatc cggcttcatg gccccgccgg agatcatatt atcggttgat 3083281 ggaataacgc acagcacgtt ttgttcagga cgaagctctc cgatcgtttc catagccccg 3083341 agaaccgcag ctgctcctcc catatctgat ttcatgccaa caattccaga tttcgtttta 3083401 atggagtagc cgcctgtgtc aaaggtaatt cctttcccga ctagtccgac gacgtcttcc 3083461 cattcctttt tgccctgata tttcaacaca atcattttcg gcggttcggt ggagccttgg 3083521 tttaccgcaa gtattccgcc cataccgagc tcttccatct ctgatttctc caatatctca 3083581 cactcaaaat catatttcgc cgcaagctct tcagcatacg aagcgaggtc agtcgctgtc 3083641 agcatgtttc ccggcatatt cacaagcgtt ctagccgaat ttgtcccttg tccgtatgcc 3083701 tggccgacgc gaagccctgc ctgcacttcc tgtgtatctt catctgttac aacatacacg 3083761 gcttcaattt gtttgtcagg ctcatttgat ttatgcttat aatcctgcac ctcataggaa 3083821 gcaagcaggc agctctcagc taaagcatga gcggcatcgg ctggaggcac gtcttccgaa 3083881 ataaacgtat caagcagaac agcagtttct tgttttcgat ctttatgaat ggcttgaaaa 3083941 acatgagcaa aacgttcctt cgcctgttca aacgaataat ttgcttctct ccccaggcca 3084001 acgaaataaa tccgtttcat acccgcagaa gatggaggga atacttttga tacttgattc 3084061 ggtttcgcag agacatcacc ctcttttaaa agctgtgtca gatggccttc gagcatttca 3084121 tcaatttcca acgcttttcc tgtcagctgg cttttttgaa aaagcccgac aacaagggtt 3084181 tctgtatgct ctgattgttg aaccgcataa aacatgaggc ttacactcct aacgtaatgg 3084241 gtatttgtaa tgaacaatgg tataatagga aaaacattct ttccactata cttattttaa 3084301 caaacaacag tctaagactt gcttttttct tttgaaacac gaaggatttt tcaaatagaa 3084361 aggatgtcgc cgatggaact tttaacgaat tttcctttat tatcaagcct ggccgcaatt 3084421 atttttgctc aggtcatcaa agtgcccata cagtttatcg tgtccagaaa actggactgg 3084481 tcgctggtca caagcacagg cggcatgcct agctctcact ccgcagcggt cactgcgctt 3084541 tctacaggcg tagccttgga gcatggatta gactcctcac tctttgcggt ttccgccatt 3084601 ttcgccgtca taaccatgtt tgacgcaact ggcgtcagac gtcacgccgg tgagcaggca 3084661 acagtcatta ataagcttgt tattgatttt aaccgtttcg taaatgaagc gaaggacttc 3084721 cctaaggctg cagagaaaga aaagcaaaaa aagctgaaag agcttctcgg acatcagccg 3084781 atcgaagtct ttttcggagg attaacaggt attttactga cattggtact cgcttacttt 3084841 ttcatgtaaa aaaaacgctc ctgctttcgc tggagcgttt tattctttca ccgttttata 3084901 ttgatttctg aacacttgca aagattttgt ttcattgagc ttctcaagct catcctcggt 3084961 aatctttccc gttccctttt taatcacata tacatcaagg gtttttttgc cccattcatt 3085021 gtatacatct ttgactgtct caaagtacag atcaaggcgg tttcccttaa tagctgatcc 3085081 tgtgtcggcc acaactccga gaccgtagtt cggaatgaat aaaattgttc cgatcgggaa 3085141 aacggacggg tcagcagcaa ccgtggaata taaatcccgt ttcactttca cacctgaata 3085201 tgtaagcccg tataatggat caccgggatt tttgcccgtc gactcagctc ctgctgtgta 3085261 gcctgttgct gttactcttt ggactggata ttcatcccaa tcaaatgcct cttctaacgg 3085321 ttttgtttta tcctcagccg cggacgtggt ttgtgtttgt ttctgctgca atgcttttaa 3085381 tctcagtcct gcatgcttca agtgcttttc ctgatgttcc tgcacccatt ttgacaagtc 3085441 cttcgcttca attcctgaca ctgataaaaa tgtcgtgcca aatgcaagca gaaataaaca 3085501 ggtcatcagc aaacgtctga tcatattcaa catcattcac ctctcctccg aatcattgtt 3085561 cccaagtgga gagagcatta ttcaaaatgg tgaatgagct gaacgcataa aaaaagcttt 3085621 ctttagaaga aagcggcatt taaaacattt gatatcctct ttttctaagc atgttgatcg 3085681 ctataccgga cacgatggcg ccggccaaac cgctgactaa aatcagcaca tcagcagccg 3085741 ctaatgataa gacacgatga aacaggctgg caaaggattc tcccggcgac tggacatagc 3085801 tgatcagctt ttctttgctg ataatgaaaa ggcatacaat tggataaatc acagccataa 3085861 tccaagacat tctcagcagc atgtttaata agaaaccgat tccaaaaaac aagacaaaaa 3085921 acaaaacaat tgagatgatt acgactggca gactaatcaa cctattccac ccccctgcgt 3085981 tgtttttagt gtaacgcggg ggctgaaata aagtcaacgg ctggaaaaag aatgactgtc 3086041 ttttcctgtc ccctggcaag acggacaagt ctctgaaccg ccgagaatca attgaaaata 3086101 tcctttccct gaacaaaatg ggcatgcatg tgaagcggtt gtcgttgcag ttttcatcta 3086161 atcatcaccc tttttcttaa ttttctgata atataccata tcaagctgtc aacaataaag 3086221 tcagatcatg tgacaaatct tttgatgtaa gcggaaacat acttgttttc ctctcgttct 3086281 ctttttattt tggcgttttt taataaagaa aacccgcttc cgcgggtttt tagaaaaact 3086341 tgaacttgcc ttttttcaat gtcagtccga gtccgccaat cataaacagt gagcggttat 3086401 caatgacttt tttcataaac gaagcgggcg tgcctttcag ctttctgcca taaacaaccc 3086461 caaccgcgtt atgctcgcca agagaagcca ctgttccctt aatgtccggc ttgaattcct 3086521 caagctctcc gcctttaata agcctgccaa ggtttttagc gaccgttatg ccctgctgca 3086581 ttgcaatttg cgcagtcggc ggatacgggc gctctgtatc ttcattcata aacagcgagc 3086641 tgtcgccgag aataaagaca ttgtcatgtc ccggggcgcg gagatcaggg ttgactttga 3086701 ctcggccgcg catattctca aaaccggctt cctccacaat cggatggccg cggacacctg 3086761 ccgcccatac aacggtttgc gatttgatct gctctggttc ttcatctttt ttgccgactc 3086821 tgactccttc tggtgtacat tcttgtacag ccgttccgat cttgaactca actccgtttt 3086881 cctcaagata atgtacggcg taatcaacaa gttccggatc aaagcccggc aaaacggtcg 3086941 gcgctgcttc cacacaaatg atgcggacaa ggcttctgtc aacgtcatat tccttacaga 3087001 gctccggcac gcgagcagcc agttcgccaa gaaattcaat tcccgtaaat ccggcaccgc 3087061 caacaacgat cgttaacctg tccggccgtt tttccgcttc cgtattgtaa gtcgcaaact 3087121 gcagctcaat atgttcccgc agcaggcgcg acgtgttgat gttggcaatc ggaaacgcat 3087181 attcttttaa gcctttaatg ccgaacgttt caggcacggc gccgagcccg atgactaaat 3087241 aatcgtactg caattctcca ttcgcaagca caactttttt ctcatcaatt ttgattgcct 3087301 ttacggtatc ctgtacaaaa ttcacccgtg actggttgat tacatctttt atctgataac 3087361 ggcagcggtc atgatggagc gtacccgcgc tcgcttcatg catccatgtc gtttcataat 3087421 gataattgtg tttatttaca agcgtaatgt cagcatcatt cggcccgaca tacttcgtca 3087481 gccttgtcac cgtcatcaat ccgccatatc ctgcacctaa aatcacgatt ttgggcttat 3087541 tcaatgccat cacatccacc ttctcttttt ttgcttttgt tagacccata ataaaatcat 3087601 catttgtgtt agcttcagct tattggcggg attttatgaa atatattgaa aagttttttg 3087661 tgaagtcctt acccgtagca ctattatcat gtttatccgg ctggcccaag aaacattcag 3087721 aaaaagatca tttcatttgg ttattatcgt agcggcctgc ggaaatattt tcaagaacgg 3087781 atgggcacgt tagatcctta cgattttttc tgctgactcg tcaatttgaa cggcaatatg 3087841 gtataattaa taacaatttt catttaggag gcaattttcg tatgcgagag gatacaaagg 3087901 tttatgatat tacaattata ggcgggggac cggtcggctt attcaccgct ttttacggcg 3087961 ggatgagaca ggcaagcgtc aaaattatcg aaagcctgcc tcagctcggc ggacagctta 3088021 gcgccctata ccctgagaag tatatatatg atgtagcggg attcccgaaa atccgcgcgc 3088081 aagagcttat caataaccta aaagagcaaa tggcgaaatt cgaccaaacc atttgtctgg 3088141 agcaagcggt tgaatctgtt gagaaacaag cggacggcgt gtttaagctt gtaacaaatg 3088201 aagaaaccca ctactctaaa acggtcatca taactgcagg aaacggcgca ttcaaaccga 3088261 gaaagctgga acttgaaaat gccgagcagt atgaaggcaa aaacctccat tacttcgttg 3088321 atgatctgca aaaattcgcc ggcagacgcg ttgcgatcct tggcggtgga gattccgcgg 3088381 ttgactgggc gcttatgctt gagccaatcg caaaagaagt atcgatcatt caccgccgcg 3088441 acaagttccg agcgcacgag cacagtgtgg aaaaccttca tgcgtcgaag gttaatgtcc 3088501 tgacaccatt cgtccctgcg gagctgatcg gcgaagacaa aatcgaacag ctagtgcttg 3088561 aagaagtgaa aggcgaccgc aaagagattt tagaaattga tgacttaatc gtcaactacg 3088621 gtttcgtttc atctcttgga ccgatcaaaa actggggcct ggacatcgag aaaaattcca 3088681 ttgtcgtgaa atcaacaatg gaaacaaata tcgaaggctt ctttgcagca ggtgacattt 3088741 gtacatacga aggaaaagtc aacctgattg ccagcggctt cggcgaggca ccgacagcag 3088801 tgaacaacgc caaggcttac atggacccga aagcccgcgt acagcctctt cactcaacaa 3088861 gtctttttga aaataaataa taaaaaaagg agcttgtgtc tgcgacacag ctcctttttt 3088921 atttgaagat atttatataa ttcaatgcag ttcctacaac cagcgcaatc acaagggctg 3088981 cgactaccca gatcattgcc ataataatgc ggtcctgaat cttttgggac ttcggtgttt 3089041 tttcttcgtt ttgggccatc ttattcgctc ctttcccatg tccatgccat aaagaaagcc 3089101 tggtgctgaa cgaccaagct ttgctgaacg tatatcattc gcgttttgat ccgctctcta 3089161 agaccattcg ttaaaactat gatacctaaa ctcaccctgc atgacaagct tcggcacttg 3089221 caccacacct gccagcaaat cataatgttt gacatcctaa ataaaacaga gtacattata 3089281 taaggcgaac atttcatata ttatactttt aaatattcgt ttttaggagt gaaaaccatg 3089341 gaaaacgtat ttgattacga agatattcag ctaattcctg caaaatgcat tgtgaatagc 3089401 cgttcagaat gtgatacatc cgtacgttta ggcggacata catttaaatt gcccgtcgtc 3089461 cctgccaata tgcagacgat tatagatgaa aaactagcga tttcattagc cgaaaatggc 3089521 tacttttatg tgatgcaccg atttgagcct gagacacgaa ttgattttat taaagatatg 3089581 aacgcacgcg ggttattctc ttctatcagc gtgggcgtca aagatgagga gtatgaattt 3089641 gtccgccagc tggcagaaga aaatctgact cctgaatacg tgacaattga cattgctcac 3089701 gggcactcaa atgctgtcat tgaaatgatc cagcacctta aaaaacattt gccggacagc 3089761 tttgttattg ctggcaatgt cggaacgccg gaagcggtca gagagcttga aaatgcggga 3089821 gcggatgcca ctaaagtcgg catcggaccg ggaaaagtat gtattacgaa aatcaaaaca 3089881 ggcttcggca caggcggctg gcaattagca gcgctgcgct ggtgtgccaa ggctgccagc 3089941 aaaccgatta tcgcggatgg cggcatccgc acccatggcg acatcgcaaa atcaatccga 3090001 ttcggcgcaa cgatggtcat gatcggttca ctatttgccg gacacgaaga atcgccaggc 3090061 caaacgatcg aaaaagacgg aaagctttac aaggagtact tcggctcagc ctctgaattc 3090121 caaaaaggcg aaaagaaaaa tgtcgaaggc aaaaaaatgc acgtggcgca taaaggctca 3090181 atcaaggata cactgattga aatggagcag gatcttcaat cttctatttc ttatgcaggc 3090241 ggaacaaagc ttaacgccat ccgcaatgtg gattatgtga ttgtgaagaa ttccattttt 3090301 aatggggata aatattaatc ataaaaaaac gccaagtcag cggttctccg cttgagttgg 3090361 cgttttctgc tacttcttca gcaaagtaag cttatatttg ctttttgagt ttatcttcca 3090421 tcagttctgc catttgtttt gcatttggat tttcttcatt ttgcaactgt tcaatgacgt 3090481 tcatataatc cgtttcattt cggttctggc ttaatttata tgccgcttga atgtcttcca 3090541 ccttaatctt aaatccaaca atacctttca attcactttc taagagtttt ggagaaagct 3090601 tatcccataa cacaggattg tcacgatgtt tttcgtattt ctccaacatg attgttaatt 3090661 cttctgctaa ttcatctttc tctaacatac ttgcttttcc atacatgtgg acagcctgat 3090721 aattccacgt cggaacattt tcgcgcgaat accaggaaga agaaatataa gcgtgcggtc 3090781 cctgaaacat cacaagcaca tcttcacagg cttcaaacgt tctccactga ggatttccat 3090841 aagcgaaatg ccccgtaata tagtaatgat cgtctttttt attgaatcct aacggcaaat 3090901 gtgtggcaat tggttttcct tgttctgttg tgacaaccgt accaaaggag ttttcttgta 3090961 caaaattcca aatttcttca gcatttgtga ctttaaaata ttttggaata tacatcatca 3091021 tccacccttc gaaaaatatt atatgagtgt tttagccatg attaaatccg tttgttcttc 3091081 atcacccata taaaatgagt gggcgccggt ctgaacaaac cccattttct tataaaaggc 3091141 aatggcattt tcattttttt cccacacacc tagccaaatg ttctttttat tacgttccag 3091201 cgcaatttct atcgctttat tcagcagatg tttgccaagc ccatgttttt gaaagctgtt 3091261 ctttatataa attctctcga tttcaagtga ttcagcaccc atttcttcag actgagcatc 3091321 atcgatattg acctttacat atccagcgat ttcatgatca aagtaaataa aaaagaattg 3091381 cgaagacata ttagataact ctttttccag ctgctcagtg ttaaatgcgc tttctaaata 3091441 ggctttcata ttttcaggtg agttctgttc tttaaaagtg tcattgaatg tttcaatact 3091501 caattgttga agtgtttgta aatcttcccg gctgcatttt ttcattttta cactcattgt 3091561 tcggattcag cccctttatt taaaattcaa ttgtcttgtg tcccttttat atatttaaac 3091621 acggaacaca tactgacctt gttaccattc caaaaatctt cttcatcacc aactccctat 3091681 cgtgattttg ttgtaaatgc aataaaatat actccgcatt aaatatatcg taactttgct 3091741 gtatttacaa caaaaatcaa acaacaaagc agcgtttctc ttgccgaagt tcccggaact 3091801 ctctgcatca tttccccata ataaaaacgc ctcccttaac gatgatttat cgctaagaaa 3091861 agcgtcagta atagttgcta tccgttttta gtgcttagca ctcttcaggc ttgcctgcat 3091921 tcgttgctgt tctgaacgaa gaaccgcagc cgcatgaagc gatggcgttt ggattgtcga 3091981 tggtgaagcc gccgccgagc atggattgtt tataatcaat cacggtgccg ttcatgatgt 3092041 caaggctttc tttgtcaact agaacagtga tgccgtgctg atcaaacaca ctgtctgatt 3092101 cactcttttc atgctcaaag cccatgccgt aagaaagtcc gctgcagccg ccgcctttga 3092161 cgcctacacg cagaaacgcg ttttcttctt catgctcttt catcatatct tttatatgca 3092221 aagctgctgc ttctgtaatt gttaccgggt tgctcatcat tatgaacctc cttttaaaaa 3092281 ccggttgctg tcttttatta taaacatgat cgttccaatt ctcaaacaag gtgttttaca 3092341 agaaatagac accctcacaa acggtttcag ccggccctgt catcattaca tggccgttat 3092401 ctttccagtt tatcaccaaa tccccgcctg ctaaatgcac cgtgatgtct tgatttcgct 3092461 ttgatacgcc gtttaataca gatgcgactg ccgctgcaca tgctcctgtc ccgcatgcct 3092521 gagtaatccc tgatccccgt tcccagacgc ggaaatgcaa ttcttgttca ttcacggttt 3092581 caacgaattc cacattgatg ccttccggaa atctcggatc tttctcaatc accggcccca 3092641 gtgtcgttaa gggtgcctgt tcaatgtctg cgatcggaaa aacgatatgc ggatttccca 3092701 ttgaaacggc agtgcctgtt agttctactt caccaaatgc catcgtttca ttgattgtgt 3092761 gctcttcccc gccgtcaagc ataggaagct cggattttgt caagcgcggt tcgcccatat 3092821 cgacagtgac cacattcact tttccgtttt cgacttgaac ctccgctttc acaagcccgg 3092881 agagagtttc aatcagaaaa gatgtttcct caaccagctt atgctcatat gcgtattttg 3092941 cgacgcagcg caggccgttg ccgcagtttt tcccttcaga cccgtcatta ttaaaaatcc 3093001 gcattttaac aggcgcttgg tctgatgggc atatcaggat cattccgtcg gatccgatcc 3093061 ctgtataaac agaagaaacc tgaattgcaa tctctgacag tttttcttct ggaagctgtt 3093121 cttcaaattg attcacataa atataactgt ttcccaggcc gtgcattttg gtaaatcgaa 3093181 atgagttcat aggtgcctcc aacttttttt ctttttctta gtataaaagc tattataagc 3093241 ggacacaata caattatccc ccgtttttca tacataaaag ctccttgcac tgacgcaagg 3093301 agcttttatc gtttatataa acatgccggc aatggctgcg ctgagcagat tggctaatgt 3093361 tcctgcaaga acagccttca ggccgagacg tgcgatatct gaacggcggc tgggcgctaa 3093421 accgccaagc gtaccaagca taatcgcaat tgatgaaaaa ttggcgaatc cgcataacgc 3093481 gaaactgata atggtagcag ttttcttaga aaactcgccg atgtgcgaac cgaagttaga 3093541 ataagcgaca aactcattca gcaccaattt ctggccgata tagcttcccg cctgcaatgc 3093601 ttcatgccaa ggcacgccaa tcaaaaaggc gataggagaa aacacatagc cgagaatgga 3093661 ttctaatgtt acgcctttta aaccgaacaa gccgaaagcc ccgccgagaa taccgtttac 3093721 tacagcgatt aacgcaacaa acgcaagcag catcgcccca acatttaacg caatttgcag 3093781 tcctgttgac gctccctttg cagctgcgtc aatgacattg gctgcgcctt cgccttcatc 3093841 cattttgaaa tcgcttttta cggtttgcgt tttttccgtt tcgggtataa tcaatttacc 3093901 aaagactagt ccagctggag cagccataaa gctggccgcc agcaagtact caatcggaat 3093961 accgagaagc gcgtacccaa acaaggtaga tcccgcaact gccgatagac cgctcgtcat 3094021 aatcgtaaac aactcagagc gcgtcagccc ggcaatcagg ggtttgatca ctaacggaga 3094081 ttctgattgt cctacaaaaa tattggcagc agccgccaga gattccgttt tgcttgttcc 3094141 aaggagcttc gacaatccgc cgccaatgac acggaaaacg agctgcatga ttttcaaatg 3094201 atataaaact gcaatcagtg ctgagaagaa aatgataacg ggcagtacac ttaatgcaaa 3094261 tgccggactg tctccgacct ttagaagcgg tccaaaaata aaactgatgc cttcattcgc 3094321 atagtcaatc agaagctgta cacggcttga aaaccataaa aaaacagcgc gtcccgcttc 3094381 ccatttcaac acgatgtatc caaacgccac ctgtgtgcat aaaccaacga tgacggttct 3094441 tatcttaata ttgcttttct tttctgaaaa taaaaacgcg atagcaatga tcgcaactgc 3094501 gcccagcagc ccccacagaa cattcatgaa tactcgtaca cctcttaaat tttatttaaa 3094561 aaaatatctt ttatacgata acaataatat tttttgatgt ctacacattt ttttagttct 3094621 tttgtacggc aaaataaaaa agggcctgtc caggcccttt tctttaaaac attggatttt 3094681 cttcaataaa ggtatatata ttctcaacaa gctcagcagg cgtttcaccc atgacgactt 3094741 ctccgtttac cagagcgaaa agcgattcca tacatgtccc gcagtagctt aagcagccat 3094801 attcaaggac atcaaggttg ggatccttct ccaaaatcgc ccgggcttcc tgagagccgt 3094861 gagccagatt gctgacacaa aattcaatca ttggattcat gcggtttcac ctcacatatg 3094921 tccattatcg cgaatttttc actattcgtc aaagacaacg gatgattcaa aatttattat 3094981 cgtaacatat tatttctcaa ataacgtttt actaatttgt gttttcaggc taaattgtag 3095041 gttattttga aactattatt gtgattttag atcaaattcg atataattct agatgttatt 3095101 ttacatagtt cgtattttct tcaatgtatc tatcatactc ttcggattaa aggggaattc 3095161 aaatgaaaaa attggtcttg atcggcggag gttacgggaa catgcgcgtt cttcatcgct 3095221 tattgccaaa ccagctgcct gatgatgttt caatcacgtt aattgacaga aatccttatc 3095281 actgcttgaa aacagaatat tatgcccttg ccgcaggcac aatttctgac catcatatca 3095341 gagtgtcatt cccagagcac cctcgcctgg atgtccaata cggtgatatc acatcaattg 3095401 atattgtaca aaaacaagtg ctgttccaag atcgtgaacc gatttcttac gatgacgcca 3095461 taatcgggct cggctgtgag gataaatatc acaacgtgcc gggagcgcct gaattcacct 3095521 acagtattca aaccatcgat cagtcccgcg aaacctacca aaagctgaat aatctgagcg 3095581 ctaatgccac cgtcgccatt gtcggagcgg gcttaagcgg cgttgagctt gcaagtgaat 3095641 tgagagaaag ccgtgatgac ctgaacatta ttttgttcga ccgcggtaat ctcattttat 3095701 caagctttcc cgagcgttta agcaaatatg tgcaaaaatg gttcgaagag cacggtgtcc 3095761 gcattattaa cagggcaaat atcacaaaag tagaagaagg cgttgtgtat aaccacgatg 3095821 atccgatttc tgcagacgcc atcgtgtgga cagccggcat ccagccaaac aaagtcgtca 3095881 gagacttaga tgtggagaag gacgcacaag ggcgtattgt attaacgcct catcataatc 3095941 ttccaggtga tgaacatctg tacgttgtcg gcgattgcgc cagtcttcct catgcaccga 3096001 gcgcccagct ggcagaggct caagcagagc agattgtcca aatcttgcaa aaacgctgga 3096061 atggagaagc cctgcctgaa tcaatgccgc agtttaagct gaaaggcgtc ctcggttcac 3096121 tcggaaaaaa agccggcttc gggcttgttg ctgaccgtcc gctgatcggc cgtgttccgc 3096181 gtatgctgaa atccggcttg ctgtggatgt ataaacacca taacggttaa tgatagagaa 3096241 gaaccgctga tcaagtcagc ggttttctgt atacccatgc ttctccattt cctcataaac 3096301 gtcttttaat tttggattgc cttcaccgac aattttgtct tctacaagca caagcggata 3096361 aaaatactcg tcatttctga ttttttccgc aagctctttc gcatgttcat tgtcaggcgg 3096421 ctcatgaata tcgatgtact gcatctcaaa aggctgattt ggatattttc ttttcagcgc 3096481 agcctcaagc cactcgtatg tatccttggc tgtcggcata tttacacagc tcgcacaaac 3096541 gttttctgcc ccgtacacgc ttagcatgac tggtttcatc acttgtagac gcccccttct 3096601 cctatgtaag tcctttcttt taagtataca gagcctaagg gcgtttttat agaaaaaaac 3096661 cgtttttgtg ttgaagtctg aatgtgctat aatagggaaa gcaactttgc aaaccaaaca 3096721 atagattttt attgttacac tgaatataat ggttttatga cgacgaaagg agcgaatgtc 3096781 atgactgaag ttgaaatgaa agaacaggtg caggaagtac tggacaaact tcgtccgttt 3096841 ttacttcgtg acggcggtga ctgtgagctt gtagacgtag atgaaggtat cgttaagctt 3096901 cgtcttctag gcgcatgcgg cagctgccca agttcaacaa ttacgttgaa agccggaatt 3096961 gagcgcgctc ttcttgaaga agtgccgggt gtcgttgaag tagaacaagt cttttaataa 3097021 agcagccagg ctgatatttg atcagcctgg cttttttatt agagatgttg atcaaaccat 3097081 gagctgatat aattcaggcg cttgatccgc tgtcttgggt gtccggtgcg tgataaattg 3097141 tgcgatgcat tcggaaaacg gacaagcttg gtttccttgc ccattttttt cagagcgata 3097201 aacagctgct ccgcctgctc gatcgggcat cggtcatccc gctcgccatg cagtatcaaa 3097261 agcggtgtct ccacgtttgc tgcgtatttt aaaggagacc ggtcccagag cttttctgtg 3097321 tcctcaaaca tgtcatgctc aagctgccag tctgtaaaga aatagccgat atcactgacg 3097381 ccgtgaaagc tgatccaatt tgatatcgag cgctgggtaa cggcagcttt aaagcggttc 3097441 gtctgcccga cgatccagtt ggtcataaaa cctccgtagc ttccgcccgt gacaccgagc 3097501 cgcttaggat caatatgcgg atctcgtttg atagcctcat ccacagcctg catcacatcg 3097561 tcataatcct ttcccccata atctcctctg accgcattca caaattcctg cccgtagccg 3097621 tggcttcctc tcggattgat ataaacgacc gcgtatcctt tcgccgccag cacctgaaac 3097681 tcatgaaaat atgtatgtcc gtacatcata tgcggaccgc cgtgtatgtt aagaataagt 3097741 ggatatgttg tctcaccttc catttgtgca ggcctcatca gccagccgtt caccatcacg 3097801 ccgtcttctg tagcatattg aatctcttca ggtattgata tcgtatgctc cctgacaaac 3097861 ttgtcattcg cgccagtcag ctgtttctct tcctgtccaa gcgggatact gtaaagctca 3097921 ctcggtctgt ccggctttgt cacactggca ataaagtgct gttcatcagg tgaaagagaa 3097981 aagctattga tgtactcttt ttccagacga atcggataca caaggccttc aatcgaaata 3098041 taatagatgc ccgtactgcc ttgatctgtg ccgatgacat aaaacccttg gctgtccttt 3098101 gtccaaatcg ggcgctgttc agcaccaccg atcaatgaat ctccaatcag cgcatccgct 3098161 aaatgaacgt ccagcatctc agtaagacat gtgaggcggc cttgttcgat atcatagagc 3098221 cacgcctttg agagcgtagc attcttatat tccttttcat ttccaagcaa agcaagatac 3098281 cttccgtctg gtgaaaatga gcttgatccg aatgagccgc gatgaggtgt aacctgctta 3098341 agatctccag actccagtga cattatgtaa acatcatgcg gcttgctggc atcatctgtt 3098401 tcagttaaat tagctgagaa aacaagccat ttgccgtcag gagaaaaagc aggatcacca 3098461 tgatcagctt tgtgacttgt cagctctttc atctcacccg actttacgct gacaagcaca 3098521 agctgggcat acgcacctct cgtcagccct ttgccgtccc gtttgtagga gaggccttgc 3098581 acttcaacag gttcatagct gtcctgctct gttttttctc ggtcatcaat gctttccccc 3098641 tctcccaaac tgacagtgac cagaatcgat tcaccgtccg gggaccatag cggctttgac 3098701 acgccatatg ggatatcagt cagttttctt gcttctccgc cttcagtgct catgatataa 3098761 agctgtgccg catcgccttc tcgatcagaa ataaaggcaa gcgtgcgccc gtccggagac 3098821 catcttgggt cggtgcttcg cttttctcca tgtgtccaag gaacagatcc tcccgttttc 3098881 gtttcataga tccatatatt tgatgtatac gaatctttct cttgatttac ttgtgatttt 3098941 acatatgcgg cacgggtacc gtctggggcg tattgaggat cggtcacaga gacaatcgct 3099001 gtgatgtcgt ctgcggttat cagctttttc atattcatct cctccttttt acatgtattt 3099061 cgtttttcta aataaaaact cctttatctc cagcaaaaaa aagcgccctc cgctgacgct 3099121 gaggaacgct tggcatgatc tatacacttt ttacttgata taaaggattt cgctctatta 3099181 tacttccctc tttcggaacg gtcaaagcgt ctacttcaca atgagggaaa tgaagcgcga 3099241 gctgttcttt tagctcttct ccctttcctt tttcggtcat gacgagaatc gttgggcctg 3099301 ctccgctgag agccgttcca tatgcgccct tcatctcggc gacgtgctct acttttgaca 3099361 gctcaggcac aagcatcgcc cggtacggct gatggaacat atccttcttc atgattttcc 3099421 cgacaagcgg ccaatccttg gacatgatcg cagcaatgag gatattgctg acagcacttg 3099481 cttttacggc atcggcatat ggaaactcct tcggaagcac gtctctcgcg tctcttgtca 3099541 gcacttcata aaaaggaatg acaacgacta cgtcaatgtc agcattcggg acgcggatca 3099601 tttgggtctc gtcatcctca tgcaggccga tcacaagtcc gccgacgaga gaagcgccag 3099661 cattgtccgg gtgtccttct tctagactcg ctaaatgcag cttgtccgct tcagacagct 3099721 ttaagccgca taattcatca gccagttcaa tggccgctac aatcgctgcg gcgctgctgc 3099781 caaggccgcg tgcaagcggg atgtcgctcc acaccttcac atggacagga ggcatttctt 3099841 ttccgtacaa atctgcggtc cgtttagcca cttggtagat caggttatct gtacccgccg 3099901 gaattccggc gactgtttct gtttcagcct caaaagacca tttgtcgctt tcaaagacgg 3099961 tcagcttcaa atatctgctg agcgccattc cgactgaatc aaagccgggg cctaggttag 3100021 ctgtgcttcc gggaacagtg acagagaaca gcatgtcggc ttcgttcata cacgggccgc 3100081 tccttttaca tattcaagga tgctgtcttc atcagtcggc aatgtgacag gcttgatttc 3100141 tgaaatgtcg accgctgtgt tcggatcttt cagtccgttt cctgttaaca cagctacgac 3100201 cttgctgcct ttcggaattt ctccggattt cacctgtttc agcactcctg cgatagacgc 3100261 gcaagaacct ggttctgcaa acacgccttc tacacgggcg atcagctgat atgcgtgaag 3100321 gatttcatca tcagtgactt cgtcaatttt cccattggat tcctcggctg cctttacagc 3100381 tttgtcccag cttgccgggt ttccgatacg aatggctgtc gctattgttt ccggattttc 3100441 aatcacttca ttgcgcacga ttgccgccgc accctcagct tcaaagccgc gcattttcgg 3100501 aaggcctgtg ccgtttttct catgatattc cttgaagccc ttccagtacg cagtgatgtt 3100561 tccagcattt ccgaccggga tcgctaaaac atcaggcgct tcccccagct gttcgcacac 3100621 ttcgaaggca gcagtttttt ggccttcaat gcggtaaggg ttgactgagt tgacaagggc 3100681 aatcggtgat ttctcacaga tggaacggac aattttaagc gcatcgtcaa agtttccgtc 3100741 aattgcgata atctcggctc cgtacatgac agcttgagcg agttttccaa atgcaatttt 3100801 tccgttcggg atgatgacaa tgcatttcat gttagcacgg gctgcatatg ctgccgcagc 3100861 agcggaagtg ttacctgttg acgcgcacat aatcgtgtca ttgccttctt cttttgcctt 3100921 tgccacagcc ataaccattc cgcgatcttt aaatgatccc gtaggattga cgccttccgt 3100981 tttgacatga agctcaattc cgagctgctc agacagcttc ggcaggtgaa taagaggtgt 3101041 gtttccttca tgtaaagtta gcgccggtgt ttgatctgtt acaggtaaaa attctttata 3101101 ttgatggata agtcctttcc acattagctc caaccgttcc cttctacacg atatgtgctt 3101161 ttgacttctt gaacgacttc caaatcattt aggttttgca ggatatcact gaaatcagct 3101221 tctgatgtat gatgtgtgac aattacgatt tcagctaact catcatggcc tttaattggc 3101281 agctgaagga ttttttcaaa gctcacgccc cgctctgaga acacagatgt aattttcgag 3101341 aatgaaccaa cctcatcttt tacatgaatt cttaaaaact gctgtgcata aatgtcagac 3101401 ggcgatttca tgtttttctc atattgcggt ccgacaaagc tgttgccggt tacacctagg 3101461 cgcatatttt tcatgacagc gacgaggtca gaaacaacgg atgtcgctgt cggcatgctt 3101521 ccggctcccg gcccgtagaa catcgtctca ccgacagcct cgccgtatac ataaacagcg 3101581 ttaaactcat tatgaacagc agaaagcgga tgatggtcag gaagcagtgt cggctgtacg 3101641 ctgacctcga ttttgctgcc gtcacgctga gcaatcccga tcagcttcat tgtatagccg 3101701 aggcgtttgc tgaagctgat gtcctcgtct gtaatttggg agatcccctt tactttgacg 3101761 tcttccagat ccacgttcat cgagaagccg aggcgcgcca atatcgccat tttccgtgcg 3101821 gcgtcaagcc cttccacgtc agaagtcgga tcagcttcgg caaaaccgag atcctgcgct 3101881 tccttgagca cttcctcgta tgggcttttc tctttgatca ttttggttaa gataaagttt 3101941 gttgtgccgt tcacaattcc catcattttt gtaattcgat ctgatgagag gccttcctct 3102001 aacgtgcgca gaatcggaat cccgccggca acactggctt caaagtagat atcgcatcca 3102061 ttttccttcg cttcggcaag cagctcggag ccgtacacag ccattaagtc cttgtttgct 3102121 gtgacaacat gctttttcga tctcagcgcg tcgaccaaat attgttttgt ctgttcaacg 3102181 ccgccgatca cctcgatgac gacatcaaca tctggatcat caatgacatc atacacttct 3102241 gtcgtgagca cttccttcgg caaatctact tctctctttt tctctaaatc ttttacaagc 3102301 acttttttta tcgtaaccgg acagccgacc tgatgcataa gcttatcctg atggtcttga 3102361 ataattttaa cgacaccgct tccgacggta cctaaaccta aaagccctac acgaatcgct 3102421 ttcaaaaaaa ctccaccttt cttttgattg tcctcttgga aaagacaatt gttaactcaa 3102481 cacagacata taagttacaa acattatata agcccgctcc tgttttgaca agacatcatt 3102541 aggctgaatt ttgcgaatgt aaacgcttaa cgcattgata tgacaagatt ctttattttc 3102601 taattatttt tgtcagattt tctcctcacc ttgagctgcc tttgccgagc cagctgacgc 3102661 gtggaacaaa cagcttctgc gcccgcatat tcatgaattc ctgcgctgta ttgagaaatt 3102721 gttcataacg cccacagtca ttaagaatga agtcaagctg ttcttcaaaa taatgctttt 3102781 ctgattctga tgacatgtaa tagctttcta cgatttcaaa ataatgaagc gggaaaagca 3102841 gacggctgta taaaaggcgt ttcgaaaatg aagacagcgg tgtgacttgc tcgtattcct 3102901 gtaaaaagag aaagccctgc tgattaaaat cttgtctgtg atgcaaaaac gtatgcctca 3102961 tatattcagc caaatcacgg gaagcgtggt caaacaccca atccgccgga atcctgatca 3103021 atgattccgg tgaccatgta tgcctttcca tccgctgatg gcatatcgtt cctgaatcag 3103081 cggcttgggg cttgtcatcc agctcagtgt ccactaaata ttgtatcgcg ttttctgaca 3103141 gtcctaaata atatggaaat gattcgatca tttttttatc gaatggctca tgcggagggg 3103201 tctgaacctt tctctgccaa aatgcttcca gctgatcaat tcgttttccc cacagatcct 3103261 tccactggcc gattcttccg gccgccttca cctcatatgg atatcctcgg ccttttcggt 3103321 gaaattccgc aagctccgct ccaatggaga acgccctgtt tgaataaggg ggggccgcct 3103381 tcagcagagc gtacgttttt ccctcatgtt caaatgtcag ttcaccttct tttgtaaaga 3103441 taaaaaccga aacgtatggg tcactttgtt cttgtaaata ctgactcatg taataaagct 3103501 ccgccagctc tgtttctgag aattgggaaa cggggacaat cagaaagtat gaattaggcg 3103561 tctgaaagca ttgatatgtg tgctggtaca tggaaagctg cctgatgtga atgccgtatt 3103621 tttcttttat tgtacctttc accatgatca cctgcctgtt gaattagggc tcatcacatc 3103681 gtagtcatac acagccggaa ttatgaatac atattttaat ccgaagaagg cgcaagaaaa 3103741 agtcgtaaac ttctcaagca ttttgtataa actagtaaaa aagattgggt gaagctgatg 3103801 tcagaaaacg aacaattcag tcagatggaa gctaaagcaa gagcacggat gaaggagcgc 3103861 ggcgttgagg tatcagacat tgccgagctt gtcttttttc tgcagaaaaa atatcatccg 3103921 gatttaacca ttgatgaatg cacgctgaac gtcaatcgtg ttctcgcaaa acgcgaggtg 3103981 caaaacgcga ttttaacggg cattgaattg gatgttcttg ctgagcagaa aaaattgtct 3104041 gaaccgctgc aaacgatgct ggaaatagat gaaagcctat atggagtaga tgaagttctg 3104101 gcattttcca ttgtgaacat ttacggatcg atcgggttta cgaactacgg ttacatcgac 3104161 aaagaaaaac ccggaatcct taaacgattg aatgataaat caaccggtga atgccatacc 3104221 tttttagatg acatcgtcgg agcgatttcc gccgcggctt caagcagact tgctcaccgc 3104281 gcgcggcata cagaataagg gcaccctttt agggcgccct tttttcaaat gtatggaatc 3104341 cattcagtca gagagtcaat ggcgtgagtc ggtttttcca tatcgtctgt catatgttct 3104401 cttttcgtta cgcctgtgtg aacgagcagc gtatccatac ccgcgttaat gccggccata 3104461 atatcagtgg cgtagttgtc gccgaccatg agtgtttcag acacatctgt gccgagaacg 3104521 cgcatcgcct gctccataat aattgattcc ggcttgccga taaatacagg ctgtacacct 3104581 gtagatacgg ttaacaccga tgtcagtgag ccgtttcccg gcaggagccc tctttcagtc 3104641 ggaatcgcaa tatctccgtt agtggaaata aagcgggcgc catttctgat tgccaggcag 3104701 ccaacagcaa atttttcgta tgtaatggaa cggtcgatgc caacaacgac aaaatccgcg 3104761 ttttctccgc caaatgtcag gccgttttct tcaatcgcct ggcggattcc ttcctcccca 3104821 atcacataca cagacgcgtc ttttttctgc tgtgcaatgt gctgggcagt tgccatgctg 3104881 gtcgtgaaga cctgctcttc tgttgccgga atatcaaaag acacgagctt gtccgctacc 3104941 tgcttcggtg tgcgcgaaga gttgtttgtc acgaaaagat aaggaacgcc gcgatctttc 3105001 agcgttctga caaattcaca cgcctcctcg attttttccg tgccattgta catcgttccg 3105061 tctaaatcaa ttaaataccc tttatatgtt ttcatatcca acactcctgt ggctttccag 3105121 ttgttattta aacgcggaaa caggtcctag ctctgtttcc aaatagcttc tgatccgttt 3105181 cgggaagtcc tgaagagctg tttgatgcgc cttgatcagc ctgtaaagct cgccgctgtc 3105241 agcgagcaga tactgttgaa ccaacgtttt gcggtaggcg atcaattttt tgagctcatc 3105301 accctctttt tccgtgacaa ctttctcatc aacaagtata tccataatgt cgtcatagct 3105361 gcccgggtcc cgcataataa agccgtcaat catgtcattg cctgtatcca aaatgcattc 3105421 gattaacaga tggcctatac gctgaagtgc caattccccg atttcagact gccagtctgt 3105481 ttgtgagtca aatagcgcca gctggtgctc gaagaaccct agtgtttttt cgattttgct 3105541 tctgtcaaca aaatacatga cagcatcccc tttgtgtata tttattttct gatccgtttc 3105601 aagacaaaat acgcacagcc gaaattgcag tattcgtaaa tatattcatc taatgtgctg 3105661 attttcgttt cgaaggttgc cttttgattc tggtcgtcaa agaagccctt gagccttaac 3105721 tgaccgtatc cccagtctcc cacaatataa tcgtatttat ttaatatatc ggagtagcgg 3105781 gctttaaaag cctcttcgtt gaagccgtct ttgaaattgt gcaccaattc aaattcggca 3105841 ttttgaataa gaatcatgat ctcacctctt ttttcactca ttcctatcat aattcattgc 3105901 cccgtcccca tcaattgcta aagaataaat catgcgattt ggctacccta cacatgagga 3105961 gggattgata aatgaaacga accgctgtca gcctctgcct gctgaccgga ctattatccg 3106021 ggtgcggagg cgcaggattg gataatgccc aaaatgtccg gaatcagacg cagaatcaaa 3106081 ccaaacccat tcatgtgtcg gaccgcaacg aggcttttaa caggcataat gagaacgaac 3106141 aatttggcta tgtccgctat caaaaagaac aatttgacgg agaacagcag aaaacgccgg 3106201 tgatgaaccg ggaagaaacc gctcacatga tatcaagttt aacggttcag ctcccccata 3106261 ttcaagatgc tgcgacattg gtgactgacc gagaagcgct tgtcgtatac aaaaccgatt 3106321 ctaaaaaccg ggagctgacc gccgatcagg tgaaaaaaac agcggcttct gtgataccgc 3106381 gatactatca cgtgtatatt tccgataatc caaaccatat gcaatccgtc gaaaattaca 3106441 gcaatctcgg ctctggttca agggatatta gagagatcat gtcggggacg attcaagaaa 3106501 tgaaaacctc cccgcaagga agccctgtct cagagaatga aaatgccaat ggagaaacgc 3106561 gtcaggacat gaaaatcgat aggaatgaca aaaacgccag atgatctggc gttttggcat 3106621 tatgcttgtg cttgacgctt tttagatgct tcgtttactt gttcatccgc atggtaagag 3106681 gaacggacaa gcggaccggc ttcacaatgg ctgaagcctt tttgcatcgc gatttctttt 3106741 aattctgcaa attcatcagg atggtagtat ttttggactt tcaagtgttt cttcgtcggc 3106801 tgcagatatt ggccgattgc cataatatcc acgttgttcg ccaagaggtc gtccattact 3106861 tcaataatct cttcttttgt ttcgccgagt ccgatcatga tacttgattt tgtcggaatg 3106921 tcaggctgca tttccttcgc acggcgcaaa aattccaatg aacggtcgta cgtcgcacgc 3106981 gcgcggactc ttggcgtcag gcggcgaacc gtttcgatat tgtgattcag gatgtctggg 3107041 cgtgtatcca tcaaggtttt taggttatcg tagtttccgc ccatatcaga cggcagcacc 3107101 tcaattgttg tgaacgggct ttttctgcgg atcgcacgga cagtttccgc gaaaatgcct 3107161 gccccgccat ctttctgatc gtcacgcgca acagccgtaa tgaccgcgtg tttcaaattc 3107221 ataagcgcga ctgaatccgc tacgcgttcc ggctcttgca gatcaagctc agttggaagg 3107281 cctgttttga cagcacagaa acggcatgct cttgtacaaa cagaacctaa aatcataaat 3107341 gtcgctgtac gtctgaccgc ccagcattca tgaatattcg gacactttgc ttcttcgcat 3107401 acggtatgca ggttgttttc ccgcatgagt tttttgagcc ctgtatagtt ttcatttgta 3107461 tttaatttaa ttttaagcca ttcgggcttt ctgaggtgtt cgtctttctt tgccaattcc 3107521 catcatctcc aatatccaat atactcaatt tctgacacga aacattctga aaacgagaaa 3107581 ggtgcaggtt ttagttctgc aacaaaaata atgtttttct aactaaagaa agtcttttct 3107641 ttagacactt taacatagga aaaatttctc gacaagggaa gatgattact gacattttta 3107701 agccgggttg ccgcaaacta tgtgtattca atatgaaagg agattatttt gtgaaagttt 3107761 tgttatccgc tcttcttctc cttttgtttg catttgagcc ttctgcgtct ggaaaaaaac 3107821 tttcagatcc agtgctgtcg aaacggatgg aattatatca taaaatcgaa gctgtgacgc 3107881 agatcccttg gtatgcgctc gccgctgttg atcaatacga agaaaacgtg cggagcaacc 3107941 ggaaagatct gcctgaaaag gcgggaatca tcagcatcta tatacccgat gatatctgga 3108001 gcgggcctga aaacccgaat ccgaaagacg atgcgccgtt aagcattaaa gtgtttgacg 3108061 gaatcggaat ggatggcgat ggagacggga aagccgaggt cagcaacgat gaagatatct 3108121 tgtatacgtt cagccaatac ttactgtcgt atggcacaga tgaagacaac atccggatcg 3108181 ggctttggaa ttattaccgg cgtgatcaga cagtggggat tatatctgaa ttcatgaagc 3108241 tgtttaaagc ctacggccat attgatctgg gcgagcatgc attcccgctt ccgatcagaa 3108301 ccgattacag ctaccgaagc acgtggggag atgcccgcgg cttcggtgga aggcggattc 3108361 atgaaggtac ggatatcttt gcccattacg gccttcctgt caaatccaca tgttacggcg 3108421 tagttgaaat gaagggctgg aaccgcttcg gaggatggag aatcggcatc agggacatta 3108481 acaatacgta tcattatttt gcccatctca atgggtttgc caaagggatt aaaacaggac 3108541 aaatcgttga gcctggccaa gtgatcggat cagtcggcag ctccggatac ggcccgccgg 3108601 gaaccgccgg gaagttcccg ccgcatctgc actatggcat gtacaaagat aacggaagaa 3108661 ccgaatggtc atttgatcca tacccgcatt tgagggcgtg ggagcgatat gaataccaaa 3108721 aaaagaagta acaaaaagcc gcctcttcaa caggcggctt atttgctgct tttttctttt 3108781 tttgaatcgg caccgttttc tttgctgctc ggaagctgga cagaaggcgt gacacccgag 3108841 ccgccgcttc cattataaaa ctgcggcact tcgccctgca ctgctttaat cgatacagga 3108901 acattatttg tgacgacagc ggttttgctg gcaaatggaa tgatgacctt cactttaatt 3108961 tcgacaaaga tgctgatatc aataagtgcg ttatttatgc catacggctt gattttggtt 3109021 ttgacatctg taaaagcgtc accgattaaa ttgaaccgga ccgggatttt cggcccgagg 3109081 tttccaagaa ggctgttgcc ggttacctgt cccagcggaa tgttgatcat aatgttttca 3109141 ctggcgccgc tgtgtccggt atgggtttcc atctctttca aatgagcctg aagctgcttt 3109201 gtcacttttg ttttcacact gtttacaacc tgtgtattaa aatcgattgt cgttaagttt 3109261 ccgttttcat cagaattcat ttgaaacata tctttcatat tttcactgtc agacatatag 3109321 tcctcaatcg aatcctggat cacctctgtc gctatacgct tcgtttccat ctcgccgatg 3109381 tccattaaaa caggtttgat cgagccattg atcatccaaa ggctgaccgt tgttgacagg 3109441 ataaaaaaga caacggacag gagcatcacg taacggaaag gcaaaggtcc tctcttgcga 3109501 aaagggccgc gatatcttgg caagaaaatc cccccttaca tatcacaatg tatgcttgta 3109561 agaggggaca tagtaatagc cggggccaat ttattttatt tcatcatttt taaaagcgct 3109621 tctctgccgc tcatgccgac tttgatgcca agatcttccg cagcgtacgt gacggattct 3109681 aaaggtgcgt ctaacagctg gtcaatggtg cggacaccaa ctgcgcgtcc cgccacgatg 3109741 ccgcgctcct ttaatttttc attcagcagc gccacatcaa gcgcgccgca cataatgtat 3109801 ccgtgatcat tggcgacggc cataaaattc gttttgggaa gctttactgt cacagctgta 3109861 aaaggctgtc cttctatcat gatcggtgtc aggtttacca cgtcaaccac tcccttcatt 3109921 catcacttta tgatgaaggg cacagcttgt tgtgggctga ctgccttatt gtgcaagctt 3109981 ccaagcaagc agatcccgca aaaattccgg cataaaatat tctttttctg cagcgtcgcg 3110041 aatcaacgga aacagtttgc cgagcgtaaa catatcaagc accgcaacgg agtattgttt 3110101 atgtttttca atatcttccc cgttcagtgt gatccgagtg acgtgggtga tcccgtcatc 3110161 gagccgtttc gtttctacct caacgccggc atacaccatt ttccccatca cttctccgcg 3110221 gaagccgagt cctttgatcc ggagctgctc catttgttcg gaagcggcat ggacaatggt 3110281 ttccttcagt tcttctcccg tcaggcggac agccaccggg ttgatcggat gcggacagat 3110341 gcggtgcaga tccagctttg tcacaggacc tgcttttagc ggaccgagaa tgacacctga 3110401 attgaccata ctgatgtccg tctcgcacca ttcctttaag gcgtatgcca aaagcaaagg 3110461 cagctctgat tcttcaaacc acttcacctc agcatcttgt gcaagctctg caacggcatc 3110521 ggacagtttc tcctcggctt cacgttcttt ttcattgaga aacgctttag tttctgcgga 3110581 ttctcctgtc cattccgcca tgttctgcac agaagccgtt ttgctgttga tgcttcgctg 3110641 tacgctgtcc accgtgattt ctacacagcc gacataatgc ccgtatttct cggcgctggc 3110701 cagcagtacc ccattaacca cttgtccatc ttcgagcaaa tgatgggtat gtgattcgag 3110761 gattacatca atctcaggca ccgcttcagc cactgcttga tcatcaagaa tgcctaaatg 3110821 tgacagcaga acgataatat cagcctgccc tttcacttcc agaatggttt cctttatgct 3110881 ttcaagggca tccgtaactg tccatcccag cttgtcatat acaggataat acggcacagt 3110941 tacacctaag aaagcaatgg acataccgtt tttcaatgat ttgatatggt aaggcaccgc 3111001 ccaggacgga cggtttccat ttttatcaaa caggttagag acgatgacag gaaattcagc 3111061 atgatcatat aaggcagcaa gctcttcatg cggaagcgta atcccttcgt tattgccgat 3111121 cgccgctcca tcaatgtgaa ggcggtttaa gagatcgaca ttcgcttttc cgaatgtcgc 3111181 ctctgtcacg aattgaaaac gatcaagatg atcgccaata tcaaaaacga gcgtctcttc 3111241 gccgtctgac tgatgctctt ttcttttctg ctcgatataa tctacaattt tcggccagtt 3111301 ttcaaaatgg ctgtgcaaat catttgtatg atataagcgg agcttctcct tcataatatc 3111361 tctccctaat cgttcagctg aaaatgcctt cataaatgag ctggcagccg atcaaaatca 3111421 atacgatccg catgatcata acgatcgttt tcgtctgcat ttttctgttg atggcggcgc 3111481 caagctttcc gccgaaccaa gcgccgggca caagcgcgag ggcgtacagc caattgacgt 3111541 gcccggaaat catatgtgaa acagaccctg tcatagaaga caggaaaata ataaacatgg 3111601 acgttgccac cgcaaccttc ggcggaaaca gaaataacag catcatcgcc ggaaccatca 3111661 gtgatccgcc gcctataccg aaaagtccgc ctaaaaaacc gacaacaaag gcaatggcaa 3111721 taccgacaga ggcctgatat gagtacgtat aaggctcacc ggcatcatcc tgaaatgtcc 3111781 ggataattcc tttgtgcgct ttgttgattg gccgggcttt cgctttcagc attaaggata 3111841 atgaaatcag aatcataaaa atgccaaacc aaacggaaaa cgagtttgaa ttgaacagct 3111901 ttgacacgta agccccgatc atgctgccgg gacccgaacc gataaagaaa atgagtccgc 3111961 tcttataatc aactgtttta tatttaatat aagccaaagt tgaagaaagg cccgtaaaaa 3112021 taatgaccaa aagcgaagtt ccaatcgcaa cctgcggcgt cacatcctga aacagctgcg 3112081 tcactgtgct taaaaacatc agagatggca caatgacaat tccgccgcca agcccgatca 3112141 gacttcctac cgtacctgcg attaatccca gtacgaccaa aatcacaaac gacatcaatc 3112201 aaaacctctt ttctaaaata aatcgagctg tctcggagca agtccgctgt actcgatatc 3112261 aagcagttca agcatctgct tgccattatc cgcagcgtca ccgccggaat tgttgttgaa 3112321 caggacaaaa acatccttac attgctgctg caattcattc aggtgctttt tccaatcctc 3112381 cagctcctgt tggttgtagc ggtataagta cctgacctcc cgccagtttt tcccgccatc 3112441 aggcttcatc cagccctgct tgttgcgtcc gtgaaacctg acgagcgttt tgttttcatc 3112501 ggtcgcgcgc aacacggtcg gaacgctgcc ttctccgatt tgcggttcat cacagacact 3112561 gtgaatccag ccttccgctt tcataaatga aagcgtctgc tcataaaatg gcggcgagaa 3112621 ccaggaacgg tttctgaatt caagcgcgca aggaatatct cccatttggt gcttacacca 3112681 tctcaaatag gcgacattct ccttcttgca gtcaaaccac ggcggaaatt gaaacagcac 3112741 catggcgagc ttattgctat gtaaatatgg cgttaaagac accttaaacg catcaaacat 3112801 ctcctctttt gagtcaaagg gaatttcgcc gcgctgatgc cctgtcatgc cctgatatgc 3112861 tttcacgata aattggaagg tttcgggcgt ttccttcacc cacttttcat tattgcgcgc 3112921 cggctgaatc gcgtaaaagc tcgcgtctaa ttccacgatc ggaaaatggg aggaataggc 3112981 ctgcaatttt ttctggctgg ccgttttcgg cggatagatg ctgtcatgat ccccccatcc 3113041 cgtcagtccg atataaatca cactcattca cctctcttcc agtttatcac acgtgttttc 3113101 aggtttcctc ggaaatgctg ttcatatggc gggaaaatgc ctcacgcaaa tgctgatatt 3113161 gttcctcatt cgtatctaaa aacgcctctt ctcttgagga aggaatgtgc tgatattcaa 3113221 taggcgcctg aaactgctca ctcgtaaaat cgtacaccac accattgatg ctgttataaa 3113281 aatgccagct ctcatcgact cttgttttga aaatcgtgcc gccgaaatgg tcttgaatca 3113341 ccaatgccgt cacgccgcat tggccgcatg acgggcattc ttccgtccat ttagagctcg 3113401 aatggcgcga ccaggattgc ttaagtatgt atttgacatg ctccattgcc tccgcctcct 3113461 ttaaaaaaag ataccacgtt gatgagattt taaaaactag aacggaggaa atcaaaaaac 3113521 ccggcggtaa aatccgccgg gcttacgaag gaacgaccag agctccgtca atttcagtga 3113581 ctttttcccc atcattgtac acgcaccggc ctttgctgta agtggccgaa atgctgcagg 3113641 gaaatgtatg tccttcgtaa atgctttttt tatgctttgc aaacatcgat tctcttgtaa 3113701 cagtgtacgg ctccatgctg acgagcacga aatctgcatc acaccccgcc tcaagccgcc 3113761 cttttttctg aaggccgaat cgttttgcag gggccgccgc tgtccattct gcgatggttt 3113821 caaatggaat ctgatgctca agcgccagtt ccagcattcc taataaagtg aactgcccgc 3113881 cgctgattcc gccccatgat aaaaacatgt tatcctcccg cttcaaggat ggacggcaag 3113941 gggaatggtc tgaggaaacc atgtcaatgt ccccggcaat gagcgtctcg atcagcgtct 3114001 cttttgattg ccgtgaccgg agcggaggcg cgcattttgc gacagagccc ctttgccgta 3114061 aatcgtcatg gctgaacaag acataatgcg gacatgtttc aaccgaaaca tcaagacctt 3114121 cctgtttcgc ctctctgatc agccggaccg ctttcgccgt gctgatatgg acaaaatgaa 3114181 ccggacagcc tgtcaccttc gcatactgaa tcgtgcgata caccgcttca acttctgctt 3114241 cctccgggcg ggaggcggcg tacgcatccg catccacctt tcctttattg gccaaaacca 3114301 tctgcaagta gcttgtgatc gcgtcgcttt ccgcgtggag agcgaggatt tttcctgcag 3114361 ccgcgatttc tgccatgcct ttgagcaatg tccgttcatc aacagagcgg aactcatcag 3114421 tgcctgactt tgataaaaac gctttaaacc cgatcgctcc cgcttcagcc atcggacgga 3114481 tgtcctcgat atggcctggc acaaggccgc cccatagcgc aaaatccacg gcagattttt 3114541 gcctgcctag ctcagctttt gcgagaagat gctctgccgt cacggttgat ggaatacagt 3114601 tgagcggcat atcaaaatag gtagtgcaac cgcctgcggc catcatttga gaacctgttt 3114661 caaacccctc ccaatcctcc ctgcccggtt cattaaaatg aacatggcaa tctatcacac 3114721 caggaaacac gtatttcccg tctgcctgga tgatttccgt cccgcttgct tcaatgtcag 3114781 aacctatctc ggcaatgaca ccgttttgaa ctacaatatc agcttctata acgccatctg 3114841 gcgtaactgc cttcgcacct tttatcacca tatcgtaagc catattgatc cccccatgtc 3114901 aggatgacga ttttccatgt cagtttatgt aacacaacca gttctatttt caacagttta 3114961 ctgctactat gatcgtatta catcagcaaa accgctagaa ttcctattga aaattattca 3115021 ccttaaccaa tgtttttata gaaaaggaga atgcgctatg aatattcttg atgtgatgaa 3115081 aataccggct tttgaaaacg ccaatttaat cgctggaaaa gcaggagggg aaagagaggt 3115141 tcagcatgtc aatatgatgg acgctccgga tatcgtagac tttttgcata agaatgaatt 3115201 gctcgtcacc accgcctatc acctgaagga tcacccgcat caattatctg aactgattcg 3115261 gcaaatggca aaacgcggct gcgcgggcct cggcattaaa acaaagcgct atctggaaga 3115321 tatcccgaag gaaatcatcg aactggccga ttcatatgcg tttccgatca ttgagcttcc 3115381 ggaacacatc cgactcggcg atattgtgaa tgccacactc agccatattc tcgatatgcg 3115441 ttctaacgag ctgcagcaag ccatttacgc gcacaaaaaa ttcacaaacc acattatgag 3115501 cggcaagggg ctgcaatccc tcctcaaaaa ggtgtcagac atccttcagc ttcccgtgct 3115561 gctgcttgac cagcatgcca aaatgctgtc tgcgtctcat cagatttcag ttgagaccga 3115621 aaagctgaaa ggcaccctga ataccgtatc cgggccattt ttcacttgtt tctctacaat 3115681 ctcagatcag aaaacatatt ctgtcctgcc tatttataat cacgaaaaaa actgcggcta 3115741 cctgctgata cccgacatgg tgcaggcagg cgacaaagga ttgatcctca cgattgaaca 3115801 agcggccaac gtcatttcct ttgaactgct gaaggaaaat gcgctgaagc agttcagccg 3115861 gcgggcccgc aatgagtttt tcaacaattt tattgagcgg accttttctt cagatgacga 3115921 aatcaaaaac cgggcgaaag aattcaagct gcgctgggat caaaaataca tgtgcatcgc 3115981 cggcaaactc gatcgcaatg acgaatcaat cagctttaca gaaaatcagc tcgcttccga 3116041 cagcgtattc gaatttcttg aaggtgaatt atcagccttc ccgtttccac ctcacttctt 3116101 tatgaaagga aatgtcggca ttattctaat cgaggcgaca gacagctgga gtgaaatgca 3116161 cgcctcggtg atcagctttt tagaacagtt tcaaacacag gtcagcgctc aatttaaacg 3116221 aaccgtgtcc tttggcatca gcaatatctg ccaaaagctc attgatgttc ccgacgcttt 3116281 cacagaagct tctgatgctc tgcaatcggg gcatttgtca agaagcaccg catttatcca 3116341 ggtgtatcac gccaaagatg tgcctgagct tctgcgcttg ctcccagttg aggatttgaa 3116401 gaaattttac aactccacgc ttcagagcct cgctgaaaaa cagcaggagg atcaaagcct 3116461 gcttcatacg ctttccgtct atttagagac acactgccaa atttcagaga cggcaaagcg 3116521 tctgtacgtt catcgcaata cggtcatata ccgccttgaa aaatgcgaag agcttctggg 3116581 gaaaagctta aaagatcctg aaacaacgat gcgtttgcgg cttgcattac gtatgcagcg 3116641 gctgatcagc taaagtttgt tacattttct tacaaaacga atcgtttttc gtcactttca 3116701 gcaatcacac ctgtcttttt cagctactgt atccaatgac acccctcgac cggaacgata 3116761 ttatgttact aaagttcaca tacagggagg gactatagtg aaaaaaagat cgtttaaggt 3116821 gtttacactt agcctgcagc atgtgctcgc catgtatgca ggtgcgattt tggtgcccct 3116881 gcttgtcggc agggcgctga atgtaacaac tgaacagctg tcctacctat tggcgattga 3116941 cctgttaaca tgcggcgtcg ctacgctttt gcaaaccttg cgcggaacat acatcggcat 3117001 cgggcttccc gtcatgcttg gcagttcatt tgtggccgtc accccaatga ttgcaatcgg 3117061 cagcaattac ggcattcacg cgatttatgg ttccatcatt gcggccggtg tgttcatctt 3117121 tttgtttgcg cgttttttcg gcaagctgac tgtgttattt cctcctgtcg taacaggtac 3117181 cgttgtgacc ttgatcggcc tttcacttgt tccgacaggt gtgaaaaata tggctggcgg 3117241 cgaaaaaata aacggcagcg ccaaccccga atacggttcg ctcgaaaacc ttcttctctc 3117301 tgtcggtgtc cttgttctga tcttagtcct caaccgcttt ctcaaaggat ttgcccgaac 3117361 actgtccgtt ctgatcggca tcgccgccgg aacagcggca gcagcgatca tgggcaaagt 3117421 cagcttttct tctgttacag aagcaccgtt cttccaaatc ccgaagcctt tttacttcgg 3117481 agcccctgcg tttgaaatcg gtccgatctt aacgatgctg atcgtcggaa tcgtcattat 3117541 tgtggaatca accggcgttt tttacgcaat cggaaagata tgcggcagac ctttaactga 3117601 caaagatctc gtcaaaggct atcgagcgga aggaatcgcc attctcatcg gcgggctgtt 3117661 caatgccttt ccttataata cctttgcgca aaacgccggc ttattgcagc tgaccaaagt 3117721 gaaaacaaga aacatcgtcg ttaccgcagg ctgtatcctt gtctgtctcg gactgattcc 3117781 gaagattgcc gcccttgcat ctgccgttcc tgctgctgta cttggcggcg cgaccgtcgt 3117841 catgttcggc atggtgattg cctccggcgt caaaatgctc agcacagcgg atctcaaaaa 3117901 tcaataccac ctcctgacca tcgcatgctc aatcgcactc ggcatcggcg ccagcacggc 3117961 ccccgggatt tttgctgaat tccccgctcc gatccggatt ctggtcagtg acggcaccat 3118021 caccggaagc ctaaccgcca tctttttgaa tctatttttc agcttgcgcg acaaaaaaga 3118081 attaacagca cagcaaacag aacttccggt attagaacat acactcgcat tagaaaaaga 3118141 ggtgtaaaaa agatgaagga acagcacaat gccttacagc taatgatgct ggggcttcag 3118201 cacatgcttg ccatgtatgc gggagccatt ctcgttccgt tgatcgtcgg agcagcgatc 3118261 gggctgaatg cggggcagct gacgtattta atcgcgattg atttgtttat gtgcggggcg 3118321 gcaactcttt tgcagctctg gagaaaccga tatttcggca tcggccttcc cgttgtgctc 3118381 ggatgcacgt ttaccgcagt cggcccgatg atttccatcg gaagcactta cggtgtccca 3118441 gcgatatatg gtgccattat cgccgcagga ctgattgtcg tcttagccgc gggcttcttc 3118501 gggaagcttg tccgtttttt tccgcctgtc gtaaccggat cagtcgtcat gatcatcggc 3118561 atcagcctga ttccaacggc aatgaataac ctggccggag gtgaaggaag caaagaattc 3118621 ggctcactcg acaacgtgct cctcgggttt ggcgtcacag cttttatctt attgctgttt 3118681 tatttcttta aaggctttat ccgctccata gcgattttac tcggtcttat cgcaggaaca 3118741 gcggctgcat atttcatggg aaaggtcgat ttttctgagg ttttggaggc gtcttggctt 3118801 catgttccgt ctctgtttta tttcggaccg ccaacctttg agctgccggc tgttgtcacg 3118861 atgcttctcg ttgcaattgt cagcctcgtt gaatcgacag gcgtttattt tgccctcgct 3118921 gatatcacaa accgcaggct gtcggagaag gatctggaaa aaggctaccg ggcagaaggc 3118981 cttgcgattt tgctgggcgg cttatttaac gcgtttccct atacagcttt ctcgcagaat 3119041 gtcggcatcg ttcagctctc aaagatgaaa agtgtcaacg tcatcgccat cacaggaatc 3119101 atactggtcg cgatcgggct ggttccaaaa gcagcggccc tgacaacagt gatccccacc 3119161 ccagttctcg gcggcgcaat gatcgtcatg ttcggcatgg tcatttctta cgggatcaaa 3119221 atgctatcca gcgttgacct tgattcgcaa ggcaacctgc tgattatcgc ctcttccgtc 3119281 agcttggggc ttggcgctac aacagttccc gcgttgtttt catctctttc gggcgcggcc 3119341 tctgtcttgg caggaagcgg aattgtgatc ggcagtttga cggccattgc actgcacgct 3119401 ttttttcaaa ccaaacagcc gaatagcgca gacataaaaa cgtaaaggaa gatgccaatg 3119461 ttcacaatgg atgacctgaa ccaaatggac acacaaacac tgacagacac acttggctct 3119521 atttttgaac actcttcatg gattgcggag agatccgcag cactacggcc gttttcgtcc 3119581 ctttctgatc ttcaccgcaa aatgactggc attgtaaaag ctgcggatcg cgagacacag 3119641 cttgatttaa tcaaaaagca tccccggctc ggaacaaaga aaacaatgag cgatgactcg 3119701 gtacgagagc agcagaacgc agggctcggc aaattagaac agcaggaata cgaggagttt 3119761 ctcatgctga atgaacacta ttatgatcgc ttcggctttc cttttatttt agcggtgaag 3119821 ggaaagacga aacaggacat tcaccaagcc ctgctggcaa ggcttgagag cgaacgagaa 3119881 acggagttcc agcaggccct tatagaaatt taccgaatcg cccgctttcg tctggctgac 3119941 atcatcactg aaaaaggaga gacgcaaatg aaaagaacca tgtcttatgg caaaggaaat 3120001 gtatttgcat accgaacgta tttaaaaccg ctcactggag tgaagcaaat cccggaatca 3120061 tcttttgccg gaagagataa taccgttgtc ggcgttgatg tgacatgcga aattggcgga 3120121 gaagccttcc tgccatcatt tacagacgga gacaacactc tcgtcgtggc aacggattca 3120181 atgaaaaact ttatccagcg ccatctcgca tcctatgaag gaacgacaac cgaggggttc 3120241 ctacactatg tagctcaccg atttttagat acctattctc atatggacac gatcactctg 3120301 actggcgaag acattccgtt tgaagcaatg cctgcatacg aggagaaaga gctcagcaca 3120361 agccgcctcg tcttcagaag atcgcgtaat gaacgaagcc gctctgtgct gaaagcagaa 3120421 cgaagcggga ataccataac gattacagag caatacagcg aaatcatgga tcttcagctc 3120481 gtcaaggtga gcggcaactc cttcgtcggc ttcatccggg acgaatatac gactctcccg 3120541 gaagacggca accgcccgct gtttgtctat ttaaacatca gctggcaata tgaaaataca 3120601 aatgactcat acgcttctga tccagcacgc tacgttgcgg ctgaacaagt ccgcgactta 3120661 gcgagcaccg tttttcacga gctcgaaacc ccttcaatcc aaaacctaat ctatcatatc 3120721 ggctgcagaa tattagcgag gttcccgcag ctcactgatg tcagcttcca atctcaaaat 3120781 cacacgtggg atacggttgt cgaagaaatc ccgggctcaa aaggaaaagt ctacaccgaa 3120841 ccgcgcccgc catacggttt ccaacatttt accgtgacaa gagaagacgc cgagaaagaa 3120901 aaacagaaag ccgctgaaaa atgtcggagc ctgaaagcct gatgggaaaa ctgacaaccc 3120961 atattttaga tttaacctgc ggcaaaccag cggcgaacgt aaaaattgga ttgaagcggc 3121021 tgggcgaaag tattatgaaa gaggtataca ctaacaatga cggcagggtc gatgtccctc 3121081 tgctggctgg tgaagagctg atgtcaggag agtatgtgat ggaatttcat gcaggagact 3121141 attttgcgag taaaaacatg aacgcagccg atcagccgtt tttaaccatc gtcaccgtcc 3121201 gttttcagct agcagatcca gatgcacatt atcatatccc gctcttgctg tcgccgtttg 3121261 gttatcaggt gtataggggg agttaagaag gaagcccgcc tcaccggcgg gcttcttttt 3121321 gcacttcaat taacttttga tcctaggaca gtacttgaag tgatccccac acttagtgaa 3121381 acaacagcta gaataaacat tcacctatat ttttcaggat aattgcctac gagaaaaata 3121441 ccctgtagtc ctttcattta taaatcgagg tttcaaacta ataagtcagc tcttagcagc 3121501 cgagctccct tctccaatcc tataaacaga ccgcgttttt tctcgaaaaa atactctgaa 3121561 gacaattgct gcgtttttaa tagttttgat aacgcgttct ctcttacacc tttagacaaa 3121621 atattcattt tttctttttt agacttaaat ctatgtcgaa aataatcgtt ggcatatctt 3121681 atcctatctc cactaaagga ggtgacatta tgggattcta caattctggt ggatacagtg 3121741 gaaactctgg ttactcaaac ggtttcggga gctccttcgc tttgatcgtg gtgctattca 3121801 ttttgttgat cattgttgga gcagctatct ttaattatta agtttaactt tccttgcctc 3121861 cgccgtatcc aacacctccc tgtccgacag acgccataag aagtttttat ggcgtctttg 3121921 ctatgtgttc actaatcttt ttgtaatcca gaagctgtca agttctacga gatttatcgt 3121981 gtgttttccc acaacgcttc tgcgtcttga tcgcgctgtc tgactgaggc taaaaaagtc 3122041 cggcttttaa aagccggact cccgtctacc cccgttcaac tctcttctaa tcctgcaagc 3122101 tgaccgcata atcccgccat acccggtaca ccggcacaaa ttccccgcca gcccttcttc 3122161 tatatctttg tcagaaggtt gaggggtttc ccgaaacaat gctttaagcg caatgatcat 3122221 tcccggcgta cagtagccgc attggaagcc gccttcttcc aggaaagcgg tttgacacat 3122281 atccagctct tctttttgaa gcccctcgat ggttgtgatg gaatggccgt ctgcttgata 3122341 ggccatcgtc atgcacgcat tggccagttt tccgtcgatt aaaatagagc aggctccgca 3122401 gcggccgatt ccgcaggaca cctttgtccc ggtcagctga aattcctttc taagcaggtc 3122461 actcagatgt gtcgtaggaa cggcagcaac ctcccacgcc tgaccattca cggtcatccg 3122521 gaactgttcc ttttttacag gaaatggccc ggcctctttt atgtccattg cttcagcccc 3122581 tttctgtcga tcgcttcaag caactcttct cttgaaattg gcagcttgtt tatccagcat 3122641 ccgaccgcat catgtactgc ctttacaatc gccggagtga tggcgattgt tccgatttca 3122701 ccaacaccgc gcggtccata tacgtctccc ttcattaagt cttctattgc aatcagcttc 3122761 atgtcaggaa catctttgat tccgggaatc aaatagtgat cgagattttc cgcagcataa 3122821 cggccatccg tcattttcgc ttcctccatc agtgtgtagc cgagtgccat ggcagcgccg 3122881 ccttcaattt gacctcgata tccctgcgga ctgacaaccg gacctgccgc aatagcgtgc 3122941 tcacaatcta tcaatttgac atcgcctgtt aacagatcta cctccacctc aacggcagcc 3123001 gctccaaatg agtagaggaa atggccgccc accacaggat caggcgttgt tggaaagtca 3123061 aaggccgttt cctctgccaa agggcctttt tcagccagct ccttatacgt caccacgagc 3123121 gcctttgtgt ttttgtcacg caagcctgca gcgccgggaa taagattttc cgctgaacag 3123181 ccgctccatt ctgccgcccg ttttttcaac tgagctagaa acggcttctt caaacgctgg 3123241 atcgcgtgcc acaccatgct tgtgccgcgg gatgctgtgg aggagcctga cttcggcact 3123301 tttgcggtat ccccaataac aatggaaata tcctctgcgg cacaacccag ctcctccatg 3123361 acaatctgtt caatcgctgc tagaatcccc tgtccgcatt cttcaaatcc aaacgaagca 3123421 gtgattttgc cttcactcga aagagacaaa cggcctcctg ccgcatccat tcggccaaac 3123481 cccagcccgc cgccgtgcat tgtaattgcc gctcccgtgc ctctttgcag atacccgcag 3123541 ttccggcttg tttttttaag aatgggagat ttagatatgg cattcaacac ctgtgccgct 3123601 ccgtcagttg gtgcaattcg atgctcaagc ggccccaagt catgcggttt tctgatattt 3123661 tttcttctca gctcgagcgg gtcgatgcca agcatgccgc tgagacgatc gagatgggtt 3123721 tcgagtgcaa atgtgatttg gttgccgcca aagccccgaa attcccccgc caccccgttg 3123781 ttcgtaaata ctgatattcc ttcagtccgg atattcggaa tacggtacgg ccccgcggca 3123841 tgctcgacag aaaaatcaag aacagccggt ccgagcgtag cgtaagcgcc tgtgtccgcc 3123901 acaattttca cgtcgtgcgc caatagattt cccgaatgat ctgcacccgt ttttatcgta 3123961 atcttcatcg gatggcgctt aatgccagaa cgtacagatt cctttcgtgt ctgatgaatt 3124021 ttgacagggc gtccgctttt cagggccaaa agcgcagcat acggctgaat attcagctca 3124081 tccttccctc cgaacgagcc gcccatcgga cttgacacaa ttctgatctt ctcttcagga 3124141 atatcaaaaa tacgggcaag ctggaaacgg tctttatagc cgtgctgggt tcctgcatac 3124201 atcgtaaaac ccccgtcgtc ttccggaacg gctacacctc cctccgtttc catatacgta 3124261 tgcatctgcc gcggcagctc ataggtttct tcaaagactg tgtcagatgc ttgaaaccct 3124321 tcttccacat caccgtttga aaaaaatgcg cggtgcagga tattcccgtc ctcatgcagt 3124381 ctttgcgcat tcggccgaag cgctttttct ggtgaatcca tgacttccag ctctttatac 3124441 tcaacttgaa tcagctccag cgccgcttcc gcgatttctt ccgtttccgc agcaactgcg 3124501 gcgatcgcat ccccgacata ccgcaccctg tcctcacata aaaccggctg atcagggatg 3124561 acaatgccaa atcggtttaa gccgggaacg tctttatgtg tgacgacggc ctgcacgcct 3124621 tccattttct cagcttttat ggtgcaaacc gacacaatct ctgcatgagg ataagcactt 3124681 ctcagcacct tgccatacag cattcctgga aagctgagat cggtcatata tttcaattcc 3124741 cctgtgacct taccccttcc atccggcctg actcttgacg gtttgttgat gatcatttat 3124801 tcccctccct cagccatcag ctctgccatg atgacgttgg cagcggcttt ttttctgtat 3124861 gccgctgaca taaaaacatc tgaggaaaac ggcagctcat ggataagtgt tttgtacagc 3124921 tcatgcgggt cccaccctgg tgccatccat ttcgcttcgc tgtccaataa tctcctagga 3124981 gtgatatcgg catggccagc ggcgaggcga atgctgccgt ctttcaaaaa acgtccagct 3125041 gcaacagcag ccgctccggt aaaagcctgg cgccttccaa gcttgtgata aaatacacgc 3125101 tctccctccg cccgcgggat gatgacacgc gtgacgatag ccgttctaaa gtcttcctca 3125161 ctgagccaag cgccaagcgg cagcctgatt agctcctttt gatatacgat aagctcagca 3125221 ccaagcacaa gcagaagcgg aatgaaatca ccgattttac tcgctatgtt gccgccaatc 3125281 gtggcacggc tgcgaatccc cggtgcagcg acagcggaag cagcgtcact gaaacagcta 3125341 agcgctctct taatcaaagg gttctttctg cattcattca gtgatgtgag ccccccgatc 3125401 gacacgtggg tgtcactggt gctgatccct cgcatttcgt caatcccttc aaggctgaca 3125461 aggtgctgtt tcggtagagt tcctttgtcc cactgaagct gaaggagcgt gcttcccgat 3125521 gcggcacaca catccggagc aagcttctct aaaagcgaat aggcctcatc aagcgctgcc 3125581 ggtctccata attgaatatt catccttgct tttgtcactt ggccgttcaa gacatcgccc 3125641 tccttaccat gtcatattcc tcgggtgtat caatatcgtc caactcaccg ctatcctttg 3125701 cctccaaaac cgctcctgct ccaagctgtc cgcttttcag gagcctgcga gccccttcat 3125761 ctccctttaa tccctttaca taaggaaaac atgtcgacga gaagtagatt ggcggggtga 3125821 acgcccctaa aaacgatgac acggcaaatg actcaggagc cagagccaca agggcattga 3125881 gatgatcgac ggaaagctga ggctggtcgg ctaacaaaat gacaatgccg tccgccccca 3125941 tgctttctgc ttttctcacc ccgctgctga ctgaatgccc ctgacccttt tctgcgtctt 3126001 ggcaaacgtg caggctccag cgtttttgaa aaggcggagc gtgatacggc gctcctatcc 3126061 actcaaggga ggcatgttct gtccgctcga cgaccagcac gtgatcaagg cgggacgaca 3126121 gagcagtttt caaggaaagt gagcctatgt tttctccttt tagcggcaaa gccagcttgt 3126181 tttgtcccat tcttctgctt ttgccggcag cgagaaacac gccgatcaga taggggcttc 3126241 tcatacaacc gccacccgtt ttcttgtttg aatgatttct gcaactacac ttaccgcaat 3126301 ttcctcggga ccttccgcac cgattttcag cccgaccgga ctgtaaaagt gagacggagg 3126361 atgttttccg ctcagcagcc gtttcgtgcg gtttgccgaa cccaacagtc caatataatg 3126421 gaggttttga gaaaataaga agttgatgat cgtttgatcg tgctgataat gatgggttgc 3126481 cacaacagct gcatcatgcg gaaaaaattg aaattcgcta agcatttgtt ccggaaaagc 3126541 ggtgatcagc tgatccgctt ttggaaaaag agaggatgta caataagcgg gccgccaatc 3126601 cgtcacgata acagaaaacc ctgtgtcagc cgccaaattg gccagcggta cattatccgg 3126661 tcccgcccca aacagaatga gacgcggctt cggttcaatt cgctgaataa acatgttagt 3126721 ggtttgatcg aaatgcggta aatgaagcgt tgaaacagta cgttgaatat cttgcagagg 3126781 cgcgtccggc cagttcccaa aatgtccgtt ctccgtcaga aataaataat gggaggattc 3126841 aatctttata acggaagtga cagctttgcc tgaatgaagg cagtccctca ctttctcata 3126901 gtgccgcctt ttttcctgag tgattcgctc tgcatgaaca tgaataatgc cattgcaccc 3126961 ggctcccatg ccccaagaaa gatcgtcctc cgaccgcatg tcgtagggaa tcagcgttga 3127021 tgtgagctga tcgcccagcg cactgattct ttggaataca tcttcttcca cacacccgcc 3127081 gctcagcaag ccaatccgtc tgcctttttt cttaaagagc atagaggcgc ctgcttttcg 3127141 atacgcggag ccttcaactt gaacaattgt cgccagtaca gcctcctcct ggtcttccag 3127201 gagcgcatct aacatcgtgt gaaaattccc caatgccgca tcctcctctc gaaaattgcc 3127261 gtgagaaaca actagttcag cgtgatttta taggtaactt gtataaagaa tagacgatgg 3127321 aagaaaaaat gactcatgat ttgtcagaaa atgaaacaca tagaaagagg atttgtaaaa 3127381 agagtcaaac gaagaaaatc agattggaga aaacacgaaa tcatatcgtt aaaaagcttg 3127441 cggagttccg caagcttttc tttacaccgc tgcctggcgg ccagcgtttt catacacatc 3127501 cagcgctgct tggagcgctt ttcctgcttc gattcctgcg ttatgtctga gaagcacagc 3127561 ctctaacccg gcaagcacga atagcacgtt ttcttttctg cagctgtacc ccatcgtgcc 3127621 gatcctccag atcttccctg caagcgggcc gaatgagctg gcgatttcaa tgccgaattg 3127681 tgccagcagc atgtcacgga cagactcgcc gtcaatgccg ccgggaattt cgacacaggt 3127741 gacaacaggc attttgcagc tgtcatctcc aaacaatctt agccccattg cctttatccc 3127801 tgctgctaat gcggcttcat ggtgccgatg ccgctcgaaa cgcgtctcaa gaccttcttc 3127861 aagcaccagt ctgactccct cacgtaaggc gtacagcatc gtcgtcgctt ctgtatgatg 3127921 attgagccgt ctttcgctcc aataatcctc aagctggctc aaatcaaagt agttgcttgt 3127981 aattggccga tttcccgaaa gtgctgccct gtcagcttgt gtcgcaatcc cgcgttccac 3128041 ctttttgcga gctgcaatca cgtccgccac ccgctcatta tatgtaatcg gcgccattcc 3128101 tgaaggcaca gacaaacatt tttgcgttcc gccgatggca gcgtcaatct tccattcatc 3128161 gactttaacc tcgcagcccc caatcgttgc gactgcatcg acgataaaca atgcatcctc 3128221 ggtgcggcag gcttcgccga tggctttcag cgggtgaatc cgtcctgtcg atgtttctcc 3128281 atgcaccatg gccacaattt tcggcttcac tttttttatc tcccgtatga tgtcctccgg 3128341 gtcaaaaacc gttccccatt cgcactccag catatgaaca tttgccccat atcgctcggc 3128401 gatttcagtc agcaaataac cgaaacggcc gtaaatggga atgagcacat catcttccgg 3128461 ctctatcaca ctagccagca ctgcttcaat tcccgcccgt gaagtgccgt caatcgggta 3128521 tgcccagcgg ttttttgttt ggaacagctc ccgaagcatc tccatcgttt cattcataat 3128581 acctgtaaac gccggatcaa attggccgac aaccggggtg ctcattactc ttaatacacg 3128641 cggatcaacc tcaacaggcc ccggtgtcat aatcgttctt aacggggtgc ataattctct 3128701 tctgcctgac acagccattc ctcctttatc agtaagccag tttgtataat aaatcagtca 3128761 gtgcgcggac gccgatctca agctgtctgg ctgacgtata ttccttcggt gagtggctga 3128821 cgccgcctcg gctcggcaca aacagcatac aagcaggata gcgccttccg atcatttgcg 3128881 cgtcatgccc tgctccgctc accatttcct cacagctgaa gccgttttct aatgctgttt 3128941 caaaagccgc agccttcagc ctttcgtcca tcggcacagg ctctatccgc atatattcat 3129001 caatcacagc gcgaattcct ttttgtaggc aaatgccgtt gatcaaagca accatgtctt 3129061 gatgaaactg ttccagcaca tgctgatgct gatggcgaat atcgattgaa aactggacgc 3129121 ggcccggtat gacattggct acattgggct ctgccgttat ttttccgcat gtcagacgga 3129181 gctcatccgg cagctcatcc gaccgcagca gcagctcatg aatgatacgg ctgctggctg 3129241 cgagcgggtc cttgcgccat ttcatggagg tggttcctgc gtgattgcat tctccttcga 3129301 gcgtgacgag atatcgtctc tgccccgcaa tacttgtcac gatgccgaga tcccggcctg 3129361 acatttccaa cgtcttcccc tgttcaatat gcagctcaac aaacgcgctg atatctgtcc 3129421 tatatgctga ctgaaacaca cctttgccaa aaccgctctc atgcatcgct gtttggaggg 3129481 agactcccga ctcgtctctt ggctcttttg catcttgttc tgaaaaaaca cccgtcatat 3129541 tccccgaccc ccaataggtc attggaaaac ggctgccttc ctcctcacat aaggagaccg 3129601 cctcgagcgt tttttttggc gctccgtatg tttccttgag ctgctttaac gcgagcattg 3129661 ccgccagaac gccataggcg ccgtcgtatt ttcctccatt gatgacagta tcgatatgtg 3129721 aaccggttac aatgacttca tccggagact gggtgcccga aagccttcca aacacattgc 3129781 cgacatcgtc gaatcttgtt tcaagcccga aagaagacat ttccgttttc acagcaagct 3129841 gtgcgtccat ccactctttt gtgtataaaa gcctcgttac gccgccatcc gcagacgcac 3129901 cgtattgggc gagccattca atataatctg tgatgctgtt ttttactgaa agcttctgct 3129961 tttccatgta ctcccccctc tggccgctat ggtgacttca ttatagaagg agcaacatga 3130021 tagttcattg acagattaac caaaaaaacg tttatttttt agccacagta tccatccagc 3130081 aaccagatac accctacatg tcacaactat tttgatgtaa aggtcaaaag aaaacacggt 3130141 aaggaagaga gccagcaaga gcgaaagaga gggtcaaaat gcctttcata tgaacaagct 3130201 aagctggaga ggcgatgttc gcggaacgga tgaaaacaga aatgccggca gcccgcaaaa 3130261 acaggaccta aagatatgga aacaggagat ttccgcctcc tccaaaggga ctaatttaca 3130321 attttaatga aaaatataca aaatgacact tctatccttt atttcaattt tagataatag 3130381 atatgatctg ataaaaggag ggcaagtgat gacaaaaaaa gcatggtttc tgccgctcgt 3130441 ctgtgtatta ctgatttccg gatggcttgc gccagcagct tcagcaagcg cgcaaaccac 3130501 attaagcctt aatgaccgat tggcgtcttc cccttcagga acgggaagcc ttctctcatt 3130561 agccgccccc gctgcaccct atgctgacac agatacctat tatgaagggg ctgaaggtaa 3130621 aacaggagac tcgctaaaaa gcaccctgca ccgtattatc agcggacaca cgatgctgtc 3130681 ctacagcgaa gtgtggaacg cgctgaaaga aacggatgaa gacccaagaa atccgaataa 3130741 cgtcatcctg ctctatacga atgaatcgcg ttccaaaaac ctgaacggcg gcaatgtcgg 3130801 cgattggaac cgcgagcatg tctgggcgaa atcccatggc gattttggta cgagcaaggg 3130861 acctggtact gatattcatc atttgcgccc ggctgatgtt caagttaaca gcgccagagg 3130921 aaatatggat tttgacaatg gcggcactga atatgcgaag gcacccggaa attattatga 3130981 cggcgattca tgggagcccc gcgatgatgt gaaaggcgat gttgcccgca tgctgtttta 3131041 catggctgtc cgttacgagg gtgatgacgg ctatcctgat cttgagctta atgataagac 3131101 aggcaacggc tcagctcctt atcatggcaa acaatctgtc ctgctcgaat ggaataagca 3131161 ggatccggtt gacgaccgcg agcggaaaag aaatgaaatc atttatgaaa aatatcagca 3131221 caaccgcaat ccatttatcg accaccctga atgggcggat gagatttggc cgtaagaaaa 3131281 aggtgctcct tttgaggagc acctttttct aatacacagc ctcttccgtt tccgcatcga 3131341 aaaagacgac gtggtccatt ttcactgaga gctggattga atcgcctgca tcgattcgcg 3131401 tgtttccgtc caggcggacc ttgagccgct cgtccccagc catgacatgc actatgagct 3131461 ccgagcccag attttcattc acttccacgt tcgcttgaaa cactgaatca aacaactggt 3131521 catttcctgt catttgtgtg atgtgctccg gccgtacacc ggcaatcatc tgttctccgg 3131581 catatccctt ttccttcagc cgctttgctt tttcttcagg aatatgaagc cggatcgaag 3131641 aatttgtgaa aaacagctcg ccatgctgct gttctatgat gcctttcaaa aagttcattc 3131701 cgggagagcc aatgaagcct gcgacaaaca aattggccgg gtaatgataa atgtcatgag 3131761 gtttcgccac ttgctgaatt tccccttcat tcatgacgac aatccgatct cccattgtca 3131821 ttgcttcggt ctggtcatgc gtgacataaa tgatcgttgc ctctaatcgc tggtgcagct 3131881 tgctgatttc tgtccgcatc gtcactctta gttttgcatc cagattagaa agcggctcgt 3131941 ccattaaaaa gaccttcggc tccctcacaa tcgacctgcc aagcgccacc ctttgccgct 3132001 gcccgccgga gagcgccttc ggttttctct tcagcaaatg ttcaatttct aaaattctgg 3132061 ctgccgcatg aacccgctcg gcaatttcct gtttcgccat ctttctgagc tttaatccaa 3132121 acgccatatt atcaaaaacc gtcatatgcg gataaagcgc atagttctgg aataccatcg 3132181 caatatcacg ttctttcggc ggaagatcat tgacccgctc cccatcaata agaagatttc 3132241 cttcagaaat gctttctaat ccagccacca tccgcagcgt tgttgatttt ccgcatcctg 3132301 acggccccac cagcaccaaa agctccttat cctttacatc taaatcaaag tccttcacgg 3132361 ttaattgtga gtgatatgat tttttgacgt gttcaaatgt taatgaagcc atcagaaaag 3132421 tccccctatc ttttgacccg ttatttcgtc actggaaaca acttggtctt tctgttattt 3132481 ttagagtaat cgattcccat ttttgctata tttctaaaat aaaaaatgta aatttgtatt 3132541 ataacgtcat aatacattat aatataaata ataggttaaa aggaggctac cctttgttaa 3132601 acaacggaag ttctacacct ttatacattc agctaaaaca aatcatcact gatgacatca 3132661 aaaagggcgt gtattcccca accgccaagc tgcctaccga aaacgagctt tgcaccaagt 3132721 ataacgtcag ccgcatcacc gtcaggaaag ccattctcga tttagtcgaa gaaggctatc 3132781 tgatcaggca gcagggaaag ggaacgttcg ttaaaagccc taaattaaaa cgagagctga 3132841 tcgctgtaaa cggctactcg gaatttatgg aatcaaccgg caaaaaaccg aagcatcatg 3132901 tgctgtccca tgacatcatt ccagcgtcaa aacccatcgc cgaaaagctt caaatccaac 3132961 ccgagagccc tgtggttgaa ttaaaacgga ttttatataa tgatgatcag cctctcacct 3133021 ttgaagtgac gcattatccg cttgatttgt ttcccggcat tgataccttt attgctgacg 3133081 gcgtctccat gcatgatatt ttgaaacagc aatacaaagt tgtacccacg cacaatacga 3133141 agctattaaa cgttgtatat gcccaacagg aggaaagcaa atacctggat tgtgatatcg 3133201 gggatgcgct gtttgaaatt gataaaacgg cttttacatc aaacgaccag ccaatctatt 3133261 gctcattgtt tttgatgcac acaaaccgtg tcacttttac catcaacagc ccctacacat 3133321 aacaggcata aaaaacgaga cactgcttat agtattctcg ttttttcact gcttcccccg 3133381 tcctccaagc gataaggata gccatagccg aaagctccgt acacaccgca agttttcgca 3133441 gccgtttcag cagcctggcg caaagcatac gttatatcct gcttcacgca aaaggcagtc 3133501 aaaaagcctg ctataaaaga atctcccgct ccaagtgtat ctattatatc agcttccaca 3133561 atcggctgat gatagactcg atcacccgca gacaggattg ctccttggcc ccctcgggtc 3133621 atacaaacca ttttggctcc gtacccatga gctgttttgg caagctcacc gcattccgac 3133681 tcactcaaat cgcttcctga aaaaaacgca tacgtcacat aaggacagac cctcctcaaa 3133741 taatcatcct cccgattggt tgaaaaatca aatgagaccg ggaccagccc gcacagctgc 3133801 ggaagatcgt tctcaagcct gctgtacacg ctcgtatgca gcagatcatg cccgctgata 3133861 aaagatacat ctttctcctg aaacgcgagg cgaagccggg actgaatgcc gcctttattt 3133921 gatctgacaa aaatgcggtc cccctgttca tcaagggtga caatcgccat cccgttttct 3133981 ccgtgcgcct ggcggatata atctgcattg acctgctcca gcttgagaac gttcaacaga 3134041 tgcgccgcgg cttcgtcatt gccgacgatt ccgatatagg aagactcatg cccgagccgc 3134101 ttggcaagca cagcaacgtt taaggcattt cctcccgggt aaaatgtttc ttgatcctgg 3134161 tagtaatcta caacattatc tccaaccgca atcaatttca tagcgcttcc tcctttatcc 3134221 ttttacactg ccgcttgcaa tcccgcggac aaaatatttc tgcatcaata aaaatagaat 3134281 aataatcggc gcggctgaaa tcgttaaccc cgccagcagg acgccccagt ctgtctgcag 3134341 cgcgtctctg aactgcatca gcccggctgg aatggtccgt aaattctcat catctatgaa 3134401 aataatcgca aacataaact cattccatgt atggtaagcc gtcaaaatgc cggatgtcac 3134461 caaaatcggc acgctcattg gtaagaaaat tctgaaaaat actccaaaac ttgtacaccc 3134521 atccaaatag gccgcctcct ccaattcttt tgaaatagaa agaaaataag agcggatcaa 3134581 aatgatggtg aatgggatcc gataagccgc atacggcaag attaacgccc aatacgtatt 3134641 gtacaggccc agcgactgaa taatagaata aagcggcaca agactgacct gcggcgtcag 3134701 catcaatccg ccaagacata gcaccaaaaa gaatcctttt cctttaaact caaaccggga 3134761 aaggccatac gctgcccatg cactgataaa gacagtgatc acacacgtca gcgccgtaac 3134821 gatgacactg ttcataaaat aagaagaaat cccctgattc caggcggaaa caaaattttc 3134881 cggatgccac gaagacggca gcgaccagct gtgctcaaaa atatcgtcag agtttttaaa 3134941 ggcgctcatc accatccaga gaagcggata ggcaatcgca atcagataaa gaaacagaaa 3135001 aacccacaca gacgtttctc cgatatacca ttttcgtcta ggcttatctt tcacctcaat 3135061 gtgctggtca ggcaccggct ccaatctgaa cgaatctgtc ttcttctgag gcagcatcag 3135121 ttactcctcc tttccggttt taaagaactt catttgcatg agcgataatg caagcgtaat 3135181 gattaacacg acagtggcaa tcgctgaggc gtagcccatc atatcctttg taaaggcgct 3135241 tttatataaa aacgtgctca agacttctga cgcttttccc ggcccgccgc ctgtcaaaat 3135301 gtacggctca ttaaagaccg taaaggctcc ggtcagcgtc atgaccaccg caacaaaaga 3135361 catctctttc gtctggggaa cagtaatatg aaaaaactgc tgaattttac ccgcgccgtc 3135421 aagccgggcc gcttcataca gttcatccgg tattttttga atcgacacga tgtacagcat 3135481 cgcaatataa ccgacagatt gccactggga cacaaaaatg acagaaagca tagctgtgct 3135541 gtcatccccg agccaggccc tcgtcagctg atcaagaccg atggcctgaa gcagctgatt 3135601 caaaagccct gtctccggat tgtaaataaa atcaaacaaa agcgcgatca ccgtcattga 3135661 gatgacaacc ggcaaaaaga aaacggtacg aaaaaacggc gaccattttc tgaccagctt 3135721 atcctcaagc accgccgcca aaatcaaacc gccaaatacc tggcatacaa ttgagatcac 3135781 tgcataaagc acattattgg taagtgcctg atagaagaca ggatcatgaa ataattcaac 3135841 atagtttttt aagccgataa acgttttttc cggagaaaat gagctccact gaaacaggct 3135901 gaggaataca ttctcaaaaa tcgggatata aacgaaaagt aaaaaaacga gagcgggcac 3135961 caaaaacaaa taggggatta ttttattctg attgaccaag ggtatctcat ctcctttata 3136021 aaaagaaaag gtgcgaagct tcaccttttc tttgatttat tcagctgacg ccctcacctg 3136081 ctttgctgcc ttttgaacgg ctttcatcac ctgctgcggt gtcatgtcgc cgccaagcat 3136141 ttgctggacg cccgttaggt acgcatctgc gacttcaaca tcgacatcca tatcaaacca 3136201 tggaaccatt gatttggcat caacaatatg ctgaacggct tcacgctgaa tggctgttgc 3136261 attttcttca gtagccgtac cttgcactgc actgtatttc ccgacatctt tcacgagctt 3136321 ttcgcccatt cttttcgacg tcaagaactg caaaaattcc atcgcttcct tcggatgttt 3136381 tgttcttgag gagatcatga atccttccgg cgctcccgtt aacgcttctg aagatccttt 3136441 ctgcccgctg atttcaggaa atgggaacat cccgagatta accggttcaa ccagcttgat 3136501 ttccgctgtt tccgcatata tcatcgccga ctttccgctc ttaaattgct gtctcacata 3136561 ttcgtggtcg acggagttta catgtttatt aaagtaaggc atcagctctt gaagcttttc 3136621 aagtgctttt acgtagcctt catcagtaaa ttcacccgtt ttggcgttat agtccttttc 3136681 ccgtgttttt tcatcgacca tccgctgatt aagcgtgccg atatagtgcg agattgtcca 3136741 agtcgccttt gttccaaagc tgatcggtgt gtagccatgt tctttcagct tttttgacac 3136801 atcgattaat tcatcccacg tcttcggggg atcaagattc agcttttgga aaatgtcttt 3136861 attatagaag aatgatttag cgtccatttg ccacggtacg ccatattgct tgttttcata 3136921 agtaaatggt gtaatttgcg attgaacgag ctgtgatgac caatcggtgt catttttgta 3136981 gtaggacgag agatcaagtg ctttattgcc tctgataaat ttaaaagcaa actcatcgct 3137041 ccaagagaag taaatgtcag gagggctggt ggttcccagc atgaccttaa ttttatcttt 3137101 ataggagtca tttaaaacgg cttcaatttg aatgtcgata tctgggtgat ctttttcaaa 3137161 ttccttaaca acctcttcaa aataactttt ttccggctcc tttggccatc tgtggaaaaa 3137221 tttcaatgtc acctttccgt ccgctgaact gctttggctc gaacagcctg cgatggtgag 3137281 catactgaca gctgcaatga tcaagaacaa caacattttc ttcaaagggt tggcctcctc 3137341 tggacattag actataatgt tatataacat tatagtctaa tgcataatgg ttcttcattt 3137401 tcagatcaat actcaacttt ccacatgtat cttctatgag ataaaggatg atttctctcc 3137461 tctgccagct cgtctgcata gcttctcagc acacgattga gaacgagcgg agcaagatag 3137521 cctttaactg aatcgtcaat tgcagtgaag tcgtaagatg cagcatcaag cacagtgagc 3137581 tttttgccat actttttcga gaaggtaagc gcccgctctt caagaggtct tgtttcatct 3137641 aaaccgagca ggatgataaa cggcacggat tcatcaataa tttcaaacgg tccgtgaaaa 3137701 tattctccgg catgaatggc gtgggaatga atccattgca tttccatgag aatgcagatg 3137761 ctgtaggagt aagcgacacc gtagtttgca ccgcttgcca tggtataaat aatgctttct 3137821 ttttcatggg cttttgcaaa ttgcttggcg ttgtcagctt cctgcttaag ggctttttca 3137881 tatacagcct gcaattgatc taagccttca attgcttgct caaatttcgt attgttttct 3137941 aatacttgca gggttccaaa aacgatttga tacaaaacgc catagtttgt attgatcgca 3138001 agcgcctcat caccccaatc gtactgggca acatattgcg cttcctgcgc taaaggagac 3138061 tccggtttaa acgtcatcgc aatcgtaagt gcgcccttgc cccttgcaaa cgcagcagct 3138121 ttgactgtct ccggggtatt tcccgaatgc gagcacaaaa taacaagaga cttttcacca 3138181 agctgaacag ggttgcgctg aataaattcg ttggcgctgt agagatcgga gtttattgat 3138241 tttgactctc tgtcaaacac atacttactc ggatacataa tggcagaaga ccctccgcat 3138301 gcgacaaaga atacatgatc aatggttttc cctttcaaat cctgcaagaa agcttgaacc 3138361 tcacgattta cttttgctgt ggcctgactc aaatccttca ctcctcgttt ttattatata 3138421 acgttatata acattatata ttgttatatt aaagtccgcg ggtaggattg tcaatattat 3138481 tttctgaaat ttctcaataa tttattcgga tgacagacaa agggtctata tgcgaaaaaa 3138541 tgcccaaatc aaaagccaga acttgactta agctctggct tcgctgttca atccgcagac 3138601 tgacgtctta tttaaaaaat accttgtcta tattgtactt cgagtgctgt gtattgatga 3138661 tatatgtttc gtaaatctct ctttccattg gatcatcaac tacacatacc tcaattttat 3138721 aaacttcatc tctgtgatgt ttgatcggtg aaacagtgtc ttcgaaatgc ttcttaattc 3138781 tctgtcttaa ctttctggct ttaccgacaa acagcagctc gtcatgaatg ttgtaaaaca 3138841 taaaaatgcc gcctttgtcc cttgggatct ggtgaaagtc gatgaatccg tgaatcggtt 3138901 ttatcttcgg ctcgttatca ttagctgact gctgtcgttc agtgatggtg acattcggtg 3138961 cgggtatatc aatttttatc aaaatcagtt cacgtcctct ttttcattaa agataaatgc 3139021 taacacatac agaaaagaaa agctagaaca gctttattat atttgtttgt catgctctta 3139081 cttattatgc aagtgctccg gctggatcat aaggactaag gtctaattct gtctgctttc 3139141 cgagaactag ctttgcgagc tctgcaccca aaaacggccc catcgtcagt ccagaagcac 3139201 ccaaaccgtt tgcagcgtac aggccttgaa cattcggcac ggcccctacg accggcagaa 3139261 atcccggtgt aaacggcctg aagcccactc ttgtttcaac agcagccgca tcagcaagac 3139321 ccggtgcaac ggctaacgct ttgctcaata cttcgtgctg gcctccggct gtcacacgaa 3139381 gatcatcaag accggcatcg ttttcgtgtg tggcgccggc tacaattctg ccgttatcaa 3139441 acgacagaat gtactgatca ctcggcggca ttacaaccgg ccacgatcct gtatctgcat 3139501 ctgtcatttc aaaatgcata atctgcgctt tttgaaatga cacttgaaaa tgaatgccaa 3139561 gaggcttcaa tatctcattg gcccatgctc ccgccgtcac aatgaccgcg tcagccgcaa 3139621 actgctttgt atctgtttgc acgccggtga ctgttccgtt ttcaaaaagc aaggacgcat 3139681 ttcctttgat gaccgttgcg ccgcgtttct ctgcagcgct taaaagcgac cggcacagcg 3139741 ctcttccgtt cacacgggcg gcaccgctga tatgaaccga ttcatagccg tcagctaaaa 3139801 tcggaaacag ctttttcgtt tcacttgcag acaagcgggt aatgtcgccg atttccggcg 3139861 catcctcccg tctcttatac gccctttcct ccattttatc gagtttagac gcgtcagtat 3139921 gaatgctgat ggcaccgaca cgtttgtatc ctgtatccga ttcaccgtct ttttccaatt 3139981 gatggattaa atccttatag taccgcgctc cccccttagc aagctggtac caatcctgat 3140041 tacggcgctg cgagagccaa ggacagacga tccccgccgc cgcatcagtc gcttgtcccg 3140101 gctctttccg atcaatgaca gtaacgcgag cgcctgtttt tgcgagatga taagccgtcg 3140161 acgcgcccag aatccctgcg ccgacgatga tgtacgattt catatgcaaa caccttttct 3140221 attataatgt ctattcattt taccaaatca aatgctttcc ttcgaccttt tgccctaatg 3140281 tggaaaaacc gcgaagttcg tccaatctct ttactctcct atcgaatatc ctgtcactat 3140341 caatagagaa aggatgatac catgagcgaa aatcgtcatg aaaatgaaga aaacagacgc 3140401 gatgcggcag tggcaaaagt ccaaaacagc ggtaatgcaa aagtcgtggt cagcgtgaac 3140461 acagatcagg atcaggcaca ggcgcagtca caagacggag aagactaatg aacgaaaaca 3140521 tcattcctct taacagacat actcaagaga tacccactac tgaatctgtt atcaaaaaca 3140581 gcggcaactc agaggtccat atcgacattc acattgatac aatgccaatt gcttttgcta 3140641 tattatgctc tgcattagcc gcaaagcaga tgacaaaaga ggaattcgat atggcttata 3140701 ctcaattgcg agagatgaac agagaaaata acagcagatc atctgtaaag caaattatca 3140761 atcaagagac agaagaagag taaaaaaccg cggcccctcg gccagcggtt tttcttctgc 3140821 atacaaaaag gacgcgactg aatcggttac ttctgtacaa tttgaataag gttaccgcat 3140881 gtatcgtcga agacagctat tgtgacttcg cccatttttg tcggttccgt cgtaaacgtc 3140941 acgccttttt cctttaatcg gttgtactct ttttgaatat ctgcaacgcc aaacattgtg 3141001 gccgggaggc cttcggagaa tatcttcttt tgatactcct tggcggcagg atgttcattc 3141061 ggttcgagta aaagctcggt tccgtcttga tcatctggag aaacaagcgt tatccacctg 3141121 aatttcccca tgggaacgtc ttcctttttt ataaacccaa gtttttctgt ataaaactcc 3141181 agtgccatgt cttgatcttg tacaaatata ctggtaacaa cgattttcat actgtttttc 3141241 cctccttcga tatgaatgaa gcatggtact atgctaacaa tctggctaca agcaaaacaa 3141301 cccacacatt tatcagaggc cctgttctga ttttataaaa ttattctatc catcctttca 3141361 gcaaattttt aagcggttcg ttgttgaata taagtactcg atattttccc tttcgttttg 3141421 atgttacgag tcctgcatcc tccagtacag aaaggtgttt agctatcgcc tgtcgcgtaa 3141481 tagaaaggtc gtactttgta ataagacgta tcgtaagttc atacaacgtc agctcgttgc 3141541 gttcagataa ttcgtctaat ataagccgcc gagtcgaatc gccgagtgct ttgaatatag 3141601 cgtctttgtt cccattcata tattgagtat aagcaaccca ttagttgcat gtcaagtata 3141661 agcaactgta tggttgcgtg atatagaaac tgaacctatc cggcgcaggt ctgaaatatt 3141721 ctaatcgata aggaattaaa accattaaaa taacagtgga tatgtctctg aaaaataaaa 3141781 gaagacgaac ttcaaaagtt cgtcttctac aatcaaattc ggcacgccgg ccattttaaa 3141841 gttgataact atctctaaac cccttgataa acaaaggagt tttcatcatt aaccgataga 3141901 accttccatt tcgaacttaa tcaaacggtt catttcaact gcgtattcca tcggaagctc 3141961 ttttgtgaat ggctcgataa agcccattac gatcatttca gttgcttctt cttcagaaat 3142021 accgcggctc atcaagtaga agagctgctc ttcagatact ttagacactt tcgcttcgtg 3142081 ctccaatgaa atgttatcat ttaagatttc attgtaagga attgtgtcag aagttgattt 3142141 gttatccata atgagcgtat cacactcgat gttagagcgg gcgccttccg ctttgcgtcc 3142201 gaagtggacg attccgcggt acgttacttt tccgccctgt tttgaaatcg attttgatac 3142261 gattgtagat gatgtgtttg gtgcaaggtg aatcattttc gcacctgcat cctgatgctg 3142321 gcctttaccc gcaagagcga tagaaagcgt cataccgcgc gcgccttcgc cttttaggat 3142381 acaagccgga tatttcattg tcagcttaga accgatgttg ccgtcgatcc attccattgt 3142441 tgcgttttct tcacagactg tacgctttgt tacaaggttg taaacgttgt tcgcccagtt 3142501 ttggatcgtt gtataacggc agtagccgcc ttttttcacg atgatctcaa cgaccgcact 3142561 gtgaagtgag tttgttgtgt aaacaggcgc agtacagcct tcaacataat gaacgcttgc 3142621 ttcttcgtca acaatgatca gtgtacgttc gaactgaccc atgttctcag agttgatacg 3142681 gaagtaagct tgtagcggtg tttcaacctt cacgccttta ggcacgtaga tgaaagaacc 3142741 gccggaccaa acagctgagt taagcgccgc aaacttgtta tcagtcggcg ggattacttt 3142801 tgcccagtgc tcacggaaaa tatcttcatt ctctttcagc gcgctgtcag tgtctttaaa 3142861 gacgatgcct tgtgcttcaa gatcttcttt catgttgtgg tatacaacct cagattcgta 3142921 ctgagcagaa acacccgcaa ggtatttttg ttcagcttca ggaataccga gcttgtcgaa 3142981 tgtttgttta atttcttcag gaacttcatc ccaagaacgc tctgaacgct cagacggttt 3143041 tacgtagtac gtaatttcgt caaagttcag tgagtttaaa tctccgcccc attgaggcat 3143101 cggcatattg tagaaatgct caagtgattt caagcggaag tcaagcatcc attgaggctc 3143161 ttctttcatg cgagaaattt cttctacgat ttcttttgtc aatccgcgct ctgaacggaa 3143221 aatggaaacg tccttgtcgt gaaaaccata cttgtattca ccaatatcag gcattttttt 3143281 agccatccat tttcactcca atccttttaa ttgccgcctt cttctttcgc gactcctttt 3143341 tcaagtgctt tccatgacag ggttgcacat ttgatacggg cagggaattt tgaaacgcct 3143401 tgaagggctt caatatcccc gagatctata gaatcatcat actctttccc ttgcatcata 3143461 tccgagaaaa tcttagacat ggaaagggca gtttcaatat ctttcccttt aatcgcctga 3143521 gtcatcatcg aagcggatgc cattgaaatg gaacagcctt ccccttcaaa cttcgcatct 3143581 tccacgatgt ctccgtcaag cttcattgtc agtctgatgc ggtcgccgca tgtcggattg 3143641 ttcatatcca cgacaatgct gtcatttaaa acccctttat ttcgcgggtt tttgtaatga 3143701 tccataatca cctgtctgta caatgtatct aagtttgcat taaaagacat ttgtaaaata 3143761 ctcctttgtc ttttgaagag cttccacaag cttatcaatc tcttcctctg tattatacag 3143821 ataaaagctt gctcttgcag tagcagttac atccagccat ttcatcagcg gctgcgcaca 3143881 atggtggccg gctctgactg cgattccctc cgcatcaagc acagtcgcca catcgtgcgg 3143941 atgaacatca tcaaggttaa atgtgacaag cccggcacgc tcttccggcc cgtaaaccgt 3144001 tacgccgtca agctggcgga agcgttcaag cgcataagct gcaagcttgt gctcatggcg 3144061 ggaaatctca tcaagaccga tttcttcgag aaaatcaatg gcggcaccga ggccgattgc 3144121 tcctgcaata atcggcgtac ccgcttcgaa tttccacgga agctctttcc aagttgattc 3144181 ataaagcccg acaaagtcga tcatttcacc gccgaattcg gcaggctcca tgttttccag 3144241 cagggctttc tttccgtaca gcacaccaac accggtaggt ccgcacattt tatgggaaga 3144301 aagcgcaaag aagtcgcaat cgagatcctg cacgtcaatt ttcatgtgag gcgtgctttg 3144361 tgcaccgtcc accacaatga cagccccatt gtcatgagcg attttcgcca tttctttaat 3144421 cgggttgacc gtgccgagaa cattagatac atgagacacc gcaacaattt ttgtgttgct 3144481 tgtgaccgtt tctctgacgt cttctaaaga aatcgttccg tcttcctgca acggaatata 3144541 ttttaatgtg gcgccagttg cttttacagc ctgctgccac ggaatgatat tcgcatgatg 3144601 ctccatgtag gtgatgacca cttcatcacc aggtttcagg ttggcgcgcg catagcttaa 3144661 cgccaccata ttcagtgatg tggtcgtgcc ttttgtgaaa ataatctcag ccattgactt 3144721 cgcgttaata aacttgcgga ctttttcacg cgctccttca taaccatctg tcgctctggt 3144781 tccaagtgta tggacgcccc ggtgaacatt ggaattgtat tggttataat acttatccag 3144841 tgtttcaatg acagcacgcg gcttctggga agtcgccgcg ctgtcgagat aaacgagatc 3144901 atgtccgttc acttgctgat gaaggatcgg gaactgttca cgaatatctg tgatattcat 3144961 tacttcactt tcctttcgat aacagaaact aattgtttct taacgccttc aatcggaagt 3145021 tcatttacta ccggtgcaag gaatccgtaa atgactaagc gttctgcttc ttctttcgga 3145081 attccgcggc tcatcaggta gtaaagctga atagggtcca cacggccgac agatgccgca 3145141 tgtcctgcag ttacatcgtc ttcgtcaatt aaaagaatag ggtttgcgtc tccgcgtgct 3145201 ttttcgctaa gcatcagcac gcgtgattct tgctccgcat tcgctttaga agcgccatgt 3145261 tcgattttgc cgattccgtt aaagatagaa gaagcggaat ccttcatcac accgtgcttc 3145321 aagatatagc cttcagaagc tttaccgaaa tggatgattt gtgttgtgaa gttttctgtt 3145381 tgctctcctc ttccgacaac aaccgttttc gtatcgccgt atgtgccgtc accgtaaagg 3145441 tttgttgtgt tttcggaaat cgtgtcgcca tcgttcatca ggccgagagc ccactcgatt 3145501 ttgctgtcgc gtccgcgcgc agcaccgcgg cggttcacat aagttgtcac accgcttgac 3145561 agattatcca ccgcaccgta tgtcacgctg gcattatcac ctgtgatgac ctcactgata 3145621 atattgaaga cagcgtcttt cgggtttaca gtgctgatgt agttttctac atatgttaca 3145681 gagctgtggt cttcagccac aatcagcacg tggttgaata gagctgtatc attgctttcg 3145741 tggacataaa cagcctgaac cggcgtctcc acctgaacat ttttcggaac ataaaggaat 3145801 gctcctccgt taacaagagc cgcgtgaagt gcagttaact tatgttcgtc aaccttcacg 3145861 ccgtccttca taaagtattt ctccaccaag tcgctgtgct cgcgtgcagc agtcagaata 3145921 tcagtgaaga tgacgccttt gtctttcaat tcttgagaaa gagaaagatg tgccggcgtc 3145981 tggtcacgct gtacgtataa tgttttatct tcgttttcaa tgtcgatcag cgcttttact 3146041 tcatcagtca aatcttctaa tgaagaaagc ggttcgttat ccactgtatg cttcgcgaaa 3146101 ttcgtgaagt tccagtttgt gatttttgtt ttgtcaggtt tcggcatcgg cagatcctca 3146161 gcttgttcaa gagcctgtaa gcgcaggttc ttcagccagg caggttcttg gtgcttttcg 3146221 gaaaagcttt tgagatactc ctgatctacg gatagttttg tacctagtgt catattaatc 3146281 cccctaacgc ttacgcttct tggccaacag tttcgtcttc aatgccaagt tcttgtttga 3146341 tccagtcata accttctgct tcaagacgct gtgcaagctc tgcaccgccg gattttacaa 3146401 cgcggccttg catcataacg tgaacaacat ccggagtgat gtagtttaac aggcgctgat 3146461 agtgagtgat catcaggcag ccgaagtttt cgctgcgcat tttgttgatc ccttttgata 3146521 caactttcaa agcgtcaata tcaaggcctg agtcaatttc atcaaggatg gcgattttcg 3146581 gttcaatcat cattaattga aggatttcgt tgcgtttttt ctccccgcct gagaagcctt 3146641 cgttaagata gcgctgagcc atttcagggt ccatttcaag gaactccatg ttttcgtcca 3146701 ttttgcggat gaatttcatg agagaaattt catcgccttc ttctctgcgc gcgttgattg 3146761 ctgagcgaag gaagtcggca tttgtcacac cgctgatttc acttgggtac tgcattgcaa 3146821 ggaataagcc tgcctgcgca cgctcgtcca cttccatctc cagtacatct ttgccgtcaa 3146881 gcgtgatgct gccttttgtt acttcatatt taggatgccc cataatagca gctgataaag 3146941 tggatttacc agttccgttc gggcccatta ctgcgtggaa ttctccacct tttatttcaa 3147001 ggtttacacc ctttaagatc tctttccctt cgatttcaac gtgaagatct ttgatcgtta 3147061 atgttgaagc agccatatct atacctccaa aaatatataa tcattattct cattttattc 3147121 tcattctaat tttataacaa atgaaaagta aatacaactt tttatcgtgc cttgcacatt 3147181 cctcaagttt aacaaagatc agcactttat taaagcgatt gaaaaagaaa aagagtggat 3147241 tcccaccctt ttttaaaaga ttgattttct caataagctc ccgcagaaat ccgcttgctt 3147301 ttttcataat caagctctct ctgccgctct actttcattc ttgtttccag ccggcgtcca 3147361 tattcctcgt atccaattcc gtgtgacagc tgcatcgctt tttccatttc tgacgtataa 3147421 tcgaggttca gtctgtcctg gctgctgcaa ataatgaatc aatcccttca tatatttgct 3147481 ttttattgta ccagtgctgc gttggatgcc gcaaaaacga tttggcgtga aatagcggca 3147541 gatgagacga aagcatcctt tcagaacaaa tgagaatggt ttttcggaat attccttctc 3147601 ttaatgcgtg gtgtttccga attcctcaat gcactgttga acgactgtca cgccttggct 3147661 gaaagctgcg ccgcctccaa atgccgctgc cacactgacg gcttcgagaa tgttttcttc 3147721 tgacgctccc tgatcaagac agccttttgt atgatagatc atgcaatatt cgtcctgagc 3147781 attgatggca attccgaggg cgatcagctg tttttctctt tcagtcagag aattcccggc 3147841 aaagcactgt tcagtaaatt cgttaaattt tcttcccatc agcggcatct tttgttcaaa 3147901 tgtgcctaaa ccatgtttat attgttttaa cgcgtcctgc atgcttcctc tgtcttgatt 3147961 caaagaaaat ccctccatct gtttaacatt cctttttatt atgaacagct tttaggaaaa 3148021 tacgcgaaaa aaaccccgga attctcatcc ggggtttcag tcttattcag atacaggaag 3148081 cacagctccg tcgtattttt tctcgatgaa gtctttgatc tttttagagt gaagaacttc 3148141 catcagcgct ttgatttttg cagaatcttc ttcgcctttt cttactgcga tgatgttagc 3148201 gtatgggttg tttttcgttg attctacttc aattgcgtct tttttaggat ttaatttatt 3148261 ttggatcgca tagtttacat tgatgaagac cgcgtctcct tctttgtttt catatgcttt 3148321 tgccgttaat tcaggcgcta cttttttgaa ttcaaggttt ttcgggtttt tcttaatgtc 3148381 tttcaatgtt gcgtcaactg tttccacttt agaatcaaga gtgattaatc cagcgttttc 3148441 aagcattgca agcatacggc cttgttcagc aacgttgttt gtcagaatga ttgtcgcacc 3148501 gtctggaagg tctttcagtg atttgtatgt tttagagtaa ataccgaatg gctctaagtg 3148561 aacagcgccg gcattcacaa gtttgtaatc tgtgttttct ttcatttctt gctcaaggta 3148621 aggaatgtgc tggaagtagt tcgcgtccac ttctttatca gctaaagctt tattgtacat 3148681 tttgtaatca ctaagcactt tcactttcag cgtatagcct ttttctttca gcaatggttc 3148741 agcttctttt aaaatttccg catgcggtgt ttttgttgcc gcaacgacaa tttctttctt 3148801 gccggattca gcgccgttat tcgaaccgca ggcagccata actcctgcaa atacaagcag 3148861 taatgcaccc aaaaatagct ttttcaatgt aaatcctccc ttatcgtttg tctataatat 3148921 ttgttattag atcaccgatg atttgaataa taaacacgat gattaaaata aacacagtag 3148981 caacgaaggt aacatcagcg ttattagact gatatccttc tacgtacgca aggtttccaa 3149041 ggcctcctga accaatggct ccggcaattg ccgttgaacc gattaaagcg atggctgtaa 3149101 ccgtaatgcc agaaataaga gcaggcattg attccggaat cagcactttg aaaataatcg 3149161 tagacgtttt cgcgcccatt gatttagctg cttcaatcac acctttatcc acctcacgca 3149221 gcgcgatttc aacaaggcgc gcgtaaaatg gtgccgagcc gattaccagc gccggcaatg 3149281 cggcgtttgg ccctaagatc gtgccgacta aaaatttcgt aaaacctaat agtaaaataa 3149341 ttaaaataag gaacggaatc gatctgaata tgttaacaac ggctgcaatc actgagttga 3149401 ccgctttatt ctgccagagg cttcctttgc tcgtcagaaa gagcagcaag ccgaggatga 3149461 ccccgatgac aaaagcaaac agtaaagaaa tcagcgtcat ataaagtgtt tcatatgtcg 3149521 cgttccataa ttcagttaaa tcaacgttcg ggaagtattt ttcaaacatt cgtgatcacc 3149581 tctgctttca cctgtttgtc attaatgaat cggatcacgt tttgcacttc ttcctcgtcc 3149641 ccgtcaatgt ggatgaacag tgaaccgtaa gccccatcct tcgtctgcga aattttccct 3149701 tgcagaatat tgacgctgac attgaagttt ctgatcatct ctgtaatcag aggctgttca 3149761 gctgactcac cgacaaatgt gagctgaacc atttttcctg atgctgtatc atcaagaagg 3149821 tgctgaagcg tctctttcgt ttcttccggc tctgtcacct gttgaacaaa tcgttttgtc 3149881 atttgttcct ttggattttt gaagacatcg agaacctcgc cttcttcgac caccttgccg 3149941 ttttccatga cggcgactct gttgcagatt ttgcgtatga catgcatttc gtgcgtaatc 3150001 agcacaatcg tcaaaccgag tctttcatta atatcggaca atagatccag aattgaatct 3150061 gtcgtttgcg gatctaatgc tgatgtcgct tcgtcacaaa gaagaacctt cggattgttt 3150121 gcaagcgctc tggcaattcc gacacgctgc ttctgaccgc cgctcagctg ggacggataa 3150181 gatttttctt ttccttctaa acctaccagt ttaatcagtt cattggcgcg cttgatccgc 3150241 tcgctctttt tcaccccggc aatttctaaa ggaaacatga tattatctct gacagtccgc 3150301 gaccaaagca aattgaaatg ctggaaaatc atactgatct catggcgtgc ttttcttaaa 3150361 ccgcgtccat ttacttcatt aatcttggtt cccgccactt ccacggttcc tgaggttggt 3150421 ttctcaaggc cgttcagcag acggattaag gaactcttac cagctccgct atatcctata 3150481 attccaaaaa tctcaccttt tttaatggaa agcgagacgt tttggacagc attgacatct 3150541 ccatgtttcg acttgtaaac ttttgaaaca tcctgaagat tgatcaaagc aatcacctgc 3150601 cttaacacta ttctaagaaa tcttccggtt ttttctgcaa aagaaaagcc tttctgcaca 3150661 cttgagcaga aaggcttata taaaatgcct ttctctcatc tttcaaagct gaacgcttcg 3150721 tgtgaattgg caccatttca acagtgttga tggttgccgg gcttcatagg gcacttccct 3150781 ccacctctct tgataagaga aatatatagt ctttttcgtc cggaaattct taatgtagaa 3150841 tagcacggcg aatgattaaa tgtcaataaa ataaatgatg tcaactttta ctattataat 3150901 aatttattat tttttaattt tttaaaatcc tctgaaaaaa tccatttgtc agccagagaa 3150961 tggcttccag ctttaacagg gccctgaatg acccctttac tttgaggctt ccgctctgaa 3151021 taaggtgctg aagggaaatg tctccgtgca ataaatcaat aatttccgtt tggtttccgt 3151081 aaaaggtcag gttggacgtt tggggcggag aaactttttt catttctccc tgttcgttta 3151141 ttgagacggt taaggcttct gcttctcctt ggaaggtaat gagcaatgtt gaggcattca 3151201 aaaggggttt taaaaacaga tgctgatact catcttctaa aacttccgct ttctccatat 3151261 gtacaacctc ctatttgttg gtcatacata cacatttctc tctttgtcgc aagaacccct 3151321 ttataaaacg aacgacaatt tcattggata tgctgagaaa tatgtcataa atgggatgcg 3151381 gaagatgatt tttgtttgat cagctcatat aaataagaaa cggaatgaaa tgcatatcct 3151441 ctttcgacca tctttccgcc tttaaacagc agaaaacaag ggacgctttc aatttgatac 3151501 gcttttgcga atgtcggaga gtaattgaca ttgttttgat agaaggcgac atccggcagc 3151561 atttctttca ccactgtcag cattttgctt gcaagctggc aggtgccgca aaacggagta 3151621 tataaatata gaaggtacac atcatcttca atgtgatcaa gttcgtgttc ttggagttct 3151681 ttcatgctat acacctcggg actttctttc aagaaaaata gtatggacat tcagattcgc 3151741 acgcagcaat acagaagcga tatggtgcct gggcgcagcc gctacttcct tataggctct 3151801 gtcgacatgg agatggcagg cttcattaaa ttcacgcttc agctgttttc tcaatttctc 3151861 acctgattca tcagcatcaa ctaatatata gacgtcttta tcataaagct cgtcagccaa 3151921 ttcctcgagc ctcagctggc tgattgttcc gtttgtgcag ataatgcgca tcggttcatt 3151981 caggacgctt tcgattttct ctttatctga tttcccctcg acaatcataa ccttttccag 3152041 ctcatccatc ttcatcttgt tcacctgccg cgtcaaattt gaaatgttca gattgtaaaa 3152101 gaaggcagtg aaattcaccg ccaacattaa caccagccgt tttcgtagtc acaatctaca 3152161 tattttgcgt cgtctccaga gaccacatcg gctgtcttat aaaatttctc attttcaaag 3152221 gaataaccgg acttaagctc atattcattc atgcttgtca tttggccgat catctcatta 3152281 tcatgatata acgagagccg gccattttga aagcggcctg tcacgtcatt ggtgacatcg 3152341 agcttttgtt tgtcgaaagc catattggac acctcccata acgttagcgt gtccaattgc 3152401 ttttacggct atcctgtttt agtcttcttg tgtcatctct tcgtattgct ctgctgtcat 3152461 cagtttttca atttcagaag cgtcagatgg ctcaacgacg atcatccatg ctttttcgta 3152521 cggagattcg ttgacgaatt ccggactgtc atcaagatct tcgtttactt ccacaaccgt 3152581 tccgttaatc ggtgcataaa gctcagatac cgttttaacg gattcaacac tgccgaatgg 3152641 ctcgtccgct ttgatttcag cgcccacttc aggaagttcg acaaacacga tgtcgcctag 3152701 ttcggactgg gcaaaatgcg taattccgat tctggctttt tctccttcaa cttttaccca 3152761 ctcgtgttct cctgagtaac gcaaatcttt tggtatgctc aattgaatcc ctccattttt 3152821 tacagcacta caataagaag ataccacact tttcaaaaaa aatttacatt aagcccagtt 3152881 ttcttcaaat tggtcttctt taaatccgac agtcactttt tcgccgtctg ttgtaagcgg 3152941 gcgtttaatt agcataccat ctgaagccag cagttcgagc tgttcgtcct ctgacatatg 3153001 atacagcttt tccttgagat tgagctcgcg gtatttcatg ccgctcgtgt tgaaaaattt 3153061 cttgagatcc agcccgcttt tttcataaag cgcttttaat tcttctttgc ttggcggctg 3153121 ctcagcaata tgtatttcgt ttatttcttt cccatgctct tcaagccact tctttgcttt 3153181 gcggcacgtt ccgcatttag ggtaccagta aaaagttaac gacatcttct tccccctcaa 3153241 taaaataatc gaggttattt taacacagtt tgttttaaaa acctaaaaca gtgcttctta 3153301 aaaaagagct ccgcgcatgc ggagctcatg gccaatcaga cagtatattt ctcagcctca 3153361 aaaatgcctg ccgccgcctc gcgttttttc tgaatcacgt ttttaggcgt tacgcgtgtc 3153421 agcttgcgca gagcggaaag catcatgcgg agtgaatctc cttcttccat tgcgataagg 3153481 gattcctttg catgcgcttc gatttcgtta aaggcctctt gaacgaaaat ttctgtgtac 3153541 agcacctttt gcgctgcttt ttcagcgcct tgtgcggcaa tggccttttc cgttctgagc 3153601 acggctgatt ccattgcgta tacattgctg acgatatccg ctacgttcac gagaatttct 3153661 tgctcacgat cgatcgcttt tccgtatttt tgcgcggcta ggccggcagc aaacaacgca 3153721 atttttttgg cttgcttgac gatatatttc tcctgctcta agacgccgct tccaggctct 3153781 tcaggcataa gcatcatgag ttcttcctgc agcgactgcg ctttttcgaa taaaggcagc 3153841 tcgcctttaa gcgctttttt caggaaggtg cttggcacga ttaaccggtt gatttcgttt 3153901 gtgccttcaa aaatccgatt gatccttgaa tccctatagg ccctttctac ttcgtattcc 3153961 tgcataaagc cgtagcctcc atgaatctgc acgccttcat caacgatata atcaagcgtt 3154021 tcagagccga ataccttatt cagagagcat tcgatggcgt attccgcaat cgatttggcg 3154081 atttgccggc cgtccttgag atcttcggcc gtgaactggc tcatattgtc ttcaaacagc 3154141 ccgacggttc tgtatacaga gctttccatc gcatacagcc ttgaggccat tgtcccgatt 3154201 ttttcctgtg tcaatgaaaa accagcaatc ggcgttttaa attggcggcg ctgatttgcg 3154261 tatgccgcag acagctcgat gacgcgttta gatgcgccga ttgtgccaac cgccagtttg 3154321 taacggccga tgtttaaaat attaaaggcg atgacatgcc ctttgccgat ttctccgagc 3154381 aggttttcct ttggcacttc agcttgatcc agaatgaggg ttcttgtcga tgatcccttg 3154441 attcccattt tcttttcttc cggtcccgtg gagacacccg ggaactcttt ttctacaata 3154501 aaggctgaaa acttgtcgcc gtctacctta gcgtaaacta caaatacatc ggcaaaagca 3154561 gagttggtaa tccactgttt ttcccctgtt aatacataat gggttcctgc ttcattcagc 3154621 acagctgttg tttttgctcc aagtgcatca gacccagagc caggctcagt cagagcataa 3154681 gcggcgatct tttcgcctga agcgagtcca ggcaaatatt ttttcttttg ttcttctgac 3154741 ccgaaaaaga cgatcggcaa ggaaccgata ccgacatgcg cgccataaga aagagaaaag 3154801 cttcccgcac gcgaaaattt ctcagtgatg agtgccgagc tgattttatc aaggccgagc 3154861 ccgccgtatt cttccggcac atcggcgcca agcagcccta gttcgcccgc tttcttcaac 3154921 agtctgacag aatgctcgaa ttgatggttt tcgatatcat ctatatgagg gagaacatct 3154981 tgctcgatgt aatcctctgt tgttttcgca atcattttat gctcgtcagt gaaatcctcc 3155041 ggtgtataca tttgatcgta tgtgacatcc tcgattaaaa atccgccgcc tttttgtacg 3155101 tcagccgctt tttttgccat ttgtttttcc ccctttagca taattcaaat acaccggccg 3155161 ctcccattcc gccgccgata cacatggtca cgactccaaa ttgctcgttt ctccgtttca 3155221 tttcatggat gagtgagagt gtaagctttg tgcccgtaca gccaagcggg tgtccaagcg 3155281 cgattgcgcc cccgttgaca ttcacttttt cttcatcaat tcccaattcc ctgattactt 3155341 gaatggcctg tgaggcaaaa gcttcattca gttcaaacaa gccgatgtcc tgcagctgaa 3155401 gtccggcaag cttcaaagcg cgcggaatcg cttccaccgg tccgattccc atcacttccg 3155461 gcggcacgcc gcctaccgca aaggagcgga atttcacaag cggcgccagg ccaagagcat 3155521 cggctttttc ccggtccatc agcatgacag ccgccgctcc gtcactcgtt tgtgaggaat 3155581 tgcccgcagt caccgtcccg tcaacggaaa aggccgggcg caatgtcgat aagatgtctg 3155641 cagtcgtttg cgggcgaaca ccttcatcct gagaaaacac aaactgtttt tccataggct 3155701 tatggtcttc tccgatttct gtcaccgtca cttcgacggg tacaatttca tctttaaatt 3155761 ttccttctgc aagggcttta gcggcgtttt gatggctgcg aacggcaaac gcgtcttgat 3155821 cctcacggga gacgccgtat tttttcgcga cttgctcggc tgtgtgcccc atgctcatat 3155881 aatattccgg tgccttttct gccaaagcaa ggttcggacg ggtaacatgc cccatcatcg 3155941 gaacttgcga catggattct gctccgccgg cgatcgctgt atcgtaggcg cccagcataa 3156001 ttttttctgc tgcatacgca atagactgaa ggcctgaaga gcaatagcgg ttaactgtaa 3156061 tcgccggaac cgtgtacggc aggcccgcga gcgcaccgat atttctcgcc atattaagcc 3156121 cctgctccgc ttcaggtgtt gcacagccga taatcaagtc atcaatattg ccttcgtagc 3156181 cgcctgcccg tttcagcgtt tcttttacac aaatcgctcc caaatcatcc gggcgaacgg 3156241 tggccaacga tccttttttt gcttttccaa ccggtgttct tgcacctgac acaatgactg 3156301 cctctttcat aagctccctc ctaattccgt aaaggtttac ctttcacaag catatgctgc 3156361 attctcgctt gagattttgc ctctcctgac aaactcaaaa acgcttctct ttcgatctcc 3156421 aataaatact cttcatcaac ctctgtacca aacggcactt ttccgcccgc aatgacataa 3156481 gcgagttttt tcgcgatctt aaaatcatgc tcagatatat agccggacag cttcatctgc 3156541 tcagcgccaa gcaagagtgc cgcataaccg gtttctcccg gcaccttgac cttttctttt 3156601 acaggcggcc gccagccggt atcgtataaa gatgcggcca gctgcttcgc atcgtataac 3156661 aggtggtctt gattcacgct gatctgatcc gtttctttta agatgttcat ctcacgagcc 3156721 tcttgagcgg aagcggacac tttcgccatc gcgattgttt caaatgtttt cattgccgca 3156781 ttcatcggat catggccgcg gcgaagatgg ttgatgtaca gctctttgtt acctcctccg 3156841 ccagggatga ggccgacacc ggattccaca agtcccatat aggcttcgct tgccgcttga 3156901 atgcgcgccg ccggcaggca tgcttccgtt cctccgccga gcgtcatgcc aaatggcgcg 3156961 gcgacgaccg gtttcgcact gtatttgatc ttcatcatcg tctcctgaaa acggcggatc 3157021 acaaaatcaa cttccaaaaa gttgtcatct tggacttcca ttaagatcat ggcgagattc 3157081 gcgccgacgc agaaattttt cccttgattg ccgatgacaa gccccttgta attccgttct 3157141 gtttcctcta atcctttgtg gatcatttga atgatatcga ggccgatcgc attgcttttc 3157201 gaatgaaatt caagaagggc cacatcatct ccaaggtcaa ttaagcttgc tccgctgttt 3157261 ttcgcaatca cgccttttgt ttctttaagt gcttgtaaat gaattcgttt tttgttttct 3157321 ttcacggctc tgtattcgcc gcggtcataa taaaataccg ttccgttctc tttgatgtag 3157381 aaggtttcat ttcctttgtc cagcatctct tttatccagc caggcatatc tgctccaagc 3157441 tgctcaagct tttccgctga ctgcttgagg ccgatggcgt cccacatctc aaaaggtccc 3157501 agttcccagc cgaatcccca cttcatggct tggtcaatcg catgaatatc atcggcaatc 3157561 tcgccaagca gctcggctga gtaaagcagg gtttgagaag tgatattcca cagcaaacgg 3157621 ccggccctgt catccgaata aataagcgct ttcattttgg cttttgtccc ttttgcctgt 3157681 tttgccgctt caagtgccgg tgatttcatt tttgtccgct cgccgtaagt aagcgtcact 3157741 gggtcaagct cataaatcgt ttttccttct tttttataaa agccttggcc ggccttgctt 3157801 ccgatccacc ctttttccag catatcgttc atgaagcttg gaatgcgaaa cacttctttt 3157861 tcatcgccat cagctttgtc atacacattt cgggcaacgt gggcgaatgt atcgaggccg 3157921 accacatcaa gcgttctaaa ggtggcgctt ttcggcctgc cgatcagcgg tcctgtgatc 3157981 gaatcaacct ccccgacctg ataaccgcct ttcagcattt cttggactgt cacgagaagc 3158041 ccgtaagtcc cgatgcggtt tgcgataaag ttcggtgtgt cctttgctgt aacaacgcct 3158101 ttcccgagga cattttctcc gaaagctgtc ataaacttta aaatatcagg atccgtttcc 3158161 ttaatcggaa tgatctctag cagctttaaa tatcgtgcgg gattaaaaaa atgcgttcca 3158221 agaaaatggg ctttaaaatc atccgaccgg ccttcagcca tttcctgcac tgatatgccg 3158281 gatgtgttgc ttgagacgat gcttccagtc tttcgatgtt catccacaag agcgaaaatt 3158341 ttctttttga cttcaaggtt ttcgacaacg acctcaataa tccaatctgc ttctttcagt 3158401 ttttctgcat catcctccag attgccaggt gtaatatagg aggtattttt cgctgatgtg 3158461 aggggagcgg gcttttgttt cagcagtttt ttcatcgcct gccggctcag cctgctgcgc 3158521 acctccgaac tgtccttcgt cagccccttt ttttcctctt cctttgtcaa atcgttcggc 3158581 acaatatcta gcagcaggac aggaattccg atgttagcca aatgcgccgc tatcccggaa 3158641 cccattaccc ccgatcctaa aacggctgcc ttccgaatgt gtttgtgcat gagatatccc 3158701 ccttgaacat tgaatgaata gtcattcatt ttttgactaa aaaaaatgaa acccgtttct 3158761 tctttcatct taaaagattt ccggttcgac ttcaatagct aatttgttat ttttttgtat 3158821 gaagcctata aaagtcgggc aacttaagcc cggaggtgaa gggaatggta cgagagaaaa 3158881 aaaatccgtc ttcagcggca gtcagcgcgg cgagcgtaaa gggagatgcc ggtccgactc 3158941 agcattacgg cggcggaaaa cggacaagtc aaaatcagca gtataaaaaa cataacatgg 3159001 gacaatcata atgcagctgc ttcccacggc tgctttcact ttttcaaaat tccttttaac 3159061 acaaacgctg cattggcagg ccgttcggca attcttctca taaagtagct gaaccagtcc 3159121 gttccatatg ggacatacac acgcattctg tagccttcct tggcgagttc cttctgacgc 3159181 tccggcctga tgccgtatag catttgaaac tcaaattgcg atgcggggat ttgatgttcg 3159241 gcgacgagct gtttcgtaaa tgcaatgatg tcatcgtcat gtgtggcgac agccgtgtag 3159301 ttcccgctta acaactgcag ctttattaag ctctgaaaat gaaggtccgt gcctcttttg 3159361 tcgggaaacg ctacagccgc agattcttta taagcgcctt ttacaagtct gagattcggc 3159421 tttaagtccc gcatctttct gatatcttct gccgcccggt acaaatacgc ctgaatgacc 3159481 gtgccgagct tctcaaattc ctgtttgcat tgcctgtaaa tagaaagtgt ctgttcataa 3159541 tgagaatagt cttccatatc aatggtcaca gcaacatcat attgcttcgc aacggaaaga 3159601 atggcgcgca aatgagtaag agcaagttct tctgaaagat cgagcccgat tgaggtcagc 3159661 ttaagtgaaa gctctgaatt caattgatgt tcggcaatgg cttgaatggc tttcttgcat 3159721 tcctctgcga cttggtttgc ttctttttcc gaagctgcat actcgcctaa ataatcaatt 3159781 gttgcacaca aaccggatct gtttagcctt ttgacggtct taaccgccga ttcaatcgta 3159841 tcccctgcga caaaccttcg tgctccaagc cgcgttccgt atgcttttgc gaacttggta 3159901 agtgttttat tttgagataa gaataaaaac acatgtctca acatccgact ccctcccgcc 3159961 gtcatcttca aaacacctgt atataactcc cagtctgaag gaaactataa aatgaacaga 3160021 aaccaaagga ggatcacaat ggataatcag cagcaatctc aaatgccgcc ttccgttatt 3160081 tcgacaaagg atcatttgta tctcaatgac atgctgaact ggaatttgct cgcgatgaaa 3160141 aaagcgcatt tcatggcgca gcagtgccag gatcaaacgt taaagcaaga actcgaccgc 3160201 gtcggacaca tgcatcatga tcactatcaa agaatattaa agcacctgca gccaggccag 3160261 cagcagtccg gctacatcca ataaggaggc gccagaatga atcagcaaaa tcaaaaaatc 3160321 agcaacccgc agacacctgt accgacaaca tcggaaatga atgacagaga tttcgtcaac 3160381 gaattgctga caaccgaaaa atacatgaca acagcttatt gcactgcctt gcacgaattc 3160441 agccacgagt ctctttatca ggatattcaa tccatttttg atgagtcaca aaaagcgcaa 3160501 agaaaactat atgatctcat gttccaatat ggatggtatt ctgttgaagc ggaggattca 3160561 caaaagctgc agcagtccta tcaaaaattc cagcagacca ttcagcagca gtctccttat 3160621 cagcaataac aacattagta aaaaggatac gatgttcttt cgggcatcta tccttttttt 3160681 gtgtaaaatc agttgacttt tcatttacgc ttatttatat ttaataagca ttaactattt 3160741 tgtcattaaa atatatatac agtgtatgta acagagggga aatgaatatg aagagtgcgg 3160801 atcagttaat gtccgatatt caattatcgc ttcaggcgct ctttcaaaag atacagcctg 3160861 aaatgctgga aagcatggag aaacaaggtg tcaccccagc gcagctgttt gtgctggcca 3160921 gcctaaagaa acacggcagc ctcaaagttt ctgaaattgc cgagcgtatg gaggtgaagc 3160981 caagcgcggt gacgctgatg gcagatcgcc ttgaacaaaa aaatcttatc gccagaacac 3161041 acaacacaaa agacaggcga gtgattgatc tcagtcttac tgacgaagga gacataaagt 3161101 tcgaggaggt tttggcgggc agaaaagcca taatggcgcg ctatctttcc tttttgacgg 3161161 aggaggaaat gctgcaggcg gcgcatatta cagcaaaact cgcacaagca gcagaaacgg 3161221 atgaaaagca aaacatgaaa agaggaaacg gatgaaaatg agtaaagaag gcaaacaatc 3161281 aaaacgaacg ttattaataa caggcttaat tattgccatg tttttttcag cccttgacgg 3161341 taccattgtc ggaacggcca tgccgaaaat tgtcggtgat ctgggcggtt tgagcatgat 3161401 gacctggctg acaactgcat atttgttaac atcaacaacc attgttccaa ttgccggtaa 3161461 actggctgat ttattgggac gccgcattgt ctatgtatca ggtttgatta tttttatggc 3161521 cgcttctgct ttgtgcggaa tggccaacaa catgacggaa ttgattatct tccgtggact 3161581 gcagggcatc ggcggaggca tcatgatgcc gatggcgatg attgtcatcg gtgacttgtt 3161641 cacaggaaaa cagcgtgcta aattccaagg tgtctttggc gcaatttacg ggctggcttc 3161701 agtgattggg ccgcaaatcg gcggctggat tgtagactcg ttaaactgga aatgggtttt 3161761 ctatattaac ctgccagtcg gaattattgc ggttattttt attgccaggg gattacaggg 3161821 acgccagcag actggtccga tcaacttcga tatcgctggt attttcacaa tgattgtcgg 3161881 tgtggtcagc ctcctgctcg ccttaagctt tggcggaaaa gattatgcat gggattcatg 3161941 gcagattctt gggttgttcg ctctcgcact gatcggcatt gtcagcttta tcatcgtaga 3162001 atcaaaagca aaagagccaa tcctgccaat gtatttattt aaaaacagaa catttacatt 3162061 tctaaacttg atcggcttct ttatgagtat cggtatgttt ggcgccatta cgtttgttcc 3162121 tttctttatg cagggaattg tcggtgtaag tgcgtctgaa tcgggtacaa ttatgacacc 3162181 gatgatgatt tctatgatta tcacaagtat catcggcgga cagcttgttt ataaaattgg 3162241 gattaaaccg caaatcatta caggcatgct ggttatggcc ggcggattcc tgctgttaac 3162301 gacattggat ctcgacacga gcaagcttgt cgctacatct tttatggcga ttattggtct 3162361 gggaatgggt cttgttatgc cgattctgac attggcttta caggaaagct tttcgaagga 3162421 ggagcttgga gttgtcactt catccagcca attcttccgt tctatcggcg gaacattcgg 3162481 cattaccatg ctgggagccg taatgaatgc gagatcagga aatctattaa cagataaatt 3162541 ggttccatat ttagactctc ttccggcaca ggcaagctcg tttgccgccc agctaaaggg 3162601 tatgattgat acaaatccgc aagggctgct gcaatcactg ttcagtccgg acgcggtcaa 3162661 acaaatccct gcggctttct catcccatat tgtgccgatt ttaaaaacat cgttgatgga 3162721 ttcgctccac agcgtgtttt atacgggcct gatctttatc gcagtcggag ccgtattcac 3162781 cttgttctta aaacctatca agctatcaaa taagaaagcg gaagaccaac aagaaaaaga 3162841 gaaggcggca aaagccgttg aatcaccttc ccattaatag agcaccccgc gggtatcaat 3162901 ccgcggggtt ttttattcaa tcatctgggc tcttccattt ccgaaagacc aatcctcatc 3162961 ctgatttccg gccagcatga taaacacatc ttcttttctt acaccaagct cggaatgaat 3163021 ccggctcgcg attgagcggt aaagtgcttt tttctgttca gttgttcttg actgtttcag 3163081 tgtaaaatga atgtatatca gttcatcagt acgctcgact tggagataaa atggatcata 3163141 aaaaaattcg cttttttcat attgtctgat gacttggaaa tagtcatctt ccggcacatt 3163201 gatttcttca atcatcgatt ggtggatagt cctgctcagt ttttgaagcc acacttcgct 3163261 tcttcccgac cgtaaatgaa tctgtacaaa tggcatctcc ccgcatccct ttctttacag 3163321 cgtctgtccg ctgtcaattg tgataatttg gcctgtgagt gattcctgtt caattagtga 3163381 acaaatcaat ttggcaacat catctggttc agcaatacac tgcagcagca aagagccgat 3163441 catgcttttc attttttctt cccgtccggc ccaccatctc gttgccacag ctcctggtgc 3163501 tacaccgctc actctgattt caggcgctaa ggcgtgggcc aatgatttcg ttaaaccgtg 3163561 caccgctgat tttgatactg cgtaaggcat tgatgagccg gcaccagtta tccctgcgat 3163621 gctgccgacg tttacgatcg ccccgtcctt gcttttcttc atgaacggaa ccactgcccg 3163681 cgcgcagaaa aacatccctt tcacattgac ggcatacagc tcatcctaga cgtcttctgt 3163741 cgcagcctca agatcatcca ttggaatatg ccgtgtaatg ctggcattgt tgactaaaat 3163801 atcaaccgtg ccgtgtgtgt tcacgattgc ttgaatcata tcctgcacgt cgctgttttt 3163861 ggatacatct gcttggatgg cgaaggcttg cccgccagct ttttgaatca tttccactgt 3163921 ttcctccgct tctgattgcg agcgtgaata attcaccgcc acaatcgccc cacgctttgc 3163981 caattccata ctggctgctt ttccgattcc tgtgccgccc cccgttacga gagctatttt 3164041 gttcaagaca ttcattgccg ccactccttg ctgttgacta aagtatattt ctgattccat 3164101 tgtaatccag ctttgatgtt acgtataatg attgttaaag atactagata tcactcagat 3164161 tgatagtaaa cgaacggagg agttcaaaat ggaaagcgga gatttacgtg tgtttcaaat 3164221 ggtagctcgt gaagggacca ttacgaaagc agccctgcag cttggctatg tacaatcgaa 3164281 tgtcacggcc agaattcaac aattggaagc tgagctgggt accacactgt ttttgcgcca 3164341 taatcggggc atgacacttt ctgcaagcgg aaaattgctg ctggactacg caaataaaat 3164401 tataggcctt cttgatgaag cgtctaaagc gctctcatcc tccgcagaac caagcgggcc 3164461 gcttatgatc ggctgcactc agacaaccgc cgcggtaagg cttccaaagc ttctggcatc 3164521 ttattatgaa gaacatccaa acgtccagct gtctttaaca acaggacata cgcaatttct 3164581 ccttgataaa gttcttcgtt atgaattgga tggcgcgttt atcggatgcg aatgccatca 3164641 tcctgagctc gaatcctatc ctgcgtttga ggaagaacca gtagttgttt cggctgcctc 3164701 cgtgcccgat gttgaggaag ccatcacaaa gccgattctc gtttacagca caggctgttc 3164761 gtatcgagaa acacttgaaa aatggctgcg ttccgtcggt gtcacacagc cggtcattat 3164821 ggaatttggg acgcttgaag caattatcgg cggggttaca gcaggtcttg gcatctcgtt 3164881 gctgccaaga acggttgtgc agaaacatga agcagaagga tcaattcgat tgtacccgct 3164941 gcctgaagct ctcagccaga tgaaaacaga gtttattgtt cgaaaagatt cgtttatcag 3165001 cagcgcgctg agaaccttta tggattcctt tacgccagtt aaaacggctg aatcacaaaa 3165061 aagcagtctg ctataatgaa cagactgctt tttggctatt gtttgtttcg atgcgcttca 3165121 tttaattcct taatatgctg aatgatctct ttaatgccct gcttcgcgtc ggggtatgtc 3165181 gcattccaat gcttagcgag cggaggcatg cttttggcta tatgggtgta caaaatccat 3165241 tgcttcactt cttcttttag ctcatcgttt gtttcaccaa gcagaagctc agtatacttc 3165301 tccagcaatc catcaagctg ctcctgaagt ttttgttcca ttttccatct tcctttcgaa 3165361 aaaacagcaa ggagctttct caattgaaag ctccttcgct gcgttattta tccatgtgat 3165421 gtgaaagccg cttcctggac aatgcatctg cccctgccat gaggaatgca aagaggcgtt 3165481 ccgaagagcg ggtcctgtgt aacctgacag ttcatagaaa acacattttg cacaagatca 3165541 caagtgatga cctcttccgg acggccttct gcataaatcc gtttatcttt tatggccaca 3165601 agatgatgcg catagcggca cgccaagttt aagtcatgga gaaccataac aatcgtccgg 3165661 tcttcctttt cattcagctc aaacagcaaa tcaagaattt caatttgatg cgtcatgtct 3165721 aaatacgtcg tcggctcgtc aagaaggatg atatccgttt cctgggcaag cgtcatcgcg 3165781 atccaagccc gctggcgctg tccgcctgac aaagaatcaa cggcacggtc agccatgtcc 3165841 tcaagctttg ttgctttaag cgctctttca actgcttcct catcctcttt tgaccactgc 3165901 ttcagccagt tttggtaagg atatcttcct tgcttcacca gctgatgcac cgtcagcccc 3165961 tctggagccg aaggaccttg gggcaggatt gcgagctctt ttgcgacttc cttcgtcgga 3166021 agcttggcaa tcgctcttcc ttccagcagc actgaaccgc ctctcggctt catcaggcgc 3166081 gctaatgaac gtaaaagtgt cgattttccg cagccattgc tgccaataaa tacggtaatt 3166141 tcacctttgg gaattgttaa attcaactca tcaataataa cggcatcccc gtatcctaag 3166201 ctcagcgttt ctgtagaaat tgcactcata cccataaccg ctcctttttg ctggcttttt 3166261 agcagcacta tgtattgcac gttttctata tacatgcttt taagtcaatt gtcatcaatg 3166321 caaatgattc cgatattcag ccatttgata tggtcatata tccctcattg tagcagaaaa 3166381 cactgacttt gaaaatcatt ttcaattagt tttatggaca taattgacgt ttatgggttt 3166441 tttatcacaa gattacttct tgatttctct gatggagccg tccttcagct tcaattttaa 3166501 atcgatatga tcataatgac tgtccagatt aaatgctgcc agcacactgt gtatcacttc 3166561 tgtttcagcc atttggtctg tcacggaaag ctcgctcaaa atcattttca tctcatctaa 3166621 cgcttcttct ccttcctgat tgacaccgga gagcttatcc tgtatttccg ctttttcctg 3166681 agtcccgttc tttgtataga ttccttcata acggttatgc tcaccatccc cgtagctcac 3166741 acgaagcgaa aaattactgt agggaacgga cttcagctgg gtgacggctg tattttctcc 3166801 ttctgcctga tgctggtctt cattgaaacg gcagcccgca atcagaacca ctgcgagaca 3166861 tacagccccg gctgctctga tcaaatgcat atgtttcccc cctgtaggat tccatttatt 3166921 ttaggtatat ccagagaatg aaatcctcat tcagagaaga attgaaaaag ccggggcatt 3166981 taacgccacg gctttttctt taagattcgg tcatttgtaa aaaggtttcg gcgtcacgca 3167041 cagccagctt gatggcattc tcccagaaat cgcgctttgt gatgtcagcg cccaaatgct 3167101 tcatcgccaa atcctccact gtcatagaag ccgtatcgcg caatagcgcc atatacttct 3167161 cttcgaatgt gtctttttct tcaagcgcca acgcgtaaat accaagagaa aacaggtagc 3167221 cgaatgtata agggaaattg taaaacggca ccctcgtgat gtgaaaatga agctttgatg 3167281 cccaaaaaag cggatgatat tcttctaacg cattgcagta tgcctctctt tgcgcctctt 3167341 ccatcagctc attcaagcgg ctggccggta ccactccccg ctttcgttcc tcgtagaatc 3167401 tcgtttcaaa tagaaatctt gcgtgaatgt tcatgaagaa cgcaacgctt ctttgcactt 3167461 tatcctccag aagaacaagc ttttcttccc tcgtctcggc ctgctggaca gtcgcgtccg 3167521 ccactatcat ctctgcaaac gttgaagctg tttctgcaac gttcatggcg taggaacggt 3167581 ttaacggcct gacgttgagc attgcttcct gatggaacgc gtgcccgagt tcatgcgcaa 3167641 gggtagagac atttgaggcg cttcccgaaa atgtcatgaa aatccgggat tccccgctgt 3167701 ccggaaaact ggtgcaaaag ccgccgactc tttttccgct cctgtcttcc gcctcaatcc 3167761 agccgtcccg aaacgctttt tcagtgaatg aggacagctt tttgccaaac gttgaaaact 3167821 ggctggtaat gatatttgcg gcttcatcat acgaatagac ctttccgtca gaaccgatcg 3167881 gtgcctcgac atcgtaccag ctgagttttt caaggccgag catggatgct ttccggttca 3167941 aaaactgaac gaacggcttc ttgttttcag tgatgacctg ccacatcgta tcaagtgttt 3168001 cttttttcat cctgttaatt tgcagcggtt ccttcaggac attctcccag ccgcgcgctt 3168061 tataggtttc aagccggaat cccgccaaat gattcagcgt gctgctgaaa atatcttgct 3168121 tgctctccca agcttggcgg aaacgttcat atactgtttt tctgacagta cggtcttgat 3168181 gatccatcat attctccgcc tgaccgacag acaattgctt gttttcaccg ttttcctcat 3168241 acgggatcgt cattttcccg acaaccatat tgtataagtc actccaagcg tgatatccgt 3168301 ccaccgcaag gtttccgatc agtttttcct taccggggct aagcttttcg gcaaccctct 3168361 gtcttctttc atttaatatg taagaaacat cgcgcaatcc cggttttgtt aacaattcat 3168421 tccacacgtc ttgattaatg tccacaagtt tatgatctaa tgtaacgagc gacgattgaa 3168481 aatctgcgga aagccgattc atgaggcctg atgctctata gccttttgat cattgatatt 3168541 ctgggcctgg aggcaagcaa caaaagcgcc ggcctgctga agcttgacgg atgtctgttc 3168601 gaataaatca agcaacgcgg tcagcccttc agcctcttca ggcgattcag gcacctgaaa 3168661 cgcatcagtc ctgtcttgaa atgcacgcag actttgtgac agcttctcaa tataaccttt 3168721 gaattcttcc gattggctcc cgcccttaaa aaatgaatca agatcccatc tttggcctac 3168781 cccttgcagc gccatatcac aaaacccctt tccttctttc gttctattat agaacaattc 3168841 tgaattattg tataaaaatt tctattacag gcgtcatttc gtgttcagga tagtacaata 3168901 gctgtagcag tttaatagga gggttaggat gaataaaaaa atagccatcg tgacaggagc 3168961 gtccagcggc ttcggtctgc tggcagctgt aaagcttgcc cgatcatttt tcgtgatagc 3169021 cacatcaaga cagcctgaaa aagcggaaca gcttcgagaa ttggctgcag cacacaatgt 3169081 gtctgattct attcacatta cagctctcga tgtcaccgat gaacaatcta tagtctcatt 3169141 cggaaaagct gttagtgctt acgccccgat cgatttactc gttaacaacg ccggaacggc 3169201 ttatggagga tttatcgagg atgtgccgat ggaacatttc agacaacaat ttgaaacgaa 3169261 tgtcttcggt gtgatccatg tgacaaaaac cgtgctgcct tacataagaa agcatggcgg 3169321 cgcaaagatt ataaacgtga gcagcatcag cggactgaca ggattcccag cgctgtcgcc 3169381 atatgtttct tccaagcatg cattggaagg tttttctgaa agcctgcgta tcgagctgct 3169441 tccgttcggt atcgaaaccg ctttgatcga gccgggctca tacaagacat cgatctggtc 3169501 aacgtcatta tcaaatttta tgtcggtgcc tgctgacgat tcagcctatc atcaatacta 3169561 taaaaagatc ctttcctatg ttcaaaaaaa cggagaagaa agcggagatc cccaagaggt 3169621 tgccgacctc atttatcaat tggcaacaaa acagcacata aagaatttgc gatacccgat 3169681 cggaaagggc atcaagctca ccctgctgtt ccgatcgctt tttccttggt ctgcgtggga 3169741 gtctatcctg aagaaaaagc tattcagctg atctaaatta taattattat aatttagtat 3169801 tgatttttat ttagtatatg atataattaa gtcaacagat cacaaggagg acgttatctt 3169861 atgaaaactg aaaacgcaaa aacaaatcaa acattagttg agaattcact gaacacacaa 3169921 ttatcaaact ggtttctttt atactctaag ctccaccgtt tccattggta tgtgaaaggg 3169981 cctcatttct ttacattgca cgagaaattt gaagaacttt atgaccatgc ggctgaaaca 3170041 gtggatacca tcgctgagcg cctgctggcg attggcggac agcctgttgc cacagtgaaa 3170101 gaatacactg agcatgcatc tatcacagac ggcggaaacg aaacatcagc atcagaaatg 3170161 gtacaagcat tggtaaacga ctacaaacaa atcagcagcg aatctaaatt cgtgatcggc 3170221 ctggctgaag aaaatcaaga caatgcgaca gcggacttgt ttgtcggatt aattgaagaa 3170281 gttgaaaaac aagtgtggat gctttcctct tatttagggt aacaaaaaag ctgaacctta 3170341 atcgggttca gctttttgtt ttttcttagc ttgaactgct ttctgtctgc ttggtcagtg 3170401 ttgcgttcaa cgttttcgtt tttccctttc gcagcacttg gattgttgtt ttatctccga 3170461 cttttaagtc tttgtaaagg atctgacgga tatccgcact gctttccacg tctttaccgt 3170521 ttagtttgac aatgacatcc tcagatttaa tacctgcttt ttctgccggc gaatttgctt 3170581 gaacttcttt tacataaaca cctttgccca attgatctcc aaacaggccg agcgtatttt 3170641 cctgataggt ttcaggaact tgtgacatgt caatcatctg cacgcctaaa aacggacggt 3170701 ccaccttccc gttttgcagc agctggtcaa caatcggctc gacatcattg cttgggatcg 3170761 caaatccaag tgattccacg ccgctttcgc tcaccttcaa gctgttgatg ccgatgacct 3170821 ggccgcttgc attgattaat gggcctccgc tgttccccgg attgatcgct gcatcggttt 3170881 gcagcacgtt catttccacc gtcccctgtg ttgtatccac atcaattgtc cggttcagtc 3170941 cgctaatgat accttgtgtc actgtaccgg aaaactgctg tccgagcggg ttaccgatag 3171001 cgattacctt ttcgccagtg cgcagctgtg aagagtcacc aaagctcgcc acttttttta 3171061 cattcttgcc gctgatttcc aaaactgcca aatcagtaat ggtatcgctg ccgacaagct 3171121 tggcagtttc cgtttctccg ttgtatagcg taacagtcag cttgttcgcg ccttcaacga 3171181 catggttgtt tgtaatgata tacgctttat cgctgtcttt tttgaaaata acacctgacc 3171241 cggttccgct ttcactttct gagctggagc ctcctcccgt gccgaatgtg ttattttgag 3171301 aggtttggat atttgagatt ccgacaatcg taggctctaa atcctctacc atatcagcga 3171361 tgtttgatgc gttcgttatc ggcgccgttg taaaattatc agactgcacc tgtttatttg 3171421 cggaagcggt ttcggtcgcc tgattttggt ctgacggcag ataaggcgcg atgccaagca 3171481 tgaggccccc gccgataata ccgcctaaaa tcgggctcag ccatgcggct ctccgtttct 3171541 tttctttttt cacagccgtt tcttgctttt ccatttctaa agcagaagcc gtttcctgcc 3171601 gtcccgcttc atacgacaca ggcgcgtcaa gcaattcttg ttcagaatgt ccaatcagct 3171661 tctggttttc tgtattctgc tgttctgtat gtgaaggttc agtttgatgt tgatcgtttt 3171721 ggccatcacg tcgataatcc atgttcttac actcctttaa cggttattca tttatcgtta 3171781 catattcatc gcatgtacaa gttcaattgt cccaataatg aggagaaaag caaagcacca 3171841 aaatagaata tgtttgatca tcctacatct tcctcgctct ttttctcttc ctttcttccc 3171901 ttaaccatat cataaacaaa cattgtggga taaaaatgaa aagaatatgt gaaattatga 3171961 aaattgcctg ccgtatgtta aaactagttt ataatgacgt tgaaaggatg tgaagagcct 3172021 tgtcatacac catttatcta gttgaagatg aggataacct gaatgaactg ctgacgaagt 3172081 atttagagaa tgagggctgg aacattacat cttttacgaa aggtgaagac gccagaaaga 3172141 aaatgacacc gtctccccac ctatggattc tcgatatcat gctgccggat accgacggct 3172201 atacattaat aaaagaaatc aaggcgaaag atcctgacgt gccggtcatt tttatttccg 3172261 cccgagatgc ggatattgac agagtgcttg gcttagagct tggcagcaat gactacattt 3172321 caaagccgtt tttgccgcgg gagctgatta tccgtgtgca aaagctgctg cagctcgtat 3172381 ataaggaagc tcctcctgtc caaaaaaatg aaattgccgt ctcctcgtat cgggtcgctg 3172441 aagacgcccg cgaggtctat gacgaaaacg ggaatatcat caatttgacg tcaaaggaat 3172501 ttgatctgct gctattattt atccatcata aagggcatcc atactctcgt gaggatatcc 3172561 tcctaaaagt gtggggacat gactacttcg gaacagaccg ggtcgttgat gatctcgtcc 3172621 ggagactgcg cagaaagatg cctgaattga aggtggagac gatttacggt ttcggctaca 3172681 ggatgatgtc atcatgaaaa acaagccgct cgcgtttcag atatgggttg tcatatccgg 3172741 catcctgtta gcgatatcga ttttactgct tgtgttattt tcaaacacgc tgcgagattt 3172801 tttcactaat gaaacgtata cgacgattga aaatgagcag catgttctga cagagtaccg 3172861 cctgccaggt tcgattgaaa ggcgctatta cagcgaggaa gcgacggcgc cgacaactgt 3172921 ccgctccgta cagcacgtgc tccttcctga aaatgaagag gcttcttcag acaaggattt 3172981 aagcattctg tcatcttcat ttatccacaa ggtgtacaag ctggctgata agcaggaagc 3173041 taaaaagaaa cgttacagcg ccgacgtcaa tggagagaaa gtgttttttg tcattaaaaa 3173101 gggactttcc gtcaatggac aatcagcgat gatgctctct tacgcgcttg attcttatcg 3173161 ggacgatttg gcctatacct tgttcaaaca gcttctgttt attatagctg tcgtcatttt 3173221 attaagctgg attccggcta tttggcttgc aaagtattta tcaaggcctc ttgtatcatt 3173281 tgaaaaacac gtcaaacgga tttctgaaca ggattgggat gacccagtaa aagtggaccg 3173341 gaaagatgaa atcggcaaat tgggccatac catcgaagag atgcgccaaa agcttgtgca 3173401 aaaggatgaa acagaaagaa ctctattgca aaatatctct catgatttaa aaacgccggt 3173461 catggtcatc agaggctata cacaatcaat taaagacggg atttttccta aaggagacct 3173521 tgaaaacact gtagatgtta ttgaatgcga agctcttaag ctggagaaaa aaataaagga 3173581 tttattatat ttaacgaagc tggattattt agcgaagcaa aaagtgcagc acgacatgtt 3173641 cagtattgtg gaagtgacag aagaagtcat cgaacgattg aagtgggcgc ggaaagaact 3173701 atcgtgggaa attgatgtag aagaggatat tttgatgccg ggcgatccgg agcaatggaa 3173761 caaactcctc gaaaacattt tggaaaatca aatccgctat gctgagacaa aaatagaaat 3173821 cagcatgaaa caagatgatc gaaatatcgt gatcaccatt aaaaatgacg gtccgcatat 3173881 tgaagatgag atgctctcca gcctctatga gccttttaat aaagggaaga aaggcgaatt 3173941 cggcattggt ctaagcatcg taaaacgaat tttaactctt cataaggcat ctatctcaat 3174001 tgaaaatgac aaaacgggtg taacataccg catagcagtg ccaaaataga ctgtagatgt 3174061 tttgcagtct atttttttat gtgaaagaat agccgttaaa atctctgtaa tttgttttga 3174121 gcggctgttt gcattgatga acccattttt tctctgacaa ggtctgcttc ggatatttga 3174181 ctttctccac tttgattcct ctgtttcgca agcggctgat catttcgtcc aattctctca 3174241 ttctagattc accctttcgc ttgagctttg accattcggt catctcaatt tataatataa 3174301 ataatacatg ataaaaaaac aagttacaat aaggttaatt ttataacaga cggtgtgact 3174361 atatggtcat atcctagcag gcctccgggc tccgaaaggg tggaaccatt gaaggaaaaa 3174421 gaaaaactga ttattgaaac agccttaaaa ctatttgccc aaaaaggata caactcaaca 3174481 tcagtccagg aaatcgcaaa agaatgcaaa atatctaaag gcgcttttta tatttatttt 3174541 ccttcgaaag aagcgcttct tctctctatg ctgaactact attatgataa aacgtttacc 3174601 cgaattttaa atattaaaac gaagggcgac agccccagaa cggcttaccg taaacagctg 3174661 accgtcctct atgaaaacat tcttgaacac aaagatttta tcagcatgca gttgaaggag 3174721 ggttctctgc cttacacaga agaagtggag caatgcgcaa aaaaaatccg ccagtcctca 3174781 cttcaatttc atatcgacag cctgctgaac atctatggaa aaaaagcgga accgtacact 3174841 gctgagcttt gttttttaat agagggcatc agccagattt acctggaatg catgattttg 3174901 ctcgggtaca ctgtgaagcc gtctcaatta gctgatatca ttatgaatcg aattgatgat 3174961 atggtaaaag gcatgtctga acgaaacgat aagcctttca tcacattgga agaggcgagc 3175021 tctttattcg gacctcttac gcacggacgg cctgacccgc tgactgaatc aattgtgaaa 3175081 agcctacgtg acaaaattaa cagcttaaac acaaactcct ctcttgaatt atcggagagc 3175141 ttggacatac ttgaagcaga aatgaagaaa aaaacaccga agctggcgat cataaaagga 3175201 atgattcata atctgacgga gtctgaagct ctcgccaaag atgcggaaca gcttaaatat 3175261 ttattaaaac agcaacatat ttagaagaac ggctgcttaa aaagcagccg ttcttcctat 3175321 tacgcctttg gttttaccat gtcttccggc ttaaccattt cgttaaattg ctcctctgtc 3175381 agcaattcaa gcttcaaagc tgcttctttg agcgtcaatc cctctttatg ggcaagcttg 3175441 gcgattttcg ccgcgttttc ataaccgata tgcgggttca gcgccgtaac aagcattaat 3175501 gaatttgaca ggttttcctg aatggtttct ttattaggct caataccgac agcacattta 3175561 tcatggaatg aattcatgcc gtcactgagc agctgcacag attgcaggaa gttgtaaata 3175621 ataacaggct taaacacgtt cagttcaaag ttcccctgac tcgccgcaaa gccgattgtc 3175681 gcatcgttcc ccatgatttg cgctgcgatc attgttaacg cttcgctttg tgtcggattg 3175741 actttaccag gcataataga gcttcccggc tcattttcag gaatgacgat ctccccgatg 3175801 ccgcagcggg gtccgcttgc gagccatctg acatcgttcg cgattttcat taagtcagcc 3175861 gcaagcgctt ttaatgcgcc atgcgcataa gtgatttcgt catggcttgt cagcgcgtgg 3175921 aatttattcg gcgagctgct gaacgtttgg ccggtcagct tagtgatctc ttctgagaca 3175981 agctctccaa actctgggtg ggcgttgata cccgttccga cagccgttcc accaattgca 3176041 agcgcacgca ttttatctgt cgcttccaaa atcatttcct tcgaacggtc cagcatgtga 3176101 acccatccgc tgatttcctg tccgagggtc agtggcgtag catcctgaag atgcgtgcgt 3176161 ccgattttga caatatcatt gtatgctttt gctttttcat ccagtgtatt gcgaagctga 3176221 tcaagcgccg gcacaagctg ctcgtaaaca gccaaaacag cggcaacatg catcgcagtc 3176281 gggaatgtgt cgtttgagct ttggcttcgg ttcacgtcat catttggatg aatcgtttga 3176341 tcagagttct tctcttttaa taaagcagtc gcacggttgg ctaccacttc gttcatgttc 3176401 atattgcttt gtgtgccgct tccggtctgc catacgacaa gcgggaagtt gtcatcgtac 3176461 ttgcctttga gcacatcatc acaaaccgct gcaatcgctt ctgctttttc agcgtccaga 3176521 ttgccgaggc gtttattagc tagagcagtg cttcgtttta aaattgcaaa cgccttcaca 3176581 acacgcatcg gcattttttc agaaccgatc ttaaagttct ccttgcttcg ctgtgtttgg 3176641 gcgccccaaa atttatcagc aggaactttt acttctccca tggtgtctcg ttcaattctg 3176701 tattccattt atgtatccct ccataacggt tgcttcaata gatcataatt cgccaatgac 3176761 acaaaaaatc ctttttattt ttcgatcttg gcagatttta attttaattc aagatatacg 3176821 cgggaatcct ttgaatattt gtattttgga tttgtcctgc cgtactcctt tgatgtataa 3176881 gagacatcat aatgctgttc aaatgatcta atgagctgtt caatttcttc ttgttttcca 3176941 gctagcctta cctgtgccac ttcgtatcct ccgctttcat aaaaaaactt actccatgaa 3177001 atactctaac acagtatatc atttttttaa caggaaaaga taacctctac taaggttttg 3177061 gataagaggt gacctcattg gaacaaacag agtttaagga atatatacac gataatttag 3177121 cattggtgct gccaaaatta aaagaaaacg atgatctggt gaaaaacaaa aaaatgcttg 3177181 cgaacggact ggttttttac tatctctatt tcagtgaaat gactgatgag aataaggtgt 3177241 cagaagccat taaaactttg attaaagatg aggagacctt aacgcttgac caggtcaaaa 3177301 aacgccttga ccagcttgac gcaagacctg ttgaaactgc aaaaaaaacg attgaatcga 3177361 ttctcaacgg caattgtgct gtgtttatca acggattgga taaagcctat attctgacca 3177421 caggaaagaa aaaaacaaga agcctgacag agccgacaac tgaaaaagtg gttcgcggcc 3177481 caaaagtagc gtttgtagag gatattgata caaatctcgc tctgatcaga caaagaacct 3177541 ctcatccgaa attgatcacc aaaaaaatca tgatcggcga aaacaagctg aagcctgcag 3177601 ccattatgta cattgaaggc aaagcaaaaa agtccgtcat aaaagaagtg aaggcgcggc 3177661 ttaaaaatat ccagctggaa gatatccagg acagcggaac gctcgaggag ctcattgaag 3177721 ataataaata ttcaccattt ccgcagatac aaaatacgga aagacctgac aaagtatctt 3177781 cagccctgtt taacggccgt gtggcaattt tggtcgacag ttcaccattt gtgctgctgg 3177841 tgccggtttc tctcggcatc ctgatgcaat ccccggatga ctactatgaa cgctggattt 3177901 cagcatctct tatccggtcg ctgcgctttg cttctatctt tatcaccttg tttttgtcat 3177961 cgatttatat aacacttgtt tccttccatc aggggctgct gccgaccgca ctcgccgtca 3178021 cgatttcggc gaacagggaa aacgtgccgt tccctccgat atttgaagcc ctgctgatgg 3178081 aagtcaccat cgagctgcta agggaagccg gactgcgact ccccaatccg ctcggacaga 3178141 cgatcggcct cgttgggggc gtagtcatcg gacaggctgc tgtagaagcg aatctcgtca 3178201 gttcgatttt ggtcattgtc gtcagtgtca ttgccctggc atcctttacc gttcctcaat 3178261 acggaatggg tctgtctttc cgggtgctgc gttttatttc gatgttttcc gccgctattt 3178321 tagggctata cggcattatt ttatttatgc ttgtcgttta tacgcactta acgagacaaa 3178381 cgagctttgg gtctccgtat ttttcgccaa acggattctt tagcctgaaa aatacggatg 3178441 actccattat ccgtctccca attaaaaaca aaccaaaaga ggtgaataat ccaaatgagc 3178501 caaaaacaga ctccactgaa acttaatacc tttcaaggta tttctattgt tgcaaataca 3178561 atgcttgggg ccggactttt aacattgccg cgagcgctga ccactaaggc taatacgcct 3178621 gacggctgga tcacgctgat attagaaggt ttcattttta ttttcttcat ttatttaaac 3178681 acgctcattc agaaaaaaca tcaataccct tcactctttg aatatttgaa ggaagggctt 3178741 gggaaatgga tcggcagcat catcggcctt ttgatctgcg gctatttcct cggcgtagcc 3178801 agcttcgaga cacgggcaat ggctgaaatg gtgaagtttt tcctgctgga gagaacccca 3178861 attcaagtca ttattttaac gtttatttgc tgcggcattt atttaatggt tgggggctta 3178921 agcgatgtgt cgcggctgtt tcccttttat ttaacggtaa ccattattat tttgctgatt 3178981 gtgttcggga tcagttttaa aatttttgat atcaataatt tgcgtcctgt tttaggcgaa 3179041 ggccttggac ccattgcaaa ctcccttacc gtcgtttcca tctctttttt aggaatggaa 3179101 gtgatgctgt ttcttcctga acatatgaag aaaaagaaat acacgttcag atatgcgtct 3179161 ctaggatttc tgattccgat tatcttatat atccttacgt atattatcgt tgtcggagct 3179221 ttgaccgctc ccgaggtgaa aacgctgatt tggccgacta tttctctctt tcagtccttt 3179281 gagcttaaag gcatatttat tgaacggttt gaatcctttt tactggtggt ctggattatc 3179341 cagtttttca ccacatttgt catttacgga tactttgccg ctaacgggct aaagaagaca 3179401 tttggattat cgactaaaac aagcatggtg attatcggca taacggtctt ttatttttct 3179461 ctctggccgg atgacgccaa tcaagtcatg atgtatagcg attatcttgg ctatattttt 3179521 gtctccctgt ttctgcttcc gttcattctc tttttcattg tagctctcaa gaggaggatt 3179581 acaacaaaat gaaaatccgg attttatgta tgtttatatg caccctattg ctgtccggat 3179641 gctgggacag tgagaatatc gaggaattaa gcttagtgat cggaataggg ctagacaagc 3179701 ctgacgatga aaatttagag ctgacacagc aaattctcgt gccgaaaata atcagcgcca 3179761 aggagggctc ttcatctgat ccgacacagc tttctatcac aaagggtaaa actgtccatc 3179821 aaatgatgag aacctctgca ttaaagcata agcctacgtt ttcacagcat ttgcgtctca 3179881 ttctgctttc caaaagcgtg attgcggatc aaattggaat ggacgccatt attaaccagt 3179941 ttgtcagaga caacggaaca aggaggagtt cctacgtctt tatcaccaac ggccgaacta 3180001 aggatatatt taacatgaat gatgaaggcg aacccgcatc caacgtgata tatgatctga 3180061 cagagaataa taaggtgacg atcagaacga tggagccagt tacattgggg gagatctcag 3180121 aacacttaac ctctgacgat tcattcctca tccctcatgt cggtaaggaa aacggcaagc 3180181 tcgcgataaa cggagcctct atcataaaaa ataaattatg gcaccgggac ctcaccccga 3180241 ttgaggttca aaatatcagc ttattttcag gcactgtcga gggaggcgtc attgacttga 3180301 agcgcgatgg ccatctcttt tcttatgaag tatattcaag caatcggaag atcaagacgg 3180361 catacaagga cggaaagttc aaattcaccg ttacccgcaa tattgaaggt cgtctatctg 3180421 aggactggaa tcccaatgaa gactcgttta aggattcata tattaaaagt attgaaaaga 3180481 cagtcgaaaa acgagtacac gaaacagtaa cgtcatttat tacagagaag ctgcagaaag 3180541 agatcaaagc ggacgtaacc gggctgggaa acgaggtcag aattcattat cctcaaaagt 3180601 ggaaaaagat ttcaagaaaa tgggatgatg attatttcag caatgcggaa atagactacc 3180661 gggtcaatgt gattgtcaga gacttcggaa cgaaaggcgc aaacaaatag cagccgccta 3180721 attcacgaga tgatttcggt gtgcgtacac cgccgcctgc gtccggtcac tgacatccag 3180781 ctttgataaa atattcgtaa tatgtgtttt gactgtttta atcgtaataa acagttcctc 3180841 gcctatttct ttgtttgtct ttccttctgc gatcaggcag agtatttcga gctcccgttt 3180901 tgtaagcgat tcatgcggga gcgcgttttc acctgagtgg cgcagcctgg ataatacttt 3180961 tcccgccact tttgactcca gcttcggctc tcccttgctt gcggcgcgga tggcatcggc 3181021 gatttctgcc gcttttgagg ttttcaacag atagctgagc gcgccagctt caataaccgg 3181081 gtacactttg tcatcatcaa tgaagctagt gagcacaata attttcgggt cggaaagctc 3181141 ccggcaaatt tgctttgtag cttcaatgcc atccatgccc tccatgacaa ggtccattaa 3181201 aatgacatca ggcgacagtt ccacagcaag ccgaacacct tcgctgccgt ccgatgcttc 3181261 gccgatgact tcaatatcgg gctgcgcctc caaaaaagcc gcgagcccca ttctgaccat 3181321 ttcatgatca tcaatcaata atactcgaat cacgttcgtt ctctcctttt tcttccggaa 3181381 aaatcgggac cttcacttcg atttgagtgc cttttccttc tactgaaatc acttcggcga 3181441 caccgccgat ttcacttgca cgttctttca tagaattcaa gccgtatgag gaggctttca 3181501 cctggtccat tttaaagcct tttccattat caatcacctt cagacggagc tggctgttct 3181561 ttatgcccag aatcacggtt acttttgacg cttttgaatg tctaaatacg tttgaaaggg 3181621 cctcctgcac gattctgaac aagtggtctt caacaccctt ggatatcgct gtgtcctgta 3181681 tatcccactc aatatcaatc ggctgctttt ttcggaactc gtccaaaagc tccgtaaggc 3181741 cctccttcag cccttttcct tcaagggtaa caggccgtaa atggagcagc agcgccctca 3181801 tctcattttg ggcttcgcct gccatatgct cgaccatcct gatccgcttg actgttttgt 3181861 catcagcatc cttgacatgt tccagcacgg ctgatgtcat catcgatatg gcaaagagct 3181921 gctggctgac cgcatcatga agatctctgg ccaatcgctg gcgttcttct gagataaccg 3181981 acttcttcat ttgagcctgc cattccgcac gttcattgga aagtttctgg agggatgcga 3182041 cttgaagctc cacgcgcttc gccatttcgt tcagctgatc agcagccagg ccgatttcat 3182101 catcaccgag cggcggtatc cgataagcga aattgccgtt ttcaaaggtt aaaatggatt 3182161 caattaatgt atcaatcctt gtcttcaacc ggttgccgta catataccct gaggcgaaac 3182221 cgacggtcac gctgatcaga agcaaaatca ggataaacgg aattccgaac cagcttgatg 3182281 acagcaaaac aagcggatcg agccgatagt aaaacatcat aaaggaaatc aggcaaacaa 3182341 aaaggagcag gctgattccc gttgtcatgc ggatggcgcg ccattggagg ctggcaagca 3182401 ttttttttct catacgtact tcacatccac atcaccgata aataaggaaa cggacacttt 3182461 tacccggcgc tttgactcgc taaaatcagt tgacgcggca tataccttcg tgcttaatcc 3182521 gcttttcttc gagccgatca gattaatgtc tcctataaaa acagccgagc tgacagccac 3182581 ttcaaggtcc gatggtacat aaatatcaac gttaccaatg actccgctaa tgacgattgt 3182641 actttctccc tcgggaatca tcgctttaga taaatcgatt ttgatatcac cgataaaacc 3182701 agagacattt aaatcgttca ggtcaaacgg ctgcttcatc atttgcagct caccgataaa 3182761 aaagctgcgc atgtcgggat gttttacatc ttttggcggc tcatgatgtt cttttttatt 3182821 gagattgacc tgtttctcat tcggttcaaa tatcggcttc cctttgataa gcctgtagcc 3182881 ggcgtaaatc agaaatgcgg caaacgcata gccgaataaa ttaaaggtga tgctgaagag 3182941 gtttttcaaa aatagaaacg cggcaaagat atacatgacg gagccaagcc aatcacggga 3183001 atatttttta aggaaatagc cggcaatcag aaaaaagagc ggccaaaaca gcagatcgcc 3183061 tattccgata atttgcaaaa acatactgat gccgaataaa gcaatgatca atccgagaag 3183121 ctgttttttt gtcattcctg gtgtccgcct cctttcttct gcctagtgct accgtatcgc 3183181 tagatccccg ctgtccgttt tgatgtcgat tggatgccgg ccgcttcctt gcgtgcctgt 3183241 gatgtgatgc tgttctttat gtcctttatc agcaaatgaa tacggcgaac tgacgtcacc 3183301 gcttgctgat aaagcattga ctgcaaagct gccattttgg ggaaggctta cattagcatc 3183361 accgcttgtc agcgtgacag atacgggacc ggttaccttt ttcaatacag cattaaaatc 3183421 tcctgaagtc attttcacat caagagagcc tgatacatga accagatttg cgtcccctga 3183481 agctaaatca atgccggctg ttttggagac ggtatttgaa atggaaacat cccccgatga 3183541 tgccttcact ttcagatctt gaatgcggac gtccgtcacg ctcgtatttc cgctcgcaga 3183601 tactgcgttc agcccggaaa gcgcaagatg gtcattcccg gccacagaca cgtcaccgct 3183661 tgaggttcgt actgccagat cacctttata atcatacgga agcctgacga taagagttga 3183721 acggttaaat ccattcaaaa attgaaattc tttttccttt acggtcagct ccagttttct 3183781 tttgttttca gtaacaaata actttcctga gtctcctgaa atgcctgccg atatgtcact 3183841 tcgttcttcc gctataatcc ggacatcctt gctatccgac tcaatgacca tgctgtcaat 3183901 gtcccgcggc gatgcgctgg ctgaatcagc ttctgtgcca tttatgaaac ctaggcctgc 3183961 agcaaacaca tcttttacga cgacggcgaa aaaaaccaga ataccggcag tgatcaacag 3184021 tttgccaagc atttttttca ttcggtttca tccttctcat tcattctatt ataaaggaaa 3184081 agcttgcgaa ttgatacgtg cggaagggaa ggacttgacc gcaaatcctt ccccgttccg 3184141 cttattcatt tgccgctttt gtctggtctg atttttgcag tgaaagtgtc cgcatttttt 3184201 caatctccgc ttccacatcg tctgcgaatt ctttacgtgt aagttctgtg ccggcttccg 3184261 ctgactttga ataattcgcg cggatttcca tttcttcaat acgattttca atacgtaaaa 3184321 attcacgata cgcgctttca ctgtcaattt tgtcaaatgt cgtattcata tgctctttag 3184381 ctttcgccgc atttgcccgc gcaatcagcg cctgtttttt atcctttacg tcctgaagct 3184441 ttgtttcaag tgcagccagc tgctctttca gatcagccag ctgactgttt gcctgttcat 3184501 aggaagcttt atgctcagcc gccttccctt ctaaatactt catttcagtc agcgcctttt 3184561 tcgccagttc ttcttcacct gcgtcaaatg cgagctgtgc ctgatttttc cgtttgccag 3184621 ccacttcagc ggcttcttca tattttttct taaattgata ggcaatcgtg tgctgtttca 3184681 caattgtttg ctttgctttt gcgatgtcgc tttccatatc gcgtacatat tgattcagca 3184741 tcacctttgg attctccatt ttatcaagtc cttcatgaac tgacgcaaca aacatgtctc 3184801 tgattctttt taataccata cctgattcct cctaatatat tgatattatt ttttcttcaa 3184861 aaattcttcc cattcgtcat caaagtgaga ttggtaggca gcagaagccg gttcaggatc 3184921 aaaagatgat acaccgttat cagctgatcc gtttttcatc agcttccagc cgtaatacac 3184981 catagcggcc gccaatgcga ttccgacgac aaacggaagt gagcagatga gcataatggc 3185041 tccgataccg cccacgatga ttcccgtgat ggtttttccc gcggcaaacc ttttgattcc 3185101 tgcgtatgtc atcaagctcc cgatggcgag cgggatgata aagccgaagc ttcctcctcc 3185161 aaaaaagacg gagatcccaa atacaattaa taagaatccg cctattgttt tcttgtttat 3185221 tttcatgcag atcctccttt cgttttcctt gtcttcatct tatacaagtt ggaagatatg 3185281 caaaacgaat cagagattga tttttatata agaccggagt cgtatctcgc accggaccca 3185341 ttggcacaaa aaaacgccat gcacgaggca tggcgtttta aaacccttta cagatgaaca 3185401 cttgcttccc tttctttaat taggtcggac ctttctgctt tggccaattt tgtaaacagc 3185461 aagattccga tacccgcaat aatttcgaca atcccaccga cagcgatcac tttacctgag 3185521 ccgaaagcat tagcggcata cccgcaaatg acagctccgg cagggatcga aatatttgag 3185581 atcatatgta taacggcgta aacctgcggc tgatcctcac tatccacaga cgtctggata 3185641 atcgtgtact caggaacatt aacagcactg actgcggcac caaaggtaaa agcagcgaaa 3185701 aagacgagcg gcaaaaaggt attcatcccg gtaataaaga aagcaaatcc ttcaataatg 3185761 ccggcagtga cgaataacaa gccgtacctg tttaccttga ctttcgccag cacaaaccct 3185821 aataaaaacg cgcccgcggc ggtggtggcc tttaaaagcg agtatacgat cggctggccg 3185881 tttaaatctt ccgcaacgta tacggcagag agcgcttccc atggggcagc cgcgaaattc 3185941 ataaagatac agtaaatggc gagcggatat aaaatctggt gttttctgac gagcctaaag 3186001 ccgcgtttca gtcttccgat atatgtgcct ctctgtgtaa caaccgcaga ctctgattga 3186061 gattcaaccg cagtgtactt aataaaaaga acgagaaaac ctgacaccaa atagagcaca 3186121 agtgcgataa gcatggtata agaaggacta ataaatgtaa gaaaagcgcc gcataatgtg 3186181 acagccccaa gccggacaat ttgagcggag gattgcagca cagcgtttgc tttttgaatg 3186241 ccctgttcat tgacgatttg aggaatcaaa gcgatagagg cgggattgta ggcagctcca 3186301 gtagctgaat gcacaatcat aagcgtcatg acaaaccaca gcggagagaa gcccgcaaaa 3186361 tgacatagag ggataatcaa aacaatcgcc gcccttgtca gatctgaaaa gtacatccaa 3186421 aatttcagcg tggtctgttt cataaaaggc cccgtcacag gcgccagaac ggcttccggc 3186481 aaaaacgtga cagcaatcaa taaagcagtg ccgatcgcac ctttgccgtc ataaattaaa 3186541 aaccataata ttgaattaaa tgcgaacata tcgccggata tcttgactat tcttgagaaa 3186601 aacagataat tgaaatttct cttccagatg ctatcacttt caattaaatt caccatccat 3186661 cagagccccc cgttgcctat tttttacatc tatttattac aatatctcat ttttccattt 3186721 ttcagtcaat aattcataag gttcattttt tgtcgtaaaa tgggaaattg acagagtgaa 3186781 aaacaaaaaa agccggcatg tatttgaaca cgccggcttt ccttttcact ttttatgatt 3186841 cgctgctgtt tcggtcccga aacacaatgg cacttctttc atattctaca tcgccaatac 3186901 cgcttcttgc attcacaacc cgggcggcgg caaagaaata atcggacaga cgattgagat 3186961 aacgcagcac tgtttcatga atctcctccg atttcatcag cgccaccact cttcgttctg 3187021 cccgccttgt aatggtgcgt gcgatatgga gaagcgaagc acactttgat ccgcctggaa 3187081 gaataaattt cttcagttcc ggcgcttctg ctgtataggc atcaatgcgc gtttctaaaa 3187141 aggaaacaga ttcttccgtt agtttatagt cttttctttc tgtgacgatt gccagatcgc 3187201 ctccgcagtc aaacagctca tgctggatgg tcagcagctc ggctgtcaga tcttcaaagc 3187261 cgggctgccc ggaaagctct gccaaagcaa gcccgataaa gctgttaagc tcgtcaatcg 3187321 tgccgtagct ttcgacgcgt aggctgtcct tgtccgttct gcccccgact aagcccgttt 3187381 gtcccttatc gcctgttttt gtatatagtt tcataccctg aatctccttt acagacttat 3187441 tcaaacaact cagcagcctc ttttatacat tcagctgtcc ctttctttat caattggttc 3187501 agccgctgtt ctatgttttc tgattgctga gtttgagtcg cggcgatgag aatatcacct 3187561 gtgcctcctc cgtctcccag cactttcgtc cgttctgctt cggcagccat aagagctttg 3187621 atgaagaatt gatctgccgc atagccgtta atcaaaatcc aaatcgaaaa gccggtctga 3187681 acgcatatga aaacggataa ctctccgtct tcatatgttc gatacacgaa acggtcaagt 3187741 ctttctgaag aagccatcgc acacgtctcc tgcagttgaa aaccgctttc tgaaagacag 3187801 gccgtaagtc cttctatcgg atctggctga tctggcagcc gtttatggat cagcgtcctg 3187861 ctccacgaaa accctgcacc gataggcgtg gaggacaatg ttcgaagcgg gatttccgtt 3187921 tgcagaagaa tgtcatcacg ccccgcttgg agcaatgctt caaatgggat agactgccgc 3187981 ttcacgctat ctttttcagg ctgaatcaca atcatcggtt taggtgagct ttgatgaacc 3188041 aaggcggtga catctgtatc gtacaccgcc tttatgcttt gttctgtaac agcatattcc 3188101 ggtttttgct taggcccggc ggtaccgttt ttcataaaca tgagcccatc acagtacagg 3188161 cttgcggtgt tcagatcatg aaaaacgctg acagctgcca atccgctttc tctcgtcagg 3188221 cgtttgatca gatcaagcag gtctttttga taagccagat cgagaaaatt agtcggctcg 3188281 tccaaaaata aaatacgcgg ctgctgcgcc aaagcttgtg ccaaatacac ccgctgctgt 3188341 tcccctccgc ttagttcgcg aatcggcttt tgcgcaaaat cggccactcc tgtttgctcc 3188401 attgcttcct gtacaatggc ttcacccttt tcagtctgct gtctgaacag ccccgtttgg 3188461 aatggatatc tgccaaaggc tacagtttct tcgacagtaa aggtgaaggc ttgatccatt 3188521 ttttgcggca ggacagccat gatttgcgcc agttccttcg gtttatagtc cgccagcagt 3188581 tttccggcca gataaaccct gcctttcttg gccggcagcg tacctgtcag caagtgcaaa 3188641 agcgtggttt ttccgcttcc attagggccg agaattccaa gaaattctcc cttctccact 3188701 gttaagctga cattgttgat taggcggctg tcgccgtatc ctcccgacag cccttctgcc 3188761 ttcatcataa gcttctcccc ccgcgatgct gccgaattaa aataagagcg aacacaggcg 3188821 ctcccgccaa ggacgtaatg atcccgatcg gcagttcaat cggctcaatg atggttctgg 3188881 aaagcagatc ggctaaaaca agaaaccctg ccccaagcaa ggcggacaac ggcagtaaat 3188941 gccgatggtc cgttccccac aaaagccttg tgatatgcgg aatcacaagg ccgacaaagc 3189001 caatcgtacc cgatactgcc acagcgcttc ccgtcaaaag agatccggct attaaaatca 3189061 tcatcttcct ctgctgaacg ctgactccaa gaagctttgc tttatcttct ccatatgtca 3189121 tcacgttcag ttcccttccg tttataatca ataaaatggt tcccaaaaga aaaaacggga 3189181 gaaacaaaat aacatagctc cagcccctca ttgagacgct gccaagcagc caatgcacaa 3189241 tcggaagcag gttgtctcct gtcaaggcga tgataagaga aataaatgcg cctaaaaaag 3189301 agttggtgat gacaccggtc aaaatgaggg tggaaacaga catcgaagca tgaacgaggc 3189361 ggctgaagaa aaggaccgcc gccatcgtgg ccagtgccgc ggctacactc aaaaccggga 3189421 gtgtaaaccc tccgatgaca ggaaggtgca aacctaagaa cagagtcaca acagctccga 3189481 ctgaagcacc ggatgacaca cctagcgtat agggatcagc aagcggattt ttcaacaatc 3189541 cttgaaaagc ggcccctgca atagaaagag ccgcccccac aagggcggcc agcacaactc 3189601 tcggcagtct gatattcatc ataatattag tgtacatcgg atcatcagaa ccgatagagc 3189661 cgccgaaacc ttgatgccaa aagacacgaa aaacagcggg aataggaata tgcaggctgc 3189721 cgcaagaaat tcctaagatg atgctcacgg ctaaaaatga gaaaccaatg atatatgcgg 3189781 cataacgatt attccttaaa cgtatccggg taaatgcttt ccgcaagttc ttcgacccct 3189841 tcgatcagac ggggaccgga acgtgtcaca agatcagggt ccacatcata tacacgatga 3189901 tgtttcacag cattgatttc gctccagcca tcgcgttttt ccacagcttt cgctttcaca 3189961 ccgtccgttg taacaattgc atcaggattg agttttacga tcgcctcgtc tgtcatttgc 3190021 acccatcctg tctgatccgc agctgcgttt ttagcatgga tgacatttag catttcattc 3190081 ataaacgtat cttttccggt tgtataaatg tcaggatcag gagaaacctc gataaatacg 3190141 cttttctcct cgtcttttga aatggttttc gctttttctt gaatatcctt tagatctgat 3190201 ttcatgcttt tcacgagctg atcggctttt ttctccgccc cgccagcttc tccgatcatt 3190261 tcgattgatt tgtacacctc ggagaatgat tgtgcatcat tgacagtcag cactgtaatg 3190321 cccgcgtcct tcagctgttt gatggcatcc gctgatgctg acatggaaga ctcatgggcc 3190381 agaacgagat ctggttttag agaaatgact ttttcaacgt ttacattcat atctccgact 3190441 ttctcaacct ttttgacttc ctttggatag gtatcgtttg tggtgacacc gaccactttg 3190501 tcaccaaggc cgagtgcgta tgtaatttct gtgttgctcg gcattaatga aacaatcttt 3190561 tttggctctt ttttgatggt tacatcttgg tttgacgcat catcaatggt gacagggaac 3190621 acttctgttt tttgttttgc ctttgaatcc ttctgatccg caggattgcc gcagcctgcc 3190681 agcataacag cagccaacag aagcgcagcc catatcccgg ctcgtttttt cataatcttt 3190741 tcctcctaaa cgaactaaaa aagcatctct acgacggtaa agatgctgta aacaacacaa 3190801 aaaagcctat tgtttacaca tcatctgtcc tcgcagaatt cgtgctgatc aaacaggcag 3190861 gtatcctggc tcttggcgct tggccaatta cagtggcggg accgcaccgg cttttaccgg 3190921 tttccctttt aagccggctg ttgttcacgg accggcacct atttgacatt cgtatccgtt 3190981 tttcggagta attatactat atgactgaca ggcttgtata tgtgtcctga atgacttttc 3191041 cccatattgt gtatggaagc aaaatcctcg taaacactaa atttgatctt gtatacttaa 3191101 taccatcatc tatcaaaagg aatgattctt atggatttac agctaaaaga aaaactcgtc 3191161 ttaatcaccg gctcgacgtc cggtatcggg aaagccgccg caaaaagctt tctgcaagag 3191221 ggtgcggcag tcattgtcaa cggacgcaaa caggagactg tcgatcgcac cattgaagag 3191281 ctttctggct atggaacagt gcacggtgct gctgccgatt tgtcaaaaac agatgaagca 3191341 gcggctttta tcgaaaaagt aaatgaaatc ggtgatatcg atatccttgt caacaacctt 3191401 ggtttcttcg aggtaaaaga cttcgccgat gtgacagatg aagagtggaa tcaatatttc 3191461 gaagtgaacg tgatgagcgc cgttcggaca agccgtcact tccttccaaa aatgcttgcc 3191521 aaaaacagcg gccgcatttt aaatattgca agtgaagcag gcgtcaaacc gctgccaacg 3191581 atgattccat actcaatgac aaaaacggca ctgatcagcc tttcaagagg aatggctgaa 3191641 atgacaaaag gcacaaatgt gacggtcaac tcagtgctcc cgggacctac ttggacagag 3191701 ggcgtggcct cctatatgga aggcgccgca caagcagccg gacaggatac agatacattt 3191761 atcaaagact atttcaaggt caatgagcca acctcactta ttcagcgata cgcgacagca 3191821 gaagaagtcg ccaacacaat cgtattcctc gcgtctgacg ccgcatccgc cattaacggc 3191881 acggcacagc gtgtggaagg cggcattatc cgttctctgt agtataaaaa aacgcatccg 3191941 tgtttcggat gcgttttttt tatacgtctc cagcaaatgg taccggctga tatccgcctg 3192001 tttccagttg tgctgaaaac aaccctccag cgtgaggctg ctcgtatctc tctttttctg 3192061 tcatttgttc tgttgccgtt gtaatgtaaa gggtttttaa gtctctgccg ccgaacgcgc 3192121 agcacgtgac atatttagcc ggcacgctga ttgaattgat ttcttttttc tgaaacgggt 3192181 caatgtgaac aacgcggctg ccgccaaaca gcgccaccca cagcatgcca ttttggtcaa 3192241 ttgtcatgcc gtccggcaat ccgtctgact gatcaaaacg atagacaggt tctggattcg 3192301 aaacatctcc gctttgagga tcatagctgt aacgtacaat ctcctgggtc ggcgtgtcga 3192361 tgtaatacat caaattccgc tcgcggtccc aatccaaacc gtttgaggtg gagacttgat 3192421 ccttgatttt gacaagactg ccgtctagat tcaaacggta cagcgacgcc tgtttttgct 3192481 cgccttccat gctcgtcgtc cccgcccaaa gccttccgta cgggtcacat ttagcatcat 3192541 taaatctcag gctctcatgc atgtccttcg gctgtttaat tttttccaag ctgtcatccc 3192601 gaagatgata caggtaaaac ccgtccttca tcgtcataat cagttcatcc tttgaatatt 3192661 tcgcaagcgc cgtcacaaag gatttgaatt tgattgatcg gttgattttt tcttcagggt 3192721 caaagatgtg gagctcgctc cccaggatat caacccaata taagcggccg ttctcttcat 3192781 cccataacgg gccttcacca atcactgccc gagtgtctgc ttccaatact gcatccatgt 3192841 gttacacctc tttagcttca gtctatatat tgttattccc ggcaaagagg tgtccaaacc 3192901 acttgatgtt tattgttttt taaaaaggat ggtaatgacc gttccaatgt tcgttctgct 3192961 gttcacatgg atcgttccgt tatgcagatg gacaagctcc ttggcaatcg cgagcccgag 3193021 acccgttccg gcagttgaat cttttgtgtt cgtccctctg tagtagcggt taaacaaatg 3193081 ggtgatcgtt tcttcatcca ttcctttccc attgtccttc acttttaaag aaatatgatt 3193141 ttttgtttgc tccagaatga cttgaatctc tgttcctttg ccgttgtgct tcacggcatt 3193201 cccaaggagg ttttctaata tgcgcctgaa ccacgcttca tcaagggcaa attcaatatg 3193261 ctcttctttg gatacaaacg agatatcata gccttcagaa aacggatttt tcttaaaatc 3193321 ctcaatgaca tttttaaaaa acgggataag gctagtgagc tttctctcaa taggaagagc 3193381 atcatttttc aggcgatacg ttaaatttaa gtcttcaatc agcttagaca tgtattcaga 3193441 tttttctctg acaacctgcc ccatttcttt cacttcttcc ggcgaccagt catactgctt 3193501 cgactcgagc atcatgctgt agccgtaaat gctgctgagc ggtgttttta agtcatgtga 3193561 caaaccggca atccattctt cccttgtcgc ctggattttt tctctgtttc ttttatccct 3193621 tctcagcgtt tcagtcagct gatccattga ttcaaatatc tcaccgaaga agcggtacgg 3193681 ctgtttgatt tttccctttt tatttttgct gacaggacgg ccttcccggt ttctgggctc 3193741 ctcaagcttc ccttttgaca gattgaccag ccatctaatc gtgtgaaaaa tcggcagccc 3193801 gaatcggaac atataccaaa cggtcatcca aatgatatac atgaacaaaa cggccatcac 3193861 gagaaacatc gcttttaata caaccttcag gaatgatttg ttaaactcct gatcggttac 3193921 atagactggg ttcggcaccg tagcgaccat ccatctgtct ttattgagga tcttaacgga 3193981 aatttcccgc ttatagttcc aaggcttaga gctgtattta agcagctcca gctggttcat 3194041 cgtttttctc tcgctttttg tgctgttgat gctgtcgaga atctttccat tgctgtctaa 3194101 caggtaaatg gcgccttttt tccgtttaat atagtcgatg gtactagact tatagtgcgc 3194161 tagtgagtct atcttttgtt cacgcttttc aacggaagtc aggagctgtt cactttttga 3194221 tttccagccg gacaatagaa gatacgactt atcttcaata ttgatggccc aataattcag 3194281 tttatagtta tgaagctttt tggttttata aatagacaaa agctctttct tggtataggt 3194341 gcccggcacg tcttttggca cgccgtagga ataatcagtg tttccttccg aatcaatgat 3194401 ttgcatccag ccgtgctgtt tatcaacaga tttcttcagg aaattatcca cttcccatgt 3194461 cccgtcttcg tttacatcga gatatgcctc aagtgtgtcg gtcgttgctt tcgtcagccc 3194521 tgaattggat tccgcatcgc taaaacgggc gtctaaatag aaaaacgatg caacaagcat 3194581 aaccgtaagc agcaggatca caatcagcat ctggccgaaa aagtgaaaca aaaacttcca 3194641 tcttaacctc atgaccgctt gccttcagga tttgggataa aacgatagcc gagacctcga 3194701 acggttacaa tatactccgg attgctcgga tcgcgctcaa tcttctccct aagcttgcga 3194761 atatgaacca tgacggtgtt gttgtcaccg taggaaggat agccccatac tttttcatat 3194821 atttgatctt tggaaagcac cacgttaggg tgttcacaaa aatactgcaa aagctgcaga 3194881 agctgggctg aacaggcaac ggcttccccg cctacgatca actcggcatt ttgcggagaa 3194941 aaagtaaagt aatcatatgt gtaggtttga tttgaactcg tttctttcga ttgatatgta 3195001 cgcttgagat gcgctctgat ccgcgccgct aattccagcg gattaaatgg ttttgtgata 3195061 tagtcatcag ctccaaccgc aaagcccgat aatttgtccg cgtcggatga tcttgccgtc 3195121 aggaaaaaaa tcggagcgtc tgaatactct ctgatcaatg tgcaggcttc aaaaccggac 3195181 attccgccca tcatgacatc cagcacaatc aagtcaacct tattggcctt cacaacggga 3195241 atcgcttctt ctgcgcttgc cgcatccagt atatttcgat aaccttcttt ttcgagaacg 3195301 cgtttgatca tgtccacaat cgctttctca tcgtctacga ttaaaattga cgcattttcc 3195361 acttttatgt tcctttctgt cactgttttt ttcatcttat cattatatcg tttatttatg 3195421 gtacattttt gaatacattg gagccttggc aaatcaaaac agcaaaaaag gagcaaacaa 3195481 gcgctccctt ttgatgtttt ttcatatgaa aatattatga gttctcatct accatgtaca 3195541 aaataaactc ccaaaacccc ggtacatcct gacataaaag catatcagcc ttttcaaaca 3195601 ttttgatctt cagctcttgc tctaaatctt ctctttcttg ataggacgta ttgctgagtt 3195661 tttttctgat catcggtgaa aagcatgcaa tcaggtgctc aatgtcataa gtctcgtctt 3195721 tttgtttctt tttttgttca aactggccgt ccacagctta cttttccccc tttttttgcg 3195781 ccgctaactg ctttctgata ttctccagcc cctttttatg aatgttggag atgttttgtc 3195841 gggactcccc taatgaatct gcaatctcct gcatcgtggc accgtgaaga tagactttcg 3195901 tcagcacact tttttgtttg tcagtcagct tctggatcgc ttggtagagc tggtaatcct 3195961 gtacatgctg gctcaaatca tcctgcctgt ctaaaaattc ttcaaatgca tcgctacctg 3196021 tttcggaaga aagccgatct cccgcctccg gatgatcaac cgtcagtgga taccgttttt 3196081 ggtttttgcg aacccgctta tcaaaatcaa tagaaaagat gcgaatcatt gaattcatat 3196141 acttgacgat gcggatttct ttataaaatt gcttaaatag ctcgtccaat gatcttgcat 3196201 ctttttcgtt agggctttcc attacgtttt tgaacaaacg gtaatgctga ggattgctca 3196261 aaaaatgctt cacgatggga tgcttcatta tctccttaca ttttgaccgt aaaagacttt 3196321 gatagtccat caaaccgcct ccctactaaa ttaaatgaag gaaagcaaaa aaaagtaaac 3196381 tactactttc cgcctagtgt cttccaaaat actttgcagc agtttacgtt ttatcggttt 3196441 tcctcactta catacatgac tgcagaaaaa gaagggaggt attttcctat ggatcaggtt 3196501 tttatagagg aagtcgtaaa acagatcggc aatttggggt ttcccgcgct gattgcaatg 3196561 tatctgctga cccgattcga aaagaagttt gatcaactaa tagaactaat gacagaactg 3196621 aaagatcatg caaaaaaata atttttcaat cgaagttgac ttttcactgg tttttttcac 3196681 ttaacaaaac agaagggaaa acgaaaggcc tttcaccttc tctttctgct atcacattta 3196741 aatgtaagga ggaaacattt catgaaaaaa caaaatgaca ttccgcagcc aattagagga 3196801 gacaaaggag caacggtaaa aatcccgcgc aatattgaaa gagaccggca aaaccctgat 3196861 atgctcgttc cgcctgaaac cgatcatggc accgtcagca atatgaagtt ttcattctct 3196921 gatactcata accgattaga aaaaggcgga tatgcccggg aagtgacagt acgtgaattg 3196981 ccgatttcag aaaaccttgc atccgtaaat atgcggctga agccaggcgc gattcgcgag 3197041 cttcactggc ataaagaagc tgaatgggct tatatgattt acggaagtgc aagagtcaca 3197101 attgtagatg aaaaagggcg cagctttatt gacgatgtag gtgaaggaga cctttggtac 3197161 ttcccgtcag gcctgccgca ctccatccaa gcgctggagg agggagctga gttcctgctc 3197221 gtgtttgacg atggatcatt ctctgaaaac agcacgttcc agctgacaga ttggctggcc 3197281 cacactccaa aagaagtcat tgctgcgaac ttcggcgtga caaaagaaga gatttccaat 3197341 ttgcctggca aagaaaaata tatatttgaa aaccaacttc ctggcagttt aaaagatgat 3197401 attgtggaag ggccgaatgg cgaagtgcct tatccattta cttaccgcct tcttgaacaa 3197461 gagccgatcg aatctgaggg aggaaaagta tacattgcag attcgacaaa cttcaaagtg 3197521 tctaaaacca tcgcatcagc gctcgtaaca gtagaacccg gcgccatgag agaactgcac 3197581 tggcacccga atacccacga atggcaatac tacatctccg gtaaagctag aatgaccgtt 3197641 tttgcatctg acggccatgc cagaacgttt aattaccaag ccggtgatgt cggatatgta 3197701 ccatttgcaa tgggtcatta cgttgaaaac atcggggatg aaccgcttgt ctttttagaa 3197761 atcttcaaag acgaccatta tgctgatgta tctttaaacc aatggcttgc catgcttcct 3197821 gaaacatttg ttcaagcgca ccttgacttg ggcaaagact ttactgatgt gctttcaaaa 3197881 gaaaagcacc cagtagtgaa aaagaaatgc agtaaataaa agacttgcgg cttgcagaga 3197941 gcactcgttc tctgcaagcc ttcataagga gctgaaccag tgaaacatca aaacccttca 3198001 aaacgcttat tgcggctctc cataaagtac ttgctggccg cagcagcagt ggtgttgacc 3198061 tattttgctg tcatctatat attgttttct ttagcgggaa cgagctaccg ctcagcagct 3198121 catgtcctgc tttttgccgt ggtattcctt gttctcggat tatgctttga accatttgaa 3198181 cggctgatga tacatagctt tacatttttc aagacaggaa aacgtctatt cattctcctt 3198241 gctggcatcg tacagctgct gtttttgtgg atgactgctc atacaacaga ccaattgatc 3198301 agcgacatct ggctgtccac cacagaagaa atgattgtcg cagccgtttt tttgatttta 3198361 gacaaatgca actcggctct tcccagctaa aaaaagaacg cattccaatt ggatgcgttc 3198421 tttttattca tagcgaagcg cgtctacagg ctgaagcttc gaagccttga tagacggaag 3198481 caagccgaag ataatgccga ctgccattga aaagatgagt gctccgacaa cagctggaat 3198541 ggagacgata aaaggcatcg gaaaaatgac cgtcagcagc ttggcgatgc cgaagcccgc 3198601 cagcacaccg agtattccgc caatgcttgt cagcacgaca gcctcggtta aaaattgaaa 3198661 taaaatcaca cgccgcttag caccgagcgc tttcttaatt ccgatttccc tcgtgcgctc 3198721 cgttacggaa acgagcataa tgttcatgac gccgataccg cccaccaaaa gtgaaatact 3198781 ggcgataccg ccaagcagca atgcaaatga ctgattaaag gactccactt cctgcgcgat 3198841 ctcctgaaga tccattacac tgtactctgc tttttccagc tcagcttctg acagtccctg 3198901 atttaaaaga tctgcagcca ttacacccgc ttcttggata tgctcagaag aatcagcctg 3198961 cacggcaatc tgcgttggcg cgtcaaatcc ttcaataagc ggccacactt ttttcggcac 3199021 gtacaaaacc gggttcgcat agtcgccttc aaacatgctt tcctgttgat ttttttcttt 3199081 aaaaacaccc acgaccttaa acggcacacc attcatctca atgcttttat gcagagcttc 3199141 tccgtctgga aacagttcat ctctgacagc ttcattgatc atcactactt ggtgtgtgct 3199201 gtttaaatcg ttttccgtca gctttctccc ttcggttatt cggattggaa acatgtcgaa 3199261 gtaatcatcg tccactccat acacttgggg atacgaaacg ttagttaaat gaaaaacgct 3199321 cgcgccttct gacaagtaat ataaggataa tcctttgacc atcggatctg atttgatcgc 3199381 ctttactgtt tcttccgcta caggcggcgc ggacgcatac gacacctgag ggccgccgct 3199441 ctcctcttct ccgccagacg gctggtagac aacattgatg gcgttgtttc ccatgccgat 3199501 catactttgc tttaactgct cactttggcc cttcagcatt gaaacaatcg cgatgattgc 3199561 cgctatgccg ataatgacgc caagcattgt cagaatcgat cttaatttat gagagaaaat 3199621 ggattgaaag gagattcgaa tatgttcaag catggctgat atcccctctc tcatctaata 3199681 ccaactctcc gtctctgata aaaacggttc tgtcagcttt tttggcgacg tccgggtcgt 3199741 gggttatcat aataatggtc ttgccttccc gatgcagttc agaaaacagt gccaaaattt 3199801 gttcacttga tttggtatca agcgccccgg tcggttcatc agctaaaata aacctcggct 3199861 gattgacaag ggccctcgct atcgccaccc gctgcttttg gccgccggac agcttaggcg 3199921 gtttgtagga gaccctgtct tttaatccga ctttttccag cgcttcatat gcccgttgcc 3199981 ttctctcttt tttcttcact ttattgtaga tcatcggcag ctcgacattt tgcagcgcgg 3200041 tgagacgcgg cagcaaatga aaagtttgaa acacaaaccc gattgattca ttgcgaattt 3200101 cggctaaagc cccgtctttc cctttcaata tatcgatctg gtcaagcgta taggttcctg 3200161 aggttggcct gtccaaacag ccgataatat tcattaacgt tgactttcca gaaccggaag 3200221 gccccataat agctaaaaac tcccccgcct gaacggtcag attgatatgt ttcaagattg 3200281 gaacttcttc ttttcccagc ttgtacgact tcgaaatatt attcagtgtc agcattgact 3200341 gtaacctgct ttccttcctt gaccgcggga tcaggataga tcacataatc ttccggcgtc 3200401 aggccgctct taatttccac catgtcattt tcatcagtct ctccgatttc aacaggctgc 3200461 ttaaccgctt tgtgattctc atcagctttc catacgtacg gttcgccgtc atcctgaatg 3200521 accatgtcgg acggcagctt gatcgtgtcc gcatcagcat tatcactcat cacttcgatg 3200581 ttgacatgat agccgacttc aagaccttta tggctgtcta ataaaatggt gaaaggatag 3200641 ttagaggact ggggattcat ttcttcatca gcaaagcttt ctgattcttc accctcgcct 3200701 gctcccgctg gaagcttgcc gatcgaggtg acctttcctt tccactcgcc ctcaccgcct 3200761 gttttcagcg tgaccctgac tttgctgcct tttttgatcg tgtccattaa cagctcattg 3200821 atttggcttt tgaccagata tttgcctgtc gaaacaatct ggatatacgg gcctgctgcc 3200881 tggtcgcctg ttgcaccgtc agcgatatcc tgattgacgc tttgaacgat tccgtcatgc 3200941 ttgcttgtaa tgacattgga acctttgttt ttcgtcaggc cagccagttc tttttgatgc 3201001 tgcttcagtt caagctggct tgttttcaaa tcgaaattgg tttgatcaag ttcatcttga 3201061 agctggtttt tctcttcttt tcctgcaact ttcagctttt tttccgtttc cgttattgat 3201121 ttttgcaaac ggttgatttg cagatttgtc atttcaattt gcaaattggc ttgctccact 3201181 tcatcagaat gatcctcgcc ctcatactca aaaagcttat cgcccttttt aacctgatcg 3201241 ccttctttga cgtatgtttt tttaatgctg cctttttctg aatctatgta tactttctgc 3201301 tgtttctcag gttcaacctt tccagaaaac gtttggcctg attctgaatc tcctcccatg 3201361 tataccgcga ccgattcagc atagggctcc gatgatacgg caacttggtt catgtgagta 3201421 aaaaagtaaa aaccgccagc gccgatccca gccaatacaa gcacaccggc acatatcgca 3201481 ccgccaataa gccatttttt cttcttggac acaacgatct cctctttctg taaactatgt 3201541 aatattttcg aaacattcta accaatatta tctattaatt caaaaagact tgcaatcctt 3201601 ttattgaaat gacggaatca aatagaaaaa ttgtattttc aaagccgaat aaaaaaaatc 3201661 ccggcttcaa accgggattt tttcatacag taactagctc tttttcattt ttaatcaagt 3201721 catatgtcaa gcatacaggt ttatttgtac ggggatcagt cacgatttcg gcatcaatct 3201781 gaaatacctg cttcaaaatg tctggtgtca tgacctccag agcagttcct tccttgatga 3201841 ccgtgccttt tttgagcgcg atcatataat gagaaaaacg agctgcatgg ttaagatcat 3201901 gaatgaccat taaaatcgtc cgcccttgct ctttgttgag tctgtcaagc agctgcagaa 3201961 tttcaagctg atgtgcaaga tcaagatacg ttgtaggttc atccagcaga agcagttccg 3202021 tcccttgcgc aagcgccatg gcaatccaca cacgttgacg ctgtccgcct gacaatgcct 3202081 caatcggccg ttcagcatat tcagccatgc ctgtttcttc aagcgcccat ttgataatcc 3202141 ggcggtcttc gtcatttaat ctgccgaatc ctgattgatg cggaaacctg ccgtacgaca 3202201 ccaattcgtg cactgttagg ccgctcggcg cttcaggtgt ctgtggaaga atcgccatat 3202261 cttttgcaat gtcctttgta gacattttat gaatcgcttt gccgtttaaa tagacggcac 3202321 ctgcatgtga acgcataatt ctggacattg tttttaaaat cgttgatttc ccgcagccgt 3202381 tcgggccaat taaggtggta attttccctt taggaatcga tatatttaaa tcctctacaa 3202441 tcaccctgtc gccataaccg attccaagct gttccgttga taatgaattc atattcggcc 3202501 ccctcctcta attcgctttc atcaataaat aaataaagta aggcgcacct agcacggaaa 3202561 tgacaagtcc gaccggaatt tctgatggtg ccaatacatt tctcgccagc gtatcagcaa 3202621 gcaaaaacag gaatgagccg atgaaggcgg agaccggtat cagcgtctgg tgacgtggac 3202681 cggtcagcct tctagccaca tgcggcgcga tcaatccgag aaacgcaatg ccccccgcag 3202741 ctgccacgca tgaagcggca agagtgaccg ctgccagaag aagaatccgt ctttcctttt 3202801 caacagcggt gcccagcccg gtcgccaatt ggtctccgag ctgcataatg ttcaaatagc 3202861 gtgccttata taaagtaaac agaagcaaga tcacaatcca agggagaatc gcccagatca 3202921 tattccagtt cgccccccat attgagccgg atatccaaac cgcggcttgc ataaaatcat 3202981 gagggtccat cttgagctga aaaatcagca acagggcgtt gaatccggca ttcaccccta 3203041 tgccgactaa aatcagccga atcggtgtca cgcctttttt ccatgccaga atataaatga 3203101 gaaacgcagc gaggattgct cctgccaaag cactgaacgg cagcataaat gttccgaaaa 3203161 agctaagatc tgaagctgac ccttgaaaaa agtatataaa aagcactaca gcaagtgaac 3203221 cgccggcgtt aattccgaga ataccaggct cggcaagttc attttgagac acgctttgca 3203281 aaatggctcc agctacggag atccctgctc caacaagcaa agaaaggatg atccggggca 3203341 gcctgaactc aaataagaca agttcatcac gcgccgttcc ttggccgaaa aagacctgaa 3203401 gcgttttaag cggtgcaatt ttgataacgc ccaaattgag actgataaaa aagaccacca 3203461 cgataagcaa aaaggtcaca gccattacaa tgagcggttt gtttgttttt gttttcatta 3203521 cagccctctc ctttcacgac gtgccaaata aaagaaaaag ggaacgccga taagagaagt 3203581 cagcgcgccg acaggcgttt caaagggcgc atttacgagt ctggccgcta tgtcagcaaa 3203641 aacaagcaaa acagcaccga gcaccgccga gcaaggaatg atccaccgat aatccacacc 3203701 gaccaaaaaa cgggtaatat gcggaatgat cagcccgata aatgcaatgg tgccggcaat 3203761 ggaaaccgca gctccggtca gaattactac aataagcatg ccaaccagtt tcaccgctga 3203821 tgtatattgt ccaagccctt ttgccagatc gtcaccgaga cttaacactg taacagaccg 3203881 ggcgatgaaa aacgcgagcg ttaaaccgac agcccctgca ataagcaaaa gctggacccc 3203941 cgaccatttc acacccgcta ccccgcctgc gtaccaaaag ctgatatcct gagcgacatc 3204001 aaagcggatt gcaatggcag ttgaaatgcc ggtaaagaaa taagtaactg ccgtacccgc 3204061 cagagcaagc tttacaggcg taagtccgcc ccttgaaaac atgcctatgc ccattaccgt 3204121 cgatgccccc agccccgctc ccgcaaagga ccatagcaca agccccattg cagaaagtcc 3204181 gggaaaaaag gcaaacgcaa tcgaaaccgc aaacgcagag cctgatgtca cacccataat 3204241 cgaaggctct gccaaagggt ttctcgtcat cccctgcatg attgctcccg acactgccaa 3204301 caatgcgcct acaagcgcgg cagccgccgt tctcggaagc cgaagatcat gtataatttg 3204361 gtgagatgtc tttgtcggct gataatgaaa aatggcctcc catacagtgc gcaaatgaat 3204421 atccgctgca cctagggata tggataaaaa tgcgccaagg caaagcaggc atagacctgc 3204481 gataaggacg atgaccgcgc catatgtcct tgacgtccat tggatttctt ctgatgcagt 3204541 ccgtatattt ttatgttgac tcaactgccg tacttccttt ctgttactga taatgattat 3204601 caattgctgt ttcagtatat cacttttttc agctgattta atagagtgtt ttgaacaaaa 3204661 atgaaaatgc atttgcaaaa atatcgtgtc aaccggcact tgcagtggta taatcacaga 3204721 tgataatgat tctctttttc atctatcttt tagaaagaag gtatgagata tgacccatat 3204781 atacaagaaa ctcggagccg cgttttttgc cctgttattg attgcagcgc tggcagcctg 3204841 cgggaataac tcagaaagca aaggttctgc ctctgattca aaaggcgcag aaacctttac 3204901 atacaaggct gaaaacggaa atgtaaaaat cccgaagcat cctaaacggg tggttgtcat 3204961 ggcagacggc tattacggct acttcaaaac actcggcatc aacgttgtag gtgcgcctga 3205021 gaatgtattt aaaaaccctt actacaaagg aaaaaccaac ggcgtcgaaa acatcggaga 3205081 cggcacttcg gttgaaaagg tcattgattt gaaccctgac ctgattatcg tctggacaac 3205141 acagggcgct gatattaaaa agcttgaaaa aattgcgccg actgtcgcag taaaatacga 3205201 taagctcgac aacatcgaac agctgaaaga atttgcaaaa atgacgggaa ctgaagataa 3205261 agctgaaaaa tggctggcca agtgggataa aaaagttgcg gccgctaaaa caaaaatcaa 3205321 aaaagcggtc ggtgacaaaa ccatttccat tatgcaaacg aacggaaaag acatttacgt 3205381 atttggtaaa gactttggaa gaggcggaag catcatttac aaagacctcg gcctgcaggc 3205441 tacaaagctg acaaaagaaa aagccattga ccaggggcca ggttatacaa gtatttcatt 3205501 agagaagctc cctgacttcg ccggagatta cattttcgcg ggcccatggc aatcaggcgg 3205561 tgatgatggc ggcgtttttg aaagctccat ttggaagaac ctgaatgccg ttaaaaatgg 3205621 ccatgtatac aagatggatc cgatcggatt ctatttcaca gacccgattt cattagaagg 3205681 acaactggag tttattacgg aaagcttgac taaataaaca aaagagccgc ctgcccgcgg 3205741 ctcttttgct tatttataag gaacggctca atttgaatca tatcggatat tttctttgag 3205801 ccattcatat taagctgcat cctcatcacg atcagttttt ttatgctgga gagactgaaa 3205861 aacgtttttt gcatatttaa cgaacggatt cctaacagga gaaattgtga ttttataaaa 3205921 aagacacctg agcaaatcag gtgtcttttc attatgcttg tttttctttc tggaacttgt 3205981 tactcacaaa tggataaacg attaagccga caaagaataa accgatgccg agtataaatg 3206041 tcgttaaatc tgctgtgcct gttacgataa caaacacgga gtatgcacac gccagtatcg 3206101 cgatcaatcc gtctcttaca cgggagcctt tcagctggtc atacgtttca cctttgatga 3206161 ctaccttcaa gctgtagatt gcagatacca gatacggaat taaatatgcg agtgtagccg 3206221 ctgtcgttaa aaatgtaaat gcgtcactta ttgtccggga aataaccgag aaaatgaaga 3206281 cctgtgacat gacgtttgta ataatgagtg caatgaccgg acttcccttt ttattcgttt 3206341 ttgcaaaaaa tgccgggaaa tctcctgctt tagcggcttg gtatggcacc tcagagccaa 3206401 gcaaaatcca gccgagcatc gttccgaata aacaaaggat agccaaaagc gccataatca 3206461 cgcttcccgc gtttccaaca atcgcataga gtacatcaac aaatggtttt tcagagccga 3206521 caagcttatc atgcggcaga acacccatcg taattaaagt cacaataata tatatgctca 3206581 aggcaatcag caagccggta attgtcgcac gtttcacatc acgctgagag cgcgcacggc 3206641 cggacaggat caccgcggat tcaattccga caaacgccca cagtgtagaa atcgcagcgt 3206701 tatgaacctg gccaccaatt ccaatgcttg tgccgttttc tccttgaacc gggaaataaa 3206761 aatgaccgaa taatgacgtt tgaaacacaa acaaaccggc aacgataaag aagacaaaac 3206821 ctaatacttt agaaagcgtt gtgacaaagt ttaatttact tgcgccgtta atgctggcaa 3206881 caagaatcgc gtgcgttccc cataacaaga tcgtacatac ggcaaacgtc agtaattggc 3206941 cgagtgtcac ctcttgcccg ccgatcgaaa acatctcacg tttatcaacc aagatcggga 3207001 agaacgaagt caagtaaccg gcgagacttg tgatgatcgc cacgttactg atccagctcg 3207061 ccacccagta gccccacacc attgtgaaac cggcagcgtt gccttttttc gggtcagaaa 3207121 acagcgctct tgcataactt tgcggtcccg ctgtcagttc aggcttgcga atggacaagt 3207181 gtccgaacac aagtgcaatc atcagcacgc cggcacctgt caaaagccag gcggacgtag 3207241 ctccaaacgg actcgcaatt gaagcaagcg agctcggcaa ggagaaaatt cctgatccaa 3207301 ccatatttcc aacgacaaac gccgttaata accaaaaacc ccattttttt gtctgttcca 3207361 ttccagtacc tccatgattc tttgtacgga ccagaccccg agatcatata aacgcaaaaa 3207421 aagcctgaac aaaagtccat gcttaaagaa acacacaccc ttgatctccg gatagccctc 3207481 cgcgaaaaag cacgcggcag tcctgcactt attcagatac agtcccagca tagagaagga 3207541 tcggctttct ccacacttcg gcgctgatgc cttttacaca tgtttaacag cccctgtcag 3207601 cctagcatgt gtgactcatc atccgcgcaa cctctacctc actgagaaag agtgaggatt 3207661 taattattca gttactccca gaaggttatc aaagaaagga tgatctgtca aagggaacag 3207721 atggaaaata cggatagagc caagccctat ccgcatgtgg ttatcgatta tttttctttt 3207781 tttgcacagc ttcttgaagc ggatcatctt ttagagctga accagcatct tcaagagctc 3207841 cttggattac gtttttttct ttttcggaac gttttccttt atctttatta aagaaaccca 3207901 ttcgtatcac ctcttttaaa aaataggtac atgtttaaga tgcctttttc ctgaaaaatt 3207961 atgcgggata ttttttatcg tccaaagtcc tgttgatcaa acatacattc tcttgatata 3208021 tttgtaattc agagattttt tgcaaaagat aaaaggagaa gcggcaaatg acaggaaaaa 3208081 cacacatcat gggaggcatc gcttcttgta cggcagcggc ttattattat ggatttgatc 3208141 cagtgcttat ggctgcgtca ggcgcggttg gagcattaat acccgatatc tgccacacac 3208201 aaagcaaaat cgggagaaaa tttcctattt tatcgaaagt ggtcagctcc gtttttggcc 3208261 atcgcacctt tacacacagc ctgctgttta tgctcatcat gttttttatc acttctacat 3208321 acattccaga taaaaacata tcagccggcc tgatgatcgg aatggcgagc cacttgattc 3208381 ttgacgcttg gacggtgaac ggaatcaaat tattattccc ttccacgatc cgcgttcggc 3208441 ttccattata tatgaagaca ggcagttttt ctgagcagct cgtgctagcc ggcctgaccc 3208501 ttgcttcatg ttactacttt tatatgctgt ttcatggccg catgttttaa acatgagtgc 3208561 tgagacttgt ctgaaccggc tgtttttagt aggttttact taagaagcat ttcatgcaga 3208621 tgatcaagaa aacgtgagga gtcatattga tgaaaggaac cttttttcac aatcagcggt 3208681 ttttatgttt ttcgatctta tttatgtgga tcaaaacgta tgtgatatat aaactcggct 3208741 ttgatttgca aatcgatact ctgttggagg agctaatgct gctggtcaac ccgctcagct 3208801 ttattcttcc tttattcggg atcggcctgt ttctaaaaga aaacaagcag cgggcctttt 3208861 tgctgattgc caatttggtt ctgactgtta tcttgatctc taatacgatt ttttacggct 3208921 tttatatcga ttttattacc atcccggttt tatttcaggc cagcaacatg agcgatatgg 3208981 gcagcagtgt aaaagaactg ttccatcctc tgtttatcgc cctgtttgtg gatttggttt 3209041 ttctgctgtt gttcgccaga aaaaccaaac acccacagac aaaagccgct ccccacacga 3209101 tcaaacggta ctatgcagct tcctgcggaa tgcttttatg cacactggca cttgcagaag 3209161 tacagcagcc gaagcttttg gcacattctt ttgaccggga aatgctagtc aaaagcatcg 3209221 gcctgtttca gttccatatt tacgatacaa tttctcagac tgttaatatc agcgcgaaag 3209281 cttttgccga tgaagacagt ataactgcca ttaaaaacta cacagaggct gattacagca 3209341 agcctgatca aagcaaattc ggtcttgcaa aggggcgcaa tgtcatcttt gtaacacttg 3209401 agtcgaccca aagctttgtt ctgaatgaaa aagtaaatgg aaaagaaatt accccattta 3209461 tgaatgatct cataaaaaaa agctattcct ttgatcattt ctatcagcaa acagaacaag 3209521 gcaaaacatc agattcagaa tttatcgtcg ctaactcact gtatccctcc cttagcggcg 3209581 ccgtcttttt cacgaaaagc gaccatcaat ttcatacgat gtataaatcg ctgaagcagc 3209641 acgattatta ttcagccgtc tttcacgcta accataaaac attttggaac agagatgtca 3209701 tgtacgatac atttggcatt gaccgctttt ttgatgttga tgattttcat gtcactcccg 3209761 ggacatcgac aagctggggc ttaaaagaca aagaattttt agagcagtcc gccaaaaagc 3209821 tgaaaagcct accgcagccg ttctacagca gttttatcac gttaacgaat cattttccgt 3209881 ttgagattga tgaaaaggat cagctgatag atgaattcga ttcaagcagt gatctgttaa 3209941 accgctatgt gaccacggtt cgctatgagg atgaagcatt gaagcatttt atcaaaaaac 3210001 tgaaggacga aggcttatac gaaaattcga tgatcgtatt tatgggagat cattacggca 3210061 tttctgaagc ccataacgag gcaatggctg agtttttagg gaaagacgaa atcacaccgt 3210121 atgacaacgt tcagctccag cgggtgccgt ttatcataca tatcccggga atcaccgatc 3210181 aacagccgga aaccatccct gatgccgggg gacaggtcga cgtcaggccg acgctgatgc 3210241 atttgctcgg cgttgagaca aaaggcgata tccaattcgg caatgatttg ctgtcgggcg 3210301 accgcacccc attcgccgtt ctgcgaaacg gcagctttat tacgaacgat tatgtataca 3210361 caaagaacac gtgctatagc caaaaaacag gtgaagtgct ggaagatcag gatgcgtgcc 3210421 tcccttacaa ggagaaagca aacgaagaac tgtctctctc tgataaaatt ttaaatggtg 3210481 acctgctcag gttttccgaa tgaaaaaatc cctctatcaa gagggatttt ttacgtttcc 3210541 aatatcacct tgccagtcag cttcgtttca tagccgttta aatgagacag attcgccttg 3210601 tagtcctcag aattcaaaat ctccttcacg gctttgagca actgctcatt ttttttcaaa 3210661 acaacgatat catattgttc gtcgatgagc gggataaaat caacactgcc catatgtgcc 3210721 gcgtgctgtg ccccgattcc cgcgtcagcc tgtccgcttg aaacttgtga agcggcagcg 3210781 taatgatcag tcacgatatc gccatatccc actacatcag ccggattcac accaagcaag 3210841 ccaagctgtt catcaaggag cacccttgcg ccagaaccct tttccctgtt gatgatccgg 3210901 atatcggctc ttttcaagtc tttccagcct tgaatgtttt tcggattccc tttttgcaca 3210961 tacagtcctg ctttgcggag aacgacattg atgagacaaa acggttcacc tgtcaaaatc 3211021 cgttttacat aaggcgcgtt atactggccc gtttctgcat cgtacaaatg gaggctgaca 3211081 atgtcacact tgccttgata catatcaatc aggctgttta agcttccttt gtatttacgg 3211141 agcggcgtct cctgaatggc attctccaaa tgcttgctga ggatatccat cgaaatgtcc 3211201 tgtccgctga tcatgacatt tggtctgccg tccggctcag cctcctgcac ctgtttcggc 3211261 gcttcttttg cagcgatggg ctgagacatt ctcatattcg ttttatattg ctttaaatct 3211321 tcttcatcca cacgcatctg ccttccgaca cggtaagcag gcagcacgcc ttttttaatc 3211381 aagtcataaa cggtcagctt tgataccttc agcagacctg caacttcttc tatcgtatag 3211441 gaagaggttt cattcatcat catcactctc ctattttatt ataccttttc gccgaatgta 3211501 aaaaaaccca cataaaccaa acataatcag ttataattag ttatatctaa tgataagggg 3211561 tgcaatcatg tttaagaagt attctatttt catcgcagcc ttaactgctt ttctgcttgt 3211621 agcaggctgt tcttcaaacc agtcttcaac ggacagcgag aaaaaagtaa cgttaaccat 3211681 ctcagctgcc gccagcgcgc aggatgcact tgaggaaatc caaaaaaatt atgaaaaaga 3211741 tcatcaacat ataaccatcc aagataacta tggctcatcc ggcgccttgc aaaaacagat 3211801 ttctcaagga gcaggagcag atctgttctt ctcagctgct gaggataaat ttaaaaagct 3211861 ggtggatgat ggagatatcg caaaaaaaga cagcactgaa ttagtcggta atgaaattgt 3211921 gctggtcgta ccgaaaaacg gagattcacc tgtgacaagc ttcagcaatc tggctgaatc 3211981 agaaaaaatc gctcttggca ctccggaatc cgtaccggca ggagcttatg ggaaagaatc 3212041 actgacaaag ctgtctttat gggacaaagt gaaggataaa attgtgtatg gaaaagacgt 3212101 tcgccaagtt ctttcttatg ttgaaaccgg caatgtagac gcaggtgttg tttataaaac 3212161 agatgcccta gtctcgaaaa aggtcaacat tgttgacgag gcaaaagcag atacacacag 3212221 cccaattgtc tatccgttag gaatcgtaaa agatacaaaa caccgtaagg aagcgaagga 3212281 attttacgaa tacctgcaat ctgatgaagc aatgaaagta tttgagaaat atggctttac 3212341 tgccgagtag cataagcgct tcagaatttt tcacacccgt tgtgctttcc tttcaggtgg 3212401 cggcagttgc cggaattgtt gtcattattc tcggaacact tgctggagca tggatgtcac 3212461 gggcatcatt tttcggaaaa acggcactcg aaacatgttt tatgcttccg ctcgttcttc 3212521 cgcctactgt tgtcggtttt attctgatcg tcattttcgg aaagcacagc ttcatcggac 3212581 aagccatcga gtggattttc cagcagcctg tcattttcac ctggtgggcc gctgtgatcg 3212641 cctcggctgt tgtagccttt ccgcttatgt atcaatcagc caaaaccgga tttgctgaca 3212701 ttgatcccga tatacaaggt gcggcaatgg tagacggcgc tagcagatgg aaagtgttta 3212761 tccatatctc cgtcccgctt gcctatcctt cgttactgac cggaagcatc cttagccttg 3212821 cgcgggcgct cggagaattt ggcgcaacac tcatgtttgc aggaaacatc cccggtgtta 3212881 cgcaaacact gccgacggcg atatatgtcg cattggattc cggcaacaat acccttgctt 3212941 gggcgtgggt cgtctgtatt gttgtcattt cctttttgat gctgtttttc attcaacaga 3213001 aaaaaacgca ctaaaaaaac tccccataac ggggagtttt ttgattaaaa cagaagctca 3213061 tcaggatttg gaccgacacg ctcatcttta tttaatgcgt caattttgtc catgtcttct 3213121 tgagacaatt cgaaatcaaa aatatcagcg ttttcgatga tacggtgttc tttaatggat 3213181 tttggaatgg ttacaactcc atgctgcaga tcccagcgca aaatcacttg agccacagat 3213241 ttattgtgtt tttcagcaat ctgtgtcagt acttcgttat ccaaaagctg tccctgcatg 3213301 agcggagacc acgcttccag ctgaatgcct tgccctttgc agtaatctct taattctttt 3213361 tgcgtcaagc gagggtgaaa ttcaacttgg ttcaccatcg gtttgatttc agcatctttc 3213421 aacagctctt ctaaatgatg aacttggaaa ttgctgacgc cgatcgcgcg aattttgccg 3213481 tctttgtaca gcttttcaag cgcgcgccat gtatctttat atttatcttt gccaggccaa 3213541 tggatcaaat ataaatctaa gtaatcaagc tgcagtcttt ctaggctttt ttcaaaggca 3213601 gcaagcgttg tttcatagcc ttgatcttca ttccacactt ttgatgtgat gaagagctct 3213661 tctcttgcca caccggattc tttaatcccg atgccaacgc cttcttcatt tttgtagatc 3213721 gctgctgtat caatactgcg atagccattt ttaattgccg ctttcactga ttcagtcgct 3213781 tcattaccat tttctacttt aaaaacgccc agaccgaacc aaggcatttc aactccgtta 3213841 tgtaacttta cagtatcttt taaacttgtt ggcacttgaa cctccaccct ttcactgaaa 3213901 tgtaagcgtc tatattatct cacattcctc tcagccgata ccaataatac gcttaagacc 3213961 ctctttttgc ttcttttttc acagcacagg caaatccaaa cactattttt ttcctatttt 3214021 aacaatattg agattacaaa tacattgagc agggtatgcg tgtagtgtaa ccaaatgaaa 3214081 acaaaggagg aaacaacttg aaacgtattc gtatcccaat gacacttgct cttggtgccg 3214141 ctttgacaat tgcccctttg tcctttgctt ccgctgaaga aaatcctgct ccgaagatgt 3214201 cgcagacaac tactgctgga acaactgccg ctgatgtagg tttaaacgtc aacctggatg 3214261 tacttggaat tgccaaccag atcgctgatg ccatcaaatc cgcacagaat agggatggct 3214321 ttgtgaaaaa cctcatggag tcttccttct acgcgtccgg ccaaaaatat aacgtcatgg 3214381 tctttaattt aagccaggaa tatgaagatc atttgaacgg tgtgcaattt tacggctcag 3214441 ccgtttacga cggcattacg tatggcattt gggtatttga agatggaacc tttacaaaca 3214501 aaggcgatgg cggctggatc aactgggcct tcagaggctg gttcgaccgg gatggcagca 3214561 ctgtcgcatt tcatcgccct taatataaaa aaagctggcg ctctaacgcc agcttttttt 3214621 ctgcatttat tcgccgcctt caagcatggc ggcttcgaca tcattaatgt attggcgaag 3214681 ctcatgggag atgtcccggg aaatttccct ctcttcgaag agcgtttgaa tttcatttct 3214741 gatcgcctgc acagccttca gcttcacttc cagcttctga ttttcaaaat gggcacttga 3214801 ttttaactca tgatggctgt gctccagcct gaaaattaac tgcttataga atgtaatgac 3214861 agataaaaac acttctttat gctcatccgt cttatgtttt tccagatatt ctatcgctgc 3214921 ttttgccgtt ttcactcttg ttgcccgtat caatcccgct tcatttaaaa tcgacatctc 3214981 cggcttttta tgttcaccga agaaaatcca atacatcagc ctcttgagcc ttgtttttga 3215041 taacccgact ttaaacgggt tggcatacaa aatttccaac tcgttaaatc gttcttgcag 3215101 cacatttgct gtttcttccg ggatgtctcc ccgctccagc attttcatca gcgcctcttg 3215161 ctcagcctta accccctgcg cacggacttt tcgctcgtgc ttcttaatgc gattagatga 3215221 tgtatactgc tgaaaacgaa gatttttcat tttctcattg tattcagcta tcaccgcaag 3215281 agaggccgtt ttgtttgtct cattcatgtc ctctttaatc gtttgaaggg ctgttttgat 3215341 caacttgcgt ctcgccgtca gcagcttctt atttcgttcc tcgtcctctt cttctttttc 3215401 agtcagaatt ggcagcacaa cggtggcaat gacaagcgtg cataaaatga cgccggctgc 3215461 taaaaagaga atcagatttc tttccggaaa cggcgtaccg tcctccagga aatacggaat 3215521 ggaaaaagaa cctgcaagcg ttactgctcc acgcacaccg gaaatcgaaa ttaacagcgt 3215581 cgaacgaaga cccggtttat agatgttctg atctttatta aagaaccatt tgccgttcca 3215641 gaagaacagc acccacagga atctaaggag cattaatgta aatgtgatga ctaggatata 3215701 gccgatcacc ttcatgttgc tgatggcagt gtcgttaaag ataacagaaa taacatcagg 3215761 gatttgcgtg ccgagaataa cgaagaccag gccgttcaaa ataaataaaa taatgttcca 3215821 cgtacttgag gagacgattt gcagcttgat catcgttgat tccagacgat cctgttcaac 3215881 cgcatgggta ataccgccag ctacaacagc taaaatgccc gaaacgccga tttcttcagc 3215941 tgccaaataa atcacaaacg gcgtcagaat ttgaatcagc atatgcatcg tgacatcctg 3216001 catgccaagg cggcgcagaa ataggcgaaa acgaataatc aaaaatgaaa tgacaacccc 3216061 gcacagcaag cctccgagag aaataaagac aaagctgaca gccgcttgtg ctaatgaaaa 3216121 tgcaccagtc actgccgctg caatcgcaaa cttaaaggcc accagacctg atgcatcatt 3216181 catcagcccc tcaccttcca gcaggcgaag aatccctttt ggcattttca ctcttcctga 3216241 taatgcgctg acagcgacga catcagtcgg tgaaagaatg gccgcaagtc caaaggccgc 3216301 tgccagcgga atagcaggaa tcatccagtg aatcgtgtag ccgcctacaa tcacagtcgc 3216361 aaatacaagg ccgagtgcaa gcaataaaat cggagccctt aaattccaaa gctctgcccg 3216421 cggtgtcctc tttccatcat taaatagcag aggcgcgata aaaagaacaa aaaacaattc 3216481 ggtgtttaat tcaaaatgaa gtccctgtgg aaatgaggcg gcaagaatcc caagagccac 3216541 ttgaatcagc ggcaccggaa taaacggaat aaaccggttc acgatattag aaatcgcaat 3216601 aatcgttaat aatacgagca caactaaaaa tatgtccaaa tgcatgacct ccttcgtctg 3216661 ttgtgtgtcg gcatgatgag ccaaaaaatc tgtttgtcta aaagcccttg agctagggtg 3216721 gccttgcatc cgctatgtgg tttcgcagga gttctctcca cacttgtctt cttttatagt 3216781 acccttttta gggtattttt tctcatgata tgctcacagt gaactttttt gcagaagagc 3216841 aaattataga aaaaagagac aggaagctac tccctgtctc tcgtctttct ttctcaatca 3216901 tgaaaattcg taccgtcagt tgttgcttta ataatgcccg cgcgaatgac aaagtcaccg 3216961 aaatgctcgc cttcctcgcg ttctttcgca tagcgggaaa gaaggatgcg cagctcgctt 3217021 aaaatgtctg cttcaccgat gttttcacgg tacattttgc ttaaacggct tccgtcaaac 3217081 gcagcgccaa gatacatatt atatttgccc ggcgcctttc cgataaatcc gatctcaccg 3217141 agtgcatgac gtgcacagcc gttcgggcat cctgtcatgc gaatggtgat ttcctgatca 3217201 cgaaggccgt tttcgtcaat aatctcttca atcttatcta acagggtcgg caaataacgt 3217261 tctgcttcag ccattgccaa tccgcaggtc ggaagagcga cgcacgccat cgagctgcgg 3217321 cgaagcgctg aatagtgctt gccgtcagtt agtccgtact gttcaattaa agcactgatt 3217381 tcttcttttt tatcgcttga aacgttcgca atcattaagt tctgattggc tgtcagccgg 3217441 aactcacctg tatgaacttt ggcgatttcc cgcaagccag tcatcagctt ataatcatcg 3217501 taatccgtta tacggccgcc ttcgacaaac agcgtgaaat gccatttatc ctcgatgcct 3217561 tccacccagc catagcggtc gccgttatga tcgaaatgat acggcttcgc ttcttccagg 3217621 ctccagccga gacggttttc caattcttct tttacgtttt ctaaaccgag gcggtcaact 3217681 gtgtatttga accgcgcatt tttacggaca gaacggttgc cgtaatcacg ctgaatcgta 3217741 atcgtttttt cagcaacgtc atacatttgc tcaggccggc agaaaccgat caccttggct 3217801 aattgcggat atgtcgcagt atcgccatgc gtcattccca taccgccgcc gattgccacg 3217861 ttaaaaccga tcagcttgcc atcctcgaca atcgcaatga atccgagatc ttgtgaaaag 3217921 acgtcaatat cattagacgg cggaacggca ataccgattt taaacttccg cggcagatag 3217981 agcggtccgt acattggctc gacttcttcc tccggcgtgc cggcaactct ttcctcatca 3218041 agccaaattt catgatatgc tctcgtccgc ggcagcagat catcacttaa ttttttagac 3218101 cactcgtata cctctgagtg gatttcagat tgataagggt ttgatgcaca catgacgtta 3218161 cggtttacgt ctccgcaggc tgcgatcgta tccaaaagtg ctgagtggat cgtctgaatg 3218221 gttttcttca tgttccattt cagaattccg tgcatttgga atgtttcacg tgtcgtcaat 3218281 tttaatgtgc cgttcccgta tttctgggac aggtcatcca tgacaagcca ttgttcaggc 3218341 gtcgagacgc cccctggcat acgcacgcgc agcatgaact gatatgcggg ctcaagcttc 3218401 tgcttttggc gttcatttcg gaggtcgcgg tcatcctgca aataactgcc gtggtgtttc 3218461 atcaggcggt tatcatcatc cggaattccc gcactgattc gatcgagcat cacttctttc 3218521 agcgtgccgc gcaaataatc actttctttt ttaatgcgtt caacatcact tggagagccg 3218581 tccggtgctt ttagaatttt ggtcaccatg ttgaaaaact cctttcaagt caaatcaata 3218641 tacatcacgc tgatagcgtt tttgctgctg catatcggca agataagcct ccgcctcttc 3218701 gcggctcata ttgccttctt tttcgataat ttcaagcaat gtgttatgga cgtcatgcgc 3218761 catgtgcttt tcatctccgc aaatgtaaac agccgctcct tcttgaagcc attcaaacaa 3218821 ttctgcgcta tgttcaagca tgcggtgctg cacatatact ttttcttccg tatcacgtga 3218881 gaacgccaca tccatttttg tcagcacacc gtctttgagc caattctgcc actctgtctg 3218941 gtaaaggaaa tccgtgacaa agtgctgatc gccaaagaac atccatgcct ttccttccgc 3219001 tcccgtctcc tcacgctcct gcataaacga acggaaaggt gcgacgcctg tcccagggcc 3219061 caccatgata atcggtgttt cagggtcttt cggaagctta aagttttgat tgtgctgtac 3219121 ataaaccggc agtgtgtctc ccggctgcag tcgttccgcg cacaaaatcg agcagacgcc 3219181 ttttcgttca cggccgtgcg catcgtagcg gactgcgccg attgttaagt gcacttcatc 3219241 cggatttgcg gataaactgc ttgcaatcga ataaaggcgg gcaggcattt ttcgcaaaat 3219301 cgagacaaac tcctgcgcag atacactaaa tgggccatag tcacggacga gatcaagcaa 3219361 atcgcgccct tcaatatagg cttttacatt ctcctcattt cccggggcta aaagctctct 3219421 aagctcatcg ttccctgtca gctgggctgc ctgttcaaga agcggttttg tgagaacggt 3219481 aatctcatag tgagaaatca gcgcttcttt cagcggtcgg acatcacctt gcttattaag 3219541 cgtcacaatt tcttccgggt cccaattcat ttccttaagg agcagctcga caagttccgg 3219601 atcgttttcc ggatagacgc cgaggctgtc accaggctcg taagtcaggc cagatccttc 3219661 aagagacagc tccacatggc gtgtttcttt atttgatcct ctgccgttta aatttaaatt 3219721 ttctaacact tcagcccgaa acgggtttgt tctggaatac gaagactcac cggtttgtga 3219781 cgcagccgcc ggcgcaggcg cggcgcttcc gcccccagct tcatttaatc ctttcaatac 3219841 accctcaagc cattcggctg ccggttcatc atagtcaaga tcgcaatcaa cgcgcggaga 3219901 aatccgtttt ccgccgagtt cttctaagcg ttgatcaaat tctttccctg tctggcagaa 3219961 aaattcgtac gaactgtcac caagcgccaa aacggaaaag cgcaggtctt caagcttagg 3220021 cgcccgtctt ccgtgcagaa attcatgaaa cgacagcgcg ttatcaggcg gctcgccttc 3220081 tccatgcgta ctgacgacga ttaaaagatt ggttaccttc ttcagctgat tcggcttaaa 3220141 atcgctcatg gatgagacgg tcacttgaaa accgctctgt tcaagctgct tgccggcatt 3220201 ttctgcaagc ccctgtgcgt ttcccgtctg tgaaccataa agaacggtca cttcttttga 3220261 aacggccggt gccggtgctt ccgctgacac agctgccgcc ggcgtacccg cagcttcttg 3220321 ggcggaaaca gattgagcgg ataaatatcc gctcagccag attttctggg attcggtcaa 3220381 ggtcggcaga aggcggttaa ggagctctgc ctgctcctga ttaaacggac tgttcattac 3220441 ctgaagttgc aacgtatcca cctcacaaag ttataaactg atcgaaaatt gcatctaatt 3220501 gaactttacc ggaatactag gcttaagtaa aatatattta catgatgata actattaaga 3220561 atcctaatga taaaacggct atgcttcatg taaatagaaa aaagagaagg actcccttct 3220621 cttcattcag caatctgata taagtgaggc ggcacagcgg ttacaaacgg actggcttca 3220681 cctgtataaa ataccgccag catgtgcatc gcacgggtgc acgcagtata taaaagcctg 3220741 cggtcgtgct ctgtatgata gtgttcttca gatgcatcat agacaagcac tgcgtcaaat 3220801 tcaattccct tcgctaaata caccggaatc acgcaaacac ccttttgaaa tggttgattt 3220861 tctttatgaa tcaggcgaac atctgtatat tcactcatgt gggcgtgcgc ctgtatgcat 3220921 tgatgcgcag tcttgcagat gacggctatt gtttcgtgcc cttttttctt gagccggcca 3220981 atttcttgcg cgagcttttg gcaaaggctc tcatgtcctt cagttttgac aacgagcggc 3221041 atttccccgc ttctattaaa cggctcaata tccgctccat cttgaagcat cgctttggta 3221101 aactcgacaa tctgccttgt tgatctgtat gttctcttta aacgaacata ctcagcaggc 3221161 tcatcctcaa agcacgcatc catacgctga tccccgttta tggtatgcgc gtagatggac 3221221 tgattgatat caccgagcac tgtcatgctg gcagccggaa aaatgcttct catgtaagcc 3221281 atctgaaacg gtgaatagtc ctgggcttcg tcaataaata gatgtttgat tttcgtattt 3221341 ttctttctgc cctcaatcag atcctgcata taaagaaacg gtgccgcgtc ctcatagagc 3221401 aatttattat ccgtaaatgc cgaacgggtc agctcaccta tcgcatccat cttctcatgt 3221461 tgaaattttc ctccccagcc agaaaacaat tgcaaataaa gttgtgtaac atcaagaaat 3221521 gcaaggagcc tgactgcctg tttgagcggt ttgaaagctt ttttcacaat gatggcggca 3221581 agcagctgct gctctctttg ataatcgtta aacgtactct cgctgaaccg tttcctttcc 3221641 tgcagttttt tgtacacgtc caagtagtcc tctttgtcaa gcagctcagc ttcatgaaca 3221701 acccaatcct ttcgccgttc ctttttctca agcttgttaa gctcactcag cagccacttc 3221761 gcggtttgct ccatccgatt cggaatggag tgattttgat ccaatgagta aaaataggat 3221821 tgaatttgct cctttgtgat cagcttttgt ccgcggaata taatattttt aaaaatcatc 3221881 ccttcagagg aaagccgtgt gacgtattca ttaatgaatt gctgaaagga taaacccgcc 3221941 ttccatgtga ttcctgcaag ccttgttgga aaatcgcctc cctttgtttc ggtcaggcaa 3222001 tattcgagct gatcaaaggg gctttcacat ttgaacttgc ggccaagacg atgctcgata 3222061 tattcctgaa acgtcgcctg ctccatattc tcttctccta actccggcaa aacagaggag 3222121 acatagctgt taaataagaa gttgggtgaa aacaaaacga tttgtccggc atcaatgaca 3222181 ccgcggtgcc tgtataacaa ataagcgaca cgctgaagcg cagccgatgt tttcccgctg 3222241 ccagccgctc cctgcacgat caggatcttg cttttttcat tacggataat ctgattttgt 3222301 tctttctgaa tcgtagacac gatgtttttc atttgggtat cagagtgatg gcttaatacc 3222361 tcttgcagca tttcatcgcc aatcgtcata tcggtattaa acatcgcctt gagagtgccg 3222421 tttttgatca taaactggcg tttcagcacc atttcccctt ctatcgtttc accgggcacc 3222481 tcgtactccg cttttcctgg ggaataattg tagtacaaac ttgatatcgg cgccctccag 3222541 tcatagatca gaaagtgttc ctccttctca tccaaacagg aagctaaacc gatataaatt 3222601 cgctctgcct gctcctcgcc gttttcaata aaatcaatcc ggccgaaata aggcgatttt 3222661 ttcaattgat gaattcgttt gagctgctga tccatgcgcc gatgattgtg ttcccgatca 3222721 gacagcagct ctgcctgctg cttaatgcta gccatcgttt caatcgcttc atgggcatca 3222781 tcaaaattaa ccttaacatc ctcccaaaag ctttttctta atccgatgat atcatgcttc 3222841 aacccgcccg cagacgtttc cagaaaccgc tctttttttt cgagctcctt cagcacctca 3222901 tctattctcg actgctcttc cttccattcc ttatcctgct gattcatgaa cggcacctcc 3222961 agaaaatagt tgacaaacat agatgaaata ctgtaaaata taattggata catatattaa 3223021 atatatgatg caaactggca aatacaattt ataatagcac attcacccaa taccaatcaa 3223081 ggtttgggtt atttatatta tgcagaaaaa aaccgatttc acttcgaaat cggttttttt 3223141 gctattaatt atctaagcga aaagaacggt ttggcagctt ccaattaaac atataggaac 3223201 aaacccggca aacaacgagc acgaaaaaca gaacgtataa gccgaacgag ttccccagcc 3223261 agcccaagcc gacgattaaa ccgccgagcg ccgcccatac cgcatagatt tccgctttca 3223321 gcacaagcgg tttgcgcccg gcaagaaggt cgcggatgat cccgcccccg cttcccgtca 3223381 gcaccgcagc cacgatcacg gcactaagcg gatggcccat tttgacggca tacagtgcgc 3223441 cttggatagc aaaggcagcg aggccgatcg catctgataa attgccccac ttattccaat 3223501 gcttcagcag cagcttcgga aacagaaaca caattgtaat agataaaagc gcgatttgaa 3223561 agtacgctcc ctgctcccat agcgctgaca ccggaacacc gatcagcaaa ttgcggatcg 3223621 ctcctcctcc aaaagctgtg acaatcccta atatataaac tcctaaaata tcatattcct 3223681 cttccatcgc aacaattgcg ccgctgactg caaacgcaat gatgccaatc acactaagca 3223741 gctcccaagc cattctgatg actccctttt atgtttgtta aattttctga cgacctctag 3223801 attttataat cgctccagcg taaaatcaat aacattttca tgagaaaaaa agataaattt 3223861 agagggaata cggctattgc tgatggacat gagtttgcga aattaaaaaa gcgcccggca 3223921 tacgcgggcg ctttttttgt tattcagatt tttcgccttt cagcaggcac ataaaaatga 3223981 taatcaggat aaaagcaatc agggccagga atggaatcgt aataaaacca aaccagttaa 3224041 tatattggcc cgagcacggc acgccgctga cacatggctt aatgccgcta aagccgggca 3224101 ctttttgctc taagtaatgc atgatcgaaa tgaatgcccc aataatcgcc atcgggagca 3224161 catatttttt cactcgtgtg tccccttgaa aggtggcgat gcctaaaatc aggacgagcg 3224221 gatacatgag gatacgctgg taccagcaca gttcacatgg aataaacttt ctgatttcac 3224281 tgaaatacag gctgcccagc atagcgataa gagccacaac ccaggaagca tataaaaata 3224341 cgattctatt tttcatattg ttacttccct ttcagctctt tttctattgt ctctttgatt 3224401 tcatcataat ccgcaaaatt tttgatcact ttatcattga cgtaaatcgt cggtgttgcc 3224461 tgtatgttca ttttttgatt aaggtcagaa tccttttcca cttgagaagc gaatgtttcc 3224521 ttatcaagat tttccttgag cgtctcaggt tttatctttg tggtgctttt tgcaagatca 3224581 ccaaggaggc ctggggttac ccattcctgt tccgtatccg gctgtttttc gaacagcttt 3224641 tcatggaaat cccagaaaga gtcagggtct tccttccata cttcttcaga tgcaagagcc 3224701 gctaaccttg aaccttttcc atggaacatg acgttcacga aagaaaattt cacatcgccc 3224761 ttatcaataa agtctttttg tatttttgga aagatgtcac tgttaaacac cttgcaagac 3224821 ggacatttgt aatctccgaa ttctactaca gttaccggtg catcgtcctt gccaagcaca 3224881 ggctgccctt tgatagacgg ctgtccggac accgcatcat tgccttgttc cgttttgtta 3224941 ttaatgatga caatggctgc tagcaataca acaaccacaa ccgtaaggat gaccgcgaat 3225001 ttcgcagaag actgctgttt ctttttcact ccgacacctc atcgttttaa aattaaaaaa 3225061 gaagcggatc gcaattgacc cacttcttta ttttaacaag acaagcgctg ataagaaaac 3225121 cccgaaaaaa tgaattctct ccgacaattt atttgttttt gagacgcatg acgcgcatgg 3225181 cgttcgccac agcaagcagt gtaacgccga catctgagaa aaccgcttcc cacatggtcg 3225241 caattccaaa tgcaccaaga atgagaaaga tcgctttcac acctaaagca aagccgatgt 3225301 tttgccacac gattcgccgt gtccgtttcg caatccgaat cgcttctgct atttttgacg 3225361 gctgatctgt catcagcacg atgtctgcgg cttctaccgc ggcgtctgag ccaaggcctc 3225421 ccatcgcaac ccctatatct gcgcgtgcaa gcaccggcgt atcattgatg ccgtcaccga 3225481 caaaaatgag tttttcacta ggcaaaagct tagcttctaa tgcttcgacc tgcgcgactt 3225541 tatcttgcgg cagcagctct gcatatacct caccaatccc aagctgtttt ccgacggctt 3225601 ctcccgtttg tttcgaatca cccgtcagca tagctgtctg tttgatccca agcgacttca 3225661 gatcagcaac cgcctgtgct gcgtcttcct ttatctcatc cgctatgatg attgctccgg 3225721 catagcgttg atctacagca acgtgtacga ttgttccagc attttcatcc gggacatcct 3225781 caatttgttc tctttccatg agctttttat tcccagcaag gatctcagtt ccatttacct 3225841 ttgcaaaaat gccgtgaccg gagatttctt cgtatgactc aatctcatcg gaggaaagca 3225901 ttttcccgta agctttacgc acagattcag caatcggatg ctgtgaatga agctcagcgt 3225961 atgccgccgc ttcaagtaat ctatcctttg taaaaccttc cgcgggtttg atttctgtca 3226021 cttcaaagct gccttttgtt agtgttcccg ttttatcaaa caccgcgtat ttgacttgat 3226081 tcaaagcttc taaataattg cttcccttta caagcactcc ggcctttgag gccgctccga 3226141 ttccaccgaa gaaaccgagc ggaatagaga caacaagcgc acaaggacaa gaaatcacta 3226201 aaaagataag cgcgcggtac acccaatcgg aaagcgcggc gccagaaaga acaagcggcg 3226261 gaacaaaggc cagcaatacc gcaatgatca ccacagcagg tgtataatac ttggcaaact 3226321 tcgtgataaa gttttctgtc cgggctttac ggctgctcgc attctgaacc aagtctaata 3226381 tttttgatac tgctgattcc tgatagccct ttgtgacttc aatatgcaga acgccgtttt 3226441 gattgataaa gcctgacatt acatcttgtc cttccgcagc ttttctcgga acggactcac 3226501 ctgttaaagc agatgtatca accatcgctg acccttgcac gaccttaccg tccaggggta 3226561 tgctttctcc cggattaacc acaatgatgt ctcctgtctg aacgtcctcc gacgaaacct 3226621 gttcgatgcc gttctttgtt ttgagattgg cgtaatcagg ccgtatgtcc attaacgcac 3226681 taattgattt tctggaacgg ctgaccgcgg ctccttgaaa aagctcaccg atttgataaa 3226741 acagcataac ggcgaccccc tcagggtatt gctgaatcag aaaagcgccg attgtggcaa 3226801 gagccattaa gaaatgctca tcaaacacct gaccgcggat gatgtttttg actgcgcgga 3226861 ttataatgtc accgccgata atcaaataag caccgaggaa aaggaaaaat tcaatggttc 3226921 ccgactgaac caaatatgcc gctgcgccga gaatgacagc cgccgccatt ctgatcagca 3226981 tattgaccat tcgattacga tagccatcat cagctgattt ctttatatgc ttttggcgaa 3227041 ccgttacatg cggatcaatt gatttcactt ttttctctac tttattcgtg acccattgct 3227101 cttctttccc atcggctgag acagttaagg tgcttgccgc aaaatttacc gcgcatccgt 3227161 taatgccttt tatgcctttg actccatttt cgatttttcg ggcacaattg ctgcaatcca 3227221 aaccgtccag aacatattcc tgtttcacta gtctcacctt accttccgat ttagggttcc 3227281 ctcttcaaag cgtatcaatg agtattgtat ttattttata tatatgagca tatactcata 3227341 tataagttac acctattata tgttgttttc caagaaagtg tcaatgaaaa acaaaaaccg 3227401 gcatatagcc ggtttttcat tttacttttt gcagacgaag agcattcaga acaacggaaa 3227461 cggagctgaa tgccattgct gctcctgcta tccacggtgc taaaaatcca agtgctgcga 3227521 ttgggatgcc gaggctgtta tagccaagcg cccagaataa gttttgttta atgtttttca 3227581 ttgtcaatct gctcatgcgg attgcgtcgg caatgctgtt cagatcgccg cgaataagtg 3227641 taatgtctgc tgtttccatg gcaatgtccg tgccagttcc aatcgccatg ccgatgtcag 3227701 ctgtggcaag cgccggcgca tcgttaattc cgtcgcctac cattgctgtc tggcggcctt 3227761 ctttttgcaa gcgggcgatt tccgccgcct tttgttcagg aagaacttcc gcaatgatat 3227821 tcgcaattcc cgcttccttc gcgatggctt ctgcggttct gcgattgtct cctgtcatca 3227881 tgatgacatc aagacccaac tctttcagac gggcaacagc cttccgcgac gtatccttaa 3227941 tcgtatctgc aactgctact agccccgctg cttctccatc aatggataca agcataactg 3228001 ttttcccttc ggcctctagc tcttccattt gggcgagaag agccccatgc tcaacctgtt 3228061 cgctctccat taattttctt gtgccgacga gaatgctttt tcctccggct tcagccaaaa 3228121 tgcctgcgcc gacttttgct tcaaagcggg taagtttcgg tatctcaagc cctttatctt 3228181 tcacgccagc aataatcgct tcgccaagcg gatgctctga tcccgtttcc gctgccgctg 3228241 caaattgaag caaatctttt tcttcaaaac ggccgaatgg aatggcatcc gtcagacgcg 3228301 gcttcccgtt tgtcacggtt ccggttttat caagaacaat tgtatcgaga cgatgtgttt 3228361 tttctaaatg ctcgccgcct ttaaataaaa tcccgaattc agcagcgcgt ccagatccag 3228421 ccattatgct cgtcggagtg gcaagaccga gggcgcaagg acaggcaatg acaagaaccg 3228481 caatgaactt gctgatcgct tcggcaaaat cgccaggagc cgcccaaaga taccaaatga 3228541 gaaaagtgag aaccgcaatc cccaatacaa tgggtacaaa aatgcctgaa atctggtcag 3228601 cgagacgctg gatcggcgct tttgaccctt gtgcttcctc aacaattttg atgatatgag 3228661 aaagcgcagt atcctttccg acgttgacag ctttaatttt cagaaagccg tttgcgttaa 3228721 cggttgaacc tgtcacgctg tcaccaggat ttttgtcaac aggaagactt tctcctgtaa 3228781 tcatcgattc gtcaaccgct gaacggcctt caaccacttc tccgtcgaca ggaattcgtt 3228841 cgccaggttt gacgtaaaca atgtcattaa caagcacttc gtcgatcggg atgatttgct 3228901 cctgtccgtc tcttacaaca gtagctgttt tcgcttgaag cttcatcagc tttttaatcg 3228961 catccgagga acggcctttt gcttttgttt caaacaactt gcctaataaa atcagcgtca 3229021 gcaaaatcgc gcttgtttca taataaaggc cgtctgtatg cccgtgagag ccaatgcttt 3229081 gaaaagttag ataaagacta taagcgtaag cagccgtcgt accgagggcg accaatacat 3229141 ccatattggc gcttttattt ctaagcgcct tatacgcacc cacataaaac ggccagccga 3229201 tcagaaactg gactggtgtc gccagcgcaa actgcatcca cggattgaga aatatatccg 3229261 gtacccaaat gaatgatgta aatgtaaaat ggctcaccat cgcccaaagc aatggaaatg 3229321 acaggacagc tgaaaaaatc agtctcgccg tttgcttccg ttcttctttc tttttagcag 3229381 cagcctcact gtcctgttca cccttcaact ttagcttata tccaagctta tctaccgctt 3229441 ctttcaaatc gctgacagac gcttcttttg gattgtattc gaccgtaact gtttctaaag 3229501 cgaagtttac tggtgcattt gcgacgcctt ctattttgtt aagccgtttt tcaatccgat 3229561 tggcgcaagc cgcacaggtc atgccctcaa tatcgaattc agctttttct gtaacgacgt 3229621 gatagcccag cttctctatt ttttcctgaa tcgctgcagt ccctgtttca gcaggatcgt 3229681 agattacatt tgatgtttcc gttgccagat taacatttgc atccgtgaca ccgggcatcc 3229741 gcttcaggcc tttttcaatt ctggcagcac atgccgcaca ggtcatacca gagacctgca 3229801 tcgcgatttc cttttgttca ctcaacatac tcactccttt atatacacct ggggggtata 3229861 taaaaatgaa agaaatatcg cgcctcccta aaggcgcgat accttgaatc acttggctac 3229921 gtcatagccc tgatcttcta tcgcatccgc aatatctttg actgatactt tgtcagcatc 3229981 aaacgaaaca tcgactttac ccgcttccag attgacatga acggcactga cgccgtccag 3230041 ttctcctacg cttgtttcta ctgctttgac gcagtgctga caagacattc cttcaacttg 3230101 caatgttttt tgttccatat caattcctcc tgtttattct ttctattttc atcctaccat 3230161 acccccgtag ggtattacaa taaaaaacgc tttatgattt tgtgaacttt ttaaatacgt 3230221 ccaaaagctc agaaatggcc tgttccccgt ctccgctttt gatggcatct gctacacaat 3230281 gatgggcatg atcctcaagc aaatgaagcg ccacattttt cattgccgcc tgaacagctg 3230341 aaatttgcac aagaatatct acacaatatc tgtcgttttc caccatgttt tgaatgcctc 3230401 tgacctggcc ctcaatccgc ttaagccggt ttgtaatctg atccttttct ttcgagcttt 3230461 tatggtttaa tgttttatgt tcgttatgct tttccatgcg tacacctctg tttaatgata 3230521 ttaattccca ttatactgat tgtccaaacg gttgtctaag catgccgacg caaaaaatga 3230581 atcagttagg ttttaccatt tgatcaggag ggtatatact tctgttgata acgcttttaa 3230641 aggggagaag aaaagtggat acgatcaagg ttggaatatt aggatacgga ttgtccggtt 3230701 ctgtttttca cgggccgctg ctggatgttc tggatgaata tcaaatcagc aaaatcatga 3230761 catcacggac agaagaagtg aaacgggatt ttccagatgc tgaggttgta catgagcttg 3230821 aagaaatcac aaatgaccct gccattgagc ttgtcattgt caccaccccg agcggccttc 3230881 attacgagca tactatggca tgcatacagg ccggaaaaca tgttgtgatg gaaaaaccaa 3230941 tgacagcaac ggccgaagag ggggaaacat taaaaagggc tgccgatgaa aaaggcgtat 3231001 tattaagcgt atatcataac cgacgctggg ataacgattt tttaacgatt aaaaagctga 3231061 tctctgaggg atcccttgaa gatatcaata catatcaagt ttcctataac cgctacagac 3231121 ctgaagttca agcgcggtgg cgggaaaaag aaggcactgc cactggtacg ctgtatgatc 3231181 tcggctccca catcatagac caaaccctgc atttgtttgg gatgcctaaa gccgtgactg 3231241 caaacgtgat ggcccagcgg gaaaatgccg aaacggttga ctattttcat ttaaccctgg 3231301 attatggcaa gcttcaagcc attctatacg gaggatcaat cgttccggca aacggacctc 3231361 gttatcaaat ccatggaaaa gattctagct ttatcaaata tggaattgac ggacaggaag 3231421 acgcactcag agcgggaaga aaaccagagg atgacagctg gggtgcggat gttccggagt 3231481 tttacggaaa gcttacaacc attcgtggct ccgacaaaaa aacagaaacg attccatcag 3231541 taaatggctc ctaccttact tattaccgta aaatagcgga aagcatacga gaaggtgctg 3231601 cgctgccagt cactgctgag gaaggtatta atgtcatccg catcattgaa gccgcgatgg 3231661 aaagcagtaa agagaaacga accattatgc tggagcacta aaacaaaagc ctccccaaat 3231721 aaggggaggc tttttcatta gaatgttttt cctgcttctt tcgcacgcgc aatcgcgtct 3231781 tctttgattt gctgtgcttt atcaggctcc gcattatgtc cctctacgaa aatgccatcg 3231841 aatgatggta cgccgaagaa gttcatcatg atgccgatgt agcggtgccc catttccatc 3231901 tcagccgcag ggccttctga atagtagccg ccgcgcgctt ggatatgaat tgctttttta 3231961 tcagttaaca agccgacagg accttgttct gtgtatttga atgattttcc tgcaacagca 3232021 acagaatcga gatacgcttt catcactggc gggaatgaga agttccataa aggagtaaca 3232081 aatacgtact tatcagctga tgcaaattga tcgctaagct ctcccaaacg gcctactttc 3232141 gctttttcgc tttcagaaag ctcttcaaag cctgtacctg actgaagctt tccccatccg 3232201 ctaaatacat ctgcgtcaat gtgcggaatg ttttctttgt acaaatcgat atgtacaact 3232261 tcatcatttg gattcgcttc tttgtaagat tcgataaatg ctttacctgt tgccatactg 3232321 tacgaagttg cttcgtcatg tggatgagca gtgatatata atacttttgc catttttacc 3232381 agccctttcg tttttaaaaa tcacacatca attattatca tacagatgca taatgattat 3232441 tctgtctctc ttagacttta ttatagagac aaagaaattt actttcaagt aaaacatctc 3232501 gaattaaaga ttatttaact ttcccaaaca gcttactttt caaaagctgt tctcaagccg 3232561 gaatacagcg cggacaattc tttactgatc cgaggataat gagggacatg cggcacttga 3232621 atatccgcag gcatcctttt catgataaag gattgctcag cctgttcaaa aaacgcccgc 3232681 agctggttga tctcttcatc agaaaacgga gcagacggac ggcggtgagc ttgcgccgag 3232741 agcaaatagt accctaagtg ctgagcaccg gaaatggcag gccagagcgc atccgcattc 3232801 gcgtgaggaa actcgccaag cgccttgtca tacgcatccc gaagcctgac aagactcacc 3232861 cttaacttgt gttcgtcggc aatttgcccg gttaacagtt tctccataaa ctgcccttcc 3232921 agccggatga cattccgcac aagttctggc agccgcttgg ttgaaaaccg ccgccacaaa 3232981 agcattgttc ccaacagccc gatcacgctg ccgacagcta catcagtcag cctcgctatc 3233041 ataaaataac cggcgcccgc cccgccatgc atactttctg tgataacaag cgcatttgcg 3233101 gttaaaaagg gaacagccag cgcataattg cggacgatca gcatctcaag aagacattgc 3233161 agcgctgcaa tacaaaacgc aatataaaca ccgcccggct taaaaaacag gattgcgcct 3233221 gccagtataa caccgatcac cgttccggcc gaacgctgaa tagccctgtg aagcgtaaaa 3233281 acaacagtag tgccaagcat gaccgctgct gccgaaagcg gaatccaata ggagcgtgca 3233341 aagccgaatg cgagggcaaa catatcggcg gcaaacagaa caattccgta ctttaacgct 3233401 ctaatcaaaa ctggagactt ccagtcaaag gcatttctca aaaagtaaaa agaggatggc 3233461 aggcggcttg gttccccgtc aagctgctta tcaaaacgtc ctgaagcgat atacaaaacc 3233521 tcattgattt cttcaaacag cttccgccta ggctcagatt cattttcatt aatctgaaac 3233581 gtattgaaaa cccgtgcatt cgcaagcata tctccggttt ggcgaagtgc cttttcaatc 3233641 tgcgcggtct ctctgtccgg cgtttcagct gaaaaatgaa taatggcaat aaatatgtcg 3233701 tcagctttct caaggaggcg aaaaaatcgt tcatcatgcc gcgatttttt ccgtctgttc 3233761 cctttcccaa gaaccgtttg gcgggctgtt ctaagcatga gcaccgtctg atgctgtgcg 3233821 ttatgaaaac ctggcgttcc gacggctgaa agacatgcag ccagctgatg atatgttttt 3233881 tgcagcaccg ctccctccgg tccatgtttg ttccataacc agccgattaa agcgataccc 3233941 atggcgaaaa tgccgccgag aaacgtcagt cccgctctga acagcgcttg tgaaggatcg 3234001 gccggcagcc cggaactgac taaaaaggca aggacaaaaa acatcggcgc agggccttga 3234061 atgccgagcg cgctaaaaat aaacatcgcc gctgcaccga tcagccccaa aacagccgcc 3234121 atcatccaaa gcatcccgga caaaagcgtc cctaaaccaa atgagagggc gatcccaata 3234181 gaaaccaaga gcagcttcaa ggcgcgcttt ttgtacgatt caccgcccgc atataaataa 3234241 acaaagcctc cgatacttgc aattaatccg taatccgtgt gacctgccaa tgcaccgacc 3234301 agcacaggaa accctgaagc gaaacctgat ccgatagcct ttttccaagg aaatggattt 3234361 gcatgaatgc gaaaggcatc cttcacgata ggcatgattc tttgattgtt cgcagcagtt 3234421 ttgttcattt gacaaaatcc ttttcaatga atgtgtagaa cttttccagt ttcttcgctt 3234481 tagtatgccc aaaaacgcgg ttagcttctc aattggtgcg cacgataaaa aaacagagac 3234541 ttataccgtc tctgcttcat tacatcagtt tattataaaa gcggcacctg tcaggactgt 3234601 tttgtccttc tgccttcctt caagagcagg tgaataaaaa ataaaggata aatcaataga 3234661 tacccattaa acagccacca cacaagatca aagtcactgc tgaatgtcca gaatgatagc 3234721 gcctgcagac ctgaacaaca ggtcagcaca agagaaatca gcgccatcag cttccagtca 3234781 gcacgattca cccgctgtag gtacaagctg tacaaccctg tgacagaaat caggatatcc 3234841 agcggaaaaa aagaccagtt ccaagcgatc ataaacggat ggtcatgatg tttaaaagcc 3234901 cagctttccg gtatgagcga aaatccggct gacagccagt acaagataaa accgatatca 3234961 gtcacgagaa aaaacagctt catatatctc atttgtactg cccgctttta tgtaccggct 3235021 cagacaccgc aacatgctcg atcaggttta aagacacaac accggcaata atcaatccaa 3235081 ttgaaatgac tttcatgaca ctcacatgtt cttgaaaaaa caaaaaacca acgactgtaa 3235141 tcaagacaat tcccatccct gaccatacag cataagcaac tgatacatca atggatttaa 3235201 gcgtaagcgt cagaaagaaa agactccctc cataaaagaa aatcaacagc aaactgggaa 3235261 taagctttgt aaaaccagac gatagcttca tgctgacagt tcccgcaacc tcaaacaaaa 3235321 tcgccaagca tagaaacacc caattcatgt ggcatcagcc tcctcatcag ctgttatacc 3235381 gttaaacaaa acatctacaa ttgattcaag tacctctcct gtcgtgaact gatgtttcag 3235441 cggatattca gggtcataca cttgattgat gctccctata tacatgtgaa caaacaggtc 3235501 cggattgatg tttctgattc tcttttgctg tttgcactca tttaataatg ctaggacaat 3235561 cgcccattct tccttaataa acgcgtctaa tgtaagccac gcatcgtaat ggtatttctt 3235621 tagttcattt aataatccca tgttcagcag ttccatcccc tgcggaaggc tgatcagcat 3235681 ttgtttcacc ttttcgagca catttaaact ttcattttca tagatgtctc tttctatttg 3235741 cttcatttca gctataaatt gttcgacaac cgcctcaaca agctgatctt tagatgaata 3235801 atatgcatag agcgtccgct tgctcgttcc cagcgctgcc gccaaatcat tcatcgtaaa 3235861 tgaaaatcct ttctgcttga tcagccggaa ggtttccgcc agaattcttt tatccatatt 3235921 aatcccccgc tttcggtacc aagaaaacta tttcggtacc aatattatac ggcagaaatt 3235981 tatggaaatc aacaatatat aaaaaaacct ctcctattgg gagaggttta aaagacactg 3236041 cggaccaaac cgccgtccgc ccgaagtgcc gcgccattga tcgcagagga aagcggactg 3236101 cttaaaaatg taacgaagtg ggcgatttct tccggacgga tcagtctttg aataatagat 3236161 gtcggccggt tttctttcat aaaacgtgcc tcagcttctt gaacagtcag gttttcacca 3236221 ggatacagcg agttcagcat ggtttccaca ccctctgtta aggtagagcc cggcatgacg 3236281 gtgttgactg tgacattcgt gccggttgcc agctccgcca aactgcggga aatggacagc 3236341 tgcatcgttt ttgtcgcact gtaatgggcc atttcctgtg acggcataat cgccgcttca 3236401 ctggcaatga aaatcacacg cccttctttt ttctctatca tgttatgcaa atacctgcgt 3236461 gtcagcctta caccgctcat aatattcact tcaaaaaaac gaaaccattc atcgtcggga 3236521 atatcaaagt actccgccgg ttcaaaaatc cctaaattgt tgaccaaaat atcaacctct 3236581 ggatatgcct gaaacagctc attgcagcct tcttctgttc ccaaatcaaa tgcagccgga 3236641 taaagaaccg cttcagcatg ttgtgttttc agttcatcta tcgtttgatt cactttctct 3236701 tcccggcgtc cgttaatgat cactgccgca ccttcttcag ctaacgaaga ggcaatagct 3236761 tttccgatcc ctgatgtcga accggtcacc agtgcggttt ttccttgtaa attcagcttc 3236821 attattcatc cctccgtttt tgattcctct tatttattga cagaaatctg attggtgaaa 3236881 catctgctct gcaatcagta tgaaacagct gggattgaaa tggaagtacg cactttttgg 3236941 tgcctgtggt ttggagaaaa aataaagcag aacctcttaa gaggttctgc tttattgtca 3237001 gtatgtatgg agacggtggg agtcgaaccc acgtccagaa acatcgatta cttaagcgtc 3237061 tacgagcgta gcctgcatat ttatggtttc actcatcttc ttgcctgcgg gcgggccttc 3237121 cgagagctag tctgttcatc tcttcttacg ttctcagacg ggaacgcaag cgtagcctac 3237181 ttggatgtgc tcttcacaga cacataggca atgtcaggaa gagctcgctg cgcttattag 3237241 gcagctaatg ctacgttttg gttaaaactg ttagttttgc cagttatatt taagtgcgtg 3237301 tttacgagat cgcctctcgg ctcgcagctc aagctcgatc catccctgtc gaatccgtaa 3237361 cgtccccttg gtataaggga aatacgggag aaaatatcaa gctctcactc aaactggcta 3237421 tagtcttatt ataacatgat cacggctctt ttcaattgtc aaatccttca aatgaatggc 3237481 gtcgtgatct gatcgtgaac acagtatagc acaggcctga ttttcgaatc aagcactatg 3237541 cctttagaag cctttttgac tgtctctgaa cgctctttcg atttcccgct tcgcgtcctt 3237601 gcgcttcaga tcttcccgtt tgtcatagtt cttcttccct tttccaaggc cgagaagcac 3237661 tttggcaaag ccgtttttta aatacagctt cagcggaacg agagaatagc ctttttcctt 3237721 tgttaacccg atcagcttat taatctcctt gcggtgcatt aacagctttc ttgtccggag 3237781 cggatcgtgg ttatagcggt ttccctgctc atatgggctg acgtgcatat tgtggagaaa 3237841 cacttctccc cgttcgattt tggcgaagga atccttaagg tttacgcggc cggcgcgaat 3237901 cgatttgatt tcggttcctt gcagaacgat gcctgtttca taggtttctt ctataaaata 3237961 atcgtggttg gctttcttat tttgagataa tacttttcct gacccttttg gcatgccaga 3238021 acctcctctc tctaaggaaa aactgtccac cttttgcgat acgctctatt ttaccaaatg 3238081 tcacgtaccg ctacaatgaa aagctgtttc cgaaagaaag caaatagagc gctgcggccc 3238141 tatttgctgg ttgagctgct atttcttctt tttccgtttc tgtttcggag cattctggaa 3238201 gccgcgtttt ttctttttct tcttcggctt agtgaaccac tccccttttt cctcagacgg 3238261 agctggagaa acaggtgtat tggtgctttg aacacgtttt ctggcaggct ttccgcgttt 3238321 tctgctccgg ctgctgtcca attctctcgg acgccgcgga gtgcctttca tgccgacaat 3238381 ttcaaagtcg atattgcgct catctttatt gacatcgaca accttgactg tgatttcatc 3238441 cccgatgcgg aagacgttgc ctgtccgctc gccaatcatt gcgaaatgct gttcgtcaaa 3238501 gcggtagtag tcatctgtca taaagctgac atggacgagt ccttcaattg tattcggcag 3238561 ctcgacgaac attccgaagt ttgtcacaga gctgatcatg ccgtcaaact cttcaccgat 3238621 tttatcaagc atgtattccg cttttttcag atcatccgtc tcacgctcgg cgtcaactgc 3238681 acggcgctcc atagatgatg tatgttcggc gatatccggc aggcgttcag cccacttttc 3238741 ctgtgtcgct tcatcgacct tgccgttgat caaatacgtt cggatcagac ggtgaacgat 3238801 taagtccggg taacggcgga tcggtgatgt gaaatgcgta tagaattccg ttgacagacc 3238861 gaagtgcccc aagctttgcg ggtcgtattt cgcctgtttc atcgaacgga gcataacagt 3238921 agatataacc gtttcctctg gtctgtcacg cacagcgtcc agaatgcttt gcagcgcgcg 3238981 cggatgaata ttccccgccg ttcctttcac cacatagcca aatgtcgtca caaattctaa 3239041 aaacttttgc agcttttcag cattcggctc ttcgtgaatc cggtatataa acgggacatt 3239101 catccaatgg aaatgctccg caactgtttc gtttgctaca agcataaatt cttcaatcag 3239161 cttctcggcg acagagcgtt ctctgatcac aacgtcttta accgctcctt cgtcatcaac 3239221 aagcaccttt gcttctttga aatcaaagtc aacggcgccg cggtccatcc gcttatcgcg 3239281 cagaatttga gccagacgct ccatgtcttt gaacatcgga acaagaggct cgtatttttg 3239341 tttcagctct tcatcatcat caacaagaat tttattcaca tctgaatatg tcattctttc 3239401 cgttgttttg atgacacttt ggaagatctc gtgctctgtc acctgtccct gactgttaat 3239461 tgtcatttca caagaaagcg tcaggcggtc aacctttgga tttaaggagc agatgccgtt 3239521 tgacaatctg tgcggaatca tcgggatgac acggtcaacc agatacacac ttgtccctct 3239581 ttcaagcgct tctttgtcaa tcggcgagtt ttcggttacg taatggctga catcagctat 3239641 gtgaacgcca agcttgtagc ttccatcatc aagcttcgtc acggtaactg catcatccaa 3239701 atccttcgca tccgcaccat caatggtgac aatcacctgg tcacggagat cacggcggtc 3239761 tttcagatct ttttcatcaa tcgtgtcagg cgtacttgat gcctgttcca tcgcgtcagc 3239821 tggaaattct cccggcaggc cgtgcttatg aatgaccgat aaaatatcaa tgcccgggtc 3239881 gtttttgtgg ccgagaatgg tttcaacctc accctctgcg ttcatgcggc cttcaggata 3239941 gctcgtcagc ttgacaacaa ccttatgccc ttccgcagct ccatttttcc catttttcgg 3240001 aatgaagatg tcactcgtga tttttttgtc gtccggaatg acaaagccga agtttctcgt 3240061 ttctgtatac gtgccgacaa cccgctgaat cgctctttct aaaatccgta tgacggttcc 3240121 ttcctgcctg gagccgcttg attgtgagtt cagacgcacc atgacgatat cgccgttcat 3240181 tgccgtattt agctcattag gcggaataaa cacatcactt aacgacgtat cctcaggcag 3240241 caaaaaggcg aatcctttcg catgggctga aatctttcct tttattaaat tcatcttctc 3240301 cggaatgccg tagcggtcgc ttctcgtccg tacgataagc cctttttctt ccaaggcgac 3240361 taacgctttg acgagctctt taaactcctc ggcttccgta atatttaaca tctcctcaag 3240421 ttcctgaacg gtcagaggtt tgtacgcctc ttccttcata aacgagagaa gcttttccat 3240481 aaatgcttct ttttccatta tccgacctcc tgttgattac caatcgagct tctctaaaaa 3240541 ttcatacaca tcctgatgga cgaggtcacg ttctttgtcg agtgtaatga catgccctga 3240601 ttcctcgtac catttcagct gtttatcatc agtttccact tcgttgtaaa taatattggc 3240661 gctttcggta ttaatcatgt ggtcatgacg ggcctgcacc acaaatgtcg gtgaataaat 3240721 catatcgaca ttattccgca catcagcaat taagtcttgc agcgccttga gggtattcat 3240781 cggcgttttt tcgaattctt tcatttcctc ttcaatttgc tccgggcttt tcccctcaaa 3240841 ctttttgtaa ttgcgagcgt atgaaagaac gccttgatac atgacctctt cactcttaat 3240901 atgcatcggt gcgcacattg ggacaattcc ctttatgggt acagtgtaac ccaatttcag 3240961 cgaaaaaacc ccgccaagcg acagtccgca ggcagcaatg ctctcataac cttcagattt 3241021 taaatattca tagccatcca ttacgttttt ccaccagtct tcgggccccg tatgtacaag 3241081 ttcttcaggc gggacgccat gtccttcata ttgaggcgcg tggcacgtat agccgcgttc 3241141 attcaaatat cgtcccagca tccttacatc cgctgtattt cctgtaaagc catgcagcaa 3241201 aagcaccgct ttgtctccgc ctttaaatgt aaatggtttt ggtgtcacaa ctttcatgct 3241261 catgtctccc tttctatctg cacgatcatt ttagttttcc acagtttaat cagaaaaaaa 3241321 cgttttgaat atcatccaga aacgtgaaaa aggcctgact tcacatcaga ccttatacaa 3241381 acattgccct ataggatata agcaagcgca atcgttaaca cgaaaaacaa gactgccagc 3241441 actaccgtaa tgcggtgcaa aattaaatca agacctcttg ctttttgttt cccgaagagc 3241501 tgctccgctc cgcctgaaat cgcaccagat aatccggcac ttttactgga ttgaagcaaa 3241561 acgacaataa taagtgcaat gctgacgata accaataagg taatcaaaac tgcgtgcatc 3241621 ccatacacct ccagactcac tggctacatt acttctattt tacatgaaaa gggttggcat 3241681 gtcacgctgt atcagacgcc aaaaggccgg ataagacgtt ttatcttggt taccctattc 3241741 atatgaaaag gtcaaaggag aaaagcgatg ccgcttatca gcatagacag caggaaacat 3241801 cttttttatg aagaatatgg acagggaatc cctatcattt ttatccaccc gccgggcatg 3241861 ggacgaaagg ttttttatta tcagcgcctt ctatccaagc atttcagggt gatttttccg 3241921 gatttaagtg gccacggtga tagtgatcac atcgatcagc cagcgtctat ttcctattac 3241981 gcaaacgaga tcgcgcaatt catggacgct ttgcacattg ataaagctgt gttattcggg 3242041 tattctgccg gaggcttaat cgcgcagcat atcggcttca cccgcccgga caaagtgtca 3242101 caccttattc tgtccggcgc ctaccccgct gttcataacg taatcggcca gaagctgcac 3242161 aaactgggaa tgtatctgct tgaaaaaaac cccggtttgc tcatgaaaat cctcgctggc 3242221 agccacacaa aagacagaca gcttcgcagc atattaacag accatatgaa aaaagcagac 3242281 caggcccatt ggcatcagta ttatctggat tcgcttggct acaactgcat tgaacagctg 3242341 ccccgcctag aaatgccaat gctgtttatg tatggcggcc tgcgggactg gacctttaca 3242401 aacgcaggct attaccgaag atcgtgcaga catgccgaat ttttcagatt ggaatatcag 3242461 ggacatcaat tgccgacaaa acaatggaaa acgtgcaatg agctggtgac agggtttgtg 3242521 ctgacacatc attcatagga atagaaaacg cttggcttcc ttgcgttttt tgttacttta 3242581 ttgacttttg tcaacgaaat catagtaaaa aagatcctca aatttcaaat taaaatagtg 3242641 aagcatttta ccaatcacaa gctgccccgg ccttctttct ccattcagca cgcggctcag 3242701 tgtggcgggt gagactccga tttccagcgc aagctgatta agggaataat cgttattaac 3242761 catatactgc aagacataat cacgtctaat ctgtatcttt tctactggca ctttcctcac 3242821 cttccattcc tgaaaaactt ttttctatac ttttacatta cggcttatgt taacttttgt 3242881 caatacattt ccagtctacc tattcccttt agtcaataaa catactaaaa tatgagtaac 3242941 agtgagggac ggggtgagat atatggaaag ctttggcgaa caattacggg cattgcgtga 3243001 agagagaaag ttaacagtca accagctggc gacttattca ggcgtaagcg cggccggcat 3243061 ctccagaatc gaaaacggaa aacggggcgt tcccaaacct gccaccatca aaaaactggc 3243121 agaggcctta aaaattcctt atgaggggct tatgtacaag gctggttaca tcgaagaagt 3243181 gcatgaagcc agggcccctt atgaaacgaa gtgcaagctg cttgaaaaag cggaggccta 3243241 tgacctgaaa aaccttgcgc ttcttgagaa cgaaaagtgg caatatctca ataaagaaga 3243301 tttgctcatg ctggatcatt atttttcgtt tatttcagat gaagcgaaaa aacggtctgc 3243361 tgatgactga ctcttgatag aaatgtgagg cgatagacca tgtcaccgtt cggacagcaa 3243421 ttacgggagc tgcgccgcgc ccgcaaactg acagtgaatc agcttgcggt gtactcaggc 3243481 atcagctcgg ccaccatttc aaaaattgaa aacggcaaac gcgggacgcc aaaacccgcc 3243541 acgattaaaa aactggcagc cgtcctgaaa gtgccgtacg aaaacctaat ggccgccgca 3243601 ggccatattc aggcctttcc tgaagaaatc cgcgaagcat ctgaaggcta tcaatccgtt 3243661 tatgaaattt accagacggc tgtcacacgc ggagcggagc acctcccgat tttcaatagt 3243721 caaaaatggg aacatctctc aaagcaggat attgaaaatc tcagcaaata cttcgatttt 3243781 ttgtcttcag aagcaaaaaa acgcgcctct tcctcataat cccctgtttc tctttctata 3243841 ttttatcaat cacgcttgca tgccctccct cgttatttgc gttataatag tgacagacga 3243901 ggtgaaaagt atgaaccaat cagaaatgtg tcctagattt gaaaaagcag tcgacatctt 3243961 aagtaaacgc tgggtcgctt taatcgtatt tcagctcttg aacgggtcgc agcgatttag 3244021 cgaaattgaa gcagcacttc caaatctaag cggcagagtt ctgtcagaac ggctgaaaga 3244081 acttgagctt gaaggagtag tgaagcggga tgtcatccct gaaactccgg ttcgcatcga 3244141 atattcattg actgataaag gaaaggcact agcacccata ttaggtgaga tttctaaatg 3244201 ggcgactgaa tggattgacc cttcctttct tgactaattg ctaaaatggt tctgatctca 3244261 aagacgagaa aagaaccgtt ttttattttc caggtgaaaa aaagatatct cagccgatat 3244321 atagtacatc cacacattac gtttttaaag gagaccacta tatgcgactg acgatttccc 3244381 gcaaattcag cctggtattt ttgacactga tcctgatcaa tttacttgta ggcggaatag 3244441 gcgttcttaa tatgcagcat atcattcaaa aaacagatga aatcaacaca aaatggattg 3244501 acggcatcaa aggaatcact tcaattaatt atgtaaccga gcacctgtct tctaaagaaa 3244561 aggactttct gatttataca gacaaaagta aaatggatac acttgatcaa gaaatgaatc 3244621 aaatcatgga agacattaac caaaagctcg ataactacga aaaaacgatc tccactgata 3244681 aagagcagaa actgttcgag cagcttcaaa ctaaagtgaa tacctatatg gatattcatg 3244741 cgcaaattat cgaaagcggc cgcacgaatg acatggacaa agcaagaggt ttattggttc 3244801 agactgaggc cagctttgag gatatgaaaa aaacaatcac tcagcttgtt gacttaaatc 3244861 aagaaggcag caacacagcg gtaaaagaaa cgaaggccgt ctatcataaa gggctcattt 3244921 acactgcttt gcttgtggca gcatcaatcc tcatcagcat tttcatctgg ctttatatca 3244981 cgcgaaacat tgtaaagcct atcattcgca tgaaggaatc tgccaatcat attgccgaag 3245041 gcgatttgtc gaacgatatg gaggccctca actcaaaaga cgagctgggt gatctgaatg 3245101 aagcgctgca aaaaatggta gggaatctga gagatattgt cggatattct aaagacatat 3245161 caagccgggt tctttcttct tcacaggtgc ttgcaaccgc aacgaatgaa acaagatccg 3245221 gcagcaaaca tattaccgag acgatgaacg aaatggctga gggctctgaa cagcaggccc 3245281 aagacgcggt gacgattgcc gaatcgatga atgagtttac cgaaagcatt gataaagcct 3245341 ataatcacgg catcacaatc agcgatacgt ctcaaaacgt tctcgaactc gcggtaagcg 3245401 ggaacgaaaa tatggctacg tcattacagc aaatgaaaac catccatcat attgttgaag 3245461 aagccgtgca taaagtgaga tcactggaac agcattctca ggatattaac aagctcgttc 3245521 aggtcatcaa cgggattgcc gagcagacga atttgctgtc ccttaacgcc gcgattgaag 3245581 ctgcccgcgc tggagaaagc ggcaaaggct tcgccgttgt ggcagaggag gtcagaaagc 3245641 tggctgacgg cgtttctgat tccgtgcagg acattacccg gattgtaaac gggacacagc 3245701 aggagatcca cactgtcatt acgtacttgg aaagcagctt tacagaagtc gaaaaaggaa 3245761 cggaaaacct gacagacacc ggacaggcta tgcagcatat caaacaatcc gtcacccatg 3245821 ttgcagacag cattaaggaa gtaacggatg gcttgaagca gttaacaaac caatcgatta 3245881 ccatcaatca atcgattgaa aatatcgctt ctgtatccga agagtctgcc gccggcattg 3245941 aagaaacatt ttcaattacc gagcaatccg cccattcgat ggatcaagtg cttctaaatg 3246001 ctgaagagct tgagcagctg gccaatgagc ttaatgagaa gatgggtcag tttacgattt 3246061 aaagagaaaa aagaggctgg actccagcct ctttttctat tctatgcagc tgattgaaca 3246121 tgtttcgccc cggttctttt tttcttcacc ggacttaatg cccgctccag ccaagccatg 3246181 agcaaatccg cccctaccgc catcaccgca gttggtatcg ctccggctag aataatcgca 3246241 gttccgtttg ttgcgtttga gccgcgtacg atcatgtccc caaggcctcc ggcaccgaca 3246301 aatgtgccga tcgctgtaat tccgatggca atgacgagag ccgtgcgaag gcccgccata 3246361 atgacagaaa gtgcgagcgg gagctcaacc attctgagca cttggaattt cgtcatgccc 3246421 attgcttttc cagattctaa gtaggcatgt tcaatactga taatgcctgt gtacgtgttt 3246481 cgaataatcg gcagcaggga atacagaaat aatgatagaa tcacggtatt tgcgccgagc 3246541 cccataacaa gcattaagac ggccagcata gcgagcgccg ggattgtttg aataacgttt 3246601 gttacggcaa acacccaggc tgacaaacgg cgaaaatgcg cgatgaggat tccggccgga 3246661 accccgacga cagcggcaaa taaaacgccg taagccgaca tgagaaagtg gcggccgaat 3246721 tcatccatga cgtaactgcc attctgcgcg taatacgtca ttaactgttc aagcacgttc 3246781 attgacctct tccccctttc acgattcgaa atagcgatgt ttttctaaat attccttggc 3246841 aacgacagac ggttctttga gattgccgtc gacttcatag ttaagctcct gcatcgtggc 3246901 tgtgtcgatt tttccgagca ttttcttgat gatgccttca agttcaggat gttctttgag 3246961 caccttttcc ggaacaaccg gagagcagtc gtacggcggg aaaaattgtt tatcatcctt 3247021 tagcattttg agaccatagg acttgattct tccatcggtt gaatacgcaa gcacaatgtc 3247081 catttttccg cttttcaccg cgtcgtacac aaggccgatc tgcatcggat acgtgccgcc 3247141 gaatgtcatg ccgtaggttt tcgtaaaatc ctgatagccg tttcctttga gcttcatcca 3247201 atagttatca acgcccagct ttaattgcgg cgcccatttt ttaacgtctg atacggtctc 3247261 taaatggtat tggtcggcca gctccttgct gactgtaaag gcatatgtat tatcaaaccc 3247321 gtaggagtca taccacttta aatcatatct ttttttaaac tcccgctgag taagcgccag 3247381 cgctttgtcc ggatcttttt caggttccat tctcaacgtg cctgtcagcg cgtctcccgt 3247441 atatcttgtg gccgcaatgt cgatttcccc gttcattaaa gcctgctgct gcaccgcgtt 3247501 ggagccaaga tttttaatcg ttgttgtttt gagatcagta tggtgttcga tcaactggcc 3247561 aagcatgctg gcgatgattt ctgattcgct catgctttgc gcgccgattt taatggtctg 3247621 gtctgcagca gcgctgagac caggaagcga acagccgctc agcgtcagcg ttgccgcaag 3247681 tgctaaacct atcattaatt tgagatattt tcttttcatg agccgcctcc ttatgacaat 3247741 tccttcaatc tctgcatgcc ggcaggtgtc agttttcgtt cagcaactgc cagcacataa 3247801 tcaatcacaa ttgccaatat cgtgacaggt accgcgcccc cgatgatata ttccggctga 3247861 tataaattca gtccgataaa aatgtaatca cccaatccgc cgcctccgat aaaggaagca 3247921 agcgtggccc agccgattaa gtaaatcgtc gatgttctga ttcccgccat gatcactggt 3247981 gcggcaagcg gcagctccac caagcggact tgttcagccg gcgtcattcc tattccttta 3248041 ccagactcga gcagattttt gttgacgccg cgaatgccgg tatacgtgtt gcgaagaatc 3248101 ggcaatacgg aatagaaaaa caaagccaca atggccggaa ccttccctac accaaggagc 3248161 gggataaaaa aagcgaggat ggccagactc ggcagcgtct gaatgatatt gacaatgccg 3248221 ataatggtgc cggctccttt tttcattctg gtaagcacaa ccccgagggg gacggcaacc 3248281 agcacaccta agatcacagc aatgagcgat atcgtaatat gctcgtatgt tttataaaga 3248341 agctctcccc cattggtttg caaaaattga acaatatgat gcatgactta tcgcccctcc 3248401 ctatgacaat gctgcgagct gcttttcttc tccccagagg gagtcataca cgatgtcgac 3248461 cagacttgcc ctcgtcacaa ttccgatcag gcgtcggtct tcatccacaa cgggaacata 3248521 tttgacaccc cgttttaaaa ttttgcggac cgtgtcgcgc agcagtgtgc cgcccagtac 3248581 tgtgtatata tcttcatgta aaacttcact gacgagattg gcctttttcc ggcattgatc 3248641 aatgatttca acatcgacat agccttgcag aacgcgctcg tcattgacga ccagcaatga 3248701 atcgacccgt tcctgcctca tcagctgaat ggcctcagaa agcgttttat ccgcggtgat 3248761 cgttacaggc tgtgtgttca taatctggtc aacccgttca acatccgggc tggatgactg 3248821 aatcagccgc tccttgccga taaattcctc aacaaattcg tctgccggat ttcttaaaat 3248881 gtcatcgggc gttccaactt gaacgatttc tcccgctttt aaaatcacaa tccggtctgc 3248941 cagcttaatc gcttcatcca tatcgtgggt aacaaatacg atggttttat gtaaggtttt 3249001 ttgcagtttt ttaaattctt cctggaggga atccctcgta atcgggtcga gtgccccaaa 3249061 cggttcatcc attaagataa gcggcggctc cgcggcaagt gcccgtaata caccaattcg 3249121 ctgctgctgc cccccgctta attcatgagg gtaacggtct acatattctg gccccatatc 3249181 gaccaatttt aaaagctcac gcgcccgctc tttccgctgc tgctccggcc atttcagcag 3249241 ttttgggacg agtgagatat tctgctgaat ggtcatatgg ggaaacaggc cgatctgctg 3249301 aatcacatag ccaattttgc gcctgagctc tacaggatcc tggtccatga tgttttcgcc 3249361 gtcaatgaaa atcttcccgg cggaaggctc aattaatcgg ttaatcattt tcattgttgt 3249421 cgtttttccg cagccgctcg gcccgataaa gcagataaat tcgccttttg caatcttaag 3249481 atttacgttg ttcacggctt ttttgccgcc cttgtatgtt ttcgagacat tttctaatgt 3249541 cagcaaacat cgcacctcca aaattaagtt tattcaattt gttcagttta aatttaattt 3249601 ttcagacaat tgaatgcttc ccattataga ataaagttta taaaataaaa agtttacaat 3249661 ttgttcatat tatttataaa gtatgtgtaa acgctgattt acccgcattg acgtgtgttg 3249721 atctccttat tgctccaatt tcctgccaaa ttctcttttg acagcatttt cgccgtatca 3249781 aaaatgtggt atattgacat cggaattgtt agctgaaagg atgaaaccgt tggagaaaga 3249841 tccgttaacg atcattgaac aagccgagga ccattttata gaaagaatcg cggaaaacat 3249901 gcatgcattt ggaatgccct ctaccgtcgg acgagtgctg ggcattattt atatgaatcg 3249961 aaaaccgatg acgcttacgg aattatctga ggccaccggc atgagtaaaa cacgtatgag 3250021 ccaggtagtg cgggaaatgc ttgatgccaa cattgccgag aaggtattcg aaaaaggcgt 3250081 gcgaaaagat ttatatgagg ttgagcagga ctactatcaa acatttatca cgctgttttc 3250141 agccacctgg agcaaagtcg tcagcaaaaa caaaatgatg cataaaaaac tcaatcggga 3250201 gctgcttagc gtgttggatg aagagcttac tcctgaagcg gaagaaaaag tgaatgagct 3250261 gctgaaggaa ttaaaggaat ggctcgatta ttataattgg ctcagccgtt tgattgagtt 3250321 ttttgagagc gaagacattt ttaaatatgt gccgaagccg taaaaagttc ccaaattcaa 3250381 ttctgggaac ttttttaagt ccaatccaaa tggttgaata tcaaacttca agaaaacaaa 3250441 caaaataatg cataatttac attaatttat taattatcca ttttttgttg attattctga 3250501 ctagctatta tataatcttt ttgaaatgat tatattagct tagaggaggt aatctacatc 3250561 aaaaaaaagg gaattattac tgtaatgact atatgtttcc tattattttc ttcttattac 3250621 tttagcaata tttcacctca gaatccactg ttcaaaaaaa attttttgca acaattgtct 3250681 ccccaaggct ttggctttta tagtaaaagc cctacagaag aaaacatttc atttcacaca 3250741 aaagaaaatt taaagttacc taatgcactt cccaataatt tttttgggat aaaaagagaa 3250801 ggaagagttc aggcaataga attaggcaaa attgtagaga atatcgatcc aaagaattgg 3250861 aaaacttgtg aaaacaacaa ctcctgcaca aatttagaga aacaaataaa gcctattaag 3250921 gttataaaaa atgaagatta tatacatctt agcaaaggag aatacctaat atatcgccaa 3250981 aaaccactct catggtattg gatagacttt aagcaaacta cctcttttga aagaaaggtg 3251041 ctaaaaataa aaatagtatg aagatattaa atagtttaga aggttatatt gacacctata 3251101 atccatggaa aaatacatat gcacttttta gaagtttact tggtttctca acattactag 3251161 tactattatt caatagtact gatattttat ttagttatag tgcaaataat gtcacatgtg 3251221 aaaatgtcta tatccctacc gctttttgtt ttgctaaaga atatagtatc aattttgaga 3251281 ttataagata cttaatgatt tttatattaa ccttagtggt tatagggtgg agacctagat 3251341 ttaccggttt atttcactgg tatatttgct atagtattca aacttcagct ttaactatcg 3251401 atggtggaga gcaaattgca actgttcttt cttttcttat attacctgtt acattattag 3251461 attcaaggcg aaatcattgg aatataaaga aaaacaataa tgaatctttc acaaagaaga 3251521 cagtattgtt ttatataatg acaataatta aaattcaagt ttttatcatt tatttaaacg 3251581 cagctttaga gcgattgaaa aataaagagt gggcagaagg aacagcaatt tactatttct 3251641 tttctgatcc ggtgtttgga ttacctgaat atcaacttaa cttaatgaat ccactacttg 3251701 aaagcaattt tattgttgtc atcacttggt tagtaactat ttttgagttg ttcttagcag 3251761 caagcataat ttcaaatatc agaataaaga gaattgccct tgttttggga atattatttc 3251821 atattgggat aatattcagc attggtattg taagttttgg cttgatcatg atatcagcat 3251881 taattatata tctgcatcct gtacaacaaa atatcactat gaattggtgt tctcctttat 3251941 ttaaatatat atatgtaaaa ggaaagagaa atttcaaaag aataggaggt gaatcagtca 3252001 agtttcttac aaaattgttt catagctaac atttagataa tggagaaata acttaatgga 3252061 ggtataataa tttgaaaagt aaattactta ggctattgat tgtttccatg gtaacgatat 3252121 tggttttttc attagtagga ctctctaagg agtcaagtac atctgctaaa gaaaaccata 3252181 cattttctgg agaagattac tttagaggac ttttatttgg acaaggggaa gttggtaaat 3252241 taatttcaaa cgatttggac cctaaactcg taaaagaggc aaatagtaca gaaggtaaaa 3252301 agttagtaaa tgatgtagtc aaatttataa aaaaagatca accacaatat atggatgaat 3252361 tgaaacaatc gattgacagc aaagacccta aaaaactcat tgaaaatatg accaaagcag 3252421 accaacttat ccaaaaatat gctaagaaaa atgaaaacgt aaaatactct tctaataaag 3252481 ttactccatc ttgtgggctt tatgccgtct gtgtagcagc tggatattta tatgttgtgg 3252541 gcgttaacgc agttgcatta caaacggctg ccgcagtaac aactgcagtg tggaaatacg 3252601 ttgccaaata ttcctcttca gcttctaata attctgattt agaagcggct gctgcaaaaa 3252661 ccctaaaatt gattcatcaa taatccatta taattgagtg tcttgcggat tgctccgcaa 3252721 gacacttttt caacgtgaac cgtttaattt tttgtaataa tgatatgaag ctagtgttga 3252781 aataactaat gctagaagaa ctagcacaat cataataaga attatatatt ctcctgtaaa 3252841 aaatgaaaga acagctatta taaaaccaca cactacaagt actttagagg caaagcgatt 3252901 tcccagtttc caaacagtct catcttttaa tgtccaaggt gtcctcaatc caataagatg 3252961 gttttgttct gctagctgca tagaatttcc accaataatt aaaaagatac caacaccaag 3253021 ccctattatt aaatcaatat tcacttcgta tcctaaactt atcaatagag ttgagagttg 3253081 taaaatatat aaaaggatta acatattatt agaagctagg aaaagcaatg ctttattttt 3253141 ttgtgtagac ttaatagtta acatataaaa agtaagataa taaataagca taacaacagg 3253201 tataataaat attgttaaag gtttagatac aattgcagcc ggtttatttc ctgaccattg 3253261 tatcggtatt tcttctggaa ggtattgata taatataatt gaagtcaaga aactcaaaca 3253321 tacaataatt atggaaatta tatttttctt cataaatcgt tatccccttt atttataaag 3253381 ttaagcatcc aatttattga gtcttgaagt actgttgtat ttagagagta ataaataaat 3253441 tgtcctttgc gatggtcact tatgacttcc gcttgcttta aaatattcaa gtggtgcgaa 3253501 atactcggtt tgctgatatt aaaatgctca gcaatatctc ccgcagtcat atcccctcct 3253561 tttaacaaat ccaaaatttt tctccttgtt ggatctgata tagctttgaa aacattattc 3253621 atagcgtttt ctcctttaca aaaaaacatt tagacattta gatatttgta taaatgtatt 3253681 attttcatta taacttgaat ttttttaaaa acaaccctca aattggttat aatatctgat 3253741 ttttgtattt tttcaaatac tcggataatc ccaacgctgg aaaatatgtt taacagatac 3253801 taacacatgt tgtttattta aaaaaaccac ctctgttgta tttaaataga ggtggttttt 3253861 ctatcagcta taataaaatt tccttttttc tttttaatcg ggcttaatgc tcgttcaagc 3253921 cagcccatga ccaaatcggc aatcaccgcc atcagagctg tggggatcgc tcccgctaat 3253981 ataatcgcgg ttccgtttgt ggcgtttgat cctctgacga tgatgtcccc gagaccgcca 3254041 gcaccgacaa atgtcccgat ggccgtaatg ccgatcgcaa tgacaagcgc ggtgcgcagg 3254101 ccggccatta tgacagaaag cgcaagcgga agctcgacca tccgcagcac ttgaaatttt 3254161 gtcatcccca ttgcttttcc cgattcaaga taggcgtgct caatactgat aatccctgta 3254221 tacgtatttc tgataatcgg cagaagagaa tacagaaata atgacaatat caccgtatta 3254281 gcgcccagcc ccatgacaag catcagcacg gcgagcatgg cgagagccgg gatggtctga 3254341 atgacattcg tgaccgcaaa aacccatccg cttaatcttc tgtatctggc tatcaggatg 3254401 ccgagcggaa ttccaacaat ggcggcaaat aaaacgccat acaccgacat cagaaaatgg 3254461 cggtaaaatt cctgcagcac gtaaccgccg ttttgcgaat agtatgtgcc aagctgctgt 3254521 agtacttcca tatgatccac ctcttttctt agtcaaaata atgatgtttc tctaaaaatt 3254581 cctttgctac gacagacggc tccttcagct tgccatccac ctcataatta agttcctgca 3254641 tcgtttccgt gtcgatttgc ccaatcagct tattgatcac accttcaagt tccggatgct 3254701 ccttaagcac cttttccgga atcaccggtg aacagtcata cggcggaaag aaacgcttat 3254761 cgtcttttaa gattttcaga tcatatgctt taatccgtcc atccgttgaa taagccaaaa 3254821 ccgcatccat tttcccgttt ttgactgcgt catagactag cccgatctgc attggataag 3254881 ttgtgccgaa ctcaaagcca tatgtgctga caaagccttt atacccgtcg ccttttcgtt 3254941 tcagccaagc attgtcgacg cctaatttat attgggaagc atttttcttc aggtcagaca 3255001 cggtgttaat atgctccttt tccgcaaact tttttgttac ggtgaaggca tatgtgttat 3255061 caaagccgta ggaatcaaac catttataag aaaagcgctt ttgaaactcg ttctgcacaa 3255121 tgttcagcgc ttttttcgga tctttctccg cttccttgcc gagggtgctt gttaaatctg 3255181 ttccggaata gcgcgtggct gaaatatcaa tgtcaccgcc cagcatcgct tggtgctgaa 3255241 catagtttga gccgaggttt ttcactaaag cagtattcaa atctgtatca tgttcaataa 3255301 gctgcgcgat catattcgct acaatttctg attctgtcat gctctgcgcc ccgattttga 3255361 tcgtatcgtc agaagcgccg cctagacccg gcagagagca gccgcctagc agcatgacaa 3255421 agacgagagc aaacgcgcca agccatttga tttttgtcat tttcaacagt gccaactcct 3255481 tacgatactt ccttcatccc ttgcaagcct ttcggcgtca cctttcgttc tgtcacagcc 3255541 agaacataat caataataat tgccagaatt gtgacaggca cggcaccgcc aatgatatat 3255601 tcaggctggt ataggttcag tccgataaaa atatagtccc cgaggccgcc tcccccgata 3255661 aacgacgcaa gtgtcgccca gccaattagg tagatcgttg atgtgcggat ccccgccatg 3255721 atgatgggaa tcgccagcgg gatttcaacg agccgaatct gctcccagcc ggtcatgcca 3255781 attcctttcc ccgattccag gaggttttta tttacacctt taatgccggt atacgtattg 3255841 cgcaggatcg gcagtaccga atagaaaaat aaagcgacaa tcgcaggcac ttttcctacg 3255901 ccgagaagcg gaataaaaaa ggctaaaatc gccagactcg gcagggtttg cacaatgttt 3255961 acgaaaccga taaccgcacc tgcgcctttt ttcattctgg taagagcaac gccgagcggc 3256021 actgcaacga taatgcccaa tacaacggct atgagtgaaa tatataaatg ctctcctgtt 3256081 ttatacagca gctctccgcc gttcgtttgc aaaaaagtca tcatttgatt catcttaaaa 3256141 gagctcctcc cctggtcaga tcgtcatgag ctggttttcc tcgtcgcccc aaatggaatc 3256201 gtatacgata tcaacgaggc tcgctcttgt cacaatccct gctaaatggt tctgttcatc 3256261 gaccaccgga acatacttga tcccctgctt caaaattttt cggactgtat cgcgaagaag 3256321 cgcccctttt tgaacggtat atatatctga acggtataca tcgccaacga tgctcgcttt 3256381 tttgcggttt tgatcaatca tttccacatc aacatagccc ttcagcacgt tttgccggtc 3256441 cacaacgagc agcgagtcaa cacgtttttc tctcatcagc tgaatcgcct gagaaagcgt 3256501 tttgtccgca gataccgtca ccggcgttct gttcatcatt tgctctaccc gctcgatatc 3256561 cggtcttgac tgaatcaggc gctctttccc gataaattct tcaacaaact catttgccgg 3256621 gtttcgaaga atctcatcag gtgtgccgac ttgaacgatt tctcccgctt ttaatatcac 3256681 aatcctgtca gcaagcttaa tcgcttcatc catatcgtgg gttacaaaca caatcgtttt 3256741 gtttaaggtt ctctgcagtt ttttgaattc ttcctgaagg gaatcacgcg taatcggatc 3256801 aagcgctccg aacggttcat ccattaaaat gagagggggt tccgctgcca gggcgcgcag 3256861 cacgccgatt ctctgctgct gtccgccgct gagctcatgc ggataacggt ctaaatactc 3256921 tgggcccata tccacaagct ttaacagctc gcgcgcccgt tctttccgtt tttcctcagg 3256981 ccatttcagc agctttggta cgagtgagat gttctgctgg atggtcatat gggggaacaa 3257041 accaatctgc tgtatcacat agccgatttt tctcctcagc tcaaccgggt cctgttccat 3257101 aatattttct ccgtcgataa agatccttcc agacgatggt tctatcagtc tgttgatcat 3257161 cttcatcgtc gtcgtttttc cgcagccgct cgggccgata aaacagataa attcaccttt 3257221 tgcaatatct aaatcaatgc tgttcacagc ttttttgccg cctttatata cttttgacac 3257281 ttgttccaat ttcagcaatc cgtgcacctc cgcaggtttc ctttaaattt tctgaaaagt 3257341 ataatcctta ttatagtttg aactttgtaa aataaaaagt ttacaatgtg ttgaaattat 3257401 atgttattta tagattattt attgttatga ccgagacgga aagggtgttc ttacaattac 3257461 tccggatacc tcccacttcc tctgcattca gctattttca acaccaggaa gaaatatgat 3257521 atattgacac catcaattgc catttgaagg gatgatcagc tgtgaaaaaa accgctctcg 3257581 acatcattga acatgctgaa gagcatctca ttgagaagat tgccgaaaat atgcatacgt 3257641 ttggaatgcc ttcaactgtc ggacgtgtgc tcggaattat ttatatgaat cgaaaaccaa 3257701 tgaccttaag cgagctctct gaggcaacgg gcatgagcaa aacacggatg agccaggttg 3257761 tccgggaaat gatcgatgcc aatatcgccg aaaaggtgtt tgaaaaaggc gtacgaaaag 3257821 acctttatga cgtcgagcag gattattatc aaaccttcat ttctttattt gcggcgaatt 3257881 ggacaaaggt cgtgagcaaa aacaaagtgc tgtataaaaa attaaaccgg gagctgagtg 3257941 atcttttaca aagggacggg cttaccccgg aagcggaaga gaaagtcaat cagctgctga 3258001 atgaattaaa agaatggctt cattactatg attggctgag caggttgatt gaattttttg 3258061 agagtgagga agtctttcgg tatgtgccga aaacaaaaga atgcagctct ctaaaataag 3258121 agagctgctt tttgcatcat gaagttaaga ccggaaacat gcctttcagc ccggcaccaa 3258181 tcatcccgac cgcaaccacg gctaagatta atcccatcag tctggtaatc acattcatct 3258241 cggtttttcc gagtttgctg ctgataaaag cagaatagtg gaaaaagaga aaggtcaggg 3258301 caataacggc ggctatgccg atcatgacag ccgcataatg accaatgccg ctatgtccgg 3258361 cggaaaggct catcactgtt gcaatcgttc cgggcccagc aatgatcgga atggataaag 3258421 gtgtgactga tatatccgct ttttccttgc tttccttatg ttcatcatgg tgaagagatt 3258481 gcacgtgcga ttctttcgca ttcaatagat tataggcaat gccgaaaatg aatatgccgc 3258541 ccgccactcg gagcgcgtga atgttgatat caaacagttt aaagataaga tgaccgaaaa 3258601 ccaaaaaagc tgcgagaata aaaaaggata aaatagctgc cttccgggca atcgcttttc 3258661 tttccgctgc agtatagcct tctgtcagcg tcagaaatat cggtacgttt ccgatcggat 3258721 tcgatactgc gaataaagaa atgaagacgt gaacgataaa tgagaacatc atatacctcc 3258781 ttgttgatag tctctgcaca ggaaatagaa tgattctcca cccttttacc cggaggcgat 3258841 ttcccggtaa acctttatag cctgtcagaa acgcgccatg ctacaatgaa gtgacaaatt 3258901 gaataggaag gacgtataca gatgttcaaa aaaattgcgg cagatgcctt gggcttatct 3258961 gatatcggaa aaattatcga acctcaggac tatgacaaaa cagacgcaga tgactatgtc 3259021 atgcatgaag ataatgagaa aatttatttc ttgattaaaa caaaagcaga cgagtattgc 3259081 tttacgaacc tggccctgat ccatgtggac ggcgaacgcg ccacttcctc aaaacgaacg 3259141 ttgaaacgct atccttattc gcaatataaa atctctgacg tttttcttga aactgccgga 3259201 aaagtggatt tggatgttga aattaagttc aagctgggcg gtgaacaatt cgacattgat 3259261 gtccacaaag accagattga aaagttaaaa gacctttata aagcactgct tcgcatcgct 3259321 gaaacaacct atgaaaatga cattttaatc aatcaagcgg agcaaagctt agataaagca 3259381 gtgacgattc ttcaccatac ccgccctgag cacgtcaata ttgaaacgca atacaaagag 3259441 ctgaccgaat tcggattcac ttggctgaca tccgttcgct cgcagtatca tattaaggat 3259501 tttggggatg tatttgagaa atatattaat aactagataa aaaaagacac agctgctatc 3259561 gtgctcgtgt ctttttttgt atgaatattg attactttac aacttttttc ttttataata 3259621 aaactattag tctattttcc ctatattaca gataaaggag ttattttatg tattgtcctc 3259681 aatgcggcca tcaaacagat ggcggaaatt tttgtgagaa atgcggatca ccgctccccg 3259741 gtcaatcagg ccaccagcat gcagctcaaa ctggagccgc tgcaaagcaa gcagcaaaac 3259801 agttcggttc atttgtctta tccgtcctga aacgccctta tcaggaatgt aaagcaacag 3259861 gcggagaaca gctgatcagc gcaatcatta cgatggttct tttcagtttg ctgacccctt 3259921 tgatgtttta tattcttttt tcagacggtc ccggaagcgt aagctttaca gcaatcttct 3259981 tagagccaac catttatttt attttatttc tatttggcct gcatgcatgc atctttttcg 3260041 ccctgaaaat cgcgggaaac caagtgtctt tcaaggattc attctcaaga ttcggagcat 3260101 ttcttattcc ttttacggct attttgattc ttgccctttt cttcttttta ttacatacag 3260161 acatttgctt taccatatta gccgttggtt taatcggtgc attcttcgcc attcctcctg 3260221 cgatgctgag cagttaccag cattcatata aagggaaggt tgatttcatt tactcaacga 3260281 ttgtgattta tctgatcatc tgcgttacat ttcagcttat tatcgaacac tatgtcaaag 3260341 aaattttccg ttatatgctc ttttaaaaac aaccccatca cctgctggtg atggggttgt 3260401 tttattgaat agacgttaag taaattcttc cgttcttcac tacgccggtg taggtccagt 3260461 tatatgttct gagctttgga ctgccgcctg attttgtgat atagaattct tcatacgtct 3260521 taatcgtgat agccgaccca ttttggctcc agcttttcac ttcatagtta ttaaagtctt 3260581 ctgttgtccc ctctttattt aatttcgaca cgagatgctg ctggtcggaa taaagggaac 3260641 tgcctttttc aaggctgtct tccatcagtg agaaattatt ttgattcacg gcatctgcct 3260701 gactttgcag ataactgccc ataaataatg tcacttgttc atctgtaaca tcgccgcttg 3260761 cagagctttc actgcctttg tttttcgagc cagcccaggc ggaagtgtat gtctctggtt 3260821 tatcattttt gattttcttt atatttgtgc ctgcagattc gaatgttgat tctgcatctt 3260881 cgaaaatcca ctttttctgt tttttatcat atgaaagaag atattcataa ctcggactgt 3260941 cgtcagtcat ttcagacttt gtatagtcgt tatacgaaga agactggtga agttcttttc 3261001 ctgttaccga tacctgccac gttccgtcgt ttttctgaga gagggcaaat gtgtccaggt 3261061 caaaatcagt ttccaagtat ctatctttta agtatgaatc cgcgcttttc atagaatcga 3261121 cggtgtcctt cgtctccgcc ttccaattgg cacttgcctc tgtcatctgg gctgtattcc 3261181 catcagatag agctttggag tattgttttg ttgttttgac aattgtgttc ataatctgtt 3261241 cctgtgtatc ttgatcagga attaacgtta actccatttc tttatcatcg atcggaacgc 3261301 cggcagtttt tgtttttccc cacggaaatt ctgcctcgac tgaagctgtc attgatccat 3261361 ctgtcagcag cggaccatat gttacggatt tgaacggatc tttatgaatt gatttaccgt 3261421 taatcagcaa atctcccttc ccgctcttga tgtcattcgc taagctgaat gtcacatcgt 3261481 ctgcttccaa tgagagatca acacgaaagc tgctatcgcc aatcgcctga atgtcttcct 3261541 ttttcacaag gtcaacgaca tcgtttttca gtttggctga gactgtatat tcgccgggaa 3261601 tgtacggacc aagggtttgt gcttgatctg ctttctttac agatccggct tcctctttat 3261661 tgacatatag atcggtattt ttataattgc tgctcacttc aaaataaaca ggtgctacct 3261721 ttaagtcata atggtcaaat accagcaggc ttttcccgtc tttttccgca tatacgatat 3261781 ccttctgggc tgtttcatca cgcagcgatg caaaaagttc atcttttttg tctggatgat 3261841 ccttcaaata tgtaagaaac ggttttacat tatttttagt gagtttaaga ttgtcattta 3261901 ccggtgtaag cagagtcgcg atttggtcct gatccccatc atttacggcc tgttcaaact 3261961 tgtctactaa cctatccttt gaagtaaaat acgctccggt tttatatgcg gcgaataata 3262021 taacgcacgc cgcggcaatg ctgctccata aaatgatggt tttcttaggg atcggttttc 3262081 gcggagcctg cctcgtttct gcagtgctag ctgtttcttg atttgcctgt ttgctgcccc 3262141 ctccgatcgg ggtgccgcat tgtttacaaa acttggctcc ttcattattc tgggagccgc 3262201 aattcttaca aaataacatg actttcctcc tattctacta atttgataac atttactgct 3262261 tttcatattt tataataaaa cagaatgaaa ttgggaacga atgaaaaaat taaatgtcta 3262321 tcagactaaa aaggtggaat gaatatgcaa aagctcagga ttgaattagg agaagaaaca 3262381 aatgacgaat tatatgatct attgctgctc gccgatccat cgaaagacat tgtagatgaa 3262441 tatcttgaga ggggagaatg ttacacagct tgggccggtg atgagcttgc aggggtttat 3262501 gtattgctaa aaacaaggcc gcaaacagtt gaaattgtaa atattgcggt aaaagaatct 3262561 cttcagaaga aaggctttgg caaacagctt gtacttgacg ccatcgaaaa agcgaagaag 3262621 ctgggggcgg acacgattga aatcggaacg gggaattcga gcattcatca gctttccctc 3262681 tatcaaaaat gcggattccg cattcaggcg atcgaccacg atttctttct cagacattat 3262741 gatgaggaca tttttgaaaa cgggattcaa tgccgcgata tggtaaggct ttatttggat 3262801 ctctgaaagc ataaaaaagc cgccgagaga aaatcccggc ggtcttttta ttacttgttt 3262861 aagttgtaga aagagttgat accgtggtat tgagcagttt cagccaactg atcttcgatg 3262921 cgaagaagct ggttgtattt cgcaacacgg tccgtacgag acggagcacc tgttttgatt 3262981 tgtcctgcgt ttgttgccac agcgatgtca gcgattgtgc tgtcttcagt ttcaccagaa 3263041 cggtgagaga taacagctgt gtagcctgcg cgtttcgcca tttcgatcgc atcgaatgtt 3263101 tcagtcaatg taccgatttg gtttactttg atcaggatag agttgcctac gccgttttta 3263161 ataccttcag aaagtttttt cgtgtttgta acgaagaggt cgtcaccaac aagctgaact 3263221 tttttgccaa gacgctcagt aagaagcttg tggccttccc agtcgttttc gtcaagtccg 3263281 tcttcgatcg agatgattgg gtatttagaa acaagctctt cataccagtc aaccatttca 3263341 gcagatgttt tcacaacgcc ttcgccagac agatggtatt tgccgtcttc tttgttgtag 3263401 aactcagaag atgcagcatc catagcaagt ttaacttctt cgccaggttt gaagccggct 3263461 ttttcgattg cttcaacgat tgtttgaagc gcttcttcgt tagaaccaag gtttggagcg 3263521 aatccgcctt cgtcacctac agcagtgttt aagccttttg cgcttaatac tgatttcagg 3263581 ctgtggaaga tttgagcgcc catgcgaagt gcttcacgga agttaggagc acctacaggc 3263641 atgatcatga attcttgaat atccacgttg ttatcagcat gctctccgcc gtttacgatg 3263701 ttcatcatcg gtacaggaag cgtttttgag ttgaatcctc caaggtattg gtaaagagga 3263761 atctgtaaga aatcagcagc agcacgcgca caagccatag atacgccaag gattgcgttc 3263821 gcaccaagtt tgcctttgtt ttcagtaccg tcaagctcga ttaaaagctg atcgattgcg 3263881 ttttgttcag ttacatcaaa gccaagaagc tctggagcaa tgatttcgtt tacgttgtta 3263941 acagctgtta acacgccttt tccaaggtaa cggtctttgt cgccgtcacg aagctcaacc 3264001 gcttcgtatt cacctgtaga agctccgctt ggcactaatg cgcggccgaa agctcctgtt 3264061 tctgtatata cttcaacttc aactgttggg ttgccgcggg agtctaatac ttcgcgtgca 3264121 taaacatcaa caatgtatgg catgagtttt gtctctcctt ttgattttca aattattttt 3264181 gaattaaaga tgttcctgtc atttctttcg gtttttcaac accaagaagg tctaataacg 3264241 ttggtgcaag gtcgcctagg attccgcctt cacgcagcgt aatgccttct ttcgttacaa 3264301 tcacagggac tgggtttgtt gtatgcgcag tgtgcggttc gcctgattct gtaatcagaa 3264361 tgtcagcatt accgtgatca gcggtaatga tagcgtgtcc gcctttagca aggatcgcgt 3264421 caacgacttc gcccaagcat tcgtccactg cttcaattgc tttaattgtt ggttcaacca 3264481 ttccggagtg gccgaccata tcagggtttg cgaagttaag aatgatcgcg tcatgcttgt 3264541 cagcttcaat ttctttgaca agcgcgtctt tcacttcata cgcactcatc tcaggcttca 3264601 agtcatacgt tgcaacttta ggcgagttga tgagaatacg ctcttcaccc gggaattcag 3264661 cttcacggcc gccgctcata aagaacgtga cgtgcggata cttttcagtt tctgcaattc 3264721 gaagctgttt taacccgtgc tgagataata cttctccgac tgtgttatca agatttatcg 3264781 gtttaaacgc tacatagccg tcaactgttt cactgaagtg agtcaggcag acgaaataca 3264841 ggttctttgg ataattctcg ccgcggtcga agtcacggaa gtctttgttt gtgaacgtgt 3264901 tggaaatctg gatggcgcgg tccggtctga aattatagaa aatcacagaa tcgccgtctt 3264961 ggattttcgc aacaggctca ccgttttctt ttgtgatgac agatggaatc acgaattcat 3265021 cgtagatacc atttgcatat gaatcatcaa caacatccag ggcgctgcgg taagatgggc 3265081 cttcgccgta cgccattgcg cggtacgctt tttctacacg gtcccagcgt ttgtcgcggt 3265141 ccatagagta gtaacgtccg gaaatgctgg cgatttcacc tacaccgatt tccttgattt 3265201 gatcgttcaa ctggttgatg tacgttttcg ctgtctgcgg acctacatca cggccgtcaa 3265261 ggaagccatg gatataaacc tttgtcagcc cttctttttt cgcaagcttt aacagtgcga 3265321 ataaatgatt gatatggctg tgcacgcctc cgtcagataa aagaccgaac aggtgcaagg 3265381 ctttgttgtt ttctttcgcg ttgctgatcg cgtcaaggaa tgtttgattg cgttcgaact 3265441 ctccttcacg aatggcaaca tttacgcgtg ttaagctttg gtacacaata cgtcccgcac 3265501 cgatatttaa gtgacctact tcggagttcc ccatttgccc ttcaggaaga cctacagcct 3265561 cgcctgaagc agtcaaagtt tgatgaggat actggttcca atagcggtca aaattcggtt 3265621 ttttcgctaa agcgactgcg ttccctactg tttcgttacg taatccgaac ccatcaagaa 3265681 tgatgagtgc agctggtttt ttactcatat tgaccttcct ccaataattg aacgaatgac 3265741 tgtggctcaa ggctcgcgcc gccgaccaaa gcaccgtcaa tatcggactc tgccatatat 3265801 tctttaatgt ttgcaggctt tacgcttccg ccatattgga tgcgaagctt gtctgcagct 3265861 tcttggctga agctttcagc gacggtttta cggatatgcg cacacacgtc attcgcatct 3265921 ttcgctgtag aagatttgcc tgttccgatt gcccagattg gctcatacgc aataacagaa 3265981 gcagcaactt gttcttcaga aagaccagca aggccttttt tcacttggtc agcaacaaga 3266041 tcatttgttt tgccggcttc acgctcttca agcgtttcac ctacacagat gatcggcaca 3266101 atgccgtgtt tgaaagctgc gtgtgctttt ttgttaactg tttcatcagt ttcagcgaac 3266161 atttcacggc gctcagagtg gccgatgacg cagtagtcaa cgccaaggtc tttcagagca 3266221 accgggctga tttcgcctgt gaacgcgccg ctttcttcga agtgcatgtt ttgagcgccg 3266281 acttttaggt cagtgccttt cacagcagaa gcaagctttt ctaagaaaag cgctggcgcg 3266341 caaacaacag cttcagcttt gtctgctgct ggaatggaag atttcacttc ttcaacgaag 3266401 ctgacagctt cgccgagtgt tttgttcatt ttccagttac cggcgataat tggttttctc 3266461 atctgttcca cttccttata gcagttttga gattatttat cgttcagtgc agctacccct 3266521 ggaagctctt tgccttccat aaactcaagg gatgcgccgc cgcctgttga gatgtggctc 3266581 attttgtcag caaggccgaa tttttcaacc gctgccgcag agtctcctcc gccgatgaca 3266641 gagtatgtat ctttcgcctc tgccaatgct tccgcaaccg cttttgttcc ttgagcgaac 3266701 aagtcgattt cgaatacgcc cattggtccg ttccacacga caagtttgct gtttttgatg 3266761 acgtcagcat acgtttcgcg tgttttcgta ccaatgtcga ttgcttctaa atcactaggg 3266821 atttcagaga tcggcacaat tttcacgttt gcatcgttag agaaatcatc tgcaacgagt 3266881 acatcttcag gcatgtagaa gttaacgcct ttttctttag cgcggtccat aaatgatttc 3266941 gcaagctcga ttttatcctc ttcaagaaga gatttcccga cttcatagcc aagcgctttt 3267001 acgaaagtat aagcaagacc tccgccgatg atcaggttgt ctactttatc aagaagactt 3267061 tcgattacac cgattttgtc ttttactttc gctccgccga tgatcgctgt gaacgggcgg 3267121 tcaggattgg aaaccgcttt tccaagtaca tcaagctctt tttccattaa gaaacctgca 3267181 actgctggca gatgctcggc aattccagct gtagatgcgt gagcacggtg ggcagcaccg 3267241 aatgcgtcat ttacatatac atctgcaagc tcagcaaatg cttttgcaag ctcaggatca 3267301 tttttctctt caccaggata gaaacgtacg ttttccaata caagaacgtc tccgtccttc 3267361 atctcagaaa tttgtgcttt tacagcatcg ccgtatgctt catccgcttt tttcacttct 3267421 ttgccaagca gttcgccgag acgtgcagcg acaggagtta aacgaagctc ctcaaccact 3267481 tcgcctttcg ggcggcctaa gtggctcgca agaaggactt ttgcgccttg gtctgcaagg 3267541 tgtttgattg ttggaagcgc agcacggata cgtgtatcgt ctgttacttc cccgtctttc 3267601 attggaacgt taaagtcaac gcggcagaat acaactttgc cttttacgtc gatgtctttg 3267661 agagtttttt tattcatgcc taggagatcc tccttcaaaa tggtttgcat acagcacgaa 3267721 aaacgtgaaa ccgtctgttc aagcgataac tccgctaggg cagatcgcag tctttttcgg 3267781 cacagggcag ttcgtctaaa agccagggca gcggccttag gcgaaagcgc cggcaaagct 3267841 gcttaaaacg cggtcgtttc tctatcacag agcgttttct gaaagccggt cttcatggaa 3267901 aaagggaaag ggagtccgtc cccttccctt gtccgctttc attatagcgc ttctattcga 3267961 aagaaccaag tcaggtcctt tttcagctat aaattaaaga cctttttttg cgatgtaagc 3268021 tgcaaggtca acaacgcggt tagagtagcc gctttcgtta tcgtaccaag agattacttt 3268081 taccatgctg ccttccataa ccattgtaga aagagcatcg attgtagaag agtttttgtt 3268141 tccgttgtag tcgccagaaa ctaatggctc ttcgctgtag ccaaggattc ctttaaggtc 3268201 gccttcagcc gcttctttaa gagctgcgtt tacttcttca gctgttactt cttggttcag 3268261 ttcagcaacc aagtcaacta gagaaacgtt tggagttgga acacgcattg ctccaccgtt 3268321 cagtttgcct tttagttcag gaagaactag agaaactgct ttagcagcac cagttgatgt 3268381 tgggatgatg ttttcagctg ctgcacgcgc acgacggtag tctttgtgcg gaagatcaag 3268441 gatttgctga tcgtttgtgt aagagtgaac agttgtcatc ataccgcgtt tgatgccgaa 3268501 tttatcgtta agtacttttg caaacggcgc aaggcagttt gttgtgcaag atgcgttaga 3268561 gataacatcg tggttagccg catcgtattt atcttcgtta acacccataa cgattgtgat 3268621 atcttcttcg ttagcaggag cagagatgat tacttttttc gcgccagctt ctaagtgttt 3268681 cgcagcgtct gcgcgttttg tgaagaaacc agtagattca actacgattt caacgccttg 3268741 tttgccccag ctaagtttag caggatcgcg ttctgcagaa acttcaattg ttttgccgtt 3268801 aacaacaagg ttgttaccgt caactgaaac ttcagcgtct aattttccgt gtacagaatc 3268861 atattgtaaa aggtgagcca gcatgttagc atctgttaaa tcgttaaccg ctactacctc 3268921 aacttcagga ttgtttaatg ctgcgcggaa tacgttacgt ccaatacgac caaaaccgtt 3268981 aataccgact tttactgcca tgattgtttc ctcctttaaa taagtgagag atatttatat 3269041 tgagggatta ttcatccctt aataacttct ttgcggctcc ttcgtctgtg acgagaaccg 3269101 tgttgcgtgg ctttttaaag taagcctcga tcgcttcggc ttttgatgat ccgcccgcta 3269161 ccgcaataat atcggggatg gcgtctatgt catccagctg cattccgaca gaatgcactt 3269221 tgtgaaccac ttcgccgtcc gcgttaaaat agtagccgaa cgcttccgtc accgcgtcgt 3269281 tatcatctat tttctttaaa tcttctaaag gcgtgtttct gcgctgagcc atagttttag 3269341 cttcgccgat tccgtgaacc agcatactcg ctgatttaat ggtgttcagc acctctttga 3269401 cagaaggctc ttcaataata gatgaatagg cgccttgtga cagctgtccc ggaacaaaca 3269461 aaagccggta agtgcctgaa gccttctccg ccatatgcgc gcatatggtg ttcgcctggt 3269521 ttttcacgtc ttcgcctaaa ccgcctcttg caggcacaaa caaaagctcg cggtttttag 3269581 aatccggcgt catcatttcg gcgacagctt caattgtcgt accgccagtt acagcgacga 3269641 tatttttgcc tgaaaatctt tttttcatac atgcgacagc cgctcttccc atttcttttt 3269701 tgacccatgg ggattgatcg ctgtctccgg atacgataat ggcatccttt agatttaaac 3269761 gttcttttaa tgtcttttcc aaaagagtca aacctaaaac atctttcatc gtatcttcca 3269821 aaacagaaag cagttcatag ccctcttctg tcaatgtcat gccgtttgtc ttaatatcga 3269881 ccaggttctg ttcctttaaa aactgaacct cgcccctcag cacacgctcg ctgattccga 3269941 gactggcaga caggcttctt cgcccgatgg gttctgtcag cctgatatac tgcaagattt 3270001 caaacctctt ttgcataacg agcagaagat caggcaataa ttttttttga gcttgtatta 3270061 actggttcat gactcaaacg ttccttcctt ttttgctgga cattatatgt cccgctatga 3270121 caaaaaacgt cccgtcatag ccaaaaaaaa tcatttctgc tttctttaat tattttaaca 3270181 gggtggaatt gtttattcaa ctgttaagag ccaattcatc gacaatattc gcagagtttt 3270241 catgccgcgt cgttttatcc agcaatattt tatcctatat atctttatct tatacagaaa 3270301 gcgccaaatg gtgcatccca atataaacag cccttcccgt agaaagggct gtttcattaa 3270361 agcgttttca ttttatccaa agcttttcaa tttcctcgag cgatttgttc ttcgtttctg 3270421 gacagatcgt aacgacaaac aggaaacaaa ggatgttaat caccgcaaag atccaaaatg 3270481 tataggcgag cccgaaagaa tcgatcatca ttggcacaaa ctgtccgatc gcccagtttg 3270541 ctccccataa aaagatggtc gcaatgcccg cggcccgcgc acgcagatgg ttcgggaaga 3270601 tttcagaaat cataatccat gtgatcggtc cgaccgagac acagaaagca gcgacaaaac 3270661 ctaatataag gacgatcatc atgatcccgc ttgttaactc aaaataaaac gacgtcccga 3270721 ttaaaatcat aaaaatagcc ataaaagcag aaccgatgga catcagtttt tttcgtccga 3270781 ctttatcaat cagcaacacc gcaataacgg taaaaataac ttctacaacc ccgacgatac 3270841 aagtcgtcac aaatccggcg ttttgcccga atcccatcat tttaaagatt tccggcccgt 3270901 agtaagtaat cgcgttcatg ccgatgactt ggttaaacag cgccagcagg attccaatga 3270961 caagcgcctt tctgagaccc ggcttaaaca gctgggagag cgaccccatt tgttctattt 3271021 ttaaagagtt ctcaatgttc tttaattctt cttttgcaac agtttctcca ttaatacgtg 3271081 tcaggatctt taaagcttca tttgttttgc ccgctttcgc cagccatctc ggactttccg 3271141 ggacgacgag caggacaagg aaaaaaatga cggatggcac cattccataa gcaagcatcc 3271201 atctccagcc ggtgtgcacg ccccattcgt atgttccgga ccgctgcaca gctagattaa 3271261 taaagtatgt tgcggaaata cccagtatcg taaagagctg atataacgaa gataaacttc 3271321 cgcgtatagc gggcggtgcc gcttctgtaa tatacgtaac agagagcgat gagcccatcc 3271381 cgattcccag ccccccgata atccttgcaa tgattaaggt ggacacgtct tgagaaagcg 3271441 ctgaaacgat tgctgatatc gcaaataaca aagcggctgt cattaaaatt tttctccggc 3271501 cgaatctgtc acttaaaaat ccggatatcc cgacgcccac aactcctcca atcataatgc 3271561 ttgaaatgac aagtccctcc ataaacggac tcaggctgta taaatctttc agaaaaccga 3271621 tggcgccaga aatcactgcc gtgtcatagc catacaataa gccgccaagc cccgccgcac 3271681 atgagatcaa aatgacaaat cccattgaat ggcttcttgt tacaggaaca tttggttcta 3271741 attgagttgg agtattcttc atttccctgc cctcccgaat gttgagtaaa gcgttttcat 3271801 ttaaaccttc aattgtacgt acttatatta aaatttaacg aaaattacat ttaattagta 3271861 cgtacaaata tagaataatc ttgtttgcat tttctgtcaa tgttttctta caaagaacgc 3271921 tgtgatatac tgaaatttgt ccgtatacat tttggaggaa tggatatgtt accaaaatac 3271981 gcgcaagtaa aagaagaaat cagttcttgg attaatcaag gcaaaatact gcccgatcaa 3272041 aaaatcccta ccgaaaacga attaatgcag caattcggcg tcagccggca taccatccgc 3272101 aaagcgatcg gagacctcgt atcacaaggt ctgctgtaca gcgtgcaagg cggaggcacc 3272161 tttgtcgctt cacgctctgc taagtcagcg ctgcattcca ataaaacgat cggtgttttg 3272221 acaacttaca tatcagacta tattttcccg agcatcatca gaggaatcga gtcctattta 3272281 agcgagcagg ggtattctat gcttttgaca agcacaaaca acaacccgga caatgaaaga 3272341 agaggcttag aaaacctgct gtcccagcat attgacggac tcatcgtaga accgacaaaa 3272401 agcgcccttc aaaccccaaa catcggctat tatctgaact tggagaaaaa cggcattcct 3272461 tttgcgatga ttaacgcgtc atatgccgag cttgccgcgc caagttttac cttggatgat 3272521 gtgaaaggcg ggatgatggc ggcggagcat ttgctttctc tcggccacac gcatatgatg 3272581 ggtattttta aagctgatga cacacaaggc gtgaaacgga tgaacggatt tatacaggcg 3272641 caccgggagc gtgagttgtt tccttctccg gatatgatcg tgacatttac aacggaagaa 3272701 aaagaatcaa aacttctgga gaaagtaaaa gccacactgg agaaaaacag caagcacatg 3272761 ccgacagcca ttctttgtta taacgatgaa attgcgctga aggtgattga tatgctgagg 3272821 gagatggatc ttaaagtgcc ggaggatatg tctattgtcg ggtacgatga ttcacatttc 3272881 gcccaaatct cagaagtgaa actaacctct gtcaaacatc cgaaatcagt gcttggaaaa 3272941 gcagccgcca aatatgtcat tgactgctta gagcataaaa agccgaagca agaggatgtc 3273001 atatttgagc ctgagttgat cattcgccag tccgcacgaa aactgaatga ataaaaaaag 3273061 caatgtatgg gtctccccgc tacattgctt tttttatagc tgttatctgt ttttccaaac 3273121 gtcagcgatg atttcaaacg aacgcattct gtctgcgtgt tcaaaggttt ctgagttaac 3273181 cataatttcg tcagcctgtg tcgttttgac gaaatcttca agcttcgcct tcacttcttc 3273241 cggacctccg acaatcgtgg agctcagctg ctcattgacc atcgcttttt catacgggct 3273301 ccagatttgg tccatatcct caacaggcgg tttaagctgg ttaggcgtac cgcggacaag 3273361 atcaagaaac ctttgataat gggaagtcgc aaggtgctgc gctttctcgt ttgtatctgc 3273421 cgcgataatg gtgacaccga ccatcgcata cggttcgtcg agcacgtctg acggcgtgaa 3273481 ggaattgcgg tacagctcca aagcgggaac cgtattcgcc ggtgagaaat gggccgcgaa 3273541 cgcaaacgga agaccaagtt cgccagccag acgggcgctg aagccgcttg agcccagcag 3273601 ccaaatcggc acatctatgc cctctccggg aatggcgcga acttgattgc gcacatttcc 3273661 tgacggttta aaataattgc gcagttcctc taattgttct ggaaaatcct ccccgctgtt 3273721 gatgtttctg cggagcgctc tggctgtcaa ttggtctgtt cccggcgcac gtccaagccc 3273781 cagatcaatc cgcccgggat acagtgtttc cagtgtgccg aattgttcag caatgactaa 3273841 tgaagagtgg ttggggagca taatgccgcc ggaaccgacg cggattttct tcgtgcctcc 3273901 ggcaatatgg ccaatcaaaa ctgcggtggc agagcttgca acaccttcta tattatgatg 3273961 ttcagcaagc cagtaacggt gatagcccca ttcctctgcc cggcgcgcca agtccatgct 3274021 gtttcggaat gattctgcaa tcgttcctcc ctgaacaacc ggagataaat tcaagacaga 3274081 aagcaaggta tctttgcgtt ggttgttaga catattgttc tcctttgcaa atgtgttatc 3274141 agtaaacagc ccaaagctgt caggtcatga ttgaaagaac ttctatcaca ccataacaca 3274201 actgcattca ggaataaaag aatttgattc gatgaaattc gaacaatata aaacgaacgg 3274261 tttggaacat tattctgctc caaacaactc cttagccatc tcaataaaga gcttagccgc 3274321 cagagaagcc tcctttagcg acggaacagc aagctgcaca tcacggtata cctgcgggtc 3274381 caattccctg gtcaccacat gctctggcag cggcatcccc gacatggaca tttctgataa 3274441 aatggccagg cccaggcctt ctctgatcat actgatcgag gtgttgatgt tatagaccgt 3274501 gaaagctggg tgcagcgtag cacccgcctg cctgaacata tcgataaatg gtgattcata 3274561 gccgccgtca cagacgatca tcggttcatg gtcaagatct ttcagcgtaa tggctgaatg 3274621 actggcaagc gggtgatcgt ccctgagcac gacagccatt ttgtcttttt tcaaatgaat 3274681 gtactccatc tcctctgttg gatacagaag aatcccaaca tctatcatcc gcgtatgaag 3274741 ccactccttg acttcattta cagttccctc gtgcagcacg agctcaagtt tcggatattt 3274801 ttgtttaaat tcactgatca gcttcggcat aaaataagcc gaggcagttg agaatgtgcc 3274861 gatatggatc gttcccagtt caagcccttt ttccgctgct gctacctgct caactttttc 3274921 aatgcctttt aagacttctc tgatgtgtac taagatctgt tttcccgtat ccgtcagcat 3274981 caggccattg cggcggtcac gaatgatcag ctttacatca agctcagctt cgatcgcaga 3275041 aatcgcatgg ctgacagccg gctgtgtcat gttcagcgcc tgacccgctt ttgtaaagct 3275101 tcccgtttca gctattttca caaaaacctt taattgagta atggtcataa caatttactt 3275161 atgctcctta taaaaaagat tcattttatt tatcttatgt tctaccgtat catatgatgg 3275221 aaaagttcta caaggagtga atgaacaatg aagcagctcc caaaaacgcg gacagctctc 3275281 ctgctcgcat ttctcgtcat catgtggggc gtcaattggc cgctgtccaa agccgcgctc 3275341 gcctattctc cgccattatt gttcgcgggc atccgaacgc tgatcggcgg gcttttatta 3275401 gtcatagtcg cactgccgcg tattcataaa ttacgcttaa aagaaacgtg gccgatttat 3275461 cttgtttctg ctcttttaaa tattacatta ttctacggcc tgcaaacgat cgggctgaat 3275521 tatcttccgg ccggcctgtt ttctgcaatc gtcttcttcc agcctgttct gatgggtgta 3275581 ttttcttggc tgtggctcgg cgaatccatg tttgtaatga aagtgattgg cctcatcctc 3275641 ggttttgcgg gagtagccgt cattagtgct gcgggctttg gcgggcatat ttctgtcatt 3275701 ggggttctgc tggctctcgg ctccgcagtc agctgggcgc tcgggacagt atatatgaaa 3275761 aaaacaggca gccgcgtcga ttccatctgg atggtcgctc tgcagctgac gatcggaagc 3275821 gtgtttctgc ttatctccgg cttttggaca gaaagctttt cggcgatcca atggacagct 3275881 ccgtttatta cgagcctgct gttcatctcc gtattcgtta tcgcactcgg ctggcttgtc 3275941 ttttttacgc ttgtcggttc aggagaagca agcaaggtcg catcttatac ttttttgatt 3276001 ccgctcatat caatcgtggc cagctccatt ttcctgcatg aaccgctcac ccttagcctc 3276061 ttggcagggc tgctgctgat tgtcacgagc atctgtctcg tgaatacaaa atcaaaagcg 3276121 cagaaagctg cggcgattgg tataaacgag aaagctgcac aataataaaa accctcttgc 3276181 cggatgcggc aagagggttt cttatttact gatgcttgcg tcctttgacc aaatatgcaa 3276241 ctgtaatcaa aaggtagatc gccgcagtaa tgccggtaat gacaattgat gttgtcatga 3276301 tgaccccgat cagaatggcg agtaatgcca caatcgcaaa ccatgtcgtg tacgggaacc 3276361 attttacata ataggccggt gtttccgttt gctgttttct cgattttaaa tgagcgaatc 3276421 cgatgatcag ccaaatgaat aaaacggtat atcccaatga tcccattaaa taattaaatg 3276481 tttggcttcc tgcgaacaga gaaatcaata cgccaatata gagagaagaa gtgcacatca 3276541 gaatcgcaaa catcggtacg tttttcgatg aaagcttcga gaagaccttt ggaagccttc 3276601 cgtcacttgc ctgtgtatac aaaatgcgtg atgatccgta taaacctgaa ttcatagaag 3276661 aaatgatcgc cagcaggatg actgcattca tgatatgatc cgcgcccgga atgcctacca 3276721 ttttaaagac catcacgaaa ggactttccg gaacggaatt gacttggttc catggaatca 3276781 ggctgacgat gatgaaaaac ggcagcaggt aaaacgcgac aatccgtgtc agtgtgctgc 3276841 ggacagcttt cgggacaacc ttttccggat tttttgtctc tgcaagcgtt acaccgataa 3276901 tttctgtacc gccgtaagag tagatgacga caagcatcgc cgtgatcagc cctgtgccgc 3276961 cgtgcgggaa aaatccgccg tggtctgtca ggttggaaaa tccggatgct gtatgatcac 3277021 cgaatgatac aaataagagc agcaatccca gaataataaa gataataata acggtaatct 3277081 tgatcattgc cagccaatat tcagtttcgg cgaagatttt aacagaaagc aagtttacaa 3277141 tcgtgacgat aagagaaatt cctaatgcca acacccagat cgggcagccc ggcagccaat 3277201 attgaatgaa aatcgcagct acaacagctt cagccgcaat gttaagcacc cacattttcc 3277261 agtagatcca gtccaaaaag taagcagcgt aatttcccaa tacctgctgg acaagatcac 3277321 ggaaggttct ggcgttacgg tttcgaacag ccatttccgc cagcccctgc ataataaaca 3277381 gcaaaataat cccgccgagc aggtatgcga taatgacaga tggccctgcc acatcgatcg 3277441 ctgagctgct ccccttaaat aaacctgcgc cgattgctcc gcccagcgcc atcatcataa 3277501 tatggcggga cgtcatcgtg cgttttaacg tttgattgtc gtttttcatc ctcttctacc 3277561 tctccttctc gttttcaaaa acaaaaaagc ccgccgtctc ctacctaatc taatagataa 3277621 agagacgacg agccttcggc tgaccgcggt accactcttg ttgattcttc atgaagaatc 3277681 ctgcttttga cctgtaacga aggttagccg ttaaaacata gggaatattc aatctattcc 3277741 gttccgtctt accactcccg ggcgagttca aagaagaatc aggctgcgtc gcaccacccc 3277801 gcagctctct gttctgatca ctttctttta ctgctcccaa tctatgtgtt ttagttttct 3277861 gaaaaactca aattttatga tctgaatata ttaacataat atacgtgctt ctcttttaac 3277921 tgtcaataac ttcagagaaa aaagaaactg ttattttgtc ccttttcgaa tggctttcca 3277981 aaaggattct gactcgtttc ctaatgcgta aactgaaaca cctgctattt tatattgctt 3278041 tgccagatgg cttttcgttt gaacggtttt ttcgttttca taccacacga catgtttatg 3278101 cttctttttg tcaacataag aaaacgtcat cgagcctgat tttttgttga atgccggctt 3278161 tgctttttgt tttttgatga gggatttgag ctcattccat tcccttattg tgctggtact 3278221 tccgtctttt acatcccagt catagccgta cgcagggatt cccatgatga ctttattggc 3278281 tttgatcttt ttgactgaaa actgcagaga gcttttgatc cagtttgtgc ttgccactga 3278341 ccccggctca ccccaaatgc cgtgttcatc gtaggtcatg acttgtacga agtcggcata 3278401 tttgccgatt ttcgcataat catacggcca gctccagtca tcatttttat catcggcgct 3278461 tttggccgga acggatacca ttgttttaat atgtttctta ttcaaagcct gtgagacata 3278521 ttgaatgaag ttcgagtatg cagcgcggtc ttctggattt actgcttcaa aatcgatatt 3278581 gattccgtaa tatgagtgct ttttggccag tgtaattaac tgatctgtga atcgtttttt 3278641 cgctgtttta ttgctcatga cccgactcgc taaatctccg tcaaaatcat aaatggcatc 3278701 attatagttt gaaatgacag cccatgtctt gatttttttc tttttcgcat atgtcagctg 3278761 cttagttggg gcatcgccaa tgatttgtcc gtttttttca aacgcaaatg tatcggttgc 3278821 gatggcattc atgtatgtat gatatttcgt aagagaattg tatgaagccg tatccccagt 3278881 cgtgtagcct actgtcatac cggctgcctt cgcttctcct tttgtataca taaacagaac 3278941 aatcgcaatc gccagtgaaa ccgctatgat cagccatttt ttcatcgcat ttcctcctgt 3279001 atcaagtcat actcttctca tcggccaaaa aattggaagt tgaagttttt tcaagcaaaa 3279061 agcccggcat atgcctgccg ggcttcctga gttcagcggt cagagacgag aatatatgct 3279121 gcctttactg gtccatgcac ccccacaact aaatccattt caatgtcggc tgagttactc 3279181 ggtccggtaa tgtagttgat acatgaagga acagtgacac cgttcgcaat gttttggcgg 3279241 atgatatcac tggcttgtgt cattctcggt acaatgcttg atttcggcac gatcgcaata 3279301 taagtcgttg gcaaaaggct gacagagcgg ccgatgtctt ttgaggagaa gaggacaacc 3279361 gtccccgact cagccaatgt aatttcgctg aatgtaatcc ctacattggc ttgctccgct 3279421 tttttaatat tttcctcgcc tttgtcagca tcccactccc agaccggcgt tccttcactc 3279481 ggccagtcct tggtgagcag gcttttcagt ccgtattctt caaagcgggg gtccttcgga 3279541 atgatgacag ggcctccaga aaagcggctg acttgctcgc gcagggcatc gtaaaggccg 3279601 gttgaatccg tttcaatcag ctctgtatgg attttgacac aatggttttt gagcactgtg 3279661 actaagtcat ccgctgaata accttcaagt gttttatatt gcggctgatg cgcccattca 3279721 gggactgcca cgcctcctgt tcttcgttca cggcccaggc tggatgcgat tcggtttaaa 3279781 aagctctctt gattctgaat ggttcccttc gtcatcactg ctcctccttc gtgcgttcac 3279841 ttgtttctct gtccgcaaac cagtctctga atctcgattt atgcggtgcc gggaagtcgc 3279901 gaatctgggt ccaattttta agcgggccgg gccctttcga aattttttcg tcctctgtaa 3279961 aaggcgtcat ggcggccggc gcccattttg agcccatttt gtaaagcgat aaggaggatg 3280021 cgccaagtcc gaatgctttc attgcaagct tttcactgat cggcgccctg ccttcttttt 3280081 cgacgatatt ctgacgatgc ttgagtagca gctcatgaag cgggattttg accgggcagg 3280141 cttctgaaca agcagcgcac agtgaagatg cgtacggcag ctccttataa tcgtcataac 3280201 cgccgagcaa cggtgataaa acagctccga tcggccccga gtagattgag ccgtatgaat 3280261 gtccgccgac atggcggtac acaggacaga cattgataca ggcggcacag cggatacatt 3280321 gcagcacaga ctggaattcc gttccaagga tattggatcg tccattatca acgatgacaa 3280381 gatggaattc ttccggaccg tccacttcac cttccagctt cggacccgtc aaagctgtaa 3280441 tatagcttgt cagccgctgt ccgacagcac ttctagtcag catgctgact agcacttcaa 3280501 attcagaaaa tgacgggaca atccgctcca ttcccatgac ggtaatttgt gttttcggca 3280561 aggtgctcac aagccgtcca tttccttcat tggtcacaag gctgacggaa cccgtgtcag 3280621 cgatggcgaa gttacagccg gtaatgccga tatccgcttc cagaaacttt ttccggagaa 3280681 tggcgcgcgc atgcatcacc agctcttccg gtttttctgt atgttgatag tccagtcttt 3280741 ctttaaacac atcgcgtatc tgctctttat ttttatgaag agcgggcgct acgatatgtg 3280801 acggcggatc gtgatcatca atctgcaaaa tatactcgcc gagatcggtt tctacgactt 3280861 cacagccttc cttctccagc acctcattca gattgatttc ctctgtgacc attgatttag 3280921 atttcacaat tttcttcccg ttcttctttt gaatgacatc ccgaatatag gaagacgcct 3280981 cttccgctgt tttcgcgaaa tagacatgtc cgcctctttt cgccacattt tcggcaagct 3281041 gtccgagata gaaatcaagg ttttcaagga catgctgcct gatttcctct gataatgagc 3281101 gccactcctc ccagtttccc agttcttctg ctgcctctag gcgccgcgtc cgcagacgct 3281161 cctgtgcacc tgaaacagcg cctctcataa attcattatc aatcccctgt gatacccgct 3281221 ctttaaaagc gtcagtaccg attttcatcg ccatgatcct ttccccctct gaatccagtt 3281281 ttatctgctg ttgagcactt cggcgatgtg catcactttg acattcttat cttttcggcc 3281341 aagccgtccc ccgatattca tcaaacagcc gcagtcagca ccgatcagca cctctgctcc 3281401 cgtttcctcc acacattcga ctttttcatc gaccatctgc tcagaaatct gcgccatctt 3281461 gactgagaac gttcctccga atccgcagca gttatgtttg cccggaagct ctgtaaactg 3281521 caggcccttc acatggctca acagcttcat cggctccttc cgaacaccca gcagcctagt 3281581 catatggcac gacgtatgta aggtcgcttt tgtatgaagg gtcgcgccga catcctctac 3281641 cccaaggacg ttcacaataa aatctgtcag ttcatacgtt ttatccgcca gctttttcgc 3281701 tttatcggcc catttcggat catcctgaaa caggtgcgga tactcccgga acatcgttgt 3281761 gcaggaaccc gaaggactga caacatattc ggaatcctga aacgtttcga tcatccgttt 3281821 cattgctttt ttggcgtcat gtacatagcc gctgttgtaa gccggctgtc cgcagcaaat 3281881 ctgcccttct ggaaaatcaa cctcgcaccc aagccgctcc agcagctcaa ccgttgcttt 3281941 tccgacattt gtttgaaaca tatcaacaag acaagtgaca aaaagtgaga ctttcatgat 3282001 gaacccctct ctcatcccca atatatgatc aggtcatctg atgacctgag ttaaaataac 3282061 tatatgaata tcgtacacta ttctgacaat ggaaggaaag agttttctag ggatattttc 3282121 atttgtggca tatcaaaaac actcccgatc tcccaggagt gcagtatatg gttagatcca 3282181 gcccttttcc tcagcgatgc tggcggcttc tgtccgattt ttcgcattaa gcttttggat 3282241 gatttctgag atatagtttc gaactgtgcc ttgagataaa tagagctcca gcgtaatgtc 3282301 ttttgttgtc ttgcctaaag ccgcaagcct cagaatttct tgctctctaa cggttagcgg 3282361 attttcgtct cgcatcatat taaacgtcag ctcagggctg aagacacgtt ttccctttac 3282421 acattttcga atggcatcgg ccagatcgtc aatttcaccg tctttcagca gatagccatg 3282481 tgcaccggcc tttacggcgc gttcaaaata tccggggcgg gcaaaggtgg ttaaaataat 3282541 gaccttgctg acgcagcctt ttttcattaa ttcctctgcc acattcagcc cgcttcgaac 3282601 cggcatttca atgtccataa tgcatacatc cggctccagc ttcaaaatag catgtagcgc 3282661 ctcttccccg tttaatgctt gtccgatgac tgtcatatcc tcttctaaat caagcaaaga 3282721 tcccaaagcg cctaaaagca ttcgctggtc ctcagcaata aacagacgaa tcattctttt 3282781 cgtcctccaa tcattctgct tttttaataa gcggaatcgt cagtgccaca accgttccgt 3282841 tatggtctga aaccgttaat cccccttcaa tgagcatgag ccgttcttcc attccccaca 3282901 ggccattccc aaacattttc tccttcggcg ctccctttcc gtcatcccgt attacgatcc 3282961 tcattttgtc agcaaattga gaaatggtga tggcacagtg ggttgctttg ctgtgcttga 3283021 taatgttagt cacggcttcc cgcatacaca tactgataat attttgagtg acgggagata 3283081 tcactgaaaa gtcgtcggct ccttcgtatt gaaaggtaat gttccccgct cttaatatgt 3283141 gctgaatgtt tacgagctcc tctgttatcg tgaccgttct catatcagaa accagctctc 3283201 gaacttgctt gagtgcggag cgtgaactgg tttccatttc ttttgcctca agcttggtcc 3283261 gttctggatc agatgcagcc agccgctgaa tgagctggct ttttaatgta agcagcgaca 3283321 gggtgtggcc aagagtatcg tgaagatcac gggcgattcg aacacgttcc tcccttttag 3283381 agagttcttt tatctgttcg ttggcttgtg caagcttagc ttcaagctca atcctccgaa 3283441 acatagaacg aattccgaat ggagaaatga gcataatgac gagaaacggg agaacagaaa 3283501 aaagctcccg aagcgagacc gaattcgcga taaattggta taggcatgga aaaagcagta 3283561 taaagattaa agcgcagaac gcacggttaa aattcgtttt ctctttgtaa taaccaacaa 3283621 agtttgccgg aaaaaaacct aagtatatat aggtgatatt gtaaaacaca ctatacatca 3283681 aaataaccgc catttgcacg ataagccaat atgtaaacga agctttgccc acgctgcaga 3283741 ataactggcg atatgccgct acaaaaagga gcagcatacc atatccgatc ccctgtttga 3283801 cccctgattc ttttaataaa gagaggaacg gcataatcgt atacaccaga aagatataag 3283861 ggaaaaaccc gaattccttc gggaaaatag atattgcctt tttcatgtat tacaccgctt 3283921 cttgttttct tcttatatat ttagatagta gcatgaagag catcatataa gcgattaata 3283981 tcagaatatt tttccaagtc ggactcccac cccggacaag ttcccacgct ccgctcccga 3284041 aatgataaga cggaagccac tggccaatgc tctgcatcat gtcaggcatg acctcaaacg 3284101 gcatccacat ccctccgcct aaagccagca gcatataaag cacattactg attccggccg 3284161 ctgtttctac ttttctcatg aggccgatta gtgtgcctaa tgctaaaaaa ggcaatgcgc 3284221 caaacaaaat ccacagtccg ctcatcatcc attcaaacgg tgacaaggca atatcattga 3284281 tgattgcgcc gaacagaaat atgacggtaa ttgataaaac gtgaatgaca ctttggccga 3284341 tcatctgagc tgataaatag atatgatccg gaagaggcgt aaggcggata aaggcggccc 3284401 agccttgtga ccgttcttgt accattcgga tgccaagcgt catgatagag gaacccatca 3284461 cgctgaagac tgtcatcgac atcaggtaat gggcttccca tgcacgttga tcagggacgt 3284521 tggtattcac tacatttgta aagaaataat aaaaggcaat cggcatgatc agagaccaaa 3284581 gcacaaagta cttgttccta agcacccttt tcatttcagc gatgctttgc ttttgcagca 3284641 cgttcactca catcgcctcc ctgttgccgt cagccagctg gcgaaatgcc tcatcgagcg 3284701 ttgcttgctc aattcgaata tcccgtgcat gtatgttttc ttgaaagatc agcgccaaca 3284761 ctttgtctgt atttgatgtc tggatgatgg ttctctcatg ctcgtggatc actctctcga 3284821 cttccgggtg acaagacagc ctttccaatg attcacttga atgaagcgta aaggaaacag 3284881 actgtttttg aattcttgag cggatttgca ttggtgagcc gtctgcaaca agctgtcctt 3284941 cagtaaaaaa taggattcgc tgtgcggcat catctgcttc ctgtaaataa tgagttgaaa 3285001 aaataatcgt ttttccttgg tccgacagtc cgtgaatggt ctgccagaat cggtgtcttg 3285061 atgaagtgtc catgccgact gtcggttcat caagtataag cagctccggg ttcccggcaa 3285121 gagccaaagc aaagctcaaa cggcgttttt gtccgccgga taatttttct gctcttgttt 3285181 tcaaatcttc tttggtgagt gctgttaacg aaacgagttc tttcatggac aatggattcg 3285241 gataatagct ccggaagagt tcaaggattt catccacctt aaggcccggc atgacactta 3285301 cttcctgaag cattacacct attttttcac gaacctgttg atcatcggga acccggttaa 3285361 atagtttgat ttctccctca ctcggtttca gcaatcctaa tatcatcgag acgacggtcg 3285421 tcttccctgc cccatttggc ccgagaatgg ctgcaatttc tcctttttca atactgaagc 3285481 tgatgttgtt tacagcggtt tttcgctgga aatgttttgt cacgttgctt actgttactg 3285541 cttctttcat cacatgagca cctcctgatc gtttacattg attgtaaaat gacggagaag 3285601 acgatgttag tatggggtgt catgatgatg gagtgacaaa tgtcattttt ttctcacccc 3285661 ggtgtctagg caatcctcct cctgcatctt ccaattcatc catcttttct atctcccatg 3285721 tcctctttct tttaaactgc tgtgacattc atagaaagat acactcttca aaccatccga 3285781 gtgttatgat agaaatattg aactttatat tactttccgg ctgaaaggag ccaatcatga 3285841 acgaagcgat tttgtctaga aatcatgtga aggtgaaagg cagcggcaaa gcatctatca 3285901 tgttcgcacc tggttttgga tgcgatcaaa gcgtgtggaa tgccgtggca cctgcctttg 3285961 aagaagatca tcgggtgatt ttatttgatt acgtcggttc gggacattca gatttgcgcg 3286021 catatgacct gaatcgttac cagacacttg acggctatgc ccaggatgtt cttgatgttt 3286081 gtgaagcttt agatctgaag gaaaccgtgt ttgtgggtca ctccgtcggg gccttgattg 3286141 ggatgcttgc atccatccgc cgcccggagc ttttttccca tctggtgatg gtggggcctt 3286201 ctccttgcta tttgaatgat ccgcctgagt attacggagg atttgaagag gagcagctcc 3286261 ttggcttgct ggagatgatg gagaaaaatt atatcggctg ggcgactgta tttgcggcaa 3286321 ccgttctgaa tcagccagat cggcctgaaa ttaaggaaga gcttgaaagc cgtttttgtt 3286381 ctactgatcc tgtcattgcc cgccaattcg cgaaagcggc gtttttttct gatcaccgag 3286441 aggatctttc gaaggtaacg gttccctctc ttattctcca atgtgcagat gatatcatcg 3286501 cacctgcaac agtaggtaag tatatgcatc agcatctgcc ttatagcagt ctgaaacaaa 3286561 tggaggctcg cggacattgc cctcatatga gccatccaga tgagacgata cagctgatcg 3286621 gcgattattt aaaagcacac gtgtgatata ggaacgaaag ggatagaggt gaccctctta 3286681 gatggacaaa caattgaatg atgcaccatg cggtttcctc gctttgtcag aagaggggtc 3286741 gatcatagct gccaaccgca cccttatcaa gattctggat tatgaaccgg agcaggttat 3286801 cggccagcac atgaatatga tgttgaccat tcccgcgcag cttttctgcc agctttattt 3286861 ttttccgctt ttgaaattgg agcatcacat cgaagaaata tacatttccc tgaaagcaag 3286921 agatggagaa gaaattcccg tccttatcaa tgctattgcg agacacgata gcggggcttc 3286981 tgtctttgat tgtgttctga ttccaatgcg aaagcgaaat gaatatgaaa atgagctgct 3287041 gatagccaga aatgaggctc aggaagcttt gcttgccaaa cagaaagcca atgcggagtt 3287101 agaaattgcc ttggaaacgc tgaaagcaaa acaagaagaa cttcttgaga tcaataaaca 3287161 aaatcaacaa tttaaattaa acaccaaaag agagcttgaa ctcgccagaa agatccagaa 3287221 aaactcgttg actgaaccga ttgtaaacga tcaggttcag attgactctt attacaacgc 3287281 atcgagtgaa ttgtcaggtg atctttacgg atattatcaa atcgatgaac accgttacgg 3287341 cattattatc cttgatgtga tggggcacgg aatttcatct gcattgatta cgatgtctct 3287401 tcatcctttg ttccagcgcc agatcacgca aggtctcagc cccgttaaag ttatgaagga 3287461 attggaccgg caccttcaca gcttgtttca aaatgatgag gaagcaagac attattgcac 3287521 tgctatttat ctcgagattg atatagcacg gcaaagaatt gattatgtca acgcagggca 3287581 tccgccggca ctttggcagg acgatagcgg aactcaacat ctgcttcacg cgacctcgcc 3287641 tccgatcggg atgtttgaag acttagagtt tcagtcaagc agcctttcat acacggagga 3287701 cggaagattg cttctgtata cggatggcgt gatggatcct acggcttcat gttatttatt 3287761 tgatttacta aaggatcatc ctgattcgcc aatcgctgac ctgaaggaga aaatccttac 3287821 atcactgcag catcaaaagg aagctcatca taagagtgat gacgaatgtt ttatattagt 3287881 tgatgtaaaa taaaatgatc catgagacat aacaatgatt tgttacatct catggatttt 3287941 tttgtttcag cgtttctttg gaatatgtcc tgactccgca tattgaaaca cctgcaagga 3288001 aggcagcggg tgtccattaa aatcaaataa agcttgatta tctacagcac ttcccccata 3288061 ccacttcccg gcgtcttcag ggtcgtattc agcagcatag ctggacgccc accctgaccc 3288121 gtatgtttcc cataacactt tgtttttctc tatctgtgtc ttcggcccga ctggaatcca 3288181 cgccggctcc cagtagaaaa caccaagtcc tgctttgccc gtattcgcca ctgcctccat 3288241 tacatctctt actgcagttg cctggccttg aacagaaatt ggatatggca acgtctgccc 3288301 gctttttggt gctgtatttc catgcccatc gccatcctca gcggtatagg tgtacgatgt 3288361 ctccgccacc atgacttttt tgccgtacgt attggcaaca gccttcagca cggaggtcaa 3288421 attttgtaat gtgccatgcc agaaaggata ataggagcta gcaaacacat cataatccac 3288481 tttgtttttg ctgagtgttt ctgcaataaa tgaatacctt ccagccgttt caggattggt 3288541 aaaatgcagg gcgaccaaaa tatttgaatt tgtctccctg accgctcggc ttccttcatt 3288601 aaataattgg cacatcttcg tccaatcagt ctcaccggca aatcctcctg ttgtttcatt 3288661 tccgacctga accatgccga tgtcaacgcc ttccttgatc atcttttgca ggctttgttt 3288721 cgtatactca tagagctttg ctttttttgc ttcaaagctg agattcgccc aggctttggg 3288781 caccttttgt ttcgctggat cggcccagaa atcagagtag tgaaagtcgg ccagcacctt 3288841 cattccgttc gctgtcgctc tttttccgat ttcgatggct ttttgaacat cattgtttcc 3288901 cccgccatac ccgttgccat ttgaatcata cgggtgattc cagatgcgga cgcgaacata 3288961 gttgacccca gcctgtttta aagttgtaaa gatatcctgg cgttttccgt ttgtattgta 3289021 aaaggtgaca ccgctgtttt ccaaagcaat aacgctggat acatctgccc ctttgataaa 3289081 atccttgttc atcccctcta cttttttaac aaaaagatcc tctgcccgaa gctctgacac 3289141 gtgcttctcc ttctcaatgg cagcggcata tcctgttgaa ctacatgcac tccacacgat 3289201 ggcagccgca aagaacattt tcactttgct tttcatgatt tcatcccccc aagacttagc 3289261 aagcgttttc attctataga aaaaagaatc cgcccatatc gagcggagca tcagcctaat 3289321 gtgtgtttac gacaattctc acttcatact tttccatcgt caggtcgcct gacaatatgt 3289381 ctcctgtcat tatgtccttc acactctgat caaacgtgac cagctgtttt tcttccgtga 3289441 aattcatgac aaaaatataa tcattgtcct gatcctgcct cgcttgtacg gagacgcctt 3289501 ttccgtgccg aaccggaaaa actggagaga gagacaggtc tgtgatcaga ccctcataga 3289561 aatcacgctg aaattgatcc tccaaacgcg cgccgataaa atacgccttg ccctgctgat 3289621 actcatggct tgtgaccgct ggcgtgcgcg cataaaaatc ttcttgatac accgcttcca 3289681 ctgaagctgt ctttacatca atcacggttg cataatcctt catttcatat atttggctgc 3289741 ggtagctgac agcgtttcga tccttcggat acagggtgtc cgtttcaaga ggctcaactc 3289801 caaatatagc ttgaagatcc ggatgccatc cgcctgtgta tgttaagtca tgctcattca 3289861 caaccccgct gatatacgtc atgactaagg tgccgccgtc agccgtaaac gcttttaaac 3289921 gggaaacggt gtcctcgctg attaaataca gcatcgggac gatcagcagt ttatatggtg 3289981 aaaagtcttg ttctttcgtg atgacgtcga cagggatatc gtgttcccag aatgtgcggt 3290041 aatgctgctg aagcgtttgc ggataacgtt ttgtcgcctt cgcaaacccc tgagcatcct 3290101 cgagcgccca atgattttcc cagtcatata aaatcgcggt ttgagccggc ctcttcgttc 3290161 cgacaacttc ggacagccgt tccaatgtct cgcctacctt ggccacttct tgaaagacgc 3290221 ggttcttcgg gctattgtca tgatccacaa ccgctccgtg taatttttct gatgaccccc 3290281 gtgatttgcg gtattggaaa tagagaacgc tgtccgagcc gtgggcaatc atttgcatgg 3290341 atgacagcag attcatgccc gggcgctttg ccttgttgac gttatgccaa ttgaccgcgc 3290401 ttggcgtaca ctccattaat aagaagggct gctgcttcaa gcttcggtac agatcattga 3290461 taaagccgac cttcatcgcc aaatcagctg tgctttccca gtcattgtgc cagacaggat 3290521 aagcgtccca gctgatggca tcgacatgct ttgcaaattt gctgtagtcg aggccctgat 3290581 acgggatcaa atccggtgtg tcagccataa aattcgttgt gatagggata tcaggcgtca 3290641 attctttcag cggaatgatt tcattttcat aaaacgaaat cgtttgatcg gtgacgaacc 3290701 ggcgccaatc taaattcagg ccatgcaagc cattttcacc gatcggcgaa gggctttcaa 3290761 tttgtgacca gtcattgaac gtatggctcc aaaaaggggt ccaccacgca tggttcaatg 3290821 tcttgaggct gttgtcatat ttcgatttca gccactcccg gaaagcatgc tggcataaat 3290881 cacagtggca atctcccccg tattcgtttg aaatgtgcca cattaacagc gccgggtgat 3290941 gtccgtatcg ttctgctaat aagcggttga tgtgccgtgt tttttctcgg tagactttag 3291001 atgtgaggca gtggttgtgc cttccgccgt gcagctgttt gacgcgggag gcattgacgc 3291061 gcaaaacttc cggataggtt tgcgacagcc aggccggacg ggctccgctc ggcgttgcta 3291121 atatgacccg gccgcctata ctgtgaatcc gctcaaaaat atcatccagc cattcaaatt 3291181 gatatacgcc ctcctccggc tcaagtgcgc tccatgcaaa aatgccgaca gaaaacgtat 3291241 tcgtatgaga aagcttcatc agtttgatat cgtcagctaa aatatcgggc cgatccagcc 3291301 actgatcggg gttgtagtct cccccatgga gcataaattt tgcttttgtt acgtgcgttt 3291361 tttcaagctt tgacatcaca ttctcctcct tgttctctta gcccttcgtt ccgcctgcgg 3291421 ttaatccgga cacaaaattc ttttgcagca taataaagat gacggcaacc ggtatgctga 3291481 taagcagggc tccggccgca aatgtcgtat agctggcccc catgacatca ttcactaaat 3291541 tgaatagacc gacgggcaat gtatatgatt caggcgttct caatatggtt gaggacagca 3291601 caaaatctcc gagcggaccg gtaaagccgt tcatggccac gactgccgcc atcggttttg 3291661 ataatggcag aatgatctgg aagaagattc tggtgctgct ggctccgtca atcttggcgc 3291721 tttcgtctaa atccatcgga atggaatcca tgtacccttt catcaaatac gtattcatcg 3291781 ggatcaggcc gccgatataa agcaagatta gcagccagtg gctattgatc attcccaaga 3291841 tttgcgccag cacaaacaag gcaattaaag ctgaaaactg aggaatcatc tgcagcaata 3291901 aaaagagcgt taaagcgtat ttcctccctt taaaccgaaa gcgcgaaaac gcataggccg 3291961 taaacgtcac acagagcaaa gaccctgcca ttgtaaacag gctgatcttc atagagttga 3292021 cataccactg cacatattga aggctttcct tgcccgcaaa taattccttg taatgatcga 3292081 atgtcggatg cttcggaatg atggatgtac tgattaagct gttgccggga ttaaagcttg 3292141 cgcctgccgt ccaaaggaga ggataaacaa tgatgaccgc cataaaggct agcaacaagt 3292201 aagagaaaag gagacggata tatcttctga ctttcatatc tgccagcata ccttatgcct 3292261 cctctttaaa agactttgtc tgtctgaact gccacaatgc gatggagata acaaatacag 3292321 ataataaaat ggttaaagcc gcagcaagtg aatattggct ggactgcatt gtcaatttat 3292381 aaatccatga aacgaggata tctgtcccgc cggctgttga tccggttaca gccggacctc 3292441 cgccattgaa tagatagata atattaaagt tattaaagtt aaacgtaaac tgagtaatga 3292501 taatcggagc cattgcaatg aacaccatcg gaagcgtgat gtatctcagc tttgaaaaga 3292561 cagaagcgcc atcaatcgta gctgcttcat acagatcgtc cgggatggat tgcaatacgc 3292621 ctgttgagac gagaaagatg tacggaaatc cgagccagcc ctgcatgaga atcaatgcaa 3292681 gcctcgacca attggcatct gtcatccacg gaagcggatc tatcccgaag aaagccaaga 3292741 tgtcgtgatt catcgcaccg aagctatcat taaacagtcc cgcaaaaatt aaaatcgtca 3292801 caaaaccggg aacggcccat ggcaaaatca gaatcgtccg aaaaaaacgt ttaaaccgaa 3292861 ggtctttctg gttaacaatg atcgcgagaa aaatccccaa ggtgacttgc agtgtggatg 3292921 cagcaagtgt ccaaaccacc gtccaagcca gtacatcaaa aaaagtcgac ctccaaatat 3292981 caactgtgaa aatatttgcg aacgtttgaa aaccgaccca atcaattaat tttgcaggag 3293041 gagaatgata caaatcatag tttgtaaacg ctaatgcaaa gctgaataag ataggaaaga 3293101 tcacggcgaa aattaaaata aacaaagatg ggccgctgac gacataagga tagccctcag 3293161 aaatgatatg ctggtattgt tcctttaagg aacttaatgg cttattttca tcacgctgtt 3293221 ttccgctttg gaacgcatcg cgaagattta cataatacac cgcaaggcca aagcaggtca 3293281 cgatgacagc aataatccct tccgccagca gaaaaacgga attatcccgc ggcacttctg 3293341 ttcccagtgt aaagattccc caaaacccca tattgagcag atctccaaag accgcaaaaa 3293401 acgatgcgcc taagaaaaga aagacaatac cttttatcca ttgcttgtta taaaattgcc 3293461 cgagtcccgg aatgatagaa agcaacaaag cgacttgacg atgctgcacc gttttcacct 3293521 ctcttacaat acaaatctag ctttctcttt attttccgct gtgctttgcc ttaatttgtc 3293581 ctttggccgt ttcagctgct tgatccaatg cttgtttcgg atctgccttc cctgttgcaa 3293641 ccgtctgtaa tgctgaatca gccggcgtcc atatttcatt catttccgga atatttggtg 3293701 ttggctctga gaaacgggat tgttcagtaa cagcccgtgc cgcctcgctt ttcataatag 3293761 ccgggtcatt ggctagggat ttcacagcag gaacttcttt cgtttcttca tatcgtgttt 3293821 tagaattttt ttcatttgcc aggaaaacgg ctaattcttg cgccagctct tcattctttg 3293881 aaaatgcact gacgttgtag cttttgacgc cgataaagga gctcatgttt ttcccatttt 3293941 ccagcttcgg cagtttcgta atgccataat tgattcctgc attcgaaaag gcttctacat 3294001 tccatggacc agaaataatt gcggcggctt ttccttctgt gaacagcgat tccaacacgt 3294061 taatcccttg ttctccaata atgccagccg ggaacaggcc atctttgtaa aacttctgaa 3294121 tcagcgccgc acctttgaca gctccttcat tattgattcc aatgtctgac gggttatagc 3294181 tcccatcttt ggcctttcca aaaatgtatc cgccatatcc gctcatcaca ctttctgcat 3294241 aataaatttg atcgaatagg gctaaaaagc caaatttgct gccgtcagca gtctttttgg 3294301 aatagtcgta ccactcttcc agcgttttgg gcaattcctt ttctgtgatg agatctttgt 3294361 tgtaaaaaag cacagtcgtt tcgaccgctt ttggcagtcc ataaagcttt tgatctacca 3294421 tttgagactg aatggaagcg tcagtataaa gtgattgaac gtcttttttg acatgtaatt 3294481 ccttgagtaa tccttccgtg acagcggttc cgatttggtc ccctggcatt gttaacacgt 3294541 cagggcctgt gccggccggt ccatccattc gcaaatcttc aatctgcttg gcatacggtt 3294601 tttcaacgac tttgaccttc acatcatgct ctttttcaaa tgcagccaca gcgtctttaa 3294661 tgccgttgct cttttcttta tcctcccata caacaagctc tgaccctttt gaactcgatt 3294721 tggcgctgct gctttccttt gggccgcaag ccgccaagga taaactgaca gctgcgcaga 3294781 gcatgaatac ggaacacttt tttgccattt tcattgattg tcaccctttc ggtaggaatg 3294841 aaagcgcttt aaagataata tagcatgcct gagaaaatgt gtaaacaaac tatttacttc 3294901 atagagtaaa tttttttacc taaataaaaa atgacttagt gtcctaagtc atccttaatt 3294961 catactcttc ctgacgatta attctgcgcc cacatataat gtttttaccg ttcttctctt 3295021 gtcctgcact tgttcaagca gtaattgaac agcgttttta cataattcat gtatatcaat 3295081 atgaaacgtc gtcagaggag gcgagacata cttcgcgaag ctgatgttgt tgatactcac 3295141 aatgcttacc ctgtttggta tggcaattcc tttttcgttc agggcttgca gacagcccac 3295201 tgcaatcggg tccgctgcaa tcataaaagc agtcggaagc tgatcgccta atgtgtcgat 3295261 cgctgctgac atcaggcggt agccgttttc tacagagaat ccgcgatgac agaaaatata 3295321 gcgctcgtcc agcatggctt tttccctcat ataggatctg aaggtttgtt cacggatgtc 3295381 catttcatcc tgattggtat tcggattttt gtatgtgccg ccgataaaac cgatgctctt 3295441 atgccccttc tcagtcagga tgtttaccgt cttccttgtc atttgtgcca aatcgggcct 3295501 taccgagtca aaatgatcgg gatcaggagt tgaatcgatg aacacgccgt tttcagtgag 3295561 atttctgagg aaagccagct cttcatctga aaatgtgccg acggcaataa acccttccgt 3295621 atgttcagga atgctctcga ttccatccgc tattttataa gtggtcatat cgacattgaa 3295681 tgctttcgcc agtttctcta cttctaatct catcgtttta aaatagacat cttctaattc 3295741 ttctttatct gtcagccaat ataaaaacgc aatatgtttc accagcggcc ttactgtttt 3295801 tttgcggtaa ttgagctttt ccgccgcttc atagattttc tcccgtgtct catcaggaac 3295861 agaaaggctt tcatcgttat ttaaaacgcg ggaaacggtt gagattgaaa atcccgcttc 3295921 ctgcgcgata tctttaattg tcgccattgt atctgcctcc attattcagc tcgcattgtt 3295981 ttagtaaaat attttacttt ctttttcaca aatgtcaagt gcacaaagcc ctctggctgc 3296041 catgtaaaaa gactgaacca tttgcggctc agtctcagtt gttcgtatca ttcggaaccg 3296101 gcggaattgc ccgggaaatg agttggttat tgcacatttt cctcgaaata tcccgaaagc 3296161 acatcttcca cattcgtcaa atgcgccagc atggcggctt ccgcctgtgc accgttcccg 3296221 gcagccacag cattgtaaat ccgttcgtgc tcctcataca gccgctgaac ggaggtcttc 3296281 ttggaaaaca gccagatttt cctcgtttcc ctcattgttt ccagcagcaa tgatgacacg 3296341 tgattcatca agtgtttaag aagttcattt tgagaagcgt ccgcaagcgc aagatgaaat 3296401 gcaaagtctg ctttctctcc cagctccccg tccgcttcaa tgctgcccat ttcctttagt 3296461 gcatcctgaa ttctttcgag atctgcttct gtcctttttt cagccgctag tgaagccacg 3296521 ccgatttcaa gcagttttct gacctcgagc agctgcttga cgtcctcttt tttcatcaga 3296581 agggcggctg agagcggctg agaaatttga ttgagctcaa attccttcag atacgtgcct 3296641 tctccctgtt tcatttcgac aagccccatc gcttttagcg cagaaagtgc ttcgcgaacc 3296701 gctgaacggc tgacttgaaa gctctcagca agcgcctgaa cagagtccag tttatccccc 3296761 ggcttcaatt cgccattttt gatcatatct aatagggcat ccgctacttc ttcatatatt 3296821 tttttgtttt aatctgttta tatttcaatg caattcaccc cgtaacttgt aggtctggct 3296881 gtttacgatc tattatactc tgttttgtgg gccgccaaaa gattttgact attttgtcaa 3296941 aaagtcttgt actttgattt ttttcaaaat ataatgctag gtaactggtc ttattaccca 3297001 gtcatcagat gatcatatca tctatagaaa ccgcttacat atggcgccag tttatgtttc 3297061 aaggaggggt ttgggatgca atggacacag gcatatacgc ctataggggg aaatttgcta 3297121 ttatcagcgc ttgccgcact tgtaccgatt attttctttt tttgggcact cgcgattaaa 3297181 cggatgaagg ggtatacagc aggcttggcc acattgggga tcgcccttat cattgctgta 3297241 ttggtttatc gtatgccggc ggaaaaagcg ctgatgtccg cgacacaagg agccgtatac 3297301 ggattgttgc cgatcggctg gatcattgtg acgtctgttt ttttgtataa aatcactgtg 3297361 aaaacgggac agtttgatat cattcgcagc tctgttctct cgattactga tgaccgacgg 3297421 cttcaagctc tcttgatcgc tttttcattc ggggcttttt tagaaggggc agcaggcttc 3297481 ggagcgccgg tcgccatttc tgccgcgctg ctggtcggtc tcggctttaa tcctctttat 3297541 gctgcgggga tctgtttgat cgccaatacg gcgccggttg cctttggggc aattgggatt 3297601 ccaattacag ccgtagaagg gccgacaggg attccggcga tggagatttc gcaaatggtt 3297661 gggcggcagc tgccgttttt atccgtattt attcctcttt atttaatcat catcatgagc 3297721 gggttcagga aagccttgga gatctggccg gcgattctcg tatccggtgt ttcctttgct 3297781 gttgttcaat atctcagttc caatttttta gggcctgagc tgcccgatgt tttgtcagct 3297841 cttgtttcaa tggctgcgct tgctgtgttt ttgaaatggt ggaagccgaa aacaacattc 3297901 cggtttgccg gtgaacaaga gtcggccgcc tcaattgaaa cggcgcgcac aaatccggcg 3297961 gcgcctgcat acagaggcgg acagattttt aaggcttggt cgccatttct gctgctgacg 3298021 gcgatgattt ccgtatgggg cattccatct gtcaaatccg cgctgaccgg gcattatgaa 3298081 ggctctgcgg tgttcttgaa gtggctgaat gctgttggag aaaaactgac tttttccccc 3298141 ggtgtgcctt ttttgaacaa tcagattgtc aatgctgacg gtacgccgat tgaagcggtt 3298201 tacaagttgg aggtgcttgg ttcggccggc accgcgatat tgattgccgc agtgctgtca 3298261 aaattcatca cggcgatttc gtggaaagac tggggaaccg tttttaaaga aacagtccag 3298321 gaattgaagc ttccgatttt gaccattgct tctgtcgttg gttttgccta tgtcaccaac 3298381 tcctcgggaa tgagcacgac actcgggatg acactcgcgc tgacaggttc gatgtttacc 3298441 ttcttttcgc ccgttctcgg ctggctcggc gtcttcatta ccggctcgga tacttctgcc 3298501 aacctgctgt tcggcaacct gcagaaagtc accgcattat cagtcggcat ggaccccgtt 3298561 ctgtctgtgg ccgccaactc ttcaggcggt gtcacaggaa aaatgatttc accgcagtcg 3298621 atagcggtgg cgtgcgccgc ggtaggactc gccggaaagg agtcagatct tttccgcttt 3298681 accattaaac acagtctgtt tttgctgctg ctcgtctgta tcatcacctt tttgcagcat 3298741 cacgtattca gctggatgat tccttaaaaa aatcctcccg tctagggagg attttattta 3298801 tatcgctttc tcgctgccga tgacggaata ttcatttgat cgcgatattt tgccacggtg 3298861 cgtctcgaga tttggatgcc gtgttgttca tacagcaaat cgacaagctt ttggtctgaa 3298921 agcggttttg ttttgtcctc ttgattgatc aggttttcca gatgcgtttt gactgcataa 3298981 ttcgacgcat ctccatcacc tgaagcctcg gcttttgctg agaaaaagag tttcatctca 3299041 aacagcccgt aaggcgtttg tattgttttc cctttaatgg cccggctcac agttgattca 3299101 tgaaggctta gacagtctgc cacctctctg agagtcagcg gcttcattgc gcttcgccct 3299161 ttcagaaaga aatccttttg gcgtgtgatc agttcattga taattctcgt gattgtctgt 3299221 tttcgctgcc gcagcgcgcg gctcagccag cgccactcct gatatttcgc agataaatag 3299281 gagacagtat cctgacagga gccggatgat aaaagcgttc tgtactgcgg atgcagatcg 3299341 atctcgggaa acgagcgggt attcagttcc gctgcgatgt gcccattttt tacggtgata 3299401 aaaatgtcag gctcaatata cacatcttgc tctggccggg caaacagaag gccaggtcta 3299461 ggatgaagag ccgcgatatc atctgagata tcttgaatgg tatgaagcgg aattcccgtc 3299521 tctactgaaa gcgttttcca ttttttttgc gcaaaagcat caaaatgagc tgaaaccagc 3299581 atttccgctt gttcatttct gttcggcagc cgctgtaatt gaagaaggat gcattcctgc 3299641 aaagatctcg cgccgattcc agccggttct aacgactgga gttttgccaa aacagcctcc 3299701 gcttccttgg ccgatacaga taatcgccgt gctgcctcct ctatatcttc ttccaagtac 3299761 ccgtttgaat caagcgaatg aatcagataa ttaaaaatct ttttttcagt gtttgtcaga 3299821 ttcatatcga gtgactgctg ttttaacgca tcctgcaatg ttttttgcgg attacttaat 3299881 tgaaggcccg cttcctgtgc attcatcctg tttttgtttg ttttatggta agatagtggc 3299941 ggtgtgtctg tttcctttcg ttcaataaga gggttttcca gtgagagctc atcaatgtac 3300001 tcggcgagtt ctgccgaatg atagccaagc agcgtgatgg cctgcctgag ctcctgtgtc 3300061 agttgaggct ttaatacttg tacttgctga agtttcatat ccatcttgct cactcccctt 3300121 tcttcattgt acatgattga gatcacaccg tatacattta tgaaaaagga gctgccaaag 3300181 aaatgtctga acttttttcc gtcccttatt ttattgagaa tttaaaacag catattgaaa 3300241 tgaatcagtc tgaggataaa atccacgcga tgaacagcta ctaccgttcc gtcgtctcaa 3300301 cactagtgca ggaccagctg acgaaaaacg cagttgtcct gaaacggatt cagcatttag 3300361 atgaagcata caacaaagtc aaacgtggag aatcaaaata aaccttccgc tcacatgtga 3300421 gcaggaaggt tttccttctt tgaggcgtgc tggatgagac gggtgcttgg cacgccttcc 3300481 atccaggtat gaaagtaatt ggcgtttttc ccgtaggaat tatcaatgac cgtgttttct 3300541 ttttgaagaa gagaagacag gatgtggccg tgcagccttg atgtttccac cgattcgtaa 3300601 cggctgaaaa accgaatcgc tttttggacg atataatccg agtatttttc ccatatatac 3300661 gcaatgggca aagggttgcc tgctttttta ttcaagacgt tcagcgtttg gagaaaagca 3300721 atcgtccggc ggtctgaagc tgacagcacc gtgcgccagt cgtagctttc cgcttctgcg 3300781 tgttcctgaa gcgcctggtt tgcttcatga tctgttcgga taaatctcag cttttgattg 3300841 gacggctgct gcgtgggaat gacgggaaac agctgatgag ccatatcagg cagaagctga 3300901 atgtgatttg ttgtaaaata ggcctgtgcc gtagcatagg aggctttttc ccttgtcatg 3300961 atgtgaaggt tcgcatgctt agaaaatatc tctgccgtcc gcttgaggtt gtctttgttt 3301021 tgaaaataaa tcgattgcgg caggatcaca attttgtggt tcggataggt ttggacgatt 3301081 ttctctctaa agccttgata atacggatac agatccccga agtttccgcc tccctggcag 3301141 acgatgatga gattcggatc aagctttcgc ccgattggga aattgtctgg attccagcgt 3301201 tttctgaccc gaatcccgtg ttctttaaag aaggcttctg ttcctttcat aataaataaa 3301261 tcccctacat tcccatatag aggatagtca gcatatataa tctctgattg tttcggaatg 3301321 acgtcgagca gcccggacag tttctgtttc aggctgatca tcgaatgctt gctgtccatt 3301381 tcttcacctc gacagtatgg aataagtgca gtagcacttc aatgacccgg ccttgctcat 3301441 cttctgtcat attggacccc gatgggagac agattcctcg cttgaacaaa tcttcgcata 3301501 cgcttcctgt atcttcatga gaataaaata aagccggatc gaacagcggc tgggtatgga 3301561 gcggcttcca cagcggacgg gcttcaatgt tttcttcagc aagacgttga actatgtcat 3301621 atgggctgag cccgttatca agtgtgagcg tggtgagcca gcgattggat acgcctgctg 3301681 cgtactctgg cataaagcgg acgccgtcta agtgaccgag cgcatttttg tatctcgtga 3301741 aaatggtcct tcttttctcc actcgctcat ccagcacctc aagctgggca atgccgacgc 3301801 cggctaagat attgctcagc ctgtaattat gtccaatttc actgtgctga taatgaacag 3301861 ccggctctcg tgcctgcgaa gcgagaaatc ttgctttttc aattgcggct tcatcatttg 3301921 aaacgagcat ccctccccct gatgtggtga tgattttgtt cccgttaaat gaaaaaatgc 3301981 cgaagcgccc gaatgttccg ctttgcttcc ctttatagac tgtgccgaga gattcggctg 3302041 cgtcctcaat gacaggaact ccgtatgcat cacacaggct tacgatttca tccattttcg 3302101 cgctctgccc atatagattg acggcaatta ccgcttttgg cagtgttccg tttcttttcg 3302161 cttcctccaa tgctctttca agggctgtcg gcgacatatt ccacgtatca ggctcagaat 3302221 caataaagac gggcaccgct ttttcatata gaatcggatt ggcggttgct acaaatgtga 3302281 aggactggca aaacacgctg tcaccttctt ttacctcaag caaacgcagc gcgagatgaa 3302341 tcgccgccgt tcctgagccg accgcagctg ctgcttttac accgactcgt tctgccagct 3302401 gttcttcaaa tgaattcacg agcggcccaa gcggcgcaat ccagtttgag cgaaaggctt 3302461 ctgaaatata gtgctgctcc ctgccgctca tatgaggggg agataagtag atttttttat 3302521 gcatagaatc atcctttgtt tgatgtttga atggaagaaa tgatgcgtgc cggagcaccg 3302581 gccgccgtta ccctgtccgg tatggaacgg atcaccgcgg agccggctcc gacaatgctc 3302641 caagccccga ttatgatctg cggtatgacg gatgcaccgg ttccgacgtg agcgccttcc 3302701 tgaacggaaa ccgctcctga cagcgtggca cgcggggaca gatgaacgta atcgctgatt 3302761 tgattgtcgt gctctgccac tgcacccgta ttgatgatgc agtgggcgcc gatgcgcgca 3302821 tccgcctgaa tgatcgcgcc cgccataatc actgtccctt ccccaatgac agccgacttg 3302881 ctgacgatgg ctgacgggtg aatcaatgta ataaaatcat ctttccccag tcccagtcgc 3302941 tccgccagct gttttctgac actgttattc ccaacagcaa tcagaaacag cacatcagga 3303001 atgagcctgc gcagttcagt aacggctttc ggcggtcctg tgtaccattc ttttccgcct 3303061 tcgaacgttt tgaatttatc atccagcacc gcggctaagc gcgtatctga gcgggcgttt 3303121 atcagctctc tgatcacctt tccgtgaccg ccgtcaccca caatggccac atttttcatg 3303181 aggacacatc tccgcttccg gtaaaccgtt ccgcggtcac atgattggtt tgctgaatcc 3303241 cttctgaaac aaggaccttt cgcaccgtca aacataaaat tttcaaatcg agaaaaaatg 3303301 accagttgtc aacgtaccaa acatctaatt caaatttctt ttcccaggaa atcgcgtttc 3303361 tgccattgat ttgcgcccag cctgtgatac ccggcttcac ctcatggcgc cgtgcctgtt 3303421 tttctgtata aagaggcaga tagtccatca aaagcggccg cggcccgaca aggctcagat 3303481 cgcccttcag gacattcagg agctgcggaa gctcatcaat gctcagcttt ctgatcagcc 3303541 tgcccgtttt cgtcagccgg acttcatcag gcagcagatt tcctttactg tcccgttcat 3303601 ccgtcattgt ccggaactta tatagggtga acggtttgcc gtgcaggccc ggccttactt 3303661 gcttaaagaa gacaggtgat cctattttca gcctgacaac ggcgatggtg aacagaatga 3303721 tcacacttgt acagcacaac aaaaaaatgg cggccgtcag atcaaaaagt cgtttcagga 3303781 tcaaagattc acagctcctt tcgtttttcg aaaccgtttt aataccagct gtctttcctc 3303841 ttttgtacaa acgagcataa aagcgaaaac agcgtagcaa aagctgactg tcactcccgt 3303901 cgctatcaat gacggccagc tgtcaatctt cacaatgaac tgaattgcct tacagaccgt 3303961 ccaggcaaat acagcggctg aaagaggccc gattatgcct ttaaggaaca cgtgcttttt 3304021 gtagcctgta atgcgggata cgtaaagcgg cgtaaagatg gcatttttta aaataagaga 3304081 aatggcccct gccaatgtta tgccgtacag accgagatga gccggcccgc tcagcgtgac 3304141 cgccagcacc acattcaccg cacctaacag cagggtaaca atcgccggtg ttttttgttg 3304201 attaaaagcg gtccatatat aaaacagcgg cataaaggcg aggctgacaa ccaagtatcc 3304261 ggcatgaata aataaaagcg gtgctatcgt tgaaaaggac ggtccgagcc agattgtcag 3304321 aaaaggtccc gccaatccgc ccaataaggc agcaggaagt gcaagcaaaa gaccattgag 3304381 ccttactgcc ttattggcgt aattcatcaa tccttccata tcgccttttg aataatatga 3304441 agtcatgatg ggcgcaaaca gggatgcgac cgttccggcc aagctgcgca aaagcagcgg 3304501 aaactggata atcgccgcgt atttcccgga tgcagacgcc cccagcatca aattggcggt 3304561 taacagatca atctgcaaaa aaagcaggac gccgatttga ttgacggagc tccatgcgcc 3304621 cgcttgaaac agctccttgc ttgtacggaa tgaaagatcc ttcatacgaa acgaaaacca 3304681 cggaatcagc tttttgaaga aatagaaaga cagcacagac gcaataacag caccagctaa 3304741 agctgcaagc tggatctgcc agattttcgg cgcaaagcat gcaaacagga gcagcacaga 3304801 cagcacccgt ataagcattt gcaccgcctg aatggaactg gtgatataaa ggcggttggc 3304861 ataaaatggt gcagcgccga agcccgccat cagaaacgtt aaaataaaca gcacactgcc 3304921 gattaaaatc gacaaacgca catctgccaa aagcgcttgc ggcacattca tgacgcggtc 3304981 aataaaaaaa gccgaacccg caagcggcag caagagcagc aaggaaatca aaacagaggc 3305041 ggctaaataa ttgctgatat acgcatttgc tttctcccgc tctcccctgt gggcagcaac 3305101 agaaaagaac cgaacgacaa ccgagctgag cgccacggta ataaccgaaa agtaattaat 3305161 cacattttgt gtcaagtgaa caaagccaaa cgcttcgaca ccgagcgttt tgacaataaa 3305221 aggcgtcatc caaaccgata ggaaaacaga caagagaaaa gccgtgagat tcgcgctgaa 3305281 atttatcgtg aatttcatgc ctgcttcgca ctgcctttca ttgtcccccg ctgctcgaaa 3305341 aacagcttga tgagaaaagt gagccgccat ttacacagtg ctaataccaa acgctctcct 3305401 cttaataatt tctcatgctg aaacggtgta tgtctgacag cctgccgcac catgtcatag 3305461 gataaaatct gtctgatctt ctttttgatg tctttcggcg aattcggaga agcacaggca 3305521 tttgccaaaa gcatcggaag ctggtgcctg caaatgtaca cattcaaatc ttctttacat 3305581 gcgcctgcta agccgtagtg attgtagaat gcgattttag cctgatattg tttttgaaga 3305641 tgttcatcca tcgccggctt ataagggatt tctgtcaggc tgttcgggtt ttcacgataa 3305701 atgtacaatc cttcatcaag cattttcacc cgctccgctt cgcgaaaagc ggacaaatta 3305761 aagggagagt cttcagcaaa acggatgtct tcatcaaaca gcagattcgc cctttcaaaa 3305821 agctcacgac ggtaaagata acgccataca taccagataa atctcgtttc gtgagcatgt 3305881 ttaagctgtt cagtcatttc tggtttcgtc agcacgcggt ttgcctcaag ctgcggcggc 3305941 acatatgtcc gcctgtccga tgactgcttg taaaaaccgc atccgacgat gtcaagctga 3306001 ttttgctccg cttcttcagt cagcctctgg aacatggcgg atgatacata atcgtctccg 3306061 tctacaaagc cgatgtaagt gccccgcgcg gcctttattc ccgtatttcg cgctgaacta 3306121 agcccgccgt ttgcctgatg aatgacccgg attctcgcat cccgttttgc atagtcctct 3306181 gcaatttcgc ctgaacgatc cggtgttccg tcattcacga ggatgatttc aatatcagaa 3306241 agcgtttgac gaagcaaaga atcaatgcac tcttctataa atggttcaac attatacatc 3306301 gggacaataa tgctgacgag cgggatcatt gcgcttcacc gctgattttg tcacgcagac 3306361 ctttaaaata cacatctctc ggaaagcctg cacgggatgt ttcttttgtt aaaagctcat 3306421 tgactgcggc tgttacgcgc tctggctccg gatgttctat cagcttcatg aacgggatgt 3306481 ctttaagcca ttgatagccc tccatcacct tatggtcaaa ggagcgaatg acaacacacg 3306541 gcgttcctgt cagcgcgcaa aaaatcatgc catgaagcct gtcagtgacg acggcttctg 3306601 cgctttgcag cttagaccac agtgcttcaa gttcatgttc gcgtgtatcg cggctgaccc 3306661 ggcggccgat cgttgtcgta aaggatttga tctcgccgaa ttcctcacat agcgcagcct 3306721 tgacccggtt cctctgctcc tcctgaagca cgctttcctg atcctcgcgc aaacacatat 3306781 aaaccccttc gcgttctgcg ggagccttgc ttctgtctaa atacagcacc atgtccggct 3306841 gcttcaaaat tgttttttct tgaaaatgct gtttcataaa ttgatacgtt gtttcatccc 3306901 gcgccatcag caataggccg gggtgcgcat tataaatttt ctgtgcccgt ttcagctctt 3306961 tgcgcccttt tttcgtgtca gaaaaatgag ccgttgccgg aagctggaca acccgatagt 3307021 catggaatgt tttaatgatg aagcggcgcg tccactcctc ataacggtat aaatccccca 3307081 tgtttccgcc gccgatgata aagaccatat cctccggatg gcgcgagcgg atcaggcttt 3307141 ttgctgattt gtaaatgtcc ttcatatcga cctcgacgat gtcaaagtcc gggtattctt 3307201 gctcaagaaa tgccttgctg gcataagcaa ttgcgtgatc tcccaaattg tcatgggacg 3307261 gcagcagggt cagtatgatt tttttctgat gtgctgcggc ctttaccggt tgatctgccg 3307321 ctcccagcca atattgggac gggtatttga cctttagcag cagccattct gcaaaattga 3307381 ttttcaacga ttgtaacgac atgtcctcac cctctgtttc tcattttgta ctcgatcacc 3307441 cgctgataca cagccgatgc catagcgacg aacggaatca ttctgtattt cgccatcaga 3307501 agcaggcatg accgttttgc gtcaaaagga gcagtacccg tttttgaaag actttcttga 3307561 aacaccgggt ccgcgcatat cacgccaaca tttctaagct tttcaaacag ccggcggctg 3307621 ccgctcgttt tccattcatt cagcatacag atgctgctgt gaagaacgat aaaggtatca 3307681 agctccttgc gatactcctc cagtttgttg ttctcctgta aaaacgccgc attcgtctca 3307741 tacagcgcaa gtcctgattc aaacaatttt ttctgatagc gctgcacaat ggaggaaagg 3307801 tgaattcgat aatgatagag cggcgttttt acgtaggata ctgagcgggc gaaaaaatga 3307861 gccctgaagc tgaaaaactg atcctcgaca tgctccagct cgcctcggag cggaaacgac 3307921 agccgatggg cttcaatcat gcttcttctg tacagtttgt tccatgaaaa ccctctgacc 3307981 ttcccttcga ataacgcctt gatatagtgc tccttcggct gatcctgata ggtttgggca 3308041 atgtcagagt ccatggtttt gccagtgtcc tcaaactctg cggcgtaatt gcaaatgacc 3308101 agatcagttt catcgcctgc tgtccggagc atctgctcgc aataatcagg ctcaatccaa 3308161 tcgtctgaat cgataaacgc gataaattcg ccgcgtgcag cttcaatgcc tttattccga 3308221 accgcaccga gtccctggtt ttcctgatga atcaccttga acctgttgtc cattttggcg 3308281 tattcttctg cgatatccgg gctggcgtca gctgaaccgt cattgacaat gatgatttca 3308341 atattgtcca ttgtctggtt ccgcagtgat tcgagacacg ttctgatata tgtttctgtg 3308401 ttataaacag cgactaacag actaaccgca ggtgtttcca taatgaccgg ctcctcgtgc 3308461 ataaattacc gggaaaaaat cgttctgtaa ggcagaaccg atgaatcgac cggcataagc 3308521 aaataactgt aaagaaaata acaaacaacg atagcgatat agataagagc gttcgatttt 3308581 tcatcaaata tcctgacgaa ataagggact aggatcattt gatacagacc gaaataaata 3308641 ttgaatctgg caaaaatcac gtcctttgtg gccaaaaggc cgaacaaaaa acctagcagg 3308701 cacaaattga cgacaatatc aatttgcggc cacagactcc gcagtcgttc tttatagcaa 3308761 aatgcaagga acagcggcag aaccaaaaca gcgattttga tcacattcat tccatttgtg 3308821 ttcgtcatga gccatttttc ataatggctg tatgagctgt tttcaagtac aacgacaaac 3308881 acagaaataa atttttgata taaaaatgtc atgccgagaa ataaagcgga taggccgaat 3308941 atcgccggtg accaggcttt tcttctgaca ataaagtaca ctggaatcat aatcagcgcc 3309001 gacgaatgaa agagcgagct gaccagcaca atcaggaaat atcgcttcca gttcccgcta 3309061 atgatataac ggatcgccca aaacaaaaca gctgccacca tgtattgcct gatgccgtta 3309121 aaagatgcgt aataatgaaa ggttcccaaa aataaaaaga cactcagctc aaacggcctg 3309181 ccatagtcgg cgagtgtctt cataataaag ctgtaggtca cgaccgccac cgtaaaatac 3309241 atgatttgag gatcttccgt gatgaaattc atcagccaaa ggagtgcggt aaaccccgga 3309301 tctgtcgctg ttttcgctgt gccgaaaccg aatatctgcc acacattttg ataatcgccc 3309361 gccaattcgt acaacagcgt gtacgtctga aaatccgtgc cgactcgata gcggagacct 3309421 gacacgagca caagtgaagc gagcggaatc cagatcaaaa gcttattcgg ccgatacccc 3309481 gtggcaagcg aatcatcacg gccgccgcac attttagcga accaagacca aataaataca 3309541 atccccatat tgacggcata tacaatcatc ggttatggtc cttttccgtg ctgatgttgt 3309601 atacattcag cagcgctcct acattttgct gtgcatcgta gccaagttga gcgagtgttt 3309661 ctttgatgaa ctcacgcttc ggcctgcctg cggcggccgc ccttgcaatg gtttcagccc 3309721 agacgctgat cggctcagaa agacttaatc ttgtgacaag cccgagaccg gcgtcgactt 3309781 tttctgtaat gctgtctgaa atgatgcatg gaagccccga cgcctgcgct tccacaagca 3309841 caaccggcaa gccttcgtac agagacggca tgacaaatac atcgaatgtt cgcatcagtt 3309901 catggatccg ttcttccgtg cctaaaaaga ggacgtctga tagcaaattc tgctgccgcg 3309961 cctcctcctc tatctccccg cacaacggcc cgtctcccgc cagaacgagc tgaaagcgaa 3310021 tgcctctttc cttgagatgt gcggcaagct tcaacaggaa cgcgtggttt ttcacttcat 3310081 gaaaccgggc cacatggcca atgatgagcc ggtcggctgc aatgccgcgt gctgcttttt 3310141 cttcatcagc cgcctgccca tttggggcga acaactcaag gtcaatcccg ttaggaagaa 3310201 ggtgaacacg ctcccgctcc atattggact gtccaaataa aaacctgccc gcatcctctc 3310261 cgcaggcaca cagcgctgtc gcatttgcca aaatgagccg cctgaacacg agcagctgca 3310321 atcgatcctt ccagttgaag ccggtcttcc aagacgtatt gtgggagtgg cataccctga 3310381 ccggcactcc ggcgagcctt gccgcaaggg cgataaaacc cgtttggaaa tccgtgtgcg 3310441 catgaacggc gctgaacggc ccattttctt ttatcgcgtt tctcacattc ctcacaaatg 3310501 taaggggatt gctttgccca atgctcggga cataaaaaag ccgcccgcct aaagataaaa 3310561 tctcttcatc ataagcgcac ggatcatttc gatacgttaa aaaatcaaat tgcactttgc 3310621 ttttgtccat cttccgatat aaattcatta ccatggtttc cgcgccgccc ctgttcatgc 3310681 cgctgagaac atggagcacg cgcttttggc tgctattcat gcttgacaag cccttccttt 3310741 tggttcatca ctcttttttt atggtagcga ttcatcacag ctgcaggcat aaaggcgcga 3310801 attaacggtt ttgcgatata tatgtaatca gataaaggaa gcttcaagcg tctgcacgcc 3310861 tgatagacaa gaatggcatt gtcgattgaa tacgtaaatg accgccgttt gaatgcatcg 3310921 ctgtcttccc tcactttata caaggcttcc tgaagattat agcccctgaa gccctcttca 3310981 aaaaagcgaa gccacaaatc aatatcttcc attcgtctcg tccgccgcac cgaccggtag 3311041 cctttcagcg tgcggtaggc actcgctctc atcataatcg tgccgtggca aaatggagtc 3311101 ccttttgcca tgatgcccgg ctccggaaca gaaggcagaa tgcgggcgcc tcttacgcca 3311161 aattcatcaa acacaagcat gccggtgcca accacctgat agtgtcggtg cttttctaaa 3311221 aacgcgacct gcttttccag acggcgcgga aacgaaaggt catctccgtc ctgacgtgcg 3311281 atataatcgc ctgtcgcatg cgaaagacaa tgatttaatg atgcggcaag ccgcttattt 3311341 gttttgtttt gaatcagttt gatgcggtcg ctgtaatgag cggcatactg cttcgcgata 3311401 cggagcgtgc cgtctgttga cgcatcatcg cacaaaatca gctcccaatt tttataggat 3311461 tggctgagta tggattctat gctttctgcc aaagtgcgtt cgcaattata aatgcccata 3311521 atgacagaaa ctttcggtcc tgagttcata cgcttttctc ctttgtatcc atatccatgt 3311581 acgcggaata aatatctgcc atttcttcca ccgttcgcgc ctccgagaag cgcaaggctg 3311641 tttttcggcc ttcctgtccc agctttcggc agagctccgg cttatggtaa agctgttcaa 3311701 tccggcgggc aaaagcagca ctgtcaccga ttttgatcag aaaaccgttt tctccgtcgc 3311761 ggatgatttc ccgatgcccg cgattatctg tggcgatcgc cggttgttct gccgccattc 3311821 cctcaagcac attcataccg aggccttctc taatgctgga tgcgacagat acatccgcaa 3311881 gctgaatcaa ctcatgtatg tcgctgcaaa agccgtaaaa acagacatgg gcggaggcac 3311941 caagcttttc agctaacgtt tgatacgtat gttccattgc cccttccccg gcaaacacaa 3312001 ggcggagtga gggaattttt tcttttagca aggctgcggc ttcaattaac tgcttctggt 3312061 ttttgttcag attgagctca gccggataaa ccaatataaa atcatcttca cggaacccgt 3312121 gcttttctct gagtctttgc tgctctatcg gactgacagg ccggaaacgc tcggtattga 3312181 cgccaatgcc gtgaattttc tgcgtccttc cgcccggcct ttgaagtcct ttcgcccgta 3312241 tgtaatcctc ttcattaatc gtaatcaggc agtctgtata tgctgaaagc catttctcaa 3312301 ccggatagta aagaagccaa tttttcatcg gtgccccttt gcagaagtga aatccgtgcg 3312361 ctgtgtacag cacctttgtt ccgtgccgcc gtgcctgcct cgccgccagt ctggcgagaa 3312421 cgccgccgac cggtgtatgg caatggacaa tgtcgtattc ataagtgtca atcactttct 3312481 tcagctgcct ataaacggcc aggttctgag ggtcaaaagg tgacctgcga atcgggatgg 3312541 agaatttctc atccacatac ggcagcttgg tttgtccgtt cgcggcgaca tgaacctccc 3312601 agcccatttg cttgaaccat ttaaaataag ggaggtgaaa ggccttaaaa tgataatcaa 3312661 cagtcgcgca aaacaatatc tttttcgtca ttttcactcc ccctaatgaa cgctggcagc 3312721 cgtcatttct tctgatgtat tgattgccgc aaacagcctc gctctcaggt cggcttccgg 3312781 cagctcatga aaatcctcga taaagcgcat cagcaccggc caatcgccgt ccaccgcttt 3312841 accgatgtga atttttggaa agatttgttc agcatggact tcatttttgt tcagcaattc 3312901 ttcatacatt ttttcgcccg gacgaatgcc tgtgaattcg attggaacct gctcagtcgt 3312961 gtagccggac aaatgaatga ggtttttggc aagatccaca atctttacgg gctctcccat 3313021 atcgagaacg aaaatttgac gccctttcgc cagtgcccca gcctgaatca caagccttga 3313081 tgcctcggga atcgtcatga aatagcgggt cattgccgga tgtgttactg tcaccgggcc 3313141 gcctttttca atctgttttt tgaaaattgg aatgacgctg ccgcggctcc cgagtacatt 3313201 gccgaagcga acagcaacaa atttggttct gctgactttc ccaagattca taataatcat 3313261 ctctgcgaat cgttttgtcg cccccattac gttggctggg ttcaccgctt tgtccgatga 3313321 aatcagcacg aatgtctcag ttcccgacat atcggctgct tccgcgacat tttttgttcc 3313381 gataatattg tttttgaccg cctcttctgg attgtgttcc attaaaggca catgcttatg 3313441 ggcagctgca tgatagacaa catgcggctc gtattttttc atcaaggtaa acattttatc 3313501 gcggtcctgc acatcagcga tttccgtatg gaacacaatg tgtttgccga atcgtccgtt 3313561 cagctctgta taaatcgaat gaatgctgtt ttccccatgg ccgagcagaa tgatttcctt 3313621 aggctgaaac gcgctgatct gacggcagat ttccgagccg attgatccgc ccgctcccgt 3313681 gacgagaact gtttttcctt tgatgcggtt cgaaatttcg ctagtgtcga gggttaccgg 3313741 ctttctgccg agcaagtcct cagcttttac atctctgatt tgtccggcag ttcgtgtgcc 3313801 aagcagcatt tcatcaaaat gaggcataat tttaatgctt actccggttc gcacacattc 3313861 tttatataac acctgaagct catgggtgcg gagtgaagga atggcaataa taatataatt 3313921 aattttgagc ttttgcaccg caggcatgat actttctttt ccgccgatta cgggcagccc 3313981 cataatttct aatttatgct tcgtttggtc gtcatcaata aaagcgacag gtatgatatc 3314041 aggttcatct ttcgaaagca gctgcctgac catcagagtc ccacctgagc ccgccccgat 3314101 aatcagcgcg cgggacgagg cgcagcgttt tttcctgatg ctttcgttta atactctgga 3314161 taaaatacgg gtccctccaa tagacaaaag ctgaagcacc cagcacgcgg ttaacagacg 3314221 gaagaacatc gtgtgataca cagcatactg aatgacgccg gtcacagcgg ctgaaagcgt 3314281 aatgccctta agcaggacaa tcagctcgcc aagcccggtg tatgtccaca cctgtttata 3314341 ctgattgaac aggaaagcac acacatgata gctgaggagc aagctgacag cggtaagcag 3314401 taatgctccg gagtcataaa attgatagga atcttttaaa aattgatatc ctgcaataac 3314461 tgaatttaaa acgaggtaag tatccagcgc aataatcatt gacagtcttc tccggtaact 3314521 caaccttttc ccccctaatt cttttatcgg tttagctgcg gcggttttcg tctctccaaa 3314581 aaatcggcag cagctaaacc gacaatacgt cctatgtata tatgagataa gtgggcattt 3314641 aacccatcct cacgccccgc cagcgacgac cagcatctaa ggcagcaact tcagctgccc 3314701 acagcagagc cgagtgcctc cattgataca ggtcaggaga catcaccttt acaaaaacta 3314761 gtaggaatag tgttccgatt ttttcatttt ctttttgttt aaaagagcgc ctaacagctt 3314821 cgcattggat tgttccagtg catcttttgc tttcagaacg gtatcggttt ttgtttttcc 3314881 gcttaaaacg acgagcacgc tgccgtctgt ctgatttgct agaatctgag catctgcaac 3314941 agccaaaaga ggaggggaat caaagatgac gaggctgaat tgttcataga tctcagatat 3315001 taaatctccc attgcttttg aagacaacag ttctgccggg tttggcgggg tcggcccgct 3315061 tgtcagtaca tataagttat cgatcggcgt cttttgcacc gtctcactga gtgaagcatt 3315121 gccgaccagc acatttgtca gcccggttac attatcaacc tgaaacgtct gattgatggt 3315181 cggctttctt aaatcggcat ccaccagcag tactttcttt tcctgctgct gcgcaaagac 3315241 agccgcaaga ttcgctgcac tgaacgattt accttcacca ggcacagagg aggtgacgag 3315301 gatagatcgc aagttggtct ggacagatga gaactcaatg tttgtccgaa tggtgcgata 3315361 ttgttccgca acaactgatt tattgtgtaa aacagatatt tgagccaaac ctcgccttgc 3315421 tttctttttt ctaaagatca ctcgcttcac tccccgaaat gttttatccc gcgattccgc 3315481 cctttgtgga catcaggaac ggagcctaag catggcaatc cggttctctc gctgagctgc 3315541 cgtgcgcttt tgcatgtatc atcgagaaaa tgcagaaaaa atgccagtgt aatgccgccc 3315601 atgacagcag cgccaaaagc catgaccata tttcgcagcc tggccggctt gatcatcggg 3315661 ctttccgaag ccttcgcctc tgataatata tgtacgcctt gtacattcat tctttcatct 3315721 acttcttttt caaacttgtt cactaacgtg ttcgcaatct cagctgcttt cgccggatcg 3315781 tgatcctgaa cggcaacgtt gattatttct gattcatttt cactgctggt aaccactttt 3315841 cctttcagcg aggaagccga ttcagatagg tgcaattccg ccttaacttc ttccatcaag 3315901 gcagtgcttt tcataatcga ttggaacgtg ctgctatact gaagatttcg ctggatgtca 3315961 ctgagattcg agttttcttc accgtctgat tcatgaacca gcacctgtgt cgacgcctgg 3316021 taggtcggtg aaatgacctt aaattgcaca aaacccataa taagggtgac gccgattgtg 3316081 atgagcagaa tcagcacgaa tctgtgtctg acaatcgcat ataattcttt gaaactcata 3316141 ttctcattca tgtattcata gccttcagcc ttcccgcggc tggcttcccg cgcccctttc 3316201 tgttaatgat tggattataa aagaaaacgt tattatttaa aaattgcaaa ataagccaat 3316261 aagttctctt tagagaacaa aatcatgatt ttcctctaat ttactgcact tcccttatta 3316321 ttttaaattt tataaagaac gaaaaattcc ttataatgaa cgaaataacg acaggaatag 3316381 aggagaattt catattatga ttggaagaat tatccgtttg taccgtaaaa gaaaaggcta 3316441 ttctattaat cagctggctg ttgagtcagg cgtatccaaa tcctatttaa gcaagattga 3316501 aagaggcgtt cacacgaatc cgtccgttca atttttaaaa aaagtttctg ccacactgga 3316561 agttgaatta acagaattat ttgacgcaga aacaatgatg tatgaaaaaa tcagcggcgg 3316621 tgaagaagaa tggcgcgtac atttagtgca agccgtacaa gccgggatgg aaaaggaaga 3316681 attgttcact tttacgaaca gactcaagaa agaacagcct gaaactgcct cttaccgcaa 3316741 ccgcaaactg acggaatcca atatagaaga atggaaagcg ctgatggcgg aggcaagaga 3316801 aatcggcttg tctgtccatg aagtcaaatc ctttttaaaa acaaagggaa gatgatgatc 3316861 ggttaaaggg ctaacgttcg catctatagg ggaaatctgt ttataatggg ggaaaaaggg 3316921 agagaacaca atgactcatc aaatagtaac gactcaatac ggcaaagtaa aaggcacaac 3316981 ggaaaacggc gtacataagt ggaaaggcat cccctatgcc aagccgcctg tcggacaatg 3317041 gcgttttaaa gcacctgagc cgcctgaagt gtgggaagat gtgcttgatg ccacagcgta 3317101 cggctctatt tgcccgcagc cgtctgattt gctgtcactt tcgtatactg agctgccccg 3317161 ccagtccgag gattgcttgt atgtcaatgt atttgcgcct gacaccccaa gtaaaaatct 3317221 tcctgtcatg gtgtggattc acggaggcgc tttttatcta ggagcgggca gtgagccatt 3317281 gtatgacgga tcaaaacttg cggcacaggg agaagtcatt gtcgttacat tgaactatcg 3317341 gctggggccg tttggctttt tgcacttgtc ttcatttaat gaggcgtatt ctgataacct 3317401 tgggctttta gaccaagccg ccgcgctgaa atgggtgcga gagaatattt cagcgtttgg 3317461 cggtgatccc gataacgtaa cagtatttgg agaatccgcc ggcgggatga gcattgccgc 3317521 gctgcttgct atgcctgcgg caaaaggcct gttccagaaa gcaatcatgg aaagcggcgc 3317581 ttctcgaacg atgacgaaag aacaagcggc gagcacctcg gcagcctttt tacaggtcct 3317641 tgggattaac gagggccaac tggataaatt gcatacggtt tctgcggaag atttgctaaa 3317701 agcggctgat cagcttcgga ttgcagaaaa agaaaatatc tttcagctgt tcttccagcc 3317761 cgcccttgat ccgaaaacgc tgcctgaaga accagaaaaa gcgatcgcag aaggggctgc 3317821 ttccggtatt ccgctattaa ttggaacaac ccgtgatgaa ggatatttat ttttcacccc 3317881 ggattcagac gttcattctc aggaaacgct tgatgcagcg ctcgagtatt tactagggaa 3317941 gccgctggca gagaaagttg ccgatttgta tccgcgttct ctggaaagcc aaattcatat 3318001 gatgactgat ttattatttt ggcgccctgc cgtcgcctat gcatccgcac agtctcatta 3318061 cgcccctgtc tggatgtaca ggttcgattg gcacccgaag aagccgccgt acaataaagc 3318121 gtttcacgca ttagagcttc cttttgtctt tggaaatctg gacggattgg aacgaatggc 3318181 aaaagcggag attacggatg aggtgaaaca gctttctcac acgatacaat cagcgtggat 3318241 cacgttcgcc aaaacaggaa acccaagcac cgaagctgtg aattggcctg cgtatcatga 3318301 agaaacgaga gagacgctga ttttagactc agagattacg atcgaaaacg atcccgaatc 3318361 tgaaaaaagg cagaagctat tcccttcaaa aggagaataa atatggggaa aacaggatac 3318421 attggtgctg ccattgttgt ggcagcttgt atcattattt tgtcggccgt ggtatgttta 3318481 cgggacacag tctattacca gcctatgcgc tggactggca tcatactgtt tttcgcggga 3318541 attgtgatgg ttcccgcata ctcagcaaaa agaaaacccg gaaaagagaa gtaattctct 3318601 tttccgggtt tttatgttta ttataatctt cccgcgcgaa tatcgtctgt cattccctca 3318661 taaggagcct tcgaaatcac ttcttcgttg tcgactcctt catttttcag aaatgtaatt 3318721 tccgcaaatt caggtacaac gtattttgga tacgtttcat atttttcgcg ggattctttc 3318781 atcaaatcaa tgtggtcatt ttggtagcaa accgtaattt caggatgttc atgcacccat 3318841 ttcgggaaga aaataatgcc atgcatgcgt ttttcatttg gcataaagtt taatgaaaca 3318901 tccgtgccag tcggctctgt ccaagacact ttatatacgc cttctgtcag tttgacaata 3318961 ttcacttcct gatctcgaac ccagcgtccg gcaaccattc cgctatgaat tctataatca 3319021 attgtatggt cgtttttaat ataaatctcg tattcccatc cgttttcata cgtataaatc 3319081 atgtggcttc cgataaagtt ttccatctta cacactctcc ttagtctttt actgtacttc 3319141 ataaatgtct agtagaacgt aatcaggggt tctttctgcg gaaccgataa acaagcggtc 3319201 atggagccat tgatagactt cactgcctgt ttcaaacgtc ggtaccgtac gaaaataaac 3319261 atgctccggt tcaataattt ccccggctgc cgcttgtttt cgaaacggct tgctgacttg 3319321 ccgtattcca ttgttttcaa tgtaaatcag ttcatgatct gctgtttcaa tcacatacct 3319381 ggcagataaa tctgttctgc cgttagcgcg aatcatttgt gaatcggcac cgcccggcaa 3319441 aatacgtccc tttacttccc cggttattgt tcccgaacga atcggaatga atcatctcag 3319501 tcccaggctt gtctcaccaa tcgtgatagg cggatcaacc ttgatttcta aagaggcgaa 3319561 tggttttaaa accggcttct tcacgagaac cacctcacct tcagaaaaaa tcatgtaact 3319621 atttacatgt tcactttaac accattgcag ttaactgtca aacaatagga acataaaaaa 3319681 acaaggactg tttgaagaca gtccttgtct gaagctagct ttgataagca agatatgtgc 3319741 tgacagtgct tttggcaaga caggcagagg aatctataat cggaatctca ctttgaatat 3319801 gatctaacac cgcatttaaa tccgtgcagg ctgaaatgat gatgtctgca tgctgactga 3319861 tttcttcata tagcgtctgc cacaatgctt gtgtatgctg catatgattt ggctgtttga 3319921 ttgcggcgat aagctggttc acagcctgct gccaatggtc cttgtgaata acttcttgtc 3319981 catttccctt cagaactttt tggtagatgg cggattggat ggttggctct gttcctaaaa 3320041 ccaccgcttt ttttgcggga tgcggaatct cttttatcgt ttcctcaaca atatgcaaca 3320101 taggaactga caatgcctgc tgaatctctt catagtagac atgcgccgta ttacaaggca 3320161 gcgcaatgaa atccacgcct gttttctcga gctttaccgc tccgtcgata atcgcttttt 3320221 tcatctcgtc atggtcaatt ggacgatctg catagaaggg cgtcgggcat gaatagatca 3320281 tcatgtgcgg atagtcaata tcgtttgaag ccccatacag cttctgacag taatcaatca 3320341 ccttatcaat aaacggcgag gtcgatttcg gccccattcc ggctaatatt ccgatcatca 3320401 aattcattcc tttctacttc gtacggaccg cttcttcctc tgagccatcc tcatagagga 3320461 taaagctttt cgcagcatcc tcacctaatg taaactcgac ttcaacagac aatgctcgca 3320521 gaaagaaacg ggtttccgag gaaggaaata actccagtct cagctgtccg gcgatctcca 3320581 aataaagccg ttcattctcg gttgtcacct gtgcagccgt cccatcctgc aacaggtagc 3320641 tgccaacata gcggctgtat atcgccgtat caattgcttt tttcttttta tcagcaggac 3320701 gttccgggac atcatatggc tggccaaata gaatatgttc cgccgccttc agaatcgctt 3320761 gttcatattc agtatcctct tccttattac tcaaatagat cagcgtttta cgatgatcga 3320821 tatatcggat catcatcgtc gaatagccgg gccatcctcc gctgtggctg acaatccgcc 3320881 ctttttcagg actgttttgc agcacccagc caaagccata atcaattgtt tctccattgt 3320941 tgaggcgcac tggagaaaac gcagattcct tagaagcctt gctgatgaaa tcgtcctgat 3321001 ataaagcctg atcaaatcga aacaaatcgc ttgtgacaga gttaaccgtc ccatctccct 3321061 gtatgccatc gagatacaca acatagttcg tttcctccag ctcatcaggg aggacgtatg 3321121 tttcggaatg tacatcatac acatatccat atgcataatg atcaattcgc tcaggcgaaa 3321181 gcctcctgtt atacactctt gtttcattca tgcctgccgg taaaaaaata cttgttttta 3321241 taaaatccgc atagctcatg ccagatgctt tttcaatgat aaccgccagc agcacatacc 3321301 ccgtattgct gtacatccag ccttcattcg gttcaaaata accagatagc ccctcattca 3321361 tcagcatatc gacaatatcc tgattcaccg caatcttgtg tgaatcccaa ttggcaaaaa 3321421 accatcccat ataatcagga agccctgacg tatggttcaa taaatgccga atcgttacgc 3321481 cctgatacgg aaaaccgggc agccagcgat ccactttatc ctcatagcca agaatcccct 3321541 tctcctccag caagatgatt cccaatgctg taaaaggctt tgacaaagac gctaactcaa 3321601 acaaagagtt ggttttcaac gggcgttttt ccgtcatttc cgcatagcca aaagagtggt 3321661 gatataaaat atcgccaccc tccgcagcca gaaccgtccc gttaaactga tgtttttcgc 3321721 ctaatgtctc aaataacgtc tgaagatgct ttcttttatt ctgcttcatt cctccacctc 3321781 ccatatctct gtacgttact aacctactaa cgtttcaaat attttgaaaa atccttcagt 3321841 tagagatcct ttttaaccca tcacatatac ctgccgttca ctattattta gtgaaatgag 3321901 atattatgat attttctgaa ttgtgattaa aaaggcaact ttatgcccat gcaacagaaa 3321961 ctataaaaaa tacagagaat gaaaagaaac agatagattt tttagttctt taggcccgta 3322021 gtctgcaaat ccttttatga ttttctatca aacaaaagag gaaaatagac cagttgcaat 3322081 ccaaacgaga gtctaataga atgaggtcga aaagtaaatc gcgcgggttt gttactgata 3322141 aagcaggcaa gacctaaaat gtgtaaaggg caaagtgtat actttggcgt caccccttac 3322201 atattttagg tcttttttta ttgtgcgtaa ctaacttgcc atcttcaaac aggagggctg 3322261 gaagaagcag accgctaaca cagtacataa aaaaggagac atgaacgatg aacatcaaaa 3322321 agtttgcaaa acaagcaaca gtattaacct ttactaccgc actgctggca ggaggcgcaa 3322381 ctcaagcgtt tgcgaaagaa acgaaccaaa agccatataa ggaaacatac ggcatttccc 3322441 atattacacg ccatgatatg ctgcaaatcc ctgaacagca aaaaaatgaa aaatatcaag 3322501 ttcctgaatt cgattcgtcc acaattaaaa atatctcttc tgcaaaaggc ctggacgttt 3322561 gggacagctg gccattacaa aacgctgacg gcactgtcgc aaactatcac ggctaccaca 3322621 tcgtctttgc attagccgga gatcctaaaa atgcggatga cacatcgatt tacatgttct 3322681 atcaaaaagt cggcgaaact tctattgaca gctggaaaaa cgctggccgc gtctttaaag 3322741 acagcgacaa attcgatgca aatgattcta tcctaaaaga ccaaacacaa gaatggtcag 3322801 gttcagccac atttacatct gacggaaaaa tccgtttatt ctacactgat ttctccggta 3322861 aacattacgg caaacaaaca ctgacaactg cacaagttaa cgtatcagca tcagacagct 3322921 ctttgaacat caacggtgta gaggattata aatcaatctt tgacggtgac ggaaaaacgt 3322981 atcaaaatgt acagcagttc atcgatgaag gcaactacag ctcaggcgac aaccatacgc 3323041 tgagagatcc tcactacgta gaagataaag gccacaaata cttagtattt gaagcaaaca 3323101 ctggaactga agatggctac caaggcgaag aatctttatt taacaaagca tactatggca 3323161 aaagcacatc attcttccgt caagaaagtc aaaaacttct gcaaagcgat aaaaaacgca 3323221 cggctgagtt agcaaacggc gctctcggta tgattgagct aaacgatgat tacacactga 3323281 aaaaagtgat gaaaccgctg attgcatcta acacagtaac agatgaaatt gaacgcgcga 3323341 acgtctttaa aatgaacggc aaatggtacc tgttcactga ctcccgcgga tcaaaaatga 3323401 cgattgacgg cattacgtct aacgatattt acatgcttgg ttatgtttct aattctttaa 3323461 ctggcccata caagccgctg aacaaaactg gccttgtgtt aaaaatggat cttgatccta 3323521 acgatgtaac ctttacttac tcacacttcg ctgtacctca agcgaaagga aacaatgtcg 3323581 tgattacaag ctatatgaca aacagaggat tctacgcaga caaacaatca acgtttgcgc 3323641 caagcttcct gctgaacatc aaaggcaaga aaacatctgt tgtcaaagac agcatccttg 3323701 aacaaggaca attaacagtt aacaaataaa aacgcaaaag aaaatgccga tatcctattg 3323761 gcattttctt ttatttctta tcaacataaa ggtgaatccc atatgaacta tataaaagca 3323821 ggcaaatggc taaccgtatt cctaaccttt ttaggaatat tgctgtttat cgacttattt 3323881 ccaaaagaag aacatgacca aaaaacaaaa tcaaaacaga agccggacta ccgggcggca 3323941 tatcatttta cgacgccgga taaatggaaa aatgaccctc aaaaaccgat ctattttgat 3324001 ggcaagtatc attatttcta tctatataac cgggattacc caaaaggcaa cggcacagaa 3324061 tggcgccatg ccgtctcaga ggatttggtg cactggaccg atgaaggcgt ggcgattccg 3324121 aaatatacaa acccggacgg tgatatttgg accggttccg tcgtggtgga taaagagaac 3324181 acagccggct tcgggaaaaa tgcgcttgtc gcgattgtga cacagccctc agccaaagac 3324241 aaaaaacagg aacaatattt gtggtacagc acagataagg gaaaatcatt caaattctac 3324301 agtggcaacc ccgttatgcc taatccgggc acagacgatt tcagagatcc gaaagtcata 3324361 tgggatgacc aagataacaa atgggtcatg gtcatggctg aaggatcaaa aatcggcttt 3324421 tatgaatccg ataatcttaa ggactggcat tacacaagcg gattcttccc agaacaggcg 3324481 ggaatggtgg aatgtcccga cctctacatg atgcgggcaa gcgacggaac gaataagtgg 3324541 gttctcggtg ccagcgcgaa tggcaaaccg tggggcaaac caaatacgta cgcctactgg 3324601 accggaagct tcgacggaaa agaattcaaa gcggatcaga ctgaagccca atggcttgac 3324661 tatggcttcg actggtatgg cggtgtgacg ttcgaagaca gcaaaagcac agatccatta 3324721 gaaaagcggt atgcgcttgc ctggatgaac aattgggatt atgccaacaa caccccgaca 3324781 atgaagaacg gctttaacgg cacagattct gtcatacgcg aactccggct gaaggagcag 3324841 gatggaacat acagcctcgt ctcacagccg attgaagctt tggagcagct gactgtttca 3324901 actgacgaaa tagaggatca ggatgtgaac ggatcaaaaa cattgtcgat aacaggtgat 3324961 acgtaccagc ttgatacgga tctttcttgg tcagagctaa agaatgcagg cgtcaggctc 3325021 agagaatcag aagaccaaaa acgccatatt gatgtcggca ttttcgctga aggcggctat 3325081 gcttatgtca atagagcagc cacaaatcag cctgacaaaa gcaataccta tgtcgaaagc 3325141 aaagctcctt atgatgtaaa caaacgtaag gtgcatttga aaatacttgt cgataaaaca 3325201 acgatagaag tatttgttgg cgacgggaaa accgtttttt caaatgaagt cttcccaaag 3325261 cctgaagata aaggaattac cctttattct gacggcggca cagcctcctt caaaaatata 3325321 acagtgaaac actttgattc gattcatgaa taaaaacagg ggcggcgcag gctgcccctg 3325381 tttttttatt aggagcggta ttctctgtta catattgggc attgtaagga atataaggct 3325441 ggtttcaaag gaggaagcga atgtctaaac aaggaaattt tcaaaaatca atgtcgctgt 3325501 ttgatctgat tttgattggg atgggagcca tctttggatc agcgtggctg ttcgctgtca 3325561 gtaatgtcgc ttcaaaagca gggccctccg gcgctttttc ctggatcctc ggaggagcca 3325621 ttattttgtt aatcgggctt gtatatgcgg agctcggagc cgctctgccc cgtaccggag 3325681 gcatcattcg ataccccgtt tattcacatg gccaccttgt cggctactta atttcgtttg 3325741 tcacgattgt cgcttataca agcttgattt caattgaagt gacagctgtg cgccagtatg 3325801 tggcctattg gtttcccggc ctgaccatta aagggtctga ttcgcctacc atttccggct 3325861 ggatcttgca gtttgcccta ttatgcttgt ttttcctgct gaattattgg agcgtcaaaa 3325921 ccttcgctaa ggcgaatttc atcatatcga tttttaaata tattgtgccg attaccatca 3325981 ttattgtgct gatctttcat tttcagccgg agaatttatc cgttcaagga tttgcaccgt 3326041 ttggatttac aggtattcag gctgccatct cgacaggcgg cgtcatgttt gcgtatctcg 3326101 gcctgcatcc gattgtatct gtagcaggtg aagtccaaaa tccaaaacgc aatatcccga 3326161 tcgctttaat catttgcatc atcgtttcaa ccatcattta tactgttttg caggtcacct 3326221 ttattggtgc aatcccgaca gaaacactga aacatggctg gccggcaatt ggccgggagt 3326281 tctcattgcc gtttaaggat attgcggtca tgctcgggtt aggctggctt gcaacgcttg 3326341 tcattttaga cgccattctg tctcccggag gaaacgggaa tatctttatg aatacgacat 3326401 cccgccttgt ttacgcctgg gcgcgtaacg gcacattatt tggcatattc tcaaaggtca 3326461 ataaagatac ggggacaccc cgcgcttcgc tttggctttc gtttgccctg tccattttct 3326521 ggacacttcc ctttccttcg tggaacgcgc tcgtcaatgt ctgttcagtc gcgctcattc 3326581 tttcatatgc gattgcaccc atttcttcag ctgcgctgag ggtcaacgcg aaggacttaa 3326641 acaggccgtt ttatttaaag ggaatgagca ttatcgggcc gctttccttt atatttacag 3326701 cgtttatcgt gtactggtca ggatggaaaa cagtctcctg gctgctcggt tcacaactcg 3326761 tgatgttttt gatctatctc tgtttcagca aatatacgcc taaagaagat gtcagccttg 3326821 ctcagcagct gaaatcagcc tggtggctta tcgggtttta tattatgatg ctgatctttt 3326881 cctacatcgg ttctttcgga catggtttag ggattatcag caatcccgtc gacctcattt 3326941 tagtcgcgat cggctcactt gcgatttatt actgggcaaa gtataccggg ctcccaaaag 3327001 ccgccattga ttatgataaa taaagaagca agaggttttc ttgcttcttt attctttaca 3327061 aacaaacata cacgcgataa aatgaatgag agtcagtcat tactggaggt gttcctcatg 3327121 ccaaaacaaa catcgggtaa atacgaaaaa atattgcagg cggccataga agtcatttct 3327181 gaaaaaggcc tcgacaaagc ttctatttct gatattgtca aaaaggccgg cactgcccaa 3327241 ggaacattct atttgtattt ttcatctaaa aatgccctca taccggccat tgcagaaaat 3327301 ctcctcaccc atacacttga tcaaatcaaa ggtaggctcc atggggacga ggatttttgg 3327361 accgttttag atatattaat tgatgagaca tttctcatta cagaacgcca taaggatatt 3327421 attgtcctct gttattccgg gcttgcgatc gaccactcca tggaaaaatg ggagacgatc 3327481 tatcagcctt attattcctg gcttgaaaaa atcatcaaca aggccattgc aaaccatgag 3327541 gtaacggaag gaatcaattc aaaatggacg gccagaacga ttatcaactt ggtcgagaat 3327601 actgcggaac gattctatat cggatttgaa caagatgaaa atgttgaagt gtataaaaag 3327661 gaaattttca ctttcttaaa acggagctta ggtactgctt aaaaaatgac tgggtaacac 3327721 cgctcatttt ttaatgccct aaaaatgact gacgttcatt cataaaatag agaggtgttt 3327781 catttgaatt gggttcttgt ttttattgca gggcttttag aggttgtttg ggcctcttcc 3327841 ctcaaacatg ccgattcgct tttggattgg atcatcattt ttatcttaat cgcggtcagc 3327901 tttatcctgt tgatccgctc ttatcaaaaa atcccgatgg ccgcggcgta cactgtgttt 3327961 gtgggaatcg gaaccgtcgg aacatatctg actggaattg ttctgggcga atccttctca 3328021 gcagcccaaa tgttcttttt agctttattg ctggctggca ttttaggaat gaaattattt 3328081 acgaaagaaa gcaaatctca gccgggaggt gaaaaataat ggcatggttt ttattagtga 3328141 ttgccggcat agaagaaatt atagctgcca ttgccatgaa atatatagac ggaacaagaa 3328201 aaaaatggcc gatcattgtg atgactgttg gattcggctt atccttttac tgcctgtccc 3328261 aagcgatgat cgtcctgcct gccggagtcg catatgccgt ctggactggc attggaagca 3328321 ttggtgtttc ggcggtcggg ctcatctggt ttaaggagcg gtttcagctt tcacaggtga 3328381 tttcactttg ccttatccta gccggcgtca tcggcctgcg tcttacgtca tcttcataaa 3328441 atcaaggcat atacagctgt atatgccttt gccattaagc ttcgtgatgt ttttgaagat 3328501 gaagcggcgg cgggatgagc cagcctttgt tttttagcag ccttaagtat tttgcgccgg 3328561 ttgccgcttt cgacatatga aattgcccaa acatcatggc aatatcctca cgaatcgatt 3328621 gccccatcat tttgctgcat gtcacaagac ctgcagcatt ttctgctgcc gcggaagccg 3328681 ccacatccgg atcgagaaac cgtgcaccag gcggaatatc gttaagatct gctgtcggcg 3328741 gttcaggaga agccggcggc agcgccaccc cgttttcttt caggatcgtg ctgacctgtt 3328801 tgatttcatc ttggcatttc tcaatagact cacgaagcag cttcttcagg tcgtcatcac 3328861 cgacatgatt caatagcatt tggtaattgc cgaccatttt attgcccgcc atcacataac 3328921 tccacaagcc gaatacctca ccgtaatgca tcggttcatc ctgcggattt ccgcttaaaa 3328981 tacccatgct cattctcctc ccatattcaa tattgcacat ttcataacgt gcccaagcgg 3329041 aggaacattt atgtttcagc ggaaaagatt tatgaaatga aacaaaacaa aaaagacaag 3329101 agtggcaagt tgccaaacca ttgtctttcc tgttgtttga ttggacgcac tgaagggatt 3329161 cgcaccccga cagacaagat accggaaacc attcaagtgc tttttagtat gagtcattga 3329221 ttctgtcttt aataaacttt aacgagatgg cgggatgctt tgcggaaaac gaaatacatt 3329281 ttcggggtca tatttcgcct ttatttctcg aagccgcgca aagtttgcgc cataatattc 3329341 ttttccgaag ttttcaatgt tttgatctgg aacattaaca tatgaacctg ctacatatgg 3329401 ttgcatcagc tgacgcactc tttcaactga tgcaagattt gaatcttctt gtgatttatt 3329461 tttccaacta gccgtccatt ccgtataaaa taatggatgg cgccaaaaaa aggcagtttc 3329521 gtctttaggg actctgctta tagcaccacc ccaattgata aaaaagaaat tggcttctgt 3329581 tccagtagca tcttccaaaa attttctcat gattgaaatg ggttcgtcag accaaaaatc 3329641 atgaccccat gccgaggaga atttaacact ctgatcattt ctgccaggga tgggttcgtc 3329701 agggtctaag aaatctatag catctggata gtataatgtt ttgatatctg cttctgttgg 3329761 agttcccgca tgtaataaag gttttaataa tcgaatcaat tcagttttcg aaccgaggaa 3329821 aattccttct gcatgacaca aaccatttat tttgctgtaa atttcaaggt agcatcctaa 3329881 tcgttcatct acaaacggag cccatttctg ccaagcttta aataccgttt ctaattgttc 3329941 ccacggccag ataatattga agacggttgc agttttaggg gcacgatgaa ctttgaatgt 3330001 atattgggta ttatatccaa agttacctcc tcctccgcct ctagaagccc atagcaaatc 3330061 ctcattgtga gattgatctg cgtgaataat ccttcctttt gcatctaccg ttttcagcgc 3330121 gagaaggtta tcacttataa ggccaatcga tcgtgagagt acaccaaatc cgccgcccat 3330181 cgtaattccc ccgattccaa ctgttgggct atctccaaac ggagccataa aaccgtctcg 3330241 agctaatccc tttacaagcg ggccaacggg aataccagtt tgaacggttg caatagcgtt 3330301 ttcttcatct aagaaaactt tattcatgtc actcacatca ataacaattc ctccacttac 3330361 tactgaaagg ttcttatcta aagcatggcg accgcttctg acacgtaagg gcactttatt 3330421 ctcacgagcc catttaatgg cattacttac atcgtatgaa ttttgcgcaa aaacaaagac 3330481 aagaggatag acatccacat aagggttcca attcttaata gcctctgtat agccggggtc 3330541 tcctttgaag attacacgcc ctgtcaactg tgttgatccc atatattatt tcactcccaa 3330601 agaaattcga ttcagatact aaaatatgca ggagctggat aatcgcatag acaaatgatc 3330661 tacgaactat aaatataata cgctaaggcc tttttcgtcg gtgaggtctg ctgagaaaca 3330721 tttttcaaac aattttgagc aaacttcctg tccaatcctc caacaagcgt tttttcttat 3330781 cgtttttagg agcagtgtcc agtttttttc ggagtgaata ttcgtttagg ccaaaagaaa 3330841 agagagatga agaagtgttt agtaccagag gtatacatcc atacaacaga ctctagatca 3330901 tcatatactg aatgtatgta gaaaggagac atcagctttg gcaaaatatc ggattatgac 3330961 ctttgacggc ggcggtacct taggtgcttt aagtttacaa ctattaaaca gattggctag 3331021 gcaaaacccg aagttaatta gtcgaaccca tgtattttcg ggaaattcaa tcggttcatt 3331081 tactgccctt gcattagcaa gcggaagatc tccgagggaa acacttcagt attttgagga 3331141 tgaaatccta cccgcattca gcatttcccg gccaggcgga cctgttttca accaacaatt 3331201 accctattcc ggttttatta aagcggtaag aaattttttc ccagcagatc ttcaacttat 3331261 agatttaaga aaacgaattg ttgtcccatc attcaaatta tactctcaaa aactggaccg 3331321 ttggactcct gtcttatttc acaattttcc cggctctccc tatttaaatg aaaaagtgag 3331381 tgatgtcata ctgcggagca gcggtgctcc cgcgacgcaa cgcgcctatc aaaactatgt 3331441 ggacggatat gtagtagcaa cgaatcccag tacagccagt atcgcgtttg cagttggtaa 3331501 agccaacgtg ccattggatc aaattgcggt attgtccatc ggaacaggtg aagccccgac 3331561 tcggttaaga agagatacga ggggatgggg aatggtaagt gcagataaca tacgtcccga 3331621 aaatctgaag aaccttcctc caaattgggg agtccttttg gacaggtcgc ctaatgaacc 3331681 tttactgcca tttcttcaga tgattgctgg cggtaatggg tactatgaat ccatggtcag 3331741 tgcgaatctt ctgggagatc gttttttccg gttagatccg cggattccga acttctccaa 3331801 aacggaccct gccgtcgttc ccgctgtcat tgaaattgcg aacaaaacaa acttacagcc 3331861 tgcgaatcaa tttatagaga agaactgggg gagcaaataa ttatttattt taaatcaatt 3331921 ctcgcttata caattttgtc cgagagaaga ttctcaaaat aaatacaggc aatgggtaga 3331981 accggatttt tttaaaggtt tgttaatcac aagctaataa gatgaatgaa aaaatcaatt 3332041 catacttctt cttttgaaag tgagggttca aactaaagaa tgtaattgaa atgttactct 3332101 aaggtatgca attccctttt tcacacaaaa aaagacaaga gcggcaaatc gccaaaccct 3332161 tgtctttcct gttgttctat tggacgcgct cggagggatt cgaacccccg acagacgtgg 3332221 taccggaaac caccgctcta tccaactgag ctacgagcgc atatagactg cgttatgaga 3332281 acgtcagcac aactaattat acgataattc ctttcaaata acaaccctct atttcgagag 3332341 gccgtttttt aaatagacaa agcatcttaa ttggcaatct gacatacgat ggtttgaacc 3332401 cctgtatttt tggggaaaat gggaaaaaga gacgactttg catatcaggc cagctttttg 3332461 tttgaccttt attgaccaaa aatgtatcat gtaactacat acttacctaa aaggtgaagg 3332521 aggagcatta tgaatttaat acctacagtc attgaacaaa cgaaccgcgg ggaaagagcg 3332581 tatgacattt attctcgtct attaaaggat cgtatcatca tgcttggatc tgcgattgat 3332641 gacaacgttg cgaactccat cgtgtcacag cttttattct tagcagcaga agaccctgaa 3332701 aaagaaattt ctctttacat caacagcccg ggcggctcta ttacagccgg tatggcgatc 3332761 tatgatacca tgcagtttat taagccgaag gtatctacaa tttgtatcgg tatggctgcg 3332821 tcaatgggcg cgttcctgct tgcagccggc gaaaaaggca aacgctatgc gcttccaaac 3332881 agtgaagtca tgattcacca gcctcttggc ggtgcgcaag gtcaagcgac agaaattgaa 3332941 attgctgcga aacgcattct cttgcttcgc gacaaattaa acaaagtcct agctgaacgt 3333001 actggccagc cgcttgaagt gatcgaacgc gacacagacc gtgataactt caagtctgct 3333061 gaagaagcgc ttgaatacgg cctgattgac aaaattttga ctcacacaga agacaaaaag 3333121 taataacaca acctgcaaga gctgcgtctc ttgcaggttt ttttcatttc aaggaattga 3333181 ctcccttatt ctatactgct cccattcctc atgtaacagc tcaagcgtca aatcactcgt 3333241 ctgcctcaca accagatcag caccaagcat cggctgtcct tgaccgacac caaccgcaaa 3333301 catccccgca gatttgattg cagaaatgcc tgcttctgcg tcttctattg ccgcgcaatc 3333361 agcaggggaa acatcgagca tcgctgcagc tgttaaaaag atgtcaggat caggcttccc 3333421 cttcgcaaga gtcgtcggat caacaatggc atgaaaatca tcgataattg ccaagcgtct 3333481 taaaatctta ggagcattgc gacttgaaga tgctaacccg atttttatat tttcgttttt 3333541 caattgacat agaagcctgc caatccccgg taaaagatct tccggcgtca atttgctgat 3333601 cagcatttga taatcgcgat ttttccgatg cataagctct tgtttctccg catttgtata 3333661 ctttgtttcc gccccgccaa agatcaatat gctttcaagt gactcttctc tgctgattcc 3333721 ttttagcctt tcattcatgt ctctgtcaaa agggatatcg atttgttctg cgatgtgctt 3333781 ccaagcgaga aaatgatatt cagcagtatc tgttatcact ccgtctaaat caaaaatgac 3333841 cgctttcata tactaatgcc catcacagct tcataaggtt tgaggctaat actctttaag 3333901 tcagcccgct cctgcggata gtttgaaatt agcactttcc aacgctcatg aatcagttct 3333961 ggaggcgctt cgaacagagc cttttcttcc gataaattca caacgacaag aagcttttcc 3334021 cctcgatatt ctcgaaggta agaaaagacc tgcggatcat tctcctgcaa cagctgataa 3334081 tcgccatata tcataatctt atattgcttt cgtaattgaa tgagcttctg atagtaaaag 3334141 aaaatcgaat cttgatcttc caaagactct ttcacattga tatcttgata gcgggaattt 3334201 accggtatcc acgggtctcc ggctgtgaat cccgcatgtt ttccggcatc ccactgcatc 3334261 ggtgttctcg catgatccct tccttttatc atcacggctt tgacaaactc tttttctgac 3334321 atcgttttgt tttcgacgac tagttcacga tatgcattct ttatttcaag atcatcatac 3334381 atctccagcg gcatatcgct gttgaccatg ccgatttctt ctccctggta aataaacggc 3334441 gttcctttca tgccgtgcag aaccgttgca aatgccttcg cacattcctt acgcagtttc 3334501 ctgtcattgc cccagcggga aataaccctc ggctggtcat ggttctcaaa ataaagggta 3334561 ttccagccga cattcattaa cccggtctgc caccttgtca tcgtcttttt taaagcaatc 3334621 aaatcaaacg gcttgatctg ccatttccca tttggcgagt tttgttcttt atcaatatcc 3334681 atatgttcaa atgtaaagat catattcagc tcttgcctgc ttgcatctgt gtactttttc 3334741 gcctcttcaa tatcagagcc gtttgcctct ccgactgtca tgcagtcgta atgagaaagc 3334801 acttccctgt tcatctcttg aataaactca tgaagacgtg ggccgttaga gtgataacgg 3334861 ccgacaatat agctgcggct gtgatccgtt tcgtagtccg gaaaatcggt gtatttagaa 3334921 atagagccaa tcacatccat ccgccagccg tcaacgcctc tatccatcca gaatctcatt 3334981 acatcataaa cttcccggcg aacggcttcg ttttcccaat ttaaatcagg ctgttttttc 3335041 gaaaagtagt gcaaataata ctgccctgtt ccttcatcgt atgtccacgc tgagcctgaa 3335101 aagatcgatc cccaattatt cggctctgag ccgtccggtt taggatcttt ccaaagataa 3335161 taatcccggt aaggattgtc cttcgacttg cggctttcag caaaccaagc atgctcatct 3335221 gatgtgtggt tcacgaccaa atccatgacg attttcattc cgcgtttatg gacttcatca 3335281 atcagctgaa acatatcttc atttgtccca aacttttcgt acatgttttt gtaatcgctg 3335341 atatcatatc cgttgtcatc ctgcggggaa tcaaataccg gggagagcca gatgacatcc 3335401 gccccgaggt ttttgatgta atccagcttt tgaatcacac cttgcaaatc tccgaatcca 3335461 tctccattgg catcataaaa actgcgcggg taaatttgat aaacgacagc ttctttccac 3335521 cattcactca ttaggcgttc tcctttcaca tcgtccctgt aggacaaccg gttcctcata 3335581 aacgttcatg tgcagcggct cgccttttac aagctcaaaa ataacgcgct tttcgtcaac 3335641 cgtcacattg attaatcgat ttcgataatt gatgttgaat gaatattcgt cccattcttt 3335701 cggcaaaaac ggagcaaatg acagcgtctc attcgcggtg cgcatgcctg caaagccatg 3335761 aacgattgcc agccagctac ccgtcattga agtaatatgc aagccttctt ccgtatcatg 3335821 attgtaatta tcaagatcaa gccttgctgt gcgcttatat aattcgagcg ctttcttttc 3335881 cagcttgagt tcggctgcga gaatcgcatg gacagagggc gataggcttg attcatgaac 3335941 agtcatcggc tcataaaatt caaaatttcg ccgtttttct tccattgtaa aacggtcatt 3336001 aaaaagataa atgccttgga gaacatctgc ctgcttaata aaattggagc ggagaatctt 3336061 gtcccatgac caattctggt aaagaggccg ttccgctgga tctaattcgt caactgtttg 3336121 caggtctttg tccaagaacg tgtcatgctg aacgaaaatt tgcagttctt cactaaatgg 3336181 atagtacatg tgctggatga tttctctcca gacttccaat tctacttcct gcacatccag 3336241 atggcggcgt ttctccgctg agatactttc gagactttgt agagtatact ccaacgtcca 3336301 agccgcaatg acattcgtat accaattgtt gttaacgttg ttttcgtatt cattcggccc 3336361 tgtgacgcca tggatcatat acttattttt tcgtttcgag aagtgaacac ggtcggccca 3336421 aaatctgctg actgccacaa gtacgtctat cccgtattct tccatatagt tacggtcgcc 3336481 tgtataattg atataattgt agatcgcata acagatcgcg ccattgcggt gaatttcttc 3336541 aaaggtgatt tcccattcgt tgtggcattc atcacctgtg aacgtcacca tcggataaag 3336601 tgcccccttc atccccaatt ttgcagcgtt tcgtttggca gcctccaact gatgatagcg 3336661 atacaaaagc aggtttttcg tcacctccgg ctcggctgtc gccaaataca tcggaacggc 3336721 gtacgcctca gtatcccaat atgcggcacc tccatatttc tcgccagtaa atcctttcgg 3336781 cccgatattc aaacgggcat cgcccccgta atatgtcgag aataactgaa agatattgta 3336841 gcggattcct tgttgaagct cctcatctcc tttaatctca atgtccgctt ttgcccatct 3336901 ttccttccat cgatcagtgt gcctccgttt tgcatcttca tagccgttct ctaccacatc 3336961 cgccaaaagc tccttggctt tcgataaaag ctcttcctcc cgaaaatcac gggaagtcgt 3337021 gacaatcaca aactttttca atgatgcctt cgtttgataa ctgtagcgat tctcgacata 3337081 catttcagtc gttttaaagc tttcatggac aaaaccctcc gtctcgtttg ccattgcggc 3337141 taataccgtg aagcgcggtg ttccaaatgg attttcgatc gtttttgccg ctaaatggcc 3337201 gctgtgagaa tcagcacctt tcgcttcctc ctgccaaaac tgttcttggt agttagaatc 3337261 ttcatttgcc acatttccat ccaggtaagg aacaagcgta atgacagcat ctcccgtcaa 3337321 gcactccgct tcataatgaa tcgcacagag ttcttttaca gcaaggctaa gaaaccgctc 3337381 tgacctgatt ctgacggttt tatcttgaat gcggacaaca gcgcttcgcc gcagaatccc 3337441 ctctttcata ttgagttcta cctcaaataa ttcgattggg ttttgatgga gatcgatttt 3337501 ttcaccgtca acatataggc ctatgcccat aaagttcatc gcattgatca cttttccgaa 3337561 atattctgga tacccgtttt tccaccagcc tactcgcgtt ttgtcgggga accacacgcc 3337621 tgcaatatat gtgccttggt gactgtcgcc tgaatagcct tcttcaaaat tccctctgac 3337681 ccccatatag ccattggcaa gagacgtcag gctttccagc agccgtgtat gctccttatt 3337741 aaatgtattt gttttgattt tccattcatc aatctcaaat aaccgctgat ttatcatcat 3337801 ttcctcccga atgtaagttt ccattatcac ggcgggtttt ggtcaaatat ctaaatgcaa 3337861 aagagatcat caaagtaacg ccacacgaat ggatcatcaa tacagtaatc aaatcaaaat 3337921 gaaccatgcc gatagcagct gccgcaaatg ccggcagtgc tgatgcgcaa atcgctatag 3337981 aggccgcttc cttgaatgat gcaatagaga ccatgtttga tatttttgtg atccagaggc 3338041 cacctgcaag aacaaacgtt aacaaaagct ggatcataga aaccaccgta tatgccagca 3338101 tcatgatcat cggcttatac tgtgccaacc acaatgtatc gatcaagacc tctacatcat 3338161 ggacgtttgg tttctcgagc ttaacgtcca ttttcgcata gccaacagaa aaccccgttt 3338221 cgttttgatc ggtgatcacc agttgatcag gttgaaatat gatggcgttt tcaaatccag 3338281 ttactttcaa tcgcccattt tcaccgcttg tctcatattc atgcttcata tcgactgcca 3338341 tcacattctg cccatcttca atcctctcag agctcttccc gcctgttagt tttccgttcc 3338401 tgatttgaaa accctgcaat tgatcagcaa attgatcatt aactccttga atcgctgacg 3338461 gcatgaaaga tgaaacgctg aagcgatcca ttttcacaaa cgaaaccgct aacggcgcca 3338521 ttaagcaggc cgttaaaaac agaaagagaa aagagagctg cagccagctg aaggtattcc 3338581 catagcggca aacacctgat ggggatgcag ccgccttcag gcagcggatg ataaagcttt 3338641 tattctccag attcttcatt ggcattaccc ctttgttccg ccggctgtca aaccggacac 3338701 aaagttcttt tggagaaaaa agaatagaac gcatatcggc agtgcggcta gtatggcacc 3338761 ggctgcaaat agagctactt tttgctgctg cggattagaa ataaaggatt gtaatcctac 3338821 agcgatggtc agcctttccg gtgagcgaag cagaaatttc gtcagcaaat agtcgccaaa 3338881 cggtgccata aacgcccaaa gcgcttgtac cgcgagcatt ggcttaacaa gcggtagaac 3338941 aattgaagcg aaaatcctca gatgtcccgc tccgtcaatt cgcgcggctt catcaatttc 3339001 tctcggcaca gtatcaaaat aacctttcat cagccacgtg ttcatcggaa ttccgccgcc 3339061 gatatagatc gctgttaaaa accagtattg atcgagtgcg cctattagca tcgccaagac 3339121 ataaaaagca gtcagcgccg ccattgtcgg caccatttga atgattaaaa agaatatcag 3339181 gctctttttt ctgcctgcaa accgatagcg gctgtacgag tacccggcaa gtgtcacaat 3339241 cgtaacctgc aaaaccatga ccgatagcgc gatgacaagt gtattgctgt accaattgag 3339301 ataaagcgtt tcgtcaaata gccgcttaaa atgatccaat gtccaagaac ccgaaaaatc 3339361 gagctgaaaa gccgccgaat tccccacacg gaaggctgat gatgccgtaa tcagcaacgg 3339421 atatataatg acaatactta aaagcgtcaa aaataaatac gtacagattt tattaagcat 3339481 tctggcagtg ctcgcgttca cctacataac ctcctcattg ccaaaagcat tcgatttttt 3339541 gaaagcaatc agtgaaattc caatgacaat gaaagaaatt aacagtgtca cagccgccgc 3339601 aacggaatat tggggtgatg tgcctgttgt cagtttataa atccacgaaa ttaagatatc 3339661 ggtcgatccg gccccggctc ccgcactgcc tggccctccc tcattaaata aatagatgat 3339721 cgagaaatta ttgaaattaa acgtatactg agtaatcatc acgggtgctg tggcaaataa 3339781 aatcatcggg aatgtaatat gccgaaaacg ctgaataaaa gtggccccgt caatctttgc 3339841 cgcttcatac aattcacctg gaatcgcctg aagcactccc gttaccatga catatatata 3339901 tggaaagccg agccacgttt gaatcataat gagggctgtc tttgtccaga aaggatcggt 3339961 cttccacgcg atcgcaggca gctcgacaaa cggcaggtga ttgaataatg gtatcacctg 3340021 tgcattcacc gctcctatgc tgtcgttaaa catgttggaa aaactcatga ttgtaataaa 3340081 cgccggaaca gcccatggaa ataagaaaat cattcgaaat atccgcttgc cttttataaa 3340141 atcctgattg acgaaaagtg ccgtcacaat acctaaaatg atttgcagcg ttgttgcaca 3340201 gattgtccag ataaccgtcc agcccagtac attcacaaat gtttcacgat aggagccaag 3340261 gaaaaaaata tttaagaaat ttttaaaccc gacccagtca atcagacgat taggcggaat 3340321 atgataaaaa tcatagtttg ttaatgcaac aaacagagtc accaaaaccg gaaaaataat 3340381 cacaaacacc atcatgatat atgccggcag tgtaaataga tacggaaaac ctttatcgcc 3340441 cgcatgacag atcatatcct tggctgttgt attgacttcc aaacccgccg ctttcatagc 3340501 ggcggtctta cgtgaatcat gaatattaaa gatatagaac atgaggaaaa tcattgtcac 3340561 gatcaattgc agcgtgcctt caatcagcat aaacagcgag tgatcttcac cgggaacact 3340621 tcccaatgtc atcaatccgg ttagcgcctg tataccgaaa acgcataatt caaaagcaaa 3340681 caagcctgtg atggcaagaa ataagagccc ctttgacaac tgctgattcg caatctgccc 3340741 aagtcctgga atgatcgata aaagccctgc ctttcgtttt tgctttgtaa gtgtgtgatg 3340801 tttattcatt tttccgccct ctattcttcc ggacgctatc ccgccgtttt atttcacata 3340861 cttttcttta atattttcct ttatgacgtt tacagcatca ttcgctgatg tttgtgtcga 3340921 tttttttcct gaagctgcat caaaaattaa actttccgct cctgtccata cttcagccat 3340981 ttccggaata tttggagtcg gcgttgctgt ttcatattgt ttaatcacag ctgacgtcag 3341041 ttcattcttt tgctcatcgg ctttcttcct tgcagccgtg ttggccggaa cttcgtttgt 3341101 atcctcataa aaagcgtaag cattggcatc atttgcagca tactcaagcc atttttcagc 3341161 cagctcgggc tcttttgtat atttcgaggc aacccagccc ttcccgccag caaaaggggc 3341221 gtattcttct ccatttggca atgtcggaat gggagccgct ccgtagttca atttagcctc 3341281 tttatagttg gcagctgacc aaggaccgcc aatgatcgca gccgctttgc cttctaaaaa 3341341 catctgctga ataaagtcgt ctgcgcttga attgtcttgc attcctttcg gccaatatgt 3341401 ctcaaaccat ttctccgcat atttcaccgc ttctacagcc cctttattgt tcaggccgat 3341461 gtccccggaa tctgtgccgt tttttccaaa cacatatccg ccgtatccag ccaataagcc 3341521 gtacgacata taaaagtcag tccattttgc taaaaatccg gttgattttc ctttttccga 3341581 agcaaacgcg aatcgaggat cttccgttaa cttttcaagg tctttaaatg tttttggcgc 3341641 tgtttttaaa agatctttgt tgtaatacaa aataagtgtc tcaatgacta gcggcattcc 3341701 gtacactttg ccgtcaactg tcacctgctg catttcttta tcaccaaagc tttttgtgtt 3341761 agatggctta atatcaagta aatgtccttg ttgtcccaaa ccgccgatcc ggtcatatgc 3341821 agcaagcata acatcaggcg cattacccgc cgggccatca agaggaagcg cttctaactg 3341881 ttcgaacatt tgcttttcaa caatttttac tgtgacatca ttttcttttt cgaactttgt 3341941 ttttatgctt tcaatgtatt ctttatacgt ttcttcgaca gacacagtca gcaccttttt 3342001 gccatcagag cttgctggat tttttgaact tgagcaggcg gcaaggccga ttgccaggaa 3342061 tgatgccgcc aatatggcga accccttttt taaaagaacc atctcttttc ctccttctat 3342121 ttacgaaact ataacaattg tattgtccta tagaaagcgg ttacaacaac tttcgatttg 3342181 ttaccgataa cagaatgtta tacaggggcg gcagcactca aaatcaaaaa ttctcccggc 3342241 tgaacggcaa tgacatcgtg atgctgtagc ggctgctctg tccatgcatc acagattttc 3342301 ttattcctat caatattcaa ctctcgtaaa ctgacgtgtt gaaccacatt cccttgatta 3342361 aagaaataaa tcagtatttt ttcatcaaga gtccgcgaaa agctaatgaa atcatttttg 3342421 tcgtccagca gattccactc aagatgtcct tcagtcaata aagtgttttc ctgcttgcgt 3342481 aaagcaatta accgtttcat aaattgcagc atgtcttggt tttgcttctc tttttcccaa 3342541 accatacatt tccggcataa tggatcattt tcgccgttca gcccgatttc cgttccgtaa 3342601 taaatgcatg gtgagcctgt ctgggcaaac ataaaggcca gcaacgcgcg tgctttcttc 3342661 tcatcattgc ggcatctggt caaaaggcgc tttgtatcat ggctatccag taaattaaac 3342721 atcacctcat tggcctgctt cattccattc atcaaatgtg cattgacacg gtgagccata 3342781 cgtgaagctg agatcgtctg gtcagcaaag tattcaatca taggctctgt aaaagggtaa 3342841 ttcatcgccg catgaaattc atcccctcta agccagggtt cggcagaatg ccagatctca 3342901 cctaaaatat aaacatcagg cttttcagta gatacagcct gcctaaatgt cttccaaaaa 3342961 acgtgatcca cttcatttgc gacatccaaa cgccagccgt caatgtcaaa ttcgcgaatc 3343021 cagtacaaag caatatcaag caaatatttc tgcacctcgg gattagccgt gtttagcttc 3343081 ggcatatcag ctgtaaaagc aaatctgtca taattgtcgt ctgtgacggg aaaagagtga 3343141 atatggaacc agtccttata gcgggattga tctccgtttt tgacgacatc ctgccattgc 3343201 ggagacgcgc ttcctatatg gttaaaaacc gcatcaagca taattctcat cccccgctga 3343261 tgcagctggc tgaccaatgt acgaaaaagc tcaggatccc cgaaatgcgg atcaatagaa 3343321 aagtaatcca gcgtgtcgta tttatgatta gaaggcgcgg aaaagatcgg tgtcagataa 3343381 atgccgttca cccctaaatc ctctaaataa tcaagcttgt caacaattcc ttgtaaatcc 3343441 cctccaaaaa aatcattgac gtccgggtcc ttgctccccc acggcaatgc attcttcggt 3343501 gacaagtctt ctcttccatt tgcaaaacgc tccggaaaaa tttgatacca aaccgttgac 3343561 ttgacccatt caggcgcttg aaatgtatca gcctcgtgaa caaacggaaa tttaaagtaa 3343621 taatgaatcg tttccagtgt tttttcgtta taagggcata cacccgaact tccgaaaaag 3343681 atgtcttcat gatcgtctgt tacaacaaac gcatattgta aacgcctaaa tggcggcacc 3343741 acttcagcaa accaatagtc atgcatttct gtagcagcaa ttttcctcat cggctgctcg 3343801 tttgccgacc atttgccgtc gttgtactca tagggatcac cccaaatgaa tcgaatgtga 3343861 tctgcatcac cttttttcgt ccgaatcttg atatgcacag tccgcccatc ataagaataa 3343921 gcatctgtgc tgaatggctg gtgatgaatc gctgcatatt ccatcatgtt tccccctttg 3343981 atttccgttt tattgaagcc ggctcatagt ttgaaagtat catgatgaaa ttgtgggaac 3344041 aatccttttc accctgttac cgataacaga ataaggcgct tacagcgttg attctcgtac 3344101 aattaactct ggttcaaaaa atagacttcc ttgtgcagcg ccgtcttcat tcattttttt 3344161 cagcaacatt ttcgcacagg cttcccccat ttcaacaaca ggctgtctga ccgtagtcaa 3344221 gcgcggcgag gagatgcgat caagaaacac accgtcattc ccggtaaccg caacgtcttc 3344281 tggaattcgc tttccaaggg attgcgccgc acgaatgacg ccgagcgcga ttcgatcaga 3344341 tgcgcagaca aatgcggcct gattgtccat ggatttcagc agttctcttg caaggcattc 3344401 acttttctta gaactgttgt cgatccgaaa catattcgat tttttaaagc ttttattcat 3344461 cgcccgtata tacccctgtt ctcttgcacg ttcgaaaggc tcatctaaat caatgccaaa 3344521 aaagacaact tcccgctccc ccagccccat aacatggcgg gttgccataa aagtgccttt 3344581 ctcgttattc acatcgataa agtcatagcc catttcattt tgtccaaata cgacgagcgg 3344641 cttctcaaaa gcttttatta caccttcaaa atcgttcttt ctcaagccgg tggcaataat 3344701 gccgtcacat tggccaatat taagagaatt tcttgtcaca agctggagag catagtgatt 3344761 gcgatccagc tccctgctga ttcctgtcag caggttcatg taatatggtt ctgtcgtatc 3344821 catttcctca agtatcaata gtttcacaac ctgtgttctg ttttgcacga gcgctctcgc 3344881 cgcataatta gggatgtaat tcagctcttt catcgcagaa tgaacaagct ttttcaattc 3344941 atccgtcacc gtctcagggt gattgatcac tcgtgatacc gtcattttcg aaacatttgc 3345001 ttttttcgcc acatctgaca atgttgccat tttcatcccc tccttatctg tgcttattat 3345061 ccaaactagt gataaagtcc tctattactg ctaaatatac gatgcaggcc aaagagaaat 3345121 aaaaaagaga tttcccttaa ggaaacctca ctttgttaaa aacactcgat ttttcatgga 3345181 ttcatacgct aggtggcaga ctcattctct ccacttccat cagaaaatct cttttttaaa 3345241 tttctgtcca ctttttttct aaaatcggat aagaataatt ttgcatttgc tcaattaact 3345301 catccggccg tgacgagctg tgaatcagtt ttaggtgcga ttcgttagaa aacccttctt 3345361 gaatgctgta tttcaccatt ttcatcattg gttcaaaata tccgtttaca ttgtacagtc 3345421 caattggctt ttggtggatg ccgatctgtg cccagcacag cacttcaaat aattcttcat 3345481 atgtaccgaa gccgcccggc atcgagataa agccgtccgc cagctcgctc attttagcct 3345541 ttcgttcatg catcccgttt acttcaatca gctcagtcag attctgatgg acaacctccc 3345601 cgctgaacaa accgctcggc atgaccccga ttgcagttcc gccgttttcc ataatcgcgt 3345661 cagcaatcgt gcccatcaag cctacgcggg agcccccata gacaaggccg attccctgct 3345721 cagccatata cacgccaagc tctgccgctt ttcttttata cgcttcattt cccccagggt 3345781 ttgatcccgc aaatacacaa atggttttca tcttgtcatc tccgcatcta tatatcgtgt 3345841 taaacattca aaaacacact atatattgtc ccatcttcat gtgataatat caatatgaaa 3345901 tacataaaga atgcaggagt gatgaggttg cagctggctg atgcagaaaa atggatgaaa 3345961 gagttttacg aaaaaagagg ctggacagaa tacggacctt ttattcgcgt cggcttttta 3346021 atggaggaag ccggagaact ggcccgggct gtcagggcgt atgaaatcgg cagagaccgg 3346081 ccggatgaga aagaatcgtc acgcgctgag caaaaacaag aattgattga agaaatggga 3346141 gatgtcatcg gaaatatcgc cattcttgct gatatgtatg gtgtctcttt agaagacgtc 3346201 atgaaggccc accaagaaaa actgacaaaa cgatttgagc atgcataaaa aagcggccgc 3346261 gatggccgct ttttttaacc tgtgatttca tcatggtgat caaagaaatg ctgctttcct 3346321 attttgtgaa aaaggcctgt tttatgcagt agctccttcg gctgcgattg caatcctaca 3346381 atcatcagct ttccattgtg gcgtttaatt cgattcataa tgttcccaag caccgcttca 3346441 gctgacgtat ccatatagtg caccttattc atgagcagaa taagggtttt cggttttttc 3346501 tgtacatgct ccagcaatga cgattcaagg gaatcaattg atccgaaaaa cagcggccct 3346561 tctatggcat acatgctgac agatggatct tctctcttcg ccagaacagg atgcgtttcc 3346621 tgattgtgga tgcgggtcgc ttcgctcatt cttctgataa agaacacgaa tgcaagcagc 3346681 aatccggttg ccacaccgat gattaagtca aacagaaccg taagggcgaa ggtcgccgcc 3346741 aaaataaagg aatcagcatt tttcagtctc agcatgtttg cgacttcctt gcgctcactc 3346801 atattccatg cgaccaccat gagaatcggt gccatactgg cgagcggcac atgggacgca 3346861 taaggcgcaa atacaagcag gacaaggaga acgactacgc cgtgaacgac gccggaaact 3346921 ggggaaaccg ctccgttttt tatattggtc gccgttctcg caatcgctcc tgtagccggg 3346981 attccgccaa acaggggcgc tgccatattc gcaatcccct ggccgacaag ctccttgttg 3347041 ctgtcatgct ttgagccctt catgttatca gcgaccattg cggacaaaat cgactcaagt 3347101 cctccaagaa gcgcgatgac aagcgcagcc ggaaacagca taaccatttt atccaaagta 3347161 agctcaggaa actgaaattc cggcaaatgg cgggggattt ctccataagt tgacccgatc 3347221 gttgccatgc ggtcagggaa aaagacaacc gcgaccactg tggaaataag aagcgccaac 3347281 aaagcgcccg gcactttagg catcaccttg gcggatacaa gcaaaatgac gagcccgatc 3347341 acagctgtca aaatggcata cacgttaaag gtgccgagct gctgcacaat ttcaaacatg 3347401 ttgtgatgaa agttctcatg tttttcaaca tttctcaatc cgagaaaatt agcgatttgt 3347461 tccgtaaaga tcagcacggc aattccggct gtaaaaccga cgataacggg tttgggcacg 3347521 aatttcatta tttttccgag cttaaacagc ccaaacagta ccagcatcac tcctgccata 3347581 aaccccgcaa tcagcagatt ttccaagccg tactgcatga taatgccgaa taaaatcggg 3347641 acaaaggcgc ccgtcggacc gccaatctga tattttgatc ctccaaacaa agaaatacaa 3347701 atccctgcta taacaacagt gtatagccca tattcaggct cgactcccga ggcaatggca 3347761 aacgccattc ctaaaggaat tgccacgaca cctactacga tacctgcaat caagtctttc 3347821 tgaaatttct gcaaattgta tcccttgaat ctccctgaga atcgcatatt ttgttataac 3347881 ctcccttatg agtgattgtt tataagctca gtttcataac cgttaatgac cacatcaagt 3347941 tttcctgttt cagggtgaat gacaagcccg tgaaccggca cttttttcgg aagcagcgga 3348001 tggttcttaa tcatgttcac actgtgggaa acgctttctt ccacgctgtg aaaaccagtc 3348061 agccacgttt tcaaatcgag tccggcactc gtcagcaaat tcaggcagct atcctccacc 3348121 ccgcgttcct ttgctttctc aagaatcgag gacgcattca gccctgacat tccgcattca 3348181 tgatggccga caatgcatac ctcttcagcc tgcaattcat aaatcgcgac cagtatgctt 3348241 cgcatcacgc ttccaaatgg gtgagaaacg atggctcccg cgttttttac aattttagca 3348301 tcaccgtttt taagccccat tgcttgcgga agaagttctg taagccttgt atccatacag 3348361 gtgacaatga cgagcttttt cgaaggaaac tttgtcgttt tgtacggttc atacttcttc 3348421 tcactgacaa accgctgatt gtgttccaaa attgatgtta aagaaaccat ttgattcatc 3348481 tcccatccat atgattttgc aagccttctt acccagctta cagtaaggaa ttatagcata 3348541 ggaataagcc aagaaaaggt tttcaaaaaa agacactata attggactgt agaatcaaaa 3348601 cataaacatt tatatctttc aaagataata aaatttatat ttaatgcatc ctataatccg 3348661 gctgcagttc gtatatcgat gatttgtctg acaaaaaata tgggtgaatt ctgataatta 3348721 aaaaactttt ttaagcagat ttagctgttc gatcttcatt ttaagttcaa aagaaccaga 3348781 aattaaaaaa acgcagctat atttttaaca tctatttatt ttcgatataa tgaattagac 3348841 aacagccata aagggggagc cttgttgaaa ccatttgtat ttatcacaaa accgattcct 3348901 gaagagattg aagcattcat cggtgaacat tgccgttatg aagtatggca ggaggatacg 3348961 cttccgagtg acgtgctatt tgaaaaatta aaagaagcgg aggggctttt aacatcaggg 3349021 acgtccggac cgtcaatcaa tcgtgagttg ctggaacacg cgcctaagct caaagtggtc 3349081 agcaaccaat cagtaggcta cgataacttc gatatagaag caatgaaaga aagaggagtc 3349141 gtcgggactc atacacctta tacactggat gacacagttg cagatctggc tttttcactg 3349201 attctgtctt ccgccagacg tgttgccgaa ctggaccgtt ttgtcagagc aggaaaatgg 3349261 ggaaccgtgg aagaggaagc gcttttcgga attgatgttc atcatcaaac gttaggcatt 3349321 atcggcatgg gcagaattgg agaacaagca gcgagacgcg ccaaatttgg ttttgatatg 3349381 gaagtgcttt atcataaccg acatcgcaaa caagaaacag aagacagcat cggcgttaag 3349441 tatgcagagc ttgatacatt gctggagcaa tctgatttta ttcttctcat tacgccgctg 3349501 actgatgaaa cctatcacat gataggagaa cgcgaattta agttgatgaa gaattcagca 3349561 attttcgtca atatttcccg gggaaagaca gttgatgaaa aagcactgat tcgcgctctt 3349621 caggaaggct ggatcagggg agccggctta gatgtatacg aaaaagagcc tgtcacccaa 3349681 gataatccgc tcctgcagct ggataatgtc acgctgcttc ctcatatcgg ttcagcaaca 3349741 gctaaagtgc gcttcaacat gtgcaaacag gccgccgaaa atatgctcgc agcgatccaa 3349801 gggcaaacac cgaaaaatct tacaagagaa tttcaataaa tcaaaaatcc ggtctgataa 3349861 cagaccggat ttcatattac atacgctgaa gaacagcacg cttataaata tgacgggtga 3349921 cgatataata aagagcctgg aatacaaaat aaatgaagat gacaattacg gcctcaagaa 3349981 ataaattgga attcagcata ttacttaacg ctgcatacgc aaagcccgcg tgaatcgtac 3350041 ctgcgataaa tgggatgaag aataaaaatc ctatttgctt tccaaggatc gagtgaatct 3350101 ctttgtccgt aacccctatc ctctttaacg ctaacacctg cactcccgta tcttctattt 3350161 ccgtaaacat ccgcaaatac agcatgcttc cttgcacgat aaaaaacagc acgctgacaa 3350221 acagaccaat aaacagcatt aatgcaactc cctgcttcac aatttgataa ctaggagcac 3350281 gtgtttgaaa atcagatgta tgttctttcg gcaccatgtt ttcaagcttt tcagagacat 3350341 ccaccgtctc ctgccaatgc tcaagctcat aacctaccat tctcatctgt tccttcagcg 3350401 gcacatcctg tgacagactg tcaaagctct tttcgctgac aaccaataaa cggctgactc 3350461 catcgacaga catcaatatc cctttgtttt gctgcttttt catgacatag gaaagggttt 3350521 ttcctgactt catatgaaat gctgctgttt ccccttctcc aaatgtgtct ttcaccatca 3350581 tttgaaaaga aacattaata aatgcttcat tttcttgtaa atgaataact gggaaccctt 3350641 tttcctttgc gacttgatta tagacttttt ctgaaatcag caaagcttca gcttccatct 3350701 tcttatttcc atacggcaag tctgactgaa aagtgacagg aatccctgtg gcatccacct 3350761 tatacgtgat aacagcatga gcttttttca atgtattctc agccgtctca ggcttcatga 3350821 cctgaaagcg ggaagcatcc ttttccaccc aggaaacaga ctgaggaatg ctttgctcct 3350881 cctgcctttg taaatcggaa taaaacatat agatgacacc tgtagctgtt agtatgaccg 3350941 ctgtaatgac agaggttaaa aacagcatgc gtgcatgatc cttcagcctg aatatcatgt 3351001 tggaacgcac aatgatattt gtgcctttgt agaagctgtg tttctttcgg tacagcatgc 3351061 ggaaaaatgc cacactgctt tgggtaaaaa agaaatacgt gccaattaac actaaaatca 3351121 aaattggaaa aacccgaaac atcatgtcaa ttgcattggc tgttgcagat agataataac 3351181 cgctgccaag acatagcaaa gacaatacag tgagccattt cgaataaact ggcaaacttt 3351241 tcggcttttt ggctgattta atcagttcaa tgatttccag cttccgaatc cgtcccagtg 3351301 ataaaatgag cagcgtctga aacaggatga gaaagccggc aattgtcatc acaaacgctt 3351361 tcggcacaat ggcaaacgaa atcggcacct tcacgctgag catccatgtc atgatcataa 3351421 aaaacagttt tgaaaataac aggcctgctc caatgccggc cgcaatcgcc gcaagagaaa 3351481 taagtgactg ctcataataa atcatcttgc gaagctgctg ctttgatgtg ccaaacagtg 3351541 tcagcagccc aaactctttc tttcttgcct gcaaaaacgc tgaattggaa tatgtgatga 3351601 aaaatataca aaacacaatg atgacgacaa gagctgcgct caagcatgtt ttgacaaggc 3351661 ttcctccata tatattgtct tcattgacat caggatgaaa aataaatgat gtgaagacaa 3351721 aaaacaccga aacggcaaac acacagctta aaaagtaggc cacataccgt tgcagattcc 3351781 caagaatgtt tttacgggcg atagttctca aattcatgaa aatcgcctcc caacacactc 3351841 aaggtatcca atatactttg ataaaacacc tgcctgtttg ttcctctgtg aatctctgaa 3351901 aagaaacgtc cgtctttaat aaaaacaatc cgtttacaga aacttgctgc tgtggcatca 3351961 tgcgtaacca acaaaatcgt cgcttccttt tcctcattca gctgagccag tgtgttcatc 3352021 acttgctttg ccgattttga gtcgaggttt cctgtcggtt catcggcaag aatgagcgcc 3352081 ggattgtgaa taatcgctct ggcacaagct gcccgctgct gctgtccgcc cgacacctca 3352141 tatgtgcggt gatcgagaat atgctttatt tgcagcgtat ccgccagttc atccaatcga 3352201 gcttccattt ctctcagctt taccttatcc aatgcgagcg gcaagagaat attttcacga 3352261 atcgtcagcg tatcaagcag attaaaatcc tgaaagacga agccgagttc tcttctgcga 3352321 aacaaagcca gctcttggtc ctttaacgtt ttcggctgaa tgccgttgat catcatctcg 3352381 ccctgggtcg gcttatcaat ggtagccagc aaattcaaaa gcgtggtttt tccgcttccc 3352441 gacggcccca taatcccgac aaattctcct tttgacacac tgagatcaaa ggcgctgagc 3352501 gcttggtatg atattgttcc tttatttgaa tagtatgttt tcgataggtt cgttgtttgc 3352561 aacacgttca tgttctgctc ctcctttttc tttattataa aaaggaagtc agcatcctcc 3352621 catcgaactt tcttgcaatt ccgctcccca atcttacaat gctgtcacat tcacgagggt 3352681 gtcacttgaa aacacgatgg tcatcacagt gccagcccct tcttttgatt ccgcatacag 3352741 cttatggccg agacggctgc acacctgttt tgctaaataa aggcccattc cagttgcctc 3352801 tttcatggtt cgtccgtttt ctccggtaaa aaacgcgtca aaaatccgcg gcagatcctg 3352861 cggcggtatg ccgattcctt cgtcggcaac cgacaagcgc gtctcatgtc cctgtgtttc 3352921 aatccggatt gtaatagggt ctcccacacc ttgctttgaa tattttaagg cgttgaaaag 3352981 gatttgctca acaacaaagg aaagccactt ttgatcactg gaaatctgaa cggcatttgg 3353041 cggcacatgt aatgttggaa aaaggcgccg cttgataaac tgacgttttt cctgattgat 3353101 cagtgaacga accatttctg ccaaatcaaa ggtttgcggc tttacatcaa atgcaaattc 3353161 ctccagccgg gccgtttgca gcatcatatc aagaccgtgg cgaaatctct cattctcatc 3353221 ctccagctcc tctaaaaacg tcggaaaaga ggatgaggtt ccgttttttc cttcctgaat 3353281 cattaaggat atgacagata ccggtgtttt catatggtgg acccattggt tggtgaaggt 3353341 gtaatgctgt ttttgctgat tgatatattg tgagagcctg ctttcgtatt gctgcccgag 3353401 tgcgttgatc atcttcgtcc aaagcgcttg ctctcctgtt cttggctttc tggctttcaa 3353461 agactgtccg atgtcattcg aagaagaggc ttgttctgca agctttttaa catatgtgag 3353521 aaaggaaaat tgccgaacat aatcagcagc aaaacctgcg gctaaaagag taccgggcaa 3353581 aatccatatg tacatcatat tttctttgga aggttctgcg ccgctctcta caatgcttaa 3353641 atacgcaatc agcatggcgg accctatccc taataatgaa aatagaataa tggctaagcg 3353701 gtcgatgaga taagtcttta acattccgct tcatccttcc gattgacttg aaattgataa 3353761 ccttgtcctc tgattgtgga aatgcaatct gtcagtcctg cattctccag ttttctccgc 3353821 agccgattga cattgaccgt taacgtattg tcatcgacaa aatcaacgtc atcccataac 3353881 gcctccaata gttcatcacg agagacaatt tttttatgct ccctcacaaa aatcgagaga 3353941 agctggaatt ctttttggga aaacaaaatc cggacgctgt tccattcggc ctcattctga 3354001 tcaggataaa tcgtcagccc gccaagctcc actattctag attcctgcgg caaagagggc 3354061 gaatattcac catatgtgcg gcgcaggacg cttttgattt tggccatcac tacctctaga 3354121 tggaacggct ttgtgatata atcatcgccg ccattttcaa tcgccattac ctgattcagc 3354181 tcatcggtcc gtgccgatat aaagataatc ggcgcattgg aaatggtacg gatttgcctg 3354241 caccaataaa acccgtcaaa aaaaggcagg ttgatatcaa gcagcacaag atcaggcttc 3354301 atttctgcaa attccaattt tatatcattc agctgttcag caattttcac ttcatatccg 3354361 tatttttgaa gatgaccgcc cagcaaagaa gcaatccgct catcatcttc cacaagcaaa 3354421 atccgataca cgttgatccc ccttatatgt acatcacgat gatttttcta gaagattcca 3354481 aaattattat agcatgtgcg gaatagtaaa tcggtctttt tctttttgtt atgatagaat 3354541 gataaaggta aaattttcat aataggcagg tgtcgtgatg aagaaaatca tgctgtttct 3354601 ggcaatgacg tcaattcttt cagcatgtca gcccaactat accgggaaat acatagaaat 3354661 tggggataca ctaactgact ataccaaaga gtgctttaaa gagaatgaaa ttccttataa 3354721 atacgaaaag ggaaaactgt atatcccaga agacgcattt gatacagcaa tctacacttg 3354781 ttcataagaa aaagcttgca gataacctgc aagcttttca cgttacaaaa aatgagtatt 3354841 taatttctct tcaaatcctg aagggccgat gtcgcttttt tgaatgttac cgccgttttc 3354901 ataaatcgta aaatggcgct ctgacatgac catccttccg ctcggcgtca gctttgaggc 3354961 aagcagggat ttgttaaaag gagatttttc atgagagtga atgatgtcct tcatgttatc 3355021 taaatcaccg agatcactct cttcaagggt aaaggcgtac ccaatttgcc agccttctcc 3355081 tttgtccatc agcagaacat agctgccctt ttctgtctct tcctttttga ttcggaatga 3355141 cccgactggt gactgtaccg tttctccgga aagcggtatc ggctggagcg ccaggttgat 3355201 gccgaagccg atatcaacga ggtaatcgcc gttttccgca gacagccata cagcagcatg 3355261 cgtcccttct agtgcccatc cctcttgatc gcctgcataa accgttcctc gaatgagctt 3355321 cacatgaaac ccggcctcac gcaagacaaa ataaaggaaa ccatttagat cgtagcatag 3355381 gccgccgtgc tgatctttga gcagacgtcg ccatagctct tcttttgtga tcttataatt 3355441 ctcttttgca agtacggcac ggttttcgaa tggaaaacgg tatgccattg ctttaagaaa 3355501 aaggggaaga tcgccgaagc tgacatggtc tttctcccag ccgattttct gaaagcagtc 3355561 ttttagaaag tcactcattt ttatcaccta aacttcttct tgaacgtaag cagccagctt 3355621 ctccagcgcc tcttgttcat cttctccctg ggcaatcaag gtaacctcag tgcctgtgct 3355681 taccgcaagg ctcatcagcc ccatgatgct tttggcgttt acttttttcc catccttctc 3355741 aagaaacaca tctgacgtaa accggtttgc ttcttgtaca aacaaagcag caggacgtgc 3355801 ttgcagtcct gtctttaatc gaacttccac tttctgttga accataagat ctcccctttt 3355861 ctttacggtt attttaaagt gacggtttgc cctgtccgca gctgttctgc gatttcgtca 3355921 agttttctca gcctgtgatt gatccctgat ttgctgattt tcccgcttgc taccatttcc 3355981 cctagctctt tcagcgtcac ttcctgataa tcaatccgca gctgcgcaat ttcccgaagt 3356041 ttttcaggca gcgcctccag gccgattctt tcatcgatgt atttaatatt ttccacctgt 3356101 ctcagcgatg cgccgatcgt tttgtttaag ttggctgttt cacaattgac gaggcggttg 3356161 accgaatttc tcatgtcccg aacgattctg acatcctcaa atcgcagaag cgaattgtga 3356221 gcgccaatta cgttcagaaa ctctgtaatc ttttcagcct cttttaaata ggtaatatag 3356281 ccttttttcc gttcaagcgt tttgctgttt aactgaaact catttaacag gtcacataat 3356341 gaatcgttat gctccttata aagagagaag atttctaaat gatacgagga ggtttccggg 3356401 ttattgaccg aacctcctgc caaaaatgct cctctcatat aagaacgctt gcagcatctc 3356461 tttttgacca gctctttcga aatacttcgt tcaaacacaa aattctcccc gagtattttt 3356521 aaatcctcta agatcgcttt tgcattttct gaaaaacgca caatatagac gttattcttt 3356581 ttcagccgca ttttctttct gaccagcagc tcgaccgaca catcatattg ttttttcagc 3356641 aatgtataga tgcggcgggc aatcgccgcg ttttcggttt gaacatcgag tacgagatgg 3356701 cggtttgtaa atgataaagc tccattcatc cgaatgagtg cagacagctc ggcattaatg 3356761 cagcagtcct tcacttccag attcgttaat tctttttttg tttctgatgc aaatgacata 3356821 tagccacctc atttcaaggc ttcattcttt cagtaaatca acaagaagag aggccacttt 3356881 atgtgtatcg tgacgtatta cgtcattttt atacgttaca atttgatctc tgatgacttc 3356941 aagccccatc gctttcagct cttcgatatc aaaatcaaca ggacgcgccg attccatttc 3357001 gtacttacgt tttatttcgt cgggaatgtc ttcactgttc actaatatcg tatcaataaa 3357061 accacagccc atatgctgat tgagcgcttt cacatgatca gcagcggtgt aatggagcgt 3357121 ttcgccgggc tgagtcatca cgttgcaaat gtatactttt ttcgccggcg cctttatcac 3357181 ttcttccccg atttttggga cgagcaaatt gggaagaatg ctggtataga ggcttcccgg 3357241 gccgataata atcaaatccg cttccctgat tacgtctatt gtttccggca gcggatcaat 3357301 ctgttcaggc gtgagaaaaa cacgcttaat gcgctgtccg tattctggga tcgttgactc 3357361 gcctgagacc acgcggccat cttccatctc agcatgcaaa acgacactgg cattggcagc 3357421 cggcaaaacc tttcctctta cattcagcac cttgctcatt tctgtgacag cgtgaaaaaa 3357481 atcaccggtt atatttgtca tcgctgccaa aatcaaattc ccgagagaat ggcctgttaa 3357541 gtcattccct ttattgaagc ggtgctgaaa aagatcttca acaagcggct ccacatcgga 3357601 taaagcggca agcacatttc tgatgtctcc gggaggcgga attttcagtt cattccgcag 3357661 acggccagag ctccccccat catcggcaac tgttacaatg gccgtgatgt caacgggttt 3357721 atgctttagg ccccgaagca atacagaaag acctgtaccg ccgccaaaga ttgcgatttt 3357781 cggcttttgt cccatcttat ttccggcttc tcttttcaat gtcccggtga gtaacatgag 3357841 tatagtaatc ctttttgaaa taatcagcta aattctcggc taatgtcaca gagcggtgct 3357901 ggccccctgt gcagccgatc gcaatgacaa cctggctttt tccttctctt ttgtaagatg 3357961 gaagcataaa gctcagcaga tcaattaatt tctcattgaa cttttgcgtt tcattccact 3358021 tcatgacgta agaggaaacc tctttatcct tgccagtcag cggccgcatg ctttcgatat 3358081 agtacggatt cggcaaaaat ctgacatcaa agacgagatc tgcatcaatt ggaataccgt 3358141 atttaaaacc aaatgacatc acatttacgg taaatgtctc tccttggttt gtcgcaaagt 3358201 gcttcacgat tttttcacgc aaatcacgcg gcttcatgtc agacgtatcg taaatgattt 3358261 gagagcggcc ttttaattcc tcaagcagct ctcgttctag cgcgatgcct tcaagcggca 3358321 ggccagtcgc tgccagcgga tgcgagcgtc tcgtttcttt atatcttgtg acgagaatgg 3358381 aatccttcgc gtccaggaat aaaattcgcg gtgtgatcca cggattttcg gccatttcat 3358441 ccagcgcttc aatcagccgg tcaaaaaatt cgcggccgcg caaatccatc acgagcgcaa 3358501 ctttgctcat tttcgaattt gattccttca tcagctctaa aaacttcgga agcaatgaag 3358561 gcggaagatt atcgacgcag aaatagccga gatcttcaaa gctttggatc gcgacagttt 3358621 tccccgctcc cgacattcca gttataatga caagctgaat atcatgtgat tcactaacac 3358681 tcatctttct cccccctgac ttgtctttct atttgatgtg ctgcgggtct aaacgataac 3358741 tgagcagctc aaattccggt gtatacgtaa atgtgccgtg cagcagccct tgtcccttca 3358801 tcataaaatc aaggatatgg ccgtctccag gggccatagg caggttctga atgtcattga 3358861 catcgtgcca ctgcagtttg ccttcctctg attctgatac attttgtcct gtatatgaat 3358921 cagcgacaaa cgtaaacatc atccactcgg agacaatgtg gtcaccgtct ttaataataa 3358981 aggtaaaaac gccttttaat tgaggattta tgatatagat accagtctct tctctgtact 3359041 ctctgatgac ggagtctctg actgattctc cgctctccat cttgcctccc ggcgcgaccc 3359101 accatccgcg tctcggcttt tgaagcagaa gaactttgtc atccgtctga agcacacaat 3359161 ttgtcactct ttgcaagtac gtcacctaac cttcgtcctg tcatcgtctc tttattatac 3359221 cgcttcaaga tgcctcccac aatgaagaga cattgacaat cttttcttct attttacagc 3359281 atattcattc cttaattcag atgattttgc tgtaactgga attctctttt atttatggac 3359341 aaaaaaagga cacggataac tggagaatcc gtgccaaaaa agtgtattca ttataaaaag 3359401 ggggtcaatt actttattaa tcataaccga aaagcattac acatgtgtta cagcggaatt 3359461 aaaacccagt aacgtaatgt gaaactcgta tgacagccct ttttatttta aggttttcag 3359521 cgtttcttgg agctcttcga cataatgttg tacgctttgt gccgcaatgc ttccgtctcc 3359581 tgtagccgtt acgatttggc gcagtgattt ttcgcggatg tctccggcag cgaaaatccc 3359641 ttcaacctta gtttccatgc ggtcgtttgt ttcgatatag ccttcttcat tcgtaatgcc 3359701 caggttttca aacggtttag acagaggaag catgccgatg taaatgaata cgccgtctgt 3359761 tttgaattca ctttcttcac cggttaccgt atcgacaagc gttacgttac cgactttgcc 3359821 gttttcctca tgaatttcct tcacagtttt gttccatagg aagtcaactt tttcattatc 3359881 aaatgctctc gcttgaagaa tactttgagc acggagttta tcacgtctgt gaacaatcgt 3359941 tacttttgaa gcgaaacgag tcagatatac gccttcttca accgcggaat ctccgccgcc 3360001 aacaacgaca agttctttgc ctttaaagaa agcgccgtca catactgcac aataagatac 3360061 accgcgtccg cccaattctt tttcgccagg cacgccgatt tttttatatt ccgcacctgc 3360121 agcaatgatg acagcacggg ctttatattc ctttgaacca gctttgacta ctttgtactc 3360181 tttgccgtca atgacctctt taatatcgcc ataagcgtat tcagcgccga attttttcgc 3360241 gtgttcaaac attttgttag aaagctcagg cccaaggata ctttcgaatc caggatagtt 3360301 ttctacatct tccgtattgg ccatttgtcc gccaggaatt cctctttcaa tcattaatgt 3360361 cgataaattc gctcttgatg tgtatacagc ggccgtcatc ccagcagggc ccgcgccgat 3360421 tataatcacg tcataaattt tttcttctga cacactattc actccttaaa ccatcttttc 3360481 aagtttgggc tctttcttat aagataagaa tccccatcaa acgtattcct tacccatatc 3360541 ctataaaatc tcatggtgat acgctatttt tttgctcaac acgattaaat gtattcgaaa 3360601 agggtatatg ttaataaaga aagagccttc tgtttataga aggcccttgt catatttatt 3360661 attgaacaac acgtcttaca acacctttaa atgctgcttt ccagtaagga ttgctcatag 3360721 agtcaacaga tacgccatga gatgtattgt cgtttaggaa agtaccgttt cctaagtaga 3360781 ttcctacgtg tccatttgtt ttgtaagtgt caaagaacac aaggtctccg cgtttcattt 3360841 cagacgcgct gacagcttgt cctctgccaa ctaacgtatc agttgttgtt ccgcctacag 3360901 gtccaaggtt aacacctgca gaagcgtatg cccagcgtac gaatgatgag cagtcaaaaa 3360961 tacggttgtt gatatcagac tgagtgcgtc cgccgccaaa cttgtacgga gattgtccta 3361021 caatgcttga accaacgctg atcgcgcctt caattccgcc agagttgctg ataacagtgc 3361081 cgcctgaatt gctgtttgag ccgctgctct tcttagaaga tgagccgttt gacgaactgt 3361141 ttgatgaacc gttagaagaa ttgtctgaag aattgtctga agaatcatca gatgagcttg 3361201 cttttgatga ttcagttgtc gccgtttgac tgtcatctgt ttgtgtttca tcagatgctt 3361261 tttgtgcttc ttcctgcttt ttgatcaaag cagccgctgc ttcttgttct tttttgatgc 3361321 gtgcttgttc agcttcagta tttgcttttt gatttgcaag ttcagacgcc tctgatttta 3361381 attcagaaat cgctttagcc gttttctttt ggcttgcttt tgcttcgtcg aaaagcttgt 3361441 ctttttcatt aagctgttta tcaaggtctt tttgcattgt ttctaattta gccaaggcag 3361501 cttgaacttc tttcagcttg tcattcaaat ccgcttcaga atcttcgagc ttcgctttat 3361561 cctgctcttg ctgtttgatt aaatctttgt ctgcgtccac aatagatgaa accgcagtcg 3361621 cacgagagat aaagtcacca aagcttgttg atcctaaaag aacatctatg tatccttgag 3361681 atccgccgct ttcctgtaaa gaacgaacgc gttttttcag gatttcattg cgtttttcga 3361741 tgcgtgcttc agtttcttta atctcttttt tcagtttttt gatttcttct tttgttttat 3361801 cgttttcttc ttttttatct tcaatcttgt tgcttgtatc aagcgcctta tcgttaatgt 3361861 ctttcagttc tttttcaatc tttgattgat tttcctgaag ctcggttaat tctttttcct 3361921 tcgcttcaat gctggaagca acctcagatt gcttgctttc gattttttgt ttcttttcat 3361981 ctaatgtttc cgccgatgca gttttacttg taaatgggat caaaaaactg cttgtcccga 3362041 tgacggaagc caaaccaagt gtaattaaac tctttctcac tttttatatc ctccctttta 3362101 ctgtgaacct gtcctcattt ggaatcgtat tttgaacatc aagtttcgtt cctcatactc 3362161 tacgaggaat gatggttgtt tatggttaat tattctgtgc atctcttatt ctggttgtat 3362221 agcgtttatt tcacatcata tgtaaaaaac actaattcct tatgtacgag aatcattata 3362281 ccatcaagtt tcgacaaatt agcgataaat tttattacat ttatgtttca aacagatgtc 3362341 aagtcacaca tcatttgtca tttttcttaa gcgtgtaaaa aaactgtcga tattattttc 3362401 ttaatataat ctatctaaca aaaaaagagt cgattaaata aatcaactct ttaaaattta 3362461 ctattctaga atatcatcaa tatatttcat atatttcgtc aaagttgccg gagagatgcc 3362521 gaatcgggcc gctgtgtctt ttttcgtgtc ttgcttgcca tgggcttctt tccaaatata 3362581 acagatggct gctgcccagc ctttctcatt cttcaacgga gcagctgcac gaatttgctg 3362641 gatgacatga aaaacccagc agctcatgac ttctgttttc atctcttctt tttcagcttg 3362701 ctctaatagt ttgaccgttt gataagcgaa aagtgcatcc tctgaaacgt cagcagccgc 3362761 agaatctcca ttcagaagca gctttacaaa atgagtttca aaaggagcgg taattctctt 3362821 tgagcgtatc accgcttcaa gatgctctgt ttctcccttt gtgctgctga tataataggc 3362881 tgcgagtcgc tgctccacag atgaaggaag agcttccctc cgctcaatcc aaggcgccgg 3362941 gcggtcttcg ccgggatatt gcgactcgac ttttctccag atcgtctcgg caaagtcggt 3363001 atgtcccgta aaataagcag agcaggaaag ccagtaaaag aaggtgtcgt caccctcaaa 3363061 gccggtttta tataatgatt tgagccattt atatccgatc tcgtagcggc cgacaagcgc 3363121 caaagtagca cccaatttat aacgctgctc caatagcatc ggatagacat tggagagctg 3363181 atcactcaat tccgccactt tttcgtcttc tctttcataa tagtagaaaa cgagaagatt 3363241 gcataaggcg tgaagatttc cttcattatg agaaagcact tcataagcgg tttgcttcgc 3363301 ttttacaacg tttcctgaat agaaataggc aagcgcgaga ttgttgtatg ctgaccaaag 3363361 ctccggatat tcagttgtga tttcctcaag cgccgcaacc gcttcagcaa gctggccgct 3363421 ttccagcaat gactttgccc gatcctgttt caccagcagt tcatcctgat catacaacga 3363481 atcctcaatg ccgtcgtctc ctaaatcgag caaatcaagc agactatcgt tttcttcggc 3363541 gaattcacca tccgggtccg catcagaata agcggccgct tctttataag cttcctggaa 3363601 gagccccaga tgggcaaagt tattcgcttt aaagtaatgg cactccggca tttcggcctc 3363661 cagatttgcc atgatatagt caagaagatc gttcgactct tgatactggc ccatttccga 3363721 ataaatgacc gcaagctgtg aaagcatctc tgaatcctcc ggctccaaat gaaccgcgcg 3363781 ctgaatcagt ttgcttgccc gttttagatt gcgctcttta tacgctttca agcctttatg 3363841 aaaaaaatat tgtccatctt gaagcagctg gacaatttgt gcgtgatttt tatgttcaga 3363901 agtgtgtttt cccacaacta ccctccgttt tatacaatat taccgtcagt agtataccat 3363961 aaatcgtaag cccctcaata gttcaaaagg aaggattggg aaaatccctc ctctttttta 3364021 ttggctgatt cgaccaaaat ttacccggct ttgttttcta agtccgcatt cattttcagc 3364081 tgctgttcag caaaatcccg gtaaaggcca tgggaagcca ttaactcatg gtgtgttcca 3364141 cgaccggtaa tttccccttt ttcaacaaac aaaagctggt ccgcatctac aacggtagat 3364201 aggcggtgag cgataacaat cgttgtgcgg ccctccatca gcacctccag cgcctgctga 3364261 actgattttt cagattggct gtcgagactt gaggtagctt catcgagcat aagaatgctt 3364321 gggttacgga gaagcgctct cgcaatcgcg attctttgcc tttgtccgcc tgacagcata 3364381 atgccgcgtt cgcccacttc tgtatcaaac tgattcggca gctcctttat aaaattgagc 3364441 gcatatgcca tctccgcggc tttttcgatc tcagcatccg tcacatctcg ttctaacccg 3364501 tagcaaatat tttctctgat tgtcccggac attaacgggc tttcctgtga tacatacccg 3364561 atatgctccc tccacgattc aagcgagtaa gtatcgaccg gctcgtcccc cagccgaatg 3364621 gtccctgcag tcggagaata aaagcgttca agcagcttaa acagcgtcgt ttttcccccg 3364681 ccgctcggac cgacgatcgc tgtcactttc cctgcttcaa tgacggcgct gacctctttt 3364741 aagatcagct gatcaggctt atatccaaaa gacacgcgat caagctggat aggcagatgt 3364801 gcattttcaa tttgttttcc tgtcactgta tcttcctctt cctctgccaa aatctcaatc 3364861 attcgttctg ttgcaccgat tgatttttgc agctgtgtga aaaacgttgt aatctggccc 3364921 atcggcataa taatttgaaa caaatataaa ataaaagcca cgagcgctcc ggctgtgagc 3364981 tcgcctgatg agacctgcat gccgccatat ccgatcactg cgacaagcgc tgccattaac 3365041 acgagtgaaa taagcgggcc gacaagcgat tgaaccttgg cttcacgaac gccaagctta 3365101 aataatgagg aaatccccat cttcccgcgc ccatattcga catcctccgc atttgaagcc 3365161 ttaacaagtc tgatttccgg gagaatttga ttaagcaggc ctgtaaaacg agccgtttca 3365221 tcttgcgttt cccgtgaaat ggagaacatt ttccgtccaa tcggcaccaa aataagagcg 3365281 gccagcggaa cgaccactaa cacaagcagt gtcagcttcc agttcataat aaacaagatt 3365341 gtcaatgatc caatgacaga aatgatgcct gtaataaatc cgctgatatg ggttgtaatc 3365401 aattctttga ccaccatcgt atcgttcgtt acacggctga ctgtttctcc ggaagcattt 3365461 gtatcgaaat aagagacagg cagcttaatt aatttcttcc ataataactc ccgcagcccg 3365521 gaaatgattt tttgtccatt atagttaagc gcataggtgg cataagcgct taaacccgcc 3365581 tgaacgaaaa acaccagcgc gatcaaaccg atttgcgtgc ctgacagatt tgacatagaa 3365641 aaaccatcga caagctgctt cgttaataat ggaatgagca ggctgaccag cgtggttact 3365701 acactgaggg caagcgcaaa ggcgagcttt ccataagaag gattggtccg tcttactaag 3365761 gcaaaaaagg gtttcaattt acttttagat ttttgtttct tggttggcat atattttcct 3365821 cctgtttcag cgttcagaaa ggtgaaaagt catagcaaaa ggatgatttt tactctttct 3365881 caatcatatc aatggagaaa gactttttca gtatattttt gccgtgatca aaataaaaat 3365941 ctcccactca ttgtttgaat aggagatttt tgtgttagac atctttcact ggcttctttt 3366001 ttctgtaagt caatgttaca tcctgctgtc gcaggtcttc tattatcatt ttgtaccgat 3366061 caacttttgc ggtatgttct tcttttatca tctgaagggc agcttttcgt ttttcgctat 3366121 tagactcaag ctcttttttt atttttttta caatcaaccc tttttgccct ttgatttcct 3366181 cttttaatga agactcaaat ttctttgtca ggctgagaaa gtcgttgatc ggttgattga 3366241 gggtgcccgc tttccccttc atttcatctt gggtaagaaa catataggtc gttgatacaa 3366301 tttctgtttc actttctgaa aataaggaag tcactcttca tattcctcct aagactgaaa 3366361 atcaaataac tgagaaatca tttcttcttt ttcaaacagc ttttcaatac tctcgcggat 3366421 atttttgata aaatctcttt tttctgttgt ctgttttttt aattcagcaa caattccatc 3366481 atttgcagga agcgcacctg tgtggaatga ttcatgaact gagattttct ccaatttatc 3366541 gaatgtgtgg ctgaaaccag ctgcaagccg gaattgaaga tcgaaggcat aatgcgaagg 3366601 gttttcttcc atatgatgaa tagccgtgat gatcgcctgc tttttgtcta tgaagtcttc 3366661 atcgatttcc tgactgtaaa ccttctggta cttagaaatc gcatcttcca tatcttcaac 3366721 gattttcata ccgttttgat agattctgac agcggatgag agattgactt gaatcgtttc 3366781 tcccgagcca ctcttccctg taaaataaat atcggagcct ttatagctga agcctttttc 3366841 ctttgacaag gcgttgagca tttgaacgat gctgtggccg tcgacgataa gttttagtgc 3366901 gtcttttgtt tctgtgtcga gtgttttcaa tgaggacaga attgatttta catagtccac 3366961 tatttcacca acgtctttta aagcttgcat aaattggcca tgttttagat ggtctatgaa 3367021 atgttcgtac cgtgactcta tgcctcgcat actcgcatta atattcgtta attctttttt 3367081 gatgactttc ttttgcgttt catcaatata accattttca gctaactgat ctacgaccgg 3367141 tccgctgttt ctcaacaagg tatgaagaaa acctaaaaac gacggcagtt cctcttttat 3367201 tcggccatac atttgcttaa catcatcaaa atgctcatat aggacactta ctttctttaa 3367261 agcgccgtct gtgtttttca ctttttcaat caggtctatg tctatcccgc tggctgcctt 3367321 tataaaaccg ttcaagccgt ctttttcata gtcatcctta tatttttgaa ggaatttttg 3367381 aattgacctc acatcttcgt caggaacccc atccataatg tttcggatgc cttttacact 3367441 tgtatttgta tctgccatct tcacatcacc gaatgtaata aaatcggcct tgccgctgac 3367501 tccatacagc gggtcatctt ttgagatgcg ctgagtgatg tttgttgtta cgcctttgtc 3367561 ttcataatat ttttggattt ctttttttaa cttttctggc gggatggaat ctatatcttc 3367621 atatttataa ctaaatttcc taataacata tctatataaa ctttcatcag tttcaagtaa 3367681 ttgatcaata ttgacttgag ctccatttac cccataaact tcatcatatt ctccatcaat 3367741 caattgcacc ataacttggt tattatttgc aagtgaatgt cctaaggcga atgtttttaa 3367801 atcctcagag ttacctgctg ctttctttgc tttgttagta aactcctttg tagcctcata 3367861 ctgactatga tcaattccta aaaaaagacc aaaaaagtta tatgaccaat ccttattatc 3367921 ggcactacct tctgaaataa tctgaagctg atcaatatgt tttttctcat ctattatatg 3367981 gattgccgtt ccatcgtaac ctgattctct ggtcgaactt tgtatacttg tattctgatt 3368041 tacaagttca ttggaggtgt aaatttcaat tttcatattc tcaggaagat cgtggtgggt 3368101 ttcctcttta taaattctgc gtatatctgc ttcgaaatcc ttcttagctt tcttaacttc 3368161 actcgcaata gttgaggcaa acttttgttt atagtcatat tctaaatcaa ttaaccttaa 3368221 ctttacgttc tcattctcaa atacattttt atttcccatc ttatttctcc tttttatcta 3368281 ttaaaaaggt gatagaatta attaatttct caactttatt tttagccttt tcttcatcta 3368341 aggagcatgg ttgattttca tttttgcatc caagggtaaa ggcgtattct actcctaggt 3368401 tatcttcctc tgtagactta acatatccaa aataactgta tgaataatta tattttctat 3368461 caatatcgtc aaagatgtct tttttcttgg cagtgtaaat atccgttttc tttttgctgc 3368521 tttttttgta ttcgccttta taatcatttt ttccactaac aatatctagc attgtcttag 3368581 gttcattcgc aaaactttct tctttgtaat atgttacatg gccatcaaac attacattgg 3368641 tgtctttatc ataactatta aatccaatac tttctttgtt tttcccggtt aacgatgatc 3368701 ttcttgatag atactttcca tcctccggaa acaacatcct aaaccctttc agcttagatt 3368761 ccagcaaata atatcctggt tcctcttctt ttgttgacac catgtactct ctcgttttct 3368821 cgtcctgaaa cgcaggtact tgaggcagat ccttgggatc catgtctttt ggttttaccg 3368881 cttctgtttt attgtcattt gtgctgtttt tatcattgtc attcatactg catcctcctg 3368941 tcagggcaag taataagctg aagcaaataa agatgatctt tttcattacg aacctccacg 3369001 ggttttgtga gaatagtatt ctatttttat atcaaaaata attctattga cctggttaag 3369061 agatgattat ttcatccttt ttcatgttac atcatggcgg aatttggata aataggaaat 3369121 gagactcggt tttgatctcc ttttattaac taatcatata taacacccaa tataaatcta 3369181 aatacctatt acttttttca caaaacaaaa agagccgtat catccggctc tttactcttc 3369241 aatctcagaa tggcgttttt tcaatacgtc aagcacatca tccagcggca gggattgttc 3369301 tctgagcagg acaagcaggt gatacagcag gtctgccgct tcccatttga gttcctcatg 3369361 atcccggttt ttcgcggcga tgatgacttc ggatgcttct tctccgactt ttttcaaaat 3369421 cttatcgacg ccttcacgga agaggtacgt ggtgtaagct ccttcaggca tttccgcttg 3369481 gcgttccgcg atcacccgct ccagttcgtt catgatgccg aatcggtccg cggcctgttc 3369541 ttctgtttgt tcctttgtaa aacagctgta gctgccagtg tggcatgccg ggcctgacgg 3369601 ttctacgagt acgagcagcg cgtcttgatc gcagtcatac cggatacctt tgacggcttg 3369661 cgtgttccct gaggtttctc ctttatgcca taacgcttgg cgtgagcggc tgtaaaacca 3369721 tgtttccttc gtttccagcg ttttttcgta cgattccttg ttcatatacg caagtgtcag 3369781 cacttctttg cttgccgcat cctgcacgat agcaggaatt aatccgtcct cgttaaaacg 3369841 cagttcatct gcctgtttca tctcacattc accccgtact ctttcaagta tgatttcact 3369901 tctttaatcg atgtttcttt ataatgaaaa attgaggcgg ccagcgcggc gtcggcttct 3369961 ccttttgtaa aagcctcaag catatgctgt gcgtttcccg cgcctcccga agcgataaca 3370021 gggacgggga cagcttcgga aacaagcttt gtcagcgtgt ggtcgaaacc ttttttctca 3370081 ccgtcggagt ccatgcttgt cagcaatatt tctcctgccc cgcgtttgac gccttctttt 3370141 gcccacgcgg tgacctccca atctgttttc tttctgccgc cgtgcgtgta gaccttatat 3370201 gtgtcagatt ctttgtcata cttggcatca atggcaagta cgatgcattg agaaccgaaa 3370261 aactcggctc cttctgtaat cagctcaggg cggagaacag ctgccgtgtt caccgacact 3370321 ttgtccgctc cggcacgcag tatcgttttc atatcgctga gctgattgat gccgccgccg 3370381 actgtaaacg gaatggcaag cttcgcggca acctgctcca caacgtcaac catcgtcttt 3370441 cgtccttcgt gcgaggcgga gatatcaaga aaaacaagtt catccgcacc ttcccggtcg 3370501 tacacttcgg cgagttcaac tgggtcaccg gcatccttca attcgagaaa ttgaattcct 3370561 ttgacaacgc gtccttcttt gacatcaagg catgggataa tccgttttgt gatcatttgc 3370621 gcttcaccct ttcaagcgcc tcactcagcg taaactgatt ggtatacagc gcttttccga 3370681 tgatcgctcc agagacgccg tccgcctcat tgcgggcgag agcttcgaga tccgcgacgg 3370741 agctgactcc gccggaagcg atcaccgatt tccccgtttc cttagcaagc tcgaccgtgc 3370801 ttttaacatt ggggcctgac agcattccat ctgtcgcgat gtcagtaaaa ataaagactt 3370861 ccgcaccttc attggctagc tctttgccca gttcagttgc cttaagggtt gatgtttcaa 3370921 gccatccctc tgttgaaaca aaaccgtttc tcgcatccag tccgattgca attttctcgc 3370981 catattgttt cagcattttt ttgacaaacg gagggttaga aactgctgag cttcccagga 3371041 tcacccgctc gactcctgct gataaatatt catagacgtc attttcagaa cggatcccac 3371101 cgccgatttc gactttcagg ttcagctttt gcgcaatctc aatcacatgg cggtcattca 3371161 ctcttttccc ttctttggcc ccgtcgagat caacgagatg gatccattcg gcaccctctt 3371221 tctcaaataa ctcagccatg tcgtacggtg aatcgccata tatcgtttcc ttattataat 3371281 ccccttgaac aaggcgaaca catttgccgt ttctcatatc aattgccgga tataatgtaa 3371341 aagcactcat tttttcacct tctgttctgc tgccattttc gtaaattggg ttaaaataga 3371401 cattccgacc gtgctgcttt tttccggatg aaattgggcg ccgaagacgt ttctttttcc 3371461 gactacagca ggcactcgta caccataatc ggcgcttgcc agaagcgcgt tctcctccat 3371521 cccgtcaatg taataggaat gaacgaagta agcgtagcct tgttctgttt tagtcagcag 3371581 cggagattca ttatgaaaag aaagacgatt ccagcccata tgcggaacct tcagcttgtt 3371641 tcctttttca tcttctgctt tcagcctgac tgcttttcct tttaacagcc cgagtcctga 3371701 agcggtgccg ttttcttcgc tttcttcaaa taaaagctgc atgccgaggc agatcccgag 3371761 aagcagcctt ccctctgaga ccatatcgtg aatcaattga tcaagcttcg tgtagcccaa 3371821 attgtccatc gcgtctccaa atgaaccgac tcccggcaaa atgaaagcat cagcttcttt 3371881 cagctcctcc ggcttttcag aaacaaaata cggcacgccg acacgttcaa gcgcctttga 3371941 gacactgtat aaattcccca ttccgtaatc tatcacgccg atcatttaca gcatcccttt 3372001 cgttgacggt attcctttaa ctcgcggatc gatcgttgtc gcttcatcaa gcgcacgtcc 3372061 cagtgcttta aaaacggctt caatcatgtg gtgggtattt gttccataat gaacgatgac 3372121 gtgcaggttc attcgagctt cgagcgccag cttccacaaa aattcatgta caagctccgt 3372181 atcgaaagtt ccgactttag cagccgggaa atcagcgcgc atttctaagt gcggccggtt 3372241 gcttaaatca atcacaactt gagcaagtgc ctcatccatc ggcacaaacg ccgatccgta 3372301 gcgtttgatt ccttttttat cgcccaacgc ttcgagcagc gcctgcccta agcagatgcc 3372361 gatatcttca gtcgtgtggt gatcatctat atcaacatcg ccttttgcgt taatggaaag 3372421 atcaaattgg ccgtgtttcg tgaataaatc caacatatgt gtcataaacg gcacatctgt 3372481 tttaatatcc gcttgtcctc cgccgtctat tgtaaatgcc agctcaatat ctgtttcgtt 3372541 tgttttcctg acgcgttccg cttttctcat ttagaaatcc tccgttctct cgcttcaatt 3372601 gatctggcat gggcttctaa cccttccagt ctggcaaaag ccgcgatgct ttcggcatgt 3372661 tcttcaaagg ctgattgact gtaagaaata atgctcgatt tcttttgaaa atcagttacg 3372721 tttaatggac ttgaaaatct ggctgttccg tttgtcggaa gcacatggtt cggtccggca 3372781 aaataatcac cgacaggctc agggctgtat ctgcctaaga aaattgcacc cgcatgtttg 3372841 atactgccaa gcaaagcttc cggagactgt gttatgattt ctaaatgctc tggcgcgagt 3372901 gtattgacag tctcaatcgc ttctaccatt gtttccgcca catatataca accgtaatct 3372961 ctcactgaag cttccgctat ttctcttcgc ggcaaggttt ccagctgctt attcacctcg 3373021 gctgaaaccg tctcggccag cgccatggaa tctgtgacaa acacacatga gctaagctta 3373081 tcgtgttccg cctgtgacag cagatcggct gcaatttcgc tcggaatcgc tgtttcatca 3373141 gccagcacga cgatttcact cggtccggca atcatatcga tatcgacatc gccgaacact 3373201 tctcgtttgg caagcgcgac ataaatgttg cccggacccg tgattttatc caccggctca 3373261 atggtttctg ttccgtatgc taacgccgca atcgcctgag cgccgcccat tttgtaaatg 3373321 tcttttatgc ccagctcggc tgcagcaacc aaaactccag gagacagcag accgtctttt 3373381 cccggaggcg tgacgagaac gattctttca acgcccgcta cgagcgccgg aatcacattc 3373441 atcaaaacag atgaaggata tgcggccgtt ccccccggca catatacacc ggcggaatcc 3373501 agcgccgtca ctttctgccc cagcattgtg ccgtcctttc tgtgataaaa ccaggaggat 3373561 tgcagctgtc tttcgtgata ttccctaata ttttcgattg cctgcctaat cacctgaaga 3373621 agacgtgaat ccagtgaggt gtatgcctcc tcaaattctt cttttgtgac cagcgggctg 3373681 tctatttcga tgcagtcaaa tttcgccgtg tagctgcgaa ccgcctgatc accgtttgct 3373741 ttaacatctt caataatgga ccggaccgtc tttctttgct cttccgttcc ggcatcgatg 3373801 gaacgcttga gagaaagccg ttccgctccg ctgatggttt tgatcttcat tttgccgtct 3373861 ctccttccac aacgagagat aggcgggatg ccatttcgtc aatcacatcg tctttcatgc 3373921 gatagcttac cgggttgaca ataaagcgag aggtaatgtc acaaatgtgc tccgtttcaa 3373981 caagcccatt ttctttcagc gtctgtcctg tggaaacaat gtccactatc cgatctgcaa 3374041 gcccaatgag cggagccagt tcaattgaac cgttgagctt aataatctcg acttgttctc 3374101 cctgctctct gaaataactg gaagccacat tcggatactt tgtcgcgatt cttggcgcta 3374161 ctccgctcca gtctgtattc ggaagtccgg cgacagctaa gtggcatttg ctgatgttta 3374221 aatccagtac ctcatacaca tcgcgttcct cctccagcat gacatccttg cccgcaattc 3374281 cgacgtctgc cacgccatgc tccacatacg tggttacgtc catcggcttc gctaatataa 3374341 accgaagatt ttcctccggc acatcgatga tcagttttct cgaatcttca aactcctcag 3374401 ggagcctgta gcctgcctgc ctcagcagcc ctgccgcttc ttcaaatatc cggccctttg 3374461 gcatcgccat tgtgagtaac ttacccattt tgctcttcct ttctggcacc gataaaataa 3374521 gtgacgtttg caaaagattt tgtcatctgg tcgatatttt ctattcccga taaatcttga 3374581 agaaccactt tgttcccttt catgcgttct tcattcgcat aagcgatggc ttgcgcccgc 3374641 tgctctttgc tgaaaataac agcgtctatt tcacaaggtt cgtccttcat atgaagggct 3374701 tcaatcagcc ggtcgatccg aagcccgaag cctgttgccg gtgcaggtga atcaaaatgg 3374761 cccagcagct tgttgtaacg gccgccgctt ccaatgacaa aaccgacatt ctcggcgtac 3374821 acttcaaata aaatccctgt gtaatagctc atgtggctga ccatattcag atccaggcgg 3374881 acattttccg tacatccgta atcctcaaga atgtcccaca gcgccttcag ctcatcaacc 3374941 acgctttttc cttgcgcaga atcgacgatt tcctcggcac gtccgcatac ttctataccg 3375001 ccccgcagtt caaggagctc aagcagcctg cttttatcaa tggaggaaag cgggagagac 3375061 ttgacatgct ctctgtagcc gacgtagttc ttttcatata agaacctccg cagcacatca 3375121 gctcgttcaa cgtttccgag cacctcaaca aacaaagcat ccgcaatgcc ggcatggcca 3375181 attgcaattt taaaggatgc cagcccagcg ttttttaatg ccccgacgac taaagcaatg 3375241 acctccgcat ccgcgctcgt cgtgccgtca ccgattaact ccactccgac ctgctcgaac 3375301 tcagccggac gtccgccttc acgctcctga gccctgaata catttgccgc atagccgact 3375361 cttagcggat gaccgtgttt cagaagcttc gatgccgcca cccttgcaat cggccccgtc 3375421 atatccgggc gaagcaccaa tgtcttgccg tcctgatcaa gtagcttaaa cagctgctgc 3375481 tcttcaattg ctgactggac gccaacggta tcgtaaaact ccagtgtcgg cgtttccata 3375541 aattgatatc cccatttatc aatcaaatcg gttaacgatc gtctcacctt ttttttcgtt 3375601 tcgtataaac cgggcagtgt atctctcatg ccgtgcggtt tttcaaacat aaacatcaac 3375661 ccgagcacct ccgctgttat cttatgaagg aaaattccga atcctttagt tcgctaatat 3375721 gataatatgt tagcagatga aagaatgaaa atcaacgctt aacttcagta aggatatttt 3375781 tagttcaaat atccttctcc tcattatgaa aaaatcatga ataatgtatt aaaggtacgt 3375841 aatatctcaa attctttatg tttggcatgc tataatacaa atcaaataga gaacaaggag 3375901 ataaagatga aaacactgcg aactctatgt gtcctgatga ttctttcagg cgttattttt 3375961 ttcggactta aaatagatgc aaaagatata gatattcctt ttttgaacag ccttaaaaaa 3376021 gtggtttctg atagcgatac agactcagct gcgaatagca aaaaggagct gaagggaagc 3376081 gcaaaaccgc tggatgtcat cctttacaat caaatggacg caccccggct ctataacggc 3376141 tgtgaagtaa caagccttgc gatggtgctg aattatgcgg gatacgacgt gacaaaaaat 3376201 accctggcaa atcaggttgc cacagtgcct ttgacataca gcagcggatt aaagggtgat 3376261 ccgaatgacg gatttgtcgg ggatatggcg aatggccctg gtctcggtgt ctaccatcga 3376321 ccgatctatc agctggcgaa aacctatgcg ggagacaaag tgtctgatct gactggaaaa 3376381 agtatttccg ctgtttatca gcagcttgaa aaaggcaatc cagtttgggt tattacgaca 3376441 gccaacttta cgccagttga caacatgcag acatggaaaa cgccaaacgg aacgatagaa 3376501 attacgtaca gcgaacacag cgtcgccgtt acgggatatg atgataaata tgtgtatctc 3376561 aatgatccgt atggctataa aaacagaaaa accgatagaa caagctttga aaaagcgtgg 3376621 aaacaaatgg gcagccaggc cgtggttatt caaaagtaaa cacctgaagc ctcactatgc 3376681 tctattctga gcaaatacga caatattcat gctttttgta tcaatcggta agatcgattc 3376741 attttccatt tttcacccaa aattgtcttt actttcaggc tgtctgtttt tatgattaaa 3376801 gcagattcag ccttgccccg atctatgcga gagaagccgg tgcaagtcgc tgacgcttct 3376861 cttgcaaaaa atgaaagata tccggggagg atttatcatt gaaaaaaatc gtgtctatcc 3376921 tatttatgtt cggtttggtt atgggtttca gccagtttca gccatcaacc gtttttgcag 3376981 ctgacaaagt ggtgcacgaa acaattatcg taccaaaaaa tacaacatat gacgggaaag 3377041 gacagcggtt tgtggcaggg aaagaattag gtgacggaag ccagtcagaa aaccaagacc 3377101 ctgtttttcg tgtggaggat ggagcaaccc tgaaaaatgt ggtgcttggt gcacctgcag 3377161 ctgatggcgt gcacacttat ggaaacgtta acattcagaa tgtgaaatgg gaagatgttg 3377221 gtgaggatgc gttaacggtg aagaaggaag gaaaagtgac gatcgacggc ggttctgctc 3377281 aaaaagcgtc agataagata ttccaaatca ataaagccag taccttcaca gtgaaaaatt 3377341 tcacggcgga taatggcggg aagttcatta gacagcttgg tggttcaacc ttccacgttg 3377401 atgtgatcat cgacaagtgc accatcacaa acatgaagga agcgatattc cggacggaca 3377461 gcaaaacaag cacggtcaga atgacaaata cacgctactc taatgtcggt caaaaatgga 3377521 ttggtgttca gcatatttac gaaaacaaca acactcaatt ttaacaaaaa aagtccgctg 3377581 atgttattca gcggactttt tcaatctttc ttgcatttct tccttcgtat agatgatcct 3377641 catcggattt ccgccgacaa atgccccgtc aggcacatcc ttatggacaa gcgttccggc 3377701 ggacacaact gcgccatctc ctattttcac cccgggcaga atggtcgtgt tggcaccaat 3377761 catcacttcg tccccgatca gaactttgcc gatccggtat tcgtgaatca aatactcatg 3377821 ggccagaatg gtcgtattgt acccgatgat tgtatttgtt ccgactgaga tcttttccgg 3377881 aaacatgata tctggcatca ccatgagggc aaaggatgtc tgttttccaa ccttcatccg 3377941 cagaaatgtg cggtacagcc agtttttcat ccctataaac ggcgtatatc tcgcaatttg 3378001 aatgacaatg aaatttttga cgacctttaa aaaaggtacc gtttgataga catgccacag 3378061 tgagttggcc cccgagaccg gatgacgatc tgtttttctc acagattact tcactccaac 3378121 gatttgtaat agatcactca ttttctcaag cataaaatcc ggctcatgct tcgccagcat 3378181 ttccggccct ttaatcgtcc atgcgactcc tgccgttttt gtaccggcgt ttttccctgc 3378241 cagcacatca tggtaattat caccgaccat aatggcttcc gccggctcgc ttcctagctg 3378301 tttcagcgct aacagcacag gctcgggatc aggctttgca ttcgtcacat catcaagggt 3378361 gacaactgtt tcaaagaatt cgccgattcc cgtgagcttg aggcccatat tgacagtatc 3378421 tcttaatttt gttgtcacaa ttcctaatgt aaagccggct ttttttaatg catccagggt 3378481 ctcatatacc gtttcatatt cagtgacgag tgaatcatgc atgtcatgat tgtacgctct 3378541 gtacatagcg atcatatcct cgcatttatc agggtccatc gaagagaacg tatcaaaaag 3378601 agacggcccg ataaatgcaa ggacatcttc tcgtttatac ttgctcggat aataatgctc 3378661 cagtgtatgc aaaaaggacg cgataattaa ttcattcgta ttaataagcg ttccgtctaa 3378721 atcaaacaga atcgtcgtta cttgtttgtc actcatattg cttcctttcc aaccgctgag 3378781 ggtttccatt ttttccacgt gtgcgcaata gccattgtca gcagaactgc tgtggtgaca 3378841 cgaatcaaaa gaagcggcca gaccggtatg ccaagcggaa taaagacaag tgtatcttcc 3378901 acgaccgcgt ggcaggcaac gagaaatata aatgccaatg tcatgtcccg cttgctcacg 3378961 ccgtcatcct cgacagcttt gatcatgaca cccgctccgt aggccagacc aatcgtcagt 3379021 cccgtcacca tcgtcataga cgtattttta ttcatgccaa gcagctgcgt aaacggcgac 3379081 agccacctgg aaaaccgata aagccagcct aaatctctta aaaactggat gataatcatc 3379141 agcgggatca ctattgccgc cagctgcaaa acaccaagtc cggctttcgt taatgcttct 3379201 gccaacattc ctagccagct gtctggcgcc gcgctcttcg cagcgataaa accgtactgc 3379261 gccgtttcct ttccgccatg ccaaatgagg ttgatgacga tggctgacac agcggccaaa 3379321 ccgatgcgca cggccaatat gacgccaatt ctgataccaa cctttgcggc aactgtcgat 3379381 tcgataatca agttatgaca gaaagaaagc ataacagcta aaataaagac ttctttcaca 3379441 gataaatcca atgttaaaat cccggcaatt cccgcataca gattcagcat atttcccagt 3379501 acaagcggaa tggccgcttc accagaaagc ccgaagagac ccattaccgg tgtgatcagc 3379561 cgtacaagcc aatccatgac aggggtatgc tggagcaaag tgaccaatag cgttaccggg 3379621 aaaatcactt tacccagcgt ccatgttgtt tgaaaacctg ctgcaagacc ggccagaaag 3379681 atcttcttca tccctcatcc ccctttgttg acgtctactc cgcgtaccgc tccttcgagt 3379741 atcccttgac gcgtctgaag atgatggctg ccacagccaa aacaatcaat acgattgaaa 3379801 tcacctgagc gatgcgaagt gaatcagtca gcattaagct gtcagtccgc attccttcaa 3379861 taaagtatct tccgattgaa taccaaatga tatagatcaa gaacatctcg cctctacgca 3379921 aattcgctct gcgcagcagc agtaaaacaa tgacgccgac aaagctccat agtgattcat 3379981 ataaaaaagt aggatgataa tattgcccat tgatatacat ttgattgatg ataaattcag 3380041 gcaggtgcag gttttctaaa aaggctctgc tgacagcctc gccgtgcgct tcctgattca 3380101 tgaagttccc ccagcggccg atcgcctggc cgagcaaaat gctgggcgcg gcaatatccg 3380161 caagcttcca gaacgaaagg tttttcactc tcgaaaacac ataacccgtt aaaatggcgc 3380221 cgattaatcc gccatgaatg gcaatgccgc ccttccaaat cttaatgatt tctcccggat 3380281 gtgccgcata atagtcccat tcaaaggcaa cataataaat tcgtgcgcaa ataatcgcaa 3380341 ttggaatggc aaacaggaca agatcaataa acgtatcttt ctgcagcccc cgtttttcac 3380401 tttccctcat cgctatccac agcccgagca aagcgccgag accgataatg attccgtacc 3380461 agtggacggc taacggcccc agctgaaatg ctatcggatt gagtggttct atcgcttcat 3380521 tcatttaacg ccaactccta ttcttcttgt tcaccgtctt caatgacgtc cgccagcttg 3380581 ttggtaaatt gttcagcggc attcagcccc atccgcttca atctgaagtt cattgctgcc 3380641 acttcgatga tgactgcaag atttcggcct gggcggacgg gaatcgtcag ttttgtaatt 3380701 tctgtatcaa tgattttcat ggtctcttcc tcaagtccga gccggtcgta ttgcttgccc 3380761 tgctcccaga gttcaagatt catgacaatc gtgattcgtt tattgcttct gaccgcgcca 3380821 gcgccaaata gcgtcatcac attgataatg ccaaggcccc tgatctcaag aaggtgctca 3380881 attaattccg gagcgtttcc cacaagagta tcctgatcct cctgccgtat ttcaacgcaa 3380941 tcatcggcaa caaggcgatg ccctcttttc acaagctcta gcgctgtttc gctttttccg 3381001 acgccgcttt ttcctgtgat cagcacgccg acaccatata tatcgacaag aacgccatga 3381061 attgctgtgg taggcgccag cctgctctca aggaagttgg ttaaacggct tgacagtctt 3381121 gtcgttttca gcggcgatct gaggacaggc accccatttt tctcggaggc gtcaatcagc 3381181 tcctgcggga tgggcatatc tctagaaaga ataatagctg gtgttacatc agtgcacaga 3381241 gaatccattc gctgcttttt ctcctcttca ggaagctgtt caaagaaaga aagctctgtt 3381301 tttccgagaa gctgcacgcg ctccctcggg taatatgtaa aatatccggc aatttcaata 3381361 cctggtcttg ataggtcact cattgtaatc gggcggttaa ttccttcttc tccgctgatt 3381421 aattccaaat tgaactgttc cattacgtct tttgtgcgaa cctttgccac gatatgttcc 3381481 tcctgttccg ggctgccccg agcttgctca caatactttc attttatcac tttcgggctt 3381541 gaacctaaaa cagattttat aaaagggggg aaaacacctc agctggtcta gatcactagt 3381601 ctgaaaaaga gtaaaataaa ggtattcaaa ttccagaaag gcggatcatc tatggcagag 3381661 agtcttctta tcaaagacat tgcgatcgtg acagaaaatg aagtaatcaa aaacggctat 3381721 gtcggaatca atgacggaaa aatcagcaca gtttcaacag aacggcccaa ggagccatat 3381781 tcaaaagaga ttcaagcacc tgcggattcc gttttgcttc ccggcatgat tgacattcat 3381841 atccacggcg gctatggcgc agatacaatg gatgctagct tttccacgct cgacatcatg 3381901 tcgtcaagac tgcccgaaga aggcacgacg agctttttag ccacaacgat tacccaagag 3381961 catgggaaca tttctcaagc tttggtgaac gcaagagagt ggaaagcggc tgaagagtcc 3382021 tctttattag gtgcagaact gctcggcatt catttagagg gcccctttgt ttcgcctaaa 3382081 agagccggag cgcagccaaa ggagtggatt aggccttcgg atgttgagct tttcaaaaag 3382141 tggcagcagg aggcgggcgg actgatcaaa attgttacac ttgcgccgga ggaggatcag 3382201 cattttgaac tgatccgcca tttgaaagac gaatcgatta tcgcatccat ggggcacacg 3382261 gatgccgatt ccgcattgct gtcggatgcc gcaaaagcag gggcgagcca tatgactcat 3382321 ctgtacaacg cgatgagccc gtttcatcac cgagagcccg gagtgatcgg aacggcgctg 3382381 gcccatgatg ggtttgtgac agagcttatc gccgatggca ttcactccca tcctttagct 3382441 gcaaagcttg cttttttggc gaaaggcagc agcaagctca ttttaattac cgattccatg 3382501 agggcaaaag gactgaaaga cggcgtatat gagttcggcg gccaaagtgt gacggtaaga 3382561 ggacgaacag cacttctttc agacggaacc cttgccggtt cgatcctcaa aatgaacgaa 3382621 ggcgcacggc atatgcgtga gtttacaaat tgctcttgga cggatatagc taatataact 3382681 tctgaaaacg cggccaaaca gctgggcatc tttgaccgaa aaggcagtgt gactgtggga 3382741 aaagatgcag atttggtgat tgtcagcagt gattgcgagg tgattctcac catttgccgc 3382801 ggaaacattg catttatatc caaggaggct gaccagatat gaaagtaatg gaatgtcaaa 3382861 cgtatgaaga gctaagccaa atagcagcca gaataacggc agatacaatc aaagaaaaac 3382921 ctgatgctgt tctcggttta gcgacgggcg gcacaccgga aggcacgtat cgccagctga 3382981 tccgcctgca ccaaactgag aatctctcat ttcaaaacat cactacagtt aatttggatg 3383041 agtacgccgg actttcaagc gatgacccga acagctatca cttctatatg aacgaccgtt 3383101 tttttcagca tatcgacagc aagcctagcc ggcattttat tccgaatgga aatgcagacg 3383161 atttggaggc cgaatgcaga cggtatgaac agctagtcga ttccctcggc gacactgaca 3383221 ttcagcttct cggcatcggc cgaaacggac acatcggctt taacgaaccg ggaacgtctt 3383281 tcaagtcgcg aactcatgtt gtgacattaa atgagcaaac ccgccaagcg aatgccagat 3383341 attttccctc catagacagc gtgccgaaaa aagcactgac aatgggaatt caaacgatac 3383401 tctcaagcaa gcgcattctg ctgcttattt ctggaaaaag caaagcggaa gctgttcgta 3383461 agctgttaga aggaaacata agcgaagatt ttcccgcatc tgctttgcac ctgcattccg 3383521 atgttacggt tttgattgat cgtgaagccg cgtcattaag accttgaaag gaacatgctg 3383581 acttatgaat atcaataaac aatcgcctat tccgatttac tatcagatta tggagcaatt 3383641 aaaaacccaa attaagaacg gagagctgca gccggatatg cctcttcctt ctgagcgcga 3383701 atatgccgaa caattcggga tcagccggat gacagttcgc caggcgcttt ctaatttagt 3383761 taatgaaggc ttgctctatc gcctgaaagg gcggggcacc tttgtcagca agccaaaaat 3383821 ggaacaagca cttcaagggc tgacaagctt taccgaggat atgaaaagcc gcgggatgac 3383881 accgggcagc aggctcattg attatcagct tattgattca actgaggagc tcgcggctat 3383941 attaggctgc gggcacccct cctctatcca taaaatcact cgggtgcggc tggcaaatga 3384001 tattccgatg gcgattgagt cctcacatat tccgtttgag cttgcgggtg aattgaacga 3384061 atcgcatttt cagtcgtcga tctatgatca tattgaaagg tacaacagca taccgatttc 3384121 ccgtgcaaaa caggagcttg agccaagcgc tgccaccacg gaagaagcga atattcttgg 3384181 tattcaaaag ggagcgcctg tcctattaat taaacgaaca acatatctgc agaacggaac 3384241 tgcttttgag catgcaaaat ccgtatacag aggcgaccgt tatacatttg tccactatat 3384301 ggatcgtctt tcataaaaaa agcctccaac cctttttaag gattggagac atggcgaaaa 3384361 tcaaactggt ctggtgccgg acgatatgtt tcttttttcg tcttgaactt ccagatcggt 3384421 gatttcgttt tgccgttaaa actgtcttcc actataatgt accaataata aacagactgc 3384481 ggttcaagat gatcccagcg gaattcagct gtgtccccgc tcttcacttg ctcccgtttt 3384541 ccgagctctt cattggtata tacgttacat tcaaaataat cggtttccac ctttttgatt 3384601 cttggcttca aatcaagcga aagggaaaat tcatccttgt tgccataggt atccgtatca 3384661 tagtagttct tatcctttac atacggagag tacgtcgata cgtgcaccat gtcattggct 3384721 tggtcaaatt gaagcaaacg caaataccct tggccgcctt ctggcccgcc ctgataatcg 3384781 gccagcattt gatgcacaag acgatccggt ttcccatcac catcatcatc cagctcatct 3384841 gtttttctca tcgcactatg ataatgcccg ctcaacacca tcacgacatt cgggttcggc 3384901 tttacgattt ctttgaatat tttctctccg attgggcttc tgtttccgct gaccagcaaa 3384961 tactcatgaa aagctaaaat ggccatccgg tcaggatgct tcttcagcac ctgattcatc 3385021 cacgcgatgt cttcatccgt aatgccccat cccatgtaca gcatgatata atcattgccg 3385081 ttgctagaaa tcaggtcata atgtccgcgg ttatttttat aggaaccgcc ataatgaaat 3385141 tttttatcaa aacgatcgct gccaaaatat ttgccaaacg ccctgtagga gccgtcctta 3385201 tgtccgacat cgtgattgcc ggccagcacg ccgtaaggaa ttccgctctt atccagaacg 3385261 gacattgacc gatcagcgtt tttccactgt ctgatatcgg cggaatcatc tacaatatca 3385321 cccgtgtgga acacatattt gatattgagc tgcttttgat tatcttttat ccattcggtc 3385381 tgtttatcaa aaatatgcgg atagctttcg gcgtaatact gtgtatcaga catccagaca 3385441 aatgtgtaca tatccttcgc aggaggaatt tcatcctgta caatcacatt cattttcgac 3385501 tcccgtacaa aatcggcggc aatcacagac gctttcagcg taaacggttt gtcatccttc 3385561 gcgacgaagc tgtcaacagg ctgccattcg tttgtccgat aattccaagc atacatcgtc 3385621 acctttctcc ccggcaaaga actgcccttc cagactgatt ctgccagatc attctcatca 3385681 attgatggat caaccgtcac ttcaaagcga tgataaggga aaagctcttt gttttctgtc 3385741 gatactgttt ttccatcagc agctgatacc cgctccaatt ctttattcgt aaatggggtc 3385801 tccctttccg gcacaaagct tttcggcggt tcagtcagtg acgcgtgctt aaatattttc 3385861 acatgattgc gcgctgtata ttgaaatccc ctataaaaac caacatccat ggcatcattc 3385921 gtcggatctt tcacccgtac agaaagcttg gccttatgcg tgtcggcttc gctgtctata 3385981 acctccggct ggtccggatg ctctcgttcg gttttaaata tcctctcaat cactgtttta 3386041 ttgcccgcga gatccgttgc tgtcactttt agagaatgtt ttcccggcaa aaggtcagaa 3386101 gatgacgtat gatatgggag tgtaatgctt tctccatcta acgacgcctc cgcttcctca 3386161 attctgctcc atttatcata catatccgcc tgcaggataa ggtttccttt atacgtttgc 3386221 ccctcggtga tattcggctc aatgtgaggt cctgaattat ctacccgtac aaccaggctg 3386281 acattttcct tcccgtcgct tgcttgaata tggtgagcgc cttcagaaag ctttgatgta 3386341 tcccactcca gcagctgtga tgtaaatagt ccgtcaggca gattgaactg aaattgccag 3386401 cttttattcg agcgctgatt atcgccaata aagagttcct tctcaggaga caccctctga 3386461 tctctgatca ccgttccatc cgataacacc aatcgggcgt ttttgactaa gaagtcatca 3386521 cggttttcag ccgtatcaaa cggagacacc ttcgaacctg aacgtatcgt aatacgctgc 3386581 agctgcttcc ctttccgaag cagtgtctct ggcaatggaa cagaataggt gcggtattta 3386641 tttgttgtat catcgaacac cttcagcact ttgccttcca tcgttaccgc gtttttaaaa 3386701 taaaggttcg ttttcctcgt atcgaatgca aaatatactt ctttttccat cgcgggctct 3386761 gtcacttgtt ttttcccgtc aatccatagc ttaatgctgt cagctcgccc ttctgtcgtg 3386821 gctttgagaa attgagttcc cgacagcgtg tctctgtttt caatattcat ccgcagaccg 3386881 tgcgccttgc ttgtttgttt aatatcaatc attttgaccg gcgttctcgc ttcattgatc 3386941 ccgtccccgg ccgccacata atactctagc tgatccttcc cgatcaattc aggcgaatac 3387001 acaatataat ggaagagatt atcgttgcgg tctttttcag caagaattcg cttaaacggt 3387061 ttgttctcat ccgtccggta gtaaaaggcc actgttttca ctaggcttcg gtcccgtatg 3387121 tcagcccgca gctcaatgct ttcagcaggg cggacaggct tgcggtcagt caaatcctca 3387181 atgaccggct tttctttatc gagcttgatt ttccgtttct ggtcgggcac ctgtgcctgt 3387241 aatacggttc cgggagacgg attcttttcc ccgattgaaa tgttcagaag ttctgctgtt 3387301 ccgttcagtg gatacttata aagcactgat gacagccggc gcagcgcatg tttccgataa 3387361 tgcgcaaccg aaatgtcctt tcctgtattc gttgatatca caacggcccg cggcctcgta 3387421 ttggccatac cctctgtctc gtctatcacc gcaagatttt ttccttcttt tagttgtgtc 3387481 tgataataac gattgaaatc cgctgacgtc aattctggat gcccggcagg cttcagccag 3387541 acgacaaacg tttcgccgga tggtatcaag atcctttcat caggtctcca aatcagatcg 3387601 gagtcaggcc cttcttttgg gtagcggtaa cggatatggt agtctttaaa atcaatcgtt 3387661 ctgtcagtcg tattaaaaat ctcaataaat tcataaccgt ctgcgcgtcc tatattcttc 3387721 gtatcaaccg ccagctctgt gatcagaagc tccggaatat gggcaaggtc agcctggtat 3387781 ccttcaagct tcagtttctt cgtctccgac tcaacccgct gcttcccatt cgacatcaca 3387841 atgtaatact caagctcgct gttccaaatc aaacgtttcg gaatttgtgc caaaaacttg 3387901 cggaccgctc cgggggtcgg gtccatcggc accattttgt agcccagctc attactttgt 3387961 ttataaaaaa gaaaggcgga aaatgcttga tacgaattat cgcgaacttg agcctcaatc 3388021 attagattgc ttctcatttc agctttcaca tcaatttgag gaggattttc aagcaagggt 3388081 atgtaatgag gcgtttgaaa tagttcctgc tgtacaacag gaaaagcttt cgattcatga 3388141 tggccgccag acaaaacgga aagaaaagac agtaatatag aagcaataac cgtgtatttc 3388201 ctcatcaaag cacctccctt ttcatgtatt ttgcgtctga acagggaagc ttatgagttc 3388261 atttttgtgc ataaagaaca aaaaaacgtc tgtctcttga aaattccact attacccagt 3388321 aaactaagga tagttaacca gttaacaatt aaatcagaga ggcaaattga tggacaacag 3388381 cattcatgat gaattatttc aagctataca acaattcgca ttaaaaaggg ataaacgcgt 3388441 ctggcaaaag gtgcagatac catccattgg catatcctca caacatcacg atcacctcaa 3388501 aaaagactgg actttgaccc agcttcacat tgtttcctgc atacatacca gccaaaatgt 3388561 gaacaacagc ttcttagcat cccgtttaca catctcaaaa gccgctgttt caaaagcggt 3388621 tcatgctttg ttgaaacaca atatcattac agtgacaaaa aagcctggca acaaaaaaga 3388681 aattttttat acgctaactg atagcggcag aaaattggcg gcattacatg aacagcttca 3388741 tgagaaagca aaggagcaat ataaacagct tttcaatgaa ttttcaattg atgatttaaa 3388801 aacagtgact gcgtttttca acttgtggat caaatatatg taaaaagagt ctcacccgca 3388861 tgggagagac ctttggaatt ctattatgcc ccgtcaaacg caacgagaag tgaaacaggt 3388921 ccgcgtgtat acagaccgga ctcagcataa caaaaatctt cctctaatct gatattccgc 3388981 atcttatcca gcacaatatt agctacaatt tcgatttcgt ttttggcaaa agctgctcct 3389041 acacagttat gaatgccgga tccgaaagcg agatgccggg cggcgccgct aaaagcgctc 3389101 ttgataccaa gatcttcccg atgaatatta aacacgtcag gctgttcaaa tgcttcaggg 3389161 tcccggttag ccgcaccgat catacaaaaa acaatcgtat cttttttgat ttccataccg 3389221 ccgaccactg tatcttggga cagctgccgc ggaatcagct gaaccggcgg tttataacgc 3389281 aatgtctccg caatggctct cggaactaac gaacggtcag ccaaaacatc attcatctgc 3389341 tcaggattgt tgagcaaatg gtagatcatc agtgccagcg tcttatcagc cggttccgtt 3389401 gcggctaaca gcacattaag aatcagtgcg agtatatcct tgtccgacag cgccatgcct 3389461 tcatattcag aagtacatag gatcgaaatt aaatctgatc ccggattgac gcgacgttct 3389521 ttaatgaccg gcatcaagta ttgggaaagc tgttcgctgc accataacga atgtgcccgc 3389581 gcttcaggag attgagagat actcgtgata aaatcggcaa ctccgctgtg ccactcagag 3389641 attttttcat ggtctctttt atccagcccg agcatgtcca tcgtgacgca caccgcaaac 3389701 gtctttccaa aatcattgac gagatcactt ttccctcttt caagataagg cgctaacaag 3389761 ttttctgcat tttgtttaat caatggagac agatgatcca gtgcgtcacc gataaagctt 3389821 ctcactacaa ttcttctttt ggcagagtgt tcttttccat gcatttgggc cagcacaggg 3389881 cctcgcatga ctggttcggc acgctcaaca agtgatttcg tcgtgaagat atccggatgc 3389941 tgaaggatat agcggacatc atgatagcgg ctgataaaat aactgtctat cgactcttca 3390001 taatgaaccg gatcttcctc ccgcagttgt gaaaaataag catatggatt gttttgaaat 3390061 tgatcagaaa gcacactaaa caatttaatc gattggctca tgttttactc cccctatcat 3390121 ccttcagatg tgatccgttt ctcagaaagc atctgcgcca tttcctgtac aatgagatac 3390181 ccttgattcg gccgcataca aatagaaaat tcatggttac tgatcttctc acccagcttc 3390241 cacggacgat gataagcaag gagtgtctct tccacctcta aaatatccgg agctccgata 3390301 aaaaacggca gctcagctat gacatattcc acagccaaat tcagcatatc ctcactgact 3390361 tcttccatca tcaaactgac gccccgcgca cgcccgatta tcgcttcacg agacatgtcc 3390421 aaacaagcat gtcgaaaatg aggctgctca aaaaatgcat gttcaacttc ttgtctcaac 3390481 agctggtagg ctttgttatc tataaaatca gaaaatgtat gaatcgcctt cggatccccg 3390541 ccatgagcca caagggctct ttctgcaaat ctcctgtttc gtgatacctc tttccttact 3390601 tttcgttcag cctttcctct cggagttcca agcgcttcta gaagattagc cgcctcatgc 3390661 cctgcaagta aaactgaaac gcttttaaat tgagctttcg cccatccaat taatctgtaa 3390721 atataatcct ctgaaaacct gctgttaaat gggctgatcc ccaccaaaac atgcctgcgc 3390781 cgttcaaata tttctctgca gttttctgtt aatgcctcag caataaaatg cacagacctt 3390841 ctttccgtta ccattccggt catctcattc acccctaaaa cttatcccgc tttaagtcat 3390901 caccctcaaa tacaagatgg aatagctaga acaactgaac aagacgaatg gcaggcatca 3390961 cttaaagttt ccaaatgttt tttaagattt taataatcat tttcaatacc catatcatga 3391021 taaatgttta ctagtaaaca ttagtcattt tatccctttt ccttccaaac gtcaatatga 3391081 tctgtgccca aatatttgaa aataaatgta aacatcacat tttccacaca ctttttacac 3391141 gcatattcag catgacatat caacaaatag tctaaacacc aacaattgac aacgaaaaca 3391201 agaaaagata aaataaaatt gttcaccagt aaacgatttg ttttattgtt tcatcgtaaa 3391261 ctattattcc taagaaagaa ggtagcctat gtctgatttg acaaaacaga tgatatacga 3391321 catatacgtg agactgctgc accttaatga acaaaaagcg aacacttcac ttcagcaatt 3391381 ttttaaggag gccgcagaag aggatgtagc tgaaattccc aaaaatatga caagcattca 3391441 cgtcattgac tgcatcggcc agcatgaacc cattaataat gccggaattg ccagaaaaat 3391501 gaacttatcg aaagcgaatg taacgaaaat cagcacaaaa ctgatcaagg aagaattcat 3391561 taacagctat cagctgacag ataacaaaaa agaagtttat tttaaattaa cccgtaaagg 3391621 cagacggatt ttcgacttac atgagaaact gcataaaaaa aaggagctgg ctttttacca 3391681 attcctcgat tcattttcac aagaagaaca aaaggctgta ttgaagtttc tagagcagtt 3391741 gacgtcaaca cttgaagcag aacaaaccga tgggactcca gacaaacctg taaagtaaac 3391801 aaaaaggcgg tgtacacttt ggctcataca aaatcaaagg cagtattgat cttatacact 3391861 gtttgcttca gtgcattttt tgcatcttta agccagaaca tttattcacc tattcttccg 3391921 atcattaaag aatcattcca tgtttccaca gctatggtga acctgtcagt ctcagttttt 3391981 atgattgtga cagcaataat gcaaattata ttaggagcga tcattgattt taaaggcgct 3392041 cggatcgtct tgattaccgg tattctggca acggcagcag ccagcatcgg ctgtgcggtg 3392101 actactgact ttaccttgtt tctgatattc agaatgatac aggcagccgg ttccgcagca 3392161 ctgcctctta ttgctgccac aacgatcgga cagctgttta caggaaatga acgcgggagt 3392221 gcaatgggaa cgtatcaaat gctcctgtct gtcgcaccgg ctattgctcc agttctagga 3392281 ggattcatag gcggagcagc cggatacgaa gggatttttt ggatacttgc ggccatctct 3392341 atcgttttgc tggtgacaaa cagcatcacc tttcctaaag attctccaac tgaatctatg 3392401 cagcaagcca aaggcaatgt gttcgctcat tataaatcaa tatttacaaa tcgaacaggg 3392461 aacgtcattt tgactttaag ttttgttctc tttttcattt attttgcagt aattgtctac 3392521 ctcccaatat tgctgacaga gcattaccat atagatgtgg gtatagcagg actgttatat 3392581 ttgccgctgg cgctgagcac gattgcaggt acgtttctgt ttaaaagaat acaggcaaaa 3392641 atcgggctgc acaccttgtt tatcggaagc aatgtgattg ccgcctgcag catcatttta 3392701 tttgctgtta cacattccgt ttctctcgtt ctcatggctc tgacgctggc actgtttggc 3392761 atctcgatgg gggttattcc tcccttgtac tctacaatga ttactaatga atttgagcac 3392821 aacagaggga gtgcaatcgg aatgtttaac tttatccgat atacaggcat ggcagcaggt 3392881 ccgatggtat ctgcctactt gctcacaatg atgccgtctg ccatgtcctt tagcctccta 3392941 ggccttggat ttgccgcatt gagcttttgc cttcttccgc caatgttttc gccgcagaag 3393001 cgcacgaaac aaaaaaagca ccacatgtaa aaaagctgcc tttgcgggca gcttttttta 3393061 tttttttcta agcggctcta aaatgccttt ttgaatcagc aaatggaaga ccgacaggat 3393121 aacggatgcc catatcgctg tgccgaagcc gtcgatttga aagctgtcac ccataatgga 3393181 cgcggtcatc ataagcgtga tggcgttaat cacaaacaag aagagtccaa gcgtcaccat 3393241 ggtgaccggc agtgtaaata taattaaaag cggtttaatc agcacgttta agatcgataa 3393301 aatgaggctg gcgataatcg ctgccccaat gctgctgata tggatggagt caatatatcc 3393361 atcaatgacg attaataaca atgcattgac taaaatgctg actgcccatt ttaccatgtc 3393421 atttcatatc cctttctgac gggacgataa aaatccaaat gatataaatg agcaaaaccg 3393481 gcaagacact tgtcataatg gctaagatga cagttatgac tctgaggagt gatgcgtccc 3393541 aattgaaata ttccgcgaga cctccgataa caccggcgat tttcttattt ttttctgagc 3393601 gataaagctt attcattcga tcacctctgt gagtacttta gtttgatggc gcctgttagt 3393661 gattctgaga agacggtgat gttttgatca tgtgcctgat ttgaagtgaa catcatttct 3393721 ttttgaatcg tatcattttt ttccttcagc atctctacat ccattaattc atgggacagc 3393781 gtaccaagat tgcttttcag ctctgccttc actgcgagat cgtccggaat tgcaagctct 3393841 acatttccag tcgttgtttt tgcataaatg gagcggcagt ctgattctgt tacgttaatc 3393901 gcaatatttc cgttaaagct ttgaacgtca atggattcgc ttttccctcg gagatcgatc 3393961 aatccgttaa tggtttccgc ttctatcgta ccgcagctgt ggcttgcgag cttaatttgc 3394021 ccgttggccg tttcagctat ggctttttcg gctgttaaat acgagaacga cagcacgccg 3394081 tttgtcgttt tcgctgagaa ctcttttaca tgtaaatgtt cccctctgac tggaccgtta 3394141 aacagcttca cccgaatctt atcatactcc ttctgaggaa tatacaaagt gacattcgtt 3394201 ttcatcgtct ttttctcagt acggataaaa aacttattac ctttgatttc acattcaata 3394261 tgctgaagaa atgcgtgtct cgccgcatcc tggctgtcag cgcgatatac cttcgcctgg 3394321 cattccgctc tgatatcgtc atcttcccaa gggacgatat ttacgctgcc attggcaatt 3394381 tgcagctcaa cactggaaaa gtcagtatct ttaaattgaa aaatgtgctg aacatcatac 3394441 gcatggccaa agtttaaatc aaggtcaact tccttgacct ttttcacagc agaatcaatc 3394501 cagtcaaaca gcttggctcc taaagacggt ttgccgcttt ctttttttgc cgttgtaaat 3394561 ggctcttcct cgtcatgaac gtgaactgag agcgctgtga ttttctcttc tttttccttg 3394621 tagtcgctgt caagcttttc aatcagtgtc aaagcttctt gtgctgtaag ctttccttcc 3394681 tcaacaagct taaggattcg ttccttttct tgcttcatta cgatctcctc cccattgtct 3394741 acttatgctg cacgcaggac cttaatgccc tgaatcacat tccaaatgat aatgccaatg 3394801 acaactaaga aataaataac cgctcccccg atgattacaa atacaggaag caagctgtct 3394861 ccatcaatcg caacggctcc gccaagtaaa gcaataaaaa ggaacagcca gccgacaaac 3394921 ggaacaatgt gagaaataag agagcgtatc gcatggcgtt ttgtttcttt ctcatttaca 3394981 acaaaatatg cgacaatcgg cacaatgatt ggcgcaatga acacactgaa ataacaaagt 3395041 gatgcaataa tagcttgatt acggttcaat tcattccaca ctcctattgt gaattgtcca 3395101 tgacaaaaga tcagggacgt tttacttatt tatacgttta aaatctcttc aggtttcaaa 3395161 ttcattcttt agacatgctc cgatttacgg aaattggatt ttaaaaagtt ttagaagtag 3395221 aatcttccgg ctataccgat tacaatatgt aaaaagctta cggcaaccaa ggaggctgga 3395281 caagcaatgg agaaagatcc cagtgactat acagtaacac aagaatcagt gttaaagctg 3395341 attcaggaac aaaaaagaat gaatcgtgaa atgatcaccg agcttgagca gattcacgga 3395401 cccttcccga tctctcacga tatccaatat ataaaagtgc tgctcgacag cagcaacaca 3395461 catattgttc aagatttaat gagtgtaagt aagcagctgt ataagaagac tttgtaattg 3395521 cggaaaacat atcattcatt ataactgaaa caaagctaaa ggttagatga caatatcttg 3395581 ccttttttgt tttgaaaaaa caagtgattc cctggctgtc acaaaatgat tgtaacaaaa 3395641 aaagcctgcc ggcacatcca gttaatggac tctgtcggca agctgtaact atcagaaaga 3395701 gatagccgtt caaaattaac gtaacaattg aagcacgttt tgcggctgtt ggtttgcttg 3395761 agcaagcatc gcttgagaag cttgagaagg aatgttgttc tttgtgaact cgctcatttc 3395821 tttcgccatg tcaacgtcac ggatacggga ctcagcagct gtcaggtttt cagaagaagc 3395881 accaaggttg ttgattgtgt gctctagacg gttttgtacc gcaccaagtt tagcacgttg 3395941 gtttgagaca ttgttgattg cagtatcaat actttcaagt tgtgtatcaa aaggagtatt 3396001 agcaaaatct gttacattaa gtgcgtttac tcctaaagca gttgatgaca tgctgtcaat 3396061 gttaactgta agctgctggc cagcatttgc tccaatttgg aaagtgaaac catcagtttc 3396121 agtaccatct aataactttt tgccgttgaa ttcagtacga tttgaaatgc catcaacttc 3396181 ctcaataagc gcatccattt catctttaat tgcaccaaga tcttctgctt gttgtgtacc 3396241 tgtgtttcct gcttgaacag taagttcact tctaaaccta ttatgccgta aagaaaaagc 3396301 ttgcctgcta agcccaagga tggacttgcc gacaagctgt cccctcttaa cagagggttt 3396361 taagatgtag ctgtttcttt tgctttcaag agcgatttca tgcgtgtttt gtcacgttcg 3396421 ataacaggct ttaaataacg gcctgtatac gattcttcaa cttcagtgat ttcctcaggc 3396481 gttccagacg cgacaatggt tccgcctccg gctccgcctt ccgggcccaa atccacaatg 3396541 taatcggccg tcttaatgat atcaagattg tgctcaataa ccagtacagt gtctccgttg 3396601 tctaccaacc gttgcagcac gacaagaagc ctggcgatat cgtcgacatg caaacctgtc 3396661 gtcggctcat ctaaaatgta gagcgtacgt ccggttgagc gtttgtgcag ctctgacgcg 3396721 agcttcacgc gctgcgcttc tccgcctgac aaggtcgtcg ccggctggcc gagcgtaata 3396781 taacctaaac caacatcata aagggtttgg agcttgcgtt tgattttcgg gatattttca 3396841 aagaaagaaa gagcatcttc aaccgtcata tcaagcacat cagagatgct ttttcctttg 3396901 tacgtcactt caagcgtttc acggttatag cgtttgccgt gacacacctc gcatggaacg 3396961 tatacgtcag gaaggaagtg catttcaatt ttaataatcc cgtctccgcg gcaggcttca 3397021 catcgtccgc ccttcacgtt gaagctgaaa cggccttttt tatagccgcg gaccttcgct 3397081 tcatttgtct gcgcgaatac atcacgaatg tcatcaaata caccggtgta tgtcgcaggg 3397141 ttggatctcg gcgttcttcc gattggcgcc tggtcaatgt caatgacttt atctaaatga 3397201 tccaaacctt taatctcttt atggctgccg ggcttcgctt tcgctttatg aagcttttgc 3397261 gccagcgcct tatgcaaaat ttcattaacg agtgtactct ttcctgaacc ggaaacacct 3397321 gtaactgctg taaacgtccc aagcgggaac ttggcattca cttttttcag gttgttttct 3397381 gatgcacctt taatttcaat gtaacgtccg tccggctttc ttctttcagg aggcaatggg 3397441 ataaactttt tccctgataa atagctgccc gttaatgaat ttggatcttc catcacttct 3397501 tccggcgtac ccgcagatat cacctgtccg ccgtgaatgc cggctcccgg tccaatatct 3397561 attaaataat ctgctgccat catcgtgtcc tcatcatgtt cgacaacaat cagcgtgttc 3397621 ccgaggtctc tcatattttt cagagcgctg atcaagcggt cgttatcacg ctgatgcaga 3397681 ccgatagacg gctcatctaa aatataaagc acaccggata aacgcgagcc aatttgagtc 3397741 gccagcctga tgcgctgcgc ctctcctccg gacaatgtac ccgctgccct gctcaatgtc 3397801 aggtaatcga ggccgacttt gtccagaaag cttaagcgct ccacaatttc gcgcaaaatc 3397861 aaattggcga tctgcatatc cttctcagaa agggtaagat ctttaaagaa ggcaagtgcg 3397921 tcggcgacag acagctcggt aattttccca atgtggcggc cgtcaatcag tacggcaagc 3397981 gcctctttct ttaaccgata gcctttgcac gtcggacaag acttctgaga catatactgc 3398041 tccatttgct cacgtatgaa atcggagcct gtctccttat agcgtctttc aatgttgcgc 3398101 aatacgcctt caaattgaat ttcaccttcg cggatttgtc caaaatcatt ttcatatcgg 3398161 aaataaatca ggtcatcccc gctgccgtac agcactttat ccagttgatg cttcggcaaa 3398221 tctttgaccg gcacatccat atcaatcccg tagtgggtgc agactgcctc aagcagctga 3398281 ggataatatt gtgagctgat cggtgtccaa ggggcgaccg cattctcctt caatgacaaa 3398341 tcttgattgg ggatgacaag atcggcatcc acttcaagct tcattccgag accgtcacac 3398401 gtcggacacg ccccgaacgg actgttaaac gaaaacagac gcggctcaag ctcaccaatt 3398461 gaaaatccgc agtgcggaca ggcatgatgc tcgctgaaca tcagctcttc ctcaccgatg 3398521 acatcgatca taacccgtcc ttcacctaaa cgaagcgccg tttccaatga atctgacagc 3398581 cgggctgcca cgccttcttt cacgacaatc cggtcaatga ctacctcaat ggaatgcttc 3398641 ttgttctttt ctaattcgat atcgtcggaa agctcagcca tctcgccgtc aattctgact 3398701 ctgacatagc cttgtttcct aatctgttca agcactttga catgagcgcc ttttcggccc 3398761 gagacaatcg gcgccagcac ctgaagcttc gtccgttccg ggtattccag aattctgtcc 3398821 accatttgct cgatggtctg ggatgtaatc tcaattccgt gttccggaca atgaggcttc 3398881 cctactctcg catataaaag acgcagataa tcataaatct cagttaccgt accgacagta 3398941 gacctcggat tgcggctcgt tgttttctga tcaatgctga tggcgggaga gagcccctca 3399001 attgcatcca catccggctt atccatttgc cctaaaaact ggcgggcata ggcagacagc 3399061 gactcgacat accgtctctg tccttcagca tatatcgtgt caaaggcaag ggaggattta 3399121 cctgatccgg acaaacccgt gacaacgaca agctgatctc tcggaatcgt tacatctata 3399181 tttttcaggt tatgcgccct ggctcccttc acctctatcc gatccatagc catttgttca 3399241 tcatccttcc gcttttagct ctaaaagtaa atcgcgaagc tccgcggctc tctcaaagtc 3399301 aagcgccttg gcggcttcct tcatttcatg ctccatctgt tcaacgactt tctggcgttc 3399361 tttcttcgtc attttcgaca gcttcggcgc ggcttttgtt ttgtattccg ctttatcctc 3399421 agctgctact gtggcacgaa tgacatcgcg aatttcttta tttatcgttt tcggcgtaat 3399481 gccgtgctct tcgttaaacc gctcctgctg ctcgcggcgg cgttttgttt cattaatcgc 3399541 aatttccata gacttcgtta ttttatcggc gtacataatg acgcggcctt ccgcatttct 3399601 cgctgcccgt ccgatggtct ggatcagcga ccgctccgaa cgaaggaaac cttccttatc 3399661 cgcatccaaa atcgcaacaa gggatacttc gggaatgtcc aaaccttccc tcagcaggtt 3399721 gatgccgaca agcacatcgt acttgccaag gcgcaggtcg cggataattt caatccgttc 3399781 aagcgtcttg atctcagaat gcagatagtt tactttaatg ccgatttcct ttaaataatc 3399841 ggtcagatcc tctgacatct tcttcgtcaa agttgtcaca agcacccgtt cattccgctc 3399901 gattcttgct tgaatttcgc cgatcaagtc gtcaatctga ccttcgattg gacggacgtc 3399961 aataagcggg tcaagaagcc ccgtcggacg aatgatctgt tcgaccattt catctgtatg 3400021 ttcaatctcg tacggccctg gtgttgctga tacatacacg atattgtgca tatgcttttc 3400081 aaattcctca aaacgaagcg gacggttatc aagcgctgat ggaagccgga agccgtgatc 3400141 cacgagcacc tgtttccgcg cctggtctcc gttaaacatg ccgcgcacct gaggaattgt 3400201 cacatgcgac tcatccacca cgatcataaa atcgtctggg aaataatcaa gaagcgtata 3400261 cggcgttgaa cctggaggcc gcagagtcaa atgtcttgaa tagttctcga tgccggagca 3400321 gaaacccatt tcacgcatca tttcaagatc atatcttgtc cgctgctcta aacgctgcgc 3400381 ttcaaggagc tttccgtttt catgcatgac cttcagctgc tcctcaagct ccttctcgat 3400441 attttgaatc gccttctcca ttttctcggc ccgcgttacg aagtgggatg ccgggaaaat 3400501 cgcaacatga tctcggtcgc cgagaatttc tcctgtcagc gcatctactt cccgaatccg 3400561 ttcgatttcg tcaccgaaaa attcaactct gacacaatgc tcatcacggg atgccggaaa 3400621 gatttccact acatccccgc gcacacgaaa tgtaccgcgc tgaaagtcga tatcgttgcg 3400681 ggcatattgg atgtctacaa gttttctgag cagctcgttg cgctcaattt ccatttcagt 3400741 ccgcagtgac acgaccattt cccggtattc ctcaggcgaa ccgaggccgt atatacaaga 3400801 cacactcgca ataataatga catctctgcg ctcaaacaaa gctgatgtgg cggagtgtct 3400861 cagtttatca atttcatcat taatactagc gtctttctct ataaatgtat ccgtttgagg 3400921 cacatacgcc tccggctgat aataatcata gtagctgaca aaatactcga cagcattgtt 3400981 cggaaaaaat tccttgaact cactgtaaag ctgtccagca agggttttgt tatgggcaat 3401041 cacgagagtc ggcttattga cttctttaat caaattggac accgtaaatg ttttcccagt 3401101 tcctgttgca cccagcagag tctgatgctt cttgccctcc tgaattcctt tcacaagctt 3401161 ttcaatggct ttcggctgat ctccctgggg ctgatatttc gagactaact caaagcgatc 3401221 tttcacaaaa ataagcctcc gtttctttaa cgaaatcttc ctatagatat agtaacacaa 3401281 tggaaagcaa aatcactaaa aatacgaact aaagttcggt ggttttttat ttccagctgt 3401341 ttttgtgtat aaaaaacctg cttttaaaac gtaaaagcag gtattcagtc tttatattca 3401401 ttatgtccga tttattcttc ttttttctct gcagcttttt tggccatata cagtccgcca 3401461 gccacaagag acacaacatc caatcctaca ataaaatacg tttctgtata gccttttaaa 3401521 taagaggcaa acagcaatgc agctgttaaa gcgatcgcca cataatgatt aaaggtgact 3401581 ctagtaaata gaacaacaag cataaaaggg aaaaacaatg caaaaacggc ttttgtaatc 3401641 aacaaaaacc ctcctcaggg attcttcatc tgatctgatt atagtaaaaa atgaagaatc 3401701 ggacaatcgt gcattcgctc cctctactta caccataccc cttttcagcc aaaatcaatc 3401761 accatatttg cattttggtg ccggtcaaaa cttattccat ggtgccgctg ttctaatcag 3401821 cggcactttt tttattacat catcaagtcc gccgccagat tccgagaata aaagaaaata 3401881 ggcatacagt accagtacgg ccgcattttt caggataata taaccaactt aactattcat 3401941 tttatttagg actttctgcg tttgacagca ttttcctgaa aacctacaat taaatgatag 3402001 tgtttactat cattttttaa acacaggctc cgcaataaaa agactagaga gaaaaacaaa 3402061 atgaatgaag aaaagagggg tttcaaatat gtattctgtt ttatttcgcc aggcagaaga 3402121 gtccagccag ctggctggag caaaaggaat gaatttgatt aaattgacca aacacggtct 3402181 tcctgttccg gacgggttta ttattcaaac gaatgcgctc gcacgtttta tggaggacaa 3402241 ccagcttcaa gagactagtg aaaacgtcga aggcgggatc atttccggaa cattttcgga 3402301 tgagctgaaa gatgagctga ctagttcctt ttataagctt agagaatcat atcgatccgt 3402361 agccgtgcgt tcttcgtctg cttcggaaga tttagaaggc gcctcattcg cgggtcaata 3402421 tgaaacctac ttaaatatca aaacagagga agagtttctg gctaaagtga aagaatgctg 3402481 ggcctcattt ttttctgggc gggtcagcag ctataagaaa aaaatgaaca atcaaatcgc 3402541 agagccgtta atgggaatag tcgttcaggg gctgatcgat tcagaaatgt caggtgttat 3402601 cttcagccgc aaccctgtta cccatgatga tagagagctt ttaatcagcg ccagctacgg 3402661 gttgggtgaa gctgttgttt caggaaatgt taccccagac acgttcattg ttaataaatc 3402721 ttcgtttgag attcagaaag aaataggtgc aaaggaaatc tacatggagt ctgcggcaga 3402781 aggaattgct gaaaaagaaa cgagtgaaga catgcgcagc cgtttttgcc ttacagatga 3402841 acaagtgatt gaattggctg aaatcacaaa aaaaaccgaa gacctgtacg gatatcctgt 3402901 tgatatagaa tttggaattg ctgatcatca aatatacctt ctgcaagctc gcccgattac 3402961 aaccattgat caggacaaaa aagcggcaga agaaaaacgc agcttcatga ttaccgacac 3403021 tgatatgaat gatttctggc ttaacatgga gtctaatatt gaaggtccgg tgagtccgtt 3403081 attttcatcc ttcatcgtgc cggcattgga atatggcttg aagaagagca tgcaaaagtt 3403141 tccgattggt gtagttgttg atgaagtaaa actttatcgc ggacatattt attccaaaaa 3403201 ccaaggcgga cagcagcctc cttctgaaga ctgcggcaaa gagcttttcc cgattttatc 3403261 ggagcatatg tatgacatca tcaatcacac atacctccct ttttaccgga cactggacca 3403321 gctcgcacaa actgagcata ccgcagaaag cgcactggaa gcttttcaaa aactaaaggc 3403381 cttttatctc acggcttatg aagagcactt taatatcgtt ttcccgcaaa tccttttaac 3403441 aaacaaactg caagcgatgt atcaggacat tcaaggagag tccgaaaacg ctcattttta 3403501 cgagatgctg acaggaaaaa tgaacaaatc actggaaacg gaccgttgct tatggctatt 3403561 ttctgtggaa gttcaggaga acccgaacct tctggccatt tttgaaaaca acaagcctga 3403621 acagctccag gagaaattgg aacaaacaga tgagggaaga cacttcctga agaacgtcca 3403681 tgaattcttg caagaatacg gatggagatc tgttaaaagt catgatctga ttgaacaaat 3403741 ctgggtggaa aatccgtatt tcgctctggc caatattcaa aattatgtcc gtaatggcta 3403801 tcattttgac aatgaatttc agaaaacaaa agaaaaacga gagaaattat acaatgaatt 3403861 cttggaaagc atagaagatc ccggtttacg caccgaattt gaccgctatt atcaatggac 3403921 actgaactct gcaaatataa aagatgatca ccacttttat attgacgcca tgctggatgc 3403981 caaggcgaga atctttctgc tgaagatagg tgaattgctg gcggaaaacg gtgtcattca 3404041 agatcgggag gacctttggt tcttatatga cgacgaagtg gaacaagcgc ttcttcaccc 3404101 tgtatccctg caagaaaagg ctgaaaaacg cagacagatt tttcatgagt atgagctggc 3404161 ccaagccccg gcctacctcg gcaccccgac aaaagaacag ctcaaagcag ctgaagaaat 3404221 tgtcggcgct gtgatagagg atgaaaaaaa cacagagaat catatttttg gcattgcggc 3404281 atcaagcggc attgcgacag gtccggtgaa aatcattcgg gacgccaatg aattttctca 3404341 attcgcgcct ggagacgtac tcgtttgcaa gatgaccaca ccgctatgga ccagcctgtt 3404401 tcaagacgcc aaagcgatta ttacagacac aggcggcatt ttgtctcacg ctgcgattat 3404461 tgcccgtgaa tacggcattc cagccgttct cggcacacgc acggcaaccg aaagactgcg 3404521 agacggtgac atcatcactg ttgacggaag cagcggcaaa atcacagttg tcagccggtc 3404581 ctgatgcgtc cccctctttc ttatacaagc ggggcgggtg tatacttgtc ctgccagtat 3404641 attcgtgagg tgaaacgtat tgagaccgac aaacaagaga atccttgatg ctgccatgca 3404701 gctgctcgtc aaaaaaggat atcgcgcaac gactacaaaa gaaattgcag aaaaagcaaa 3404761 tgtaagtgaa gcgacgattt tcaggaactt taaaaacaaa caaggactag ttgaggcttt 3404821 gctttctcag cattcttcaa acagaggcag cattttggaa caaacagaag gggatttgta 3404881 caaagacctg cttcatatcg gaacctgtct cttggaggag ctcgaacata gaaaagatat 3404941 cattaaaatc agctttcgtg aaccggccat gtttcaggat gtcattaacc acgtcactga 3405001 atatccccaa tctatgaaac agctattggt tgattatctc aaaacgatgg gtgagaaagg 3405061 ggttattcag acaggaaatg aagcggaaca tgccgacgtg ttcatgtcga ttatcttcgg 3405121 ttatttcatt caccgtctcc acttaggaga ccgggtcata tcaatgcccc aggaaaaaat 3405181 gctggagcat agcacagctc tatttgtcaa aggaatttct gctgattaac tccttggcat 3405241 aataaaaagg aggatcccaa tgagctcaag aaaagaatgg gcgctgatcg tctcgctatt 3405301 attgggggcc attctggttc ccattaactc aacgatgatc gcggtcgcgc tctcatctat 3405361 ttcccatacg tataacgagt ccatcgcaag catcacttgg gtggttaccg tttatttaat 3405421 cgtgatggca gtcacacagc cgattgcagg aaagctcggt gacatgtacg gcaataaaac 3405481 aatgtactta tggggagtcg gcctttttct aatcgcatct ctaggctgcg ccctttcacc 3405541 gagtctgctc ctgttaattg tctttcgggc attgcaggct gtcggcgggg cattgcttac 3405601 gccaaacagc attgccatta tccggcatgt tgtttctgaa aaacgcctac cgaaagtgtt 3405661 tggatttttc ggactgggcg cgggacttgg tgcagcactc gggcctttta tcggctctat 3405721 actgattgac agcttcagct ggcattcgat tttttgggtc aacatcccgt tcctcgccat 3405781 tgctttattt acggcattaa cgatgtttcc tcaatataaa gaaaataaat ctgacgcgcc 3405841 gctggatatc atcggctctc tcttgcttgc aggcagcatc gtttccatta tcctgctgac 3405901 gaaaaatgag gctccatggg gatatactgt atacagtgta ttgatacttc tttttgttcc 3405961 gctttttttc agaagagaaa aacgtaccca gcaccccatc attgactttg cactgtttaa 3406021 aagctcaacc tttacaaatg cgaatctatc agtcttgtta agcaatttga tgatgtatgc 3406081 cgtcttattg attatgccgt tatttatgac gaaccaattt gggcttaata catctaacag 3406141 cgggatggcg ctttctgtat tttcgatctt catgtcagcc agcaactggg tgggcgcgca 3406201 gctccatcac aaatggggag ccaaaaaaat catttttctt tcatttgcca tgatggctgg 3406261 tgcgaatcta ttatttttgc tgttaagcag ctcgcattct gtcttgttcc tcatgctctc 3406321 tcttatcctt ggcgggctcg cttccggagt cggtctgacc agcatgcagg tttcatccct 3406381 tgccacagta gaccccggta tgtcaggagt ggcatctggg attttctcga ccttccgtta 3406441 tttcggaagc atcatttcat cagccttaat tggcctgatt tcgggatatc acaccctatt 3406501 tatgattctc tttgctgtat ccatcatcgg cgtttttgtt tcattgggca tcaaatctga 3406561 tgaaacggca cggatagaaa aaaactcagc gtaacacaaa acagcccggc atcgcatcat 3406621 cctgcggtgc cgggctgcct tttatgatcc cgaagcgact gcttcgtctt cacggtcatc 3406681 ctttacgaag aggatgccca attcatgatg ttctccttca taagaagctc gctggtcaaa 3406741 acgaatttct ccattcaaac cgataatttc aagctttaca tatgcacggt tatgctgaag 3406801 cgcttcatag aaatcagaaa cgttcttaac cggtatgcca ttgactttcg ttatgatttc 3406861 cccgattttc aattccagat cctcagccgg cgtattgggg ataatcccaa gcaccattaa 3406921 gccctgatcc cttttcgaga aataaaacgg agccgcgtta tcattcactc tttgctttat 3406981 ggacagaaaa atacgcccta acaaagcggt acagaccgct gcacccgcaa gcggcgtcca 3407041 cagtaagctc gctgcaccga gaactgcgac ggcaagaccg agaatacaaa cgcgtttcgc 3407101 tgtgatcctt atactcgttt caggcagcga tccctgtacc ctttgtccaa atccgacaaa 3407161 gtaaggaatc catagaaaat ggaatgagcc gccgggaacc gtaaacacgg gccaccagct 3407221 aaggtgcgat tctaaaccat taccgggcac gagaaggaac agcggcaaaa gccaaacccg 3407281 gtttgccagc tgctgtccga tcggcaaacc gcggctgctt acgacaagtg ccggtgatgt 3407341 tctcacatgc gcagaacgat aagcaaccgc tccttcagtg ataatcagca aacctagaaa 3407401 cacagccaca gccggccaaa caactgcaaa tccttgcgga aatctctcca gaaagggctc 3407461 cgcctgatat atttgcagtc caaaacctat cagcatactc acactgacga tatatgcagc 3407521 agacatccag tttgcgcgaa gagtgaacgc tgccgctgca gtgataacgg caataatcgc 3407581 aagtaaaccg agaggaatcg atattccgag tccacctaaa ataactgaca aaagaagacc 3407641 tggaatcagt ccctttgtat atgtaaattt cagatcatca taaatatctg ctattcttgt 3407701 atgaaaggtt tttcgttccc gtttgattct tacatagccg aaagccaagg ttatgatgat 3407761 aaaaaaccag aaaagcgggt gtaagaagaa caagcccgcg ctttttaaca gttcaattcc 3407821 ccattgaaca gacactatct ctcaccgcct caagccaaac atgttactca tattctatca 3407881 aatattaaat ggcttggata tcctcaggag agtttatctc tcttgcgtca tccacagcgt 3407941 gacattcgat agtgaaaaat cctttaaata gtggtttaca tccacatcca ataacccgct 3408001 gattagatgc atcgaccttt ttatatctgt cagattaatt cctaatcgct tatggttttt 3408061 cattaagtag ttaaaataat gtttggcgca ttcctcatta atgtcattta ctgattcgac 3408121 attggtgtaa ttgaccaaat atctgctgaa cagcataaga agacttagtg cttttgtagc 3408181 tgaaaatgtt acgtcttgtg ttctgtcttt taattgttcc actaattcat aatatttttt 3408241 tttcacgcac aatacttgcc ctcttcaatt gtgaaccccc attttcttta tacagataag 3408301 cacgggccag tataagcagc agtactggag tgctaacaag cattctcgct aacgttactc 3408361 tttaaatacc tgtcgttcag ctgccattaa cctgattact gttcttttta gaaccttctt 3408421 atattgtatg aagtaaacaa agactaggca acttgcaaaa gtttcatttt aaatgcatat 3408481 taactcgtta gaaagtctct ctcatatatt gatatcgggt aataacagtc ctttataaat 3408541 gtttatttgt gaaaattttt ttaatttctt gtcaaaaact cattttttat gtgacttatg 3408601 atccataatc tctttaagca caaagaaaca ggagatgaaa taccatctcc tttaattgac 3408661 aaataatgat ttcaatgctg tttgaagctg caaatcattt ttttcatctg attttttctt 3408721 ttctatctgc tgatttaatg tctctgcagt gcgagtgtcg atcacaccgg ttttattcag 3408781 cttgttttga tcctgaaaag ccataaccgc ttttttcatg tctttgctga aatagccatc 3408841 ctcacgtccc ggatcaaagc tgagaccttt taacaatacc tgcgcatgct tgacgtcttc 3408901 attgttcatg tccactttaa gcggctcttt cagctgtaag ggcccggcgg aaaaataatc 3408961 gggctgctta atcgcaatgg tcggttcaat tcctttctta tgaatccagt ttccatttgg 3409021 cgtcagccac ttgtaaagcg ttaatttgat gttgctgccg tcccccattg gcacagcctg 3409081 ttgaaccgtt ccctttccaa aagacgtatc gcctacaaca tcataatggc cagcttcctt 3409141 taatgcgccg gcaagaattt ctgatgcaga ggcacttcct ttatccgtaa tcacattgac 3409201 agggtacgct tttttatggg tcaatgttga aaaataacgt tttttatctc cattgcgttc 3409261 agcaatctga atatacggct gatcctttgt aacgaaatgc ttaagaattt cttccacact 3409321 ttgaagatat ccacccgggt tgccgcgtac atcaatgaca agtccttcta tttctttttt 3409381 ctcaagctcc ctcagcgctt ttgcaaaatc ctctgcggtg tgctcagaaa aagtagagat 3409441 ggcaatatat ccgacagaat gcccctgtac ttttttctct gatgcaaaaa ccgtttcgag 3409501 cggaatctca gctctcttga tccggaatga caactgcttc ttcgttccag gccgctgaat 3409561 cttcattgaa acgctggacc ctttttttcc tcttattttt aacacagcgt ggtttaaatc 3409621 cttgccggcc atcgattctc cattgatgct gataatttca tcattaggct tcaacccggc 3409681 tttttccgct ggcgatttct tgaatggaga aacaataata attttgccgt cttccattcc 3409741 aacctcagcc ccgatgcctt caaatgagga atcaagagaa tcagaaaatt gcttagctgt 3409801 ctgcttgtcc atgtaaacag aataaggatc atttagcgta gacagcattc cctggatggc 3409861 tccctcgagc agcttttctc tatctacttt ttctacgtac tcattcgaaa ttaactcata 3409921 cgctttttcg attttgtcca tagctttatc ccgttcagag tcagcttgtg ccgtcgcggg 3409981 aactgctgca gtctggggct tatccatctc aagcaggttg attcccgcat atacaccggc 3410041 gcctccgaac agcatgctcc ctgctgctat cacagccatt attttttgat tcatccttta 3410101 ctcctcctgt atgccagact gtctttacca aaacctagag atagtatatg taaaggatgg 3410161 agatttcatg taatcataga agaaaaagaa ggcaaatgaa aagccgtccc gaaaacggaa 3410221 cggctttttc actttatact cgcagaaact tgcggatgga agtcagactt ccccatactc 3410281 caattactgc gccgattgca atcagcacta gcgaaacttg gaatacaaat ggattataag 3410341 gaagaagaga gacaaatgat ccttgaacct ttggaacgac ccatccgatg acgtattggt 3410401 aagtgctcag caccagtgca atcggaatca cagaaccgaa tacgcctagc agcaatcctt 3410461 caaggaaaaa cggccagcgg ataaaccagt ttgtcgcgcc gacaagcttc atgatttcaa 3410521 tttcttttct tcttgcgaaa attgtaattt taatggtgtt ggaaattaag aacatcgccg 3410581 taaataccag gccgataatt aacgcgattc cgatgttgcg ggaaacgccg accactttaa 3410641 acaaacggct gacctcttct tttccataag tgactttata aacatgatcc attttttcga 3410701 tctttttcgc cacgttcggc gtatcatgcg gatctgtcgt tttgacgaca aacgcatcat 3410761 taagcgggtt ttcctgatcc ttcattgtca gggattttcc gctgtcacca aaactgtcaa 3410821 ccagctggtc aagctctttt tctttagatg aaaaagtgac actctgaatg cccttcagtt 3410881 ccttaatatc gttctgaagc ttgtcctgtg ccttctgatc tgcagtcaga tcaatcagca 3410941 ctttgatttc gacttgtttt tctgcattcg tggccatgtt attcaaattc agcataatca 3411001 ctaaaaacac gccgactaaa atcagcgtaa cggttacagc actaatggat gcaaatgtca 3411061 tccatgtgtt tctcccgaga gatttaaaac tctcacgcaa gtggcgcccg agaattttaa 3411121 tcatatgaac catactcccc tcttgactca tcacgcacaa tgataccatc ttcgattgca 3411181 atgacacgtt tcttcatggt gtttacgatt tctttattat gtgtcgccat cacgactgtt 3411241 gtcccgcggt tgttaatttc ctccagcgtc ttcatgactt cccaggacgt atccggatca 3411301 aggtttcctg tcggttcatc agcaatgaca acatcagggt tgttcacaat tgatctggca 3411361 atagatacac gctgctgctc cccgcctgaa agctggtcag gaaattgtcg cgctttatgc 3411421 ttcagctgca cgagatcaag cacttcaagc acccgtttct taatgacaga cggctgttct 3411481 ccaatcactt caagggcaaa tgccacattt tcaaaaacag taagtttcgg aagaagcttg 3411541 aaatcctgaa agacaacacc tattttgcgg cgcacgaaag gaatctcttt ttctttaatt 3411601 gtcgcgagat ctttatgatt gattaaaatt tgtccttttg tcggtttttc ttctctgtaa 3411661 atcattttaa taaaagtaga tttacctgct ccgctcggac caacaacata cacaaactcg 3411721 ccgggatgaa tggtaacaga aatcccattg agtgctttta cgccgttcgg ataggcttta 3411781 tatacttcct tcatctctat catgaaatca cctaatcttt tatatcattt tatctatcac 3411841 acggtcatac tcttcgaatg cattcgacaa tttatgaccc attcatttgt aaaaagatga 3411901 aaaatctgaa agttcccttt ttcaatacac ttcattatac gtcaaattta gacataatac 3411961 tattacagtt tcttttcatt catattgtca aggcataaaa acatccttgc cagcactcgg 3412021 caaggatgtt tttatcttac tttttttctg acagccattt ggcaataaca gcggcttcgt 3412081 tatcatctac aagccccttt ggcatattgc cgcggccgtt tttaataatg ctttcaattt 3412141 tgtgttcatc gtatttgcct ccgacctctt ggagattagg ccctgacaca ccttctaaat 3412201 ccttgccgtg gcagcctacg cagctttgct gatataattc ttccccttca gatgcagtgg 3412261 cttccgtctt gctgccagtg tctgtcttct cttcttttgc atcgtttgat ccgcaggcag 3412321 ccaacagaac agaaagcgca aatccaatca ttagtatcga taactttgat ttcatgttga 3412381 gaagcacaac tcctttacga tctcttccat attataacct cgtttaagcg cgtttgaaac 3412441 cctcgcccag cacctcgctc gcgtctgcta caattacaaa agctgactca tcaatctgtt 3412501 tgacgatttg tttcaatttg gtgaattcag tttgcccaac cacgcacatt aaaatcggac 3412561 ggtcatcgtc agtatatccg ccgactgcag aaatttttgt cacgcctctg tcaatcttct 3412621 gtaagacagc ctccttgaca gcctgctcct gctttgtaat gatgagcgcc atttttgaac 3412681 gattaaagcc gacttgcaca acatcaatgg ttttgctgga cacatagacg ccaagcatgg 3412741 catataagcc ttgctcaata ttaaatacaa tcatagccgt aacaacgatc attccgtcaa 3412801 tgatggcgag acacttcccc aatgacagac cggagtactt atgaatgatc tgtgcagcca 3412861 aggctgtacc tcccgtcgaa cctttcccta agtacacaat accaattccg atacctatcc 3412921 cgacaccgcc aaaaatcgcc gccaggagtt catgatgagt ggcgggctga atatcccttg 3412981 tcagaaacac tactagcggc aaaaacacag aacctgcaag cgtctttagt ccaaatttcc 3413041 cgccgagcaa aatgacgcca gcaataaata aagggatatt aataatccac tgtacatacg 3413101 ctgcttcaaa accatatgat tgtaaaatcg tactgatccc gctgaccccg ccggcggcaa 3413161 tcttattcgg aagcaaaaat acattaaagg acacggccgt aatcgctgct cctatcaata 3413221 tgtatacata atcccgcaaa atccacaatg ttttattccg tacgtccatc atatatcctc 3413281 cgtttcttcc aatgctctcc gatagcattt taatccttcc ctgattagat gtaaataaca 3413341 cccaaataca gtggtaatat gctaaagcag cagtgaaatc aaggatataa gaaataaaaa 3413401 aacacacccg tatgcatcag gtgtgttttt cagcttatga aagcttagaa cgcaggtagg 3413461 catcaataaa cgtatcaatg tcaccatcca ttacagcttg aacgttcccc atttctgtat 3413521 tggtccgatg gtcttttacc atggaatacg gatggaatac ataagaacgg atttggctgc 3413581 cccagccgat ttctttttgt tcaccgcgaa tttcatccag ctctgcctgc tgctcttcaa 3413641 ttctgcgctg atacagcttg gccttcagca ttttcatggc tctttcacgg tttttaattt 3413701 gtgagcgctc cgtttggcat gtcacaacta cgttcgtcgg caagtgagta atccgaacgg 3413761 ctgaatccgt cgtattgacg tgctgtccgc ccgcgccgct tgcacggtac gtgtcaactt 3413821 taatatcctc cgtacgaata tcaatatcaa tttcatcgtt aaattcaggc atgacttcac 3413881 atgaaacgaa agatgtgtgg cggcggcctg atgaatcaaa tggtgagatc cgcacaagac 3413941 gatgaacacc tttttctgct ttgagatacc cgtaagcgtt gtgtcctttg atgagcaatg 3414001 tcactgactt gattcccgcc tcgtcacctg gaaggtaatc gagagtctct actttaaagc 3414061 cgcggcgctc tccccatctt gtatacattc taagaagcat agagccccag tcctgtgact 3414121 ctgtaccgcc agcaccaggg tgcagttcta aaatcgcgtt atttttatca tacggctcgc 3414181 tgagaagaag ctgaagctca aactcattga actcttttgt taatgacttt agttcttttt 3414241 caagctcaag ctggagatca gtgtccggct cttctttcaa aagatcatga gtcatttgta 3414301 attcttcgtg ggattcattc aattttttat acgaattgac ataatccttt aaaccgtttg 3414361 cttcatttat aaccgtttga gctttttgct gatcattcca gaattccgga tcagccattt 3414421 gttcatctag ctcagcaatg cgggcctcct ttgattcgag gtcaaagaga ccccctaaag 3414481 tccgctaaac gagaagccat attttcgagc tctgctctaa tttctgataa ttccatttca 3414541 ttcacctcat taaaagatcc gcaggcgcct gcaggcgccg cggtcagtaa acttgccggg 3414601 gcgaactatt cagtacggcc gcagcaattt ttatattttt tcccgcttcc gcagtggcat 3414661 ggggcatttc gtccgatatc aaccactttg cgaaccggtg ctttctttgc ttttttgtta 3414721 tcgtcgcctt cttgcggctg atgagctgtt gtttgacctt gtacaacctc ttcacgctcc 3414781 agattgtttt caatctcagc tttcatcaca aattttgcga cttcgtcctc aattgattca 3414841 atcatatgct caaacatcgc aaaaccttcc atttgatact cacgaagcgg gttcgtctgc 3414901 gcgtaagcac gaaggtgaat cccttggcgg agctgatcca tcgcatcaat atgatccatc 3414961 catttagaat caacggcacg aagaacgata actttttcga attcgcgcat ttgctctttg 3415021 ccgaattgct cttccttctc attatatttt gtgatgatgc gatccataat gagctcaagc 3415081 atttcatccg gttctttgcc gaagatatcg ctcttctcaa gtgcaccttc atcaagataa 3415141 gttgtgttga taagatcaac tagaccgtca agcttccact cctcaggaag ctcttctctt 3415201 ggcgtatagg ctgcaattgc gcgttcgaga gaagacttga tcatattttc aacgatttca 3415261 cgcaggtttt cagagtcaat gacttcaaag cgctgcttat aaatgacctc acgctgctgg 3415321 cggagaacat catcatattg cagaagctgt ttacgcgaat cgaagttatt gccttcgacg 3415381 cgtttttgag acgattcaac cgcgcgagat accattttgc tttggattgg agtagagtcg 3415441 tccatgccga agcggtcaag catcgccatt gtccgctcag ctccgaatct gcgcatcaat 3415501 tcatcttcca tagaaagata aaattgagta atccccgggt ctccctgacg tccggaacga 3415561 cctcgaagct gattgtcaat ccggcgtgat tcatgtcgtt ctgttccgac tacagcgagc 3415621 ccgccaagct cttttacacc ttcgccaagc ttaatgtccg ttccgcgccc cgccatgtta 3415681 gtcgcaatcg taactgcgcc tttttggccg gcctcttcaa tgatctgcgc ttcacgttca 3415741 tggtttttgg catttaacac ttgatgcgga attcctttgt ttttaagcag cttagaaatc 3415801 aattcagatg tttcaacggc aaccgtaccg actagaacag gctgtcccgt catgtaacgc 3415861 tgtgcgacat cctccgcaac tgccttaaac tttccttcca tcgtgcggta aattaaatcc 3415921 gggcggtcat cacggacaac aggcctgttg gtagggatcg tgacaacctg catgttgtag 3415981 atgttgcgga attcttcttc ctctgtctta gctgtacccg tcataccggc aagtttttcg 3416041 tacattcgga agtagttttg gaacgtaatc gtcgccaagg tcatgctttc gttttgaatc 3416101 tcaagccctt cctttgcttc aatcgcttgg tgaagcccct cactgtagcg gcggcctttc 3416161 atcagacgtc ccgtgaagga atcaacaata acaacctgtc cgtcttccac tacatagtca 3416221 acgtcctttt gcatcgcaac gtgagctttt aaggcctggt tgatatggtg gttgagcgcg 3416281 acatgcttca catcaaagag gttatcgatg ccgaatgctt tttccgcctt cgtcattcct 3416341 tcttcagtaa gctgtacagc ttttgttttg atatcgtacg tgtaatcctt ctccgctttt 3416401 aacgtgcgga caaaagcatt tgcctgtacg tacagcttag tggattttgc agcttgtcca 3416461 gaaatgataa gcggtgttct tgcttcatca attaaaatag agtcaacttc atctattacc 3416521 gcaaaatgaa gcgggcgctg aaccatctgc tctttataaa gaaccatatt gtcacgcaaa 3416581 tagtcgaagc caagctcgtt gtttgtggag taagtaatat cagcggcata agcttcccgt 3416641 ttttcgtctt ttgacattga gtttaaattc aaaccgacag tcaaaccgag aaactcgaaa 3416701 attttcccca tttgctcagc gtcacggctt gccaagtatt cgttgacagt cacgacgtgt 3416761 acgcctttac cggttaacgc atttaaataa acaggcaggg tagacgttaa tgttttccct 3416821 tcccctgttt tcatttccgc tatatttccg tcatgaagcg ccacgccccc catgagctgg 3416881 actttaaacg gaaacatgcc tgttacgcgg cgtgaagctt ctcgaacaac agcgaaagct 3416941 tcaacaagaa gatcatccgt tgtcgcccct ttttcaagac gctctttaaa ttcaattgtt 3417001 ttatgtttca atgcgtcgtc agagagattt tcatagtctc cgcgaatcgc atcaatatcg 3417061 ttagcaattt tttcgtatct attcagcgta cgttttgttg gatcaaacat tttatttaaa 3417121 attccaagca tttataacgc tcctctatca tcacacgcct attttagagg catgtataaa 3417181 taatttacta gtccatgtat acctctcatt atcatatcat accttttgtt atttccaaag 3417241 aatttgcaaa taagaaaaac aaaaaccttc cgcggacatc acggaaggct tctcttcatt 3417301 attcagtcgg ttcaattaag ccatatttcc cgtcatttct gcggtacacg acatttgtaa 3417361 ggtttgtttc cgcatttgtg aaaacaaaga aattatggcc gagcatattc atttgcaaga 3417421 tcgcttcttc actatccatc ggctttaaat taaagcgttt ctgacggacg atgtccaagc 3417481 tctcctcctc ttctatgtca tcctgaaccg caatatctgt atcagagcca agaccgtttg 3417541 ccaataaata ttttggagag ccctgctcac ggaatttacg gtttactttc gttttatgct 3417601 tacggatttg acgttccagt ttgtttgttg cgagatcaat tgcgttgtac atatcctcgt 3417661 tatgcacctc ggaccgaagc gccagatctg tcatcggaat cgtaacctca accttagact 3417721 ccttgtcatt gtaaaacttc aagttgacgt tcacatcagc atccacgcta tggtcaaaat 3417781 agcgctccag cttgccgatc ttcctctcga catgatcctt taacgcgggt gtcacttcaa 3417841 tattttctcc tctgatgtta tagttcatca aagaacgcct cccttttatt aaggatatgt 3417901 atctatttct cttttaccct ttacaattcc tgctgaaaca taaatctttt gtgaaaattc 3417961 agtgaacttt gtcgaatttt gtttgtattt gctctgttat tggcggttcg gaggtatatg 3418021 tatatgctga ttgaacgaaa caaatacctc acacacgcct aattgattaa aaagggttcc 3418081 atacattgat gaatagacag catccatttt ctataatgaa tcagaaaatg ttcctttaaa 3418141 tactcacaga actcatgaga gggaaaagag aaagagacca attgatcaaa ctccgcaaaa 3418201 atttggtcaa atgctttcac acaaatttca gcacaccgcg aatccataat gaagagaagt 3418261 gttgaatgtg ttgaatccaa ataaaaaaag gcttggatca gatcttggta gatccgatcc 3418321 ccttctgttt ttgataaatt ctcttcagcc tctatcaaat aacacaaccc ctcttcgatg 3418381 gtaaaaagaa gatgataata agctgataaa agcgtataat cttcaatgct cttcaaggca 3418441 ctcacctatt tacgcttgtc ataatatgtg ccgtcaatcg taatgttgtt ataagggttt 3418501 aaatacgtcg tatgcatcac acgttttctt ttcatctgct gaagttctgt tgcgattgac 3418561 tgcttcagtc tttccatttc cttcacaatc agctgatccc atgtcaaaat aagtttcatc 3418621 tgctttcgct cttcttctga aagcggcaga gatatctcct gaatcagttc agaccgtgta 3418681 gccacaaagt cttcaatttg ctttaaaagt tcatcgcttt ccggcgtatt ttgtatgtgt 3418741 gacagcatac tcttcgtctc agtgtatagt tgatctatat tattcatgcg atcccgcctg 3418801 atccgtgccg gtccttccgc tcactttgaa tggcttgttt ccaagcatcg cgaaaatctg 3418861 ttacataacc ttcaacctca gccagcatgc ccgtatcatt tttgatattt gcctgtacca 3418921 atctgcgata catataatcg tacatcgcac ccatagaagc ggaaagctct atgttacggt 3418981 taagtgtaaa atttaattcc tgaataatat tttgcgcttt aatcagattt tcatttttac 3419041 gttccatatc atcattctca atggcctgag cggcaagtct tataaatttc aaacagccat 3419101 tatacagcat aagcgtcagc tccccgggtg tagccgtatt cactgaattt tgctgatagg 3419161 ctgtatatgg attttggatc gccatgtgtc atcctccaaa ttacatttat tgtacaagaa 3419221 gctgtgataa ataggacgct tgttcgttca ttttttgaat cgcagaatcc attgcactga 3419281 attttgaata atagcggttt tctatggtat tcaatctgtc ctgcatatca gttatttcag 3419341 tacttatcga gtttaaattt tttccaatgg aatagctact agctcccatt gtcgagttcc 3419401 cagctttagc ttcaatactt ttcacagtac ttctaagtgt attagtaatc cgcttcataa 3419461 tacctttatc gctatagtta ctatcatttg ttccacttgt aaaaagatta gcaactcctt 3419521 gaggatcttc tgctattttt gctttcaatt tctcttcgtt aatctctaag tgccctcgca 3419581 gttggtaagc acttgaagtt gtgatgccaa attcagttaa ttgataggtt ttcccatccg 3419641 cattcacttg agtataaaag tcagtccgca tttggttcgt gccagtgctg atgcttgaat 3419701 cgtttctcag caatccgctt ttcgccttct cctcccagag ctctacctct ttatcggaca 3419761 tggcttcttt ttgttcactc gtgagtggcg tatagtctcg gtatttttct tctttcagct 3419821 tttcattcag gctgtcaacc agttcattgt atttatctac aaactctttg atttggttat 3419881 aaatcccatc aacatcagta gaaacagatg tggtaacagg gcctgtggct gcagttgtat 3419941 ttttaatcga ataagtaaca ccattcaccg tgaaattgtt tgtcagcttc tccatttcaa 3420001 agccgttgat tgtgactttg gcatttgtgc cttctttgta agcagtaagc ttattatcag 3420061 catccaaaga aaaaccaagc tgaccggaca taaagtcagc tgtagcagag tctgctgcct 3420121 gtatgcttcc tcctgcacct gttgctttag aagaaaacgc aatcgtttct acgtactctg 3420181 taccattcca aattttatct ttaaatgctg atactcctag atctgagctg ttaagtttag 3420241 aaatcacatt atcaatcgta tcggcactcg tcacactaat gttcactgtt tttgctgttg 3420301 tttcgccagg cgcaacaacg ttaaatgcca aattgtaatc gccttgtgtg tatcccgtat 3420361 aattgtttgc cttatacgtt gctgcagttg ccaagctcgc cacttcaaca gtagacgaag 3420421 aatttggcgc acttacgctt cctgtagcag ttaacacaga ctcattagag cttgtcacag 3420481 ttttgctctg atacgtgctc ggatatgtca acgtattttt agacatataa tcttgcaatt 3420541 cttttatttt tgagtttact tcacgatagc tgtcacgctg ccattcaaga gtctgctttt 3420601 tttgtgtcag cttatcaagc ggcgctcttt ctgtctgcat cagctttgat acgatatcat 3420661 ctatatccat tcctgacgcc agacctgtta ttcttgtgac catctcaaac cactcctatt 3420721 ctactttttt tcatctacaa ataacccaag aaattcagtc atagccgcat aaaaatcaag 3420781 ccaccgtttt ggtggaattt cgcggatcac ttcatttgta gagtcctcta ttacctttac 3420841 atagtattca tttaacttgt catgaagctc gaacttcaga tgaacttgcg aaggttccaa 3420901 aagcttgttc atttccccca ccatttcagc aagattggta tatgaaactt gatgaacagg 3420961 aacctcgtta tcattatctt tctgattatg tatttgagta tcataacgat cccaaacagg 3421021 ttgtaacgta gtgagccttt caatgttcaa ttgatcatcc cctatgcccc aatctatcgt 3421081 ttatatcgac taagtcgaga taagattaca catatttttg gaaaaaaatc ttctgtttta 3421141 gatttcttgt atggaaatac atttataaaa agttagtgga gaatccggtt attatatcat 3421201 gagttagtga caggatgagg aatgattagg agatagaaat ttaaattaaa agaccctggc 3421261 aacgccaagg tcttttttaa aattaacgta ataattgaag tacgttttgc ggctgttggt 3421321 ttgcttgagc aagcatagct tgagaagcct gagaaagaat gttgttcttt gtgaattcgc 3421381 tcatctcttt agccatgtca acgtcacgga tacgagactc agcagctgtc aagttttcac 3421441 cagaagcgct taagttgtta attgtgtgct ctagacgatt ttgtaccgca ccaagcttag 3421501 cacgttgaga agaaacttgg ttgatcgctt catcaacaac tttcaattga gcatcgaaac 3421561 cgatatcagc agtatctgct gcattatctg cgaattttgt tacgtcaaga tcattaactg 3421621 aatgaagagc tgcaattgaa ccatcagctt ctttaattcc aagagcgtca gcacccatat 3421681 cctcaatatt tacagagatt tgctgtgtag catttgctcc gatttggaat accaagttct 3421741 tttgatttgc aggagtagct gtgtcaactt tgtaagtgcc atcgagcaat ttcttaccat 3421801 tgaattctgt acgatttgaa ataccatcga tttcatctgt taaagctgaa atttcatctt 3421861 gaatagattg caaatcagtt gctttgtcct gagttccagt gtttccagct tgaacaacta 3421921 gctcacgaac acgttgaagg atcgcatgag tttcagttaa tgcaccctca gctgtttgga 3421981 taagagagat tccgtcttga gagtttttag aagccatttc aagacctctg atttgtcctc 3422041 tcattttttc agagatcgca agacctgctg cgtcatctcc cgcacggttg atgcgaagac 3422101 ctgaagaaag tttctccatg ttcttttggc tcgcactgtt gtttgaagac aaacggttca 3422161 gtgtgttaag cgctgcaata ttgtggttaa ttctcattgt tttgttcctc cctgaatatg 3422221 ttgttaaggc acgtccttgt gcccttattt tgtaactggc tgagtctttt gcgcctcctc 3422281 ccggctacat cattaatatc ggattgtctc tgattttgtt aatacaaaaa taaaaaaatc 3422341 ctcacttttt ttgtgaggat aatgcggaga tcacatcgct ggataacgct gctgcacggt 3422401 tattttcttc ctgaatggtc aagtaaattt ctttcctgtg aatatcaata tgctttgggg 3422461 cgtcaattcc aagcttcact tgatcccctt caaccgcaat cacttttact tcaatatcag 3422521 cacctatttg aatcgcttcg tttattttcc gcgataaaac tagcatgatt ctcctccaat 3422581 cggatgcttt gtcgtatatg aggagtcgtg taaaacgact tgcttagcca tcatgttctt 3422641 gcgattcaca ataatgggag ccaataaatt cgcagtagac ttttcaaatg gctctgccat 3422701 agtcaatatt gtcatgactt ctacgtcttg aatattatcg atatccaaaa gttcagcagt 3422761 tgattcatca agatcaaatt cataattctt aaaaaagata aacggactta cgacgataaa 3422821 cgcaagattt tctgaagtga cggactgcag tgccacgaat ggagagtctt ctgaaagcgg 3422881 aagtatgacg aactgttttt cttctaaaaa gcctggaatc ccgctttcaa aaagaatgat 3422941 ttgttcttct tttatgttca tttggccatg gtacttcgta tgaatgatca ttgttcacga 3423001 tccttttctt tttacttttc gggtgattct ttcgggtatt ctacatctat atttaaatca 3423061 gggtattgaa gcatgtcaac cttaacattt cctggcgtat attcaacaat tggcttatgc 3423121 ggctcagcct gaataacagg ctttcgcggc gtaatctgca catcaagctg tgacggagta 3423181 tattgtattt tcaccctcga aagagaagga gcataatttt cgcctaattg aatttggtgc 3423241 atttcagagt tcctccttgc ttgtgaagcg attgggttcc ccttattttc aatcttcata 3423301 agctcgtcgc cttcttctgc agtgcgtgct attccctcca ttacatcctc atgcccttgt 3423361 tgggcggctt cttcaattct cttgaaaaca tgctttctgt ctaattcttc ccatgcttgt 3423421 gtctggtcaa tcgtgagttt tccaggtgtc accgatattt ccatttccgc actcggctgt 3423481 tcgatctcta gatcagcttg aggctgctcc atttttaagc tggcaggcgt cgttgttaaa 3423541 ccaatttttc cttgaacact atgcataatc aatctgggaa tctgcatcac tctacctcct 3423601 gaactataaa aaaagcgaac tcctaagagc cgcttacttt aaaaagtcaa tcaatgtagg 3423661 ctgaacaatt tgcgcattaa cggccagagt agccctgtgc acactttgct gcgcaataaa 3423721 ttcagttatt acttcttcca gttctacatc ttcattgtct gataacactt tggtagctgt 3423781 ttcttcttgc gctgacagtc ttgtattaac cagttcaaga cgattatatc tcgctccaag 3423841 atcagatcgt tcagcgctca tgccgtcaga aaaatgatca atatcattta aaacactgtc 3423901 catgccatct agcgaaccag aatttagtgc tttctcaaaa gaatcaagca tttcaaatac 3423961 attctgcccg ctttcagaag tgcctccaaa agctgacttt ggatctgaat tcactttcaa 3424021 tgacatatta tttgatatat tgactacgac atcagctgta tcagaaattg tataagttcc 3424081 gtctccgtta tctgtaaccg gaggcttatc tgaatttgtg ccattaaaga tatatctgcc 3424141 gttcacttgt gtattcgcaa tatttaaaag ctgttccttt aactgcttta cctctacgcc 3424201 aatcgcttgc cgctccggct cgccgtttgt atcattttga gcttcaaccg ctaattctct 3424261 gacctttgac aagatgtcaa ttccttctgt aatgtttgtt tctgtgtttt cgagccaggt 3424321 aaaggcttga gaagcattgc ttttgtactg ctgcacttga gacagttgcg tattatactt 3424381 taagcttttc attgctacta caggatcgtc ggaagctttt gagatttttt ttcctgaaga 3424441 aatctgcgac tggagtttat ccagcttcga gtagcttgaa ccgatatatc tcagtgagtt 3424501 ttgctgtatc atgccttgtg ttactctcat gtgactctac ctaccttcct ccaacaccca 3424561 tgccgttgat cactttatca agcaattcgt cttgtaaagt caccattctt gcagctgcat 3424621 tgtatgcgtg ttggaattga atcatattcg tcatttcttc gtctaaagaa actgcgctca 3424681 tttgctgacg gtttatgtca gcatcattca gctgtgtttc tgtattagac gccagtcgat 3424741 tagcctcttg agcttcgatc cctagctcgc caatcagacc cgcataataa tctaaaacac 3424801 tagtttcttt accgttaatg gttattttac cggttaaaac atttgctaat tttgtagcat 3424861 ttgcgttatc gttggctgcg ccagtcagtg agaaagcaat gtttgcgcct tttgaatcta 3424921 ttatgctgtc agccactttg atcttgcccg ccgcgccctt ggcaggttca gtttcaccgc 3424981 cagtaaaatc aaaaaagtct ccgccttgtt caccgctctt ggtcacacca tttctgtgca 3425041 cttcattgaa agctttcgcg aattcaagcg ccatattgtc aagatcagaa agcatttccg 3425101 ggtatacgcc cttttcttgg ccatctgctg ttatataccc ataagactct ataaacccta 3425161 aaagggatcc cttgctgcta aaggactccg cctgtacagc tgtatccccg attgaaatac 3425221 ttgatactaa cccagtttca ttatcatagt tggctgcaag ttctgaaacc tcgtaatttt 3425281 taccgtccaa aacagttcct agcgactgtt tatttttatc aaggatttca attgatacag 3425341 ttccttcagc agatgcaagt gcattcccgc ctgatttgtt gtagctgact ttgatatcaa 3425401 ccattgagga taatttatcg atcagcaaat ctcgctggtc atataagcca ttcggaagaa 3425461 gcccgaccgg ctctacttgt gcaatttgct tatttaaact gtttaactga gaaagcagag 3425521 aattgacatc caacacagtt gtatttagct ctgcttttaa attcgattgg acatttgtaa 3425581 gtgattcaga aatataatta aacgtttcag ctacagcttg tccttttcga gcaacaacag 3425641 aacgtgcact ttcttcattt gtattattcg ataattcctg cagggaattc caaaacgaat 3425701 tgagcacact gttcaagccg ctgtcatccg tttcatttaa aacgccttcc atttgggaca 3425761 gcgcttttgc cttcgtgtca tagtatccgg cactgttgtt ttgaagacgg tattggtagt 3425821 caagaaagat atctcttatt ctctcaactg attttccttg aacgcccgta cccatttgtc 3425881 ccgctgtttt ttctgcattt ttagatacag cagggaaata gtcagttgcc tccaatgaga 3425941 cccgctgtct tgtataacca tcagtattgg catttgccac gttatttgca gtagtgctta 3426001 acgctgcctg ctgagcgctt aacgcccgcc ttgcagtttc aagccccata aaggtagatg 3426061 tcattttctg aattcctttc tgctaagctt ttgaatcaaa cagtttcatt ttgctacttt 3426121 tcggcagctc agctttaatt gatttgctgt aattgaagtt attttcctta ggaaccagca 3426181 tatcgtacga aatagagatg aattgcagcg cgtctcttgt cagctgccta ttcatctcat 3426241 ttactttttt cagacgtccg agaacttgag aaagagattc gtatagttgt tccagctctt 3426301 ccttttcact gcctgaggtt ttggcgatac atgcggaaat agtattattt tcgctatatc 3426361 cgagaaaggc cgaagttgtt ttgatccggt catcttctgt ctgcgtgatt gcttgaatat 3426421 atttttgctc ttttgtcaaa atgttagaaa gctcttttgt tttgccggct ttgagcgctt 3426481 ccgtcttttc ttcagacagc gtgagcaggt gctcatgcag aacgcaaagt cgcttcaatt 3426541 gttcaataat tgccttcgct gacatgggct ttctcctttt ttattgcttt ttataaaaat 3426601 taatcatatt tttcgcaata tgatttgcgt ctactttgta tgacccgttt tcaatttgcg 3426661 ctttaagctg cgcaattttt tcctgtcgtg aaccagtgac tgcgtcggat gcatgttgca 3426721 tttctttagc ctgtgatgaa atttcaattt tatcttgagg ttgtgcaaca gttttttgca 3426781 ccgcttgctt atcataattt ttttgatatg gattaacgga ttgtgttcca aattgattga 3426841 ttttcatagg attcctctcg ctttccgttg cagtctttaa acaatcttaa cccttttatc 3426901 gactgcgttt tcagttagtt tagggaatca gctgtttttg gtattatagg catagtatgt 3426961 gtctttttta ctattttctt tctcgatttt cagagcatcc tcgtggttca aatgatccat 3427021 ttgatcctta atatcagact ggcaagcctt gcagaacttg ccttctctaa tcgatgtccc 3427081 gcacctttca caagggtatg ccaaattagg aagatgagtg atctgaattc gcttctgcct 3427141 gatgaatttc aatatcagct cttcttccac acctgtttcc tcagttatcc ggctcaaagt 3427201 tgattgccgg ttttcctgtt ttcttaaaaa tttatagaca gtctcaaatg atttttcttc 3427261 ttccttaata cacgcctgac atacggtttg cagctttgtt tttaaaaata aagcattgca 3427321 tttcggacaa ttagccagtt ctcccatctt tttttctcct tattagataa tatgcctgtg 3427381 tcaatttcta gtgattatat cggcataaaa acagaatcat ttagcttctg atcaaggtaa 3427441 aagatgacac tgaagcggct tttccttttt ctaataagca gcgggctgcg aagtgcaagg 3427501 tggcgcctgt tgtataaaga tcgtctatta aaatgatatt cataccttct gctgaattat 3427561 tttttgtatc aaaaatgcac tctgacagca ggcgttctgt tttctttttc tttgactgtt 3427621 tctcattatt caggcgaatg aggggatggt gggaaggccg gtctaaacat tctgccaaga 3427681 gatgtgcctg gttaaatccg cgctcttctt cccgttcctt gctcagcgga ataggtacaa 3427741 gaacaaaatg cttatcgggg taaaccttag aaaaggttga agaaaaatca cttttaaatg 3427801 catttatgat ttctgcatct cctctaaatt taaaacggga gagcgtttct ttcatcatat 3427861 cattatatgt gtaaactgaa cggttttgac gcaatagcaa actgtctctg atccttgttc 3427921 tccacacctc gcaatccctg catacggcat gaacagattg aggtctgccg cacagggggc 3427981 agatatgtcc tgtgattttc tttaatttgc ttctgcaaga ataacaaacc ttttcatcag 3428041 gctttagtaa aaaaagggct ctccatgtaa catcttgaga aaattgcgaa tcacataata 3428101 aacagatcag tttatgaatg cctcctcctg cttcgtttga cataaatcgc ttggactctc 3428161 tgaaactact gcagcagatt cagccaaaat gacaagcatt gctgtgtttt tttgtttatc 3428221 taccagctca gctttcgtat atgcgatctt tttaaaatca gtaacgtagg atggactcac 3428281 tttgtttaaa gaaagtgcca atacatcgtt ttggcatact tggcaagtac aggccatatg 3428341 aagctggtcc atatatcggt cgagcagttc tttcattacg atttcttttg aattgacaag 3428401 catttttaca gctcctcatc atcggttata tgagtatact gtaccacgtt ttcaaataat 3428461 ggctagtctg tacattcaac ttttgctgcc aattcattca tttcttttat atgctttctt 3428521 gcatcgagca tactctttgt tttgccgaag tgaaagtaaa tgacatcgcc gtccgcatat 3428581 tctttatgcc ggccggttct tcctgcaatt tgaacaagtg cgctttccgt aaagatagac 3428641 gattccgctc ctagtacacc cgtttgcacc ttggggactg tgacgcctct ttccagtatt 3428701 gttgttgtga ttaatagatc gagctgacca tctctgaatt gctgcacttt ctcctttcta 3428761 tgcttgtctt ccgcgtgcac agatgcggtt cggcaatgaa cacctttaaa gcacgcagca 3428821 gccttttcca gaatagaaac ggaaggaacg aataaaaaaa caggcctccc ttcttttaca 3428881 tgaaactcta tccatctttt caccgctggc ggaattttat ttcggtttaa tttcttcttc 3428941 cagtttccac accatacaaa gcgcggttcg ggtaaaggtt tccggtggtg tcttgcgggg 3429001 atgcgaactg aatgtaactg tccgttcagt gcttttcttt ttaattcttt aggaggtgtt 3429061 gcacttaaat aaacgagggt gctgtttttc tttcttgctt tttgaacagc gaattgaagg 3429121 gtttgatcag cagaatatgg aaaagcgtca acttcatcaa tgatcataac atcgattgca 3429181 tctttatatc gcaaaagctg atgcgtagtg gaaatcataa gcggagatag ccgccctttg 3429241 tcatcgcttc ctccgtaaag cgctgaaatg tcagcaccct gaaaggcagc cttgagtctt 3429301 ggagcaagct ctaatacaac atcggtgcga ggtgttgcaa tacatacacg cagtccttga 3429361 tttaacgctg attctatacc aggaaacagc atttctgttt tgccagcgcc gcaaaccgcc 3429421 cagatgagga gctcttcttt ttttgatatt gcttcaatta aaacattggc ggctttttgc 3429481 tgtccgcttg aaagcttgcc atcccatgtc agcttaatag acttccagtt tgattcattt 3429541 tcctctttcc atgaatataa aggaacctcc tcactcactc tgcccatcat gacacaggaa 3429601 cggcaataca gcttattctt tccagatgag tgataaaaag aaaaataccg ctgatcagtt 3429661 tgtccgcacc tattacatct atatctccgt ttatttatgg atatagaatt ttcagcagtg 3429721 atatatccat tcttgatatg ccattcaatc atctcatcgg aaaatgagag ctcagtcctg 3429781 agcaaatgac ggcttcgaag cgtctgctgc aattcttttg aaaaggaact gtttttttca 3429841 actggcacat tcacatagca cgcctccttt cgaaacagta tgcctgaatg aatattttct 3429901 gtccaactat taaaataaga atataaaaaa atctccgctc taaaaacgga gatttggcct 3429961 tatttaaaac accagcaaat tcctaacgca ccttcaccca aatgagtgcc gattaccgcg 3430021 ccaaaatagc tgttataaaa ttcaacatga ggatattttg cagaaagctc ttcaatgatt 3430081 ttcgctgctt cttcctctcg attagcgtgg ataacagcag ctcgcatagg caacccttta 3430141 ctcgcatctt cgtctaaaag ctcataaatt cgcgaaattg cttttttacg tgtgcgaatc 3430201 ttctcaaaag gcacaattac cttattgtca aaatgaagga taggctttac ctttagaaga 3430261 ctaccaatga aggcttgggc gctgcttaat cgcccgccgc gctgaagatg ggctaagtca 3430321 tctaccataa aataagctcg aactgttttt ttcatttctt ccagttcttt tataatatct 3430381 tccggcgatg atgctccgtt tttgattaat tcagcagctt taagggcata aaagccttga 3430441 gccaagcagc tgatctctga gtcaaatgga tacacatcaa tattgtcgac catcgaatca 3430501 gccgctgctg cactgctgaa tgttccgctg atcccgctgg aaagatggat actgataacc 3430561 gcatcataag acttgccaag ctcttcatac aacgcaacca gctcgccgat tggcggctga 3430621 gaagtcgtcg ggagctcatt atgttttttc acttcttcat aaaagctttt ccagtccaac 3430681 tcaatttctt cacggtaagt ctcctcccta aaaacaacct ggagagggat catatgtatc 3430741 tgatgttgtt cacgcatttc tttcggaata tatgccgtgc tgtctgttac gactgcaata 3430801 ttcatagctt cgatacctgc cttattgctt tataactcta ttgtaaggga aacggcagcc 3430861 taaaaaaaga cctgcctagt aaaaggcaag tctcctatta tactatctca tttctaccca 3430921 gccattttta atggcgacca caacggcttg cgtccggtcg tttacattca ttttttgtaa 3430981 aatattgctg acatggtttt taacggtttt ctcactgata aacaatgatt caccaatacc 3431041 gcggttgctt tttccgtctg caagcatctg cagcacttca cattcccgcc tagttaaaat 3431101 atgtaatggt ctgcggattt cagggtaaac ctcatgttga gggtgtgcag aaactccgct 3431161 tgttgcaagg cggcggaatt cgttaacgag gttgtgagta accttcggat ggaggtaaga 3431221 tccgccctca gccactactt taaccgcttc aattaatgta tcagcatcca tctctttcag 3431281 cagataacct cttgcacctg ttttcagggc atgtgttaca taattttcgt catcgtgaat 3431341 tgatagaata attactttag attcaggata cagctctaca agctgttttg tagcttccac 3431401 accatttacg tttggcatat tgatatccat gatcacaaca tcaggatgat agtgctcaac 3431461 aatacgagcc gcttcgtccc cgtcatcacc ttcggctacc acttcaaagg taggttcaaa 3431521 atccaatatc cgtttaacac cttcacgaaa taactgatgg tcgtcgataa taacaatgtt 3431581 tactttagtc acaagccacg cctccttgta ttattgttct atatactcta gcattcggtc 3431641 aatatgcctt ttggctctat tttacaaatc atagtcaaag agataacgga accttaatca 3431701 taataaatgt cccaagacct attttcgaat ctattgtcat cgttccttcc aataaatcta 3431761 ctctttcttt catgcccagc aagccgaatg atttgttttt cttctctttc gcttccttca 3431821 ggtcgaaccc tttaccgtta tcttttatca ttaaaatcac aaaatccttt gtgatctcaa 3431881 ctttgactgt aatttcttca gattcagaat gctttagcgc attagacaca gcttcctgtg 3431941 cgagcctgaa gagcgcaacc tcaaactgag gcgctagcct ctgatcctct gtttctccaa 3432001 tgcactgaaa atgtattttg accttcccgt tatattcctc ggttgtatat agatattttc 3432061 ttaaagttgg aatcaggcct aggtcatcaa gggccatcgg tcttaaatca tatataatcc 3432121 ttctcacttc gtaaagggca ttccgaacat tttggcggag atttttaatt tcttggaatc 3432181 cgtcctctgc gccccggtca cggaaaatcc gctcgattaa ttccgatctc atcataacat 3432241 tcgccagcat ttgagcgggt ccgtcatgga tttctcttga gactcttttt cgctcttctt 3432301 cctgcgcctc aataattctt aagccgaaat cctgttttgc ctgagcatca gcaagaagca 3432361 gtccaacttc gcgcaaatcc tgattcaagt agttgagcac aactgtaatt tggcttacta 3432421 atgattctga ccgctcaatg atttcctgaa gccctagcaa tctgcgctcc aaatcgtccc 3432481 gccgttcgcg caattgcttc tcacgctgct ggatcatcgt caattctacc tgcagcttat 3432541 gggctttttc ataagcattg cggatttcct cttcactgaa tctatgaaaa ttacggctga 3432601 cctcggataa acggtttctc gcatggcgag tttgcacttc aagtttatcg ccaagctcaa 3432661 tcacttcata cacctgctgt ttaatttgtt tcagttcttc gaccagctgt tcatactgct 3432721 ggcgtgactg ctccccgatt tgaaaaacct cgtccttgct cccgtcaacg gttttcagca 3432781 tcttcatcaa aatagaatcc agcactttgg aatccatctt tgttttattc ataatttccc 3432841 tccgtcacgg cgttgtcata tatttttatt ataaatgtaa ttgatctgca aattatgtcg 3432901 aattataatg aaagaatgcg tatattctag aaaaaaacat ttttatatac tatctactct 3432961 ttatgatacc aaaatacgca caaaaattct aaagactgta cgaatttgta taggcagtct 3433021 tttatgctta gcaggagggt cagctagcat gctgcacagc tattttactg tgaaagaagc 3433081 gggagaacac gagattgtta tagaaaaatc gcgttttatc tgtcatttaa gccgtgtttc 3433141 taccgaacaa gaggcacagg aatttataca gaaaataaag aaacagcact ggaatgcgac 3433201 tcataattgc tcggcttatg ttattggcga gaatgatcat atccaaaaag ccaatgatga 3433261 cggggaacca agcggtacag cgggagtgcc gatgctcgag gttttaaaaa aacgcaggct 3433321 gaaggatact tgcgccgtcg ttacacgcta cttcggaggc attaagcttg gtgctggcgg 3433381 attaattcgc gcttatggga aatcagtgtc tgaaggatta aatcatatag gtgttgtaga 3433441 acggaagctt atgcgaatca tgcatacttc tgcagattac acatggcttg gcaagattga 3433501 aaatgaatta agggagtcac aatttctgtt aaaggaaatc cattattcag aaaatgttga 3433561 attcgaaaca tacgtggaag aaaaagaaac caacgctttt tctgaatgga tgacagaact 3433621 gacaaatgga aagagtgata ttaaagaggg agagttgacg tatcttgaaa aagccgtcaa 3433681 tcacataaag gagactgaat aatggctgaa cgcgttagag tgcgtgtgcg aaaaaagaaa 3433741 aagagcaaac gtaggaaaat tttaaaaaga ataatgttat tgttcgccct tgcactattg 3433801 gtagttgtag ggcttggcgg gtataaactt tataaaacca ttaacgctgc ggatgaatcg 3433861 tacgatgccc tatcccgcgg gaataaatca aatcttcgca acgaagttgt agacatgaag 3433921 aaaaaaccat tttctatttt atttatggga atagaggatt acgcgactaa aggacaaaaa 3433981 gggagatcag actctcttat tgttgttacc ctggatccca aaaataaaac catgaaaatg 3434041 ctgagcattc cgcgtgacac acgtgtgcaa ttagctggtg acacaacggg aagcaagacg 3434101 aagatcaatg ccgcttacag caaaggcggt aaagatgaaa cagttgaaac tgttgaaaac 3434161 ttcttgcaaa tcccgatcga taaatatgtc acagttgatt ttgacggatt taaagatgtg 3434221 attaatgaag tcggcggtat tgatgttgac gtgcctttcg atttcgatga aaaaagtgat 3434281 gtagacgaaa gcaaacggat ttacttcaaa aaaggcgaga tgcatttgaa cggcgaagaa 3434341 gccttagcat atgcccggat gagaaaacag gataaacgcg gagactttgg ccgtaatgac 3434401 agacaaaaac aaatcttaaa cgcgctgatt gaccgcatgt caagtgcaag caacattgct 3434461 aaaattgata aaatcgcaga aaaagccagc gaaaacgttg aaaccaatat tcgcattact 3434521 gaaggtttag cgcttcagca gatttacagc ggctttacca gcaaaaaaat cgacacattg 3434581 agcattacag gttctgattt gtatttaggg cctaacaaca catattactt tgaacctgat 3434641 gctacaaatc tcgagaaagt cagaaaaacg cttcaagagc atttagatta tactcctgat 3434701 acaagcactg gcacttccgg taccgaagac gggactgaca gctcaagcag ttctggcagc 3434761 actggcagca ctggcacaac aactgacggg acgacgaacg gaagcagcta ttcgaatgac 3434821 agcagcacaa gctcaaacaa cagtacaacg aattcaacaa ctgattcatc ctattaaaaa 3434881 atgcccggtc cttttagagg atcgggcatt tttgcgcaga aaaaaactcc ggcacataag 3434941 ccggagtttt taattccttt tcaccagccg tttataaaac tttgtaaacg gcttaaattt 3435001 ttcattcacg agtcctgtca cttctgctat gatttgcata aaaataatca aaatgaagat 3435061 aataaacaaa gaaagccaaa ttgtggcact tttaagtaca atcgcactga tactgaaaat 3435121 aaatccaatt aaataaataa ctaagaccga catccgatgt gaaaggccaa aggccatcag 3435181 tctatggtga atatgcgact tatcaggcgc tgaaatcggc tgtttgttta atattcttct 3435241 gatgatagca aatgttgtat caaaaatcgg tacgcctaat ataataatcg ggataacgat 3435301 actgaacaat gtgacacttt tatacaggcc taataatgaa agaatcgaga tactataccc 3435361 taaaaacagt gatcccgtat ctcccataaa gatttttgcc ggatggaagt tgtaaaacaa 3435421 aaaccccagc gtgctggcaa taacgactaa tgagagtgac agaatgagca cttttccgcc 3435481 ggatagcgcc atgacagcaa tcgttgacag gccgataaca gaaagaccgg cagcaaggcc 3435541 atccaatcca tcaatcaggt taattgcgtt cgtgatgccg acaatccata ataccgtcag 3435601 cggataagcc atccatccta actcaaatcg ttctgttaaa aaaggtactg agaaaaagtc 3435661 catttttaag ccagtgctta caatcataat ggctacacct aattgaatca aaaacttaac 3435721 ttttgcactt aattgatatt tatcgtcaag aatacctaac acaataatga tgaatgctcc 3435781 gactgtaatt gccgtcatcc ttgtttctgt gtaaataccg gatgcaagca cgcctgcaac 3435841 caccccgata aatatggcca gcccgcccat gcggggcatg attttgtcat gtacttttcg 3435901 attgctgggc tggtcaactg cacctatttt aatcgcaatc ctttttacga ttggggttat 3435961 gattaaaact gtcagcagcg agacaataaa cgcaacaaca atgcgaatca tgcgttcgtc 3436021 aagcataaag aagtctcctt tggaattaaa tgaagtcttt atttatatag agaaccgttc 3436081 cttccattat accttctcct tagttattat aacaagcttc atcaaaaaga aacacgtata 3436141 atcaaaaaac gcgcatccca atttatagga ctacgcatgt ttttgaatcc ctgtatattt 3436201 cataatttgt ctaaataagc aattccaatc ttgtgtccgg gcgatgtttc ggcgcatttc 3436261 tttataggtc tcgtctccgt tttgaccgag aactttttca caagcggcta taaaatcaat 3436321 cggatgatcg ccctctacat attcgtatac atacggcttt tgcatttttg aggttgacgg 3436381 aagattagtg cctacaacag gttttcctgc cgctaaaaat tcaaatagtt tcagcggaaa 3436441 cacagcttga ttatacggtg attgtttata tggcataatg ccaatgtcga taagctccat 3436501 ataatgaggc acttcttttg gatctgccgg accggtccat atgacattgg gaagcctcag 3436561 cagctcttga aacgaaacat caccattggt ggcatccggg ccaacccata aaaatgtcca 3436621 atcaggcttt tgcagtgccg cttctttaat cattttaaaa tcgagcttcg gtttaatccc 3436681 gccaataaaa cctaacacta ttccttctct cccctgcagt atactgcgat cgggagcttg 3436741 tttatttgca gaaaacagct catactccac accgttttcc acagtatgaa ccttttctcg 3436801 tcctgcagtc agttttttgt ctacttcctt gtgaagataa tctgatgaac aggttattga 3436861 atctgctcgt tgtataattc tcagctctgc cgatttaatg acttttcgcc ggaattcaga 3436921 cagcagattt gatcggccgc tgatcggcgc agcccatagg tcactgcagt cataaatgac 3436981 ctgatcccaa gaatacagcg aagacagcag cgggaatccg ggaaacgtgt accataaaca 3437041 gcagcgttca ccgtttgcag aagcaggtgt aagctcatcg agtaatgggg agagcttatg 3437101 tctgtaaaag acatctgtat atcgtccgaa acgaaacatt tttttctgca gcaggtcttt 3437161 gacagcgaat tgcctgatgc cagaatggac ttcctgaaac tctttccctt gggcacgcgg 3437221 agccggacat acccaaataa cttccttcgt ttcctcctga gcagctaaaa attctgccag 3437281 ccggtgcctt ctgtatctca attggtcttt tccccattca gcagtggcaa cgatgacatg 3437341 aatgattgct tcttttgttt ccaccttcat caccttttct ctctgtttgc agctataatc 3437401 tttttttcac cgcgtttttt gcatattgaa caaaacacca tgttgctttc ataaaatgaa 3437461 gccgttcgat ctccctgtag acaaaccacg tttttttcgc agccttccat ttgttgctgg 3437521 aaattgaatt attgacaagc cgatattcag ccaggcattc attcattcca taggcagtaa 3437581 atcctttttt taaaagagac agccatgtgg ctaagtcctg tctcgttctg atattcggca 3437641 tttggatctg tcccgtttgc tccctgtcaa tcatcaccgt caagcagccg ataattgtat 3437701 ttttcagggc gtcatcgtac gtcaggcttt ccggcgcatg aataaattta tcgagcgggg 3437761 tcccgtcctg cgccattaag ctgtagcccg tgaaagagaa cgcacaggag cgctccatca 3437821 taaactcaag ctgcttttcc agtttgtctt ttttccattt gtcatcactg tccaaaaatg 3437881 ctacgtagcg cccttgagcg cgttccaacg ctttgttgcg agcaaccgca gctccggagt 3437941 tctcttccag atacaccaca tgaattcttt cgtctatttt ttcatactgc tgtaaaatgt 3438001 cgcgggtccc atccgttgag caatcatcca cgataatcat ttcccaatga ggatggctct 3438061 gatctaatac cgaatgaacc gtgtcttcaa tatagtcacg cgcattatag gaaggtgtaa 3438121 tgacagatac gagaggtttc caattggtca tgatcacatc tccatcgtat gattttaaaa 3438181 ggattctctg aaaaattcag gaatgacaac gaacataaag gcaatcgtaa ggccaatcat 3438241 aacgccgaga actgctttct ttttcggaga cataccgccg cctgctgtct cacttacggt 3438301 ttcggaatca gtaacacttg ccgctttcag gttaagctgt gtgtttttga gttcatataa 3438361 aaatctctct ttatccactt tggaatcctc gctcaccgac tcgccttcaa gcgcgtctat 3438421 gctgctgcgg atgacggctt ctctttctgc atacagcttt tgatcgtttt tgaggaaggt 3438481 ggaggatatg gcgtttaaga cagattccgt tctatcctta tcctcgtcac tatagcttaa 3438541 agtcagtaac gatttggatt ccgtattgat tgtaagcttc tctttgatct ctgctacatc 3438601 ttcatccttt tcatcaggaa gcgcctcctt caaaaaggag tcgctcttta atagaagcgg 3438661 aatctcttct gtgctgttat aaaccggatg atcatagctc cccacagcca aagtatcttc 3438721 agctgtatag ctcttttgat cagcgatctg tgacggcagg atataccccg ccgcacctaa 3438781 tataattggc accgctatga tccaaatgat attttttttt atgcgacggg ctattcttat 3438841 caatatatcg ttcatataag tctccctgct ttttgtagtc tgtttatctg tacatcggct 3438901 caggcatttg tctggatcgc cttaacacat tcacggcggc gatgacgagc gccataaaca 3438961 cccaatggaa aaataaattt gaaacagagc ttgggctgat acttgatacc aggaaactga 3439021 ccatagcggt aataagtcct tctgtgatca gttttgactg attttctaat tttctttcat 3439081 aaaacttgta aagcacccat atgaggtagg cataaacgga caaatatccc agcatgatga 3439141 acaaaccaaa attagcaaga atttcaacaa gccagttatg cacctctgcc acattgtcag 3439201 tatcatatac agcataatgc tcaagataat aggatacatt tcctgccccg actccgaatc 3439261 cgtatgaatc aaggaaaaaa tgccaagcgt ttttcagcag atttgcccga gccacatttg 3439321 atggaagcct gtcatgaaat gaatgcagcg tctgcggggc cagaaacagc tcccaaaact 3439381 ttgaatagat tttgctggcg aaaagaactg cgaaaagagc aattcccgcc gccgacagcc 3439441 atatagccat tctctttaaa acaggcggca atacaatgaa gatgtagaca gcaatacctg 3439501 caaaaatgcc cagaaggctg gctcttgaac cagtggcaaa aattaaatac aacgcacaga 3439561 gcgagagcac aaggccaatt gccttgatgt atccattctt aatgtttttc atcatcgtga 3439621 tgtaaaaaaa gaagctgatg gataaaaagg tcgcaaagtc attttgatta aaaaagaccg 3439681 atgtcggata atgctgcttg tactccggtc cgctgtacaa tgtggaactc gcaagatgat 3439741 ggtgggtgat atgattgtaa aaaccaatga tcatcagaaa taccgtcatc accagccaaa 3439801 tggcataaac aatcatcagc cgctccattt tttgcacgta catgacaata agataaatga 3439861 agaagatccc cattgccaat aaggctaaat acttgaggcc aactgttacc gacttggccc 3439921 acagcagaga aacaaggcca tatataaacc aaaaggcgaa aaagagtaaa atccctttta 3439981 cttgcagccc atgccatctt tcaatatggg ttcgattccg aaccatgccg aaaatatgaa 3440041 ggcaacccgc tgcaatgagc agaagccggt aaaggaacaa actgaaaaat ccaagatgaa 3440101 tggcaaaaaa tgcattattt aaaaaagtgc aggcgatcaa aatatagatt acagccataa 3440161 agagccgttc ttttgttgta aatgcggttg caagcgtcag taaaaacagg ccaattgcca 3440221 acaccgcaag cacagcagcc atctgcatga aacctatatc tttatggatg gctcccagca 3440281 ataggacgac tccaaatata gcagcggcca gtaacgctag cgtatggacc gctgatcgtt 3440341 tgatactcac atgtttaacc cctttcctga tgtttcagga gccggcggcc gagcctagca 3440401 gccggcagct tcaaccaagt aacacttttt ctttttataa attgacgctt cccaagtctt 3440461 tagccaattc ttcaagcggc aagcccggaa aatacttgtc agagggttcc gttccccgaa 3440521 cagcgggacg gccgatagag tgataaatgt atccggctgc ctgcatctct tcaagtgaaa 3440581 ataaatttct gccgtcaatg atgactggct gttttaagag ggttttcact tttacaagct 3440641 ccatttcttt cacttccggc caatccgtta aaatcaggca tgcatcagtg tcttccatcg 3440701 cagcatacac atctgtgtaa tactcgacct gttcgccaag gatcgctgaa gcttcaggaa 3440761 tagcaatcgg atcgtatgct tttacatggg cgcccagctg ctgcagcatt gggataatat 3440821 caagcgctgg agcggatctc acatcgttcg tattcggttt gaaggctaat cccaggactg 3440881 aaatggttct ccctttgacg cttcccataa cagtcaaaag tttatctaca atatgaacac 3440941 gctgcttttc gttcgtttca atgacagctt cgatgagctt gaatggatag cctgccgatt 3441001 ttgcgatttg aagcagcgcg gttgtatcct ttggaaaaca tgaaccgccg aatccaatac 3441061 cagctttaag gaactttctg ccgatacggc tgtcaagacc aacaccatca gcaacttttg 3441121 aaacgtctgc gccgactcgc tcacaaatgt ttgcgatatc gttgataaag gaaatctttg 3441181 tcgccagaaa tgcattcgcg gcgtatttaa tcatttctgc actttctagg tttgttttaa 3441241 tgacaggagc atggaatggc tgatgaagtt cctcaatgat ggcagcggct ttatgacttg 3441301 ttgaaccaat cacggcacgc tccatattca tcgtgtcatg aatcgctgac ccttcccgaa 3441361 ggaattcagg gttagataca acatcaaatg agtatctccc ctttgaggct ttttgaacga 3441421 tagattgcac cagtttccct gttccaaccg ggactgtgct tttatttacg atcactttgt 3441481 agccgttaag atgctcaccg attgttttcg ccgccgcttt gacgtacgtt aaatcagctt 3441541 cacctgtttt ggacataggc gttccgactg caatataaat aatatctgag gcccgaatgg 3441601 cagacgggat atcgttcgta aaggtcaggc gctgatccag cacatttttt tcaactaagt 3441661 ctgcaagccc tggttcatag attgggatta ccccattttt caggcttctg atttttgatt 3441721 catcgatatc acagcaaaca actttattgc cgatctccgc aaagcaagtg cctgatacga 3441781 gtcctacata acctgttcca atgacagcta tttttttcac agcgctcaac cctctcctgt 3441841 aaaatgatct tccaatttat aatggtcgca gtgtcttacg attaaacgga cgttttcgtg 3441901 accgtctgat actgatgatg caaggccttg gcgttttttc ctgcgtcaaa ttgagcctgc 3441961 acggtttcat acaagtcatc tgctacttcc ggcttccata tttgctcatg ttcgtaccga 3442021 gtgatcgctt ccgccaaggc ttgagcggat ttcggtttaa tcagcagatg ttggtgcttt 3442081 ccgaataaag acgacactcc gccaacatcc gtacaaataa caggaaccct tagcgccagc 3442141 gcctcaatca caacagtcgg catcccctca ctgtaagaag gaagtacgaa tagatctgcc 3442201 gcaagtaaat agtctcttac ctgatgattc gggacttggc ctgtgacgat atgccccttc 3442261 tgcgtcagcg tcgattttgc gggaccatcc ccgacaaaga ctgccttagg agagtcctgc 3442321 agcgattcga tcgcttcaga cagttcaaaa atgcctttct ctctgaccag ccggccgaca 3442381 tagacagcca gacgctgatc gagcgggagt ccgagtcttt ttctgatttc ctctttcgtc 3442441 tcctcattcc cctgaaaacg gctgagctgt atgccgattg gcaaaaccga gctgtcaaag 3442501 cccgaaagct ttttggcttc ttcctgaagc ttgtggctga ctgctaaaac aactgacgca 3442561 gaacctacgg cacgcttgaa ggctttaaac gcacctttgc tgtaatgcgg atagacattc 3442621 acatcactgc catgcaaggt caggacataa ggaatttgcg ctgactctga cacgactgcc 3442681 gcagccccgc ccgatggcat ggcaaaatgc gcatggatca gatccggata taggtcgcgc 3442741 tgtttcattg tttttaaaac ggctgatgcg attctccgat gaggctgcgc ccacttcagc 3442801 tggccgggaa ctgcccgata gaaaggccgg taaaccggta tcccctttct aatctcatac 3442861 tccggtctga catccttttt tcgatatgtc tttttcagca tgcggacagg tgctgaatga 3442921 aaaggccgtg ggcatatcac agtgatatca agcccgagtt tttgcagctc ttgcacctgt 3442981 gtctcatgaa acacaccctc tccgggtttc atactgctcg gatatacgct tgtgatccac 3443041 aaaatcttca tgacaaacgt ccttttctta gtagtttgct tttcgtttga gggtacgctt 3443101 ttaccaaaag aaagagatag cacagcgccc cagccgcaac tgaaatggcc agccgcattt 3443161 ctgcctgcat actgaagtgt tcggtactga ggcttacacc aaacgcgatg atgcccatcg 3443221 ccgcagtaat cagaaatggc ttcataatcg actggaaata agctgaaagg ttaagcttga 3443281 tgacatatgc caaaagccag cgcccaatca ggaaattaac aacgctgata atggcataca 3443341 cccatgcgac tgtcagcagg cttcccgtct gtacagctgc aaacagtgat aatccgtaca 3443401 gcagcagcac gccggaatcc caataaaacg ctaagtcagc tcttccttta gccagcaaca 3443461 cagatccatt tggattcatg agcactctta gtattccgac aatcgcaaga acatttagga 3443521 tcggaacagc agcaagccat ttttctccga aaaccgctgt gataaaggcg tctgacacag 3443581 acacgagccc gattaacagc ggaaacgaaa caagcgccag catttttgtc atattcagaa 3443641 agccttctct gatcacgctg ttttcatatt tgttttttgc gaaaataggg aatgccaccc 3443701 gtgtgacaat cggattgatc ttcaaaaccg gaatggtgac aatctgataa gcgaggttat 3443761 aaatccccaa tgcttcagca ccaataaacc ggccgatcaa aatcatgtcg atatttgctc 3443821 ccagcctgtt cacaagacgg gatgaaagct gaaaggctcc aaaagaaaag aaatccttca 3443881 tgcctctcaa atcaaaaaca aaagcaggat gccacttttt tcggtataca gcccaatata 3443941 aaatcccttt actggactgc agcaggactt gagaaatcac gtacgccaaa atcgcatcca 3444001 tcataaaaac cgctatcgct aaatatccga atgacaatac atttgaaaaa atctctattt 3444061 tgcttaacgt attaaaatgc agctgctttt gcagcatata ctgatattgc tgtccaattg 3444121 gcgcgatcaa aaacataatc gccagaatcc gaaccagaaa caccagctct tctctttgat 3444181 aaaatcccgc aatgacagga ctgctcacat ataaaagaac aaacagcaaa acgcccgtca 3444241 taatgttaag ccaatacaat gttgacagct ggcgctccgt cgcgtcgtct ctctgaatta 3444301 atgctgcgcc aaaacccata tcgagcacaa tctgggcgaa aactgtaacc gttgtgatca 3444361 tgccgacaag cccaaattct gttaaggtca tcatatttcc aagcagggca aactgaacaa 3444421 tttgtatgat tgtaatacac atggttgaaa tacttgtcca ctttgcaccg ctcatgattt 3444481 gttttgtaat acttggcatc atattcccta cttcttttta agctcagatt gatggtgaat 3444541 aatggaatcc cgttttatct tgcaccatca cccgtccaaa ctactttaca agtttttaac 3444601 ataattttta attctaaagt gaaagtcaga ttgcgaatgt aatataaatc aaatatcagc 3444661 ttttccttcg gcgtcatatc gtaaccgccg ttcacctgag cccagacgct gtgtaaagcc 3444721 tggaatctca ttctggaatt tttccgtaaa tacgggccgt tccggacgag ggccaatcat 3444781 actcatatcg cctttcagca cattaaacag ctgaggaagc tcgtcaattc tcgttcttct 3444841 gataaaagct ccgatccttg tcacccgcgg atcttgcttc tgtgcccaaa ccgccccaga 3444901 cttctcggca tctattttca tggaacgaag cttataaagc ttaaatggct tcccgccttt 3444961 ccctacgcgt tcctgcgtat aaatggcagg ccccggcgtc tccaaacaaa tcaaaattga 3445021 aaataccgca atcattggca gcgcaatcgc caatccaatg agcgcaaacc aaatatccat 3445081 tacgcgcttt attgccaaat aacgagccgt cttttcagat aatgtaaaag aatgtatttg 3445141 ttgaactgag aattcacgac tcacattcat gcttttctct gcactcactg acacacacct 3445201 cacgatttgt ttgggatgtt atgatgacct atgccagtca gtttagcaga cggatgttaa 3445261 ttggatgtaa atggtatgtt aagaagtgtg aattacgtgt tttttctgat aaatgttgtt 3445321 aatactcttt tactatttta tatacaagtc ctatttgttt taatcatttc atataaaaaa 3445381 gagacaaatc tgtgattaga tttgtctctt tcgattatct gtaataagat actgtgccgt 3445441 catgaatagc ttgtgcagct ttatctttat aaaccgcttg cttcaattta cttgcatctg 3445501 atgcattagt gataaaggca gtttcaacta aaacactcgg cattttagaa tatttaataa 3445561 catagaaagc agctgttttt actccccggt ctctcgttcc aagattagcc gctaactttg 3445621 gttgaatttg ttcagccagt ctcttgctat ttgcagcttg atatgttgta tcgtagtacg 3445681 tctcacttcc atttggtgat gagctatcat tagcatttgc atgtatactg agaaataaat 3445741 ctgcttgtgc agaagctgct ttatttactc tctcctgtaa agaataaaaa gtatcattag 3445801 atcttgacag tactggaaga gcacctgaag catttagctt tgtattgact cttttcgcta 3445861 tatcaaggtt gacttctttc tcaaggagtc cattgccgat tgctcctgaa tcttgatcac 3445921 cgtgacccgg atcaataaag attgtttcac ctacaactgg attctttagc tgattagcaa 3445981 cctttgtgct tacggcagga gtgtttccga taatcataaa gtttgacatg tttttacttc 3446041 caataatttt acgggctcct gtagataaat tttcaccatt tgtaagaata agagattgct 3446101 tcttcttagc tgccagtgta gctcctgcaa tagagtcagg gtagctgaat ccattgctta 3446161 catatacggt gcttgttgat aaattaagtt tttgtacgat atttgcagca agctcatatc 3446221 tgtttgaacc gctaattctt gtaggagaag gtaacttgtt gtataccgta ttgctgatac 3446281 ttccagtgcc tcctacaaca acggtactcg aaattccctt atcttttatc acagacgtag 3446341 tcgcactatt tatagatgtt ttatttgtaa aaagaattgg atacccgttt ttcgctgcat 3446401 aagggatgac ggccggagcg tctgcatata agaagccgtt caaaataaca gcttttgaag 3446461 tcgcacccat cgcttttgcc acccgtgcag ccgtatcata acggttgctt cctgcaattc 3446521 gtttaatact tatccccaag cttttaatct ggttagcagt gttagaagaa acagcaggtg 3446581 ttccgcctac aataattaca tttttagtct gcatctcttt caatcttgtt ttcgtttcat 3446641 atgaaagctt atcagaatta gtgtaaagca atggcgcatt cttctggtaa gcaagaggtg 3446701 ctgctgaaat agcatctgca taggaactcc caccaacaat tacagctgta cttgctgttg 3446761 aatacatttg ctttgatatt tgtacagcag tgccgtatct attgcttccc ccaactcttt 3446821 tcactgagtt atcggccaaa gctgttggca caaaaagtat gagccccaga aaacacattg 3446881 ttaggacttt tatataagaa cgcaattgat ttcctcctta aatggcgtta tatcctaaaa 3446941 taatcaataa cttgtcagag ttgtacctgg atagtaaaat ttcaaaattg aactatatga 3447001 atctccagct tctgctcttg cttttgctcc atattgactc attccgatcc cgtgaccata 3447061 tcctttaccg ctgattgtgt actttgaagt atcttttttt acagtcacat aagtactttt 3447121 aaatacagtc gctccaatca ttgttcttaa ctcacttgtt ggtacactaa tggttgtaat 3447181 tttgctcaag ttataggagc cagtactgct tttaacaaaa tacttcactt tcatcgatgc 3447241 tgtttttgca cgctgccctt gtgtcgttcc actaaagctt aaatcgtcaa tacttgcaat 3447301 tttgacagaa tcagcgcttg tttctttatt tttcaagatc cagttcttaa ctccggaaag 3447361 tcttgcagaa tcagtttcag tcgctgaaga ccaccaagaa gaaggcttcg ttaagtccaa 3447421 agatttcgta tctagctgtt gttttgacaa agtaagcgtc cagcctattt gaggatcctt 3447481 tgtatctttt tttgcaatca agtaaggtac acttgacgac cacacttcat tactagcttc 3447541 tgtgtaacca ccattactgg aagaataagc tgcagttata agagatccat tatatttcag 3447601 aactttcccc ttcgtttgct ctaccgcttt attggtattc gaattccaac tgtagccacc 3447661 ataaacttga aaagcggttg tatcaggtac agtagttcct gtttttgtta ttgagtaggt 3447721 tcttgcagcg acagtctgtg ctttaagagc ctcaagtgac cagctagcag gcatttcatt 3447781 cggaattact ccttttaagt aatcctcaaa tggaatattc tcatttaccg gtcggatata 3447841 tttagtagac tcaatagaga aattaaccgt gccaagatac tgctttccat caagactaat 3447901 tctgtttgaa gtagaatagt tttctggttt aattcttagg gagtttccgt aagttttgat 3447961 gttttcaagg tttaattttc cgctgttgat ttttagatta taggtgccac cgtcagctaa 3448021 ataaaattca tcagcaagtg aattctcaac ttcagcagaa attgaactgg tacttccaat 3448081 aaagtcgtat gcatatgtgg ctttatcttt cgttatactt ttagccgcag ccggaacgct 3448141 atcttgttta acaaataaaa tttggctgtt tttcttcgag gcaagcgaag cgcctatcaa 3448201 tacgtctgca tattttgtcc cgttcgtcat tacgacttta tcagccttca actttagttg 3448261 cttaattata tttgccgtaa gttcatatct ggttgatcca ggaatccttt gcacagttga 3448321 agttttttta atttggtttt ctacactatc actgacgcta aatgaactgc ctataatgat 3448381 gacttgtttt ggcaaatcat aatccggaag cttgtctttc tctgtaagca aaatagggta 3448441 tccgtgtgct gctgcatatg gagcaatggc taaagcgtct tgaaatactc ttccggttac 3448501 aacgatcgct ttatcatagc tgcccatttg ctttgcaata ttttctgata agacatatct 3448561 attttttccg cttatccttt tcacagcgcc atatgatttc agcttgtttt ctacgtcttt 3448621 tgaaatgctt cgcgctcccc caatgattaa aatattatca gggttaaact tagcaatttg 3448681 tctttcagta gtttttgtta acgtgtcagg ctgagtaaat aaaactggtg cgttcagttt 3448741 tttcgccaat ggaataacag gcaatgcatc aataaaaata tctcggttca ccaatatcac 3448801 tgtattagga tttttccact ggctgttgga tgcaagagtc gcagtttcgt atcgtgaagc 3448861 gcctgcaaaa cgatccgtaa cagcaacatt atctccagtt actttataaa atcctgttgg 3448921 cgatagactg atgctagatt tatttccaat ataatttaac aatttaactg agatgtttga 3448981 gtctgctgca aaagaaactg atggaatcaa taataagatt gcagcaagtg aacacactat 3449041 caattgtttg caagatttca aaatttcagg ttcctcccta tatcttagtt ggcacgttca 3449101 atatctttta acagaagctg accctcatca tttttttcat atgtaatcgt gaccttatct 3449161 ccactgttaa acttatcaag atcacttgtc gattcttcag tgatatcaag actaaccggc 3449221 tcattatcta ctgttacttc tattgtatga gtatcagcta accctacata agtaccttct 3449281 tttgtttcaa tgttactgtc tggcgataca tcttcacctt gactcttttg actattaacc 3449341 ccgcaacccg aaagaagcaa tataaagaac agtaaagcaa taaatttttt catttttttc 3449401 acctcattat attttatcgt caacctattt tatattttaa agaaaaatta agaaacaatg 3449461 aaactttttt ttataaaaaa cgactatttt aggatttcat tcttgtatta aatagagttg 3449521 tatttattgg aaatttaact cataatgaaa gtaatttaac agacgaggtg caaaggatga 3449581 gaaacgaacg cagaaaaaag aaaaaaactt tattactgac aattttaacg ataatcggac 3449641 ttcttgtact cggaactggc ggctatgcat actacttatg gcataaagca gcttcaaccg 3449701 tggcaagtat tcatgaaagc attgataaat ctaaaaagag ggataaagag gtcagtatca 3449761 ataaaaaaga tcctttttcc gtcttaatca tgggtgtgga tgaacgcgac ggcgataagg 3449821 gccgtgccga tacgctcatt tatatgaccg ttaacccaaa aacgaataca accgacatgg 3449881 tcagcattcc gcgtgacacg tatacaaaaa ttatcggaaa aggcacaatg gataaaatca 3449941 accattcata cgctttcggc ggcacacaga tgacggtaga cactgttgag aacttcctcg 3450001 atgttccggt tgattatttt gtgaaagtga acatggaaag ctttagagac gttgttgata 3450061 cacttggcgg cattacagtt aacagcacat tcgcgttcag ttatgacggt tattcgttcg 3450121 gcaaaggaga aatcacgctg aacggaaaag aagcgctcgc ttatacccgg atgagaaaag 3450181 aagatccgag aggcgacttc ggacgccagg accgccagcg ccaagtcatc caaggtatta 3450241 ttaataaagg cgctaatatt tcttccatca cgaaattcgg agatatgttt aaagttgttg 3450301 aaaataatgt gaaaacgaac ttgaccttcg ataacatgtg ggatatccag tccgattaca 3450361 aaggtgcgcg gaaacatatt aaacagcacg aactaaaagg tacaggcacg aaaatcaatg 3450421 gaatttacta ctaccaagct gatgaaagcg ccctttccga tattacaaaa gagctgaagg 3450481 aaagcctcga aaagtaaaac aaaaagaagc ttcgcacaat gtgcaaagct tcttttttat 3450541 ttgcctgtaa atgaatccgg ttgttctttt cgatacccgt aatgaaacag caattcttcc 3450601 acaatccggc gggaagcctc tccatctcca tacggattag aagcctggga cattttcttg 3450661 tactcatcag gatcagttaa cagctgtttt gcaagctgat aaatgttttc ctcatccgta 3450721 cctgcaagtt tcagcgttcc cgcttccact ccttcaggcc gttccgtcgt atcacgcaga 3450781 acaagaaccg gtttcccgag agatggggct tcctcctgca cgccgcccga atcggtcaat 3450841 ataaaatgcg atttcgctgc aaagttatgg aaatcgatca cctctaaagg ttcaatcaga 3450901 tgcactctgt cagaatcacc aaaatgctta tgagccgctt cccggacaac aggattcagg 3450961 tgcacagggt aaacgacttg tacatcttca aattccccta caattctgcg gatggcctta 3451021 aacatgtttt ccattggctc acccaaattt tcccggcggt gagcggtcaa gagaatcatt 3451081 ttatcctcac ccacctgatc gagaacagga tgtgagtaac catccctaac cgttgtgttg 3451141 agtgcgtcaa tcgctgtatt gcccgttaca aaaatagagt cggccttttt gttttctttt 3451201 aataaattgt ctttcgcctg gcctgtcgga gcaaaatgca aatcagcaat cgcccctgtc 3451261 atctgtcgat tgagctcttc cggaaacggg gaatacttat tccctgtacg gagccccgcc 3451321 tccacatgac cgacagcaat ttgatggtaa aaagcggcta ggcttccggc aaacgtcgtc 3451381 gtcgtatcac catggacaag cacaatatcg ggtttgatat ctttaaacaa ctcatccaat 3451441 cttacaagtg cgttagacgt aatctctgcc agtgtctgcc gctccttcat aatgttcaaa 3451501 tcgaagtcag gcttgatgtg aaacgcatct aacacctgat cgagcatctg tctgtgctgt 3451561 gcagttaccg ttacatagga atctatttca ggatattttt tcaattcaag cacaagcggt 3451621 gccatcttga tcgcttcagg cctggtcccg aaaacggtca tcacttttag ttttttcata 3451681 tttgtcacct ggttttctgc tatagtaaat aaattcatac tacatattct acatgaaaat 3451741 gcatcatttt aaatcatttc attcttgatt caaataaaat gatataagtt ttaatattaa 3451801 ggataaagct tgtttaaaaa tggtttatcc gatatcataa aaatgtgtaa aaacatattg 3451861 aaaagggtaa atagagaata gtttaaccat aaattttttc gatcataagg aaggtgcctt 3451921 ttaaatgaaa aaagtacgta aagccataat tccagcagca ggcttaggaa cacgttttct 3451981 tccggctacg aaagcaatgc cgaaagaaat gcttcctatc gttgataaac ctaccattca 3452041 atacataatt gaagaagctg ttgaagccgg tattgaagat attattatcg taacaggaaa 3452101 aagcaagcgt gcgattgagg atcattttga ttactctcct gagcttgaaa gaaacctaga 3452161 agaaaaagga aaaactgagc tgcttgaaaa agtgaaaaag gcttctaacc tggctgacat 3452221 tcactatatc cgccaaaaag aacctaaagg tctcggacat gctgtctggt gcgcacgcaa 3452281 ctttatcggc gatgagccgt ttgcggtact gcttggtgac gatattgttc aggctgaaac 3452341 tccagggttg cgccaattaa tggatgaata tgaaaaaaca ctttcttcta ttatcggtgt 3452401 tcagcaggtg cccgaagaag aaacacaccg ctacggcatt attgacccgc tgacaagtga 3452461 aggccgccgt tatcaggtga aaaacttcgt tgaaaaaccg cctaaaggca cagcaccttc 3452521 taatcttgcc atcttaggcc gttacgtatt cacgcctgag atcttcatgt atttagaaga 3452581 gcagcaggtt ggcgccggcg gagaaattca gctcacagac gccattcaaa agctgaatga 3452641 aattcaaaga gtgtttgctt acgattttga aggcaagcgt tatgatgttg gtgaaaagct 3452701 cggctttatc acaacaactc ttgaatttgc gatgcaggat aaagagcttc gcgatcagct 3452761 cgttccattt atggaaggtt tactaaacaa agaagaaatc taaacaaaaa ggctattgga 3452821 cattcatcca atagcctttt tttatttcaa catcaaagtc aatgtatgct cttcattatc 3452881 aactgcgaag acctgatcaa cggcctgccg caaaaattaa taatcccaga caaacacact 3452941 gattgtagag ttaaacaaac taaatgaaaa cataaataca aacatgcaga ttaaatagta 3453001 aatatcttgt attcaatgca agctaagtaa acaccacttg ctaaaagaac aatgactaaa 3453061 caaccagcat tacaaaataa ttaaataaat ttgaagcaat tacaacagaa ggcagtgaac 3453121 tgtcggaaag ttcattttgg ctaccatatt aatcccttta actacgctgt tggatttatc 3453181 aagaattgtc gggctaatag aaaaccacgg aatcaaacca gccagcattc aaacgataaa 3453241 aggcacttct ccgatacctg ttatgaccag cttactgttg cgcatcccaa atacaaacca 3453301 gtacgccatc attagaataa ggggatttaa aacctgccat aatacaccaa aataattgat 3453361 tttttggatc tttcggttaa agaaatttaa aagtaccagt gaatattgta acaaatgttg 3453421 agtttttttc acttttaaaa agtaaagaga agtctcgcag aacttctccc aacatttgaa 3453481 gtgtcaatat aaaacaaacc aacctcattt agcaacttta ttattatcta attccaaaat 3453541 agcattataa atacgattcc tattattttt atcagtatat gcaaaaaagt tatctactct 3453601 ttttctatac ttatcttcca tacgactatt gtttttcata taatagataa ctttatccac 3453661 taagctatta tgattttcta atacatcacc aaaccccatt tttttataat cataataatc 3453721 aagtttaaaa tggtatgact tttcgtattg ataataaata acaggttttt tctcatatgc 3453781 aaaatcaaac gcaacagatg aaaaatcagt aatcattata ttagaagaat taaatagcat 3453841 ttgatagctg ctgttatagt cggcaaactc cacataatca tgcttttcaa agtctacaat 3453901 ctgttgctga atatctgggt gaggaaaaaa agttatttta taattatttt tcttagcaaa 3453961 ttcgattagc cgttcatcat taatcaaagc attataccta gaaaaatatt cactatcttt 3454021 aaatttcggg ttgtacggtc ttactccttt tgcctgatct ttcggtaata caatatcttt 3454081 tctccaagtc ggcattatta gaagttgctt ttctccctca ctcttcttaa gattatcgta 3454141 tctcggaaat ccacccaaca aaatattctc ttttttatag ttgtaattcc ctttcacaat 3454201 agaccgatat tcaggtttgg cagaagtgac taataatttg atattcttgt tgtatttgtt 3454261 taaccattca gaatgatctg ccattgttat tccgtgctgt aaaaagataa actcaaagtt 3454321 aaataaatct ctaaaataaa tctccatatt aaaaaatgga tttacaaccc atatatctgc 3454381 atgtgtcgat attactttgg aagaggataa ggttaaaatt ttatgtctaa aagatctgta 3454441 tggtatgacc tttccatatt ttttgattct gtcgtaatcc ttgctatctt tttttattat 3454501 aaagtatttt tttaccccat cattcttgtt gattgcatat ttaaagaggt gctcggcatt 3454561 atcatcagct ttgtcttgtc tgtctatgaa taaccatact ggttttctat taaaaatagt 3454621 gaaaacatgg tgtaccattc ttgccatcag tgccttctta atcgctgatt ttcgtttttt 3454681 tgatttttcc cctgatttat gtagggattt taagaaacga aactctttta taaatctatt 3454741 tttaaaattg ttttttttga acattaattt tttataatta taataaaaaa tataatcttt 3454801 tttagccaca taagtattat ataaatcgtt tgacaaacct gaatacttga aaaaacgaag 3454861 ttttgtcaac ttcctttttt tacccttagt tataaaaaac tcaatatgat gattatctgc 3454921 tagatgacct ttgggaatat ctattgaaaa accgggatat ttttttatta cttctcctaa 3454981 acttatataa tcattatgct gtctttttat attctttgct tttatttttg tttcgccaat 3455041 tttagcataa aacttaaaac ctttagaatt aaacagcgag ctccaaaagc cttctatgtg 3455101 aatggaatcc tcattttctt ctaaaatttc aatagttaaa gtttgatccg ataatttcga 3455161 aacaatttta ccttctctgt ataaataata atcctgttca gtttctcttt catatacata 3455221 cctactataa ttttcaccgt gctttatttt taaagcatga tataaataga aatggctgac 3455281 actttttgtt tcaatgatga catcgtcgtc aatatacgac aatacttctc gaatcaatgt 3455341 taaaaattca ctgtattcat tttcgtctaa aggtgtttca ctgatatcct taatcaataa 3455401 tttccacttc aaatcatgca taaccatata ttgaagaaat aaaggtattt tctgttcatg 3455461 attttttata atatcgatta aattctttga gaaagtgata agtgaatggt taaaccaatt 3455521 cttatttgct ttagcagtct gcatggcaga tgatccatct tctctaactc tataatggta 3455581 ttttgcctct ttaaccagac catacttttt cttttgcgat atgattaaat taactagttt 3455641 ggcatcttca cctattttac aattttcatc aaacctgata tttttcaagg catctttttt 3455701 tataaatgta gaacaacaat gagttaatat atgatgcggt tctttttcta catccaaaat 3455761 tcttgtagaa gaaaacttat tatttagatt atgttctcca gttcttcctt ctgcaaaaaa 3455821 aatagggatt gctacaatat caatttcatt cttatgttcg tcaaagaagt ttaaaacatt 3455881 ttcgaatgtt ccttctgaaa ctaaatcatc cggatccaaa aattgaatat atctaccttc 3455941 agcatacttt aaaccataat ttcgagcact gctcactccg ccattctgtt tctttgcata 3456001 gacaatgtta ttgggatatt tctgagcata ttctttacaa atgatttcac ttttatcggg 3456061 gctatcatca ttcaccagta ttaactgaat attctcaaaa ccaatagttt ggttaatgat 3456121 actttctata gcttcagtga gatacaactc aacattataa atcggcatta taacactgaa 3456181 atcatagtta aaactttttt cgttcataaa agattactcc taacataatg tttatatgaa 3456241 taagaattcg ggtaaataaa attaagaaac aagagagtac taatttttgc aaaacaattt 3456301 taatttagta aaatgtatga aaagcattcc ttaccttttt ttaaaaaccc ttgtaagcaa 3456361 acttttaaaa atgttcacat ggttaagttc taaagaatca tttggtgttt ttagtacaaa 3456421 gtcaaatgca aaggcccaaa tcggtatttc gacaacaaaa ccagcatatc taaaatctct 3456481 taatttatat ccccatactt caattgtttt tttcagttct tttcgtttgc atttttttaa 3456541 tcttttaaaa tattttatat atattctgtc attttctttc atctcataat actggttaat 3456601 aaagtgccct gttaattcaa gtctaagccc ttttattttt gccgaagtaa cagtacatga 3456661 actatgcagt actctttctt tttttatatt ttcaagagct tctgtatttt cttttaataa 3456721 gtgaaacata aattctttat agtacatcgg catatcttgt tcttttataa attgcgggtc 3456781 aataaatttt aaaactttaa taaaatcatc aacaaaaact ctttgttctt gttgatctaa 3456841 aacagactta taaacatctc tatagttcgg atataaaaac agttttatat gatatacaat 3456901 taaaaattgc aaataaggca aaactatatc atatttgttg aatgaatcca tcaacaaagt 3456961 catgtaacat tcattcaaca aatatgtgta cctttttttg ttaaaccatg aacgatcaac 3457021 taaagaatcc tgttctttcc gttttctata aaaatacttt ccttctgcaa ctgctccgta 3457081 tcttttttct ttcagtaata actggttaaa aaagatagcg tcttcccaaa actttataga 3457141 ttcatcaaaa aggacggtac tagttagtgt atgtcttctg taaaaagtgc cgccaatata 3457201 aaaatgaata gctttataat cgttgagaat atttataact cttgttcctt tttcaaatct 3457261 attatttaat ttatgtcccc cttctttttc acctgtgtaa taaacaggta ataccgcaat 3457321 atttacatgt tcggaatcac aaaaaaaatc ataaacactt tgcagcgcat tttgagagaa 3457381 tgcatcgtca gaatcaagaa aaccaataaa tttagatctt tcgcttacat ttgataatcc 3457441 acaatttctt gcagcagaag gtccagagtt ttcaattttc atgattttaa tattattagg 3457501 atatagattt ttaaaggatt cacaaatttg aggactgctg tcaacactac catcatctat 3457561 taatatcagt tctatatttt ccttaaatcc aattgactgg ttaaggacac tctctattga 3457621 atatcttaaa taattttcag aattatatat tggtataatt atagaaaaca tgtttgtacc 3457681 tctttattta gaagttaaag gatcgtttca attactcttt tagaagcctt gcctcttcta 3457741 aattacaaaa tttattataa aaatcctcat agttatgatc tatataagga ttatgtaaca 3457801 actcttttac cgtatctata agttcttcac ttgtttgaag caagtttcct ggcgtttttt 3457861 gctgaaaatt aaagtaaaaa cctctgatac agtctctata agccgggaga tcatacacaa 3457921 aaaatacaag gtttttttaa aaattcatat tatcaaaaaa gacagaagaa taatccataa 3457981 tcaataaatc actaattaaa tataaatctc gaatatcttt atttaaagaa acatcgttca 3458041 caaaatattt atatttccct aattaaattg ttctgaaact ggataatacc attcttacaa 3458101 gaataaccat agagtctcca aggttccctc ttcatttcct ctaatcaaat taaagttaaa 3458161 tttatactgg ccagctttct taaaattcat tatcccgcaa agttggtgca tataaaatta 3458221 tttttcttta attccttatt tgataatgta gaattggtag gggattgtag ctaaactgtt 3458281 tccagaatag ctttcaaata aaattaattt attgtttctt ggcagaagga caaaaatttt 3458341 aaacaaaact gaataaactc taactagtaa acttctgcaa ttggttataa taaaaatttc 3458401 atcagtgaac tccttaaaga gtgaagatta atatttacgc aaacaagaaa aaaagaagca 3458461 actgaattta cttcaagcct cttttagtta gtgcttctat aaactagcca tatcttttct 3458521 gatttgggta gttgaaatgc ctgctattct tgtaaggtaa atggcctcat agtattcctt 3458581 tgtagacaat cgtacgatta agtaatccca ggttcttttg ctctttccag tagcttcata 3458641 tgtccatagt gaaataaatc aaacattccg tacgtatcac tttcttcatt agataacatc 3458701 accttccaac cttttccaac ttagaaaaaa caaaaatcct taactgattg tttatcattt 3458761 cgacatattt tttacgttcc attaataata aacaataata gcatatgttc ctataaaagt 3458821 taaggctctt taaaaatgta aatcatcagc actttttgac aatatcgttg cattgatgtg 3458881 tattttttac agatctgata tcttatctat actcattaca acaagttttc tattccggaa 3458941 gagtcaattc tttttgtcgc gttttcaagt gtaatgattt tctttctgct gcgtcattta 3459001 ttttgtacgc cctcctcata ttacttcatc gtcaaaacgt gaaggaattg taatacgtag 3459061 ttcctaaaaa ttttcgtggt aaaatttagt gaagtcttta tcaggctaag ggactttatc 3459121 taaactacga attacatatg gagatatata gatgaaaagg agggttgata tgatataaac 3459181 gaaaatcaat tagataaagg aaaaactgaa cacttctgaa aaaagtgata agtttctttc 3459241 actatatcct ccaaaaagaa cctaaaggtc ttggacatgc tgtctggttc gcgcctaact 3459301 ttatcggcga tgagccgttt gcgtttctgc ttggagacga tattgttcag gctgacacac 3459361 cagggttgcg ccaattaacg gatgaatatg aaagaacact ttcttctatt atcggtgttc 3459421 agcaagtgcc tgaagatgaa acacactgtt atggcatcat cgccccgctg acaagtgaag 3459481 gccgccgtta tcaggtgaaa aacttcattg aaaaaccgcc taaagacaca gcaccttcta 3459541 atcttgccat cttaggccgt tacgtattca cgcctgagat tttcatgtat ttagaggagc 3459601 agcaggttgg cgccggcgga gaaattcagc ttacagacgc cattcaaaaa ctgaatgaaa 3459661 ttcaaagagt gtttgcttac gattttgaag gcaagcgtta tgatgttggt gaaaagctcg 3459721 gcttcatcac aacaactctt gaatttgcga tgcaggataa agagcttcgc gatcagctcg 3459781 ttccatttat ggaaggttta ctaaacaaag aagaaatcta aacaaaaagg ctattggaca 3459841 ttcatccaat agcctttttt tatttcaaca tcaaagtcag tgtatgctct tcattatcaa 3459901 ctgcaaaaac ctgatcatct gtattcacaa gaaaacgctt cttgctgctg tcatacaata 3459961 catcgctatc acttaaggat agtgacgccg ggttgatagg agaaatgtta tgaaaaataa 3460021 gctctgttgc tttatcattc tccagtacat aactgatttt ttcataatca aaattcagcg 3460081 tttttctgcc gtcagcctta tttccttcag tataaccatt caatttcgat tgaatgctgg 3460141 tgctgctgtc tcctaggaat ttcagaaagt attcatagga agatgctgcg ttttgcgaga 3460201 cataagacgt aaatgcagtg gcatgcaatt cagcgtgttt catgttagtt gcaacagcgc 3460261 tctgtttcac ataataagag tgcccgtcaa actttatttt cgctgcttgt ttgccttttg 3460321 cagctaccgt tacttttgta ccgaatggca gtgtaacgtc agccttctgt ttcaaaccct 3460381 gatccttata agcagccgct ttttcatttg ctataaaccc ttgcttattg attgcagtta 3460441 agcgttcctc tgacttgccc tttgcatcgc catgatggtt cttcacttca ttttgcggaa 3460501 tagcgccaaa cgaagcaatt gtacgaagcg gggcattaaa gaacatcgtt cccgccatga 3460561 agacagtcag aatagacaaa atagcaattt gaatggcatt ggccagtgat ttcggctttt 3460621 tcttcttttt gcggaaacgg gcaaacgctt caggatcttc tttcttcctc tcttctgtct 3460681 gctctttttt atatgtctct ttttcttttt tcgatagctt attaaaccag tcaataaacg 3460741 ctttgtactc tttcacaacc gtttttgttt catcaaacat acgaagctcg ccatagtgca 3460801 tccaagcaac acggtcacac atcttttcaa tctgaccgat tgagtggctg acaaagaaaa 3460861 tcgtttttcc ttgcttttta aactcattta ttctgtctac acacttctga taaaacgttt 3460921 ggtcccccac agaaagagct tcgtcaataa ttaaaatgtc aggatcaata tgcacggaga 3460981 tcgcgaaacc gagacgcgac ttcatcccgc tggaatagtt tttaaccggc tgattaataa 3461041 aatcgccaat ctcggcaaat tcaacgatgc tgtcatacat atcatcaatt tctttattgg 3461101 ttaaccccat catcaaacac ttgagccgga cattgtcccg gcccgttaat tggttattca 3461161 aaccggcagc aatcgcaatc agcgacggct ggccgttcat ttcaatttca ccgctggtcg 3461221 gcggaataat tttagccagc aggttagaca tggtcgattt tcctgacccg tttattccta 3461281 caaagccgat tgtctcccct tcatacacgt caaaggagac attccgcaca gcaaaaaaac 3461341 cattatcctt agccggaaaa aacaatcctt taatcttgtc cgattgtttt ttatacaaat 3461401 gatactgctt tgaaacattt cgaaacgaaa cttttagttt catcgtaaaa tctccttacg 3461461 tattaaagaa agtcaacaaa cttgtctctg aatttcatat gcaggataga acctactaac 3461521 aataaaagga atgtgaacaa ccaaaagtac agcgtgtact tcatgtcatg gaaaaaccat 3461581 gctccatcta agaagctgtt ccggaatcct tcaataatat agaatagtgg attcaacttc 3461641 agaacaggca ctaattcggg gtggctttga ccgagtttcg cattaacatc ccaaaaaatt 3461701 ggcaacaaga aaaacaaaag tcttgttacg gcctgcagca aaaattgata atctctaatc 3461761 agcacactga tcgttgagtt aaacaaacta aacgaaaaca taaaagcaat catacagatg 3461821 aagtaataaa tatattgtaa ccaatgcaca ctcgggaaca caccattaac taggagtaca 3461881 atgatataaa tcaccatcat gatcatataa ctaaataagt tagatgcaat tgccacggac 3461941 ggtagagaac taatcgggaa gttcatttta gccaccatat taatgcgctt aaatacacta 3462001 tttgatccat caagtatagt tggactgatg aaaaaccatg ggattaatcc tgccagcatc 3462061 caaataataa aaggcacttc gcccgctccg gttgtcacag gaccgccctt tctaatcccc 3462121 ataccaaata cgaaccagta ggccagcatt tggataagcg gatttaagaa ctgccataag 3462181 acacctaaat aattcatttg atatttagac ttggtttcat aagccgccaa tcttaaaatt 3462241 aaaggaaatg acgttatttg ctctctgagt atacgcaaca aatcattcat tttttatctt 3462301 ccttagactt aattgttttt gggaatcttt ctgtttaaaa tttgaaagca ccgctgatta 3462361 ttgtaacaga tcctgcattt tttttcactt ctcaacaagt atctaaaaag ctgccgaaaa 3462421 atcgacagct atacatttta taaaataacc taaattattc agctttaaat acagtattaa 3462481 caaccttttc agatgaacgt cctgactcta aatagcaaaa cttatcatag aaaggaccaa 3462541 aagaaaccgg aagcttataa tcaggcgatg agatctgctt gatagcctca atcgtttctt 3462601 cagtagtttt taccaaagga ccaggagctt ctttttcaaa atcaaagtag aaaccacgca 3462661 acttgtcccg gtaggtttcg atgtcaggga caaagaatag cattggccgt tttaaatttg 3462721 caaaatcaaa gaatactgaa gaataatcag taatcagcaa atcagaaacc atatacaatt 3462781 ctcgaatatc ctcataagca gaaaaatcat atgcaaatcc ttcaaaagga cctaaatcaa 3462841 aattctcagc taccagataa tgcattctta agattacaat atattcattt ccaagttctt 3462901 gtctaagttg atgcaaatct aaatcgagat cgaacttata acgccctttt gcatagaact 3462961 gatcatctct ccatgtaggg gcatataaaa taaccttttt atcacgagga atatttaacc 3463021 tactctttat caatgatatt gtttcctcat tattatcatt atgaagaaaa tcatttctag 3463081 gatatccaga ttcaatcatt gtcttgttaa actgaaacgc ccgtgtaaag atctcagttg 3463141 aataaccatt tggggaaatc aagtaatccc aattagaagc ttccttgata aaattccttt 3463201 tatatttttt ggtgtttgta ccaggcatat ggacttcttc catatccatt gcaagtcttt 3463261 ttaaaggtgt gccatgccat gtttgtaaat atgttgtatg actaggtttc ggaatccata 3463321 atggaagccg gctgttaaca acccaatact cagctcttgc catagcgaag agccatttta 3463381 atgagaggcg attaatgtaa ggaattccct tttcatcaaa aggcgctgaa tattgtttat 3463441 ttacactcca atacatttta tactcagggt ggttttcccg catatattcg taaatcgctc 3463501 tcggattaca actgtattgt ttcccattaa aactttcaaa aatgactgtt ttccttttaa 3463561 ctggcattct gctagccatc atgaatagag atttgtatgt tttagtgatt aacttgtttc 3463621 tcatttttgt gatctttttt atttttgata ctaatctctt cttctttcct ttaataaagt 3463681 atttcatcct tgttttcagg ctatagtcgt ttactctgat acctagagtc tgctttttct 3463741 ttttcttaaa gacttcataa cgaactggtg cgttgtttgt tttaataata cttactaatc 3463801 cttttaattt gttttttcga tctcctaaaa caagagcagt gctgttgaac tgaatatccg 3463861 ttccttcatc gtcattgcat atatactcca taaaaagacg ataaacataa cgtttttcat 3463921 ttgagaaagg aatttctttc aaaggcactt tcacttcaaa atcatacagt tccggaacaa 3463981 aaccatctgc tctcatgttt tccaggccat gtgtttttct ttctagcttg attggaaatt 3464041 tttcctcaat aggtgtttct ccaccctttt ttaaaataag gttcaagttt tttatccgat 3464101 attgattttc ggaactcagg taccccgcat aacctgttat gcttatttct tcagagctaa 3464161 tctcgatttg atcaaatctg atgattttgg cctctctttt caccttaata gaaaagttgc 3464221 ctttatcagt tgtataaggt aaaatcaaaa gttctgtggt ttgatcgaca tgaaaggcgc 3464281 gctcaattga atttacttca gcagaaagac gcttcaagag tggttcctgc tccgcatctt 3464341 catatttttt tcgaaattcg acataaaaat catatgtttg tcccatttca acaggcatag 3464401 gcaaaacatg agcatttatc tcagttttat actctaatga gccagtgttt tgaagcggaa 3464461 attcagattc cgttcctgaa cgtctctctt tcagctttaa aaataactgg taatcctcta 3464521 aaaattggtg ttctgaatca attgagatta acaattcaag acttcctaaa ttgtttttca 3464581 agcttttcaa aatacattta atcacagtgt tttcaatcat tacttttttc tgctcctctg 3464641 tataaaagct ctttcctttt tgcttccttt tattagtgtc aactactaag gacattaact 3464701 ctcttttatt tccgtgaccc tccaagagaa attgccttta actgttgtat agggctctac 3464761 tctatagcca ttattagtat ctatactgtt tcctgacaat tttgtttctt cactcgaaag 3464821 tcttcgcatt gttttaatat ggccatttgc attgaaaaca atataaaaat caataacttg 3464881 ggttttatta gcagctatct tttcaatatt tacatctttt tcgagatcaa ttacaaacag 3464941 ttgatcattt tgtaagtttg ttgaaataat ttcagcctta ttctttctgt ccaagcccac 3465001 taaacgtatt tttttaatat cattatgatc aaaattctca atgtcaattt ctattttagt 3465061 tttatcaaaa tcctcagtat aggaactaat agaaggatct ttttttccaa cctttttaga 3465121 gaacttctct ctttctattc gcacctcaat catctgatta agagcaaaag cccaattttc 3465181 aatatagttg ggtcttgaat atttttcagc cattttaaaa gcttgttctg aaaatttttg 3465241 atgagtactt tcatctttca tcaaagagat aatagcttga cccaatttct ctatattata 3465301 ctgttcaatg acatatccat ttgctccgtc agtaactaag ctccttgctc cgtaatcata 3465361 atcgtatgtt acaactggac atccattgct cagtgcctcc atatttgata gaccgaaccc 3465421 ttcaaaatga gaggttgaaa tggttagcca agctttttga aactctgagt cagggttatc 3465481 cgtatagcct ttcaaaaaga cattgttctg cagtttggta tcttcaattt ctttttttat 3465541 tttttcgaaa tcttcacccg atccgaatat atcaagtttt gcttcaggaa tttctttcac 3465601 gactaaacta aatgctttta ctgcatgtat cagatttttc atagatgcaa gtcttgaaat 3465661 aatgacagct ttgtattttt cactcggcac attcaataca gcgggatcaa gaggcttatc 3465721 aattgtatgc ggagtaaaga aaaacgtctc ttgttcccct gaaatcaatt taaaatcttc 3465781 tagctgctcc tcagttataa aaaagacagc atccaaatta tacatctgac taaatacttc 3465841 tttatagcga cccttaattt gatatttatt gctgccgtaa tgcttgttat gaataattgc 3465901 tccataatag gaagaaggtg attttttcac tttaaagaca tgtttgtctt gcggtctgct 3465961 gtccactaaa aacaacttag gtttatcatt ttgtttttgc agatattcta tccaatattg 3466021 acgcagttcc gattcatctt ttacttttat ctcaccctca agggagtacc aaataatatg 3466081 agataattga acatcttttt cttcattgtt ccatacatag agtttgtcta aatatacttg 3466141 attttggtca ttaatatatt cctgcagata catcttgttt agctgcacat cataatgagt 3466201 aacgagaact aagtttccgt tcttcgtata ttcctctctc tttatgagct ggtttttatc 3466261 attccaatag tcgacgtacc ggatagtttc tccatctccg tagtaaacta cagacatttc 3466321 attgttcttc ttaccaaaca atctcaacag agtttttgca aatttcccca ttccaacttg 3466381 cttttttatc tggtcaaggc ctatcctttc ttcgtatgat cttttcccat ttgttctaac 3466441 acttaaaaaa tcatcgaata gattaataac acttgtgaat tttttatcaa tcttaccgtt 3466501 gctgtacaat tcatcaattt ttgaagacaa ctctaaatca aaacgaaacg ttaagaaaaa 3466561 ggtgttttgg ttacactctt ctccaaataa ttttgaacgc aataataatg atttcgtcag 3466621 accgccataa ttacttggca gtccaccaga gataaaataa taatccatgt caggaatttg 3466681 ttttatatta gattcactca ccgcatgtaa agacaatttt ttactccctt tcggcatcta 3466741 gaatatatga tcattgaaat ttatatctac ccggatactt tagtcacaaa aatcaatgta 3466801 agcatcaaaa agtacttctt atttcaataa gaagtacttt aattagatat tgaaccaatg 3466861 atatcaggat cctaaattat aaaccagcaa tttcctcttt gatctttgtt gtagagatgc 3466921 cttctgttct tgggaggtaa acaacctcac actgatcttt gagaaagtca aatttacctt 3466981 cccagtcatc ccccataaca aaaacatcaa tattatgatc aataatatct tgcttttttt 3467041 gctcccaatt cttttcagga attacttcgt ccacatatcg aatggtttct aaaattaatt 3467101 tacggtgctc atagctgtga taagcttttt tttgcttttg taaattgaat tcatccgttg 3467161 aaatagcaac aactaaataa tcaccaagct gctttgcacg ctcaagcaat ttaatgtgac 3467221 cccaatgcag taaatcaaaa gttccatatg tgataacttt tttcatttaa agaaacgctc 3467281 cttcctaatg ttaaacacta ttaaaaacac tactgacgtt agcgattaaa ttctaaaaac 3467341 ctgtttgtat tccttatatc gacatatttc tcgtatgtct tcactgatca ttaattatag 3467401 cataccgcct aaaaaaggtt aagtactcat gaggagaaaa acattccaaa atatgtaatt 3467461 acactcagac tccattggca ccaaggtctg ttgttcattc gttcattcaa ttgtaaaatt 3467521 ggaaacatat ttaaatttaa tgtaaagata atgttaatcc tttgttgaag atttatgtta 3467581 aaatataagg tagcttgatt ttgcttttag aaactctcgg tttttaacta tataaataga 3467641 atcttaaagg aaggaggagc cagacatgca aacagagact attcacaata ttccttatgt 3467701 taacagtaac ttaacatcat ttatcgatta cctagagaaa cattatattg atcaaaagat 3467761 tggtgctgtc atttccacag tcaaccctga aattgcattt gcagctatta aagatcggga 3467821 ctactttgat gtactatctt cttcaaactt cattttgcct gatgggatcg gtgtagtcat 3467881 gatgtcacgt ttgactaaca acaggcttca gtcccgaatc gcaggttacg atgtttttaa 3467941 agaacttctg ggcgttgcta acaaaaagaa aaaacgcata tttctgtacg gtgcgaagaa 3468001 agatgttata aaaggtgttg tatccaaaat ttcttctgaa tacccaaaca ttaaaatcgc 3468061 aggttattca gacggttatg ttcaagatcg caccctagtg gcaaaacaaa ttgcaagagc 3468121 aaatcctgac atggtattcg tagctttagg gtatcctcat caagagaaat tcattcataa 3468181 ctacagacac ttgttcccta aagccgtatc tataggtcta ggaggaagct ttgatgtatt 3468241 tagcggtaat gtcaaacggg ccccttcctg gatgatacgt ttaaatttag aatggttcta 3468301 ccggttaatc ttgaatccat ggcgatggaa aagaatgctt agcatcccaa aatatgcttt 3468361 aacggtttta aaagaagaaa aaaacaaaaa aactttctat ccaaagcctg aaaaagatca 3468421 tacaaaacag atttaaaaac aaaactttca aataaatgga tgataaaaat gaaaataaga 3468481 tcactactgg cgaattgcta tttgtatttt ttatcagcaa tcgccttttt tctgcaatgg 3468541 gtgaaacctg aaagcaaagt gaccctcctg atctcattcg aagcaaacgc aaaagcgatt 3468601 cttgaggaat atgaacaagg acaatactct tataaactta acatcctgta tacccagcag 3468661 gcctctgcta ttgccgagag cttcccgaat gtagatgcat atttattaca agaaaaaaac 3468721 cctatccatc tcattaaagc tgtataccta atgtttaaca gtaaagtgat cataacagat 3468781 aattactttc tattaacaag tgtgttaaat aagcggaagc aaacgaaatg tatccaagta 3468841 tggcacgcaa atggctcact caaaaaattt ggtttggaag acattacaaa catgcaacgg 3468901 acgaaaactg atattaaaag gttccaaaaa gtatacagtt cgtatgatta tttaactgtt 3468961 ggctcagaag agatggcaaa tatcttcaag aaatcatttg gaataaagga taaccaatta 3469021 ttaaaaatag gtgtaccttt aacagaccct tattaccgag aaaacaagaa aaaaatttca 3469081 gatactctaa acatacaaag aaaaaaaata atcctctatg caccgacgtt tagagattat 3469141 aatatgcaat caattcaatt gccttttaca gaagaacaat taattcatca gttaaaagaa 3469201 gaatatgttt tatttgttaa gctgcatccc gccattcaga acaatattga tattaaatat 3469261 tccagtgatt atattaaaga tgtttctaac tatgccttgt ttgatctact catggctgca 3469321 gacatattaa tcactgacta ttcttctgtt ccctttgaat tttcgatttt aaataaaccc 3469381 attctttttt atacttacga tttaaaactt tatcaacaga agcggggatt ggttgataat 3469441 tatctttcca taatacctgg aagagcctgc tatgacagtg aatcattaat aaatgaaatt 3469501 caaaccccat ttaattattc caaaataaaa gttttttccg atagatggaa taagtattct 3469561 gatgggaatt caagccaaaa tttattgaat ttcatcgaaa atttaataag ctaaatgatg 3469621 acacttgttc aaaacagaac aagtgttctt ttttctattg aataccgaac gtatgtttgc 3469681 tttaatgtaa ttagttgctt atggcagcaa ataataatag aggtggtaaa tttatgagaa 3469741 aaaaagaact gtttgatttc accaacatca cgccaaaatt atttactgaa ctacgtgtag 3469801 cagacaaaac cgtacttcaa tcattcaatt tcgatgagaa aaaccaccaa atttatacaa 3469861 cccaagtcgc aagtggatta ggaaaagaca acacccaaag ctatcgcata actcgtctat 3469921 ctcttgaagg tttacaatta gacagcatgc tgttgaaaca tggaggtcat ggtacaaata 3469981 ttggaattga aaaccgtaat ggcaccattt atatttggtc tctatacgat aaaccaaacg 3470041 aaacagataa aagtgaatta gtttgtttcc catataaagc aggcgcgact ttagatgaaa 3470101 attctaaaga acttcagcga ttctcgaata tgcctttcga tcatagggtt acacctgctc 3470161 ttgatatgaa gaatagacag ttggcaatta gacaatacga tacaaaaaat aataataata 3470221 aacagtgggt gacaatcttt aacctggacg atgcaatagc aaataaaaac aatcctcttt 3470281 atactattaa cattcctgac gaacttcatt atttacaagg tttcttttta gatgacggtt 3470341 atttatattg gtatacagga gatacaaaca gcaaaagcta tccgaatctc ataactgtat 3470401 ttgattccga taataaaata gtgctgcaaa aagaaattac tgttggcaaa gacttgtcca 3470461 ccagatatga gaataacttc cgtgaaccgg aagggatctg tatgtacacc aatcctgaaa 3470521 ctggggcaaa atcattaatg gtgggaatta caagtggaaa agaaggaaat cgtataagca 3470581 gaatttatgc ataccattct tatgaaaact tcatgaatca tgtacctatg cttcgatccc 3470641 ctttattaaa aaccgtgggg caccaagata cacctccaga aagatttcaa ccatttattc 3470701 aaaccttcat tttagagtat aatgctcaaa acaaaaaatg gatggttccg acttcaggtt 3470761 atttaccatc ttacacatca aatttagtcc gaaatattac tatcaatgca gatggaaact 3470821 tgcaagtcac attaaatgaa cgctatatta gtttactgca tcaatcgata gaaggagatt 3470881 tccgcttaaa acaaaaggat atccgaatgg gatcctggta ttttgccggc ggagaaaaat 3470941 caaatgtgct tgaaataggt tttatgaaag ggagtacaaa aatcagaccc gatgatgcag 3471001 ccatctcaaa tgcttcaaga atgagtattt ttatgattgt tgcggacaag attgaggtgt 3471061 gataatcaaa taggctgtag ctatttaata gctacagcct atttgcaact ttctaagttt 3471121 tttatcgata ttccggaaca tcaaaataaa gtgtataacc gtccagcaat gaatacaggc 3471181 tgtacatgcg gtttacttgt ttgtacgccc agccgatgtc tgttgcgtat tgatgtgtcg 3471241 ctgtagctga ccatctcatt ttgtacagtg tgtcttgatt gtaagctgtg ttgtggatat 3471301 acgatgagcc tatgaattta gctccgccga taatggccgc ttctggtgtg aaccagccct 3471361 gctcgtacgc atatttggct ccgtagtaat tcggattgct gtcgtatgct ccaattccat 3471421 acatgttgta tacggttttt ccgttatagg ttaatccatt ggctaaagcg gatgtcccgt 3471481 ttcctgtttc cagaagagcg tgtgagatta aatacagttc gttgatgcta tattgattgg 3471541 cggcatcgat aaatgccttt gctctccctg tcaggatgcc tttacccgca agcactttct 3471601 gatttacctc agtaacgctg agacccgctg tctgtgacag cttgagaaat tggaagtagt 3471661 atttgctgtc tctggaaaag ttattcggat ccacgtattg aactacttca tcactgcttg 3471721 cgtttcgcca gcccaaattg atcttagccc agccgtttat ctgtccgatg actttcactt 3471781 tatcgccttt tttaaactgg ccgatcacgt ttgtcgggct gacttccggc gttgaccgga 3471841 tatttagtac atcagccgta acagttgatg ttgctgtatt aatgtacgtg agcgatacgt 3471901 aagccgctcc gtctgtttgc ggacttactg tcatttgttt ttggaccata tcacgaagcg 3471961 agagattgta gtttgttttc atgatttgcg ggccgttttt gatcttcacg atagatgatg 3472021 tccatccgta taattgtttt agcttcgttg atgccgcagc agctgtatca ttgcctgtga 3472081 actgctcatt tacgctgatt ttataaagcg tattgctttt cgttgtatag ctcggggtta 3472141 cacttttcga tttaagatag gttaacccat tgttcaatgc ggttttgctg ctaagctgtg 3472201 ttgtcacgat tttgtattgt gtatatgcag tctggcctgt ttttgatgtt gtgactgcga 3472261 tatgattttg tttgaaaaat gttaaaacgc ggtcaatctc ttcttggctg atgatagctt 3472321 cagttgtgat ttgatagctg ctcgcagctg tctgaccggt tttctggctt gctactgata 3472381 tatgattcga tttgaaaaac gtgagtgcct gattgacttt cgtttgatca agcagagatt 3472441 cggttgtgat tttaaacgtg tcagctattt gttttttgac ggatttcgca gaagcactta 3472501 gctgattttt ctttaatatg ttcaaaccct ttgtgacttt tgcttgatct gatgtttctt 3472561 ctgagatgag ctgatattga ttttctgctg ttgatccagc tgctgttttt gcagctttta 3472621 cttttttctg agcaaagaag gctgctgctt tgtttgcttg ctgctcgcct aaaatctttg 3472681 ccgtcgtgat ttgataagct gcagacgttg tcgttttttt gacgctggat gacgtgtaat 3472741 gccatttttt ctttttaaag aaagtgtcta ttttttggag ctgctgtttt gttataccct 3472801 tcatattcac ggtatatgat gtgctttttc caacctgttg ataactgccg gatacgccag 3472861 tgtttttctt gatttggctg atggcgtcct ttactgtact cagccctttg aaataagctg 3472921 attggacatt gtatgactca acggttgttt tttgattgat ggacttgtag ctgcctgtga 3472981 tgccagtgct ctgtttcagc tgctgcaata gagttttggc attggcttca cctgaaatgg 3473041 cggcagttgt gaacgtataa taggcttgcc ctttcactgt ttcctttaat gatgcctgca 3473101 gcccagattc cttttggaag gcgtttttga tctgcgctgc tctgctgtct cccacgattg 3473161 tgccagactg aatggttgtg acagacaccg tgtgtgtgat gggctgatac gagcttttaa 3473221 tccccgtttg cttggccagg ctctggataa gcgccttgac ttttgtctca tcagcaatgt 3473281 ctgatgtcat gacgttcata tagggctgag ctgctccgta agcttttaca gcgccagcca 3473341 ctcccgtctc ctgtttcagc tttgctagga tagtgttggc ctgtttttct ccggagatgg 3473401 cacctgacga gatggtgaca tatggctgtt tgcttccaac aggacttgac gttcctgtaa 3473461 ttgatgtctg tttggcgagt ccgctcagta ttgctttcgc ttctgattcg ctatgaatgc 3473521 ctgaggcgga aatttggtag gtcgttgttg tgcctgaagc ctgataggat gcatcccagc 3473581 cagtatcttt ttccagtttg gcgacagctt gtgaggcttg gctttctgta ctgaacgtat 3473641 tcgacggctc tactttatat agtgagtagt cggtatacgc ggctgcctgg gcagaaccag 3473701 acatggcaaa aaaggcaagg gacgcggcgg atagaagcat aggtgcgatt agtctctttt 3473761 tcattccttc tcctctttct tattctatga gtatataaaa ctagtttatt tatcggcacg 3473821 cgcatgcttc atttataggt gaatcacttc cattttctaa taaaaaaact taacctcgaa 3473881 gtgagattaa gtttaaatat gagacacgat aagggtacaa gttcctttta tcgtaaaatc 3473941 gggcatttga gccggcaaaa taaagtgatc accttttttg agcggacatg ttttgtcctc 3474001 atacttgagc aaaccgcttc cttctatcac gctgcaaatc agaaaggatt catcctgagc 3474061 catttcagct tcgccattga tgtcccattt ataaaccgaa aaatattccc cttggacaaa 3474121 tgttttaatg gttattcctt ttcttgattc tgtcgattca tctatatacc cgtccacatg 3474181 gggaaccgtg gcggcattga ccgctttggc aaaatgaagc tctctcggac ttccgttgct 3474241 atcaagacgg tcataatcgt acacccggta tgtggcatct gaattttgct gagtctctaa 3474301 aacaagggcc cccttgcaca atgcgtgcag cgttccgctc ggcacataat agaaatcacc 3474361 cggtttaatt ttgattcttc gcagcaggcc ctcccagtca ccgctgttga tcattgtgac 3474421 aagttcggtt tttgagcggg ccgtatgccc gtaaatgatt tctgcgtttt ccttacagtc 3474481 gataatgtac cagcattccg tcttgccgag ttctccctct tcgttttctc cggcatagta 3474541 atcatcaggg tgaactttaa ttgacgtatc ttccttcaca tccagcagct ttgtcagaag 3474601 cggaaaccga tccccctcta cgccgccgaa tacttcacgg tgctcttccc aaagctcgat 3474661 caatgtcttt cctttatacg ggccatttgc aacagtgctc ggtccttttg gatgagcgga 3474721 aatggcccag cattcccccg ttgattctga aggaatactg tatccaaatc tatctcgtaa 3474781 agcggttccg ccccagattt tttctttaaa cacaggcgtt agaaaaatcg gtgattgcgt 3474841 catgatccgt acccctcccc tgtaaataac tgatcatcat tttcccggtg cgcccctctt 3474901 acaaacgccc gtataagctg cctttttcct atgacaacat atgtacaaag catcatcttt 3474961 tcattacccc ttcaaagaaa acgcttccta tctattatat cacgtcgaaa agaagctttg 3475021 tttcagcctt ttcctcgata agaataattc tccttttttg atacaaatta ataaaaaccg 3475081 tcaatatgtt taagaaggag agaaactatg caaatcgact ctgatctcca gaacaattta 3475141 gacacactga aaaaaacatt gggacaaaac gacgatatga tgttttatac atttgctttc 3475201 ggagatagca gacaaaaggc gtgtttactg tatattgacg gtctgacaga gaataaaatg 3475261 ctggcgcaat acgtcatttc tcctttacaa aaagaggcgt tggcccataa ggaatgctcg 3475321 attgaagact tatccgcctt ttttttcggc tttcaccaca gcgttgtttc tacaatgaaa 3475381 gaaatagagc agctcgtttt ttcagggcaa gccattttgc tcgctgatgg ctatcgcgga 3475441 ggattagctt tcgacacaaa gtcagtcgca acacgcagtc ttgatgaacc ctcctccgaa 3475501 gtcgtggaac gcggccctaa aataggattt attgaaaagc tgcggacaaa cacggcgctt 3475561 ttgcgtgaac ggacgagtga tcctaatctc gtcatcaaag aaatgacact cggaaaaagg 3475621 accaaaaaga aaatcgctgt cgcttatatt caggatatcg ccccagatta tgtcgtcaaa 3475681 gaagtgttta aaaggctgaa atcagtcaat atagataatt tgccggaatc ggggacgctt 3475741 gaacagctga ttgaagacga accattttca attttcccca caatattaag cacagaacga 3475801 ccggaccggg tcgaaagttc tctattagaa gggcgagtgt ccatattagt ggatggtacg 3475861 ccgtttgctt tgattgtacc ggctacggtt gacgaattta ttcattcgcc cgatgattac 3475921 agccagcgct ggatcccaat gtcacttgta cgccttcttc gttattccag catcctgatc 3475981 accatttatt tgcccggtct gtatatttct ctcgtttctt ttcacaccgg gctattgccg 3476041 actagaatgg ccatttccat tgcaggcagc aggcttaacg taccattccc gccttttgta 3476101 gaggccttta tcatgatctt tacgatcgaa ttgattcgag aagccggatt aaggctgcct 3476161 aagccgattg gacagacaat tggccttatc ggcggcgttg tcatcggaca ggcagctgtt 3476221 caggcgcaaa ttgtcagtgc gcttatggtc attgtcgttt ctgtcacagc actggcatcc 3476281 tttaccgttc cttcatacgc ctataacttt ccgctgcgga tcattcggat cggggttatg 3476341 ataagtgcaa cagcgcttgg catgtacggc gttataatgg tttatctgtt tgtgatcggc 3476401 catctcatgc gcctgaaaag ctttggccag gattacatta tcccgatcat ggcgcagcct 3476461 ggacaggatt tgaaagacac agtcatccgt attcccacga tgtttttaaa aagaagaccg 3476521 acacgaaacg atcccgaaga taacatcaga caaaggtgat ggctatgagg aaatcagagc 3476581 ataaactgac atttatgcag acgctcatta tgatcagcag cacattgatt ggtgccgggg 3476641 tgctgaccct tccccgctca gccgccgaaa ccggcagtcc gagcggatgg ctaatgatac 3476701 tgctccaggg cgttattttt attatcatcg ttctgctttt tttgcctttt cttcaaaaaa 3476761 acagcggaaa aactcttttt aagctcaaca gcattgtagc tggaaaattc atcggctttc 3476821 tattgaattt atatatctgt ctatatttca ttgggattgt ttgctttcaa gctcggattt 3476881 tgggagaggt tgtcggattc tttttgttga aaaatacgcc aatggcagtt gtggtgttta 3476941 tatttcttgc agttgccatc tatcatgtag gcggaggcgt ttattcaatt gcaaaagtat 3477001 acgcttatat ttttcctata acccttatta tttttatgat gcttctgatg ttcagctttc 3477061 gcttgttcca gcttgatttt atccggccgg tatttgaagg aggctatcaa agctttttct 3477121 ctttattccc aaaaacatta ttatatttct ccggatttga aatcattttt tacctggtcc 3477181 cctttatgag agatccaaag caagtgaaaa aggctgttgc tctgggcatc gcgacttcca 3477241 cattgttcta cagcattact ttgctcattg tgattggctg tatgactgtg gctgaggcaa 3477301 aaacggtgac atggccgacc atttccctta ttcacgcatt agaggttccg ggtattttta 3477361 ttgaacgatt tgatttgttc ttacagctga cctggacagc ccagcaattt gcctgtatgc 3477421 tcggatcctt taaaggcgcc catatcgggt taacggaaat ctttcatcta aaaaataaaa 3477481 acaatgcatg gctgctgact gcaatgctgg ctgcgacgtt tttcataacg atgtatccca 3477541 aggacttgaa tgacgtgttt tattacggga cgcttcttgg atatgctttc ttaattgtga 3477601 ttacaattcc attcttcgtc tggtttttaa gctggataca gaaaaaaata gggagggggc 3477661 agctgcaatg aaaacagcat caaaattctc cgtcatgttt tttatgctgc tggccctctg 3477721 cggctgctgg gatgtcaaag atatcgagca actatccttc gccagagggc tggcgatcga 3477781 tgagacaaat gatcaccagt acaaactgac gtatcaaaat cttcttcccc aaagcgaaga 3477841 cagccaagca tccggaaaac ccgaatttgt taatgtaacg tcccacggga aaacgattct 3477901 ggaagcagtc agtgatgtat ccatcaagga ccctcctgtt tatagcgatc atttaaaagt 3477961 gatccttctg ggagaaaaac tgatgaggaa tcaaaatgta gaccaagtcc tcaaccactt 3478021 tatccgggat gatgagctgc ggcgaagcag ctatttgatg gcagccagag ggaatgcagc 3478081 tgatgttttc acaaaaggaa accccaatca gcagcagccg atgccctccg aaaaactgat 3478141 tgatttgaca actcacagcg gatataacgg taagattatg ataccgctgc gcatcggaag 3478201 agcttctgtc tactctcaga acgggtacag ttatcttatt caagccgtga aaaacgaaaa 3478261 gggaaaagcc aagtatgacg gagcaggcat tatcaaaagg ggcagcaata aactcgttgg 3478321 gtttctttca gctgatgaaa cccaaacact gtcatgggtc atggggacga tccaaggcgg 3478381 tgtcatgccg acgacagata aaggacatcc gattacgttt gaaattaaaa agtcgaaaac 3478441 gaaaattaag cccgtcattg aaaacggaaa gcctgtcttt catatttctg ttaaaacgaa 3478501 gggcatcctg acagaagacc aaaacccgaa tgaaaactcc tttagcaaaa gttatttgca 3478561 caggctggaa aacatttttg aaaaaaagct tgaacgagat gtaaagcagg tgatggataa 3478621 actgcagcac gagtataaaa ccgatccggt ctttttatca gaccacataa ggattcaaca 3478681 ccctgactac tggaataaag taaaagggca ttgggatgaa atattttctg agactgattt 3478741 taagtacgat atttctttta aaatcattaa ctttggcacg gtgggaaagt aagcaatcaa 3478801 aagggtgcgc atgatcgcgc accctttttt atgttccgac agtctgctgt tttccggccg 3478861 ctcctccctg tccgtttttg tcccgtaaat cctgctcaat ttcttcaagg cttcttccct 3478921 ttgtctctgt cactttaaat cggacaaata agaacgccat gataccgatc gcggcataaa 3478981 tcaggaataa ataactgatt ccgatcgctt ccattaatat tggataggtt aatgaaacaa 3479041 tcagtgtccc aacgtgcaac attaaggtcg aaacaccggt cccgattcct ctgacgtgaa 3479101 gcgggaacaa ttcaggaagc atcacccaca caaccggtcc ccagctgacc gcaaagacaa 3479161 cgataaacac gcctaaacaa atgacggtcg tccatgaggc agccggagtg ttatcgaaaa 3479221 agagatttac taaagcgaga acgatcaagc tgatcaccat gcccgcattc ccgaatagca 3479281 gtaacggctt tcttccaatc ttgtcgatga ttttaatcgc tactaatgtc atgagaacat 3479341 tgactgtgcc gattccgacc gtgcctaaaa tcgaagcgga gtttccgaat ccgacgtttg 3479401 taaaggtctt tggcgcatag tagatgatcg tattcgttcc gataaattgc tgcaaaaaag 3479461 cgagtcccaa acctgcaata agcgctgggc gcacccatgg atcgaacagc tccttcagac 3479521 cgccttcatc ctgcttttcc gcttctttta tatcatgtat ttcctgatca atatcttttg 3479581 tgccacgcaa tttttcaaga attttcttcg ctttgctttc ttcgccattc gtgaacagcc 3479641 agcgcgggct ctccggcata aacaaaatgc caataagcaa gagcaatgac ggcacagcag 3479701 ccaatccaag catccagcgc cacgcttcgg catcggcaaa tatgtaattg acaatgtaag 3479761 aaagaaggat gccgaccgtg atcatcagct gattcagtga tgacagcgcc ccgcgtttat 3479821 gttttggcgc cagttcagat aaataaaggg gtacgattgt cgtcgatgtt ccgactgcaa 3479881 gtcccaaaat gatgcgaaac agcaccatga ctcctgtatt tggggccagt gccacaccaa 3479941 gaccgcctat acaaaacagc agcgcggctg ccataattgc tttttttctt ccgaaacggt 3480001 cagtcagctt gccggccgct cctgagccca atatcgcccc aaccagcaag gagctgacaa 3480061 caagaccttc tgtaaacgcg tttaagccta actccttttt cataaataaa atagctccgg 3480121 aaatcactcc ggtatcatag ccatataacg cgcctccaag agctccgaaa aaataaagcc 3480181 atatatttga ctgctttttc ataaagatga ctccctttct ccatcagctg caatgacatt 3480241 gtctgtggga tttttttaga aatcttttag cctctttttc cggccattaa acctttttat 3480301 ttttctgatc ataagttttc caatcattta cttgtatttt tttcaatgtc gccgaaacat 3480361 tttacctgct gcggcgtcca atataaggtg attcagtaca ttatcgttat caattttcaa 3480421 aaacaagaac ttataaatat aggaatattt atcgaaaaat gtctttcgag tagttgcccc 3480481 atggcaaata gaatggtacg cttcaaatat taaagaaacg tgaggtattg atatatggaa 3480541 gaacgatcac agcgcagaaa gaaaaaaaga aaactaaaaa aatgggtgaa agttgttgcc 3480601 ggattaatgg cttttttagt cattgcggca ggctctgtcg gcgcctatgc ttttgtaaag 3480661 ctgaacaatg cttctaagga agctcatgtc agccttgcac gcggagaaca atctgtaaaa 3480721 cggatcaaag aatttgatcc tggaaaagat tctttttctg tattgctctt aggaattgat 3480781 gccagggaga aaaacggcga gaccgtcgat caggcaagaa gtgacgcgaa tgtgctggtt 3480841 acatttaatc ggaaagaaaa aacagctaaa atgctgagca ttccgcgtga cgcctatgta 3480901 aacatcccag gccacgggta tgataaattc acacatgctc acgcttacgg cggcgttgac 3480961 ttaactgtga aaacagttga agaaatgctg gatattccag tcgattatgt cgtagaaagc 3481021 aatttcacgg cttttgaaga cgtcgtaaac gagttaaatg gcgtcaaagt aactgtaaaa 3481081 agcgataaag tcattcagca aatcaaaaaa gatacaaaag gtaaagtcgt tcttcaaaaa 3481141 ggaacacata cgcttgatgg ggaagaagcg ctcgcttacg taagaacacg taaagcggac 3481201 agtgaccttt tacgcgggca aagacaaatg gaagtgctga gcgccattat agataaatca 3481261 aaatcattga gctcaattcc ggcttatgat gatattgtgg atacgatggg gcaaaattta 3481321 aaaatgaact tatctcttaa agatgccatc ggcctgttcc cgttcatcac ttcattgaaa 3481381 tcagttgagt ctattcagct gacgggttat gattatgaac ctgccggagt ctattatttc 3481441 aaattgaatc agcaaaagct gcaggaagtt aaaaaagagc tgcaaaacga tttaggtgta 3481501 taatgaacgg gatggcgatt acgccatccc gttttacata tttccttgtt gaaaattatc 3481561 aaagtaacgt ttagccttaa tttatatgga ttatgtttca caggcaagct gaacatacta 3481621 cacgaagcag cttcattttt aaggaggttc ccctacatat gaaatgtatt gcgattgatc 3481681 tagacggaac attactgaat aaagaaagcg tcatttctgc ggaaaacaga gaggcgatca 3481741 agcgggccgt tgatgccggc atcctcgtca ccatttgcac gggaagagcg acatttgatg 3481801 taaaagcgct gctggatgac ttggacatcc ctatcattgc agctaatggc ggtacgatcc 3481861 acgacacggg ttaccgtttg atcagccgga cattaatgga tcaggaagcc ggtaaagcga 3481921 ttgctgatta cttactttca aaaaacattt actttgaggt atatacagat gaccatctgc 3481981 tttctccttt tgacggcgaa gctaagctgc acgcggagct tgacattcta aagagcgcaa 3482041 acccaaacga gcagacggat gacttgtggc aaggagccat gactcaattc aaacagtttg 3482101 gcattaaacc aatccctcat atcgaatcgg tttttgacgg cggtgaaaac atttataagc 3482161 ttctttgctt ctcctttgat atggacaagc tgaaacaagc gaaggaagaa ctgaagcatc 3482221 ataaaaaact ggcgcaaacc tcttcaggaa aacatattat cgaaatcctg ccggcctcgt 3482281 caggaaaagg acgcgcgtta acaaagctgg ctgacatata cggaattgaa acacaggata 3482341 tctatgcgat cggcgatagt ccaaacgatt tgtccatgtt tgaagtcgcc ggacaccgta 3482401 tcgccatgga aaatgcgatt gatgaattaa aagaaaaaag cacctttgtc acaaaaagca 3482461 atgacgaaaa tggtgtggcc tactttatag accagcttct ttcggggcaa tatgcataaa 3482521 gaaaagactc cagagattgg agtctttttc ttttattgca cccgtatact tcctgcgtat 3482581 ttatccttcc aatatgtgct cgtgttcata ttggtaatgg tcacgccgtt tgataatgtg 3482641 acatgaacaa cttgtccgtt tccgatatag atggagggat ttaagcttgt tgattgaaag 3482701 aacacaatgt ctcccggctt caggtccgcc ttctcaatct tagttccggc attgtactgg 3482761 cttgttgcgt atcgaggcag ggaaataccg gctgctttct ggtatacata ttggacaaat 3482821 ccagctgtat caaatcccgt ctcaggtgtt actccgccct gtttgtaagg cacttctccg 3482881 acataaagcg tcgcttcgga aacaatcgga ttttctttcg ggattgtcag gttgtcaaat 3482941 cggcgaatac ccgtcatctt cgatttccag taatcctctg acaaatagga aatggttact 3483001 ttttctgacc ggcttgcctg aatgaacctg cctgcgcccg cataaatgcc tgcatgtgaa 3483061 attcccgttt tatacgtatt gctgaaatag acgacatcac caggctttat gttctgaggg 3483121 gctaccttct cgcccactgc ccactgctgt tcggctgatc gcggtagata aatgccgagt 3483181 gcctgttgaa acacatattg cacaagcccc gagcaatcaa agccctctga cggcgtgctt 3483241 ccgccaaaca catatgggac accgatatat ttttcggcct cctgaacgac aggaacatca 3483301 gccgttgccg gatcggcagc gattcgtctc gccccgatat aagttccgct ccaatagctg 3483361 ctttttttgt aattggtgat gataacccct tttgactgtg tactgtgaac catttggccg 3483421 tctccgatat aaagggcgtc atgtgtcgga acagtgccgg tgcttccctc tttcttgaaa 3483481 aacaaaatat cacccggctt caggttttcc ggttttacag ctgttccgat tttatactgg 3483541 tcgtttacag atctcggcag atgaatatca gccttactga acacatattg tatcaatcct 3483601 gatggatcga aaccctcttt cggcgtttcc ccgccatatt tatactgata tccaagcagg 3483661 ttttttgctt cgctgacaat caattctgat gatgtatcag cttccgcaat ctccgctttt 3483721 gtcataattg gaaccaaaaa acaaatgata accgccacaa gcaaaaactt cttccagttt 3483781 gccagtgtgt tcacttttat tatctcctcc tctttttgca gttttaacat cggtattttt 3483841 ttgaatatgt taagagactt tttaatattt ttacagaatg aatatgctgg gcaaataaaa 3483901 agagagtgtc tcatcagaca ctctcttttt tgaattattt attggcgttt accggttctt 3483961 cctgctgctg gattttattc atttccatat caatcttctg tttttcctga tctgtcagct 3484021 gatcattgaa tttaaaagct gacataaaca tgaacacgat ggctacggca acaaacggcc 3484081 agatggcttt gacaaatttc atctttatca ctccgattat ttagatttta gtttgtcact 3484141 atgatcaata tcaaacgtca gttttccgtc ttctactttc caagcgaaat tagagtcttt 3484201 cgtcagttcg cgaataatgg ttttctgttt aaggctgtct tttttcacag gcgcaggtgt 3484261 cgcttcatgg atatcgatcg gtgtcacttc aaagcgtcct gttccatttt tcttcaggtg 3484321 atactgaacc agtgcactgt ctcttgttct cgtccagcct tggtcaaaga caaagttgcc 3484381 gaggctgtag aaaatgacgg ttccgttata tacttcaatc ggttctaaga cgtgcgggtg 3484441 atggccgacg atgatgtcag ctcccgcatc agacatggct cttgcaagct ggcgctggcg 3484501 gtcatttgga tcattgtcat actcttgtcc ccagtgtgac tgcacaacaa caatgtccgc 3484561 atgttttttc gcttctgaaa tcatagggat gaagatttca ggatctgcgg gcagcacgcc 3484621 cggcgtattc tttttagccg cgaaaccttt cccggacaca tcggtaaagc caagcgtcgc 3484681 aatcgttacc ccgttgactt tctggtacga aattttcttt ttcgcatcac ttaagctgta 3484741 tcccgctcca acgatatcaa gattttgctt cgcaaattct ccaagcgtat ctttcatgcc 3484801 ctgaacgccg taatccattg cgtggttgtt ggcgctgttg agaaccgtga aattcatatc 3484861 cttcaagact ttcactgatt ccttattcgt ctgcagatga atctctttat ctgcttgttt 3484921 ataattcttt tgataggtta ccgggttttc aaagtttcct gctacataat ccgaggctct 3484981 aaagatcggt tcaacatatt gaaaaatact gtctgcccct ttttgctccg ttactttttc 3485041 aacatagcgt cccatcataa tatcgcctac aaatgaggct gagagtacgt cgtcagaata 3485101 cgttttgacc ttcggcgttt ccgcttttcc cgcccacatg aaagcgaaca taaggacaaa 3485161 aacgatcgga atggcaataa atacgtgctt attggttttc tttttttgct gttttgtcag 3485221 ctttagcagc ttttcatgaa agctcagttc ttttttcatc gtttgacaca ccttacatta 3485281 aattaagtag taaacaaaca tgatagcaaa ggtcgctccg ctcaatagca gcgtgcttcc 3485341 gaacgtaatg gttaaacctt gtttctgaat ggtattggca attaaacctg gcacgatgat 3485401 gccgattcct cgaaattctg cgatttcaaa tggtacaatc gggtatagaa aatcaaacgc 3485461 gatttttagg acgatccctg ttatcagcat ggcagcgaat tttctgcgtc cgtacaaaat 3485521 cataaatttg gataaaccgt atttcacaat gacatacgtg agcaagctca ctagcaaaac 3485581 aagtaaaata aagaccggct gattaaacac aagtcctaaa tatcccggta caacaagtcc 3485641 tgccggcacg atccctgttt tttccgcaaa aattaaactg agtagtacac ctaaaattag 3485701 tgcgatgtat aaatctgatc cgaacatgtc tgcatttccc cctagcttac gagctgcttt 3485761 accttgtatt cgtggatttt ttcaattaaa ggctctgcgg caccatgaat attgccgacg 3485821 ccatatatga cacggttgtg cattcttttc tttaacaatt ccataatttc atctgttgac 3485881 ttatactcta gatcatgcag tttgtctgca ggaattttgc cttcttcgta ggcttttacg 3485941 atcggttctg ttgtttcacc gattaagatc agttcacttg cttcaatata aggcaatacg 3486001 tcatttgcga attgctgtgt ccgatcgaca cggtctgcgc ggcagttcat gatgatgatc 3486061 ggatcatcgg tcgggtaacc gatttctttt acacgtttcc atatattcaa agtagaagaa 3486121 gcgtcgtttg cggcaaaccc attaacaaag tgcccaggct cgctcggact gatcagcgga 3486181 agaattctca ttgctcccgg atctggcggc gcattcagca ttcccttaaa tgctgtttct 3486241 tcgtcaatgc cgagtgcttg agccacaccc agcgccagag aagcgttatc agggaatacc 3486301 atgtattcaa atttacgtaa atactcatct gtaatttttg agttatcagc aatgatgact 3486361 tttgtgtttc gttcttttgc tttttgttta aagaactcgg tatattcact atctgtaatg 3486421 acaagatggc cattataagg aattgtagca gtaaacgctt ctgcaatttc atcaagcgtc 3486481 ggccccatga catccatatg gtcttccaaa acattcacaa tgacgccgat attggcctgc 3486541 agaagttctt cctgaaagat gatttgataa tctgggttaa cagccatgca ttcactgaca 3486601 atcgcgttag cccctctttc tactgtttct ctcatgactt ctttttgctc tccgatattc 3486661 ggcccctgag gtttccgttt aatcggcttt tcctccggtg tgtcccagta aatcattctt 3486721 gcatctgttc ctgttgtttt tccaacagtc ttgtaaccgg cttctattaa tattccggtt 3486781 gtcagccttg tcacagtcga ttttccgcgg atgccgttaa tattcacccg aacagggagg 3486841 gcatcaatgt ttttctgatg tcgtcgtttt tctaatattc cgatgaccag tatgacagca 3486901 caggctataa tgagtaacca cattgctttt cgacatctcc ttctatattg ttgtaaattc 3486961 attcatcagt atatagaatc actatgaatt ctcaatcggc attatgtaac ataatcttcc 3487021 ctaatcgact aagccaaact tctcttttga aagagatttt atacctacaa actgttttct 3487081 atttttggaa aacagcagga cttatacctt atcacttttt aaaaaaatca aagagaatgc 3487141 gctttcattt ttctcctgat atccttctgg acgtatagtc acaccctgct gtttgtattt 3487201 aatatgcatt tcaaatcaat ctttttttca gcctttgtta tcaagcattt cctgctatca 3487261 tgcgtgtttc cggttcttat gaacacaaaa taattttatc ctgtttctta aggacaaggt 3487321 cataatgtca tcctttctgc atggaataag caatatgagg cccattccaa aatgactaag 3487381 gaggttcgag atgaaaacgc taaacatacg agtccgaatt ctctaacata attaaacatt 3487441 ttctgggatg atagtctttt ctgtttctcc ccatttacag gtctaaacgc atgactttga 3487501 aacaatttta ataaaactta atatttgttc aagaaatctt catccatatt tgtgaagact 3487561 ttgtcaaaaa aagagtgaaa accttaaatt tttcaattat atatacaatt tacaattaga 3487621 tttcttttga tatttttatt gctaacttcg gattgttcat gataatctat ctatgtaaac 3487681 ggttacataa acaaggagga gctgttttgg ctacaattaa agatgtcgcc ggagcggcgg 3487741 gcgtttcagt tgcgacggtt tcccgcaacc tgaatgataa cggctatgta cacgaagaaa 3487801 cgcgaacgcg tgtcatagcg gcgatggcga agctgaacta ttacccgaat gaagtcgcca 3487861 gatctctata taaaagagaa tcccgactga tcggactttt gctcccggat atcacaaacc 3487921 ctttcttccc ccagcttgcc cgcggtgcgg aggatgaatt gaaccgggaa ggctatcgcc 3487981 ttattttcgg caacagtgac gaggaattga aaaaagaact tgaatacctt caaaccttta 3488041 agcaaaatca tgtcgcaggc attattgccg caacgaatta cccggatctc gaggaataca 3488101 gcggcatgaa ttatccagtt gtttttctgg acagaacgct tgaaggggct ccttctgtgt 3488161 ccagtgacgg ctatacagga gtaaagttag ccgcccaggc tatcattcac ggaaaaagcc 3488221 agcgcattac gctcttgaga ggacccgctc acctgccgac cgctcaagac cgatttaacg 3488281 gcgctttgga aatcttaaag caggctgaag ttgattttca ggtcattgag acagcttcat 3488341 tttcaattaa agatgcacaa tcgatggcga aggagctgtt tgcctcttat ccagcgacag 3488401 atggtgtgat cgcgagtaat gatattcaag ccgctgccgt tttacatgaa gcattgcggc 3488461 gcggaaaaaa cgtgccggag gacattcaaa ttatcggcta tgatgacatt ccgcaaagcg 3488521 gacttctgtt cccgccactt tctacaatta aacagcccgc atatgatatg gggaaagaag 3488581 ctgccaaact gcttttgggt atcattaaaa aacagccgct ggcagaaacg gcaattcaaa 3488641 tgcctgtcac ctatatagga agaaagacga caagaaagga agattaagat gcgtaatatt 3488701 tgtgtgattg gtagctgttc tatggattta gtggtcacct cggacaaacg cccaaaagcc 3488761 ggtgaaacgg ttcttggcac gtcatttcag actgtgccgg gcggcaaagg agcaaatcag 3488821 gccgttgccg cagccagact tggggcgcaa gtgtttatgg tcggcaaagt tggagacgat 3488881 cattatggaa cagctatttt gaataatctc aaagctaacg gcgttcgcac tgattatatg 3488941 gaaccggtta cacatacgga aagcggaacc gctcatattg tgcttgctga aggcgacaac 3489001 agcattgtcg ttgtcaaagg cgcgaacgat gacatcaccc cagcgtatgc gttaaacgcg 3489061 ctcgaacaga ttgaaaaggt cgatatggtg ctgattcagc aggaaatccc agaagaaacg 3489121 gttgatgagg tgtgcaaata ctgccattct cacgatatcc cgatcatact aaacccagca 3489181 ccggcccgcc cgctcaagca ggaaacaatt gatcacgcta cctatctgac gccgaatgaa 3489241 cacgaggctt cgattttatt ccctgagctt accatttccg aagctctggc gctttatccg 3489301 gcaaagctct ttattacgga aggaaaacaa ggcgtccgct attcggctgg cagcaaagag 3489361 gtgctcatcc cgtccttccc tgtagaaccc gttgatacaa ccggagccgg tgatacgttt 3489421 aacgcagcat ttgccgtggc cctggctgag ggaaaagaca ttgaagccgc attgcggttt 3489481 gccaatcgtg ccgcttccct ttctgtctgc tccttcggtg cccaaggcgg aatgccgaca 3489541 agaaatgaag tagaggagct gctgtcatga aaaaacacgg tatactgaac agccatcttg 3489601 ccaagatttt agccgacctt ggccacactg ataaaattgt catcgcggat gccggactgc 3489661 cggttcctga cggcgttttg aaaattgatc tttcactgaa gccgggcctt ccggctttcc 3489721 aagatacagc ggcagtactg gctgaggaaa tggcggtcga aaaagtcatt gctgcagctg 3489781 aaataaaagc atccaatcag gagaatgcga aatttctaga aaatcttttc tctgaacaag 3489841 agattgaata cctttctcac gaggagttta agctgctgac aaaagatgca aaggcagtca 3489901 taagaacagg agaattcaca ccatatgcca actgcatcct gcaggcaggt gtacttttct 3489961 agaaaggaag atgaaacatg cagattgaaa tgaaagacat tcataaaaca ttcggaaaaa 3490021 atcaggtgct gtcaggcgtt tcctttcagc tcatgcctgg cgaggttcac gcattaatgg 3490081 gagaaaacgg cgccggcaag tccacgctta tgaacatttt gacaggcctg cacaaagcag 3490141 ataaaggtca aatcagcata aacggaaacg aaacgtattt ttccaatccg aaagaagcgg 3490201 aacagcatgg aatagccttt atccatcagg aattgaatat ctggccggaa atgaccgttc 3490261 ttgagaatct atttatcggt aaagagatat cctccaagct gggcgtttta caaacaagaa 3490321 aaatgaaagc gctagcaaaa gagcaatttg acaaactttc cgtctctctt tctcttgatc 3490381 aagaagccgg cgaatgttcc gtcggacagc agcaaatgat cgaaattgca aaagcgctta 3490441 tgacaaatgc cgaggtaatc attatggatg aaccgaccgc agcgttgact gaacgtgaaa 3490501 tcagcaagct ctttgaggtc attacagcgt taaaaaagaa cggcgtctcc attgtctata 3490561 tttcgcatcg catggaagaa atttttgcga tttgcgacag aattaccatc atgcgtgacg 3490621 gaaaaacggt agatacaaca aacatctcag aaactgattt tgatgaagtc gtcaaaaaaa 3490681 tggtcggacg ggagctgact gaacgatatc caaaacgcac tccttctctc ggtgacaaag 3490741 tattcgaggt gaaaaatgct tccgtaaaag ggagttttga ggacgtcagc ttttatgtgc 3490801 gttccggtga gatcgtcggt gtttcaggat taatgggagc cggccggaca gaaatgatga 3490861 gagcgctgtt cggcgttgac aggctggaca cgggtgagat atggatcgct gggaaaaaaa 3490921 cggctattaa gaacccgcag gaagccgtga aaaaaggtct cggctttatt acagagaatc 3490981 gcaaggatga agggctcctg ctcgacacct cgatccgcga aaatattgcc ctgcccaatc 3491041 tgtccagctt ctcaccaaag ggtctcattg atcataagcg ggaggctgaa tttgtcgatc 3491101 tgttaatcaa gcgcctcact atcaaaacag catcaccgga aacgcacgca cgccatttat 3491161 caggaggaaa ccagcaaaaa gtggtgatag ccaagtggat cggcatcgga ccgaaagtgc 3491221 ttatcttgga tgagccaacc agaggtgtgg atgttggcgc caaacgagag atttatacgc 3491281 tgatgaatga gctgaccgaa cgcggtgtcg ctatcatcat ggtgtcatca gagcttcctg 3491341 aaattctggg aatgagcgat cggattatcg ttgtccatga aggcagaatc agcggcgaaa 3491401 tccatgcgcg agaagcaaca caagaacgaa ttatgacact tgccacggga gggcggtaat 3491461 atgaaaacgg aacaactgca aacagaacaa aaacggattc acttcgacgg agtcatgcaa 3491521 aaactcggcc cgtttcttgg tttatttatt ctcgttatca ttgtatctat tttaaatccc 3491581 agctttcttg aaccgctgaa tattttaaac ctgcttcgcc aggtcgccat taacggatta 3491641 atcgcgttcg ggatgacctt tgttattttg acaggcggca ttgatctttc tgttggcgct 3491701 attcttgccc tgtccagtgc tttagttgcg gggatgattg tgtccggtgt cgatccggtt 3491761 ctcgcgatca tccttggctg tatcattggt gccgtactag gcatgatcaa cggattattg 3491821 attactaaag gaaaaatggc gccctttatc gccacgcttg cgaccatgac tgtgtttcgc 3491881 ggactgacgc tagtgtatac agatggaaat ccgattaccg gacttggcac aaactacggt 3491941 tttcagatgt tcggacgcgg ttacttttta ggcattcctg taccggcaat tacgatggtt 3492001 cttgcctttg tcatcctttg ggtgcttctt cataaaacac cattcggacg ccgaacgtac 3492061 gctatcggcg gcaacgaaaa agccgcgctc atttcaggca tcaaagtgac gcgcgtgaaa 3492121 gtgatgatct attctttagc cgggctttta tccgctcttg caggtgccat attgacttcc 3492181 cgcctgcatt cggcccagcc gactgcggga gaatcgtacg aacttgatgc tatcgcggca 3492241 gtcgtcttag gagggacaag tctttccggc ggccgaggac gcattgtcgg cacgttaatc 3492301 ggggtgctga tcatcggcac acttaataac ggacttaatc tgcttggcgt ctcatcattt 3492361 tatcagctgg ttgtcaaagg gattgttatc ttaattgcgg tattgttaga ccgcaagaag 3492421 tcagcttagg agggttttac atgaaaaagg ctgtatccgt cattttaacg ttatcattat 3492481 ttttgttaac cgcctgttcg cttgagcctc cccaatgggc aaagccatca aactcgggga 3492541 acaaaaagga attcaccatt ggcttgtccg tctcaacgct taataatcct ttttttgtct 3492601 cattaaaaaa gggtatcgaa aaagaagcta aaaaacgggg aatgaaagtc atcattgttg 3492661 atgcacaaaa tgattcatcg aaacagacga gtgacgtgga agatttaatt cagcaaggtg 3492721 ttgatgcatt attaatcaac ccgactgatt cttcggcgat ctcaacggca gtagaatctg 3492781 caaacgcagt cggtgtgccc gtcgtaacaa tcgatcgatc tgcggaacaa ggaaaagttg 3492841 aaaccctcgt tgcttccgat aatgtaaaag gcggtgaaat ggccgcggcg tttattgccg 3492901 acaaacttgg aaaaggagca aaggtggcag agcttgaagg cgtccccggc gcatctgcca 3492961 cacgggaacg cggctcagga ttccataaca tcgcagacca aaagctccaa gttgtcacaa 3493021 aacaatcagc tgactttgac cgcacgaaag gcctgactgt catggaaaac ctgctgcagg 3493081 gacatcctga tatccaagct gtttttgctc acaacgatga aatggcgctc ggtgctctcg 3493141 aggcaattaa cagctcgggg aaagacatat tggtgatcgg ttttgacggc aataaagatg 3493201 cgctcgcttc cattaaagac agaaagctgt cagccaccgt cgctcagcag cctgaattaa 3493261 tcggtaaatt ggctacagaa gcagcagatg atattttgca cgggaaaaaa gtgcaaaaaa 3493321 caatatccgc gcctctcaaa ctagaaacac aaaaataatt gtctgatgtt taggaacctg 3493381 cgataacgtg aatagagata tagaatgaat tatttctctt acgtgaggag aggaacggca 3493441 tgaacaaacc aacaaaacta ttttcaacat tagcacttgc ggctggaatg actgcggcgg 3493501 ctgctggcgg cgctggcacg atccatgctc aacagccaga aacaacggta agcattgatg 3493561 atttatacag ttatccgatt gattcttatt tggtatcagc agaggctcta aatgtcagaa 3493621 cgaagccttc cgcatcaagc cagaaagccg atacgctgca cttaggagat agcctaaagc 3493681 tgatttcctt ctcaaatgct gactgggcaa aggttaagta taaaaatgga aaaacaggat 3493741 ttgtatccac tcattacatt gttaaagcag cgacaacggt aaaaaccaaa acaaaaacaa 3493801 aagtgtatac atccgctgac ggaaagagca ttaagactct tccagcagac acaagcgttt 3493861 cttttttagg ctggagtaaa acgaataaag gcggttttga ttttgattgg gtattcgttg 3493921 attacggcgg tacgacaggt tatatgaaaa caaaggattt acacatgaca aaataactga 3493981 gagggattcc gcataaatgc ggaatccctt ttattatgaa ttgatttgtc acattcccaa 3494041 gatatttctc aggaaatatt gtcgtatgct gtgtcgaaac cttacatgat catcgacatt 3494101 tttgttcacg ctaaaaagcg gaggtgtaaa tatggatcaa tttgaagcag catatgaatc 3494161 gtataaagcc cggcaaacaa ctgccgatca agaaaatgtt ccatctggaa aagaagaaat 3494221 tattgcggtt agaagaaatg aggaagacaa tattatcgca gtgaaaacca atacaggaag 3494281 agagctcgac taccctactg cgctgtcaga agcaaaatca ggaaaactcg ctcatgttga 3494341 tgtcttccat aaatacgggc gtgacatttt gcgaagtgaa ccggacggca tcaaggaaaa 3494401 taacctgtct gagctgccgg atttttaaac aaatacagcc ctgccgtatg ttggacaggg 3494461 ctgtatttta aacaaaaggc tgctggatgt attcggctaa ccgttttgca ctgtgagaaa 3494521 tatcctctgc agctgcataa ttcacgccat agaacacata tggaggcaga tacttcatgc 3494581 cgatcagatt actcgtggcc tgaaatggtt tcaatagctc actgatcgag taatgatttg 3494641 ctccgcccgc ttgatatttt tccgcttcgc tccctgttga tacagccagc atcagctcct 3494701 tgccatgcaa ggcatttcct tctgaaccaa aagcccagcc ataagtcagc acaagatcct 3494761 gccatttttt caagagcggc ggagagctgt accaatatag cgggaattga aagacaatcc 3494821 gatcgtattc ctcgcacagc tgctgttcct tcgcaacatc tatcgcttca tccgggtatt 3494881 ccttataaag atcccgtact gtgatattgt catgtttact caattcctca gcccacgcct 3494941 tattaacaac tgaggtctcc atatgaggat gcactgccaa aaccaatatt ttcatcagac 3495001 cacaccttta ctgttttgat gttattttat ctaaaatcag gaaaagagcc aaataaaaag 3495061 aaagccctgc taaaaggggc tttctttttt tcttttattc agggcttcct tcagttgttt 3495121 cgatatcttt cgcaaaatca gggttatcca gattcgcatt aaagaaatcc gctgtgttcg 3495181 gaagtctgag attcatgttc attttttgag aaatcgtaac cgtgcaatcc tcaagcacat 3495241 agtcaaaaac gtgtccgcct gaattgcgtc cttcgtcaat gaagtgcagg tgatagccag 3495301 aaacggcgat tccgtttgca taagctggtg tcaagaaacc tacaatcgtt cctctcacgt 3495361 tgtcgaagtt gaaaatcggc tgtgttttga ccgcttcaac cattggcacg taaggttttt 3495421 cttgaagttc tactgttctt gtctgcacct ttttaaacaa tccgtcaatg cgaattgcat 3495481 aaaataagtt tctgcttggc agcatgctgt tgatctcttt ttcaaagtct tcgcgtgtca 3495541 ttttcgcatc aattttgtgc gtcatgtccg gtgtaaagaa cgtaaatgaa cagaacggtg 3495601 aacggtctcc attttggacc ggtgtcgcgg ttccgtctga gcgaagacgg taaaattcgc 3495661 cgtcaaaccc aatcagctct ccgtcaagct tgttaaaggt tccgataccg aagtctccat 3495721 atttcggaat ctctgacagt tcaaaatctc cgtcatatac tccgtctaat agagaagtca 3495781 ttgttgatac ttgataaatc tggctcacag gctgatcttt ttgaccacgg ctgagcactt 3495841 gaatgttgct ttctcgtttc atatttccct tcactccttt tatttagtgc tgttcataaa 3495901 acagtgtcgt gatgcgcaga gtgctagaga gctttcgttt tcatgagttc cccgaattct 3495961 ttcggaagct tgtcacttgc taaattaatg ttatcactgt agtcaaccgg gacatcgatg 3496021 atgacaggac cttcagcgtt catgccttga cgcagaacat ctgccagctg gtctggtgat 3496081 tctacgcgca agccagttgc tccgaagctt tccgcatatt tcacgatatc gatatttccg 3496141 aaatcgaccg cagatgtacg gttatatttt ttcaattgct ggaatgcaac catgtcatat 3496201 gtgctgtcgt tccatacaat gtgtacaatt ggtgctttta gtcgaactgc tgtctctaat 3496261 tccattgctg agaataagaa accgccgtca ccagagacag aaaccacttt ttctcccggt 3496321 ttcaccaatg aagcgccgat tgcccaagga agcgcaacgc cgagtgtttg cataccgtta 3496381 ctgatcatta atgttaacgg ctcgtagctg cggaaataac gtgacatcca aatggcgtgc 3496441 gaaccgatat cgcaagttac tgtaacatga tcatcgactg cattacgcaa ctctttaacg 3496501 atttcaagag ggtgcgctct gtctgatttc caatctgcag gcacctgctc accttcatgc 3496561 atatattgtt ttaaatcaga aaggattttc tgctcacgct ctgcaaattc cactttcaca 3496621 gcatcgtgtt cgatatgatt gatcgtggac ggaatgtcac cgatcaattc aagatcaggc 3496681 tggtaagcat gatcaatgtc agcgataatc tcgtctaaat ggataattgt ccggtctcca 3496741 ttgatattcc agaatttcgg atcatattca atcgggtcat agccgatcgt cagaacaaca 3496801 tctgcctgct ctagcagtaa atcgccaggc tggttgcgga acaaaccgat acggccaaaa 3496861 tattgatcct ctaaatctct agaaagggta ccggcagctt gatatgtttc aacaaatgga 3496921 agctgaacct ttttcaaaag cttgcgaacc gctttaattg cttccggtct tccgcctttc 3496981 atgccgacca aaacgacagg aagttttgct gtttggattt ttgctatggc cgcactgatt 3497041 gcatcatctg ctgcaggacc gagttttggc gctgcaacag cacgcacgtt tttcgtattt 3497101 gtgacttcat tcacaacatc ttgcggaaag ctcacaaaag cggccccagc ctgccctgct 3497161 gacgctatcc taaatgcatt tgtaacagct tccggtatat tttttacatc ttgaacttct 3497221 acactgtatt ttgtaatcgg ctggaatagc gccgcattat ccaaagattg atgtgtccgt 3497281 tttaaacgat ctgcacggat cacgtttcca gcaagcgcaa cgacagggtc tccttcagtg 3497341 ttcgctgtca gcaggcctgt tgccaagtta gaggcacccg gtcctgatgt gactaacacg 3497401 actcccggtt ttccagttaa acggccgact gcttgggcca tgaatgctgc gttttgttcg 3497461 tgccgggcaa cgataatttc aggtccttta tcttgtaaag cgtcaaatac cgcatcaatt 3497521 tttgcacctg gaatgccaaa tacatgtgtg acaccttgct ccactaagca atcaacaaca 3497581 agctccgccc ctctgttttt cacaagggat ttttgttctt ttgttgcttt tgtcaacacc 3497641 ctcactcctt attatgcatt ttaaacgtaa aattttaaat atcttgtgat aagtttcact 3497701 atacactctt tggaaattga cctccaatat cgattcgcct tatgattaat atgtaatacg 3497761 aattattaac ctatggaaag gaatgcatat tgaatggagc ttcgccatct tcaatacttt 3497821 atcgcagtag ccgaagagct tcatttcgga aaggctgccc ggcggctgaa catgacgcag 3497881 cctcctctca gccagcagat caaacagctg gaggaagaag tcggagttac gcttctgaaa 3497941 aggacaaaac gatttgtcga gcttaccgca gcaggagaaa tctttttaaa tcattgccgc 3498001 atggcattga tgcaaatcgg acaaggaatt gaactggcac agcggacggc ccgcggcgag 3498061 caaggccttc tcgtaatcgg ttttgtcgga tcagctacat atgaatttct gccgccgatt 3498121 gtccgggaat atcgtaaaaa attcccatct gtgaaaatag aactgcgtga aatatcctcg 3498181 tctaggcagc aggaggagct actaaagggc aacattgata ttggtatact tcatcctccc 3498241 ttacagcata cagctttaca tatcgaaacc gcccaaagca gcccttgtgt tttagctttg 3498301 cctaagcaac acccattgac ttctaaggaa tcaattacga ttgaggattt aagagatgaa 3498361 ccaattatta ctgttgctaa agaagcatgg cctactctat acatggattt tattcagttc 3498421 tgtgaacaag cgggcttcag acccaacatt gtccaggaag ccacagaata tcaaatggtg 3498481 attggtttag tcagtgccgg aattggtatg acatttgttc cttcctcggc caaaaaatta 3498541 tttaatttgg atgttactta tcgaaaaatg gaccaaatac agcttaatgc agaatgggtt 3498601 atcgcttacc gcaaagacaa tcataatccg cttataaagc attttattca tatttcaaat 3498661 tgtcagcaga caagaactaa agagagtgat gcaggtacat gaacaatact tgcaatctct 3498721 tttttctttt gggattctta tggaattttt attaatttaa tataatcgct tagtacaact 3498781 ttatatcagt atacgtatac atacagtaca aatagttggc aaggacatca gtaagcgcag 3498841 gacattagtt tgattttaaa aatgaaagat agagaggtga agtaaattat tgagttcacc 3498901 ggcatattca cattgctcgc ttttttcgta acaatgattt ttattttctg gagaccaaaa 3498961 ggactaaatg aagctatccc cgccacattt ggcgctttaa tggttttatt gtgcggaagt 3499021 gtgtcattgg cagacttagg ggaaatcgga acaaaagtca cgggtgcatc ggttacaatc 3499081 cttgccacta tgattatggc cattgcacta gaaagctttg gtttctttta ttgggtggct 3499141 gcaaaactgc tccaacaatc caagggttca ggcatcaagc ttttttggct aaccaatttg 3499201 ctctgctttc tcatgaccat tttccttaat aatgatggga gcattttgat cacaactcca 3499261 atccttttgc ttgtactaaa atatttaggt ttaaaaaaac atcaaaaagc cccatattta 3499321 ttaagcggtg ttttaatagc cacagcctct agcgcaccga ttggcgtaag taatattgtt 3499381 aatttaattt ctctcaaaat cattggaatg gatctatatc ttcacaccgc catgatgttt 3499441 gtccctagta tgatgggact catttttatg acttgtctac tgtttatgtt cttttataaa 3499501 cgtcttccca aaagcctgcc agatataccg ggccattttc agtctctgcg gcatagaagg 3499561 taccatcctc ttcattcgcc atcagctcct ttaccagaac gaaatcaaac aaaaatcatg 3499621 ttgtttgtgc ttgcatttgt ttttctcgtc agaatgagtc tatttgcagc atcatatacc 3499681 ggtatttctg ttcctctagt cgctgtcatc ggatctttta tcctgttgag ctggagatgg 3499741 atttatttca aaacctcccc aagagacttg ttatataaat cgccttggca catttttata 3499801 ttcgctttta ctatgtatgt cttaatttat ggtctgcata atattggatt cacagagtta 3499861 cttgtgagtt attttgaacc tgtggtttct ggaagcctcg cccatgcaac tttcgcatca 3499921 ggtatctcta cttcagtttt ttctaatctc tttaacaacc atccagcgtt aatgatcagt 3499981 acttttacct taactgaaat gaccctgaat ccttcaacaa caaaaatcat ctacttggca 3500041 aatattatcg gcagtgatat cggttcatta ttattaccta tgggaacctt agcaacgctt 3500101 atttggatgc atatattaaa acagcatgat gaaagtattt catggggcga atatataaaa 3500161 acgaccatta tcatcattcc gctgactgtt ctttttacgt taacatgttt atatttttgg 3500221 atcagttggt tatttcttta gcacagtatg aaacgaaaaa ctgccttctg cttttcaaga 3500281 gggcagtttt gtatacacta gggaagatgc attgtcttta gatgatttaa cttccaaatg 3500341 actggctctc cacttgcgtt aataagctca atgatattat tagagacacc ctttaatagt 3500401 ccgacttttt ctggcacctc tcccatatca aatatgacca attcaccaat attttttttg 3500461 atctgctcct caaaattacg cacaagagga actttggaag gcacgaccgg caattgtgag 3500521 ttgtcaagag tatacggtgt ttgttcagtt gaataagggg taaaccattt taaatgatgc 3500581 atagatataa aaagtatttt aaatacgggt gagaaaaata caatataatc gtttaaaaca 3500641 tttgtaacat atccatggat cgatcgaccc ccagttacat aaacttcaat aaactggcct 3500701 ttgaccttgt ttaatgtatt tctatatgaa aaagcttgag tttctgcctc tatcattgga 3500761 tcttccggat tgatcaaaaa tggcttctca gtactggtca ctattttcgc cttgtttatt 3500821 tgatgaagat gcaacaaggg aatataaaga taattgcagc catcaaaaat aacaaaaata 3500881 tcctgtccga tatctatgag ggtgccgaca aaccttgtat ctcctgaaat gacaacctca 3500941 acatctgtgt taaggaattg attcaaacct ttcacgattc tcctccttta actgaaaaag 3501001 ggcatcactt tatctgatgc tcctccatta tctattaaaa tttacgtttc cagtgatagt 3501061 ctatcgttct gacaatcgtt tcatagctat aatcttcctt ttgttttcct gaacttttta 3501121 ttgaacttga atagcctggt gatcttgatg attgataatc tgaagatctt ggtgatcgtt 3501181 tagatgattt tgatgattga taatctgaag attttaatga tcgtttagat gattttgaag 3501241 aactttttga acgtgacgaa cggccagatt tggatgattg ataatccgaa gattttagtg 3501301 atcgtttaga tgattttgaa gaactttttg aacgtgacga acgaccagat ttggatgatt 3501361 gatcatctga agattttagt gatcgtttag atgattttga tgagctatat gattttgaag 3501421 aaatgaacga attgctgtcc ttatcattat tgtcttcctg gttttgttca tttttttgat 3501481 cctctttttt gtacgaccct tttggaccta agctgatgct ttttatgtga aaaggataga 3501541 tgcgaagcac ctcttgattt ttcactatag tataatggcc gtcggcatta tctacaagga 3501601 taccctcaat ggcttccgga cctccacgat taattgaaac ccatttatga gtcagactct 3501661 taaaaacctc gcttaaatca tcagcttcca aaactccaac tggcgtctgc tcttctattt 3501721 tcaaatcagg ctcgtgttta cttatacttt tgatgtgatg gatattaaaa tacactaccc 3501781 catcctcatt tgtgtttaac gcagcgtaat catctcccag ccagaccaat cttccttttt 3501841 tagattccgg acccccttgg ttaaattgaa ctgattggtt tattaaatgt ccgattaagc 3501901 tatgaaaatc atcagcatcg agcatttcct cagtctcaat tgttgtggtg ctattattgg 3501961 tatcctcagt aatacttttc acatgctcca actgataata aattattttt ttttcagctt 3502021 gtaaagctat ataatctgat tttacagctg ttaattttcc ttttttagat tccggacctc 3502081 cacgatatac agtaacaatt ttatctttca ttgagtgcaa aaagttataa tacgatattt 3502141 cattatttga atgatatttc attctcctct tgctcattca aattcctcct agtcacttat 3502201 acatagatga taaacatact gcatatatac gtgtcacatt tatttgttga actaattcaa 3502261 tagcctaatt gtcgcttttt ccgcgaatac ccattttcac gcattcataa aatacttaaa 3502321 tgatctttga ggtattgtga acggttttta atatactcgc agatcacatc cggctcacgg 3502381 tcaaaacgct caatatcatt ctttttatac gggtccatga ggacaaacgg cctaatccgt 3502441 tcatacatcg ccatgatttt cggttccata tattctattg taaaaagaga ttggagcgtt 3502501 ttttctaaca ggcgcttgta ggacttgcga aactcggatt catccaatat ccgggcggtt 3502561 agtgtattaa atccttgaat tcttacataa tcggcagcca tccgctctcc atggatatcc 3502621 ctgccccaag tcgcatcata atcccaagga atcacctcaa ataatccggt ttccccgctt 3502681 ctgtataatg cgtagttgtg gacaaacccg tcatagttcg aggtgaatac aataccagca 3502741 agccagcgca aatacttatc gacatccacg tgttttgtca cttctgactt aaactgagct 3502801 ttagggaccg tattaatttt aaaaatcata tcttgtaaat aaaaatcatc ttcctcagtc 3502861 cctgttttct tttcatatcc aagctccagc gatgttttcg tttccctttc taaatcgctc 3502921 atcagagaaa agttggcatc atcatccacc gcataaaaaa tcgcgccatc agccagcttc 3502981 cttttcgcca aataatattc atctacggat tcaagttcaa gataaacccc ttcattcttc 3503041 ccattcatct ttacaaacgc aaactctgcc tttggagaca gtgtccctag ctccgagaaa 3503101 aaatccagag acaatttgtt tctcatcaag gaagggtctt tatactccgc atttaagtga 3503161 atctctcgcg cgccgcggaa tgttttcggc tgataaaagg aaatatggta tgacttcttt 3503221 ttgaagtctc tgatatgtga tccccgataa gcgatatcaa tatccagcct tttttgattt 3503281 accttcatca cagctggcac cggatcatcg tcccatatat ccttttttaa ttcacgcaag 3503341 tcttttggat gaacaaacag ctgataaagc ggtaaattgg attgattctt catccataat 3503401 cctccttaca aattttaggc ttttattttt ataagatctc agcggaacac ttatacactt 3503461 tttaaaaccg cgcgtactat gagggtagta aggatcttca tccttaacat atttttaaaa 3503521 ggaggatttc aaattgggcc actattccca ttctgacatc gaagaagcgg tgaaatccgc 3503581 aaaaaaagaa ggtttaaagg attatttata ccaagagcct catggaaaaa aacgcagtca 3503641 taaaaagtcg caccgcactc acaaaaaatc tcgcagccat aaaaaatcat actgctctca 3503701 caaaaaatct cgcagtcaca aaaaatcatt ctgttctcac aaaaaatctc gcagccacaa 3503761 aaaatcatac tgctctcaca agaaatctcg cagccacaaa aaatcgtacc gttctcacaa 3503821 aaaatctcgc agctataaaa aatcttaccg ttcttacaaa aaatctcgta gctataaaaa 3503881 atcttgccgt tcttacaaaa aatctcgcag ctacaaaaag tcttactgtt ctcacaagaa 3503941 aaaatctcgc agctataaga agtcatgccg cacacacaaa aaatcttatc gttcccataa 3504001 gaaatactac aaaaaaccgc accaccactg cgacgactac aaaagacacg atgattatga 3504061 cagcaaaaaa gaatactgga aagacggcaa ttgctgggta gtcaaaaaga aatacaaata 3504121 atctaagttt tcattgtttc aataggctgc cggcggaggt acggaagcct atttttttat 3504181 ttgccctgta ttagatatat gtcatgacat aacatatgca acccgcatca tttggtttcc 3504241 tttaaaccat ttcgttataa tcaaggtatc ctaacgataa aggcggttgt tgctatgtac 3504301 atatttcaag ctgatcagct tagtgccaaa gacacataca agctattgtc aggtaccgtt 3504361 attccccgcc ccattgcatt tgtgacaaca ctttcttcag gaggagcggt aaatgccgcg 3504421 cctttcagtt tttataacgt cgtcagctca gatcctccgc ttctcagtat ttctgttaac 3504481 aggacggaag gacgccaaaa agatacagca cgaaacgcag tggagaacgg agaatttgtc 3504541 gttcatgtca gtgatgaagc catcattgaa gatatcaatg aaacagctgc aagcttaagg 3504601 ccggatgaaa gcgagcttac acgcacctcg cttcatcctg ttgaaagcaa agctgtttca 3504661 gttcccggca ttaaggaagc ccgcgttcgc tttgagtgca aattagagcg gcatattacc 3504721 tttgacaatg atcaaggcat cactacagca gatctgctca tcggaagagt tgtctgcttc 3504781 cacctagatg aaaaggtgta tgatgcagaa aagggatata ttttaacgga tgaattaaag 3504841 cctgcctcac gattggcggg aaatcactat gccaagctgg gggaagaatt cacactgatt 3504901 cgtcccagct gaagagaagg actatttaaa tagaagaaac tagtcaaaaa gaccttatga 3504961 ttacaaaata tcgcctgtaa ataactgaaa aaatatcaaa aaaaagaaca cccagagcaa 3505021 gctcggggtg ttcttttatg aaacgttttt cctttttctt cgtataaagg tagattagga 3505081 ggaattggaa tgacaaactt ttggatttta atgctgatcg ctattaccat cagtctcgcc 3505141 tctcaatttt ttataaagaa aaaatacggt attgataaat ccggctggcg atataagcat 3505201 gtcagcaata cacacaaatg gatcgaaatc actttactta ttttgtttgt gttttcactc 3505261 tccttttttc cagttgaata tttgcttctt ttatttttta ttgtgattga ctcaatacgt 3505321 atttttatgg agtggcatta tagacctgaa gataaacagt atatgtacca cattgtagag 3505381 gtctccctta tgtttatgct tttgatttat gtttgtaccc tatagttatt taaatcccca 3505441 cagccgctcc gtctccccga ggatcggctc cgccttggag aaagccttct tcatcaactt 3505501 tgattgcagc cgcttgtccc atcagcggat catagtcacc gacaacctcc acgagatgcc 3505561 cgctgtcttt cagtttttgg attgttttgt ctgtgaatct gccctcgact ctgagacctt 3505621 cgtattcctc tccccacgtt ctgccccata cccagcgcgg ttcgctgatt gcctgctgtg 3505681 gatgcattcc gtagtccagc attcgggtaa tgatggccgt ctgggtctgc ggctggcctt 3505741 cgccgccttg tgtgccgtac agaatttttg gctttccgcc tttacagacc atagccggca 3505801 tcaacgtatg gaaggtgcgc tttctcggtt caagcgtgtt gacatgattt tcatccagtg 3505861 agaaaaacga tccgcggttt tgcagtaata tgcctgtatc accggcagtg actgccgagc 3505921 caaattcaaa gtacaggctt tgaatgaatg acactgcgtt gccatccgca tcgattacgg 3505981 ccgcatatgc cgtatcactt cccaccggcc tgctttctgc cggtattgcg agatagccga 3506041 tttcttctgc caattgtttt gcataacgtt tgtccaaaag cctttcaagc ggaatgtctg 3506101 caaacgccgg atcagtcagg acggcatccc gatctagaaa actctttttc aatgcctcca 3506161 caagcacgtg ataatactca aatgaaccgt gttcgatttg ggtgaaatca tagttttcca 3506221 aaatgttcag tgttaataaa ccggtaaatc cctgagaatt cggcggcgcc tgatacacac 3506281 tgtatcctcg ataatcactt gatacaggcg ctgcccactc accccgatgc gctttaaaat 3506341 catcgattgt catgtaactg ccgttattct gtaaatgtga gacaatccgc tgagcgagat 3506401 ctccttcata aaatgcgctt cttccttttt cagcaatcaa gttcagactg tctgcaagct 3506461 ctttttgcac aaaccgctct cccgggacag gtgctttgcc ccttctcgtg aagatgtcag 3506521 ccgtgtaagg cgtggaagcc agcagttcaa tattcttttc tgtgtgacga cactgatcag 3506581 ctgatacagg aaacccattt tgggcataat cgcgtgcggg ctccaataca tctgcaagag 3506641 acagacgccc gtactccttc aggaccgcat cccagctatc aaccattccc ggcacggtaa 3506701 tagcactgtc aattccccgc agcggaatcg cgctttttcc cttatataca tctctcgtta 3506761 cgttttttcc tgaacggccg ctgccattgt agacttttac tgcctttgtt tcctggtgaa 3506821 aggtcagcca aaaggaatcc ccgccaagtc cggtcatatg cgggtacaca accgcaagac 3506881 aagcactcac cgcaacagcg gcgtcaaacg cgttgcctcc cttatccagt atgcggtttc 3506941 cggcttgaga agcgagataa tgcggactga cgaccatttg ctttgtaccg atgacagatt 3507001 tgttcatcac aagtcccctt ttttaagaaa ttttcttcag tatagggagc ctgatttttc 3507061 acatctactg atccggcaga aaaactgacg aactttcttc ttttcgcaaa taataagata 3507121 ttttcgcatt catttcgaaa acaaatgaaa aattattatt tctatacgta acttttatga 3507181 taaaatgatt gctaaaaggc tacgaaagca ggtggagcaa ttgagtcatg aatatcaaat 3507241 ccccaacctt gtacttgatg agactgataa acaaattctc acgattttgc atgaagaagg 3507301 cagaatttct tatacggatc ttggcaaaag agtcgatttg tcacgggtcg ccgttcaggc 3507361 ccgtatcaac caattaattg aagccggtgt tattgaaaaa ttcaccgctg tcatcaatcc 3507421 cgctaaaatc ggcatccatg tttccgtgtt tttcaatgtc gaggtagaac cgcaattttt 3507481 agaagaggtc gctcttaagc ttgaggaaga gcctgcggtc accagccttt atcacatgac 3507541 aggcccgagc aagctgcata tgcatgggat ctttaccaac gatcaagaaa tggaagaatt 3507601 cttaacaaaa cggctgtatc cattgcgagg cgtcgtcagt gttgattgcc agatgctgat 3507661 caaacgatac aaaagccgta tgggaatgaa gctgtaaagg agagaaacaa atgaaaaacc 3507721 atccttatcg ggatatgacg gccgcaatgg ttcgcaccgg catattaggg ttcggcggcg 3507781 gaccttccgt gattccgctg atccgccatg aagcggtcaa taaatataaa tggattgacg 3507841 atgatgaatt cggagaaata ttagcaatcg ctaatgcgct tcccggaccg attgccacca 3507901 aaatggctgc ttatctgggc tttaagctaa aaggcacatt aggtgcaatt gtggcgatcc 3507961 tcgcccacat tctgcctaca tgtcttgcga tggtgggctt gtttgcggct gtaaatgtgt 3508021 taagccattc agcaattgtt gcaggtatga ttggtgccgt cacgccggta attgcggtca 3508081 tgctcggaat catggcgtac gagtttggcc aaaaagcgct taaaggtttc ggctgggtta 3508141 ccggcatcct gttttttatc atcgctttta tcggcctgca aactttacag attaatcccg 3508201 gcctggtcat tatcattttc ttagcttacg gggcgtttca ttttaaactg aaagacaaaa 3508261 tcacaaataa acattcaaaa gataaaggaa tgtcagcctc atgatatcga tctatttatt 3508321 tatggcgttt tttatcgcaa acctactggg atatggcggc ggacctgcgt ctatcccgct 3508381 aatgtttgaa gaagtcgtaa acagatacag ctggctctca aacgatcaat tctcaaatat 3508441 gctcgcactt gcgaacgcat tgccgggccc gatcgccacg aaaatcgctg cgtatgtcgg 3508501 ctacagcgca ggcgggtggc ccggcttcct aattgccctg atcgcaaccg tcgtaccgtc 3508561 ggcgctcgca ttgatcgtcc tgctgcgcat catccagcgc ttccgccaat cacctgtcat 3508621 caaaggcatg acgctgtccg tccagcctgt catcgcggtc atgatgctca ttcttacctg 3508681 gcaaatcggc gcagacggca tcaaagcgat cggctgggtc caatcgatcg tgattacggg 3508741 aatttcgctc cttgccatga caaaattcaa aatgcatccg gcatttttga ttattgcggc 3508801 gtttttatat gggggccttg tgatccctta tttatagaaa aaagcacctg gacaggtgct 3508861 tttttatttt agcccagaaa tgccgtttga tatgacagct gtttcttctc ctgcgtcact 3508921 cttgatcatg tgcttgactt gcagcgtggt tcctgccatt ctcacagatt gcttcaactg 3508981 ggacgaattg gtttcaactt gtatccaaac aggaggctgg accttccaaa ataaatagag 3509041 tgcaagaatc agcaagccag caatgaccga cagcaaaaac ttcatatcgc atcgcttctt 3509101 ttcagtaagc ggctcgcagc ggacagcgcc tgatgatcac gaagaatatc gcctggacga 3509161 ttgccttctc ccagcacata gcctttaaag gacattccca taaaatgaaa aatatgttcg 3509221 aattgctgaa tcagcggcag cccttttatt tttggattgt ctccgcccac tgctattaca 3509281 tatgcctgtt tcactgacat ttgctgttta aaatcaggaa atctcggatc tctcaacgtc 3509341 tgtgaccagc gatcaataaa cagctttaat gtccctgaca tgccaaacca ataaattggg 3509401 gtggcgaata taagaatatg gcactgcaat atccgttcaa tgatagaatc gtagtcatct 3509461 tgaacaggac gaaagccgcc ttgggcgtga cgcagatctt caattggttg aattggatat 3509521 ttctgcaaat aaatgtgctc cgcatcgaat ccttgaacag ccttctccgc aagaacatcc 3509581 gtatttccgc cagaccgagt tccgccgtta ataaccgcaa ttttcatgat gcatctgctc 3509641 ctttgtttac gaatgatttt cttcatcata taatggattc atcaatcaat acagatgatt 3509701 atttcgatta atccaatcgc taaaaccgat ttagaaagga agagaacaag tggaattgaa 3509761 gcagctgatc acctttatta cggcggctga acatgtaaac ttcaccctaa ccgccaaaat 3509821 gcttaattat gcacaatcaa gcgttacctc tcagatcaaa tcacttgaag aagaaatcgg 3509881 aacgccttta tttgaacggc tcggcaagcg gcttatcttg acagaagcag gaaaaacgtt 3509941 caaatcttat gcacagaaga tcattgcgtt aacagaagaa gcgaaaatgg ccacaaatca 3510001 agtaagagaa acaaccggaa ccttaaaaat cggggcgacg gaaagccagt gcacataccg 3510061 cctgccccct atcataaaag aatttaaaca ggcttttccc caagtaaagc tcatattcaa 3510121 accatatatc tccaatgaac aagcgaaaga acagctctta cagggccagc ttgatatcac 3510181 cttcatcttg gatgtaaacc ggatggaaga cgcactgcac gttgaatctt tgattcagga 3510241 tgagatcaaa atggtggctg ctaatgacca tccttttcct gcggatttac cagtaacatt 3510301 gaaggatctt caaaacgaaa ctcttctgct gacagaggac ggctgctcgt accgcacgct 3510361 ctttgagaac aatttgcatg actccggtat ctatcctaac aaattggaat tcgtcagcat 3510421 agaagccatc aaacaatgcg tgatggccgg acttgggatt ggaatcttgc ctgaaatgac 3510481 agtaaaagat gatattgcag caggccggat gaaagaactc aattggcaga gcgattgccc 3510541 cgttttcact caattagcat ggcataagga caagtggatg tctgcgccat taaaggcttt 3510601 tatcgatttg acacggaaaa cattcaaata aaacctctcc acaaggacga caaggttttt 3510661 gagaccaggg cacacacata caaaaaaaac acttgatgac ttagagcccc aagtgttaca 3510721 cgtgattttt ctgataaaac gttcgcaaaa catgcgtctc aaggtcagcc aggcggacag 3510781 ggatcggcag cctgctttct tgattgatca agctcatcgt gatctgatag ctgctgtcta 3510841 aatcaatata attaccgcaa gacaagaaaa taggcttcac gtcccgccgc gttcgcagcg 3510901 cccgtccata tacctcgccg tcaatgataa tatcggtgta tgcgcctact tcaatttcag 3510961 gcgtcacgaa atcgcagcct ttgattttga gataggtttt cgctatccca atcgtcggct 3511021 tgcccagaaa aaaagccgca tgggtggcaa cgcccatatg attgtaatgc agatatccgt 3511081 tgccatcaaa caagaagaca tccggctccg tctccagctt tttcgccgcc tcgatgatca 3511141 agggcagctc gcgaaacgca agaaaaccgg aaacatacgg cacgctgatt ctccccatgc 3511201 tgtgcacttt ttcaatgact tcttttgtat cagcgtcaat tacgataata cagcacactc 3511261 cgtatggttc tccatcctgc tcccaatagg ccaggtcgac gcctgcgcag gtgttgatgg 3511321 agtctggatg gatcgtgggg gataggttga tacgattttt aaggttaaat tgcacttgta 3511381 aaaagtcttg ttcctttttc atatcaaatt tatgcacatc aaataccttc ataacgattg 3511441 ctcactctcg acctaaatta atgtgagtct ctcttctcga ttctagtatt tcaaaatgag 3511501 gactatctgt atctatctcg tacttattta atagattgcc ttcttcatcc caattctttt 3511561 cagaaattag tatggaatgc tcatactgtt gctcactttt tttcctgcca ttttcaaacc 3511621 aaattatgct tataccgtgc aattgcccat atcggtattc tttttcactt tttttattcc 3511681 cgttttcata aaattcacat gttaaaccat gggccagacc attcttatat ttagtaaaat 3511741 agatgatttg accatttgga tataattcgt aagccagccc tgtaaacggc tggccatttt 3511801 cgtcttcagg attatctaaa atctcatcac ttaccgaaga gaaccataaa tcctcaaagt 3511861 ccactccctt ttcttttata ctcttcatat catattcatt ttccatactt taaagcctcc 3511921 ggtatataat ttgtattttg agttatatat tcacaatgtg gacatctagg cattgggaca 3511981 ccttctggca tctttttatt tattttccta gcacttacta catataccat taaatctttt 3512041 aaatccgcat caggtctttg aagtaacgct tcatttagag cattaacttc ggcatgagaa 3512101 cccgcccctg acgtctttat ataaccttct ttaagttctg taggcatatt tacaattcta 3512161 tcatgaataa gtggatgtag taccttaggt ggcttcccat ctatattgtt tattccaaaa 3512221 taataattgc ctgttttttt gtccaataca ccagctaccg cagggcctct ttgtttttta 3512281 gttagaccag aagatttaat tctactaagt tcgtttagta cttctgccct tagatttatt 3512341 cgatggtgaa gatcttcttt agacaataca ccatgcttat ttcttaaata ttgaagccta 3512401 gtttgttttt cttcagtagt cttagcaata ttgctaataa ggctttcatt actcacttta 3512461 ttgacatatg gagcattttt ttggtacaac cgatcaaagt agtgtgccaa tcctgctcca 3512521 ccaataatag taatagcttc cagcgcccct tgcttccgct tctcctcaga cactttgttt 3512581 ccgaacatat cccggcctgt gacagcttct gagaatccgt ttgacgcaac aaggccgtat 3512641 gcgcccattt ctgtcatttt gagaatgtct aaggatttgc ctgttttgta ggcgtctaat 3512701 gcgtgttcag cagcgatagc tgcttttccg gttttgtaga tggcttttcc gcctttgaag 3512761 gcccggcctg cccagccgac gactggtatg aatccggcag cggccatagc tcctgctgtc 3512821 acacgctccg cggtggagag tttttctccg gtaaccggat caacgccttc ggttgctctt 3512881 ttataatcat aatagccagt gacttctcca gtaaagttgc aaactccatc ccatgttttt 3512941 tcgtaccacg gtttgtttgc ttcttcctcg gctttttcct ggagccgtct tgcttctgct 3513001 tgctgggttt ttgcatcgat ataggttgtt ccttgatttt ctacttcaat gacgcttttg 3513061 tagacttcat tgctgtggaa ggcttttttg tcatagtaca taggggatgc gctcttccca 3513121 ttgctggtgg cctgcatgag aacagaatat ttggtgagca ctgcgttgtc cagagattct 3513181 aaattttgat attcagtggt cagggattca tcaagcttat cgacagctgt gattgtatca 3513241 cgtctgattt tttgggcatc gcccatctta tctgcatagt cgtcaagcgt gtacatgtcg 3513301 agatcaataa tatcgctgat gcctgacaaa atagaatcga tttcttcttt atgagcggag 3513361 acaatctctg aggctttcag gtctccattg ggcagctcat gatccaaaaa agaagtttcc 3513421 acatatgaat cattcagttc ttgatcttta atatctcctg aaatgccgtt taaaaacgca 3513481 atttgagcag agacaagcgt cagccagctg tctacgattt ctgcctgtcc ctgaaaaaaa 3513541 tctttaatat tgtccgcgcc atttccttta aaattatcgc ctaaatcggc aactccctga 3513601 aacgcttttt tcagcgtatt cagctgctct tcaagcgtct catattgctt ttttctgctc 3513661 ttcgcttctt cgattaaaga ttttgattca aatactttac tcatcgcact gccctttctg 3513721 ttctatttta ccgctatcgc ctcgtcctgc tctttgagtg aatctacgtt atcctttgta 3513781 tcctcgatat ttttctgtac cgcttttttg taatctccga gcatggtttt gatgttctcc 3513841 tcacgctcat ggtatttttt cgtataatcg aggctgtttt ttccgttgga tcctgcggcg 3513901 ccgattgata cgtcagcaag cgcatctttg acagaatcta atgttttgat gactgtgtcg 3513961 tacttcagct taatttctga cataaaaaaa gatcaccacc attttagttt actaattgta 3514021 tttccgactt cttccgcgaa ctcttctccc tttttaagaa gatctgctgc accatttgct 3514081 atgaacaatt ccgatgcata tttagcttta tcccattcaa gatcaaaaat tttcccgtta 3514141 atcgaagcca tatactcgtt atatttatca ttcacaatct tagatgcttc cgatttcgcc 3514201 tcttctcttc ccttgtcgaa atcatcggct tttgttcccg tccaatgctt gcccaattcc 3514261 ggtttcacaa tttctttgat ttcagtgatt gcctcttctt gcagtgtgtc tatgtccttt 3514321 tttgcttttt tcagcttttc gatcttgtct tccacgtctg aaatttttcc gttgagcgaa 3514381 cttttgatat ccgctagcat actttcataa cccatctgaa tcacctctta atactcaaaa 3514441 agtcgtatgg aggggctgat gaagatagac ttttccatac tttatttcca tatattatat 3514501 tttaaaatag ccagaaggcg gcttaaatag ggtaaatggc ttaatttagg catataacgc 3514561 tcttgaaatg taggtatttg atcttgtttt tgttcgttat acagctaata aaagcgtttt 3514621 ataaaatgaa atcacctaat gtcatagtta taaaggcact tgaaagaggc agatgttgtt 3514681 gatctgcctc tttcggcgct gagcttattg ttcatgttta tgttcttcat ctggtcggcc 3514741 atgtctgatt ttgtcatttg gcttctatta ttcccccctt ctgacccttt ggatcaaaag 3514801 cttgtattag ctgcagtccc agttgtacag aacgtttgaa aagtcttttt tccttagatc 3514861 ttcaggtgtg atgaaaaaat tggcgatgcc gacgtctccc cacattgaat cgatatcatc 3514921 gtctgaatca atttgtaaca gcatgatggt gtgttcttta tatgcgtatt cccggggatc 3514981 atgctgggta aaagaagcgt atccgccaat tttatggcca aatccgtttt cagccagttc 3515041 attataaatg tcttcttcat cctcgccgaa ctgaccaaag aactccattg tttccatgcc 3515101 cgtatactgc tcaaattgaa aatctgtagg cagcacccat tccgaagatt tcacaggctc 3515161 gactgccgct tctgataaaa tcggaaaatc acattcgcct gtgccaataa atgaaaaatc 3515221 agaaacaagc tcgtcatcgt tttctacgat attttcaaaa tagatcactc tgaaattctt 3515281 ttgttcacat cgatcgtcaa aattcaatcc atagacgtca tcatgaacag aaatgtagaa 3515341 ctgcaggata cctgaagaag ggtagccgtc aagctgggga atgtgcgaga aattaatctg 3515401 cgccagaagt ttcatcggct gtccattttc gtcagtcgga tatgtttcat gcttggggaa 3515461 atagggatca ccggcaattt tgctgtcata tcgtcctgtt ttcccctttc tcacattcag 3515521 tttcacgtat tctttcgctg atttctccag caagtcgcgg tacggtctca ttttttcggg 3515581 cagatgattc atcagattct ctccttttcc ggcatctcca aggttttatt ttctggtttt 3515641 cttctaatgt ttttcaaacg aatgtttaaa gaagccctac ttctgcataa ttttccaaac 3515701 aatagttaaa tagtagcaaa tgtattcagc accccgcaat agatgaaaaa aagactggtg 3515761 cgcaaccagc ctttcttttt catctattga attgcacctg acggaacaac cgccttccgt 3515821 ccgacagaat aatactccac tcctgcagcc aaagcctcat ccaatgtgta gcagtttctg 3515881 ccgtcaaata tgagcggcgt ttccatcaaa tcctgataag ccgctaacgg gaattgttta 3515941 atgtcagccc agtcggttaa aatcatgacg gcgtcagacc ctttgacagc ttcctcgatc 3516001 gtctctttat attcaacagc ttgcgggaga acatgctttg catggctaac tgcaatggga 3516061 tcgtaggctc tgatacgggc gtcgagcgca gcgagacggt ctgcaataac aattgacggc 3516121 gcttctctca tatcgtcggt attcggttta aatgacaggc ctaaaagggc aatcgttttt 3516181 cccgtcaccc caccgagcct gttcagcgct ttatcaacca gcatcgcctg ctgattgttg 3516241 ttgactttga taacggattt cagcagttca aaatcatgct cgacattgcc ggcaatttgc 3516301 acgagggcgt ttgtgtcctt tggaaaacaa gagccgccgt agcctatgcc cgcttttaaa 3516361 aactggctcc cgatccgctt atcctgtccc atcccgtatg cgactgcttc aatatcggcg 3516421 ccgacctttt cacatatatt cgaaatttcg tttataaaac tgatcttagt ggccagaaaa 3516481 gcatttgagg catatttgat catctcggcg cttctgatat ccgtttggta aatcgggatt 3516541 tgaaacggac ggaagagctc ctccagcgta tttgctgttt tctcatcggc cgtcccgatc 3516601 acgatcctgt caccatgaaa ggtatcatag atcgccgacc cctcacgcaa aaattccgga 3516661 ttggatgcga ccgaaatact gacaggctcc gctagatgtt cagtaatcag tccattaatc 3516721 aaatcgtttg tcccaacggg cactgtgctt ttcgttacca cgactgtatc tcgtttgaca 3516781 tgctttgcga tgcgtttggc cgcatctgta atttgctcca gattggcgtg cccgtcgctt 3516841 ttctgcggtg tgccgaccgc tataaaaatg atgtctgcct gtgccaagcc tttctcatag 3516901 ctcgtttcaa agttcagccg tccatcagct gtattttttc tcatcagctc ttcaagacct 3516961 ggttcaaata tgggggaaat gccctttctc atttcatcaa tcttgtgagc gtcaatatca 3517021 atgcaggtta catgatgtcc aatctcagaa agagaaacac ctgtcacaag accgacatag 3517081 cctgttccga tgactgttat attcattgtt tccctccaac agttaaattg ctgctttgca 3517141 gcttccgtaa tatcgtatga gaacatccta tcatgaatgc gaatgatctc ccgcatagcc 3517201 tgtcgggtac agcctgtaca gatttctgaa atgtgattca accatacaat acactattat 3517261 atcgctctca aaaagaaagt ggtgaaatga gaatcggctg ttaaaaaaaa ccaaacaatt 3517321 ttcttctttt gaccggctgc ggaggctgtc tgaagatggt ctgattccgc aggagaagct 3517381 ctgcattttc cgtcagcata taaggaagtt ccgagccgaa ttctttctct agaacataaa 3517441 gagcctcttg agtgtgaaaa tttctcgttt tcacattatg ggcatctgag gctacgaaat 3517501 ggatcaaatt ggcttcaacc agccggagag aaaatgcttt cagctgcttg ccgaagatcc 3517561 ccgcaagact tcctgaagta atctgagatg ctgctccttt ttccacaaga tgatacagca 3517621 aggacgggtt ttcgcgaatt tccctgttgc gttcaggatg ggcgataacc ggaatatatc 3517681 ctttcagctg caaatcataa aaaagctgct ccgcatatcg gggaacgtga tcaaacggaa 3517741 actcaatcaa gatgtatttt gtatcattca gcgaaagcag ctgacgtttg gcaaggtctt 3517801 gttccacctc gccgtagatt ctgatttcct gtcccggaag cacatgtaaa ggaatgtctt 3517861 ctttgattaa acgtttgttt aactgatctg ctgcttctct gactgcggct ggctcgtttt 3517921 tatacacacc gttgttatga tgaggtgtcg caatgatcgt ccggattccc tgacgaacag 3517981 ctgctcttgc catttctatg ctgtcggccg aatcacctgc cccgtcatcc attgcgggaa 3518041 gaatgtgaca gtgaatatcg atcatgtcct agcccccttt tttcgcaaaa ataaataacg 3518101 ggcacgatgc acgttattta tttttgcatg aaattgtcct tggttccgta atatccgtat 3518161 tcagagtgct tcgaaagctt tttgccgttc ataatcgccc caaggagctt gcttttgcac 3518221 gttgcaagcg cctctttcgc ttttgcggct tgttcttttt ctgttttccc gcttgaaata 3518281 accagaacag aaccgtctgc cacgttgcct aaaatctgtg catctgctac ggcaagaata 3518341 ggcggcgtat caaaaatgac catatcatat gccgcacacg cttcgtatgc aagctccttc 3518401 atccacttcg aggagagaag ctcggccggg tttggcggga tcgggccgct cgtcagcacg 3518461 tcaagatgtt tttcattcga tgcttgtaca gcctgctcca tagagctttt ctttaataaa 3518521 acagatgtta agccaaccgt attttcaaga aaaaaagccg tatgtactgt tggttttcgc 3518581 aaatcagcat caatcaggag cacttttttt ccctgttggg cgaatacgac agccaggttg 3518641 gcggccgttg ttgattttcc ttcccccgga caagccgatg taatcatgac tgatttcatt 3518701 tgccggtcca ctgaagcaaa ttctatattc gtgcgaatcg tccgatattg ttcagagttc 3518761 aaggatttcg gctctgtcat tgcaatgaca tttctctgca tccgcgagcc tctgtttttt 3518821 ctaagcgcca aaatgtccac tccccgtttt ttcagattgg aaaccctgta aggtctttgc 3518881 tgttttctgc tcattcgcaa tggtggaaac tgtccctaaa acaggtatgt ccagcaagga 3518941 ttcgagctgc tcttccgatt tgatcgtatt atccaaatgc tcaagcagga aggccagtcc 3519001 gatgcttccc gccaatccgg ccgcaaacgc gatggcaatg tttagtagcg gctttggcga 3519061 tacaggggac gggtgttctg aaacctcggc ttttgacaga atgctgacat tgtcaacatt 3519121 cataatggat gtgattttgt cttgaaaaac agatgctata gtattggcaa tatgagccgc 3519181 tgtttccgcg ttttcatccc tgactgatat gttgaccact tgggagtcct gttcgctgga 3519241 tacggtaatt ttgtcattca gttcttggga tgtcatcgac aggcccattt ctttaatgac 3519301 ttcatctaag atggcagggc tcttaatgat gacattgtac gtattgatta actgaagatt 3519361 ggtttggaca tcgttaaatt ggacttcttt tcgttcattt ttcgattggt tgaccagaat 3519421 ctgagttgaa ttttcataga tgggtgtaag tgcgaagaaa ctaatgagtc cgccggcagc 3519481 agtggcagcc gcggttacaa tcataatcaa aagtatgcgt tttgttaacg ttgataatat 3519541 ctcttttaag cttgtagatt ctcccatgat acctccaaat ctcttataac atccttttcc 3519601 atctacgatt atacaacgtt gaaaccgcat ttctccagct tttcacgtga cataattcga 3519661 cattttttta caatgcgtta tgttagtact ttttatgtaa gcgctatatt tactgtgttg 3519721 acagtgctgt ctcattttct cttattcggg cagtcacgtt ctctcgcata aaaaaatccc 3519781 gctaaaggcg tgcgggattt ttatgttgca tatccatttt taatatgaga aatcaaattt 3519841 tcaagcattt ccttcgtcgt catctcagat gactgctcac caatttcatg tgcatgcatc 3519901 aaaattttca gaaattcttc ttgattcaat ttcttttcac tcatcttttt tttcctttca 3519961 gcttccatta agttgaaaac acgattatta tatgatgctg gttatcaatt tgcaatctct 3520021 aatacatcat tcgacacatc ctatttttta tgtccttttt taggaaaaac tttttaaggc 3520081 cgatgtgttg cgatataata gagaaattgg atctttttat tacgtgactc ggttaggagc 3520141 gataatcatg cttcagaata tgatttccaa agacgatgtg ctggcatctg ctgaacagtt 3520201 aaaagaactt cttccttaca atgaggaaaa tgttcagctg atcaaaaaag cccttatttt 3520261 atatcggcag gattcagtct atcgtttaca agcagtgagt ccgacggaag ttacggctta 3520321 cgtgcaggat gttgtgcctg tgcgggtcac attgaacttg tttgtcatag tcaaaagcgg 3520381 ctgttcatgt ccgtccggaa gaatctgccg ccatatgctg gctgtgtttt tatatgtata 3520441 tgcaatgttc gagcgagtgg gtacttttac agagtattgg ctggagaggg aaaagcttga 3520501 ggaaagcaaa gagctcgtcc gccgccagtt tcaggaaaag gtgctgccta atgaagaatc 3520561 actttcaagc tggcttgctt tttttgattc agagttttct ctctggcagg cacgtacgcc 3520621 agaaggcagc caaaacatgc agggcctcta ttacggctac ctgtccgcat taaaaaaaca 3520681 tgcgccgaac aagccggagc tgaaaagcct gtatcagatt cattccgcga ttgcggtttg 3520741 gcttcgcatg ttcacattga ttgaagcggg caagctaaac cccgaacaag atttttattc 3520801 cctcaatccg tacgttgaac agctgatgga tacaatctac agctctattg ataaattaaa 3520861 aacgtacgcg ctgtcttttg cgcttgatcc gtttttggat aaaacaccgg atgttatccg 3520921 gcatttgctg ttgaaagaag aaattttcca atatgaacgc atccgcgtct tcggtgaaat 3520981 ttggagtgcg ctgctgtcgc ggccaaaatg ggtggcacgc gaacaggaga tattgaaaaa 3521041 agaagcagga cggcgttttt ctcccgaatt gcaattcggg cgcctgcatt tggaattcct 3521101 gcaaaaaaat gatgacgtta tttttgagga agcggatcaa ttcccgccgg aagcgctccc 3521161 ttatacattc caatggctga gtgaaatgac tgccaagaag gactggaaac ggcttaaaac 3521221 atggtaccag caaattgaac caattgcgat gggttatacg aagctggata agccgtttaa 3521281 agagattcgc gatgtgatcg gcgagctgtt ccttctgttg aatgcctatg tgcagcaaac 3521341 caatgatcaa gcgctgtttg agcgctttgc cgcgggctgt ctgccgtata cgttcacaga 3521401 atacagccat catttatatg aaaaaaaacg ctatgccgag tggattgaaa ttcatagcct 3521461 tgtcggcttt tccatcaatg aaatggataa aatgatgctc aaggaaattg cagcgagcga 3521521 ccctgaggcg cttataccgg cttaccatag agaagtggct tttttcattg atcagaagaa 3521581 ccgtagctcg tacaaggaag ccgcccggta tttgaaaaaa ttgcgcaccc tgtacaaaaa 3521641 agcgaaaaag cagaaggtgt gggagcggta tattcagctg ctgagctcgc attacaagcg 3521701 cctgcgtgcg cttcaagaag aactgcagaa aggaaagttg attgatggcg agtcttaaag 3521761 aaattctcat ccacgtcgaa caaatggaag atgggtcatt tacgctctca gcctttgatg 3521821 agaatgagca gcctcttccc tacagccata tgaaaaagca tttgttccaa tggcatgaat 3521881 cctcatttta cggaaccttt ctagaggatg tcagcttcat cgggacgact gctgtccttc 3521941 tatctccatg gatgactgta gagcttctcg gcaaaaactc gttcaactca ttcagctccg 3522001 tgcagcttac agaagaaacg gagccgctga tcgaggcggc atcgaccatc tatgaattta 3522061 tcgcggacgg cgattttatg cctgactatg acgcatggac aaacggtgtt tttcgctgga 3522121 aggaccgcga taatatactg gaaggcttta ctgcggaatg gttttccgct gccgtacagg 3522181 attacatcca gtacgacgat gacctgcggg agaaatggga acatatcaag gaaaaatcgc 3522241 ctgcggttac gacattccgt ggccattttc ttgatgaaga ggattttctg gaaggcattg 3522301 gctggattga cgatcaatct ccatttactg tcggcttgcg cttaaatgaa ccggactttg 3522361 acggagacga atggaagatc gagatgtttt tacgcgataa aaagagcggt gctgtagaat 3522421 tctttgacgg actgaagagc ctcaaaaaat cgtggcaggc gtacagcgat aaaatcgcgc 3522481 gtgagcagga ccgctttcac agaacggttc cgtggctgtc gtttgattcc gggacaacgc 3522541 tgatctcgga ggaagaagcc tggatcttcc tgtcagaagc aagtgagacg cttgtcgata 3522601 tgggggtaga aatcctcctg ccgtcctggt ggcagattgt cagagacagc aacatgatgc 3522661 tgaaagcaaa ggtgtcttcc tccccgcgcg gcgagtcatt tgtcggcatg aatgcactgc 3522721 ttgatttcaa ctggcggttt gcgacaaatg gaattgaact gactgaggct gaatttaatg 3522781 agcttgtcgc cagcaacagg cgccttgtta atatccgcgg gcaatgggtt aaaatcgatc 3522841 cgcagtttat caaacagatg aaacgcctga tggaaaaagc agaatcagag ggactccaca 3522901 tgtctgatat tctggcgcgg gagctaatgg atcagcagga tggcggactt gaggattcgg 3522961 acctgattga tacatctgct tttgccggca ttcagtttga tctgtctaaa cagctcaggt 3523021 cactgattcg aaagctcact gccgcggaaa acctgccgga gcacaaagtc agtccttctt 3523081 tcaaaggaac gctccgccct tatcagaaat acggcatgaa ctggctgctg tttctgcggg 3523141 aaagcggttt tggcgcctgt ctggctgacg atatggggct tgggaaaacg attcaaatga 3523201 tcgcctattt ccttcacgtg aaggaaagcg gccgacaaaa aacgcctcat ttgattattg 3523261 cgccgacatc cgtacttggc aactggcagc gggagcttca aacctttgcc cctgatctgt 3523321 ctgtcgcgct ccattatggg ccgcgccggc caaagggtga tgatttcgcc gcgcattatg 3523381 aaaacgcaga cgtggtgctc acttcatacg gtctgtcaca tgccgatact gaagagcttt 3523441 cttctgtgac atggaacacg atctgccttg atgaagcgca aaatattaaa aacgcgcata 3523501 cgaagcaatc acgcgcaatc aggaagctga aggggcttca ccatatcgcg ctgagcggca 3523561 cgccgatgga aaaccgactg actgagctgt ggtctatttt tgacttcatg aataaaggct 3523621 acctcggcag tttgaccggc ttccataaac gctatgtgct gccgatcgaa aaagaccggg 3523681 acgaaaagag aatcggacag cttcagcaat taatccggcc attccttctc cgccggacga 3523741 aacgggatga agaggtcgcg cttaatcttc ctgagaagct ggaagaaaaa gaatttatcc 3523801 ctctgtcagc cgagcaggca tccctttatg agcagctcgt caaagacact tttgaccata 3523861 tgacatccct gaccggcatg cagcgaaaag cgctgatcct cagcatgctt ggacggctca 3523921 agcaaatatg cgatcatccc gcgctttatt taaaggaaga gcaaaccgag ctgctggccg 3523981 gcagatcagt caagctcgaa aaattgctgg aactgatgac agcgatccgc gcccaaaacg 3524041 aaagctgcct gattttcacg caatacattc agatggggaa catgatgaag cggctgcttg 3524101 aaaaaacgtt cggggaacct gtgcaatttt taaatgggag tctctccaag caagagcggg 3524161 atacactcgt tgagaaattt caaaggaaag aatatccgac actgattctt tcactcaaag 3524221 ctggaggcac cggacttaat ttgaccgccg ccaatcacgt catccattat gacagatggt 3524281 ggaacccggc ggttgaaaat caagcgactg accgtgcata ccgcataggc caggagcgct 3524341 ttgtccacgt tcataaaatg attacgacag gaacaatcga agaaaaaatt gatgtcatgc 3524401 ttgaatccaa gcaaaccctg aacgatcaaa ttatccaaag tgaaaactgg attaccgagc 3524461 tttccacaca ggagctcgaa gaattgttta cattaagcgc tacagcgcaa taatcatgac 3524521 taaaaaagct ggctctaaaa gagccagctt ttttccgttc atagccgtca cgccgaattt 3524581 ccaaaaaatc cgttacgccg gttatcaaca gggtgcgctt ttgtggcagc acatatactt 3524641 acaacaaatg tttcatcata tgtgcgacac cgtgttcgtc attggttaag gtgacagcat 3524701 cggctatcga tttgatgtct tcccgggcat tgcccatcgc tacacctttt cccgcagcct 3524761 ccagcatcga tttgtcattt aaactgtcac ctacagcagc agtttcctcg agcggaatat 3524821 tcagctgttt tgcaagcctc ttcagcgcct gccccttgga agctttgcgg gaagaaagct 3524881 caaagttgtg ctcagccgaa ctgacaagcg tcaaatcttc ggcatgctca tatcttttcc 3524941 agcctgcctc aagcttttct ttgaagaaag aaaagccgag aatattgtaa aaatcgattg 3525001 gctcatcggc ttcaaacagc tcttgaaagg agttaatgta agcaaagccc gattggctgt 3525061 attgcacctc ggccgcctgc ttaaggacag aaagatccgc ttccggattt gcgcttctga 3525121 atctgtcgag ctcaacatca agaagttctc tgccgttttg cggcgtataa atcgctgaac 3525181 ctgtgaatac ctcataataa tagttttccg actcaagcca tgagagaatg tcatacgccc 3525241 gtttcttatc aatcgtttcg tgatgataaa gcctgccctc gggatcgtga atgacggcgc 3525301 cgtttgcact gatgacccat gttttgatcc ccagcggttc aaagattgac atgacgtcaa 3525361 aatgagcgcg cccagttgac accaccactt caatgccgtc ccgctgcgcc tgccgcagtg 3525421 cgttttcatt ttccaagctt acctgatgct tgctgttgag taaggttcca tctaagtcaa 3525481 tcgcaattaa tttcacgttt gtcagtcctt tccttcatcc tgctctgtca cgagaagctc 3525541 aacgccgttt cggtcaagca agtcacaaaa tgcctgattc ggcagcctgt ctgtaatcaa 3525601 gaggtcgatt tcattcagct ccgcatactg ataaaaactg gtgctgccca gcttagaatg 3525661 gtctgcaagc gcaattacct gctttgcctg ctgtatcatt ttccgcttca ccatgccatc 3525721 ctcttcatgc gcaattgtaa tgccatgttc ggaaatgccg accacaccaa tcagcgcttt 3525781 atcaacatgg tagcttgaga gcttttcaat cacagaggac ccgtacagaa agcggtgctc 3525841 cttttccagc ttgcctccca gcagataaat ttcaattccc tctttatcgg acagcacatc 3525901 cgcaagatta atcgaattgg tgattacggt acaatcaacc gcattcaaat gctttgcaca 3525961 tgcctgaaca gttgtagagg cgtctaaaat cacccggtct ccatcatgaa taagcgatgc 3526021 tgcaagcctg ccgatcttat ttttttcctc agacactgtt ttcaggcggc cggaatagct 3526081 ttgaattttc tgatgcacag tcggtaaaat ggcgccgcct cttgtgcgga tgatggcatt 3526141 ctgttcctca agtttcacaa gatctcgtcg cgctgtatcc cttgacactt gcaggagcgt 3526201 acagatctgc tccgttgtaa ttcggttatg ctgttttaaa aaatccaaaa tcgctactaa 3526261 tctttcttct tggtacacgc cctcattcct tttctcagca atcatttata agtaattata 3526321 agtttttatt tgattttatt caacattaat aagtgatttt aagtaaaaat gcgtcgagag 3526381 aaccaatttt tcctaagtag gcaaaaagaa agaaccagtc tggtcgactg gtcaattttg 3526441 aggggatgat gcgaagatcc ggataatagt gaatggatag ataacgggag gagcaggggt 3526501 gtcaatcagc agctttttcc cggggtttag ggtccataaa acgaacagtg tcagccaaca 3526561 cttctgttac atacacgtta acgccttcct cgttttcata gcttcttgtc tgaatccgtc 3526621 cgcttacgcc gacgagagaa cctttttggc aatacaacgc cgtgttttca gctgtttttc 3526681 tccaaagtgt gcaattgacg taatcagctt cgatttcacc tgaagcattc ttgaagctgc 3526741 ggttcaccgc gagcgtaaca tgtgcaactg ccgcaccggc ggaagtgtag cgaagatcag 3526801 gatcttttgt aagacgtccg acaagcatga cctgattgaa catgcgattc ctcctctcct 3526861 tgcggttgta tgtattgtaa atgatgcaac aagaaaagaa aaacgcttaa aaatggcttt 3526921 cagcctctgt ttttatcttt cgttttcatt tttccttcag ctaaaaacat cttttgcttt 3526981 tttcctttga agaaatatgt actttttaaa aaacggaaaa agatttgctt tgtcagccag 3527041 ttttgcgtat tcatgcgcac ataggaagag ccatcccacg caaaccactg aaagctcaat 3527101 tttttttccg gcattgacag cttgatttta tactgctcca tgccatcttg tgtttcgtat 3527161 aaaaaactta ttcttccttt tttgttcaga tgaacctcaa acacttcttt acggcttaac 3527221 atatatgtta cttccttttg aatcaaatga ctttcagaag gaacgccgtc aatataaatt 3527281 tcttttaaac gaaattgatt cataccacat ctctccgtaa tccatagtca gttacagtat 3527341 aatgaaaaaa tagaaattat taaatgtttc gctcatacaa aattctttag ccccaacatt 3527401 gcaggatttt ttcctcgaaa acgtttatgt tataatggaa ggcaagaaaa ctttggaagt 3527461 aatcggggtg agaagaaatg aaaaccttta aactggttga cctgaatgtg gaacgagtgg 3527521 acaaggaaga acaatcaatt gaacagtttc cccttattga cggactgatt ataaataaag 3527581 aagacggtga aaatcactgg ctgattgagg cgcttgtaca gaaagaacat ctgtcttttt 3527641 ttgaacagct tcaaaacagc caatctgaag ccaaagtatt tgtaacgatc acgaaaaaaa 3527701 gcaatcgccc cgcccagctg acagcagcag tgaaaaatat cgtcaagctg gaagaaagca 3527761 ttcaggtttt actctacgga caaatggtca caagaaaaca gcagggcact gaaaccattc 3527821 tcgagtccct tgtaaaagag ggctatacag gaacaaaact cattgaggca tttaagcaaa 3527881 aattataaat atgagggggc atgttcccca aaacagactc agaaccgaag agcatcacaa 3527941 tagacattta gaatagatat gttctgcatg aaaaaagctg ccgttttgaa cggcagcttt 3528001 tctcttcgtg ctttcactct tgcatattta atttgtatgg ccaaaagaat caaccaattc 3528061 ccctttcaca acgaggcgcc cttcggtttt gaccgccttg tcacatgtga ttaacgtaat 3528121 ctcctttttg tttgtctcct caactacatc tgcatccatt tccgatatga tgtctttcga 3528181 tgttacagaa tagatataat cctttttaaa atccgtgatg acaatttggg cacctgtttt 3528241 tatgttttcc agaggtccga acagaagatt cttttgcttc aaatgatggc ccgccaacgg 3528301 ataatttccc tcacccattt tttgatcccg gcgcattgtt gccgccccta tcaaaagatt 3528361 ttcattggtt gtgcctttta cgatcggaag ctccagatcg acacttttaa ttgttatccg 3528421 ccgccttgat tgtgaagtaa aaataagtat atttcacgtg ctttcgacgt tctccacttg 3528481 actggaatgc tttaatggcg atcccggcat ctgtagcttc aggctttcct tcagaggaat 3528541 cagaaatctc aaactctatt ttctcagtgt tcagcacata accggctggc gctttcgttt 3528601 caacaaaagc gtattgtccc ggtgcaaggc ctgaagctgt gacttgatga tgccggatat 3528661 gactggtttc gaagtctgta tgaaaattcg cgaacgattc agcatggttg atcttccggt 3528721 tctgatcatt acagctgcca ttatcggcca tgacaaatac aaggcttttc atgccggagc 3528781 gaatgacatt ttgcaaaaac cctatcatta ctctgaattt atggcgcgta ttcaaaacct 3528841 gataatgatg aaacatacag caaatcaagc cacaagaatg gaaatggcgt ttctccagtc 3528901 gcaaatcaag cctcattttc tttataatgt attaaacacg attatttctc tcactcattt 3528961 ggatattgaa aaggcccggg aggtaacaga ggaatttacc aactatttaa gaatgagttt 3529021 tgactttcaa aatacatcag ccatcagttc cttcagacat gagctttcga ttatcaattc 3529081 ctatctttct atagaaaaga cgcgattcag taatcggctt gaggttcttt tcgatataga 3529141 tgaagacatt gactttatcc ttccgccttt aatgattcag cccttggtgg aaaatgccgt 3529201 tcttcacggt gtcagcaaga aaagaggcgg aggatggatc aaactgacag ctaaaaaaca 3529261 aagcaaaaat gagtatcaca tcaaagtaga ggataacggt cccgggataa ctccggaaaa 3529321 acaaatagat ctcttatcaa cggattttga tcgcagcgtc ggattgaaaa atatcaatca 3529381 gcggctgaaa catttttgcg gaagcgagtt gatgatcagc agcactccgg atgcaggcac 3529441 ctctgtctca atgctcattc atctcgctga aacaacagga agccctaaag aactgaagga 3529501 cacagaacga acctaaacga aaattgagat aaaaaaagac gccgtttcta acggcatctt 3529561 ttttattccg gcgactttgc ttgctgcttc agcaggtctc tgatttcttt cagcagctcc 3529621 tcctgcgcat ccaccgcttc ctccgcagcc tcttcttctg cttctttttt gcgccttaac 3529681 ccattcaaag tccgaatgac gataaaaatg gagaacgata taattaagaa gttcacaatc 3529741 gtctgtataa agctgccata tttcactaca gcatcgccaa acgtaaacga caggcctgaa 3529801 aagtcaagcc ctcccagcag caaaccgacc aaaggcataa tgatatcatt tactagagat 3529861 gtgacgatct ttccgaaagc gccgcctatc acaacaccaa tcgcaaggtc tacgatattc 3529921 ccccgcatgg caaaggcttt aaattcattc cacatacaat cacctgcttt tctatatttg 3529981 taaagaaaaa aagacaaatg tgccgctggc catctgcctt ttttcaatta ttctccgagg 3530041 gcaaaagtca gttctacttc gcaaacgact tcgccatcaa ctgtggcaac gccttttccg 3530101 cgcccgattg tgccgcgggc acgaatgatt tcaacctcaa ggtgaagctg gtcaccaggc 3530161 ttgacttgtt ttttaaagcg gcagttatca atgcctgcaa aaaaagccag tctgccgcgg 3530221 ttttcttctt taatcaacat cgcaacagct ccgacttgag cgagtgcttc tacgattaat 3530281 acgccgggca taaccgggta ctgaggaaaa tgtccgttaa agaactcttc attagcggtt 3530341 acatttttat agccttttgc ccgtttgccc tcttcaactt ccgtaatccg atccacaagc 3530401 aaaaacggat aacggtgagg aataatttct ttaatttgct gagtatcaag cattgtcttg 3530461 acatctcctt catctgcatt agtatgtata gcaatcatca aagatccaat ctgtacattt 3530521 gaaaagtata ttatgaatta atctcttttt caaccgcgct aaaatgtaac caactgtcaa 3530581 tgagagccgt caaaagttat gatatgataa ttatagattt taccaatagc aaagaggtag 3530641 gaaaatgatt tcgaagttta ttgaaaaaag aatgctaaac atgttagacg agtggtattc 3530701 cgcaatgagc aaacgcaaaa tgaatcacgt ttgcacactg aaagagaaaa ttgatcagca 3530761 ccttccaaag atcaaaaaga acacaaaact ttggatgcgt tatcaattgt ttcaggcccg 3530821 ccatcagctg ctttttgaaa accagaacgg actcgattca ttgttcgatg gcctatatgg 3530881 cctggaagac aaaatggatg atgaattgaa atattatctg tattttttct ctgggttata 3530941 tgagatggta aaaacagctc cgaaacatgc agtacatcat tttaaaaaag ctgaacagta 3531001 cctggccgcc attcacaata cgtttgaagc cgctgattta tattatcaaa ccgccggcgc 3531061 ctattacttg atgaaatcac cgccgctttc cgtccaatac gtcaaaaaag cattacacat 3531121 ctatttgcac caattcggct atatcaaaaa ggtaatcacc tgtaaacttt tgctcgccgt 3531181 gaattatatt gatcaagaac gctatgaaaa agctgaacag cttttcaaag aaatcattaa 3531241 gaaaacccag caactacatg acgaaaacct gctatgccac gcttattata accttggctt 3531301 tttaaaagcg accgagaaaa aagaccagga agcgcttctt tactttagaa aagtattaaa 3531361 gaatcaagaa tttgaaatga attcaccagt ctcatatctt cattgtgtgt acgagtctgt 3531421 cagagcgctt tttaaaacag ggaacatcac agaagctaaa gccgtccttc aaaaaggaaa 3531481 agaattatct gaaaaggtag acattcaaac catttattta aaattaaaaa cgcttgaagc 3531541 cctctacaca tcagccgaag acccttatga gcagctgctc gaatatgtgc ttgaattaga 3531601 aaaaatcgag gcgtgggtgg atttagaagt gctgttagaa gatattacgg aatactacaa 3531661 aaaaaaggac gatttcgaaa aagccgcttt ttttatcatg cgcggctgat tgaaaaacgc 3531721 ccattttctt attatctgac tgaattgatt aaaccgagca tttgatctcc cattgtgatc 3531781 gttctgctgt tcagctgata tgaacgctgg gacgtgatca aatctgtcat ttgttctgaa 3531841 atatcgacat tggacatctc aagtgagccc tgctgcatgc cgatgttttg tctattagcg 3531901 ccgttcagct cttcaaaagc tgccgcatta tcaatagaga aaaggttatt cccttcggat 3531961 ttcagctctt gagggttatt cacttggaca acgccaagat taaaccgctg aaccgcgttt 3532021 ccgtcagatg cggttaaggt gccgttctta ttaatggtga tattcttcat tgagctgtcg 3532081 atgttcactg tattgccgtt ctcatcaagt acgggatacc catttccagt gacgagctgc 3532141 agctggttgg cattcgcagc ggacggcgtt acatacagcg ccccgtccct cgtatactgg 3532201 cggtttccat ttacatttac ctgaagatac tggtatggag acgtaaatgc gatatccaga 3532261 tcgcgatcgg tcttctgaat gcttccttga tcagagacta ggcgtgaact catcatcgct 3532321 ccgacgccaa ggcgcaagcc gggcggcgtt tttcgggctt ttgccacttc ctcgtttttt 3532381 tcatcaacct gatcgaattg ctgtctgaca agctcagaaa aattcgtatc ttttgcctta 3532441 tagccggttg tgttgctgtt tgaaaggttg ctgctgattg tgtcaatctg ctgctgcagc 3532501 tggtttaagg ttgttgatgc cgttagcatt gacctgagca tagttgatgt cccccgtttt 3532561 tttcttccgt tttcttaaat ttttccaatt tcatttgctg ctttatccat acttttatcg 3532621 taagcctgaa taaccttctg attcgcctca aacgatctgt acgcttcagt catttctgta 3532681 taggcgcttg tcacatccac gtttgaaagc tctgagacgc cttgttttaa tgaataggct 3532741 acctgattat ttccggctgc gcttggcaga tcattaccgt ccgccgtgct gtacaaatca 3532801 tttccgtccc gtttgagatt gcggacatct tccgccattc tgacatcaat ctggccggct 3532861 gtgcgtccgt tcgttgtcac agtaccgttt tcagacacag tgaaattctc attatcaaca 3532921 gtgattggct ggcgatccgt cgataaaata gggcgtccgt tgatcgtcag ctgattgttc 3532981 tcatttagtg aaaatgtgct gctttttgaa taacggattc catccgctgt ttgaaccgga 3533041 taaaaaagag cagctttttc attggtttcc gcactcatcg gaacttgatt ttcgatcaat 3533101 gcaatgtctg taggctggtc tgtggacttc aggcttccct gtgtaaagag aggcttgagc 3533161 tcctgcatat atactccggt attcacggaa ccgatttccg tccttgatgt cccggccgga 3533221 gattttgatt ctattctgct gagcagcatc tcagggaacg cgcgcataga gccttgatca 3533281 gctttatatc ctgatgtatt tgcgttagca atattatttg aaagcatttc cgttcttcgc 3533341 tgctgggcaa tcattgcgga tgttgctgta tataatcctt ttaacaaatt tcccacctct 3533401 aaaaatggca ttttttccag ttgtcatata ggaacgttcg ttctataata aaaactcagt 3533461 attttatcct attatcgtca tttaacatct tttcgtgaag gctttttcat aaaaaaacct 3533521 cattcttttt cagaatgagg tttgtgaaat cagcttagtt tgcgtttagg aagcttgtcc 3533581 atattatcaa gcatgacacc tgtgccgatg gctacgcaat ccataggatt ttcagcaacg 3533641 aggaccggta ccttcagctc ttcagcaagc agctggtcaa ggccgtttaa gagcgcgcct 3533701 ccgccggtaa taataacgcc gcggtcaata atatcagcag aaagttcagg cggtgttctt 3533761 tcgagcactt gttttgcagc ctgaacaata acagcgacag attcacgaag ggcttcttca 3533821 acttctttac tgtttactgt aattgttctt ggaagaccgg aaaccatgtc ccgtccgcga 3533881 atggaaattt cctcgtgacg tgcgtctggg aaaacagttg cgactttaat cttaatatcc 3533941 tccgcagtac gttcgccgat cagcagcttg tactcgcgtt tgatataatt taagatttcc 3534001 atgtcaaact tgtccccagc cattttaata gaagaggagg tgacaatatc gcccattgaa 3534061 ataaccgcga tatccgtcgt cccgcctccg atgtctacaa ccatgttacc gcttggctgg 3534121 aatatttcca tacccgcgcc gatagcggca actttaggtt cttcttcaag gtacacatgt 3534181 ttcccgccgc ttttttctgc agcttcttta attgcttttt gctcaacgga tgtaatattc 3534241 gtcgggcagc aaatgagcat gcgcggcttt gagaacaggc cttttacatt cagcttgtta 3534301 ataaaatgtt tcagcattgc ttctgttact tcaaagtcag caataactcc gtctttcagc 3534361 gggcgaatcg caacaatatt cccaggtgta cgtccaacca ttcgtcttgc ctcttcgcca 3534421 accgccagca ctttgccgct gtttttatca agtgcaacaa cggaaggttc attcagaaca 3534481 attcctttac ctttaacatg gatcagtaca tttgcagtac cgaggtcaat accaatatcc 3534541 cttgcaaaca tctatttata tcctccttga aaatctgttt cacagtaaat atccacattg 3534601 tgccctaatt atatatatta tcataaaata tagaaaaaaa gttggaagca caataagttc 3534661 tttacaaatt tttgcggatg ttttatgaac gatttcaaga aggcaatgcc aggtgattac 3534721 gattgctgaa caggctctcc ttcgagaatt tcatcttttt tatatttgag ctttgtcgct 3534781 tctcctcctc ttaaatgcct gatggattta tgataatcga gtatttcttt cacttcgttt 3534841 gccaagtcgg ggttaatttc aggcagacgc tctgttaaat ccttgtgtac tgtacttttg 3534901 gaaacaccaa attccttcgc aatgacacga acggttttct ttgtctccac gatgtacttc 3534961 cctatcttga ttgttcgctc tttgatgtaa tcgtgcacac cactcgacct ccctaaaatg 3535021 gatgtgagaa gtgtgaaatg agatccgtat tctgtaaaga gtcgttcatt atgccgcttc 3535081 ttcgttgtat ggttttaaaa gtaagtttgt gaaatatgcc cacgatccct cacctcaaac 3535141 actctctttg ttaggtttgt aacagtgtat tagcattctt ttgggaatat gctaaaaact 3535201 caataaggac aaggggtgaa acgaactttt tcagattcag caaactattt cgcgtcacta 3535261 aattttcatc tttacaacta ttgatcgctc ctgtaaaatg aaataagcaa ttagttactt 3535321 aggtaagttt tttagaagga gaccgacatg tcctacgtca acagacacct cattcatcaa 3535381 atcaaccaaa gcgcccgcct gattgccaag aaagccaatg aacagctaga gccattcggc 3535441 ctttattcat ctcaatggtc agttttatat tgtttgcgta cgatcggacc aatgactcaa 3535501 aaagagattt ggtcctattt aaatgtggaa gcgccgactg tgactcggac gatcaaacgc 3535561 ctggaggaga acggctgggt tcagagacgg caaggtgaag acaaacggga aaaacttgtt 3535621 gtcctcacaa aagaagccga gaaaaaatac gaagaaatca atgtgaaaat gttgaaattc 3535681 gaggaagagc tgcttgcaga tttccgggat gaagataaag aagctttttc tcatttattc 3535741 cgcatgtttt tacaacaatg aaaataagga agtgacatac atttgaaaaa agcggatgcg 3535801 atatggacca aggattttat tatggtcctg cttgtcaatt tatttgtgtt tgtgttcttt 3535861 tatacatttt taactgtatt gccgatctat acactgcaag agcttggcgg cacagaatca 3535921 caaggcgggc ttttaatcag cctgttcctt ctgtctgcga tcattacacg gcctttctcc 3535981 ggagccatcg ttgagcgttt cgggaagaaa agaatggcga ttgtatcaat ggcgctcttc 3536041 gccctatcat cttttctgta tatgccgatt cataactttt ccctgctgct cggattgcgg 3536101 ttcttccaag ggatttggtt cagcatttta acgactgtta caggtgcaat tgccgctgat 3536161 attattccag ccaaacggcg cggtgaaggg cttggatact ttgccatgtc tatgaacctc 3536221 gctatggcga tcgggccttt ccttggcctg aatttgatga gagtggtaag ctttcctgta 3536281 ttctttacag cctttgcgct gtttatggtt gcgggcttac ttgtttcgtt cttgataaaa 3536341 gtgccgcaaa gtaaggacag cggcacgact gtattccgtt ttgcgttctc ggatatgttt 3536401 gaaaagggcg cactcaaaat tgcgacggtc ggtttgttta tttctttctg ttattcaaca 3536461 gtcacatcat atctgtctgt attcgccaaa tcagttgacc tttcggatat cagcggatat 3536521 ttctttgttt gttttgcggt gacaatgatg attgcacgcc cgttcacagg gaaattgttc 3536581 gacaaagtcg gaccgggcat tgtcatttat ccatcaatcc tgattttctc tgtcggactc 3536641 tgcatgctgt ccttcacaca tagcggctta atgcttctgc tttcaggggc ggttatcggt 3536701 cttggctacg gatcaatcgt tccttgcatg caaacattgg cgattcagaa atctccggct 3536761 caccgctccg gttttgcgac ggcaacgttc tttaccttct ttgacagcgg aattgctgta 3536821 ggatcgtatg tattcggatt gtttgtagca tctgccggct tctctgccat ttatttaaca 3536881 gcggggctgt tcgttttaat tgctctgctt ctctacacgt ggagccagaa aaaacctgca 3536941 gaggctgaag gaaaagtgtc tattgcagaa taacttgtca gactgccggg aaatcccggc 3537001 agtctttttt ccattaaaac acggcgccct ctcggttgaa cgagagaacg ccgcttatag 3537061 caattattca atgacaggcc gcgcaggtga atcaggatct aacgaaaaat cataggacgc 3537121 ttcatcacga aacatcggat cggcatatat ggattgttga tcgttttttg ttgcttttcg 3537181 atacgaagaa aatgaatcat attctttctt tttccacatc catatgccgt cttgatccgc 3537241 ttccttgtgg tacacgttat gattgaccgt attaccttcg ttttctgtaa agtcgtttcc 3537301 gataaataat ctggaatcac cggccgtcaa tatattcttt tcaattgtgt tgtttttcgt 3537361 atcgtactgc agcagcagct gtccgccgta cagtcccttt gtgtcattcc ggtacataat 3537421 attgcgggca atcagagaat tgctggtgcc gccccgcttt ttgtcatatc ctccgattga 3537481 aataccggtg tacgcattgt tgtacacttt gttgtctgtg atctgaatgg catttgcata 3537541 ctttcctttg tgttcagacg ttgcttcaat cccaatatcg ttatcgtaaa ctgtgttgtt 3537601 cttaatttcg atatcgtgtc ctccatcgac ataaatcccg cccgctgagt attcatctcc 3537661 ataagcagga ttgccgtaag tcgagttttg ataaactgta ttgttttcta cgactccgtt 3537721 tcgcacgtaa tcgtttttat ccgcggttcc ctcataacca attagatcaa tcccgatgtt 3537781 attattgttg cggaccacat tgcctgcaac tgtgaagccg tcgatattac cgttcagcac 3537841 aactgcttca ctcgctccaa gcgtcagttt ctcaactgta ttgtcctcga ttcggatgtc 3537901 tttcatgctg ccagtcccat aaactgcgat tccgtgagca tttccttcat ccgctgttgt 3537961 cttaatcccc cggatgtgat tatccttaat ggcgatatga ctgctggacc ctgatacata 3538021 aatccctata gcagttgctt cctcagatga aacagaaaga tcttgaattg ttaaaccgct 3538081 gatggcaatg tcatgtttat cgtgaatacg aataagcggt gtttcatatt cagcgttcgc 3538141 aacggattca ccgctaatca cgacgttttc attttcatag tttcggaatg tgataggctt 3538201 tccgtccgta ccgctgtgct ttacatcaag ggtctcatga tacgtgccct cccgaatcat 3538261 gacagttgtg ccggcagcag ccttctcaga tgcgtgtgcc aatgtacgaa acggcttttc 3538321 ttttgttcct tcattttgat cactgccatt tggcgaaaca tacagataat ccccagatcc 3538381 ttcctcattc gcttttgtct tatcataaac gaaagcgagg atgacagacg ttaaaacacc 3538441 cgccaaaaga ataaaatacc attttctcat tttcgattcc catttcgttt tagaatagat 3538501 ttctaaaacc attataaatg ttctatttat ggaaaaccat ttcaaaaata tgaaaatata 3538561 ccgtctaaat agatcttatt cagcctggcg gacctgcgca tgttcaactg tttcaattgc 3538621 caatgatgca ggcgggtgaa cacgcatcag aacaatgtag aaaagaaagg aaatcagcac 3538681 acctacaaac caagaaatat cgtataagct cttcaataca ggaacataca tgccaatcag 3538741 cgaaatcagc gctcctaaca ttgtggctgc aaacgcacgg taattgtagc ccttccaata 3538801 cacataccgt cctgtttcgg aatacaggtc atctaccgag agctcacgtt tgcgaatgat 3538861 aaaatagtcg gccatcatca cgcctgccac cggtccaagc atgccgccta ttaagccaag 3538921 aaacgcatac acgcttgtcg cgctctccat cagcttccac ggaaccgtaa ataaagcgag 3538981 caacgctgtg ataaagctgc cacgtttgaa attgatatat ttcggcaggg cattcgctat 3539041 atcataagcg ggtgatacga tattcgccgc gacatttaca gagatcgtgg cgatgcagag 3539101 tgtgatcacg gacaagacga tgacataagg gttatcaaac cgcgccaaaa tatcgacaac 3539161 atcccaaatc ggctctccga acgcgacctg cgagccggag gtcaccgtaa tacttgcgaa 3539221 tgcgaacagc gcaaacgttc ccggcaaacc gtaaaattgt cctttgattt gctctttttg 3539281 tgtttcagca aaccgtgtaa aatcaggtat atttaagatc aatgtcgccc agatgccgat 3539341 gatgccagta actccggcag caaacggcca gaatgtttct gaaaacgtat gaaactttcc 3539401 tggttgagag tatatcgggc ccaatcctcc agcaatatca acggcccacc ataccatgcc 3539461 gccaaatacc agatacacta aaggccctgc ccacacctca aaacgtttaa tcgactccat 3539521 gccgtgatgc aatacgagta aatgaatggc ccaaaagaat acaaaggaaa gcaaaccgga 3539581 caagtgaatg ccgagaatgt tccactcgcc gccaatttct ccccaacctg gccacatatt 3539641 caaaagcaaa atgttcagtg ccgtgctacc cgcaaaggtc tggatgccaa gccacatgat 3539701 agctgtaaac gcccttagaa gcgcggggat attcgcgccg tatatcccgt aagaagcccg 3539761 aatgatcact ggaaacggca gcccgtattt tgtccccgca tggccgttta aggcaagagc 3539821 gccaaatagg ataagtgatg ccgtaataat gatcgccagc acctgccaag gcgaaaggcc 3539881 gatcgcaatt aatcctccca cggtcgcgta ggtcggtatg ttatgtatac atcccatcca 3539941 aatggaggca aagttcattg ctttccacgt ccgtttttcc tgtcccaaag gcaccagatc 3540001 ttcattgctc agcctgttgg attgctgctg actctctttt aatttcatag ccggctcccc 3540061 tttccatatt gtctatatgt cgtcacacgt tatgtttttt gacattagat gtcacttaat 3540121 ataactgaag agtcagacaa taacactggc tatgatatac aattttcccg tttgtatttg 3540181 aacagcttaa acaagaaaaa gagacagacc tcagagcccg tctctttctt aagatgcagt 3540241 tttcattaat gcagcaaatc tcacagccat taacaggctt gctccgcccg ctataatcat 3540301 aatgattccc atcatatcaa aatgggctgc cgtgatttct ttaccaaaaa gaatgccaag 3540361 gatcaccgaa gacaaaatcg atcctaggta acggcaggtt tgaaacaggc ctgaagtcgt 3540421 tcctaccatg ttggaaggac tcgtttccag catcgctgcc tgaagcgcga cattgcccag 3540481 tccgtagcct atacccaaga gcgacagaat gaggccttta ccgatggtct ggacattgat 3540541 aaaaaagatg gttaagagca cggctccagc cgtcatcaaa agcgctcccg caaagatcgg 3540601 cttgacgaca ccagatcggt cgatccattt gccggttaga ggtgacacaa cgatgctcat 3540661 tccagacata aacagcataa acaggccgct cgtttgaaca gaaagatgca tttcatcctg 3540721 aaagtaactt ggcaaaccaa aaaataaaca atagaagaaa acattcaata aaataaactg 3540781 aacatacacg gctgacaggt ttcgctgtgt tttaaacaga cggacatcaa taaacggctt 3540841 atccgttttc agctcgcgcc agacaaacgc acagagcaga agcaagccaa gcacaccttc 3540901 aaccgcatgc ggcgacgtgc tgaacgacag caaaaaggat agaaggaaaa tgattccccc 3540961 ggcaaataaa acaattccaa gaatatcgag ctgccgaata atggttttga ttcctgcccc 3541021 ttttttctga tctttcggga acatatacag gcccaataag aagctgagga taataaacgg 3541081 caaattaacg ataaagatcg ccggccagcc tccccataca atcaaaaacc cgccggctgt 3541141 cggccccagc gccgtcatgg cggacgcaaa aatagagagt acagccaagg ctgaagcttg 3541201 gcgctcatga atatgattcc gaatcaagcc gacacctgac ggataaatcg cactgctccc 3541261 caccgattga aacagccgca tgaccaataa tgtcataaac gtcggcgcaa acggcgcccc 3541321 gatggcagaa accgcaacaa gaataagccc gaataaaaac aagcgtttcc gcccaatcaa 3541381 atcaccgagc tttcccgtta cgggctgcgc tacggcactc gccaagtaaa acgaggaaat 3541441 cagccaggaa accgttgtaa acgagaggtg aaactcatgc tggatgctat ggagcgcaag 3541501 agagatcata gacgagttca gcggattcag cattgttccc gaagccacag ctgttaaaaa 3541561 aacagctcgg ctttttttcg ataacatcat ttcacttgtt ccagaaactc ttccgttgtc 3541621 cgcgatttac cgattctcgg gaaaataaag cgcagtgtgg cttcatgctc ttcatcgcta 3541681 aatgtggaca tggcatctgt aataaaaatc tgctgatagc caagctgaaa tgcctcccgt 3541741 gctgtgcttt ccaccccgat attcgttgcg atgccgcaca atacaatcgt atcaatgccg 3541801 cgacgtctca gctgcaagtc taaatctgtg ccaaaaaaag caccccattg ccgttttgtc 3541861 acagtataat cgccatcctg cacaccgatt tccggaacaa attcggccca gtccgccggc 3541921 atttcccctg aacctccctg cgcaggctca tccgtttgcg gcttcagggc gtccgctcca 3541981 tcatgaaagg ctacatttac aaagctgatg aacccgttat gtttccgaaa ttcatctacg 3542041 agctttttcg cgttcgggac aacctggccg ctttgatcaa tcggcacaat tcccttttgt 3542101 aaatcaatga taaccaatgc tgttttttga aaatcaatgt tgagtgtatt catcatacgt 3542161 ctcctcctga tactgttagt gtttctcaca ttgcatattt tactcttcac actgcctaag 3542221 ttcttttatg atgcttgtga aattctcaga aggagcgttt tctcatgatt tttcttttat 3542281 gtagtagtaa caggttgtgc atacgaacaa accggcaagc actgtaatca taaagggcgt 3542341 catcgcttca tcacctgcct gctgtctatc ggttcctgcc tgaaaatgcc catgaatttg 3542401 cggcggtcca tccaaagcag gataagacac ataaccatta atatcgtgct aagatcctgc 3542461 acgccaatat caaaacaata gttaatcaag acgatgttca caataatggg cataaaaata 3542521 accgccccta atgcagccgt tcgcggaatc agtaataaaa cagctgccag gatttcacca 3542581 aaacctataa acagttcata gacatgagaa taaccgaaaa atgtccacgc gatcgtaaac 3542641 cccttcccgg cagccgcctc gatttcaggc gtcacctcgc caaactggcc aattaccact 3542701 ttcgccagac cgtacacgaa aaaattaaag gctaaaaaca atcggaacgt cgcgggaatc 3542761 gacttgcgta ccgctttcct cagcctgccg cctttattca tcatacatcc ccctcagtgt 3542821 attatttgat gtagtacact taatacagta tagagtattc taattaatgt caattccctt 3542881 ttcagctcat atgaatagtt tcttttatag atacaaagtc ttatatcgca aaaaatgcca 3542941 ttctccttcc tttccatccc tcgataacat ttctcaaaaa ccatgtcagg aaatcttaca 3543001 tgaaaatgtt ttatcattct tttttctcta taatgaagaa atataataat tgctttttat 3543061 tctgaaagat acggaggaat gagacatgca aatgggcgat acagttttta tgttcttttg 3543121 cgctttactc gtgtggctga tgaccccggg attagcgtta ttttatggag gaatggtaaa 3543181 gagcaaaaat gtgctgagca ctgccatgca cagtttctct tccattgcca tcgtttccat 3543241 cgtttgggtg ctgttcggat atacacttgc cttcgcacca ggcaattcaa tcatcggcgg 3543301 gctggagtgg gcaggcctca aaggggtcgg atttgatccg ggagattaca gcgataccat 3543361 cccccactcg ttatttatga tgttccaaat gacgttcgcc gttctgacta cagcgattat 3543421 ttccggggct ttcgcagagc ggatgcgatt cggcgctttt cttttattct cggttttatg 3543481 ggcctctttg gtttacacac ccgtagcgca ctgggtatgg ggcggcggct ggatcggcca 3543541 gcttggagcg ctcgatttcg ctggcggcaa tgttgttcat atttcctccg gggtggcagg 3543601 acttgttctt gccattgtgc tcggcaaacg gaaagacggt acagcgtctt ctccgcataa 3543661 cctcatttac accttcttag gaggagcttt gatttggttc ggctggttcg gctttaacgt 3543721 cggcagcgca ttgaccttag atggtgtggc catgtacgcg ttcatcaaca caaacaccgc 3543781 ggctgcagcc gggatcgccg gctggatctt agtagaatgg atcattaaca aaaaaccgac 3543841 aatgctcgga gcggtatctg gggcaatcgc cgggcttgtc gccattacgc cggctgccgg 3543901 atttgtcaca ccgttcgctt ccattattat cggcatcatc ggcggagctg tttgtttctg 3543961 gggagtattc tcgcttaaaa agaaattcgg atacgacgac gcgcttgacg cctttggcct 3544021 gcacgggatc ggcggcacat ggggcggaat cgcaacagga ttattcgcaa caacctctgt 3544081 taactcagcg ggcgcagatg ggttatttta cggtgatgca agcttaatct ggaaacaaat 3544141 cgtcgccatc gccgccactt atgtttttgt atttattgtc actttcgtta ttattaaaat 3544201 tgtaagcctc ttccttcccc ttcgcgcaac tgaagaagaa gagtcacttg ggcttgactt 3544261 aacgatgcac ggggaaaaag catatcaaga ttctatgtga ggagtgacgc tatgagcggt 3544321 caaatgttca aggtagaaat tgtaacgcgt ccggcaaatt ttgaaaagct gaagcaggaa 3544381 ctcggaaaaa tcggagtgac ctctctgact ttctccaatg tacacggctg cggccttcaa 3544441 aaagcacata cggagctcta tcgaggggta aaaatagaaa gcaatgtata cgagcgttta 3544501 aaaatagaaa ttgtggtcag caaggttcct gttgatcaag tgacagagac cgctaaaagg 3544561 gtgctgaaaa cgggatcacc aggtgacggt aaaatatttg tctatgaaat cagcaatacg 3544621 atcaacatcc gcacaggcga agaaggacct gaagcacttt aatatcggta cgagattcgg 3544681 acactccgga tctctttttt tgtgcacaga atccccccag aaaccgcgat tcctcttcga 3544741 attctcttca agcgccgtta tttcagacaa tctctatttt tatttgaaac ttttcatgag 3544801 taagattagt ctactaaata taaaaatgta aaaggtgatt atttgaacta cgaaattttt 3544861 aaagcaatcc atggactatc tcatcacaat tcagttctcg attccattat ggtcttcatc 3544921 acggaatatg ccattgtcgc ctatgccctt atcctattgg caatctggct gtttgggaac 3544981 acacaaagca gaaaacatgt gctatacgca ggcatcacag gaattgcagg ccttgtgatc 3545041 aactatttga ttacgcttgt ttatttcgaa ccgcgcccgt tcgttgcgca tacagtgcat 3545101 acactgattc cgcatgctgc ggatgcttca tttccaagtg accatacgac aggtgcatta 3545161 gcgatttcta ttgcgatgct tttcagaaac cgcaaaatcg gctggccgct tgtcattttt 3545221 gggcttttga caggcttttc gagaatttgg gtgggacatc actatccggt agatgtattg 3545281 ggcagcctcg ttgtcgccat cattatcggg ttccttttct ttagattttc agatctgctt 3545341 cgcccgttcg tcgatttggt cgtgaggatc tacgaagcca ttatcaataa actgacgaaa 3545401 aaaccaaccg atcaaaattt ctaagaaaga caaaagccgg cgtctgaaat caagacagcc 3545461 ggctttaata tttctcatac atctcttgtt ttcttcgctt cgccaacaca tataaaccat 3545521 aaaacaaccc aattccaaca gcatcgatga gcacatcccg gatacaacca ttcctgctga 3545581 agaagagctg aagaacttct gtgaaaaaag caaacgcaaa tgagccggct gcagctgatc 3545641 ttatgctgcc ccgctgtttc cacagcaaat atgtcagcac aaagaaggaa aacgcgtgtc 3545701 cgattttttg aataaacgct tcaggtacag taagctcagt aaaatccata actaaaaatt 3545761 gagacagatc agggtgcggc tgaaaatgaa aagccaccgt ttgcgatacg accatgccgc 3545821 tgaagctttc cgtacagaca gaaagcagga taaaaaagat ccagcctgcg agcaataggc 3545881 ggttcatgac ataacctcct ttataacgta cgtgcctaca tgtaactaca tagacggtaa 3545941 aacaaagcaa aaagtaacag aaaaaaacgc ccatcacaag gatagacgtt ttcttcatta 3546001 agactgttca gtgtcttctg ttgtgctgct ttctttagaa ccagatttgt cagttgaatc 3546061 atcctttttc tcaccggatt tttcttctgt tcctttttca gttgatccgt cctttttctc 3546121 ggaagattgc tgaatggatt cttctgtttc ttgggtggca gctttttcaa tagaagaaac 3546181 tggtttgtcc ataaagttta acggattcat tgcaacccca tctttacgga tttcaaagtg 3546241 cacgtggttt ccgctgtctt cactgtaaag gttcttgcca gattttccga tcacttgatt 3546301 ttgttttact ttgtcacctt gctctacgct tacttcggaa agagattgat acacagtcga 3546361 taaaccgtcg gcatgttcta cttccacaac atatcccagc actggatctt tttcagcttt 3546421 aacaaccgta ccgctcagag aagcagagac atcgaaatct tttccgtctt tctcagctaa 3546481 gtcaattcct ttgcttaggc tgtacgtgtt attataggta acgagtgctg cttctttctc 3546541 ttcttttgcg gcatcggttt catagaactt tttcacaaca gaaacgtttt cagaatcaac 3546601 aaccggcatt gcgacatttt ccattgactt tcctacttca actgcatcgt cgttgttgtc 3546661 atatgcggag tttccgccgt tatcagccaa ctgatccttt acctcatcat ttgatactga 3546721 ttgataccaa aggacagctg ttaaaatgac ggccgcactg actaagtaaa ttgcagggaa 3546781 cacccagcgt ttacgaaaaa actgctgaag ttttttgact tgagaagttt tcttttcttc 3546841 ctctctcatt gtttcatcac ctcagcaaca ttctgaacac ttttctgaaa atatatacaa 3546901 cctatccaaa aaaacttttt tagatgtagt ttgcacagac tgaacgaaaa tatgtatttt 3546961 tttgagagga gtgccaaaaa cgtatgaaca tgacattgcg tcttgctgaa catagagact 3547021 tggaggctgt tgtggcgatt tataattcaa cgattgcttc tcgaatggta acagccgata 3547081 ccgaaccggt aactcctgaa gaccggatgg aatggttttc gggacataca gagtcacgtc 3547141 cgctctatgt ggccgaggat gaaaacggaa acgtcgctgc ctggatcagc tttgaaacat 3547201 tttatggaag gccagcctat aataaaacag cggaagtcag catatacatt gacgaagcat 3547261 gccgcggcaa aggtgttgga tcatatttgc ttcaagaagc gctccgcatt gccccgaatc 3547321 ttggcatccg ctcacttatg gccttcattt tcgggcataa taaaccaagc ctgaagctgt 3547381 ttgaaaagca cgggtttgca gaatggggac tattccccgg catcgccgaa atggacggga 3547441 aaagatacga tttaaaaatt ttagggagag agctttcatg attagtctgg ataaagatga 3547501 aaacgaaatt gaacatcata atgaagaaaa tagccttgtt gaacaggaga ctgcacctgt 3547561 tggacaggag agccgccagc tgagcgcctc cgctgtcaag tcgctatccg acattgccaa 3547621 gtggggcaaa atttctggca tcttgttaat cattatggga tcgcttgtca ctctgtctgt 3547681 tttgatgaca gtgattggcg ccatcccggg cgtactgctc attatttcag gcgtattttt 3547741 gatgcgctca gcaaaagcag ccgcggaagc cgaaggaaat ctaaccggca gcgctggcga 3547801 aagcatgctt gaaaattacg ggacatttat aaaaatgcag ctgttttatg cagcatccag 3547861 tatcgttact gtcctgatcg ggatcattgt agccattttc gtgctggtgg taatcggcat 3547921 tgctgctttt gagaacacgc cttcgtatga tgatccggat tcttattatt atgaggatga 3547981 tccggtgttt gaataatgat gagacaggac agggcatgag ttccatataa acggaaccat 3548041 gcctatttta tttgactatt caaagcaggc cggcgtaaac accaaatcct gaagcaagca 3548101 tacaatagac atctctagta gaggaaatca acaaagcaac gctgttaccc agaaatgaat 3548161 atcaaaaaaa cggatgaagt cggaatcaat ccgaaaccgc actttttatt tcgggtgtct 3548221 gcatgcaaaa aaacacaccc ggatcgtctg gaaaatctca acaatccggg tgcagatctt 3548281 ctttaataca tttttttgcg tctgtcttcc tcagtcaaaa attcaacaaa actccgcatc 3548341 gcaaaaggct cttcctttat ttgtcgtgcg taggagcttt tccgctcttc tgaaaggatt 3548401 tcgctctttt tgatcctgtt cagcatatag atgtgaaccg ttttttggat ttgtttatgc 3548461 tgatagcctg cctctttaaa aaatgcgagc ccgagcgccg ccaaaagggc gaatatgcct 3548521 gcgctgatca gggactccct gtcagctgaa gcatgaaata gaaaagcagc taaattaaag 3548581 agagagaatg cagcaagcgg aatagcaaga aaacggtaaa tgacggtttt tttcatgaaa 3548641 ggctgtacgg ccttttgaat tttttgcatt tctgttttga tgaaccccgg catttgttcg 3548701 actctgtaaa agttcatata atcctccccc tttatttgat gtttcaagct tcacgaacgt 3548761 tatcatatgt gtttatttta acgcaggtgc aagctggttt taaagaaatc tgcccgtatt 3548821 tttcacgaag aatctggatc gccgctcttt attcttttaa aatgtgagtg ttataatttg 3548881 taatgggaat cagatcactg ttattcatgg aatactaatg gcaatcttct tgataaatat 3548941 gaatgagcgg ggttacaaag tgagtatttc ttccatcctt ttatcacttt ttttcatttt 3549001 aaatattctt ttggccatca ttgtcatctt caaagaacgg cgcgatgcca gtgcatcttg 3549061 ggcgtggctg cttgttcttt tctttattcc cgttttaggc tttattttat acttattatt 3549121 cggccataat ctcagacgca agcatttgtt tcaatgggaa gaccggaaaa agattggaat 3549181 tgaaaggctg ctgaagcatc agcttgaaga tttagaaacc aagcaatttc agtttaacaa 3549241 ccgggcaacc tttgataaca aagatttaat ttatatgctg attatgaata accatgctgt 3549301 gtttacagag gataattcag ttgacgtcat tacagatgga cgggataaat ttcagcggct 3549361 gctgagtgac atttcaaagg ctaaggatca tatccattta cagtattata tttataaagg 3549421 cgatgaatta ggcaaaaaat tgcgggacgc tctcatccaa aaggcgaaag aaggtgttca 3549481 ggtcagagtg ctttatgatg aactcgggtc cagaacgctg agaaaaaagt tttttaaaga 3549541 gcttcgcgag gctggcgggc atgtggaggt ctttttcccg tcaaagctca ggccgattaa 3549601 cctgcggctg aattaccgga accatcgaaa gcttgtgatc atagacggta tgaccggtta 3549661 tgtcggaggc tttaacgtcg gagatgagta tctagggctt aatccgaaat tcggttattg 3549721 gcgggatacg catatccggc tgcaaggaac ggccgtgcac gccatccaaa cacgattcat 3549781 ccttgactgg aaccaagctt ctcatcacca tacgctgaca tatattccaa atcactttcc 3549841 tgattacggc ccaaaaggca acgtcgggat gcagattgtc acaagcggcc ctgattcgga 3549901 atgggaacaa attaaaaatg gctacatcaa aatgatttcg aacgccaagc gttccatttt 3549961 gatacaaaca ccttatttta tcccagatgc aagcctgctg gatgctttaa ggatcgcttg 3550021 cctttcgggc attgacgtta acattatgat tccgaacaag cccgatcacg cctttgtata 3550081 ctgggcgaca ctttcgtata tcggcgatct gctgaaagcc ggagccactg tctatattta 3550141 cgataacggc tttattcacg cgaaaaccat cgtggtggat gacgaaatcg cttcagtcgg 3550201 cacagcgaac attgatgtcc gaagcttcag gctgaatttt gaggttaatg catttattta 3550261 cgatatcacc attgctaaaa aactggtttc aacttttaaa gaagatttgc tagtatccag 3550321 aaaattcacc tatgaggagt atctgcagcg cccgttgtgg attcgaataa aagaatccgt 3550381 ctcgcggctg ttgtcgccga tcttataaga tgcgtaaacc cccggccttt acggccgggg 3550441 gttttcctga tggtcacagt aaatgatgat tgcctcccgc aaaaaagcgg caagaccttc 3550501 tccatattga ttgattgaat cggtaaatcg ctcgtcagtg atatacactt ccccgagtcc 3550561 tctgaaaatg tcgagtgtgc aatcgtaatg atattggcaa atatgatcgc gaaatgcccc 3550621 cacagcggcc tgaatctctg catcatcggg cccatgcttc attcgcgccg caattcgtct 3550681 gtaaatcgaa tcaaattcag ccatgatcgt gcgccaatca tctgccgagt atgcagatgt 3550741 ccttttctct gtttcttctg cgatttcctt tccatacagc tttctgactt catcagcgta 3550801 tgtctgctgg tgctcttcaa tgtctttcat gcttaatccg gcaaataaat ccctcttatt 3550861 catcgtttcc cctccatcaa cggacaaaag cgtcctgtca attgtttgaa tcatctcatc 3550921 cattctttgt tttttcttca tcaatatctc cttttgcgac tgaagtgccg ctttccggtc 3550981 aaaattcgga tgatccagca tctctttaat ctcatccaga cgaaacccga tttccttgaa 3551041 aaataaaatc tgttgcagtc tttccaggtc tgcgtcactg tacaaacgat acccagcatc 3551101 agtaagcgct gaaggattca gaagctcaat attgtcatag tgatgaagcg tccgaatgct 3551161 aacgcctgat atctccgcca cttgtttaac ttgatatttc atacataaca cctcctcttt 3551221 tttatcgtaa acaatcacgc aacgttaggg tcaatcccca aaatgttatt ttctatatac 3551281 aaaacttctc acaaatagtg tataaaagaa aagtgagtat ttttttgtaa aggggagcca 3551341 gtatacatga atcctgaaac aatgaacaaa accctcatca gcatttcgaa atggggaaaa 3551401 gctacaggca ttttatttat tattatgggc gcaattaccg cgctttcagg cgcgttcttt 3551461 tttctaatcg gtgccgtgcc aggcgtactg caaattattt ccggtatctt tttgatgagg 3551521 tcagctaggg aagcaggcca aatggctgaa cacaatagcg gacagtctga agacttaatg 3551581 ctggagaatt acgcgaaatt cgtaaagatg caagggattt atttgatcgt aagcattgct 3551641 gtatccattc ttgcgattat cgccttcttc atctttttaa tgcttgggat tgctgacggc 3551701 cttttcagcg atacgtacag cacttattaa tgagaaaaac ccggagctgg ctccgggttt 3551761 tttattattc cgcttcgctt accactgtga agcgttcatt tttgtgttcg ggatgttcaa 3551821 gctcgtccaa cacggcaatg gcataatctg catagctgat atagctgtct ccttttgcat 3551881 ttacgatgac attgtctttt cctttttggt aagagccagt ccgttttcct gctggatcaa 3551941 aaaatgccgc aggactgagg aacgtccagg aaatggagtc tgtctgctgc aaatctttca 3552001 ggttctcgcc ttgatttgat gcagttggca aatattcttt cggaaattcc ggcgtatcca 3552061 ttaaacgggt tgttttggct tcatcaacaa acaggcttcc cgctccgcca acaacaagca 3552121 atcttgtgtg cttcgcgtcc tttaaaatgc tgatgagtgc tcttcctgct tcaacatgaa 3552181 gatgttcttg gccgggtgct gctccaaaag cgtttacgac cgcgtcgaaa ggcttgatgt 3552241 cttccgcagt cagttcaaac acatcttttt ccaaaatcgc tacgtcttgc tcctgcactt 3552301 ttgaagcgtt tctgacgatg gctgtcactt catggcctct ttttttcgct tctttcaaaa 3552361 tctcgtttcc cgctttcccg cttgcgccta taataccaat tttcattttt catttcctcc 3552421 ttatttgtaa caattttagt tacatgttag cggtgagaag tcatcccttt tgattaaaag 3552481 agatgattca taacatcttt taatgacttg cttgccagtt cattttccat cgctctttgc 3552541 acactttcaa acgtttcatc cagagcgttc tgaatttttt tccctaccgg acatttcgga 3552601 ttcgggtttt catgaaccgc aaagagttct tcttgctttt ggacagcccg gtacacttct 3552661 aaaagagaaa tatcagcagg atcttttttg aggcttgcac ccggcacccc ggcgcgtgat 3552721 gtgagaatat cagctttttt cagcaggctg atcattcttc gcacaactac cggattcgtg 3552781 ttgacactgt ctgcaatgat ttctgaagat gttttttcat ccatcgagat gagggataaa 3552841 atatgaatgg caacagcaag acggctgtta atcatgtttt ttcaccaccg ttgtaactat 3552901 aatagttaca tttgattcgt ttgtcaacat ctaatataca ctaaatacat gggttttgtg 3552961 caccgttttt agtcaataga acggccggat gcactccggc cgcgtcttat caaaataaga 3553021 aatatctttg tccaagtggg acataatcga caggctggca agacaattcc tccccgtcag 3553081 caaagacctg ataggttttt ggatcaatct caatcttcgg caaagccgaa ttcagcttca 3553141 tatccagctt gctcagcttt ctgatatttt tgactggaga aatccttttt tccagcccta 3553201 agctttccgc cacaccacgc tctatgcttg cctgagacat aaatgtaatc gaggttgagc 3553261 ggttggcttt tccgtaagac gcatacattt ggcgcatgaa aaccggttca ggagtcggga 3553321 tggacgcgtt cggatctccc atttgcgcac gtgcaatcat gccgcccttt aagaccagtt 3553381 ccggtttcac gccgaaaaat accgggtccc acagaacgag atcagcaagc ttcccttttt 3553441 ccaccgagcc gacctcatgg ctgagcccgt gcgtaattgc cggattaatc gtgtatttgg 3553501 caatgtaccg ttttgcgcgc acattgtcat tcccgttttc accggcaaga gcgccgcgct 3553561 gttttttcat tttatcggct acctgccatg ttcggatgat cacttcaccg acccgcccca 3553621 tcgcttggga atccgatgat gtcatgctga tcgcacctat atcatggaga atatcctccg 3553681 cggcaatcgt cgccgccctg attctggaat ggctgaatgc cacatcttca ggcactttcg 3553741 catctaaatg gtggcagacc atcatcatgt caagatgctc atccatcgta ttaacggtat 3553801 aaggaatggt tggcgttgta gatgacggca gaatgttcgc gtaagaggcg agcttcataa 3553861 tatccggagc gtgaccgccg cctgcccctt caatgtgata agtatgaata acccggtccc 3553921 cgatcgcgtc gagcgtgttt tccaaaaagc ccgcttcgtt aatcgtatcg gtatggatgg 3553981 caacttgaat atcagcctcg tccacgactt ccatacacgt tttaatggcg cttggcgtcg 3554041 ttccccagtc ttcatggagc ttaagaccga tggcgcctgc ttccacctgc tcgatcagcg 3554101 gcgctttatc ggatgcattc ccttttccta agaagccgac attgatcgga aactcctcgg 3554161 ccgcttccag catcctcgcc atataccacg ccccggacgt acatgttgtc gctttgcttc 3554221 ctgtagcggg tcctgttccg cctcccaaaa gggtcgtcac acctgaagaa agcgcaactt 3554281 ccatctgctg aggacaaata aaatgaatgt gcgtgtccac tcccccggct gttaaaattt 3554341 tgccttcacc ggaaatcacc tctgtccccg ctccgatgac catgtgcgga tcgactccat 3554401 ccatgatatc aggatttccg ctttttccga caccgacaat ccggccgtct ttcacaccga 3554461 catccgcttt gacaatgcct gtgtaatcca atagcacgac gttggtgata accaaatcca 3554521 aagcgccgtc cttccctgtg attctgccgt tttggcccat gccgtctcgg atagtttttc 3554581 cgccgccaaa gatcatttct tcaccgtata ctgtgaaatc cttttcgact tcgatccata 3554641 aatccgtgtc gcccaatctg attttatcgc ccgttgtcgg gccaaacagt tccgcatatt 3554701 cctcccgtga cattttcatc ggattacacc ctccatccag ccggcttgtt ttaagttggc 3554761 caacgttttt tctttgccgc gttcatcgat aaacgtgtcg gccattccgt tcagccctct 3554821 aattgtcttg cgtcctctga tttccactag tgagaccgtt ttctgctctc ccggctcaaa 3554881 acggaccgac gtgcctgatg gaacatcaag acgcatgccg atcgccagct cacggtcaaa 3554941 taataaagcc ccgttggcct ccgcaaaatg aaaatgcgaa ccgacttgaa tggagcgtga 3555001 tccggtgttt tttaccgtta cctcccgtat ctcacggcct tcattaatcg taatggttcc 3555061 ctcagcaatt tgaaatgctc ccggcttcat gacttcacct ccgcagaaat tggctgatgt 3555121 accgtaacaa gctttacacc atccggaaat gtggcctcca cctgaatgct gtccagcatc 3555181 tcaggcacac cctccatcac atctttttcc gttaatacat ggcggccggc ttccatcagc 3555241 tctgctactc ccttcccatc acgtgcgcct tccataataa agcaggtgat ataagcagca 3555301 gcctcaggat agttcagcag aacgccccgc gcctttcgct gtttggctaa ttcccccgct 3555361 gcaaaaatga gcaatttctc ttgttcaact ggtgtcagtt tcatctgtag tcctccttct 3555421 tttgtcatat aaagcagatg cggctactac gaatttgcgg aacagtcagg cgggacatca 3555481 cctccctttc ttcgagaatg ggggtcatac ggtaagatgc ctttcaaagc ggcatgccgt 3555541 ttcttcatca gccttgccat ggtcaacaac cgttcccctg tcgatcacgg aaagatcaga 3555601 ttaacgcgtt ttccagactg cgctcgacta agataacaaa tgtctttttt tctggaaatt 3555661 tctataataa cttgtctgac tagttcgaca attaaaatct gaattccttc caattgttta 3555721 ttaagtaaaa tatttttcag atttaccatc agcgctctgg tgattgcaag ctgctgctgt 3555781 tgaccgcctt ttcgttttga acaaacgttt gattaaaaca aatagccccc tctgtttagc 3555841 cggagtcggc ctaatacagc gacaatctgc cccgggcgaa gctaaggctg tgcaaaacca 3555901 tcgattgatc ataaccagac gttacattcc tgatggcagc ccgttgtttt gctccgcaac 3555961 cggaagcatg gcatggaggc cagtctgagg cgccgacctc cacgataccg agaacccgac 3556021 tattgccatt aactccgcat catggacggt cacttcgctg atcgccaccg ttcctcttaa 3556081 tgagtgaaga attccggcct tcactgaatc cccgcttgtg tcgatatcaa ctgttttctc 3556141 gcactcccgt ggcttccgac actttcttcg gtgcagtaca ttccgtcatc aaaacccctt 3556201 tgtttgattt cttcaaatga tgttataaaa gtttacaact tatgtcatca ttatatagaa 3556261 gaggcctatt aattcaaaga atatttaaaa aatttagtta ccttgaccaa atcagcttct 3556321 ttttttgtta tatttattca catcagaaaa agcgaaaaaa aagacaagaa acatttcgtt 3556381 tcctgcctct tccgtacgat taatctttat ctgaaaattt atccttggct ttcccgatat 3556441 ccttttggat ttcgcctttt gccttatctt ttttgccttc agcctgcatg tccgttctgt 3556501 cagccatatc tccgacttta tccttcactt ctcctttggc tttattgaag ccgcccttca 3556561 ttttgtcttt tacactatcg ttacccatgt taattctccc ctctcaatta tgtgtgtact 3556621 tgttaacttc ccgatctgag aggcaataaa cattctaatg ttatttatcg atttcgtagc 3556681 gctctccgta acggagcacc ttgtatatcg ccagcccgtc tgatgacttt ttctccgaat 3556741 atcggaccgg cagcagggca aaaaacacat aatacgtaga aaaatagaca aactgataga 3556801 aaaacacatt cggctttaat acactgtgta taatcagcag attgattgca aaaatcgtga 3556861 tgaggttaaa caagcagccc cctgcataca cgagtgcatt tgagaatcga ttgtcaattt 3556921 tcaactcccc gtaccggcaa aaagaatcga taaaataaat cgttctgaac cgtatgggtc 3556981 caattttaag cagcgttttt cccatgccta tatccaacga tccctttccg ccaaaaataa 3557041 aagccataaa gctgtgccct gaaacatgta taatctgtac aagcggcaga acaatgagga 3557101 aagaccacag aaacttcacc atatcattaa aaccaaacat tgaattcccc ctcacatgca 3557161 tatctgcatc ccaaaacggc ttttgttcaa aaaacagtgc tgtagcgatt tttcctgttc 3557221 tccccggaaa taaacgttcc gatgctcccc tttttttgca taaaaaaaaa ccatctgcca 3557281 gcagatggtt ttgtctcata cttcatataa acaatcgttc ctttgaatca tctctctcat 3557341 gctgaccgct ttttcataaa aatacaccgc ttctttatat tgttcgcgat gactgaaata 3557401 agaggcagca tctaaagcaa attcttcaat atatacatac aggccctttt cttccatata 3557461 atcaaatact tcttgaatca tattcaaatt gacagattcc acatataatg cctgcagaaa 3557521 tttatatttt gccagactga agaagtcgtt tcgtttttgg gcaatggcaa tccctttttc 3557581 atagtaccgt atcgcggctt cgctatcttg ttttttgaaa agaacgcgag tcaggctgaa 3557641 gagcgctttt ggaagctgtt ccagctgata atcctcgaag acaggaagcg ctttttcaaa 3557701 gtattcggcg gcctgatcca gctccccctt gtcatcatag caattaccaa tattataaag 3557761 ggctgatccg atcaaacggg gctgtccttc caataaagca aggcgatacg cgtcatctaa 3557821 atgttcaagc gctttttcat aatttctgta gtcaatgtag tttcctgata tgacgaaatg 3557881 gcattgaatt cttctgactc tgtaaaaatc gtgagcctta tacgtctcca gcgcctgtac 3557941 ggcatggttc atggaaaagt gcgtctgctt cataatataa aagacttccg ccactttaaa 3558001 atgaaattcc gctctttcaa tttcatcttc tacaaacgca agcatcttct cagctttccg 3558061 ataaaaggat atagccgaga tgtaattgtt ctgttcaaat tcgtacattc ctctaaacaa 3558121 gtgaaaataa tactcagata atccggagat gctgtcctga ttgctttcca gcgttttgat 3558181 caattcacga tattgaagct gagattcctc gtgcaggtca ggctttacat aatccagcat 3558241 aatttggtgc cggtagctga tcagctgata atacaggaga agcagctgat cctcttccat 3558301 ctgttcgata tctagatcaa tttcttcttt cagttttacg gcatcagcca cttgaaatgc 3558361 taaaatgtgc ttataccact tattgatttt cactcctact tgagatgacg ggatctcgta 3558421 cgcggccatg cccctccaac cctttctatt ttctaattgg ttatatttta tcataatgta 3558481 tggctttgga attaaatttt cttacaatga ttccttcttt atgcctatcc ttatatattt 3558541 cggtttttct acgtattttt tgcactcgga ttctaataaa aaagcttacc ggacagtgcc 3558601 gataagcttt tgacttcaaa ttaaccgcca atataagaca tttccacttt ctttttgcca 3558661 gatgcttttg atagcgtacg atcgactgaa tactgatcga tccgattttt ccatactgtc 3558721 ccgatcattt ctgatagttc gtcatcactt aattcctggc gaaccggagc tctgaggtca 3558781 aatccgcttg aagcgaataa gcaggtaaac agctctcctc tcgcagaaag acgggctctg 3558841 ttgcaagatc cgcagaatgc atcagataca gatgatatga cgccaatttc tccggagccg 3558901 tccaagtagc ggaatctgga agccacttcg cctatataat taggcgctat cggctcaacc 3558961 ggcatgtgtt tattgatcaa atctatgatt tccgcctttg tcatgacgtc tttcttttcc 3559021 cattggttgg tgttgcctac gtccataaat tcaatgaatc tcaggatatg ccctttttct 3559081 ttaaaataac gggccatagg cagtatatct ttttcattga cgcccttttg aacgaccata 3559141 ttgattttaa caccgagccc cgcttgcttc gccgcttcaa tgccttccag caccttgctg 3559201 acagaaacac cgcgcccgtt tatcttctta aaacgctcgt cttctaaaga atcaaggctg 3559261 atcgtaaccc ttttcagccc agcctccttg agcctcttag cataaacagg cagcagtgat 3559321 ccgtttgtcg tcatcgcgat gtcacgaata cccggtatgc gggccagttt tttgattaat 3559381 tccggcatat cctttctcat gaggggctct ccgccggtca agcggatttt ttcaacgcca 3559441 aatcttgtga caaacaatgt cgcaagccgt tccagctcct caaatgaaag cagctcctct 3559501 ttctttaaaa aaggataatc cgggccgaat aattcggcgg gcatacagta cgtgcatcgg 3559561 aagttgcagc ggtctgtaac agaaatgcga aggtctctca gcggtctgtt tcttttatcc 3559621 aacatctgac gcgactctgt aatcatagct acagcccctt cctactccct gattctctca 3559681 gggtgtgtat atacattaaa tgatccgttt ctgacaaatc caatcgctgt gatattcaat 3559741 tcttcagcca tttgaatcgc aagctccgtc ggggccgatt tggaaatgac aatcgacacg 3559801 ccgattttgg ccgcttttaa caggacctct gatgagattc tgccgctgaa cacaatcagt 3559861 ttgtcgcgta cggacatccc gtttagaagg cagtgtccgt atagtttatc aagtgcgttg 3559921 tgccgaccga tatctgtgcg catcaacaga agcttctctg tgtcgcaaag cgccgcatta 3559981 tggacgcctc ccgtatcctg aaacgtcccg ctcccttgct gcatgtcttt cataagcgcc 3560041 agacatgcct caggcgatat cttgatttgg ctgacagccg tcttggctgt tttgacatcc 3560101 tgctgaaaat aaaaatgacg gccctttccg cagcatgagc cgatcacccg tttcgtataa 3560161 tccttttgat ccaatgtctc agggtgaacg aggtcgacat atacaaaacc gagactttca 3560221 tctattgtaa accttttaat ttctttttga aatcgtataa caccctctga tgcgagaaat 3560281 ccgatgacaa gctcttcgat atgctcaggc gtacaaacga gcgtcacaaa ttcactgcca 3560341 ttcagtatca ctgtcaaagg gaattccgtc accatccggt cttctacttt gcttatttcc 3560401 ccttgttcat agcgccatac atccctgacc gcagttactt tatcgttcaa tgtctcttcc 3560461 cctccgcaat gttcctgcct ttatattttt tcacactcct cggattttgt cgaattctga 3560521 gacacaaaaa gagccctcta tataaagggc ttttacagga tgtgatgacg gcggtgttta 3560581 ggcaggacgc ctaagcattt agccgccgtt ccttttataa cacgtgagca ccaatgtgca 3560641 ttgacaacga acgcggggtt tgtcgacacg ctgagacacc tctgtataaa ggactctatg 3560701 tttgattatg ctgattcttt ttcagaaccg taaacagcac aatagctgcg atcaaggtga 3560761 gaatgctgac aaaaaagaag gctgccagtt ttagaagaac accaagcaat ataaatgcaa 3560821 cggtggctat aagaaaaatc attccgaata atttcatatg ttcaacccct ttttagggta 3560881 tcattcccgc ccaaactgtt tttaaaccaa taaaaaaggc gcctggggga gcgcctgatc 3560941 tttaggttcc ttactcagta aatttttgtg cttctttttc ccaagcctgt tcgaactcat 3561001 ccgcactgtt cgctgaaata tattctccgc cgccagcgac agctgcttgt ttcatctctt 3561061 cattaccctt gacatcaaag ttgaagccaa tgatgtttac aatcgtatcc acatttgatg 3561121 cacggagctt ttcgatttcc gccgcagggt ctccgccgca cgtttcttca ccgtcagtga 3561181 ttaaatacac cacgtttttc ccgtctgcgt caaatgcttc aaattctttt cttgtgtctg 3561241 caagtgcttt ggcaatcggt gtccatccag tcggcttgag ctcactcaat gaattgtcaa 3561301 acagagaccc ttcatatgga tgaaggccgt aaatggtttc cgtcgtactg cacgaaaggg 3561361 ctttaccgga cagtttattg ttccctgcat gcccgaaaac gcgaagcata agatttgtat 3561421 cctttggaag aagttcggca aaagatttta ctgatttttt ggcaatgtct attttgcgct 3561481 ctcctcctgt tttttgaacc atgcttccgc ttccgtcaaa caaaacagct acatttgtat 3561541 cagcctgttt ctcagcggca aaagacgggg aggcaatgga aacagtcaac aatccaatga 3561601 taccggcagc cagcaatttt ttcatatgat tacttccttt ctttttcata ttttccaact 3561661 atatgttgga ttcttcttta tgctagaata cgaaaatgca aaaagatata ggacatgctg 3561721 ccttttgtgc tgctttcacg atctgtccaa aatcgcttga aatgccgttc atttttagcc 3561781 atttccgccc agaaagcata aacagcttgt gtgatcattc attctttttt cgccttgatt 3561841 atgacagaaa aacggaaatc tgctactatg ctacaggcag acagctaatt agttttgaag 3561901 tttttgttac atacaaaaag aggctgacca tcaccagcct cttttttctt atttagataa 3561961 cattagtgat tgctgagtga aaattttctc aacatctttt tgggtataag ccgggaagta 3562021 ttcaccgccg cctactttcg caattgcgtt cagctggcct ttgtatccct ctttataatc 3562081 aaagccgatc acattaacag tgatattgtc tttttgcagt tcctttgctg ttttaatcgg 3562141 gtttcctccg cacgtttcct caccgtctgt caacagatac accacttttt ccccttttgc 3562201 atcaagctgg tcaaaagaag atttcgcctc gttcagcgct ttggcaattg gcgtccagcc 3562261 agtcggccca attgtattga gagaattgag gaagctttgc tcgttaaagc tttggaagcc 3562321 gtatacgttg cgaatggctt cacatgactg aacttttccg gaatttttat tgtttccttc 3562381 agagccaaac acgctcattt tcacctgagt tccttctggc aatgagctcg caaactttga 3562441 aatttctttt ttggctgaat taaatttaga tacaccatct attcttttcg ccatacttcc 3562501 gctggcatca agcaagaccg ccacgttcgc cggcgcttta gcctccgttt ctgtcttttc 3562561 agctgcaaaa gcaggtgaag ttaatccaaa aagcaatcct gtcatcatga tcagtgaaaa 3562621 tcttttcttc atgttcgtac ccctttacca atttgtttct gcgtgcagat gttcaacgct 3562681 gaacataatc tatcgtaatc aacaaaaacc gagaaataaa tagggcgggc ttccccattg 3562741 ctgttgttta cttttgcata gaaacctatg tttttattag tgatttccac ctaacgcccc 3562801 tatgaaaaga gaagattgtc cgcctttcgg ctttcgttat atgagtctgt cgaagtctgt 3562861 cgacaaatgt ggatgacttt accacaatct caaagcctga aatcaggaaa aaaggactga 3562921 tccttaaaga cggtcagaag ctcctctaaa ccgtttcagc tactcttaga taaaagatat 3562981 tcaggaacag aaaaagacgc ccaatgagcg tctttttcta ctttttcgcc atatatttat 3563041 tcaaaaacgc atctgcctca gaaatttgtg tgccttggta atagtacttt acaatgtcat 3563101 caaccgtttt gccttctttg gccataaaat tcgctccgta ttggctcatc cccacaccgt 3563161 ggccaaatcc tctcgtcgtg actgtaattg tgtctccatt tcgcttccat tcaaaatcgg 3563221 cggagttgag acccaacttt tcacgtatgt ctcttccttt cagcgtcttg ccgttaatga 3563281 cggcagttgc gacctggtgg cccggtgtct cgccggtaat cttccctact gcgctagatc 3563341 catccagctt gacgccaagc ttttgctgaa attctgccgc tgtaaaggtt ttcgttgcct 3563401 tatatttcgg agacttttta tcccatgggc ttttgacgct ttttaaatat gggatagcac 3563461 ttgtccaata agcttctgca ttctctgtgt agccgttgct tgtggagaaa aaggatgctt 3563521 caatcggctg gttgttgtac gttaagattt tgccttgcgt actggctacc gcatctgtga 3563581 ttttcttcag ttttgtctca tagcttgtgc cccactgttt tttcagctcc gctttgcttt 3563641 tatacacctg gaacatctgt gtatcatcca ccagtgagcc tttaggagct tctaccgctg 3563701 aatttgacac catcagtctg acaataaatg ttctggcggc aagcgcctgg gctttcagcg 3563761 cttcaggttt aaaggttgcc ggcatttcgg aggcgacgac tccaatcaca tactcttcaa 3563821 gcggaatgtt ttctacggat tgatttgcgg ttcgatagac gggaatagaa acaggtgatg 3563881 ctttcaatgt ttctgctcct ttcgatgctg gtttcgtgct gactgctgtc ttttctgatt 3563941 ctacgctggc ccccgcttcc ttattatgct ggaatggtat aaccaagagt gtgggaacca 3564001 agagaatcaa tgcacatagt acggatagtg tgattgcgaa ttgtttcata ttcagctgcc 3564061 tcctgctcgg gattcgactc tagtctagtc tatgggcagg gacaagctaa tatgactctc 3564121 gttttggaca gaaactttat ttgtcattta cgtattcttt tttgctattt tgcgcataat 3564181 gatgataata cacaaaaaat aaaaaaccag tatgccagag tgacatactg attttcaagt 3564241 aagtttatgc atttaagtca gaaacgactt ctttattctc ttgctcagaa gcagactcat 3564301 catttacacg ttcgatgtct gcgcccagag cggcaagctt ctgatggaaa tcaacgtaac 3564361 cgcggtctaa gtgcttcaat tcagtaacac gtgtgtgacc ttcagccact aaccccgcaa 3564421 gaatcagcgc tgcacctgca cgcaaatcag tcgctgcaac ttcagctccc tgaagctgta 3564481 caggaccgtt aatgatgaca gaacgtcctt caatcttgat atcaccattc atacggcgga 3564541 attcttccgc atgcataaaa cggttttcaa aaacggtttc tgtaatcatg cttgtgccgc 3564601 ttgcacgaag cagaagcgcc atcatttgtg actgcatatc agtcgggaag cccgggtgag 3564661 gcattgtttt gatgtcaatc ggtttaagct ctttcgggcc gatgacacgc agaccttcac 3564721 cttcatcctt aattgttaca cccatctctt ccatttttgc aattaaagag gtgaggtgct 3564781 caggaaccgc tccttttact aatacgtttc cttcagtgat tgcagcagca accataaatg 3564841 tgcccgcttc aatacggtca ggaataatat ggtgttttac gccgtgaagc ttttcgactc 3564901 cttcaatttt gatggtgccg gtgccagctc cgcggatttt tccgcccatg ccgttgatat 3564961 agtttgctaa atcaacgatt tcgggttctt ttgccacgtt ttccagcgtt gttgttcctt 3565021 cagctagagc ggctgccata atcaggttct ctgtagctcc tacacttggg aagtccagat 3565081 aaatttttgc gccttgcagt cggcctttta cttcagcttc aatgaagcca ttaccgactt 3565141 tgatttctgc gcccattgct tcaaaacctt ttaaatgctg atcaatcggt ctggaaccaa 3565201 ttgcgcatcc gcccggaagt gcaactcttg catgacctgt acgcgcaaga agcggcccca 3565261 tgacaagcac agacgcacgc attttacgaa catattcaaa aggtgcttca gtttgcaaag 3565321 cgtatgaagc atttacagtc acttcattat tttcaaaatg cacatctgct cctaaatgac 3565381 gcaacacttc gttaattgta tatacatcgg agagcgtagg tacatcacaa attacgcttt 3565441 tttcttcact tgctaataaa gatgcagcga taacaggtaa aacggcattt ttagcgcctt 3565501 caactttgac tgtgccgttt aacttctgac cgccgcggac gatgattttt tccaaggtat 3565561 tcccctccgc gtccctaaat tctctatatt aatattcagt cgtaacgatt ggtgtgccaa 3565621 ccgtaacggt atgttttccg cccattcctg cacttctaag tgcaatttgc aaattcattt 3565681 tatgtttcga ggtcataatg tactcttccc actcatctgt aaacgcagaa atagaaacga 3565741 aatttggctc aactacatgt tctactgatc ttgcttgaaa ttcatttaat aactgatttg 3565801 cttttttttg caaaacaata ttcatattat catctaagtg accatttaga caagtaaaaa 3565861 taactacttt ttcttggaat atcccaagtg tctcccgttc aaactgttca tatgtatcat 3565921 tccagctatc cggtgtctct agactcattt gctcatataa taaatacgaa gttggattgt 3565981 gttttttgag ggttgtgaca agctgcagtc taaaagaagt acgatttttt ttgtcagtat 3566041 atgtgccaat tgcctttatc attttatctt cccgtgcaat cacccaatca tattgacgat 3566101 actcttgttt taaacgttgc actttttgat aaaattcttt ttcggtcagt gacaagtttt 3566161 gttttgcatg caatgtccac ttatctattg acacatcttg acgttccatc ccctctgcca 3566221 tctgtgctaa cggcgttaat tcactcgcat gaatggtatg gaaaacagca atgacgaagc 3566281 ttaacatgac ggaaatgata atagcgtggc ttacttgttt tttcttcatg ttcatctctc 3566341 ccccttatcc ccagttttac cggaggcaag aggcgccata cgtaaaaatc ttcgtcaaaa 3566401 ctcgagctat tcgcttcaac ccgcttctcc caaccattta ataatgttca aaacctatta 3566461 aaatagatag ggaagctgct gtgaataatt gaggtaatct aaaaagaaat tggcaacggc 3566521 cgttccaatg gcgattgtca gcaaaatcat caggagtctt gcctgcacga ctttgccttt 3566581 tttgattaac ggatctatat tgacggcttg caacgcccac caagtcactg ctataaaaat 3566641 caggtgaacg acaatgccga ttgcagcctg ctgtcccaat acactcatct attacactcc 3566701 tttctctgcg ttcataccct ttcttattat ataagaagca cagataaaga tgatacattt 3566761 tatacagaac ggaataatca gccaaatcta gggctaatcc ccgcttaaag tgcgattctt 3566821 ttacatggta tactttattg gaaaggagct ggcaaatgtg aatcattctt tttttcagcc 3566881 tgaaaagcaa tatggtgagg acctgccaat ttttgatcag gaatgggaag caattgcatt 3566941 ctattatgat tatagacagt cacagattga agaactgaat gaattgtgtc agttttttaa 3567001 catttctctt acctatacga gagaaagcct tgaagagctt gaaaacctct attttcaaag 3567061 tatacaagaa cttttgcttg ctgattggaa tcttcctatt gaagaattcg agaaaatgat 3567121 cagtgtttat cttatagatt gtgtgattgc ccgccatgaa gatgctgaat gggttgtaaa 3567181 accttatccc tataaagacg gcgcttatac acttggcttt agaagacatc gcaaatcgtg 3567241 gcatacaatg aatgcctgtg atggtttata cctgcgtcca aaagaggatc gcccgttgct 3567301 gtcgctgttt gattctcttg tgcgttcata aaaaaatcct tctcataaag agaaggattt 3567361 tttcttattt ccctgctaca tccaatctgt tcaaagcccg ctgtaacgca agctcagccc 3567421 gacgaatgtc agtatcatct gattgagaat tcaaacgctc ctgcgcccgc tggcgtgcag 3567481 cttcagcgcg ctctttatcg atgccttccg ctgtctcggc agcctgggca aggatggtga 3567541 catgatcagg acggacttct acaaaaccgc cgctgacggc aaccatttca gtctgcccgt 3567601 cttttttcag acggacagcg ccgattttaa gaggagccac ggttggaata tggcctggca 3567661 aaataccgag atcgccgctt tcggctctca cactcaccat ttcgatatcc gcatcgtata 3567721 ctgggccgtc gggagtaacg atattgactt taacggtctt catgctttta ccctcctagg 3567781 accagattaa acttctacac ccatttcttt tgctttctca acaacttctt cgatacggcc 3567841 tacaagacgg aatgcatctt ctggaagatg gtcatattta ccggctaaga tttctttgaa 3567901 gccttgtacc gtctctttta caggcacgta agaacctttt tgtccagtga actgttcagc 3567961 cacgtggaag ttctgagaaa ggaagaactg gatacgacgt gcgcggtgaa cgacaagttt 3568021 gtcttcctcg cctaattcat ccataccgag aatcgcaatg atatcctgaa gctctttgta 3568081 acgctgaagc gttgactgta cttcacgcgc aaccgcatag tgctcttctc caacaatttc 3568141 aggagcaagg gcgcgtgatg tagatgccaa cggatcaacc gcagggtaaa tacccatttc 3568201 agttaattta cgctcaaggt ttgttgtcgc atccaagtga gcgaacgttg tcgccggcgc 3568261 cgggtcagtg tagtcatcgg caggcacgta gatcgcctgg atagatgtaa ctgatccaac 3568321 gttcgtagac gtgatacgct cttggagctg acccatctca gttgcaagcg tcggctgata 3568381 accaaccgct gaaggcatac ggccaagaag ggctgaaacc tctgaacccg cttgtgtgaa 3568441 acggaaaatg ttatcgatga agaacagtac gtcctgtcct tgtacatcac ggaagtgctc 3568501 agccattgta aggcctgtca aagcaacacg catacgtgcg cccggcggct cgttcatttg 3568561 tccgaatacc atggctgttt tgttgattac gccagagtca ctcatttcgt agaaaaggtc 3568621 gttcccttca cgagtacgct ctcctacgcc ggcgaataca gagataccgc cgtgctcttg 3568681 cgcgatgttg ttgattaatt cctggattaa tacggtttta cctacaccgg caccaccgaa 3568741 caatccgatt ttaccgccct taatgtaagg agcaagcaaa tcaacaactt taatacctgt 3568801 ttcaagaatt tcaacttctg ttgaaagctg atcgaatgaa ggcgcctgtc tgtgaatcgg 3568861 atcctttttc gcatccgcag gaaccggctc attcaaatca atattttctc cgagaacgtt 3568921 aaatacacgt ccaagtgtta catcaccaac cggtactgag attggcgctc ctgtatctac 3568981 agcttccata ccgcgctgaa caccatctgt agatgccatt gcgattgtac ggactgtatc 3569041 atcacctaaa tgaagagcga cctcaagcgt taaatcaata cctacttcgt tttcacttgc 3569101 agctggctgt gaaattttaa tcgcattata aatttcaggc aagtgaccgt cttcaaaacg 3569161 cacgtcgacg accggtccta atacctggct aacgcgtcct ttcttcatcg ctatccctcc 3569221 tgacaaaatc tttctattct aaagcggctg ctccgccgac aatttccgta atttcttgtg 3569281 tgatggctgc ttggcgagcg cggttgtaag aaagcgaaag tgaatcgata agttccttcg 3569341 cgttgtctgt cgcgtttttc atcgccgtca ttcttgcagc gtgctcactt gctttactgt 3569401 caagaagcgc accgaagatt aagctttctg catattgagg aagcaaaacc tccagaacct 3569461 cctcttcaga tggttcaaat tcataagacg ccgttctttt tccgccgccg ctgcccaaat 3569521 cagataacgg cagaagtttt ttctccgtta cttcttgagt aatggcgctg acaaaatggt 3569581 tataaacaag gtgcaattca tcaaacgcac cgtctataaa catttgaatc gtttgacggg 3569641 caagatcttt aatttctgta aacgttactt catctccaag tcctgttaac tcggaaatga 3569701 tcggaatctc ccgtttctta aagaaatcac ggcccactct tccgatggca atcaccgcat 3569761 actcatcctt agactgatga cgttcttgca tggcctgata agcactccgt aaaaccgaac 3569821 tgttaaaagc gccggcaaga ccgcggtcag acgtaatgac aaggtatgcc gtttttttca 3569881 cttctctgct gagaagcatc gggtgcttca cgttgccgga aactcttccg acgtttgaca 3569941 caacctcttg gattttatcc atatatggca caaatgattt tgcattgttt tcagcacgat 3570001 tcagcttagc cgcagatacc atctgcatgg cttttgtaat ctgacttgtt tttttcgttg 3570061 acgtgatcct tgacttaata tcgcgtaatg aggccaaaga tttcaccacc ttttctcttc 3570121 atctgcgtaa aaagagagaa aaagagaacc tttttctctc atcagcattc gagttagttg 3570181 cttggtgcaa atgtgcgttt gaagccttcg attgcagctt tgaagtcttc atcagcagga 3570241 aggtttcctg ttttcgcaat tccgtcaagc aggtctttat ggttttggtc aaggtacatg 3570301 tagtactctt cttcaaaacg tctgatatcc gccacaggaa tatcatcgag atatcctttt 3570361 gtcagcgcat aaagaatagc tacttgcttt tcaaccggaa gcggcttgtt cagatcctgc 3570421 ttcagcactt caactgtacg cgcaccgcgg ttcagttttg cctgagtcgc ttggtcgagg 3570481 tcagaaccga attgagcgaa tgcttccagc tcacggtatg acgcaaggtc aagacgcaaa 3570541 gtacctgata cttttttcat cgctttgatt tgcgctgagc cgccgacacg ggatacagac 3570601 aatccggcat tgatcgctgg acgtacgcct gagaagaaca aatcagattg caggaagatc 3570661 tgtccgtcgg tgatggaaat gacgttcgtc ggaatataag cagagatatc tccggcttgt 3570721 gtttctacga acggcagagc tgtaattgat cctgcgcctt tcgcgtcgct aagctttgct 3570781 gcacgctcaa gcagacggga atgaagatag aatacatccc cagggaacgc ttcacggcct 3570841 ggcggacggc gaagaagcaa ggacagctca cggtaagcgg ccgcttgttt agaaagatca 3570901 tcgtatacaa caagaacgtg cttgccgttg tacataaatt cttctgccat tgtaacccca 3570961 gcatacggtg ccaggtacag aagcggtgcc ggctgtgacg cagacgccgt tacaacaatt 3571021 gtataatcaa gcgcgccgtg tttacgcaat gtttctacta cgccgcggac tgttgattct 3571081 ttttggccga tcgcaacata tacacagatc atgtcttggt ctttttggtt caggatcgca 3571141 tcgatcgcaa cagatgtttt acctgtttga cggtcaccga tgatcagctc acgctggccg 3571201 cggccgattg gaatcagtgc atcgatcgct ttgataccgg tttgaagcgg ttcatgaacg 3571261 gatttacggt ccataacgcc tggtgcaggg ctttcgatcg gacgagtttt gcttgtcaga 3571321 atcgggccta gtccgtcaac cggctggcct agcgggttta caatacggcc gattaactct 3571381 tcaccaacag gaacctccat gatgcggcct gttcttttta cttcgtctcc ctcacggatc 3571441 tcactgaaag gtcctaagat gacgatacct acgtttgatt cctcaaggtt ttgagccata 3571501 cccaaaacac cgtttgaaaa ttcgacaagt tcaccggcca tacagttgtc aaggccgtgc 3571561 acacgtgcaa taccgtcacc gacttggatg actgtaccta cgtcttgaac ttcaatatca 3571621 gattgataat tttgtatttg ctgttttatc agcgtgctaa tctcttcagc tttgatgctc 3571681 acttaggttt caccccttct atcgattttc cccggctaat tgacgttcaa tgcgctgaag 3571741 cttcccgctt acgctgccgt cataaatccg gtttccaatg cggactttaa taccgcctat 3571801 taaatccgtc tgcacttcat ttctgattct cagtgaagcg actccggctt tttttgcaaa 3571861 cacttgtgat aatggtaaca tttctgcatc cgtcagcggt ttcactgaat atacgattgc 3571921 gtcttctgtt tgacgggcca catttgcgag tttgataaac tcatctgtga gctcagggac 3571981 aatcgcggca cgatggcggt caatcaaaag aaaaatcgta ttgagtacgg actgtgacaa 3572041 agagccaaat gcattttgaa tcagctcttt tttcttcgca gccggcacct tcggatggtt 3572101 caacacatca ttaagcgctt tttcattttg aaatacttgt tttacaacaa ttagctcttc 3572161 ttctacttga ttcagctgag cggactcatt ggctatatca aaaagagctg atgcatatcg 3572221 tttagagaca gctgatccac tcatcggctt tctcctacct ctttaagata gtcctggatc 3572281 aatttctctt gcgcttgttc atccagttct ttttcgatca ctttcgacgc aatcatgaca 3572341 gaaagagacg ctacttgctc acggagagca gaaaccgcct gttccttttc cttcacgatt 3572401 tcagttcttg ctgcttcttt cagacgttca gattctgcac gtgcagcctg aataatctct 3572461 tctttttgct tctctcccag tttctttgcg ttttcgataa gagtttggga ttcctgtctt 3572521 gcttctttta aaagaacgcg ctgctcttca atcagctgct gcgcttcttt atttttttct 3572581 tcagcagacg taatttctcc agcgatgtgg tcttcacgct gtttcattat gtttaatagc 3572641 ggccctaaag cgtatttctt cagaagcgct aataagatta acatagctaa cagttggaac 3572701 aggatatctc cgccgttaaa cgacaatcct agttcaagtg gtaattgaga catctactac 3572761 ggcaactccc ttctgcaggt ttttctttgc tgatccagca gccgcacttg tctcttttca 3572821 gccggcaagg cgggatgctt atcagacata aagcaatggc gaaggttctc ttggaatgat 3572881 cttcgccatt tttagttcat ataaggcttt tatgcttagc caaagaacgc taagaatgcg 3572941 ataacgacag cgataatagg aagggcttca actaatgcga tacccatgaa cataagagtt 3573001 ctcagttctt tacctgcttc cggctgacgg gcaatcccct ctaccgtacg tgaaacaatc 3573061 aaaccgttac caatacctgc accaagtgcg cctaaaccaa ttgcaatcgc agctgctatt 3573121 aaattcatga aaaagttcct cctttaaaat gttatccgtt tggatataat gttttaatga 3573181 tcatgactga ttttatgaga catgtacacc atcgtcagca ttgtaaagat aaatgcctgg 3573241 atagcaccaa taaataaact gaatgcttgc catgccagca tcggcagaat ggcaccgatt 3573301 gtaccgacaa gaccgagagc cacgctttgc gaataatggc ttgttgctaa tcccgcaagc 3573361 aggccgagaa gaatctcacc ggcgaagatg ttaccataca gccgcaaacc tagagtcagc 3573421 gtattcgcaa actcttcgat gattttcatc gggagcatga atggaacagg tcttaaatag 3573481 tctttggaat attccttgag ccctttcatc ttcacaccat agtagtgggt taaagcaaca 3573541 accatcacgg ctagcgttaa tgtaatggca ggatcggctg tcggagactt ccaccagagc 3573601 tcatgtccga ttgtaataga gaacggcagc cccagcatat tcgacacaaa tatgtacatc 3573661 agcaatgtga caccaagtgc caagaagtta gcccctgttt ttaaatccat tgtactgcca 3573721 ataatattgc ggacgaaatc aacaatccat tccataaagt tctgggcttt tccgggacgg 3573781 atcgaaagcg ttcttgtcgt caatatagca atcaataaaa caatcacact cgccacagta 3573841 atcatcagaa tgtttgtcag attaaaagta agacctagaa attctatagt tctgtaacca 3573901 tgattcaaag ggttttcacc tctcttccat tgatgaacgt ttaagctgga taaaggaatc 3573961 tatcataatg acagggtata ttgtcattaa tccaataact gtacttgcca tatgaaagta 3574021 ttcgggattt ttataggcaa cagccacagc aagaatcgca ttgcaccacc gcgctgcgct 3574081 cccgagagat cgtatggact ttcctttctc tacagctctg tcaaaagcat tcattcttct 3574141 gacgagcagt aaaaaattaa acaaactgaa aacagttccc agaataaggc ctaaaaaaac 3574201 ggttttatac gctgttaaac cataacccag tacatacact gccaaaatga acaataaata 3574261 tttgcgttgt ctgctaaatg taagcttggg atcgtccatc aattatctgt ctcctgatga 3574321 aaaaataatg tatagcttgg atacggcaaa aatcagcggt taacccttag tagaagacct 3574381 tttttgaccg gcaaaacggg cctgttcgaa aaaatcattc atccgcaagc cttgcaggga 3574441 tgctgtttca ttcgcttaaa taaatcctca taatacgggt ttgctgagag gatttacatt 3574501 gaggatgagg actataatga aagctatgaa aaccttctca taataccctc gtttagcata 3574561 caatagcccc taacatgtgt caatctgttt aaagttaaaa aactttttat actttacgtc 3574621 tccacagaat gttcacattt tcacctataa ttgtatacag attcaccgaa tagcaaaaaa 3574681 ctggataaaa aaatgaaacc cccttttggg gatttcattt tttattttgt tccaaacatg 3574741 cggtcacccg catctccgag acctggaaca atatatcctt tttcatttaa tttttcatct 3574801 agcgccgcaa tgtaaatatc aacgtccgaa tgatgcttct gcaattcttc cacaccctcc 3574861 ggcgctgcta caagacacat gaaacggata tttttcgcac cgcgtttttt aaggctgtga 3574921 atggcttcaa ctgcggaacc gcctgtagcg agcatcgggt caaccacgat gaattcacgc 3574981 tcttccacat cagaaggaag cttgacatag tattccacgg gttttaaggt ttctggatca 3575041 cggtaaaggc cgacatgtcc cacttttgcc gcaggaatca gctttaaaat gccgtcaacc 3575101 attcccaatc ctgctctgag gataggaacc actccgagtt ttttccctga gatgactttc 3575161 gatttcgcag cctgaaccgg tgtattgata tccacttctt ccagaggaag atcgcgggta 3575221 atttcaaatg ccatgagtgt agccacttca tctactaact ctctaaaatc cttcgtacct 3575281 gtattttcat tccgtatata tgtcagcttg tgctgaatta aaggatgatc aaatacataa 3575341 acctttccca tactgtgttt cagctccttt tttattgtcc catcaacaat tacacacttc 3575401 tattgattct acaaaaaaag acattgagtt tcaagaacat cgtcaaaaaa cccgccgggc 3575461 ataagcccaa gcgggtttta ggatcttaat aatctaattc tttatataaa ggaaatttat 3575521 cagtcagagc agctacacgc tgtcttgctt cttcaagttt tccttcatct tcgtggtttt 3575581 tcaatgcaag cgcaatgata gcaccgactt cttctaatgc gtctccgtca aaaccgcggc 3575641 tggttacagc agctgtacca agacggatgc cgcttgttac gaaaggtttt tcaggatcat 3575701 atggaatcgc gtttttgtta gacgtaatac caatttcatc aagtacatgc tccgcaacct 3575761 taccagtcag tccgagcgaa cgaaggtcaa caaggataag gtggttgtct gttccgcctg 3575821 aaacgagctg gatgccctct ttcgttaagg cttcagccag acgtttcgcg tttgaaatga 3575881 cgttttgtgc atatgttttg aaatcgtcct gcaatacttc accgaatgaa acagcttttg 3575941 cggcaataac gtgcatcaga gggccgcctt gaattccagg gaagatcgat ttatcaattt 3576001 tcttgccaaa ctcttcacgg caaaggatca taccgccgcg aggaccgcga agtgttttat 3576061 gtgttgttgt tgtaacgaaa tcagcgtaag gaaccgggtt tggatgaagg cctgccgcaa 3576121 caagtcctgc gatatgtgcc atatccacca tgaagtaagc gccgacttca tcagcaattt 3576181 cacggaattt cttaaagtcg attgtacgag gatacgcact tgctcctgct acgataagct 3576241 tcggtttatg agcgagggct ttttcacgca cgtcatcgta atcaatatat tgagtttctt 3576301 tatctacgcc gtactcaaca aagttatatt gaacaccgct gaagttgact gggcttccgt 3576361 gtgttaaatg gccgccgtgg gagaggttca tcccaagtac agtatcgcct tgctccaaaa 3576421 tcgtgaagta cactgccatg tttgcttgtg cgcctgaatg aggctgaacg tttacatgct 3576481 ccgctccaaa gatttccttc gcgcggtcac gggcgatatc ttcaacgaca tcgacgtgct 3576541 cgcatccgcc gtagtagcgt ttgcccggat atccttctgc gtacttattt gtcaaaacag 3576601 atccttgtgc ttccataacc gcttcactta caaagttctc agaagcaatc aattcgatct 3576661 tagtctgttg gcgttcacgc tcatttttaa tggcgttaaa cacttgttcg tcttgcgcag 3576721 gtaaatgttt catcagcgag atcctctcct atccgtatcc tgttctttgt ttttaccatc 3576781 actattgtac atggttttta aggccgatgt aaaagattat ttttaaaaaa tctaaatttt 3576841 tattggtaaa aacgaatatt aataacttaa atttaattta aagttcggaa tttatttcac 3576901 tatcttaaaa taaaagaaaa gactggctat gcagtccttt cattcgcact cataaaccgc 3576961 ccgcactccg ccgattagtt tcggccgtgt acgcgccaat gtcacatgag ctgaaccgag 3577021 gctgttttga gagacacgca cagggacagc caccggtttc agatgcatgc cgataaacgt 3577081 atcgcctata tcaattccgg cgtcagcctg aatggtttca acaagaacag gagacttcat 3577141 ctgcttaaac gcataagacg ccatcgctcc gcccgctttt ggaacgggca cggcagaaac 3577201 ggttggaagc ctgaacagct tggctgtttc tgcttcgacg acaagcgctc tgtttaaatg 3577261 ctcgcagcat tgaaacgcca gatggattcc cgttttttcc cggagctcag caagtccgct 3577321 gtagatgctt tcagcgatat ctacactgcc cgatgtgccg atccggctgc cggccacttc 3577381 gctcgtgctg catccaagga cgaagagctg atcttgtttc aattccgctt ggtcctgaaa 3577441 ctcagacagc atcgtcttcc acgtttgttt caactcattc attaaacagc acccctacag 3577501 gtttttctct tcataatcgg agatttttcc aatacgcgtt tggtgtcttc ccccggtaaa 3577561 ctcagtagtc agccagattt ttgcgatttc ccgagccaaa ccaggtccga tcacccgttc 3577621 acccatcgca aggatgtttg tgtcattatg ctccctcgtc gccttcgcgc tgaaggtatc 3577681 gtgcgccagc gcgcagcgaa tcccttttac tttattagcg gaaatgctca tgccgatgcc 3577741 tgtcccgcaa attaaaatgc ctctgtcaac ttcgccgcta accacttttt cggccaccgg 3577801 aaaagcataa tccggataat cgacagagcc gctgccgcag tcacagccca tatcaatata 3577861 ttcaatttgc aattcgtcca ttaactcttt gatttcattt cgaatgtgaa cgccgccatg 3577921 atccgatgca atggctactt tcatctgctt ttcctcccag cgtgtgtgat gcggcccgcc 3577981 cgctttattg accgcgcagc ctgtccgctc tttgattcac accatatgat gtgcttttca 3578041 ctatattcta ctccttcacg caggatttgc aaatgacctg tttgcagatt ttctgacaac 3578101 ttatctacgg tcttttttca gctgttttgc cagctgccga agaagctctt caagctcatc 3578161 tcgcgtttgt ttatagatgt caattgagcc gccgaacgga tcgaggacat caccatggct 3578221 gcctgtgaca tattctttta acgtaaacac tttatcacga taacgtccaa attggctggc 3578281 aatgatctgt ttgtgctgat gggtcatagc cagaaccaaa tcagccgatt ccataagttc 3578341 ttcagttaat ggagaagaca catgattaag ggcaatgtgt ttttcaaaca gcgcttcgac 3578401 tgcatgaggc gtcgctttcc cattaggtga agcaaacacg cctgccgagc ggacattgac 3578461 attcagccct tccctttctg caattgattt aaaaagcgcc tcagccattg ggctgcggca 3578521 cgtatttcca gtacagacaa aaataatatc catgtcagtc accccttatt tttctctatt 3578581 atatatgaag aaaaaagaaa cggcgacttc gtttctttta ttggtatatt aaattggcaa 3578641 aagcagcttt aatccaaaca cgattaatat gatgcccccg agcgcttcgc tgtatgtgcc 3578701 aagccatgac tgcacttgtt ttccgaccag caggcccagc catgtcaaca tcatgctgaa 3578761 cagcccgaac agggtaattg tgaggagcgg atgcgagccg tatatcccca agctcaagcc 3578821 gacggaaaag ctgtcaaggc tgacgccgat ggcaaacagc aataagcccg gccctgccgg 3578881 tgacatgaat cgttcttctg actgtttaaa agaggccata agcatttgaa ccccaagaac 3578941 aaaaagcagc gccccaccga tataaaccgc taacacgccg aggagccctg acagcatgtt 3579001 accggccgcc atccctgcga gaggcatgat gacgtgaaag aggccgatga tgaaaccaat 3579061 atagaatatc tgcttctttc taagtttgac catgcccatt ccaaggccga cagaaaaagc 3579121 atccatccct aaagcaaacg ccatgatgct taatgtaatc agttcgccta taaacaaatc 3579181 cgacatacat aaataacccc cttggacacg ccccgctttt ttagcctatg cgtgtccaaa 3579241 aagggttaga acatctgact gctttcagcg aatcactctt cctccggcgg ctttcatcag 3579301 cctgttcata atagcaagac cgacacctgt atccggaaag gattccgcta taatgaaatc 3579361 caccttattc tcatcaaagc tgcgcaaagc atcatacagc cctgccgcaa cagtctcaag 3579421 ctgagcccgt cttccgcagc tcttcacata atcagcggaa taaacgcccg ctttttcttc 3579481 tgtcgtcagg acaccgaccc gtcttccacc ctgttgatat tcttgaatga ggtgctgaat 3579541 gcgctctggg ctgccttcgc aaatggcaag aggcgctgtc ggcgcataat gtgtatattt 3579601 catccctgga gaaatcggct tctcgttttg gtcgctgagc cctttatcca catggatcgg 3579661 cccgatcacc gcttcaattt gttccttcgt aatgccgcca ggacgcaaga gaacagggat 3579721 gtcgtccgca catgaaagca cagttgattc gaccccgatt ccggtagggc ctccatccac 3579781 aataccggct atgcggccat ccaagtcgtg agccacatgc tccgcttttg tgggacttgg 3579841 cttgcctgat agattggcgc tcggtgctgc aatcggcagt cccgattcgc gaatcaatgc 3579901 aagggcaagc ggatgatccg gcattctaat ggcaaccgtt tcaagacctg ccgttacacg 3579961 aggtgaaagc gcatcaggtt tgcaaggcag aatgagcgta agtgctcccg gccaaaaccg 3580021 tttcatcaat gttttcgcct tttccggcgc cgggcccgtt aaatcctcaa gctggctgat 3580081 atccgcaatg tggacaatca ggggattatc gctcggccgc cctttcgcct catatatttt 3580141 tttgacggca tccgtatttt ttgcgtttgc gcctaggcca tatactgttt ctgtcggaaa 3580201 ggcaacgacc tcattttctc ggagcaaagc ggctgcttgt gcaatttgtg gatcatttgt 3580261 ggataactcg tcagttacat ccacaaacca tcttttcgtt ttcatttctg accaaactcc 3580321 ttattcacaa caataaaacg attgttttac gcgtgtaatc cttttgaaag tataaaagat 3580381 gtcctgtaat aaaacaagcg ttatccacaa attgtggaca acgctaataa agaagtggat 3580441 aagtatgtgt ataaactgca cttatccaga cgcttttttc atcaaaacgg ctccttctgt 3580501 ttgccgcgat tcacagaagt gatcagaaga aaacagctcc tccggtacac tctcagctct 3580561 ttcaaaaccc atggccgtca gaaagtccgc agaggaatgc tgatttgcta ctaggtacac 3580621 ggttttgatc tgatgctttt cgcacagcac ctccatgctt tgaaaaagcg tgacgatgtg 3580681 gccttggtga agcttgtccg atatgacaag tgatcgcagc agcccctggt cacagcttat 3580741 tttttcaata ccgaggcatc cggcaatgtt tttctcactg tcctccagca taagaaattg 3580801 agtgaagcct tctttcacgc cttcatagct ggtttttgcc tgttttaaaa atgcctcgag 3580861 cacatctccg tctttttccc ttgccacccg cagttgataa aacatccgtt caccccgttt 3580921 ttgcgttctt tcttccaatc tatgaggcaa atctattttt agaccagatg attaggaaaa 3580981 aaggtcggaa atccattcga ctaaaaagaa tttcacttct gtgccgtctt ctttttcttc 3581041 gttctcttct tttttggctt tttccgcttt agcggttacg tcctcaagca ctttttcagt 3581101 ctgctttttt gaggcttctt tatcttcttg ttctttgacg gcttccccgt tagaaaaatc 3581161 aagaaagcag aggggcggga acagcacaca ccaccagttg gcgccgtctc cgtttccaag 3581221 cgtaatcaaa atcgcttcat actcaccagc gggatatacc atgttgccgt aaagctttgt 3581281 cggaaacgag attttgtcaa aatcaacgga tatcgactga ttcgctcctt ctttctccat 3581341 tgtttccttt gcaattgctt tgatttcagg cagctttgaa cgaatcacgc gacgcgcttc 3581401 ttcaatagaa gtaatatcct ttacccaagt tgtgatttct ttattcaccg cgtctcttat 3581461 atgacgtttt aattgctggt cttgatcact atcgctgttt gccagtattc tcaaacgaat 3581521 cgcctgatca ggtatgacca ccggctgatt ttccgatttt tgtgccgtct cttcttttgc 3581581 cagccctacg agcgctccgg ataataaaag aaagatatat atacaaatga ttactgtttt 3581641 tttcatcggt ccccaccgtt cctctccgtg ctttgtttct agccctatta tggacaagga 3581701 gagcctggga taaacgtgca gggtgaaaaa aatctagcaa gctgttaatc ttatttatgg 3581761 tacgatagtg ttttaggagg tttaagatga aatacaatta tacagtgctg ttatcagcat 3581821 tcacgatgtc cgttctttat tcagtaattt atattcattc atttatcatt gccgctctca 3581881 tcacaatggc attttatttt ctgtttcctt atttgatctt cgcactgccg cttcaaatca 3581941 tgatgaataa aaagccgaaa cgtttcagcc ctttgtatct gctgtattac cttgccgctg 3582001 cttttattgc caacgcgatc attttcggca tgcttcagcc ttcgggacaa tctctgtttc 3582061 aaaatacagc cttttatctt ttcgctgtat taacagctct tatctattgg atatgggatt 3582121 ctgttttact gcaaaaaaag gaagcctaag aggcttcctt ttttattaaa acaaaatcgt 3582181 cagtaaataa catagaatgg aaggtatcgc cgcaacaaag aaagcggccg ccattttcat 3582241 gcgagatgta cggccttctt tggtttctga atggtagttt gcccgctgat cgcttccgct 3582301 tacagccaaa cccgatgtaa tgatcgcgag ccccactaaa acgagagacg caacgccaaa 3582361 aatcgcttca tatgaaagag cctgcggaaa aatggtgcca atcatgctct caatcgcaat 3582421 gagcaggatt cctgctgtca gggccttttt catgtttaca tcccctttgc tggtgttaaa 3582481 cagcttgatc cattcactcg ccagcaagct gcttatttat ttttatgaat cagagcgcat 3582541 atggttctgt cttttccatt aatatctttc agcacttcca cttccgcccc cttaaacgcc 3582601 ttgaggatca ggtctttgac cgccgctccc tgtttccagc cgatttcaaa aacgacaaat 3582661 actttatcct tcataacaag cggaatgtct tccataaacc gcttataaaa tttcagcccg 3582721 tctccgccat cggtgagtgc gtgcagcggc tcatgaaaac ggacaatttc cgataaatca 3582781 gccatttctt cctctgaaat atatggcggg tttgagacaa tgatatccgc tttttttccc 3582841 gccttaataa aaggctcaag cagatcgccc tgataaaagc gcacattcgc tccgagtttt 3582901 tctgcattgg cagaggcgac ttgcagcgcc tctttcgaaa tatcgaccgc cgacacagaa 3582961 aagctttggt tttcaagcgc aagcgtgacg gctattgcgc cgctccctgt accaacgtca 3583021 acaacttcga gcttgccgtc ttcagaaaaa acactccgat atttttcaag caaatgaaag 3583081 acaacttctt cagtttccgg ccgcgggatc agcacatcat cattcaccat aaattcccgt 3583141 ccataaaaaa actcttttcc tataatgtat tgaaccggca cgccctcttt atgcatctca 3583201 acgtgacgct taaagcgata cagttcgtct tcaccaatcg gttcctgtaa gcttgcgagc 3583261 agcttgcttc tctccattcc ggtatcataa agcaatagga gctcggccgc attttcttct 3583321 cttcccgctt cggttaaata agaagaagcc catttcaggg cttcgaatat cgtcttcatc 3583381 ttaaccttcc gactgctgaa gcttgcttgc ctgatcttca acaatcagcg cttcaaccac 3583441 ttcgtcaagt tttccttcaa gaatctgatc aagcttttga atcgtcaaac cgattctgtg 3583501 atccgtcaca cggttttgcg ggaagttgta tgtgcggata cgttcagagc ggtcaccaga 3583561 tccgactgct gatttccgtg tttgatcata ttcagcctgg gcttcctgct gaaatttatc 3583621 atagattctg gcacggagaa ccttcattgc tttttctttg ttcttaattt gagatttttc 3583681 atcctggcat gatacaacaa cacctgtcgg caagtgagtc agacgaaccg cagacattgt 3583741 tgtgttaacg ctttgtccgc ccggtccgct tgaagcaaat gtatcgacac ggatatcctt 3583801 ctcatggatg tcgacctcta cctcttctgc ctcaggaaga catgccactg ttgcagtgga 3583861 tgtatggatg cgtccgcctg attctgtttc cggaacacgc tgtacgcggt gggcgccgtt 3583921 ttcatatttg agtttagaat acgcgccgct tcctgtaatc ataaagatga tctctttgta 3583981 gccgcccgtt ccggttacat tcgcttccat gacctctgtt ttccagccct gaagctcagc 3584041 ataacgggaa tacattctgt acagattgcc cgcgaataaa gcggcttcct cgcctcccgc 3584101 agccccgcgg atctccatga taacgttttt gtcgtcatta ggatctttcg ggatcaggag 3584161 caccttcagc cgttctgaca gtgtttccgt ttccttctga agttcagaaa tctcttcctt 3584221 caccatgtcg cgcatctcag catccagctt ctcttcaagc atcgcttttg catcagccag 3584281 ctgttctgac gcatctctgt attgtctata tacgtcaact gtttcttgta tatcagattg 3584341 ctcttttgaa tattctctta gctttttcgg atcgttgact acttctggat cgctcaaaag 3584401 ctcatttaat ttctcgtatc gttcttcaat tgattttaaa cggtctaaca cggtcttcac 3584461 ctctgttttc ctgtgcgtaa cattctcatt atagtatagt gattaacccc agtcaaaagc 3584521 atttcaatcc cagctggaaa agctccctct gctatactgg aattcgagga gggatgatgt 3584581 tgctgaaatc catacatcat attgcaatca tatgttcaga ttacgaaaag tcgaaagctt 3584641 tctacgtaca taagcttggt tttcaggtga ttcaagaaac gtaccgcgaa gagcgcggct 3584701 cctataagct tgatttgtcg cttaacggct cgtatgtcat tgagctgttc tcgtttcccg 3584761 atccgcccga acgacaaacc cggcctgaag ccgcaggcct gcgccacctc gcctttacag 3584821 tcggcagctt ggataaagct gttcaagagc ttcatgaaaa aggaatcgaa acagagccaa 3584881 tcagaacaga tccgctgacc ggcaagcgtt tcaccttctt ttttgatcct gaccagcttc 3584941 cattagaact gtatgaacaa taacagtttt tgaagaaaaa aaggagatac ccactttctt 3585001 tgccgaatct tttcttgttt tgtctaacgg gaagggaacc gcattctatg gtcgaatacc 3585061 tagcttaaaa ggaggtatgg gatcatgaat acaaatatgg tagcaagtga actcggcgtc 3585121 tccgcaaaga cggtgcagcg gtgggtgaag cagctgaatc ttccggccga acgcaatgag 3585181 ctcggacact attcgttcac ggcagaagac gtgaaggttc taaaatccgt tcaaaaacaa 3585241 atctctgaag gcacggcgat tcaggatatt catctgccga aaagcgctaa aaagcgcaca 3585301 ggcttccttg tccaaaaaac aagtagcgac acagaacgaa gaatcgagca gcttgaacaa 3585361 aagctggaca cccttttaca gcaaaggcag gacgaaagcg aattgatggc aaggatgtcg 3585421 gaactggaac gccagctgaa acaaaaagcc gatgaaggtg tatcttacca gctgcttcag 3585481 caccgcagag aaatcgatga tattcttgca gatctgcaat cactgacctc acaaatgaaa 3585541 gaattcaccg ctcattcgat ccccgagact gctgctgctt ctgaaaaaac caaaacaaga 3585601 aaaaaaccgc tgctgtcact gttcaaattt caaacctaaa gcaaaaagct cccttaaagg 3585661 gagctttttt tgttacgcag taagcgcgat aatgattgga agtgaaatca atgacagaat 3585721 cgcactgacc acaaacgcag ttgcagtttc ttcttcttgt ttctcgaaac gagtcgcaat 3585781 catggctgca acggcagaac cagggaatgc aacaagaagg attgcttttg ttgtttggtc 3585841 agctggaagt ccgatagcaa gagcaatcag gaacattaac gcaggctgaa ccgcaacttt 3585901 tagtaacgca ataccgatag ccggcatact gagtttaatt ttacgaatac caacggtaac 3585961 accaacagcg aagagagcaa caccagatgt tgtgcttcca agctgatcaa gcattttaac 3586021 acccagctca ggaagagtga aattgaaaac cagcaccaag atcatactga ttaacggagc 3586081 agctgcaagc ggctcacaaa gaccatgcag gattgatttt cctgtcatct tccagaagct 3586141 gtcgccactc tcttcgtttt tcttagaaga ctcaccaaca gtagcgataa tgatcgcgag 3586201 cggatcaaga atcgcgttaa ccacgatacc tgtgaccgcg atcggaatcg caacttcatt 3586261 cgctccgaat aagcttccca ataccgggat acccataaat gcgaatgtcg gctgtgcaga 3586321 gttcaaagaa aatacagatg agttcgttaa atcatacttg aatataaatc tgcaaaccaa 3586381 aagaatgatg atatagaaac caacaatccc aataattaaa gaaatcatta aaggtacttg 3586441 tgataaaaat tcacttctgg aagttgtcaa aataccagcg ataaagtgag ctggaagtgc 3586501 gtatttcgtt actaacgtac ttaccccttt tgccgacttg gcatcataac ttccaaaatg 3586561 tcctgcaaac caacccagca cgataacaaa gaagatcggc gccaggagga ttaagatatc 3586621 taagatgctc aaaatattct cctccaaatc ctatgtccgt atactttagc tttacaaaaa 3586681 gctttccctc ggacagaaaa atttactcgc taattatttc gcgatgactt ttttgtattc 3586741 aggtgtccac attgcatcaa gtaccgcttg tttcacatct tcaggctgac gatttgccac 3586801 gccgtcttta attgctgctt cagcaacggc aatcgcaact tggatagaaa cctcttgaag 3586861 cttatcaatg cttggaagca atcctgctcc aggtgtttca agatcaacca tttcagcaat 3586921 cgcatcagca gttgcagcaa acatagcagg tgtaatgata cgcgcttcag ctacaattga 3586981 accaagtcca agaccaggga acgcgaatgc gttgttagat tgtccgattt cataagaaac 3587041 accgttgtat tctacattgt caaatgggct tcctgttgca ataagcactt ttccgtcagt 3587101 ccatttgaac agatcttcag gaacagcttc agcaaggtga gtcgggttag acatcggcat 3587161 gataaccgga cggtctacgt gagatgccat ttcttttaca atttcctctg tgaatgcacc 3587221 tgaaacccct gaagtaccaa tcaagattgt tggtttcgct tgacgaacaa cttcatcgaa 3587281 tggaatttga cctttttcat cgcgcttcca gtctttcact tcatccgcat tgcgaaggta 3587341 aggtttttgg aaatcaagga tgccttcgat gtcttcagtc agcaagcctc tgtaatcaag 3587401 tgtgtagaaa cgtttgttag cttcttcttc agataatccg gctagcacca ttgtgtcacg 3587461 gatttggtca gcaataccga taccagcaga accagcaccg aagataacaa cacgctgatc 3587521 tttaatagaa gcgccggttt tcttcatagc ggcaagcaca cctgcaagtg taatcgcgcc 3587581 agtaccttga atatcatcat taaatgtcag gatttcatga ttgtattttt tcatgatgtt 3587641 gcgtgcattt ttgttgccaa ggtcttccca gtgaagaagc gctttaggga agaatttcaa 3587701 tgcagctttt acataagcgt caatgaaagc ttcgtagcgt tcaccttgaa cacgttcatg 3587761 cttgttacca atatataaag gatcgtttag aagtttttcg ttgttcgtac cgacatcaag 3587821 cacaaccggg ataacacggc tagggtcaat accagctgca gcagtgtaga cagccaattt 3587881 accgattgca atattaatac cgcctacacc ccagtcaccg ataccgagaa tgctttcgga 3587941 gtcagtagca acgataagat caatatcgcc tgctgtcgca tgaaggtttt caaacgcttt 3588001 ttcaataccg tcaatgttat cgattgacaa gtagattcct tgaggtcttc tatattcatg 3588061 gctgtattcc tgaatcgctt caccaactgt tggcgtgtac acaacaggaa gcatttcgcg 3588121 aagatggttt ttcagcaatt tatagaaaag aacttcgtta cggtttgcaa gatcacttaa 3588181 gtaaacattt tgacgaaggc ggtcaggctg cgcttggaat tgctcgtacg cgcgttgtgc 3588241 ttgttgatca agagaaagta cagttggcgg cagaagccct tctaagccga gttcttgtct 3588301 ttcttctagt gaaaaagcaa cgcctttatt taaagtagga atagataaaa cttcttttcc 3588361 tctaagagtt gtttctaagt ggccttcttt cgtttttttt atgttattca agcaaatctc 3588421 cttctttctt gaaatagtta accaagttaa gtaataaccc atctaaaata tgaccgatca 3588481 tgatctttat gcgactttgt gacaattatt cgaacaatgt ctcaaaacta tttacattac 3588541 gtaagctatt gtatgcctgt caaaatcaaa attcaagaga agaaaattac ttaatttttt 3588601 aatatactta tttaaatttt ttaattgaat attatcagaa tataaaaaaa acaccggtgt 3588661 ttttagccgg tgcattctat ctttataccc atgttttgga ctatttttta gatttacctg 3588721 ggacttcgtg atgatgtctg catcttgctt catatgattc agctgcacca accaaaatga 3588781 ccggatcatc gtaagaagca ggtttgccgt caatgaggcg ctgtgttctg ctcgccggtg 3588841 atccgcaaac agaacagacg gcttgcagct ttgtcacact ttccgcaatc gccatgatat 3588901 tcgggacgac accgaacggc tctcccctaa aatccatatc aaggcctgct gctatcacac 3588961 ggtagccttt atcggcaaga gatgataaaa cctcaacaat ttcctgatca aaaaactgca 3589021 cttcatcaac cgcaaccaca tctgtacttt cactgatgtg atcccaaatg tccgcagcag 3589081 acgaaatggc atagctcgtc atcgatgttc cattatggga gacaacagca gcttcgctgt 3589141 atcggttatc aattacaggc ttaaataccc tgacttcctg cttggcataa gttgctctct 3589201 tcactcttct gatcagctct tcagatttcc ccgagaacat gctgccgcaa atcagctcaa 3589261 gccacccgct ttgtttcatt atgtacatag gcttcgctcc cctctctctg ccagctgtgt 3589321 tttagacaat ataaaaaaca ggcaagactg ctgcttgcct gttgagaaat ctattattac 3589381 ttaagaccgt attttttgtt aaagcgatca acacgaccat cagcagaagc gaatttttga 3589441 cggccagtgt agaatgggtg gcattcagag caaatctcaa cgcgtacctc ttcttttact 3589501 gagcctgttt caaattcatt tccgcaagcg catttaactg ttgctttttt gaaattagga 3589561 tgaattcctg ctttcattgt atccatctcc ttccgccctg aatcccgtgt ggaaacagag 3589621 ttattatttc ggagcattgt ccgaaacgca tatgagaaaa ttatatcagt gatttacttc 3589681 ttttgcaaat acaatttacc ttcttgcaga tgatagattt gcctgtttcc attcttgatt 3589741 gagaatatcg aaaaattcct ggtttgtttt ggtttttttc atttttctca tgaacttttc 3589801 tgcgaaatca ggtgaatcag acatcgtttt gcggatagac cataaacgat caagatgctc 3589861 tttaggcaca agcagctctt ctttgcgcgt tcctgaacgg cggatatcga tggcagggaa 3589921 gatgcggcgc tcggcaagag agcggtcaag atggagctcc atgttgcctg ttcccttgaa 3589981 ttcttcataa atgacatcat ccatacgtga acctgtatcg accagagccg tagcaaggat 3590041 ggttaagctg ccgccctctt cgatatttct cgcagcccca aagaagcgtt tcggacggtg 3590101 gaacgccgct gggtcaatcc ccccggaaag cgttcttcca cttggcggaa tcactaagtt 3590161 gtaggcgcgg gcaagacgtg tgatgctgtc catcaggata atgacgtctt ttttgtgttc 3590221 cacgagacgc atcgcacgtt caagcacaag ctcggccact ttgatatggt tttccggcac 3590281 ttcatcaaac gttgagctga cgacatcccc agctacagag cgctcgatat cggttacttc 3590341 ctcaggtctt tcgtcaatta aaagcacgat cagctctgct tcaggctggt tcgctgtaat 3590401 gctgttggca atttccttca gcaacatcgt ttttccggct ttcggcggcg caacaatcaa 3590461 tccgcgctgc ccaaatccaa ccggcgccat catgtccata attcttgtag acaagaagtt 3590521 cggctttgtt tcaagcacca tttgacgatc cggataaagt ggcgtaagag ccgggaaatg 3590581 cacacgctct tttgcagatt cgggatcatc cccatttact gcttcaacgt gcaaaagtcc 3590641 atagtaacgc tcattttctt ttggcgggcg aaccttgcca gatactttgt ctccgttccg 3590701 caaatcgaaa cggcggattt gtgaagctga gatgtaaatg tcttctgagc ttggagagta 3590761 gttgatcggt ctcaggaatc cgaaaccttc agactggatg atctcgagaa cgccttccat 3590821 aaacagcaga tcttcctgtt ctgcattcgc tttcagaatg gcgaaaatga gttctttttt 3590881 tgtcagtttg ctgtaatagg agattttata atgtcttgca agttcataaa gctctttcaa 3590941 tttcatattt tccaaagagg aaatagatac gtctttcata aaaacaccac gcttttcata 3591001 gtcaatatct tactctgaac atgtcatctg ctgcttttgc acaacatccg ccaaagcaca 3591061 ttcttttttt aacataaagg aacttctatc ggtaacactt ccacccatga tcggcgcttt 3591121 tgttaaaagg attgtcttaa tgagttttga aggaagcgag gacaaaaaca tgagaagatc 3591181 aatacttata tcgtctgtat gcggtagaaa ttgaaacttt cctagtgctt aaaagaaggt 3591241 attacgcagt aaaattcgca gcactcttta tttttacctt atttcaaaaa attattcaac 3591301 tgaaataagg ttttgacacg gaattgatag agttgacgct tttctgcaaa agttaaagcg 3591361 ggctcacacc cgctttttct gtttgttatg gacggattac aagatttggt ttctttttca 3591421 agctgtgtct gccgtcaacg aaacgaacag tgcccgattt tgcacggata actaagcttt 3591481 cagttgtacc gacagagcct ttgaattgaa ctccttttaa cagctcgccg tcagtaaccc 3591541 ctgtagctgc aaaaatcgcg tcatcaccct tcacaaggtc ttccatgcga agcactttgc 3591601 ttaaatcaag gcccattttg tgacagcgag tgatttcttc ttcgctttgc ggaagaagtt 3591661 taccaatgat ttctccgccg agtgctttta gcgcaacagc ggaaagcaca ccctcaggag 3591721 cgccgcctga tccgaacagg atatcaacgc ccgtgtggtc gaaagccgtg ttgatggcgc 3591781 ctgcgacatc gccgtcattg atcaatttga ttctggcgcc ggcctcacga agctcggaaa 3591841 tgatttttgc gtgtctttca cggtttaaaa ttgtggcaac gacgtcctca acgtccttgt 3591901 ttttcgcttt tgccaccgct ttaaggttgt caatgacagg tgcttcgatg tcaatgcagc 3591961 ccaccgcttc cggaccgact gcgatttttt gcatatacat gtcaggagca ttcagaagcg 3592021 tgccatggtc tgcgaccgcg ataaccgtca gcgcgttcca gccgccgctt gctaagatgt 3592081 ttgtgccttc aagagggtca actgcgacat caacgcgagg gccgtacccg tttccgagtt 3592141 tttccccgat atacagcatt ggcgcttcgt ccatttcccc ttcaccgatt acaacggtcc 3592201 ctttcatcgg cactgtatca aaaacgtctc tcattgcact tgttgccgct tcatcagcct 3592261 catctttttt tccccggccc atccatcttg ctgatgccaa tgccgcagct tctgtcacac 3592321 gtaccaattc cattgataaa cttctttcca tttcaacacg atctcctctc acaagaaacc 3592381 attatgaatt ttgaagctgt tctatttctt cgtcagtcat tctttcacgc caaattgtcg 3592441 ctccaagccc ctcaagcttc ttctcaaggc tgctgtatcc tcggtcaata tgctccagtc 3592501 ccgtaatttc cgtgacgcca tcagccatca gtccggctac caccaagcag gctccggcac 3592561 gcagatcact cgccttcact tttgcgcctt gaagctcgac aggacctgtg atgatggcag 3592621 atctgccttc tactttcata ttggcaccca ttcgtctcag ctcatcaatg tgcttgaatc 3592681 ttgccgagta gatggtgtct gtgacgacac tcgtcccttt cgcccttgtc aggagcgccg 3592741 tcatcggctg ctgtaaatca gtcggaaacc ccgggtatac gagggttttg acgtcaaccg 3592801 gctttaagtt cttctgcccg ccgacaatga ggagctggtc gtcgcttgtt tcgatatgat 3592861 agcccatttc tctcagcttt gccgttaacg actcaagatg agtagggatg acgttatcga 3592921 taatgacttc cttgcccatt gcagcccctg caatcataaa tgtcccggct tcaattctgt 3592981 ccggaatgat cgtatgcttg cagccgtgca gttccttcac gccgtcgatt cgaatcacat 3593041 tggtgcccgc acctttgatt ttggcgccca tgctggtaag caatgtcgcg acgtcaatga 3593101 tctcaggctc cttggcagcg ttttcgatga tcgttttccc ttctgccaaa acagcggcga 3593161 gcataatgtt aatcgttgcc ccaacgctta cgacatctaa ataaatccgt gcgcctctca 3593221 gcctttcagc tcgcaaataa atggcgcctt gttcattggt tacttcagct ccgagtgctt 3593281 caaagccttt gatatgctga tcaatcggac ggggccctaa gtgacagccg ccaggcaatc 3593341 caatgaccgc ctgcttgaag cggccgagca tcgcccccat taaataatat gacgcgcgaa 3593401 gcttttttac tttcccgtta ggaagcggca tgctgatcat cgacgtaggg tcaacaacca 3593461 tttccccatt ctcaaaatgc acgttgccgc cgatttcctt taacaggtca cgcagcgttt 3593521 caatatctga aatctctgga agcccttcaa ttgtcacctc ggaatttgcc aaaatggttg 3593581 caggtattaa cgcaacagcg ctgtttttag cgccgctgat atgtactgta ccgtttaacg 3593641 agtcaccgcc ggcaatattc aacttttcca tgatagtctc cttccataag aagatagctg 3593701 cggagctaaa taaaatgtca ttttattctg tctctgcaaa taaagctcat gtccaaaatc 3593761 tagccaattc gaagagaaag aatacaacac attgtaaaat atcaggaaga aaatagcgaa 3593821 gctttggggg gtacaggttt caaaagatgc acagagaccc gccggctcga gagacatcgt 3593881 cgtcatccgg caaaagcagt acgcataccc ttcattccga tatcagcttc tgcagcccaa 3593941 tgattccttc tctgtaaagc ggcgtcagca tctgaagatc cgctgtatca ggtcggtgaa 3594001 atacaaaggc cgcggcaaac aggcataaag ctgtttgccg cccctttcat tatttgttcc 3594061 agtctgccag gaattgttcg attcctttgt ctgttaacgg gtgtttagtg agcgcatgaa 3594121 tgactttcag cggcattgtg ccgatatgag cccctctaag agcagcttct gtcacgtgct 3594181 gcggatggcg gattgacgct gcaatgattt gcgtgtcaag gccgtgaatg tcaaaaatct 3594241 gtttaacttc tgaaatcagg tcaagcccgt tgtggccgat gtcatctaaa cgtcccagga 3594301 atggagatac atatgttgcc cccgctctgg cagcaagaag cgcctggttg gcattgaaga 3594361 tcaatgtaac gtttgttttg atgcctaagt cagtaagtgc tcttaccgct tttaaaccgt 3594421 cagacgtcat tgggattttc accgtaatgt tcggagcgat cttcgccagt tcttttcctt 3594481 cctcgatcat ttcctcagct ttcaaagaaa taacctctgc gcttacagac cctttcacga 3594541 cgtctgtgat ctcgcgaaga cggtcgtgga atgatacgtt agcttccttt gctactaaac 3594601 taggattcgt cgttacaccg gcgagaattc ctaattcatt cgcttctcta atttcatcga 3594661 tattggctgt atcaacaaag aataacattt tcaaaaagcc tccctgatta agaaattttc 3594721 tgaactgcga atatgattgc gctttctaaa gatagacgga aaaccgcctg tcaagctgtc 3594781 aggcggctat aaaaagttcc aattgaatta agcttggttt gaagaaccaa attcacgcat 3594841 tttaccgata actgtttctt tgatcgcttc acgagctggt ccaaggtatt tacgtggatc 3594901 gtactcgtca ggcttagctg ccaatgtttc gcgaacagct tttgcagaag aaatttggtt 3594961 ttcagtattc acgttgattt tagctgtacc aagtgaaatt gattttttga tgtcagcagt 3595021 cggaattcca gtaccgccgt gaagaactag cggaaggcca gttgattttc cgatctcttc 3595081 catttctttg aagccaaggt ttggctcacc tttgtaaggg ccgtgaacag aacctaatgc 3595141 aggtgcaagg cagtcgatgc cagtgcgctc aacaagctct tggcactctt taggatcagc 3595201 gtagattacg ccttcagcga taacgtcatc ttcttgtccg cctactgttc caagctcagc 3595261 ttctacagat actccgtgga aatgagcaag ctcaacaact ttagcagttg ttgctacgtt 3595321 ttcttcaaat ggatggtgag aagcgtcgat cattacagat gtgaaacctg catgaatcgc 3595381 tttcgcacaa gattcaaagc ttgaaccgtg gtctaagtga atcgcaacag gaactgtcac 3595441 tttgtactct tccataagtg cttttaccat agcaacgact gttttgaagc cgcccatgta 3595501 gcgtcccgca ccttcggaaa caccaaggat cactggagat ttttcttctt cagctgcttg 3595561 taaaatcgct tgagtaaact caaggttgtt taagttaaat tgtcctacag cgtacccttt 3595621 ttctttagct gtattcaaca tttccgtcat agaaactaaa ggcatgtcga atgtcctcct 3595681 tatgtagcct gattgtcttc tagcgaaaaa agctttccac cctagcatga cccatatatt 3595741 gctgtcatat gtaaatactc agatcgcttt ttctccataa ctaggatacc aacttttcga 3595801 caaatcggca acataatgac atgattcatt tgtttcttct ttttgtcagt tagacttcag 3595861 gggcagatat tttttgacgg cgtctctgat ttcgtcgatg tcaaacggct tggcaaagtg 3595921 cgtcagagcg cccaattcct tcgattcctg gatcatgtcg agctctccgt atgccgtcat 3595981 gataatgacc cggatgtttt cgtcaatgac cttcatccgt tttaagattt cgattccgtc 3596041 catgccggga attttcatgt ccaacagcac aaggtcgggc cgttcttttg tcacaatgtc 3596101 aagcgcctgc aggccgttcg cagcctgaaa cgtctggtag ccttctttat tgaacacttc 3596161 atttagcaaa atacgaatgc cgtattgatc atcaacgatt aaaatttttt cattcatcat 3596221 tttacacccc aatattatga ttttcgtcaa aagtaagcag tattgtatgt attctgtttg 3596281 attttcctat ttcctttaat tataatagtc tactttacga cattttctga gcattttctc 3596341 ttttgttgta tactgatatt gtacgttata aaggaggatt cacttatgtt gaaaatattc 3596401 acgacgcagt taacaggtat tttttcccgc attcaggata aggaatctga cgcgattgaa 3596461 gatggggcgc ggctgcttgc tcaagcggtg atcagcgggc attccattta tttatacgga 3596521 gcgaatgagc ttcagggcgt cttttatgag gccaccgaaa gcaaagaacc cttcccatct 3596581 gtcaaagcct ttccagaaaa cgctgaggaa gtgacagaaa gcgacagggt gctgatgttt 3596641 tgctcaggga cgggcacagc cgaagaacag gagctcgcaa aagagcttta tgaaaaaggt 3596701 gcgggagtcg tatgcgtatc gcccgcagcc aaagacagtg cgggaataga acagtattgt 3596761 gatgtgcata ttgattctaa attaaaaatg ccgcttgttc ccgatgaaga cggcacccgt 3596821 tacgggtttc cctctttaat gacagcactg tatgtctatc acgctttatc gtttacacta 3596881 aaagaaattc tgcaagagta tgcataatat cttattgtac atgctggaac ttgccggaaa 3596941 caaataaaaa agacttgccc gcttttgaca aacggcaagt cttttttatt acttctgatt 3597001 tgcagcttcg acagacgctc cgataaagcc tttgaataga ggctgaggtc ttgtcggtct 3597061 tgacttgaac tctgggtgga actgagaagc cacgaaccaa gggtggtctt tcagctcgat 3597121 gatttcaaca aggcgtccat cagggcttgt gcctgagaat acgaagcctt gctcttccat 3597181 ttgctgtctg aattcattgt taaactcata gcggtggcgg tggcgctcgt acaccacttc 3597241 atcctgatac acttcaaagg ctttcgtgcc ttcttcaagc ttacaagggt aaaggccgag 3597301 acgaagcgtt cccccaagat cctcaacatc cttttgttca ggaagaagat caatgatcgg 3597361 gtattgagtt gacggatcaa tttccgctga gtgagcgcct tttaagccca atacgtttcg 3597421 tgcgtattca atagacgcca cctgcatgcc caagcaaatg cccaagaacg gaatgttgtt 3597481 ttcgcgcgcg tattttgtcg cgacgatttt cccttcaaca ccgcggtctc cgaatccgcc 3597541 cggcacaatg atgccgtctg ttccgcttgt gagttctgcg atattgtttt ctgtcacttc 3597601 ttccgcgttg atccacttca cttttacatc tgtgtcaaac gcatagcccg catggcggag 3597661 agactcgaca acagaaatgt atgcgtcagg aagctcaacg tatttgccga caaggccgat 3597721 tgtaatcgtt tgagacaggt tgctgacttt gttaacaagc tctttccact cggacatttc 3597781 cgcttctttg catgccaatt tcatgtgctc gcaaacaagc ttatcaagcc cttgtttttg 3597841 aagctccagc ggaatggagt aaaggttgtc cgcatcttca cattcaataa ccgcttttgt 3597901 atcgatgtcg cagaaaagcg cgattttatc tttcatatct tgagaaatcg gcatttctgt 3597961 acgaacgacg atgatgtttg gctgaatgcc caagctgcgc aattctttta cgctgtgctg 3598021 tgtcggtttt gtttttaatt cgccagcagc tttaatgtaa ggcacgagcg tacagtggat 3598081 gtacattacg ttttcacggc cgatgtcgct cttcatttgg cggatcgctt caaggaatgg 3598141 cagtgattcg atgtctccga cagtaccgcc gatttctgta atgacaacat ctgcgtttgt 3598201 ctctttccct gcgcggtaaa cacggtcttt caattcgttt gtgatgtgcg gaatgacctg 3598261 tacggttcct ccaaggtaat ctccgcggcg ttctttttta agaactgttg aatagatttt 3598321 acctgttgtc acgttgctga atttattcag gttaatgtcg ataaaacgct catagtgacc 3598381 aaggtccaag tctgtttcag cgccgtcatc cgttacgaat acttcaccgt gctggtacgg 3598441 gctcattgtt cccgggtcaa cgttgatgta tggatcgaat ttttgaatcg tcacgttcag 3598501 tccgcggttt ttcagcaaac gccctaatga agctgctaca ataccctttc caagtgagga 3598561 tacaactccc ccggttacaa aaatatattt cgtcatttcg tttgctcctc tcttcgctct 3598621 tagctacatt tttaaaatgt actattttat aaaaaatcat ttagcctttt aaatgattta 3598681 taagaaaaat gaggggtgaa aataagaaag ctccctttca atttcttgaa agggagcata 3598741 acgtactatg ttctctcttc gtttttgaag agcccaaaat acatactaca tagttcgact 3598801 atgaaagtca agatcgtttt gaagatgaaa tctgatacta tttaatttcc tcttcttcat 3598861 catcatagtc ttcatcatct tcatcaataa tatcttcttc gatctcaaga tcatcgtcgt 3598921 cttcatcaag atcttcttcg tcaaaatcgt cggcttcaag atcgagttct tcctcaactt 3598981 catccaaatc aaggtcgtct tcgtcgatct cttcaaactc gtcaagatca agatcttctt 3599041 cgactgcttt cttcgctttt ttctttttcg ccttgactgt cggctgagtt tcttcatcaa 3599101 gctgatcata aggataccag ctgcgaagcc cccacgtctg gtcagaaagc gccaggaagc 3599161 ggccgtcaat gtttaaatct gtataaaatt gagcaatgcg gtctccaagc tcttcttttt 3599221 tcacgccgag caaagatgcg atttcattta aaagctcctg aaaaggaact ggttttttat 3599281 gttcttcaaa taattcgtga gcgatttcaa ctaaagccat ttcctttagc tcttcctgtg 3599341 aatattgttt gatacccaag gtcggacact ccctttctat tacttatatg tatctgtttt 3599401 atcaataatg aaagcgattt tgtatcgttc ttatacaaac catacctctc attataaaca 3599461 aaataaaaca gaatatgcta cccttaacag cgttaattta aataatttta caagagtgat 3599521 ccgactgaga gatgttttcc gttaatccgc gagcattctg gagatgacca gtctttgaat 3599581 ttcttgagtg ccttcataga tttgcgtgat ttttgcatca cgcatatagc gttctaccgg 3599641 ataatctttt gtatagccgt agccgccgaa aatctgcacg gcttcggtcg ttaccttcat 3599701 cgccgtatcc ccagccatca gtttggacat ggcggaagct tttccatatg gaaggcccga 3599761 tgattctaac catgcagcct gataggtcag tagccttgaa gcttctatca ttgtcgccat 3599821 atccgcgagt ttaaaagcga tgccctgctg ctcggcgatc gattttccga attgctttcg 3599881 ctcttttgca tattgaagcg ccgcatcaag cgctccttgg gcgatgccta cagcttgtgc 3599941 agctatgccg tttctgcctc cgtcaagcgt cttcatcgcg attttgaagc cttctccttc 3600001 ttctccgaga cgctttgatg cgggcactac acaatcttcg aacatgattt ccgttgtcgg 3600061 tgaagaacgg atgcccagct tcttttcttt cttgcctgta aaaaatcctt caaaatcctt 3600121 ttctactata aaagcggtaa cgcctttttt ctttttctcg ggatcggtga cggcaaaaac 3600181 aatgtaaata tcagcaacgc cgccgtttgt gataaacact ttggaaccat ttaacacata 3600241 gtcatcgccg attcgttcag cagttgtttt catgctgccg gcgtcagagc cagaccctgc 3600301 ttcggtcaaa gcgaatgcgc cgattttctc tccgagagcc agctgtgtta agtactctgt 3600361 cttctgttcc tctgtcccaa aggcaaacag cggccagctg caaagagaga tatgggcgga 3600421 aagcgtcaca ccggtggagg cgcacacttt tgacagctct tccaccgcga tgacgtaggc 3600481 taaatagtca cttccaattc cgccgtaatc ttcaggccat ggaattcccg tcaggcccag 3600541 atttgccatt tcccgaaaca gctcgcgatc gaagcgttct tgttcgtccc gttcagccgc 3600601 tgtcggggcc acctcatgct tcgcaaaatc gcgcaccaat tttcgtatca tctcatgttc 3600661 ttctgataat gaaaaattca ttgcttctcc cccattttca gatcagcgcc taaaacggat 3600721 tgagccagaa gctcgacgac gtcgtacgtt ttgacttggt cttcggcttc cttcgccttt 3600781 gtgccgtccc caagcatcgt gagacaatac ggacagccag aactgatcac cgatgggttg 3600841 actgcgagcg cttgctctgt cctggcgacg ttaatcctgt tgcctgtttc ttcctccatc 3600901 cacattaatc ccccgccggc tccgcagcac atgccggttt cccggcttct ctccatttca 3600961 acaagctgca cgcccggaat ggctttcaaa atctctctcg gcggatcata gacttcattg 3601021 taccggccca aatagcacga atcatggaag gtaatcgtct catgaagcgg gtgctgcggt 3601081 cttaattttc cgtttttcac aagctcggcc agcacttctg tatgatgata aacctcgcct 3601141 tcaaatccga aatccggata ttcgttttta aataaattgt atgcatgggg atcgatcgta 3601201 acgatttttt tgacatcatt tttttcaaat tcagaaatat tcttctcagc cagctcttgg 3601261 aacaaaaatt catttccgag gcggcgcggc gtgtctcctg aatttttttc tttattgccg 3601321 agaatcgcga aggacacgcc cgcgtgattg agcagcttgg caaaggaaat tgcgattttc 3601381 tggcttctgt tgtcgtaaga ccccatggag cctacccaga aaaggtactc aaattctttt 3601441 ccttcttttt tcatttcttt tacagtcgga atctcagcat ccggcgcctc gtcacgccaa 3601501 ttttcacgtt ccttgcggtt gagtccccac ggattccctt gccgctcaat acttgtcatt 3601561 gcgcgctggg cgtcactgtc catttttcct tctgtcagta cgaggtagcg gcggaggtcg 3601621 atgattttat ccacgtgctc attcatgacc gggcattgat cctcacagtt ccggcaagtg 3601681 gtgcatgccc aaatttcttc ctctgtgatg acgtcgccga tcaagcttgg attgtaatca 3601741 agcgccgctg cggcttcctg cgatccgctg cccgctgacg ccgcagccag ctgattgcct 3601801 ctcgtatgcc gaaacgctgc tgcgggcacc catggggagc gcgaggtgac ggcagcgcct 3601861 ttttccgtga gatggtctct gagacgcaaa atcaagtcca tcggagaaag catttttccg 3601921 gtgcctgttg caggacacat attggtacag cggccgcact cgacacacgc gtatagatca 3601981 agcagctgag actgtctgaa atcctcaatt tttcccgctc cgtagctttc tttcgtttcg 3602041 tcggtaaaat caattttttc aagttttccg gcagattcca ttcgattgaa aaagacgttt 3602101 gccgggccgg cgattaaatg ggcatgcttt gactgaggca cgtacactaa aaagctaagc 3602161 aagaatagga gatggatcca ccatgcgata tagaaaatca ccgccgcgcc tgttttcccg 3602221 acaccgctaa gcataaacgc aatacctgag gcaattggct cgctccaaga aagcccatgc 3602281 tcatgccaaa tcagattcat cccgttccca agcagaacgg tcagcattaa tcctccgata 3602341 aaaatgagaa cgagtccggc tttgaaaccg cgtttcagcc tcacgagctt ttcgatataa 3602401 cgtctgtaga atgcccaccc aacagcaatt aaaatgagaa acgtaacaat ttcctgaaaa 3602461 aaggtgaagg cgggatagac cgggccaagc gacagattcc ggccgggagc cagtcctttg 3602521 atgataaagt caattgctcc gaactgaacc aatataaatc cgtagaaaaa catgacgtga 3602581 atgattccgc ttttcttgtc cttgagcagt tttttctgtc cgaatacatt cacccatatg 3602641 gcgtgaagcc gttccttgaa ccgttgatca aattgttctt tctggccgag cttgatgtag 3602701 gccagtctcg ttttgaccaa gtaaacaaac aaatagacag cgtaagcggt tacaatcaga 3602761 aataataatg catttgcgat gagaaagccg ctcattccaa ttcccccttt ttactgataa 3602821 agaccgcgat cccctacccc cgaatctgta taagattatc tttatgataa ataatgaatg 3602881 agtgttcagt caataattaa attcctgctg ttcgggcaca ctacctttac tacggaaagg 3602941 agtgccggta tgaaggtatt tatcgtgatt atgatcattg tcgttatttt ctttgccttg 3603001 attctgcttg atatcttcat gggccgtgcc ggatacagaa aaaaggcgta cgagcctgtt 3603061 ttttcaaaaa agaagagtga catcgaattg atccactgcg gcgctgatct cgttgagcgg 3603121 atgatgaatg atattcgcca ggccgcctct tctgttcaca tgatgttttt tattatgaaa 3603181 aatgatgagg tcagccacaa tatgtatacc ttgctgaaaa caaaagccca agctggcgta 3603241 tccgtttatt tgcttctgga ttgggcgggc tgccgggcaa ttaaaaaaac ggcgcttcag 3603301 acgatgaaaa atgccggcgt ccatgtccat gtgatgaatc gtccccgttt tccttttttc 3603361 ttttttcaca tgcaaaaacg gaatcaccgg aagattacgg tgatagacgg aaaaatcggt 3603421 tatatcggcg ggtttaatat cgccgaagaa tatcttggaa agaaggcgaa gttcggcaat 3603481 tgggaggatt atcatctgcg catgatcgga gaaggcgtac atgatcttca aacgcttttt 3603541 gcttctgatc taaaacgaaa taccggaatc gaactgggtt cggatgtttg gccaaagctt 3603601 cagcaaggga ctatttctca caagatctat gcgaccgacg gttattccct tgaaaacata 3603661 tacttggcca acattgccca agcgaagaat cgccttacgg tttgcacgcc ttattacatt 3603721 ccatcaaaac cgcttcaaga ggcccttatt aacgcaagaa aaaacggcgt atccgtgaga 3603781 atcattgtac cgatgaaatc agaccatccg ctggtacgag aagcggcttt tacgtattat 3603841 tcggagctct tggatgccgg ctgtcttatt tatcgttatt atcaagggtt ttatcatgta 3603901 aaagccctca tcatagacga ccatctcagc attatcggaa cagccaactt cgataaacgg 3603961 agcctgttct taaatgaaga ggtgaatgtt gaaattgatg acgaagcgtt tacaagtgaa 3604021 gtctatgcca caattgagga ggatatgaaa aagtcggagc tgctgacgat ggaggatttc 3604081 agcaagcgca cattcaggca gcgcccggcg gaatggctcg gcagggcatt atcttatttc 3604141 ttataaagga gagttcctat gattttcaga ttcgggttcg tttcaaatgc gatgagcctt 3604201 tgggatgcgt ctcccgctaa aacattgaca ttcgcgcgtt attcaaagct ttcaaagact 3604261 gaaagaaaag aagcgcttct gactgtgaca aaagccaatt tgcgcaatac gatgagaacc 3604321 cttcactata tcatcggcca cggcattcct ttgtaccgtt tttccagttc gattgtgccg 3604381 ctggctacgc atcccgacgt gatgtgggat tttgtaacac cgtttcaaaa agagtttcgg 3604441 gagattggag agcttgttaa aacccatcaa ctgcgaacaa gctttcatcc aaatcaattc 3604501 actctgttta cgagcccgaa ggaatccgtc acaaaaaatg cggtaacaga tatggcgtat 3604561 cactaccgca tgcttgaggc catgggcatt gctgatcgct ccgttatcaa cattcatatt 3604621 ggcggcgctt acggaaataa agacaccgcc actgcacaat ttcatcaaaa tataaaacag 3604681 ctgccgcagg agatcaaaga gcggatgaca cttgaaaatg atgataaaac atatacaacg 3604741 gaagaaacgc ttcaggtctg tgagcaggag gatgttccgt ttgtctttga ctttcatcat 3604801 ttttacgcca atccagacga tcacgccgac ctgaatgtag cactgccccg catgatcaaa 3604861 acgtgggagc ggatcggcct tcagccaaag gttcacttgt cttccccaaa atcggagcaa 3604921 gcgatacgca gccacgccga ttatgttgac gccaactttt tgctgccact gttggaacgc 3604981 tttaggcaat ggggaactaa tattgatttc atgattgaag caaagcagaa agacaaggcg 3605041 cttctccgct tgatggatga attaagctcc atccgcggtg tcaaacgcat cgggggcggt 3605101 gcgctgcaat ggaagtcata aatgtgcaaa aataggttta cgacttgtca gctttgggaa 3605161 cttaggctat ataagacaac aatcgatgga ggagaaagat catgaaaaat atcaagtctc 3605221 tgaaagtagc cgcacaggcc tttactttaa gaaatttgat tcatctttat aaaatgtgcc 3605281 attccggaag ccacgaggtt tatatttatt caaagaaaac gatgtgcaaa atcaaaagct 3605341 taattgagct tgaaacgttc cgcatggctc ataatgaaaa ggaatatctg atcgtagttg 3605401 aaggaacaaa agcatcacag ctcattgaaa aattccaaaa tctcatcgag cctgctgaga 3605461 gagaagcgct ctaacttaca tacaaaaaag gatagacatc tgtctatcct ttttcttatg 3605521 ctcttacata atggagctga accgcttgtc caaattgttt tgtccctttt aaccgcagtt 3605581 ttgtttcatt tgttagttcg tgaaacagcg ggatgccgct tcctaaaacg acgggaataa 3605641 cagtgatgat gaattcgtcg atggcatctt ctttcataaa gtcattcaca agctctgccc 3605701 cgccagctat ccagatgttt gagccttttt cctgtttcaa acgggcagtg aaggctctgg 3605761 ctccctcatt gataaacgtc acatgttcat cttgataact gtcgggcgat cctgtaaaaa 3605821 catagcaggt tttatcctga tacgggaaaa ccggtgttag cactttaacg tgctcatatg 3605881 tgctccgccc taaaatgact gtatcaacag tctgataaaa atcactgtag ccgttgtcac 3605941 cttcaccttc aaattcatcc agccaatcga tgcttccatc ttcttttgcg atcatcccgt 3606001 ccaatgaaac agcaatgtac agcacagttt ttctttccat gttctcctcc tatcgatgca 3606061 ccatttgccc gaattgcgct tgatgcagcc tgctgtatag gcctccggct tcgatcaggt 3606121 cttgatgacg gccttgttct tcaataccgt tgtttgtgac gactacaatt ctgtccgcgt 3606181 ctttgattgt tgccagcctg tgggcgatga caagcgtcgt gcgcccctca gacaactctt 3606241 gaagcgcctt ttggatcgcc gcttccgtct ctgtatcaag ggctgaggtg gcttcgtcga 3606301 gaatcaagat cgacggattt ttcaagaaca tccttgcaat tgacagacgc tgtttttgcc 3606361 cgccggaaag cttcacgccg cgttcgccaa tcatagtatc caacccatcg ggcatgttat 3606421 ggacgagctc ttccagatgc gcctgcttca cagcttgcca aatgtcttct tctgatgcgc 3606481 ctagtcggcc gtaggcgata ttttctctaa gcgtgcccga gaataagaaa acgtcctgct 3606541 gcacgacgcc aatctgcccg cgcaacgaag aaagcgtcat gtcttttata ctgatgccgt 3606601 caatcgtaat gtcgccctcc gatgcttcat aaaaacgcgg aagcagactg caaagcgttg 3606661 atttcccagc acctgacgga ccgacgaacg ccaccgtttc ccccgcttga atggataggt 3606721 tgatgtcatt gaggacattg tgatggtcat catagccaaa cgaaacatgt ttatagcgga 3606781 tattgccctt caggccggaa acatctttcg aatcaggtga gtcctgaata tccggctctg 3606841 tctccatgag ctccatatag cttttgaaac ccgcgatccc cctcggatac atttcgataa 3606901 tggcattaat tttgtcaata ggcctgaaca gcacattcgt caagagtaca aacgccacaa 3606961 attccccgta cgataaggag ccgcgaatga caaaccacgt cccgcacaaa aggacaaaca 3607021 gcgtgacaaa ccgggtcagc atatagctga ttgaaccgtt tttcgccatg attttgtagg 3607081 aagaaagctt tgtgacacga aaacgctggt tgttgacggc gaagcgttct ttttcaaatg 3607141 cttcatttcc gaacgcctgc acaagccgga tgccgccgat gttattttct acacgcgcgc 3607201 tgaagtctcc gatatccttg ttcagcgtgg taaatgcttt ggtcattttt ttgttgaaat 3607261 aaagcgctag ccaaatgacg atcggcataa tgataaacgt taataaagca agctgccagt 3607321 taataaacag catcactccg aacgccccga gaatggtcat gaccgcaatg aataagtctt 3607381 ccggtccgtg atgggcgact tcaccgatat acattaaatc gttcgtgagc ttcgacatca 3607441 gcgttcccgt cttgttgttg tcgtaaaatt tgaacgagag cttttgcaaa tggtcaaaaa 3607501 gcgactttct catatcagtc tcaatattga taccaagcat gtgtccccag taggtcacga 3607561 tatactgaag agccgagctg agcgcgtaca ccgcaaataa cccgattgag gtcgcgatga 3607621 tcagtcccca gtccctgccc ggcagcaagg tatcaataaa ataattgacg atcaaaggaa 3607681 aactcagctc cattaaacct cccgcgatcg ctgagaaaaa gtcgagaaag aacaacgttt 3607741 tatatggttt ataatatgaa aaaaattgcc gcagcaccct atcttccccc aatgtataaa 3607801 taactgataa tatttctcaa ttatactata cacgggctgt tttgtaagat cagatttctt 3607861 ttttcttaca gaacacctga aaacaggcgg gcaaacgact cttttgtccg gtcagccaca 3607921 cctcttttat aaaagccgac agggctgagc ttttcacttt cctgcatatc ctcttcaaaa 3607981 tgggcctcaa gggttcggat cgcttcggca tccgtgaaga acacattcac ttcaaagttg 3608041 agctgaaagc tgcgcatgtc catattcgcg gtaccgacgg aggcgagatc gccatcaatg 3608101 atcatgactt tttgatgcat gaagcctttt tggtaggagt acacttcaat gccctcaagg 3608161 agcagctccg ggaaatagga cctcgacgcg tattgggtca aaaagctgtc gttcttctcc 3608221 ggcaccataa cccttacctc tacccccttt gtcgccgctg cttttagcgc cgtgcgaatg 3608281 gattcattgg ggacaaaata gggcgtggcg atccatattg atttctgcgc tgaagaaatc 3608341 atttcataat aaaggtcgct catgctttcc ttcatgtcag ggcctgtcgc gacaatttga 3608401 taaatgcctc ctccttccac gggaaccggg gtattgtact cctcttgatc aattagcact 3608461 tcattggaga catattccca atccagcata aagatagcgt ggagcgtttg cacaatttcc 3608521 ccctcaagcc gcaggtgtgt atctctccaa aatccgatgt acggatctct gctgatatat 3608581 tccttcccga catttaatcc acccacaaaa ccggttttcc catcgatgat cacgattttc 3608641 cggtgatttc tgaaattcag cttctggttg aaaaacccgt atttcagcgg agaaaacggg 3608701 acgatgtcca cccccgcttg tttcattctc ataatatctc ttcttgccag cttcatgctt 3608761 cctgccgcat cgtataaaaa cctcacctcg acaccctggc gcgctttctc catcataata 3608821 tccatcatgc cgcgtccgag catgtctgat ttaaacatgt agtattcaat atgtatgtaa 3608881 gattccgctt ttctcattgc tttgaaaatg tccgggaagg tttcttcgcc gtttttcagc 3608941 actttgatgt tgcttttcgt attgatattc atatgggcag ccctgatgga atatgtaaag 3609001 aacctctctt gattgtcctt cagccctgtc acttcgggcg tttcctcctt gtcaaacagc 3609061 ttcctgagct tttccctgtt gtacattcgt tttgtcttaa acagctttcc ctttacataa 3609121 agctgtcccg aaaacagata aaacacgtag ccgacgattg gaaaaaagac aagaatatgg 3609181 atccatagca gcgtgtgctg cgaggtgcgg ttttcaagaa ttaatgaata gatgctgaac 3609241 aaaataatgc ttatatagca aagcaatcct ccgtaaaact caagtctgga aaccggaaaa 3609301 aaccaaatga catatgcccc gatgagcatc atatataaaa agaaaaattc cagtctcctt 3609361 ttcagcatcc tgattctctc caatctgatt caattacctc tgtattacct cttttttcta 3609421 atcgataaac cttgtaagta aaaaacctct ccgccaaagg aggagaggtt tagagaaaac 3609481 taactgtcac ggaattcatc cgcatcgttt ctgcagaaat aaagcaagac tattggcaac 3609541 gccgagtgac aacatgagcg gcaagctgaa cccgctcagc actccggcaa gcgccgaaaa 3609601 gaaggcggcg ctgtgactgc aaatacggtg gatagagtaa atttgatacc cattctgatg 3609661 agagaaaata tataaaacgg gaaattgatc agaaagatat aaggagttag tcaggctgaa 3609721 tcataatctg gctgttccgc cggtttaaaa tgagtaaaat ccttgatgtt atttccatat 3609781 acaaacataa caggattccc ggcagcccag ccattacctt ggcagaaaaa accccctctt 3609841 gcaaggggga ttttcacgag cgtttccgat atacaacgta gctgcgggtc agatacttga 3609901 gcggcagact gaacacatga accaatctcg taaacggcca caggataaaa acgacgtatc 3609961 ctatcacaat atgaaactta aaccatagcg ggacactctc catcaaagag gcgtcaggcc 3610021 tgaacaaaac gatttccctg aaccagggcc cgactgtggt ccggtaatca aatcctttcg 3610081 aatcaatgtt gagaaacgtg gccgcaacgc ctgacagcat catgaacagc agcaggagga 3610141 gcgtaaggat atcggatggc gagctcgttt tgcggattct tttgtcaaac agccttctgt 3610201 acgtcaggat gacaagtccg gtacatgccg caatgcccgc cggcaagcca gcgccaatcg 3610261 ccattttgtg atacatatgc tctgaaatgc caagggaagc atacacgcct tctgggatca 3610321 gaatccccat gacatgcccg ccgacaacgc acagcagtcc ccagtgaaaa agtgtgctgc 3610381 cagccgcaag ttttttcttt tctaacagct cgcttgattt cgccgtccag ccaaattggt 3610441 catgctgata gcggtaaata tggccgccga taaagattgt caatacaatg tatggcataa 3610501 taccccagag gatctgcccg ctcatgcctg aacagcccct tcaacgcttt cacgtacgcc 3610561 aatgttttca agcgcggcca gcagcacgtg cagcagttca gcgtatatac tgtcattttt 3610621 ttcgagacgg gatgccagct ccctcacatt ggacagatat ttctcaaaca cgcttctcgc 3610681 tgcttcaatt tctgcagccg cagcaaattc cagcatcagc ggcagataat caggcagctc 3610741 tttctctgtc ggcaggaaac cggattgctc gtatgtgttt tttaaatgca gcaattcaat 3610801 gccgcgttcc ctttgctcgc ctgagttaaa gtaggtgaca tacatatttg tttttttccc 3610861 gaagtcgaat gtatagacat agtgttcaat cagcgcttcc ggagaatagc tggctgacgt 3610921 ctcgaaaaag tgcagcagct tctcccggat ttgccggttg ccgatttctt ggataagagc 3610981 cttccaatcg ggaagctcgg ctctccactc ttcatccgga taagagagaa gacaggaaag 3611041 agcagagaac gtgatttgcc ggtctgtggt gttcatcttg ttacacctca tttatcaaaa 3611101 gttagaaaca ggagccgggg ccgcctgaaa atgataagcc gcagcttcct tgttcagcgt 3611161 ataaatctga tacttcttct cgatggctgc tcggaatcac aaagcggtca tcatatttgg 3611221 caatcgcaag cagccgatac atatcttcaa tttgctgttc tgttaagccg acactggaga 3611281 tcagttccgg atcgattgat ttattcgtct ggaccgctct catatactgg cgcatgacag 3611341 acattttctt taatgttgac cgaatatgat ccgtatcacc ggctgttaac agctgcgcca 3611401 aataatctat cgggattctc atttggtcga tagccggaaa aatatcttcc gccgtttgcc 3611461 ggctgccttt tccttcaaag agattcataa tcgggctgag cggcggaatg taccacacca 3611521 ttggcagcgt gcggtactca ggatgaagcg gcagcgcgat cttccagtca atgatcattt 3611581 tatagatcgg tgattgctgc gcggcctcta tccattcagc cggaatgcct tgttcttttg 3611641 ccagtttggc aacctcagga tcattcggat caagaaaaac gtccaattgg gaatggtaga 3611701 gatccttttc attttcaaca gatgccgctt cctccacttt gtccgcgtca tatagcatga 3611761 cgccgaggta gcggattctg ccaacacacg tctcagagca gatggttggc agtcccgcct 3611821 ccaaacgcgg aaagcagagt gtgcattttt ccgctttgtt cgtttgccag ttaaaataga 3611881 cttttttata aggacaggat gagacgcaat atctccatga acggcatgcg ttttgatcca 3611941 caagcacaat gccgtcctcc tcgcgtttgt acatggcgcc ggatggacag gatgagacgc 3612001 atgccgggtt gatgcagtgc tcgcaaatac ggggcaaata catcataaag acgtcatcga 3612061 attctgtttt gatcgattcc tccatctttt gtacgttggg atcttcaagt cccgtaatgt 3612121 ggccgcctgc gagatcgtcc tcccagttcg gtccccattc gatattcatg aaatcccccg 3612181 tcaaggacga tttcgggcgt gctaccggct ggtgtttttt ctgcgggctg ttcgttaatg 3612241 tttcataatc atagttccaa ggttcatagt aatcatcaat tgacggctga ttcggattat 3612301 agaaaaggcc tgcaagccga ttggttttcg agcccgattt cagctcgagc tttccttttt 3612361 tcaatgtcca gccgccttta tatttgtcct ggtcctccca ttgcttcggg tagccgatgc 3612421 ccggctttgt ttctacatta ttgaagtaca tatattccgc accggaacgg tttgtccacg 3612481 tgtttttgca ggtgacgctg cacgtgtggc agccgatgca tttatccaag ttcatgacca 3612541 taccgatttg cgctttaatc ttcaagccaa tcgacctcct tcagcttgcg gatgacgacg 3612601 ttcaggtcgc gctgattccc cgttggaccg taataattaa agccgtagct gagctgggcg 3612661 tagccaccga tcatctgtgt cggcttgacg tgaatccttg tcgggctgtt atgggtgcct 3612721 ccgcggttat tcgtcagctt tgtgccgggc acgttgatgt ggcggtcctg ggcatggtgc 3612781 ataaacgcca ttcctttagg aatccgatga gacaaaacgg ctctcgcgac gacaacgccg 3612841 tttcggttga agcattcaat ccaatcgttg tctttgatat ccgtgtcctc tgcatcatct 3612901 ttattcatcc acacggtcgg cccgccgcgg aacagcgtca gcatcggcag agaatcaaaa 3612961 tacatgctgt ggacagacca tttattatgc ggcgtcaaat aattgaggac gatttctttt 3613021 ccctcttgat caggccgttt gctcagaaac gggcgatgct ggaggatcgg tttgaatgtc 3613081 gccatcgttt caccgaattc catcatcagt tcatgatcga cataatagga ttgtctgcct 3613141 gtcagcgtcc gccacggaat taatttttca acattcgttg taaacggcga atacctgcgc 3613201 cctccttttt cagagccggt aaacgctgga gacgtgatca ccgttttcgg ctgggctgta 3613261 atttgttcga acgtaaagca ttcttcctcg cgttcttccg ccaggtcttt cagcttcagg 3613321 ttcgtgatgt tttcaagtga ttcccatgct tttactgcga cctttccatt cgaagtggat 3613381 gatagggtta aaatcgcttc tgcagcctgc tttgcttcac ttatatttgg acatcccttt 3613441 gccacgctgt ccgaggtgat ttctcccagt ctctgtttga gtgattcata ttcatcggct 3613501 attgaccagc tcatcccttt tgttccgctc ggctttaaag caacgttcgg accaagtgca 3613561 gtcattttat gaaaaatgtg tttgtaatcc cgttcaacga cttggatgtt cggcatcgtt 3613621 tttcccggaa tggcttcaca ttcgcctttg ctccagtcat tgattttgcc gaatggctgg 3613681 gccaattcct gcatggtgtc gtggagcagc ggtgtcgcaa ccacttcttt caccggctcc 3613741 atatcgactt cttctgccag atcggaaacg gcttttgaca gcgccttgaa aatatcccag 3613801 tctgacttcg attcccacgg agccgagatc gcaggagcaa atggatgaat gaacggatgc 3613861 atatctgtgc tgctgagatc gtgtttttca taccatgtcg ccgccggcag cacgatatcg 3613921 gaatacagcg ccgtacccgc cattcgaaaa tcaagattga ttaataagtc gagctttcct 3613981 tccggcgcct gctcccgcca tttgatttct tctgggcgga tgctgtcgct gtcgtcattc 3614041 attaaaccgt tcgttgtccc cagcaaatgc ttgagaaaat attcatgccc ttttcctgag 3614101 cttgagatca gatttgcccg ccatacaaag agattccttg ggaaattcac ttcattgtca 3614161 ggatcttcaa tcgcgaattt cagttttttc tcttggagct gtgaggccac gtacgcacct 3614221 acgtcttcag gtgttgctgc ccctgctttt tcagcttctt tatacagatc gatgccattt 3614281 tgattgaaag tcgggtaaga cggaagccac cctagccgcg ccgccagcac attgtaatca 3614341 gcgtggtgct tgtagcggga tgaagcagca atcggtgatg ccaaatcact gatcggctgg 3614401 tcctcataac gccactgatc tgtcgcaaag tagaaaaatg aggtgccatt ttgcagcttg 3614461 ggcacgcctt cccagtcctt tgcagttgca atcgtctgcc acccttcagc aggtcggagc 3614521 ttttcctgcc ccacgtaatg ggcccagcct ccgccgttta cgccttgggc gcctacaagt 3614581 aaaacaagat ttaacactgc tcggtagatc gtgtcggagt tgaaccagtg gttaatgccg 3614641 gcccctacga taatcatgga ccggccgtct gtatcgatcg cattttgggc aaactctctg 3614701 gcaatcttaa cgacagcttc ttttttgatt cctgtcattt gttcctgcca ggcaggcgta 3614761 aacggctcag ggtcatcata ggagacagcc gatcgttcgc cgatgccccg gttcacgccg 3614821 tagttagcca gtatcaagtc aaacacggtc gtgatgtacg tttcttcacc gttcaggttc 3614881 atttttttaa taggaagatc ccgctcgagc actttgtttc cgtcatttga aaaatacggg 3614941 atgcgcaccg tgccgatttc gtcctctatt cccagcacag agagacgggg ttcaatcggt 3615001 tccccggttt cttcatcaat catgtgcagg ttccatttct gctgcccgtc ccagcgcgag 3615061 cccattgtcc cttggggtat ggcaaatgaa cttgtctgtt catcccaaac cgcaggcttc 3615121 cactgatcat gctttgtctt ccgcccgatg tccttcgcat gcagaaaccg tcccgctgtg 3615181 tatacgccat tttcttttga cagagtgacg agaaatggaa aatcagtgta ttgcttcgcg 3615241 tactcaataa aacgttcagt ttcttggttc acgtaaaatt cctgcagaat aacgtgaccc 3615301 atcgccatcg caagcgcccc gtcagtccct tggcgaatac tcagccagtc atccgcgaac 3615361 tttgaggatt ccgcaaaatc tggactgatc gaaatgacct tagcgccttt atagcgggcc 3615421 tccgccaaaa aatgcgcgtc aggcgttctc gttaacggaa cgttggagcc ccatgtgata 3615481 atatagccgg aattgtacca atcactgctt tccggaacgt ccgtctggtc accccaaatt 3615541 tgcggggatg ctggaggaag atccgcatac cagtcataaa aactgagcat agggcctccg 3615601 attaacgaca taaaccggga gcctgatgcg tggctgatca tggacatggc cggaatcgga 3615661 gaaaaaccga cgtttcggtc aggcccgtat ttcatcactg tatacagcag agaggctgaa 3615721 atcagcttca gcacctccgg ccattcagcg cgcacaaaac cgcctttccc tctcgcctgt 3615781 ttataggact tcgctttttc agggttttcg acgatcgatt tccaggcttc caatggattt 3615841 tgatgcgtct gcaatgcctc ccgccacaaa ttgatcagca caccgcgcac gtatggatat 3615901 ttcacacgga gcgggctgta gatataccat gaaaaactgg ccccccgcgg gcagcctctc 3615961 ggttcaaaat caggcatatc cgggcctgtt gatggataat tcaaattttg cccttcccac 3616021 gtgactattc cgtttttcac ataaatattc cagctgcaag accctgtaca gttgacgccg 3616081 tgggtggagc gaacgacttt gtcgtactgc catctgtttc tgtatacatt ctcccaatcg 3616141 cgatcctcgc gggtagtttg gctatgttta tttgaatggt gttcgatagg agagaaataa 3616201 ttcaatctcc taaacaacgg actccttttc tttttcttca tgagagttca ctccttccga 3616261 gtcaggtgat gctaagttca ctataaacag agacagcgtg tttccttgtg aactatgtca 3616321 cacactctgc ttttttcaca aaatgttcac acaaaggaga aggaaggctg cgttcaggca 3616381 ggacgcttgg gtcattagct gcctttcatt caaagatcaa aaaaaaccgg ctctatttaa 3616441 gaaccgggct cagcgttttc atcctgtgat gtatgcagat accgcaaaaa taattgatag 3616501 gaacaaaaaa cattttgctg aagcatagcc aaaaagttca tttgcagctg cggatgataa 3616561 gacatcattt tcttaaatat gtaatatggg atgttgagaa tcagaatgtc tgaagtggca 3616621 ttgactgaga taaagggcga taaataaagc ccgccttttt catcaatcgg aaacacatcg 3616681 cctttttccc acagcgcaac ggttttcgac ccttcaggga gccttgtgtc cataaaacgg 3616741 acactgcctt ttaatacaat ataaacagat tgagaatgaa gaaaagatgg agactgatca 3616801 catgaaccgc ggataaacgt gccgtttttc agcaaggttt cgacaatgga tagaggcact 3616861 tcattaaaca taggaagttg tttcagaaat aataaatagt cacactgatt cataggaaaa 3616921 cctcctgtgc taaggatagc tttagtgtag ctcgactgag cctgtacagc agtgatgtat 3616981 ttcacagcct gtatgatgaa tgtcacttat caggagggtg aatgcattta taatgaaaga 3617041 aaaaaggagg atttcgatga aggcgctgat tccgaagcag cacggggcgt gggcgatgct 3617101 gctgatccca tttttactcg gcatggtcaa gggaggcccc gttatttggc atattccgct 3617161 cttccttggt tggcttttcc tatacttagc ggtttatccc gttacgcttg ccttaaaaaa 3617221 gaaacaaagc aaaccatatc aaaagtggat gtgttattac ggttttccca cctgctgctt 3617281 tttgatgatc tcggtctttc ataagccgcc tctcatctgg gtgggcgttt ctttactgcc 3617341 gctgtttctc atacatatgt attttgcccg cagaaaaaac gaacgagcct tattgaatga 3617401 tgttgcaggt gtcttgttct tttgttcggg cgggtttgcg agctgctggc tggggatggg 3617461 aacccttgac ggctgggctt ggtttatttt cttgcagtct gctttatttt ttatcgggag 3617521 ttccttttat gtgaaatcgg tgatccgcga gagaaaaaac agggcatttg catactggtc 3617581 atggggatat cacctgctgc tccccttttt atccgctctt ttcggagcag gatgggcgtt 3617641 tctcgctttt atcccgagca gcttgcgggc atggtttttt catggaaggg attggcccgt 3617701 aaaaacgatt ggcattctgg aaatcgtgaa tgcctgcttc tttcttgccg tcatgtgcct 3617761 gtttatcaca aggtaaaaaa acaaggacac cgctgtcctt gtttttttca gtcaatattg 3617821 caaatctcca gcgggcaatt ttcacactca atctcacatc gtaaatagtc ccgcttgtgc 3617881 aaaataattt ttccggattc gtctatcgaa ataacccctt ttttgcggag atctccgagc 3617941 atacgattga cgctttcccg tgcagccgcg caaaactttg ccaaatcctg atttgtcagg 3618001 acaatgttaa tcagaatgcc gtcgcttcgc tccactccgt agctgtttga taagcggata 3618061 agggtagaat agagcgcccc ctttttgcca tgaagaagca gatccctgat tttggactga 3618121 atcttccgga ggtgcgtgct catccatttc atgaactcaa atgtcaaagc gccgttttgg 3618181 attaattctt tttccagctt atttttatta atgacgagca cctcgccatc ctctagtact 3618241 tttgcactga gcatatacct tggttcttca gtgaaaagtg ttaattctcc gacgatatca 3618301 tgcttttggc agattctaag cgtcaggtct tttccgtcag atgtcagctt gccgatttca 3618361 atgagtcctg attgaatcag ataaagctct tctgcatcca ttccttcccg aaacaaatac 3618421 gtgtgttttt ccatttttct tttcgtgctg atcgattcca gcaattcata cagatcgctg 3618481 gatataagat cactatcaga tggtcgaaca gagagaaaat tcatgagctc acctcgaaga 3618541 aagtcacgtt gtgtgtttat tgtaacgtga attgatttgt acccatcgag aaaaaactaa 3618601 caatcttgtg aatgccccag tgttagttga tgctctggct gtttctctcc gtgtgtgttt 3618661 tcattctttc ctgccaatac atccatatga caaggacaaa actggctaac gccacctctg 3618721 aaagcgccat aaacccgatc gcgtactggc ctgttgcctg aaatacactc gccaatatga 3618781 gcggaggaaa aaagccgcct aaaccgccca tggcagacac aatcccattg gcaatccccg 3618841 cttgcttcga aaaatagaaa ggcaccagtt taaaaacagt tccgtttcct atgcctgagc 3618901 agacggccac ggttaatgat ccaaacgtat aaaggccgat tgtcggcgag aacgatagga 3618961 taatgcctga taatgtaagc ccggcaaaaa caaacatcaa gatgcggagc gggctcattt 3619021 tatcagccag gaatccgccc gcaggcctga gcagcgtaga aaccgcaata aagccagccg 3619081 tccgcaagcc ggcatctgca ggattcagcc caaaatgctc caccagaaag ttcggcagat 3619141 agatagtgaa ggcgacaaag gcaccgaacg taataaaata aaacaggctc agaaaccata 3619201 gcacatgatt tcggtaaaca gctttgattt gagtcttaac agaaactttg accttcttct 3619261 catgcctgtc gccaaacaat acgtgcagta aggcaaagac agccagcaaa atcagataca 3619321 tttgcacggt tgatttccac ccgacggctt gagcgataac cggcgctgca aatgtcgtaa 3619381 cggctgtccc gatatttcct gcaccgtaaa tcccattgac gacaccgtgc ttttctttcg 3619441 gataatattt cgggagggag gtcaccccaa tggaaaacac cgctcccccg atccctaaga 3619501 aaaagccgcc tgcgattaaa tcaaacagag aatccgcgat actgatccaa aatacaggaa 3619561 ataaaagcag gatgaagctg accataaaca tgagccgcgc gccaaacctg ttcgttaaat 3619621 accctaaagg aatgcggaga agcgacccga ggatcacagg aatcgcggtc actaaagaaa 3619681 tctcaccctt gcttaaatga atatctaatg tgatttggga aatgagtgat gaaatcagca 3619741 cccaaaccat aaaccctgcc accaagctta atgactgtaa cgataattga atgtgttgac 3619801 ggttgatcat ttggcttgcc cctttcaatg attcaataat cagtcttatc atacaaaaac 3619861 tagccaaaca ggattgtgaa ttacatcaca cgtttttctc ataaaaaaag gacaaagccc 3619921 gaagactttg tccttttgat cgtgattaca ttttttccgg agccgatacg ccgatcagct 3619981 gaagcgcatt gttcagcgta atttgcgttg ccttcattaa agccaggcgc gcgcggcttt 3620041 tctcttcatt ttcagggtcg atgactttct ctgcgttgta gaagctgtgc agagcagaag 3620101 ccagatcata aatatagtta gtgacacggt gcggaattcg tttttccgct gcttccgcca 3620161 ctgcctctgg gaagccgccg atcgttttca gcagatcgta ttctttttct gattgaatat 3620221 ggctgaaatc aagatctgcc gccggtttaa gcccctgctc ttccccttgg cgaagcatgc 3620281 tgcaaatacg ggcatgcgcg tattgtgcat aatacacagg gttttcgtta gatgttgata 3620341 cagcaagatc taagtcaaaa tccatatggg tgtctgcact tcgcattgca aagaagtaac 3620401 gcacggcatc caagccgact tcttcaatca ggtcacgcat cgttacggct ttaccggtcc 3620461 gtttgctcat tttcattttc tcgccgtttt tgtaaaggtg aacgagctga atgatttcta 3620521 cttcaagcgt tcctttttca tagcccagcg cttcgattgc cgctttcata cgcgggatgt 3620581 agccgtggtg atcggcgccc caaacgttga tcagcttatc aaagccgcgg tcaagcttgt 3620641 ccttatgata cgcgatatca ggaagaaggt acgtgtacgt gccgtccttc ttgatcaata 3620701 cgcggtcttt atcatcgccg aaagtcgtgg aacggaacca agtcgcgccg tcttcttcat 3620761 agacgtggcc tttttcgcgg agcgcttcaa gcgccttgtc gatttttcca ttttggtaca 3620821 gtgaagtttc tgaataccac acatcaaacg gcacacggaa gttttccaag tccttgcgaa 3620881 gcttttccag ctcgtatttc aggccgtatt cacggaaaaa cgcgaggcgt tcactttcct 3620941 cttcgttaac gaaacgatca ccgtattcct cagcgagacg ctttccgatc gcaatgatat 3621001 cctcaccgcg gtagccatcc tccggcatcg gtttttccaa tccgagtgct tcaaagtaac 3621061 ggacttcaac agaaagcgcc agattgttga tttggtttcc cgcatcgtta atgtagtatt 3621121 cgcggcttac atcgtaaccc gcttttgaaa gcacgttgca caaggaatcg ccgacagccg 3621181 ccccgcgcgc atgcccgagg tgaaggtctc ccgtcggatt cgctgatacg aattctacct 3621241 gaactcgttc accgtttccg atgttcgttt ccccgtatgc ttcccctgct tccagtacag 3621301 acggaatcag ctttgttaaa tattgattgt tcatatagaa attgataaaa cccgggccgg 3621361 cgatatccag tttttcaatc gaagccttcc ctttatcaaa atgggcgaca atctcttcag 3621421 cgatttgacg cggcgctttt tttgccactc ttgccaactg catcgccata ttcgttgagt 3621481 agtcgccgtg tgttttatct ttcggtgttt ctaaaacaac attgggaatc tggctttctt 3621541 cagccagtcc cgctttcaga acggccgctt tgatttcttc tttcagcacg tccttcattt 3621601 gttccgcaat gttcatgcgt gagttcctcc ctcatacgtg atcgtcatat tatgtaaatg 3621661 ctcctgctcg tctccgacat gcatgtcata tgcgatgctg atacggcctt tttcttcatc 3621721 gagatcagat tgaatcgatt ttgtgcttgt tttcagctca agctcaccaa atgacatttt 3621781 atatttagca attgtggaag ctcccgttac gaaacgctga ttcattttga cagcgcctga 3621841 cctcatgacc aggacttcgc cttcgcttac tttcacaatc gttttgactt tgcctaagtc 3621901 gtgttcttca taataagata gatacacttt attttgtttt acatagtaaa atccggtggt 3621961 gcggaattcg atgacttctt ggtttccgtc atcctcgatc acagacttca catggagtgt 3622021 tatcggtgtc tcttgcttca ttctgacacg tccttttcat cattccactt tgacttgaat 3622081 agtataatca ttcggtttgt aaacttcaac tgcttctatc ttaccatcat tgctcatcag 3622141 atttgaagat aaacctcata aaaagcattt ccttatatag aagagaaaat catatcacta 3622201 attaccttta ggaaatgtta catttttccg aaatctatca tttccttttc acattttttt 3622261 caaaatatat gtattgaatt agtaatttga tagttttaag ataaaagtac aacatagatc 3622321 tgctagaaaa acaaaaaaag ggaggattca attatgaaaa aagctgtcat tgtagaaaac 3622381 aaaggttgtg caacatgctc gatcggagcc gcttgtctag tggacggtcc tatccctgat 3622441 tttgaaattg ccggtgcaac aggtctattc ggtctatggg ggtaaggatc tcccaaaagg 3622501 gcatagtcat tctactatgc cctttttaag taaattacaa tttttaacta aaatctacct 3622561 cttggatata catacacaac cgtttttcat ttgaatcata tgtatagggg atggtatttt 3622621 gtttatagag cagatgtttc catttattaa tgaaagtgta agagttcacc agcttcctga 3622681 gggcggcgtg ttagaaatcg actacttgcg cgataatgtc tccatttctg actttgagta 3622741 tttggatctc aacaaaacgg cttacgagct ctgcatgcgc atggatggcc aaaaaacagc 3622801 tgagcagatt ttagctgagc aatgtgcagt gtatgatgaa tcaccggaag accataaaga 3622861 ttggtattac gacatgctca acatgctcca gaacaagcag gttattcagc ttggaaaccg 3622921 ggccagccgc catacaatca ccacgagcgg aagcaatgaa tttccgatgc ccctgcacgc 3622981 cacctttgaa ctgacgcacc gctgtaattt gaaatgcgcc cactgttatt tggaaagctc 3623041 acctgaagcg ctcggcaccg tgtcgattga gcaattcaaa aaaacggctg atatgctgtt 3623101 tgataacggt gtattgacat gcgaaatcac aggtggagaa atttttgtcc atccaaacgc 3623161 caatgagatt cttgactatg tgtgtaaaaa gttcaaaaaa gtcgctgtct taacaaacgg 3623221 aacactcatg cgaaaagaga gcctggagct tttgaagact tacaagcaaa aaatcatcgt 3623281 cggcatttct ctagatagtg tcaattccga ggtccatgac tcctttagag ggagaaaagg 3623341 ctcttttgcc caaacttgta aaacgataaa attgttgagt gaccacggta tatttgtcag 3623401 agtcgctatg tctgtcttcg aaaaaaacat gtgggaaatc cacgatatgg cccaaaaggt 3623461 tcgggatctc ggggcgaagg cgttttctta caattgggtt gacgatttcg gaagaggcag 3623521 ggatattgtc catccaacga aagacgccga gcagcaccgc aagtttatgg aatacgagca 3623581 acatgtgatt gatgagttta aagatctgat tccgattatt ccctatgaga gaaaacgcgc 3623641 ggcaaattgc ggcgctggct ggaagtccat tgtgatcagt ccgttcggcg aagtacgtcc 3623701 ttgcgccctc tttccaaagg aattttcatt gggaaatatt tttcatgatt cctatgaaag 3623761 catctttaac tcccctctcg tccataaact gtggcaagcg caagcgccgc ggttcagcga 3623821 acattgcatg aaagacaaat gcccgttcag cggctattgc ggaggctgtt acttaaaagg 3623881 gctgaactct aacaaatatc accggaaaaa catttgctct tgggcgaaaa atgaacaatt 3623941 agaagacgtg gtccagctta tttaggaggg aaacgatttg tcaccagcac aaagaagaat 3624001 tttactgtat atcctttcat ttatctttgt catcggcgca gtcgtctatt ttgtcaaaag 3624061 cgattatctg tttacgctga ttttcattgc cattgccatt ctgttcggga tgcgcgcgcg 3624121 gaaggctgac tcgcgatgag cattttggat atacacgatg tatccgtttg gtatgaacgg 3624181 gacaacgtca tcttagaaca agtggattta catttagaaa aaggcgccgt ttacgggtta 3624241 cttggggtaa acggcgccgg aaaaacgaca ctgattaata cgctgacagg cgtgaaccgc 3624301 aatttcagcg ggcgttttac actgtgcgga attgaagcgg aggccggcat gccgcagaaa 3624361 acatcagatc agctgaagac tcaccgttac ttcgccgccg attatccgct gctatttaca 3624421 gaaattacgg cgaaggacta tgtgtctttc gtccattcgc tttatcaaaa ggatttttca 3624481 gagcagcagt ttgccagttt ggccgaggcc tttcattttt cgaaatacat caataggaga 3624541 atttcggagc tgtccttggg gaacaggcaa aaggttgtat tgatgacagg cttattgctg 3624601 cgcgctcccc tgtttatttt ggatgagccg ctcgtcggtt tggatgtgga atcgatagag 3624661 gtcttttatc agaaaatgcg tgagtactgt gaagcaggcg gaaccatttt gttttcttct 3624721 catctgctcg atgtcgtgca aagattttgt gattatgcgg ctattcttca caacaaacag 3624781 atccaaaagg tcattccgat tggagaggag accgatctgc ggcgggaatt tttcgaggtg 3624841 atcggccatg aataacataa tccctatcat gtctttgctg ttcaaacagc tttacagccg 3624901 gcaagggaaa aaggacgcca tccgcattgc cgcaggcctt gtcattctgg ccgtgtttga 3624961 aatcgggctg atccgccagg ccggcattga tgaatcggtg ttgcgcaaaa cgtatatcat 3625021 actcgcgctt cttttgatga acacatatat ggtgtttctt tccgtgacat cacaatggaa 3625081 ggaatcttat atgaagctga gctgcctgct gccgatttct tcacggagct tttggctcgc 3625141 ccagagtgtc gttttgtttg tcgatacctg tttgagaaga actttattct tttttatttt 3625201 accgctgttc ttatttggaa acggaacgct gtcaggggcg caaacattgt tttggctcgg 3625261 caggttttcg ttttttaccg tttactccat tattttcgga gttgtgctaa gcaaccactt 3625321 cgtcaaaaag aagaacttga tgtttctgct gcatgcggcg atattcgcct gtgtatgtat 3625381 cagcgccgct ttgatgccgg ccgccacgat tccgctttgc gcggttcata tcctgtgggc 3625441 ggtggtcatt gactttcctg tctttctgca ggcgcctccg cagcagggca agatgcattc 3625501 atttatgcgg cgatctgaat tttcgtttta caaaagagaa tggaaccgat ttatctcttc 3625561 taaagcgatg ctgttaaatt acgcggtaat ggcggtattc agcggcttct tttcgttcca 3625621 gatgatgaac accggcatct tcaatcagca agtgatttat atcgtgattt ccgcgctttt 3625681 gctcatctgc tcgccgatcg cccttttgta ttcgattgaa aaaaatgacc ggatgctgct 3625741 catcacgctt ccgatcaagc gaaaaacgat gttttgggcg aaatatcgct tttattcagg 3625801 cctattggca ggcggatttc tccttgtcgt gatgattgtg ggtttcatca gcggccgttc 3625861 gatttcagtt ctcacttttt tgcagtgcat tgagttgctg ctggcgggag cgtatatcag 3625921 gttaactgcg gatgaaaaaa ggccctcctt cagctggcag acggagcagc agctatggag 3625981 cggtttctca aaatatcggt cttatctgtt ttgtcttccc ctattcttag ccatattagc 3626041 cggcaccgct gtatccttgg cggtcattcc gatagccggt ctggtcatag tctattacct 3626101 gcaaaaacag gatggtggtt tctttgatac aagcaaaaga gaacggcttg gaagttaacc 3626161 tgctgaagac tcatcaattt tcaactattt caatcgccgc gagctttctg aaaccgatcg 3626221 aaagcgcggc ggaacctgag gaagaaacga tttattttta cggcgccgcc gcatacctga 3626281 aggagcaaat cattgacgct tttggttatg ctgccggcag ccgtttcatg tactcagcga 3626341 atctcttttt tgatcagcag ctgaaaacct gcgggacccg tttgattcac ccattatata 3626401 acgggaatct tcatgttgac gccctgatga aaacttttgc agacttgtct ttcccttctt 3626461 ctctttcatt cgaagcattt gaaaaggcca ggaatgagct gctgctgaaa atcgaaaaga 3626521 aattcactga tcccttctcc tactcggcgg ctcgcttggc tgaggaggtc ttcggaaacc 3626581 cgatgtacgg cacaggcatg tttggccgga gagacaggat aaaggcgatt catcctaaac 3626641 ggtttctcga cgcaacggac tttatcgttg atttagtgtc ccagcaaaaa cagctgaaca 3626701 tattgggaca agtacaagca tgtgatgttc ggggacatgc cccgcaaacg tccgctgtaa 3626761 cgtccggaag aatacccgta aaccggcatg tttttgaaac agagacacgc agcgctgcag 3626821 gtccttccgt cttgacactc ggatttgact gcggagagat gaaagatgcc agcgattata 3626881 tcaaaataca gctaatagac ggattactgg gaaagtacgg ccattccgct ttattcaagc 3626941 acttcagaga gaaggatctg gcagtctatc acgttatcac ccgttacgat gtcatgaaca 3627001 atttgctgct tgtttcaata tgtacagatc agcttcatga gaaagacatt cccccgcgcg 3627061 ttttggaagc tgtctcagct tttcatacag atgagcggga actagaacag gcaaagcagt 3627121 ttttacgcaa tgaattgctg ctgcaattcg attctcccga aggtctattg gcctatatgg 3627181 gggtcctgcg ccgcttctcc tgcacgaaag aagccttgct ggatggcatc tcagcggtta 3627241 catgccgtga tgtattgcaa ttcatagcga ccatcaatta tatcggagct catgtagtaa 3627301 ggggatgaag agatggaaaa gaaagccttt tttcaacagc tggatgaacg aaccgatatc 3627361 agatacacag acagcggact aaaaatattc agattgaaat tcccccgcgc ccacctgcgg 3627421 ctgtgcaatg taaaaatcga ttttggaagc cgggatgtat gtatacgggc agaatccggt 3627481 gatacactgc ttccgtatgg cacagcacat tttttagagc atcttctctt ctggcataac 3627541 ggccgcaatc tgtacagtga tttttttgcg catggcgcgc ttttaaacgc attcactacc 3627601 tacaccgata ccaatttcat gtttacctca ttaccggatc ggctcagaca aacgattccc 3627661 atcctgcttg atgctttatg gaaccactca tttgacaaga agattgtcgc tcaggaaaaa 3627721 gctgtgatta caagcgaaat tcaaacagca caccttaacc atcagctctc atatcattat 3627781 cagctgatca gcatgctttc tccctcctca ccagctgccg ttttccccgc aggcagaatc 3627841 gaagatattg aggcgctgga catcagtgat ttacaaaaag cctataaggc tgcctaccaa 3627901 gcccatcgga tgacgctgtt tttgattggg ggctcagaaa atacagaaac gcttttgcct 3627961 cctcacctcc agctggaaaa gcgtccggat tatcatgctg aaagaaaaat catcccggca 3628021 tgccctccag tcctctcaca aaaaatgatg ctgggtgatg aggagcggat ggaagatacc 3628081 tggaccggat tacagatcgg cgcacttccc gggcaaaacg atctgttgtc gataaagctt 3628141 tattgggata tcgcggctcg tattctattt caattagatt caccgttttt tcaagagatt 3628201 cagcaaacgt accgcctgga aatcgatcgc ttgtcagccg agacttatat atatgaggat 3628261 ggcggtttct tgatccttca cagtcaaggg acccattctt cagcttatat cgatgtggct 3628321 tcatactatg tcacacagaa gaaagaacag gttgccgcct ggcttcaata cggcaaggac 3628381 tctttgacag acgcgatcat ttatgacagc gattatgtgc gtaaatgctt cgagtgggca 3628441 gccgagtgtg acaggtgcga ttgctcgttt cttgacatgt accacatcat tcaagatatg 3628501 gatgcgcagg ttttcttgtc tctcattgat gcaatggcat cttctaacaa agcgatcatt 3628561 cacgtttctc agaaagaggc gatcagacaa tgaaacaaag cactgtcttt acccttttat 3628621 tgctgcttat aggtatggcg gcttattcct tcggctgggt tcaggccgtt gccgaagccg 3628681 ccgcccaata tgtacagatg atcaacaatg atgctgtgcg gctcggactg ctggcttgta 3628741 ccgctgccct cctgatgctg cctgcttttc tctatcttca ctatgtcacc caatccgtga 3628801 aaaacatgac agcagctttt cagaaactca cacagtctca tcaaagctgc tgtgactttc 3628861 agcaacacaa cttgtgcagc cgatatgcag aagacgtcaa atcgctgcgt gacagctata 3628921 aaaacgtccg ccaaacatac gtgatggctg ccgtgttgtg ccaagtcatc atattcggct 3628981 gcatgttcga aatcgttaaa gccgtccctt tccgccttca tacgccccct gccttttcaa 3629041 tgggacttgc gatgctactg atcctgtatt tattgttttg catgcgaacg tatttgcggc 3629101 agcttttccg gcacggcagc ctgttcagaa aagtgtttgc gggagcactg gcagcagccg 3629161 ggatttggtg gatgctcagt ttctctataa gtgaactgct gtttctgatt atcctggctg 3629221 ccattcagca aatcggatca tttatttata aacgattctc ttatcacagc accgcttctc 3629281 ttgatctata aaatagctac atcgcaatcg cagacggacc cgcgccaacc ggaatcaccg 3629341 tcacggctgt ataatcactt gtgcggtaca cggtcacagc attgtcgttg ggctgtgccg 3629401 cataaatata ctgtttgtcc ggcgttacgg cgaggtcaaa ggcgccgggg agagacacgt 3629461 ttgcaatgat cctctgtctg gccgtattaa ctacgtataa gttattaatg agaaacggtt 3629521 cactatatgg ctctagaaaa taagctctag tactatcgag agaaaataca atcgtcctca 3629581 gcgtttcaaa taaacggctg aagtcccctc ccctgcttaa tggtgacaaa ctaatctccg 3629641 ttacaccttt cggccacagc tcaccattca atacgtacgc aaaatttcca gcgtaaggag 3629701 ttgtaattaa actgggaaat tcaaatgtat ctatgatact ttctaccaac tgcccagtat 3629761 ttacatcata tttatcaacc gaccaactgc ttccattagc ggtatagaca tactgtccat 3629821 tcggatcaag agcaaagtct aaagcgccgg gtatcggaat gacatcaatg accgattgag 3629881 aggccgtgtt aatcacatat atagatccgg cggccatcac gtatgcgaac tcatctgttg 3629941 gatcaaattc gatttttctc ggccctcctc caacagtaat ggtatttatg atggttaatg 3630001 ttttattatc aatcactgag acaaggttgg tatttccatg gaggacatac gtgaatgctt 3630061 tatcgaaagt aacgcctaga ttagttggca cgtcagaaaa agggattgtt tttacaacag 3630121 tgtttaaatc tgcatcaata accgaaaccg tgctgtctcc agtattggca gtaaacacat 3630181 acgattgagg gtctggtgat ggcggtaaaa caagtgtccc ggccaccgta agcggactgc 3630241 cgtagaaagg cggtacaatg agcagatctt ccactgttat ttgactgaaa tcaggacagc 3630301 ggccagactg tgctgcataa taaacaactt gatcaatctc ttcagtatga atcacagaaa 3630361 cagccccgtc tccttgtcca tattgatttc gtacaggcga cacactgaca agaagcgtaa 3630421 tggtcccttg tactctcaca gcatatcgaa caccgatatc ttctggttcc ggcccagtct 3630481 ggattaagca aggctcactg atacaggaca aattgtctgt actccatgta acagccgctg 3630541 acgcttcggc cgtatcaacc ttgaagccct cagggaaatc tatcggcact tgaaacggcg 3630601 cttcccggct aatttcctca tcacaaaaac agaaacaatt ttcctgtaaa gcagaaagat 3630661 cattcttttt catgatttca cgtcctttta gaaatgcaca acatgcagcg gttaaatcgt 3630721 aatggcaccc ggtgaaaccc caagagatat cacagtttcc tcagaataat catctgtgtt 3630781 gtaaacaatg atgctctgct ctataaaacg agttgcatac agaaaatcgc cattcggggt 3630841 aaacgcatag tctgttgctg attgcggaac atttcctata acgcctgctc catttggact 3630901 gacagaatat aaattgccag tgaagccgtc atataaatac acctctgctc cactcgtaaa 3630961 cattcgatat tccccttcat actccagctc ttgggtgctg ctgatggtaa acgtatttaa 3631021 atcaataacc gtcaaataat taaaaaagaa ttcttgttct aatacatagg cataccgctc 3631081 cggccaattt gtttctatgg ttgatacgat aagctctcgt tcaattgttc ctgtgacttc 3631141 accggtagtt aggtccactt tttgcactat tccaaaattc agaacatagg cgaataaccc 3631201 attgggatcg attgcaacat catatccttc cacaggaatc gacctatcca cagttaacgt 3631261 atcaattcca atcacataaa ccgcagtacc ggtgaaaaca taagcaaact catgattagg 3631321 gataaatcta atcaatcgag gcggctgatc cagcaatata gttgctgtca ctgttaatgt 3631381 gtcataatcg atgacagaaa tcacattatt gttgggatgt aagacaaaca cagcgctttt 3631441 atctggcgta atttcaatac ctgccggatt gtacggaaga gcaatcgttg tcacaacagt 3631501 atcggtgttt gtatcaatca cagaaactga ttgatcattt ggattcgctg taaacgcgta 3631561 gacgggttcc ggctccggta caagcacaat tgtccccgtc accgataaag gactgccgta 3631621 aaacggcgga acaacaacaa ggttctcaat cgtgatgtca ctgatatccg ggcaatcatc 3631681 cgattcatcg gaataataga cgacttgatc gatttctgca ttgtgaatga cggaaacagc 3631741 cccgtcccct tgtccatatt gatttcggac aggtgagaca ctgacgagta gcgtaacggt 3631801 tccctgcagg cgcactgcaa attgaacacc gacctcatca ggctcaggcc ccgtttgaat 3631861 taagcaacgg tcactgacac aagaaaggct gtctgcattc cacgtcacgt ttgcaacagc 3631921 ttcagccgga tcaacgacaa acccttcagg taattcaatc ggtgcttgaa acatggcttc 3631981 tcggcttgct tctccctcac aaaaacataa gcactcttct tgttctgctc ctgctttttc 3632041 tttaaaggaa agcttgtttt ttctcattcc ttcacttcct tttcagacat acactgctca 3632101 cgcagatata acagaatatg gaagggtaac gtgtttgctt gtacaaattg ctgagggtaa 3632161 acgcttcttt ttgaaaatat atctccaaac atgcggtgta acgaaagaaa aaattgcggt 3632221 ttttttgcgc ttctcacaag aatgttgatg ataaaatatg acatatatag aattatgaag 3632281 ggagggattt gcaaacgtga caggtgtcat atcttcttct tccatcggag aaaagattaa 3632341 cgaatggtat atgtacatac gccgattcag catacccgat gcagaatatt tgcgacgaga 3632401 aatcaagcaa gagctggatc aaatggaaga agatcaagac cttcatttgt actattcact 3632461 gatggagttt cggcacaacc taatgcttga gtaccttgaa ccgttagaaa aaatgaggat 3632521 tgaggaacag ccgagactgt ctgatctgct gcttgagatt gataaaaaac aggctcgttt 3632581 aactggtctg cttgagtact attttaactt cttcagaggc atgtacgagc tggaccagcg 3632641 ggaatatctg tcggctatta aatttttcaa aaaggccgaa agcaagctga tattcgttaa 3632701 ggatcggata gagaaagctg agtttttctt taagatgtct gaatcttatt actatatgaa 3632761 acaaacgtat ttttcaatgg actatgcacg gcaagcatat gaaatataca aagaacatga 3632821 agcttataat ataagattgc tgcagtgtca ttctttattt gccaccaatt ttttagattt 3632881 aaaacagtat gaggatgcca tctcacattt tcaaaaagct tattctatgg cagaagctga 3632941 aaagcagccc caattaatgg ggagaacttt gtacaatatc gggctttgta aaaacagcca 3633001 aagccaatat gaggatgcca taccttattt caaaagagca atagctgttt ttgaagaatc 3633061 aaatattctt ccttccttac ctcaagcgta ttttttaatt acacagatcc attataaatt 3633121 aggaaaaata gataaagctc atgaatatca tagtaaggga atggcttatt cacaaaaggc 3633181 cggagatgta atatatttat cagagtttga atttttgaaa tctttatact tatcaggccc 3633241 ggatgaagaa gcaattcaag gattttttga ttttctcgaa agtaaaatgt tgtatgctga 3633301 tcttgaagat ttcgctattg atgtggcaaa atattatcat gaacgtaaaa attttcaaaa 3633361 agcttctgct tattttttga aggtggaaca agtaaggcaa cttattcaag gaggagtgag 3633421 tttgtatgaa attgaagtct aaactattac tctcttgtct ggctctaagc actgtgttcg 3633481 tggcaacaac tattgcaaat gcacctacac accaaattga agttgcacaa cgaggaatga 3633541 tttaaccgcc gtccatcggc ggttttttcg tcccctcttt accaaagtct cccaatccat 3633601 gctatgatct tttcaataat cttgaagaga gtggaaatgc agcatgtctc taaaaagtgt 3633661 gagaacccac tttactcaat ggaatcgaga aaatgatgtg acggagttcg aaacgtcgag 3633721 tgcgacagtt gaacaggcag ctgagacaat cggcgtaagc ctgtctagaa tcgccaagtc 3633781 cctgtccttc agaggggaag gagatcaggt gattctgatt gtggcagccg gcgatgccaa 3633841 gatcgacaac aaaaagtcca ggcaaacatt tggctttaaa gcaagaatgc tctctcctaa 3633901 tgaggtgctg gagcagacag gccatgaaat tggaggagtt tgcccatttg gattggctca 3633961 tgatcctgag gtttatcttg atgtatcgct gaaacggttt cagactgttt tccccgcatg 3634021 cggcagcaga aactccgcta ttgaattaac accgaaagaa ttatccgaat tttctttctc 3634081 aaaagtgtgg attgatgttt gtaaagactg ggaataaaaa aacatccaga catcgtctgg 3634141 atgtttactt atttcacaaa cccaagcagc atttcacgga tgattttgct ggctgtgttt 3634201 gccgtttgct ctgagtggtc gtataccggc gcgacttcca ctaaatcagc gccctttacg 3634261 tttacctctg aacgcgcaat ttcatggacc gatgcaagca gttctttaga cgtgatgccg 3634321 ccggcgtcaa ccgttcctgt acccggtgcg tgtgcagggt ctaatacgtc aatgtcaatt 3634381 gtgacataaa ccggacggcc cgccagcttc ggaagcacct ctttcagcgg ttcaagcact 3634441 tcaaattttg agatgtgcat gccgttttcc ttcgcccatt caaactcttc tttcatgccg 3634501 gaacggattc cgaatgaata cacattgtgc ggtccgatca attctgccgc cttacggatc 3634561 ggcgtggagt gagaaagcgg ttctccctca taatcaacac gaagatctgt atgtgcgtca 3634621 aaatggataa tcgcaaggtc tgggtatttc ttgtacatcg ctttaatgac aggccatgac 3634681 acgaggtgct ccccgcccat acccattggg aacttccctt tttctaaaat gctgtccacg 3634741 tactcttcaa tcatatccag gcttcgctgc ggatttccga acggcagcgg aatgtcgcca 3634801 gcgtcaaaga agttcaagtc agccagatcg cggtctaaat atgggctgta ttcctcaagg 3634861 ccgattgaca cctcacggat tctgcttgga ccaaagcgtg agcccgggcg atagctgact 3634921 gtccagtcca tcggcatgcc gtaaagaatg gcgtccgcct cttcccactc gggacggctc 3634981 gcgataaata cttttcctga ataagcttca tcaaatctca tctataatac cctcgctttc 3635041 ctgtaaaaaa gcgcaagatt cgctcctgcg ccataccttc attatttaat caggtcactc 3635101 acaaatttcg gcagaacaaa cgccgcttta tgaatatctt ttgtgtaata tttcgtctca 3635161 atatcgaaga aacggctgtc ttccactgca agcggatcat attttttcga gccaattgta 3635221 aatgtccaca aaccgcttgg atatgtcgga atgttcgccg tatacagctt cgtaatcggg 3635281 aagatttcct tcacgtcgcg ctgtacattt gtgattaatt ccggtgtaaa ccatgggttg 3635341 tccgtctgcg caacgaaaat accgtcttct ttcagcgctt ttgcgattcc tgcgtagaat 3635401 ccttttgtaa acaggtttac agccggtccg actggttcag tcgaatctac catgatgacg 3635461 tcatattgat tttcagattt tgcaatgtgc ataaatccgt catctacctg cacgtcaacg 3635521 cgcggatcat ccagtttgcc tgcgatagaa ggaaggaact ttttagagta ttcgataacc 3635581 ttgccgtcaa tatctacaag tgtcgctttt ttcacgcttg ggtgcttcag gatttctctg 3635641 ataacgccgc cgtcaccgcc gccgactacg agaacgtgct ccggatttgg gtgcgtgaat 3635701 aatgggacat gcgccaccat ttcgtgataa acgaattcgt ctttttcaga tgtcatcacc 3635761 atgccgtcca aaaaaagcat gttgccgaac tcttctgttt ccaccatttc taaatgctga 3635821 aactccgttt gttctgtatg taacgtcttg ttaaccttca tcgtaatgcc aaagtttttc 3635881 gtctgcttct ctgtgtacca aagttcgctc aattgtcatc tccctttcga ggctgtattc 3635941 atttattgta agcgtcttat cagcttttat tctcggttga aatctcattt tcacctaagg 3636001 aaaaagtata gaggatggcg gggaaaaagt aaagatgcgt cctgttctgc gatgtttaaa 3636061 aacgatcttt ttttctcata atagtagaaa cataaaaaaa gggggaaccc gttgtggatg 3636121 caatgacaaa taaacggctg agactgacgc tgaaaaccgt tcgcgccttt atctttttag 3636181 gggcttttgc ggccttggcg gcagctgctg tgtttatgac tgtcattttg atagccaaat 3636241 accagggcgc tccctcggtg caagtgccgc aatccacgat tttgtacgcg agtgacggct 3636301 caaagctcgg ggaaacgaac tacggcgaaa agcgctattg ggtcccctta aaggacatga 3636361 atccgacgat cgtaaaagcg acagtggcga ttgaagacca gaatttctac gatcatcacg 3636421 gctttgatta taaacgcatg gccggcgcgg cgcttgctga cctgaaagca tttgccaagg 3636481 ttcagggtgc aagcaccatc acccagcaat atgcgagaaa cttatacctt gaacacgaca 3636541 aaacgtggaa acggaaatgg aatgaggcgt tctacacgat ccgtctggaa caaaactatt 3636601 ctaaggacga gatattagaa ggctatttaa atacgattta ctacggccac ggcgcctacg 3636661 gcattgaagc agcttcccgc ctgtatttcg gcaagcatgc caaaaacctg acggatgcgg 3636721 aggcggcgct tttggcagga atcccgaaag gcccttccgg ctattcaccg tatgtcaatg 3636781 agacgaaggc caaggaacgc cagaaaacga ttgtgcggat gatggaaaag cagcagatga 3636841 tcagccaaaa gaaagcggat gaattgatca aggaacctct ttcctatcag cctttgaata 3636901 aacaagtttc caagagaaag gctccttatt tctacgacaa tgcgatgaga gagctggaaa 3636961 aaaagctcgg catgacacgg gagcaaattg aaacgagcgg gttaaacgtc tatacaacgg 3637021 tagataaacg gatgcagcgc atcgccgagg agaccattac cgaaacggtt aacgcgggct 3637081 ctgacattca agtcgggttt tcagccattg atccccgcac cggaaacgtt ctcgcccttg 3637141 tcggcggcag ggattatcaa aaaagcccgt ttgaccggac gacacaggcg aagcgccagc 3637201 ctgcttcgac gatcaagccg ttgctgtact ataaagcgat tcagagcgga tttacgccag 3637261 tcactttgat gaaaagcgaa gaaaccgagt ttcaaattga tgcaaaggga gaaacctatt 3637321 ctccaagcaa ctataacgga tactatgcca acaagccgat tacgcttctg caggcgctgg 3637381 cgctttccga caatatttac gctgtgaaaa cgcatctttt tctcggcacg aacaaacttg 3637441 taaagacggc aaaggaattc ggcattaccg cccatcttca agcactgccg tccctggcac 3637501 tcggcaccga acccgtacgt ccgattgaga tggtcaacgc ctatgccatg ctcgcaaatg 3637561 gcggaaagaa aatcgaaccg acttttattt caagagtaac ggacgcagcc ggccacgtgc 3637621 tgtacgaaaa cccgaatcag cataaacagg tgcttgatga aaaagccgct tttgtcacag 3637681 cgagtatgat gacaggcatg tttgatatcg atttaaatgg atatacgtcg gttacggggc 3637741 gaacgatagc caaccgcctg acaagaacgt atgccggaaa atcaggaacc accagcgcag 3637801 acagctggat gatcggcttc aatccgaagc tggccgccgg tgtttggacc ggctatgaca 3637861 aaaacagcac catcgactcg gtcgaagaaa aaagctatgc taaaaccatt tgggcggact 3637921 tcatggagga cgcgctcaaa ggcgaaccgg aaaccgcgtt caagccgcca aaaggcgtaa 3637981 ccggtgtgta cattgatccg gaaacaggct actcatcagg tcccggctgc gccgctaagc 3638041 attacacata ttttgtgaaa gggacagaac ccgcaaacgt gtgctacggg gcagaacccg 3638101 caaaacaaac aaaagaccgg cttccatcca aagaaaagcc cgcttccgag aaaaagtggt 3638161 gggacaaatg gctggggcga catcattgaa aataacccgg ctcctcggag gccgggttat 3638221 tcgtatggtt ccttcataat cgatggaaga atgttagaca atcgagctga acaatcagtt 3638281 ttgggataaa gtggtgaatt tctcatttct tcggcgctgg ctttcatctc ccagtcgccg 3638341 actcatatcc ccctaaaaat gaaaaacccc gagtcttgtt tcggctcggg attttccatg 3638401 tcctatttct gtatcaccag tttactcaat gtttacgaaa aatatctcaa atactttaaa 3638461 agttcacaaa aaattcataa attaattgtt ttctggaagc aggctcgttt ttaactcatc 3638521 tgaggaacgg tcccataggc cctgatcatg ctttttcaga aattcgccta gtacacgctt 3638581 cgagctgtcg tccattttat caacgatgat tttccgtttc atggatttat ccatcagatt 3638641 cacatgctca ggcagtgact tgtagcctct tctgatgctt ctgtcgaccg tcatttcaca 3638701 ggctgtcaca ccagcgtaat aaggcccctc ttcttttctg tcaatcgtta cccacacaag 3638761 ccagtatggt tttccgttcg gcacttcttc tttattcggg agaaatttaa ttcctttttc 3638821 aacggtgctg cgggcatgca tagcgccgat gtctacgaac gcttcttttt cctctacatc 3638881 aacgaatacg ggagaaatgt tatcaaggct gagtgcccct acgccaaaac cgccgtgtcc 3638941 gtctgtcgga tcacttttga taatattaaa cccgattgat tttttctttt tttcttccat 3639001 gaagttctac ctcctacaaa agcggttgaa atatcgctga aaacagcttt aaaatcgaat 3639061 ctcttcctgc attgagcatc ggccacagca cgtaagatcc tagcggtgtc acaaacagca 3639121 ccaaaaatac gataaagccg tagctctccg cctgcgtcat tttggcacgc acgcccggcg 3639181 gaacgagatc ttctataatt cgatagccat cgagcggagg aagcggcagc agattaaata 3639241 aaaacaagac aagattcagc tgtatccaaa tagaaaaaaa ctgatccagc cccgtgctga 3639301 acgccgcaag catttccatt ccgtacgcat gcatcaacac taacaaaaag aaaccaataa 3639361 acgcaagaat caggttactg acgggcccgg ctatagatac gagcacacca gcaagccggg 3639421 gtttcttaaa gaaacggcga ttcacgggaa tggggcgcgc ccacccgaat ccggccacca 3639481 gaatcaaaat ggttccgaac ggatcaaggt gtttaatggg attcagcgtc agtcttcctt 3639541 gttttttcgc cgtatcgtca ccgaatttgt atgcgacata agcgtgggca agctcgtgca 3639601 tcgtaaacga cacaattagc gtgatgacga ggtatggcat taaagataac ggataatata 3639661 aaaaacggtc caagtgagat atccctcttt ctcaaaatgc aagaatttac tttattcagt 3639721 atactataag aagcctcttt ttctaaagag aggaaacgag ataaaggagg attcagcacc 3639781 catgccatac gtaactgtca aaatgctcga aggccgtaca gacgagcaaa aacgcaatct 3639841 tgtcgagaaa gtaacagaag ccgtaaagga aacaaccggt gcttctgaag aaaaaattgt 3639901 tgtctttata gaagaaatga gaaaagacca ttatgccgtc gcaggcaaac gcctgagcga 3639961 tatggaataa tctctataaa gccggcgctt cgcgcaccgg cttttattat ccctattgag 3640021 ccagcttcgc aataatcgcc aagaacgtct ttttctcttc ggctgttaaa cgttcaaaca 3640081 tgccatcaat cagctgctgg cggttttcga tcatttgttc agccgctccc cggcccgatt 3640141 cagaaagagt aatccataca gtgcggcggt cattgttatt tctggatctc tcaataaacc 3640201 cttcctgctc taaatgattc agagctgtgg tcgtggcaga gggagacagt gtgacctcct 3640261 tcaaaatatc ctttatggtg cagctcccat gtctgtatat gatccgcaga ataaaccctc 3640321 ttacattatt cacgtgtttc ggaacggtgg cttcatctaa ttgcttcgtg cttttcaaat 3640381 actttgtaag tgcgtgatcc agcaaatttg cttccagttt gtcatggtcc atgtcaattt 3640441 ccccatttcg agatgcattc ataacatacg aacgatatga tttacttatt attttactga 3640501 ttccgaatag ggaaagtcaa aaaagcaaaa tgtgaattca cagcttttat cctacatgcc 3640561 tcgattttcc acctgtttca caagtttatc tttaaaagtt tggaaaggaa cgtgttcatt 3640621 ctgctgatgt ccgaatcggc ggacgtttac cgcattctcc tgctcctcat gatctccaag 3640681 caccagcacg tacggaattt tttgcacctg cgattctctg attttatagc cgagcttctc 3640741 attgcgctca tcaatgccgg ctcttatccc cgcctgcttc agctccgcct gcacttttct 3640801 gcaatagtct aagtgaacgt gcgaaaccgg tatgatttga acctggatcg gtgcgagcca 3640861 gactggaaaa gccccaccgt aatgctcgat caaaatgccg aagaaacggt cgattgagcc 3640921 gaaaaccgct ctgtggatga caacgggacg aaccttctca ttgagttcgt tgatatatgt 3640981 taaatcaaat ttttccggca tttgaaaatc aagctgaatt gtcgcgcatt ggtggctccg 3641041 tttcagggca tcttttatat ggaaatcaat tttcggcccg taaaacgccc catcgccttc 3641101 attgatctca taagagaggc caagctcctc aaggacgcgt gctaaggcac gttccgacgc 3641161 ttcccaaagg ctgtcatcgc ctaatgaatc ctccgggcga gtcgaaagct caacagaata 3641221 ctcgaaacca aatgtccgat atacctcatc aatcagccga atcgcttctt tgatctcact 3641281 ctcaatctga tcctcccgaa cgaaaatatg ggcgtcatcc tgacagaacg tccgaacgcg 3641341 aagcattccg tttaaagcgc cgctgtattc atggcggtgc acctgtccga attccgccat 3641401 gcgaatcggc agatcccgat aagaatacag gctgttttta aagatgagca tgtggccggg 3641461 gcaattcatc ggcttcattg cgaatcttgt atcatccact tctgaaaagt acatattgtc 3641521 gcgataatgg tcccaatggc ctgactgctc ccataaccgc tgattcatca taaacggcgt 3641581 acgcacctca tcgtagccgg catttgtttg cagctcacgc gagaagcgct ccagctcatt 3641641 gcggacaatc tgccctttcg gcaaataaaa cggcatcccc ggcgcttctt cagaaaacat 3641701 aaacagccct aactgtttgc cgagcttgcg atggtctcgt tttgccgctt cttctagcat 3641761 atgcaggtgc gcatccaaat cttttttctt ttgaaacgca accccgtaca cccgctgcag 3641821 gacttcattt ttgctgtctc cgcgccaata agcgcctgat actcttgtca gtttgaacgc 3641881 cttgatcatc cctgtagaag gaagatgcgg ccctcggcac aggtcaacga attccccttg 3641941 ctggtacagt gtgatatcct ccccgcgcgg aatatccttt aaaatctcaa gcttgagccg 3642001 ctcgtctttt tgtgcaaaca gctcttcagc ttcttcgtaa gaaacctcta tacgtttgat 3642061 ttcaaggttc tcatttatta tgtttttcat ttctttttcg atggcctcta agtctcctga 3642121 tgccaagctt ttccccagct tcatgtcata gtagaagccg tctaaaatca caggccctac 3642181 ccccaatgac acttcgccgt acagccgttt tactgcttgg gccagcacgt gcgctgttgt 3642241 gtggcgaagc acctgcaagc cttcttgtga atcgagtgtg acaatcgaaa gctcagcatc 3642301 ctcctccagc ttgaaactga gatcaacaag cttgccgttg acctgacctg cggccgcctt 3642361 cttttgcaga ctggaactga tcgaaccagc cgcttctttg attgtgatgc ctttcggata 3642421 ttcctggatc tgtccgtccg gaagctgaat gtgtacatgt ttgctcattt tagaacactc 3642481 cttattcatt gttgtatata aaaaaacaca cccgtcccgc agatagggac gagtgtgtga 3642541 ttaacccgtg gttccaccca agttcccgac aaatactatg ttgtcggctc ggtgctgtaa 3642601 cgcagcatag acggcattgg ttacttcagt tccccaatgc tgctccaagg cggtaaatga 3642661 tattcctaag ctgggaagct ctcacctttc cttccctctc tgaaaaccgt aactatcatt 3642721 catgtccttt tcatcgcatg tattcaattc ataaaaaaac acacccgtcc cacagatagg 3642781 gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact atgttgtcgg 3642841 ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa tgctgctcca 3642901 aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct ctctgaaaac 3642961 cgtaactatc attcatgtcc ttttcttcgc atgtattcaa ttcaaataaa aaaacacacc 3643021 catccctcta aaagggacga atgtgttgat catccgtggt tccacccaaa ttcccgatca 3643081 attacacatg atgatcggct taaagatgct gtaacgcagc atgacggtat cagatacttg 3643141 ttttccctga tacggctcaa aggcggtaag ctgctttccc tgcgttagga agatctcagc 3643201 tgtccttccc tctctggaaa ccgtaaaaag catctcgtgt ccttatcagt gcctgttgtt 3643261 tcaataattt tttatatctt actatatatt cccacaaagc gcaatcagtg atttacattt 3643321 tttctgacgc ggcagtcccg ttatgggcag ccagaaacag ccatacaagc aatgcagcga 3643381 ggctgtatgc cgctcccatc atcaaaaacg caaacccggc accagcatac caagtggcgg 3643441 acagatgaat gatcaccccg gttatcgcta cgccgaccaa ggctccgatt tgccggtttg 3643501 catttaacgc cgcaccggcg atattcgtat gtctttgccc ggcagcctgc atgatcacag 3643561 ttgtcatggc aggaactgta ataccggtac agaggttcat aacagacatc aacaccgcca 3643621 gctgccaata aggaaaatcc ggagaaatca gcacaaacaa cagcaatgca atgatacagc 3643681 tgaccgccat tgatacaaac ataagctgac cggcttcaaa ccgattcgcc agacgggcaa 3643741 acagcagatt gccgatcacg aagaccgcca tcatcggcag cagctccact ccagccataa 3643801 aggaacttgc ccctcctgct tcctgcaaaa aaaggctgag cataaacatg ccgccaaaaa 3643861 gggcgaaatt cagcaaaaac ccgataaatt gggcagctga gaagcggccg tttttgtata 3643921 aggacgccgg caggatgggt gtttttgcag aaatttcccg cagcaaaaac agcacaaatg 3643981 ccaaaaccgc tgcagtaaat gctacaagaa tcactggcga gcgccagccc gctgaaggcc 3644041 cctgtatcaa agcataggaa agaaacccga gagccatcat gccaagcaga tgcccgatga 3644101 tgttcacgcg gctgcttttc ccaggaacgc ggctgaggat tcggtaagct gaaatgagcg 3644161 cagcagcccc tattggcaca ttgatcagaa aaatactctg ccagcccgcc aactgtacca 3644221 gcacgccccc gataaaaggc ccaagggctg aagcggcgga aacaagcgcg gcccacagtc 3644281 caaacattct cgcccgcgcc cgctcatcaa ggtaagaggc agccaaaagg ctgagtgagc 3644341 ttggcataaa caaagctgcc ccaattccct gtatgagacg tccggcaatc agcatctgcc 3644401 catttataga tgcagcgcat agacaggagg ccataacaaa aacggctaga cccaagatat 3644461 agatcgtctt cgagccgaaa cggtcagcca aggctccgcc cgccagcaga agcgacgcaa 3644521 aagtaagaat gtacccgtcc acaacccacg ttacacctga aagtgacatt gaaagagtgt 3644581 ttttcatatc agccatcgcc acattcacaa cggtcacatc aagagttgcc atgaggaaac 3644641 caagtgcgag cacgatcagc acggatatgc ctgttgatga tgttgattct tgtatagacc 3644701 cgctattttt cattacaatt gccctttcac ttgcttgatt acccaatcat ctattttttc 3644761 aagatcatac aattccccga ctctgtccat aacatgctgc aaggattctt ctctcataag 3644821 attggaccat ttatcctcga tttccgccat gactgtctcc agcacacagt gactttcacc 3644881 ctcaaataca gattgcagca agcctttccc ctgatacatc gaacctctgc cttcgaccgc 3644941 ttgataaaca tcataaagcg taatgtcagc caaaggcttc gtcagggtaa aaccgccctt 3645001 cgtccctggt aaggattctg ccaaaccggc ttgaaccaat gttctcatca gcttcttcaa 3645061 gtaagacgga gacacgcgca atcgctggct tatagcctct gacgtcaaag aagcctgtac 3645121 cggcagccgt gacagtaaca gcagcacaga aaccgcctgc tccattcctg atttcatttt 3645181 catcctattc actcctgatt cattatggat aactattatc cataatgaat ctcttagcag 3645241 cttttgtcaa taaaaaaagc aaaagaaacg gatcatttct tttgcttggt atggttaaca 3645301 aatctgcttc agttcctcta tgtattgaag cgcttcgtca tattcttcat ttgtatattt 3645361 ttgcttgctt ttgatggtaa agactttttc tttcttttcc tcatcctcaa gcccgtcaaa 3645421 gtaaaggatc gtggaaacca gctctaaaaa ccgtgatgaa cggctgttta cactgtcgat 3645481 atagcctttc atatccggca tgtccagatc agcatggtct aaaaatgcgg agcctgtctc 3645541 agtcagcgaa taccggtatt gaaagtagcc gccctttttt tccttcacct catgcagaaa 3645601 tccaaggttg cacagctctt caatctggag cgtcagttcc tctgaatatg gtccgtaaaa 3645661 gtgaaaatca tatttctcat agaaaggaaa ctgcattttc ttggcgatat aaatcatttt 3645721 ctgcagcttc tttcgcccga tgatttctcc agaatccgag aacaccttca tcagttttgc 3645781 atgttctttc aacaaattcc cgacatctcc tttttccttc tttccaattt ctatgtcagt 3645841 cccagcagct gccggatttt cattttcgct tccggatgtt tagtgccgtc acaaatcaag 3645901 tcctttggat agtacagctt gtggtccgtc cgccgtttac ctgagatgga ttccacaata 3645961 gccgactgtc tggacagctc tttaatttgg ccgttttgcg tcaagagatg gatcggcaga 3646021 cgctcctctt cctctcctgg tcggtaaaaa tcgtatggca gatctgatga agaatcaacg 3646081 accaaataat agctcggatc gatccccgcc tctttgaaca atgaagtcag ctcaaaataa 3646141 gccgacattt cttcattcgg attgaattca acgtattgga aaagctggcg gttaatgaat 3646201 ctgcggcaca agtcggataa aatcgcgtct tcttcatcct cccaggcctg gaagtaatac 3646261 aaaataatag attcatccag ctttacataa tcctccagtg tcaattttcc ttcaaaaata 3646321 gaatagaaat gaaccggagc gtgagtgaag acatagcctt catcgtgcag ctgcttcgcc 3646381 ctgtgaagaa tcttcgttaa aatgacctct gcacttctag tcacaggatg gaagtagacc 3646441 tgccagtaca tttggtaacg gctcatgata tagtcttcga cagcgtgcat tccgctttct 3646501 ttaatgacga tctgatcctc gcgcggccgc atcacccgaa gaatccgctc catatcaaaa 3646561 tggccgtagc tgacgcccgt ataatatgcg tcgcgctgga ggtaatccat gcggtctgcg 3646621 tcaatctgac tcgaaatcag gctgaccact tgcttgtttt tatatgtttt ggcaatgact 3646681 tcagcaacat cctgagggaa acccgggctc acctttctga gcacctgatt aacctccgtg 3646741 tctcccaaaa tgatacctct tgtaaaatcc tcgtggtcaa ggtgaaagac cttttcaaat 3646801 gaatgcgaga acggcccgtg cccgaggtca tgaagcagcg ccgcggccaa acagagttcg 3646861 cgctcactgt catcccattc agggcggcct ttaaagacgt catcaaccat tcttctgaca 3646921 atttcataga caccgagaga atggttgaac cggctgtgct cagccccatg gaacgtcaaa 3646981 taggtcgttc cgagctgctt aattctgcgg agacgctgaa attcacgggt tccgatcaaa 3647041 tcccatatca gcttgtcccg aacatgaaca tagcggtgca ccggatcttt aaacactttt 3647101 tcttctgata attttccatt tggatacgcc atcgtcattc cctctttttt ttagccgtgt 3647161 ttctattata tcgactctat tctttgaaaa catccttgaa tttgcccggc gatttgttcc 3647221 atcttcatga aaaacacatc ttgtgaagca aaaaagcctg acctgagggc cgaggctaag 3647281 aaaaaatatg tttttacttt tttattttct tttttacttt gtcaatcagc tcatcctctg 3647341 tcggagctga cagcgggcga ttgttcacaa aagcaaatga ttttttccgt ccgggcccgc 3647401 aataagattg gcatcctacc tcaacctttg cgtccgggtc cacttctttc aaacgcggca 3647461 gcaatgtttt gatattagtg gcttggcaat catcacacac tcgaaattca ttagccatga 3647521 cgtacgcttc ccttcatttc tatgttcatc tatgtgaata acctaaaatc acgtttcaaa 3647581 aaaaatcaca tcacacttca ttttacaagg attcgactgt tcctgcaagc cgctccatcc 3647641 ttcgtatctc ctattctttc agccaatttg tataaatatt ttccaacctg gacattctaa 3647701 taccatgaaa agaaaaatgg gagttgagat aaatgacaaa acagcgacaa gacgcttggt 3647761 cagaggaaaa cgatctgctt ttagccgaaa cagtgcttcg gcatgtgagg gagggcagca 3647821 ctcagctgaa cgcctttgaa gaagtcggcg ataaattaaa ccggacatcc gcagcctgcg 3647881 gattcagatg gaacgcagtg gtccgccatc aatatgaaaa agcgcttcag cttgcgaaga 3647941 aacaacgaaa acagcggatg agagcgctcg gaaacgggca gcccgcgaaa aaaagattat 3648001 tatatcagcc tcctgccgtt gatcctgaaa tcattcaaga aaccgctgca gaagagccgg 3648061 ttaaaacgga aacaccatct gtcgaaaatg agcaaccttt aatgtctggc gaacacatgc 3648121 cttttgttga tgaaagcttt aaggaagagt tagctagtct atcacactta ttgtctcctc 3648181 aaacgcctgc agctgcgcct gagatgacga tgaatgatgt gatccgcttc ctgcagaatt 3648241 acgaaggcaa tcacgagcaa tcatcagcat taaaaatgga aaacgagcgt ttaaagaaag 3648301 aaaatcagga attgcaaaac aaaacagagc agctagaggc agaagttcaa aagcttgaaa 3648361 aagaccaaaa aacgatccaa gaagattatg aaaccttggt gaaaattatg aacagagcca 3648421 gaaagctagt tttatttgaa gaagatgaac atgcctctcc gtccttcaaa atggaccgga 3648481 acggcaattt agaaaaatta gcggaatgac atagaaaaat cccaaaacgg gcagctgttt 3648541 tgggattttc gccatgtgca aaatcccctt ttctattgag aaaagagaat ttcctcattt 3648601 tgcagccgga tcagctattc ttgtaaaatg aggccaagct tatgtgaatc tattaagaca 3648661 tgtgagctgc ctcggccgtt ttttgtttcc gaggcgcagc agaaatgacc aaaagcccca 3648721 gcatcataag cgcaatgccc agccacgagg aaggcgaaag catttcccct atgaaaaaca 3648781 cgccaagcaa tgaagccgtc agcggttcag ctaaagacag cgtgaccgcc gccgaggccg 3648841 gaaccccggt aagccctttc gcaaacaaaa agtatgcggc acatgttgca attaacccga 3648901 tgtaaaggct tgttcccagt cctctagggg tcaatatcca cgagatatct aactgccata 3648961 atagcggcgt cagcaagatg gcgctgatca tgaatacaac ggcggaggtc gctcgcggag 3649021 gctgggtttt catcatcgct ttactgatga gcgtatagcc tgcaaaagaa gcacccgctc 3649081 caagcgccat aagaacacca gccacatcaa tccgaacatt ggaactgtcg gaaaacagaa 3649141 gccagcaacc cgctaaagcc agcacagtcg caatccacca ggagtttcgc gggcgtttct 3649201 tcaatacagc ccattcgagg gtcccggcaa tgataggcgc actgccgatg gcaatcacag 3649261 ttcccactgc aattcccgtt tctttaaccg ctgtgaaaaa cagcggctgg taacacgcca 3649321 tacaaacagc ggctaaaaat acgagcggcc atgcccaatt tttcacgtga agctcccggc 3649381 tgatccaaac cgcaagcagc atggcgcttc ctcctattaa taacctgaac gctccaaatg 3649441 ccagcggtgt ggcgctttct ggagccaatg cctgaacggt tcccgtggtc ccccagaaaa 3649501 aagccgcaat caatacaaaa aggctgtaaa tattcccctt catctgcctc tcccctttaa 3649561 tatggatgct gatgtcattt tatcgttttt ctttttgtcg tggttatctg tatgtaagaa 3649621 ggacttatct gaaaataaga ttattgaggt aaaatgccgc ttgagataaa aaatgcatgc 3649681 cggcatatac agccggcatg cgaagaacgt tcacccaaat acctttgcat tccgctcagc 3649741 catccggacg aggtttttct caaattccat ttcctcatca atggacagtc cagctgaata 3649801 aagatgggtg cttaacgctt ttaattccgt caataaagcg aacattaagt cttgtacgga 3649861 gatgtctttt tgaagaagct cacttaagga cgccatcgtt tccggacgta tttccggata 3649921 gacgcctttt ttatcgtttt gtttgtcttt cagcgccgct tgatagaatc gtctgatcaa 3649981 gtcggccctt tcactgccgc ttttatctgc acagagataa atttgaacag cgactccgcc 3650041 gcgaacgcgt ctctgagaga tgccggcgaa ctttttgcca tttatactga ggtcatagct 3650101 gccgggacaa taagaccctt caatttcata ggcttcgatc tttgcgttgt acggtctcag 3650161 cattcgtctc atcagctcga ccatcgcttc atatcctttg tctatatcga tgcctttctt 3650221 ttcgtcctcg aatatgagag agatatttaa aacaccgtca tccaatacga cggcaagacc 3650281 gccggaattg cgtacgatca cacggtatcc ttcgctctcc agcaaggaga taccatcctg 3650341 caaaaacggg aggcgtgtat cctgtattcc aaggacaatt gtatcgtggt gcacccatga 3650401 gcgcgctgtc gccggcgaca cgccttttcc gacggacatg catagcgtat catccattgc 3650461 gaaggattgc ttcgcatcaa ataaagggcc gagactggat tggtcaatga ctctccattt 3650521 cggctgcatc agtaaatcaa tcggttggtt tgccatctat gtaaaaccct ttcatgttag 3650581 gcttattgaa cgaaaactat tatatcattt cagcagctgt gattgataat tgcttttcag 3650641 catcgtaata aaaatttctt tattttttgt attctccatg agaggagaat gaatgtaaga 3650701 cagcttgcgc tttaacgaga aattattaat atgcagaatt gaaatttcgc ggtggatcaa 3650761 atccttacgc agcacgcttc tggatagaac cgaaagtccc atgccgttaa tcaccgcttc 3650821 ctttacacct tgattgctgc tgatggtaaa cattgatttc ggccgaagtc catttgaact 3650881 gagtacatga tcgagatatt ctctcgtccc ggagcctttc tctcttgtca cccacgcttc 3650941 gttctgcaaa tcgctgatcg aaatctcttt ccgcccggcg agcggatgct gatttggagc 3651001 ggcaatgcac atttcatcct ccatgaacgg ttcaatttcc agctcattct cgtttgtatg 3651061 tccttcaatc agcccgatat cagcctgaag catccgcaca cgctcgctga cctcctctgt 3651121 attgccaatc atgacatcta gattcagctc tggatacagc ttttgcagct gggccaatag 3651181 cggcggaaga atatactcac cgattgtaaa gcttgcagct attttcaatt cacccttcac 3651241 atagtgatga tgcgcataga tttcagcctt ggcttgttcg tagagaaaca ccatttgctt 3651301 tgctctttga tataaaatgt ctcctgtcgg cgttgtcgta aagtgttttg gcgacctgtt 3651361 cagaagagcc gtttgaaatt ctttctcaag atttttgata tgcagactga cgctgggctg 3651421 ggagatcatc agcttttccg ccgcttttgt gaagtttttt tcttctacca ccgctataaa 3651481 cgttttcagc acgtcgtaat acaaaaaccc cacccctgtc attaatgaaa tatatggtta 3651541 tgattagttt tctttattgt actcatatca tccgtcttgg taaagaaggg ctatacagaa 3651601 gcgcaaaaaa ggcagccctc ggtcgagagc tgccattgtc ttcaatttta ttacagtgct 3651661 tgcgccgctg taattaatgc gagattgtaa acatcttcag cgttacatcc tcttgaaagg 3651721 tcgtttacag gcatatttaa accttgcagg attggtccta ccgcttcaaa gttgcccaaa 3651781 cgctgagcga ttttatagcc gatgtttcct gcttcaagac ttgggaatac gaatacgtta 3651841 gcgtcccctt tgatctcgga atccggcgct tttttctcag ctacagatgg aacaaatgca 3651901 gcatcaaatt ggaattcgcc gtcaagtgtc agttcaggcg ctttttcttt cgcgattttc 3651961 actgcatccg ctactttttc tgtttcatca gattttgctg agccttttgt agagaagctg 3652021 agcattgcca cgcgaggctc aatgtcgaac atttttgccg tattggcact ttcgatcgca 3652081 atctcggcaa gatcttggct gtcaggtgca atgttgatcg cgcaatctgc gaatacgtat 3652141 tgctcttctc cgcgagccat gatgaacacg cctgaagtct ttttcacgcc ttcttttgtt 3652201 ttgatgattt gaagagccgg gcggacagtg tcagcagttg agtgagcagc tccgcttaca 3652261 agtccgtctg caagtccttt atacaccagc attgtaccga agtagttctc gtctaataat 3652321 gctttacgag cctgttcttc agtcgctttg cctttgcggc gttctacgaa tgcttgtaca 3652381 aggtcttcca tgccttcata tgtatgagga tcataaatct taacgccgcc cagcgtaagg 3652441 ttcaattctt ttgcttttgc ttggatctca ttttcattgc cgatcacaat cggattcagc 3652501 actttgtttc ctgcaagctt gctgaccgct tctaaaatac gctcgtctaa gccttcagga 3652561 aatacaattt taacgtcttt tccagctact ttttcttgca ctgttgaaaa taaatctgcc 3652621 acaataaaac ctcctcaaaa agttacaaaa acgctttctt ttactagcat actcttcttc 3652681 caatcaaatt caaacagcca actttcatta tagcgctttc ataaaaaaat cttatttttc 3652741 taactaattt aagtgactca atcttccctt ataggttctt ctattttgat ggagttatac 3652801 ggaagggatg ttcaaggttt ctccacagta gaatcggata aactatggta tagtgaaggc 3652861 aatcatgaaa agataatggg agtgaagata aatgagtgaa cagcaaatga cgaatgaagc 3652921 ggcaaaaacg cttgacggct ggtatgcgct tcatgatttc cgcacaatgg attgggcttc 3652981 ctggaagctt ctgtccagtg atgagcgcca atctatcata catgaattca ccgggttgct 3653041 tgaaaaatgg ggcgtagccc aaaaagaagg aaaaggatcg caaactcttt acagcatcgt 3653101 cggccaaaaa gctgatttta tgctgatgat ccttcgtcct acaatggaag aattaaatca 3653161 aattgagctt gaattcaaca aatcaagact tgctgagttc accattccgg catactccta 3653221 cgtatcagtg gtagagctga gcaactactt ggcaagcggt gacggcgatc cttatgaaaa 3653281 tccgcatgtg cgcgctcgcc tttaccctga actgccggaa tctaaatatg tatgcttcta 3653341 tccaatggat aaaagaagat ctggcaacga caactggtat atgctttcaa tggaagaacg 3653401 cagaaacttg atgagaagcc acggtttaat cggccgcagc tatgcgggca aagtcaaaca 3653461 gatcatcacc ggctctgtcg gctttgacga ttacgagtgg ggcgttacat tatttagcga 3653521 tgatgtcctt caattcaaga agctagtgta cgaaatgcgt tttgacgaag tcagcgctcg 3653581 ctatggcgaa tttggttcat tctttgtcgg caatcacctt tcgcttgata cacttcctca 3653641 attcttatat gtataatatc ccctcccgcc ctatccggcg ggagtttttc aattctcctt 3653701 tatcagaatt taaataaaat ttgctatttt cttcgttttt tcttacgatg tagataataa 3653761 tccatttttt tcaaaggggt gcagttattt gtcaaaacga accgcatttg ttatgggagc 3653821 cagtcaaggg atcgggaaag caatcgctct gaaattagca gaccagcact tttccctcgt 3653881 cattaattcg cgaaatttgg ataatattga atctgtcaaa gaagacattt tggccaagca 3653941 tcctgaggcg agcgtcattg tccttgcggg cgatatgtct gaccagcata cgagagcggg 3654001 catttttcag aaaatcgaat ctcaatgcgg acggcttgat gttctgatta ataatatccc 3654061 gggcggcgcg cctgacacat ttgataactg caatatagag gatatgacgg ccacgttcac 3654121 tcaaaagacc gttgcctata ttgacgcaat caagcgtgct tcctcactga tgaaacaaaa 3654181 cgagtttggc agaatcatca acattgtcgg aaatctgtgg aaagaacccg gcgccaacat 3654241 gttcacaaac agtatgatga atgccgcttt aattaacgcc agtaaaaata tttccatcca 3654301 gcttgctcct cacaacatta ctgtcaactg tctgaatcct ggttttatcg ctacagaccg 3654361 ttatcatcaa tttgtggaaa atgtgatgaa aaagaacagc atatccaaac agaaagcaga 3654421 agaacagatt gcttccggga ttccgatgaa acgggtcgga tcagccgaag aaaccgcagc 3654481 gctcgccgca tttcttgcct ctgaggaagc ctcctacatc acgggacagc aaatttccgc 3654541 tgacggcggc agcatgaaaa gcatataaaa acatcccgct ttttagcggg atgtttcttg 3654601 taatgacccg aacggcaggt tcagcttttg aatccgcgtg acaaattccc gcagatcctc 3654661 ctgcttcgac accattgaga ttctgacatg cctttttccg ttgcttccaa aaatttcgcc 3654721 cggtgtgact acgacatggg catgctccag caagtaatcg gaaaattggt gagatgtctc 3654781 aaacgtattc ggaatttcag cccatacgta aaaggttcct tttggctttt ccatcttcca 3654841 gcccagttcc ttttcacaaa gcgccgtaaa aaagtcaatt cgttccttat aaattcgttt 3654901 caacgattcc gtatgctccg gatctccaga aagcgccgca ctcgctgcct gctgcagccc 3654961 gccgaacatg ccgacaaata catgatcctg aaattcattg acggcctgaa tgattttttc 3655021 gttcccaacc gcaaacgcca ttctccagcc ggccatgtta aatgtttttg aaaatgaata 3655081 aagctctgct ccgacagttt tggcatcctc tgcctcaaga aagctggccg gtttttgatc 3655141 gaattcaaac gccccgtatg caaaatcatg aatcaaatgg atgttatgct ctttcgcaaa 3655201 agcagcagct tttgcataaa aagccgcatc agccacagct ccagtggggt tgttcggata 3655261 gtttaaaaac ataagcttcg ctttttccag cacggctgga tcaatctttt caaaatccgg 3655321 cagatagcca ttttcttcat acagcggcat ttcgtaaagc tcagctcgcg ccatcgtaat 3655381 ccctgataaa tattcaggat agcctggatt cgggactaaa gcgatgtctc ccggattgag 3655441 caggcattgt gtcagcacat acaatccggc tttcccgcct ccgaaaagcg cgacttccgt 3655501 ttcaggattg attgtcactc cgtattccct tttatagaaa gcggcgatcg cttcctttaa 3655561 aaaaggatag cccctgaaag ggccgtatcc atgaaacgaa ggattcagag aagcctcccg 3655621 caaagcctcg acaatatgcg gcggagtggg aaggtcaggg ttcccctgtc cgagattaat 3655681 gatatgggct cccgtttttt ccatttcctt taccttttga aaaacgagag aaaactcctg 3655741 ccttggaagt gtcttgatga catcggacgg tgttatttcc atctaaaaga ctcctttttg 3655801 ctccgttttg ttatcccgtt ccaaaaacga tttgttgacg agcttcgtat gcaaaaacaa 3655861 accgcatacg atcacgacaa tcagccccat aatgaccgga gcgcttagga tgttaatgaa 3655921 cattgaacca atagaaatgc ataatccgat agacgcttcg gccactgaaa aaatgcgccc 3655981 ttgaatctgg tttgccgcat tttcctgaac cttcactttt gcaagcactt ccccgtattc 3656041 catcgcgatg aaaaagagga tcgccgcgat gacagaaaca gcgaatatcg gtgtgaataa 3656101 aaacagcgcc agcgagacaa tggataaaac ggtaaagtac gtcaggcctc tattgttgtt 3656161 aaagccccat ttgctgacaa gcgccgctcc gataaagccg ccgaagccga tgcagaacgt 3656221 gagaataaag ttgccgattt ccccgtcacc cagaaagcgg ctgacaatcg gaaaatagct 3656281 gtacacaact ccccacagca aagccattgt aatcatcgta aacatggcgt ttaatacgaa 3656341 tgaattggtt ttgatttcct tgagtccttc cttaaaagac tgaaaggcct ctttaatgtt 3656401 ttcagattga atcggcacaa attgcagctt gatgcggctg ataaaaaatg ccgaaaccaa 3656461 gtatgtcaca ccgttaaagg caacagccag ctctacagat ccgcctaaca gaaagagccc 3656521 tccggcagcc gccccgacga taatggagat ggttgtcgct tttgcaaata acgtgttgat 3656581 gcttttaata tctgattcca aggacgacat gacagcgaga cgggcgggat taaaaaacac 3656641 gccgcttcca taagtaataa acagcagggc cagaaaaatc agcggatact cgccttttgg 3656701 aagaaatgtg agccccaaaa agatgatgcc tctgatgata tccgtccaca gcatgatctt 3656761 aattctgtct aaccggtcga ccagaacacc caaaaacggc tgaaacacca tcggaatgct 3656821 tctgaccacg atgaccccgg acgtcaccca ataatcgtga taatatgtag acaaaatgag 3656881 cagggcaggg agaacacaat agtctcccat gaacgatagc gcctgcccgt aaagcaagta 3656941 tttagagttg ggtttcagct gtttcatact ggcagcacat actttgccgt cagcttcgca 3657001 tgctgctgaa tttgtctgat tgattcagcc acatcctgtg aattactgcc tttcagttca 3657061 aatgcagcaa tggaattgaa agcttcaaac aatgtcaaat caactgaagt gcctggtgct 3657121 gcggccgaaa aagaaacgat ttcagtatcc ccttttaaaa gcccgtccgg aatatcgatc 3657181 gcttcaatga ccaaatcctc agcagtttca ggaatttggc cattttgttt gaaatgctgc 3657241 gggtacaaat ggcagtcggc aacataataa ggctcttgat ccaataatcc gtccggcaga 3657301 tcggcgtctt ttccgaaaca gaggacatct aataataatt gcgccatatc aaggccaaag 3657361 acctttttaa tattggggat catattccag ccggcaaatc tggctgccga ctctattaaa 3657421 cccggttctc tgtttttcat tagcttgatc tctgtatgtg ttgcgcaatt ttgcagtcca 3657481 agcccttcat ttgccttttt ggcagcttcg acaattttct tttttgcctc ttcatccaga 3657541 atggacggcg taatgtggga tgtctctgta aacccgattt gcggcgtttt atcatgaatg 3657601 gcgatcggga aatactcacc gtcagccatg atgccttcta tactgatata gtcggagtac 3657661 ccttctgttt gataccagtc tccgtactca ccctgtaaaa attcttcagc gataaacggc 3657721 gcttcaaacg taaccgcctt tggcacgtta attgatttca gatagtcatt gactctgtta 3657781 aattcatctt ctgccgtctc agtgtccgta atcagcgtta caccgataga actcgctaag 3657841 tatgtaggct ttaagataag aggtgtgccg atctcttcaa gagcagcacg gaaatcttca 3657901 agagttgtga ctcgtttgtt tttgatcgat ttgactccgg ccttattaaa agcgtccctc 3657961 attttatttt tatctctggc attttcggct gcctgcacgc cggcacctct caagcccaga 3658021 cgttcacagg ctttcgccat cggagcaatg aataattcat tgtttgttgt gatggcatcc 3658081 gccccaaaca tttcggcaac cttgacgatt tgctcgacga cctcttcctc aggcttgtta 3658141 tgatcttcat gcgcccaata aatggaatca gggtgttcaa aatcagctaa actcttaaaa 3658201 tagtctttat cttttatgac cgcgaccgag tatttttcaa tcaatgctgc atgggaggct 3658261 gtaattgcaa aaggtcttgg aataaagctg accaggttat atttttcagc agcgctttta 3658321 taaaacatgt gcggcgggca gcctccaaga tcagcgatga ccaatactgt ttttctctcc 3658381 atatgtaaaa cactccttct ctattgtgcg gtgtatcctc cgtctgcggt gatggcgctt 3658441 ccggtcatat agcttgataa atccgaggct aaaaacagca tcacatttgc gatttcttca 3658501 ggtttcccaa gcctcagcag cggatttacc ttcgcttttt cttttttaat ctcttcaagt 3658561 gtgccttcat tattttcaag gaatgatttt tcattcagcg gtgtgtcgat gatccccggg 3658621 catacgcagt tcacccgaat ttgatgtttc gcataatcaa cggccattga tttagtcagc 3658681 tgcaaaaccc cgcctttgct ggcgttataa gcaggaatat caggccatgc cacgagtccg 3658741 ccgacagagc acgtattaat gatgttgccc ttgccggcgg ccagcatatg cttgagtgca 3658801 tgtttgctca ttaaaaacat gccggtcaaa ttgacttgca gcaccttgtt ccaatcgctg 3658861 agctccatct cgtgaatagg cgccacgatt tcgatgcctg cattattaat caagacatcg 3658921 agcccgccaa atgtatgaac cgccgattca actgcgtgct ggcaggcagc ttcgtctgtg 3658981 atgtccgttt gcacaaagtg cagcctgtca ttattttctt ttcgtaccat tgcttctcct 3659041 tgcgcttcat caatatccgc cacaaccaca ttggcctgct ggcccaaaaa agcctgaacc 3659101 gcagcataac caatgcctga tgcgcctcct gtgatgagga cggttttatc ggtgaggttc 3659161 atgatcattc atccgccttc attttttttg cttttgccct gttatagcgc ggcgggaaga 3659221 agatattaat cgattttgat tctttttctg aacggttgat ggcaccatga tcttcgcgag 3659281 gctcacagaa ataggctgtg ccgaatttca tctcgactgt gcagccttcg accgtcatgt 3659341 catagccgcc gccgatgcag atgcctattt gttcattccg atgtttatgg aaaggcattt 3659401 ctccgccatt tccagggatt ttggcaagca taatttctac ccaatcctca acaaagaacg 3659461 tgacttccat gcccggcagc aggtctcttg ttttgaaaat atccaaaaag tagtcctcag 3659521 gacttgtata tgtttcatca gctttcagcc gcttgatatc aatagcaatc acttcttggt 3659581 ctgtgtcgtt tcttgccccg tgaggcacat gcggcggcgc gatataggca gattccaagg 3659641 ctgtcatttt tcttgtcaca tctccgacag tcatcatcag ctcgccagaa acgaccatgc 3659701 cgatttggac ctccttatgc tgatggggtt caacattggt atgcggcggg acgtaagaca 3659761 ttaatacttc agtatcccct cgtacggttg aatactgcct cactccgttt tcccattcaa 3659821 ttaatttcgg tgtcgggaaa taaagctcct gcatatcttc tttagttttc atcatcaacg 3659881 tctccttttc caaataatga ccagctcatt ggaatgcttt tgaatgtttt tacaaaggtt 3659941 agcccgtact tttgccgtgc aagctcattg gttaaggcaa tgtcatacaa accttctttt 3660001 acttttcttg cggcttgact ggttgaattg actagtttga aacgaacatc tttgcgggta 3660061 aaatatttta ttaaattaat aggtgaagga tgtgaaacaa taacagatgt atcaagcata 3660121 tcgtctctga attcaaaatc aggacgaaca gccaggccgt acatcggtgt atcgcacctg 3660181 aagatctgca atagctgcaa atccggcctc atgtagaaat gcttaatgcc atcgtaagca 3660241 tgtgggacga tggtatattc cagcgggctt tggagcgtcc tttcgatgca cgattcaaaa 3660301 gtatcatgca aggacaattt actgttcagc ccttgtagaa gagtaaaatt ggaaatgaaa 3660361 tgctttgctg cgtactcact gcttgtcccc tcagggccga gcgtgttgac tgtaatgagt 3660421 ttggatagtg aatcagttct tttttttgtc tgaatgctat tatccaatat aatcatgagc 3660481 accaaccaat cttttaaaat tttaagtaaa ttttatccag tggaaattga actgtcaatg 3660541 ttttttgaaa atattgataa ttattcccat acaaacaaaa aaacccttta aaaagggttt 3660601 ttaattatag gaatttagaa actttgttta ttgagataag gactgatcgg ccttctgctc 3660661 aagtttgccg tactttttat atgcgaatac actgagcaca aatccgagga ctgtgatggc 3660721 ggcgcaaatc aatccgacag ctgcatagcc gtatgccaca tatacgggtc ccattaaagc 3660781 agaacctaat gtcacggcca gattcgaggc gagactgtaa aacaccatga cttttcctcg 3660841 atgacgctct gagcagtcac tcaaaatggt gctgagcagc gtcaccgtca aactttgcat 3660901 taatccccaa ataaataggc tggcgattaa cagaaacata gacgccggcg catatggtaa 3660961 acacgccagc agaacgctga tgacccccag cgcaatcaaa agggagcgca tttttccgat 3661021 gcggtcggct atctttcctg taatcacact catggaaaac ccgattccat aaatcatgat 3661081 aaataagccc gcagccgtgt ttcctccggt aaaaacgtcc tgaagatagg tgcctaaaaa 3661141 ggaatacata ccgtaaaaac caatcatatt acaaaaggtt attgtgatat aaacaggtac 3661201 acgagggact ttcagcgcat cccggaatgt tcctgcgggc tcttctattt cttccttgcc 3661261 gctgttttta tgttgggcat ggcggcgcat ttcaaggaga atcagcagaa caactaaaac 3661321 acccatcagg gcgaaaatcc aaaacgtcca tctccaatgc aggacgccgc cgataaatga 3661381 tccgagcggc actccgaaaa tcagcgccag cgaccagctt gaaacgatca gtcccatcac 3661441 cttgccccgg tatgtataag gaacacgatc accgacaact gcgtaagcgg tcggaacaaa 3661501 cgctcccgca gccaatcccg aaagcgcccg gcctaaaaag aagaaaaaaa tattttgagc 3661561 taaagcgcat atcaccgttc ctatgataaa aatcataagc ccggccaata agctcagttc 3661621 tctggagtat ttatcgccta atggaaccaa aagcggcgca ccgataaaaa tcataacgcc 3661681 gtaaatactg atagataacg caaggacgct gacatctgag ctgaaggctt ttgctaaatc 3661741 cggcagcagc ggtgagatca caagctcttc agatccggct gcaaataccc ccatcgttaa 3661801 agccagtgcc aacaataacg gaaaatgatg ttttgttttg atgtcattgt tttgattgct 3661861 gttcattctt tctcaaacac ctcttccata atcttcttat cataaagttg tattatagtt 3661921 tagcattgtt ttttctctat ttacaattcg aacgaaatat ttataagttt tattattttc 3661981 atttaaatcc cattatatat ttctatattt cattctaaaa atacatgagg atgtaacacg 3662041 taaaaaaagc tctccggcct cccggagagc tttttctatt gcgcctctgt ctgctttttt 3662101 tcaatcgttt catgatttat acgctttttg atgcttagat gatagtatgc ataacagaaa 3662161 ataatgatcg gcacaccgca gtataagcca attctttgat ccggaatgaa aataaggctg 3662221 atcaacacgc agccatataa acaaaatccg agaatcggga ctagcggata aagcggcgtt 3662281 ctgaactcca gatcattcac atttccgcct tctgccagga aacgcctgcg aaagaaaaat 3662341 tgcgacgcac aaatggacat ccacgcgaca actgtcacca tgcccgagat tgagatacac 3662401 cataaataca ctgtttctgc agccatgaca cttgtcagca gcgaacagcc tgaaatgcct 3662461 agcgtaatca gcagggcatt catcggcacg cctttttttg tcagtctggt gagaaaggag 3662521 ggacccattt gatttgatga aagtgaccac atcatacgcg acgccgcata caatcccgaa 3662581 ttagcaacag ataaaatggc cgttaagatg acaaagttca tgatatctgc cgaaaatggg 3662641 atgccgattt gatcgagtac tgctacaaac gggctttcaa tcacccccgc cgttttgtac 3662701 ggaaggatgg caaccaagac gaacatagcg agcacaaaga aaaacagcgt gcgccaaata 3662761 acatttcgaa tggactttgg cagtgttttt tccgggcttt cactttcccc tgccgcaatg 3662821 ccgacaagct ccgttccctg gaacgagaag tttaccatga ccagcgtaaa cataacggcc 3662881 agcaccccat tagggaaaag ccctctatca gtcataaagt tagacaaaaa gggtgtctcc 3662941 tgtccgcctt taaagtcaat caagccaaac acagcggctc cgccaatcac aataaataat 3663001 atgatcgccg ccactttgat gcttgaaaac caaaattcca tttccgcaaa gcttctgaca 3663061 gagagcgcat taatcaaaaa gatgacgatg ccgaacacga ggcaccatat ccagatcgga 3663121 acggagggca gccacctttg catcaaaatg cctgctgacg tcagctctaa ccctactgta 3663181 ttggcccagc tgaaccaata cagccagcca atcataaagc ctgtcgactg tcccagaaat 3663241 ttagtggcgt aggcctgaaa cgatccggcc accggcatgg caacagccaa ttctcctaaa 3663301 caaagcatga cgagatacat taaaaatccg ccgatgatat acgcggcaat ggcgccgagc 3663361 ggtcccgcct ggctaatggt aaagccagag cctagaaaca gcccagtgcc aatcacccct 3663421 cccaaagcaa tcataaacaa atgcctgctt ttcatgctgc gctgcaattc atttttatga 3663481 ttctgcatca tccttccccc tttggttctt ttgccgtgat ggtcatccgg tagctttgca 3663541 aaagatgaac ggtggtttgc tgtatgagga gaggcaatac atgaaatgtg tacggtttat 3663601 agactcgttc tgtccattta tggccgtctt ttccgtacac gcccatatta atggatggaa 3663661 tattcagctt gcgtatgtct ttgaacggaa tggtcccaat catattccac ccagggaagt 3663721 tcctgataaa agaatcaatt tcgccatcgg tttcgtgcag tgataaaaaa ctgccgtctg 3663781 ccaagtaggg gaaaaacttt ttgaagacaa atgtttcgcc tgtcgattca gcggttttgt 3663841 cagccgcttc tttaatcaca tgctgcaaaa gctgatctct tgcgctatct tctttcaaat 3663901 agttatgcgg caggtaagga ggtgcgtaaa atagaatgac ttttgcgcct tgatcggggt 3663961 caagcttttg aagctcttcg attgcctgaa agcatctcat gcgaagttca aggtgctcgt 3664021 tggctttgaa tgtctgctcg atacactgct cgggatctat tccccggttt ctcagctttt 3664081 ctaagtattg ctccaggcta tacacttgaa tgccccatga taaatgtttc tttggcaggt 3664141 tggctctttt tacatattct tcgtaataat ctgataattt ttgttctgtc tcccggcatg 3664201 cttcctcagt gacttcaata agcaaatcca tcatttcttt tgctgttctt tcataaataa 3664261 aacaattgaa atacaagctg gtgctgacag ccgtttgcac attataggat tccttgttat 3664321 cacgctgata caaacaggat gggggcagaa ccaactcccc ttcaaccttt tctgccagat 3664381 ggatgttatt gtggagacgg cttgtgattt cagatgaaat gaaatttggg tcaatccctg 3664441 ccagtgtatc gccaacatgg acttcacgcc cgtaaatgta aaagcaaggc aacagttttc 3664501 ccgcggctcc ggtatagata tatcttgtct gatcaccatc gtaaagcggg gtaataaaat 3664561 ccgtattaat agcagccaaa tagtgaagct gtttttcttt ttttagccgg ttcagctctg 3664621 aaatgctggc gagaatgccc gaatgctggc tctcctcatc gggattggcc ataaacaata 3664681 catttcccgg caacgtctca aggttctccg aaaaatgcag gagattggct aaatgcacgg 3664741 cgatgccgct ttgcatatcg acagatcctc ttccgaacat ccactcgcct gatttggcat 3664801 cccgctgaac atcctgatcg aactcatagc ggctgaaata ctcggccaat ttctcacaat 3664861 caaaagcgat atcctttaaa gggccgaaat cttcaattcc aactgtatcc agatgggcat 3664921 ggtaaatgac tgtatttcgg ctttctccat gtcctttaat aaacgcaaaa atatttttgc 3664981 gtttgtatgg gtcattggga atggcctgtt cccacacatg actggggttt tcctgaaaat 3665041 aaggatagct cgtgatcact tctttgatga aatctgcttt tgtcccttct ccaacggtgc 3665101 cgttcacgct gctgaggctg accagagatg ctgtcagcgc ctccactctt tcagccggat 3665161 tcatgtgact gatttttgta tactgcataa attgtcctcc tgatcaaaaa gttgaaatcg 3665221 tgcgatccgc taaagaatcg cacgatttta tttctctcaa atcaaaaagc ttcggacgtt 3665281 gttttggctt gcatatgaag aattaagtaa tcgggaccgc ctgcttttga gtctgttcct 3665341 gacatattaa aaccgccgaa cggctgatag ccgacaattg ctccggtaca tcctctgtta 3665401 aaatataggt ttccgacatg gaaatcctcg cgcgcccgtt caatgtgcgc acggtttttc 3665461 gtcagaagcg cacctgttaa tccgtattcc gtgttattgg caatctccag catatgatcg 3665521 aaatcacgcg ctttgcaaat cgcaacaacc gggccgaaaa tttcttcctg catcaagcgg 3665581 gcgttttcat caacatctgc aaagatcgtc ggctgaataa agtagccttt tgaatcatcg 3665641 ccttctccgc cggccaatag cttgccttca gatttgccga tttcaatgta tttcatcact 3665701 ttgttgtagg atgcttcatg aatcacggga cccatatacg tatcaggatc ttctggattg 3665761 ccgacagtca gcgttttggt cagcgccaca gctttttcca ccacttcatc atacacatcc 3665821 tgatgaatga ccgcgcggga gcccgcagaa cacttctgtc ctgaatatcc aaatgctgaa 3665881 tacacgatag aggatgcagc aaggtcaaga tcagcgtcct tgtcgacaag cactgtgtct 3665941 tttccgccca tttctgcaat tacccgtttg agccattttt ggcccggctg cactttggca 3666001 gctcgctcat aaatccggca gccgactgca cgggaacctg taaatgagac aaaccgtgtc 3666061 ttcggatgct caactaagaa atcaccgatc tccgcaccat ctcccggaat gtaattcaga 3666121 acgccgtttg gcagacccgc ttcctccatg acctcgacaa attttgctgc cactaccggg 3666181 gctgcgtcag ccggttttaa gagaatcgta tttcctgtca caatcgctgc caccgctgtt 3666241 cccgccataa tcgcgagcgg gaagttaaat ggagaaatga cgatgccgac gccaagcgct 3666301 tcgtaatgat attgattgac ctcgccagca cggctcttca ccggagcccc ttccttgagc 3666361 tttaacattt ggcgcgcgta gaactctaaa aagtctatcg cttcagccgt gtccgcatct 3666421 gcttccttcc acggttttcc tgcttccttc acaagatagc ttgaaaattc atgctttctt 3666481 ctgcgcaaaa tagccgctgc cttaaagaga atatttgcgc ggtgctccgg tctttgtttt 3666541 ttccaggaat caaatgcctg caatgcggct tgcatcgctt tttcagcaag ctcttgatcc 3666601 gctgtagacg cgtacccaat gatctcttct ttatttgccg ggttaataga aatgattttg 3666661 cggtccgttt caattttttc tccatttatg acaagcggat aatgcttgcc gagctgagtg 3666721 tttacaaagg ccaatgactc cccaaatgca gttttattct ttgcttccgt aaaatcggta 3666781 aatggttcgt gcgcgtatgt gactgtcata tgtagtcccc ctcgtgttat gaaatatatc 3666841 ttcgcatatg aataaaaatg caagaatcat gccattttct tgtcttttgc tgaaaaaact 3666901 tgttgaatcg aacagaaatt tgtctaacag gtgatcacct ttctcttttt ccgatcttga 3666961 acgcaaattt attttgcgtt ttttgctctt tacgcaaaaa acaaatgcaa aattattttg 3667021 cggaggcttc tcaaattaga cccatccgcg gaaacgcgat gcttctgccg attttctgat 3667081 gcccgtcatg taagccgcca aacgcatatc cactttatgt gttgccgctg tttgataaat 3667141 tgtttcgaac gagctgacca tgacgcttct cagtttttct gcaacctctt cttccgacca 3667201 ataatatcct tggttgtttt gcacccattc aaaataagaa accgtgacgc cgccggcact 3667261 cgctaggata tccggcacaa gcagcacgcc tctttcattc aggatcttag tggcatcaat 3667321 ggttgtcggg ccgttcgccg cttcaacgac gattgacgcc tgaatgttat gtgcgttttt 3667381 ggctgtgatt tgattggaga tcgcggcagg cactaaaata tcgcaatcct tttcaagcag 3667441 ctcctcattt gtgatgacgt cagtaaataa attggtgacc ataccaaagc tgtcccgttt 3667501 atcgagcaaa taagggatat caaggccgtc tgggttgtag agcccgccat tggcatcaga 3667561 aatcccgatc accttcgcgc ccgcatcgtg catgaatttg gccaggaagc tacccgcgtt 3667621 tccaaagccc tgtatgatga tgcgcgcgtt ttgcagcttg atcccttttt tcttcaccgc 3667681 ctcttcaata caaatcgtga cgccctgtgc cgtcgctgtt tcccgtcctt gcgatcctcc 3667741 caaaacaagc ggtttacctg taataaagcc cggagaatcg aattcccgca gccggctgta 3667801 ctcatccatc atccacgcca taatctgcga attggtgtac acatcgggag ctggaatatc 3667861 ctttgtcgga ccgacgatct ggctgatggc acggacatac cccctgctca gcctttccag 3667921 ttctccaaat gacattgtcc gcggatcaca aataataccg cccttcccgc cgccgtaagg 3667981 aagattggca atcccgcatt tgagcgtcat ccaaatggat aatgccttta cttcctcttc 3668041 attaacttct ggatggaagc gaacgccccc ctttgtcgga ccgacagcat cattgtgctg 3668101 tgaccggtag cctgtgaaca ctttgacgct cccattgtcc attttgaccg gaatgcggac 3668161 agtgagcatt ctctgcggct ctttcatgag ttcatacata tctcccggat aacccagctt 3668221 ccgaagggct tccttaatga ttgtttgggt agacagaaat aagttaagag cttctttttc 3668281 ttcatctttc gagacttgct ttgctgacat ctttttcacc tcattgtttt tttggccggc 3668341 tgtaatgtaa gcgctttaaa aaatcagccc gccaattcct ttcttcattg gattcaccct 3668401 tatcatcatg caagatccgt accagctttt gaatccacaa aaaaagagac tgaaaacatc 3668461 tcagtctctg actacaaatc tatcgattaa cggggatcaa tcaccagctg cgtttcagca 3668521 taaaaactgc cgattcccaa accgtttact acatcgcctt taatcgtgta agtgcctgcg 3668581 cgaggaagag ttttacgcac catgacaagg tcaaattcgg atgcgcctaa caaatcaagc 3668641 gtaagcggga gtctgactgt ttttccatcg tttaaaatct gtgtttcttt cagtgttctt 3668701 ccattcactg aatctcttgt cgtagcatga aacccgtcag gaaattgaaa ttctaccgct 3668761 ccaagagaaa gcaccgcatt tggtttatat gtcacttcaa tatcagaaat ggtccactct 3668821 ttcgtgctgt taactgtttt tgcctcgatt gatgcagact gtgcatgagc ttggcccgaa 3668881 ggaagtaaga ttgatagtaa aacagctgaa ctgatgaata atgaagatac gaatgaagtt 3668941 ctttttagca tgacatttcc ccctaattga ttgttgaaat ttggccagag cgtcctctgc 3669001 agaaaaagcg ctttttcata attcgcgaat taccagttct ttttcttaaa aattaatcta 3669061 tcatcatttt ccatggaagt aaatgttttt taaggaatat taacacttgg aattcaatga 3669121 gaattccttc ctgtttatac aaggttcaaa tggacgattt ccctctcttt ttctagtaac 3669181 atctgcctga cattttatat cttttatcct attttaaaaa agggcaaaaa aagtcgaaga 3669241 tgcctctgct cttcgattga tcacgttcct atttttatct gaattcagtg ttccagttaa 3669301 aaccgatcgt ctcatcatcc cacggaattc ttttttcatc aggctgatcc gggttatacg 3669361 acatggtggt aaaatagata attgtcagcg gcgtctctcc cagcactcta tatccgtgag 3669421 ccaccccttt tgggattaat aacagcatcg ggttgtcttc gcccatataa tagacgtccg 3669481 tttctccttt tgtctttgaa tcctctcgaa gatcgtatag gacaacctga gcgtggccgg 3669541 ttgggaagaa ccagagatca tcctgcttct catgataatg aaatgcctta atcacacccg 3669601 gatagctttt cgaccaagag gcctgcccaa aatgctcaag gagattctca tcgtcccgga 3669661 ccagctcagc aaaaaagcct ctgtcatcgc tatgcttcat caattttttc accttgactc 3669721 catcaatcac acgcactgct cctttcctgc aaatactctc gtaacgcttc ccgccagtgg 3669781 cgggggcgga tgccggcttc ttcaatagcc cgatggctca gcacagagta tgccggacgg 3669841 ggcgttttgt tcccgtattc ctctgtcgtt acagacaaaa tggctgtttc cagcccgctt 3669901 tcttccataa ttgccgtcgc aaactcatac cagctgcata tgcctgaatt gctgacatga 3669961 tagatgcccg gcggatggct gaacagcttg atgaccgctt ctgctaaatc cttcgtataa 3670021 gtcggcgaac caatttgatc gctgacaacc cgaagctctt gtttcgtttc agcaagtttc 3670081 agcatggttt caacgaaatt actgccgcca tgtccgtaca cccacgatgt cctgatgatc 3670141 gtgctgtctt ttgtcgttaa tcgtatcagt tcttctccga gccttttgct tttgccataa 3670201 atggttttcg gatcgagggg atcgtcttcc ctatatggct gggttccttt cccattgaat 3670261 acatagtccg tgctgatatg aacatattga gctccgatgc gggttgactc aagcgctgta 3670321 taataagcgc cgattccgtt aatcaagtac gctttatcaa gctctttctc gcattgatca 3670381 accgacgtaa acgcggcgct attgaccacg atatccggct gataatggcc aaacgaatgc 3670441 cgtactgagc gctggtcagc aatgttcatc atcttctttg ttaacgcaat gacctcatat 3670501 ccggcttgct tcagctggcg gcatagttcc aagccaagct gtcctcccgc cccagtcacc 3670561 aatacctttg tcaatcagat caccttctca tcggtcattg tctgtatacc actgaatcgt 3670621 acgcgcaatg ccttcttcaa acgtcacttc ctgccgccag cccagttcgt ttttcagctt 3670681 tgatgcattg atcgcatagc gccggtcatg cccttttcgg tcttccacgt gggcgaacaa 3670741 ttcctcacag cccagatgct tcaaaatgac actcgccagc tctttattcg tgcgttcatt 3670801 tccgccgccg atgttataca cctcgccgtc ggtccctttt tctaaaatca gcttgatcgc 3670861 gcggcaatga tcctccgcaa acagccagtc tcggatctgg agtccatcgc catacagcgg 3670921 aacaggcagg ccctgcttcg catgacggat aatcgtcgga atcatttttt cgctgtgctg 3670981 ataaggtccg taattgttgc tgcatcgtgt aatgatggcc ggaagcttgt gggttttcac 3671041 ataagacaac acgagcaaat cagagcttgc tttgctggct gagtatgggt tattaggaga 3671101 aagcggcgtc gtttctgtaa acgcgggatc atccgctttt aaatccccgt atacctcatc 3671161 tgttgaaata tgaatcagct tcttggcttt tcctttcaag accgcttccg ccaatcggta 3671221 tgtccccatg acatttgtgg tgataaacgg ctccgcttgg gaaatgcttc tgtccacatg 3671281 cgattctgct gcgaagtgaa tgacgccatc gtaggtctcg tcaaaagcgc ggtcgatatc 3671341 ctcctgaacg ctgatgtccc cttttacaaa gcgaaaacgg ctgttttgct ttaatttttc 3671401 catttcctcc gggtggctgg cgtacgtcag tttatctaaa acggtaatgc gcgcatccgt 3671461 ttccctcagc atgagctttg taaacgtgag cccgatgaag ccggccccgc ctgtaattaa 3671521 atatgatttt gccatcactt ttcgtcctgt cctttccgta aagcctggtg tacaagctgg 3671581 gaagcgagat aaagcgattc gtgagttccg gcatctaccc accagcctga taacacatca 3671641 tacgtaagct ggctgttttc gatgtataga ttattcacat cggtgatttc cagctcgccg 3671701 cgctttgatg gtgatatttg ttcaatatat gaaaacacct ctgcatcata catataaatg 3671761 ccggtaacac aaaggttggt cggtggctgt tcgggctttt cgatgatgga acgaatccgc 3671821 ttgtttttct catcaatctc agcaatcccg aaacgttccg ggtcatcaac ttctttcaga 3671881 agcacttttg ctcctttccc ctgctgttca aagcgttctg tataaggctt taatgaatct 3671941 tcaaatatat tatcacctaa taataaaatg aaagactctt ttttcgtaaa gcgctttgca 3672001 taagacagcc catccgaaat gcccgatgct gccggctgta cttgataagt gatagtaacg 3672061 ccaagctctt ccccgttccc aagcagtttg taaaattgcg gcatatgctc cttttggctg 3672121 atgagtaaaa tgtcttttat tccggcttcc tgcagcttca taatcgacca gtatatcatc 3672181 ggatacgggc ctacaggaag caaatgcttg ttgacggctt tcgttaaggg cataaggcgt 3672241 gagccgtttc ctccggctaa aataacacct ttcacattaa cacttcctta catgcatttt 3672301 tatatctctt gttcatataa atcttgaaga atagctgtta cccgtataat gcctttgcca 3672361 tccacgagcg gccttcctcc cttgtgcaaa gaaaggcgaa gaggatagct gctcataatg 3672421 cgtgacatct gatagatgag tgtttcatcc ggtacaagct cacccaatcc aagatcaaga 3672481 gcggcgcctt ggtcagcaaa tgttttggct gtagccgttt gatgctcaac ctgagaaaga 3672541 acaaggcacg gcacgccgat gcaaatggct tcatatagag agatgccgcc agcgacaatg 3672601 gctgcgtccg cttgtttcat caaacctgcc atatcatttg tctgttcgat catcttgtac 3672661 tgcggcttct tttcgatccg ccttcggact gcctcttgat gcggtgaagc gctccccatc 3672721 acaaacatca tgtttttgtc ttttatgtcg gggacttgat cagcggcagc cagcacttta 3672781 aaaataagct gcttcggatc acttcctcct aatgcaacaa ggatattgcg gcagtctttc 3672841 ttaagtgtgt aatcctctct tgcggcctga aaggcggggt gaagaataag atagtccgga 3672901 ccttcataga tgcgtgtgtt tccctgaacg tacaccctgc ttctgatgtc accgtaaatt 3672961 ccgttaatga ctgcgtcact atattgaatc gatttaccgt ttttctcttc aaaaagaaca 3673021 attttcgcat ctgtctccgt ctttattttc tttaacagct ctgcaggcgc gcctagaata 3673081 tcaaacaaaa gcaaatcaag cttcttgctt tttatttccc ggagaataaa ttcgtgctgc 3673141 tgcagctccg gctttacgat gacctgccaa tgctcttcat gaagaaacgc ttcagaatcc 3673201 tgattcgtat aaaacgtaat caagcatcgc tgtttgagcc cctccgcaag cctcttcatc 3673261 cggacaacat ggcccattcc cttttcatag ccgccgtctg cgaagatccc aacatgcatg 3673321 gctagtcagc ctctcgttcg gttgccgcat cggggttccg gttcagaagg gtgataagct 3673381 ctgaggcgga tacatcgggg cgctcgcctg ctttttgata gagggccttt atcgattcat 3673441 agtcttcctt tgtatcaatg gtcagccgat attgaggggc gcgaaatcgt tccggcgcct 3673501 ctaaaaactg aacacgataa agagctggat gattccttat atataacgtg acatgctcct 3673561 gatattgatc ctccaaagcc tgaatacggc tgatgtcaat taacaggttg gcgttgacca 3673621 cttcgccgca aatccctaat ggggcattca ggatatacgt ataatccgag ccttgatcaa 3673681 aatgcgcctg aatcattaca tcgagcagct caggatcgac aaacggatta tcacctgtta 3673741 accggatgat gactgacggt ttaacagctt ctatgacctt cacaaaccta tcgaggacac 3673801 gttcttcgct cccgcggaaa acacgaaagc cttgtttgat acagtgcgcc tctaatatgt 3673861 cgtcagtttc tttgtcagac gtggcgatga caagattatc ccgatccttt tggtaaaacg 3673921 cgctttgccg gacacggtga acgagaatat caagtaaacg attcgatccg agcggccgaa 3673981 gcacttttcc cggaagcctt gttgaaccca ttcttgcttg aatgataaag agaatatcat 3674041 tcatgaaacg ggctgtcctt cagtaaaatg tcatcccaga caatgcctgt gtcggctgga 3674101 atgtctctta cagcccgaac accgctggtc agcagttcaa aaaatctcgg gtgcagcccc 3674161 tgcggctttt gtccgggccg aagcactgcg atattgtctt cactaaaggc ttcacctttt 3674221 tgaatcggag ctgttgtaaa aatgcctctg tatgcaaagt ttctgatttc tccttcgatg 3674281 gcggtcgttg ttttgtatga actgccaagc agtttttcag agaccggctt tgtgatcccc 3674341 tgtttcagct cagcttccgt tttcctgatg ccatcgacca tttctttcaa ttcatccgga 3674401 tttaatgcaa acgagtggtc agcacccggc agatttttat cgatcgtaaa atgcttttct 3674461 atcagttttg ctccgagccg aaccgcggca cacggcgctt ctgtcggatg ctcgctatga 3674521 tcggagaagc cgattaccgc ctcaggaaaa gcggcggcaa gcatcggaat gacgctgagg 3674581 ttgctgtact ccggcggtgc tgggtatttc gccacacaat gcattatggc aatttgattg 3674641 tttccctctg ccctgatggt gcgccaagct tcgtgaacat cagagatttc agctccggct 3674701 gtcgagaaaa tcatcggcct gttcagccgg gcgacatatt taagcagcgg gagatggtta 3674761 atttcatagg atgcgatttt aaaagcgctc ggcgaggtag actgaagcag atcagctgac 3674821 ccctcgtcac ataccgtact taaaaagatc acctgctttt cgcggcagta atccaatagc 3674881 ggtaaaatcc actcagcagg catttccata gattgaacca aagaaaaaat agagacgtcc 3674941 ttgcccgctg ccgtcttgta caaaccagga tctttctggt acatcctatc agcttggaac 3675001 atttgaaatt tcacggcatc cgctcccgct tccgccgcgg cgtctatcag cgcaaaagcc 3675061 tgatcaagct tcccgtcatg attaatcccc gcctcagcaa taataaaaac aggagcgtct 3675121 ttgcctacag ttttattcgc gatctgaaac gctgccatta tttcgcctcc ttgcccggcc 3675181 aaatatgata atagtaatac gattgttcag cggtgaagcc cattcgttca taaaggcgga 3675241 tcgcccttac attgtgaagc tgcgtccccg ctgttaccgt tctatgcttc tgggtctccg 3675301 gttgttctat gagattcgcc aataaatgaa acgcaatacg tttcccttca aatcccggct 3675361 ttacagccat caaatcgaga atgcactcat catctcttga taagccctga agatagccga 3675421 tgacctcgcc attgtgttta gcgacaatat tgaccgccgc ccttccattc agattgtttc 3675481 gtgtccactc ctgaaatatt tcgtttgctg catcgcggct gagatgagga tcctgaaaat 3675541 atctgctttt tgtaaacgag tctcgggcca gctcacatat cgcttctgtg tctccgggct 3675601 caggcgggcc cagttcaaaa aatggcggtg ttttgtcata aaaagacgga ggcatcgcca 3675661 gcttcagcaa actcccgaca aagtaagagg atggctgctg ttgtatcaca tgcgcggctc 3675721 cgatatcttc agccggaaca cggacaaaga taaaatccgt ttcatccatt tggcgtacag 3675781 tataaaaagc ttcaaacagc ctctttagct gcccggtact atttgccgca agaagtttga 3675841 cgttcatgac tttcttctga agcaccttgc tttcccacaa agaatcttcg taaagcaata 3675901 cgccttggag cctgctgttt tcaaaaaggc cgagggaaaa ttgatacgga acatccaatg 3675961 taagctttct gctttggaga aattcctcaa ttgcctcttt ggagacattt tcttttaccg 3676021 tatacactta atcagcccct tttacgatat cccgcacagc ttcaatgaca tcatctacat 3676081 catcgtcaga cattgatgga tagagcggga gagaaagggt tcgtttatag taattcatgg 3676141 cattcggaaa gtccgcttcc ttatatccaa attgcttttg ataatacgga tgaatgtgta 3676201 ctggaataaa atgaacgcta gtgccgatat tgtattcatc ctttaaagcc gtaatcattt 3676261 cgctgcgcgt aaccccggcc tttttttcat caacttgcag aacatataga tgccaggcgt 3676321 gcctgccgtc atcatggaca aacggcgtga tcagcccagg aatctgctga aaagcggttt 3676381 gatagcggcc ggcaatctct tctctccgtt tctgcatatc atccagccgt ttcagctgat 3676441 gaagtccgag ggccgcctgc aaatcaaaca tattcatctt atagccgggc gattcgactt 3676501 catagtacca gctgccattt gaagaataac ggttccatgc ggctttactc atgccgtgaa 3676561 ggcttagcac ccgtatctta tcggcaagct cctcatcatc agtcgtcagc atgccgcctt 3676621 cccctgtcgc gaggtttttg gtggcgtaaa agctgaatgc cgttgcatcc ccgatagaac 3676681 cgatcattct ttgcttataa gtcgtatata ccgcatgtgc cgcatcctcc agcacgaata 3676741 aaccatgatt ttgggcaaca gccaatattg catccatatc gcaggactgc ccgccaaagt 3676801 ggacgggcac aactgctttc gttcgcggtg tgacggccgc ctcaagcttt accgggtcaa 3676861 tattgagcgt gttttcgtca atatccgcaa acacaggcgt cgctcccgta tgaataatcg 3676921 tattggcggt cgagctgaac gtaagcggag aggtaatgac ctcgtccccg ggcccaatcc 3676981 cttttgcttt caaagccaaa aataaagctg cggtacatga attcaccgcc acggcgtgct 3677041 tcgccccgac aaacgcggca aactcttttt caaactgctg aaccttcggg cctttagaga 3677101 gccatcccga ttcaagcgtt tctgtaacct cctgaatttc ttccttaccg attaacggca 3677161 atgagtaagg gagaaaatga tttctctttt gcaccatttc tttgcgctcc tatcatttta 3677221 ttcagtatct tcccgcctgt aatcaacccc tgttttggct ttcagttccg caaataaagc 3677281 atttgttgat tctgccaccg gataattagc cgctatgaat gccaggcgcg cctcttctgc 3677341 tttttgatgc acgtcgggac ttcgaagaac ctcaaccaag gtgtgcgcca gttcatccgg 3677401 ctggtcaaac ataaaatcgc caagagactc ataatacgga tacgagcgat ttccggacga 3677461 ttttcctatc agcacaggct tttgaaacag catggcttca agaccgactg tcgaggtttg 3677521 cgtcactgcg gcatcaacat acggcagcaa atcataaagc tccagctcct ttttgatgac 3677581 tctgcatgct tgatgttttt tcgccgcctc gtgatacaga tcaagcttgt tttttccgat 3677641 ttcccacggg tggggtttga taatgatttg cagctgcttc tgatcagaaa gcccctgcag 3677701 cacaccggaa taaaagtctt ctgaaaaggg ctgagtggca atgagcacaa tttttttagt 3677761 cggctgaaaa gcaagttttc gatagaatat ggacatatcc ataggcgttc tgttaaaaat 3677821 ctgatcgaag cggggatgtc ccgttacgag aatctgctcg ggtttacagc cttttcgtat 3677881 gaaccactct gcttcatacg caccaaaaac agcttgatag gttgtaaaaa caggaatgaa 3677941 ggcttcatct cccatcaatg cgccatgctg aagacaaatg ctgacggccc cttttctttg 3678001 acacatgaga gcgagcaccc tgctgtaaat gtcttctgcc gttccgacaa taacagctga 3678061 aatcttttcc tgttcaaaca gcgcatcaac tgtatcaatg gcctctataa ataaaggaat 3678121 atctttgaaa agccggtcgc gaaacgcttg atcaccaaat gccgggtgat catcataagg 3678181 ggcgagaagc gaacaggctg tttcgagata ctgcttcgaa tcgccttttt ggcatgaatc 3678241 cgcaatctcc cgcttgctaa ttacaggcag atcacaataa tgcggcaaac tccatctggc 3678301 caaaacagcc gttttttcag gatcaaattg atagtaattt tcgtttgaaa aacgcaggta 3678361 atcaaagtgc aaaatgactt tccctttaac aggttcgtca tttgttttaa cgatgttttg 3678421 gattctttct tcaaaaaacg gctgaatctg tccctcatcg atatgctgat ccaccgatcc 3678481 gaataattcc ggttcttctt ccatcatcac cctcagttca gggctgatgt attgataaaa 3678541 attactgata agcccaagcg gaatcccttt gtagcgaagt ttgtcaaaaa gctccacgta 3678601 cttccggtac agcacccaat aattgcttaa ataggccgac aagctctcac cccattccaa 3678661 gcttttttaa tgattcacgc agctctcggc aatttcgctg cggaggaagg ttcctgacaa 3678721 attcattttt ttctaattca aacagctgaa agtgaatcga ttggtcggta atataattca 3678781 ggtccagctc ctcatccagt gggtaaaacg gataaaaatg attgactctc caaaagaacc 3678841 gggcatctcc tatacggtaa aacgccgggc tttcatccca ataggagcca aacttctcct 3678901 ttaccttctc aagcaccgaa tacctgtgca tcaccgagca atgatcaatt gcgcacggcg 3678961 cgttccatgt cacttgagcg gcaggcctga cagtttcttt tacaatgtca cgattctcgt 3679021 ttaaatgata ggttttggag gctgagtaaa tcacagcctt ttcaggatgg gtatcgagct 3679081 cccgcaccat tttcaggagg cggtccggca tatagatgtt gtcatccgtc gcataggtga 3679141 tatattcacc ctccgccatc tcaatcgcct gattgatcag tgccgcgtat ctcgtttttt 3679201 ctgttctttc cttcactcca gatatatcgc tttgataaaa acgcactcgg ttatcattca 3679261 aaaaaggacg gattacattc agcgtctctt cattggagtt gtcatccata ataaacaatt 3679321 caaaatctga aaacgtttgt gagagtatgc tagaaatgga ctttgccaca taatcgcttt 3679381 tgttatagct cgtcataatg actgatactt taggcaaatc ctacacctcc ttcttggaac 3679441 ttcacacctg aaactatcgt tatcttatgt tgcttatgct caagttgcgc tagggataca 3679501 aaccaatatg cgaaaagttt gtgtatgttt ctgaaaaaca gcggctgccc agagcgaaat 3679561 ctgatcggtc cgctgttctt tttcagcata atccaagcat cagcctcata aggtgaaaga 3679621 gataaaaatc gcaccagcga ctaagatcgt tttccatcgg aggtgagtca tcgcggagcg 3679681 ttcacctata catccagaac atgttttgaa tggttttcat aaaaaggagg aacgatatga 3679741 aaccgaaaaa aaatcaatat cagcaaatgc aggcatttga taatatgcag gggtatcagc 3679801 ctcagtttgg cgccaacccg tacccgcagc aaggccaagg ctcacaaatg cagacaatgg 3679861 ggatgcagcc aatgatgcca atgcagcagg gacagcaagg acaacaagga cagcagggat 3679921 ttggattccc gggccagcag cagggcggcg gttttcaaat tccatcgggg cctacaccgt 3679981 caggaccggg ccaaagcgtt cccggcatgc tgcctgttga ggaatcttac atcgagaata 3680041 ttttgcgcct gaatcgggga aaaacggcca ccatttatat gacatttgaa aacagcaagg 3680101 aatggggctc gaagattttt cgcggcgtca tcgaagctgc gggccgggat cacattatta 3680161 tcagcgaccc gaaatcagga acacgctacc tgctcctgac aatctacctc gattacatta 3680221 catttgatga agaaattgct tatacgtatc catattccat ggcgtcctat tcgccaagat 3680281 aagaaaaaag ccaatcactc atatgatgag gattggcttt tttgtttata gatatttgac 3680341 ggctgcgaca acgatcataa tccaagaaat aataaacgcc acaccgccga gcggggtgat 3680401 cgctccaaga atggagattt gcgtcacact tagaatatat aagcttccgg aaaacagcac 3680461 aattcccgca aacatcagcc agccggctgt cgtgacactg cctatgccgg ataatttatc 3680521 agccagaaac gcgacaacga ataacccaag ggcgtgatac atatgatact gcacgcctgt 3680581 gtgccaaacc tgaagatact tatcaggtat tttcccttct aatccgtgag cgccgaatgc 3680641 tccgagtccc acggcaagca gggcgttaat ggcccctaat atgataaaaa ctttcatcta 3680701 tctctcccgc cttttcgtta aactcatatc atttatctta tcgcacctgc accaaaattc 3680761 aatgtttgtt ctccgttgac acgagattgt cggattttct cctgcgccaa agctggaact 3680821 ggtcagctgc tattgcagca agcgtcccta atacgagccc gttgcttaat agagaaataa 3680881 ataccggatg caatcccttt aacgcagttt caggaacaaa catgataccg acccctgtca 3680941 gcagtgagat accgatgata gacctcaccc tttttgattc ttctttctca tatgaatcaa 3681001 attcggcaaa ggccagaccg cccattgcgg agaacacaac aaaattcacc gcaaatccaa 3681061 cgggtgacgg caggctcgca aacgtattca taaaaaacgg gatcacgctg atcacgataa 3681121 ccagaatact gccgagcata aacggttttt tagaaggcat cttggtcgtt tcaataaaac 3681181 ctgcggctcc cgaaatcgga acaggcgcaa tagctcccgt caaaccgcta agcagatggc 3681241 tgaatgaagc tgcaaaaccg gcatggcgtt catgatgctt tccatcaggc tgtttgctga 3681301 attttttcat ggcgatgtcc acgaccttca tgctcgccag catattcacg atcagcaaga 3681361 tggtaataaa aatagaagtg atgatcaggc cgctgttaaa taacggggtc ccaaaaggaa 3681421 acagggaagg cagctgaaac agccggtccg gcatttcaat cggctttgcg gctccggcag 3681481 ccgcaaacag cacccacccg ccgaacaagg ctaataaaat agaatattgc ttaaaaaaca 3681541 tgatgttcga atttgtcatt ataaaagcgg cagcgatcac aacaagcgcc aggccaaata 3681601 caagaccgtc caccccgtcc tgtcgataac cgattccgag aattcctttt ataatgggct 3681661 gactcagctg catgacaaga agcaataaat agacgcccgt tacaaccgga gtaaacaatt 3681721 ttgcaagtct gtcaatgacc ttgaaaacac ttaacaaaaa gaaacataca gcgcttacaa 3681781 gaagagctcc ctgcaaaccc cgcagtgtgt ctccatatgt cgcaaacaca gttcccgtca 3681841 gccctgcgta aatcgtatac actccccacc acaagccggc tgggctttca ttgatcggca 3681901 gtctgtggcc tttcaaacac tgaatgacgg cggcaattcc cagtacaaaa aaagtgcttt 3681961 gaatcaatct tgcagaatct gagtgatcca gatgaaacga ctgggcaacc gccaccggaa 3682021 caacaatcgc cgcagcaata ataaacgctg tccattgcag cgcgccaaga accaatttca 3682081 cgtaagctca acctctctct ttaaaaatca aataaagact ctccgtttcc atcctcttcc 3682141 tgcttctctt tttcttgctt tcgatatttg tttaatcccg cgctccccat cattttttcc 3682201 atcatcagct ggtctgtcga tggcggcgcg gcgggacttg gcgtaacgct cggctgtatg 3682261 cggggcgcgc tcgcgttctc cggctgatca agcacgacat cacacagaga acggacaacc 3682321 gctacataac gcttcagctc ctcatcccgt tcagccgttt ttgctttttt tagctcttct 3682381 tccatctttt gaatcaaagc agatatatga atgttcatga agcaccctcc aaaaaaataa 3682441 atgttgtctt cctgcatttt atcaaattcc tgctgaaaac gcagatatga gtttgttatt 3682501 ttttctgaca aaccttgcgc gattgacaag cagaagagat ttttcacata ataaatcacc 3682561 ataccttaca aaaaggagaa acggaatgaa cagcatcccc tctatcatca gcaagcataa 3682621 agcctatttt gcggcgggac atacgagacc gcttgaatcg agactgaaca ttttgcgaaa 3682681 gctgaaacaa gccgtcagaa ctcatgaagc cgatctcata gccgctctct accaggatct 3682741 ccataaatcc gagcaagaag catactcaac agaaatcgga atcgtcttgg aggaaatcag 3682801 ctttgtcatg aaacggctga gaaaatggtc caagccgaaa cgagtcaaaa cgccgttgac 3682861 tcatctaggc tccaaaagca tcatcatccc tgagccgtat ggaaccgttt tggtgattgc 3682921 gccttggaac tatcccttgc agctggcgct ttctccgttg attggcgcca ttgcggcggg 3682981 gaacacggtc gttctcaagc catcagaata tacgccggct gtttctgcta ttctttccaa 3683041 actcatcagc agcgtttttc caactgatta tgtcgctatg gcagaaggcg ggcccgatgt 3683101 cagcacagca ttattacagc agccctttga ctacattttc tttaccggca gtgtagctgt 3683161 aggaaaaatc gtcatggagg ccgccgccaa acaattaatt cccgtaacct tggagctcgg 3683221 cggcaaaagt ccctgcatcg tccataaaga tgctgacatt cagcttgccg ccaaacgcat 3683281 cgtcttcggg aaatttacaa atgcgggaca aacctgcatc gcaccggatt atttatttgt 3683341 ccacgaggac atcaaaacga agctcacaga agaaatgaag cgtgcgatca gagaatttta 3683401 cggccctcag ccggaacgga atccacagta cggcaaaatc gtcagtgagc gccactatca 3683461 gcggctgctc agctttctga atgatggcat cccgctcaca ggcggacaat ctgatcccaa 3683521 tcatcacaaa attgcgccga ccattctcga acaagtgaga gatgactctc cagtgatgca 3683581 ggaggagatt ttcgggccga ttcttccgct ctttacatac cgcaatatcg gggaagtcat 3683641 tgagaaagtc caatcgcgcc ctaagccgct cgccctgtat ctcttcacca caaacaaaga 3683701 aattgagcgc gctgttttag gaaatctgtc gtttggcggg ggctgtgtca atgatacgtt 3683761 aatgcatgtt gcgacgccgt atttgccatt cggcggcgtc ggggaaagcg gcatcggcag 3683821 ctatcacggg tttgacagtt ttaacacatt cacgcacaaa aaaagcgtcg tcaaacaaac 3683881 gaaccgtttc gacttcgcat ttcgttatcc ttcctccaaa aacgggctgc gaatgattcg 3683941 aaaaatactc aaataaaaaa gcgcagatca cctgcgcttt ttacaaatcc ttaatacacc 3684001 aatcaatcgg cgcctctccc attttctcca aataggcatt cgcccgggaa aacggtctgc 3684061 tcccgaaaaa tccgtttctc gcagaaaacg ggctgggatg cgtcgattca atgataaaat 3684121 gcttggaggt gtcgatccgt tcttttttca tttgagcatg ccgtccccac aaaataaaga 3684181 taaccggccg ctctctttca ctcagcacgt caataattcg gtccgtcagt cgctcccagc 3684241 cttttccctt atgggaattc gcctgtccgc gccttactgt cagcacagta ttcagcaaaa 3684301 gaacgccttg ctttgcccag ctcacaagcg acccgtgatt cgggatgctg cacccgatgt 3684361 cctgctgcag ctcaagaaag atatttttta acgaaggcgg ctgctttaca ccgggcttga 3684421 cagagaagct taaaccttga gcctgtcccg gcccgtgata cggatcttga cccaaaatga 3684481 cgaccttgac atcatcatat gatgtataat gcagcgcgtt gaaaatatcc cggctgtccg 3684541 gataaatcgt ttgctccgcg tattccctct tcagcatctc tctgagctct tgataatacg 3684601 gtttctcaaa ctcttccttt agctgattcc accagctgtc ttgtaaaagc tgtttcaaga 3684661 ttcaggcctc cttacgaacg atgaagtctg gaatagacag gctcgccatc ccaaaccatt 3684721 tcactttttg cttcccgcct cttcatctca ggctcttcaa gcaggacggc aaagtttttc 3684781 gtcggcagct ccccgagtcc gtgcttttca cttaaacgat ccaaatattg cttccgcttg 3684841 gcgccaaggt cagcagactg attgtctccc gcgtcactga aggcataaat cacgctggcg 3684901 caagggacac gcttcacccg gtaatccttg gccgcgcgca aataaaaatc ccagtcccag 3684961 taattgtgca catcagcatc gaaatacccg atttcatcat gcagaaaacg tctgtacatg 3685021 ctgcccgacg gcacgtatgt agaaaacact ctcatatcct catagtcagc ggtataagca 3685081 aacaatttcc gtgacactgg ataccttgtt ccgtttttct cttcaaacga aactatttcc 3685141 gcatcagaat gaacgaagtc tgccgtttct atttcctttg ccattttctc gatatgccct 3685201 ggcgtaaaga aatcatcgtc atcacacagc ataatgcaat ccccagacgc ctcttttaca 3685261 ccggcatttc tcgcagccac atgccccgag ttcttttcta aattgatgac agcaatcggc 3685321 agctccggat aaagtgcttt gaccggcacg accgattccc cggcatcatt cacaataata 3685381 atttcatacg gcatcaaggt ctggcgggaa atcgactcca aaagctcaca caaagccgga 3685441 atccgattat aggtcacaat tacgatagaa atcttcatga tgctctcctt ctcattttca 3685501 tagtcatgta ctattaaaac atatattgga cgggagatca gtgggaatat cctactgaaa 3685561 cggcatacta caatgataga aacagcaaag tggctccgat cagaagcacc atgatcagca 3685621 tcagatctcc aaagacatga aagatatctt tcatgcggac gccattcgga aggataagac 3685681 gccacagctt agattgatag accggcagca gcaccagtgc ataagaaaga cacaaaaatg 3685741 taaaagccgg cggcacaaaa gcacagcctg catcgtccca attcatcatg atgtctttca 3685801 tactagatcc atccaataaa aacaaagata tcatgagggc tagcaacaca aaggacccca 3685861 attgaacctc aaacaggcgc attttctggt tatatgcaaa tcggaccgcc caaaaccaga 3685921 cataagcata tgaacatagc agcgtaagaa tggcacctgc tgtaaagacg acatcaggca 3685981 gccgatcaag cagaaaaaca aaaggcaagc tggctgccat agccaagagc atgcagccac 3686041 cagtaaacaa aaatactgcc ccatgagcta caaaaccata taaacaagag ctaatcctca 3686101 cgacatacac ctcctttaca tagaaattct atgtatatac ctaaaaaatc agacaagctg 3686161 acgcctgcca atataacagc ccattcggcc aaataacgga aataacagcg ttgcaaaagc 3686221 acaagttcca acaaaccaag gtgtcaacaa ggattgaaac agcgcagcag gaattacatt 3686281 gaatagaaaa acaagcataa aaatgacgtt tggcaccatt gagatcagaa tcgtatgtag 3686341 aacaagcttt tctccgcgtt ttccaaactc cttcacgcct tgatacccaa tcagcaccca 3686401 gtagatcata tatgcagcta agatcagcca aacagaaaca gaaatgcctt tccatactgc 3686461 ttgaacaaac ggtgattcaa gccatacatg cattattgta atcgcaatgc cgacagcgaa 3686521 tagggcactg ttacagaaaa gatggaacat caaaaacgca cgaaacgtta ctggctgtat 3686581 tttcttaaac gaagaaacaa tgtcagttgg tgttccaaac gcctgcaata aagtctgcat 3686641 agcttcctcc tcactctttc cttcctgaaa agagcgaaac agatgatgtt caatatggct 3686701 ctcaatctct tctatcatcg cctcaccctc aggaagccct ttaagcccgc ttttgatttc 3686761 ggatacatat gtttctttat ccattttgtc cgctccactt cagtattcgg tccatcatgg 3686821 ctgaaaatac gctccattcc ttcgtgcgtt ccgccagcac ttctttgccc tcgtctgtaa 3686881 tccggtaata tttgcggtcc ggtcctttct cctgcttctc ccagtaggaa gaaatatacc 3686941 cttggcgttc aagcttgtga agagaaggat acaaggtccc ttctttcatc tgcagttcat 3687001 ttccgctgcg gcttcccatt tcttttacaa gctcatagcc gtacatcggc cgctcgttca 3687061 gaagcgtcaa taccaatata accgtgcttc ccttaaccag ctcacgattt aacatctcaa 3687121 aacccctacc tagttttctt atgtagcatt ttacgaaagc ccgttgagat tgtcaaatga 3687181 ttcctataga tcttctatat tgtgatacag agaaaatcta actataatga aagacaaaac 3687241 atgatggagg ttcaagacat gtctatgcat aaagcactca ccattgccgg ctcagattcc 3687301 agcggcggtg ctgggattca agctgattta aaaacatttc aagaaaaaaa cgtatacggg 3687361 atgaccgcct taacggtgat cgttgcgatg gacccaaaca acagctggaa ccatcaggta 3687421 ttcccgatcg atactgatac aatccgcgcc cagcttgcaa caattacgga cggcatcggc 3687481 gtggacgcca tgaaaacagg aatgctgcca accgttgaca ttatcgagct tgcggcaaaa 3687541 acgatcaaag aaaaacaatt aaaaaatgtg gtaattgacc cggttatggt ttgcaaaggt 3687601 gctaatgaag tcctttatcc ggagcacgcc caagccctgc gtgagcaatt ggctccgcta 3687661 gccactgtca ttacgccaaa cttgtttgaa gccagccagc tcagcggcat ggatgaacta 3687721 aaaacagttg acgatatgat cgaagccgcg aaaaaaattc acgcactcgg cgctcaatat 3687781 gtcgtcatta caggcggagg caaactcaaa cacgagaaag ccgttgatgt tctctatgac 3687841 ggagaaacag cggaagtcct tgaaagcgaa atgatcgata cgccttatac acatggcgca 3687901 ggctgtacat tctcagcagc cgtgacagcg gagcttgcca aaggtgcgga agtcaaagaa 3687961 gccatttacg cagcgaaaga attcatcaca gcggccatta aagaatcctt cccgctaaac 3688021 cagtatgttg gtcctacgaa gcattctgca ctgcgcctga atcaacaatc ataaaaaaag 3688081 gggctgcctt acagagaggc agcccttttt aaatcaccga agacttttca cagaaaaaac 3688141 tgccgatccc atcggcagcc tgtttatttg atttttaaat tgtttgcaga tttcctcaaa 3688201 aatgtttcta tcgactgaac aaaaagtgca tattccttca tttgttcata tgcccgcgtg 3688261 agaatttccg ccgtttcact gtgcggcgtt gttccgccaa gcattttttt cagctgaagc 3688321 agcacatcct tatattcttc tcgcttatct tcaacttggt tagcagcctt ttccaaacat 3688381 tccggtgtta tcttctgttc atgtatattc aagaaaacaa ctccttttac agaaaaaaat 3688441 agtaggttat cgttgaagaa tagcacagat ggctcagatt tcacataaga aaatagaagg 3688501 attttctaca taagtgtcca aattccgaca ttcatttcag atttcccggt cgcactggct 3688561 gttacttcat gatttcccgg gaaaggaaaa tatcttgcac tcaagacctc ttctccgtta 3688621 ttgataaaga tttccacaga tgacgcgtcg agaaacatgt gtacggtatg caaatccttg 3688681 atgcggcaat gtctcgcttc tgttcttttt ccgtcaaagc tctttcgttc cagcgtaaca 3688741 atcccctcgt ctttatggaa ggaaaacgta gccgttccgc ggatactgat tgaaaagcca 3688801 gactccgtat gaatgtcttc cagtagaatc tcagttcttt caggtttttc cactggaagc 3688861 gcaccagatg atccatgcat gttgatgtgt atttttttct catttctgcg catggctttt 3688921 agctcaggca gcggctgctg aatcagcttc tgtcctgaaa gcgtcagctg tctcggcagc 3688981 gtcatgcagt gaatccagtg gcagtcaatg gtcggatggg acccttcatc ctgatcaggc 3689041 accgccatcc atgcaaataa aatccgcctt ccctgatcgt cttcaagtgt ttgcggcgcg 3689101 taaaaatcaa aaccttgatc aagctccgta aattcaccat gcttcagttc aggcttgtta 3689161 taatcgaggc ggccgacaaa ataacctgat tgatatacgt tctgataacg gaaaccgtca 3689221 gcctcaagcc cttgaggcga aacaatcagc acatccgatc cttgaaggga aaacaaatca 3689281 gggcattccc acatgtatcc aaaatcgtcc agcccgttga agcccgcgcc ggttatcggg 3689341 ccaagaaatc tccactctgt caggttatca gaagcaaaca acacagcctg ccctttcaaa 3689401 ttctctgttt gcgcaccaat caccatatac catgtgcctt catgctccca taccttcgga 3689461 tcgcgaaaat gcgccgtata tccttccgga aggcgggcga cgacaccctt tttctcaaag 3689521 gacagcccgt cgtcagaaac agcaaggcat tgatacgttt cccgatttcc atcctgatcc 3689581 ctgacatttc ctgtgtaaaa aagatagagc cgatcgtctt tcgtgacagc gctgcccgag 3689641 tagcagccgt ttttatcaaa ccaatcactc ggagccagcg caatctcttc ccgcttccaa 3689701 ttcacaacat cctgtgtcgt ataatgcccc caaaattttg cgccgtgccc cgtctgaaac 3689761 ggctgccact gaaagaatac atgatagctg cccttccaat aaatcacgcc attcgggtca 3689821 ttcagcagcc caaccggcgg catgatatga aaatgctggc ggtgcggatc gctgttagcg 3689881 atgggctctt ttttctccac ttcttcataa gcccggcgac gaagctcctg gtcatgtgct 3689941 gtcatttttt cctctcctca tcctcattaa tcttcatgac aaatgctgca atgaacgctg 3690001 acactgccgc aatcgccatg ccaatcagat agtgaatcaa gttgctgaag ccaaacggag 3690061 ccgcaatggc gatcatcgga attcccgtta acccgtaagc gtttgcagct acatgtgtaa 3690121 agacgacata tgccccaccc aatgcgcctc cgatcatcgc ggcgataaac ggttttcggt 3690181 agcgcagatt gactccgaat atgacgggct cagtaatgcc gagaaaagcg gaaaatgctg 3690241 ccggaagcgc gatttctttt gtctttgcct ttttcgccat aaagaagacg gcaagacctg 3690301 ccccgccctg tgcgacattc gccattgacc agatcggcag caagtagttt ttgcctatat 3690361 ctgcaattag ccctgcctca atcgcatgga agctgtgatg aacgcctgtc agcacgatga 3690421 gtgaatacgt gcccccgaaa atcagacctg cgacaaaacc ggcatggtca tatacataag 3690481 ttaaagcaac cgtaatgccg gagccaagcg ctctgcctag agggccaatc gcgataaaag 3690541 caacaaaccc ggtgacaatc acagtaacaa atggtgtaac aagcaaatcc accgcatgtg 3690601 gaaccacttt tctcgtccat ttctctacct tgctcatcac atacaccgca agcaggacag 3690661 ggataacagt tccctggtag ccgagaagag cgatatcaaa tccgaaaaga tgcatgtaat 3690721 caggtgtcgc ttccgccaat ccccatggat ttaaaagatt cggatgaatc atgattcccc 3690781 cgatgaccgc tcccaagtat ggattgctgc caaactcttt tgaagcgctg accccgatta 3690841 gaatcggcaa gaaaatgaat gctgcacttg aaaacatatc aagcagctgc aaaagcgcag 3690901 aatccttgct catccaatga aacgcattga tcatacccag caatcccatt aataggccgc 3690961 tggctacaat agctgggatg attggaacaa aaatattaga aagcgttttc gcaaatctcg 3691021 cagcgggatt cagcttttct tttgccgcat cctgatgatt gacgtgttct tcacgctcga 3691081 tatcagcttc tttagaaaag gcatcgaata ctttattcac aaggcctgtt ccgaaaatga 3691141 tctggtactg gccagagctg ctgaaagccc ctttaacgcc atcaagctct tctacttgtg 3691201 cttgatctat ctttgattca tctttcatca ctaaacgcag tcttgttgca caatgagccg 3691261 cgctgataat attttctttc cctccgagaa gctcaatgag gcgttttgca gtctctttgt 3691321 aatccatcta tttctccccc ttttatttaa acaaaaaaga cctaaaattc gccaacgaat 3691381 aaaggacaca gcgatccttt ttcatttacg caaattttag gtcttgcctg ctttaccagt 3691441 cacaatcccg cttattcaga ttaagaatac gctttcatca taaatcatga tagcgttttc 3691501 gtcaactatt tttttagtta aatagtttga tataacatgt agacaaaaat tcgtaaaaat 3691561 taattgtgaa atacttcaca atatcgtgct atactatgct caatcatgaa agaaagcagg 3691621 aaaagacaat ggaaactcaa gcattacaaa aggttgaaca gtatgctttg aaaaaacaaa 3691681 acatattcgc ttcaagcaaa atccgttatg tgcttcggtc cattttggcc agtatattta 3691741 ttggttttgg cattacagcc gcaagcaaaa caggcagcta tttctttatg gctgattctc 3691801 cgtttgcctt tccggcagcc gctgtcactt tcggggccgc tattctgatg attgcttacg 3691861 gaggcggaga tttatttacc ggcaacacct tttatttcac ctataccgcg ctccggaaaa 3691921 aaatcagctg gcgcgacacc ctatacttgt ggatgtcaag ctatgccggc aatttaatcg 3691981 gcgccattct gtttgccatc ctgatcagcg cgacgggact ttttgaggag ccttctgttc 3692041 attccttttt gattcatttg gcagagcaca aaatggagcc gccggcttcc gaattgtttt 3692101 tcagaggaat gctgtgcaat tggcttgtgt gcctcgcctt tttcattcca atgtctctca 3692161 aaggggaagg agcaaagctt tttaccatga tgcttttcgt tttctgcttc tttatttccg 3692221 gctttgaaca cagcattgcc aatatgtgca cattcgccat ctcgcttttg atcgagcacc 3692281 ctgatacagt gacactgatg ggagcagtca gaaacttaat ccccgttacg ctcggcaatc 3692341 tgaccgcggg aatagttatg atgggctgga tgtactacac actgaatcct gatcaataaa 3692401 aaaacttcca gagatcactc cctgcaagtc aaagcggtta ttccgagaga tcttgaagac 3692461 gctggacatg cagcgtgata tagccggcct cggattccgg caaatgtaat tgatattcat 3692521 ttttcaaaaa ctccgccagc tccagcgcac attgataggc gaatgaatac tttttttgga 3692581 tgaaataaag catctcctcg tccatacgat ggagcgcttc atttgattcc aaccggctga 3692641 ccgcgtatcg caaatgcgtg acaaggcgtt gataggaaat gctgttttca tccacctttc 3692701 gattaaagta ttgttttatt ttctctatca tttctttgat catggtcgta tgcttcagcg 3692761 ctgaatacat gctctccgca tccatcttcg ccgtatggat gtgaagggca atataacccg 3692821 cttcatcttc aggcagagac acgcccaatg tctcttttac atgtccgatc gcccacaggc 3692881 cgatctcata ttctttttta tagagcgcct ttatctcatg cagcaattta ttctgcacaa 3692941 gcagcccatt ttgaatcctt tcgatcgcaa aggacaaatg gtcggaaagc gcgatatgaa 3693001 tgtgatcgct cagcggcgcc gcgagctctc cttccgcata gctgatgata tcctcagcta 3693061 tttctatatg ctcctccggc agtgtttgca ggatttgttt gaacttttca ttctcgtcgc 3693121 gcacgacaaa gatcttttcc actttattca tagggatgag atcatttttc tttttttgaa 3693181 aagcgattcc cggtcccatc acgatttttt cctgatcatc ctcttttatt aaagccgcat 3693241 tgttgtttaa tactttatag attttcaaga ggttatctct cccgccaatt tgcttttgac 3693301 tgggatttta cctccttttg accgccatgt aaagatgcgg gcccgctctc tcctgctttg 3693361 gcgattcctt gaaggcttgc aaacatcttc ttttataaag cgcggcggct ttcgctttct 3693421 gcttttcttc ctcattcaca gccatccgcc attcataaaa cgaaacgagt cctgcggcct 3693481 gcacagccgc ctttctttgg tatgtacgct gagccgaata gaccgcggca gccgcagttt 3693541 ttctgtccgg cgtcacccag ttcatcaaaa agaccatcca cacccgtaaa gatacaagca 3693601 aacgtttcat agaaaaacat ccctccgctt ctttttggca ggcagccttt ttagcagccc 3693661 gttttctcag ccgcagcccg caagaaaaga cggccgattt cttttctcgc aaactagcgg 3693721 ctctagcaaa actcatgact ctatgataga ccgtggaaag agaattcttt gtcacaatat 3693781 gagtgaaaaa accaactagt ttttagaagt tttgttgaaa gctgaaagaa ttgaaatgaa 3693841 aattggagaa ccgctttgaa aactttatac acaagttatc ccaaagataa gaacaactta 3693901 atcacaagag atatccacat gtccacaaac tctatctata ttttgtatac gaacgtatat 3693961 tcctaactat atatatacac aggtttattc acttatacac agggttctgt gtataactcc 3694021 ttcgttatac acaaacaaaa tccaataaat ggtccaaatg acacaaggat ttttttgaat 3694081 tttcaagaaa tatatactag atctttcaca ttttttctaa atacaaaggg ggaaacacat 3694141 tgaaaaaggg gatcattcgc tttctgcttg taagtttcgt cttatttttt gcgttatcca 3694201 caggcattac gggcgttcag gcagctccgg cttcttcaaa aacgtcggct gatctggaaa 3694261 aagccgaggt attcggtgat atcgatatga cgacaagcaa aaaaacaacc gttatagtgg 3694321 aattaaaaga aaaatccttg gcagaagcga aggaagcggg agaaagccaa tcgaaaagca 3694381 agctgaaaac cgctcgcacc aaagcaaaaa acaaagcaat caaagcagtg aaaaacggaa 3694441 aagtaaaccg ggaatatgag caggtattct caggcttctc tatgaagctt ccagctaatg 3694501 agattccaaa acttctagcg gtaaaagacg ttaaggcagt gtacccgaac gtcacatata 3694561 aaacagacaa tatgaaggat aaagacgtca caatctccga agacgccgta tctccgcaaa 3694621 tggatgacag tgcgccttat atcggagcaa acgatgcatg ggatttaggc tacacaggaa 3694681 aaggcatcaa ggtggcgatt attgacactg gggttgaata caatcaccca gatctgaaga 3694741 aaaactttgg acaatataaa ggatacgatt ttgtggacaa tgattacgat ccaaaagaaa 3694801 caccaaccgg cgatccgagg ggcgaggcaa ctgaccatgg cacacacgta gccggaactg 3694861 tggctgcaaa cggaacgatt aaaggcgtag cgcctgatgc cacacttctt gcttatcgtg 3694921 tgttagggcc tggcggaagc ggcacaacgg aaaacgtcat cgcgggcgtg gaacgtgcag 3694981 tgcaggacgg ggcagatgtg atgaacctgt ctctcggaaa ctctttaaac aacccggact 3695041 gggcgacaag cacagcgctt gactgggcca tgtcagaagg cgttgtcgct gttacctcaa 3695101 acggcaacag cggaccgaac ggctggacag tcggatcgcc gggcacatca agagaagcga 3695161 tttctgtcgg tgcgactcag ctgccgctca atgaatacgc cgtcactttc ggctcctact 3695221 cttcagcaaa agtgatgggc tacaacaaag aggacgacgt caaagcgctc aataacaaag 3695281 aagttgagct tgtcgaagcg ggaatcggcg aagcaaagga ttttgaaggg aaagacctga 3695341 caggcaaagt cgccgttgtc aaacgaggca gcattgcatt tgtggataaa gcggataacg 3695401 ctaaaaaagc cggtgcaatc ggcatggttg tgtataacaa cctctctgga gaaattgaag 3695461 ccaatgtgcc aggcatgtct gtcccaacga ttaagctttc attagaagac ggcgaaaaac 3695521 tcgtcagcgc cctgaaagct ggtgagacaa aaacaacatt caagttgacg gtctcaaaag 3695581 cgctcggtga acaagtcgct gatttctcat cacgcggccc tgttatggat acgtggatga 3695641 ttaagcctga tatttccgcg ccaggggtca atatcgtgag cacgatccca acacacgatc 3695701 ctgaccatcc atacggctac ggatcaaaac aaggaacaag catggcatcg cctcatattg 3695761 ccggagcggt tgccgttatt aaacaagcca aaccaaagtg gagcgttgaa cagattaaag 3695821 ccgccatcat gaataccgct gtcactttaa aggatagcga tggggaagta tatccgcata 3695881 acgctcaagg cgcaggcagc gcaagaatta tgaacgcaat caaagccgat tcgctcgtct 3695941 cacctggaag ctattcatac ggcacgttct tgaaggaaaa cggaaacgaa acaaaaaatg 3696001 aaacgtttac gattgaaaat caatcttcca ttagaaagtc atacacactt gaatactcat 3696061 ttaatggcag cggcatttcc acatccggca caagccgtgt tgtgattccg gcacatcaaa 3696121 ccgggaaagc cactgcaaaa gtaaaggtca atacgaagaa aacaaaagct ggcacctatg 3696181 aaggaacggt tatcgtcaga gaaggcggaa aaacggtcgc taaggtacct acattgctga 3696241 ttgtgaaaga gcccgattat ccgagagtca catctgtctc tgtcagcgaa gggtctgtac 3696301 aaggtaccta tcaaattgaa acctaccttc ctgcgggagc ggaagagctg gcgttcctcg 3696361 tctatgacag caaccttgat ttcgcaggcc aagccggcat ttataaaaac caagataaag 3696421 gttaccagta ctttgactgg gacggcacga ttaatggcgg aaccaaactt ccggccggag 3696481 agtattactt gctcgcatat gccgcgaaca aaggcaagtc aagccaggtt ttgaccgaag 3696541 aacctttcac tgttgaataa gaaaaagccc tgccgattcg gcagggcttt ttaaagatca 3696601 gtcagcaaac gcctcctgca ataagcgata cgatcggagc ttatcttcaa aatgatgcgt 3696661 gatggtcacc accatgattt cctctgtttc atacgcgtta ctcaaagcta acagccgctc 3696721 cttaacctgt tctttcgtac caacaatcat tcgatttcga ttatcagcaa ttcgtctctg 3696781 ttcataagga gaatacgtat ttttccgaac agcttcatac gaaggaactc cctctaaagg 3696841 aataccctgc tctcccgcca aaagtgtaaa atcaagcaca gccccaagct cctctgcctt 3696901 ctcctccgtg tcagcacaaa gaacaaaaac agcaactgcc gctcgaggcg tatctcctaa 3696961 cacagacggt ttgaatcgcc tcttatactg tctgacagta ccctctccgc cctctccatt 3697021 gataaaatgg gcaaacatat agccagcgcc agattcagct gcgagcagcg cgctttctcc 3697081 agatgagccg agcagccaca catccggagc cgttgaaata tgcggcgcag cggtcagatt 3697141 cggaaaacgg tgtttgtcat ccgccaaatc atgcaaatac atggtcagct ccttaatttg 3697201 ctgcggatac tgatcagcat tgcgcttacc accgtcattc agcgcccatg atgcaatcgg 3697261 cattcccccc ggtgctctgc caagccccag gtcaattctt cctggtgtca gcccctccag 3697321 aacacgaaag ttttcagcta ctttataagc actgtaatgc ggcagcatga ctcctcctga 3697381 tccaacacga attcgctttg ttttcgctgc tatatgactg attagcacct caggactgga 3697441 ccctgccagc cgttttgaaa agtgatgctc agaaacccaa aatctcttat atccaaggtc 3697501 ctcagcagct tgggcaagcg caacggtttg ctgtaaggcc gtttctgcat tgctgccctc 3697561 tgatactgga gattgatcta atatacttaa tgaaaccatc cctaccacct catcctcatc 3697621 gtatcactga tcccctattt tttctccaaa gccgctcaca ctgcttatca gtgtccccta 3697681 tcattcgcca tttatttgtg aaagcatgtc cctatttgtc ggaatatgtt acacgtgaaa 3697741 cataaaaacc cctccagacg gagaggtttg ctttagtttt tattaaagcc cttttctttc 3697801 acgtagtcat ttaaatacgt acgcggcttt tgcttcataa agttcagtat ttgatcggac 3697861 cacgtttctt cccgcttccc gtttgttctt tctctatagt aatcagaaat ggttttgtca 3697921 tacgtattca tagtatgacg gaaatcgtct gtgttcacat tatacgtatt ttcatgataa 3697981 acggcctgct ttggcaatct cggttttttg ccggaaaggt tcgcaggatg gcctactgcc 3698041 agtccgaaaa gcgggagcac atggtcaggc gtttgcagca cctctgtcac cttgtccaat 3698101 tcattccgaa tgccgccgat atagcaaatg ccaagcccca tggattcagc ggcaatgctc 3698161 atattttgcg ctgccagcgc cgcatcaatc aagctaacca taaacatttc tgtattctcg 3698221 agcagctcag aaatatgttc acctttttcc tcagccagtt gttgatggcg gtacaaatcc 3698281 gcacaaaata caaaaaagtg tccgttcttc tcaacgtaag gctgattccc agcaagcacg 3698341 gacagctcac gttttttctc aggatcagaa accccgataa tcgaatatgc ctgcacatag 3698401 ctggatgtag acgcagcctg cgcacttttc actaatgtat caatttcttc agctgtcaaa 3698461 agctgatcag taaaagaccg gattgaccga tgattcaaaa tggtttcgat tgtgttattc 3698521 atcacaaaaa cctccttatc actttttatc atatccgaaa aaaagtgatc tcaaaagtga 3698581 aatgctctgc acaaaaaaag acagcctctg taaaggctgt ctgcatatca agaattaaaa 3698641 agataacttc tgtatttcgt cagctgcaca cttgcattat atacaatccc aaatccgatt 3698701 aacgtggaaa gtgtcgagct tcccccatag ctgacaaaca gcagcggaat cccggtaaca 3698761 ggcataatgc caatgttcat tccgatattc tggaatgtgt ggatcacaat taacgccgta 3698821 tagccaacgc aaaagaaaga agcgaaacgg ttaaacggat gtattttgtc tatcagaaca 3698881 acaagcctgt agattaaaaa gaagaacatg atgacaacaa ttgcacagcc tataaagcca 3698941 aatgactcac ctattataga aaagataaag tcagtcgtac tctctggaac ataaaccttc 3699001 aaattagaaa taccattacc taaaatacca ccagatccta ttgccatgat ggcctggtca 3699061 acttgccagc tgtcatttga atcttcctgt gtctcatttg aagcagacac ccaagaagtg 3699121 acccgcttaa tttgataatc ctgtattcca actgatttag caacgtcagg aaagtttatc 3699181 attactaata aaattaatga aatgagtaag atacctgaac cagctatgat cgcaatcaat 3699241 ttccaattta tccctgacat aaaaaccatt acaagaacga taaacataca tattcccgca 3699301 gtcccagcat cctgcatcag gataagacct acaggaataa ctgcgacacc cgcaatcttt 3699361 aataacaagt ggatatcatc cctaagcgtc cgaactcctt taggatttgc ttttccaata 3699421 actgaagcaa gcatcataat caaaccaacc ttcataaact ctgacggctg tattgttatt 3699481 ctaccgatcc taaaccaact ttttgcccct ttaataacag gtgcaataga ctcgggactg 3699541 attttaagaa taatcaaaga taaaatacca atgataaaaa tatataaact taacttttca 3699601 agctgttcta aatcaaagta caaaagaact gtaatggcta cagcccccaa aagataaaac 3699661 acaatttgct gaatccaatc cgtgttccca tactgcccaa actgaccggc agcatatatt 3699721 gatactacgc ttataataaa aaacacacca aatataaaaa tcaaatcccc ctggtaaaag 3699781 gggctttgct gtttcttata tcgactcatt ctatcccgcc ttacattttc atcggaaaat 3699841 cactaatgtt tattatacat gaaccacgtt caagatgaca cgtgaagctc gcttcctttt 3699901 atgttttttc agcatttgcg gcgctttttc agctacacga aatatgacgt atcataaacc 3699961 gaaatgtttc gattgacaca aaacttttca aatgaaaaaa acgccatacc aatagaattt 3700021 gttaaaaaac gaatgcgata atgtgttatg ttcccaaata atgtgatacc tcatatagaa 3700081 atagctaaaa attcagagcc ccatgcccat acattctcct agcacattaa acgaaaaaat 3700141 aagacgatag atccagtcca tttctgcaaa aacacgtatc aatttctgga aaacatggta 3700201 taataattgt aacagaatgt tcaaaaaaca atcacaaaac agacacaact cagttcctct 3700261 atttcatttt tgtaaacgtt atcacaaaat gaaaggagac gggtatgatg gacatgtttt 3700321 ttgcttactt attggttgcc agcgcaacgc ctctctttat ttggcttgat aacaaaaaag 3700381 tcgcactctc agctattccg ccaatcattt taatgtgggt attcttcttc ttttacgcaa 3700441 cagaaagcct ttctccactt ggacacactc tcatgattat cttgtttgcc gttaacgtca 3700501 ttgtcgctca tatcgccgca tttatcattt acggccttcc gtatcttcgc agaaagcgaa 3700561 gcagctgaag acagcaaaaa accctcttcc actgaagagg gttttttgta ttattcgtta 3700621 tggcctgaat gctctgagtg ttcagcgcct ccaggaggat ttccgtccat atggtcacca 3700681 tggtgatagt gagccgcgaa aatccagatg gatccaagta cgataacgat cgcgccaaag 3700741 aatccgaaca gcgtgtttcc gacttggatc gtgccgtttt cgctctctgt catatgcatg 3700801 aacatgagaa gctgcagcgc cgcctgaatg aaggcgaagc cgaagataat ccaaagtttt 3700861 gctgatgagc tcaggtcagt atacactgca acccatagag ccagcagggt caaaacgata 3700921 gacaggataa aacctacaat gtgtttccat ggaaagtgac tgtgttcagc agatttgttt 3700981 gccattttac agacccccca atcccatgag atagacacct gtaaagatga aaatccatac 3701041 aacatctaag aagtgccagt acaagcttga gataaagatt ttagatgaag tttgcggagt 3701101 taagccgcgt ttcttcaact gaatcagaat tcctgtgatc cagaaaatcc cgattgttac 3701161 gtgagttccg tgagttccaa gtaaaacaaa gaatccagac cagaacgcac ttgtactgag 3701221 agccgctcct tcatgtacat agtgaacaaa ctcgttgatc tcgcatccga cgaagccggc 3701281 accgagaaga agagtgataa ttgtccaaat gactacgcct tttaaacttc cgcggcgcat 3701341 ttcatgaaca gcgatcccgc aggtaaagct gctgatcagc agcaagaacg tcataatcat 3701401 taccagattg acttcaaata gttcgtctgg caagacacct ccagctgttc tgtttttaag 3701461 aacgaagaag gttgcaaata gtgttgagaa caacacaatt tctgccccta aaaagatcca 3701521 aaacccgaga atattaagtc tgccggtttc agattgatat tccataggcg cgttagaatt 3701581 gccgtgttct gcatgttcca taactcacgc ctccttattc ggaaatcttt ctttccgtct 3701641 cttttatttc atcaacacta atgtagtagc cgttgtcgta ttcgaatgaa cgcagaacca 3701701 tgcagagcag gactccgatc aatccgacta cgcccatcca gtaccattca aagacaagtc 3701761 caaagcctgc gagaccgaag gcaacagaca taaagaacgg tctgcctgag ttgcttggca 3701821 tatggatttt cttgaatttg ctttcagggt ataattcagt tttttcttct ttcatatgca 3701881 ggaatgcatc ttgagatttg acttcaggaa gcaccgcaaa gttgtaatgc ggcggaatcg 3701941 cagaagaagt cgcccaatca agcgtacgtc ccacacccca tgaatctccg ctgatttcac 3702001 gagtagagta acggaagctg tagtagatgt tatagcaaag gattaagaat cctacaccca 3702061 tcatgaaagc tccgactgtt gagataaagt tcaatgttgt ccagccgtca ttcggtccgt 3702121 atgtgtaaat acggcgcggc atgccttgaa gccccaagaa atattgcggg aagaaacaaa 3702181 tattgaaccc gatcataaag atccagaaga accattttcc gattctttcg ttcagcttgt 3702241 ggccgaacat ttttggatac cagaaaataa atccggcgaa acaagcaaat acagtacccg 3702301 caatcagcac atagtggaag tgagatacaa ggaagtacgt attatggtat tgataatccg 3702361 ctgctgccat cgcaagcata acccctgtaa ccccgccgat aacgaagtta ggaatgaacg 3702421 caagcgccca cagcataggt gttgtaaagc tgattcggcc tttatacatt gtaaagagcc 3702481 agttaaagat tttaaccccg gttgggattg agattgccat tgtcgtaatt gagaagaatg 3702541 agttaacgga cgcactgttc cccattgtga agaagtggtg agtccaaact aagaaactca 3702601 atacagagat ggcgataata gaaccaacca tcgctttgta accaaacaat tgttttcttg 3702661 caaagcttga gatgatttct gagaaaatac caaacgccgg aagaataacg atatatactt 3702721 caggatgtcc ccaaatccag aacaagttag cccaaagcat cggcataccg cctgcttcca 3702781 atgtgaaaaa gtgagcgccg aacaaacgat caaatgataa aagtgctaat gctactgtaa 3702841 gtacagggaa cgcaaacacg ataataacca ttgtgatcag tgttgtccat gtgaacatcg 3702901 gcatacgcat taatgtcatg ccttttgttc tcatttttaa gattgttacc ataaagttga 3702961 tccctgtcat cagggtaccg ataccggcaa tctgaagtcc gaggaggtag tagttctcac 3703021 ccggcccagg gctcatgtcg ttacttgcaa gcggcatata actcgtccag cctgcgttcg 3703081 gagaacctcc gataacgaaa gaaatattga aaagcatcgc ccctacaaag aacgtccaga 3703141 agctcaggtt gttcaagtaa gggaacgcaa cgtcgcgggc accgatttga agaggcacaa 3703201 caacgttgat aagaccgatt aagaacggca tcgccatgaa gatgatcatg attgtaccgt 3703261 gagttgtaaa aatttcatta tagtggtttg agtctaaaaa actgttattc ggaagcgcta 3703321 gctgggcacg catcatcaga ccgtcgacac cgccacggaa taacataatt acagcagata 3703381 taatatacat gattccgagt tttttatggt caacagtagt tatccattca gaccacagcc 3703441 atttccactt tttgaagtaa gtcagaacaa aaataatggc aatggttgaa agcgcaatgg 3703501 aaacttgtgc gcccagaatt aatgggtcac cagttacgaa aaattcgtcc catttgaatt 3703561 tcatgcaggc ttcctccttt cctgatcaat atcattcttc tgtatcatca gacttcttaa 3703621 attcgttttt ctttacgttt tcaaacggat ctgttttaga atgcggtgaa acggcttgat 3703681 agccaaggcg tttgcgcgcc tccatcgcgt actcagcgtc ttgtccgtga tcaacgtatt 3703741 tcaagtgagt agaagagaac gttaattcgt ccacattttc aggaagcatc aattcatcat 3703801 acttctcttt tgtcagctta ggagcctcgt tctgagtctt tttcacccag ctgttaaagt 3703861 ctttttctgt gactgcattc acatcaaact cttggtctgc aaaatgttca cctgtgaagt 3703921 tcgcgttgcg gccttcgtaa gtacccactt tgtcagcctg taagtattga tccatcagca 3703981 ttcctgccat cgcatatttt tgccctccaa gctgaggaat ccatagcgaa gccattgaat 3704041 ctgcagatga gattttgaac aagatcgggc ggtcgacagg aatgtttaag tagttgaccg 3704101 tttcaatatc ctgttcaggg tagctaaata cccatttcca gtctaccgaa gtagcataaa 3704161 caacaagagg ctctttgtct tttgttgctt caggagcttt ttctaacgaa tatatcgtct 3704221 gtactgttgg cacagaaagt gcaatgacga ttaaaattgg gatcactgtc cagactactt 3704281 ctaaaaacgt gttaccgtga atttctgggt tataagatcc attatctttg cctttacggt 3704341 cgcggtattt tactaaaata atggtaaata gaacaaagac gaccccgacg ataaacagca 3704401 taaatccgat agataacagg attaaatcac tttgctgttc agctacaggt cctttcggat 3704461 ctagtactga agcattgctg catcccccaa ggacgaaaac cacagttaac agcgctaata 3704521 caagcaacgg ttttaatgct ctgaacaaga agatcaccat ccttcctatt gatgtaataa 3704581 atctgaagtg catacttcct caaaatcttt tctctacttt gttatgctat caaaaacttc 3704641 acttattagc tttatttttt tataaacttc atcccatttt cgcttaaatg tcataaaatc 3704701 gacaaaaatt gctccaactt tattcacatc tatcgcttaa gatgaaaagt ttctagttat 3704761 ttccgcatat aaagtaaaga aagatgatga agaactaatt ctgacaaatt aaggtttacc 3704821 acaataaaaa acttaggtca atcaaaaatt tcattttgtt aaactttcta gataggaatt 3704881 attttttcct cgtctagcat cttttcacac ggttaccatt ttaacgcatc aaatattgaa 3704941 agaaaaggcg caatgaagag ccaatatgct ctgaattgtc cgtatttttt tatgagagca 3705001 tccagttgtt tatcttatac aaaaaagagg aatgatataa gcaaataaat aaaaaatagg 3705061 atgtgttgca tgatgagttt tcttatttca cttatcgtcg ctattattat cggatggctt 3705121 ggaagcctgt ttgtaaaagg agatatgccc ggaggaatta tcgggtctat gatcgcaggt 3705181 cttataggcg cctggatcgg acacgggctg cttggaacat gggggccgca cctagccgga 3705241 tttgccatta ttccagcggt aatcggcgca gccattgttg tctttctagt aagcctgtta 3705301 accagaaaaa gaggataaaa gcagcagcac ccgaagcgtc agcgctttgg gtgtttgttt 3705361 tgccataaaa atcgaaaaag cctcaaccct agcggttgag gcttttgact ggtttggcgc 3705421 ccaactgatc gatgaacctt ctgaaggcct gttttccctc tgctgtctgc ttaaatacac 3705481 cggcgtgttc aaggatgcgc gcgaatacat gtcccagctc ttcttttatg actagatcta 3705541 cgttctcttt tgttatggtt cttttttcca tcgtccgaag agcccactca ctatgctttg 3705601 cagtgagcgg attttgttct aaggctgttt tcggatcagc agaacatagc gccgctgccg 3705661 tttctttcat ttcctcctgt aagcggccag gcaatatcgc caatcccatg acctcaatca 3705721 ggccgatatt ttctttttta atatggtgga cttcttgatg aggatgaaat attcctaatg 3705781 gatgctcctc atccgtccgg ttgttcctca gtacgatatc gagttcgtac aagtctcccc 3705841 tgcgccgcgc aatcggtgtg accgtattat ggggcgtatc gcctgtatag gcggcaatgc 3705901 cggctttttc atcggaatac gtctgccacg tgcggaagat atggtcagca gcttcggcga 3705961 catgacccgg ttcgtctcct tggagcctga gcacagacat cggccacttc actaagccca 3706021 gcgacacgcc gggataatca tttaattcat aaacgtcttc cgcttctgca cgtgccattg 3706081 gaaaatcatg cgcgccgcct tggaaatgat catggcttag gatgctgccg ccgacaatcg 3706141 gcagatccgc gtttgaaccg ataaaataat gcggatattg gccaagaaat gacagcagcc 3706201 tttcaaatgt ttttttgctg atctccatcg gttcatgttc accttttaag acaatgcagt 3706261 gctccggata atagacatat ggcgagaatt gcaggaacca ttgttcgtcc tcaaggatga 3706321 ccggaatgat tctgtgattt tgccgggctg gatgattcac gcttccctcg aagccgacat 3706381 tttctttaca cagcaaacac atcggataat ttgtctgttc ctgctctttt gcagccgcaa 3706441 tcgctttcgg gtccttttca ggctttgata ggttaatggt catttccagc tcgccatatt 3706501 cggtcggcac cgtccaatga acatttttgg cgattctgtc agtccgtata taatagacat 3706561 cctctgaata ttgatagaat tcctttgtcg cctgttttgg gccgtataat gcttttgtct 3706621 cttcaaattt gcgaatgacc tcggacgggg caggcacaaa acagcccatc agctttgcgc 3706681 tgagcaggtc acggtacgta tctgtatccg cttccattcg gccggtttcg gcagcccatt 3706741 tatagatggg agctagcaag tccggcaggc tttgtgactg cttgatgctg gtgctggagt 3706801 tcggctcggg atgtgtgatg cccagcgctt cataaagacg gtttctcgta tattcccgat 3706861 cccagatcga aatcaatttt cgttccaggc catactcaag cagctgttcc agatgttcaa 3706921 taatactcat atgtcactcc ccctttagtt ctctcgctcc ctctccgata tccgcgacat 3706981 aaaagtccgc tcggagccct gttttttctt gatatctgtc tccaaccttc tgaataaaat 3707041 catcaacgaa ctcatctttt acaatgctga tggtgcagcc gccaaagcct gctcccgtca 3707101 ttcttgatcc aattacacct tcgtgatccc atgccgcaaa cacaagctca tcaagttcag 3707161 ggcatgttac ttcatagtca tccttcaatg aaaggtggga ttccttcatt aactgcccga 3707221 tttcatctat attgttctct ttgaacatat gggccgtctt aatagcacga tgattttcgt 3707281 atacagcgtg ctttgcccgg cgtctgttcg tttcattttg gatcaggctg gaatgcgcat 3707341 cgaaatcaga aggcttgatg tcgcccagtg cggcaatatc gaggcctttt ttcagatcaa 3707401 gcaatgcatc attgcattct tggcgtctcg tattatagct ggagtcagcc aatgtccttt 3707461 ttttgttcgt gttcgcgatg accagcgcga ggcctgagac attgagtttg ctatattcat 3707521 agtcaagcgt gtcacagttc agcagcatcg catgatgttt tttccccatt ccaattgcaa 3707581 attggtccat aattccgcaa ttgacgccga taaaatggtt ttccgcatgc tgcgccattt 3707641 tcacaagctc aagcgcatct acttcaggat gaaaataact ttggagcacg acccccatca 3707701 gcagttcaat agaagcggaa gacgacagtc ccgccccgtt tggaatattc cctgaaaata 3707761 caatgtcaaa gccatgggga actgcatatc ccctctgttg aaattcataa atcacgcctt 3707821 ttgggtagtt cgcccagtcg tcttcttttt gatagcgaat gtcgtcaagg ctgcattcct 3707881 tgatgcctgc gtttctaaag ttatctgaat acatccggac aagcccgtcg tttctttctg 3707941 caacagcagc atatgtaccc attgtcagcg cgcacggaaa gacatgcccg ccgttatagt 3708001 ctgtatgttc tccaatcaga ttcactcttc caggtgcgaa aaaaaaccgt aacccctctt 3708061 tttctccgaa tacacttgca aatatcccct ttagctcttc ccgcatgtgc aatcaccttt 3708121 ctggttttta ttttttattc cccttatttc ttcatagaaa acggcagatc atatgctgca 3708181 gtcctctcat accccttctt cttttgtttt tttaaagacg agccatttgc tcgcaacata 3708241 gttgacgaca acaatgaccg cgttgtcgag tattttggcc aaggtttcat ttgtattgaa 3708301 ctggccgaca agaatgatca tcatgcctaa atctatgccg agagacagga cccgaacgct 3708361 gaaaaaagca gtgagctctt tcagcaggct ctgcagatca tgtgtttttt gctgaaacac 3708421 atataattta tttgttatgt aagcaaacag cacggacaaa atccaagcgg caacagtggc 3708481 ggctttgtaa tccacattca tgatctctac caatatataa aagctggcga tattcacaat 3708541 ggttgtgaaa acccccataa tgatatacat aattatttct ctatacttca ctgatgttcc 3708601 tcgctttctg aaaaactttt caaaattctt ggcctctcgt gctctctgtc taaagtaaaa 3708661 aataccgaga gtgcgtctaa aaagctgcgg aaggtggctg gctggcccaa tacatatgat 3708721 tgtttgatga ttccgtcgag gactgcacat attattttag ccgtatattc aggatcaata 3708781 caggcgtcaa tcagctttct ctccttcagc cacttaatat ataacacatt ttcttccacc 3708841 cacaattcgt acagccggac ataggccttg catttcttta agactttata tgtcggcatg 3708901 ttcatggcaa acgaggtgat gtcccacgac ggcttattta tgtaatagga ataaagcagt 3708961 tctgcagcgt gttttgcagc ctcgtccaat gtcagcgatt tcactgactc ccgctccatt 3709021 tgatcaagat accctataat gatctttttt ttcatctgac gtttttcgag aaggtacagc 3709081 agaaaatcgt ccttgctgac aaaatgaaca taaaatgctc ctttgctgta cccggcggct 3709141 ctgctgatat cttctacaga aaccggatca tacgctcggt caatcaacaa attcacgcca 3709201 gcgtctataa aactttcaaa tgttgcttct cttttaattt gaaatttgtt ttttttcata 3709261 tttttctcct ggcggtaatg attaccctta tcttacaccg gatcaatctt tagcggtatt 3709321 tatttcttta aacggttatg ctattcggtt tcccaggggt catttttaat aggctaaatg 3709381 atttattttc atttacatac tatccagtca gtatttaatt gtttattatt ataaataagg 3709441 tccattggtt atattagtca tttttttagg gaataggtag gtggtttttc cttcagtttg 3709501 tgaacaccga gcaactatgt gtgaaatttg ttgtactcgc ctccatcatc gcgctggctt 3709561 gtcttttatt gcccgcatgt tgcaggaaaa cattttatac aattggaggt tactatgaaa 3709621 actcatgtta aaaaagattt ggacaaaggt tggcatatgt taattcaaga agctagatcc 3709681 attggattag gcattcatga tgtgaggcag tttttagaat ctgagacagc atcaagaaag 3709741 aaaaaccaca aaaaaaccgt ccggcaagac tagtccgaac aggcggatct atttacctct 3709801 ggcttttcta tcacctgatc tgagttttca ccatatcctc tattcaaaag caaatcgctg 3709861 cgctgagctt gaggacaaac ggtgtgtcag ctaactacga cagacagccg gtgatgcgat 3709921 cacctcttgg cacatgcatt gtcataaaga ggtgatgcga acatgataac cgtgctctgg 3709981 taaacagcag ctttgctgag aacaagctgc attcggtgag gttttgaaag caaactcgtt 3710041 tatacacggc cgagcttgaa aaccttcgcc tgtctttaga ccactgtgtt cacctcttca 3710101 cgacttcctt cttttttcat cctccagcta ttgtacaacg cataaatcgg actttcagta 3710161 catacctatt ggtgtacctt tttgcttacg tttagcgaat aaaaggagga aagccatgta 3710221 caaagctgat tataaacaga ttgctgcaac gccgtctttt caagcttttt taaagcagaa 3710281 acgcgctttt attgttcctt ctgcgatttt cttttttgtt ttttattttt cactccctgt 3710341 tttgacatct tatttcacct ttttgaatgc accggccatt ggagctgttt catgggcttg 3710401 gctgttcgcc atcgcccaat tcgctatgac ctggatactg agtactgtgt attcccggag 3710461 agccgcccat ttcgataagt atgtaagcgc tttaaaagag gatctgaagg gtgaacagac 3710521 atgaatatga ctgctttttt attatttttg gcgattgttg gcctgacgct tattatcacg 3710581 tattttgccg cgaagcggac gaaaacgacg agtgagtttt atacggcggg cggcgggctc 3710641 accggcgttc agaatggact ggcaattgcc ggtgactaca tgtctgccgc ctcgtttctc 3710701 gggattgccg gaatgattgc gttatatgga tttgatggct tcttttacag catcggtttt 3710761 ctggtggctt atctcgttgt cttgtacatc gtggcggagc cgcttcggaa tcttggaaag 3710821 tacacgatgg cagacatgat tgccgctcgc tttaaagaaa agaaaatccg cggtgtcgcg 3710881 gctctcaata ccattgccat ctctactttt tatatgatcg cccagctcgt gggggcgggc 3710941 gcgctgatca aactgcttct agggctggat tataccgcgg ctgtcctcat cgtcggagtg 3711001 ctgatgacca tttatgtcgt gtttggcggc atgatcgcga caagctgggt tcaaattatt 3711061 aaagctgttt tgctgatggc cggcacactc gtgatttcga ttatcgtgtt ttcgaaattc 3711121 ggctttagcc ttaataccat gtttgaacag atgaaaacgg ctactccgct tggcgctgat 3711181 tttttgaacc ccggaaataa atacaaggtg ccgcttgaga ccttgtcgtt aaacttggca 3711241 ctcgtgctgg gaaccgccgg gcttccgcat atattgatcc ggttttatac cgttaaggat 3711301 gccaagacgg cccgtacatc cgttgtgtca gcgacatgga ttatcggtgt gttttacatt 3711361 atgacggtat ttctcggctt tggtgccgcg gcatttgtcg gttttgacgc gattacggcg 3711421 gctgatcaag cgggaaatat ggcggctccg cttttagcaa aagcgctcgg aggagacttt 3711481 ctgttcgcgt ttgtatcagc catcgccttt gccaccattt tggctgtcgt gacagggttg 3711541 gtgctgtctg ccgcctcagc atttgcccat gatatttaca gccagatcat cagaaaggga 3711601 gaagcaactg aaaaagaaca aatgaaagcg gccagatggg cttctgtcgc cgtgtcagtg 3711661 ctctcgattc tccttgcgat ttttgcacaa tccttaaatg tggcgttcct tgttgcactc 3711721 gcgtttgcgg tagccgccag cgcaaacctt ccgctgattg tgtttacagt cttctggaaa 3711781 cgattcaatg cctcaggcgc tttatggggc agcctgacag gcctgatcag cgcgcttgtg 3711841 ctggtatcga tgagccctag tgtgtgggac ccggccggag gtgctatttt taccggtgat 3711901 ccgctcattc cgctatctaa tccaggaatt atttccatcc cgctcggctt tctcggcgcg 3711961 tggctcggaa cggtgctgtc gtctgataaa acaattgatg aagatacgtt tgcagaaatt 3712021 caggtgaagg cgcatactgg cgtccatatg gaacaggaat aaaaaaagct ctctttatcg 3712081 agagcttttt ccttactttt tcttctgctc gtcagaaatc gctttttcaa atacatcctt 3712141 gccggcagca cccggaatta cagtgtcacc gataataaag gttggaacgg ctgtgatgtc 3712201 agcctcttca taggcgtgct tcaaggcttg gcgctgcacg tcctgatatg ttcttgtttc 3712261 cagtgctgat ttgaatgatg caccgtctaa tcccacttcc tcggcgagct tcgtcaagat 3712321 gtcaatatcg ccgatatttt ggtcctcctg gaaaaatgcc tgaaagacac gggtgttgta 3712381 ttcatgtcct ttattgtatt ccttcgcaaa atggaagcct tcaaacgcga ggtctgtata 3712441 cggatggggc gagacgtttg gaaaattgat ctcgactcct aatttctccg ccattggctg 3712501 aattgatgtc tgccacatgt actgtttaga aggatcattg accggatcaa gctgaggaga 3712561 tgggcttggg cgcagttcaa acggcatcca ctcgacttca acatcctttc cttttatcgc 3712621 ttcttcaaaa gcggcttttc caacaaaaca aaatgggcag acgtaatctg aataaacttt 3712681 aatgtgtact gtcatgataa tctcctttca tactaaattg attttaaact gtaacaatta 3712741 aagttacaac tgttttttaa taaagaagcc gatttaggct tctttcagat tgatgacaaa 3712801 atcctaaaaa gttttaggat tttgtcatcc tttcagcgtg attgaaaacc cttgaagtct 3712861 aggaaagccg agcattggag cggagcgaat gctctaattc gtgagcacca acgcacaggc 3712921 ttgacaacga atgcgagggt ttgtcgacac gctgaaagaa gcctgtaaag gcttctttta 3712981 tgattccagc aaacgctggg caatatattc tccttttttg cagccgcctg ggcatgcgta 3713041 taaagcagaa ccgattgttt gtgtatattc gtttaacgca tcctttgctg aaagagcctt 3713101 cagcatcggg ataaactgat tgtcgggatt tttttgaaaa ctgataaaca ggagacctgc 3713161 atccatatag ccggttttcg gatcaagtcc ttctgtgtaa gagaaagctc ttcgcaaaat 3713221 ttgtttccca gtagatttcg ctagactgac gtgtgaatta gacggaattt gattcagctt 3713281 cacgggatct gtttcctttt tctgcccaaa aggcgccccc gagctttttc tgcggccgaa 3713341 ggtatcctct tggtccttga gggaagagcg gtcccatacc tcaaggaaca ttttgatttt 3713401 ccgaaaagcc atataggtgc cgcccgtcat ccagtcaggc tcaccagact gaatccacac 3713461 gatcgagttc atcaacgtgt catccttcgt gctctggttg cctgttccat ctttaaaccc 3713521 gaagaggttg cgcggtgttt caccattttt tccaccgctt aaaaagcctt tgttcacaaa 3713581 acggacctca caagtgccga ccgcttgatt tagcaggtta cgcagcgcgt gaaacgccac 3713641 ttgctcgtcg tctgcacaca cttgaatgca gatgtccccg cctccctgct tttcatccag 3713701 gttgtcattg ggcatcgctg gaagagcggc taggtgcttc ggttttttgc ttttcagtcc 3713761 gaagcggtcc tttccgtctt tttcaaaaaa gccaggcccg aatccgaatg tgaccgttaa 3713821 gttggaaggg gataaatcag cagactcacc tgtatcctgc ggcggcagat actgatttct 3713881 ctgctccgct gacattttct tgccagacgt cagcatctgt gtgagacttg tccagtttct 3713941 aaataacgta atgatgtcgc ttttgtcttt tgctgttaca tccagtgcag caaaatagac 3714001 atacgtctga tgggcagttg tgattccggc ctgatgcttt ccgtaaaacg gaacaatctg 3714061 ctcctcctct ttttcatcct ttttcgatgg cttagccgca gtctgaacaa gcggagcgag 3714121 accgccgaga ccgctggcac cgatcgcaac ggctgccccc gccatcgctc cccattttaa 3714181 aatgtcccgt ctgtgaattt gttctggctt tttctgttca tcgctcatga tgttacaaaa 3714241 ctccttttat agcacattcg caatcttcga catggtttca gaaagagtcg tcagcttagt 3714301 gctcagctct ctgatttgct tttcacttaa tttatcataa gacgtatagg actgatcatt 3714361 tgttttgtat tttgccatta aaacttcaaa ttcgctgaac tccgtatcca gtttttccgt 3714421 caagtcggag tgatctttta caagcgcgct tttcactgtt tgataaacgg cttcggagcc 3714481 ttccacattt gccataaggt caactaaatc aattcgtgag tagcgctctt cttctcccgt 3714541 gattttcgaa attccggctt cgttcagaag ctccatcgcg cctgcaacaa tttgttcagg 3714601 tgttaatttc agtgattgaa ttgaaccgtc aagctctttt acatccttga gaagctggtc 3714661 agctgttgcc ttttccccgg aaatatcttg atccttccaa atggccttct caagcttatg 3714721 gaagcctgtc catttgtctc cttcttcaac atcgttttct cgtgcgtcaa ttttcggatc 3714781 aagatctccg aggctttcag cgatcggttc gattcgctcg taataaacac gcgctttcgc 3714841 atataacgtt ttggactttt cgatatcgcc ggatttcaca gcacccgtaa atgcttcagt 3714901 cgctttgaca agctggtcac tctgctcttt gacatagcct ttatactcat ccgctgcttt 3714961 tgccagctga tcgctagcct ttttgccgct cttcttcgct tctgtcaggt cttctaagga 3715021 tgctttcaat gactcggatt ctgtcttgat ttttcctgca tccggtttgt ctttttgcgc 3715081 ttctgtgtag attggctgaa gatgcttttc gatttctgta tattcgaatg gatagtcgct 3715141 gcgaatatcg ttttcaaagg aaagccagta gctgtttaac tctttcccct tcttttcaat 3715201 ctctttttgg tctccttttt ccactgagtc attcagctta gaaatgatgg tttccatttt 3715261 atttacggat gcggtgattt ctttagtgac cccgcttttt tcagatgaag ctttttcttt 3715321 ggttgaagat gtgtcattgg ctccgcagcc tgcgcacagc gcaaggatgc atccggctga 3715381 tacagcgatt tttgtgaaat tcattttgtc agttcctttc cgtttgtaaa atgttttgcc 3715441 gcttctgaaa caagcgcaat cagtaaaaag agtaaaatca acatttgcgg aatcgtgctg 3715501 tacacagacg gataaattcc tagcaccgat acagacggca gccagctttc tgcatcagac 3715561 ggaagaatgc ccgccagttg aaggctgtga acgccggttc cgagaaattt cacgcacata 3715621 tacaggacaa ccgccattga tagaagaaaa aacggcttca atggaatgcg cattccgagc 3715681 ttgatcatca gaacaccgac gatgacgaga acgataagcc ctgcggcagt tccgccgatc 3715741 agttcagtga gcgggagctt cccgacaagc ccgatgaaaa agatgaccgt ttcgagacct 3715801 tctcttacaa ctgccagaaa tgcaatgagc gcaaaggaaa gcaggcttcg tttttttagt 3715861 gcctgtgact tctggatatt gattttttct ctccatttat ccattgaggc gtttctgtgc 3715921 agccacaccc cgacatacaa aagcatgaca gcggacagta cgccggtaac gccgccaagc 3715981 aagaaattgt tttctccgaa tacactggag gagaacagaa ccgtgacacc gatgccggct 3716041 gctaaggaaa cagccatgcc ggcggacgcc ccgccccaga tccatgtcga ggaacgcgta 3716101 acccgcgctt tttttgtcat ggttaatagc gctccgatga caaggagggc ctccattcct 3716161 tcacgaaccg ggatcagcgc cgcatcccac cagctgtagc tgcttgaagc gatcggctcg 3716221 agcaattgaa tcatttcgtc aatttgcttt gatacctttt caggatggct gccgatctcc 3716281 gccttcatca gcgccagatt ttcctccgat gtcgtatagg cttctttcga ttgggacacg 3716341 acatctccct caacagcgag ccaggatgta actaaattgt cgattgcgga tgacgcttca 3716401 tccaattgtt ttttttctat gaactgtttt gtgtctttca agctttgtat ataggctgtt 3716461 aaggacgccc ttgattgacc tgaggatgtc tttttcagca cgacagcctg ctgataggtt 3716521 tctaaatgag acgcaagctc ttcaagctgt gttttgagct tacgtgcgtc ttgattgata 3716581 aaagaaagag aaatcatcgc gatattcgcg tccatttcac tgtgagaaga aaggttttct 3716641 ttcttaatag aaggttcttc ttttttccac ttcgccttga aggtgtcaaa cgtttgttgt 3716701 gccgaatcca tatccccgtc ttttacggat ttgatcattt gcttgtttaa ttgaattaat 3716761 gcggcgatcg gatcatcttc cgcatgtgcc gcagaaccga aaaccatcaa caagctgaat 3716821 agaataagtg ccagcccccg agccatcatg ttcctcctat aattgaaaat gattatcatt 3716881 gtataacata atcatagcca gttcctgtcc tttgtcaatt aaaatttgaa ggtctgaaaa 3716941 ccttgatgga cagcaaaaaa gctgtccttt tacagaacag ccctttgaag gaaaatgaac 3717001 gattatcttc ctgttttata cgtttgaatt tcctcacgaa acttgcgtgc agcactctca 3717061 ggatcctccg cctgactgat ggcgctgatc atactgacgc catcggcccc cgcttggata 3717121 acaggtgcgg cattatctat tgtgattccg ccgatgccga caattggaat gctgatgcct 3717181 tggcggcgca ctgcttcgat aagagataca ccctgtaccg ctctcgtatc ttttttcgtt 3717241 tcagtcggat agatcggccc aagcccgaca taatccgctc cgtcttcttc ggcttgcttc 3717301 acctcagaca tcgtatgggc agaaacgccg agaatcatat cacctatggc agctcttacc 3717361 tctttcgcat ttgcgtcttc ctggccgatg tggataccat cagctttcag attcagagcc 3717421 aattccacat catcattgac aatgaacgga acaccagctt cacggcaagc tgcctgcgct 3717481 ttttcagcaa atttaatccg agcctctcct gtcagcgcat ccccgccttt ttcacggaac 3717541 tggtacaggg tggcaccgcc ttttaacgct ttttgtacaa ctgtaacagg atcggctttc 3717601 gtattgtttg accccataat gaagtataca gataataact ctttcatcat ttcccgagaa 3717661 atacgagtca tgagacagtc accctttcta tagtcgccca ttcttggacg tcttgttcag 3717721 taacagttga aagcttgttc agcaattcaa tctgaaagct tccagggcct ttgtcagccg 3717781 tctgctgtgc ggcaagctga gcggcgaccc catacgaaga aatggccgca atagcagcaa 3717841 acaatggatt ttcttccaca gcgcaaaacg caccgacgac ggaagtcagc aggcaaccgg 3717901 cgcctgtcac ttttgtcagc agcttgtggc cgttatgaag ggtgtataca tgtgacgtgt 3717961 cggctatgac atcaacttca ccagttatcg caatgaccgt gtttagcttt tgtgccgcct 3718021 gctgagccag ccggatgatg tcgcctccac cttcacccgc atcaacacct ttgatcagcc 3718081 aatcggtcac gccgacggta tgggcaattt ccgccgcatt tcctctgatt gcagcaaggc 3718141 gcacctcacg aatgatgtca cgtgccgatt cagtgcggaa cggtgttgct ccggcaccga 3718201 caggatcaag aatgacggga acgccatgtt cattagctga ttttcccgcg atgatcatcg 3718261 cttcgactga ctccttgctc agtgttccga tatttaaaac gagtgcaccc gcaattttcg 3718321 ccatatcggc gacctcttct tttgcgtacg ccataacggg cgatgcgccg agcgcgagca 3718381 ggccgtttgc tgtgaaattc gttacgacat tgttggttat gctatgcacc agtgggctat 3718441 gccggcggac agccgtaaga cattttgctg ctgattgtgc atccatattt gcatcatcct 3718501 ttactatctt ttttcgggtc ccataaatac gatttcgtat gttcgagcca agctctggcg 3718561 gcaaacgaca agtacctgtc ctttctccaa ataatggcga ggtgccaagg gatgaccgga 3718621 tcgacaagcg gaatgacttt cactttttcc gggtcaaggc cgcggcagat ccgttccggc 3718681 aaaagcccga tcccaaggtt ggcggatacc atctcactaa taaaatccca ttgtgatgtt 3718741 tcataaatga tatggggccg gaacccagcc ttgatacatt ccgtcataat tcggttgtgc 3718801 aggacaaaat cctctctgaa gaaaataaaa ggctcgtcct tcaactcacg cagctgacat 3718861 tctttctcat cagccagccg gtgggaaggg tgaacgacaa gcattaaggt ttcttttacg 3718921 attgtaaacg aatgaaagat atcttcgttt gcgggaagga ccacaacgcc gatatcaaga 3718981 gagccgtccc cgacaccttc ttggactttt atagaaccgt cttcgactag ctgaaaggtg 3719041 acattcggat agttttcacg gaaatcgccg agcactctgg ggaaaaaccc cgatccgatc 3719101 atcggcggca gtccaatccg tacgtgccct ttcttgactt ccataatatc atttaattct 3719161 gacgtcaggt tttgaaatga tttaatgatt tcctgcgcct gcacatacat gctatgaccg 3719221 gcatcagtca gttccacctg cctgccgttt cggtaaaaca gttcaattcc gagctcttct 3719281 tctaaatttt tgatcatttt tgatatcgtc ggctgagaaa cataaaggga ttgggaagcc 3719341 ttcgtaaaac tttttaaacg ggcgacttcc aagaaatatg ttaaatggcg gatatccatg 3719401 cgcttcaccc tttctataga caaaaggaat acttcttatt cttaatatat attttaccta 3719461 tagagagacc ttatgtacaa taagtatata agggaggcat caatatgaaa aaactgttgc 3719521 taaccgttat tcaaatcgct ctgttattta tatttgctcg gctgattaat tgggtgacag 3719581 cccttcttca tataaatatt cccggcagta taatagggat tgtgattctt ttcacattat 3719641 tgcactttaa cattatcaag cttgaatgga tcgagcttgg tgcagcgtgg cttctcgggg 3719701 agctgctttt attttttatc ccgtctgccg tcggagtgat tgaatacgga gacattatgt 3719761 cgaaatttgg tgtcagcatt ctgcttgttg tcatcatcag cacgtttgtc gtgatggtgt 3719821 ctacaggaac gcttacacaa ctcatcgcaa agagaaagga gaaaaagcat acgtgttcat 3719881 cggaattgta agtttgtttt taacggtttt ggtgtattta ggagcaaaaa aggtatatca 3719941 acgctttccg cgtgtttata cgtcgccgct attggtgacg cccgctgtat tagtcggtct 3720001 gctgctgctg gtgaatgtcc cgtacgagtc ctataatctc ggcggcggat tgctgaccga 3720061 tatgctacag ccggccaccg tggcattcgc gatcccgtta tataaatatt tccctgtttt 3720121 aaagaaatac gcagtggaaa ttattttgaa tgtggccgtc ggttcatgca tcgcgattat 3720181 ttctaccgct cttattgcga aatggcttca cctcggcacc ggcttaattg acagcctcgt 3720241 cccaagatca gtgacaacgc cgatcgcgat gaacgtatct gaaatgatcg gcggtatgcc 3720301 tgccgtcaca gccgtgtttg tgattttaac cgctttgctc ggcacagtga tcggcccgat 3720361 ggtcatccgt tatttccgca ttgataacga aattgcgcgg ggcgtgctgc ttggcacaag 3720421 cgcgcacgga gcgggaacgt caaaggcatt tgagctcagc tctgtgtccg gcacgatttc 3720481 cagcgtgtcg atgatcttag ctgcgattat gacgctttgc gcggcgccgt ttttgctttc 3720541 atttatgtaa aaaactgtcc tctcgagggc agtttttttt atgtgcttcc ccttattgaa 3720601 aagctggcga attccaatat aatgtatttg tggataccaa aggaggcacc ctgatgcaca 3720661 acttgcaggt gaggcggcat tatgccgcgt taaaaggatt ttatttgttt gcttttctcg 3720721 gtacgggcag cataattccc ttactcagta tgtatttaac gaaggaacag catttaagcg 3720781 gatcacaggt cggcttgatc atgtcactgg gcccgattgt gatgattttc tttcagccgt 3720841 tttggggcat gctgagcgac tatacgcaaa aaacgaaagg cctgctggcg gtttgcacat 3720901 caatcacagg catcattgga ttagcctata ttgcatttga cagtttccct ctgtttattt 3720961 tgattgcggc ctgttttgca gcctttcaaa gcacgattat tccactttcg gacagcattt 3721021 cactaaggta cacacaagaa acaaacggca actacggcgg aatccgcctg tttggttctc 3721081 tcggcttcgg tgtcgcggtg tttgccatgg gacaggtgac gaaccagctg taccccattc 3721141 acgtgatctt tatctttggc tgtgcctttc tgtgcattgc tgccatattg gcttcacaag 3721201 tgcccggcca gcagaaaaca acaaaggtca atatccgcaa aggattccgg gagcttatca 3721261 gcaacaaaac tttcctcatc tttatgatca tcacctttac gacatttgct ccaaacttag 3721321 cgaacaatac gtatttcagt ctttttctgg acaaaagcgg cgcgtcactt tccgctatcg 3721381 gcattttatt tttcatcggt gtcatttcag aaattccatt tatgagattc gcccaaacat 3721441 ttatagataa aatggggctg ctcaacgtca ttatgctgtc aggcggagtc tcattattca 3721501 ggtgggcgct ctatttcacg gcgccttcac tatggatcat ttatgcgacg gtctttcttc 3721561 agggagtggc catcggttta tttatcccgg cggcgcttca atatgtgaaa aagattaccc 3721621 caagacacgt tgaagcgacg gcgctgacca tgtacgccgc cattggcaac gggttcggca 3721681 actggttctg cacatttgca ggcgggtaca tttttgacta cgtgtcgatc ttcgcagtct 3721741 acttgctttt tggcattctg agcatagcag gctttggcct gacattatat ttaatgaagg 3721801 ctgaaaaaaa caaacataca cttcatcagc cggctgttac ttttaaacca taatgactat 3721861 aatgaacaaa agaaaggatg tgcgttatga acgggcaaga gcgaaacagc atttcgaaag 3721921 ggttgcaggt tgatattgta ttgaaagcag atcaaaaaac aggaaaactg acgagaggga 3721981 cagtgaagga tattttgacg aaatcaaact ttcatccgca tggcattaaa gtccgtcttg 3722041 aagatggccg catcggccgc gaccagcaga tcgtttctac ataaaaaaaa gctgcccctg 3722101 aacagggcag ctttttcatt tattttttct gcagaaggac cactttcagg tagttgcctt 3722161 ccggaaatgc cgaaatcgtt ttgaaatcct ccggcagcgt aaattcctca atgatcgtgt 3722221 agcgttcatt tgtttcttta aaggcggcat caataaagcc tttgaacttc ttcatgccaa 3722281 aggcgctgct gtttgtagag gcaacaatga cacccttgtc agcagtgatg gcgatcgttt 3722341 ccttcagcag gtttttataa tccttggccg cgctgaaggt gcgttttttt gtgcgcgcaa 3722401 aggaaggcgg atctagaata atcagatcaa agcgcaaatc cttttttgca gcatatgaaa 3722461 aatagttaaa aacgtccatc actttaatgt cgtgcgcttc gtaatccagc ttgttcacgc 3722521 tgaattgctc gatcgttttg gcaagacttc gatttgccac gtcgacgctt gttgttttct 3722581 ccgctccgcc aagcgccgcc gccacggaga atgcacccgt ataagaaaac gtatttaaaa 3722641 cggttttccc ttttgcatag cggtctctga tcgccttgcg cacatgtctc tgatccaaaa 3722701 agatgcccgt catggcgcct tcattcagat ccaccgcgta ttgaatgcca ttctcttgga 3722761 tgatgatcgg gaactcgccc cttctccctt tcacgaagtc atcatcttca acgtattgtc 3722821 cagccgtgtc gaagcgtttc ttctcgtaaa tcgctttata atcaagatcc atctcatcca 3722881 atgcggaaat cagcatgtct ttaaaggtgt aaattccctt gctgtaccat tgaatcagca 3722941 ggtagccgtc ataatagtcg atggtgacgc cgccgacacc gtcaccctca ccgttgaaca 3723001 ggcggaaagc tgttgtatct tgagcctcaa atagtttggc gcgcgcttgg gccgcttttg 3723061 ttaatttgct gagaaaaaat gcttggtcaa tctgttcatg tttattgcgg gtaagcgtcc 3723121 agccaacccc tttgttttgc aggccgtaat agccccgcgc gagaaactcg ccgccgctct 3723181 cagacacgat atcaacgagg tctccttctt tcatgtgccc cgcactccct gcgagagctt 3723241 ctttttcaat aaggggatag ccttttttta ttttggcagc gtgtgctttt tttagggtga 3723301 gtagcttcat atatgtcgtc ctctttccgt ttgctttctc ttatggtacc acaaaacgcc 3723361 aagatgtctg cattgacaga aaggaaaggt ttttctacga tagacaaaaa gagttacgag 3723421 gaggagcagc atggcaaaac gaattgacca tacaggcatc atggtaagag atattaacgc 3723481 gtccatcaca ttttatgaag aggtactagg catgaaattg aaggatcgca tcactcacac 3723541 gaacggtgta atcgagcttg cttttcttgg ctttgaagac ggcccggaaa cagaaattga 3723601 actgattcaa ggctacagca gcgagcttcc cgctgaagga aaagtgcacc acattgccct 3723661 gctgacggat gacatcgcgg ctgaatatac aaaagcggaa aaaatgaacg caaaatttat 3723721 cgacgaggag atcacaacac ttccaaacgg ataccgttat ttctatatcg aaggccctga 3723781 cggtgagtgg attgagttct ttcagcggta aaaataaaga acgtacattt tgtgatgtac 3723841 gttctttttt atctatacca actgatatac gttgactcat cgcaaatcat agcttcccag 3723901 cccatacgct caaccaattc atggatgttt ttatctttgg ctaaaaagac attaatgaat 3723961 gagtcatata cactcataaa cacaaaatcc attttctcat cagttaaaac gagctctgtt 3724021 gcggcttcat caagaaccgt ccgcaagttg gcttcagtta tgtccaaaac gccgcggttt 3724081 tccacaatcg gttctgcgta ataaaaccga ttggatccgt tcgcacctaa tacctttacc 3724141 aaactcggaa tatgaaaatt tgaaatatga tcctcactgg gataatagag gtctccattt 3724201 atgttttcat gtaacacctc agccaaatcc tctctcgcga actcgtccct taaagcgcct 3724261 atcgacgtca ttaaagccag cgccagctca gcatgtgttt gaaagccgca agaagacata 3724321 accttcttcc aggaaacagc cttgcctatt cctcttattt cattatcgtt tggataaata 3724381 tgttcataat cattttttct ttttgcattc tcccatcctt caggcatttg gataaaagga 3724441 gaaaagataa gagcagcaga tgagtattca actggtactt gttgtaagat tggtgattcg 3724501 tcatctaacc atatataatc tagcatgcgc acctccttta catattctaa cattcctttc 3724561 gtttgaaaga gatgatcagc cctatgacag gctgatcatc tatcacatca catttttatc 3724621 cccagattca accgcactct cttcccgcca tttttgatga tcccatattc tgaaaaacgg 3724681 atagtagata gcacaggtga tcagcagatt taccagctgc ataactgcgc ccgacacctt 3724741 tccgcctgtc gccaggtaac ctgatatgag cggcggcatc gtccatggca ccgcgattcc 3724801 ggccggtctt gccaccagcc cggtgctcat gccgatataa gtcgcggtaa tcgtgaggag 3724861 cggtgcgatg ataaatggga caataaggag gggattcatg acaatcggca tgccgaaaat 3724921 gatcggctcg ttgatattaa atagcgcagg gccgattcct aatcgtccaa gctgcttcat 3724981 ttgtttgctg cgggagcgca caagcatcgt caggacaagc gccagcgtcg ccccgcttcc 3725041 gccgacattg atccaaattt gaaaaaactg agtcgtaaaa atactcggca gcgcctcgcc 3725101 tgcttggaag gcgagacggt tggcatccat cgcgccgtac caaatcggcg ccatgattcc 3725161 gccaatgatg gaagccccgt gaatcccgca cgaccaaagc agcatctgca caaattcagc 3725221 gatcaggctt ccgccgagac tgccgccaag gatggaaagc ggtgtgccaa gcaggtctcc 3725281 tacgacattg tgcagactct gaaaaggtgt catttcaatc agaagacgcg ccagccatac 3725341 gagaagcaca atgataaagc cgggaatcag cgcgacaaat gatttgctta ccgcaggcgg 3725401 cacaccgtct ggcattttga agacgatatt tttttgaata atgtaccgat agatttcggt 3725461 tgaaaacaag gcgatcagca tggcgacaaa taagcccttg ctgccgagca gcgtgatcgg 3725521 gattccgccc cctaccatga tggactccgt tgagccatgc ggtgtaaacg gcacctcaaa 3725581 cggtgttgcc agcagaaatg cggcaattga aatcgctccg gcagaaaggg catcgacacc 3725641 atagctttct gccagccgat aggcgatccc aaaagcggca atcatcgcca taatatcaaa 3725701 cgaagcgtta acaggatatc cgagcttatc ggcccactcg ttcccaaaca cactcgccat 3725761 gaaatcagca taccccggaa tcggcaagct cgttaaaatc aagaagacag acccgataat 3725821 aatcagcggc atggtcagga taattccgtc acgcaaagcg ctgagatgcc gctgcccggc 3725881 aattttcccg gcgacaggca ttattttttc ctccatcacc cgagtgaatg tgctcatctt 3725941 aaaaaccccc ttttctcatt gctttgtgaa caacctccgc aatgttttct ttatcttatt 3726001 ttgaaaacgc ttacaaattc atttggaaaa tttcctcttc atgcggaaaa aatctgcatt 3726061 ttgctaaaca accctgccca tgaaaaattt tttccttctt actattaatc tctctttttt 3726121 tctccgatat atatatcaaa catcatagaa aaaggagatg aatcatgaaa aacatgtctt 3726181 gcaaacttgt tgtatcagtc actctgtttt tcagttttct caccataggc cctctcgctc 3726241 atgcgcaaaa cagcagcgag aaagaggtta ttgtggttta taaaaacaag gccggaaagg 3726301 aaaccatcct ggacagtgat gctgatgttg aacagcagta taagcatctt cccgcggtag 3726361 cggtcacagc agaccaggag acagtaaaag aattaaagca ggatcctgat attttgtatg 3726421 tagaaaacaa cgtatcattt accgcagcag acagcacgga tttcaaagtg ctgtcagacg 3726481 gcactgacac ctctgacaac tttgagcaat ggaaccttga gcccattcag gtgaaacagg 3726541 cttggaaggc aggactgaca ggaaaaaata tcaaaattgc cgtcattgac agcgggatct 3726601 ccccccacga tgacctgtcg attgccggcg ggtattcagc tgtcagttat acctcttctt 3726661 acaaagatga taacggccac ggaacacatg tcgcagggat tatcggagcc aagcataacg 3726721 gctacggaat tgacggcatc gcaccggaag cacaaatata cgcggttaaa gcgcttgatc 3726781 agaacggctc gggggatctt caaagtcttc tccaaggaat tgactggtcg atcgcaaaca 3726841 ggatggacat cgtcaatatg agccttggca cgacgtcaga cagcaaaatc cttcatgacg 3726901 ccgtgaacaa agcatatgaa caaggtgttc tgcttgttgc cgcaagcggt aacgacggaa 3726961 acggcaagcc agtgaattat ccggcggcat acagcagtgt cgttgcggtt tcagcaacaa 3727021 acgaaaagaa tcagcttgcc tccttttcaa caactggaga tgaagttgaa ttttcagcac 3727081 cggggacaaa catcacaagc acttacttaa accagtatta tgcaacggga agcggaacat 3727141 cccaagcgac accgcacgcc gctgccatgt ttgccttgtt aaaacagcgt gatcctgccg 3727201 agacaaacgt ccagcttcgc gaggaaatgc ggaaaaacat cgttgatctt ggtaccgcag 3727261 gccgcgatca gcaatttggc tacggcttaa tccagtataa agcacaggca acagattcag 3727321 cgtacgcggc agcagagcaa gcggtgaaaa aagcggaaca aacaaaagca caaatcgata 3727381 tcaacaaagc gcgagaactc atcagccagc tgccgaactc cgacgccaaa actgccctgc 3727441 acaaaagact ggataaagta cagtcataca gaaatgtaaa agatgcgaaa gacaaagtcg 3727501 caaaggcaga aaaatataaa acacagcaaa ccgttgacac agcacaaact gccatcaaca 3727561 agctgccaaa cggaacagac aaaaagaacc ttcaaaaacg cttagaccaa gtaaaacgat 3727621 acatcgcgtc aaagcaagcg aaagacaaag ttgcgaaagc ggaaaaaagc aaaaagaaaa 3727681 cagatgtgga cagcgcacaa tcagcaattg gcaagctgcc tgcaagttca gaaaaaacgt 3727741 ccctgcagaa acgccttaac aaagtgaaga gcaccaattt gaagacggca cagcaatccg 3727801 tatctgcggc tgaaaagaaa tcaactgatg caaatgcggc aaaagcacaa tcagccgtca 3727861 atcagcttca agcaggcaag gacaaaacgg cattgcaaaa acggttagac aaagtgaaga 3727921 aaaaggtggc ggcggctgaa gcaaaaaaag tggaaactgc aaaggcaaaa gtgaagaaag 3727981 cggaaaaaga caaaacaaag aaatcaaaga catccgctca gtctgcagtg aatcaattaa 3728041 aagcatccaa tgaaaaaaca aagctgcaaa aacggctgaa cgccgtcaaa ccgaaaaagt 3728101 aaccaaaaac ctttaagatt tgcattccaa gtcttaaagg tttttttcat tctaagaaca 3728161 ccacacacaa cctttttccc atccattgta caggcttttc atactattgc tatacagcca 3728221 tgaacagcat aaaatgaacg ttattacagt tatcaccaca tatggcggga ttgtgactgg 3728281 gcaggcaggc aagacccaat gatgcaaagg gagtattaat gcctaaaaaa cagggcattt 3728341 taactcttct tttcgtgttg ggctcataac ggcgccttgg acaaccccct attctcatgc 3728401 tccgtcgtcg acgcgggcat ttttgtcatt ttcagccggt atttctcact tttttcattt 3728461 tgattgtcaa cttttcattt gatacgatga acaagccgac ttttcttcag caaaggaggt 3728521 tttaattgct tgcataaaga gattgcaaaa gaattactgc tgctcgcagg aggaaaaaac 3728581 aatattatca gcatcagcca ttgtacgacc cgtcttcgtt ttgatgtaaa ggacgagacg 3728641 aaaattgata tacatgccat tgagaacctg caaggtgtgc agggcacctt tttccgctat 3728701 gggcttttcc agattatctt cggagcaggc gtcgtcaaca aaatatataa agaagtcgtt 3728761 catgtatggg agaccgcgcc ttctgaagag cctgtccacc agaaaaaagc cagccggaag 3728821 ctgaaccctg ccgcagcttt tgcgaaaaca ctgtccgata tttttgtgcc gattattccg 3728881 gcaataacag caagcggcct gctcatgggg ctgatcggca tgattaaggt gtttcattgg 3728941 ttcgctgccg gcagcccatg gattaaaatg ctcgacctcg tgtccagcac agcctttatt 3729001 ttactgccga ttttagtcgg cttcagtgct gcacggcaat ttggcagcaa cccataccta 3729061 ggggcagtga ttgcagggct tttgacgcat cctgatctgc tggacccgtc tatgctcggc 3729121 agcaaaaccc cgtcttcttt agacatatgg gggcttcata tcccaatgat gggctatcag 3729181 ggttccatga taccgattct tctttccgtt tttgtcatga gcaaaattga gaagctatta 3729241 aaatcgattg tgccgaagtc gcttgatgtc gtgatcattc cctttattac ggtcatggtg 3729301 acagggtgcc tcgcgctgat tgtgatgaat cccgccgcgt ccatcatcgg ccagatcatg 3729361 acacaatcga tcgtctatat ttatgatcac gccggcattg ctgccggagc tcttttcggc 3729421 ggcatctact ccaccatcgt cctatctgga ttgcatcata gcttttatgc aattgaggca 3729481 acgctgcttg ctaatccgca tgtcggtgtc aactttttag tgccgatatg gtcgatggcg 3729541 aatgtggccc aaggcggagc ggggcttgcg gtattcctca aaacgaaaca atcaagcctg 3729601 aagaaaattg cgctccccgc ttctctgacc gcgtttttag gcattgttga gccgattgta 3729661 ttcggggtaa atctcaaatt gatccgtccc tttatcggag cagccatcgg cggtgctatt 3729721 ggcggagcat acgtggttgc ggtacaagtt gtggcaaatt cctacggact gacaggcatt 3729781 ccgatgattt caatcgtgct gccgtttggc gccgctaatt ttgttcatta tatgatcggt 3729841 ttcttgatcg cagccgtctc tgcttttata gctacattgt ttctcgggtt taaagaagag 3729901 acagaataac tggatttatt cgatttcatt cataaaacgg gggatgaaag gacaaaaaag 3729961 ctatgaaaat taaaagaatc ttaaatcata atgctatcgt cgtaaaggat caaaatgaag 3730021 agaagattct cttgggtgca ggaattgcgt ttaacaaaaa gaagaatgat attgtcgatc 3730081 cgtcaaaaat agaaaaaacc tttatcagaa aagatacacc tgactataag cagttcgaag 3730141 agattttaga aacattgcct gaagaccaca ttcagatttc tgagcaaatt atctctcatg 3730201 ccgaaaaaga gctgaacatc aaaatcaacg agcgcattca tgtcgctttt tcagaccatc 3730261 tttcttttgc aattgaacgc ctgagcaatg ggatggttat caaaaatccg ctgctgaatg 3730321 aaatcaaagt cctttatcca aaggagttcc agatcggctt atgggccaga gcactgatta 3730381 aagataaact ggggattcac attcctgatg atgaaatcgg caatatcgcc atgcatatcc 3730441 acacagcaag aaacaatgcc ggcgatatga cacaaacgct tgatattaca acaatgatcc 3730501 gtgatattat cgagattatc gaaattcaac tgtctattaa tatcgttgaa gataccatct 3730561 cttatgaaag gctcgtgacc catctccgct ttgccattca gcatatcaaa gcaggcgaat 3730621 ccatttacga gctggacgca gaaatgattg acatcattaa agagaagttt aaggatgcct 3730681 tcctgtgtgc cctaagcatc ggcacctttg tgaagaagga atacggcttt gagtttcctg 3730741 aaaaagaatt gtgctacatc gccatgcata ttcagcggtt ctaccaacgg tcagtcgcac 3730801 gctgagacaa acaaaaaacg cttttgatca tctcaaaagc gtttttttat ctgatttatt 3730861 ggttgatcgc cggattccca atcgtattcc acttcgtata ggacatgtaa tggaaatact 3730921 catcgcgata cggatgtttt gtattggagt tccaaggctt ttctccgccg cagaagtgca 3730981 cgattgccgg gttttctctt gtttcattat attgcttccg ccctaacaga gtcgatgggg 3731041 ttttcagctt taacatgata taggtttgag cgttccagcg cggatgaagt tcataccact 3731101 gatcatacaa gatcgcattc agtgcatctt ggtcatgcag cacaagaaag tcttcgtctg 3731161 ggtgttcatt gataaagttg atgacttttt ctgtgatgtt ttgctttctc caagactcaa 3731221 aatcaataat catgatacct gagttaaaat acttccctgt atcagtgacg ttcatttctt 3731281 tcaggcgttc atgctgcccc gcatcctcaa cagcggctac ggtgtatggc gcaatgtcta 3731341 agtcccatag cttagaaata tcctctagga caagcgcatc acaatcgatg taaatcattc 3731401 gtttgatgct ttcatcctta attaagtcgg gaatcgaaat gcggtaatac gcggcttttg 3731461 taatatggct gctctcaacc gcatgttcat acatgttggt atccacttct aaaaactcaa 3731521 tcggcactcc gaatttcaaa gtggtttctt ccagtctttt tttgttatca ggcttaattc 3731581 cgccatcaat gacgtataat tttacctctc tctcctgatc catgttagtc aataaagaaa 3731641 cgaacatccc acctaaatga cgagcataat tatcatctgc gcatgatacg atatgcatga 3731701 tttcatcttt cctcaatggt attcatctcc ctttttgttg tacaagttac ataccctttt 3731761 tcaaaaaaat aaacacgttc tccgacattt ttttaaacag aatgtgtgat acaacaaaaa 3731821 aggtgtcatt ttttgaagat gcgataaagc caataaagaa tgaaaaagct tgcgattgtg 3731881 atggcttcag ccgagacgat ataccacggc catggcccga gaacatctaa gagagaggaa 3731941 ccgcccggtt ttttcgtcaa atacatataa ttcgcgccaa gccagcgatc aatcagaaaa 3732001 atacagacgc cgtacacatt aacaagcagg actgtcaccc ataacgagcg ctggcccatt 3732061 ctgtaggtgc caatcacagc catcagcaga caggataaaa acacagaccc gtgagaaata 3732121 aaaaagagga tatatcggat atgcggaaat gaaaacatac cgaggtcagg agtggcaaga 3732181 gcctgaatcg aactgccgat gccgacaaaa aacaaaaaca caaacagctt tctgcttttt 3732241 gtcactaaca taatagctga caaatacacc gacaggtcac taagctggag aggcaatgaa 3732301 gtgcgcaccg accacctgtc cgtggcgacc atccatattt gatagccgat ttgcgaacca 3732361 agcaaaagaa acacaaacag agaacgcaaa aaccggctgg ccctcggctg cttgacctca 3732421 tcttggaaca aaaacaacag aatggccaaa agggagataa tcgctaacgt cactacatgc 3732481 tctgtcgaaa acagatgaaa cggatcatgc ttatagtcgg attgaacata tttttgcaaa 3732541 actgcacccc cgttttcggg tttttgttta ttttggcgtt gtttgggctt tttttattca 3732601 accgatatat gggcttgaag ttcacaccag actctgttaa aattcgtttc atagctaatg 3732661 attctgataa tttaaggcag gcctaaaaaa tggaacgttc acatcaacat cagcagcttc 3732721 ggaaggaaga acacgataca ctttctaagc tcaaacaaat gcccgtcgag tcactcaacc 3732781 tggaagccat ttcgatcgct acgaatctgt atcggtctgc acaaaggctc cgtgtcaaaa 3732841 tggagactga ggttctttct acctataacc tttcttggac cgctttctcc attctttatg 3732901 atctatgggt atggggagcg ctcgaaacga gaaaaatcgc tgagctgtca gggatatcta 3732961 cagctacagc aagcaacgtg atcaaaacgc tcgaaaaaaa gagtttttgc cgtaaaagca 3733021 tcgacacaag agatcggcga ctcgtgtttg tctcaatcac cgattccggc aaacaagcga 3733081 tcgaagaact ctacccggag tttcacaaag gggaaacaga gctcattgcg ggaatgacga 3733141 aggacgaaca gaaaatattg acagggctgc ttagaaaggt agctgacaat cttcatacaa 3733201 cataagcttt gacgggaatc cagtagcggt ttgtctccct gtttcagaga gccggcggta 3733261 ggtgcgagcc ggcgcacagg caaacgtgaa ttacctcccc aagctttctt tgtgaacctt 3733321 agtagcaaag aacgggaaac cgttattcga atgagcggaa gacaatgtct tcaaccaggg 3733381 tggtaccgcg tgcattgagc cacgtccctt attgggatgg gctctttttt gtgtttgtaa 3733441 aaaaggagga aaaatgatga gaacatttga gcagctcaca gcgtcacaac aaaaagaggt 3733501 agaaagacag cttcagctat acatgacagg cgcccacgaa gtcataccgc cggaggaatt 3733561 aaaggcaaag ctcgtgaaat caatttccac gggcacgccg cttaaaatta agctcggatt 3733621 agatccgtct gcaccggatg tacatttggg ccatacggtt gtgttaaata agcttcgcca 3733681 atttcaagaa aacggccaca ttgtccagct gttaattggg gatttcacag gaaaaattgg 3733741 tgatccgacc ggaaaatcgg cagccagaaa gcaactgact gatgaagaag ttcagcacaa 3733801 tgccaaaacc tactttgagc aattcggaaa agtgcttgat ccagaaaaag tcgagcttca 3733861 ctataactca aaatggctga aaacattgaa tctagaagat gtcattgaat tagcagggaa 3733921 aataacggta gcccgcctga tggagcgcga cgactttgaa gaacgcatcg ccatgcaaaa 3733981 accaatctca ctgcatgaat tcttttaccc attgatgcag ggctatgatt ctgtcgttct 3734041 cgaaagtgat attgaattag gcggaacgga tcagcatttc aatgtcctca tgggacggca 3734101 tttccaagaa cgatacaaca aagaaaaaca agtcgtcatc cttatgccgc tcttggaagg 3734161 cttggatggc gtcgagaaaa tgtcgaagtc gaaacacaac tacattggca ttaacgaaca 3734221 tccaaacgac atgtacggaa aaacgatgtc actgcccgac agcctgatga aaaagtacat 3734281 ccacttggcg acagacttag agcttgaaga gaaaaaacag ctcgtaaaag acttagaaac 3734341 cggcgccgtt catccgcgtg atgccaaaat gcttttagcc agaacaatcg tccgaatgta 3734401 tcacggagag aaagcagcag aagctgccga acactcgttt aaaacagtct ttcaggaaaa 3734461 cagcctgccg gaagatatac cggccgtaaa ctggaaaggc gaaaaaacga tagcgatgat 3734521 tgatctgctc gtcaagctaa agctcctctc ttcgaagagc gaggcgcgcc gcatgattca 3734581 aaacggaggt gtacgcatcg acggagagaa agtaacagat gttcacgcca aagcagagat 3734641 aagagagaat atgatcatcc aagtcggcaa acgcaagttt ttaaagctcc aataatctga 3734701 tattccgaaa cgcttatgac ccttcattca taagcgtttt tttgcaggta taaagcactg 3734761 tcttttcaaa aacgctctcc atcttgcagg aaactccttt agcatcccga aatattcccc 3734821 aaccatacat ttaggggagg tttatttttg atgaaaaagc ttttgactgt catgacgatg 3734881 gctgttttaa ctgccggcac actgctcttg ccggcacaga gtgtcacccc tgccgcgcac 3734941 gctgtacaaa tatcaaatag cgagcgcgag cttccattca aagcaaaaca tgcgtactct 3735001 accatttctc agctaagtga agcaatcggc cccagaatag ccggaactgc agctgaaaaa 3735061 aagagtgccc tattgatcgc ctcatcaatg agaaaattaa agcttgatgt gaaggttcaa 3735121 cgattcaaca ttcctgaccg gcttgagggt acactgtctt cagcaggacg cgatattctt 3735181 ctccaagcgg cgtcgggctc agctccgact gaggaacaag ggctgacggc cccgctttac 3735241 aatgcgggat tgggctatca aaaggacttt accgctgacg ccaagggcaa aatcgccttg 3735301 atttccagag gagacctgac ttattacgag aaagccaaaa atgccgaagc cgccggagcg 3735361 aaagctgtca tcatttataa caacaaagaa agcctcgtgc ctatgacgcc aaacctgtcg 3735421 ggaaataaag tcggcattcc ggtcgtcggc attaagaaag aagacggcga agcacttacc 3735481 cagcaaaaag aagccacctt aaaactaaaa gcattcacaa accaaacctc ccagaatatc 3735541 atcggaatca aaaaaccaaa gaacatcaaa catccagaca ttgtgtacgt gaccgcccat 3735601 tacgacagtg ttcctttttc gcccggagca aatgacaacg gctcaggtac ctctgttatg 3735661 ctggagatgg cgcgtgtctt aaaaagcgtt ccatctgata aagaaatccg ctttatcgct 3735721 ttcggcgccg aagagctcgg cctgctcggc tcctctcact atgtagatca tctatcggaa 3735781 aaagagctga aacgaagcga agtgaacttc aacttagata tggtaggcac aagctgggaa 3735841 aaagcgtctg agctgtatgt caacacattg gatggccaat ctaactatgt ttgggaatcc 3735901 agccgtacgg ctgctgaaaa aattgggttt gacagcctgt ctctgacaca gggaggatca 3735961 tctgatcatg tgccattcca cgaagccggc attgattccg ctaactttat ttggggagac 3736021 ccggaaacag aagaagttga gccgtggtat catacccctg aagactcgat cgaacatatc 3736081 agcaaagaac gcctccagca agcaggcgat cttgtgacag ccgctgtcta tgaggctgtg 3736141 aaaaaagaga agaaaccgaa aaccattaag aaacaaatga aggcgaaagc atctgacatt 3736201 tttgaagata tcaaataaaa aaagacggca cttgggtgcc gtctttttta atccacttct 3736261 ttcttaatcc ccagcatttt ctcatctagg taatgggcaa tctccgcggc ttctttcagc 3736321 tcatctgtta attgcttagg aacgtcattg ttcaatttat aataaatttt atgttcaagg 3736381 ctcgcccaga aatccatcgc gattgtccgg atttgaattt ctgctttgac gtattccaca 3736441 cggttcgtta aattcacagg catctcaatg attaaatgca ggcttcgata gccattcggt 3736501 ttgggtgtct ggatataatc ctttaccttt acgattctca aatcttcatg ctgcttcaac 3736561 acattcacga cattataaat gtcagaaata aaggaacaga tgatgcgcac gccggcaatg 3736621 tcgtgaatat gctccttcat ttccttcgtc gtaatctcac agccctttct cattaactta 3736681 ttcacgatgc tttcaaagct ttttacacgg gattttgtat gttcaatcgg gttgtgtccg 3736741 tgaatgaggt tatattcctg gctgataatt gagaactttg tatcgagcgc atctagcgca 3736801 aatttataaa ctaataactc atttttccaa tcttccatta ctgtttttaa atcgtccata 3736861 tgtgttacag ataaatccat gttcgtcatc tcctttaacg gaactttatc cgctgtccat 3736921 gtactagacg tccctgtctg ctgcaaggtt ctatgaattt ttttacaaaa tgcggtcgat 3736981 tgtaacaaaa aaagaccgca tgaaacgagc ggtctttttt attatcggaa atagctgatc 3737041 aataatccga tcgagagcag gaatccgaaa aatgtatttg tttgggctgt tgatttcatt 3737101 gcgacaatca tattcatcgg catttcgttc tggacgaagc ccttcactgc ctgaaccggc 3737161 ttaggcacgc tcaaaaagac gacaaacagc catgggcttg cggcaccggt aataaccaag 3737221 ccgacaaccc agatataagc gacggcaaac gacgcagcta acagagtaac agctccctta 3737281 tgccccatca aaatcgccaa tgttttgcgt ccgccttttt tgtcctcttc aatatcacga 3737341 atgttgttcg acaggttaat cgcgccgaca agaatcgcaa tcgggatgga aatcaaaatg 3737401 ctctgcatat tgatcttatc tgtctgaatg aaaaacgaaa tcagcacaaa caccgaaccc 3737461 atgcaaatgc ctgagaataa ttcaccgaac ggcgtgtacg caatcggcag cggcccgcct 3737521 gtatacaggt agccgatcgc catgccgaca aggccgatca gcgcaagcca ccagctgctg 3737581 ctggcacaaa tatagacacc gagcaaaatg gcaatcccgt atgaggcaag agctaattgc 3737641 aaaatcgttt taggcttcat tccgtggcgt acaatggccc ctccgattcc gactgattct 3737701 gctgtatcta atccgcgttt aaaatcatag tattcattaa ataagttcgt cgcgatctgg 3737761 atccataggc aagaaaacag catagccaaa aacagcagca gatcaacctt cacataaaac 3737821 atcgccaaaa cggttccgag cagcacaggc acaaacgatg cggttaacgt atgaggacgg 3737881 gttaactgcc aaaggatctg ccccatgctt tctttttgcg gcgctgtctg accctcaccc 3737941 ttatttgttt ggttcatctt cctcttcctt tctattaaaa ggcttacttt ttttcagccg 3738001 gcagcttaat aaaaaactcc ttttgcttcc ttatctatca taatgacttc tcccttattt 3738061 cacaagatac cgcaagaagg cgttttcttt cttattatac gcttctcgcc ctgatttcat 3738121 taggtttctg ctttcacttg aacgaacagg tacagaaaaa tttttttaag tacattacac 3738181 tttttaaaag ttaaaaagat cttttgactc caggtatctt ttcctttatt atgaatcagc 3738241 tcgaaacatt ccattcttgc ccttgcaggt ataaagattc attttcaaaa acatacgccg 3738301 atatattaat ttgagggaga ttagggaaaa aatgaaactt tttgagcatc tgatcgtcaa 3738361 ataatcatgt gattgtcgaa aaaacgggaa gggaattttt gatatgctgc aattaatgaa 3738421 acagctgtat gaaaaacccg ctgtcaagtg gacatgtcat acaggctttt atttgatgat 3738481 actgcttgtt ttgtttttta tgtatggttt tcacaccgcg aataccggtt catatattta 3738541 taacgatttc taattggaga gagaataact atgaaacttt tacatgctat tcaaacacat 3738601 gcggaaactt atccgcaaac cgatgccttc cgctctcaag gccagtcgct cacgtatcag 3738661 gaattatggg agcagtctga ccgcgcggct gccgcgatcc aaaaacgcat ttctggggaa 3738721 aagaaatctc ctatccttgt gtacggccac atggagccgc acatgatcgt ttccttcttg 3738781 ggaagtgtca aagcgggaca tccttatatt ccggttgacc tgtctattcc gtccgaacgg 3738841 attgcgaaaa ttatcgaaag ctctggagca gaattgctga tccatgcagc aggactctca 3738901 attgatgcag tcggccagca gattcagaca gtttctgcgg aagaactgct ggaaaacgaa 3738961 ggcggctctg tcagccaaga tcaatgggtc aaagaacacg aaacgtttta tatcatttac 3739021 acttccggga gcacaggaaa tccgaaaggc gtgcagattt ccgctgcgaa ccttcaaagc 3739081 ttcacagact ggatttgtgc agactttcca gtcagcggag gaaaaatatt tttaaaccaa 3739141 gcgccgttct catttgattt gtctgtcatg gacctatatc cgtgccttca atcaggcggg 3739201 actttacatt gcgtgacaaa ggatgctgtg aataagccga aagtcttatt tgaagagctg 3739261 aagaagtccg ggctgaatgt gtggacatca acaccttcct ttgtgcaaat gtgcctgatg 3739321 gatccgggtt tttcacagga tctgctgcct catgcggaca catttatgtt ttgcggagag 3739381 gttcttccgg tttctgtggc caaagcgctg cttgagcgtt ttccgaaagc gaagattttt 3739441 aatacgtacg gcccgactga agcgacagtg gctgtcacat cggttgaaat tacgaatgac 3739501 gtcatcagcc gcagcgaatc gcttccagtg ggcttcgcca aaccagatat gaacattttc 3739561 attatggatg aagagggaca gccgcttcct gagggagaaa aaggagaaat cgtcattgca 3739621 gggccgagtg taagccgagg ctaccttggt gagccagagc tgacggaaaa agcgtttttc 3739681 tctcatgaag gccagtgggc ataccgaact ggcgatgccg gctttattca agacggtcag 3739741 attttctgcc aaggacgttt ggattttcag attaaacttc acggctatcg aatggagctg 3739801 gaggaaatcg agttccatgt cagacagtca cagtacgttc gttctgctgt cgtgattcct 3739861 tatcagccaa acggaacagt tgagtatctg atcgctgcta ttgtgcctga ggagcatgag 3739921 ttcgagaagg aattccagct gacaagcgct attaaaaaag agcttgccgc ttctcttccg 3739981 gcatatatga tcccgagaaa atttatctat caggatcaca ttcaaatgac ggctaacggc 3740041 aaaattgacc gaaaacgcat tggcgaagag gttcttgtat gacgccttac agctcgtttt 3740101 tattctttat actgcttggc attcttcttc tgccgacgat cattctcggc ttaaacggaa 3740161 aaagatttca agcatacaac atgttcatat ctatcattat attggcttta attttttcgc 3740221 acgacttaca cggggtcatc gcgctgtgcc tgtttacaat atggcaggtg ctcctgatca 3740281 gcggctatct ggcataccgg cagaaagcga acagcggctt tgtcttttgc ggagctgtta 3740341 tcgcgtctat tctgccttta tttctgtcaa aaatatggcc gtttctttca cacccgcagc 3740401 cgcatcatcc gccgcataac ctgatcagct ttttagggat ttcatattta acctttaaag 3740461 gcgttcagct gattatggaa gcaagagacg gactgctgaa agaacagctg ccattgcacc 3740521 gtctgctgta tttcatcctg tttttcccga cgatttcctc cggcccgatc gacagatacc 3740581 gccggttcgt caaggatgaa cagaaggctt ggacgaaaga agaatacgcc gacctgctgt 3740641 atacgggaat ccataaaatc ttcatcggtt tcctgtataa atttattatc ggctacgcga 3740701 tcaatacgta cttcatcatg aatcttcccg caatcacgca caataagatt cttgggaacc 3740761 tgctgtacat gtacggctac agcatgtatt tattctttga tttcgccggc tacacgatgt 3740821 ttgccgtcgg ggtcagctac attatgggca ttaaatcacc agaaaacttt aataaaccgt 3740881 ttatcagtaa aaatattaaa gatttctgga atcgctggca tatgtctctg tcattttggt 3740941 tcagagatta tgtgtttatg agattcgtat tttggatgac taagaaaaag tggatcaaaa 3741001 accgtatggc cgtctcaaac atcgggtatt tcctgctgtt tatgctgatg ggggtttggc 3741061 acgggctcgc gccgcaatat atcatttacg gcctctatca cgccgttctg atgacgtgtt 3741121 acaacttttt cgagaagtgg aataagaaat ataaatggct gccgtccaac cgctggacaa 3741181 ccattctcgc tattgtgatc acattccatt tcgtttgctt cgggttttat attttctcag 3741241 gaaaaccatt tcatcaccac cattaaagga gattagaaag ctatggattt taaacaagag 3741301 gtattagacg ttttagcaga ggtttgccag gatgacatcg taaaggaaaa tcctgatatt 3741361 gaaatttttg aagaaggttt gcttgattct tttggaacag tagaattgct gcttgcgatt 3741421 gaaaaccgtt ttgatatttt agtgccgatc actgaatttg accgggacgt ttggaataca 3741481 cctaacaaca ttgtaaatca gctgtctgag ttgaaataat gaaaaagcgt tttttcggtc 3741541 caattatttt ggcgtttatt ctattcgcag gcgccatcgc aattccatct tcatggctga 3741601 caggcttcat caccgataag cgtgtgaaag agtcagcaac agccttgaat ccgagtatgt 3741661 ttcaagggct atatttacaa gatcagatgc tcaaagatcc gacatatctt ccgatttacg 3741721 ggtcttctga gctttctcgg ctggacgagt tccacccatc taattatttt caggtaaaca 3741781 atgagggatt cacgccatac cttgtcggca aaggcggatc ccagtcattg attcattctt 3741841 taaacttcgc tgcccacatg gatcagctga agggcaaaaa aatcgtattc atcgtgtctc 3741901 cgcaatggtt tattaagcgc gggtctgatg aacagcattt cgcgccgaac tattctgcgc 3741961 tgcaagggct tgatttggca tttaacgatc agatcgatcc tgaaattaaa aagaaaatga 3742021 tgaaacgcat gcttcgcttt aaggctgtgc aaaacgatgc cattctttct gagctgtaca 3742081 aagcaatggt aaacggtcag acgtggaaag tgaacgcgct gaagccggcg gcgaaagtgt 3742141 attacagcat gctggaaaag aaagatctgt attattcaac gacagaatca tccgggccaa 3742201 agcgctatat ctcgcagtca gtaaaggata agtcatggtc tgaattgaat aaactagcgg 3742261 atcaatcggg caaacgccac tccggttcta acgattttca catcgacaac cctgtctata 3742321 aaaagctgaa gccgaaagtg cctaagctga aagggaaaaa caaaggaaga tcgtatgcgg 3742381 tgtcaccgga atatggcgac tttgaaatga tgctcgatat cctgaaggat gcgggcgcag 3742441 agcctatgtt tgtcaccatt cctgttaacg ggaaatggta cgattacacg ggcttcccga 3742501 aaaaaggacg cactgactat tacaaaaagg taaataaaca aatcagagcg aagggcttcc 3742561 aggttgctga tttctcaggg catgaatatg acccgtattt catgaaagac accattcaca 3742621 tcggctggaa aggctgggtg tatgtcgata aagcaattga cgaattttat aaaaccggaa 3742681 aagtcacttc atcctgagca tctcatagga cgcggctgca tatttcctgc taagatttgt 3742741 aatagtaaag gaatcacagc caacttaatt aagaggtgtt acatccaatg aagatgacaa 3742801 ataatacggt tttaatcaca gggggttctg ctggcatcgg gcttgaactg gccaagcgcc 3742861 tgctggaact tggcaatgaa gttatcattt gcggacgcag cgaagcacgt cttgcagaag 3742921 cgaagcagca gctcccaaac atccatacaa agcaatgtga tgttgcagac cgttcgcagc 3742981 gggaagcatt gtatgaatgg gctttaaagg aatatccgaa cttgaatgtt ctcgtcaaca 3743041 acgccggcat tcaaaaggaa attgacttta aaaaagggac agaggagctt tttgtggacg 3743101 gtgatgaaat tgaacttaat ttccaagcgc ctgtccattt atccgccctt ttcacacctc 3743161 atttgatgaa gcagcccgag gcggcaatcg ttcaggtcac atccgggctt gcgtttaacc 3743221 cgttagctgt ttatccggtg tactgcgcaa caaaagcggc acttcactcg ttctcgctta 3743281 cgctcagaca ccagctccgc gacacgagcg tggaagtgat tgaaatggca ccgcctatgg 3743341 tggacacggg cttaaaccaa aaatcacgcg ataaacaagg cctgacgtac cggggcattt 3743401 catctgaaga atatgttcaa tatttcttgg acggcttgaa ggaaggcaaa caggagatta 3743461 caaatgaacg tgttgaaggt cttcgggatg ccactcgcgc cgattatgac aggttattcg 3743521 agcaaatgaa cacgcaggag aattaatttc tcctgctttt ttcatatgaa tttcttacaa 3743581 atttgagcaa acctattgcg attatttgtt gaaggtatac aatagaatat aattattttc 3743641 aaataagttt gataatataa acaatttaac agcagggaga ttgaccatga ctaaacaaac 3743701 aattcgcgtt gaattgacat caacaaaaaa accgaaacca gacccaaatc agctttcgtt 3743761 cggaagagtg tttacagacc acatgtttgt aatggactat gccgcagata aaggttggta 3743821 cgatccaaga atcattcctt atcaaccctt atcaatggat ccggctgcaa tggtctatca 3743881 ctacggccaa accgtgtttg aagggttaaa ggcttacgtg tcagaggatg accatgttct 3743941 gcttttcaga ccggaaaaaa atatggaacg cctgaatcaa tcaaacgacc gcctctgcat 3744001 cccgcaaatt gatgaagaac aggttcttga aggcttaaag cagcttgtcg caattgataa 3744061 agactggatt ccaaatgcgg agggcacgtc cctttacatc cgtccgttca tcatcgcaac 3744121 cgagcctttc cttggtgttg cggcatctca tacgtataag ctcttgatca ttctttctcc 3744181 ggtcggctct tattacaaag aaggcattaa gccggtcaaa atcgctgttg aaagtgaatt 3744241 tgtccgtgcg gtaaaaggcg gaacaggaaa tgccaaaacc gcaggaaact atgcttcaag 3744301 cttaaaagcg cagcaggtag ccgaagagaa aggattttct caagtactct ggctggacgg 3744361 cattgagaag aaatacatcg aagaagtcgg aagcatgaac atcttcttca aaatcaacgg 3744421 tgaaatcgta acaccgatgc tgaacgggag catcctggaa ggcattacgc gcaattcagt 3744481 catcgccttg cttaagcatt ggggccttca agtttcagaa cgaaaaattg cgatcgatga 3744541 ggtcatccaa gcccataaag acggcatcct ggaagaagcc ttcggaacag gtacagcagc 3744601 tgttatttcc ccagtcggcg agctgatctg gcaggatgaa acactttcga tcaacaacgg 3744661 tgaaacagga gaaatcgcaa aaaaactata tgacacgatt acaggcattc aaaaaggcgc 3744721 tgtcgcagac gaattcggat ggacgaccga agtcgcagcg ctgactgaaa gcaagtaaga 3744781 aaaaagccgg cccattacag gccggctttt tttacgcttc aattttgttg aaaaactgcg 3744841 gcagatacgc tttgtgcgcc tctagcattt cgtctaaaat ctgtttggcc acagtatcgg 3744901 acgggacaag cgggttaatc gtcatggcaa ggagcgcagt ttgatagtca cctgtaactg 3744961 ccgcttctgc cgcgacacgt tcaaaggatt tgatttgctg gacaaggccg cggacagaca 3745021 ccggcaagtc gccgacagca attggcttag ggccggtttt cgtcatcaca cagttcactt 3745081 caactgcgga atcgtctgga atactcgcta ttgcaccatt attgatcgtg ttcaccggct 3745141 gaatgtcatg tttatcatta taaatggagc tgattaagtt acatgctgca tcactgtagt 3745201 aagctccgcc ccgtttttcc agctgcggcg gtttgatcgc aaggtttgga tctttataaa 3745261 gctcgaacag ctctttttcg accttctgta cgacttcagc gcgggtgccc tccgtttgtg 3745321 atgcttccag ttcgtgctcc agcatctctt ttgttttaaa atagtaacgg tgatagccgc 3745381 aagggatgac attgagcgct tttaagaaat ccggttccca ttcggcgcct gagatatttt 3745441 tcatcgtcat cgcgtttttc gggtcgccca tcgcctcgat gacttgctcc ttcacactta 3745501 cgccgtccaa gaaaacatcc agcccgaata ccatatggtt cagtccggca aattggactt 3745561 ctacgcggtc cacatctaca tcaagcgctt tggctacgcc cattttgatg ccgattggaa 3745621 cattgcaaag accgacgact ttcttcaggt tggagtagcg aagcaaggct tctgttacca 3745681 tgccggcagg gtttgtgaag ttaacaagcc aagcgttcgg gcaaagctct tctatgtcct 3745741 ttgcgatctc aaggatgacc ggaattgtgc gcaatccttt aaacagacct cccgggccgt 3745801 ttgtttcctg gcctatcact ccgtatttta gcggaatgcg ctcatccttt gctcttgcct 3745861 gcaaaagtcc gacgcggaat tgggtcgtga caaagtctgc gtctttcagc gcctttctcc 3745921 ggtcgagcgt aagatgaatg tcaatcggga cgccagcttt ttcaaccatc cgtttggcga 3745981 gtgtgccgac aatattcagc ttttcttcgc cctcggggat atcgacaagc cataattcac 3746041 ggacaggcag ctcatcatac cgtttaatga acccctccac tagctcgggc gtatagcttg 3746101 aacctccgcc aatcgttaca atcttcaatc cttttgtcat atgcttgctc ccctttgctc 3746161 ggtgattttt tcatataact caatgatctc tgcagccata tccttcactg tcattgcatt 3746221 cattaaatga tcctgtgcat gaaccatcag aagcgtcatt tccgtctttt ctccgcccgc 3746281 ttcattttgg atcagctctg tctgataatg atgggctttt gacaattctt cagcagcgtc 3746341 ttgaagcttt ttccgcgctt cttctgcgtc accgcttttc gcagcggcaa tggcctccat 3746401 tgcggagctc ctaccgtttc ctccgtgaag gatgatttga aaaatgattt gttccatttc 3746461 ctcattcacg cgattcactt cctttctcta cagagccgct tctttgtcat ctgttgctgc 3746521 aggcgtttgg accagctcca gatcgttttc ttctttcagc ttctgcttat cccacattct 3746581 gaagaatgga tagtagacaa caaaggacac ggcaatatta atggcttgca tgaccgcgcc 3746641 tgagactttt cctcctgtcg ccaagtagcc tgaaaagatc ggcggcatgg tccacggcac 3746701 tgcgataccc gccggtttgg cgacaaggcc ggtgctcatt ccgatgtacg tgagtgtcac 3746761 tgtgacaagc ggcgtgatga taaacggaag taagagcatt gggttcatga cgatcggcat 3746821 tccgaatata atcggttcgt taatattgaa gatggccggg ccgaccgcaa gcttcccgag 3746881 ctgcttcatt tgtttgcttc gggcgcgcag gaacatcgtg acaaccagtg ccaatgtggc 3746941 gccgcttccg ccaatattga cccagatatc gaaaaattgc tgggtgaaaa tcttaggaag 3747001 ctcctcaccg gcttggaatg cgatccggtt ggcatccatt gcgccgtacc aaatcggtgc 3747061 catgacgccg ccaacaatgt ttgcaccgtg aaggccgcag gcccataaaa gcattttgac 3747121 ggcttcggcg acaaggcttc ctccaaggct tcctcccaga atggaaagcg gagtccccaa 3747181 taaaacgctt acaatattat gaaggctttc aaacggtgtc gcttcaacaa tcagccgggc 3747241 tgcccaaatt aggaagatga cggcaaagcc ggggattaac gcgacaaatg acttgcttac 3747301 cgccggcggg acaccgtccg gcattttgaa gactaaattg cgctggataa taaggcggta 3747361 aatctctgtg gacaccattg cgataatcat ggcgacaaat aagcctttgc ttcccatgag 3747421 cgaaagcgga atcccgccgc caaccatgat ttctttcgtc gcgccatccg gcataaacgg 3747481 cacttgataa ggtgttgcta ataaaaatgc cgcaagggaa atggctccgg ccgacaaggc 3747541 atcaacaccg tatttctcgg cgagccggta ggcaatgccg aacgcggcga caagacccat 3747601 aatttcaaag gtcgcgtcga ctgggtaggc cagtttttca gaccaggagc tgccaaacgt 3747661 ttttgccata aactcagcgt atcccgggat cgggaggttg ccaatgatga ggaaaaagga 3747721 accgatgata atcaggggca tcgtgaggat gataccatca cgcagcgcct gcaaatgacg 3747781 ctgtcccgca attcttcccg ctataggcat gaccttttct tctaagatct gattgacttt 3747841 attcacatag cccgcccctc tctatgacac atgtccaagc tgttcagctg atttcagcac 3747901 ttccgcccca ttgcacgttc cataatggac ggtattaatg acgtctaccg gaaccccctt 3747961 tgactctcct aattttttga gctgcggaag catgtaacgg acttgcggac cgagaagcaa 3748021 tacatccgct ttatcgatat gattttgtac agaatcgcct gaaactgccc aaatggtata 3748081 gtcttttccc tgttcctgcg cacttttttc catcttgctc accagtaagc tagtagacat 3748141 gcctgctgca caaacgagta atatattcat gtaaaagacc ccctagagtt tgatcaattt 3748201 tgtaatgtcc tgctgttgct atcatcatat tatgaaatcg ctttcataaa cactcagggt 3748261 ttttccgcag gcaacggaaa aaaggtatat acaggctgtc agctcagcat tttttggtca 3748321 aacacatccg aaagctcttg atatgaacgg catttgatca gctggttcat cgccgccggg 3748381 tcatccaaaa tgctgccaag cagtttatac atgctttgta aatccgcttt gttctccttt 3748441 tcgacacaaa gcagacagac aaattgaact cgctgactct cccaatcgat cggttttttg 3748501 agcgtacaaa cggcccaaaa cgttgttttc gtctgcggaa caagcgggtg cgggatggca 3748561 acaagattgc caaaacacgt tggcgacatg tcttctcttt caaaaatgga atctatgatt 3748621 tcttcatcgg caaagccgca ttcgaccact ttctgcccta aaaattgaat cacttcttct 3748681 tttgagcgca gatcctcctg aaaaaaaacg agttcttttt ttaggtagcg attggctttt 3748741 tccttttcat cactcagaat agattctatt tttgtaaagt cagttccgcc taagatggtg 3748801 ttaaccttca gtactggtac agggagctct tttttaatcg gaatggtgct gatgacaaaa 3748861 tcaattgatt cgtaggacat ttgatcaaga ctataatact cagccgttcc aagaatatcg 3748921 agccgcttgc cgaaatggga acgcagtttt tcgcgcagaa gctgggcgct tccggctccc 3748981 gatgcgcata caatgataca gcgtttcggc gggctttctg ttttttttcg ttcaatcgcg 3749041 gcgccaaagt ggagagccaa atatccaatt tcgttttcat gaatctcaat acccgtttgt 3749101 tcctttatca cgattccggc aatgatcccg gcttcaaaag cgagtggata atgttccttg 3749161 atcgctgcca gcatcggatt tcgaagattc atgccgtatc ggttgcggct gatcgccggc 3749221 ttcatatgca gtgccaagcc gattttcagc tctttgtcat gcaggatgcc aagcttcagt 3749281 tcacgatcaa cagctttgat catggcaagt gtcagctgat cggtttcctc ttctattgaa 3749341 aatgtgtcct ctccgcattg tgattgtgtc attcgttttg tgccaaggag atgcatggtg 3749401 atgtaggccg tctcgtcttt cggaaacgta acggaaagct ttgattccag ctcttttacg 3749461 atggcttctg cagcctggta ctccttttga tgcaggatat gatccatatc tttcgggaaa 3749521 agagaaacat agttttccgt tctgatccgt ttacaggcga tagcgatatg gataatgagg 3749581 ttattcagtc ccatgttgga cagagggatg cggtcgtttt tcattttttt caagatggcg 3749641 gaacggatga tctcaatttc ttcttttggc aaaatatcag ccttttcatt taaaacatct 3749701 atctccgttt ctctttcatc aacaatgtac tccgccatgc agtacctcat ctgcacctcg 3749761 tccccgcgca gcttgaagcc gtaattcgga cgtgtttcca tgacgatgcg gtaaggcagc 3749821 agacgtttct ttacttcctt taaatccgtt tggagtgtag attttgagat aaatagttct 3749881 tcagcaagtt catcgagctt gagataatgg tccgccagca gcagacgttt cataagatag 3749941 gccattctct cctccggcaa taccggcagg cccttttttt gctgaaattc atcttgcagc 3750001 agtgttctga atacttgctc gtcatcaatg cggagcttgt agccggagcc tcttacagat 3750061 tgtacaaagg caccgtggcc gcttagcaca ccttgaagtt cctttatatc attgcggact 3750121 gtccgcgtcg ttacgtttaa ttgcgcggca aaaaacgaac ttgtcaccgg ggcttcagcc 3750181 gccatcagca agcgcagaat atcacgtagt cgcccatgaa gcatgagaaa aacctcctaa 3750241 ctagtagatg cagggattca gtgaataggc agaaaggatg atgaagggat gcgaaatgta 3750301 tataaattct ataatggaga gaatggcaag tcaatgaaca tccggaggac tagagggaaa 3750361 actgacctat aaaaaaacag ccgggatcag ccggctgttc tagatgcgga catattcttt 3750421 tgtttagacg ccttgcggtc cttcatgatt tttcgaacaa tcgggtaaat gaccggcgcc 3750481 catttgataa cggttttgat catctttttc aaagctccga ttctcccttc ttttttctca 3750541 accattcccc tgattgcctc ttccttaaac atgctaacgc gacacgtacc tgtttcccgt 3750601 cacccagaaa cgccatggat aatcgcgtgc ctccccgctg ttgtcaatgc cgatgcgcgg 3750661 gccggttgaa attgcttccg gtgtgtaccc gctttcgatg taaagcggct gttccgtgat 3750721 ccagcgtccg tagtcattca tcgtgacgcc aagcgctttc gtcagctttc ctggtccgtt 3750781 tgtccattcc ctcggactcc tgcccggcct tctctcctcc attaacagct ggccttcatg 3750841 cggctcaatc gccctgatta atactgcttg cgggacatcc tcttccgccg caacgacatt 3750901 cagcaatgta tgggtgtgca tcacgtatgt atatacccgc ccagcttctg caaacatgat 3750961 ctcagtccgc ttcgtccggc ggttgttaaa gctgtgggcc gctctgtctc cagcccccat 3751021 ataggcctct gtttccacaa tatagcctga cgctgtgcct tcgtctgttt cttttacaag 3751081 aaggcagccc agaagcgatg gggcaagctc aagagcggtt ttttgataaa acgtgatggg 3751141 cagcggattt ttttctctcg tcacgaatcg acctctcctt ttaccgattt ttgtacattg 3751201 taccattccc gaagcagatc aaaaaaaacg gctgttttaa aatctttcca ttcagggaat 3751261 attgttaccg ttcaaaaaag gagggccaac cattgaaaga tgatcatcaa aacaagcagc 3751321 accaatcaaa tgcccaaggg agcgaggaag cgttttctca taagacatcc gggaaaaacg 3751381 agtcagagga taccttaacg aataggcagg ggcatcctgt tactgacaac cagaatgtga 3751441 gaaccgtcgg gaatagaggg cctacaacac ttgagaacta tgattttctc gaaaagatca 3751501 gccacttcga ccgggaacgc atcccagagc gggttgttca tgccagggga gcaggtgcac 3751561 atggatattt tgaagcgtac ggaagcttcg gagacgaacc gatttcaaca tacacaaggg 3751621 ccaagctctt tcaggaaaaa ggcaagaaaa caccggcatt tgtccgtttt tcaactgtga 3751681 atcatggaaa acactcgcct gaaacattga gagacccgcg cggttttgct gtaaagctat 3751741 atacagaaga cggaaactgg gatttggtcg gaaacaacct gaaaatcttt tttatccgcg 3751801 acccgctgaa atttccggat cttgtacacg catttcagcc tgatccagtg acaaacatcc 3751861 aggatggtga acgtatcttc gatttcattt ctcaatctcc tgaagcgaca cacatgatca 3751921 ccttcttgtt ttcgccttgg ggcattccgg ccaactaccg gcaaatgcag ggttcaggcg 3751981 tacatgccta taaatgggtg aatgaggagg gcaaggccgt tctcgtgaaa taccattttg 3752041 aaccgaagca gggcatccgc aacctgacac agaaggaagc agaagagatt caagggaaaa 3752101 actttaacca tgccacacag gatctatatg acgcgattga aaatggcgat tatccagagt 3752161 gggaagtata tgctcaaatc atgagcgatg atgagcatcc tgaactggac tttgatcctc 3752221 ttgatccaac aaaactgtgg tataaagacg atttcccatg gaaaccgatc ggcaaattgg 3752281 ttctgaacaa aaatccggaa aactaccatg cggaagtgga gcaagcttca tttggaacgg 3752341 gagtgcttgt cgacgggctt gatttttcag acgacaaatt gctccagggg cgtacgtttg 3752401 cctactctga tacgcagcgc taccgtgtag gcgcaaatta cctgcagctt ccgatcaact 3752461 cgccgaaaaa gcatgtcgcc accaaccagg aaggcgggca aatgcaatat cgggtcgata 3752521 gagcagaagg acaaaacccg cacgtcaact acgagccatc cattatgggc gggctgaagg 3752581 aagcgaagca agacggaaaa gaccatacgc cgcatgtcga aggtgatgta aagcgtgaag 3752641 cgattgacag aacaaacaac ttcggacagg ctggagaaac gtaccggaga tttactgaat 3752701 ttgagcggaa cgaattgatt acgaatttgg tgaatacgct ttctacgtgc cgaaaagaaa 3752761 ttcaggatca aatgattgag aatttcacaa aagctgatcc tgactacgga aaacgcgtag 3752821 cagaagggct aaaaaaggtc tccgaaaaca acagcaacgg gccgatcggc acaactgaaa 3752881 cggaacaggc tgcaaagcag gctgaacagg agagtcatcc gtctgatccg tattaacaac 3752941 agcgaacagg gcttttttag aagccctgtt tttttatttt tctattgaaa cgctttcaat 3753001 aattgtgttg tacttggaag gaaaggggtg gagagatacg atggaattac agcaggactt 3753061 gattcctcag aaaaaaacaa tcggcgcttt agatcacgcc gtttttttat gcatggtatt 3753121 ttgtttctgg ttttcaggct atatttacgt tcctgtattc agtctgtatt tggaggatct 3753181 gcacttttca tatggcgcaa tcggcatcat tctcggcagc tacggggtca cgcaaatcct 3753241 tctgcgattc ccgctcggcc ttttgtcaga catcctgttt tccttgcgca agcaattgtt 3753301 aattgccggg ttcggctttt ccgtcctcag cagcctgctt tttctgatgt ttgattcttt 3753361 cttcttcgtg ctggccgccc ggcttttcgc gggaatcact gcttctacgt gggtgatggc 3753421 gaccatttta tacgcacatt atttcaacaa tggcaatgca tcaaaagcaa tgggcatcat 3753481 gcagtttttt accgtcatgc ctcagtttgc cagcattgtg ttctgcgggc tcgccgcagc 3753541 ccatttaggg aggcaggttc ctttttggat ggcgctggca gcttctgccg caggtctggt 3753601 gatctgctgc tttattcagg atccgtctgc tcctcccgca aaccgtggca ccattcgtgt 3753661 caatcagtac atcaaagata cattgcggct gccaaagctg aagcttttca ccatcctgtc 3753721 tatgacggcc catgccgtat tatttatcac agtgtttggt tttacgccgc tttacatgaa 3753781 tcagctcgga atgggcgacg cggagctgct ttgggtgatg agcgcctttt tcctcccaca 3753841 cgcagccgcc acattaagct ttgtgtttct gcgctttaca agccgtatcg cttactccgt 3753901 gatgctcatt agtttcgctg tcaccggggt ctgtttgcta tatgttcctt ttttagctgc 3753961 attgttcacg gtttgcatca cacacgcctg tattgggctg gcgctcggct tcgtttttcc 3754021 tctgctgcta agccatgtcg tcgaaatcag ttctgcccgt ttaaaaatgt cagtgatggg 3754081 gttttaccaa tcattttatg cgctaggcat cttcctcggg ccccttcttg ccggaaaaat 3754141 cgcacagctt atcgggcttg cgggagtttt ttatggagcc ggttctctgg catttgccgc 3754201 cttttttgtg atgctcgcgc aaaaacgtaa catgatcaat taatagcttt cataccgccg 3754261 gaagcgccac acagaaaaca cggccagaag catgatgcac agaatggaga aagtgagtga 3754321 ccatccgaaa aaatctgccc gctctccatg aagaaggata tgctccgcct gcttgcaaat 3754381 ctcagccgga agccacttcg caccatctgg aaatagtgaa acagcaaagg aaacggctgc 3754441 tgtgagcccg atcccgcaag ccgcagctgc tccgacagac cggaatatcg tacttccggc 3754501 aaggccggcg gtcacaataa atatcaccca aagagcgtaa aggccaaggc ttgcggcaaa 3754561 gcggctgaat gatgcgtcct caaacagcag ccggacgtaa tagtaagcaa gcccgtatcc 3754621 agctgcaaac gacataatgc cgatcacgct ttggatgagc catttactca cgatataatg 3754681 ggctgccgtc acaggccgcg acataatcag cgctgttacc ccttgatttc tttcattggc 3754741 tacactgccc atcacgctaa agatgaccag agccatgcca agcgtgttga attgagaaag 3754801 cgtgctgacc atcacttcag acccggaggg catcgtaaaa ctgattttca tgccgtcagg 3754861 aaggttccct ccatgtgcga tgatttccgg catataataa atggtcagcg gctgtgtcag 3754921 cccgacgatc atcatcgcaa tcggcagcca aatcagcttg ccgcttttcc atccttccag 3754981 ccactccttc tgcaatagcg ccatcatcac cttcatgcgt gcaccacctt tagatagacg 3755041 tcttctagag actccgtttt ctgttcaaag cgggtgacgg tcaatccctt tcggatacag 3755101 tcacttaata atgaccggcc agcgtgtata tcaggcagct cgaaaaccgc ttgggacgga 3755161 ttcttataga caatagctga gacgtaaggc ttctcttcaa gccaaccttc cagcttctct 3755221 ttcactgaaa gggtaaaaac gttcgtttgc tgctgttgtt tcagctcctg taactcgcct 3755281 ttccatgaaa tctcaccgtt tttcataatc accacttgat cacacacctg ttctgcatcg 3755341 tgcaaaacat gtgtagaaaa cagaacggcc atatgctttt tcagctcccg catcatgtcc 3755401 agcacctcga accgtcctgt cggatcaagc gcagacaccg gttcatccaa tatcaaaaac 3755461 ttcggtttat ggagcagtgc ctgtgccaga ccgagtcttt gtttcatgcc tcctgaatag 3755521 cccccgatcc ttttgtgcgc cgcttcgtgc aaaccgacaa attccagcat ctcgccgatt 3755581 ttctcttggc attttctctt cgaaaggccg gacagtctcc ccgcaaatgt caaaaattca 3755641 tttgcggtca tccacgaata aaaagcagga tactgcggga ggtacccaat caaacgccga 3755701 tccagctttt tctctcctaa cagctttatg gttccagagg ttggcgaaag cagtccggcc 3755761 agcatttgca gagtcgtggt tttgccggct ccattaggtc ctaatagtgc gacacactca 3755821 ttttcattca cgtgaaaact gacattcttt acagcttcat ggtgcctgta cgatttgcat 3755881 aatgattcaa tagacagcat atcggcttac ctttgctttc tgccgacggt gaaaaataaa 3755941 atcggcccga taatattgat acatacgatg attgcagccc acatccactt tggcccgttc 3756001 gtccgctctt cttttataca gctgataagg gcaaacaccg ccaaagccag ctgtaataca 3756061 atcagcggca aaatcatttc ccaagaaata ttcattgctt gatccccctt ttcttccgat 3756121 ccggcctaat gacaaaaaag taataacaaa tcagaggcat cggtgcttga atcaatccga 3756181 caatccccca aacccatgcc atgtgattac gttttttcgc atcaataaat aaaaagattc 3756241 cctgcgccaa tacgatgaga caagccgcaa ccgttatgat aatttctgtt tgtgtcatcc 3756301 gcgtttcacc tcgcattcgc cgagatgcct ttttttctca gccgcaatca aaatcggcag 3756361 caccgcaagc acacaaacct gaagcacaat aaacacagca ggagcttgag tgaaagctaa 3756421 gattgcagca ctcacaacca tcagcgcgca gaatacaaat aaaatgatct cttgaagaag 3756481 tttttttctg tattcagctt tcatttgtga cagctggtga agcagttctt tttgattcgg 3756541 tatagaggga ttggctgttt gatcaatttt tttccattct gactttaaat gatcagaaag 3756601 cttttcttta ttcatcatcc cactcctttc tgatttgctg gagcccttta tgaactctgg 3756661 actttacagt gccttctttg atttgaagca tcaccccgat ttcagcgtag gtatagccgt 3756721 agtaatgcct taataaaacc ggtgtgcgca gtttagggtc cagctttgaa aacagatcga 3756781 gcgtttcgct ccactctgcc cctttcgccg acacgtccca cttgatcttg cggattgttt 3756841 cctccgtaac tgtctgattc cgtttccatt ctctctttct ctttttctgg tgatcgagat 3756901 agagccgcga tgcaatggag atcagccatg tggagaattt tgaacggccc tgaaagcttc 3756961 ttaaatggat gtaccctttc agaaaggttt cctgaacaag ttcctcgctg agatcggggt 3757021 gaagggaaag ctttaacaag tatttatata agaaagaata gtgatagtgg aaaagggctg 3757081 taaacgcctc gtcgtttccc tctttcgcct gctggatcag ccgctgttct tcttgtgtat 3757141 ccaatgaccg tgatcccccc ttttttgttt ttctgcctta tgagacgaca ccggattcaa 3757201 aagcgttcat cttttttaca attcttttca gccattgaca gatcaggctt cccggccgtt 3757261 tggctgcata tccttatttg taaaccccct tatagtctgt taagctatga ctttatgtcg 3757321 atttcaaaaa aacatccaat atggaggacg atgcattgaa agtagaaagg cgaacgattg 3757381 aatatattcc gaatgaagaa agacatggta aagcgaaaga tttatttccc gtatggttcg 3757441 gggctaatat gcatatcacc acgttagtga ccggcacgat tcccgttgca atgggactta 3757501 atctgttttg gagtgttgcc gctattattt gcggaacctt aatcggtgcc atatttatgg 3757561 cttctcattc cgcgcaaggc cctcagctag gcatcccgca aatgattcaa agccgtgccc 3757621 aattcggcgt aatcggagcg attcttcccc tcttcttagt catgtttatc taccttggtt 3757681 tcttcgcaag cagcacgatt ctggcggccg gaaccttaag cagctttgtt cccatcccgg 3757741 gatcatggag cattataggc ttaagtgccg tatgtttttt actcaccatt ttcggccatg 3757801 atttgattca caaaatgcaa aaaatccttt cttggacctc ttttgctgta ttttttgctg 3757861 caacgattct catttttcaa ttgccgattc cggcaggcag ctggataccc ggagcgattg 3757921 atctgccaat tttcctagtg gcagtcagcg cagttgcgac gtggcagctt gcctacgcgc 3757981 cgtatgttgc cgattattca agatatctgc cagttaaaac accggcttca aaaacatttt 3758041 ggtacagcta tgcaggtaca tctgtcagct ccatctggat gatgctgctc ggcgcattgc 3758101 tgacaacctc acttcctgac tttacggcaa actcaggcag ccagattgtc caattgttcg 3758161 gtcccttctc gtttattatg ctgatcattg tgctatttgg gcaaatggca atcaatgttt 3758221 ttaacctgta tggggctttc atgtccacga caacaacgct ggagccgttt ctgaaattaa 3758281 aagtcacgcc caaagtcaga atcatcatga tcctgggtgt cacgcttgtc ggcacagtct 3758341 taagcctact gggacagagc aattttatgg aactgttttt gaattttatc tttttcatca 3758401 gttatttctt aattccgtgg acggcaatca atttagtcga ttactacttc gtccgccacg 3758461 gaaagtatca agtcaaagcc atgttcgacg taaacgggcc ttatggaaag gtcaattgga 3758521 tcaccacaat tgcgttcgtt ctgtctatct tgctggaaat tccgtttatc aacacaagct 3758581 tttacatcgg accgcttgcc aaaatgtttg gcggcggaga catcgcatgg attatcggct 3758641 tggccgtgcc ttctgtgctt tactatgtat taatgaaacc gcgtctgaaa aaacgggcgg 3758701 ggtatcaaga aaagctgtct tctctctgaa gacagctttt ttatcattca aatcgtttcc 3758761 acacgcgggg caggatgtca gatagctcat gagcgagcaa cgtatgagcg gagtgctcgt 3758821 ccgtccagag ctcggcgcac gcaccatgca aatagaccgc gtttaatacg gcgtgctttg 3758881 gatcttcatg gcagcagagc atccccaata tcatgcccgt cagcgtgtca ccggttccgc 3758941 ccttggcgag cgccccgttt ccggttggat tgagccagca gtctccatca ggaaacgcga 3759001 tgacggtttg gtttcctttt aacacaatga cagtctgcag ctgagccgcc cattcctttg 3759061 catattccgc tctttttttc tgcaattcgt tcacgggcac ccctgtcatt cggaaaaact 3759121 cgcccgggtg cggcgtgagg atgacggggc cctcccgttt cggatatgtg cgcttcgcca 3759181 gcgctccggc atccaaaata acaggacaat cagccgtaag cacatgatcg actgcctgct 3759241 gtacgctttc cgtttgcgga aggcccggtc cgatggcaat ggcccggtac gtctcttcaa 3759301 gctgagcatc cgccgccttt ttccagccgt cacgccaata ggtcgcctcg ggcaaaacag 3759361 gaacaattag cgggattacg ttttctgatg taccgatgac aagcttgccg agaccgctcc 3759421 gcatggcccc aagccctgca agcagcgctg ctcccggcat gtcgtcactt ccagccagca 3759481 gcaaagccgt accgtacgtg cctttatggc tctccgcatc tctttcagga agcgtggccc 3759541 ttacatgctc ttccgtccaa aatggaacat tcatctctat ccctcctctg ctttcttttc 3759601 ctatttttcc tgtccctttt ctttttcaaa caaaaaagac agccttttag ggctgtcttt 3759661 tattttacag gaacatcaag gtgatacagg cggcgatatc gttcgtttgc cgccagcagc 3759721 tcctcatggg ttccttccat ttctgttttg ccgttttcga gaaatacgat tttatcggct 3759781 gcttccactc ccgcgagatg gtgtgtaatc cataaaatcg tttttccttt cagcacctca 3759841 aacaccgttt ccatcaattc acgttcggta ataggatcga ggccgactgt tggctcatcg 3759901 aggatgatga tcggtgtatc ctgcagcaaa atcctcgcaa gtgcgatccg ctggcgctct 3759961 ccaccggaaa aacggatgcc ggtttcttgt acagaggtat gatatccgtc aggcaatgac 3760021 tcaatgtagt catgcagctt gacctgcttt gcggcgcggc gcacatcctc gtcgcttgct 3760081 tctccgtttc cgagcctgat gttgttcaaa atgcttgtat caaacaggtg cggtttttga 3760141 tttaacacgg ccaccgcatc cgcaatctga tcctttaaca gcgctgtctc cactccgttt 3760201 aacgtcacag aaccggagtc cggtttcaag gcgccttcga ttaatgcaag cgatgttgat 3760261 ttcccagagc cgcttcggcc gagcagcgcc attttttctc cttggcgcag cgtaaaggaa 3760321 aagttgtgca gcacttggct gctgttgtca taagaaaacg tcacatcacg aaaggccaag 3760381 gtgacatctt gaagatcgag aatttgatcc cctgattcag tttgtgacgc ctccggctga 3760441 ggagccacat tgttcatgcg tctgatagaa tcctgatagc ccggcacttc gcctaaggca 3760501 tccgaaagcg gcaaaaaggc ttccgtcaac ggaaacacca ctagcacaaa agcggcaatc 3760561 atcgttttag cgagctcgcc gtccgcttgc tgtcccgctg tccaaaacag catcagcaaa 3760621 ataaggccag cgacaaggca ttgcgcagca aagtcccgcc atcttgtaaa gcgttgtttt 3760681 ttccgttcaa gctcaaacca atcacgttcc tctttttcat aagcatcaat aaaagcatgc 3760741 cggcgtccgc tgaacatcca gtcgctgaca cccatcacag catctgtcag acggctgtac 3760801 agcacattcc gtccgctttt cagcttcgca ttcttcgctc tcgtcacgag caaagacaca 3760861 accggaaaca atacaacaag aacaaacaaa tacagcgcaa gcaatatggc aaacggccaa 3760921 gagaagaagc cgagcgctat cactgacaca gcatacagga gcaaggctga gatcgcagga 3760981 aaaatcgttt ttaagaaagc atcctgcaaa tgctcaatat cctcagacaa aatgccgagc 3761041 atatcccccg tgcgaaaacg ggaacgcagc atcaaagcac ccggctcaag catattgtaa 3761101 aggcggacgc gcatgtcaga tacgattttc aaaatgatgt gatggccgac gagccgttcc 3761161 acatatcgcg acacagagcg cgcaatccca aaggtgcgca cagcgacaat cggcacataa 3761221 atgagcagaa tgttttccgg ccttgtcgcc gctttagaaa tcaaaaaacc tgaggtgaac 3761281 atgagaaaag cagcagaaaa aatcgtcacc gcacccaaaa agataaccag aacgaacagg 3761341 cgggcatttt gcttgatata cggcaaaatc cattcttctt tcttcatgct ctttccccca 3761401 gttgtgcctt cacgagtttg gtatacacac cgtttttctc cagcagttca ttgtgagtcc 3761461 caatttccgc aaccctgccc ccgtcaagca cgataatttc gtccatatcg agcatccagt 3761521 gaaggcggtg agtcgcgaga aagacgagct tatcctcaaa taaatccagc atcgtttctt 3761581 ttatttcata ttctgtttcg atatcaagat gggcggtcgg ctcatccagc agcaggatcg 3761641 gacggtttcc caaaaaggcg cgggccagcg cgacacgctg tgcctggccg ccgctgagcg 3761701 cccggccgcc ttccccgatc cgcccctcta atccgtcagg aaggttgttc accagctccg 3761761 tcagtcccgc tgaggcagca gcacgtgttg tatcctctgc cgaagcgctt ggatggtaga 3761821 agcgaatgtt gttgccaagc gtatcatcaa aaatgtacgg atgctgggga atgtaaagaa 3761881 ggttcttctg ccagctgccg tcctgcaaat gggaccggct tgtaccatta acctcaatca 3761941 tcccgccatc cggctctaaa aatccgccga gaatatcaat taatgttgat tttccggcgc 3762001 cgcttgcacc gataatgccg atttttttct tgcctttgaa tgagagatga atatcagaca 3762061 ccgaacggcc gactgacacg cctgacagct tcagctcatc ctgatcggac caagcttcga 3762121 gctgaagcgg cgtctcttct ttaaaaccag gctgcgacaa aatctcttga atggtttttc 3762181 ctgcttcctg gccgttcagc gttgcatgat aatcattccc cacttcccgc accggcaaaa 3762241 aatactcagg cgccagaata agcgccgtta aagcagggcc aagcaaaata tcgccgtcaa 3762301 tgaggcgcag gcccagaaat actgcgactg tcgccaccga cagcatcgtg aaaaaatcga 3762361 gggcgaatga tgacaaaaac gccacccgga gtgtgctcat cgttgccttg cgataccgct 3762421 cactcacata gaaaatattt ttgctgtgtg acttgctcaa acctaggaaa cgcaatgtct 3762481 ccagcccgcg aagagaatca acaaaatgat tggaaagtct ctgataggat ttccactgac 3762541 gatccgcttt tctctgcgcg acaaggccga ggagaatcat aaagatgatc agaatcggca 3762601 tagcagcgac taaaatgatg gctgatgtcc gatcctgaaa aaacacataa atgacaactg 3762661 ccgcaggcac aatcgccatg ctgaccattt tcggcagaaa cagctccagg tagcggcgga 3762721 actggctgat gccttccatc gccagcgtca ccatttgccc cgtcccctct ttctttgcaa 3762781 agcgggggcc taatcggaac agctgatcaa gaaaactttt cctcaaatct gctcctgtcc 3762841 gggcggcgta ttgatagacg attttctgtc gcgccaccgt catcccgtgc cgggcgataa 3762901 aagcgatgag gaaaaagccg atcaccggta aaagggaggt aatgcccttc ccgttgaaca 3762961 gtccggttac ggcctcactc agccactctg cctgcataat aatggcggct gtctgaatca 3763021 acgttaaaca agtaatcaag gtgagaatcc gcttcattcc tttatatcga aacaggtctt 3763081 ttcccattaa taagtcatag gctccttatg gctgacgcgc ttccggaaga cataatagct 3763141 ccagatctgg ctgccgatga cgaacggcaa tagcgttaat gctgcaattg acatgacttt 3763201 aagcgaataa tctccagaag aagcgttagc tactgttaaa tcgtatgcgc tatgaagcga 3763261 gctgaccatt acacgaggga atagggaaat aaagatcatt cccacggtca gcgccagacc 3763321 agcgcctgtc atcccaaatg tccagccgtc ttttttctta cgaataaata cagccgcgag 3763381 cataaagcag atgacaatca aaacagcgag cggaatggta atctcgccgc ggcgtgtaaa 3763441 catgtctgtc tgatacgcag aaagggccgc gaaggcaaga accgctacaa aaacaacacc 3763501 cattatcttt tgcgccattt tccgggcgcg gttttgcaaa tcaccaatcg tacgcagcgt 3763561 gataaacatt aatccatgct ggaagcaaag aagcgttacc gtcacaccgc caagtataga 3763621 atatacattg atataatcag atacatgtgc gtgaatgttc atgtcggcat caatcggcat 3763681 cccgcggaat aatgtcgtga acagcacacc aagcacaaac ggaggaatta gactgccgaa 3763741 aaaaacgacc cagtcccaaa cctttaccca ttttaaatga tccaccttgc cgcggaactc 3763801 aaacgcgacc ccgcggccca ttaacgcaag cagcactatg acaaacggaa tgtaataacc 3763861 gctcagcatc gttgcatacc agtttgggaa tgccgcgaaa atggcgcctg cgccagtcaa 3763921 aagccacact tcattcgcgt cccagaacgg cccgatcgtg ttgatcagca ctctgcgttc 3763981 taattcatta tggccaagaa aacgggtcgc catgccgacc ccgaaatcaa agccttccaa 3764041 aaagaagaat cctacaaaca atacagcaac gagtataaac caaagatcat gaagagatgc 3764101 catggtatac ctcctgacta aatggatctg ttgatacagg cacatcatga tgattatcat 3764161 gctccgcacc ttttttaatc tcacggataa acaagaagac aagcagtgca ccaagaatca 3764221 tgtacatcac accgaatgcg atgattgaga ataacaagga acccgctgtt acgttaggcg 3764281 acacagattg agcggttgtc attaacccca taaccgtcca aggctgacgt ccgatttctg 3764341 tcataatcca gcccgcggag tttgcaagaa acgggaagga aatcaacgcg atcatgatgc 3764401 gcaaatacca tttgctgttt tcaagctttt tacggcggtt taaccaaagg ccgcctaacg 3764461 cagcaagaat catgacaaca cctgctccta ccatgatgcg gaagctccag aatgtcgttt 3764521 tcactggcgg aatgtagtcg ccttttccgt atattttttc gtactcagcc tgaagggttt 3764581 tcatcccttt gacacttccg ctgaatttct gataagccaa gtagctcaag gcataaggaa 3764641 ctttgatttc atttgagctt ttttcatttt ttgtatcgat cgtcgcaaaa gcggtccaag 3764701 cagcagggtc accgctgtct tcccataggc cttcactggc agccattttc atcggctgtg 3764761 attccatcaa gtgctcagcc tgcatgtgtc cgctaaggcc gacgccaaga ccggcacaaa 3764821 gaccgacgat cattgcgagt ttaaaagatt gcttaaagaa cggcacttct tttttcttca 3764881 gcagtttaaa agcactcact ccggcaataa agaaagctcc agtggcaagc gcaccgaaaa 3764941 taacgtgcgg gaattcaacc caaagctgag ggtttgtaat caacgcgcca aaatcattca 3765001 tttccgcgcg gccgtttttg atcgtaaagc cgaccggctc ctgcataaag gagtttgctg 3765061 ttaaaatcca gaaagatgac atgatcgttc cgaatgatac gagccatatg cagagcgcgt 3765121 gaattttctt cggcaggcgg tcccagccaa aaatccataa tccgataaaa atagattcca 3765181 tgaaaaacgc caataatgct tcaatcgcaa gcggagcgcc aaatacatct ccgacaaaac 3765241 gggagtaatc tgaccagttc agtccaaact ggaattcttg caaaatcccc gttacaacac 3765301 cgactgcgaa atttattaag aataagtgtc cccaaaactt tgccattttg agatacagct 3765361 catttttctt tacaagataa agagtctcca tcaacgcaac cataaacaca agcccgatag 3765421 acatcggcac aaacaagaag tgaaacaacg ttgttgatgc aaattgtatg cgggctaata 3765481 ccaattcact catgctttct cctccatttc cggttaaaac tgttaatttg ctcactactt 3765541 cacaaataga accgagactt tgatcagtaa ttcacaaaat agacgaaaaa aatattgctc 3765601 aatatttcac aaatgtgtca aaaagtcatc caatatgatg caagattgcc agactgacca 3765661 aatgacacaa tctctgactg gttcatatta agtactttac aacgattcat ttcaaaaata 3765721 aagcctaaaa tacctaaaaa gtcccgcact atgtgacgga tttttgtcta ttttgttgct 3765781 tatttatgtc ggctgctagg ataaatgacc ctttattatc gtacatcaac acatcgttcc 3765841 ttgcgaacaa aatgcttgcc cccgccccag cactcgagtc tcagcattcc gtcttaaacc 3765901 gattttagtc agaatgcctc ttttcatttg aaccggtaag aggagaaaag ttgaatagta 3765961 aatttttaat atattaataa tttcaatttt ttagtatact taacatagtg aacaatttca 3766021 ctgcatcaag aataggggag gtttttcaat gggagagctt caaacacaca tgcaattgca 3766081 aacggataca attcacgaag gggttcgaaa agagaattgg tttgcgaaag ccatgaatat 3766141 aaaagtaggc atcataccgc ttcctgtgta tgccttgctg tttatattaa tcactgtttt 3766201 tgttatgcat cacgatgtaa aaagtgacat tttgacatcc attgccgtca tggcgttttt 3766261 cgggtttacc tttgcccaaa tcggcaaatc gataccgatt gttcgttcta tcggcggccc 3766321 ggccatccta gctactttta ttccgtccgc tgtcgtgtac tatcacctgc tgcctaatga 3766381 tatcgtcaaa tccaccacag aatttacaga aaactcaaac tttctatatt tgtttatcgc 3766441 cggtattgtc gtcggaagca ttctcggcat gaaaagagaa acactcgtaa aagcattcat 3766501 gaaaatcttt attccgctta ttgtcggttc tgtcacagcc gctattgtcg gactggctgt 3766561 cgggacattg ctcggactcg gatttcagca taccctgctg tacattgtca ttccgatcat 3766621 ggctggagga gtcggagaag gcgctatccc gctgtccatc ggatattctg acatcatgcc 3766681 catttctcaa ggggaagcgt ttgcacttgt tctgccatcg attatgctgg gcagcttgtg 3766741 cgcgattatt ctagcgggat tgctgaaccg aatcggaaag aaaaaaccgg aatggacagg 3766801 caacggcaaa gtggaccgct ccgaagaaga gtcccctgcg ctggaggaat ctcaaagcgg 3766861 acagcaaatg ttcaaccttt ctttatttgc gtcaggcggt atccttgctg tttctttata 3766921 cttagtcggc atgctcgctc acgatttttt cggttttccg gcacccgttg ccatgctgtt 3766981 actggctgtt ctaatcaagc tgttcagatt ggtgcctgcc tcaattgaaa atggcgcgtt 3767041 tggagtgtcc cgcttctttt caacagctgt gacctacccg cttctctttg cgattggggt 3767101 atccatgacg ccgtgggaca agcttgtcgc cgcttttaac ctcagcaata ttatcacgat 3767161 tctgtctgtc gttgtgacca tgatggccgt tggcttcttc actggaaaat ggctgaacat 3767221 gtatccgatt gaaaccgcca ttattaatgc atgccattct gggcaaggcg gcacgggtga 3767281 cgttgccatt ttaagcgccg ctgaaaggct tgagctaatg cctttcgccc aggtgtctac 3767341 ccgcatcggg ggcgcgatta cagtatcctt aaccttattg ctgctgcacc agttttattg 3767401 atccccgcaa gcaagttctt cgtcaaacga aagagcttgc ttttttgcat gtccatgttt 3767461 ttgcaagttc ccatcccatg ctatagtaat agttggaaat actagataga aaggaatctg 3767521 gcatgcctat gggaactcat ctatttctct ttatgcttct cgggctggga ttttatttga 3767581 tatcagccct agctgcaaaa ctcattccgg ccatagactt ctggattgat attgttctat 3767641 gggtcggcgc tgcggcttac atcttctctc atctctcatt catggacggc attgtctcac 3767701 tcgcgacaat gttctactgc tattggaccg caatggatct cattgtttca gagcgtgtgg 3767761 aaaaaccttc gggagactgg caggaaatcg agcttgccaa aaacaaaaca cgcctcctgt 3767821 cagacattac gctgaccgcc attgtgtttg caggggctgt catttttttc atctatggac 3767881 ctgacacaag ccctctcaaa tatgtgatcc ttctcggaat gatctccggc ggaggggcac 3767941 ttgtgaagcg aatactgaat gtttttagcg taaaggtttt ttattcagca gccttagaaa 3768001 aattgcatat cagctcacac tatgaaaccc gtacataccc gctttccgat ttgaagaaca 3768061 ttcagcttga atcaacagca gatctcttaa agctccatcc gcttctgacg atgtattcat 3768121 cccgtttaga tttgacaaca agctttcagc aagtcattaa actgtctctt cccggcgaaa 3768181 cactgtttct gacggtgaag gaaccgcaaa aatggaaaac aattcttcag gaatacacag 3768241 atgcagaaaa caatgtggac aatgtgattt ctgttttgcc gttttatcat cgaaaaaatg 3768301 tgaagcggct gctcggtaag ctttattttg ccgccagcgt aaaaggggta tccgcttacg 3768361 ccttattggt gctcgcgtta tacgcattac acgcctctcc atgggtcatg gctgttgccg 3768421 taatcctata ttgggtattc aacatgtata tgtcagaccg tgtgttgcgg gcggcgatgg 3768481 acgccaagtc ttgtcatcat ccgcatgtac aggccgcggc cgataagatt ttcagatcgg 3768541 ccggcatttc ccatgtccgc atatacgaaa cggagagtga tgattacaac ggaatggcag 3768601 taggcatgaa tgtcgggagg tcaatggtca tcctgacaag cgccacacta acacttccac 3768661 agcgtgtcat tgaaggcatt ctggcccatg aggcgattca tatcaaaaaa cgtgacgttc 3768721 tgtcatcaca gcttttgcgt tttctatatc ttggagctgt cgtggggatt ttcctcttgt 3768781 ttgagcagca tatcacccat cccgaggccc acaaaattgc gctttgggct ttcattatgg 3768841 caatcattat cctattccag ctctatcaat ccttttgttc acaatggatg gaggtgcgtg 3768901 ctgacaacct tggcgcatca ttgctggacg gcggttacaa acaaatggct gaagccttga 3768961 gaatcttggc ggttcggcaa gatgaggata tacagaaaca aagtgcctat agctctgaag 3769021 caggtgaaga cgagcttcaa attgattctc tcacccgtga taaaagctgg tttttcagat 3769081 tgattgattt tcagttcgct cctcatcctc ctatgtattg gcgtgtcggc actttattgt 3769141 caaacaaagg acatggggtg ctaaagcgct ggctcagaga ccgactgaaa gaatcgatca 3769201 ctttgaaatg aaaccggtca gcgtttcatc cgtataacag atatggtgaa aaaagggagt 3769261 gacgcgaagt gattgtgatc atcttattgt ttatatctat tattgttttt ctttcagtca 3769321 ttcagccgca gccctcgaaa aacaaaagcc gccagcaggc ggacagcggg tatttcggtt 3769381 attcagatca tagctcacac catgatggat gcagcagtga cggaggtttc agcgattccg 3769441 gctgtggcgg cggagggggc ggcgattaaa cgccgccttt ttttatttca ttgattcgat 3769501 gtacgcacca aaagccgagc ctgacatgcc tggggacacg cgcacacgat ggagggcata 3769561 cattccctgg tctctcgaag ccgcgcccgg ttctgtcgtc acgcccattt gatagcctgt 3769621 tttttcagcg gccttcagcg tctcctcatt gtagcgccct accggatagc tgatgatggt 3769681 ggtttgctga tgaaacatgt tgtcgaacag ctttttcgaa tcagccatct cactttgctg 3769741 ctgttgaggc gttaatccgt tcagctcaag gtggtcaatc gtatggcttt caatcgatat 3769801 gccgtgctgt gccatttcct tcatttgttc ctctgtcaga tggtgcttat gtccgatcga 3769861 tttgccgatc ataaaaatcg ttgccttcat cccgtacttt ttcagcaccg gatacgcatc 3769921 ttgataattg tcggtgtacc cgtcatcaaa tgtgatcagc acgcacttct cactcggttt 3769981 tttatcctgc gtcagcatga gagatgcctc tttcggcgtt aatgtctgat agccgttatc 3770041 atgaagccac ttcatatgcg cctcgaattc tttctttggc acacggaggc tgtttcctga 3770101 agaaatgctg tggtacatca aaatcggcag ctttgccggt ttctctgttt tgatccatgc 3770161 ggatgtatcg tcttcttttt tctgaacttg tactgccttt ttttccggtt tcttttgttc 3770221 cgcttttggc atcggctgct ctgcattcgc ctcttgatca gcacaagccg caagagccaa 3770281 acagctgccc aaaagaaaga tgcttaaaaa caatcgtttc atcgttctcc tgctttctgt 3770341 ctatttcttc ctcctttttc atcggtttga ttctgagatt ttcaatagca aaaaaccgga 3770401 catgtctcca tgtccggttt ttttgatctt atcggattct cacttctgtc tcactgtcaa 3770461 agaaatggcc tttattcata tcaaatgcaa ccgtcagctc atcgcccgat tgaatatcga 3770521 ggcgggcgtc gatccgcgca ataaagtctt ggttgtctat ctgcgaataa atcataattt 3770581 cagaaccgag cagctctgca acattaattt tcgccttaat cgaagagttc ttatatgatt 3770641 ccacgacaat caattcatca tgtatatcct caggacggat gccgaagatg acctctttgc 3770701 cgatgtagcc tttttcacgc agcactttca tttttccttc cgggacggtt aatgccgcag 3770761 aaccgatttt gattaagcca tccgtgagct ttcctttgaa aaaattcatc gccggtgatc 3770821 cgataaaccc gccgacaaag acgttttcag ggaattcata tacatccttc ggcgtcccga 3770881 tctgctgaat tttcccatct ttcatgacta caatccgtgt cgccattgtc agcgcttctg 3770941 tctggtcatg cgtcacataa atcgttgtag tctgcaatct ctggtggagc ttaatgattt 3771001 ccgcccgcat ttgcaccctc agcttcgcgt ccaggtttga caaaggctca tccatcagga 3771061 acacctttgc atcccgcacg attgcccggc ccagcgcaac ccgctgtctc tgtccgcctg 3771121 acagcgcttt cggtttacgg tgcaaatatt cctcaagccc gagaatttta gcggcttctt 3771181 cgactctttt tttgatttca ggcttcggca ttttccgaag cttgagcccg aacgcgatat 3771241 tatcgtagac cgtcatatgc ggataaagcg cgtagttctg aaataccatc gcgatatccc 3771301 tgtcctttgg cgctacatca ttgacccgtt ttccttcaat ataaaaatca cctttcgaaa 3771361 tttcttcaag tcctgcgacc attcgcagcg tcgttgattt cccgcagccg gacgggccga 3771421 cgaatacgat aaattcctta tcggcaatat gaaggttaaa gtcatcaacc gccggttcct 3771481 tctgatcata aaatttataa atgtgctcca tccgcaattc agccatctaa catccccctt 3771541 tgttattgta aacgctttct tatattgagt gtaacagcaa ttccctctcg ctaaaatggg 3771601 cagcgttcat aaaatcaccc agccattttt cgtgcatatt tccaatttat tctgaacttt 3771661 cattttgcag gcagataaaa taggcaagaa gcgcgccttt gtacgatttg atatctatcc 3771721 ctgaccgctc aataaattta tcaatccgat attgcaggct gttgcgatgc agatgcagct 3771781 ttttcgctgt taatgtgacg tttgagttgt tttcaataaa cagcttaatg gtcttcctta 3771841 gctcagattc acttccaaat aaaagctcag cttcttcaga gagcagtgtt tccagttttt 3771901 ctttttctgt ttctaataat agaaaaggaa agatcatctc aaaggtcaca ctctgcacct 3771961 gaggcagccg tttttcagca aacaggaaat acgcctgttc acgagcgtaa tgttttcgca 3772021 gacactcatc cggctcgtaa aatcttccgg cgtaaaaacg gacactgaag tagaaatcac 3772081 tttcaagaac cttagcgagc gattccagtt cgtccttctc cgccgccgct tcactttcct 3772141 gctcgacaat cacacctctg tcctcatgga tccacacaat cacaaaagac accggccaaa 3772201 aatggcgaac cgcttccgta aaggacgtcc tttctatttt gccgaataaa tgaaagtgaa 3772261 caaatctcgt ccgtttcttt atatacgccg gcaattcccc tctggaaaaa aggaacgaaa 3772321 accacttgtt ttcctcaggt gatttcatag acagttgatt gccctcatcc gcaggcgtca 3772381 aaaatgactg cagcaccaat acttcttttt cactgatctc tgttttcgga atggagatat 3772441 atctctgatt gctctcatca aaaaaacata gacagccttc ccttatgcaa agctcctcag 3772501 acacaatcga accgggataa atagccagca gcgatttcat agagtctcct ctcttatgta 3772561 aggatctgta tattcagtat aaggcgaaac acacatgttc tccactaaaa aagagtatat 3772621 ccggtataga tagacgagaa actgaaaggg aaacctcatt cgtttacata ttggcttcag 3772681 cggaaataga agaagacatg caggaccaaa ggagggtcat cttatgagtt tcgaaacgtt 3772741 aaacaaaagt tttatcaacg gaaaatggac tgggggagaa agcggacgta cggaggacat 3772801 tttgaatccg tatgaccagt ctgtgatcac aacagcatct ttggcaacgg gcaaacagct 3772861 tgaggatgcg tttgacattg cacagaaagc ccaaaaagag tgggccaaga gcacgacgga 3772921 agaccgaaaa gccgtgctgc aaaaagcgcg cggctattta cacgaaaacc gtgatgacat 3772981 cattatgatg atcgcccgcg aaactggcgg aacgatcatt aaatcaacaa tcgagctgga 3773041 acaaacgatt gcgattttag atgaagccat gacgtatact ggtgaattag gcggcgtcaa 3773101 agaggtgcca tccgacattg aagggaaaac caataagatt taccgccttc cgctaggtgt 3773161 catttcatcg atttctccat ttaatttccc aatgaatcta tccatgagat ccattgcgcc 3773221 cgcaattgcg ctgggtaaca gcgttgttca caagcctgat atccaaactg ctatttccgg 3773281 cgggaccatc attgcgaaag cgtttgaaca cgccggtctt cctgccggtg tccttaacgt 3773341 catgctgacg gatgtaaagg aaatcgggga cggcatgctc accaatccaa tcccgagatt 3773401 aatcagcttt acagggtcaa cagcagtcgg gcgccacatc ggtgaaatcg ccggtcgcgc 3773461 cttcaaacga atggcacttg agctcggcgg caacaatcca tttgccgttc tttcagatgc 3773521 ggatgtcgat cgtgctgtgg atgccgcgat tttcggaaaa tttattcacc agggacaaat 3773581 ctgtatgatt atcaacagga tcatcgttca tcaagatgta tacgatgagt ttgtagaaaa 3773641 attcaccgcc cgtgtcaaac agcttccgta cggcgatcaa accgatccga aaaccgttgt 3773701 cggcccgctg atcaacgagc gccaaatcga gaaagcgctg gagatcattg agcaggcaaa 3773761 gacagacggc attgagcttg cggttgaagg aaaacgcgtc ggaaacgtgc tgacgccgta 3773821 cgtctttgtc ggtgcggaca acaacagcaa aattgcccaa acggagctgt ttgccccaat 3773881 cgcaaccatt attaaagctg gcagcgacca ggaagcgatt gacatggcaa atgatactga 3773941 atacggcctc agctctgcgg ttttcacttc tgatttagaa aaaggcgaaa agttcgccct 3774001 gcaaattgac agcggcatga cccatgtcaa cgaccagtcc gtcaatgatt cgccgaatat 3774061 tgcctttggc ggaaacaaag caagcggtgt cggccgtttc ggcaatccgt gggtcgtcga 3774121 ggaatttacc gtgacgaaat ggatttcgat acagaagcaa taccgcaaat atccgttcta 3774181 aatgaaaaaa tccctctgtt tcaagtacag agggattttt ctttatttag atatatccac 3774241 aaacccttcg ccaaacacat cgcgtacgtc atgtacgatc acaaacgctt ttttgtcgca 3774301 gcttctaatg atttttttca gcatagacag ctcctgtttg ttaatgacga tatacaaaat 3774361 ctcttttgac tggcccgtat aatttccctt ccctgataaa atcgtcacgc cccgatccat 3774421 caaggtattt acctgctctg caatctcact cttattttct gaaatgaccg taatggcttt 3774481 tttcgtattc aaaccttcaa taatgaagtc catcactttg gtaccgatat acagcatcac 3774541 gatcgtaaac atcatttttt ctgcaccaat aataaaataa gagctaaata ctacgattaa 3774601 atcaaaaaac aagagtgcat agctgatatt ccagtctaaa tatttattag caattctggc 3774661 cagaatcgcg gaaccggccg tcgtcccgcc gacccggata atcatgccga tcccgactcc 3774721 ggcaaataca cctgcgaaaa tcgtattaat gatcaattca tcagacggaa tgctccaccc 3774781 atgtgtcaga tgaagaaaaa gcgaatttgc cgcaaccgca atgatcgtat aaaccgttgt 3774841 ttttccatca agaaacttgt agccgattaa aagcaaaaac gcatttaaga taaagttcgt 3774901 gacaccagga gaccattgaa acagataata caaaatcagc gtaatcccag tgactccgcc 3774961 ttccccaaga tcattgggaa tcgcaaataa attaaccgca agcgcgaaga aaaaagcgcc 3775021 aatcacaagc ataagtacat ccagcattct ctttttcatc acgaaaacac tccttttcat 3775081 tgttctgttc tagcaaataa aaaaacccag gagaacgctc tcgaaaaaga gcagaaactc 3775141 ctgggctttt atcccaccgt gtcataacag ccaagctgct atgtgttttc tctcggtcac 3775201 agtccaattt gcattgcgga accctagaaa accactgttt ttatcatatc cttttcactt 3775261 tccaatatta gcattataag ggacggttcg aattggttca aggggtattt gcggagtttt 3775321 catcagataa gctggaaaaa aatacgattt atctattaaa aaagaacaga tataaccgat 3775381 aagaaaaaaa gcatatattt tacaagcgaa tgtaactata aatgataata attataagaa 3775441 attcataatt ttatattgac taagagaaat aatataggca ttatagtaca tatgtttcgt 3775501 acattttatt acataggagg aaatataatg gcaggaaaac tagtaccctg taaagcttgc 3775561 ggtcaagaaa ttgcaaaggg tgtaaaaaaa tgtcctaact gcggtaagga tcaacgtaac 3775621 ttttttatgc gacataaaat cattacgttt attctcgcag ttgttgtcat cattattatc 3775681 ggtaatatga ttggcggcgg aggcggctca gaagccactt ccaaaacatc aagcagcagc 3775741 aaagcagaaa ctgaaaaaac atacaatatc ggtgataccg taaaaactga aaaaactgaa 3775801 gtgacggtta cgaaggtaga ggacagagat actgtcggta ctcaatatgt tgaaaagaaa 3775861 gcatctgagg gaggtacaat tgtagctgtt caatatacaa ttaaaaacgt atctaaaaag 3775921 ccgattagct ctttttcaat tccaactgtt aaattagttg atgctgatgg tacttcttat 3775981 gattctgata ttgatgcttc tgtaaactat gcaactgaga caaaagttga taactctaaa 3776041 attttgagtg atctaaatcc taatattaaa gtaacaggtg taaaagcatt tgaagttgac 3776101 aaggaagctt atgcaaaagg cacttggaaa ctaaaattca gtaatgatgt tattgtgaaa 3776161 atcaaataac agctaacaag ggtgcctgtt taggcaccct tgttctttaa aaaaggcctt 3776221 ctcaattgag aaggcctcca ttcttattcc gcactcttat acccattcac attagaagac 3776281 tgccatctcc aggaatcagc acacatttcc tcaaggccgc gtttcgcttc ccagcctagt 3776341 tctcgcttgg ctttcgcagg atctgcaaag catgtggcga tgtctcccgg acggcggtcc 3776401 gcaaaacggt atggaacctc tttccctgac actttttcaa aggctttgac catttccagc 3776461 acgctgtagc ctgtgcctgt tccaaggttg tatgcatcgg ctcctgtaga gttcaatact 3776521 ttttccagcg ccttgacgtg gccttctgcg agatcaacga cgtgaatata atcgcgtacg 3776581 cctgtcccgt cttttgtcgg atagtcattt ccgaatacgc ttaattgctc gagcttcccg 3776641 actgctacct gtgccacata cggcataagg ttatttggga ttccgttcgg gtcttcaccg 3776701 atccgtccgc ttggatgcgc gccgaacggg ttaaagtaac gaagcagcgc aacgctccac 3776761 tcattgtcgg ctgtatgcaa atcacgcaat atttgttcaa gcatgagctt cgtctgccca 3776821 taaggatttg tcgcgcctaa tggaaagtct tccgtaatcg gcgatgtttc cggaacgccg 3776881 tatactgtcg cagatgaact gaatacgatt ttcttgacgc cgtatttctc catggcctcg 3776941 cataaaataa acgttcctgt caaattgtta tgataatatt tgaggggaat cgccacagat 3777001 tcgccgactg cttttaaccc tgcaaaatga atcacagctt cgatttcatt ttcagcaaaa 3777061 acggaatcta ccgcttcccg gtccaataaa tccgcttcgt agaacgttaa atcttttcct 3777121 gtaatctcct tgacacggtt cagcgcttca gctgaactgt tggacagatt atcaagaaca 3777181 acaatctcgt agccgctgtt caatagttca acacatgtgt ggctgccaat gtaaccggca 3777241 ccgccagtaa caagtattgc catgatgtaa accctcctaa aaaatgacct gttttcatta 3777301 tatagtgttt agaaccggtc cacatccatt tttaagaagt ttaatcgttt attaatagtt 3777361 ttttcatatt ttttagctta aacccttgcc agcaattcga tagaggtttc agcaagaatg 3777421 tgctctttca tttcttgata gagctcattc aagtaaaagc ccggctgaag attcagctca 3777481 gcatctaaag catagaccgt caatgtatac gcatgatcct tgtcaggcgg tgtcggcccg 3777541 caatactggt gaatcacctt tggatcgttg cttcccgcaa gcggtgaagc aaagctgttt 3777601 tgcccttgta tcatcaagtc ctgtctttcc tcactcgcat gttcaggaag ctctccgatg 3777661 taagccggaa tattagccgc tgtccagtga atccagctga atccgcatac gggaatggcg 3777721 tcatgatcga tgaaagtaag tgcgagcgtc tttgctccgg acgggatgtc atcaaaatga 3777781 attggaaagg atacaaatgg gtttccttct ctcttatatt tttcatccgc gtattttgaa 3777841 tacttgtcat gtaaatatgg atttgcttct acgtatatgt tcatatgaat ccctctctct 3777901 attttctcgt tctataggta tactaaacga atcgatgtat aatcagtgat aaacaaatac 3777961 gcatgtaaac gtaacaattt gttatggata acttgcagtg aaggagatat ttcatggatt 3778021 taaaatggct gcaaaccttt attgccgcag cggaatcaga gagcttcagg gaggcggctg 3778081 agcatctgta tctcacacag cctgccgttt ctcagcatat gaggaaattg gaagatgaac 3778141 tggacatgag gttgtttttg catagcggaa gacgagtcgt actgactgac gaaggcaggc 3778201 tctttttgcc ttatgccaaa gaaatgatcc atgtttacca agctggaaag cagaaagtca 3778261 gtcaatggaa acaggggtac agccgatcac tcacgctggc cgtacacccc tacattgcgt 3778321 cctatatctt gcctcgcttt ctgccagcct atatccaaaa acatccgcat gtcgagcttt 3778381 caactcatgt ggctggatct gacgctatta aacaagcggt ggaacacaat gaagctgata 3778441 ttggtttgtc gcggaaagac ccgaacacca acactcttta ttatcagcat atatgcgaag 3778501 gtacgctttg tctggcggct cctttccaag aaagcagacc ggatgctgca tccgtcttaa 3778561 cccgctatcg gctgctaacg catgatcatc cgtcatatgg ggatgccttt ttagataaca 3778621 tccgatcaca ttacccgtat cttcaaatga tggctgtcgg gcagacggat acggctgtcc 3778681 acatgatgaa agcgggaatg ggggcatctt tcctccctac ctacattatc aaacaggaag 3778741 aagccgaaaa aaagctgatg gctgtcagca cgcctgcaca tctagaattg cctgcgtccc 3778801 aaacgtttat gatgtggaaa agaaacagcg aagacattca gcattttcac gccatgttac 3778861 atgactttat gcagcgcgaa caagtataga gctgaaaaat caatctgccg gttgacgttt 3778921 ttctttccta ttttcgctat gcttaatgca gaaaggattt gatgacatgg cgatgagccc 3778981 ttatattttt attgtattga ttcttattat tttatcgatg tatcgagaaa gaacggtaaa 3779041 gcccgggaag ttgctgatca ttccactgtt gctcttatgg ggcgtatctg catcgtttca 3779101 gccggcgtat tttcattccg tattacatgt ggcgatcagc ggcattttat tactgatcgg 3779161 gctggcctgc gggtttggca ttgggaagat ggtaaatgta cggattcacc cggaaaccgg 3779221 aaaggtcact tcacgcggct cacttgggag tgttatcctc attctagtga tactttcttt 3779281 gcgcatggcc gcgagaacat ggctgcctga gagcaacgag atgtttattg ccattattca 3779341 ttctatgttc ttcgttcccc tcggcaccat cacagcccgc aacatcatgc tttacaaagc 3779401 atacagacga ctgaccgctg gcaaagtatc cattcaataa ccgaaagaag gaccagcatg 3779461 aacggacaaa ctccggctcg gcactactac aagaagcttg tgccgagcct tattctcatt 3779521 ttgaattgca tacaattttt atctcatcca actaaggctg atcccatttt gttagcattt 3779581 gtatttgcgg tatacttagc attcatttgg atcattccct atgtggcatc cactgctgtt 3779641 agtttgagca tattcatcgg actctggctc ctgaccgatt tcttttgggc tgtttccggc 3779701 caagagcagg gtgccgccta ttttttgatt gtatttttaa tgatatatgc cgcctttaga 3779761 ctcccttcac ggctatcctt gatcttcaca gcatgtttaa ttggaggcaa catattactc 3779821 ctatcctcac aagggggaag cttgaatacc atcatcagca acatctcgat catgctcggt 3779881 ctgtacgtcc tcttctcctc catgcgtttc agacgagaag cgagaaggga ggctgaacgg 3779941 aatcatgctg aattggcaaa aatgcatgtg cagctggagc atgctcataa agaactccag 3780001 aaagcgcatg cagagctgca ggaggcttct gttctttcat taaggtacgc ggtccttgag 3780061 gaacgtacaa gaattgcccg cgacattcat gacagcatcg gtcacgagct gacttctgtg 3780121 attgttcagc ttcaatccct tccctatatc cttaaaagca gcaaggagga ttcagaaaaa 3780181 gtcattcaaa atgtactgag tgtcgccagg gagtgtcttc aagaagtgcg gtctgttgtt 3780241 caccaaatgg gccgtagtga atcgatggtg gggcttaccg ctttgcgggg gctcattcat 3780301 caagtggagg aacggagcgg cttgcacgtt tctttagata ctgccggact gtcagaagag 3780361 tcttggcctc caaacgtgag cgaaacgatc taccgcatct tgcaggaagc gctgaccaat 3780421 atcattcgtc acgctgacgc ttctcatgcg gcggccgtca tttctaatga caagtcccat 3780481 ctctatgtca caatcaccga cgacggacaa ttcaccggca gccttactta tggatttggc 3780541 ctgacaggaa tgaaagagcg cgcagaaaaa gcaggcggtt cccttacttt cagtgccgta 3780601 cagccgagcg gcctgaaaat tgagctgtca ttgccgctca tgacaacgaa taaggagcaa 3780661 aaagatgaac aaagataaaa tacgcgtagc gcttgccgat gatcagccgc ttgtgcgtga 3780721 aggcttccgc tacgtcatca acgcacagac ggatatgacg gtttctggcg aggccggcga 3780781 cggtcacgat attatagcac tcgcaaaaca aacaaaaccc gatgtcatcc tcatggatgt 3780841 ccagatgccg cgttgctcag gcatcgaagc ggcgaaagac attatgtccg cacttccaaa 3780901 tacaaagata gtcattttaa ccacctttga cacggaagaa tacgtatttg aaggcatccg 3780961 tgcgggcgca gtcggctatc tgctgaagga tacacttcct gaggagttga tagatgcgat 3781021 tcgcgctgcg gccagaggcg aggcgatttt ccgtacagtc acagctgcta aaatcatcag 3781081 tgagacattt cgggcgaaac agcaaactca tgccgaagaa ctggcagagc cgttcaccaa 3781141 aagagagctt gaggttcttc agcaaatggc ctacggactg agaaatgagg atattgctga 3781201 aaagcttttc gtcagtgaaa gcactgtgaa aacccacgtg caccgcatcc tgcaaaaatg 3781261 caatgcccaa gaccggacac aggcagtcgt ttttgccatt cgaaacggta ttgtgcaata 3781321 gaaatctctc atcccgccat gctaaaataa gacaaaggag atgattggaa atgaaagaag 3781381 aaatcattga acggtttact acatatgtaa aagtcgatac acagtccgat gaatccgttg 3781441 acacttgtcc ttccacaccc ggccaattga cattaggaaa catgctagtt gatgaattga 3781501 agtccatcgg catgcaggat gcagccattg atgaaaacgg ctatgtcatg gcaactcttc 3781561 cctccaatac tgaaaaagac gtgccgacaa tcggctttct cgctcacgtc gacaccgcta 3781621 cagactttac cggcaaaaat gtgaatccgc aaatcatcga aagctatgat ggaaaagaca 3781681 tcgttcttaa cgaacagctg caggtcaccc tgtcacctga tcaattccct gagctgtccg 3781741 gctataaggg ccatacactc atcaccacag acggcaccac ccttctcggc gcagacaata 3781801 aggccggtat cgctgaaatc atgacagcca tggattacct catcaaacac cctgaaatca 3781861 agcacggcac aatcagagtc gcctttacgc ctgatgaaga aatcggaaga gggccgcaca 3781921 aatttgatgt gaaacggttc aatgcatcct ttgcctacac ggttgacggc gggccgctcg 3781981 gcgagcttga atatgaaagc ttcaatgccg ctgccgcaaa aattacgatt aaaggcaaca 3782041 acgtacatcc cggaacagct aaaggaaaaa tgatcaactc tgcgaaaatc gcgatgaagc 3782101 tgaacagcct gctgccggca gacgaagcgc ctgaatatac ggaaggttat gaaggcttct 3782161 accacctgct gtcgattcaa ggagacgtag aggaaacaaa gctccactac attatcagag 3782221 actttgacaa agagaatttc caaaacagaa aagaaacaat gaagcgtgcc gttgaagaac 3782281 ttcaaaacga atacgggcaa gaccggattc tgctggatat gaacgaccaa tactacaaca 3782341 tgagagagaa aattgaacct gtcatcgaaa tcgtcaacat tgccaagcaa gcgatggaaa 3782401 acctcggcat cgaaccgaag atttccccca tccgcggcgg aaccgacgga tcacagctgt 3782461 cctacatggg gcttccgacg ccaaacatct ttacaggcgg ggaaaacttc cacggcaaat 3782521 ttgaatacat ctcagttgac aacatggtca aagccgtaaa tgtcatcgtt gagattgcaa 3782581 agcagtttga agcgcaagca taacgccaaa agccagtcca aaaaaggact ggcttttttg 3782641 tgtgaaaatg aaacatttta aacacgtcct ccgtaaaaca agtatcaaca aatgaggagg 3782701 aaaaacaatg acaaaacatg caatcgctgc caagagtctc ttgaaaaaat ggatcatttc 3782761 caggccgctt aacatgaaaa agaaatccag cccatttcaa aaaatcagaa aaatgttcaa 3782821 acgcttcttc aaataaaaca tcaaatcccc taaatacaat ccgtattcac ccgtaccgcc 3782881 caaatgctcc gtaatttggg ttttttgtgt tcaattccgc aaaatagggt ataaaccaaa 3782941 caagcaagaa aacagcaccc aaaaacaggt aattcgaatt acgtaaactt aggttaaaag 3783001 ttatataaag gaatttattt tatcgtcgat agtaactata gaaccaatca tcaacaagag 3783061 caaacagcgt aattcaagac tattttcagg tcatcaggta atactgtttt agagggacag 3783121 tttcttgtta tttattgatt tagaattttt tgaatacttt ttggcatttt atccgtacaa 3783181 tagagagtac caaaactttt tttgggaggt atgtaatatg atcctattta ttatcatcgc 3783241 attatgcggc tatcttcttt tttctttcag caaggacaat cgccgcaaac cgcaaaagac 3783301 aagccctctg ccagcagccg cacctcatca caacaaccta atcgaccttg acgccatccg 3783361 ccaaaaacgc cggatgcatc tttcctaatt ctatatttca aacgaaaagg ctgctgaatc 3783421 acgcagcctt ttaaaattgt tttgatttag agcctgaaac cttttcgcca cctatccgta 3783481 atttcataca aggcaaaccc aaaggagact tcagcaatga tcgagttatt tatgaaacaa 3783541 aaaatgttct catttaaaga tgcatttcac atttatgacc gggatgaaca agaaacattc 3783601 aaggtggagg ggcgtttttt ctcgttagga gactcattac aaatgacaga ctcatctggg 3783661 aaaacgctcg tttccataga acaaaaacta atgtctttat tgccgcgcta tgagatttca 3783721 attggcggga aaacagtttg tgaggtaacg aagaaagtaa cgttttccaa accgaaattt 3783781 gtgatttccg ggcttaactg ggaaatagat ggtgatttat ggagggatga attccaactg 3783841 acggacgggg aaaatgtccg gatgtcagtg agcaaaaagt ggctcagttg gggtgattcc 3783901 tatcacttgc agattgcata cgaggaagat gttctgattt gcactgccat cgctatcgtg 3783961 cttgatatgg ttttatataa cgatgaagat gaaagtattt tctaaaaagc attgacaatt 3784021 gatccaaaag taataatatt aagataattg aaatctgaat atgaagttgt accttatcaa 3784081 gagaggtgga gggactggcc ctatgatacc cggcaaccgc tgtttcaaac agaatggtgc 3784141 taaatcctta agaacattgc gttcttgcag atgaggcgga gatttgatcg ttcaagctct 3784201 tccttacaca aaggaagagc tttttacatg cttaatattt cagaaaagag gcgaataaca 3784261 tggctcaaca aacgaatgtt gcaggacaaa aaacagaaaa acaacgcaaa gcacctttcc 3784321 gcgccgatca tgtcggcagc ttgcttcgtt ccgttccggt aaaggaagcc cggcaaaaaa 3784381 aagcggctgg tgagatgaca gcggaacagc ttcgtgatat cgaaaatcaa gagatcaccc 3784441 gcatcgtgga aaaacaaaaa gaaatcggtc tcgatgtggt aacagacggg gaattccggc 3784501 gttcctggtg gcattatgac ttcctggaag ggcttgacgg tgtggaaccg ttcatcccgg 3784561 ctgaggggat tcagttccat aacacaaaaa cgaaagcgcg cagcatcaaa gtgacgggaa 3784621 aactcgattt tacgagccac ccagcgctcg gtgattatca atttttacat gagattgccg 3784681 gtaacgcgac gccaaaattg accattccca gtccaaatat gctgtttttt ggcgaaaagg 3784741 cggataaagg gatttatgac gatcaagagg aatactttca tgatatggcc caagcgtaca 3784801 aaaaagcaat caaagccttc tatgatgctg gctgccgtta tctccagctt gatgatacgt 3784861 catggtctct cttctttgag gacaaaggca gagaggttgt ccgggcgctc ggcggtgatc 3784921 cagaaacatt gccagccata tttgccaaaa caattaacga tgccgtcgca gaccggcctg 3784981 acgatttaac gatcacaatg cacatttgcc gcggcaactt ccgctcaacc tgggcggcat 3785041 caggagggta cgacgctgta gcggaaacga ttttggacgg cttaaacctt gacggccttt 3785101 tcttggaata cgatgatgac cgctccggaa actttgatcc gctccgtttt gtgaagcgca 3785161 aggatctgca aattgtgctc ggcttgatca catcgaaata cggcgagctt gaaaatcctg 3785221 aggatgtgaa acgccgtatc aatgaagccg cgcgttttgt cagcttggac cagctatgcc 3785281 tgagcccgca gtgcggtttc gcctctacag aagaaggcaa ccttctgaca gaggagcagc 3785341 aatgggcaaa gctgcgccat gtcatcgaca ttgccaacga tgtgtggaga taatctatca 3785401 ttgacagaaa tagaaaatgt gtgaataata gatactatca gaaaatttaa taaaaaggtt 3785461 ttccttatca agagaggtgg agggactggc cctgcgatac ccggcaaccg ctgtttaaca 3785521 gaatggtgct aaatccttta gagcaatgat tgctcttgaa gataaggttg agattgtcac 3785581 gcaagctctt ccttatccaa aggaagagct tttttatatt tgaatggaaa gaaggaatgg 3785641 acaacatgtc acaacaaaca acacccgcag aacaaaaatc acttcaaaga aaaaaaccgc 3785701 cgtttcgcgc ggatcaagtc ggaagcctgc taagatctga gcccgtcaaa aaagcgcggc 3785761 tgcaaaaagc ggccggcgaa atgaccgctg agcagcttcg ccaaattgaa aacgacgaaa 3785821 tcatccgcat tgtggaaaaa cagaaggaaa ccggcctgaa cgtcgtgaca gacggtgaat 3785881 tccgcagagc atggtggcac tttgatttcc tggaaaactt agatggcgtt gagccgttta 3785941 ctcctgagca aggcattcaa ttccataacg tacagacaaa agcacgcggc attaaagtca 3786001 caggcgatat cgacttttca actcacccaa tgcttgaaga ttactcattt ctccatagca 3786061 ttgccggtga cgcgacgcca aagatgacga ttccaagtcc gaatatgctg tttttccgcg 3786121 gaaaactgga aaaggatgaa tacaaaaacg attatcaact tttccagcac gatgtatcca 3786181 aagcatataa aaaagcgatt caagcgtttt atgacagagg ctgccgctac ctccagcttg 3786241 atgatacagc gtgggccgtt ttcttatcag aaaaaggctt aaaacaaatc gaagcgttcg 3786301 gaacaacgcc tgacgagctt cgccagctgt ttgcgaaatc cattaacgac gcgattgcag 3786361 accgcccgga tgacttgacg gtaaccatgc atatttgccg cggcaacttc cagtccactt 3786421 ggacagcgga aggcggctat gacgcagcag ccgaaaccat ttttgacggc ttgaatcttg 3786481 acggactttt cttagagtat gatgattcac gctcaggcgg atttgagccg ctccgttacg 3786541 taaaacggtc tgatcttcag cttgttcttg gcttagtgac atctaaattc ggtgagcttg 3786601 aaaatccgga tgacgtgaaa cgccgtatcg aagaagcgtc ccgttatgta agcttagacc 3786661 agctttgcct cagccctcaa tgcggattcg cttcaactga ggaaggcaac aagctgactg 3786721 aagaacagca atgggcgaag ctccgccatg tggttgagat cgctaatgat gtttggaaat 3786781 aagcaaagaa aaaaacacac ttgattccct agcggagcaa gtgtgttttt tatgtcattg 3786841 tgcggtgtag cccccatcaa ggacgacagc ctgcccagtg acgcccttcg ccttctcgct 3786901 tgccaaaaac acggcataat ccgcaatttc cttgacggaa agcagtcgct tttgcggcac 3786961 aagcggaaaa atgacttgtt caagtacaga gtcgtaaggg acatttctag ttttcgatag 3787021 atcgctaagc tgattgcgta caagctgggt atcgacataa cccggacaga gcgcattgac 3787081 tgttatgccg tggggcgcgc cttccagcgc ccctactttt gtgagtccaa tgacgccgtg 3787141 cttggcgcta ttataagcgg atttccctgc aaagcccact aatccattaa cagacgcaat 3787201 attaatgatt ctgccaaact gctgtttttt catgatcgga aaaacatgct tcattgcaat 3787261 aaagggagcc gtcagcatga ccttgatcag ctgttcaaag gtgtctgtcg gaaactcttc 3787321 aatcggagcg acgtgctgaa taccggcatt gttcaccaga atatccaagc ggccgtattg 3787381 tttttggatg acgttcaccg tatcagcaac ttgcgcttcc tttgtcacat catacggaat 3787441 ggccgccgcg tcaaagcctt cttctgcaag cttggaggct gctttttcac atgcttccgg 3787501 acggaggtct gaaacgatga cgctggcacc ttcccgggcg aattctcttg cgatttcgaa 3787561 tccgattccg ccggcagccc ctgtcaccaa agcgacttgt tttctcatgt caaacacctt 3787621 cccattaaga attgagtaca gactggctta cagcgaaatc agcttctgtt ttttcataaa 3787681 cctcttcaat tgtgacacca tcctgaagct ccgtcagtgt catgcggccg ttcacaaaat 3787741 caaatacagc caaatccgta atcagcctgt gtacgacttt ctggcctgtc agcggaaggg 3787801 agcatgtttt tttcaccttt gattcaccat gcttattgac gtgctccatg atgacaacga 3787861 ttcgtttcgc cccgttgacg agatccatgg cgccgcccat cccttttacc attttgcccg 3787921 ggatcatcca attggccaaa tccccctgct ccgaaacctc cattccgccg agaatagcta 3787981 aatcgatatg cccgcctctt atcatcgcga atgactcagc gctgtcaaaa taagaggcgc 3788041 ctgtcacttc agtgatcgtt tcctttcccg cattgatcaa atccgcgtct tccgttcctt 3788101 ccagaggata ggggccaatt ccgagcaagc cgttttccga ctgaagcatg acgtgaacgc 3788161 catcgggtat ctcatttgcg acaagcgtcg gcattccaat cccgagattc acattcatgc 3788221 cgtccttgat ttcttgtaca gcccgtttga ccattcgttt tctcgcttcc ttcacttggc 3788281 ctcacccttt cccgatgctt gctgaactgt tcgtttttca atccgttttt cttggctcgc 3788341 gccaagcacg acatgctgta cgtaaattcc cggcgtatgg atgtgatctg gatcgagctc 3788401 tcctgcttcc acgatttctt ccgcctcggc aatcgtgatc ttgcctgcca tggcggcaat 3788461 gggattgaaa tttctcgccg ttttcctaaa aatcaaattg cccatggtgt ccgctttcca 3788521 cgctttgacg atcgccacat cgccggtaat gcctcgctcc agcacataag tccggccgcc 3788581 gaatgtttta tgttcttttc cctcggctat ggaggtgccg acgcctgtcg ccgtataaaa 3788641 tcccggtatg cctgcaccgc ctgcacgaat tctctcagcg agcgttcctt ggggaacaag 3788701 ctctacctca agctctccgc ttaaaaactg ccgctcaaaa attttatttt caccgacata 3788761 ggaagcgatc attttcttga tttgcttgtt agccagaagc aaaccaagcc cccagtcatc 3788821 gactccgcag ttattgctga caacggttaa atcctttact ccctgatctc ttatagacaa 3788881 aatgagctgt tcagggatgc cgcacagccc aaaccctccc gcgatcagcg tatccccatc 3788941 atgaatcagt ttcgcagctt ccttgcttga tgacagcact tttcccatat tgatgcccct 3789001 ttcgttttct tctacactag accagtcagg ctgtaaatcg cgatcacagc aaatacggca 3789061 gccgttttaa tgagcgtgat cgcaaaaata tcgcgatagg attgccggtg ggtcaaaccc 3789121 gtcacggcca gaagcgtgat aacggcgcca ttatgcggca gtgtatccat cccgcctgat 3789181 gccattgaaa tgacccgatg catcacctct ggcggaatat tgtaagcctg aatcgcctgt 3789241 aagtattgtt ctgacatcgc gcttaacgca atgcccattc ctcccgaagc cgagccggtg 3789301 attcccgcca gcgcagttgt cgtaacggcg ccatttacaa gcggatcggt aaaagtatgt 3789361 gaaattccgc tgctcagctt atgaaacccc ggcagcgcgg cgataatgcc gccgaacccg 3789421 tactcagcac ccgtattcat agatgccagc aaggcgccgc caattccttc attcagccct 3789481 tccttcaatt gggcaaacac acttctccaa tcaaataata tcgttgtgat gatgccaatc 3789541 actaaagcaa tctccaccga ccaaatagca gccgctgaag aaatatcaag cctgccgaac 3789601 tcctttaatc ctatggaaga aaaatcaaat ccattcggat accactttgg caggtaaatg 3789661 gtgaaatatt tattcactgc accgacgaga ataagcggga caaaggcaag cgcgtgccga 3789721 atcgggcttt tgtccggttc agccgcggac tcaatcgatt caggagcagg agcattctgc 3789781 gaatcaaaac cgccatagcc ttcgccagat gcctgcgctt tcttccgcct tgattccaaa 3789841 tagagcatcc cagctgccag cacaatcact gcgcccatca aacccagcca aggggcggca 3789901 taaatgtctg ttttgaaaaa cgacgtcggg atgacatttt ggatttgcgg cgttcccgga 3789961 agtgcgtcca tcgtaaacgt aaaagctcct aaagcaatcg tacccgggat gaggcgtttt 3790021 ggtatgtttg cttcttggaa catgtttttc gcaaaaggat atacagcaaa tacgacaaca 3790081 aacaggctga caccgctgta cgtcaagaca gcacccatca gcacaatggc aagtatcgct 3790141 ctttttgccc cgacaagccg gacaattgtt ttcgcgattg atgccgcaag cccggccatt 3790201 tcaacgacct ttccaaaaat agcaccgagc aaaaacactg ggaaatacag cttaataaaa 3790261 cccgccatct tctccataaa aattgatgaa aaaaaaggaa gcacatggct tggatctgtc 3790321 agcagcaccg cgaataacgc gcaaatcggc gcaaacaata tgacagaaaa tccccgatac 3790381 gccgtaaaca tcagcaaacc taacgccaat agaatgatga tcagttccac acacacatcc 3790441 cccgtttccg cgaactagaa agcgtttaca aaaacctgtc cgcatcggct gtttccgtcc 3790501 cctttccata tgtacgagaa gcgtgggcca actattccga ttaaaaaagg aaagctcctt 3790561 ttttcggagc tttcctctac cattcatttc attcctatta ggatatcaac atcaaccgta 3790621 atatcggctg atttcatctc tttcagcagg ctgactcgat ctttcggcgc cgaccaggca 3790681 agcggcgtca tcttgagaag ccagtggatc gcctgctggt caagcgtttt aacatagcgc 3790741 agcctgacag gacggctgtg tgctgcattt gctgtaaaac gctcaactgc tgccgtattg 3790801 gaatacgtgc gccttggtga atcagtatat aaaaattgcc ttaattctat taaatagtcg 3790861 cttcgcggca ctacttttat gagcatgcca tcattcttca gcagtctatg aaactctgca 3790921 taattggacg gcgaaaaaat agacagaaca acatcaaatt ggcgatcatg aaaaggagca 3790981 cgcgccacat cggcaaccgc ccacatcaga tctttgaatg ccttagaagc ttttaagatc 3791041 ccgtccttcg aaagatctat gccggttcct atcgctgctt tccctgcata atcaaacccg 3791101 caaagcgcat tcaaatgaga accctcaccg caaccgctgt ccaagatggt gaatgcctca 3791161 tgaccagatt tgggatgact gatgagctct gcaatcgcat catggagcgg gtcaaaaaaa 3791221 ccacattctc caatcagcct gctcctcgct tcaaaaagct cggcaccgta actggttttg 3791281 accggcttcg tcagaaagtt cacgtagccg tgccgagata gatcaaatgt atgtcctcgt 3791341 tctgtacaaa tcaagctttt ccctgatgcc gcatccatag aagaatcgca gagcgggcat 3791401 cgaaacatgc tgaaatcaac tgttcgcttc atgataaaaa acaccccatt cattcatttt 3791461 tagataaatg aaaaaggcat agacaaataa acctaggcct atctcaaaaa ttggccaggt 3791521 ctggcagttt gtctacacct gtcattatct ataacgaatg aattggataa tcatgaaaaa 3791581 aactcccttt ctgctgtatg ggtttccccg tttccatcat acaacaaata tccaggagct 3791641 ggaaccttat agtgaagaaa aatcagtact gacatgctgg tatcccgcca acatcatatc 3791701 agcatagcaa tccagcatgt ttttccttta ttttctcatt ttagaatata aattttatta 3791761 ttgtgaaaat agttaaaaag gttgattttc aaaaagtgaa aggataaaat actgctatca 3791821 tcttagaaaa agacattctt gtatatgatc agtaatatgg tctgattgtt tctacctagt 3791881 aaccgtaaaa aactagacta caagaaagtt tgaataaatt tgaacgagtt gaaaaggaca 3791941 agttcttttc tgtttgctct tatttttcac actttctgca cttccagaat ttgtgaagga 3792001 taagagcttt ttttgtttcc ataataaccc tcataggagt tgctatcatg tactttttac 3792061 taaaccttgt cggtctcatt gtgattatgg cagttgtatt cctatgttct ccgcagaaaa 3792121 agaaaatcaa gtggcgcccg atcattacgt taattgttct ggaattgctg attacttggt 3792181 ttatgctggg aacaaaagtc ggaagctggg ccatcggtaa aatcggtgat ttcttcactt 3792241 ggctgattgc ttgcgccagt gacggtatcg cgtttgcctt tccgtcagtg atggcgaatg 3792301 aaacagtaga ctttttcttt agtgcgcttc ttccaattat ctttatcgtc acattctttg 3792361 atattttaac gtatttcggc attttgcctt ggctgattga taaaatcgga tgggtgattt 3792421 caaaggcttc ccgcttgccg aaattagaaa gctttttctc tattcaaatg atgttccttg 3792481 gaaataccga agcacttgcg gtcatccgcc agcagcttac ggttttaagc aacaaccgcc 3792541 tgctcacatt cggtttaatg agcatgagca gcatcagcgg ctccattatc ggatcttatc 3792601 tttcaatggt gcctgcgaca tacgtgttta cagccattcc tttgaactgc ttaaacgcgc 3792661 tgattatcgc aaacctgctg aatcctgttc acgtgccgga ggatgaagat atcatctata 3792721 caccgcctaa agaagagaag aaagactttt tctctacgat ttctaacagt atgcttgtcg 3792781 gcatgaacat ggttatcgtt attttggcaa tggtgatcgg atatgtcgca ttaacgtcag 3792841 cagttaatgg cattcttggc gttttcgtac atggcctgac catccagaca atttttgctt 3792901 atctgttcag tccgttcgca ttcctgcttg gactgccagt gcacgatgcg atgtatgttg 3792961 ctcagctgat gggcatgaaa ttagcaacga acgagtttgt tgcgatgctt gacttgaaaa 3793021 acaatctcaa atcccttccg cctcacaccg ttgcggtggc gacgacattc ctgacgtcct 3793081 ttgcaaactt cagtactgtc ggcatgattt acggcacgta caattcgatc cttgacggag 3793141 aaaagtcaac ggtcatcggg agaaacgtgt ggaaactgct cgtcagcgga attgcggtat 3793201 ctttattaag tgctgcgatt gtcggcctgt ttgtgtggta gaaacattga gccatatccc 3793261 ttttcggata tggctctttt cattattgat aaatagaggc tggcacctgc acatcccgga 3793321 ttcccgctgc ataaggcccc aagtcatact ggccgaagac gatggcgatc ccgtttgccg 3793381 taaagtaaaa cattgtgtct ctgtttaggg ttatatcctc tttctttaca tcagagaaaa 3793441 acagcacatc gtgttttttg atatagctat ataggtaatc tctcgttttg ctgacttttg 3793501 ttttggtgtt cagaatctga tccagcgtca cccgcttttg tgctttcaag tcatagttga 3793561 aggactggac agacgttaga ccgtgggcgc cccctgaata gatataattg agtgtttgaa 3793621 tgctgagctt gcctgccgca ttgtatttga cgctgaagga tgtttgatat tcccgtttta 3793681 aagccctgct gttcgcctgc ttttttgttt ttcaggtatt cctgatacga ttgttcatgt 3793741 aggctttcag ctcttgattg attttctttt caaacgcggc attcccgacg tgatgcactt 3793801 gtggatacgt taactccttg atctttttgt acgtatgggt gctgacagtc ggtgttttcg 3793861 cttgaactgc ttttaaagat ggggccgcat atgcaaatac agaaaaaagc aagactgcaa 3793921 tgcccgcggc tttcagcatg ttattccatt tcatacaatc tactcctttg atgtcgttgt 3793981 ttatcattcc cttatttaag caatacacac ttttatagac tgattaaatc gaaagaagtt 3794041 tctaggtcta acagcatgat ttttccaata aaaaaagaga cacaggatgt ctcttttttt 3794101 actgtttgcg cccagaaatc gcttcatgaa gggcttgtgc caaatctgta tttccgaaca 3794161 tctctaatac cgcaatgaca gtctggtccg gaatgtgctc tgcttcgtgt tttggcacga 3794221 ccagatcgtc catggttttt ttcaagcttt cattcagctt ttgctgcgga tacgctttgg 3794281 cgtacagctc catcggatca agatcatggt tcacgcacca ctgggcaaac accaaaatca 3794341 tcatattttc atcgcgttcg taagcttcag tgagctgttt ttcgttcatt tgtcatgctc 3794401 cttatgaaaa gtatcttcct taaagataca ggagccgatc aaattcgtct atcccaatgg 3794461 cgatgagcag caaccgcatc gataaatgcc ttgctgaaag cggtgtagtc aggttcatct 3794521 ttagccgtta cgatgcctag cccctctgtt gtcccgacag aggattgaag aaggtcaatt 3794581 ccttcatttg ccgcaccgat cgccttgtag tgattgtaag cttctctgat aaacgccatc 3794641 gcttgtttgt tgtcttttaa ctccagtcct cctgcggcat agacggcatc atacagaaca 3794701 gaatcaaccg tcaggaacgt gccgctggcc tcaagctgct gtccgctgcc gcttgtcata 3794761 taccccagat tttgactgat gatatccact gtgattcctt cttgctttaa ggcttccagt 3794821 actgtttgca gctctttttc atgaaatccg tttccggcga gtacagcgac ttttcttgtt 3794881 gacgcggttt tcactgtacg ggcttggctt aacgcaggcg aagtaagaat ttctttagat 3794941 gctttacgct tcgcgggcgc cgccacgcct actcctttgg cgatttcttc tgctaaatct 3795001 gcatcgacat tgctgaagac atcaacgacc tgccgctgta cgtctttgct tttgaccttc 3795061 ccgacctcga agcagaaagc agaaatgatg tgctgtttct ccacaggaga catgctgttc 3795121 cagaaaagct tcgcctgtga gtaataatcg ttgaagctgt cgcttcgctg gcggattttt 3795181 ttgccctcga ctttttcctg atagtggacg tagccgcctt cttcagctgt cgcaggcgac 3795241 ggatcattgt tttgcagtga gtttttatga taagcgacag gtcccttatt gatcgtcatc 3795301 cggtgatagc cgtcgtattg gttgttatgg aatggacaga ccggccggtt aatcggaatc 3795361 tcatggaagt tcgggccgcc aagacggatg agctgtgtat ccgtataaga gaaaagccgc 3795421 ccctgcaata gcgggtcatt ggtaaaatcg atgcccggca cgacatttcc cgggtggaat 3795481 gcgacttgtt ctgtttccgc aaacacatta tcctgattgc ggttcagcgt catttttcca 3795541 atgatcttca ccggcacaag ctcttccggc cacagcttag ttgggtcaag aatatcaaaa 3795601 tcaaacttga attcatcttc ctcatcaatc atctgcacgc cgagctcgta ttcaaccttg 3795661 ccgccgtttt caattgtttc ccacaggtca cggcggtgga aatctggatc tttcccggca 3795721 attttttgcg cttcatccca tacgagagaa tgcacgccga gcaccggctt ccagtgaaat 3795781 ttcacgaaac gtgcctttcc ttgttcattg acaaaacgga acgtgtgaac gccgaagcct 3795841 tccatcattc tgtagctgcg cgggatgcct ctgtcagaca tcgtccacat caccatgtgg 3795901 gcagactcag ggttattggc gacaaaatcc caaaatgtat cgtgagcagt cgcagcctga 3795961 ggcatttcat tgtgtggctc aggcttaaac gcgtgaacca aatccggaaa tttgattgcg 3796021 tcctgaatga aaaacaccgg aatgttattt cccacaaggt catagtttcc ttcttcagta 3796081 taaaattttg tcgcaaagcc tctggcatcc cgcaccgtgt ctgcggagcc tttagaaccc 3796141 gcaaccgtag aaaaacggac aaataccggt gtcttcaccg aagggtcctg aagaaatttg 3796201 gcccgtgtgt attccgtcat tggttcgtaa acctgaaaaa agccatgcac gccaaatccg 3796261 cgcgcatgca caacgcgctc cggaatcctc tcatggtcaa agtgcgtcat tttctcccgg 3796321 aaatgaaaat cctccatcag cgtcgggccg cgaaccccgg cttttaacga gtgctcatcc 3796381 tctgacactc gcaagccttg gtttgtcgtc attttcttcc cgctgttatc ggtcctgtac 3796441 tgctcaagct gctcgtcctt tgagtgttca tttacacgtt tgttttggtc atcactcatg 3796501 tctgctcccc ctttttaaaa cgaaacattc tacagcacat ttacccgtgg cgttcttcat 3796561 ataaactgct aatccgctca ttaggatttt tggtctacat ataaatatgc ggtcatacac 3796621 atttgaaata agccttcttc acagaaagaa aggatggaag cgcttaccaa aaaagctgtt 3796681 gaatagggga ggtcatatca tgcttgccat actcggtttt gtgatgatga ttgtctttat 3796741 gtaccttatt atgtctaacc ggctttccgc tcttattgct ttgattgtcg ttcctattgt 3796801 gtttgccctg atcagcggat ttggcaaaga tctcggcgag atgatgattc agggcgttac 3796861 agacctcgcc cctaccggta tcatgctgtt attcgccatc ctgtatttcg gcattatgat 3796921 tgactcaggc ctgtttgatc ctctcattgc caaaatctta tcgtttgtca aaggagatcc 3796981 gttaaaaatc gccgtaggca cagcggttct gaccatgacc atttcgctgg acggagatgg 3797041 gacaacaacc tatatgatta ccattgcagc gatgctgcct ctctacaaac ggctcggcat 3797101 gaaccgtttg gtgttagcgg gaatagcgat gcttggttcg ggggttatga atattatccc 3797161 gtggggcggg ccgactgcga gggttttggc ttccttaaaa ttggacacgt cagaggtctt 3797221 tacaccgctg attcccgcta tgatcgccgg cattctctgg gtgatcgccg ttgcttatat 3797281 cctcggaaag aaagagcgga agcggctcgg cgtcatttcg attgatcacg caccgtcttc 3797341 cgacccggag gccgcaccgc tcaagcgtcc cgctcttcaa tggtttaacc tgctgctgac 3797401 tgtcgctctg atggccgcac tgatcaccag cctgctgccg ctccctgttc tttttatgac 3797461 tgcgttcgcc gttgccttga tggttaacta tccaaatgtc aaagagcagc agaaacgaat 3797521 ctcggcgcat gcgggtaatg cgttaaacgt tgtctcaatg gtgtttgctg cgggcatatt 3797581 cacaggcatt ctctccggca caaaaatggt ggatgccatg gcgcattctc tcgtttcact 3797641 catccctgat gccatgggcc cgcacctgcc gttgatcact gcgatcgtca gcatgccctt 3797701 cacctttttc atgtcgaatg acgcctttta cttcggtgtc cttcccatca tcgccgaagc 3797761 cgcttccgct tacggaatag acgccgctga aatcgggagg gcctccttgc tggggcagcc 3797821 tgtgcatctg ctcagcccgc ttgtgccttc cacctatcta ttggtaggaa tggcaggcgt 3797881 cagctttggc gaccatcaaa aattcactat taaatgggcc gtgggaacaa cgattgtgat 3797941 gaccattgcg gcgcttttga ttgggattat ttctttctaa atgtatgagc ttgatcgtag 3798001 cattgagtga gtacgtgatt tacagagggg agaagatcaa ataggatatt atgagtgaat 3798061 agaagattca tgccaacaac ttctcattac aatcataaga gcctgctata ttgcagcagg 3798121 ctctttcaca tttggcatta tttttttgta tagcgcaccc agtcataatg agcgtatagc 3798181 ggatttacac cattgtagga gccaagccat tcatcgacac ccgtgccatt ccacaagttc 3798241 atcatgatct ttccaggtgt tgtcggaatt tggtttgttg cagtatgttt taattgcccg 3798301 tcgacatacc atttaataga gtttggctgc caatcgaatg catacgtatg ataggcattg 3798361 gctgcatcaa acccgagatc aacaatcttc tcatggtttc ctgcaccatt tgtataatag 3798421 ttaaattgaa ccttcgttgt gtcttttcct aaaaattcga tatcaatctc atcccaagga 3798481 gttccatctg ttggacctgt gtaagtgaag aacgatgaaa cgatccctgt gtttttagct 3798541 ggtttcattc tgacttcata aagtccatag ccatatgttt gaacagaacg gttttccccg 3798601 cagtcaaact tgttataagc tgggcttgtt agcgctaaac gcatttcacc caatgacgtc 3798661 attgatacgt tattagcccg ccacgtgcag ttgaacatat ttccattcga ataaccatct 3798721 gctttttgcc aaaaaccgga gttatagccg ttaaaagggt caaaaaacga tccacctgtt 3798781 tgagctgagg cagtagcagt gactgcaaac aaactcataa acaatccagt gacaagaagc 3798841 agcaacactc gtttcagata aggcatattg gcattcccct ttcattgaaa gcgttttcta 3798901 tgttgatctt acatgattct tttaaaaggg aacatcggtc aaaataatga taatatcgaa 3798961 tcttactaac ttgaatcctg taactatcat catcttccct ctgaaaaaaa taaaaaccta 3799021 aattaccatc agcacagaca gagatgatcc gcactcattg caatttaggt tttgcctgct 3799081 ttatcagtaa caatcctacc attttcatat gtgaatgtaa gaaaaagtga acacaaggaa 3799141 acacaaatgt cagcgctctc attatgcttg tttaactacc ctttctatgt gaatggttaa 3799201 atacagcagc tcgtcacttg tgagcttgtg ctcatactcc cgctcaatgt aggtttggat 3799261 tttcttcgtg cattcatacg cgcgatgata cttttctttc actgtatcca gcaaaaaatc 3799321 gtcctggctt tccatgtgag tgccgttaaa tagacgctgc gcgaaaaact ttaagtgggt 3799381 gacgaaccga taatagtgaa gcgattcttc gttgaattca atcttaaaat ggtattttac 3799441 aatactcaaa atctcttgca tgacttttgt aatgttgata atattgggca tctcttcatt 3799501 cagctcggca tttacaatat gcagagcaat aaagcctgct tcatcctctg gcagagacac 3799561 accagtcttg ttttttacca taaccaacgc ttctttgccg atcgcaaatt cgtctttgta 3799621 gagccgtttt gtttcccaca gcaaggcgtt tttgatatca agccctttct ggttgcgctg 3799681 gatggcaaag ttaatatggt cggtcagcga cacatagatg ctgtcgttga gctttttgcc 3799741 gagctgtaat tttgcgtagc tgataatctc ttcggatact tccatacact cgatcggtat 3799801 atcatacaaa agggttttga acttttctga tacatccttg ttatcgagcg tgaacacttt 3799861 ctcaatgcgg gcttcatcga catcatcgcc ggactttttc tgaaacgcga gccccctgcc 3799921 catgacgacc aattctttcc cctgttcatt gaccacgctg atcacattat tgttgatcac 3799981 cttcgcaatt ttcatggcat gtccctccaa atctactaag aacagactat atcttgattg 3800041 tacattcttt ttgtactagg tcaatatcat cagggaaaga cggaagctgg tcagtacaat 3800101 tcactccgta cctgctgccc gggctgtttt tgaagcagcg cctccagatg gcgttcaaat 3800161 gatgccttgt cagctttctg ctttttgaca atgctgttca tgattttaat gctttcagca 3800221 ctgtattgtg tatattgttt tttcagctga tccagctgct gtcttgtctt cttcgcgttt 3800281 ttcggtgtga cttggttgat gagtttgatc atactgtctg cggtctcaaa aaaaccggct 3800341 ctattttctg tcagctgctg aatttcgatg cggctcatat cttgattacg cgttttttga 3800401 agcaaggcaa ccgcctcgct gttttgtttt ttgagcgatt tgttctcaag cttaatcgat 3800461 tcgagattct ccttcgcaat gtctgcttct tcttcagtca tgctgattcg cacgaagtat 3800521 tctggattgc cgattccata atcaaatgct tcgctcactt gtatcatgga actgaacaca 3800581 atggccagct gcctgtcgct tgcgagggct tggaaatcct gctttttctt actgctcatc 3800641 ggtttggctg cggtttgttt tactgtcttt tgatcacagt ctgcgaacat ctgagcctca 3800701 ccttcacttt cgcatgcgct catcacaaga actgtgacca gcaggcttat acacaagcct 3800761 attcgcctca tgctctgtct cctctctgct gaatcccttc tggaaaatac cataaaatat 3800821 agttaaatgg taccagatgc acctaacccc agcaataaat caaaagtatg atttgaagcg 3800881 aaaaaacata aatattttgt aaaaattgac gtgcattcca ttcttttcag gcccatttct 3800941 cgtacaatag aagtatcgtt accggagagg ggctctgatg atgaaacgtt ttacgaaaca 3801001 agaaaacagc tgggtgttat atgactgggc aaattcagct tactcaattg tcgtgaccac 3801061 cgcggtattt ccgttatttt ataaatcagc agctgcggaa agcggtgtca gcgccgctca 3801121 atcgactgcc tatctgggct ataccattgc gatttcaacg tttattcttg cgatgctcgg 3801181 ccctatttta ggcacaatcg ccgactatga agggtgcaag aaaaagttct tcggtttctt 3801241 tgtgtcagcc ggtgtcgcca gcaccgcgat gctcgccttt atccctagtg aacattggct 3801301 gctattgttg ctgttttata cggtatcggc tatcggtttt tccggcgcca atgtgtttta 3801361 tgatgccttt ctcgtggacg tcacgcctga gaagcggatg aatctcgtct cggcacgggg 3801421 ttttggctta ggatacattg gaagcacgat tccatttatc atcagtattg ctgtcatcct 3801481 gctcgcacaa gcagagacta ttccagtgtc tgtatcggcc gcaagccagc tgtccttctt 3801541 cataacggct gcctggtggg ggctgttcac catcccaatg attaaacatg tccatcaacg 3801601 ctattacatc aaaaaagaac ctcatattgt catcaacagc tttaagcggc tcggccaaac 3801661 gatgaaacgg atcaggcaat accgggcact tttcctcttc ttgctcgctt atttctttta 3801721 tatcgacgga gtcggcacga ttattacgat gtcgacatcc tatggatcag atttagggat 3801781 cggctcctca agccttctga tcatcctatt tgtcacccag gtagtcgccg cgccgttttc 3801841 gattatatac ggaaaactgg cagaacgctt cacggggaag accatgctgt acgtcgggat 3801901 cgtcatttat atgatcgtct gcgtgtatgc ctattttatg gagacaacgc ttgatttctg 3801961 gatactggct atgcttgtcg ccacctcgca aggcggtatt caagccctaa gccgttccta 3802021 tttcgccaag cttgtgccaa agcgccacgc caatgaattc tttggcttct acaacatttt 3802081 tggaaaattc gcctcaatta tggggccgct gctcattgcc gttaccgccc agctgaccgg 3802141 taaatcctcg actgcggtgt tcagcctgat cattttgttt gtgattggta ttgtgattct 3802201 tgcctttgtt cccgaggaaa ccagcacaga tgtcagccag cagcaaaatg acctgcccct 3802261 ttaactggga gcaggtcatt catcatttat tcgctttatt caccttcagc tgtttccctt 3802321 tgacggttgt gttcttcatc actttgagaa catgagggcc tttaccattt aaaatctcaa 3802381 cgtatgaggc gttatccatg atcgtgatga tgccgatgtc gtcagctgac acaccgtcaa 3802441 ttttggcaat cgttcctaca aaatcaacgg ctctgatttt ctttttcttt ccgccgttaa 3802501 aatacagctt cataatgtct ttattcagct cttcgctttt gtcctttttg ctttccggac 3802561 ggtcattcag tttagctaga aattctggtt tcttccttgc cacttcctct tgagaaggtg 3802621 cttctatttt ttggatttca aatccgatat attcttcaat gtcggctaaa aaccgttttt 3802681 cgaaggccgt gacaaacgaa atggcctttc ctttgttccc tgcgcgtccc gttcggcccg 3802741 tgcggtggac atagctttct ttttcaagcg gcagatcata gttgatgaca agggagatat 3802801 tttcaatatc aatcccgcgc gcggcgacat ccgtcgccac taagtaacgg tactcgccac 3802861 gtttaaattc attcatgacg tcgaatcggt cttcctgaat cattccgccg tgaattttat 3802921 cgcatggata tcccaagtca tccaattcat cggtcagctg attgacgtgc tccttcgttc 3802981 ggcagaaaat gatgcagctg tcgggattct ccgtcatcag cacatctttc agcaatgaaa 3803041 acttattctc ttctcttact tgaatcaccg catgttcaat atttcttgtg gttaggccgg 3803101 ccgctttgac ctcgatatgc tcggggtttt gcatatattg acggctcagc ttctcgatat 3803161 cctgcggaag cgtcgctgaa aacagcatcg tcgtacgctc agtcggcaga tgcttgataa 3803221 tcgcctccac ctgctcaatg aagcccatat tcagcatctc atccgcttca tcaatgacca 3803281 aataagagag acgatccaac ggcagcgtgc ctttttcgat atgatccaga acacgtcccg 3803341 gcgtgccgac aacaatgtgg cttttttgct taagctcagc tttttgttta tcaaaggagg 3803401 attttccaaa tacggctgtc gctttgatcc gtttaaatcg tccgatgttc gtgatatctt 3803461 cctttacttg caccgcaagc tcacgggtcg gtgttaaaat aagcgcctgc ggcttgtttt 3803521 catcccaatt cgccagctca cagagaggaa tcccgaacga agccgttttc ccgcttcctg 3803581 tctgtgattt gacgacaaga tcctttcgtt caagggcagc ggggatcaca ctctgctgca 3803641 ccttggtcgg ttctgtatat cccagtcctt ccaatgctcg taaaatgtca tgactgattt 3803701 gatagttttt aaaatgactc atgtataaac tcctgtctct tgcagatgtt ctcattatac 3803761 tctaattgac caaggcatat gtgttttgtc gaaaaatgat gtattaaaag ccagcgattc 3803821 cctggcgttt tagctcctga acagccaatc gcgccagtgc gtcggccccc gcgcgattcg 3803881 ggtgcagcgt atctccatcc atataaagcc cgagtgttct ttccggaccg atcgatgtaa 3803941 agtatgccga gctgaggaca tttaagtcaa tgagatatgt tttttcctct tcggccaaag 3804001 ctaaaataga ggccctgtac catctgttta cagacgaatg gatgccttca gaagtaaaat 3804061 cggttgcccg gccctgaggc gttgatagga tgacgtccgc tcctttcgct tttacctgac 3804121 gaatcatatc acgcatcacc tctttaaact ccgcttcaga ttctttatgc ttcggatttg 3804181 tgtcattaat gccaagctgc aacataaaat aatctccggg tttaatatac ttcagaatcg 3804241 cctcaagctg tccatcattt ctgaaccctc tcgcgatctg cccgccagac gccatgtttc 3804301 tcacttgaaa ggtgtgttta tcgatatagt gaggcagcat ctgcccccag cccgcctgct 3804361 tgctgctgtt gagcggataa taattgcaca ccgtcgagtc gccgccgaca taaatggttc 3804421 gattcgttac cggctgatca gacaatttct ttattttcaa ggcgctgagc gtaaaagcgg 3804481 tgcctgcctt tccctctgtc accagcagat tcagctgccc gtcggtgacg ggaatttgga 3804541 acgtatcctc cgcgccatcc cctgtcatat tgatgacctg aaacacgccc tccgctgcca 3804601 cactggccct tgccgtattg ccaagcgtca ccttcacctc ataaaggcca ttcgggagat 3804661 caacattaaa cgtgttattg cttttcgtcc catacgctaa aaactgaacc gcatcactct 3804721 tcacaccagc cccggatgcc gccacatccc tcatattctc cggtgtttga aaaccgtagc 3804781 cctttgaccg gtcataccga tcagacgccc tgacaccaat ataaccaggc tccatcgaac 3804841 cgcttccaaa gtcaaactga tacaccttcg gctccgccgc cttcacattc tcaatcccgc 3804901 caaaacacag catcagcatc atcacaaaaa ccgctgccat ccattttttc atcaagactc 3804961 cccctctatg aaaacgaata cattaatgca tactcggtga ttgtttcttt atgatgactg 3805021 aattaagaaa aaaattgcgt tgaggaataa aaatgagggg agagtctcaa gaaggggaaa 3805081 atcagtgtga cttcttgtca cacttgatca catcccaacc tccgcaatag aagcttattt 3805141 ggttttcttc gtcatacaca taataacgga gtctttccca ttgatcgtca gtcggtacaa 3805201 tctccaatgc aaccgaatcg atggattcaa ggtcatccag ctttgatgca ctaatgtttt 3805261 caaaccgcaa ttgaatgtca caggtttgag cagatcgttt tcattcaaac acaggaatat 3805321 gaatataacg atcatcttct ttcatataga aagaaaactc gtttaatgta aatggacctg 3805381 tatcctcatc agaaagatgc tgtttcaatt tctcgtattg tgtgatattc aaatgaattc 3805441 cctctattta tatgattcac cgccaatcat ataaatgtcc acagcatcgt attcaaacca 3805501 tatgatccgt tcgcctgagt ccgttaggca ttggagcttc ccttctgaaa aatagctttt 3805561 atccggttga ggatcagtga tcagaaaaac atcatcattg atggaagcta gcagaaagag 3805621 aaaatctgca atatcccggt ctgcttcctg taatatggat tggaaatgga attccctttt 3805681 ggccagcttc gtcaccttgt aagcatgacc ttcaaaatac tcggacaggt cttctataaa 3805741 tgaaccagtc gttattacct gtatcatgat tcgatcgtag gcaagccctg cccaaaaacg 3805801 ataaaacgac tctgcatctt caagttcgca tgccataacg gtttggtcag gcttaagctc 3805861 gatcatgtcc aaattgccaa tactgcttat agaggttatt tccataaaat cttcccctta 3805921 tcagttggat agcgcaacgc aaatctcttg tctgacttgt tcatacaaga gaatgtgatg 3805981 atacagatcc ttatcgtttt tgatcatatc cggaagtatg tcaggataca gctcaaaaaa 3806041 gcttttctcc aacgaacgcc gctgatgccg gggtatcctt ttattcgcca gcacataatc 3806101 caaactgcca gcaacaagca taaaaaactc atagatttcc gcttcaaagc cgtacaattc 3806161 atcagggtac tgcttttctt caagctctcg ctgtcttttt ctcagttttt gaagcacgtt 3806221 gatcctctcc cttccgcaat aatctcattt atttcgaaac agaataggcg gatcattatc 3806281 tatcgcctcc aacagctctt caccaaacac agtgattgca catttccacg ggtctcccaa 3806341 aagtccccag gagaagtcct gatgaaaaaa gaaataatag tctccatttg gaaatacggg 3806401 aacaggccat tcgccaaatt catccttagg cattgcctga tgaggactaa aggtatatcc 3806461 gtcatgctgc caatctagtg cgtacattac atcgttcttt ccagtaccta attgaaatgc 3806521 ttttaaaata gaagtctcta aatcacttag cactccgctc acatcattat gaccagcttt 3806581 actgctcatc gcgcttgaga tatcaaacac tcgatatgga tcaggcggga tgatgtgatg 3806641 acatctgctt ccgggcttcc attttatgat cttgttcact tctgaccaga tgcggtcttg 3806701 ttttgtctga cttaaagcgc gccaattcat cataatctca tccctacacc ttattggata 3806761 tcctgcttat aaacaccaga agaggccact gcgtaaacag cgtaacttgt cagtttcagc 3806821 tgttgaacat ctaggccttc accgttcgaa tcacagcatg ttatctcttc catctcttga 3806881 ctcacatcgg cagaaatcaa ataaagagac gacttaaggt ctgcactgta acaattgaac 3806941 gtcccaacca aaaaaccttc ttcggatatc gcgagctgat caaatgcttc tgagtccggc 3807001 tctttatccg acagaatcca cacccgtctc acgaccgttt catcaaatgc ggcaatgact 3807061 gcatctccgt aatacagcat ataaatcaag ccgttttttt ctgcaagtcc ataacaatca 3807121 tctacagcag gcgcatccat ttcttcaagc tttctatcaa tgtgtatttc cttctgctga 3807181 ccatctaacg taaaacacca cacactatgg ccgttgggat tctcatcatg ataaatccct 3807241 tcatcacata aaccgaccca aagctgttgt ttctaatcca aaagacagca ggaaacccct 3807301 gaaggcaagt gaaaaacact tttcaccctt ccctcttctg aaaaaacctt taccttcggc 3807361 tcgtacgatt cgtaataaac gaagacatag ccatctgcac attgttgaaa gagcagaata 3807421 tcactgtatg aaatctgctc tttcactcta aaatcccgaa catcaccgga aggatcatag 3807481 attgtaatgg tgataccacc tttcaaccct tttccaatgt agacacgccc ctgtggatca 3807541 gcatggaaaa aacaatcttg ggtgttctcg ttgatgattt tattcaattt taattttttc 3807601 attggttatg ctcctaggtt cgaaatgaaa tgataagaat aaaccattta ttagctatta 3807661 gtaacggaca acctagtttc attaatcgtt ttgggataaa tctactttcc aattcagcct 3807721 taaatcattt agtgtttaat tggtatgcat aaaacgattg atcatcaaag cgaactgttt 3807781 cagcttctat agcaatcagc attctgttca tgtcaataag aaagttagca tttgattgat 3807841 actccggaat tatagaattt gatagattcc cgattccttc tggatgataa ctcatctcaa 3807901 atacttgcca attgtattct tccggatcta ttttttccaa tctcatgtcg ccaacatctg 3807961 cactataata agcggatgcc acattttgaa atgaaatttt atgcgtatat tcaccttcat 3808021 cttcaaaaac cttaatatca agtgagagtt cttttttaaa cacattaaaa tctaaatgaa 3808081 ggacactgca ccccttatct atataatcaa cccattcatt aatcgtttga tacattgtca 3808141 tcccctgcct ctttttaaac aataacgcct tgccaccaag cagaaaacaa attactccgt 3808201 atattgtttg atccaatcat ttaaatcatc tgttgaatgc aaataagttt ctgatgaatc 3808261 tttcaaatca atcccactta gaaggattaa catatcccag actctatcgt cttctacttc 3808321 ggggtcatcc gcataaacat aagttccagc ccaatccgac acttcttctc ttgttgtttg 3808381 tccatttaag acacttttga ttttatttat gcattctatt agatttgtct cgctcaattt 3808441 gatcaccacg tattcaagta ctaaatgatt ttttattagt atgcaaagca ccgtactgat 3808501 atttagatat tgaagctttt tccgtaaaag atatgttcca aaaggtttcc aatctaccaa 3808561 taaacaagct cacatccgta ttccgtgtgc aatatacata aaccaaactg gcacttaggc 3808621 tcaaccaaaa taaaactatg attgagaatc ccttcatcga actcaataca ctccaataag 3808681 cagtcaaggt gctcgagaca ttttccaaaa gaacaaacta acgcaccaat ttcgctgctg 3808741 tattgatgaa acagcagaac gtcccggtca tcgtaagcaa catatgactg agatattttc 3808801 cagatcagct gtttcgcttc cgttttttcg agggcatcaa cctcacgggt gttggctggt 3808861 attgaatttg ataaaaccag ctcaagcaat tgcctgcttt gcgccagatc agcaaaacga 3808921 taagtgaagc ctctttctgc acaagggact agtttttctt tgatttcgct catcaataaa 3808981 cgtcttttat tctcggcgag tttttcgatc aatctttttt gcatgagccg cattccctcc 3809041 gctgtcaatt tctcaacttc ttttaaattg attcatcatt ctcttgtttt cgttgtcgtt 3809101 catgtttaga tttgttctaa aaaagcttgt atcgcttatc gatacaagct ttatcttcaa 3809161 ctgcttaaaa ctcacccagt gggcttttca caaaacgctg ggaacctttt tggcaaatcc 3809221 tcttcatccc aatcaattct atatttttag attcttttgt catacaaata agagaggatg 3809281 gtaacatctc ttatttaatg ttccatcaat aaatgcccca tttttatcca atgcagaaat 3809341 tatttataat taaggaagtt tagaaggatt ttttgtattt tcaagattta attttaaagc 3809401 ggtcacaaaa gactctagct tttcttcatt acaattaatt tcgaacaagt tggagttcga 3809461 cttactttct ttataatcat caaatataat tttaatctta attctgtaat ttccgttttc 3809521 ttgatcaata ctaagaaata agaatggttc aatagtctct aaactgatac tgtcttgatt 3809581 tccttttatc atagtttcga tcccagatat caacacctta tattcacttt ctaataaaac 3809641 agcagaaaaa tcgcgaacga cggctttctt attttccaac aattcaaata cagataaaat 3809701 aaatggatca tcgtccaact cttgatacct tctcggtgtt aattcaagtt ctatacaatc 3809761 atcttttatt ttggccatat ttcctcctca tttaaagttt aagtgagggt agttgtcatc 3809821 cccccctcgc ttaaccttat taacgccttc tcttagattt atttcctttt ccgtgtgtat 3809881 ggaatacgtg tttagaaccc ttagctcttg aacttccata agctgtgatt actttacccc 3809941 ttttatttaa aacaactgta gctttttttc caacatattt cgttgcccca ttaggttgtt 3810001 ttattacttt tttagggctt cgcacagcat tcagtttggc ccttaaattg actccacggc 3810061 ctccatttct tcctatagat tgattaagtc catgtcttgt atgacctgtg attttaactg 3810121 ccttcttcgt aaacttatag gcgcgactag cacccttaaa tatcttccca ggaccaaaat 3810181 tagaagcagc tgcccaagca gcacctttcc atcctttacc tgatttatat gccttatatc 3810241 catcataggc tgcaaatccg gcatttacca caagccatac ccaatgcccg tccggatcaa 3810301 cattcatcac tgggttatta tttccataag catacccatt ctgatccaat gaatctccgt 3810361 cgctgcccgg gtctgggtcg agcgatagga acacgccgtt tcttggctcg tagtagcggg 3810421 ccatgagata gtacaggccg gtttcttcgt cgtattggta gcctgcgtag cggtagcgat 3810481 tgtcttttac ttcgtcgctt gcttcggttt ttgttggatt tccccatgcg tcgtattgat 3810541 acttggcaac ggtttttcca gtgctgtctg agatcgcgat gatgtcgccg tgagcgttgt 3810601 agtgatagaa atatttctta ccattttctg tgtaggataa cagctggccg ctgtctccgt 3810661 acgtgtatga ttttgtgacg ttgttgtccg cgtctgtttc atacaagacg ttcaagctgt 3810721 ctccgtcgta gaagtagttc gtgacttttc cgttgacggt tttttggatt ctgtttcctt 3810781 tttcgtcata cttatatgtt gcgaatggct tgtcttcgcc ttttttggta acggcggtca 3810841 ggttatcttc tgcatcccac gtatatgtga atttgccgtc ggatgtgcgg ttgccgtttt 3810901 tatcgtaaga gatgctttca tcattgactt ttgtcagctg gttcatgatg ttgaaggaag 3810961 cgttcaccgt tttgcttgag ccgtctttta tagttgtaac ggttttccgg tttccgaatc 3811021 catcatatgt gtattcaata acagtaccgt cttcatgggt ttctttgaca agctgattca 3811081 gcttcccata ctcatattgc accttgccgc ttgctgagct gtttatcgtt gtgcggttgc 3811141 cgttggcatc atattcatag ctttccgtca gaatgtctcc gccgtttttg tcaccgatat 3811201 gcagcgagct tacaaggttt ctttcgtcat atgaaaaact tgttccgccg ccgttgcccg 3811261 taataaaggt ttggacgttt ccattttcat cataatcaaa tgaatatgag gatgtactgt 3811321 ctttcatctc aatcatttga tccagcttgt tatacgtaaa ttgattcgtt cctttttggt 3811381 ccccatgaat ccacgagaag gttttcagct tatcggagtc actaggatat gtccaagttt 3811441 ggctgccgcc gcggtctgtc agttcggtta aacggttttt gttgtcaaat gtccgtttct 3811501 ttgtggtgtt ctgctcttta ttgacgaccg acgtttcatt tccatttttg tcatacgtga 3811561 aaatgtactt ttctgtaccg ttatacgact ttgatttcac ccggtctgtt ccatcataag 3811621 aaagagacac ttcgttgcca tttggtgaaa tggttttggt caggttgctg ttggcatcat 3811681 attcgcttgc taacacattg ccgagagggt cagttgtttt gacaagcttg cccatgacat 3811741 catattcgaa tttataggtt tgatctgctc ctgcccggat ggttttgctt acctcattgc 3811801 cttccttatc atagctgtga aggatagacg tgccgttaga gagcgtcatg tttgtcaatt 3811861 ggtctgcctg atcatacgta taggttgttt tttcaccttt tgcatctgtt tcagacgttt 3811921 tcttaccagt ttcatcgtaa tcagttgaag tggcgtaacc tagttcgtcc tcttccttgg 3811981 tcacatagtt gccattactg tcatacgtgc ttttagtcag aaggcttcct tcaatcaaac 3812041 ggatatcatc aaaccagact gtgcctgtcg cactcttttg gaacagaata ctgatatcga 3812101 ctttattgat cggctttgtt ttagggatga cgacagctgc tcggttccat tcctgtgttc 3812161 cagaagggaa tttcgcattg tagatgcctg tgctgccgtc agcgtaagtg acattcgcct 3812221 gcagagaata gtctttttca tctgtaaatt tgacgctgct tgctttcgac attcctgtca 3812281 gtgtgagata aaccggtttg tcatttgcgc tttgccctaa gacaacggtt tgttttgtta 3812341 ctgatccggc ttgggacgca ctggtccggg cagcttttaa tgatacatca tcattaaagc 3812401 cttcttcaga atcaacggat gctccgctta cattccagtt ttccgttgct gatgtgaagc 3812461 tgctgttttg aactgggtta tagcttgatg atacttcgcc tttttccagc tggacttcat 3812521 caaaccatgc ttttcctttg ccatctttat ctttatgatc gacttccata tacacaacag 3812581 ctttgcctgc attcgctgga gtcgtaaaag tgatttgccg ttttgtccag tcattttttc 3812641 cggctaatgc actgtattca ttgtgaatcc attgaattcg tttttgatct ttgtctcgca 3812701 aatcaatgtt aaaataggct cttgatttcg caagatctgt tttgattttc ccgcttaatg 3812761 tataggttgt attcggctcc agctcaactg tttgtgttgc tgacgaatac ccatgatctg 3812821 ttccggcaga cgttgattgg ctcaagacct ccaatgcctt tgatccggaa agaactccgc 3812881 ttttatcggc gatgactgaa attttgccgc tgtctttaga ggcagtcaga ttccagccgg 3812941 atttttgagc ttcaaagctt ccatctttca aaatattagt tgaagctgat aaatctttgc 3813001 tcgattgaat ctggtttcca tatttatcat aaacagctgc tgacgatgat tttccgctct 3813061 gatcggtttc ggatacagca tccagtccgt cataagcaat atccgtgaca ttgccctcgg 3813121 tatccttcat ctttgtgaca tcgttgtttt tgttgtattc gtatgtctca gttccatatg 3813181 catctttaac cgacgtaacg ttgccatctt tgtcatattg atagctttcc gttgcttttc 3813241 cggtgccgac gtcatttgga tctacatctt ctacaacatt gttgccttca tactttgtat 3813301 tcgttgtaat ttttaaccct tccgcatcat caatgacctg aatcggattt cccgcttcat 3813361 tatagccata ctgtactttc cggccatttg gctgtgtcat gagaagcgtc tttttatcag 3813421 catcatagct gtagacatat gtttcttttt tagcgttgat cgctttttcg agacggtgac 3813481 cgctatactg atattcggta aagacaggct ttgcttcggt actgttagct gaatattgtt 3813541 tgacaaggcg cccttcacta tcgtagtcat agcttgtgac agtcccgtct gtatctgtaa 3813601 ccttcttcag caaatcattc tcatatgagt aggtgacttt cttattctta ggtcctgtga 3813661 tggacgtcac atggccgttt tcatcatagg taaatgtaag cttgcggcct gatgcatctg 3813721 taatggcggt cagttgattt ttgtcattgt aagtatagac agttgcattg ttatggccat 3813781 ccactacctt ttggagtttg ccgccttttt tattgaaata agcgttggtt tgatcctttg 3813841 tttttaatat gaactgatca gctgtttctg ttaattcaag atatacaccg gtcggcggct 3813901 gatacgtgcc atcggctttt ttcgtgaatc gatgtgtcgt agcgtcttca tcgatataca 3813961 ttgccccgcc atccgttgag atgacagatg tttctgcatc agcataccag ccttgtccaa 3814021 ataagtgatc agagctgtca agactgttgt aggttctcga taagccaagt cccggaccgc 3814081 gtccatcaat tgacaaatct tcttcattca caatgacatt gcctgtcgca ccatttaact 3814141 ggccgcttgg gatatcaatg atagaccagt actcttctgt acctaggaat tctgcgcctt 3814201 catggaacgt tgggttaaag ggcgccgttg gaatcgtttc accattcgca tcataggcga 3814261 caagcgtgaa agaataattc ttcttccctt tgtaattccc atttgcattg ttatagacag 3814321 gtgatggatc gagggctaat tccccgcctt ttccatctgt atgaagctta tagcttccgg 3814381 ctttgatttc ctcagaagtc ggccagatgt ttttattttg ggttgtccaa tgatcagcat 3814441 caccaacatc aaaggactga tattctttac cgttgtaaat gttaacttta tagcccttcg 3814501 cattttgaac cttttcccat atcaaattca cataacccgt ttgactcgat tttgtatttg 3814561 tatacaaata gccagttaca ttctttggcc tagcgatatc aggaagtgcc ggggtagcag 3814621 ccggggatgc aatggcttcg ccgtctttgt tgtatgcgat aattttaaac gagtaatttc 3814681 ttttggctcc atctcccccg gcgtttttat aggttggtcc gggattgatc ggcagctctg 3814741 ctccgcttcc gtcctttagg tgaagagcat attttcccgc cttgatttct gcacttgtcg 3814801 gccagatctt tttccctttt gtggtccaag acgtctgatt tccgagatca agtgtctcaa 3814861 agcctttccc attgaacacc tgaaccttat agccggttgc accggataca gctttccaag 3814921 aaaggtcgaa gtatcctgtg gcattcccat tattgtagcc ctttgctgac ggtgcttgtg 3814981 cttttcctac attagggata acgggctttg ccggtgcgga catcgctcct tcaccttggt 3815041 caaatatcgc actgacgcca atccaatagt ttttgcttgt agcatagctt ccgccggaat 3815101 tcttatagac cggggatgga tctaatgcca attcagctcc atccttgccg tccagatgca 3815161 gtttatatct cttggaggca atttctgcgc tcgtaggcca gattttttta ccttttgtgc 3815221 tccacgacgt gacgttgcct gcagaaatcg cttgatattc cttaccattg taaatccata 3815281 ccttatatcc ttttgcgcct tcaacctttt tccagctgat atcgaaataa ccagtggaat 3815341 cgccgttgtg ataggctttg attgtaggtg tgtttccctt tggaatggta tacgtcactt 3815401 caatatatgg tttattggcg gagttcgctg aagaaattag ttttttccaa tattccttgc 3815461 cgtttccgtt tgtatgaagc ttaaatccat agttggcccc gccggagttc catgacttta 3815521 cagcagcggt cacatcataa ctcgcccact gtcctttatg gacgtcggct tttccgatat 3815581 ttttagatgc cggtttggtg ttccatgtca cttttgcatt atcataattg ctgttgaccg 3815641 tatccagcca aaggccggtt gcctttgttc cataatagga atgggctacg tatgttttta 3815701 atgtagcttt agtgacagtc atattttgaa ttggctttag gttgttaaat ttcatgaacg 3815761 catagtttgt gcctgttgtt ttgtcataat agcccgtttt cagtacatag gcctttaaat 3815821 tagcatccca tttttgtgag gaggccgaat agttcgtcgt cgggtaggca ctcatgacaa 3815881 acgtatccga tgaaacagat aaagaagttg acgggtcgat agatactgga tatacgcgtt 3815941 ctgggtcttt cagccagttc tcgtctgccg taagatgaag caaataccct tcttcattct 3816001 tttccagctt atagctgact ttgtctgacc gttcaacctc gccggaaagc tcatctagtt 3816061 ttgaatccgt cataaaaggc ttaggcacag aaaaaacaac ttttcctttt tcatcagaaa 3816121 aatcaatgga tccatcctct tgttctttag cctgcaaatc ggtttttaac tgaaatgtaa 3816181 atgtgttgta tccattatac tgatgaagga ctaaatcttc ttttatgttt tcattgaatg 3816241 tgaaagtctg aagatcaata ttcggaaaca catccggata cacaatctca ttactgtcag 3816301 tcttataatc tgctgaggta tctttcggag taagtgaagt tttattcggg cctttcgctt 3816361 ctgctagtga atatgtaacc ttatggtcat tatgctcaaa agtcgcataa agcccgttct 3816421 tcatttgctt ttgaaaatct gaattcaaaa tagcgttctc tgtctcgact tgtttgcttg 3816481 tcgactcttt taactcagga gaaatgtctt cccagtcggc atccggtgtt tcctttgtat 3816541 gaataggatc aaggtatact tcctgtttat agacaccgtc accttcataa tagagttttg 3816601 tattttctgt tctttcagag gtgatctcac cctctttgtt tatatctttt ggatcaaaag 3816661 gtacagcttc ctcagtttgt tctttctgaa gagtttcttc tggatcatcg gcagcaatac 3816721 ggtttccatt ctcttcttct gtagattttg ctagtacatc ggctggcact aatgaaatca 3816781 ttaaagccaa cactaaaaat gctgcaatga accttttaaa gtttcgcctc tttctttttt 3816841 tcatttcctc tctccttttg taataaaagt aatatttact caataatctt aactagactg 3816901 aaatatcatt acaatatttt tctagaaaat ttatcttatt ttaaggatta gcgagagtca 3816961 attgacctaa aacaaaaaaa ggccgcatag gcctttttac attttttatt gtatttgttc 3817021 aatatccgta ccctcagctg tcacattcgc cttcccctgc ctcctgacaa gcgtcaaggc 3817081 catgcccgca aagatcatta cgatgccaag cgtttgatag aggtcagggc ggaagcctgt 3817141 gaagacggta tcgagcacga tcgcgacagc ggggtcgaga aatacaatga ttgaaataaa 3817201 tttcgttgat aaaaatcgta aactgtcaaa aaacagcaaa tatacaatac ccgtatggat 3817261 gatgccggta gataccacca taatccagtt tccctgagat aggtccgcaa aagcgccaaa 3817321 gtgaataaac ggaatcagga tgataacccc taaacctgtc tgcaagaagg tggtcgtgta 3817381 aggactgaga ttgtgaatgc cttttcccaa taaagtggtg aacgcataaa acagtgcggc 3817441 gagaactgcc catatgatcc ctgatcccat cagctgtgtc aatgatgtgc tgccgttaat 3817501 cccggaaatc agcgcagtcc caagaaagca gatgataatg gagctgacgg agatcacatt 3817561 taatttctct ctgtagaaga agctccccag aagaagaaca agcaccggcg ctagatgata 3817621 aacagagatg gcaattgtaa cggacgtttc ttcaaaagac ttaaataaga acacccagtt 3817681 gaatacaaga aagaaaccgc acgccaatgt ttgcagcacg tctctcttgc tccatttttc 3817741 agttttatac tggccggacg ccagccagca aaagcctaaa aacagcgtcg cgcaaaggca 3817801 gcggacaaag accaattcaa atgacggcag attggtatgc tctgagaaaa agccgatgga 3817861 gccgaaaatc accatagaga tgaccatttt gattacggct gttgattttt gttttgacga 3817921 tatggaagga tcctgttgca tcaaacgtat tctacctcca atactgcata gcataaactg 3817981 ttttttgtga attcagaaat ctacacatag aattcctctt ttttacatgt agatattata 3818041 acacttctat tctaaataaa aaaaagcgcc caagggcgct ttttttacaa atctatcgaa 3818101 caatcaaaac cgggcatgtt gataattgag acactttatg gctgacgctt ccaagcatca 3818161 tttctttcag gccgctgatc ccccggctgc caactacaat caggctgacg cctttctctt 3818221 ttgcgtgatt tagtatctca tgcgccggct cgccattcgc gtaaatggtt tcagcttgaa 3818281 cgcctttttc ggctgctttt tcttttgcat tctcaaggat tttcaggccc tcttttttaa 3818341 cctcgttcct gatttcatca ataaagtgtt caggcacata gacaattccc gtcagagaag 3818401 aagtcgtgac gacggcttct ctccccacat gaagaatgct tagttccgct tgttgctctt 3818461 ttgccaaatg cactgcggca tcaagcgctt ttgcactcat gtctgatccg tcaatcgcta 3818521 ctaacatttt gttaaacatg ctcttcccgc ctttcggact gtgggtggtt catctttctc 3818581 ttttattgtc cgcctgcatt tcgttattgt caattgaagc gcatgagttt tcaaaaaatt 3818641 gtcagagact ctctccgttt gtggcgataa cctgctgata ccagttgaag ctttttttct 3818701 tgatgcggtt aaatgttcca tttccttcat tgtcccggtc tacataaatg aagccgtagc 3818761 gctttttcat ttccgcagta gatgcgctga caaggtcaat tggcccccat gatgtgtatc 3818821 cgattaattc aacgccgtcc gcaatggctt cgcgcgcttc aattaaatga tcacgcagat 3818881 agttgattct gtaatcgtcc tgaatcgtgc cgtcctcttc aaccttgtct acagcgccaa 3818941 ggccgttttc aacgatgaac agcggcttct ggtaacggtc gtataaggtg ttgagcgtga 3819001 tgcgcaagcc tttcggatca atctgccagc cccattctga tgatttgagg taagggtttt 3819061 tgactccgcc cagcaggttg ccccctgatt ttgcaagctc ttccggatct gtgctcgccg 3819121 ccatcgacat gtagtagcta aatccaatat aatccaccgt atgttctttc aagagctctt 3819181 catcgccttc agccatttca atttcaatat tgttttctgc cagatagcgt ttcatatatc 3819241 ccgggtatgc gcctcttgcc tgaacatctg agaagaaaag tgttttgcgc tcattctcca 3819301 ttgccgcgaa gacatcctcc ggcttagaag tcatcggata ggttgtcgtt gccgctatca 3819361 tacagccgat tttcgaatca ggaatgatgt cgtgacccgc tttgacagca agagcactgg 3819421 ccacaaattg gtggtgtgcc gcctggtaca tcgcgtttaa tttgttttct ccttcttcaa 3819481 aaacaagacc gcctccggta aatggcgcat ggagcactac gttaatttca ttaaacgtca 3819541 tccaatactt cactttgtgt tgatagcgtt tgaaaaccgt tttggcatag cgttcataaa 3819601 actctatgac tttgcgattc ttccagccgc cataattttt cactaaaccg agcggcatct 3819661 cataatgaga gatggttacg acaggctcaa tatgatgctt taacagctca tcaaacagat 3819721 catcataaaa tctgaggcct tcttcattgg gctcctcttc atcgccattc ggaaaaattc 3819781 tcgtccacgc aatcgatgtg cggaacgcct taaatcccat ttctgcaaat aaggcgatat 3819841 cctctttata acgatgataa aagtcaatcc cgttgtgata cagattcaag gaagtcattg 3819901 attcatcaaa tggagacatg atcccgttcg gcgatacgtc agctgtcgaa agccccttac 3819961 caccctcgtt ataagcaccc tccacttggt tggcagcaac tgcgccgccc cataaaaatc 3820021 cttctggaaa tcgtttttca tttgaactca tattgatcac cccattagtt ttttcaagat 3820081 aaagcaagca gcgcttcttt tggctgcact ttaccgatct ctttcaccgg cgaaaacgaa 3820141 tattggtctg tgttggtcac aatcaccggg gtaatgacgt catatcccgc ggctttgatt 3820201 tgctccagat caaaggacac gagcggatct cccggtgcga ccttgtcgcc ttctttgatg 3820261 tgagccgtga accattgtcc ctccagcttt accgtgtcca atccaatgtg tatgagtatt 3820321 tcagctccct gatcactcgt aatgccaatt gcgtgttttg ttttaaaaat ggtggtaacg 3820381 cttccacgaa caggcgaaac aacttctcct tcttcaggct caatggcaaa tccttttccc 3820441 atgaccccag cagaaaacac tccgtctttg acttcactta aggctttcac ttctccctta 3820501 atcgggctgt gaatgatctc tctgctgcct tcatgcactg ccggctgctg gctgccgtca 3820561 gaaggcacat cctcgaatcc aagcaaatac gcagctgctg ttcccgccgc aaacgcaatc 3820621 acaaggccga tcatcgcgta aataaacgtt gggccgataa agacagggat gctcggcaga 3820681 cctgcattcc ccccgacgat ataggaagca acacccgtca tgccgtaaaa cgcgccaccg 3820741 gctgcaccgc caatcaaagc ggccgcaaac ggctttttca atcgcatatt cacgccgtac 3820801 atcgcaggtt ctgtgatccc catcagcgcc gtgatgcttg tggtaagcgc gagtgattta 3820861 aattttttgt ttctagagcg aaggaagacg gcaaatgatg ctcccgcctg ccccatattc 3820921 gccaaaaaca tagccggcag taaataatcg tggccgtttt gagcgatgtt gttgatcatg 3820981 atcggcacaa aggcatagtg catgcccgtc ataatgatta aagagaatgt acccgccagc 3821041 aaaatcattg ccacaagccc tgcatgatca aacaaataat tgaccccaga agacaagtat 3821101 tctcctaaaa tagcgccaag cggaccgact gtaatcaatg tcagcggcac gacaatcaat 3821161 agcgtgaatg tcggaaccac aatcaatttg agagatgcgt gtgtaaaacg gtcaatccat 3821221 ttttccacgt atgaagcaat ccaaatcgac agcaaaatcg ggatgaccgt tgacgaataa 3821281 gtggcagcgg ttacaggaag cccgataaag gaaatcggtt tccccgcacc gagcagggct 3821341 gtcaaatccg gatgcaggat cgccgccgca atggcagccg ctacgtacgg attgcttccg 3821401 aattttctcg ccgcactcat cgctagcagg agcggcagga agtagaacgc accgtcaccg 3821461 acagccgtca aaatgacatg aacctggctc ttctccgcca tccagccaaa cgtgactgcc 3821521 agcgccacaa gtcctttgat catccccgct cccgcaatcg caggcagaat aggggtaaac 3821581 accccagaaa tcacatcaaa gaccgcactc agcacattct ttttctgaga ggatgaacca 3821641 gcgctctttt catcactgag attgctgtgc cgcacaatcg cctgatacac cttcggcaca 3821701 tcgtttccga taatgatttg aaactgctcg ccgctgatat tggtgcccat cactccaggc 3821761 agctgctcca gctgactgcg atccgccttc gcgttgtcat gaagattaaa acgcagcctc 3821821 gtcatgcagt ggatcacgcg ctgaacgttt tcttcaccgc ctacgagttg taatatgtcc 3821881 ttcgataatt tatcataatc catgtgtata cctccttttt atggggggac tgctggatga 3821941 aaggtggccg cctttcacca gctttttttg tatcaaatgc tgcatcacct cctaaaagag 3822001 aataaaaaaa cctaaatgac acagattgcg agagtctcct cctgcacctg caccatttag 3822061 gttttgcctg ctttcgcagt aacaatcctg acgggtcgtt ttatttgttt gtaggtatac 3822121 tttagcacta gattcgtgag atgtcaacgc tttcattttt ggtgttgact atcgtttcta 3822181 gaacaaaagt aatcataaag atttgaactt agtattaact tcaataaaaa attattgtaa 3822241 ttaaaaacct tgaaaggcat tttttccaat caaggttatg aatcgttacc gtttaaattt 3822301 ttttaaagac ttctttatct gtactattac attctttagc caatctattg gttctaaatt 3822361 aaacgcagga agatacacgc catctgcgca agattgaatg taatcgtttt tcttattgtc 3822421 tgaatgctca ctttcaataa aatccgttaa aaagacaata gcatcctcca aatattcctt 3822481 actttcctct attaataact cttgtatagc gtcatcagga gtttcaatat cttgatggaa 3822541 tgttccagct aaaaactgaa aaacagggtc cttctgttta ttgatcaata acatgtcatc 3822601 ttgctccttt aagggagagg taacgggata atgttaaaat cattcatcat ctaataaatc 3822661 aagataatac tgatcattct cttctatttt tcttaagaac tcggtaagag aagttgcaat 3822721 ttgaatatca taatagtaaa tcggattttt attattatca tttaattcaa ttgacattaa 3822781 tgccgattca ctaccttcaa aaaatattaa tttatcattc tcaaactcat catatatttc 3822841 tatgtcagga taaaattcaa agtcatttat cctcaatcga aagtctctta cagaatatgg 3822901 atccaaaatg cgattagtat taaactctga tcctttaata aacccatagc caacttctaa 3822961 ataaaaattc actaattcac taggtaattt taagtttaaa tttttttcaa cctcttcaat 3823021 ctcactttga ttcactggat aaaaatcatt ttctttgttt gattttataa aattataact 3823081 catttttttt tgcctccttt aaataattca tttgctggtg agcctgtacc atgaatccca 3823141 gcttgatgct cgttaggaaa ttttgctgga tgcatattcc accattcatg ttctccgcca 3823201 aaagtatttt caattatatg gtgagcatca tacttatccc ctttttttct aataatttta 3823261 cctgtttttt cagatacaac attttcctta taaacaggcc atttttgtcc agtgttttct 3823321 tcccattctt ttataacttt attttttact ttatcaaatt tagtcctgtg ttttgcagtc 3823381 tctattggtg acattttttt atattcttta tttcttaatg cttcctttaa tttatctatt 3823441 tgatttttag gtaattctct acctgtgcgt tgttctatat ctctagcata cttttttatt 3823501 aaatcagaat taattttatt agcagatcca cttacatcat tcgcaatttt ccctttatcc 3823561 ttagcaacgt ttttaacttc cgaagccttc ttagcctttt tcccattatt aataagttta 3823621 ttaatatcta ttaacttttc taacttagct attttggcaa atggtactga gtttatggag 3823681 gcaacaacac ggtctttccc tgtgactttt tcgcctgata ccggatctct gcccgtggct 3823741 gctttaaata gatcatacac gccggtaagt tctacagccg tctctaaaat tttcacatat 3823801 ccattctcat ccactttaat gtccgaaagc gagacgacag gttcaagctt catgtcatta 3823861 ccagatatgt atacattgta aagtgtatca ttataaacga cttgcttaac ctctgcattt 3823921 gagaaatcag tttttatatg ttctctatgt tcactcgtat tatacacttt accattgata 3823981 acgatgatat ttttacttac ctttttagaa tcacccgttt tgacaactga atccacttta 3824041 gacttttcat tctcggctaa tttcttcagc atcatctcca tcggtgaatc atccgcctgc 3824101 ttcatttgcg ggttaatcgc gccgaagatt tggttgatgt tttcttcttc ctgtgatttc 3824161 aggatggagc cgcttttgta gcctgtgatt tcaattttcg ggccggtgta catggtttcg 3824221 agctgatcaa tgtatttttt catcgtttga aaatctgatt ttgcggcttc tagtgcttgg 3824281 gtttgctggc cgtcaaattg aaagagctta ttcagggtgt ctgaaatcag ccgctcagcc 3824341 tgttctgttt ccatccgaaa aaaggaatca ttgactgtcg gcaggctgac gatgtgatct 3824401 atggctgatg tctggcgatt gactgcgtca gtgagctgct ctgtcacttc tcgtgcatgc 3824461 ttgaccccat gtctcgcatc gtgtgagaga aaagcctctg cgatcatgcc gtgggagtta 3824521 gattctacag aggaaatcgc atgctgtgtt tgtttcagca cttttttgta ttcgtcgata 3824581 aatatgccaa agaaaaggag aaaaggcttg tggcactcct cgtaaaaggt ccggatggca 3824641 tctccgcctt ttcctttcag cgcatccttc atgcctgcca gatgctcaac gcttttttcc 3824701 agcttctcca gctgttgttt ttgcttgtcc agtttctcaa tcgtatgctg aatgccctcg 3824761 tgaagagcgt ggacatctaa tgttttcaat cccttgtcct cccgcgcttt atttcatgga 3824821 agatgatatg ttttcgtccg tttccttcat ggcgtttacc gcgctttccg tttgtgcgat 3824881 atgcttggcc agaacagacg catatgcttc agtgagctct ttgatgtcct tatttaattg 3824941 ctcgatggac ttcacaacat tcaaatggtt tctgcctgag agatgaccgg gcaatgagga 3825001 cttgagttca gctgaattct tgagctgaga aagcccttgc ttcactgtgt catacaccat 3825061 tttaatttcc tgtgccattt gtgctcacct cactttttat gtttttcctt ctctatttca 3825121 tgctctatcc tcgtgatttg gcgtcttata gaatacacat cgccctctaa tgagtggatt 3825181 tttccttcta tgctttcgat gattccgctg acttgatcgc ttttgatttg ctgatatgct 3825241 ttgttcattc cttcacgaat atcttcaaac cgctcagcat gtgttcctct ccatgcctcc 3825301 cggttaagat gaggccggtg aatgagatgc tgggcctcag agaaatcgtg tttgatttgc 3825361 ctaatttcgt gcagcactcg ttttaattga tggatctgtt cctgcttttc atgtaagtcg 3825421 gcttttaccg aatgtaacaa catttcacta tgcatgccgc aacacctcgt gtttctatca 3825481 aactgtgtaa attctttaca atacagacta ttttcatatt acatgatggg tcatattgga 3825541 taaataggta aaaaggattg tcttgagagg tatagaactg gttctaaatt gctaaaaata 3825601 cgatctcatc accctatgaa aggagaaaac aatcatagta gggacttttt atttaagcct 3825661 ttaatctctc ctccagttct aatttttcct cccacttaac tgtttcttat agtcaataaa 3825721 gctcataaaa aaacaccttc cctcgaaggc gcttctccat cttatttaga tccccataca 3825781 gcctcaccgc tggtattcag cacactaaac gtcatgacgt tcttctctct caccgaatcc 3825841 cactggcgta aaaatacccc gttatacttc ttgcctgcta acgtgatgtc ggcggtgttt 3825901 tttccggttt tcctccatgt tccggtcatt tccccggaaa tggtgtggtt tttgttgagc 3825961 tggatgttga tggtttgttt gatgtcggct gagatgtctt ttccgtgctg gataagtttg 3826021 tatgttcctg tgatgtcttt ttgttttact tctttcaatg tttcgcccgc ataacgatat 3826081 ggtgctgcta ccggccagcc gtctttgttc atgaacaatt ggtggactct gacttcgtgt 3826141 tcttcacccc tgcccgggaa gcgggtgtgg aagattaaat aggaacgccc ggttttttca 3826201 tcatagtatg cggagttgtg gcctggtgag acgtacccgg tgcctttttc attttctgtt 3826261 tcaaaagtgt agctgcccat gagtttgacg ccgtatggtt cgatggaacg gtcgtcgaag 3826321 aatgtgcctc ccttgccgcg gacgtcgagc attggattgc cttctgcatc atagtaaggg 3826381 ccgtccggtt tcttggagcg ggccacacgg atgttgtagc cgcctgttgc atcgagaccg 3826441 ccatatgata ggtataagta gtagtattgg gtgtctggat tgtagagaac atacgggcct 3826501 tcgattctgc tgtggttgcc gccgagcagt tttttcccat atccctgtcc aggaagcggg 3826561 aagcccgttt tcggattcat ttcaagtatg aaaatgccgc ctgagtatga tccgtacacc 3826621 atccacagct tgccgtcttt atcaaagaag gtatgcgggt cgacgacatt cggatgtttg 3826681 gttgcatcat acggtgttcc atcgctgctt gtgccttcca ttcctgattt caaaaagatg 3826741 cctttgtttt tgtatgggcc ttcgatgttg tcagcaacgg caacacccat ggcggatctt 3826801 ggcgaatcgc cgcggcaggc gttgtagtac atgtagtatt tgccgtccgc cagctgcgtg 3826861 acgtcagccg cccaaagagt atcggattgc gcccattcga aggtttcttt taattcttca 3826921 tagacattcg ggataagtgg gttgtcattg cttacgctgg tggtcagctg ctgccattgc 3826981 atgaggtcat tcgatttagc tgaagcgaga tgagatccaa aaacataaaa agtgccgttt 3827041 gtttcaatga tggaagggtc atggacgctg acttctttaa atataggttt ttgtgcatag 3827101 acggagtttg ggagggtgaa ggccatgata agagctgcaa gaaaacatac acggaacaat 3827161 cggttgaaca tctaaacaat tcgcctctct tttttattaa attttaaacg cttacatttc 3827221 tctatgaaga taccccggcc tattaaaaca gccgaatgtt ttcatattca tccagatagg 3827281 tgatttctca cttcacttac atagtcagac tgatgtctgt ctgttttgcg cagaacttgt 3827341 tgcttgcata tcctctcctt catagttcaa ctcttttgct gtttctcctt cttgcatcac 3827401 gtctgttttt ctttcgcgta catgtaataa ctgctttgtc aggttttgca tcaactgtga 3827461 tacagccatt tcgttgtcgg cgttttttaa gatgatgcct gattgcccgt caacaccaga 3827521 gtcattcggc tggctcttta taaaacgcct tgcgaaaaat acgacttagt aaacgcatat 3827581 tgagagttag acagcggcgc ttgcctcctt gtctggatat cgtgtgcaat cgctgaaaaa 3827641 acctgttctg ctttctgcgt cacgctatta caatagcaat ctaacttgtt aaagactata 3827701 aaaaaacctt ttgacttctg ctgctgaacc aattaatata atactcagtt aatagttatc 3827761 agaattttta ggaattgagt gattcatatg acactgcata aagagcgtcg gatcggccgg 3827821 ctgtctgttc tcctgctgct gaatgaggcg gaagaaagta cgcaggttga ggagctggag 3827881 cgagacggat ggaaggtctg tcttggcaag gtaggatcaa tggacgcaca taaagtagta 3827941 gccgcaattg aaaccgcttc caaaaagagc ggtgtcattc aatctgaggg ttatcgggag 3828001 tcacatgcgc tttatcatgc gacgatggag gctttgcatg gcgtgaccag aggtgaaatg 3828061 ctgctgggat cgctgcttcg gacggtggga ttgaggtttg ccgttttgag gggaaatcct 3828121 tatgaaagtg aagcggaagg cgattggatc gctgtctcgc tttacggaac aatcggggcg 3828181 ccgattaaag gtcttgagca tgaaacattc ggcgttggaa ttaatcacat atgaaacagc 3828241 ccatagatct tagacgatag ggggctatgc gtgaaaacag aagttcacag catagctcct 3828301 ttttgtatgg gcgctttacc aaagtaaaga aaaaggagtt gggcttatgg tgactttaga 3828361 cggttcttca ttgacaacag ccgacgtcgc tcgtgtgctg tttgattttg aggaggcagc 3828421 ggcttctgag gaaagtatgg agcgcgtgaa aaaaagcaga gcagcagtgg aacggattgt 3828481 acgcgacgaa aagacaatct acggcatcaa caccggattt ggcaaattca gcgatgtcct 3828541 gattcagaaa gaagactcgg cggcgctgca gctgaattta atcctttctc atgcctgcgg 3828601 agtcggcgac ccttttcctg agtgtgtttc cagggcaatg ctgcttttgc gcgccaatgc 3828661 gctgttaaaa ggcttttccg gtgtacgcgc tgagctgatc gagcagttgc ttgctttttt 3828721 aaataaacgc gtccatcctg tcatccctca gcaaggatca cttggcgcaa gcggagatct 3828781 ggcgccgctt tcccacttgg cgcttgcgct gatcggacaa ggagaagtct tttttgaggg 3828841 ggaaagaatg ccggcaatga caggcttgaa aaaagcaggt attcaaccgg taacgctgac 3828901 atccaaggaa gggcttgcct tgattaacgg gactcaggcc atgactgcaa tgggggtggt 3828961 cgcctacatc gaagctgaga aactagccta tcaaacagaa cgaattgcca gcttaacgat 3829021 tgaggggttg cagggaatta tcgatgcatt tgacgaggat attcacttag cccgcggcta 3829081 tcaggagcag atcgatgtcg cagaacgaat tcgcttttat ctatctgaca gcggcctgac 3829141 aacctcccag ggagaactgc gggtacagga tgcctattca ttgcgctgta ttccgcaagt 3829201 acacggtgcg acttggcaga cactaggata tgtcaaagaa aaattagaga ttgaaatgaa 3829261 cgcagctaca gacaatccac tcattttcaa tgacggtgac aaagtgattt ccggcggaaa 3829321 ctttcacgga cagccaatcg cctttgccat ggattttctg aaaatcgcaa tatcagagct 3829381 tgcgaatatc gcagagcgta ggatcgaacg acttgtgaat ccgcagctga atgacctgcc 3829441 gccgttcctg agccctcatc ccggtctgca atccggtgca atgatcatgc agtacgccgc 3829501 ggcctcactc gtttctgaaa ataaaacact ggcccatcct gcaagtgtgg attccattcc 3829561 gtcatccgcc aaccaagagg accatgtcag catgggaacc atcgccgctc ggcatgctta 3829621 tcaggtgatc gcaaatacaa ggagagtcat tgcgatcgaa gccatttgcg cattgcaggc 3829681 tgttgaatac agaggcatag aacatgcagc gtcctatacg aaacagcttt ttcaagaaat 3829741 gagaaaagtc gtgccgtcca ttcagcagga ccgtgttttt tcctatgaca ttgaacgctt 3829801 gactgactgg ctgaagaaag aatctttaat acctgatcat cagaataaag aactaagggg 3829861 gatgaacata tgactgatgt aaaaaaatca atccgtgcca acagaggaac agagcttgaa 3829921 tgcttaggat gggagcaaga ggcagtgctt cggatgcttc gaaacaacct tgatccagaa 3829981 gtcgccgaga agccggagga cctcatcgta tatggcggga ttggcaaagc cgcacgggat 3830041 tgggacgctt ttcacgccat tgagcattcc ttgaaaacat taaaaaatga tgaaacattg 3830101 ctcgtgcaat ccggaaagcc cgttggcatg ttccgtacac acccgcaggc ccctcgcgtg 3830161 ctcctagcaa attctgttct tgttccgaag tgggcagact gggagcattt ccacgaactt 3830221 gagaaaaaag ggttaatgat gtacggacag atgacggctg gcagctggat ttacattggc 3830281 tcacaaggca tattgcaagg aacctatgaa accttcgctg agctggcgcg acagcacttc 3830341 gggggcagct taaaaggaac gttgacgctg acagcgggtc tcggcggaat gggaggcgcc 3830401 cagccgctgt cagtcacgat gaatgaaggc gtcgtgattg ccgtcgaggt tgacgagaaa 3830461 cgcatcgaca agcggatcga aacaaaatac tgcgatcgaa aaacagcatc gattgaggaa 3830521 gccttagctt gggctgaaga ggcaaagctg gcaggaaaac ctttgtccat tgcacttctc 3830581 ggaaacgcag ctgaggtgca tcacacactt ttgaaccgag gcgtcaaaat tgatattgtg 3830641 acagatcaga catctgccca tgacccttta atcggttatg ttcccgaggg ctattccctt 3830701 gatgaagctg accgtttgcg tcaagacact ccagagcttt acgtgcgcct tgcgaagcaa 3830761 agcatgaaaa aacatgtcga agccatgctg gcctttcagc aaaagggctc tattgtattt 3830821 gactacggca acaatatccg gcaagtcgca aaggatgaag ggctggagaa tgccttcgat 3830881 tttccggggt ttgtccctgc ctacatccgc cccttattct gtgaaggaaa agggccgttc 3830941 cgctgggcgg cgctttccgg agatccggca gatatttacc gtacggatgc gttattaaaa 3831001 gagctgttcc cgacaaataa agcccttcac cgctggattg atatggcaca ggaaaaagtc 3831061 accttccaag gcttgccgtc ccgtatctgc tggcttggat atggagaacg aaaaaagatg 3831121 ggcctcgcca ttaacgagct ggttagaacc ggggagctaa aagcgcctgt cgttattggg 3831181 agagatcatt tggactgcgg gtctgtcgcc tctccaaacc gggaaacaga agcgatgaag 3831241 gatggaagtg acgctgtcgg tgattgggct gtgctaaatg cgcttgtcaa cacggcggcg 3831301 ggtgcaagct gggtttcctt ccaccatggc ggcggcgtcg gaatgggcta ttcccttcat 3831361 gccggcatgg ttgcagtggc cgatggaagt gagctggctg acgagcggct cgcgcgggtc 3831421 ttaacgagcg acccaggaat gggcattatc cgtcatgcgg atgcgggtta tgaacgtgcc 3831481 gttgaagtag cgaaggaaca ggacattatc gtgccgatgc aaaaataaag gagtgatgac 3831541 atgccaaagc aaattgatac gattctcatc aacatcggtc agcttttgac gatggaaagc 3831601 agcggtccgc gggcaggcaa aagcatgcag gatcttcatg tgatcgaaga cgctgttgtc 3831661 ggcatccatg aacagaaaat tgtgttcgcc ggacaaaaag gggctgaagc cggttacgag 3831721 gcagacgaaa tcattgactg ttcgggacgc cttgtaacgc ctggcctcgt tgatccgcac 3831781 acccatcttg tatttggcgg atctcgtgaa aaggagatga accttaagct tcagggcatt 3831841 tcatatttgg atattctggc gcagggcggc gggattctgt ctacagtcaa ggataccagg 3831901 gcggcttcag aagaagagct gctgcaaaaa gcccattttc atctgcaaag aatgctgtcc 3831961 tacggcacaa ccacagcaga agtgaaaagc ggctacggct tggaaaaaga gacagagctc 3832021 aaacagttgc gtgtcgcaaa gaaactgcat gaaagccagc ctgttgacct tgtttccaca 3832081 tttatgggag cccatgcgat tcctcccgaa tatcaaaacg atccagatga ttttctggat 3832141 caaatgcttt cccttttgcc ggaaatcaaa gagcaggagc tcgccagctt tgctgatatt 3832201 tttacagaaa caggcgtttt tacagtcagc caatcccgcc gttatttaca aaaagcagct 3832261 gaggcaggct tcggattaaa aatacacgca gatgaaatcg atccgcttgg aggtgctgaa 3832321 ttagcaggta agctaaaggc cgtctcagcc gaccatttgg taggtacatc ggacgaaggc 3832381 ataaagaaat tggctgaggc aggaacgatc gccgtcctct tgccgggcac gacattttat 3832441 cttggcaaaa gcacatacgc cagggcaaga gctatgattg atgaaggtgt atgtgtcagc 3832501 ttggcaacgg attttaatcc tggcagctcg ccgactgaaa atatccagct gattatgtcc 3832561 attgccgcgc ttcatctgaa aatgactgca gaagaaatat ggcacgcggt cacagtcaat 3832621 gccgcatatg ccataggaaa aggagaagaa gccggtcagc tcaaagctgg ccgctcagct 3832681 gatcttgtca tttggcaagc cccgaactat atgtatattc cgtatcacta cggggtcaat 3832741 catgtacatc aagtcatgaa aaatggaaca attgttgtca acagggaggg agccattctt 3832801 ggataagtac ccttttctca gagaggccgg atcttcgttt aaagaccggg atgtcacaaa 3832861 aatgagcgac ctgatcgcaa catgggacgg ccaggacatt aagggaccgg cgttgatagg 3832921 tgtcccccta tcaaaatcct ccatcagtca ttcaggcgct tcctttgcac ccggaacaat 3832981 acgccaggct ctgaaacatt catcagccta ttctgctgag cttggagagc acgtcgtatc 3833041 agagcttcta tatgacctgg gggatatcga tattcatgtc actgatatcg taaagtcaca 3833101 tcatcacatt ttccaaacca tgcacgctct gctttcggat catccggatt gggtgccgct 3833161 catacttggg ggagataact ctatcagcta ctccacaata aaagcgatag cacaaacaaa 3833221 aggaacgaca gcggtgattc aatttgatgc ccatcacgat gttcgcaata cggaggacgg 3833281 ggggccgaca aacggcaccc ccttccgccg ccttttggat gaagagatca ttgaaggtca 3833341 acatttgatc cagctgggta tcagagaatt cagcaacagc caggcctatg aagcatatgc 3833401 aaaaaaacat aacgtgaaca ttcacacgat ggacatgatc cgggaaaaag gactaatccc 3833461 aacgataaaa gagattttgc ctgttgttca agataaaaca gatttcattt ttatatctgt 3833521 tgacatggat gtcttagacc agtcccatgc acccggctgt ccagcgattg gcccgggcgg 3833581 cctctataca gacgaattgc ttgaagcagt caagtacatc gcacaacagc ccaatgttgc 3833641 cgggattgaa attgttgaag tcgaccctac cctcgatttt cgagatatga caagcagagc 3833701 tgcagctcat gttctgttac acgcattaaa aggaatgaaa ctctccccat tcaagtgatc 3833761 ttctggcagg ttgtattttg ggtataagaa actcatctgc ctaaggaatg gcagctaaaa 3833821 ggagggcgag acagtgaatc ttcaggagaa cagcagccaa cagctaaaac gcacaatgaa 3833881 aagcaggcac ctatttatga tctcattggg aggcgtcata ggcacaggac ttttcctcag 3833941 tacgggctat acgctacatc aagccggacc cggcggtacg atactcgctt atgtaatcgg 3834001 cgggttgatg atgtacctcg tcatgcaatg tctcggcgaa ttgtcggttg ccatgccggt 3834061 gaccggctct tttcaaaaat atgctacaac atttatcggt ccatctaccg gttttatggt 3834121 cggcatcatg tactggatca attgggtggt gacggtaggc tctgagttta ccgcatccgg 3834181 tattctcatg cagcgctggt tccctgacag cagtgtatgg atgtggagtg cgatttttgc 3834241 agcccttctt tttatatgca acgcattttc agttaagtta tttgcggaaa ctgaattttg 3834301 gttttccagc gtaaagattg tcaccattat tttatttatc attttaggag gagccgccat 3834361 gtttggcctg atctctttaa acggaacggc ggatgctcct atgttgtcaa acttcacaga 3834421 tcatggcggg ttgtttccaa atggctttct cgccgttttt atcgcgatga tatctgtgag 3834481 cttcgccttt tccggtacag agttaatcgg cgttacagca ggagaatcag caaatcctca 3834541 aaaggatata ccgcgatcca tccgtaatgt cgcatggaga accgtgattt ttttcattgg 3834601 cgctgtcttc atattatccg ggttgatttc atggaaggac gcaggcgtga ttgaaagccc 3834661 gtttgtcgcc gtatttgcgg agatcggaat tccttacgct gctgatatta tgaatttcgt 3834721 aatattaaca gccttgctgt ctgtcgccaa ctcaggctta tatgcttcga cccgtatgat 3834781 gtggtcttta gcaaatgaaa acatgatcag ctcccgtttt aagaaagtga catctaaagg 3834841 cattccttta aatgccttaa tgatcagtat ggctgtatct tgtttatctc tcgtttccag 3834901 tatcgtggcc cctggaactg tctatgtggt gatggtcgca attgctggat ttgcaggagt 3834961 cgtggtctgg atgagcattg ccttgtccca actcttgttt cgaaagagat ttttgaaaaa 3835021 agggggggat gtaaaagatc tgacatttcg cacgccgctt tatcctctta tgcctatagc 3835081 cgctctctta ttatgttctg cttcttgtat cggtcttgct tttgatccca atcaaagaat 3835141 cgcacttttc tgcggagttc cttgtatcat cctttgctat ctcatctacc atttcaaaag 3835201 aaatgttaca aaagcgaaaa aaatcagcca agaggaatat ccagccgatc acatcctata 3835261 attaaaaaag cacaccccgc tcagcatggg atgtgcttta ttttttattc tgtaattaac 3835321 gtatgaatca gcttcggcgc cttcgcttcc gcggcgatgc ggatgttgtc atagactttt 3835381 gcgatgactt catcgacgtt ttctcggtta gcgtaaagcg ttacgagcgg ttcccctttt 3835441 tctactttgt cgccgacctt tttgcggagc atgatgccga cggctaaatc gatttcgtct 3835501 tcttttgtgg cgcggccggc acctaacagc atcgccgcga cgccgatttc gtccgcgacg 3835561 atttcagaga cgacacccgc ttctttggca ggcacatcaa tttgatatgc ggcttgcgga 3835621 agcttagacg gatcgtcaac aattgagctg tcgccgcctt ggtttttcag gaaatccttg 3835681 aatttctcaa gtgctttgcc gtttttcatg acttcttcca gcttcgctct cgcttcgtcc 3835741 aatgtatcgg cttttttcgc aagcacaacc atctggctgc cgagcgttaa gacaagctca 3835801 tgaagatcct caggcccctc gcctttgagc gtgtcgatcg cttctttgac ttcaagcgca 3835861 tttccgatcg caaagccgag tggctgggac atgtctgaaa tgacagccat tgtttgacgg 3835921 ccgacgttat ttccgatgcg taccatcgct ttggcaagtt cagctgcgtc ttcttctgtt 3835981 ttcatgaagg cgcccgctcc cgtttttacg tcaagcacga tggcgtccgc cccggcagcg 3836041 atttttttgc tcataatcga gcttgcaatg agcggaatgg aattgaccgt tcccgttaca 3836101 tcacgaagcg cgtacagttt tttatcagcc ggcgttaaat tgccgctttg gccgatgacc 3836161 gcaaccttgt cgcggttcac aagtttaata aattcatcct tcgtcagttc cacgtggaag 3836221 cccatgattg cctctaactt atcaatcgtg ccgcccgtat ggccgaggcc gcggccggac 3836281 atcttagcaa ccggcacatc aagagccgca acaagcggag cgagaacgag cgttgtcgtg 3836341 tcgccgacgc cgccggtaga gtgtttatcc actttaattc cttcaatggc agaaagatca 3836401 atcgtttcac cggagttcac catagccatc gtcaagtccg cgcgttcacg gtcactcata 3836461 tcctggaaga aaatcgccat agcaagcgcg cttgcctgat aatcaggaat gcttccatct 3836521 gtatagccgt tcacaaaaaa ttgaatttct tcagtggtga gttcttttcc gttttgtttt 3836581 ttgatgatga tatctaccat tctcatgttt ggtcaccgat ccttttcgat taagttcagt 3836641 aaatcaagcc cacaattgct gctgataaaa agctgacaag cgtagcaccg tataataatt 3836701 tcaagccgaa acgagcgacg acatttcctt gcttttcatt cagtcctttt acggcaccgg 3836761 caatgattcc gattgaggag aagttcgcaa atgacacaag gaataccgat acgatcgctg 3836821 ttgtacggcc gctgaaatgg aaaccgtttt gcgtaagcga cgtcatggcg acaaattcat 3836881 tcgataccat ttttgttgcc ataatgcttc ccgcattaac agcttcattc catgggatac 3836941 cgacaagaaa agcgaatgga gcaaacacat atccaagaat gccttggaac gaaataccga 3837001 atactgcatt aaaaatgcca ttgatcaatg caataatcgc gacaaatcca atcagcatcg 3837061 cagcgacgac aaccgctact ttgaaaccgt caagaatgta ttctccgagc acttcgaaga 3837121 aggattgttt ttcttcttcc tcaacacgaa gcatatcctc ttcttttgca acctcgtacg 3837181 gattgataat agaagcgata atgaaaccgc caaataagtt caaaacaagc gctgttacaa 3837241 catattccgg tttcagcatt gtcatatacg caccgacaat cgacattgat acagttgaca 3837301 tcgcagatgc gcaaagcgtg tacaagcgct gctgatttaa aagaccgagt tctttcttca 3837361 aggagataaa tacttctgac tgccctaaaa tcgcagaagc cactgcgtta tacgattcca 3837421 atcttcccat accgtttacc ttgctgaggg caaggccgat atatctaatg ataaacggga 3837481 ggactttcca cttttgcaga atcccgatca gagcggaaat aaacacgatt ggcaagagaa 3837541 cattcataaa gaatgtcgtt tggtccgcat tcaccaagcc gccaaacaca aagttaattc 3837601 cctctgccgc gtattcaagc aggtaaccga atccttttgc aaatcctccc acgaggaaat 3837661 tccctattcc ggtattgagg agaatgtagc caagaataaa ttgcaaaatg agcataacaa 3837721 caattgggcg gatcttaatt ctttttttgc cgctgctcgc gatccacgcg aggcctaaaa 3837781 acacgattaa accgataatc ccaatcaaat acttcatatg tgtttctcct ttatttgtat 3837841 tcgcttacaa ttactgtttc ctcagaaaac ggaaagcagt ctgccttccg tcagctctta 3837901 atagttgtct ccgcctgatg cattttctcc ttttacgata gaaacgcctg cgctggcgcc 3837961 aattcggctt gctccggcct ctaccattgt gtctacatct tctttcgttc tgacgccgcc 3838021 agatgctttc acgccgatat caggccctac tgttttgcgc attaaggcga tatcttcctt 3838081 cgttgcgccg cctgtagaaa agcctgttga tgtttttacg aaatccgctc ccgcagacac 3838141 cgctaaacgg catgcacgtt ctttttcttc atcagtcaga aggcacgttt cgataatgac 3838201 tttgacaagc gcttttccgg ctacagcttc cactacaccg cggatatcag cttccaccac 3838261 atcgtcttcc ttgtctttta aagcggcaat attaatgacc atatccactt cagtggcgcc 3838321 ttttgaaatg gcgtcttttg tttcgaacgc ttttgtttca gttgtattgg caccgagcgg 3838381 gaagccgatg accgtacaaa cgtcgactcc agttccctta agctcttttg cagcaagctc 3838441 cacccatgtc ggattgacac atactgaagc aaatttgtat gttttcgctt cttcaattag 3838501 ttttagaatg tccgcttttt gtgtatgcgg tttcaaagct gtatgatcaa ttatgttggc 3838561 taatgacatc cttcgcacac ttcctttttt gttaagatat tttttagcat aaccgacttt 3838621 tgaacatatg taaattggta attgaaattt tgttcaatga aaggtttgaa cgtgtcacaa 3838681 atcattaaca agcgccctcg cggtatgctg gtcaatgatt aaaacgttgg catattttcc 3838741 ggttaatgct ccgtgaatgg aagatacttt tctgcttccg ccggcaacta aaatggagcg 3838801 ttccttcagt ctaaggtctt gaagctcaac accgatggtc cggtcattga tggcgctgct 3838861 gcaaatattc cctttcgcat caaaaaagcg tgaacaaata tccccgacgg cctgtttttt 3838921 cagcagggct ttctcttctt cgttaaaata tccgagccga aacaacagcg cttcatcacg 3838981 gacagtcccg accgtaaaga gagcgatatt cgcctgcttg cccatctcaa tgatccgttc 3839041 aatatgacgg tctttctcca ccattcgctt cacatccgca ttatcaaaca cgacgggaag 3839101 cgggagatag cgcggcatcg tttgaaaagc ctctgcaaac agctgaatcg tttcagccga 3839161 atacgtgttt acccgggaat ggctgatgcc gcctttcagc tggacgacct cgacgccttt 3839221 tacctgcttc ggctgcatgt tttgcgcgat ttgatacatg gtggttcccc agctgacgcc 3839281 gacaatgtcg ccgtctttta ccgtttcatg catatattct gcaccatagc ggcttaggtc 3839341 atgtgtaatt cctgcataat cgggtgtcgg ggaaaacaca acatgcgcct caaggagccc 3839401 gtatttctct tcaagtatgg aaccgagcgc atccaaatcc tcaaaagggt ccatgacgcg 3839461 aatctggaca tacccttttt cctttgcata ttgcagcagc cgggaaacgg ttggccttga 3839521 aatgttgagc tgctcagcaa tttgctgctg actgtagtca gactgatagt aaagccttgc 3839581 cgcttctatg cttaattgct gtttttcccg atccattctg cacctccctg tggatcagtc 3839641 ctgataaaac tgcttttgat ttgcttttat tatacaggct ggcgccggct ttcatccacc 3839701 tgatttctaa gaaactgaaa aacgctctgg gcgcggacct gcccagagct tacttctccc 3839761 aagtcatatg ctgataaatg cctttcataa tggcgtacat tccatatagg atcaggccta 3839821 atgccaatat agacagaatc aatttgccat gcggctgctg cgcgagttct gcgagcgcgc 3839881 cgtcaaagcc tcttgtgtcg tcgggatcag cggtcatggc tgtcttgatg agaaaatagc 3839941 cgatagccga gaaaataatg gcccgggcga tattgcctgc gcgtcctgtg tttttcgtga 3840001 tgcatatcat ctgtttgttc atttttgatg tatcgaattc tttcataaaa gcagcccgaa 3840061 cgcctttcat aaattgaaca atcgcaaata cgataaaacc cgcacccgta agccctgtga 3840121 gccattggcc gaacggctgc gccaatacat aagcggacca cgtctgttct gaagtgccgc 3840181 cgtccccttg gccaaacaca aatcgcaagg cattccaagc gatggatgtg taaacagcgg 3840241 cactgaaaaa gtttcctatt ctccgcgaca ggcctcgcct gctgtttccg tgcccctccg 3840301 tgtccttgat cgcgcttaac accatccaga tcacatagcc gataaggccg atgcctataa 3840361 aaaaaagcaa tagtgaccca tacggcatgc gtgatagcgt ttggagagct ccgctcgaat 3840421 ctttggcgcg gcctgccccg gcagccgtca taaaagccaa aaccccaagc agaataaaaa 3840481 cgccgccgaa tgcaaaataa ccaagcctcc cgaatcgttt gatccaaggc ttggtttcct 3840541 gttttatttt tgacatgtac cggtctttca ccgccatgtg tccaaccctc tttcacagaa 3840601 atctttactg taacattccc gattgaacaa agttgaaaca gctcctgcct cagctatggc 3840661 tggctgagat acgtttttgc tgtttagctg attgtgcagg tgtcatccaa gcagccgctg 3840721 cggcagctgt gactccgcct gctaatttcc caatgatcat ggccgccgcc atttcttttt 3840781 tcattccagc tacaaaaccg agatggctgc cgagtacaaa ggcgccgctg accgcaaacg 3840841 cgacattgat gacctttcct ctcggcgtca tatcctttaa tgaagccagc attgggatat 3840901 gatgcgccaa agaggtcact aagcctgctg ttgctgtctc atctaaatga aggcatttcc 3840961 ccagagcctg aagcggtttt ttaaaggttt ttgtaataaa tgccgtcatc gggaacgccc 3841021 ctgccagagc aatggcgatg gtccctgtcg tttgtatccc tgtctcgaca ttctccattc 3841081 ccggaatcag cacaatgccg gtcatcgttt caacagaaac agctgcaagc ccgataatcg 3841141 caaccatact gaccgctttc ccgaagagat gaaacaactg aatcattctg tcggtgtatc 3841201 gccataaccc aaaagcgatg acagcagata acagactcgg gatcagaaga tttttaccta 3841261 tcatgccgat gtcaaagcct gcgcataatc cgccgattaa gcaaccgatc ggcactgtgc 3841321 acagcccgat taatatgcct ttcgcaaaat acggatgatc ctctttttcg atgatgccaa 3841381 gagcgacggg aatcgtgaag acgattgccg gccccatcat tgttcctaaa aacacccatg 3841441 aaaacagccc ggcctgcgga tctttcgcca tttctccagc cagcgcatat cctcccatat 3841501 caatcgccaa aatggtgttc gcaaaggaag aaggatccgc gccaatcgct gtgtaaaacg 3841561 gagcaacaat gggaatcaag attgctgcca gcacgggcgc cagcgataca attccgatca 3841621 tggacagcgc cagcggcccc atagccttaa agccgtccgc aaaccgctcg cctagccccc 3841681 atctgtttcc caaacaataa tccgctgctc cccatagtaa aaaggcagcc aaaatgaata 3841741 caaccgcgtc attcaccgtc atggttttct cctttttcaa acgtatgatt ggttttatca 3841801 tatcatctga aatcaccgaa tagagttgat cttattcaat atgagctaaa aattctttta 3841861 tatcggcttt ttcaacggct gttataatgc gtcgcgcttt ttcttgcggg accgttaatg 3841921 tcaatttttc tattatgtct tcttcagaca gctcatttcc tggtgcccct tttgggcagt 3841981 ccacacgcgc ttcgcaaatc cggccgtctg ataaataggc ccggacaatc gtgaaacggc 3842041 cttttggaac ggcatgagga gccggctgaa tagcattgtc atatacgcgc tgaattcgcc 3842101 ccattgtcgt ttgaaccccg tttgggatcg gctggctgct gaaatgttca acggtcaggc 3842161 cgtgtccatg caaagcaaga gcaatcacat attcaacgct gaaacggcct tcctctccag 3842221 cttttggaga tctttccgtc aatgcagcat ctccgcctgg cggaaatatc acttcaatac 3842281 gttcggtatt ggcagcagaa atggtttctt cggagataag ctgtcgtacc gcatctgcag 3842341 catggtgtgc cgcggaacaa aatggataga ttttaaacca tagacccggc tgcacaattc 3842401 tccacggtgc cccccaatcg tttagcaaag tgtgttgtgc tttctcaacg tcaccgtaca 3842461 gactgaagaa accagtttct ccatcaagtg ccgtgcggga cccgccaaat tctgattggg 3842521 ccagcttaac ggccagcaag ccagcctgag ccgccaaacc ggcgtgcagc ggtttcattt 3842581 ctgttccaaa ttgcaccctc atcccagcag attgcgtagc cgcaaaacca attgcttttt 3842641 ccaactcttc ctgagtcagc tcctcagcat aacctacggc gcaggcagca gcgatggcac 3842701 caagcgtacc tgtattatgc cagcccttct catagtggcg gctgccaatt gattctccca 3842761 gccgtgccat cacttcaaca ccaacaacat aagcgccaag aagccgctcg tcatgtccgc 3842821 gagcggcaga agcaataagg gccggtacga tgactgcact ggggtgtcct cttacatcgg 3842881 agtggacatc atcaaaatcc aatgcatggg cgataaatcc attgagcatc gcggattgta 3842941 atggcgcggc ctttttgccc tgtccgataa caggaacaag gggccggcct ccttcatcct 3843001 ctatcagacg gaggagcttt tgaattcctt tatcttctct tcctgcgaat gaagcggcag 3843061 taaaatcaag taatcccttt tttgcttcgt gaatcgcgtc aactgaatgc tcaggttgtg 3843121 acgttctcac agcctctgca agacctgctg tcagcccttg tttgctcatt tgatggtctc 3843181 caatacaata accgccagct ccgcaaagta ttgagaggca accgtaaggg cttcttcatc 3843241 cagtgtaaag gccggatgat gccactcctc cgtcccgttc gttcccatcc agacaaaaaa 3843301 tcccggaatc ttctcttgat acagagcgaa gtcttctccg cccggagact gctcagcgtg 3843361 aacggtttga tagccaagcc gtgccgcagc ttcggatgcc gcattcaaaa atgtgccgtc 3843421 attctgaacg gaaggcaaat aaggaaacca cttgaattct gcttgtgccc catagcccgc 3843481 tgcaattcct tcagccactc gtctcatatg ctcgggaaca gcctgcctcg cttctttttg 3843541 aaaggttcga accgtcccct ccatttcagc ttggtctgga attacgttcc acgaggtgcc 3843601 cgcctgtact cttgtgatac tgacgactgc gttttgcagt gagctgatat tgcggctgac 3843661 cacagattgc agcccgctga tgatttgtcc ggctgcagcg attggatcaa tactgttatt 3843721 tgggatgccg gcgtgcccgc ctttcccttt gatgacgatc tcaaatcggt caacacttgc 3843781 catgagcgga ccttccttta caccaatggt cccgacaggc agatccggct tattgtgcat 3843841 gccgaaaatc gcagaaacgc cattaagtac gccagcttct agaacctttc ttgctcctgc 3843901 ggcaatttct tcggccggct gaaagataaa gcggactgta cctttcagct cggcccttct 3843961 ttgattcagc aacatcgctg tgccaataat agaagcagta tgaaaatcgt gtccgcacgc 3844021 atgcattgtg ccatcaacct tagatgcaaa tggaagattc gtctgttctt ggatcgggag 3844081 cgcgtcaatg tccgctcgta ttgctatcac ggggccgtct tcccgtcctt tgatttctgc 3844141 aatcacacca gtcttcaatt gagggacatc aagtatttcg atttgctcct cctcaagcca 3844201 acggcggatt tttttcgtcg tttcaacctc ttgaaatgac agttcaggat gttcatgaag 3844261 atcacgccgc atattgatta aacgggtatg aaacgctttg tcggccattg ttcttctccc 3844321 cttcttatat aagctctgca ggctctccca cctgcttgat aaatcgtttc gtccgttcgt 3844381 ttttcggatg gtcaaacagt tcctctggcg ttccctgctc gataatatgg ccgtctgcca 3844441 taaaaatcac ttgatcagca acctcttttg caaacgccat ttcgtgtgta acaatgatca 3844501 tcgttgtttg tttttccgca atggacttga tgacctgaag cacccctgtg acgagctcag 3844561 ggtcaagcgc tgacgttggt tcatccagca aaatcgcatg cggattgacc gcaagcgccc 3844621 gcgcaatgcc gattcgctgc tgctggccgc cggacattgt gattggatag ctgtcagcct 3844681 tatgctccag accgacttgt ttcagaatct ccattccaat acgtttcgct tcgtcgcgtg 3844741 gtttatgttg agccacgatt aaagcttctg taatgttttg cagagccgtt ttatttttaa 3844801 acagattgta gttttgaaag accatggccg tttgctggcg aagccgatgt gcttccttgc 3844861 gtgtaaactt ttccgcattc agtttggctt ctccgatttc aataaggcct tgatccggac 3844921 gctctaatag atttaagcac cggagaagcg ttgattttcc ggaaccggac ggaccgatga 3844981 ttgccaccac ttctccgcgt ttcacttcta gatcgattcc gtcgagcacg acgagatctt 3845041 taaacgcttt gcgaatattt tttactgtta tcaactgatt tcacctctaa gtccggtatg 3845101 gcttgctcat ggcacgttca aacaagtcct gcaaaatgct gtagataatg gtaagaaccc 3845161 aatagacgat cgcaaccgcc aaatacgtct caaaatattt gaggtttcct gaagcgtaca 3845221 tcttcccttg ggcgaacatc tccatgaccc ctaatgtaaa ggccagtgac gtttctttca 3845281 ggagcccgat aaatgtattg cccgttgccg gaatcgcatt tcggatcgct tgcggcaaaa 3845341 taatccgtct gtatgcctga aattttgtca taccgacaga caggcacgcc tccagctgcc 3845401 cgtcatcaac agaattgagg gcggcccgga agatttctgc caaataagct gcgtttttta 3845461 agcttaaccc gatgatggca gctgtgagag ctgtcatttt gctcatctct ggaaatagct 3845521 gcggcagccc gtaatagatt aagaacagct gtacaagtgt cggcacgcct cggaaaaagg 3845581 atatatacag ctttgacagc tgatgaagca ctggaatttt gttttttgta atgagtgcga 3845641 gaataagtcc tccgataatg gcaaaaatca tagctgctat tgccataaac aaggtgatcg 3845701 gaagggcctg aattaaagtc gggaacgctg atatcatgaa ttcccaatca atcgtgttca 3845761 ttctggtgag tcaccgccgt ttcttaatgc ttctgttcta ctgtgatatc ttcattaaag 3845821 tatttttcag agagtttttt cagtgttccg tctttacgca attcatctag ggccttattg 3845881 acttttttgc ggagcttgtc gtgcgcatcg tccttggcaa atgggaatgc aacctgttcg 3845941 taaacaatcg gatctcctgc aagctttaat ggcaaaccgg tcttcttgat ttgcgcgatc 3846001 aatacagttc ggctgttgac ataagcgtct acacggccgt acgcaacatc cttcagcgta 3846061 ccctcttgtg tttcgtacgt tttgatattg atttttttat caggatcttt gctttcaagg 3846121 tttttcgcgt ggtttgaacc gagaacggct gcgactgtct tgccttttaa atcgtctact 3846181 gatttgatgt ctgtattgtc ttttttgacg acaatctgtg ttcccgcata agcgtatggt 3846241 ttcgtaaagt tatacgtttc cttacgttcg tctgtcacag ctacctggtt ggaaatggtg 3846301 tcaagcttgc ctgtttgaag ctctcccatc agcccgctga attcaagcag cttccagtcc 3846361 agtttcatgt caattttctt agcgactgct tccatcactt ccacgtcaaa gcctgtcagc 3846421 tttccgtttt ctttataagc aaatgggtaa ctttgtcctg tcgcaccgac atgaagcaca 3846481 ttgtcatcct ctttactgct gctgtttcca ttgccgcaag ctgagagcac cgctaataat 3846541 gcagcaacga ccagcactgt ccattttttc atcttcattt gattttcccg ccttttctat 3846601 ttttatagat catgtcgcaa ttgttttttc atatagactg tgatatgccc ttttccaagg 3846661 tcttgttcac ctgagcggac atatcctttt cgttcgtaca tctcaatcag ccacggatgc 3846721 ttatccgctg ttccgagtga gacaaacgga acctttaacg tatcgcgaag gattgtttcc 3846781 tccagccatt gaagcagctt tgttccgatt ccttttttac cggtgtcggg gtccacagca 3846841 aaccaccaga tatgcggaac gccatacggt cccggctgtt ttccccaagg cattctcaag 3846901 gtgatggtcg cgatgatccg cccgtcttct tccatgacgt agcaagcatt ttcccgaata 3846961 tttttcagca ccaaatccaa atccgcatga gcagcagcaa aacgaatgcc gagctttcga 3847021 atcggttcat aagcccgcaa tgtcagctcg agaagctgtt cggcatcacg ttcaactgca 3847081 aggcggtatc gtggcttcat ctagcgttcc tccttacttt gcatagcggt ttaccggctt 3847141 ttccaaaccg aagtgctctc gtaatgttgt gccttcatat tcttttctga acacgccgcg 3847201 ctcctgtaaa atcggaacca cttgatcaac aaacacttca attccttctg gaagaagcgg 3847261 aggcatgatg ttaaacccgt cacacgcttt cgtatccacc cattcctgca tcttgtcggc 3847321 gagctgctcc ggcgtgccga cgaagatatg gtggcctctg gagcctgcaa cgtatttgta 3847381 aagctctcgt atcgtcatat tgtcacgttc agccatctcc tgaacaagct tgaagcggct 3847441 cttcaccgca ttggaagctt cggcgtcaag cttcggcagc ggcccatcaa gcggatatgc 3847501 cgacaaatca attccgccta agtaattttg gagaatttgc agaccgacag atgggataat 3847561 cagatcttgg agctccttgt atttggcttg cgctgcttct tctgtatcgg caatgattgg 3847621 gaaaataccc ggcataatgg caattttttc tggatcacgt ccgaattccg cagcctgttc 3847681 tttaatggat tgataaaatt cttgagctga ttccaggtgg ttttgtgctg tgaagatcac 3847741 ttcggctgtt ttggcagcca gcgcttttcc gtctcctgat gatcctgcct ggataatgac 3847801 cggctggccc tgcggggttc ttgaaacgtt tagaggtccg cgaaccgaga aatattctcc 3847861 tttgtggttc agctcatgca ttttttcttt gtcaaagaat tcacccgttt ctttattacg 3847921 gataaaggcg tcctcttccc atgaatccca aagccccttt acaatctcga caaattcctc 3847981 tgcccgctga tagcgcaaat ggtgttcaag gtgcttttca ccgctgaaat tcagcgctgt 3848041 tgattcaata gatgaagtga cgacgttcca tccggcacgg ccattggaca gatgatccaa 3848101 tgacgcaaac tgtctggcaa tatggaatgg ctcgctgtat gtagtggagg ctgttgctgt 3848161 cagtccgatt tttgatgtga cctgcgccaa agcagagagc agggtgaatg gctcaaacct 3848221 tgttaataca tttggatgtg atttgctgtc aattgaaagg ctgtccgcta aaaacagcat 3848281 atccagcttg cctcgctccg ctgttttcgc aagctcttta aaataatcca aattcatgct 3848341 cgcatctgac ggcgcgtccg ggtgccgcca agacgcaaca tgatggcctg tacctgctaa 3848401 aaatacccct aatttgattt gtttcttttt gcttgtcatg gcgatactcc ttttatcatg 3848461 tttttaggct gaataatccg aaaaataaac tcctatattc ctagtcgttt aatatgaata 3848521 aatcaaaatg tacctttgtc ttggacgttt gtcaatgagt taagattaat tttttctatt 3848581 caagcgaaaa gacccttgcg tgaccatgag ggaacggcat tgattcattc aactagtgca 3848641 acctctatat cggcaagaaa actgagtcta atgaagcaaa gactcagttt tcttccaata 3848701 atttcatata agatttcgcc atttcctttg ccttttcttc gcttttgcaa accgcctatc 3848761 cattcagacg ccgtaacgat tgtataaaaa aacagctgac tccagatatt caaaccggaa 3848821 tcagctgatt gatgtgaatt aattaagctc atgaatactc tcttctgctt tagcggaaaa 3848881 cactttaggc tccaaacagt caaggtcttc atgaaataaa tttacttttt ggatttgccg 3848941 attgtcatag tggtggaaat agtagtttcc agtttcgttg cacatcacgg aagtatattg 3849001 cgtataatga atttcgtctt cttccgttat cactgcgccc tttggtatcg tcatatttgc 3849061 caaaatttga aaagcggctg ttacaccttt cgtttcatcg gccgccggct ctagatgttc 3849121 tttcaaataa acagctctga caaaccggga aggcggtgta taatcccccg gcagaccaac 3849181 agttcctaag ccttggccaa aagcagaaag ggctaatccg cccatctctt tgctctctaa 3849241 ttgcttcggt ctgattcctg tatattgctg cagattggtt acatgccata taaagtcggg 3849301 gctgttcgtc atgacaccag gttgattatc atagactttg aggccgtctg ctcttggttc 3849361 tatcgtcagg tttcggcccg tccggtctga caatatccag tgaagcggta aaactgtatc 3849421 caatagatct aattttttct ctacaatcgt taaagatcga atcttttctt ttacgtcttc 3849481 caaagactga cagactgaca gcacccatgt cacaaactca tgcgggacaa tgtgaacggt 3849541 atcttcccgt atcgtttttt cgtactccgc atagcccgga aaataaagcg ccgcacaaga 3849601 taaaccgctt tcattaatgc cgtcggcaaa taatatattt ccaagttttc tccccatacc 3849661 gataaacgcg tactgtgtct gatgggccct tccgtcagct tcactgttcc agctgtaacg 3849721 gcgcggatag agaatcacct ctgtccccag ctgaaatgca aaatccattg ttcttgctaa 3849781 tacatgttta cggtcagcag tttccaatgt aagacttgtg cacatttgat cagtcccctt 3849841 ttcaattcag attaatatca tacatattgt gaacgaattg gttttatcag cataacgaaa 3849901 gtcaaatcga ttcgtcaaag aattgacatt acatcaaata aaacgaaaaa atccagcctt 3849961 tagaaggctg gattttttat tatttagcca aaacaagctc gtgaatcgca tgtgcaacgc 3850021 catgttcatt attggagcgt gtttgaaagt ttgctgcttc caatacttct gggatggcgt 3850081 ttgccatggc aaccccgcag cccgcccatt cgatcattgt caggtcgttc ccgttgtcgc 3850141 ctatgcacat gacttccgcc tgttcaattc caagcagctg agccagctgg cgtacagcat 3850201 ttcctttgct ggcttccgag tgcagaattt cataaaagaa aggcgcgctt ctgaccattg 3850261 tatatttttc tctcacgtct tttggaatcg atgtaatgac gcggcttaag ttctccggtt 3850321 tatcaataaa catcactttc gggatgagga tatcttttgg cacctcgtca atcttgcgga 3850381 aatgaagcgg cacctgtgtc acataggatt cgtatacggt aaattcgcta atatcccggt 3850441 taggcgtata caaattagat gagtcaaaga aatgcatcgg cgtcttcagc tctaagctca 3850501 ggtcatataa tgaagtcaaa tcatcataac cgagagacag ctctgagacc acttcatttg 3850561 tatgcgtatt ttgaacaagt gctccattat acgcaataac atagtcgcct tcttcaatta 3850621 aattcagttc atctaaatat ctctgcacac ccccgatagg ccggccggtg caaagcacaa 3850681 ttttgacacc ttccgctttt gccgcgtgaa gggcgtcgcg gacctcctct gttacttcat 3850741 gatgatcatt taaaagtgtt ccatccatat caattgcaat tagtttgtac atcctgcatc 3850801 tccttcatgt cgttttcagg ctatagtccc atcatatcgt tttttctttt tgatattcaa 3850861 ccggaagaga tggttttctc cggattctgt ttagacgccg cccttgtctt cggatacgca 3850921 agcgcggttt ccgctttctt tctgccttga cgccgttttc tgcttttttc tgtttcatca 3850981 gcagaaagcc ggcagctaga aaaggaatgc cggttatatt caagatggca agcttcacac 3851041 ccgccgcgat gaaaaagaac ccccatgaag atgatggatt ccgtctgatc atgacgtaag 3851101 ccgccatttc cagaacgatc aggatggcat gaagcactat gccataaatc agcaatacaa 3851161 gggcaaaaaa caaaacataa ttcacgattg cccctgagta catcatagcg cgcatcattt 3851221 gtataaacga taaggactgc atggagccgc tgatgacatt agggttatag atcgtatagt 3851281 cactaaataa atgtttgact ttgagaaaag cccataatat aaatatccat tgaatgatat 3851341 gtaaaacaag ccccgctgcc accagtcttt cagctttttg atttctcatc tttctcctcc 3851401 ctgccggtct ttgattcgat tcttgtcatc gtttttctct gtccattttg ctcccatatc 3851461 aatgtcccgt tttctcctct tttcagcgtg cttttgagcg gataataagg gccgaggtac 3851521 tgaatctcga tagacccgtc agtgctttgg gaaatcacct tgtatgccat aaaaggcagc 3851581 tgtacctctc ctcttccttc catcacttcc gtttccacaa cctcgtcttc ggtaaatgtg 3851641 actgttgctg atttcacacc gtccgttggc ccgggggcac gcccctcatc ccacgttccg 3851701 taataaaacg gcgtctcttc tttttgctgc tggcagcccg ataccatgat gcatacagca 3851761 attaaaaaca aaatgccata tttgtttctc aaggggatca ccattctttc ctcctttttt 3851821 gggcgaatgc cgtgccactg tgccaatgac tacataagtt ataaggaatt cacccacaag 3851881 gagactgatc acatgaaccc ttatcaatat tacagccctc agctgcctca gcaggaacct 3851941 tactatagcc actatgagta caatccttat ccgcagcagg atgtatacga tccataccaa 3852001 atggacagac agccggcatt ggaaagaaga atcgcagcac ttgaacggca aaatgaacag 3852061 cagtcaagag aattaacccg tctgacaaac gaagaccgcc gtcaaaatcg ggaaattgca 3852121 cggattgccg aacaggtcaa tcagttaagc caggctgttg aacgccatac acgccgccta 3852181 aatcggctca atcagcgcct ccgtacagta gaaaaccggc tgaatatccc atttactgca 3852241 ggggaaggcg gtttctgagc gaaacaaaga aaaaaagcgg aatacgattc tcccatctca 3852301 gggtttcgtt ttccgcattt cttatatgtt aaaacggaac atttacataa aaagggtttg 3852361 tacccagtat acaatcttta ccgttttcat tcaaagatag aggggctgag gaaaataatt 3852421 gtagttcctc tttgacggaa tttcttttca ttcaagttgc atgataatac cgactcacgt 3852481 caatcgatac atggagggat cattcatgca taatacacaa cacggcttgc agcagctgaa 3852541 ccaatgccgc caaactgctc agcagctcat tcagcaaaca cagcaaagca gccagcaata 3852601 tcgccaaatg cttcatcagg aacagcaaaa catccaaatg ctgcagcaga ttctaaacca 3852661 cgaacaacaa gctgcacata ccattcagca agcactgcac gggcatgaca tggcgattca 3852721 aaagtgccag caggttgtca acatgtgcaa ccaaatgcaa caggaactta ctggacaatc 3852781 cagcgtcatg aatacgaatg tgtctacact tccattcggc caaaacacga catttcagca 3852841 gcaatcctac cagcagtaac atataaaaag ctcaacacaa tgcgagtgtt gagctttttt 3852901 tcttactgtt ctttgcgaat atgtatatcc tgaatagact gtttcggtgc atgaaatctg 3852961 ctctcggctt cacttcttgc ctcggcaaaa gcccgcgcct ccacatgatc tttgtagaca 3853021 tccagctgaa tcaaatacag cgggcgcact ttaaatccat gaataatggt taccgcccat 3853081 aacgggacca caataaaaac accgggcaga tcgggcaaaa caaaaccaaa cgcaaaaatg 3853141 aaaaaataaa tgatgccgta catgatccac tttctatttc taaccttgat gccaataaat 3853201 aaaaaggcaa aaaaactggt aatggcaaaa ggcatgaaaa taaacagcat ccaccagcta 3853261 tgcagccatt cccaagcggc acctcttttt gtaattccca tatttttctc ctcctattta 3853321 cctataataa tcgattaggc acaccgcgtc acccataaac gggaaaaact ttctccctta 3853381 aaaatagtga tagacggaga acaggtttct tgctatatta ttaattgata atgataatca 3853441 ttactaatct attgagatac atagtgggag ggttcttgat gaaaaagaac atattgctcg 3853501 tgggcatgct tgtgctgctt ctcatgtttg tcagcgcttg cagcggcacg gcttctaaag 3853561 ggagctcaag cgattctgct tccgaaaaaa cagaaatgag aacatacaaa tcaccaaaag 3853621 ggaacgtcaa cattcctgca catccgaaac gcatcgtcac tgatttttat gccggtgaat 3853681 tgctgtctgt cggggccaat gtggtcggct caggctcatg gtcatttgat aatccgtttt 3853741 taaaatcaaa gctgaaaaat gtgaaggatg ttggtgatcc aataagcgtt gaaaaagtga 3853801 tggagcttca gcctgactta attgttgtca tgaatgaaga gaatgttgat aaattaaaga 3853861 aaatcgctcc gactgttgtc ataccttata acacagcgaa aaacgtagaa gacacagtca 3853921 gcatgttcgg agatatcgcc ggagcgaaag accaagcaaa atcctttatg gctgacttta 3853981 acaaaaaagc ggaagcagct aagaagaaaa ttgccggcgt catcgacaaa gatgcaacct 3854041 tcggcattta tgaaaacaca gacaagggcg aattctgggt gttcaatgac aatggcggac 3854101 gcggcggcca agctgtatac aatgcacttg ggttaaaagc gcctgaaaaa attgagcaag 3854161 atgtcatcaa aaaaggagag atgaaacagc tctctcaaga ggttattcct gagtatgccg 3854221 cagattatat gttcattacg gattacaacc cgaaaggcga aagcaaaaca ctcgacaagc 3854281 tggagaattc ctccatttgg aaaaatcttg acgctgttaa acataatcgc gtgtttatca 3854341 atgactttga ctcgttctac ccgtacgacc cgatttctgt cagcaaacag gtggatatca 3854401 tcaccgacat gctgatcaaa cgggccgaag aaaataaaaa ataaaaaaac ggcacagtca 3854461 tgacgctgtg ccgtttttta tgattcactt taattttgac tgtacggagt ccggcatatc 3854521 ttcaaacttg acttcttccc aagtctcgac atactttcct ttcgccttca ccttcaaata 3854581 cgcgttcttc cgaagctctt tgccggcgaa aaaggtcact tcttcttttt tcccggatgc 3854641 attatatccg tctaatgtat attcagtacc gcccggacta agatgtctgc catctcgatc 3854701 aatctgaaca tagacatctt gctggtgaat aaacggatta aatctgtctg taacatcgtt 3854761 atgaaaaaag agaagcccgc atattacggc agcagccgcc aagacggcca ggattgccat 3854821 tgcttttttc atctttgcac tccccttact tgttcatttt tttcaaatag cttgaccgca 3854881 ccgcgaggaa gaatagaagc tgaaaaatga aaaaccctcc gatggtgaga ctgagcggcc 3854941 ccgctacatc ggaatatcct tccacagcca atgttctcaa ggcaaacagt gtatgcatga 3855001 cggcaatgac aaatggaaag aagaaaagaa tcgccaattg tattgtcacg ctttgcgcca 3855061 tttctcgctc actcaggccg attttggcca gtgaacggta gcgctcccgg tcttcatcta 3855121 aatcagtgaa cagcctgaaa tataagaaac ttgctgccgc gacaaagaat acaattgcga 3855181 taaacaggcc gataaataga ctcaggctcg gcagctgcac cgtatcatag taagtccccg 3855241 cttttgaagc aaaatcagaa tgcacgtcga tataattgcc gtaaatctca ttttgcaagg 3855301 attggctgat ctcaagactg tctttccaat gatcatagct gtagccgtat aatgacgctt 3855361 tatcaccgag tgatttcagc tgatcaaagg tttgatcatt caccgcgatg atagcattca 3855421 atgagatcag cggttttttg acttctttta ccgacagttt ttgatcagac agctcccctt 3855481 tttggttcag cagcttcagc tgatccggcg cttcgttttt gaaattgcgg tcatacgttc 3855541 ccgggaaata gacagcctcg tcttctttca ggccgttcac tttgacatgg aagtattttg 3855601 ccgcatccga ttcactgatc atgtaaacag ggggaacagt ttctccttcc tgatagcgaa 3855661 cataggaaac atctattttg tctttcgtat acgtaaaacc gtgtgttttc agttcatggt 3855721 caatatcttt caaatgagtc tgttcttttg gattgttgct gtaagataaa tactccattt 3855781 cataagcgga ctcttccgct ccgacggtcg atttgtacat tgcgagcacg cctgtcgcag 3855841 taaacgcaac cgcggaaata atgctgacaa taaagaacag gcgggcgttg tcttttagac 3855901 gatagacaag gtcagaaacc caaatgatgt ttttcccgcg cagataaaag gttttccact 3855961 tcttcagcgc gcgcagaatc catatgctgc tttggctgaa aaagaaatat gttccgataa 3856021 cggtgagcag taaaatgata aacggttcgg ccccgtggac attgccttta agaaccatgc 3856081 cgtacccgcc gcacagacag gcgatgccga ataaggacag aagcacggac ggcttaggct 3856141 ccggtttaac cttgccagtg ccctttatta atttgataac cgtatttgat ctgacaaaaa 3856201 ggatcgtaaa ctgcgataaa aagaaaaata agagcagaaa tccgcaggcc gtaataccga 3856261 gcgctttcca aggcatatac aaaggcagcg cgtccatttc taaaatataa gcgccgaccg 3856321 taaagaacgt ctttgaaaaa atgaatcctc cgataatacc ggctgcaatt gacatgacgc 3856381 cgatgatcat attttccgca gtaatgagct ttctcagctg ccccggcgtg atgccctgca 3856441 tgagcagaat gccgaattct ttatttctcg atttcaaaaa tgcattaacc gaatacagaa 3856501 caaataagaa agaaaaaaca aagatcatcc attccgcggc ggttaagcct tttttggcga 3856561 tgttattcag gtagccttcc tttaatgccg gatgaaacag gaacatcgca aaggtaaaga 3856621 aaatcaaaac ggaaaaggcg ctgcttaaaa agaatgcaag ataggccctt ttgtttctcg 3856681 tgacgttttt ataagcgaac tgaagaaagg tcatttgcgt ttccccccag catagacagc 3856741 acatcgagaa tttgttcata aaatacttgg cggttttccc cgcggtaaat ctcattaaac 3856801 agttcgccgt cttttataaa gatgacgcgg cggcagtagc ttgccgaaac cggatcgtgg 3856861 gtcaccatca aagccgtgac atgatcatcc cgattcaggc tctgcaacgt ttccatgacg 3856921 tcttttgtcg ctttggaatc aaggtttcca gttggttcat cggccagaat gagtgacggc 3856981 ttatgaatga ccgctcttgc gatggcggcc cgctggcgct ggcctccgga tacttcaaac 3857041 gtccgcttgt taagcaggtt ttcgataccg agctttgccg cgatgccgtg cagtttttct 3857101 tccattacag acggcgcttc tttttcaagc gttaacggca gcatgatatt ttcaccgatc 3857161 gtcagcgtat ccagaaggtt gaaatcctga aacacaaatc cgagctgctt gcggcggaaa 3857221 tgagcgagct ttgtccgctt caggcgatgc gggttttctc cgttaatcag gatatcgcct 3857281 gaatctggac ggtcaatcgt tgaaatgata ttcaaaagcg ttgtttttcc ggacccggac 3857341 ggccccatca ccgccgtgaa ctcgccttct tctattgaaa atgaaatttg ctttaaggcc 3857401 tgataggaca cttgtccttt ataggtttta tttatatgtt tgacttcaag catattcgcc 3857461 atgaaaatcc tccttatggt tttattcttg ttgatctggg ctgctttcat gtagtgccgg 3857521 gacgttcaac ataaaaatcc ccttgacata aatccatgtt atcaagggga aacaaagcgg 3857581 gctatgttgt tttcttaacg cagccttaca tttttgtaag aaatgaaaat cgaactgatg 3857641 tcccttcacc gggagacgag ctgatgtcca ccgtatgatt gagcttatct gtaatttctt 3857701 tgacgagatg gaggccgatt cccgtagatt cttggaaacg ccgcccgttt tcacccgtgt 3857761 aataagggtc aaacacccgc ttgatgtctt gtgagggaat cccgacaccg taatctttga 3857821 cttcaagcac cgtcctgtct tcatcgcaga agacattcag ctcaagtctg tcactcttgc 3857881 ccgctgaata cttgaccgca tttgtgacca cttggccaat cgcaaatttg agccatttgg 3857941 catcggtgta aatctgatga tcatcgcaaa cgttcatttt cggataaacg cgatattgaa 3858001 taaaaaatcg tttatagctt tgaataactg attggagaag ctcggacagg gaaaccgctt 3858061 cgattttaaa atcccgttca aacaggtcga gccttgaaga ataaagaagc gtctccagcc 3858121 cgaattcaat ctgccggact tcttttttga tttgttcaaa aacgggctca tcctcttctt 3858181 gaatgattaa attaatgacc gacagcggcg tctttacttg gtgcacccat tgattcatat 3858241 acgtcacccg cgcgtcaagc ttggcttcgg tctcatggag cttctggtgc tgcagccgga 3858301 tcagctccat ctgcttttca tacagctctg aacagaacac tgaagaaccg agatacggga 3858361 tatccgtccc ttcctgcccc gagctgagcc aatgatacac gccgcggtct ttgtaccagc 3858421 gataggcaag atagcccgcc aaaataagaa gctgcacgcc caatatgtaa aacaagtgag 3858481 aaaaagaatg aagacccgca aaccagtaat aaaagaagac aaacagccct tgaaggagaa 3858541 aaagcagaat cagcactgca tgagaccgga gaaacagctt catgactgcg ccctcagctg 3858601 gtagccttcg ccccgcaccg cttcaataga aacaggcgca ttcagctccc gcagtttttt 3858661 tctgagccgc gtgatataca cgttaagtgt attatcatcg atgaatatgt cggtgtccca 3858721 cgtcttttcc atgagacggt cccgactcgt caccttttct ccccgctcaa gcagcacttc 3858781 caaaagcttg ctttcttttt tagaaagctc acttttttca tcctgaaaac gcagttcaaa 3858841 ccgttccaca aagagctgaa cgccggcata ttcaaccact ttctctccct gctttgcggc 3858901 gtactccccg tacgccctcc ggatctggct tttgattttc gcaagcacaa tatcataaga 3858961 aaacggtttt tcgatataat cgtctccccc attttcaatc gccatcacct gatccatttc 3859021 cccgcttctg gcagaaataa agatgatcgg gcttgtggag tgctggcgga tctgccggca 3859081 ccaataatat ccgtcatatg ccggcaaatt gatatcaagc agcaccacat cgggcttttc 3859141 ccgcaaaaag acatcaagaa cagctgtaaa atccgcggcg accactgttt gatatccgta 3859201 tttttcaagg taattctgca atagtccgcg aatgtcttca ctgtcttcca caatcatgat 3859261 tttattcaaa ctgaaccact cccgtttctt acactgctgc catcatcata atcgttttgg 3859321 gcgtatggac gcaacaccgc acaaaaaaac cgccatctcg gcggtttctg gtctctttag 3859381 ccgacctgct gcttagctgc tttaccggct gatccgaact ctctcatttt gcttcgcact 3859441 gtctcttcca cggcttcaat gccgggtgtc aaatagccgc gcggttcgta cagatcgctg 3859501 ttttcctgaa acatgcggcg tgtttcgtct gtccacgcta ccatacattc cgtattgata 3859561 ttgatcttcg cgtggccgag cgtgatggct tttttgatct gatcctgcgg aatcccggat 3859621 gccccgtgaa gaacgagggg aatatcagtc atgcgggaga tagcctccat ttccttaaat 3859681 ccgagattcg gctcaccctg atatttgccg tgtacagagc cgagggcggc ggccagcgcg 3859741 tcgatattgg tttctttaac gatccgctca cattccgtga tatccgcata gcggaccccg 3859801 ccgaccagtc cgtcttccat tccgccgacc gtgccgactt cggcttctac tgacacgccg 3859861 tgttttgcgg cataatcggt gacttctttt gtcatcgcga tattctcgtc aatcggctga 3859921 tgggagccgt caatcatcac tgagctgaat ccggcatcaa tggcctgtct gcagcgttcc 3859981 gcactgctgc cgtgatcgag atgaagcacg accggaacgg taatcgccat gtcctctatt 3860041 aacgcgccga ccatggcggc aatcgtttta aatccgccta aatagtcgac caggcgatcg 3860101 gaagccgcgg cgatgaccgg tgattgctcc ttttgcgccg cctgcaaaat cgccttcgtc 3860161 cattgcaggc cgttgatatt aaactggcca attgcatatt gctcccgctt tgcatcttca 3860221 agaagctctt tcatcgatac aaaagccata ttcacccctc ctttatccat tacatgctga 3860281 agtattttga tacgacatcc actgttgttt ttttcgctgt ttgaatggct tcctcagcag 3860341 tcagcttata gtattcaggc cggaagagct caaccgaaac aacatcagag aagccgattt 3860401 ccttcagtgc tgataagtgg gcatctaagt caattgcccc ttgtcccggc catacacgat 3860461 cctcatctgt taaaaagccg attgggaaat cttctgtatc atcaatatga tagatgaaga 3860521 ttttctttcc gtccgcctgc tttaagctct caatatttga acccattgca tggaagtgaa 3860581 aactgtcaag gacaagcccg acattgtcac ggttaactgt gtttacaatc tcatacgcct 3860641 gttcaaacgt attgaccgta cattgcggat ggccgacaaa ctcaagcgcg atttttacgc 3860701 cgtacggctc cgcgatatct gacagctcag tcagcacgtc tacactgctc tttttgatct 3860761 cttcttttac aatcttctgc tctgtcacaa gcggaacggc caccacatat ttcacaccga 3860821 gggttttgca tgtttccatc atgcctttaa attcagtgat gatctcgttg tgaccctttt 3860881 catcacggtt gttgaagaaa acgagtgcgt ttaaggcaag cggtttgatg tggtgggttt 3860941 gaaaatattc cgcaaggtca tccaatgaat gatcttttaa gtactccggc agcttatcca 3861001 tagtacggat ttcaatataa tcatagccat gcttttcgca tagttctaaa tccagtttaa 3861061 ggtttgagtt ttccaatgtt gtcgcttcat taaaacaaag tttcatgcca gactccccca 3861121 tctgcgtttt agatatgaag ggagttcggc aggaaggctg tcgccatatc ccgccgaact 3861181 ccatgctcag cttatgccag acctaattct tctttcattt tcttaagcat aaatcggctt 3861241 gattcatccg ctctttcatc gacccaagca aatacggcat tcgtcgcaat tccgtcgaac 3861301 ttcatctctc tcagttttct gaaaatcgta tcaaaatcaa cctcgccttg gccaatgtcc 3861361 aaatgctggt gaaccgttac tttcgcgtca ggcggattga cgatgtagcg aaggccatga 3861421 gccgctttat gattataggt atctgcaaat aaaacatgtg tgaggcggtc gccggcttcg 3861481 tcaaacatgg tctcgatgtc gcctttgccg tcatcataga agaacgtatg cgcagtcgag 3861541 tagacaagat tgatccaatc cttgtcaagc gcgcggatca tatccatcgc acctttgtgc 3861601 gtttcgataa aatcatatgg atgggcttga agattgagtt taatgccttc tttttcaaag 3861661 actggcagaa gctcatccat ggatttgata aatttttctt cacttgttaa aggatcatat 3861721 tttgaaccgc tgaattcgct gttcatcaaa tccacttcaa gttcaaccgc aatttcgatt 3861781 gcccgtttcc agttgcgcac tgctgcctgg cggcggtctt catcgggtcc cgcccagtgg 3861841 taaagaggaa gaagcgatga aagcttaaca cctgtatctc ttaaaaggcg ctttaattgt 3861901 ttgatctttg ctgaatcgac tttcggatat ttataaaacg ggcaaaaatc ctcgcgcggc 3861961 gataattcga tatattcata gccgagctct gccgttttat agaccatttc ctctaaagtt 3862021 aaatcatcac gatacatgga tggatccaat gctaacttca tattttcact cctctgtttt 3862081 ttagttttga actgttgtaa aagattgata gaattccggt ttttccttca attcaacctt 3862141 ttctttttgt ccagattcct gggcttttac acacgcgtca gtcgtgacag cagcaatata 3862201 gccgtcccat gccgtcggtc cgctgacctc gcctttcttt tgaatcgaat caataaagtc 3862261 ttggatttcc acatcatacg cagcgacaaa gcgtctctgc caatccatca aaatatcagt 3862321 gctgaatctg ccttcttttc tcaagctgat gcttgatggc tcgggaagct tgatgatgcc 3862381 gtcttctccg acgatttcac attgaatgtc atagccgtat ttacagttca catagatttc 3862441 agcattgatg acgataccgc cttttgtttc aatcacgacg atttgcggat cttttaaatg 3862501 tggaagcgcg ttttttgatt ttttcggata gatgacttga acggactcgt agtcatcatt 3862561 gacgagccag tggagcacgt caatttcatg aacaagcgtg tcgactacag ccatatccgt 3862621 tgtatagtta tctcctacag tcgggttgcg gtgcgcgcag tgaatcataa gaggctcgcc 3862681 gatgacatga ttatcgagcg cttctttcag ctgtacgtaa ccgctgtcat aacggcgcat 3862741 gaagccgact tgaacaaggc gtttgcccac tttgatttct tcttcgacaa tgcgcatgca 3862801 tccttcagcc gttgtcgcga gcggtttttc acagaacaca tatttctggg ctttaatcgc 3862861 tttcagcacg cttgactcat gcgcaggccc ccagcttgtc actaaaacag cgtctacatt 3862921 ttcgtctgca agcaagctgt catcattcgg ataaaccgtc gcgtttaatt ggtattgctc 3862981 aacgaccttt tgtgcagctt cttgattaac atccgttaca gctacaattt ccgcgcctga 3863041 cagcttgttc gtgatacggt taatatgttc ttttccgatt gctccagttc caattacgcc 3863101 aatacgtaaa ctcattgaca gccactcctt ctgttggtta catgattttg ctttctgttc 3863161 ctttctttac ttggctctga ggagacccgt agagttcctc ttgaatttgt tcaagcgact 3863221 tgccagacgt attcggcgca aagagcagcc cgatgatcat actggccgtc acacatccga 3863281 gaagaattgc agccatcgtt ccaatgccga aattggtgat aatcattggg acaaacagac 3863341 tccaaatccc tattgaaata cggacaagga aaaacatcag tccttgtgcg gaagcacgat 3863401 attgcgtagg aaagatttcg ctggcccata actgatagtt cgcttgctgc ccggctccgt 3863461 tattgatgcc gatcacgaca ataaacagga gcagaatcgg caggccttca actggcagca 3863521 gaaacagtgt ccacccgatc accgccatga aagcggcgat tccaaatacg gtttttctat 3863581 atttgtcggc aaagggcatg aagatcaagg cgacccccaa tcctgtgaag ataaacagcc 3863641 ccatttgcaa aaggttggcc atgttggcag atacaccgcc gacctgctga taaatgtatg 3863701 gcataaagaa gcccatgacc ccggcggcta ggttccaaac caagtacaca cccatcaaaa 3863761 acaggatgct ttttagatac ataggcttga gcaaatcaaa atacgatgtc ttattcaata 3863821 cagccggctt ctctgcctga gcttcctccg gctgattttt tgtctgccag gcgtctgatt 3863881 ccggaagcct gattctcagg atgtacgtaa tcagcgcaat cacaagcaga tgggcaaata 3863941 cgattttatt ccccaagagt cccaagtcac cggccagtac ggagaggagc agtacaacga 3864001 cagcgcccgc ggcccaagcg acttgtgcta cgccgcaatg cctggcccga ttcttctttg 3864061 gcgcattttc cgcaataatg gtccatgacg cggttatgtc agcccctact gataaaccga 3864121 taatgatgta accgcttaac aacatgggga aattaacccc gaacaaaacc aaacaaatcc 3864181 ctagtgcata aaccagcata ctattggtat aaacagcctt ccgtccgact ttatcagcca 3864241 gaaacccgcc aagcagcgcg ccgacagcgg cagaaatcgc atttgcgctc aacgcgccga 3864301 gcagcccgat ttgcgtatcg gatagcttaa ggtaactgac ccataatgat aaaccggcgg 3864361 agcctgccac aattgaaccg gcatcaatat agttggccaa tgctgccgcg attgtccgtt 3864421 tattgaaggc tgaatctcca ttggtattgc ccatatgttc attccccatt aagccagatc 3864481 caacaactgc tgatcaatat agtttctcgc aatcaatgca tactccagcg ggtttgcaac 3864541 atcggggtct tgttcagctt caatgacaat ccatccggaa taactgtgct tcaacagcag 3864601 ctgatatact tctctaaagt caatgcagcc gtcaccggga accgtaaaca tgccttttaa 3864661 aaatgattgc cggaacgatt gtccttcgag cctgcattgt tccatgacat tcaggcgggc 3864721 atccttaaag tgcacatgct taatgcggcc gatatgcttc tcaagcatcc ccatgtaatc 3864781 gccgtcagaa atatacgcat ggcctgtatc atagaggagg tgtacatgcg cagggtctgt 3864841 tcctgccatc aggcggtcca cttcttccgc tgtttggaca ccagtgccga gatgatgatg 3864901 atagacaagc ttcaagccat gctgagcggc aatttcgcca aggtgattca gcccttcgca 3864961 aagccgctcc cattcatcat ccgtaaagtg cggcttctct gtgaacacat ttttctccaa 3865021 gctttgcacg ctgtacgttt gttcagagac aactgcgaca tccgcgttta cttgctgcaa 3865081 atactcacaa tgcagggtaa atgtctttgc cgcttcacca agtccgtcac gcaaaataaa 3865141 actgctgaac cattttcctg caatgcgtaa gttccgaagc ttcagctctt tgttcaggat 3865201 ggcaggttcg gggaaaaagc ccccgacctc cgtgccttga aaacgtgcga caacgatatc 3865261 acttaacaaa tgctgaagtg tatttcccgc tccaatttca ggcatgtcat cattccgcca 3865321 cccaatggga gcgattcccc acaggatttc atttttgccc atctatggtg cctcccctct 3865381 aatactgctt cgcagattcc agctttttct cttttgcttc gtatgctttc tgaacgcttt 3865441 cttgttcaga tacctctgcc accccgacat gccaccagct gtcatagccg tccgtcattg 3865501 ttttaggcag caccttcatt tcaattaatg ttgatacatc ctgtttcttc gcatcctcta 3865561 acgcagcttt taattcttct actgtgtttg cacggtaggt tttcgcgccg tatccctcag 3865621 cgactttcgc gtaatcgaca ttcaggattt ggttgtcatc tgtgcggaac tcgcaatagt 3865681 agctgccgct gccgtgatcc atttgcaggt tgttgatgca tccgaatcct gagttgtcaa 3865741 agagcagcac attgattttc ttgttgtact gaatcgccgt gatcagttca gaatgaagca 3865801 tcaggaagct gccgtctccg acgattgaat acacttctct gtcagggtgg gccagtttaa 3865861 gaccgagtgt cccggacact tcatagccca tgcaagaata tccatactcc aggtgatacg 3865921 tattcggaac attagaatgc cacagacgct gcaaatctcc tgggagtgag cctgctgaac 3865981 agatgatgac gctgtcttca ggaatcgtct cgttgattgt cagcaatgcc gttgtttgcg 3866041 gaagctccgt attcaacgcg tcagcatatt cattcaggac ctcttgagaa aagtgatttt 3866101 tgatttccgg atcaaatgct tcccgcttaa acgtcacttt gctgagacgc tcgcgttcag 3866161 ctagccattc gtccttcagc tcccggatcg ttgtgccgaa ctcgctctca tagccttcaa 3866221 gcaagccgtg cagtttgcca agcgtcactt tcgcatccgc caccacttgg aatgcatcaa 3866281 gtttatacgc ctgcattcgg ctgacgttaa tgttcaaaaa cttcgcttta tcaaaatcaa 3866341 aagcggtctt agaggatgtc gcaaaatctg tataccttgt gccgatgccg ataatcaaat 3866401 cagcttggcg ggccgctttg tttgccgcaa gtgtacctgt gatgcccatt ccgccaaggt 3866461 tgttcgcaaa atctgcctca acggtagact ttcctgcctg cgtttcaact aacggaatgt 3866521 tataggcttc agaaatggca accaattcat cgcgcgcacc ggaatatttt gcgcctccgc 3866581 cgacgagaat cacaggtttt ttgctggatt taatcagctc cgccgcacct tgaagctcgc 3866641 gctcgctcgg ctgcatgcga tcaatatagt gaacccgttt gacgaagaaa ctttcatcaa 3866701 aatcgtatgc ttccccttca acatcctgag aaatacaaat cgttgccgga cctgcttttg 3866761 ccggatcagt catgacttca aacgcgcgca gcaaactgct catcagctgc tcagggcgcg 3866821 taatgcggtc ccagtatctc gatacaggct tcaatgcatc gtttgtcgta atcgccgcac 3866881 tgtattcttg ctccatttgc tgcagtacag ggtctggctg tcttgtcgca aatgtgtctg 3866941 ccggaatcaa gagaactggg atattatttg ccaatgcagt gccggctgcc gccaccaagt 3867001 tagccgctcc aggtccgacg gatgtagaca ccgcatatat ttttcttctc agcatttgct 3867061 tgctgtacgc catggccgca tgcgccattc cttgttcatt tttcccttga tagactttca 3867121 aatggcctgc atcctgctca agcgcctgcc cgatccctaa tacgtttcca tgaccgaaaa 3867181 tcgtgaagat cccttcgaca aaaggctctt cctttccatc tacatggatg tactgctggt 3867241 ttaagaattt aatcagcgcc tgcgcagttg ttaagcgaat tttcttaccc acaaacgatc 3867301 ccacctttac tcgatctttt tcaattatga ctgtgcttca ataagctgtt cgatttcttc 3867361 cgcagtcggc atcgcttctg acgaactgtg cttgctcacc acaatggagg ctgaagcact 3867421 gccgtatttc aatgccgttt caatgtcttt tccgctgaca aggccataga taaaggctga 3867481 cgcataggag tcaccggccc caaaggtttt cagcactttt gtcttgtacg cttgagcgcg 3867541 gaatacctcg ccggatttgc tgtatgcgta agagccttcg acgccgtgtt tgatgacaac 3867601 gaggtcggct gaatggccaa ataaatgatt gacggattct tcattgcttc cgcctgtgcg 3867661 gttttccatc acatcaaatt catcgcgtgt gccgatgacg atatcagact gctcggcaac 3867721 caaagaataa taaacggctg tttcatctga tgactgccac gtatatggcc ggtaatccag 3867781 ttcgaatacc accttaacct gatgcttttt cgcgtattga acagctttta acaccgcttc 3867841 ccgtgacggg cttttggcga gcgctgtccc ggagacaagc agcattttcg catttgcgat 3867901 atagtcctca cttacctctg aaggctcaag ataaagatcc gccacatcat cgcgatacat 3867961 taagatgctg cattcttcag ggctgaggat ttctgtaaat gcaaggcctg ctttgtgtcc 3868021 atcttgatca acaatcatct gtgtagtatc cacgccggtc tttctcatat aggactctat 3868081 gaatcttcca tgctggtcat ccggaatttt gccgatgaag cccgctttta agccaagctt 3868141 cgcgctgccg atcgcgatat tcgcaggtga accgccgaca tatttcgaaa atgtcatcgt 3868201 ttcttccatt gggcggttgt attcgactgc gttcagatca atacatgccc ggccgatggc 3868261 aacaatatca aaagccttct cttcattgaa tgtatacttc atcgtaaaca gccactcctc 3868321 acttgttagc gttctaaaat ccattcatgc gccgggtcgt tataaaactt ccattttcgc 3868381 gtcggccctg ccatgacatt taaatagtag gatgtgtatc cgtccggaac gcctaccggg 3868441 tggtatcccg caggaacgat gacaacgttt tcatttccca cagtcattgt ctcgtcaata 3868501 gaacggtcat ctgtgtatac gcgctgaaac acaaagccct gtcccgggtc taactcatgg 3868561 tagtacgttt cttctaagaa agattcttcc ggcaagttgt cttggtcatg tttgtgaggc 3868621 gggtagctgg accagttgcc gctgtctgta tagacttcaa ctactaatag actgttagct 3868681 gaagggtctg aatccggaag aatgttatga acagtacgtt tgtttgaaaa ttgcccgcga 3868741 tgctcaattc cgttgtcttc cgctttgatc agctttgtcg gaagctgctt ttccgatgga 3868801 gaatagcaaa gcgccactct tgcgtcgctg accgctgtga tctcaaatgc acggtcattt 3868861 gaaatataga cgctgtctgt cggttttcgt tcaaatacgc tttcgcgcgt gccgatattc 3868921 tcaaaagtcg actcatgatc tgtcactgta attttccccg ttaccgccac aatacagatt 3868981 tcttgttttt tcaattcttc tgtatagctt gaacctgatg caagatctaa cactttaaac 3869041 tctacataag tgagatcaga gttggatgtc gttacttcgt gcacgagttt gaccccatta 3869101 gacacttcat gcgactgcgg cttacgcaac aaataactca tagagaagcc ctcctctttc 3869161 tattggcaga atgagtccga acagcgcaca tggacgccgt tcggctgttc gtcgtttagt 3869221 tgaaatcagg tgccggatat cttgccgtca ccactttttt acgtgtatag aagtcgacgc 3869281 tgtcttttcc gttcgcatgc agcgttccaa agaatgaaga tttccagcct gagaatggga 3869341 agaacgccat tggagccggc acaccaaggt tgatgcctag cattcccgca tcaatgtttt 3869401 cacggaagta gcggattgcg tttgagttgg atgtgaacaa gcaggcgccg ttcgcaaact 3869461 cagacttatt ggcgatttca atcgcttctt tcaggttttt cacacggatg acagataaga 3869521 ccggagcgaa aatttcatct ttccagatcg tcatttctgt tgtgacattg tcaaagatcg 3869581 tcgggccgac aaagtagccg tcgtcagaca cattttcacg tccgtcacat acgagtctgg 3869641 caccttcttc aagacctttt tcgatatagc tgagcgtgcg cttcttgttg tcttcgcgaa 3869701 tcaccggtcc taagaacacg ccgtcatcaa ggccgttacc gattttaatg tccgccactt 3869761 tttcctgcag cttcgccata aattcatcgg cgattccttc ttcaactgtc acaaccgcac 3869821 aagccatgca gcgttcaccg gcagaaccga aggcagctcc aacgatgttt gtaaccgtgt 3869881 cttcaagatt cgcatcgttc aagacaatcg tatggttttt cgcgccagtc agagattgaa 3869941 cgcgttttaa gttttcgctt ccttttttgt agacgtattc gcctactggc ttggagccta 3870001 caaatgaaat cgctttaatt tcgggatgct cgaggatgcc gttcacaacg tcatgcgcac 3870061 cgtatacgac gttgaacacc cctttcggaa ggcccgcttt ttcaaaaagc tcaaccaatt 3870121 tctctgttaa cagcggagtc cgctcagatg gctttaaaat aaatgtgttg ccgagcgcga 3870181 tcgccatcgg gaacatccag caaggaacca tcatcgggaa gttgaatggc gcgattccgc 3870241 cgacaactcc gattgggtaa cggtagttcg ccgcttcaac gtccgttgcg atggaagcaa 3870301 gtgagtcacc catcatcagg gaaggtgctc cagcggcgaa ctctacgttt tcaatcccgc 3870361 gtcccacttc acctaaagct tctttcgtgt tttttccgtt ttcaatggta attagatgag 3870421 caagttcttc tttatgctga gacagcagct gctggaagtt aaatagaatt ctggcgcggc 3870481 gaggaaccgc cacctttgac catgttttaa atgcttcagc cgctgtttgc gctgcgtaat 3870541 caatatcctc ttttgtagaa atcggcactt ggcatagcac ttctttcgtc gccggattga 3870601 cgacatcttc atattgatct gttttgcttt caacccattc accgttgatg tagtttttta 3870661 attttctgat ttctgccatt cttattgcct ccttcattag taaacacata cacttgtatg 3870721 gatggttccg gatagattca tatcaatatc cacttttcag caagccaaga attaaacgct 3870781 ttcaaaaaca ccaaaaaaat aaatggcgga tgcatattta catacaagca accatttcat 3870841 gcacaacagg ttactttttg gtcatttctt ggttatattc taatcgcata atacccataa 3870901 gtcaatcata aacactacat tttttcatta tttttattat attaatcttt taatcaagta 3870961 agagaagtaa gagaaggccg tccaatcttg caaaagatat acaccgatgt tatcattttt 3871021 aagcaactat tgattaactt ttggttttta ttatatattt atgttacgta aagattcaag 3871081 aaggagtttt ttatatgaaa ctgatgcgga ttcaggaaat ggaggagtac attttatcgc 3871141 atggcactgt ttccttagat gagctgtgcc aggtgttcaa tgtctccaaa aacacagtca 3871201 gacgtgatat caacaagcta acagaaaagg gtgcgattga aaaagtatac ggcggcgtaa 3871261 catctattga aaaaaccgca ttagttcctt ttgaaaatcg caccattcag caccaggatg 3871321 aaaaaacaaa aatcgcccat tatgcttccc gatttattga agatcacgat ttggtcttca 3871381 ttgattcagg aacgacgaca aagtctattc ttgatacgct tgatccagcc aaaaatgtca 3871441 ccatcttaac caacagttta gacattatca atgcggcgtc agctttgaag aatatcaact 3871501 taatcattat cggaaacaac tataagagaa aaacccgctc ctttgtcggc atggacgacc 3871561 cggctatgct tgataagtac aatatcaaca aagcctttat gtccgctacc ggaacgacgc 3871621 tgactcacgg attgaccaat tcggatctgc tggagtatga aattaaaaag aggatttcag 3871681 aaaaagcaaa agaagtgtat ctattggctg accattctaa attcggaaaa tcaacgcttc 3871741 tgacgtatgc accgtttgac aggctgcatt gcattgtgac ctctcagcca ttagacgacg 3871801 agtacacgca gtactgcaat gagcatcaaa tcggcattca tctggcctaa cgtttacaat 3871861 agtgttgaga gtctatcatc cattttattc taggaggcag atcatgaaaa aagcgaagct 3871921 cggaaaatca gacttgcagg tattccctat cggattagga acaaatgctg tcggaggaca 3871981 taacctctac ccgaacctaa atgaagaaac cggaaaagaa ttggtgcgcg aggcgatccg 3872041 taatggcgtg acaatgttag acaccgctta catttacggg atcggccgtt ccgaagaatt 3872101 aattggtgaa gtgctgcgtg aattcaaccg tgaagatgtt gtcatcgcga caaaagccgc 3872161 tcacagaaaa caaggcaatg actttgtctt tgataattca ccagattttc ttaaaaaatc 3872221 agttgatgaa agcctgaagc gcttgaatac cgattatatt gatttgttct acattcactt 3872281 ccctgacgaa catacgccta aggatgaagc cgttaacgcg ctgaatgaga tgaagaaagc 3872341 cggaaaaatc cgttccatcg gtgtatccaa cttctcttta gagcaattga aagaagcaaa 3872401 caaagacggt ttggtagatg tattgcaagg cgaatacaac ctgttaaacc gtgaagcgga 3872461 aaaaacattc ttcccgtata cgaaggagca taatatttca tttatccctt acttccctct 3872521 cgtatcaggt ttattggcag gaaagtatac agaagataca acgttcccag aaggcgacct 3872581 gcgaaacgaa caggaacact tcaagggtga gcgtttcaaa gaaaatatca gaaaggtcaa 3872641 caagcttgcg ccgattgccg aaaaacacaa cgtggatatc cctcacatcg tattggcctg 3872701 gtatttagca agaccggaaa ttgatatttt aatcccagga gcaaaacgtg ccgatcagct 3872761 gattgataac atcaaaacag ctgacgtgac gctttctcaa gaggatattt catttattga 3872821 taagctgttc gcataagaag aaaacagcct tctccaatgg agaaggctgt ttttttgtgc 3872881 gataaattcc taaataactg attttgaagc aaaaccttac aaaatgagcc ataaatccga 3872941 taaaataaag gtagtttatc tcagaaagaa agtgattgag aaagcaaaag tatgaaacgt 3873001 tcatatcatc tagctcatat gaaataaagc tgacccagct tcttttattt gctggtcaga 3873061 atagcggacc gtttcgatgg tctatggagg aaacagaatg aaacttaaat atgtaaaagc 3873121 cttagttgca gtaaccgttg ctttaggtgt actgctgcca tcaacgattt ctcatgcaaa 3873181 gagctttagc ggccgctcat catctagtta cagcagccga agttcaagct catcatacag 3873241 cggaagctat aaatcaagcc cgaaatcaag ctacagctca ggatcaagct cttctagcaa 3873301 aaaatccaag acgtctgacg attcatcatc atcgatttcg cttaaaaaga agccttcgga 3873361 aaaggcaagt tcatcaagct ctaaaaaatc gtcaggcacc ttttccggcg ctacatcaaa 3873421 agtaaccgga aagacataca gcggaaaaac gtctaaagcc tatgttggcg gacgttatgt 3873481 ttcagtcaat cattactatc acgcaggttt cgcgccatca ggatggtttg gatattatag 3873541 cggatttaca atgggtatgt tcatgatcag catgatgcac ccatggggtt acacctatca 3873601 tccagtcgga ggccccggtt atgtttctta tggcgcttca cccattgcct ggatcgttga 3873661 tatcatcgct ttgattatta ttttaatcat tgtcatcgca ttgattcgcg catttaaagc 3873721 accgaagacg tacagaagga gattttaggc aatgagatta atattaaatg agcaagaaat 3873781 tgtagacgga atttgcgtgt atatttccaa tgaagaagat atctaccctg aagacgttga 3873841 agtaaaagaa ctatcgtaca acaagcgtac agggttcttc gctgaagcta catttggcct 3873901 gcaccacaag cagcttatgt cagatgacat ttcagaaggc attattcagt tcttagagga 3873961 ataccacaac ttcaatccgg acgttaccgt cgttgaattg caatttgata agaaaaaagg 3874021 cttctccgcc ttggtttttg tcaacgaagc agaagaataa aaatgtctta atcaaacctt 3874081 actccgcgcg ggtaaggttt ttttaatggt ttctctgagc ataaagttat ttcgtttttc 3874141 ctaaactcag cggatctgtg atcatctctt ttggctataa agtttccgtt ttttcaaaac 3874201 aaatgtttca aatgagatag gaaatgggta ctaatctatt aactttgtta catattttta 3874261 gatactcatt ggctcaacaa ctgaggagga gacatttgtg aagaaagaca caaggaaata 3874321 tatgatctac tttttcggcg ctttaggggg actgctatat ggttacgata caggtgttat 3874381 ctccggagca ctcctgttta tcaataacga tattccttta acgacattga cagaaggatt 3874441 ggttgtcagc atgctgctcc ttggcgcgat tttcggttct gccttgagcg gcacatgctc 3874501 agaccgctgg ggcaggagaa aggttgtatt tgtcctttcc atcattttta ttatcggtgc 3874561 gctcgcttgc gcattttctc aaacaatcgg catgctgatt gcatctaggg tgatactcgg 3874621 gttggccgtc ggcggttcaa cggcacttgt gcccgtgtat ctttccgaaa tggcaccgac 3874681 gaaaattcgc gggacactcg gcacaatgaa caacttaatg attgtcaccg ggattttgct 3874741 cgcctatatc gttaactacc tgttcacacc gtttgaagcg tggcgctgga tggtcggtct 3874801 ggctgcagtg cctgccgtgc ttctattaat cggcatcgcc ttcatgccgg aatcgccaag 3874861 atggctcgtg aagcgcggca gcgaagaaga agcgagacgc atcatgaaca tcactcatga 3874921 ccccaaagac atcgaaatgg aattggcaga gatgaagcaa ggggaagcgg agaaaaaaga 3874981 aacgacactt ggcgtgctga aagccaagtg gattcgccct atgcttctga ttggcgtcgg 3875041 ccttgccatt ttccagcagg cagtcggcat taacacggtc atctactacg cgccaaccat 3875101 ttttacgaag gccggtcttg gcacatcagc ttcggcgctc ggcacaatgg gaatcggcat 3875161 cctcaacgtc atcatgtgta tcactgccat gatcttaatt gaccgtgtcg gccgcaaaaa 3875221 acttctgatc tggggaagtg tcggcatcac actgagcctt gctgctttat caggcgtgct 3875281 cctgacactg gggctttccg catcaacagc gtggatgaca gtagtctttc tcggtgtcta 3875341 tatcgtcttt taccaggcga catggggtcc ggtagtgtgg gtgctcatgc ctgagctctt 3875401 cccgtccaaa gcacgcggag ccgcgacagg gttcacgact ttggtgttat cggcggctaa 3875461 cctgatcgtg tcgcttgtct tcccgctgat gctaagcgcg atgggcatcg catgggtctt 3875521 tatggttttc tcagtcattt gtcttctctc atttttcttc gcgttctaca tggtaccgga 3875581 aaccaaaggg aaaagcttgg aggaaattga agcaagcctg aaaaaacggt ttaaaaagaa 3875641 gaaaagcacc caaaaccaag tgctgaatga gcgtacatta taaaaaaagg aatcgtctcc 3875701 ttatgagacg attccttttt ctgtttacac catgaccttg caaatattgt tcgtaaattc 3875761 cacagggtcc tgaatcggca ggccttcgat gaggagcgcc tgattgtaca gaaggtttgt 3875821 gtacaggctc agcttctctt tatcttgttc aaacgcgtcc tgcagtgttt ggaatacctc 3875881 gtgatttggg ttgatttcca gcactttttc cgccttcaca ttttggctgt caggcatcgc 3875941 atttaagatt ttttccatct caattgtcac ttcgccgtca gcagcaaggc agactggatg 3876001 tgatttaagc cgttttgaga ttctgacgtt tttcactttg tctgacagaa tgtttttcat 3876061 ttcctcaaac agatccttat acttgctttc ctcttcctcg gactgctttt gatcctcatc 3876121 cgtgtctatg ccaaggtctc cgcttgatac ggacttgaat tctttttcct gataagaagc 3876181 cagcatttta attgcaaact catcgatgtc ctcagtaaag tagaggattt catagccttt 3876241 gtccgccacc atttccgttt gcggcagttt ctcaatgcgg tcgtaagaat caccggtcgc 3876301 gtaataaatg aatttctgct cctctggcat tctggaaaca tactcgtcta agctgaccag 3876361 ttttttctct tttgaagagt agaataagag gagatccttc aattgatcct tattcgcgcc 3876421 aaaatcattg tacacgccga atttcagctg tctgccgaac gacttgtaga acgtctcgta 3876481 tttctcgcgg tcttttttca acaggctttg cagctcgctt ttgattttct tgctgatgtt 3876541 tttcgcgatc agcttcagct ggcggtcatg ctgcagcatt tctctggaaa tattcagcga 3876601 cagatcctca gaatcgacca tgcccttcac aaagctgaag tggtccggta gcaggtctgc 3876661 gcacttattc atgatcagca cgccattgga atacagctcc aagcctttct catattcctt 3876721 ggaatagtag tcaaacggca tgttttcagg gacgaataga atcgcgttgt agcgaaccgc 3876781 tccatccacg ctgatatgaa cgtgtgtcag cggtttatca aacccgtaat gcttttcagc 3876841 atagaatttt tcataatcct catctgtcag ctcgcttttg ttttttctcc agatcggcac 3876901 catgctgttg accgtctgct cttcctgcac ctcttcaaat tcattttcgc tgccttcctt 3876961 cggcttatta atggttgtat ccattttgat cgggtagcga atgaagtcgg agtacttctt 3877021 gatgatcgct tttaaacgat attcctctaa aaactcgtca tagctgtcat cttctgtgtt 3877081 ctctttgatt ttcaggataa tgtctgtacc gacagaatcc ttttcacacg gctcaatcgt 3877141 atagccgtct gcacccgcag actcccattt ataagcctct tcgctgccaa gcgctttact 3877201 gatgactgtc acgacatcgg caaccataaa tgccgcgtaa aaaccgacac cgaactgccc 3877261 gataatgtca tgtccgtctt tcagctcgtt ttccttttta aacgcgaggg aaccgctttt 3877321 tgcaattgtt ccaagatgct gttcaagctc atcctttgtc attccgatcc ccgtatcaga 3877381 gatggttaat gttctcgcat ctttgtcagc tgcgaccttt atgtagtaac tgtctttatc 3877441 aaacgtaagc gcatcgtccg taagcgcttt gtaatagatt ttgtcaatcg catcactcga 3877501 attggagatt aactcgcgca ggaaaatttc tttttgggta taaatggagt taatcatcat 3877561 atccagcaag cgtttagact ctgctttaaa ctcttttttc gccactcttg atcgctcctt 3877621 taccattatg taaacccttt tcagcatcta tttatcacat aagatgacaa ttgtcaatta 3877681 gattgataga tgcatatata tgtaaattta acattagttg gatttgtttt cactcttttt 3877741 ctcactcatt ctcataaaaa agagaggctt catcatcctc tctttttttc tgtgtcattc 3877801 caacggccaa actcccgctt catccatata tgcaccgggt agaaaaacaa accgaacggt 3877861 atcaaaaaca aaagattatg ccatgaagca ttcagaaatg cgcttgcagt caccgggaac 3877921 gtaatctctt gcaataaaaa agagatgaca gtcagcacaa caaatgcaga tggaatggtc 3877981 acgatgcaat aaaacttgag ctccttctta tgctgtacct tcaaacatac aaacctccca 3878041 acaatttcta attcatctta acatatgctg gcctttcttt tctcgcatgt ttatcactgc 3878101 acatagcggg aagacaaata gaaaaaggag gtctcgtatc atgggaagac ttgaaaacaa 3878161 aacagcagtt atcacaggcg ccgcgacagg cattggtcaa gcgacggcgg aggtttttgc 3878221 caatgaaggc gcgcgtgtga tcatcggaga tatcaataaa gatcaaatgg aagaaacagt 3878281 tgacgcaatc agaaaaaacg gaggacaggc cgaatccttt cacctcgatg tgtcagatga 3878341 aaacagtgtg aaagcatttg ctgatcaaat caaggatgca tgcggaacga ttgatattct 3878401 gtttaataat gccggcgttg atcaggaagg cggaaaggtg cacgaatatc cggttgacct 3878461 gtttgaccgc attatcgccg tcgacctgcg cggcacattc ctttgcagca aatatttgat 3878521 tccgctcatg ctcgaaaatg gaggctccat catcaacacc tcctccatgt caggccgtgc 3878581 cgcggacctt gaccgctccg gctacaacgc cgcaaaaggc ggtatcacca acctgacaaa 3878641 ggcaatggca atcgactacg cacgaaacgg catccgcgtc aattccattt caccgggcac 3878701 gatcgaaaca ccgctgattg acaaattagc aggcacaaaa gaacaggaaa tgggcgaaca 3878761 attccgcgaa gccaacaaat ggatcacgcc gctcggacgt cttggccagc ccaaagaaat 3878821 ggcaacagtg gcactgttcc tcgcatcaga cgacagctca tacgtcacag gagaagacat 3878881 caccgcagac ggcggcatca tggcgtacac atggcctggg aagatgctga ttgaggagaa 3878941 atggaaggaa gaaacgaaat aagagaggga gccccctctc tttttgtctt ttaaagcaat 3879001 acaaccttat atttcttcac atccaaaaac tgcaaaaact ccctcgccag cacttcaggc 3879061 ggatgcgcct ttccttcatc cagccgatac aaaagcaacc cgataatcat tgcggataca 3879121 taatgggcat aaagcttttt ctctgcgtga atatcagttt gctgatgcag ataaaacgat 3879181 tccagcgctt tgaacatatc aggtatcaca tgaggaacac cccattcccg attgagaaaa 3879241 tggacaatgg gcatgtttga caaagcagaa agcagaatgg cgagcgcctt ctccgcttcc 3879301 tttaaggaaa attcattcgg gctggaggca atcgtcaggt gatcaatgat ctccgcacat 3879361 gatcgctgta tcatggtttg gagcaattcc tccttattgg catagtgatc ataaaaggtt 3879421 gcacggcgga tattgctttt acgcgtaata tctgaaatcg tgatgcccgc gtagtcttgt 3879481 ttctccgcca atacatccag aaatgccttc tgcagcgcct ctctcgttcg aaccacccgc 3879541 ctgtcgattt gcttctcctt ctctcgctct cctggcacag cttttccaaa cagccaataa 3879601 aaccgctttt gagaaacaag ctcccatacc ttctggctga tggcttcagg agacgcggcc 3879661 gcatcctcat tcagccaata caggataatc gcgtacgtgt acaaggcccg ataatgtcca 3879721 taaatgtccc gttcaatcgg cgttaaattc acatggatcg gagccagcag cacatcctgc 3879781 tgaaacacat ccttaaaaaa acgatgaaaa tgtcctctgt tcatcatcac agaaaaaaag 3879841 gaacgatgct catgaacaaa ggacagcgtc ggatgcaccg tttgccgttt tttgttcaaa 3879901 tgaagggtat ccatatgact gaaggcgtca aaaagcgctt tgcccagtcc ttccttcatg 3879961 tcttcgatca catcctcaat gattgaaaac ttatcctcat aataaaggta gagcgatccg 3880021 cggctcactt tggccttctc agcgatttct ttcattgtga tgtgttgaat atctctatct 3880081 ttcaataaag ccagcagcgc ctctttcact tgagcttcgg cagattccgg cacaaaagac 3880141 acctccaatc attagacaga tcttagatat atgtacggta acgtatagat ggttcaccgt 3880201 tgtctttctt acagaaaagg taccacctta taataggtcc gagaaaagaa gaaagcaaat 3880261 gagggggatt ttacaatgga acagcaagta aaggacgaca tccagcgtgt ctttcagctt 3880321 cagaaaaaac agcaaaaagc cttgcgcgct tcaacagcgg aacagcggag agaaaagctt 3880381 caacgctttt tagattccgt catcgcccat gaagaagaaa tcatcgaagc gatccgcaaa 3880441 gacgtccgca aaccatatca cgaagtcaaa aaagcggaaa tcgaaggaac aaaaaaagcg 3880501 attagagata atatgaataa cctggaacaa tggatggcgc ctaaagaagt cggttcatcg 3880561 ttaagccctg acgcaaacgg aattcttatg tacgagccta aaggcgtcac actcatcctc 3880621 ggcccgtgga actatccgtt tatgctgacg atggcgccgc ttgccgcttc tctcgcagcc 3880681 ggaaacagcg cgattgtgaa gctgtccgat ttcacgatga acacgagcaa cattgctgct 3880741 aaagtaataa gagacgcttt tgatgaaaaa gaagtcgcga tttttgaagg agaggttgag 3880801 gtggcaaccg aactacttga tcagccgttc gaccatattt tcttcactgg aagcacaaat 3880861 gtcgggaaaa ttgtcatgac agcggctgcc aaacacttgg catctgtcac acttgagctt 3880921 ggcggcaaga gcccgacgat cattgacagt gaatacgatc tgatggacgc agcgaaaaag 3880981 atcgccgtcg ggaaattcgt aaacgccggc caaacctgca tcgcacctga ttacctgttc 3881041 attaaaaaag acgttcagga caggttcgcg gggattttac aaacagtcgt caacgctgga 3881101 tttatggagg atgatcatac cccagaccgc agcaaattta cgcagatcgt caatgaccgc 3881161 aacttcaacc gcgtcaaaga tctgttcgac gatgccatcg aaagaggggc ggaagtggtg 3881221 ttcggcggcg tattcgatgc cagcgaccgc acgatctcgc caaccgtttt gaaaaacgtc 3881281 acgcctgaca tgaaaatcat gcaggaggaa atcttcgcat cgatcctgcc aatgatgaac 3881341 tatgaagaca tcgacgaggt catcgattac gtaaatgacc gcgataaacc gcttgcactt 3881401 tatgtgttca gcaaaaacca agatctgatt gacaacgtcc ttcagcacac gacatcagga 3881461 aatgccgcca tcaatgatgt cgtcgtccat ttcagtgacg tcaacctgcc attcggcggc 3881521 gtcaacacaa gcggaatcgg ctcctatcat ggggtatacg gattcaaaga gttttctcat 3881581 gagaagggtg tatttattca ggccgctgaa taatcgcatg atcaaaaggc gcttccttag 3881641 aggagcgcct tttattgtaa ctccttgacc aaaagcaatt catcacggat aggtatttta 3881701 ttatctgcca gtaaaggaat ttcgggcttc atctttctgg ccgtctcgac tgcattcaca 3881761 aatagtcgat ccaaccggta ccctctcttc tgataaaacg ctaatgcatg aatattatca 3881821 ttggttgtga tcagttttat ttgtttgata tttctctctc tgcatgcttc ctcggctttc 3881881 tctagcagag ctgttccgat ccctttattc tcaatgacac tatccagcga aatgatttca 3881941 caggcatctt cttcaaatat gtatgtaata aggccaacaa tctggttatc atcgttgagc 3882001 attccataac catctaattc atcgcagtta taaataccgc tagaaataac catttgcgga 3882061 ctgccccagt gtttttgaaa aaacgcggaa acaagatctt taggtacctg gcatgtcgga 3882121 ataatattca tattttcctc cttttagctg aacaaaaata agagaattaa caacctattt 3882181 tatgtcatta atccccttat ctagtattta ctagaactta taacttgtca aaagctgtct 3882241 gaataccaat tgcgtggatt gataaggatc aaaatctgaa tcctgagatt ggaagatttg 3882301 ctctggggtc aatgtctctg cgttctctga taacgtttga atcagacttt ccaaatatcc 3882361 atttaactct gatttggacg attcatgtag ggattgatga tttacagcga gttctctaaa 3882421 tctgttatca ctgattaatt tttttcgaag agctgctagc atcaagtcaa gccatgcagg 3882481 ctggccaaat gtaatattta aagctaacgt tgcttgatca gatttggtgg agtgccataa 3882541 acctcttggc aaatacagca tggttcccgg tgttaaatta acgatttctg catctggcag 3882601 atcctctttt ggcggatctc ctttccaata tgactgtaaa tcatcaggat agtaaggagc 3882661 ctctgataaa tcatagtgct gcattggatt gctcacattt tcattcttgg caagcttcca 3882721 tgttttctca ccttgaattt gaaaaatcaa gttggtgtag gcgtcaaaat gggctttgaa 3882781 tcccccgcca tttttcgccg cgtaaacaat ggctttggaa gaagtacccg caggcagtct 3882841 taattccgct ttgagttttt ctatccacct tctgacttgg ggaataaata ggtcggtgaa 3882901 atcaaactct aatgcagccc ctttttcata ccactctaaa gcctctgcag gtgacacaag 3882961 aaatctgtct gtgatccctt cagattcttc aatcacagca tcaccaacga ccatgactgg 3883021 attattgtag atagccaata cgttttctag cgttctaacc ttttcaaacc ccggtatgct 3883081 tgtaaatctc tccacttctc ctctggctac caaaggtttt acaggccaat attcttctaa 3883141 aaactcactc atcgttacag gactgatgat agactccaaa accgattcgg ttacagcact 3883201 catattatcc ctcccaaaaa aagtaacttc accacaaaga tataacattt ttttctaaaa 3883261 gtaaatattg acagaattat cagaggatta taatatttag ttgtgcgtga tagcctattt 3883321 ttttacaagg aaggagggaa aaggatgaaa aaggcttata agaaacctcg tctttttgaa 3883381 ctgcgccgtg ctgtagcagc tggcggccat taatctcata tagcatttga catctagtac 3883441 tctattttag gagggatgct caatgaaaaa agcttataag aaacctcgcc tttttgaact 3883501 gcgccgtgct gtagcagctg gcggccatta atctcatata gcatttgaca tctagtactc 3883561 tattttagga gggatgctca atgaaaaaag cttataagaa acctcgcctt tttgaattgc 3883621 gccgcgctgt agcagctggc ggtcattaat cttatccaaa acgattaacg tttgaggcta 3883681 tcacgccaac ttgataagga ggatgctgaa gatgattacg gctgaagaat gcagaacgta 3883741 caaagaattt gttgatcttt accaatccta tctttacccc ttgcttggcg ccagactgtc 3883801 ccggatgtat tcccccaaaa acaaagtcat tatcgatatg ggcacaggtc caggttattt 3883861 aagcattcag ttggctaaaa gaacaaatgc gcacgtgcat gctgtcgata ttaacccggc 3883921 catgcatgaa atcgctcaag aagaagctaa aaaaagcgga gtaagcagcc tgatttcatt 3883981 tgatttggaa gatgtccacc atttatctta cgctgaccaa tatgctgact tcatcgtctc 3884041 ctactcttgc ctgcatcatt gggaagacgt tgttaaagga cttaaagagt gctatagagt 3884101 tctggctccg ggcggaaaaa ttgtcatttt ggatacattt aatccccaag gaagccattt 3884161 agagattatg cgaaaacaaa tcaaagaacc ggaatacttc aggtttgtaa gagaggcatt 3884221 tgaagaaagt tattcctttg aagacattca ccagtttgtt caggatgccg gcattcccaa 3884281 ttattcatta gaaacctttc actttttacc ggaggatttt atagaaagct tagatgagct 3884341 ggaggatgct cccctgtggg aacaaaatga tcaaagtact gatcatgaaa ttgagtctgt 3884401 cacatggatg ttaacgatag aaaaagaaaa ggaaggtgca ttgtaatgat caatgaatca 3884461 actgttttat ccaaaaatcc agaaatgcca tcaagaaaat atttgaaaag cattattata 3884521 gagccgggca tcactttaaa tgaaatggca tcagatattt ataaccatat cgacggcaag 3884581 gtcagcatac atgatatttg ctcaaaaatc gtcaatgaat atgatgttga ttatcaaacc 3884641 tgcttagaag attgtatgga gctgtttgag ttgcttattg atcatgaagc aatcaaagtt 3884701 aagcaggggg catgagaatt ggaaaaacaa aaagtgcttg ctttaccaga cgatgtacat 3884761 gagctgagta cacaccgttc taaatcaatc gtaaattaca tcatcactct gcttgccttt 3884821 gccaaaaaac aaggattgac tcatcaagat attgtaagct ggattcacga gcaatatgag 3884881 gaaagaggat attatgatga gtggagacac attaacagcc aacaaccagt tggatcattt 3884941 gtggaactct ttataaaagg aagacgttta ctttatgaca aaattgaatt gtttgaaaca 3885001 gaagataaat atgtcgtaaa tacccacact tggtatgaaa aagaacctag tgaggccttt 3885061 ttttattttg aaattgatcc cgaagaattt tctgcgtacg cttccattct cgcaatcgaa 3885121 aacgcaaaac gtctcggaat taaaatcgat attgtaaaag aaacagatgt agagacagct 3885181 tatatctata aacatcaata acgctattgg gagggagaca tatgtgcggg ctcgcgggta 3885241 ttataaatct ggctgctccc cgttctcagg aatgtacctt tcatatattg aaaggcatgg 3885301 cagatgccat cagctatagg ggaccggatg atgaacaata tcatattgat tccaaagtcg 3885361 gctttgcatt tcggcgattg tccattcttg accttgtaaa tggacagcag ccctttttaa 3885421 atgaggatgg atcaatcgtc gttatggtaa atggagaaat ttataactat aaagaactga 3885481 aggcttcttt acacaatcat atgtttaaaa cgacatctga ttgtgaagta attgttcatt 3885541 tatatgaaga aaaagggatt ggatttgtag acgacatcat cggaatgttt tcaatagcca 3885601 tttgggacaa aaataaaaac aaagtatttt tagttcgtga ccgctttggg attaaaccgc 3885661 ttttttacac agagctaaaa cacgagctta tatttgcctc tgaaataaaa tccctatttt 3885721 ctcatcctca ctgtccccgc caatttaatt ggaaagaagc actctcagac atttggctaa 3885781 gcggggaagc agccagtaat cataaagaaa ccacttcctt ttttgtaaac atccaaaatc 3885841 tcgatgctgg ccattatctc gaaattaatt tgacaacaaa tgaacgaaaa acagcaagct 3885901 attggtcttt acaggatatt ttgctcaggc aaggctatcg tgagaatctc catcccgatg 3885961 acctgattga aggatataga gaactgctgg cagattcagt ccatagatgt ttacaaagcg 3886021 acgttgaagt cgggttgttt cttagcggtg gcattgattc agctgcagtc gcacattttg 3886081 ctgcagaaaa acaggatctc catacgttta cagtattaag ccaaagtaca tttacaaatg 3886141 aagatgcaaa atatgcccat tggctggcta aagatttaca ccttccaaat catcaggttc 3886201 tctatcaatt agggaacgat gagttattac aaccagagtc atataaacat ttgttatgga 3886261 tctgtgaaac accgttttgc ggaccggaac aattatataa gtttcattta cataagtatg 3886321 ccaaagcgat aaggccaaac ctgaaagtca tgctgaccgg ccagggcagc gacgaattta 3886381 acggcggtta cagcacgaca ctttcaccag ccgagaaccc aagttgggaa ggatttattg 3886441 aatcggtcaa tacgatggag atgaaccggc tgcatcggct gcagggaaat atctttagag 3886501 tgtgggagga gcattttgga ctttctccta taaacctttc ttatttaaag agcaatgatt 3886561 ccagccaagc agatccttgg caatcgtatg tcctgacaaa ataccgtgat ctgcaaatgt 3886621 ataattgctg gcatgaagat cggatcgccg cggctaatca tatcgaaaac cgtgtaccgt 3886681 tcttggacca tcggcttgtt gaatgggttt gcggaatacc tgatggactc cgtaaagact 3886741 tgttatggga taagtcggta ttgcgaaaat cattaacaaa tgagctgcat acaagctata 3886801 cccaccggcc aaaggttcct tttttctatg gtaaggacgt gagatataca cataaaatga 3886861 tgtttcatct tctgaagaaa aacaattatc agcttataga ggaggccttc tctcacagcg 3886921 atgcctccag cataatacag gttgaacaca ttcatgccat catgacatat ttggaggatg 3886981 atcctgagtt tacaaatttt gaatttttat taagactggt gaacatggga cttttatcaa 3887041 aaatgactaa agaaacccct tctgttcaat tagacataac cagccattta gaatcgataa 3887101 caataaaaga ctggcactca caggaaggtg atattgccag tcgtttaaat atctcagcca 3887161 ataagtgtga aggacaagat attttggcgc taaaccctgg cgtcactctg ttaaggccgg 3887221 aaagcgatag tgagcattgc atctacattg cggaagaagg atttattcag tttattgttt 3887281 cggaggaaga cgtcggagct tggctgcata ttctctgcga tattaatgga aaagacacac 3887341 ttcatacgat tttagacaga catggtgtca gccttgaaga agtggccaaa tatattcaag 3887401 aagccatcga acacaatatc attttgatca aacaaaaaaa tctgccagaa ggagcatata 3887461 gatgagcatc ttttattcgt tttccgcact taggggatta gcaatgggga ttttttcgcc 3887521 tatttggatt ctttatctga tatctaaaga ttatgatttc cttcagattg gattaatggg 3887581 agcggtactt gaaattgcta agcttatatt tgaagttcct tccggcgttt ttgctgatcg 3887641 ttatggaatt aaaatttcaa ttgccagttc attctttttc tccatcctta catgggcctt 3887701 cttccctttt atcgattcag ctgctatttg catactggct atgatcatat gggctttatc 3887761 agattcctta atttccggtt cttttgaaac ttggatgagc cgtgtcgcag gggaagatcg 3887821 attcggcaaa gaaatgatga aaaacacaca attgctaatc acttttttaa ttattggaag 3887881 tattgccagc gggtatttgt attcattaaa tatctatttt cctttcctgc tcgttatggt 3887941 gatctactta ttactattta tttggatgtc tgtatttatt aaagtccctt ctgtttccga 3888001 aacaaatcat ggggatcaga accaacatga ttcgataaag attatcaaag aaagtttaaa 3888061 aattatcttt aacaaaaaaa gggttctttt aatcgtcata gccggtttct ttacagccac 3888121 agcctatgac acaatttccc gttactggca gccttttttg agtgatttag gcttttcaga 3888181 aaagtcactg ggatatattt ttgccctagg agggtttacc gctctcgttc ttttgacatt 3888241 aaccatcagg ttcgaaaaga agatcgaaaa aaatccatat ctcgctttaa cctcattgga 3888301 ttccatgggc atggtcatga cttttctatt gtctagagca ttcaggccgc tgggcattcc 3888361 atgtacagcg tttttgcttg caattgaaga tattcatcat ccgatcgtaa caagttactt 3888421 aaataagttt ttccccgatt catacaagaa cacacttttc tcgttaaact caggggtagg 3888481 agcaattgga gaaattcttt ccggtgtcat tttcggcatc atttccgcag cctttgggct 3888541 ctctgccatg tttgttgttg tagctgtatt tctattaatc cctattatcc tttatacgat 3888601 agtgcctaag attaaagaca atgatatgaa agttcagatt gaaaaatccc agcaagtgta 3888661 aatgttttgt atcacagtaa gaagaccttc ttattaaaag aaggtcttct gctattctat 3888721 tcagttattt cccaaaagcc atcagcttcg tataacttcc aatataaagt gttccgtcct 3888781 cagcgagctg aggagaagac acgacgttgc tgtcggtttg atagctccat aattcattgc 3888841 cgtttgcgtc tgccgcataa accttcatat catctgaccc gaaataaacc gttcccttcg 3888901 cgtcaatcag cggcgccgtt ctgacagggc cgtctgtgta gaatgaccag ttcatatccc 3888961 cgtttttgct gatggaaaac agctcgccgc ttcctgagcc gatgtagata ttgccattat 3889021 gatcaatcgc aggagatgag ctggagaacc cgtttagcgg gaatgtccat ttcaaactgc 3889081 ctgttgatgt ataagcatac agctgtccat cttggttgcc ggcataaatg tttccgtcct 3889141 tatcaatcac cggatatcct ttaaacgcat ttgacgtcgt tctggaccat ttcacctgtc 3889201 cggttccgga gttgatcgca taaaacacgt aattatatgt gccgacatac acggtgccgt 3889261 ttttggcaag caccggcaca gagctgacga ccccatttgt tttcaacttc cagcgctctg 3889321 tccaggttga ttttgacgtc ggtttgatcg cgtgaacata attatcaagt gttgagaaat 3889381 acaacgtccc gtctgaaccg atcaccgttt cagagcttgg cccgccgctt aacggaaccg 3889441 ttgttaaaat ttctcccgtt tctttgtcaa taaaataaat ctttttgtca taggatgcca 3889501 aatagataac gccgttggtc ccaagtacag gagattgcgt atatgttttt ccaagattgc 3889561 ccgtcaccca tttgactgag ccgtctggat taaaggcttt catttccccg tctctggaat 3889621 gaagatatac tgtgccgtct ccgtcaatca cagcccccgc tccattttgc ggagtcgttc 3889681 tgatgtcgtt ttgccatttc agcgtcccgt ctgtatttcc ggcgaaccgg ctttcgcgtg 3889741 accagttaaa catggcaggc gccatcgctt gtacatcata tcttcctggc aaaaagccag 3889801 atgctccatt attttgagaa aacaccgttt ccgccgcata agcagctgtc ggctgaagca 3889861 ctttggcagc gggcacatca gaaacagcgc cggccgaaac agccgccgcc accgcagctc 3889921 ccgcaatcaa agctttcata cgaaatgact tgaccatcat tgagaccccc attatatgta 3889981 acttctaatt tgtgaccatc ataacatatt catccatttt ataaatctat ttcacaaaaa 3890041 catcacaaac tagaaaacta tgtaagagta ttcacggacg ttttttcagc acccgatcga 3890101 aatgcagcca caaaccaaat gacgttgaca gcagccgcag cgagactaac tcccaaaaca 3890161 aagatcacct cagaaagcag atggtcacta aagaaactaa acatcaagat aaaaccggcc 3890221 gaagacaaat gaatcaaaag cccgaagccg caaagcaccg ccatgacata cctcattgca 3890281 tcgactccga gcatataaac gagaaatgga atgaaataca agacaaggat cataccgaca 3890341 gctgaccaca tgccagctga attaaactga ttggccgccg ctcccgttcc ggccagcggc 3890401 gaaagtgaag ccgccacaat cacggcgcaa aaaagaaacg cagaaatggt tgtcatgatc 3890461 gccacgctat ttttttttga catcaaactc ctcctttaat agaaatatta acctttttta 3890521 ttataagtaa gttgaatgtt atattcatta tatttttaaa aaattccaga atacatacac 3890581 aaatgctatg cttctttcta gtatatttat atagtaaaaa acaaaggata aaagactcat 3890641 ttttctgtaa tatcaggatt ttatcaccat accatattgc atgtacatgt ttttcaaagt 3890701 atactattcc agattaattc agaggagaga gaaaaataca tggaaaaacc agcaggattt 3890761 tggattcgtt ttttagctta ttttattgac ggcattattg tatctgttcc tagttatatt 3890821 attctattta ttatcaattc tgtgtttgta gctggggctg tggcaacaaa cccttacatg 3890881 acggaagaag agtatttagt gaaatacatg acgcttgcat ttttgcctac tatgctgatc 3890941 atgatcgtca tcagcgtgtt atattacggg ctgctcacag cttctaaaat gcaaggcaca 3891001 cttggcaaaa aaattcttgg cctgaaagtg gtcaatgaac aaggtgaacg ggtttctgtc 3891061 ggacagggaa ttggccgtta ctttgcctat atcttatctg gaatcatctt ttatatcggg 3891121 tttatcatga tcgcctttgg agagaaaaaa ggcctgcatg acatcatttg caaaacacgt 3891181 gtcgtgtata aataatagaa aaaagtctag acgccaatag gcatctagac ttttgttttc 3891241 tttgcaatag gctgccacga cagatacgta gcgcttctcc acaaccactc aaacggcccc 3891301 atccgaaaga cacgaagcca aaggtggctg aagaccattt gaacggcaca aacagcaatt 3891361 gtaatgagca caccggcagc agggtacact tttccataca ggcccaagcc gtaatgataa 3891421 aaaatccaag tacacacaat agactgcatc aaataattgg taaatgccat cctcccaaca 3891481 gcggagaatg attgcagcac tgttctcact cttgttttat gataaagata gacaaccgtt 3891541 gtaacataga aaaacatgag gaaaggcgcg ccaatcagca aacatatttc tttatccgtt 3891601 acactgtaca gcacctgggc gccgatgccg atgacaagcc cagccatcca taatcgtttt 3891661 aatcctttgc gatgcttttc cggttcatgc aaataccgtg attttgctgc cgcagctccc 3891721 agcaaaaaca tgctgaaata tggaatggat gcaaagaagt agttgagcgg attatacgta 3891781 agcatgccat tcgaagacat gtaaacaaga cggtcgtgga tccgctgttc tgcaatatcc 3891841 ttcaggctgc cgcttccata aacatgaatc gcttgttttg cctgctgtgt taccgcttgt 3891901 acccattcct gtccgtttga ttgatcaaaa cttgtcaaca tgaacggaat ggaaaacaga 3891961 agatacaaag agaccgccca tatcagcagt gttttcggct ttgcttttcg aaacaagagc 3892021 aggacaaatc cgagcagggc atattctgtt aaaatatccc cgtcccatat caaaaaggca 3892081 tgaatcgttc caaacaagag aagcgccatt aaccttctca catataacgg aacaaaccgt 3892141 ttccctttgt tttctgctct ctccatcatg acaaccatgc caaatccaaa taaaaaggaa 3892201 aacaataaaa tacattttgt ttgaatgaag aatttcagta tgtctgcggc ggcaaaatca 3892261 gcttcagacc acttatccat gaaaaaattc tcttttccaa gcatagacaa atacatatcc 3892321 ggataactga aatgtgccag attgacaaat aagatgccga aaatcgccat tcctctcagc 3892381 acatcaagca caccgatccg ctcatttgtt aaagtcggct gtaatgaaga catagccatc 3892441 acgctccttt tttctgtacc ttaagggtag gaaaaaatga agcgcggtaa catcgattta 3892501 ggtgtcaggc cggcatgaaa accttacaat cttgtcatct ttatggtttc atcaccttta 3892561 aatctaatgc ttcgatattc tgcaaaatgc gatcaaagcg caaagcctga ggctcacatg 3892621 ggaagatgtg gccttcatac gggtcgccta acgtccggaa aaacggttca aataaaccag 3892681 gaaccaatac gcccaccatc tttgtatagt gagaatcaag gcgataggag tgaacggtat 3892741 ttgcagggac atgcaggaaa tctcccggat tcagctgaat ttcctggcca tctgtccaca 3892801 tcgtcatctg gccttcaagg caataaaatg tttctgtatg atattcatgg tagtgatcaa 3892861 cgattcggtc acctttaggg ccttcagatg atacgacgat aaactggcca tctgtatttt 3892921 tttgtgcagc cacaatgcgg tgaagctgat ctccagtcaa cagacgatct ccttctccag 3892981 attcaagaac gtatggaacc gctccatctg gcagctctgt aagttccgct aatttggccg 3893041 aacatgcagg ctttgcttca tctagaaata caatgtccgc tacagcggct gcttctgcaa 3893101 atcgctcgtt tgagacttct tcgcttgcgt acggcggatg ttcagcgtga tcatacggat 3893161 tcccaataac ggaatacaag tgcgctacgt ttcctttcat cgtgtaagac accagtcttg 3893221 ttctgtggct ctgcatccgg tagctgtgcg gtgttcccgc cggaatgttg gcataatcac 3893281 ctgatattaa taaatagcgt tcaccatcaa gtgtcagttc cagtttcccg tccaaaacga 3893341 gaattccttc atgtgtgtcc ttgtggacgt gaagcggaaa ggcatctcct tttcccccgg 3893401 aaagaagcac gatctcaaac aaatcacctg tgctcctccc attcgccatc accgtggcaa 3893461 cctgtctgcc gaacagatag cgctcgcctt ctccgctccg gagcaaataa ggcatttttt 3893521 ctttaggcaa tgaatgtgta cataatgttt tcatattatc gcttcctcca atttagacca 3893581 gtctatatat tatcattcat ttgtctagac cgttctatat aattgtagga gaaaggataa 3893641 caaaatgcta cccttttttt ctcaccagca ctggtatttg ttcggcaatg agaagaagag 3893701 gcgttttgtc tttattcgtt aacgaaagca tgatgccgcc ctcaatcatc gaattaatca 3893761 gcgttccaag ctgatttgct tcttcttctg caaatccgtt ttccattaat tttctggcaa 3893821 aaaccgcttc ccagctttta aacaccttca tgcaaaccgt ccgcagcggt tcactgatta 3893881 acgctgtctc actcgccagc aaaccgactg gaataccttt aatgctttct gtgttgtcaa 3893941 attggctggc tgtttttttg ataaaaagct gaatcgcttc aacaggatca gaggattcat 3894001 ccatgctttg ctgtatcaga tgttcaacga tcttacctgt atatgtaacc gcttcaattg 3894061 ctagttcttc tttgccattc ggaaaaaagt gataaagcga tccttttgga gcaccgcttt 3894121 cttttacaat ctggttcaaa cctgtcgcgt gatatccttg cagctggaac agacgtgacg 3894181 ccgtgtgaag gattttttca cgtgaatctc ctctgctagt cattaaaaca ttccctccta 3894241 ggtatggtag agcgacttat ataatataaa aaagaaccct gtgattgtca aaaggggtaa 3894301 gacccttccg gatggggtaa tgtacaaaaa cagcgtctag gagggatctc tcaatgacaa 3894361 tcgatcattc agtcacaaat acagagcagc ttgaacaaca gaaccccgcc ataaaaacaa 3894421 agctcaaact gaaaaagctt aaggatcagg tgatcgtcat taccggcgct tcaagcggta 3894481 tcggacttgt cacggcgaga atggcagctg aaaaaggcgc aaaggtcgtg gcagcagcgc 3894541 gaaatgaaga ggcgctgaag gagctcactg atgaacttaa ggaaaaaggg cacgacgcca 3894601 tatgggtaaa ggcggatgtc ggaaaagaag aggacgtcaa ccgcatcgca gaaaccgcga 3894661 tcagcacatt cggccgcttt gatacatggg tcaacaatgc ggccgtctcg actttcggac 3894721 acgccatgga cgtcaccgtc gaagacatga agcgcatgtt cgacacaaat ttctggggac 3894781 ctgtttacgg aacaagagcg gctgtcaaac actacaccgg cagaggtgtg ccgggcgcac 3894841 tcattaatgt aggaagcctg ttcggagaca ggggaacggt cattcaatcc acatatgcat 3894901 ctgccaaatt tgcgcttcac ggctggacgg aaagcatccg aatggagctt gaaaaggaac 3894961 aggcgcccgt ctcggtaacg ctcatccacc cgggcagaat tgacacacca tataacgagc 3895021 atgcgcacag ctacctcgac aaacagccgg ctcattaccg ctccatgatc tatccgccgg 3895081 aagcggtcgc cgaagcgatc ctgtttgccg ccgaacaccc taagcgcgac atgtacatcg 3895141 gctcacaggc caaagccatc gccatgctgg gcgcgctttt tcctcgtctg accgacagac 3895201 tgatggaaaa aatcatgtat cacagccagc atgccgaaag accgtccaat ccgagagaag 3895261 aaagcgctct ttatgatgct ggctgcggta tgcatgacag aggcacaaat aaaggatgga 3895321 tgaggtcaag aagctactac acaaaagcga cgaagcgccc aattgtatcg gcggctgttg 3895381 ttgccggact agtggcttgg gctgccgcca aacgatgcag ataatctctg accataagaa 3895441 aaacccatgc tgttccagcg aaccatgggt ttttcagctg ttaatcgata aaagccttgt 3895501 tcatacgctg cagcagctcg ccgaacatct ctttttcctg tgttgaccat tctttcagca 3895561 tctgttcata acgttcaagg cgcttttgct gatcggcttt taatagttgt ttgccgagtt 3895621 ttgtaatggt aaacaggctg actctcccat cagacgggtc tgagaaacga tagatgagct 3895681 cctttgcctc taatgcagct gcttgtcttg aaagagtaga aatatcaagc ttaaacgatt 3895741 cagccaattc cttaacacga gcaggcccaa actcatccaa ttgtctcagt aataagtacg 3895801 aagatctctc caaattccct gttcttttct ccgattgatc cagataaaca gctctcctga 3895861 taaaagtcgt cagctcatat tcaattaatt caactggatt ttgattttgc aatcgctctc 3895921 gctccctatt ccaatctccg gcattgacaa catcatatat acttgtataa tacaaatgta 3895981 cattaactga ataaatacaa gtcgttatat gactaaatca attattatac ttgtatagta 3896041 caatcatata aaaagaaagt aaagcgattc ctcagaacca tcctagaagc aagcaccaga 3896101 aaggaggaag ctgttctgat tggagagcag cacttgatgt gaaagtcata cgaattattt 3896161 tgcaagtgtt gatattatat gtatttttta tgatcgggga agccattcag catctgtttc 3896221 atttacccgt gtcaggaagc atcgttggat tggtattgct tctgatctgc ttgggcctcc 3896281 gtattgttcc cgtctccatc attgaagacg gagcagggtt tttattatcc ttccttccat 3896341 tgttgttcat cccggcaatg acaggagtga taaactatcc gtctctcatt tcattcaatg 3896401 gcctgatgct gctgattaca gtcgttctca gcaccatcgt cacgatcatt gcggctggat 3896461 tcgccagcca gctattagag aaaaaagcaa aaaaacggga ggagaaagag aaatgcagca 3896521 agcatgtatc gcgatcatta taattctttt aacagttgcc gcttatttag cgatggtcaa 3896581 actctataag cgattcccgc ttccatttct gatccctgtt ctgacaacga caattttgat 3896641 tgtagcggct ttgatgatgt ttcatgtttc ctatgaaggc tatatgatcg gggggaaatg 3896701 gatcaattct ttgcttgggc cggctgttgt ggcgctggcc tatccgcttt ataagcaatg 3896761 gcatatcatt gtcaaacatt gtgttcccat tttaggcggc gtcctggtcg gcttatgcat 3896821 gggaatgatc agcgggctga tcttcgcaga agcattcggg attgatcatg atctcttatt 3896881 atccattctg ccaaaatcga tcacaacccc tgtcgctatt cagatcgccg ccggtcttgg 3896941 cggcgtccct tccatgacag tcgtatttgt catgattgcg ggcttttcag gcgtcatcct 3897001 cgggccgctt ttcctaaaat ggcttcgcat acgcagctcc ctaggacaag gcattgcatt 3897061 aggcagcgcc tcccatgcac tgggtacctc caaagcgttg gaatatgggg aattggccgt 3897121 atccatgagt tccgtctcca tgacgctttg tgcggtgctc ggctcattct tcggcccgct 3897181 cgtcgtctgg ctgtttcata tttaacaaag aaagactgcc ccgggggagg gcagtctttt 3897241 tcgtttaaga agcaaaaaaa tcaatcaacg gctgaaagtc cttagataaa tcaacgtcat 3897301 tcggttctgc ttgaagcagg cggtcaatca tacgctccag ctcctcaaca tcattcttat 3897361 ccgtatattc aatgaagttt aagctttcaa gccaatcccg atatgaatgt ttggctttgc 3897421 catagctgtt tccaaagaca aggcaaggtg ttttggtgat aatcgagaaa atcatcgcgt 3897481 gaaggcggtc ggtaatcacc aatttactgg agccgatgcg gtccagcatc tccataaaat 3897541 gcttttcacg atcagcgtaa tcgatggtgt ctaccgtatc cagcaccgta tcggtacgct 3897601 ctgtgtaagt tgttttttct gcccattgct tcatctgtga aataaaatct tcgtcagtca 3897661 ctttctcctt atccgctctt aaaataaaga gaacgccgtc ccgctcgagc tctcgcggca 3897721 caatatccaa ggaaagcacc atgtccggtg taaagatcac attggagttg aaggtctctt 3897781 tcacaacatc cagtgtttgc gtctcacgcg cagcaatcgt taagtttgta ttttgatggt 3897841 acgcatcctg tgtttttttc ttttccttct gtccttcctc tgtatcctca aaataaacgg 3897901 attgtggcag agaaattgat ttgtagtctt taaacgccga aaagaccttt cttctgtctt 3897961 cctcaatatc gagataaagg tttcctaaat tccctccgcc tgtaaagcag acaatatcgt 3898021 cttcacgaat gatctccttc accagttcaa tgccctcatc cgtcgcataa tccataatct 3898081 caatgtattc ataatacgga aaatgatttt tgataaattt ctcttccgca tacgcaatcg 3898141 cttggtcgcc aatgtttgtg tagctagggg aaccaaacaa aaatactttt cgtttatcat 3898201 ttaacagagc ttccggctcc acatttggcg caatgccttt tactagtttt ttgcctttga 3898261 tttcttgtac agtcatatct gcgtcctcct tctgggatga attcctcatt gtgtgttaac 3898321 tgtctctacc caaaaagaag gatggctatg cattggcatg tgcatcggct atatcagaaa 3898381 catcgttttc gccaatttga tagacgctgc aatgtcccgc gccgttcttt ccatatattc 3898441 cgcggcatgt tcaaacgcgt cttctagtgg cacggctccg gggacgatgc tgaaaagcgc 3898501 atcgattccg tgttgataga cggcattact gtctcgggaa attgatcccg caatgccgat 3898561 aacgggcaca tcgtatgatt tagcggcctt ggccaccccg atcggtgttt ttccatgaac 3898621 cgtttggctg tcgattcgtc cctcgccggt aatcacaagg tctgcatcct gaacgatact 3898681 ttcaaaatca accgcttcaa ggacaatatc aatgcctctt ttcaggtcag cctgaagata 3898741 agttagcagg ctccatccaa gaccgcccgc tgcaccggcg ccctctgtat ctcggaaggt 3898801 tgatccgagc gctttttctg ccatatcagc gaaatggctt acgttctggt ctagtacatc 3898861 caacatgtcg gccgtcgcgc ctttttgcgg cccgaaaaca gccgtagcac cctttggtcc 3898921 tgttaacgga ttgtccacgt cacaggcaac ttccagtttg acattccgca atctggaatc 3898981 aagcccgctc acatctattg atgcaagctg agataacgcg ccgccccctg ggccaatctc 3899041 gctgcctgag ttatcaagaa gccttccgcc caatgcctga atcatcccgg ctcccccgtc 3899101 gttcgtggcg cttccgccga ttccgatgat caatcgctcc gctcccgcat caagagctgc 3899161 tccgattaat tctcccgttc cccttgttgt agtgatgagc ggatttcgct tatctacagg 3899221 caccagatgc agccctgaag cagcagccat ttcaatcaca gctgttctcc catctcccat 3899281 catgccaaag aaagctctca ccggttcccc cagcggccct gtgacaactt gctctatgat 3899341 ccttccattg gtcgcatcga ccagagattg aacggttccc tcgccgccat ccgccaccgg 3899401 caattttctg taatcagcac ccggaaagac cgatttgaaa cctctttcta tcgcttcggc 3899461 tgcctccaga gctgataagc tttccttaaa agaatcaggt gcaatgatga ttttcatcca 3899521 aatcgcctct ttcaaaacat gattcactta acctattgat ctccaatgta ccataattga 3899581 tctggaaata cataccatgc aatatggtaa aaatttaaat aaaaattaga aatgaaagtg 3899641 tttgcataaa agaaatattc acgttatcat acttgtatac aagtatactc cttgagtgag 3899701 gaaggtgagt gtatgctaga ctccaaagac ctgttgtatc ccgcaaaatg gctctcaaaa 3899761 gcgtcaaccg gagttcgtgt cgcatacgag ctgagaatgc ggatcgtttc aggtctgatt 3899821 gaaagcggta ccattttatc agaaaataca atcgccgccg agttttcagt aagccgttcg 3899881 ccggttcgcg aagcgctaaa aatactcgca tccgaaaaaa tcatccgctt agaacgaatg 3899941 ggagcggtcg taattggttt aactgagaag aaaatcgcgg aaatttatga tgtgcggtta 3900001 ctattagaaa catttgtctt tgaacggctt gtcaaaatag acattgagcc tttagttaag 3900061 gatctcagca aaattcttga aatgatgaaa gtctcaatca aatatgagga tgctgacgaa 3900121 ttttcatttc aagatgtgct gttccatgaa acgattatcc gagcgattga tcattcatac 3900181 attcagatga tctggaacaa tctaaaaccc gtcatggaaa gctttattct tttatcgatg 3900241 cgggtacggt taaaggaaaa gtatgaagac ttcacaagga ttttagataa ccacgagctt 3900301 tatattcaag ccatcaaaac aaaggatagg gcgctgatga ttcagtctct tcaccaaaac 3900361 tttgatgatg tgcaggataa ggtagaagac ctatggctct cacaacaaat gctggcaaaa 3900421 ggagctgaat acaacaatga ctagttatat gttaggaatc gatatcggca cgacaagcac 3900481 aaaagctgtg ctgttcagtg aaaacggaga tgtggtacag aaagaaagca tcggctaccc 3900541 gctctataca ccggacatct caacagctga acaaaatccg gaagagattt ttcaggcagt 3900601 catccataca acagcgagaa ttacaaaaca gcatcccgaa aaacggatct ctttcatttc 3900661 gttcagcagc gccatgcaca gcgtcattgc aatcgacgaa aatgacaagc cgctgacgcc 3900721 atgcattaca tgggccgaca acagaagtga aggctgggcg cataagatca aagaggaatt 3900781 gaacggacat gaggtgtaca aacggacggg aacaccgatt catccgatgg caccgttaag 3900841 taaaattgcc tggatcacga atgaaagaaa agaaatcgct tccaaggcaa aaaaatatat 3900901 cggcatcaaa gaatacattt ttaaacagct gttcaatgag tatgtcatcg attactcatt 3900961 ggcatcagcg acaggcatga tgaacctgaa gggcttggat tgggacgaag aggcactgcg 3901021 catcgcaggc atcacgccgg atcacttatc caaactcgtg ccgacaaccg agatctttca 3901081 gcactgcagc ccggaaatag cgatccaaat gggaatcgat ccggaaacgc cttttgtcat 3901141 cggcgccagc gacggcgtgc tgtccaacct cggcgtcaac gccattaaaa agggtgaaat 3901201 cgccgtcacc atcggtacaa gcggtgccat tcggacgatt attgacaagc cgcaaaccga 3901261 tgaaaaaggg agaatttttt gctatgcctt gacggacaag cattgggtta ttgggggacc 3901321 tgtgaacaat gggggcatcg tccttcgctg gatcagagac gagtttgcct cctccgaaat 3901381 cgaaacagcg acacggctgg gcattgatcc atatgacgtg ctgacgaaaa ttgcccaacg 3901441 cgtcagaccc ggttctgacg gtctgctgtt ccacccatat ctcgccggag aacgcgctcc 3901501 gttgtggaat ccggatgtac gcggctcatt tttcggcttg accatgtcgc ataagaaaga 3901561 gcatatgata cgcgcggcat tggaaggcgt catttacaac ctgtacacgg tgttcttggc 3901621 gttaactgaa tgcatggatg gcccggtaac ccgcatccaa gcgacagggg gttttgcaag 3901681 gtcggaggtt tggcgccaaa tgatgtcgga tatcttcgaa tcagaggttg tcgttccgga 3901741 aagctacgaa agctcatgtc tcggcgcctg cattttaggc ctgtatgcaa caggaaaaat 3901801 cgattctttc gacgccgtgt ccgatatgat cggcagcaca tacagacata cgccgatcga 3901861 agactcagcc aaggaataca gaacattaat gccgattttc atcaatctat caagattatt 3901921 agaaaatcaa tatacacaaa ttgcagatta tcagaggggc ttaatcacac acaaatagta 3901981 catgacatga aggggagggc attaccatgc cgttaatcat cgttgcactt gggatcttag 3902041 cattactatt tctgattatg ggcttaaaat taaacacatt tatttccctg ctggtcgtat 3902101 cgttcggcgt ggcactggca ctcgggatgc cgttcgataa agttgtcagc tccatcgaag 3902161 caggaatagg ggggactctt ggccacatcg cgctcatctt cggactcggt gcgatgctgg 3902221 gcaaactgat cgcggattca ggaggcgcac agcgcattgc gatgacgctc gtcaacaaat 3902281 tcggtgagaa aaatattcaa tgggccgttg tcattgcctc attcattatt gggattgcgt 3902341 tattttttga agtaggactg gttctattaa ttccgattgt ctttgcgatt tcaagagaat 3902401 tgaagatttc tattttattt ctcggaatcc cgatggtcgc ggcactatcc gtcacacacg 3902461 gtttcctgcc gccgcacccg ggacctacgg cgatcgccgg tgagtatggc gcaaacattg 3902521 gagaagtgct gctgtacggc tttatcgttg ctgttccgac agtgctcatt gcagggccgt 3902581 tatttacaaa gttcgcgaaa aaaatcgttc ctgcatcatt tgcgaaaaac ggcaatattg 3902641 catcactcgg cacacaaaaa acatttaacc ttgaagaaac acccggcttt ggaatcagtg 3902701 tctttactgc aatgctcccg attatcatca tgtcggtcgc gaccattatc gacctgcttc 3902761 aagaaacaat cgggtttgca gataacggag ttttagcttt tatcagattg attggaaacg 3902821 catcgactgc tatgattatt tcgttattgg tcgcagtcta tacaatgggc atcaagcgca 3902881 acattccagt caaaaccgtg atggattctt gttcaactgc catttcacaa atcggcatga 3902941 tgcttttgat catcggagga ggcggcgcct tcaaacaagt gctgatcaac ggcggtgtcg 3903001 gcgattacgt agcagactta ttcaaaggaa cggcattatc gccaatcatt ctggcatggc 3903061 tcatcgcagc gatcctgcgc atttctctag gatcggcgac tgttgccgca ctaagcacaa 3903121 caggtctggt cattccgtta ttgggccatt ctgatgttaa cctggcgtta gtcgtactcg 3903181 caacaggagc cggaagtgtc atcgcttcac acgtcaatga cgccggcttc tggatgttca 3903241 aggaatactt cggattaagc atgaaagaaa cattcgccac atggacattg ctggaaacca 3903301 ttatttccgt tgctggactg ggattcattt tattgttaag tttagttgta tgaaattaag 3903361 aaggagctgt aacacatgtt caattcgatt ggtgtcatag gcttaggcgt aatgggaagc 3903421 aacatcgcct taaacatggc aaataaaggc gaaaacgtcg ctgtctataa ttacaccaga 3903481 gatttaacgg accagcttat ccaaaagctg gatggacaat ctctcagccc gtattacgag 3903541 cttgaggact ttgttcaatc gttagaaaaa ccaagaaaaa tctttttgat ggtcacagcg 3903601 ggaaaacccg tagattccgt catccaatca ttaaagcctt tgcttgaaga aggcgacgtc 3903661 atcatggacg gaggaaactc ccactatgaa gacacagaaa gaagatatga cgagctgaag 3903721 gaaaaaggga tcggctacct gggagtcggc atttccggcg gtgaagtcgg tgcgttaaca 3903781 gggccttcca tcatgccggg cggagatcgc gacgtctatg agaaagccgc tcctatcctg 3903841 acgaaaatcg cagcccaagt cggagatgac ccttgctgtg tctatatcgg accaaaaggg 3903901 gcagggcact ttacaaaaat ggtgcacaac ggcattgaat atgccgacat gcagctgatt 3903961 gcagaagctt atacgtttct aagagaaacg cttcgtctgc cgctagatga aattgcatct 3904021 atttttgaaa catggaatca aggtgagctg aaaagctatt taatagagat tacagctgag 3904081 attttacgca aaaaagacga aaaaacagga cagcctctga tcgatgtcat ccttgataaa 3904141 accggccaaa aaggcaccgg aaaatggacg agcatgcagg cgattgataa cggcatcccg 3904201 tccacgatca tcacagagtc cttgttcgcc cgctacttgt catctttaaa agaagaacgg 3904261 atggcagctc aagatgtatt agcaggcccg gaagccgaag aaaaacactt ggataaagac 3904321 acttggattg aatacgtcag acaggctctt tacatgggga aagtatgcgc ctatgcacaa 3904381 ggctttgccc aatataagat gtcatctgag ctttacggct ggaatctgcc gctcaaagac 3904441 atcgccttga ttttccgagg cggctgcatc atccgcgctg atttcctaaa cgtgatcagc 3904501 gaagcattca gtgagcagcc aaatctggct aacctgctga tcgcgcctta tttcacagat 3904561 aagctccatg cctatcaaac aggcctgcga aaagtcgttt gcgagggtat cagcaccgga 3904621 atctctttcc catgcttaac taccgcgctc tcttattacg acggctaccg cacagggcgt 3904681 tccaatgcga acctcttgca ggcacagcgc gattactttg gcgctcacac gtacgaacgg 3904741 actgatatgg acggcgtctt ccatacgaat tggtctgaat aacctgtatt aaaaacacgg 3904801 tcagtttcaa ctgaaccgtg tttttttctt ctatcccaaa caacagaaga cataagttat 3904861 gttttaaata tcataaacag tgatacaata atagctagaa acaatcccca agatcatcat 3904921 gtgacagcag attgctgttc cgttctattc tgcttttggc cattgtcctt tgcccttgac 3904981 catggtgtca taaaatgttc aaatgccaaa acggcctggc attctgattt acaaaagtcc 3905041 ctgaaaacct tatctaattg agaatcagcc tctcatttat tataaaagaa atgcctaaat 3905101 cctacctgtc acacctttat taagatgaaa aaaagtaggt tatggcttga caaaaaatat 3905161 atattaatta ataattcata tataattaga attattattg aaagcgatta tgctttctaa 3905221 tacattttta ggaggaatat acattatgtc tttaatcggt aaagaagtac ttccattcga 3905281 agcaaaagca ttcaaaaacg gtgaattcat cgatgtaaca aacgaagatt tgaaaggcca 3905341 atggagcgta ttctgcttct acccagcaga tttctctttc gtatgcccaa ctgagcttga 3905401 agatcttcaa gaacaatatg ctgcacttaa agaattaggt gttgaagtat actctgtttc 3905461 tacagatact cacttcgtac acaaaggctg gcatgacagc tctgaaaaaa tcagcaaaat 3905521 cacttacgca atgatcggtg acccatctca aacgatctct cgcaacttcg atgttcttga 3905581 cgaagaaact ggccttgctg accgcggaac attcatcatc gatccagacg gcgttatcca 3905641 aactgttgaa atcaatgcag gcggtatcgg ccgtgacgca agcaaccttg taaacaaagt 3905701 aaaagcagct caatacgttc gtcaaaaccc aggtgaagtt tgcccggcta aatgggaaga 3905761 aggcggcgaa actcttacac ctagccttga tctagtaggt aaaatctaag gagtgcattc 3905821 aattggtact tgatgcaaat atcaaagcac aattaaatca atatatgcag ctaattgaga 3905881 atgacattgt tctcaaagtt agcgcaggcg aagatgacac ttctaaggac atgctggctc 3905941 tcgttgatga gctggcttcc atgtcatcga aaatttcagt tgaaaaagct gaattaaaca 3906001 gaacgccgag cttcagtgtc aatcgtgtcg gagaagacac tggcgtgact ttcgccggta 3906061 tccctctggg ccacgaattc acatcattag tgttggcgtt gctccaagtg agcggcagac 3906121 cgcctaaggt agaccaaaaa gtcattgatc aggtgaagaa gatcagtggt gaataccact 3906181 tcgaatctta tatcagcctg acatgccaca actgtcctga tgttgtacaa gctttaaaca 3906241 tgatgagcgt gctgaacccg aacattacgc acacgatgat tgacggtgca gcatacaaag 3906301 cagaagttga aagcaaaaac atcatggcag tgccgaccgt ttacctgaat ggcgaatcct 3906361 tcggaagcgg ccgtatgacg cttgaagaaa ttcttgcgaa aatgggcagc ggcacagatg 3906421 catctgagtt tgctgacaaa gagccgtttg acgttcttgt ggtcggaggc ggacctgctg 3906481 gtgcaagtgc agcgatctac actgcacgta aaggcatccg aactggtgtt gtcgctgagc 3906541 gcttcggcgg acaggttctc gacaccatga gcatcgaaaa cttcatcagc gtcaaagcga 3906601 cggaaggacc gaagctagcg gcaagtcttg aagagcatgt gaaggaatat gatattgatg 3906661 tcatgaacct tcagcgtgcg aaacgccttg agaagaaaga tctgttcgaa cttgaactcg 3906721 aaaacggcgc tgtcctgaaa agtaaaacag tgatcctttc aacaggtgca cgctggcgca 3906781 atgtcaacgt ccccggtgaa caagagttca aaaacaaagg tgtcgcatac tgcccgcact 3906841 gtgatgggcc attgtttgaa ggcaaagacg ttgcggtaat cggcggcgga aactctggta 3906901 tcgaagcagc gattgatctt gcaggtattg tcaatcacgt tactgtacta gaattcgcgc 3906961 cggaactgaa agcagacgaa gtcctgcaaa aacgtctcta cagcctgcct aacgttactg 3907021 tcgtgaaaaa cgcacaaaca aaagaaatca caggtgatca gagtgttaac ggcatcacat 3907081 atgtagaccg cgaaacaggc gaagaaaaac acgttgaact tcaaggtgta ttcgtccaaa 3907141 tcggtctcgt gccaaacaca gaatggttag aaggaacggt tgaacgcaac cgcatgggcg 3907201 aaattattgt cgacaaacac ggcgcaacaa gcgtaccagg cttatttgct gccggcgact 3907261 gcacagacag tgcgtacaac caaattatta tttctatggg atcaggtgca actgccgccc 3907321 tcggcgcgtt tgattaccta atccgtaact aatataagaa atccgctata ttgccagatt 3907381 ggcaggatag cggatttttc tttttctaca gaaaaaaacc gaaccaggca ctacggtaaa 3907441 agtgctcgat tcgagcgctt cttatagttc ctcaccattc gtttgaatga catttttata 3907501 ccactcaaag gagtctttct tatatcgttt catggatccg tttccttcat tgtcacgatc 3907561 aacatagatc atgccgtagc gttttttcat ttcgccagtt gtgaaggaga caatatcaat 3907621 aatgccccac ggcgtgtagc caattaaatc aacaccatcg tacgtgaccg cttttttcaa 3907681 tgcttcaata tgcgatttta aatattgaat gcgttccgga tcatgaacct tgccgtcctc 3907741 ctccagcgta tccactgcgc caaagccatt ttcaacgatg aataacggga tttggtatcg 3907801 gtcataaaaa cgatttaacg tatatctcaa cccggttgga tcaatcgccc atccccagtc 3907861 actcgaagtg atgtacggat tttcgacacc attcggcaag ccgccattta caatatcgcc 3907921 agtgttatca tttttcacat cgcttttcac agttgttgac atgtaatagc tgaagcctaa 3907981 gtaatcgacg gttccgtttc ttaaaatctc atcatcgccg tcttcgaatg tgatgttgta 3908041 gccttcgcgt tcaaattcct tcaacgcgta gcttggataa taaccgcgaa cctgcacatc 3908101 agggaagaaa tagcgctgcc tcatttcttc ttcagccagc atcacatctt caggattgga 3908161 ggagaaagga taaatcggca cgtgtgatac catggcccca atctggaact ctggattgat 3908221 gtcttttcct tttgccactg ctaaggcgct cgccactaat tcatggtgcg ccgtttgata 3908281 catgacttcc ttggcgtttt cgttttcgcc aaccacaaca cctgaattcg tccataggaa 3908341 cagcggattg ttcacatcca tttggttgtt aatctcgtta aatgtcatcc agtacttcac 3908401 tttatctttg taacgggtaa agcaagcctc tgcgaagttg acgaagaagt ccacgacttt 3908461 ccggtttctg aagccgccat attctcttgc caggtgcagc ggcatttcaa agtgagacag 3908521 ggtaatgacc ggctcgatcc catgcttcag caattcatca aacacatcat cataaaactg 3908581 caaaccagct tcgttcggtt cagcctcatc gcctttcgga aaaatccggc tccagccgat 3908641 ggacgtccgc agacatttta atcccatttc cgcaaacaaa gcgatatctt ccttgtatct 3908701 gtgatagaaa tcaatggctt catggtttgg ataaaattcg ttttcttcaa tcgtgtcagt 3908761 gatttttctc ggcacgccgt gcgcacccgc tgtcatcaca tcgacgacac tcggcccttt 3908821 accgccttga ttccatccgc cttcaaattg gtgggcagct aaagcaccgc cccataaaaa 3908881 atcctttggc atgtttccca tgtttaattc ctcctcagct tacgactgta aatatttttt 3908941 gatgtaatgc actttcctca atgtcttcaa tgaaagcttt atcaaactca acaagcactt 3909001 cgcctttttt gacggtatcg ccttctttta ccttcaagga aaaaggcgtg ccgtcaaatg 3909061 tcaccgtatc cagcccgatg tgcgcaagca attcgacgcc ggacgctgaa cgcaggccaa 3909121 tcgcatgctt tgtaggcgta accatgacaa ccgtaatgac gccgggatgg tagcatcgat 3909181 ttcacgatat ccttcgcttt aggggtagac cgcttcagca ccaatcgaag tctggtagcg 3909241 cagcgagaag ccccaatcac attctcttcc ccgcctacgg cctctaaaat gtcttttgct 3909301 agtctcgtat aatctctcac tttccccgac atttcaccca ccccttcgtt ttggttacgc 3909361 tttcattata attgtaacgg tataatttat caattccgaa acaaaatatt tacgcactaa 3909421 ctatcattgt aagcggttta tgctataatt ttgacaagtg aaactaaacg aataaatgag 3909481 gaatgcgtat gttaaaatac cagcaaatcg caacggaaat tgaaacatat atagaagaac 3909541 accagcttca gcagggagac aaactgccag tcctagaaac cctcatggcc cagtttgaag 3909601 tcagcaaaag caccatcaca aagtccctcg agctattaga gcaaaaaggc gcgatctttc 3909661 aggtcagagg aagcggcatt ttcgtcagaa aacataaacg aaaaggctat atcagccttc 3909721 tgtcgaatca gggatttaaa aaagatctcg aggatttcaa cgtcacctca aaagtcatcg 3909781 aactggacgt gagaaagcca acaccggaag cggcggaaaa cctgaacatc ggaatggacg 3909841 aggacatcta ctatgtcaaa agggtccgct acatcaacgg ccagaccctt tgctacgaag 3909901 aatcctatta caccaaatcc atcgtgacgt atttaaacaa cgaaatcgtc tcccactcca 3909961 tcttccatta catccgggaa ggactggggt tgaagattgg tttttctgat ttgtttctgc 3910021 acgtgggcca gcttaatgag gaagaagcgg aatatttggg attagaggct ggactgccga 3910081 agctgtatat agaaagtatt tttcacctga caaatgggca gccgtttgat tactcgaaga 3910141 tttcgtataa ttatgagcag tcgcagtttg tggtacaggc taatagtttt ttattatagg 3910201 gctcttcact acggtaggtg gtcgacatgt acaaaattat cattcctgcc atactagcca 3910261 tctttgcgct ctggatactc ttacagattt cactagagat gagcatcgtt aagaatccaa 3910321 tgaactactt tatcgtattc attatctttt tcctctttgt aaagatggtg aaagaaaaac 3910381 aataatagtt tgggcgatgc aaacagaaaa acatccttcc cttaacaaac tcagccagtc 3910441 acatgcatta atcttgatgt taatgatata taggtgcaca taaaaagcta cttcattgtg 3910501 aagtagctcc ctttattaaa ggcccatttt gatccatcta gttttagaaa agcgaaggac 3910561 aatcgcattt atgataataa ttgaaactaa atacaaaata ataaataaaa catcattact 3910621 cccaagtgtc atgttatcag attgcagcac tctttctatt cgggggtaca tagtgttacc 3910681 tgcctcaaaa ggagcaatga aaccaaacgt tttattgctt atagctacta agataacaga 3910741 agtcatccaa taaacgatac tgacacctat actaattaat atattaggac ataacacgct 3910801 tatagttccg ataattagaa tatactgcag tataactgca gaaaataaaa aaagtaataa 3910861 tgcaaaatgc gaaaaatcat ggtacatcaa cgatatgatt agcaggccta gcgttataaa 3910921 tgcaaaacat tctaaaaata aaacagctat ctttttataa aagaaagtat agatgttctc 3910981 tccaattaac ttgtaaaaga gaatattttt gtttgaatac tctctattaa taaagaaagc 3911041 tataacaaat gaaaataaca tcaaaccaaa ctgggtcgca acagtatagg agctaaagaa 3911101 aaacatttca ggtgtaacat tactgacttt atcgattcca acaagtaaaa aataacccag 3911161 caaaaataaa aatacaaaca ttgctcctaa aataatgata actttgttgc taatactctt 3911221 tttaaactct aatttcatct caagccccca ctgttttatt actcatttat atacacttca 3911281 attaatttat ccactgaatg atattgttga atttcttggt gattaaatat ataataatcc 3911341 ccttctatcg cctttaaatc agacaaatca tgtgtaatgt tgatgataat cttctcgggg 3911401 ttctcctgaa tatacttgtt taagaagcca tgaatctcta taaccgtttt tttgtctaat 3911461 gaattcgtta tttcatctaa aacaataata tttttatcct ctaataagaa actgagcaat 3911521 tttaattttt gcttttgtcc atcactcaaa tttttgatca gaacttttcc atcaatatta 3911581 tccagattaa gtaaatatgc gattttatct atcatttttg catcaaattt tttactcaaa 3911641 aagtgtaata aaaagtcctt agaaacatca ttaggtatat tcgacgagct ggatattaaa 3911701 gaaacatttt gacgaatatc tctgccgatt cttttgctat tattcaacaa aaagtcttta 3911761 gcaagctgtg atttaccgac tccatttttt ccgacaacgt gattaatttt cccgctcgaa 3911821 aaatgcaagt cggtgtcctg aagtaacgtt ttgcctttca cttttaaagt gtaattcgct 3911881 atattcatat acatactcct aggaaatatt tgcataataa taaaatgttc tgccttgtga 3911941 tttgttacta atgtctaagc ttttgaggta cctctttcgt ttccgatccg gaagcgaaag 3912001 aaatgttttt agatggctaa tttggagatc ttttactcta gtttacaata tataatatcc 3912061 aatgtacaac tgaattcact gcaaggccaa tccctataat ttgaatcgta agaactaacc 3912121 aatgatttgt cttaaaacgg ctatattcat ctaagctcag aaaagctaaa agaattttgt 3912181 aaccatcaga attcaatatt gggattaagt tccacaataa agtagacgag aaaagcataa 3912241 atgccatagt taatgcttca ctggaaaatg taaattgatt tattaattct aatgtattta 3912301 ttaaaagata attgataaac aagccaaata aatgaacgat tatcttttca tttcttgata 3912361 gcatgtaggt ttcattcaat tggacataaa aagcaggaaa tacataaaaa ttcagtttga 3912421 atcccacttt atcaaagttt ttcccgaaaa attttaagga ataaatatgt cccagttcat 3912481 gaagcactat attcattata aaataaataa ctataattat ccacattttc cagccgtaaa 3912541 atactgagga caatccattt tgcaatttta ttaaatgaat ataatttaat atgaacatga 3912601 gagccgtaaa ggataagaac agataaaaaa actttggtga tactttctct ttatacattt 3912661 taaaacgtaa taattgttta tctgacagag aatttaaact atttttatag tattctccgc 3912721 tttttttgtc ttttataaat acgttgtttt gcacaagcac ttcatatttt tcatcttcat 3912781 actttaaaat tttcattata gtatttttcc atataaggat agaagtagtt tattttttct 3912841 gcagagttga ataaggaacc acaaactcca caaatagagg aaaattcata aggaatgtca 3912901 aattcctcta ttttgttatt ttcttttaaa atattcaaaa accatttgaa tccttctttt 3912961 ctaagaataa ataatagcaa attggaattt aacttttcca cggttctttc gaaactttgg 3913021 ttatattctt cccttagggt tattttcgtt tcaaaaatag caggggaaca acatggataa 3913081 atttctccat catgatgata tacaatgtca tatccgggac aatgtaagga atcttcatct 3913141 tcaagactgt aaaatttatg tatgttttct tgcttaattc tagttttagc agcgccaact 3913201 gatatcattg gaaattttgt tatctttaca cctaagattg aatcccccaa ttcctctaaa 3913261 atgtggttgg acattttgtc tttggtaact gccatattaa gagaaatatc gatatcaggg 3913321 tatttcctgc tatgttctaa tatgttttta atactggaag acttgacaaa tggagcatgg 3913381 tactcatcat aacttatagt cagtgctatc acatttaaag aattcatatc atgaaagtac 3913441 tcctggacct ttttcttgct caaaccccaa aatccattag agatcaacgt tatttgtttt 3913501 tcatatggtt taatgatttc cattagttct tttaaaaatt tataatctaa aaaaacttcc 3913561 ccacctgtaa aagaaatcac ttgaatggtt ttgttttttg caaattcagt tactaactct 3913621 cttatgtatt ctttttccat cctggttgtt gaagttggtg aactagaaaa acaacaatgg 3913681 tcacaggatg cattacacct tgaatctaaa ttgattgata ctgttttatt atacatgaaa 3913741 tatcccccaa caaatggtaa aggagagtta gactctcctt tgtacccctc taattaatga 3913801 ccacttccaa gaatccagcg attttctttt gattttacaa aataccaaag atcattcact 3913861 tttgctaact tttgtgattc atctaataga cccttaaatt ctaagttttt cacagtctca 3913921 ttgttagtga tttccttttt catattatcc ctcctccttt tctaatataa accaattatt 3913981 ctatatcatt caatacatgt caatatattg tacctaaaaa atctgaaaaa tgtcactatt 3914041 cttggtatat aaagcctata gtcctctagc ccctctaagc tataccgaat gaaaggccat 3914101 agtttgattt aaagcttcgt aatgaaaagt aaaacatcaa tattgactac actagttaag 3914161 ggatatacag attttaagtg gaagaaatga ggcaaacaat cttaccctaa accaacctgt 3914221 actgaaaagc tgttttaagc tcttgcttac cccatttggc acctctttct ctcgttttaa 3914281 ttgtctctaa aagcagttat gcggtactat catataaagg tccaatgttt aaaaataatg 3914341 tcatactttt aaattcacct tatcatgcac atgctcataa agaggggttt attctaaaaa 3914401 ggggatggac ggttttggaa agcaagtacc tagatctact cgcacaaaaa tacgattgtg 3914461 aagaaaaagt ggtaacagaa atcatcaatt tgaaagcgat attgaacctg ccaaaaggca 3914521 ccgagcattt tgtcagtgat ctgcacggag agtatcaggc attccagcac gtgttgcgca 3914581 atggttcagg acgagtcaaa gagaagatac gcgacatctt cagcggtgtc atttacgata 3914641 gagaaattga tgaattagca gcattggtct attatccgga agacaaactg aaattaatca 3914701 aacatgactt tgatgcgaaa gaagcgttaa acgagtggta taaagaaacg attcatcgaa 3914761 tgattaagct cgtttcatat tgctcctcta agtatacccg ctccaaatta cgcaaagcac 3914821 tgcctgccca atttgcttat attacggagg agctgttata caaaacagaa caagctggca 3914881 acaaggagca atattactcc gaaatcattg atcagatcat tgaacttggc caagccgata 3914941 agctgatcac cggccttgct tacagcgttc agcgattggt ggtcgaccat ctgcatgtgg 3915001 tcggcgatat ttatgaccgc ggcccgcagc cggatagaat tatggaagaa ctgatcaact 3915061 atcattctgt cgatattcag tggggaaatc acgatgtcct ttggatcggc gcctattccg 3915121 gttccaaagt gtgcctggcc aatattatcc gcatctgtgc ccgctacgac aacctggata 3915181 ttattgagga cgtgtacggc atcaacctga gaccgctgct gaacctggcc gaaaaatatt 3915241 atgatgataa tccagcgttc cgtccaaaag cagacgaaaa caggccagag gatgagatta 3915301 agcaaatcac aaaaatccat caagcgattg ccatgatcca attcaagctt gagagcccga 3915361 ttatcaagag acggccgaac tttaatatgg aagagcggct gttattagag aaaatagact 3915421 atgacaaaaa tgaaatcacg ctgaacggaa aaacatatca actggaaaac acctgctttg 3915481 cgacgattaa tccggagcag ccagatcagc tattagaaga agaagcagaa gtcatagaca 3915541 agctgctatt ctctgtccag cattccgaaa agctgggccg ccatatgaat tttatgatga 3915601 aaaaaggcag cctttattta aaatataacg gcaacctgtt gattcacggc tgtattccag 3915661 ttgatgaaaa cggcaatatg gaaacgatga tgattgagga taaaccgtat gcgggccgtg 3915721 agctgctcga tgtatttgaa cgattcttgc gggaagcctt tgcccacccg gaagaaaccg 3915781 atgacctggc gacagatatg gcttggtatt tatggacagg cgaatactcc tccctcttcg 3915841 gaaaacgcgc catgacgaca tttgagcgct atttcatcaa agagaaggaa acgcataaag 3915901 agaagaaaaa cccgtattat tatttacgag aagacgaggc aacctgccga aacatcctgg 3915961 cagaattcgg cctcaatcca gatcacggcc atatcatcaa cggccataca cctgtaaaag 3916021 aaatcgaagg agaagaccca atcaaagcaa acggaaaaat gatcgtcatc gacggcggct 3916081 tctccaaagc ctaccaatcc acaacaggca tcgccggcta cacgctgcta tacaactcct 3916141 acggcatgca gctcgtcgcc cataaacact tcaattccaa ggcagaagtc ctaagcaccg 3916201 gaaccgacgt cttaacggtc aaacgattag tggacaaaga gcttgagcgg aagaaagtga 3916261 aggaaacgaa tgtgggtgag gaattgttgc aggaagttgc gattttagag agtttgcggg 3916321 agtatcggta tatgaagtga ggggtgtggg gttcagggat ggtgatatgc tgctccccta 3916381 aaagtagata gatgaatttt agaaaatctg tttgccttgg ggagtttttt catggctgga 3916441 caattatact acaaggaaga aatactaata cttatagaat gtaattgggt aatgattcgg 3916501 agaaagaggt tgcgaaataa tatggtatta cactgaaaca attatcaatg gagaacatgc 3916561 acgatatagc cgttctatat tctccctcta ttatggcact cattagtaga cataaccgta 3916621 aaaaaatgca ctcaaaaaaa gtccattcta tataactctc gctagggtgg acctttttca 3916681 acattcaaag tactagattt tttctagtga aagaataaga aaagacataa gttctatttt 3916741 atcactctgt tataggttaa gttattacgg tgtttcatta tatactgaat ttaaacaccc 3916801 ttgacattat gggaattttt aaaacaggtt aaaaggaagt tctataagaa ctccctagtt 3916861 taatattatt tggtcaaaat ctaaaaccaa aaaatctatt tttatcttca ttgtttctat 3916921 ctaattttgc aacaatcata cctttcgact ctaattcttg aaggtcatct aataataatt 3916981 catttttatt tattgttaca aaatattgtc cgatcctatt ctctaacaga cttgaattga 3917041 tatgttttaa taatgtacct tttacatgag gatcaggatt agaataagat ccgtcatgaa 3917101 ttaaaatatt caaactacac ttatttatac acctgtataa aaaccaagta agatcaaata 3917161 tatttatctt catatggagt ctaccatgtg aacgttcatc cggtatagaa caagaaattt 3917221 tgatccttcc tgtagttgat tgttttgcgt tacttattct attatcatat tcaaaatcta 3917281 aaaatccatg ttggttgtat gtaacatcca ttagattatt aaaaagcttc tttaactcac 3917341 taactatagc gctataagat tgaaactcat cataatacat tgaattaact cttaatattt 3917401 catgttgaag ttcattaatc ttatcaaaaa tatggttttt tttatcgtag tcactaattc 3917461 tcaatcttac ttccgctaac tctatttctt tccttctttg ttcttccatc acaatggaaa 3917521 tatcctcaat gaaattgtta ctctttaaaa ttctggcact tgattccagt tgttctgtta 3917581 atccttgctt tttgatatta agttttttta aatcggcttg tattttaaca attttatctt 3917641 taaaataact ccctctactt tctaccatga aattatagaa ctcttggact ttattataat 3917701 tctgttttac ttcctctgga aaaaaaccta caatatcttc atagaatttt tctatatttt 3917761 ctaattcttt aatcttagtt acttttttat ttaaatcatc tatatttctt tgatattgtt 3917821 tacaaatatg ttcattttca aatatttcat tttgtatttt attaagttca cttttaattt 3917881 ctgagtacct atttgtatca ttattatatt tattggcagt cttagtttga tagataactc 3917941 tattgtaatc ctctatctca tttattaatt catcttcctt aacttttaaa tcgccaatgt 3918001 taatattcat tgattcaatc aattttattt cactatttaa tttttcaatc ttatcccgaa 3918061 aaacctttat gtttttttct gtatgagttg gtaaagtaaa aagatagtta agtaatttat 3918121 attgttttaa ccctccccta ttcggtaaaa ctatatcatt aaaccctgtc ttttcgtctc 3918181 ttataatata ctcccttaac gccgcaaaag ttatatcctc tttctcaccc tttaaaattt 3918241 ccttttcaat aaatttttta tatacactta tactaacttt tttccattcc tccaaattaa 3918301 aagttaaaga agtatcatgt aatgtataac catgtttagg agaattaaaa gatctagcaa 3918361 ggaatacttg atttccatca atttccacat tcaaaacaat aaaaacgttt ttattgagaa 3918421 gaatttcatt tgtcgtataa aaatttgata tagtcttccc tagtaaaaag gagatgcatt 3918481 caatcatcgt tgacttacct acaccattag tctcttcatg atcttctctc ttttcaccaa 3918541 gtattatatt tactcctaca gcattaaatt tatactcttt caaaatttct tgggaattgc 3918601 aaacaaaaag attttttata atcataacaa tcactaactc tccgttctgc taatcatatt 3918661 ttgattaaaa gaaactttac ctaatgaata taaaaaagtt aacgataaat acagtatccg 3918721 ttcaatattc aaatttatta taataccttg actcttagca taatcaagaa aaagttgatc 3918781 aatatgtttt tccttctcta acagttcata aagtatcttt gatgagtata aaatattttc 3918841 ttccacagca ttatatttag ttaataaaaa atgattcatt tctggcctct ccgccttttc 3918901 cttttttaaa ggagaattat tcactagagg aataagatca tttccaattt gaatgttttt 3918961 aaactcattt tctaataaaa cataagagta tttgagaata ttttcagctg tttcaatttt 3919021 aagatcaatc attcttaaca cttcttttgt tatcattaaa aatctcacat tcataaatgc 3919081 accaacatgt taaaatctta atgtattttt tcgttaaagc ctttgaatat ggtaaaactg 3919141 aatgacattc tagataaatc tcattaacaa tttttacaaa tatctcatct ccattattat 3919201 attgattatg aaactctaga tatttgtcta ctatcgtctc agcaatcaat tcctttttat 3919261 cagcacttac atacgaagtg gaatccatta tatggtttat cacaccaaaa tactcagaat 3919321 aactatcgaa tttccgttta aaagtttccc cacttttcat atcataaaat tttttatcta 3919381 aaccaatttg attatcaaaa ttactagtaa atgttttata actttctcta tactcatgaa 3919441 aatctataat aaagctctta aactcatctt catcaatttt atcatcgtta tcttctattt 3919501 ctttttcaat aaggctctct aatctattaa tcttataatt taacttccct tcctgtagtc 3919561 tccttcctcc ttggttgttt tttgaccagt atttatattc ggtattccaa atgtagtatg 3919621 ttacttctgt ctcgccatta tctaaattca catccaccga aataaattct ggagtagcat 3919681 actcatcctt tataatggct ccacttacta attctaagaa tggattttca tttgtatttg 3919741 cagtaatatt aaatgaagaa tcatgtacat gtcctgccaa atatagatca ataaagtaat 3919801 catcaaaatg tgcctttatt gattctcttt cggaagattc aatacaacct aacgtatggt 3919861 gcccaatagc tatatttaat accttgccct tatttttctc tttgttcatc ttccttattg 3919921 ctttatataa tttcatctgt gcagttaata acgttccttc ttcacctttt ttatctgata 3919981 acagacatgt atttattgat aaaacattat acttctccga ttgatacaaa aaatgcaaat 3920041 cttcttccgg atatttaaca cccataaaat cttcataaaa atcgaaaaat ttcctttgac 3920101 cttccactaa tatatttgta gctttttgat ctagtttatc caacatttct gaggggttag 3920161 gagatttcat aatactatca atcaaaagtg tcctcgtcat gtctctagat atatcgtgat 3920221 ttcctggcac taagtgtacg ttattcttac ttaatcccat acttttaata attccattaa 3920281 gatattcttt aacatcttcg ttatacacat cacctttgtg tgctatatct ccagttaata 3920341 ataaaaaatc aaaatctgac tctcttctta aaacttctat aaaatctaat aatttatctc 3920401 tcattacaat agtgtcataa ttttgaaact gaaaatgcaa atcagaaatt tgtaaaaaac 3920461 gtaccttcaa tacaaacatc ctctcataag tatatttatc ccctatatat ttctagaaaa 3920521 ctttttattc tatatcatct ttactcttta atatattaag actctttcca caccatcaaa 3920581 taaattataa cctaaacata actctttact cattttagta ttgtatttaa gtcaaacatt 3920641 gcattggttg ctgaaatatt atattcattg aattattcca ttaaatagct tttagttgaa 3920701 ctttagtctt tctgtaatgg tggagatgct cttacttatg ataaggctcc ccacgattaa 3920761 tccgaaaagc ccgataaatc tgctccacta aaataagccg catcaactga tgaggaaatg 3920821 tcatcttcga gaacgatagc ttctcgtccg ctcgcttcat caccgtgtca ctcaatccga 3920881 gtgatccgcc gatgacgaag gtgactttgc tttttccata agtagccagc ttatctattg 3920941 tatcggctag ttcttcggat gttttcattt ttccttcgat ggcgagggcg atgacgtggg 3921001 cgtcggggct gattttggat aggatgcggt cgccttcttt gtcttttatg attttcatgt 3921061 cctggtcgct taggttttcc ggcgcttttt cgtccgggag ttcgatgatg tcgatttttg 3921121 cgtaggccga aagtcgtttg gtgtattctt caatgccttg cttgaggtat ttttctttta 3921181 gttttccgat tgtcacaata ttgatattca caggtcatcc ccactttaaa aacaagttat 3921241 tcatatatgt tgtccacaat tgtggatatc ttttctgtat tttgtgtaag atcattcgtt 3921301 ccccactata tatactgcgg ggtctccaca taattcacag gctgtggata aactgttagt 3921361 atgttcgatt tttctgattt cgggcggcag ctcgtggtcg tctatgtaca tatccagcac 3921421 cgtttcgatg tgttcttcac aagaataata cgcttgtttc atgttcaaat cctccgatgt 3921481 tttcttccat ttttacaaat gttctcttct caatataacc tatttattca catgttagta 3921541 gtgcttcggg ctgagtttta tccacaattc gacaaacaag ctgttgatga ctctatttcg 3921601 ctcgtgtgtt agtttggatg taaccgatgt gtggggaggt ctgcatttgc gctttagatg 3921661 ggtttggctt tttgtgatta tgttgctgct tgctgagtgt cagccatctt attgggtgtt 3921721 ggagaaggat cgaatcggtg aaggcagtcc agacttagaa atatacgcta attatctcca 3921781 aatgcatgat gacgtgaaag gatatcaagt cttcaccata tcagaaggca aaaaaatggt 3921841 cgtcgtgtct ctcggaagca gcgagaaaga taagaagctt gaagtgtcgg acgtcaaatt 3921901 ctcatctaaa gaaacgattg taactgtgga gcgaaaacct gctcctacgg caaatgagaa 3921961 aaaccctttt attttgattg gactggacaa aattgaaggg gatttaattg ttcaagacga 3922021 aacaggagat cgctttgaag aaacggatta ccagcaataa agccggcgtt ctgagaacgt 3922081 ccggcttttt cttttacttc aatgtcccat gcgggtcgat gacgaatttt ttggctgcgc 3922141 ctttgtcgaa gtcgctgtag ccttttggcg cgtcgtccag agaaataacg gtggcattga 3922201 cggcttttgc gatctgcgct ctgccgctca ggatcgcttt catcaaattg cggttgtatg 3922261 tcatggcggg cgtttgtccg gtgacgaagg tgtgggcttt ggcccagccg agtccgaagc 3922321 ggatttttaa tgagcctgtt ttggcgtccg catcctttgc accgggatct tcggtcacgt 3922381 ataagcctgg aatgccaagg ctgcctccga cctgggtgac gtccatgatt gagttcagca 3922441 cggcggctgg cgcttctcct tgattgccgt gcccagatgc ttcaaagccg acacagtcca 3922501 ctgcagcatc aacggttggt tcacctagta tttgttcaat ttgctcgccg aggcggtcgt 3922561 gtttttgcac gttgaccgtt tcacagccga agcttctggc ctgtgccagc ctgtcttcgt 3922621 tcagatcgcc gacaatcacg gtagaggcgc ctaggagctg agcggagtgt gcagctgcca 3922681 agccgacagg acccgctcca gcgatataaa cggttgaacc tgtttgcacg cccgctgtat 3922741 aagctccatg gaagccggtc ggaaaaatgt cggacagcat ggtcaaatcg agaatctttt 3922801 ctagcgcctg ttctttatca gggaatacca aaagctgaaa atcagcgtat ggcaccatga 3922861 catattcaga ctggccgccg acccagccgc ccatatcgac gtagccgtaa gccgatcccg 3922921 gccggtccgg attgacattc aggcacacat gcgttttctg cgttttgcac atcacacagc 3922981 gtccgcaggc aatattgaaa ggaacggata cgatatctcc ttttttgata aattcaacat 3923041 cacgccccgt ttcaatgact tctcccgtaa tttcatgccc gagcaccaag ccttctggcg 3923101 ccgttgtgcg gcctctgacc atatgctggt cgcttccgca aatgttggtt gtaatgactt 3923161 tgagaataac cccatgctca cattttcgat tcacattcgc cttcgggacg ccgggcccgt 3923221 ccctcaagat taactccgga taaccgatat cctccaccgc tacagtccct ttgcctttgt 3923281 acacaaccgc tttgtttcct gtcaacgcca ttcctcccat tcatgtgttt ggactctccg 3923341 tccttgaaca tgacttcggt tcggcatgac tctttccctt tttcacgact gttttttctg 3923401 tattcttaca acaacaaata tgccaagaaa gcatccaata atggttccgc cgatgtctaa 3923461 gaagtcgact ttacatccat ttaacaagaa cacagtaatg gccgaaacca ggcagatcat 3923521 aactgccaga agaataaccc gatttgtctg catgtaattc ctcctttgga ttcgtttcta 3923581 aaccataccc aaaatcctct gcaaacttcg gttcaacaaa aaaagagact tcacaccagt 3923641 ctcttcataa acagagatca ctcaaaaaat ttcctgagaa ataatgtggc aacactcgtt 3923701 actaacgcaa ttgccgtata cataacaacc caaaatatga atgagctatt ccccgaagct 3923761 aacgtaacta acaatatcaa gctcgtgata agaacgatga gcggtgccac ccaaaatctt 3923821 ttaaataaaa aatgacccgc tataccaaat acacctgcga cgatcggaaa accaaaaacg 3923881 ataaataaaa cggcgatggc tcccatacta ccctccttgc cttaaaacct cttcatcacc 3923941 tcaacatcat acagcttcaa atgactcttc ggcgtcacga catcctttac cttcccaatc 3924001 tctttttctt tcattttctt tccggttttc aggctgtact gttcaatgta ggcaggcttg 3924061 tgatacgtgt atgtgaagaa atagaggctg ctgccttttt gggtgatttc tttgaattcg 3924121 gctttcattt tgtccgggga aagggtgaag acgatgcttg tttttcctgt cttggcatcg 3924181 attttgtgta cctttccgaa gccgtcaatg aaatacaggt tcccgtcata agggaaaaag 3924241 ctgtttttaa agctgaaggg catggagctg tatatcgttt gttcgtcgtt tttgtattcg 3924301 gcgatatcgt gcagctctac ttcgccgctt tttttgttga tcttgaccat ttgatagaga 3924361 tcgtgggctt tttggccgcg aaccataaca tacacagctt ggtcgtccac ggcaagttgg 3924421 gattcgactg aggctccttc ccggtactgc cattccgtta tgctgagata ggtaagcttc 3924481 ttctgatctg cttgaatctg aaggagctga tagccttttc cgtcatctgt cgggacgagt 3924541 gcgtaaatgg cgccatcatg gaaaccggag gctcggatgt agtaggggat gacgtctttt 3924601 ttccactctc cgtccatttg gcggtacagc tctgagcggt atccgtctcc ctttttgtcg 3924661 tagccggagt tgtataaggt gtaaaagccg tccgtgtttt gcagaaagcc cgcgctgtcg 3924721 cctgtgtgct gataggttct tttatgggag cgcaggccgt ttttgatcgt ataaatcgtg 3924781 tttttgtcct ccagcatcac gctgtcaccg tgaacctttg ctgagcccag ctcaaggccc 3924841 ttcatctgaa aggaagacag cgtcccgtca tggctgataa acagggcgta gcttttcccg 3924901 ccgccaaatg catcttgatc cgcagaggat gagaaataca gcaggacttc tttgtcatcc 3924961 aggaaatcgg gatttctgag atcctgctga ctcacggttt tatggctttt gagaggagaa 3925021 atgaagacaa atagtgcgat tcctgcgaga atcagcatgg cgatggtaat catccacttt 3925081 ttcatagcct tctccttagt aaatggtcat aatggttgtc gtataagaag aactagtgat 3925141 gtcgcgcgga tacacgccta agcctccgtt gctgtctata tcaatccctg ctttcagcaa 3925201 aaaggcagac cataggagct ttgaacagtt tttggcgccg tcatggccgg tatttctgtt 3925261 attgacgaag ttaaatgagt atgggtcgcc gacttttgat accgcccagt cggcagcagc 3925321 tgttttttga gatgaggata cgctgacggt ttgcacaatg gagttgtctt ccacgtctct 3925381 ggcattatac gcgatctgcc tgacgccgtc gctcgggaca gattcaacaa ttttgtcagc 3925441 ggcggagtac atgccgacat ggccgtgatt gtagtaggct gtgtaggagt tcgtgtaata 3925501 gatattgcct ttcgcgcttg tcgggagttt tttcgtgccg gacgagccgc ccatgataga 3925561 catgccgctt tccttggcga gccggtcccc ctctgcttta tcagccgtga tctccttata 3925621 gaactgtttt aggataacgt cctgctttac gtgctgctgt ttggcaatct ggctggcaga 3925681 tttcatgatt tcttccggtg tcgtgcctgg ctgcagtgcg gcgatttctt cagcataatt 3925741 tgtggtcttt acggctttgg cgggagtaac aaacaggccg ccgcacattg tgagcgctac 3925801 caaaaacatc gacactcgtt tcttcaactt cattacatct cctcttttct tgtgagtgta 3925861 ggaaaggtaa tttcctcacc cacattatat taggaaaata aggaaagtaa ctaggttatt 3925921 tacagaattt ttagaaatcg tttacagaaa aaggccttta tcaggccctt ttcgttaaag 3925981 cttcttgctc atcactacgt ctgtttcttg aaatccggtt tgctcatata gctttcgagc 3926041 cgtctgatta tgggcaaaga catgaaggga cagcttgcgg attcccatac tgcgtgccgc 3926101 ttgatctaat gccgccaatg cttgctttgc gtagcccttt ccccgatacg gttcatataa 3926161 cccgaaatca taaataaacg cttcctgctg cggatgctcc ggttcagcat gtatccagag 3926221 ccagccaacg atatcctttt cattcagctt gaggctccac aaatggtgat ggggtgtttc 3926281 gagccctctc ggaagcagat cagtaaacac ctgcttagac aaaagctggg catcttcagg 3926341 cagccatgtt cccgctttta ccttttcttc cgcgtaatgc tttgttgtgt acgtgagata 3926401 agaccgaaat tcttctgtct gcataggggt tagcataatt gtcatatcat ctctccttca 3926461 tatattgact agaggatttt acataaaata gaaagaggtg ttactatcag aataagcaac 3926521 tgagattgat aagtcactag agaaaggagt ttcacatgaa taagatcgca cccgcagaaa 3926581 tcgctagcat gctcaacgat tggtaccttg ccatcaagaa acatgaagtt gaagaatcct 3926641 cccgtttatt tgaagaagtg aagcctttat tggatgacat ggaagaggat caggaggtgc 3926701 ttgcctactt ctccttattg gaactgcgcc acaaggtttt gcttcacgag gcgagaggac 3926761 agggctttca gcatgaggag ccttctcata tgaatgctac gtctgacatg ctgaaatatt 3926821 acttttttct gtttgaaggc atgtatgagg cctataaaaa taattatgac attgccattg 3926881 ggctgtataa agatgcagag cagtatctcg acaacattcc cgatccgatt gaaaaagccg 3926941 aatttcacct gaaggtcggt aagctctatt ataagctggg acaaaatatt gtgtccctca 3927001 atcatacacg gcaagcagtc aaaacattca gagaagagac agattataaa aagaagctgg 3927061 cttcagccct gattaccatg tcaggcaatt ttacagagat gagccagttt gaagaagctg 3927121 aggcttattt ggacgaagca attcggatca cgagtgaatt agaggatcat ttttttgaag 3927181 cccagctttt gcataacttc ggccttctac atgcgcaaag cggcaaatca gaagaagcgg 3927241 tttcgaaatt agaggaggct ctacagaacg atgagtatgc ccgctccgcc tattattatc 3927301 attctgccta cttgctgata cgagagctgt ttaagatcaa aaagaaagaa caggccttat 3927361 cttattacca agacgtgaag gaaaaattga ctgctgagcc gaatagaata tgtgaggcaa 3927421 aaatagacat tttatatgcc atttatgcag aagggggtca tgcggaaacg tttcacttat 3927481 gcaaacaaca tatggatgac ttgttgtccg agaaagagta tgacagtgta agagaacttt 3927541 ccattttggc tggcgaacgg tatagggaac ttgagcttta caaagaagct gcccactttt 3927601 tttatgaagc attacagatt gaagaactga ttaaacgaac ggaggttata taaatgaaaa 3927661 gatttctgat tggcgcaggc gtcgcagcgg tgattttatc aggttggttt attgcggacc 3927721 atcaaaccca ctcacaggaa atgaaagtcg ctgagaaaat gattggataa atgaaaaacc 3927781 cccgcgggat gcgggggttc aatttaacga aagaatccta aaacggtttg tagttttagg 3927841 attctttcat cttttcagcg tgattgaaaa cccttgaagt ctaggaagaa cgagcattgg 3927901 agcgcagcga atgtttggaa ttcgtgagca ccgaagcgca ggcctgacaa cgaatgcgag 3927961 ggtttgtcga cacgctgaaa cccccgcggg tgcgggggtt ttcttattac agcagcttct 3928021 tccctaacag ggattctacg agctctactg ctgttttgcc cgttttgttt ttgtgatcaa 3928081 ggatcgggtt aacctcaacg aattcggctg aggtaatgat gcctgcgtca tacagcattt 3928141 ccatagccaa atggctctcc cggtagctga tgccgccgac gacaggggtt ccgacacccg 3928201 gtgcgtcgtt cggatcaagt ccgtccagat caaggctcag atggacgcca tcacatgctg 3928261 ataaataatc aagggtttct tcaatgacct ttgtcatgcc aagacgatcg atttcgtgca 3928321 ttgtgtacac cttcatgccg ctttccttaa tgtacttgcg ctccccttca tcaagtgacc 3928381 gggcgccaat gatgacgacg ttttccggtt tgattttagg cgcgtagcct tcaaggttaa 3928441 ccagtgactc gtggccaatg cctaggctga ccgcgagcgg catgccgtga atattgcccg 3928501 atggtgaagt ttcaagtgta ttcaaatcgc cgtgcgcgtc ataccagatg acgccgagat 3928561 tatcgtaatg cttcgctgtg cctgcaagcg tgccgatcgc aatactgtgg tcaccgccca 3928621 ggacaagcgg gaattttttc tcttcaatga ctttgttgac cttttgcgcg agtttttcat 3928681 ttcccgccaa aacggaattc aggtttttca gttcctcgtc atttttgatt ttttcgcgat 3928741 tgatcggaat gtcaccgaga tcttcaaccg tataccccat gtctgacagc ctctcgatca 3928801 gatgagcgta ccggatggca ctcgggccca tatccactcc gcgtcgtgct tgtcctaaat 3928861 ccattggcat tccaataacc gaaatcgttt tatccatctg tgattccacc tcaacattta 3928921 agataatgtc ctatgcgggt tataacaaag atgacttgcg gacaacgttt ttaaagctct 3928981 agctgacgat ttgcctgctg gcgtttttta atgacgacat gataaatgat gtagcaaatg 3929041 atcataaacg gtacgccgca atacagcgcg atacgctgct ccggatcaaa tgcaagactg 3929101 atgagcacga ccgtatttaa cgttaggccg atcagcggaa gcaccgggta cagcggtgtt 3929161 ttaaatttca aatcttctat cttcccgccc tcacggatat atttgcgtct gaacatgatt 3929221 tgggaaagcg agatcgtaat ccagccgacc tgcgcgctca tgcccgccaa agataacagt 3929281 accatatata cggtttcagc ctgcgcaaac tttgtcagaa gtgataggca ggccacagcc 3929341 atcgttacga ttaacgagta catcggtaca ccgcgctgat ttgttttgcc aagcgctttg 3929401 aaggcttgtc cttcattcgc catcgcgtac agaatacgtg ttgatgcgta taaacctgag 3929461 ttcgcaacag ataacagtgc gattaaaata acaaagttca tgatatcagc tgcatatggg 3929521 attccgattt gctcaaatac ggcaacaaat ggactttcca cgacacccgc ctgtttccac 3929581 ggaatcatgc cggcaatgac aatgattgaa agcacaaaga acacaagcgt tctccatact 3929641 gtctgtttga tggaccgcgg aatcgttttt tcagggtctt cactttctcc ggctgcaacc 3929701 ccgatcagct cagtcccctg aaacgcaaag ttcacagtaa tcatcgtaat cagcattgcc 3929761 tttatgccgt tcggaaataa cccgtcttca taaaaatgtg tcaaaaacgg cgcctgctct 3929821 ccgcccttca gatcaatcag gccaaacatg gcagctccgc cgagaataat aaataaaagg 3929881 ataatcaaaa ttttaatgcc tgagaaccag aattcagatt ccgcaaaggc ttttgtggtg 3929941 atcgcattta aaataaacat cagtgccgca aagaccagac accagatcca cacgtctata 3930001 tgcggaaacc agcgttgcat cagctgcccc gctgataaaa attcaatggc gcatgtaacc 3930061 gcccagccga gccagtacag ccagccgaac gcaaacccga aggccgggct gataaatttc 3930121 gtggcatagg tctggaagga ccccgacaca ggaaaggcga ctgccagctc tcctaagcag 3930181 agcatggtca aaaacatgat aaagccgccc actaaatagg acagaaccgc gccgagcggt 3930241 cccgcttggt taatggtaaa cccggttcca aggaagaaac cggttccgat cactccgccc 3930301 aatgaaatca tgaacaaatg gcgtgatttc attgtccgct ggagctgatt tccgttatct 3930361 tggtttgtat tcacattctg caccccttca gcaacttgta ttggatctaa gctggaacat 3930421 ctgcatggtg ctatcccagt ttgctgtcca aagagtctct atctatttaa tataaaattc 3930481 acttcttctc ataaagatac attatactaa aatactgtag ctgagcaaat agggagtgct 3930541 gatttttctg ttgtaaattt atacaaacga agtgaatatc ccgccatggt gcggatttat 3930601 gcgtttcgca gcacgtgctt aattttctct atcgcccaat ccaagtcctc tttggaaatg 3930661 attaatggcg gtgcaaaacg aatgactgta tcatgcgttt ccttgcataa aagtccctct 3930721 tccttcaaac gctcacaata cggacgtgcc gcttcagtca attccacacc gataaacagc 3930781 cctctgccgc ggacttcttt aatgacaggg ctgtcaatac tctcaagctc gcttttaaag 3930841 tattcaccaa gttcaagaga acgatccgcc agcttttcat cctccagcac ttctaatgaa 3930901 gcgatagaca ctgcacatgc aagcgggttt ccaccaaatg ttgagccgtg tgagccaggg 3930961 ttaaacacgc ctaggatctc gcggtccgcc gcaatgcaag agatcgggaa cacaccgccg 3931021 ccaagcgctt tgcccaagat atacatatcc ggaacaatgc cgtcccagtc acaggcaaac 3931081 gtcttgcctg tacgtccgag acccgtctga atttcatccg caataaacaa gacattctct 3931141 tccttacaaa tcgccgccgc ttcctgtaaa aatccttcag gcggaatcac aatgcccgct 3931201 tcgccttgaa tcggttcaaa caagaatgcc gctgtattcg gcgtaatggc ctgtcgaagc 3931261 gcttccacat cgccgtaagg aatgagtttg attcctggaa gcatcgggcc gaatcctcgt 3931321 ttatattcct cttcagaaga aagagatacc gccagcatcg tgcggccgtg gaagttcccg 3931381 acacatgcga taatttccgc ttgattgtca gctacgccct tcacttcata cgcccagcgt 3931441 ctcgccgctt tcaccgcgga ttcaaccgct tcggctcctg tattcatcgg cagaatcatc 3931501 tctttgcctg tcagtttagc tgttttttcg taaaacggcc caagctgatc gttatgaaac 3931561 gcgcgtgacg tgagggtgat tttatcagcc tgatccttta atgcctgaat gattttcggg 3931621 tgtctgtgcc cctggtttac cgcagagtaa gcactcagca tatccatata ttcattgcct 3931681 tccgggtcct ttacccaagc acccagcgct tcagaaataa caatcgggag cgggtgataa 3931741 ttgttggctc cgtaatgaga cgtctgatca ataatttctt tggatttaga taaagctgtc 3931801 atatttgaat tcccccttgt tttctgtttc aacatgttat cctgctttcc ctttatataa 3931861 atgcaagttc tgtgccaaat caagaattcg tgtgttttct acaattttcg aggacaaggt 3931921 gcaaaaacat tctgatattt cgagcgaaaa tttcagcaag tgcaaaattc ttttgcatat 3931981 cctctccgtt tttttataaa atagaagcaa tattaagaaa ataattgagg gaggttcata 3932041 cagtggtcaa agacagcgaa ttcctcacat tggtttttca gagtatttta gatgaaatcg 3932101 atgttggcct gcacgtggta gacgagcatg gaaacacaat cgtttataac aataaaatga 3932161 tgcagattga agatatggag aagcatgacg tcttgaataa aaacctgatg gatgtgttta 3932221 tgttttcaaa gcagcaggac agcacactgg tacaggctct tcaggaaggc aagacgatta 3932281 aaaacgtcaa acagagctat ttcaataata aaggccagga aattacgacg atcaatcata 3932341 catatcccat cgtccaagac ggcaaaatca ggggcgccgt tgaaattgcc aaggatgtga 3932401 caaagctgga acggctgatc agggagaata tgaacaaaaa aggcagcaca acctatacgt 3932461 ttgacagtat tctcggcacc agtccggcca ttcaagacgt catcgaaaac gccaagcggg 3932521 caacccgtac gtcatcatct gtccttctag caggcgaaac cggcacggga aaagaactgt 3932581 tcgcgcaaag tatccataat ggaagcgatc gttctggcgg cccgtttatt tcgcaaaact 3932641 gcgcggcact gccagacagc cttgtggaaa gcattttgtt tgggacgaaa aaaggcgcgt 3932701 ttaccggcgc tgtcgaccag cccggcctgt ttgaacaagc ccacggcggc acactgctgt 3932761 tagatgaaat caactcgctg aatctcagcc ttcaggcgaa gctgctgcgc gcccttcaag 3932821 aacggaaaat caggcgcatc ggttcaacaa aggatacacc gattgacgta cgtattattg 3932881 ccacgatgaa tgaagaccca attgatgcaa ttgcaggcga acgaatgcgg aaggacttgt 3932941 attacaggct gagtgtcgtc acactgatca tcccgccgct tcgggaacga aaagaagaca 3933001 ttttgcttct cgcgtcggag ttcatccaga aaaacaacca tctgttccaa atgaatgttg 3933061 aacacatcag cgatgacgtg aagcaatttt tcctttctta tgactggccg ggaaatattc 3933121 gcgagcttga gcatatgatc gaaggcgcaa tgaatttcat gacggacgag caaacgatta 3933181 cggcttccca tctgccctat caataccgca tgaaaatcaa gccggctgac atcccagagc 3933241 cggaaacacc aagacaccag ccagccgcgg acttaaaaga aaaaatggaa agcttcgaaa 3933301 aatatgtgat agagaacgtg ttaagaaaac acggccataa catctcgaaa gctgctcagg 3933361 agcttggcat cagcagacaa agcctccaat atcggctgaa gaaattttct cactcgtcta 3933421 acgaataatc cggagcagga agcctgatca gaaaaacagt gcctctgccg atttcacttt 3933481 tcacttcaat cgtcccattg tgattgtcga taatcgattt cgttatggca aggcctaatc 3933541 ccgaacctcc atatttccgg gagcgggatg ggtctgcctt gtaaaaccgg tcaaacacta 3933601 aaaaacgtca cttcttatgc attgaagaaa gaaaatggca cctatgtgta tcacagccag 3933661 caaccacacg gtacaaacca ttaaagtcca tgcaaataac ggaagtattt gcagctaact 3933721 gccatttgct gtttcacgtg taacatccat cttgtatttt tcttcatatt cgatatatcc 3933781 tttttcaact gaacgggcgt gacccctgtt cagttttttt tgcatatcaa aacagcctgg 3933841 caacgatgcc agactgcttt tattaactgc ctaattggtc tgcggaggac agcttgatat 3933901 caacagattt ttcttttccg ccgcgataaa acttcacctt cacccggtca ccgacttttt 3933961 tctgataaag ccgttttcgc aggtcaacaa tatcatttac tttgtatccg tcaaattccg 3934021 tgatgacatc cagttccttc agccccgctt ttccggcagg tgaaaaggcg tctacaccca 3934081 tcacaaccgc tccattggtg acgttcttag gaagctttaa tgtttcatcc caatgatagc 3934141 ttgcgatgtc acttagcgat ttcatctcaa tgccaaggaa cgggcgtttg acctttccgt 3934201 atctctctaa atcctctatc acagggatca cgagcttaga cggaatggac aggccaatcc 3934261 cttcaaccgc tgactcggca attttcattg aattgatgcc aatgaccttc ccatccatat 3934321 ttaacaaagc gccgccgctg ttcccagggt taatggccgc atctgtttgc aggacttcag 3934381 cgttccagtc aggctgtcca tcaccgtttg aatctactgg gatcgccctc tccgtacccg 3934441 agatgacgcc ttgtgtgaca gagcctgcaa actcaaggcc taacgggttc ccgatcgcaa 3934501 taaccggctc cccagacttc actttatctg aatttccgaa atcagcgact gctttaatct 3934561 tatcgctttt cacccgtaaa acggcaaggt ccatcagctg gtcgctgccg acaagatcag 3934621 ctgatacacg tgagccgtct ttcaagctga tttcaatttg ggaagcgcct tcgatgacat 3934681 gatggttggt cacgacataa gcggaatggt catttttctt atagatgacg ccagagccgc 3934741 tcccagcctc gccgctctct ccccaaatat ctgatttttg gatgttcaca acaccgacaa 3934801 cggcgggcga catattgctg acaatcttgg tgacggcatt gttgacactg acattcaccg 3934861 tcctgattga ttcccggcca ttgttgtttt gctgctgatc taaggcgcct gtatccagcc 3934921 cttcatttga aaggtacggc atgataaacg ccattaatac ggcaccgaca atcacgccaa 3934981 tcagactcga aagaaaatat ccttttttgc ttctctttgg ctgttcagga gtagtatgtt 3935041 cttcctcacg ttcgtaatcc accatattcc atcctttcca agaacgttaa tatggttata 3935101 ttgtgggtta gaaactccta gaatagtcat gatttacata gaaaaattat acagcgcaaa 3935161 gcggagtggc cttcttcgga tcggtgtcgt ataagtcaaa tgtctcaccc gtcacaaatc 3935221 ctttagaagc caatgtctgc tgcacagaca ttcttgccag ctccttcatg ttgttgtcct 3935281 ggctcaaatg cgccaggtaa atacgagacg tctcatcgcc aatgacatcc gtcatcgcca 3935341 aggcagcatc ttcatttgac acgtgcccga cgtcacttaa aatccgccgc ttaatgctcc 3935401 atgggtatct tcccatttgc agcataccga catcgtgatt gctttcaaac acaaatacat 3935461 tcgctgaacg gataatgcct ttcatccggt cgctgacata tcccgtatct gtcattaacg 3935521 cgagctttcg gccgctataa tggaatacat aaaacatcgg ttccgccgca tcgtgggaaa 3935581 cgccaaacga ttcaacatca agtccgccga acgacttcac cgtctccatt ggaaatacaa 3935641 acttttgatc ggtgtcaatt ttgccgattt gattctccat cgctttccaa gtcttctcat 3935701 tcgcatagat cggaagcttg tactttctgg cgacgacacc aaggccctta atatggtcac 3935761 tatgctcatg cgtcacaaaa atgccgtcta catcatccag cttacgcccg atctgcgcca 3935821 tcagcccatc catggctttt ccgctcaaac cggcgtccac taaaaatgcg tgatcctctg 3935881 tttcgaggta aaacgcattt cccgtactcc cgctcgcaag tacgctaaat tgcaagctca 3935941 tgtttgtctc actccattat tttcattgat ctgtatctaa aatcgtactc tccaaagcat 3936001 tcacagtaaa atactcttgt actgtctttt tctcaccgtt cacttttttc tcgtactcga 3936061 ccgtaattct ccataccggc gccagcacct gcgtacttgt cagcggatat tgtgctacat 3936121 agccgaattt acagctcttc acagtgctgt attcttttaa ttgattttga tagtacaata 3936181 gctcaaccgc atccatttca gtaattaagc tttctttctg gatttgcttg aaggtctcaa 3936241 gcgtagtctg gtcgtatgac acaacctcgt ttttaccgtt taagtgcagc accacttgcc 3936301 cgatcatatt agagggattg tcggtctttt ggtaaatata atgaccttcg tacgtttgga 3936361 agaaaataat ttctttcttc gatttatcaa ccttccaaag cttatatttt tcgccatctt 3936421 gaattttcga agaaacaagt gcctgagcat cgtcctcgat atccttcttt gatagtgcga 3936481 ttggatttgc aaacttcatt ttcaggctcg ttactttatg atcatcacta ggcatgtcca 3936541 tcaaaggctt ttgatccttc agcgcctcaa tttcctcctt ggagaaagac ttttgatttg 3936601 ccgtgatccg atagccttct gttgcttcct tattcaagcc ttcatacgtg atatgatcgg 3936661 ccttcatgtc atgctcgaca tcatttttaa tgacttcata ttctttgccg gtagcctgcc 3936721 atttttgaaa aaactgatag cctaagaaaa tatctaaaat gaggaaggca acgatgaaga 3936781 ttgattttgt cttattccac tccactgtta gccccctcct tcctcaataa atcctttgta 3936841 atcggcacaa tttttccatt tactttcatc gcccaaaccg gttccagttc aacgagagga 3936901 tcatcgttgg ttgatgttga taccaattga taagcaagga agatctgatc aattttgtcc 3936961 gtatcataag cggtttgttt cgaaagcagc atcttcactt cgctgccgcc catgagctct 3937021 gtttcacttg ttttaatcgg attcgttccg agactgtaat tcggccgctt atagctgaga 3937081 atatcatcat tcgcccattg caccgtaatc gccgatgtcg ccccgaaagg tttggcggtg 3937141 ctgttaatga ccgggatctg atccataaaa atatagaagc tcaactgctg gctgtcattg 3937201 atattgaaaa attgatagtg atccgtccag cttccggtat cctcaaggta tttttggctc 3937261 tttttgatta attcacctgt ttgataggat gtgctctgca ccaaattgcg ctgctgaaat 3937321 tgcacctgtc tctggcttag attcacatct aaccggctga tcccatctgt cagcacattt 3937381 ctgttgttgt aattcgaatc ttctcttaca atgctcggat cactaaacaa agcctgctta 3937441 aaggtatttg ttttaatcga ttctgtgaca aattcttttt tgtccatcgt aagcggtttg 3937501 ttcggcagca agaactcttt ctttgagcca atggagaaca aactgaacgc cggcatattt 3937561 gattgcctgt ttttcaagtc gttcataatg ttccggtagt ttgctgattc aaccgtcact 3937621 tcaagaatga gctgcttgct gtatgacacc aaatagattt tcttgttcgc ttttgtttca 3937681 ttgaacggga tcagaatatg gtcaaacgaa ctgtattcaa acgactgatt agaccattta 3937741 aacagcgttt ggaaaatatc aatcgggatc gtatcgctga attgcaagtc aagcttggct 3937801 tcagaaccgc ctattccata aaaccagctt ttgaatccag ccttgtcata ctgatccgaa 3937861 atatctttaa ttcctttcac atcccaatgc ggcaagtcag accaaatttc ttcatagagg 3937921 gcattgtcat ccactttgta atgagcgccg tcatcatgga taaacatgtc ccttggcctt 3937981 accgtttcag acagcttttg ggtggttttt tcgattttat gtttcacacg aacagtagac 3938041 tctgttgagg atgagccttc agaaaagttt ggctggaacg tccatatccc ccatgtaaaa 3938101 acaagactga tgacgacgag taccgtaagt aatatcgttt ttatattttc acgcttcatc 3938161 ccaatcatcc tcttgttcct ctttatatgg aagagtaaat gtaatcgtcg tgccttttcc 3938221 ttctatgctg tccgcccaaa tatctccacc gtgcgcctgt accatttcct tggcaatcgc 3938281 caatcccaga ccggtgccgc caagctttct cgttctcgct ttatccaccc tgtagaagcg 3938341 gtcaaagact ttttcgacat cttttttcgg aatgccgatc ccttcatcct tcacgctgat 3938401 atagagaagt tcttcctctt cattgacatc aatcgagaac gtgacatgtc cgccttccgg 3938461 tgaatatttt aaagcgttag aaataatatt atcgagcacc tgcgttattt tatcctggtc 3938521 aatctcgaca tacagatctc tgtccggcag attgcggata aactccacat gctgctcttt 3938581 tgtcatttca aaacggtcaa taataagtga cataaaccgg acaatctgaa tccattcccg 3938641 gttaaattga taatctttac tgtcaaattt cgacagctga agcagatcat tgacaagccg 3938701 gatcatacgc tctgtttcat tttgcgtcac cattaagaag cgcggagcaa tgtctttatt 3938761 ttcccacgcg ccttcagcta acgcttctaa atagctgcgc attgtcgtaa gcggcgtccg 3938821 cagctcatgt gatacattcg caacgaattc tctgcgttcc tgatccattt tctcttgttc 3938881 ggttacatcg taaatgacag cgattaaacc atcaattttg ccgtgttccc tttgaatcac 3938941 agagaaattc acgcgaagca ccgttaattc atcatcgcgc tcaatttcaa gcagcataga 3939001 atcctgctgt tccactaaat cttcaaaagt ataattctct tgaagcccca gcaaactcgt 3939061 aatcggcatt tctaaggctg tttcacgtga aacgttcaac agttccagcg ccgggctgtt 3939121 taagagaata atcgctccgt ttcggtttgt ggcgataacg ccgtctgtca tataagcaat 3939181 gacagaggct agctttctgc gttctccttc agtcatcgcc tgggcatctt caagctctct 3939241 cgttaagtgg ttaaacgttg tggccagctg cccaatttca tcatgtccat actttttaac 3939301 cttcctcgag aaattccctt tcgcaagctc catcgcctgc tttcgcatat ctgaaagcgg 3939361 gtgggtaatg gttcttgcca gaaaaatacc gagaagagcc gtcaaaacaa gtgccaaacc 3939421 tgtgccggac gccagtatcg tgttgatcgt cttcatttga ttaaagacat cttccatact 3939481 cgcgacaacg tagatcgcgc ccacaacctc ttggttttca gtcatgacgg gcttcgcgga 3939541 aataagaact ctgattttgc ttttcgggtc ataatatttt cttaaatacg actgtttggt 3939601 agaaaagatt cttttgaaaa tcagatcggt cgtttgtttc ccagccactt cctcaccgta 3939661 cggctttgaa gaaccgacca cttcatagct tttatctaca aagctaattt cccgaacctc 3939721 atcacttttc gtgaagtcat tcaaaatacg gctgacgtca tcctttatga cggtactgtc 3939781 gttatcgctc ttatattctt gttcgatata ataagaaagg ttgtcgattc gctgattcag 3939841 cgattgttca taagagctga tcagcgactt ctctacctga ttgacaaaat acacaccaat 3939901 gatttgcatg gcaatgataa tcaaaagcac ataaatcaag gtaatcttaa attggatcga 3939961 ccgaaaaaaa ccaaccttat tcatatgggc attagtcctg ttctgggttt ctcaagtaat 3940021 aacctacacc acggcgtgtg acgatccaat ttggatggct cgggttgtcc tcgatttttt 3940081 cacgaagccg gcggactgtt acgtcaaccg ttctgacatc gccgaagtaa tcatagcccc 3940141 aaacggtttg aagcaaatgt tcacgggtca tcacttgtcc gatatgtttt gctaaataat 3940201 gaagcaattc gaactcacga tgagtcaatt cgattgtttc gtctcgtttt gatacaacgt 3940261 acgcgtcagg gaagatgacg agagagccga tatgaatctc gttagaggaa ggctcttcct 3940321 ccgcaggcgc tgttgtcagc tggcggcgca ggttcgcttt tacacgcgcc aagagctcgc 3940381 gtgtgctgaa tggttttgtg acatagtcat cagcaccgat ttcaagcccg ataaccttgt 3940441 caatttctga atccttagcc gtcagcataa tgattggcat atcgtatttc tttctgactt 3940501 cgcggcatac ttcaacgccg tctttatttg ggagcataat atctaaaaga attaaatcag 3940561 gctgaagctc ttctaccatt tcaacggctt cgtttccgtc gtgggcacag tgcacttcat 3940621 agccttcttt tcttaagtta aattccaata tatctgcaat cggtttttca tcatctacta 3940681 caaggatctt tttatccatc attttgattt tcctcctgcc gaatgacttc atttcatcta 3940741 tataacattc gtttcatcac ttatggccca tgtaaagaat gggtccttgt ctattataac 3940801 ggtttaaggt caaaagataa aaaaaataaa ggtttagaaa aaaaacacat gtttcacctt 3940861 tatcgccagt tgtttatcta ttgtcatgct ggtcaacttt ttttaaaaaa gataacttta 3940921 ttgaaacctc ccctcaccgg agtgcgtctt tatcaatgac gtcttcttct ttgaaccggc 3940981 cgcagggccg gttctccctt tttcttctat tataacactc ctcatgtttg cctttttcct 3941041 aaaagaaaaa acgcacctac gattgcagat gcgtttggta agtggctcgg gacggaatcg 3941101 aaccgccgac acacggattt tcagtccgtt gctctaccaa ctgagctacc gagccaaatg 3941161 ttttattttt ctctactaag taaagtaaaa tggcggtccg gacgggactc gaacccgcga 3941221 cctcctgcgt gacaggcagg cattctaacc aactgaacta ccggacctta cagtaattgc 3941281 ccggagagct gtcgtgtcag ctctcacaga caaataagga atttagcaat aacgctaaag 3941341 taaatcaatg acccgtacgg gattcgaacc cgtgttaccg ccgtgaaagg gcggtgtctt 3941401 aaccgcttga ccaacgggcc ttcacgaaat ggtgagccat gaaggactcg aaccttcgac 3941461 cctctgatta aaagtcagat gctctaccaa ctgagctaat ggctcttaaa gatgtcggaa 3941521 tttctataga gcaaacgact taaatctagt tctcatcttg tactctattg aagcagtttc 3941581 cgtaacaacg agatttataa tatcacgaac aaatagaagt ggcaataact tttttggttt 3941641 tttttcatat ttttttctca gaccaactta tatgcggctt tcaaacaaaa acaagcccct 3941701 taaatagggg cttgcagaca tattctattt agttcgcacg gtacacactg cgaaggacat 3941761 ttgtttgtga gcggtctgga ccgacagaga aaatagaaag cggaatgcct gtcagctgag 3941821 acacacgctc aagataatgg cgcgcatttt ccggaagctc gctcaagctc ttcgcacctg 3941881 taatatcctc agtccagccc ggcatttctt catataccgg ctcacattca gcaagtgcct 3941941 taagacttgc tgggaattct tcaatgattt cgcctttgta gcggtacgcc acacagattt 3942001 tcaacgtttc aattcctgct aggacgtcaa ttgagttcag agaaagatct gtaattccgc 3942061 tcacacggcg ggcgtggcgg acaacaacgc tgtcaaacca gccgacacgg cgcgggcggc 3942121 ctgttgttgt tccatattcg cgtccgactt cacggatttg atcgccgatt tcatctttca 3942181 gctcagtcgg aaaaggaccg tcgccgacac gagtcgtata tgcttttgat acaccgacaa 3942241 cgtgcttgat tttggtcggg ccgacaccag aaccgatcgt gacaccgccg gcaaccgggt 3942301 tagatgacgt aacaaacggg tatgttcctt ggtcgatatc gagcataacc ccttgtgcgc 3942361 cttcaaataa tacacggcgc ccttcatcaa gagcatcgtt taagacaaca gatgtatcgc 3942421 aaacatactt tttaatctgc tgtccgtact cataatattc gtctaagata tcctcaagtt 3942481 taaacccttc tgtctcgtac attttctcga gaagacggtt tttttcttca agattgcgct 3942541 caagcttttc cgcaaacgcg tcacggtcta acagatccgc gatgcgaatt ccgatgcggg 3942601 ctgctttatc catgtaagca gggccgattc cttttttcgt tgtgccgatc ttgttagccc 3942661 ctttacgctc ttcttccact tcatccaatt tcaaatgata cggcagaatg acgtgagctc 3942721 tgttgctgat tctcaggtta tctgtactca cgttgcgctc atgaagatac gcaagctctg 3942781 tgactaatgc tttcggatct acaaccattc cgtttccgat tacacacgtt ttatccttat 3942841 agaaaattcc agacgggatt aagtgaagct tatatgtgat tccgtcaaac ttgattgtat 3942901 gccctgcgtt atttccgcct tgataacggg cgatcacttc tgcattttct gataggaaat 3942961 ctgtaatttt accttttcct tcatcgcccc attgcgtacc tactacaact actgaagaca 3943021 tgtccgtgca cctccgttaa cctttcaaaa cgattctatt caaacaaatc aagtttatca 3943081 gtgaagaaac agaaagtcaa ttgtaaatcc gaacattaat ttattgtaaa tctatattcg 3943141 ttcgcttcca ttcgttttat aagcgttttc tcactgcttt gtcataaaaa gcttgcgaaa 3943201 ctttcatcct ttagcataag aaagaatcac ttgcctgata tcccttttga attcataaaa 3943261 acgatccgcc agccgtccgg gtcctctatc gtcacgcccc cattgctcca gtacgggttc 3943321 tctgattcga cctcttgata gcccatgtgc tttagctttg aagtgatcgc tgccagttca 3943381 actgcattcg gcacataaaa aacaagaagg ctgtcgggat ggggaacggg ggcagtgctt 3943441 cccccttcat actgggtgaa ttccaaatga taatcggcat gaggaaggcc gaacatgaca 3943501 ccgtcatacc cgttatgctg tgaaaattct cctattcgtt tcaaacacag tccctcttcg 3943561 taaaaacgaa taatctcatc aagctggccc gtaggacgcg caattcggat ttgtgctgct 3943621 tgaaaagacg aaaaacgttt tcccatattg ttaccatctc ctttttgcac cattttatta 3943681 aaacgctttc aatttttcat ccgctgagcg aacgtcattt cttccatctt tcgaatgaaa 3943741 aaaaccccaa gagcagctct tggggcttat gcgccgggcg gaacgcctgc gtcatcaaaa 3943801 cgccgttcca ggttgacgaa tttgttgtat tcttttacga acgcaagaga cacggttcct 3943861 accgggccgt tacgctgttt ggcgataata atttcgataa tatttttatt ctcggtttct 3943921 ttgtcatagt agtcatcacg ataaaggaac gcgacaatat ccgcgtcctg ctcgatactt 3943981 cctgattccc ggatatcaga catcatcgga cgtttatcct gacgctgctc aacacccctg 3944041 gaaagctgag aaagcgcgat aacagggact tgcagctccc tcgcaatcga cttcagttca 3944101 cgggaaattt cagatacttc ctgctgacgg ttgtcctttg aacgaccgct tccctgaatc 3944161 aattgcaggt aatcgatcaa aatcatgccc agcccgcttt cctgcttcaa gcggcggcac 3944221 ttggcacgga tttcactcac tcgaataccc ggtgtatcat cgatgtaaat cccgctgttc 3944281 gataggcttc ccattgccat cgtcagcttg ccccaatcct cttcggtcag gttacctgta 3944341 cggagattct gggcattgat atttccctcg gcacagagca tacgcataac gagctgctcg 3944401 gcacccatct caagactgaa aatcgctacg ctctcatcgg tcttcgtcgc cacgttttgt 3944461 gcgatgttca gggcaaaggc tgttttccct actgaaggac gggcagccac aatgatcaag 3944521 tcgttgcgct ggaaacccgc agtcatccgg tcaagctccg taaaccctgt tggaattccc 3944581 gtgatatcac cttttcgatt gtgaagctgt tcgatattat cataggtctg gacaaggacg 3944641 tccttaatat tttggaaggc actcgtgttt ttgcgctgtg ccacttccat aatcgttttt 3944701 tccgcttcac tgagtaaatc ctcgacctca tcctcacggg tatacccgtc ttgagcaatc 3944761 gttgtcgcag ttctgattaa tcggcgaaga atcgattttt cctcaacgat tttcgcgtaa 3944821 tattctatgt tagccgctgt cggcaccgag tttgcgatat ctgtcaaata tgaaataccg 3944881 cctacttctt ccagcaggtc tgtgttcgca agctctgatg taactgtcac cagatcaacc 3944941 ggttcacctc ggtcaccgag caccagcatc gcattataga ttttttggtg ggacattcta 3945001 tagaaatcat ctggaatcaa tacttctgaa gccagtgtta aagcagacgg ctgtaaaaaa 3945061 atagcgccta acacggcttg ttcggcttct atattttgcg gaggaagccg gtcattcaga 3945121 aggtctgtca tgctaagcac cgtcctctca ttaaaaaatc tccaacctcc attctaccat 3945181 ttctacagaa aaaaaataga aaaattgtct gtttcctgtt tttttcagtt agcagattgg 3945241 atcgtttcgg acagtaacaa ggcgggaaaa atgcaataaa acataaggga ggaatgaaag 3945301 atgataaaga aatatgcgat tacacctaat gttgatgcgg acggctggtt tattgaggtg 3945361 gagaatgtag cgccgacagc tttgtatacg tctaaagacg ccgctattga aaaggccaaa 3945421 caggtggcta aggaaaacag tccgtctaag cttgtaattt atgaccagtt taaaaatgtg 3945481 gaagaagaac actcatttta atgaatgaaa gccttcgctg cagcgagggt tttttagcgg 3945541 ttatcggttt atttcatcca ttggatgcct atgtgcatca tcaaatctgc cgctttttga 3945601 tacagatccc actccccgat cgaagcaaat ttccccatca gctcctgaag ctttaacctc 3945661 attgctatat attcttcgaa agtgacagct ttttcagtgt ctatttggtg ttccttcagc 3945721 atttgtttta ataaggataa cggtgcgtgc ataagaaccc tccttacctc ttttataacg 3945781 gtcattttcc gattgctcta ttcctttgtg acatcttctt acatttcaca tctgattctt 3945841 gtacaatgga cagaagagag gagggatctt ttgtgagacc tttgcaaatt tctgccgaaa 3945901 ctgcacaaaa gcttgcagag tccttgaatc tgccgcttga acagatcatg catatgcctc 3945961 agcatattct gcttgccaaa atggctgaac tgcaaaaaga ggacaaatca tagccttcat 3946021 tcacatactt gcttacctgt ttcgggataa tatcatgtat atgttagaaa agaggagtaa 3946081 ctgctttgcc acatccacat aataaaaaaa tccaatcatt ttggctgatc accggcatta 3946141 tctttatcgc ctttaactta cggcccgcga tcacttcagt cggtccggtc atcagctcta 3946201 tccgggcaga gctgcacatg tccaatgggg cagccggttt tttgaccgca ctgccgctgc 3946261 tttcgtttgc agttctttct ccgcttgcac ctaagcttgg acagcgcctc ggtaatgagc 3946321 gaactttatg gctaggtctc gtgatactgc tgatcggtgt tctgactcgt tctaccggct 3946381 atactgccgc tttgtttttc ggaacagcac ttatcggcgt cgggattgcg attggtaacg 3946441 tacttttgcc aagcttaatc aaacataaat accctgaaaa gccagggatc atgatcagcc 3946501 tgtatacgac atcaatgaat atattcgcag ctttagcatc gggtgtcagc gttcctttag 3946561 cgacccagat gaatggcgga tggaaacaag cctttctctt atggggcggg ctggctttac 3946621 ttgcattgct aatctggata cctcagctgc gccatcgaga tacggcaaac cagacaatga 3946681 agctgcaatc cagttccatt tgggcttcca aaatggcatg gtatgtcacc atctttatgg 3946741 gcctgcaatc gtttttattt tacagcagca tcgcttggtt tcctgaaatt ctccgttcac 3946801 acgggattga tacggcaaca gccggatgga tggtatcact catgcaattt gcgagtctgc 3946861 cttccacttt tctgacgcca gttttagctg accgtgtgaa acagcagcgc ggtatcgttg 3946921 cggcgctggc ctcagtttat ctgatcggcc tttgcggatt attagcgggc ggaagccata 3946981 cattgcttgc catctggatg atcattatcg gtatcggaca aggctccagc attagtctgg 3947041 cccttacttt gattggtctc cgcagtgaaa atgcccaaca ggccgctgcg ctgtcaggca 3947101 tgtctcagtc attcggctac ctgctggcag cagtcgggcc aatctttgtc ggctatctct 3947161 ttgaccagac gcattcttgg acgatgccga ttgtgcttct cattgctgcc ctgatcgtaa 3947221 tgggagcagc cggacaggga gccggacgag atcgatacat tttccagtca gaaaaacaaa 3947281 gaaattcagc ataaagcggg gaagatatct ccgctttttt ctttgaatat ttatggttta 3947341 ttcataagtt tttcatattt gttttttaca atgagacacc ataaagaggt gaaaaacgat 3947401 gaaaaccaaa cgattcgacg cagcccttat tcttattttg ctagcagcag cttttttgaa 3947461 tacgtatcac atttggcagg atgatacagc aaaccagtac tatttggcgg ctgtaaaaag 3947521 catgacgcaa agcttccata acttttttta tgcgtcattt gacccttctg gatttgtgac 3947581 agtagataag cctcctgtcg tgttatggat tcaaacgatt ttcgcactga ttttcggtgt 3947641 tcacacgtgg agtgtcatca ttccccaggc tcttgccgga gttggatctg tcttccttct 3947701 ctacagaatg gttaagccga cttttggagt tggagcggcc cgcattgccg cacttgtcat 3947761 ggcactgacc cctatcgcag tagctgtcag ccggacaaac aatatcgaca gcatgcttgt 3947821 ttttacctta ttgctcggtt caacttgtct gcttagggca gtaaaacaag gcaagctggt 3947881 ttggctgctg acggcatttg ccctgattgg gctcgccttt aatatgaaga tgatgcaagc 3947941 gtttatggta ttgcctgcat ttgtgttatt ctacctgatt gcatctcggg tttctctgaa 3948001 gaaaaaaatc gggtccctgc ttctgtctct tgtccttctg acaggccttt cactctcatg 3948061 ggcgattgca gtggattcag cctcttcctc aagccggcct tatgtaggaa gcagccagac 3948121 taactcagtg ctagaactgg cctttggcta caacggcaca gagcgtctgt ttgggcaaac 3948181 tacgggcctt gcaaagggtg atatgaatgc tgctggcgga gggaacatgc agaatcaaga 3948241 caacatgcaa gcgccaaatg gcaacggttc atctttttct cagaacggta atcaatcatt 3948301 cggaaaccat tcacaggcgc ctcagccgcc taacggacaa accggcgctc tcaatggagg 3948361 cggaggcaca cctcccacag gtggcaacgg acctggaaat ggagggcctg gcggcggagg 3948421 cggaaaaagc gtgaatatgt tcggcaccgg tgatcctgga ccgcttcgtc tcttccaatc 3948481 agcactttcc ggccaaatca gctggatgct tccattctca ttgatcggat tactgggcgc 3948541 aatcatcagc tggtaccgtg atcgccgcgg acatgctgct aaaatgaaag aaacgctatt 3948601 ctgggcggct tggcttgttc ccgtggctgg tttcttcagc atcgcaggat tcttccacca 3948661 gtattatttg attatgctgg caccgccgat tgccgccctt tctggtatcg gatggtatac 3948721 gatgcaccgc ttatacaaaa ataataaaga ctggtccagc tatcttctgc cggcagccgt 3948781 cttgatcaca gccgtgtttc aggtgtatat tctgagcgct tatacaagcc aaatcggcag 3948841 tgtatggatg tatgtcctgg ggctcttagg actgggcatc acccttgcac ttctgatgct 3948901 taaacgcagc catccgttca gtaagctgct gaccatcatc agcttgtgcg ttctgcttct 3948961 cacaccagtt tactggtcag caacgccgct tctatacggt ggcaacagcg tccttcctga 3949021 atccggcccg cagctcaaag gctcagcaaa cggcgggaac atgttctctt cagaggtcga 3949081 cagcgggctc ctgtcctatc tgagaaaaca caataccggc gaagagtatt tatttgctac 3949141 tttgacaacc gtaacagctg cgccatacat catttacgaa aatgaatctg ttatggcaat 3949201 gggcgggttt aacggcacgg atcccattct gactgtgtcg gaactgaaaa aactgatcaa 3949261 agaaggcaaa gtgaaatact tccttctgtc agaaaacaac tcaggcaaca gcgaacttgt 3949321 ttcctggatt aagaaaaacg gaaaagaaat aacatctgac gagtacagcg gttcctccag 3949381 cagcacaaac agcgtgcagg gaatgcgaag aggacctggc ggagaaagcc agcaaactct 3949441 ttatctcgtg gaataaaaaa agaggcttgg atgaatccaa gcctcttttc tattaagctt 3949501 cttcttttac atgtaccttt aacacagcct gcacttcagg atgcagcttc acaggcacgt 3949561 ttgtatatcc taatgcacga atgccgtccg gcagttcaag cttccgctta tctactttaa 3949621 tgttatggtc tttttggagc tgttcagtga tttgcttgct tgtcactgaa ccaaataaac 3949681 ggccgccctc acctgatttt gcgctaagct caacagtcag tttttctaat gtctctttca 3949741 agctcttagc ctgctcaagc tcagcaatgg cttctttttt ctctttctgc ttttgtccgt 3949801 ttaacgcgct gatgtttgac gcgttcgctt caaccgcgag gcctttttta attagaaagt 3949861 tatgcgcata accgtctgct acgtttttga cttcgccttt ttttcctttt ccttttacat 3949921 cttgtaagaa aataaccttc atctctgtac gcctccctca aaatactcat ctatggcgtg 3949981 cttcagccgt tccagcgctt cagaaactga aatgccggac aactgagtcg ccgcatttgt 3950041 taaatgccct ccgccttcca gggcctccat gatgatctga acatttacct cgccaagcga 3950101 ccgagcactg atacaaaccg tttgttcatc ccgtctcgcc accgcaaatg aagcctcaac 3950161 ctcactcatc gatagcagcg aatcggcagc ctgcgcaatc agcacttgat cgaagtattc 3950221 ctcttcattt tcaggaagag aagcaatcgc aatgttatct ttatagagga ccgtatgctg 3950281 gatcagcttc gcccgtttaa tataggaatc aacggtttct ttcagaaact tctgcaccag 3950341 caccgtgtcg gcgccttttg cccttaaata agaagccgca tcgaaagtcc gcgagcccgt 3950401 gcggagagaa aagctctttg tatccactat tataccagct aatagggctg ttgcttcaat 3950461 catattgatt tttaagcgct tcggctgata ttcaagcagc tctgtcacca attccgctgt 3950521 ggaagaagcg tatggttcca tataaacgag cagcggatct ctgataaact cctcacctct 3950581 tcggtgatgg tcgatgacca cgatatgttc aattttattg accagccgtt cctccatgac 3950641 gagtgacggc ttatgtgtat caacgatcac aagcagtgtg tcatcattgg aaatctccat 3950701 tgcttcttca ggcgtaataa atcttgacca cagttcttca tattttttga tttccccaat 3950761 caaacgctgc acacttgatc cgatttggtt tgggtcaatc acgataaaac catctttgtt 3950821 atttgcctga gccaccttta aaatcccgat cgctgcgccg atagaatcca tgtcggggaa 3950881 tttatgcccc atgataatca cattgctgct ttcggtgacg atttccttta aggcgtgaga 3950941 aatcacgcgg gcccgcaccc ttgttcgttt ctccattggg tttgttttac cgccgtaaaa 3951001 cttcaccttg ccgtttggca gcttaatggc tacctggtct ccgccgcgtc ccagtgctaa 3951061 gtccaagctg gattgcgcca aatcgccaag ttctttcagg gaagagactg aagccccgac 3951121 accgacgctt aacgtcagcg ctacaccgtc aaacgaggtt ttttcccgca cttcatcaag 3951181 aatcgaaaac ttcgaatttt cgagttcagt taagatatgt tcattaagta cagcaataaa 3951241 gcgttctgaa gacgtccttt tcaagaagat cccgtactcc tgcgcccaag cgttcagcaa 3951301 agatgtcacc tggctgttca tcgtgcttct cgtctggtca tccaatcctt gtgtcacatc 3951361 atcatagtta tcaaggaaaa tatatgccag gacggttctt tcgttttcat atagcttttc 3951421 aatctggatt tgttctgtta catcaaagaa atataagaga cgctcatccc gtttgatgac 3951481 aaccctaaac ttgcggtcat tcaatgtaac cgtttccgat tccacctctt gtttgataag 3951541 cggcactacc gattcacaag tatcgtaaag tgatctcccc actaaagtgc tttcattaaa 3951601 acaagaggaa agaaacggat ttgcccattc tatataatat tggtcattaa aaagcatgat 3951661 tccaatcggc atttccatca atgcctcttc accgactttt ttcaacctgt aggacaacgt 3951721 agaaatataa gcatcaatct cttgtcgaat aagagaatca gcacgcttaa taaaaaacaa 3951781 aataactgcc agcagcagca cttcgacggt tcctaatatc cagttaaaat aaaagctgat 3951841 gaggattgta ataattgaca gagcaatcaa tgcatagatg ggataccgaa acagcggttt 3951901 ttcataaaag cttggcattt ctatcactcc ccaccatgtg agtaaaactc atgttcactt 3951961 caccttattc cttatatgaa agcccatatc taaaacgcct aaaatgcgaa tggccgccat 3952021 gaagaccgga tgcacaaacc caagtatgac agcaatcaca gccgcagcct ttggatattg 3952081 tttcttatgg caatagaaaa agataaatga taaaccttgg atgaaaatca gaaacccgag 3952141 tataaactcc ccatttaaag cgatagagta cagcatttgg cctttttcta aaggcaaaaa 3952201 tgaaagcatg acaataatca aatacagtac tacaacactt tgcggaaact tcaactctct 3952261 aaaaggcttt agattaggaa tatcggggga gaatcgcctt aagagcggct tagcgataag 3952321 gtaactgagg aaagaaaaaa taactcctac catcacaata gctgttggaa aaagatattg 3952381 aacgataccc aattgttctt ccatcagttt taattgcttc tcaaactgcc cagcattgcc 3952441 cgactgcttc gctacagttt ctacaatatc aagagattgc cggtattgtg tcattgcctc 3952501 atcaatgata ttgataccca aaaactgaat gcttatcaca aaatagaaga caatactaag 3952561 catataaata agagcgcccg aaataatggc gtgcccgggc tctttccttt tgaaaaaatg 3952621 tcccatggca atgccggcgc aagctgacat aaaagctaca ataagcccgt taaaggaccc 3952681 gacaataaaa acaaccggaa gactgacagc gcccatccat atccctagct tcaatccatg 3952741 tctgatcgta tacaagatca ttggcagcgg cagtgcaaat aacagaattg ttccaatcac 3952801 aggaacataa acgaccagaa gcgtaatgat cgcaaacaga ctgattaaaa tagcaccttc 3952861 cattaaagct ctcgtttgtt tcacttagtc acctcgtatc atcctgaaca tacgaataga 3952921 aaagagcagc ataaacgact gctcttttgt tcatcgctgc aacatgcttt gcaccgaatg 3952981 tttttatatc atctctaaat tttactttta tattttaaca taagtccaaa tcgcaagtaa 3953041 aatgacgcta atgtttcatg tgaaacatga aaaaggaaaa gacattcttt gaaaagaatg 3953101 cccatcacaa ttaatgttta tcatccataa agccagaaga ttccttgttt ttctttttcg 3953161 tttttctgac atacataaaa attaagatca ccagtaaaag ggttgttgct tgcagaacgc 3953221 cgctgctaaa caagaaaaag ttctttatca tgtcccacat tgtgtttcac ctctttgtgc 3953281 atgttctcaa cccgtatcct atataaggtg aatttccctt tttaaaaact tcaaaacatc 3953341 atgaacaaca ttgagcgttg ggcatatgct gatatggaat ctgatcgata aaggagaatt 3953401 ttcacatgga tgaacgcaga acattggctt ggcatgaaac attagaaatg cacgagctgg 3953461 ttgcttttca atcaaacgga ctcattaaac tgaagaaaat gataagagaa gtaaaagacc 3953521 ctcagctcag acagctttat aacgtgtcta ttcagggtgt tgagcaaaat ttgagagagc 3953581 ttcttccgtt ctttccacag gctccgcaca gagaggatga ggaagaagaa cgcgcagata 3953641 acccatttta cagcggtgac ctgctcggtt ttgccaaaac atctgtccgc agctatgcca 3953701 tcgcaattac agaaacagca acacctcaat taagaaacgt actggtcaaa cagctgaatg 3953761 ctgccatcca gctgcacgcc caagtttatc gatacatgta tcagcatgga tattatccgt 3953821 cttacaacct ttctgaactg ttgaaaaacg atgtcagaaa cgccaacaga gccatttcaa 3953881 tgaaataaaa caagcagcaa aggagttccc tttgctgcta tttctgctga tccttcacta 3953941 agccgttcga acgataagat tccagcacgt ctctgttgga ttctccccat tctttcattt 3954001 gcaaaacaat cggttcaagc gtgcgcccaa attccgtcag agagtactct accttgggcg 3954061 gcacctggtg ataaacctca cggtgcacga tgccgtccgc ttccagctcc ctcagctgga 3954121 gagtaagcat tctttgagta atactcgggc agattcgccg aaactcatta aatcgtttct 3954181 tgccatctat catgtgataa aaaagaattc ctttccactt tccgccaatg acatctagag 3954241 tgaattcaac tggacagcct tctttgttcg ggtatatatt ctttttttca ctcattcttg 3954301 accctccaat agtacctttt ttgatactac attacatttt gcaactaatc tacccagtat 3954361 tttacacacc ttttctcctt agctcaaaga aaatgcttct tattcacatc aatttttaag 3954421 ggtttgcatg attacacctg cagcaagacg tgttaaacta tataaagatt acactactta 3954481 aaaaaggata ggagctatca tggaaaagat acttattttc ggacaccaaa acccagatac 3954541 agatacgatt tgttctgcga ttgcttatgc tgatttgaaa aacaaactcg gcttcaatgc 3954601 tgagcctgtc cgcctcggac aagtcaacgg cgaaacacaa tacgcgcttg actatttcaa 3954661 acaagaaagc ccgcgtcttg ttgaaacagc tgcaaacgaa gtaaacggcg ttatcctggt 3954721 tgaccataac gaacgccagc aaagcatcaa agacattgaa gaggttcagg ttttagaggt 3954781 tatcgaccat caccgcatcg ctaactttga aacagctgag ccgctttact atcgtgctga 3954841 gcctgtaggc tgtacggcta ccatcttaaa caaaatgtac aaagagaata acgtgaaaat 3954901 cgagaaagaa attgccggcc ttatgctgtc tgcgatcatt tctgattccc tgttatttaa 3954961 atctccaact tgcacggacc aagacgtagc agcagcaaaa gagcttgcgg agatcgctgg 3955021 agtagatgct gaagaatacg gcttgaacat gttgaaagca ggcgctgatc taagcaaaaa 3955081 aacagtggaa gagctcattt ctcttgatgc gaaagaattt acactcggca gcaagaaagt 3955141 cgaaatcgca caagtaaaca cagtggacat tgaagatgta aaaaaacgcc aagctgaatt 3955201 agaagctgtg atctcaaaag ttgtggctga gaagaatctt gatctgttcc ttctcgttat 3955261 cacagatatc ttagaaaatg attcacttgc tcttgcaatc ggtaacgaag cagcgaaagt 3955321 ggaaaaagcg ttcaacgtta cattagaaaa caacacagcc ctcttaaaag gcgttgtttc 3955381 ccgtaaaaaa caagtcgttc ctgtcttaac agacgcaatg gctgaataag caaaaagcat 3955441 cccgcgtcgg gatgcttttt cttattcacc cagcttctca atttgtccca tcacatcagt 3955501 aatttgcttt gcgttttgga ccaggtctga ctgctccaat tctttaagcg ataccttgcc 3955561 ttcctcggct tgtttcaaca catcttcagc gcttttctgc aaggtttcgt tatgctcctg 3955621 aatggttcga tgaatctccg ctgcggcatc aggcggcgtt aattcattaa aatcagcggc 3955681 agccttctga atcgactcaa gctgcgcttc aagtttttct ttcgcctcgg tgtcatttac 3955741 agctttctca gccaattcag gcgcttcctc tgcaaatgtc ttcaccttct ccacataacc 3955801 agctgcttca ctcgtatagt tcaatccgtc gttcacctga tcaagcatgc cgcatccgcc 3955861 tgcactcaaa agtcccactc cggcaagtac tgtcaaaatg atcttcatct tcagccccct 3955921 catcgtttct ttttcatttt ttcttttaag atcggaatca atttctcttt cgctaacggc 3955981 agccctttcc tcaccaattc acgcttcagc cactttttca gcttagacat tctgatgctc 3956041 ctctcccttt ttgataaaaa tgaaaaaact ccaccaattt ggtgaagttc ctgaaacaaa 3956101 aagaccttca ccaaatcaga tttggcaaag gtctcgctaa caatgagatt gccagcaaag 3956161 ccgaggacac cttgtcccgt aatgacgact ttactgtgaa agctactccc ctttggagtg 3956221 ttcattttta ttactttcat tctaaagcac cgatctgttc cagtcaaatt cctgccgttt 3956281 atataaaagc gcgctgtggt atttaaaatt tgaatggttt ttctatcagg agatcatgct 3956341 atgacagagg aggttttcat catgagtcaa gagcgcgtga aacggcctgg gcataccaga 3956401 tggtacatat cttcgttact tagcggcatt attattctta attattttga ccgagtggcc 3956461 atctcggtag cggcccctgc gatacaagat tcgtttcacc ttactgcaac tgaactcggc 3956521 atcgtgtttt ccatttacac ctattcctat acactgatgc agctgcctgt cggaagtttg 3956581 ctggaccgtt ttggggtcgc atgggtcacg agggttggaa tgacaatatg gagcttttta 3956641 acgatccttc ttgctttttt gcaaggaaaa ttgctgttgt atctgttccg gtttctcatt 3956701 gggctgacga gcgcctctgc gttccctgct gcctctaaag caaccgctct ctggtttcct 3956761 ccaagtgagc ggggattggc aaactcactg ttcgattcgg ccgccaagtt ttcaaatgta 3956821 atcggcgcgc cattggtcgc ctttcttgtc acaacatttg actggcgtgt cgcttttttg 3956881 acgattggat gcatcaatgt gctgtttacg atctttttct ggcagtatta tgaacagcct 3956941 gaacggcaca aacgcatttc taaaagtgaa ctaaactata ttcaaaaaca caatgccatt 3957001 acaacagagc aaatccctta caaaacgggc ccgcttttaa aaaagctttt caccaatcga 3957061 aaagtatggg gcttaatgat cggatttaca gggtacgggt atacattcaa cctgctgctc 3957121 acctggcttc cgactttctt taaacataca tacggtatgg atctcatgtc gtccggttta 3957181 tttacggcag tgccgtggct gatctcaacc atttccggaa ttgccgtcgg cggctggctc 3957241 gtcgattatt ttattaagaa aggctatcct aataccaagg tgtaccgaac cgtaatcata 3957301 gtcggaatga gctttggctt tttcttttta ggatccattc tgacgaacaa tattaccgta 3957361 gccattattt gcatttccat cggactcgcc ggaatttccg caaccgctcc ggtcggctgg 3957421 tccatctccg cagaactcgc gccgatcggt tccgtatcca tgctgagctc catggtgaat 3957481 ctcgcaaaca acctgttcgg aggcattatt gctgcgtcac tgacagggta tttgtttgat 3957541 gtgacaggct cctttaccct cagctttctg gtagctggtt ttgtgctgtt gctgggattg 3957601 gttttttatg tgtttgtatt aggggatgta aaacgaatta aactatagaa catgaaaaag 3957661 agagctgcca gttggcagct ctccctttac atcaaagaat cggcccgtcc ccatttacct 3957721 tctcctcgtc ctgttcctct atatcaagcc ccgaagctag catttcctgc tctatctgtt 3957781 cgagcacctg ctcgtttttt ccttgaagac caccttcata atgaaaagca tcctgtgtgc 3957841 cgttttcctc tattgtcgct aaaatatcgt ggatatcatt atggtctcct gaaatggagc 3957901 cgaatccctg gttttgtttt ttataattca caaaaccgct ggggaggttg tttccgaggt 3957961 ttacacatga tgcgctccga gtagtaattc atcagtgtat caaaatcttc attttggatt 3958021 gccacatcac atgcagagat gatgtctttc aattgctgtt ccaaatgaat tcccctaatc 3958081 atcatgattg gatatattat acaatgtttg acacgtaggg atccttttca tttttgtttt 3958141 tacggtttcg ctggtccatt tccgcagagc tggcgccgat cggttccgta tccatgctga 3958201 gctccatggt aaatctggca aacaacctgt tcgaaggcat tattgcggct tcattgacgg 3958261 ggtattttgt ttgatgtgac aaggctcctt tacgctcagc tttctggtag ccagttttgt 3958321 tctgctgctt ggattggttt tttacgtgtt tgtcttaggg gatgtaaaac gaattaagcg 3958381 ggaataaaga gtgcttgtag agaaaacgtt gttctttcta caagcttttt agttttgtgc 3958441 tgtttttcaa gatattcagc tgtcataaaa agaaaatgag ctcccacata ccggctaggt 3958501 atgtggcgtt cttcttcatg ttctggcatg cagctgtgag gaggatttgt ttgctcaccc 3958561 cctgaacctg cgatagctaa gcccgtgcag ttgttttgaa cctacaaagc ttcgttctat 3958621 tttttctttt ctttttttag agatttcctg aaatagaaaa gcaatctttt ctaacctttt 3958681 ctttatggtt ttgccataca taccgagtaa cgactttctg gcgtttcgtt gattttgtgt 3958741 aatattctca aacatatttc aggatttgat ttatatgacc gatagtcttt gcgatcaatt 3958801 gttgagtacg taagtgtatg ctgattcaac aaatgtatct gtattgttca ctttataatg 3958861 aaatttccat tttggaagca aacccctgac tgggtgataa cgtctatgtg cgatggcacc 3958921 aaaaacttgg aggtcaaata gtcctttaga gatgagagtt gttaagtagc cggaatctag 3958981 agcgacggct tctacttgaa aatcaaatca tgcaatttag tgatccaatc ggtcaaggta 3959041 gggcttggaa cagaatcatg gacttttctg gagttgcaaa ctattaatcg tcctcattaa 3959101 atttataata aaaatattct caattgagca aatcgcccac cctttttcct ttataacata 3959161 aaatccaata ctatcaataa aattctttac aggttattac agttaagata taatatagtt 3959221 aatcttttac gtaaaaggag gtttttatta cttgtgttga agttttaaat aggagtaact 3959281 ccatctcccc attacggtct tcatttaatt tcatcctgag ttttatttag ttagatataa 3959341 aaacgaaaat ttcacattat ttttaactaa ccgatagtat aaaatatata ttgaaaggat 3959401 tgtaaaatta tgaataaatt cctgaagagc aatttccgtt tccttcttgc ggctgcttta 3959461 ggcatatcat tacttgctag tagtaatttt ataaaagcca gcaatgataa ctataaattc 3959521 catttacttg taccttatgg ctatggtaat gcctattcaa atgatgcatt tagacagacc 3959581 actcatacag ataatccttg gaaagtaaat ttacagaaat cggcagaagg taaaggtaca 3959641 atcatgacat tttggttgat taacacaggg aatagtaaaa ttccaaaagc ttctaaaata 3959701 cataacgtaa aacaaggaag cggagctcat tattatcatg caaatagcca gggaagccat 3959761 acatatgtag ccttagcagt tgaaaacaac aattacagtg caagttctta tggtatagat 3959821 ggtgtatggg atgaagaaac ttggtaaaca agaaccttct aaaaacgttg gcacctttta 3959881 gccacgcgaa aaaatttaga atgataatct ttttataaga ttatcatttt tatttattct 3959941 attaagaatt gagtgagaac atggaaagtc atatttatcg cattatcaaa aataaattaa 3960001 ctataataat atttactata atcatattaa ttccttgtgt tgatatatca ctattgttaa 3960061 tgactaacac agaataccat cctgcatatg cgtttttcct ttctggcact tccgtagggc 3960121 atgcttcaca aatgatccta ttatggtttc ttccgcttta ttttttgtta ctatgtgctg 3960181 acgattctat acaagattat aaaacaggat atcattacat tcttataagc aaagttggca 3960241 gaaaaaaata ttgtttggaa aaaatattta cctcttttat catttcattt ttgacaatgt 3960301 ttttgtcact aatattaaac tttttattgg ttcaggtttt cttttttaaa ggtacattta 3960361 aaaatgactt agaccaaatt aaattccctg ataacagcct ttatactttt agtatggccc 3960421 atccttatat agcaattgtg ttattttcta ttatttgttg tattatgtct ggatttgttg 3960481 gagcacttgg ttcaagcctc agtttacttt ttcgtgataa gaagtatgcc tacccagcaa 3960541 gtttttttat ttggttcgta cttatactaa aaaacaaatc attaatgttt ttattccaac 3960601 cgtttacaga atacggttat aatgtacttc tccctatcct atgtttgtct atctttattt 3960661 ttctaataat aatttctagt attgttttat atgaggcaaa atacaatgaa aattaaaaga 3960721 ctactattaa ttttatgttt actactattt ttagttactt tatggttcaa ccagaaccac 3960781 acttatcttg gaaagaattc tatcgcgtca ttactatata tgaataatag tacattcgga 3960841 tatagttcaa tatttgcata taccttgttt tatattgtcc cgtttcttat gttacttagt 3960901 aacttttttc attcagaaaa cccctacaaa gtaatgagga tggttaagcg taaaaattac 3960961 tacaagtcta aaattatgga gattgggttt gtttctttac ttttttcttc aatacatact 3961021 gttattaata ttacgtgtac acatattttc tttagtaaaa acttgttggt cgaagcaaac 3961081 tttttatcaa tttgtttatt aaacatgatt agtttagtgt ttttctactt atcagtaggt 3961141 attatgttta gacttacata cgatctgttt aattcagtag cattagcaat ttttattgtg 3961201 tatataattt tagatagctt gtatttcggc gttaaattat tacttcctaa tggatattgg 3961261 gaacccttta gagacttggc tatattcaca aatatgctca atagatattg gtcaacttca 3961321 aatcttataa tagtttatat tagacagata ataatagttt ttatttttta tttagttgga 3961381 tcttcaattt ttttgaataa ggattataaa aaatgaggat taaaggcttt ttcataactt 3961441 tagttgcgat aatatttcag gcgtcattat cgagttataa taataataaa aatgtctttc 3961501 cttttttaga tggcatacca ataagcacct cgggtcatta tgagtatcaa aatattttat 3961561 tgtggtttgt acctattgtt tccctaagtt tttgtttctc tgggagtatt agagatacat 3961621 acatttcgta tgagcaatta aagttagtaa gagaacatag tagagttaaa tgggtaacat 3961681 ctcaattctt aataattaca gttgtacttt taatctttac tttatctcag attgctatat 3961741 tttatattta ttcacttgta tctcttcata accttgatat taattccgtt atcaataaaa 3961801 gatttgttat gatgacactc atgtattatc taaccttact taacttattt agttttcaat 3961861 tatttatgga gctttattat aaatctcaaa tagcacaatt aaatataagc gtttatatta 3961921 ttttttcgtt aattttagca aagaagttag tgcaattaaa ttctccgaaa gttattcact 3961981 actttttaat tccaaactac agtaatggat taagaactgg gttaagctat tattcccaat 3962041 ctggaactgc tattattgaa ccattattag gtttgtttat tataatcatt ttacagattt 3962101 caatagttat attatctgtc ttaaagttca aaaaaataga tatgctaaaa agtgagggct 3962161 tacaatgatt gaggtattaa acctaacaaa aaaaattaaa aagactacag ttttagataa 3962221 tatctcttat acatttgaaa aaggaacaat ttatggacta tttgggagta atggttctgg 3962281 aaagaccatg ctacttcgtg cattatccgg gttaatagtc cctactgaag ggagtataac 3962341 tattaaaggt gaacaattac ataaagatat ctcttttcct aaaagtgtag gattaattat 3962401 agaaaatatg cagttacttc ctcagtatga tgcttttact aaccttaaaa ttttgtcaaa 3962461 aattaaaaag atcgcatcag ataatgatat attagattct attagtagag ttggtttgga 3962521 aaattttaat agtgtaaagg ttagtaaatt ctcgttagga atgaaacaac gattaaatat 3962581 tgcacaggct atttttgaaa aacctgatat attgctactt gatgaaccaa caaatgcgat 3962641 tgatgaaaaa ggagttgcat ttgttcatga cattctttta caagagaaaa aaaggggagc 3962701 taccattatt attactagtc atcacaagga agatattata tctttatgtg acattgcatt 3962761 agaaatgaat catggacgtc tagaaacttc agaaaaagta atatataaga aagatagtta 3962821 gtttaaactg gctatttctt atccaatgat agactgcaga caagttcaac tgctgtaatg 3962881 ctagaaaatc caatgaaatg ctgataattg cgaagagata tgatcagtca gaaaacaaat 3962941 cttaaaaaga aaaagtaaat tcatcaatat ttctaataaa cctggcaaac aacctgttcg 3963001 gaggcattat agctacttca ctgacgggat atttatttga tgtgacaggc tccttacgct 3963061 cagctttctg gtgccggttt tgtgttgttg ctgggattgg ttttttatgt gtttgtatta 3963121 ggggatgtaa aacgaattaa actggaataa agagtgcttg ctgaaaagca ctctttttct 3963181 gcatcgaaag aatacttaag ataagtcact cccaaaaatc gtaacagtct gacggttaaa 3963241 cataaacctc tgcccgttcc attttaatac ggtttgaaca tatcccaatg agtcggcgtt 3963301 ataccttccc gctatccgct ggtacgccaa taattcgtat acgccgtctc tgtcaaaatc 3963361 aaccggatac aagcccgata aaggattcac ccatccttct atcggcattt ttaacacacc 3963421 ttggctgtta taaatctcat tcaaatattc cctgcccttg taagtaaggt cgaggatata 3963481 cgtttcgttt tgctgatgac tgataacgct cgctttatat tgattttgat acctcacact 3963541 gtactttaat tcatcattca atacatctga attgaaaatt cgccggaact gcctgtttag 3963601 ataggcaaac acatatgcat aaatagcacc gccgcttccc cctgtgtcca ttactactgc 3963661 cacatcctca atcttgtcgc ctgtcatatc ccccagaaaa agtgacggat tgtatcccat 3963721 attgttttga agctgaatcc gctgctcctg atgggttctg ccatcacgga tcaccaatgt 3963781 gatatttctc cataacgggc tgccgggcat ttgatttcca gttagaaaga cctcgtcaat 3963841 aacgccgtct cccgttacat cgccgcgggt agatacaatg attgcacgtg aggagacagg 3963901 ctgccgaaat acgtatggat gttgaacaag tcctctgcct tcataaaacc aataaggagc 3963961 cattctgatg tcatacacat tcaattgtgt caccttccct aatcagctga atgaatcatt 3964021 atatgcagga atggcacatc aaagacatat cttacacacc aattaaatcc gtaccatatg 3964081 aattatcaat tacacaaagc cactcgcctt gcgcattctt tttaaataca taggtcgccc 3964141 ttctttccat cgcatactcg gagtcctttt tatccgaatc aagcagtgtc tgagaaagaa 3964201 cgagtaccgt gtcacctgct tccaacagga tcattttccc ttgtgtcggg acaatatgat 3964261 gattgaaata gttcgcaatc gtgataaacg cttttttgat ttcttccttg cctcgcgcga 3964321 tcatgcccgg cttcacaact aaaacggcat cttccgaata ataattcatc agtgtatcaa 3964381 aatcttcatt ttggattgcc aaatcacacg cagagatgat gtctttcaat tgctgttcca 3964441 aatgaattcc cccaatcatc atgattggat atattataca tcgctagacc actgaaacct 3964501 tgaaaacaaa atgaaaagta tccttttttc ctatataatc aaatagatat atttaacaaa 3964561 gtacccaagt gaaggggtga acattattgt ctgcggaagt aacgttacat gacaatatac 3964621 attatgattt aagtgcggat tgccagcact gttttggcct gtgctgtgtc gccttgcctt 3964681 atgcgaagtc ggcagatttt gcttttgata aagacggggg cacgccttgc cgcaacttac 3964741 aatcaaacta tcaatgttct atacataaag atctcagaga aaaaggattt cgaggctgct 3964801 ctgcatatga atgctttggc gccggccaaa aagtatccca aatcacttat gagggaaagg 3964861 attggcgaaa cagccccgaa acggccaacc agatgtttga cgtttttcct atcatgcagc 3964921 agctgcacga aatgctctgg tatttacatg aagctctttc tatagatata gccaagccga 3964981 ttcattctga actgagaacc actttcgaaa aaatagaaag gctcaccaga ctcagcaaag 3965041 aacgcttgct gacactgcag gtggacgagc atcgagctga ggtcaatgaa tggctgttaa 3965101 aaacaagtga actggtgcgt gcccaagccc gccatccaaa actcccgaaa aaggtcagcc 3965161 ggggaagtgt cctgatcggc gcgaaactga aagggcttga tctgcgagga gcaaatctaa 3965221 gaggggcgct gctcatagcc gccgatctga gaaatgccga tttgagaatg acagacttta 3965281 tcggtgcaga tatgagagac gctgatctca gcggcgccga cctgaccggg agcatctttt 3965341 tgacacaggc acaggtgaac gccgccaacg gcgattcgaa tacaaagctg ccgctgtctg 3965401 tacgaacccc tgcccattgg aaataaaaaa ggacccgcta acggtccttt tttactgatc 3965461 aattcaatcc tttttcgttc ctcttatccg gcattttcac acttcttgcc aagtatcccg 3965521 acagccataa cgcaaccagc agcatgaagg tgatcatacc gacgacgccc agccagtgaa 3965581 aaccagacca gaatagccct ccgattgttc cgaaaacact tgaaccggcg taataaaaga 3965641 acaaatacag cgatgaagcc tgtgctttgt tgtgaagggc tctcctgccc acccagctgc 3965701 tggcaactga atgccctccg aaaaaaccga atgtaaagag ggcaatcccc agaattttca 3965761 ctgccagcat attgtttatc gtaaataacg cacctgcaat gacgatgaaa atattcatca 3965821 ccaatatttt cggatagcca taccgatcaa ccattcttcc aatgaaagac gagctgaaaa 3965881 tgcctacaat catcacaata aagatccagc tggaaaatgc tttattaagc gaatacggcg 3965941 ggcccaacag cacatacaca atgtaattaa acaaggcaac attgcttcca agcagcaaaa 3966001 aaccaatgag aaacaagctg aatagtttac ggtccctcaa gtggccgatc agagacattc 3966061 ccaatttccc gagcttcaat tttcttggcg taaaatgcct ggatggcggc aaatttataa 3966121 aaaatataac actagcaatc aaactaatga caccaattgt ccccatcgcc atatgccaat 3966181 tcaagtactc gctcaggagc ccggaaacga tccttccgaa aacggcgccg attgcatttc 3966241 cgctgatata tagccccatc gctgatccaa gacttccggg ttcaatttct tccccaagat 3966301 aagccatcgc aatcgacgga aggcctgcga gcgcaacgcc ttgaatggtt ctcaatacga 3966361 gcagtgtatg aaagctcgga ctaaaggccg atgccagaca gagaaccgat gcggccagca 3966421 tggaaatacc cataataggc ttgcgtcccc acacctcgga taatgaacca aagacaagca 3966481 tgctcacagc taacagcatt gtggtaacag ataaagaaag actcgccgca gtaggcgtta 3966541 catgaaattc ccgcgtgaat tcctccatga gcggctgtac gcaatataga atcgcaaatg 3966601 tattgaaacc cgcagcgaag aaagcaaacg taatttttcg aaaaaccggt gtgccttttc 3966661 gaatgtatgt catcgggact ttatcggtcc ctcatcatgt tgtggagcac tgccattcat 3966721 aaacaatcat cctttatttc ttacgaattc aaacatcctc gagtctgttt atattattat 3966781 cttagcaccg ttgatatatg ttgtataatg catataaaat atccttttca tgcttatatg 3966841 taataaggag agatgataat tggaatggga acaacttgaa tattttcaaa cactggcccg 3966901 gatgcagcac gtcacgaaag ccgcaaaaag cctctccatc acacagcctg cactttcacg 3966961 ctctatcgcc aggctggaaa atcatttggg cgtcccgcta tttgacaggc aaggacgatc 3967021 catcagctta aatcaatacg gacacatttt tttacgacgg gttcaggcga tgatgaagga 3967081 gtataccgaa ggaaaagaag aaatccaagc cttattaaag ccagaccaag gcgtagtctc 3967141 tctcggtttt ttacatacat taggcaccac gctcgtgccc gatctcatcg gctcctttca 3967201 gcaggaatac cccaacattt ccttccagct gaagcaaaac cactcttatt ggctgcttga 3967261 acgattaaaa tccggagatc tggacctctg tctcctcgct tcgattaagc ctgaaaatcc 3967321 gatccaatgg atcaagctgt ggagtgaaga actctttgta tttgtgccaa atgatcaccc 3967381 attagccagt cgcgaaagca ttaccctgaa tgagattgcc ggggagcgtt ttattttatt 3967441 gaaaaagggc tatgcgcttc ggatgacggt cgatgagctg tttgagaagg ccaatataca 3967501 gccgaacatt atgtttgaag gagaagaagc aactactgcc gcaggttttg tggcagccgg 3967561 tctgggcata tctattctcc cagacctgaa aggcttagac caaagcaaaa tcaccaaaat 3967621 ccgcgtcagc tggccggaat gtcagcgtgt cataggaatt gcctggataa aaggcaggtt 3967681 tttatcaccg gttgctgaga cctttaaaca atatgtgatc agccattttt ctgagtagga 3967741 aggattcaag catgaatgtc aaaaaaatca cgtcagaaca ggatttacat acagcgtttg 3967801 aaatcagaaa ggcagtattt gtagaggaac aaggctgtcc catttcggat gaattcgatg 3967861 agttcgatac actccacggt gactgccagc acatcctggc ttatcatcag aatgtacctg 3967921 ttggcactgc acgtgtccgt atcgttggcc acacggggaa actggaacga atctgcattc 3967981 tgaagtctta ccgcaaattc ggtttgggaa aagtgatcgt cgatgcatta gaacgtattg 3968041 taaaagaaca aggcatttct gccttcaaac tgcacggcca gacacaggcg gcaggctttt 3968101 atgaaaagct cggctatcgg actgcatcag aagaatttat gctggacggc attccgcatg 3968161 tgctgatgac aaaacaagac gattctgcgc tatagattgt tcacaaattt gtcacttatg 3968221 agcatgaacg gttcattggt atactaatca ccgattatgg agagaaggaa tgattgtatg 3968281 ccagcaaata aaaaagaagg ccttatattt ggcgtgatga tgtgctttgg aatggtttgc 3968341 gtcatgtcga tttacaatgc catcatcaac cgagccatct acgatttttc actgatgacc 3968401 gtttttgaaa tggtcatcgg ttttatgatc gccctcctgt tagatttact gttagtgggc 3968461 cccctcgcca agaagattgc attccgcatg ccgttcgaca agactaaaaa aatttatgtc 3968521 atccttgcca tgtcaacttg tatggtgatt ggcatggtac tttgtatgtc tgtgttcggt 3968581 ttagtgacag cggttctagc aaatgggctg aacggggaca gcctcttcag tgcttatctt 3968641 atgattgtgt tgaaaaattt catcctggcc tatccgttgc aattactgat tatgggccca 3968701 ttagtcagag gagttttcat gaaatttgta aaaccaaagc tcacagccgc aatttaaata 3968761 gaaaaggagt gagcctgaca ctcactcctt ttgctcatga atcgaatgta aaacaagctc 3968821 cgcaaaagcc tctgcggcag gcagctgcca ttttttcttt ttgggtgtga gtaaatcgga 3968881 tcgagggctt caccatgctg gagatttttc agcttatgtt tttcacttcc attaatccct 3968941 ataccttacc acatagtttt tatacaattc ttcgttataa aggatttctt cgccatgtga 3969001 agagcaaatg agcgttggtt tgatttgatc tatgattgag ccgctgtcga tgttctcatt 3969061 tatatcaaca ctgaatcttc ttataggtgg gtgtaaatcc tccttacttg tgataaaaag 3969121 gtcgcccgtc aatagcgtac gatcgatttt atgataatac acaacatgcc ccggcgaatg 3969181 gccaggtgtt aaatagtatt tcagaggcag atgagcaagc gtttgctccg tcagcggctg 3969241 tacaatatgg gctacccctg tgttctccac ttcatttttg ttcggatatg gctcttcccc 3969301 attgatgtac tttagttctt tctggtgcgc aaaaatcgga atatcaaatc tctctaacca 3969361 ttttgatgca cccccgatat gatcactgtg gccatgggta agcaaaatgg cttttggatt 3969421 gccgatcgct aacgctgccc taatttgagc atcagcaaaa cgttctattc ccgtatcaac 3969481 aatataaaca tcatcaccat ctttgataaa ccaggtatga accggaatac gaagaggcac 3969541 atcaagctca aattcacatt gaaagacatg ttctgatagt tgtctcaaat tcacgcaaac 3969601 catctcctgt ggaaattttt tgatagtttt aaagaaaaca gaagtgaacg gactattttc 3969661 acccacgctc gagctgactg gattcttgag aggaaacgcc gattttcgcc agcatcagct 3969721 caacttgtta acgttgtcca ttaataatcc cttttgttcc ccttcttcac atattcccaa 3969781 tcacgttcta tattcttcct cactctatga aggagtgcag aaatggtttc cttttcctct 3969841 gaagtaaaac cggacaaggc cacttccgtg gaatgttctc cttctcttct taacaatgga 3969901 tatacctttt tccctttctc agtcgggaac agttttttta tttttttatt ttgctcatcc 3969961 ggcagttttt gaataaatcc ctgcatttcc agcttcttaa tggcccgcgc ggccgttgtc 3970021 cggtccactt ttatcatttc cgccaatttt tcttgaataa ttcccggatt ttcgtatata 3970081 cgcacgagat agagatactg ccctcttgtt aagtctaaat ctttaaattc gatgttgctt 3970141 atggaatcca acgctcttgc tatcatgccg atctcacgca aaatatcatt cattcctaaa 3970201 acccctcacg tatttttgtt gcaattacaa caaaaatgtt ttaaccttac tattataaga 3970261 ccacatgcgt gctgtacagt ccagactaat atcagaaaag gattgattca taatgaatat 3970321 aaaaagaata acaactgaag ctgatttaca tgaagcttta aagattagaa gaggcgtttt 3970381 cattgaggag caacatgtgt ctgaagccga tgagttcgat gaatttgata cgcttcagga 3970441 acaatgccag catatcttgg tatatcatga gaatcagcct gtcggcaccg gacgcgcgcg 3970501 catcgttggc catacagcaa agctggaaag aatctgcatc ctaaaacctt accgtaagta 3970561 cggattgggg aagatcatcg taagcgggtt agaggaaatc atgaaagaaa aaggactgac 3970621 ttcatataag ctgcatggtc aaacacaagc ggcaggcttt tatcaaaaac tgggctacca 3970681 gatttcttca caggaattta tggaggacgg catccctcac gtcttgatga caaaagaaat 3970741 atcgcggaat ataacatgaa atatatgtat tacggaatag gcatactcat attaagtttg 3970801 ggcatttcct taaccataca atcaggactg ggcacatcac ccttcgatgc ccttttggtt 3970861 ggtctgtcaa aaaaaatcgg tcttaccgta ggaagctggg aggtccttat ttctgtgatc 3970921 ctcttaatct gcaacgctat attaacgaga aaaaaaccta ttttgctggg cttgattaca 3970981 gcattcatta ctggaatagg cattgaccta tggttgtttg ttgtaaaaaa caccatctat 3971041 ctaaactcgt tgttaagcaa actgatttgt tttggaattg gtttggtgct catcggtctt 3971101 ggaacagcca tctatcttca gacgaaattc gcatcaacac cgatcgatca tttaacactt 3971161 attatccgag atctctccaa aagaacaata ttgttttcaa ggacattggt atacgctctt 3971221 ttcttagtat tagccatcat ctttaaaggc cctatcggca tcggaactct tttaacggtt 3971281 tgtttgggag gaatgctcct tcacgttttt atgcctattg tggaaagaca tttcttatca 3971341 aagaatagaa gaggttatta agaaacctct tctcgatcca aaaaacgaaa cgcaaaacaa 3971401 gccccgtttc gttgtcaatt ctttatctct ggtactgttg aggttttata atcaattaaa 3971461 atttatagta ccaaaaaatc gcaatttcat ttgctgttgg aaagttggaa taaagcatcg 3971521 tatcaaccgc acctattata aagtgatgtt tggcataaaa atgacaagct gaaatattaa 3971581 tatcttgggt ttcaagcata agaccacaaa aatgattctc ctttgcccac tcaatcgctt 3971641 tatgtaataa tgctgttcca acaccttttt ttctatagtc ttttgccacg gcaatgtcct 3971701 ctattagtgc atacccattc cagttagaac ggatcttaat ccggccaatg cagttgtttt 3971761 caagataata taaaaaagcc gctttcccct cttcttcaac ataactaaca tccatgtcat 3971821 catcttcata ttgtttaaaa taaggtttag aaaatcgttc ctcagtatat gtccaaacac 3971881 cgttttcaaa agcaggtatc attctcccaa aaacaacgaa aggttcgttt ggtttattga 3971941 aatctttcat attcaaatga gtcattttca tgatcatatc aatctccgcc aatcgagata 3972001 atatttagta aactcgtttc gatactattc aacaacagct tccaaaagtg tactctttaa 3972061 gagaacagca ttagataagg catccattac cttatatatt tcactatctt aatgaggtat 3972121 ttcaacagag gcttgtggta cagtaaaaag gaatagaaac aagagaaaag aagatgaacc 3972181 tatgcccact aacaataaac tcaatgagaa atatcatact tccttcaact cgcccacaac 3972241 cctgttgact agtatccgtg gagagaggaa gctttgacac agcttctgcc attgatgaca 3972301 tctctattga agtatccaaa ggacaaccaa ggatcgctct ttgacttttt caagaagaaa 3972361 gtagagtgaa taaaggagtg attgagtatg ttaacaagag aagatatctt taaacacgtc 3972421 aaagaaaaat acggtacatc gcctgattac ccgtgggaga aatacccaaa ctatgcttct 3972481 ttgagacata catcaaacaa aaaatggtac ggtcttatca tgaatgttct cccagaaaaa 3972541 ttaggcttgg atggtcatgg cgaaatagat attctaaatc taaaatgtcc ccctgaaata 3972601 agtgatcgct taagaaacgg ggaaaatatc ttacccggat atcatatgga taaggaacat 3972661 tggatttcaa ttgttttaga acggacagat ccagaaggcg aaatctataa cttaatcgag 3972721 cagagctttc atttaaccaa gtgaagataa agagtgttcc tgctaatcaa gctgcgaaga 3972781 gtagtgggca ctttcatttt aggatactgt tcttcactct gtccacaaac gcaacttagt 3972841 tcatctggtg cgagagtggg agaagaattt caaccaactt cttatgtaaa aggatgaata 3972901 gttatgacaa ataacttaaa acagagaaga atcattttag atttagcagt tactttagat 3972961 ggttttattg aagggaaaaa tggagaagtt gattggtgta ttatggaccc tgatatgggg 3973021 tttactgatt ttttaaatca aattgatact attttatatg gtagaaaaag cttcgattta 3973081 tggggacaat acattccaaa aaatgaagac cctgatacag aaaaggaact ttggaaattg 3973141 gttcatagta aaaagaaata tgttttttcc agaacacaaa atgagattga taatcaagcc 3973201 atatttataa atgataatat tcttgaagaa gtaaataaat tgaagaaaaa tcctggtaaa 3973261 gacatctggc tatatggtgg agcgagtctc attacaactt ttataaattt ggggcttgtt 3973321 gatgaattta gattatctat tcaccctgtt gttttgggag aaggaaaacc gttgtttatt 3973381 gatgtaaaac agaggataaa tttaaaaatg gtgaatacaa gaacattttc ctctggcgtt 3973441 gtgcaaatcg tttatcattg gaatggctaa cattgtaaag taacactcga cagtaatcct 3973501 tcttattgaa ctaaagggga atccataaat aatgggttcc ccttaatata ctatggaatt 3973561 atcaatatca aattttctgt aataaaagag gattgaaaag gacgatgtct cctcaattaa 3973621 catcattaag cattatagta tattttcttc tccctctttt aagtaatcgg ctaagttttg 3973681 tatttataaa aaaacgaaag aaggtgatcc aatgcctact aacaataaac ccaatagatt 3973741 aatcgctgag aaatctactt attttacttc aacatgctca taaccctgtg gactggttcc 3973801 cttggggaga agaagcatat gaaaaagcga aacgcgaaaa caagcctgtt ctcgtatcta 3973861 ttgggtatag ctaacgatgg ctaatctaaa gaacatgcta ttgatgccat gtttattcat 3973921 tttacaaaaa aggatcaacc ttgaattact ttcacaagat tgatcctttc actcatttag 3973981 ccatgtctcc gcgaacgttt atatacattc aagattacta gccaacaaat aacaatgatt 3974041 cctgcaaaaa gtatgagcat attgctatac aaataggtag agtgatcaac gtcaataggc 3974101 agcagcctat gatctaggaa gccgatagat aataaaccgc ctacaatcgc aatacccgtt 3974161 ccctctgata aaaagctcgt gaaattaagc aaactcattc cagcgcccgc ttccttttct 3974221 ttcaaactgc tagacacaac tgtagatata actgtttttg tgaaagatag ccccccaaaa 3974281 acaaaaatta ctataattgt catgatccat ggtgctgcat ctataaaaaa ggcagcgatt 3974341 aaaaagccgg aagaaagcaa tgcacttcca atagttagta catacaagga acctttccga 3974401 tcaacaagca atcccccaat gtaaccaaag atgatgacac tcattgttcc ggggaaaata 3974461 atgccgcttc caattgctgc agtacttaaa tggtgaacat ctttcatcat gtaaggaacc 3974521 atagagacaa atcctgctac tgtaccaaat attagtcctc cgcaaagggt tccaatcaca 3974581 aaaaagacgt ttttccctaa ttcagggtca acaaaagggt cctgagcttt cctaatgtgt 3974641 tgcacaaata tgaagaaagc aaggatactg atgatcagaa aagaaaatct ataagatgtt 3974701 gtaaacagca taaaaaatac gatacctgca gacatcaata taatccctgc catatcaatg 3974761 tgtcctctta ttctctcttc ctttttcaac aattttataa ggaatggaac ggtgataatt 3974821 gttgcagttg gaataagcag caaatacgac caatggatat aatgagcaac cattccgcca 3974881 atagctggcc caacaccttc tcccattgct accagggacc cgatcaggcc aaatgctttc 3974941 cccctgttct cttttggaat atagcgcgca acgacaacca tcacaagagc tgggaatgcg 3975001 gctgcaccaa ttccttgaat aaatcgggct agaatgagaa taggaaagaa agagtgtcca 3975061 acaaatccaa tgatcgaccc taagccattt accataatcc caaatagaag cagatttttg 3975121 atgcccagct ggtctgatag ctttccatat agagctgttc caatggagaa ggttaacata 3975181 aaggctgtat tcacccagtt tgcacttgct ggcagtttat taaactcgtt ggcaatatca 3975241 ggtaatgaga cgttcagaac catttcattt aatacgctga aaaatgatag aacacaaagc 3975301 caaatcaaaa cttgattgtg ccgtaaagtt gactgtgaat aagacgtatt cacaatttcc 3975361 cctccattaa tgagggcaga cgcagtttat agggtcattg atacgcttcc ctcttttaat 3975421 tgtaccctgt tcattttatt gcacttcata ataactcccc ctacatttga ttgatatgat 3975481 cttattatat atagactaag gattaaactt ttactttttt tataaaaatt tgaccagatt 3975541 gcgaaacaag gaaaaacgtt attcgcattt atctcaagtg gcaaaatgaa acattagttt 3975601 atattttcac atcacaatta tcgataagca gtcagttatt gtatttgttt aggataactg 3975661 tggtaacctg aatataacca acttaggaag aaggtgatcc catgccaaat aaaagtaaac 3975721 ccaatagatt aatcgctgaa aagtctcctt atttactcca acacgcccac aaccctgtgg 3975781 actggttccc gtggggagaa gaagcatttg caaaagcaaa acgcgaaaac aagccggttc 3975841 tggtcagcat cggttattcg acgacttgtc attggtggcc tgggataatc aaatcgtgtg 3975901 gaactccatt aaaagataac agaagccatt ttaaacgata atactatttg ttcaaacaat 3975961 acagtctacc ttttatttca ttcattttct aaaacctgta atccgtaacc acgcggtagc 3976021 aggttttttt atttgcttga cttagagtta actctaaatt gtaaactaac tttaattaaa 3976081 tgagagggat gatgttgttg tattccatta gtaaagctgc tgagaagact agtattagtt 3976141 cgtatacatt aagatattac gaaaagattg ggttacttcc accaccaaaa cgaaaaaaca 3976201 gtggaaggcg tttttatacg gagactgata ttcagttcat gttattcctg aaaagtttaa 3976261 aggaaacagg tatgtctttg gaggatatta atgagtttgt caaagacgga tgcattttgg 3976321 aaaaaatcaa ttcggatgtt aaatcggcac aactctcccc atctataaat aaacgtattg 3976381 agattttaac caagcactta gagaaaatgg aaattaaaaa aagggagctg gaagaagtga 3976441 tttctactac aaaaggaaaa ctggatacat attattcaat tttgaaagag gaagtggaaa 3976501 acaaatgaaa catttaaata tatacataat gttacttggc ttctctattt tcacgggagc 3976561 tacttttaat cttgcaaaat atacagttgg atatttttct ccatcgtctt ctgcggcatg 3976621 gcgtttcggt ttagcggctg cagtgatgct catcattttg atttttactg aaggtataaa 3976681 gaagagtcaa ttacggaaaa acgccgtttc atacattgtt cttggaatta taggaatctt 3976741 tggatttaat gccttgtttt ttgttggttt aaaatataca tctcccgtta acggagcatt 3976801 aataatgggg ctgaatcctt tattaacagc aattctcgct cgaattatct taaaggacaa 3976861 catgacaaaa aaacaagtac tcggcatatt ctttgcattc atcggtgtat tgttagtcat 3976921 tacacaaggt tctatcgaaa ccattaaaac cttatcaatt tcaggaggag acttaataat 3976981 ctttacaggt aacgtttgtt gggcacttta tggcgtactt ggacgtcggt ttgtaaagga 3977041 tggtacaccg ctatctacaa ccacttatac gatggttatt ggtgctgtta gtttaatagt 3977101 agtttcctta tttacatcca aacctgtttc tttatcgaac atcccgattg gagtttgggg 3977161 ggcaattgct tttatggctt tttttacaag tgttttgggt tacctatggt ggaatcaggg 3977221 gattaaagag attggagcta gtaaaacatc tttatttttc aaccttgttc ccgttgtaac 3977281 gatgattatt tcatttgccg ttggaacacc aataaaggta tttcaagtta ttggggctgt 3977341 gctagttata ttaggcgttt taaccgcttc gggggtaata cgtattccta agtacaatac 3977401 taaagaacag tcagctatat aaagaaatag ggagtatttt tgagaaaatg tgttaagtta 3977461 aatatacact aattatagga agaaggtgat cccatgccaa acaaaagtaa acccaataga 3977521 ttaatcaatg agaaatcacc atatttactc caacacgccc acaaccctgt ggactggttc 3977581 ccgtggggag aagaagcttt tgaaaaagca aaacgcgaaa acaagccggt tctggtcagc 3977641 atcggttatt cgacttgtca ttggtgccac gtgatggccc acgaaagctt tgaagacgaa 3977701 gaaatcgcgc gtcttctcaa tgaacggttt gtggcgatta aagtcgaccg ggaagagcgg 3977761 cctgatgtgg attctgttta tatgagaatc tgccagctga tgaccgggca gggcggctgg 3977821 ccgctgaatg tgtttatcac gcctgatcaa aagccgtttt acgcgggtac atattttcca 3977881 aagacgagca aattcaatcg tcccggtttt gttgatgtgc ttgagcatct gtctgagacg 3977941 tttgcgaacg accgcgagca tgtcgaggat attgcggaga acgccgctaa acatttgcag 3978001 accaaaacag ctgcaaaaac tggtgagggc cttagcgaat cagcgattca ccggacattc 3978061 cagcagcttg ccagcgggtt tgacacgatc tacggcggtt tcgggcaggc accgaaattt 3978121 ccaatgcctc atatgctgat gtatttgcta cgttatgatc acaatacagg gcaggagaac 3978181 gctctataca acgtgacgaa aacattggac agcatggcga atggcggcat ttacgatcat 3978241 atcggctatg ggttcgcccg ctattcgacc gatgacgagt ggctcgttcc ccactttgaa 3978301 aaaatgctgt acgacaatgc gctgctgctg accgcttata cagaagccta tcaggtcacg 3978361 caaaacagcc gctataaaga gatttgtgag cagatcatta cgttcattca gagggaaatg 3978421 actcatgaag acggaagctt tttctcggct ttggacgcgg acacagaagg agaagaagga 3978481 aagtactacg tgtggtcaaa ggaagagatt ctaaaaacgc tcggggacga tctcggaacg 3978541 ctgtattgcc aagtgtatga catcactgaa gaaggaaact ttgaaggcaa aaatattcct 3978601 aacctcattc acacaaagcg agaacaaatc aaagaggatg ccgggttaac cgaaaaagag 3978661 ctcagtctca aactcgaaga cgcaagacag cagctcttga agacacgcga ggaaagaacc 3978721 tatccgcatg tcgatgataa agtgcttacc tcatggaacg cgctgatgat cgcgggtctt 3978781 gcgaaagcgg caaaggtata ccaggagccg aaatatctca gcctagcgaa agacgccatc 3978841 acatttattg aaaacaaatt aatcatcgac ggccgtgtga tggtccgata tcgtgatggc 3978901 gaagtgaaaa acaaaggctt tatcgacgat tacgcttttc tcctatgggc ttatctggat 3978961 ctctatgaag cttcgtttga tctttcttat ttacaaaaag cgaagaaact gacagacgat 3979021 atgatcagct tattttggga tgaggagcat ggcggattct acttcaccgg acacgatgca 3979081 gaagccttaa tcgtacggga aaaagaagtg tacgacggcg ccgtgccttc aggaaacagt 3979141 gtggcagctg ttcagctgct gcgtctcggg caagtcacag gcgacttatc actgatcgaa 3979201 aaagcggaaa caatgttttc cgtgttcaag ccagacatag aagcgtatcc gagcggccat 3979261 gctttcttta tgcaaagtgt gttaaggcat ctgatgccta aaaaagaaat cgtgattttt 3979321 ggcagcgcag acgatccagc cagaaaacaa attatagcgg agcttcaaaa agcctttaag 3979381 cccaacgact ccattctggt ggcagagcag cccgagcaat gcaaagacat tgcgccattt 3979441 gcagcagact accgcatcat agacggcaaa acaaccgttt atatttgtga aaacttcgcc 3979501 tgccagcaac cgacaacaaa tattgaagaa gcgatccaca cattaataag cagcagggat 3979561 taagaccctt gctgcttact ttttgatttc ttatggtacc ataaagcgat ccccgcaaac 3979621 acaaggttga ccgctatcgt aaagaaagcc tcccacatcg ggttcccccg cgtaacggta 3979681 aacagagaag gaattcctcc atacacactg tttttttctg taataaacat acacaaaaac 3979741 atattattcg cggcatgggc gccaagtgat atttcgatgc tcccagtttt aatcgtgtaa 3979801 tacgtccaca caaacccaaa tgttaagtac tcaattcctg cccagacagc gccattgttc 3979861 atttctggat tcgcaaaatg caatacgcca aacaatcctc cgacaatcag tgtcaaaaat 3979921 agaggatttt tcgtcaatct cccgaaagct tgaagcaaaa atcccctgaa aaatagttcc 3979981 tcagctgatg tctgaatcgg aaccaaaatg agggcagccg ctagcagcca gataaatcgt 3980041 gatgcattaa actcttgcat tgaatagcta tcaggatgaa tcacaaaatc aatcaattgt 3980101 acggcgatca ttagcaagaa ataagcaata aaaccaaagg aaattctccg ccaattcatc 3980161 tttgaatttg gtgttatcac cgttcggaaa ggccgcttca aaataaagcg cacagccagc 3980221 caaactcccg gaatggcgaa taaataaatc acatgggaca aataaagatc tacgagggga 3980281 tcactcagca cagcttcatc caaatcaaac gtgatattgg gattcacaat aaccgtgaac 3980341 aatatagcga aaaggtaagc tatattccct aatacatata accctaccat caccaaaaaa 3980401 gcgaaaaaat atctccacaa cgtattgttt ccttctatag gacggataaa tgaattcatt 3980461 ccttctatgt ctcttccttt caatgagaat attactatat atttgcataa attggtctat 3980521 gaatctactg ttttggaaat cttttaagca aaattaaaat ataaagtgtg aatttagttc 3980581 ttccatctag tgatttgaac tctgttgcca atgaaccaag atacttataa tagtcccaag 3980641 aggggaattt tcagtctttt ctactactca aaagggggtt ttttatgaat acgatcttca 3980701 aacaaaagaa tacacatcct ttctcaaacg cagcgaatcg tttagaccgc cttccgattt 3980761 cacgcgttca tttccaagtg ttaaccgctc tcggcattgt ttatttcttt gatctcgcag 3980821 atttatttac cctcagcaac gtagcgccgg cactgatcga gcattggggc atcccgcttt 3980881 caactattgc taacgtaacg gccgcttcgt ttttaggcat gtttttaggc gcttcactgg 3980941 gcggacggct gtccgatcga atcggccgca aaaaagcctt aaatctattt gtctttgttt 3981001 tctcaatcgc atcgctatgc aatgctgcgg catgggacat tccatcttta atgacattcc 3981061 gtttcctcac cggatttggc gttgcagccg ccatggtcat tacgaatagc tatttggcgg 3981121 aatttttccc ttcaagtgta cgtggaaaat atatttcttt ttgtgccatg attggattga 3981181 ttggggttcc gatcaccaac attgtgtctg cctttgtcat tcctcttggt tcatggggat 3981241 ggaggctagt atttgtatgg ggtgccgtcg gccttattta ttttttcttc atccaccgtc 3981301 tggaagagtc acctcgctgg cacgaaaatc gcggggaata tgcgaaagcc gatgcgatcc 3981361 tcacccgaat tgaagaacag gttgaaaagg agaaaggccc gcttccggca gcatcccagc 3981421 ctaaagtaag cgaaactgtt aagcagaatg caggttacgc aggcttattg aaaggcagaa 3981481 acctcaaaat taccatcgta ttatctgctg tatggatttt tgaaacgttt gggttttacg 3981541 gatttgcttc atgggttcca agcctgctaa aaagcaatgg cgtaaccatg gaaaatacat 3981601 tatggtataa cgtattgcat tccgtcggcg ctccacttgg cgcactgctc ggctccatga 3981661 tttccgaaag atttcaaaga aaatggattt tagctgcgag tgcgtttctg acggccatcg 3981721 ccgggctctt atatggtatg acttttattc ccatcatgat cattgtattt ggttttatcg 3981781 tgaatatcac agaacgggtc tttacctcga acttatacgc ctatacatct gaaccttatc 3981841 cgactgaata ccgctcgtct ggcagcggtt tagcctatgg tcttggccgt ttttcaaaca 3981901 tttttggctc attgcttgtc ggatttattg ccgttcagct cggctatatc agcgtcttct 3981961 tatttattgg gggctgttgg ctcgcatgct ccttgctgtt aatcttcttc ggtcctaata 3982021 cgaatgcaaa acagatttaa aaaagtcagt gcggatctgc cgcactgatc tcattacaat 3982081 tgcttcaaaa tccttgcggg gtttccgcct acaacagtat tagcgggtac atccttagtg 3982141 acaacagatc cagaagcaat cactgcgtta tcaccgattg tcactcccgg gttaatcacc 3982201 gcccggcctc caatccaaac ttgatctcca attgtcacag gcttaccgaa ctccttcccg 3982261 gatttccttt cgatcggatc aagaggatga ccggccgtgt agatatgtac acctggcgca 3982321 atcaaacaat gacagccgat acgcacctca cacacatcta aaatgacaca gtcaaaatta 3982381 acaaatgtat gatctccgat atgaatgtga tagccataat cacagcggaa tgtcggcaaa 3982441 atcgtgactt gatccccaac cgaaccgagc agctccttca aaagcttcgt ccgcactgca 3982501 tcatcttccg gtgtttcgtt gtattgtcta atcagctgtc tcgcatgctt gcgttctagt 3982561 aatagttgtt gatcttccga attgtataat tctccggctg ccattttttc tttttctgtc 3982621 ctcagcattt aagtcactcc agatgtcaga ttgtaatctc gatcaaattt ccttcatcat 3982681 cctcaatcac gctttcatag tagccgtctc ctgttgtcct cgggccgttt actactgcga 3982741 aaccatccgc cttcaatcga tcagtcagtt cgtcaacttt ctcccggctc ccaacggaaa 3982801 aggcaatatg tgcccagcct gtcattgttt gtgagggcgg atcggtcaca ttcccttttt 3982861 tcataatttc cagccttgct ccggaatcaa acgtaataaa ataagactta aaatcttttt 3982921 tctcattatg atacaaatca ttcgcttcgc cattaaaata cgattcataa aaagacttca 3982981 ttcgctctaa atcattgacc cagaccgctg tatgttcaat ctgcatttct tcctcctcct 3983041 tcgccttcaa tgaagttata aggtatgaaa tgcatttcag ttcaagcttt tttcttaaat 3983101 ttatgctgaa ttttgatatc agcgggttca tcctgcaaaa atagagaaaa tgctgcgatg 3983161 ccgagctgct caagattcaa atcaagcgac ggaaaaccaa gaacacggct gatagaagta 3983221 tttccctcgc ctatgatttc aacatcccaa ttattctttt tggcaaatag atgaattcca 3983281 gctgccactt catcactatt tgcataaata gcagtcggaa cccgcccgct catataaaaa 3983341 tgttcagctg ccagctcacc atcattcata tcgttgcatc cggacagcat atggcggtct 3983401 tccaaccttc cgcagacagc tttataggcc gcagctttat cagccgtgct cgggctccta 3983461 tcagcttctc tgacacacgt aaaagcaata ttctcatgcc cgcggctctt taaatagcga 3983521 aagctctctg cataagcagt ttttctgtca ttaaaagcac aagggacatc aatgtctccg 3983581 gtatcctcac aagcgatgac cggcccatat tcctgataag ctaaaatgct gtcccaatga 3983641 ttggcgcggg aagtaatgat gagaccgtct attttcttcg ttcttaacag ctctaaatat 3983701 ttgatttcaa tatcggggtt ataattggtg gggagaaggg tcgttgcata ctcatgctga 3983761 aaagccgcct tggtgattcc gttaacgatt ttatcaaagc agggatgatc gctataaggc 3983821 agaatcacac cgaccgtatg ggttttcccg cgaatgagat cgattgcggt tcgatttggt 3983881 gtataatcca attccttcat gacttgatga acaagctttc tcttttcttc agatacatac 3983941 ggatgatgat tcaatacacg cgagacagtc gaaacagata catttgccag tcttgcgatc 3984001 tcttttatat ttgccatctc tttctccttt tcatataaaa aaagcagtaa gtgtaaaatc 3984061 cttactgcta tctcatcata tattgatgat aagttcaaca ggacaatggt cggaacccat 3984121 gacgtccgct gatatgctgg catcttcaat ctgttcctta aggctttcag aaacaacaaa 3984181 ataatcaatc cgccatccaa tatttctgtc ccgggcgccg gcacgatacg accaccagga 3984241 ataagcgcct tcaagatcag gataaacatg acgaaaagaa tcaacaaagc cagcttctaa 3984301 gaaacgagtg aatgcctctc tttcttgatc tgaaaatcca gcgttattcc ggttcgcctt 3984361 tggatttttc aagtcaatct cctgatgggc tacattcaaa tcaccgcata aaatcactgg 3984421 ttttttctga tccaattcaa gaatataaga cagtaaagcc tcttcccatt gcatgcggta 3984481 atcaatccgc tctaatcccc ttctggaatt gggcgtgtaa acagtcatca caaacacgtt 3984541 ttcaaattcc agcgtaatca ctctgccttc ttggtcatgc tcttctactc cgataccgta 3984601 gatgacctgc agcggttctt gcttagaaaa aacagctgtg ccggaatatc cttttttcac 3984661 tgcataattc cagtacacat gatagtcttc aggctggaga tcaacctggc cgtcctgtat 3984721 cttcgtttcc tgaagacata taatatctgc atcctcttct ttcaaataag agaggaaatc 3984781 catttttctc atcacagccc gcaggccgtt tacattccat gaaatcaact tcatgtttca 3984841 tcctcccccc tataaaaaag agcaagaacc cgaaggtcct tgctctttac atatcagctt 3984901 actcaccgct tacgtatgga agtaaagcca tttgacgtgc gcgtttgatc gctgcagtca 3984961 atttacgttg gtatttagcg tttgttccag ttacacgacg tggtaaaatt ttaccgcgct 3985021 cagaaacaaa ctttttaaga agatctacat ctttgtagtc gatgtgcgtg ataccgttag 3985081 aagtgaaata acacacttta cggcgtttcg cacgaccgcc tctgcgtcct cctgccattg 3985141 tcatttccct cctttctttt tcattttagg cgataatcac attagaatgg aagatcatca 3985201 tccgagatgt caatcggttt gccgtcgttg gcaaatgggt catcattaaa gctgttcccc 3985261 tgattgcgtc tctggttgtt ttgatttccc ccaaatggat tatcattttg gcctccgcca 3985321 aagtactggc ctccgccgct gtttccttcg ttgtatccac ctgaaccaga accgccgccg 3985381 tttttcggct caagaaattg aacactttca gcttggacct ctgtcacgaa gacacgctgt 3985441 ccttgctggt tttcatagtt tcttgtttgt aaacggccat ctacgcctgc aaggcttcct 3985501 tttttcaaga agtttgcaac gttttcggct tgtcttctcc aagtgacaca attaatgaaa 3985561 tcggcctcac gttctccgga ctggttcgta aatgtacgat tcacagcaag agtaaacgta 3985621 gcaacagccg caccgtttgg cgtataacga agctctgggt cttttgtcag tcttccgact 3985681 aatacaactc ggttaagcat aagaaagacc accttttacc attatatatt tcaaaattgc 3985741 ttattcttct tctttaacaa caatgtggcg aatgatatcg tcactgatct tagctagacg 3985801 gtcaaattct tgaactgccg cagcgtcaga ttgaacgttt acgatttggt agaaaccgtc 3985861 gcggaaatcg ttgatttcgt aagcaagacg acgtttaccc caatcctttg ttccagtgat 3985921 ctccgcaccg ttagaagtca gaacgttgtt gaaacgctcg ataactgctt ttttagactc 3985981 ttcgtcaatg tttgggcgga taatgtacat aacttcgtac tttctcatct gtttgcacct 3986041 ccttttggac taagcggccc ataatgggca aggagcaata attctattac tcacaatttt 3986101 atattatacc aaagctcttg tccctttaca actgcatcct atacattaaa tcggaaatga 3986161 ataacatctc cgtcttggac cacatattct ttcccttcaa ggcggacttt tcctgcctct 3986221 ttagctcctg ccataccgcc gcccgcaaga agatcctcat aagcaactgt ctcagcacga 3986281 atgaagcccc gctcaaagtc actatgaata attcctgcac actcaggggc tttcatgcct 3986341 tttttgaatg tccaagctct gacttcctgt tctccggctg tgaaatatgt tgcgaggccg 3986401 agaagagagt aagacgcttt gatcagctga tcaagacctg attcttgaat gcccagctct 3986461 tccaagaaca tttgcttttc ttcgccttca agctcagcga tttcagattc gatttttgca 3986521 cacacaacga taacttctgc gttttcgccg gcagcgtact cgcgaatctt cgctacattt 3986581 tcattgccag atggatcagc aacttcatct tcacttacgt tggccacgta caaaataggc 3986641 ttcgaagtca gtaaatggag ctgcttcaca agcttttgct gctcttcagt gaattctaca 3986701 gatcgagcag gcttttcact ctcaaacgct tctttcagtt tagataaaat ctcaaactca 3986761 aatacagcgt ctttatcttt ttgcttcgca agcttgctga cgcgtgtaat ccgcttttca 3986821 actgtttcca tatcagcgag gatcagctca aggttgatcg tttcaatgtc atcaatcgga 3986881 tcaacctttc cggaaacgtg tgtaatgttg tcatcggaaa aagcacggac aacgtggcaa 3986941 atcgcgtcaa cttggcgaat atgagatagg aacttgttgc cgagtccttc tcctttagat 3987001 gcgcccttta caatccctgc aatatcagtg aattcaaaag cagtcggcac agtcttcttc 3987061 gggttgacca gctcagtcag cttttgcaga cgatcatccg gcacctctac aattcccacg 3987121 ttcggatcaa ttgtacagaa cgggtagttg gctgattcgg caccggcctg tgtaattgcg 3987181 ttaaatagtg ttgattttcc gacgttcggc aaaccaacaa ttccagctgt taaagccatt 3987241 ctttcatctc ctctatataa aaccgtcatt gtatgaacgt attttgaacc tagagcaatt 3987301 ataaggaggt tcactggaaa agacaagctg acaaaaaagc attttcagct tgccaatccc 3987361 tttgattatg cttttttcaa gcctactaaa cagtcaaaaa gcgtacttcc cattccatta 3987421 tcagaatttg tatcatttgt cagtgcattg actgaccctc caaaagccgc ccacatgcct 3987481 tcatctatat taatcgtctt cgcatgagcc tgcttcatca ctttcacctt gcccttcatg 3987541 cttccgcggt cattaaagat gacaacttcg tctccatcct gaagatcctg cccagccgct 3987601 atatctggag aaatatcgac ctgaacgtgc tgaagctttt caataaacgg cacatgctgt 3987661 gaatgattgg aacgctgcgg atgaatggat aagagcgtat aagggtactt tccagctaac 3987721 tcctcattat ggaaaacaga ttcttcgggc acatttaatt gaagcgagcc gctaaatcct 3987781 ttttgctcag ctagcgacga agtaaattca aattttccac tcggcgtcaa aaactgataa 3987841 tcatcccacg gcacctgttt tactggaaga gggaggtggc ctttttcttt taaacgctca 3987901 agtgtcacat cctctgcttc caatgaagaa agccccatct ctaaaaattc ttgagtgctg 3987961 tattcaaaca gctcgccaaa cccaagacgt tttgcaagct ctgaccagat ccagctgtcc 3988021 gatttcgctt caccctgcgg ctccacaagc ttcttcccgt actgaacata atgatgatac 3988081 atactggaat agtagatatc ttcttcttca aaaacagtgg cagtcggcaa aacataatca 3988141 cacagctctg cggtatccgt cataatggaa tcaatcgcga ccgtcattgg aaccttttca 3988201 aatgcttgtc tcaccttatt tgtattcggc acctgagtca gcggatttcc gcacgtcaca 3988261 ataatcatct caatcgcagg atcagcagcg gtcaacactt cttcagcctg tgtcatcatt 3988321 gaaaaagaac gggatgttgt ttttaattcc ggcagcgtca gctttgtttt tgcaaagctc 3988381 tcaccaatct ggacatttcc gaaattcgcg ccgccgccct taattccgac atttccgctt 3988441 gccgccacaa gtgcatcaat ccaacgaatc gttcccccgc cgtttttata tcgctgcatg 3988501 ccaagcccca taaaagtaga caccggacca tcagcataca aacctgccaa atactccagc 3988561 tcctccatag aagtttctgt tttcacaata aactcttcca gagaaacggt cttcaaaagc 3988621 tctttcacat catcaaaacc gacagaatgc tcagaaataa acgtttcatc cgttcttccc 3988681 atctcaatca gaaccttcaa aacggctgcc gcaagccagc cgtccattcc aggctttaca 3988741 gagatatagc ggtcggcaag cttagcagtc gggttgaaga tcggatcaat caccgtaatc 3988801 gtggcgccct tctttttcac ctgctgcaag tgatggtata agtgcatatt tgttcttgat 3988861 acatttcttc cccacacaac aacatgcttg ctgttgtaaa tatcaagcgg tccgtgaccg 3988921 tacgaacggc caaaatccca gctttgcgcc tcgataccgg agccccagca tatgcttccg 3988981 acgatttcgg tcacgccgcc atatccatta aaaaaacgct gatcaagcgc ttttaacaga 3989041 ccgttattcg cataatcatg gctgtgcaaa acagcagtcg tctccgacgt ttccttgatt 3989101 tcccgaagtt tatcggcaat ttcatcaagt gcctgctccc aagaaatccg cacaaactcg 3989161 ccattttgtt ttttcattgg atagcgaagc cgatcaggcg aatttgtttt tgtctcaagc 3989221 attctgccgc ggccgcagat tttaccttcc gtaatcggat ggtttggatc tccgtccact 3989281 tttgttacct ttccatcatc aacagtcacc aaaaagccgc agctgtccca acaattcagc 3989341 ggacatgccg actgatgcac tttgctcatc gccgtcttct ccttaccttc tatatgaaaa 3989401 agcatgagtg tcggcctatt tatgaagtag gctcctcatg cttgactagt acttttttta 3989461 gttttctttc aaattctctt ctcggaatca taacactgtg agagcatccc tcacacttaa 3989521 ttcgaatatc cattcccatg cgtataattt tccagctgtt cgctccgcat ggatgcggtt 3989581 ttttcatttc tacgatatca ttcaggccaa agtctttatc cgccaagacc cttcacctct 3989641 tttcctaaac tgctgtatct attgtacaaa aaaactgatc ataagagcaa tcaagatacc 3989701 cgaaaagaaa tacatcctct tatttccatt tactcaaaat aggatataag agcagacaaa 3989761 ctaacaaata caaattgagc atcccatata tcggatacaa gaacgcgatc aaatcagaaa 3989821 atccgaaaga agtaaaaggt accattaaca ctaacaaaat caacacaatc atccatctcg 3989881 gcatatgaat aaacgccatc agccggctgg acaaacccag caaaccagct accgtcgtcg 3989941 tgtaaatcgc caggcacagc accgccgtca tacataaaaa aaggaaataa ggcgcaccct 3990001 ccagaacggc aaacagcggt atttcaaact gagaaaggga gcccgccagc tccaccaacg 3990061 tttcattata aacaaatgag atcacgccaa aaataagacc gcttgccaca cttgcgattt 3990121 ttgcttctcc gagccctttc atctctttcc caacagagga taaaatcgca acaactgaaa 3990181 ggatgtttaa agaggtaaac gtaatgctcg caggccagtt atactgctgg gacaaatcaa 3990241 tcgtccacgt atggtgatgt gtgctctgaa aggagatcag cgcatataaa agccccgcta 3990301 ctaacacagg aatcaaaata ctatttatag ataatattcc tttcacatcc cacaaaaaca 3990361 agcacactgt cacgatgcaa atcagcgtga ttccccacca gaaaggaagc ttgtacattt 3990421 gcagggtcac accgcctccg gcaatcatca ccatagtcgt cgaaaacaaa taaaaaatga 3990481 tgaggacatc ataaattttc gccagccatg gccccattaa atgctccaga accggcagaa 3990541 aatgagtgga ttgaacctta aaactgattt tcatcacaat ataagacgag aaaatgaaca 3990601 taattgtaaa cagcacaata gcaagtccgc tttccgcccc aaaaaactgc catatctcct 3990661 gaccgctcgc atatccggcc ccgatcaggc tccctaatat gagcagcatc cacttcattc 3990721 cggctctcca caacactatc acctcataga caaagttcag cttgttcccg ttattgttac 3990781 tatataaata aaggaaagca aacatgccat attttcatag acatttgaac acaagctgaa 3990841 attatcatac gaaatacaca taaaaaagac tgctaatacg gcagtctaaa aagagatatt 3990901 tatttgtttg tccgcggaat gaagaagtga acttcactct tcactttttt ctaaccattc 3990961 ctacctattc aagtgtttca taagcagacc attgcttgat catgatcgag gcaatggggg 3991021 acaatacttg taatcgccca ctaaccattc atatcatgcc ctctactttt ttaaaatctc 3991081 tggtgccata cacaaagcat aaaaaatcat actgctggat atactgtaaa caaccttaca 3991141 taactacaca caccatagca attctgttac ctactataac aaggaagtga aacccatgaa 3991201 tcgaaaaggc gggctttttt cttctcagga acgagtaaag caatatgttt cacatacaga 3991261 tgctgcagcg gcaaaacaaa tccaaaccat cctttcttca tccttacgta aagctgctgg 3991321 caaaccaatt gtcgtggttt gtatcggaac agaccgttca accggtgact cattaggccc 3991381 gctcgtagga atgaaactca aacagatgca gctcaccaga ttccatgtct acggaacctt 3991441 atctgacccc gtccatgctg tgaacatgaa ggataaaatc aatgacattc ataaattaca 3991501 taaaaaccca tttgttatag cagtcgatgc atgcttaggc cgcgttaaga gtgtgggttc 3991561 atttcaaatc ggggacgggc cattaaagcc cggagccggt gtacaaaaag accttcctga 3991621 agtgggagat cttcatatta acggaatcgt gaatgtgagc ggttttatgg aatattttgt 3991681 attgcaaaat actagactca acttggtcat gaatatggca aatgttctag cggaaggttt 3991741 gagtttaaca gatcggacag agtggaggca agaacgcctt aacccgttgc aaaggctcac 3991801 tgggcgcata taaaataaaa accatcttcg tttgaaagat ggttttttca tttatgattc 3991861 tcgttcagac aaaagctcta aaatccggtc aaggtcttca ttagagaaaa attcaatttc 3991921 gattttgcct tttttcttct gtcttttaat attaactgtt gttccaaaat aattttggag 3991981 ataggattcc cgttctttta gaaccgcatc tttcacaggt tcttttttct ttgtttcacg 3992041 tggaacattc tgattcaact gctgaatcag ctgctcaagt tggcgaacat tgagctgctc 3992101 cgcaatcact ttttgtacca gcggttcaag cttatttttg ttttttaagc caagaagcgt 3992161 gcgtccatgt cccatagaaa gcgtgccttc ggcaataagc tgttgaatat tttctggcag 3992221 tgtcagcagt cttaaatgat tcgcaatatg cggtctgctt ttcccaagac gtttggcaag 3992281 ctgctcttgt gtgagatcta agtgtttcaa aagggagtca tatgcctgag cctcttcaag 3992341 cggagataaa tcttcacgct gaaggttttc taataaagca atttccctca ttaacgcctc 3992401 tgataattca cggacaatgg ccggaactgt atctaaacct gccagctttg ccgctcgaaa 3992461 acgccgttca cccgcaacaa tatcatagcc ttttaaagat tttctgacga taagcggctg 3992521 aagaatgcca tgctgcagca cagattcttt tagttcagct aatgcctcgt catcaaagtg 3992581 ttttcttggc tgataaggat tagggcgtaa atcggcaatt ttaatttctt caactgtctc 3992641 ttcagacaaa tctacctgat taaataacgc attaatccct tttccaaggc ctttagccat 3992701 tcgcagccac ttcctttgct aaatctaaat atacttccgc acctcttgac cgcggatcgt 3992761 ataaaatgat gggttttccg tgactcggtg cctcactcag acggacatta cgcggaataa 3992821 ctgtcttata tactttatcc ctaaaatact ttttaacctc ttcaatcact tgaatgccaa 3992881 ggtttgtccg ggcatcaagc attgtcagca atacaccttc aatcattaaa tcagtattca 3992941 aatgcttttg cacaagacgt actgtattta ataactggct gagaccctcc aaggcataat 3993001 attcgcactg tacaggaatc acaacggaat ccgaggcagt aagggcatta atcgtcagca 3993061 agcccaatga cggcggacaa tcaatgataa tataatcata attttgcttt actgcttcaa 3993121 gcgctctctt caatctcact tctcttgata ttgtaggaac cagctcgatc tcagcccctg 3993181 caagctgaat cgtcgcagga atcacatcca agttctctac tgtcgttgct ttaataatat 3993241 ctattacatc tgcatcatct actaaaatat cgtacacaca ctgctctaca tcggcttttt 3993301 caatccctaa tccgcttgtc gcatttccct gcggatcaat atctaccagc agaacccttt 3993361 tccctatgta agccaaacat gccccaaggt tgacagacgt cgttgttttg ccgaccccgc 3993421 ctttttggtt cgtaattgct atgatttttc ccacgatgtc acctactttc acatgaacat 3993481 gtactatctt gcttctattc tatcaaaaaa agattaaagc gtttcatttt tttcatcatt 3993541 ttgttccgaa tcagaaggga aataattgaa aattcaagca cgctttatgc tttctcttat 3993601 aaattctgca atttctatgt ttttttgact taaaaaagga atttcttaaa gaaaaaaaga 3993661 agaagtcaca gtacagaacg tggaaacagg atggtgagaa aatggtttat caaacgaaga 3993721 gagatgtacc cgttacgctg atgattgtgt ttctcatatt actgatacaa gcagatgcca 3993781 ttgttccttt tgtgctggga aatatgagag tttccggctg gatcattttt attctgctga 3993841 ctcttttaaa tggactcatc atttggagct ttattgacct aaaatatgta ttgaaggaac 3993901 accatctgat cattaaagcc ggattgatca aacatcaaat tccttatgaa aacatcgata 3993961 aagtcgttca aaaaaagaaa ctatggtccg gttttcgtct gatcggctct cgccatgcca 3994021 tcacaatata ttatcagggg ggatggggac atgcagtaat ttcaccgcaa aaatctgaag 3994081 aatttatcca caagctcaaa gaaaagaatt ctaatataat aatattcact aaaagtaagt 3994141 gattaccttt tgttaaaaat ataaaaagct ctcctgcttt tcaggagagc ttctattttg 3994201 gtatgcgaat cgttaattga atatattctt caaattcttc ttcttccgta ttcaatttta 3994261 caccgctgtc ttccaccatt gatagtgact ggcgaatcgt gttcatcgca attcttgtat 3994321 ctctgctgaa tgctttgcgt ctcggctttg gctttctctg gccttgctcc agcattttca 3994381 ccacgcggtc ttctgtctgc tttacattta aacttttctc aataatctct gtgagcagtg 3994441 tgacttggag ctcaggctgt ttcagcggaa tcagtgctct ggcatggcgc tcggtgattt 3994501 tcttctccat aatcgcctct tggaccggct gaggcagctt taataaccga agcttattcg 3994561 cgattgtaga ctgccctttt cctaagcgct gtgcgagtgc ctcctgtgtt aaatcatgca 3994621 gctcaagcag cctagcataa gcatgcgctt cctcaataga agacagttct tcccgctgca 3994681 agttttcgat taacgccaca gaagcggttt ccgtgtcgga aaaatcctta ataattgccg 3994741 gaatcttttc ccactcaagc gattgcaccg ctctccagcg tctttcacct gcaatgagtt 3994801 cgtattggcc ttcttcttct gtatgcctaa caacaatcgg ctgaataatg ccgtgtgtat 3994861 gaatggtcat tgctaactct ttgatttttt catctgagaa aatggtgcgt ggctgaaaac 3994921 ggttgggaac gatagcattt accggtattt ccagaatctc ttctttgttt gtatcatgtt 3994981 cagcaatctc cggctcctgt tccttctcac caagcccgaa gaaacgagag aatgaatgct 3995041 tcatgtacct acaccacctt taaaaactgc catttttata attctatttt ctcatggttt 3995101 ttcctgctgt acatccatca attttgatga aaatatgatg gtattgtcat atcaggctgt 3995161 ctaaattacc cttcaattgg cgatttatta ggagttcccg gttttcttgg atacttctta 3995221 ggtgtatttt ttattttgcg tatcaccata atattacgat cgctttcttc aataggcagc 3995281 ttaaaagaat ggatattctc aagttctcct ccaagcgtcg tgattgcttt tttgcctgca 3995341 ttcagttctt cttcagctga tgcggctttt aaagcaacaa ataaaccgtt tttcttcacc 3995401 agaggcaagc aaagctcact caaaacagat aatctcgcaa ctgcgcgcgc cgtcacaata 3995461 tcatagcttt cacgcacgtc tttccgttgc ccgaacgttt cagctctgtc atggcagaat 3995521 gttgtattct ccaattgcaa agcttcagac aacttttcta aaaacgtaat ccgtttgttt 3995581 agtgaatcca cgattgtgac atggaggtgc ggaaagcata tttttatcgg cagacttgga 3995641 aaacccgctc ccgctccaac atcacaaatc gtgttcacct gattgaagtc gacataaaaa 3995701 gcagctgtaa tggaatcata aaaatgcttt aaatacactt cttttttctc tgttattgaa 3995761 gtcagattga ttttttcgtt ccattcaacc agcatgtcgt aatacagctc aaattgctcc 3995821 agctgacggg gagaaaggga gatccctttt tccgccaaac cagaagtgaa ttcttcaata 3995881 ttcatgccgt catcctttct actcggctat cttcgcaatg cgtccctgct ctaaatacac 3995941 caatagaatt gaaatgtccg ccgggtttac accggaaatg cgggaagcct gggcaacaga 3996001 caaaggccgt acatttttca gtttttgacg cgcctcggtc gcaatcccct taattgcgtc 3996061 ataatcaatt cggtctggaa tttttttatt ttccatcttc ttcagttttt ccacttgctg 3996121 aagagatttt tcaatatatc cttcatattt cacttggatt tctacttgtt ctgccacgtc 3996181 ttgaggaacc ggcacttctg gcggcgccag ttttgtgact gtttcatagt tcatttcagg 3996241 acgtttcatc aagtctgtgc cgcgaactcc atctttcaat tcgcttccgc caagagaacg 3996301 gatatattct tgattttccg gagacggctt gataattaca gaatgaagac gttttttctc 3996361 cgcctcgatc gccgcttttt tcttctcaaa agccgcatag cgctcatcag aaatcaatcc 3996421 aatgcgatgt ccgatttctg tcagacgcaa atcagcattg tcatggcgaa gcagcaatct 3996481 gtattccgca cgtgatgtca aaagacgata tggctcattg gtaccttttg tcacaaggtc 3996541 atcaatcaga acaccaatat aggcgtcaga acggcttaga attacttctt cttttccaag 3996601 cgcttttcgt cctgcattga ttcccgccat aatcccttgt cccgcagctt cttcataacc 3996661 ggatgttccg ttaatttggc ctgcagtata aaggtttgtg atttttttgg tttcaagtgt 3996721 cggccatagc tgtgtcggta cgattgcatc atactcgatc gcatagccgg ctctcatcat 3996781 ttgcacgttt tcaagtccag gaatcgttgc aagcattctt tgctgtacgt cttctggaag 3996841 acttgtagat aaaccttgga catagacttc ctgtgtattt ctgccttccg gctcaaggaa 3996901 gatttggtga cgcggtttat cattaaaacg gacaactttg tcttcaatgg atgggcagta 3996961 tcttgggccc gtacctttga tcataccgga atacatcggt gaacggtgca ggttgctgtc 3997021 aataatctca tgtgtctcag ggcttgtata tgtcagccag caagggagct gatctgtgat 3997081 atattccact gtttcatatg agaaagcgcg aggcacatcg tcaccaggct gaatttccgt 3997141 tttgctgtaa tcaatcgtgt cgcttttaac gcgaggcggc gtacctgttt taaaacgaac 3997201 aaggtcaaaa ccgagttcct ccaaatgctc agaaagctta atagaaggct gctggttatt 3997261 cgggccgctt gagtaagaca gatcgccaag aatgatacgt cctcttaaat atgtccctgt 3997321 cgtcatgaca actgctttcg cacgataatg tgcgcctgtt tgtgtaataa cgcctcggca 3997381 ttcgccgtct tcaacgatca gccgctccac aattccttgc agcaatgtta agtttggttc 3997441 tttttcaagc gtatttttca tttcgtgctg atattggaat ttgtctgctt gcgcacgcaa 3997501 tgcacgaacc gcaggacctt ttcctgtatt cagcattctc atttgaatat gtgttttatc 3997561 gatgtttctt cccatttctc cgccgagcgc gtcaatttcg cggacgacaa tcccttttgc 3997621 ggggccgccg acagacggat tacatggcat aaatgcaacc atatctaggt tgatggtcaa 3997681 gacaagcgtt ttggcgcctt ggcgtgcaga tgcgagggca gcctcaacac cggcatgccc 3997741 ggcgccaatc acaatcacat cgtattggcc tgcttcatac cccatgattc tagttcctcc 3997801 tttaattatt ttcctaaaca gaattgagaa aagagctgat caattaagct ttcgtggaca 3997861 gaatctccaa tgatttcccc taaaagctcc cagcatcttg taaggtcaat ttgcaccatg 3997921 tcgatcggga catcctgttc gatgccgcta agcgcatctt caatggcgcg ttttgcttgc 3997981 tgtaaaatag tgatgtgacg tgtgttgctg acataagtca gatcaccgct ttcaatggca 3998041 cccgtgtaga acagtgattg aatcgcttct tccagatcat tgatgccttc ctcttttaaa 3998101 agagatgtcg taacaactgg acgtccattg gcaagctcac ggacacgttc agtgtcaatc 3998161 ttcggctcaa ggtcagtctt attcaaaatc acgataacat ccatgccctc aacggcttca 3998221 aaaagcttca cgtcttcttc agaaagctct tcactataat taagcacaag taaaatcagg 3998281 tccgcttcct ttaggacctg gcgagaacgt tcaacaccga ttcgctcaac aatatcctct 3998341 gtttcacgaa tacctgctgt atcaaccaga cgaagcggaa cgccccttac attcacgtat 3998401 tcctcaatca catcccgtgt cgttccggga atatcggtta caatggcttt tgcctcatga 3998461 acgaggctgt tcagaagaga tgattttcct acgtttggcc ggccgataat gacggtagaa 3998521 agaccttcac gcaagatttt tccttgctca gaagtcctca gcagcgtctc aatttccttt 3998581 ttcacggcgg ttgccttttc gactaaaatc tgatgcgtca tttcctctac atcatcatac 3998641 tccggataat caatattcac ctcaacatgg gccagtgttt ctaaaatctc actgcgcaaa 3998701 cggcgcacca aagcagaaag acgcccttcc atttgattca tagcaacgtt cattgcccgg 3998761 tccgttttcg ctctgattaa gtccataacc gcttccgcct gtgaaagatc gattcggccg 3998821 tttaaaaacg cacgtttcgt aaattcacca ggctctgcca gtctcgctcc ctctctcaat 3998881 gcaagctgaa gcacttggtt cacagtcaca attcccccgt gacagttaat ctcgatgaca 3998941 tcttctcgtg taaaagttct cggcgctttt aacactgata ccattacttc ctcaacgaca 3999001 cgatccgaag gtctgtctac gatatgacca taatgaatcg tatgtgattc gaccgagctg 3999061 agtgttttcc ccttcggtcc cttataaatt ttatctgcga tttgaatggc ttctggtccg 3999121 ctcaaccgta caatcgcaat cgcgccttct cccatcggtg tggaaattgc cgcaattgta 3999181 tccatgttgt tcacctctct ttacttatac ttcatctata taaaaaaatt tttattatgc 3999241 caaaactaaa agataacata gtttggttcg aagtggaaga tttgttatcc acagaaatag 3999301 aaattcgtcc cttattactt taacttatcc acatgtgaat aacaattaat tttatttcct 3999361 gaacttcctt tttatcaaca ggatacacct aaaaagaaaa aacttaaacg gcaaaacctt 3999421 gatattacta ggaaaagtag atttttcgga tacaaaaaaa ccgaaatcca atttttatcg 3999481 gacttcggtt ttatgctatc ttttatggga aataacgaga tgacgatttt cgccttcacc 3999541 cattgaatat gttttgatct ggtggtttgc atatccagaa agagtatcgt gaataatttt 3999601 tctttcgctg gacggcatgg gctcaagctg gatggatttt ttcgttttca aaacctggtc 3999661 agcaagcttg atggccagct ggctcagtgt ttcttttctt ttcaaacgat agttttctgc 3999721 atccaccgtc acatttttat attggcctgg ataacggtta agggcaagct gtgtcaaagt 3999781 ttcaagggcg tttaaagttt gtcctctttt cccaatcaac aatgctgcct tttcacctgt 3999841 tatatgatat ctcactgtct ttttgctttc ttgaacagtc acatcagact tcccggcaat 3999901 ggcttcggca atcgtttgaa gatataactt cgcttgctga atcggatcaa tcttttcaac 3999961 cagctttacg atcgcaggct ttttaccgaa aataccgaga aaccctttgt ttccctcttc 4000021 aataacagta atttctacct tatccttcgt taatcccaac tcttgcaatc cggactgtac 4000081 tgcttcatcg acatttcgcc ctgcagcagt cacattcctc actttttctt tcctccggct 4000141 ttttgcggct caggattttt tttaatatca ggtcctttaa tgaggaaagt ttgcgcaatc 4000201 ataaacaagt taccaactac ccaataaaga gaaagagccg ccgggaagtt gatcgcaaat 4000261 acgataatca taattggcat aatccaaagc atcatcgcca tttgcggatt ttgctgcgca 4000321 ttgccagcca tcatcagttt ttgctgaaca aatgtagcga caccggcaac gataggaaga 4000381 atatagtaag gatctttttc tcctaagtca aaccataaga agctatgctc tgaaatcgcc 4000441 tgggttctca tgatcgcatg atagaatcca attaaaatcg gcatctggat caaaatcggg 4000501 aaacatcccg ccaatggatt gacaccatgc ttttggaata aagccattgt ttcctgttga 4000561 agcttttgct gcgttttttg atcctttgag ctgtattttt ctttaagctt ttgcatttcc 4000621 ggctgtaaag cctgcatcgc tttcgaactt ctcagctgct taatcatcag cggtaaaatt 4000681 aataaacgaa ttaaaatggt aactagaata attgaaagcc cgtagttatc tcccgtcaat 4000741 ttcgctacat acgtaatgag ctcagacaat ggatatacta cgtacttgtc ccagaaatgc 4000801 ggactatctg cagtgatcgg ctctttcaca ctcgagcatc cagccaaaag catgaatacg 4000861 ccaaccatac ttaatagcaa ccctattctc cttttcaaca acatttcctc ctataattaa 4000921 tctttacact cttttattgc aaagcatact tgtatgtatt ttagcatctt tcagttttaa 4000981 atggtgtctt tttctgatca accagaaagg aagcgctttt aaaagttgta agaaagcagt 4001041 ggtgatgcct actttgacga agatttctta tataatgaag actttctgaa tagatgctgc 4001101 agactttttt tcgtttcctc atatgtcagc tggctcgccg gttttctggc aataatgatg 4001161 taatcctttt ccttcagtct ctctttctct tcaagaaagg cctgccgaat caaacgtttg 4001221 atccgatttc gcatcacagc attgccaatt tttttgctga cggaaagccc gacacgcagt 4001281 tcatcatttt caggctgatc aagcgtatat aagacaaact ggcggtttgc aactgatgtc 4001341 ccatgtttaa acactttttg aaaatcttca tttttcttta aacgatttcg cttcttcaaa 4001401 tgactcactc cgatactggc tggcagaaac ttttaaaatt tattatgaac atgagatgca 4001461 tctgaaccag gaagcatgcc ccggttcatt acgcatcaca tctatctttt cccataacgt 4001521 gaaaaaagac cactgacatt attcagtggc ctaagctgat aatacttttc tgcctttgcg 4001581 gcgacggcgt gctaaaacta gacgaccgtt ttttgaactc atacggcttc tgaagccatg 4001641 aactttgctg cgtttacggt tattcggttg gaatgttctt ttcatttatg acacctccct 4001701 cgaggaatag ctgttaaaga cagtcttact tattatattt gcgttaccta ttcattgtca 4001761 acttcactag tgcttttatt tcttgcaacc ataataggat accatacctt ttcaactttc 4001821 gaaaccttat tttttagatt ccttaatttt acggaaaaaa gacaaattca aacaatttgc 4001881 ccctaaaatc acgcatgtgg at //